Ligand: AGS

Total number of chains: 42
Active chains: 3
Total number of genes: 17
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 16 38.1% 9MMQA
DFGin BLAminus 14 33.3% 7AKMA
None None 5 11.9% 3W8QA
DFGin ABAminus 2 4.8% 6TSZU
DFGin None 2 4.8% 5C03A
DFGout None 2 4.8% 2G2FB
DFGinter None 1 2.4% 2W5BA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AGC PKN2 PKN2_HUMAN 4CRSA 2.75 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii AGS ATPlike 646 - 984 0 SEP755,TPO816,TPO958 None Serine/threonine-protein kinase N2
CAMK CHEK1 CHK1_HUMAN 7AKMA 1.93 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 2 - 271 0 None D10R Serine/threonine-protein kinase Chk1
CMGC CDK7 CDK7_HUMAN 6XBZJ 2.8 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 10 - 312 0 SEP164 None Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8P6YJ 1.9 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 10 - 310 0 None None Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 9HIYJ 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 10 - 310 0 None D97N Cyclin-dependent kinase 7
NEK NEK2 NEK2_HUMAN 2W5BA 2.4 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiio APEdist_oooo AGS ATPlike 3 - 271 0 None T175A Serine/threonine-protein kinase Nek2
OTHER TLK2 TLK2_HUMAN 5O0YA 2.86 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 456 - 743 0 None None Serine/threonine-protein kinase tousled-like 2
OTHER ULK4 ULK4_HUMAN 6TSZU 1.9 Pseudo DFGin‑ABAminus out-na in-out nonTYR APEdihe_aaiii APEdist_iooi AGS ATPlike 2 - 285 0 None None Serine/threonine-protein kinase ULK4
STE MAP2K1 MP2K1_HUMAN 3EQDA 2.1 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo AGS ATPlike 39 - 382 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 8DGSB 4.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo AGS, LCJ ATPlike, Type1 38 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 8DGTB 3.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo AGS, LCJ ATPlike, Type3 43 - 385 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9MMPB 3.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo AGS, LCJ ATPlike, Type3 62 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9MMQB 2.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo AGS, LCJ ATPlike, Type3 62 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9MMRB 3.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo AGS, LCJ ATPlike, Type3 62 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9MMSB 3.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo AGS, LCJ ATPlike, Type3 63 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3EQCA 1.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo 3BM, AGS Type3, ATPlike 39 - 382 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3W8QA 2.2 Inactive None‑None out-out out-out nonTYR APEdihe_aaioo APEdist_oooo AGS ATPlike 39 - 382 0 None T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 6Q0TC 5.7 Inactive None‑None out-none out-out nonTYR APEdihe_aaono APEdist_oooo LCJ, AGS Type1, ATPlike 43 - 379 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 6Q0JC 4.9 Inactive None‑None out-none out-out nonTYR APEdihe_aaono APEdist_oooo LCJ, AGS Type1, ATPlike 43 - 379 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 6Q0JD 4.9 Inactive None‑None out-none out-out nonTYR APEdihe_aaono APEdist_oooo LCJ, AGS Type1, ATPlike 43 - 379 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP3K14 M3K14_HUMAN 4DN5A 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_noii AGS ATPlike 332 - 675 0 None S549D Mitogen-activated protein kinase kinase kinase 14
STE MAP3K14 M3K14_HUMAN 4DN5B 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_noii AGS ATPlike 333 - 675 0 None S549D Mitogen-activated protein kinase kinase kinase 14
STE MAP3K14 M3K14_HUMAN 8YHWA 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii AGS ATPlike 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14
STE MAP3K14 M3K14_HUMAN 8YHWB 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii AGS ATPlike 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14
STE MAP3K14 M3K14_HUMAN 8YHWC 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii AGS ATPlike 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14
STE MAP3K14 M3K14_HUMAN 8YHWD 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii AGS, PE8 ATPlike, Allosteric 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14
TKL BRAF BRAF_HUMAN 6NYBA 4.1 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo AGS ATPlike 233 - 738 0 SEP365,SEP729 None Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 8DGSA 4.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo AGS ATPlike 155 - 738 0 SEP365,SEP729 None Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 8DGTA 3.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo AGS ATPlike 151 - 738 0 SEP365,SEP729 None Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 8VYPC 3.29 Inactive None‑None in-out none-none nonTYR APEdihe_aannn APEdist_nnnn AGS ATPlike 363 - 733 0 SEP365,SEP729 V600E Serine/threonine-protein kinase B-raf
TKL IRAK3 IRAK3_HUMAN 6ZIWI 2.18 Pseudo DFGin‑BLAminus in-out in-none nonTYR APEdihe_aannn APEdist_nnnn AGS ATPlike 153 - 451 0 None None Interleukin-1 receptor-associated kinase 3
TKL LIMK1 LIMK1_HUMAN 5L6WL 2.53 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiai APEdist_iiii AGS ATPlike 330 - 633 0 None None LIM domain kinase 1
TKL MAP3K21 M3K21_HUMAN 4UYAA 2.8 Inactive DFGin‑BLBplus in-none none-none nonTYR APEdihe_aanni APEdist_nnnn AGS ATPlike 115 - 437 0 None A214G,S303A,T307A Mitogen-activated protein kinase kinase kinase 21
TKL RAF1 RAF1_HUMAN 9MMRA 3.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo AGS ATPlike 343 - 625 0 SEP621 Q156R,Y340D,Y341D,D587E RAF proto-oncogene serine/threonine-protein kinase
TKL RAF1 RAF1_HUMAN 9MMSA 3.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo AGS ATPlike 343 - 610 0 None Q156R,Y340D,Y341D,D587E RAF proto-oncogene serine/threonine-protein kinase
TKL RAF1 RAF1_HUMAN 9MMQA 2.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo AGS ATPlike 341 - 612 0 None Q156R,D587E RAF proto-oncogene serine/threonine-protein kinase
TKL RAF1 RAF1_HUMAN 9MMPA 3.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo AGS ATPlike 138 - 630 0 SEP259,SEP621 Q156R,D587E RAF proto-oncogene serine/threonine-protein kinase
TYR ABL1 ABL1_HUMAN 2G2FB 2.7 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai AGS ATPlike 234 - 502 0 None H396P Tyrosine-protein kinase ABL1
TYR EPHA2 EPHA2_HUMAN 5I9VA 1.458 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai AGS ATPlike 605 - 896 0 None None Ephrin type-A receptor 2
TYR PTK2B FAK2_HUMAN 3FZPA 2.1 Inactive DFGout‑None in-out none-in TYR APEdihe_iiiai APEdist_aaai AGS ATPlike 419 - 692 0 None None Protein-tyrosine kinase 2-beta
TYR TYK2-1 TYK2_HUMAN 5C03A 1.9 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao AGS ATPlike 579 - 869 0 None None Non-receptor tyrosine-protein kinase TYK2
TYR TYK2-1 TYK2_HUMAN 5C03B 1.9 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao AGS ATPlike 580 - 870 0 None None Non-receptor tyrosine-protein kinase TYK2

Ligand: AGS

Total number of chains: 78
Active chains: 9
Total number of genes: 25
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 26 33.3% 4Y12A
DFGin BLBplus 16 20.5% 9MMQA
DFGin BLBminus 10 12.8% 3OROA
None None 9 11.5% 3W8QA
DFGin None 8 10.3% 6Z4XB
DFGin ABAminus 6 7.7% 6TSZU
DFGout None 2 2.6% 2G2FB
DFGinter None 1 1.3% 2W5BA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC CDK7 G0SFC6_CHATD 6Z4XB 2.98 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 78 - 399 0 None None Protein kinase domain-containing protein Chaetomium thermophilum
CMGC CDK7 G0SFC6_CHATD 6Z4XE 2.98 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 77 - 399 0 None None Protein kinase domain-containing protein Chaetomium thermophilum
TYR SRC SRC_CHICK 3DQWA 2.017 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai AGS ATPlike 255 - 533 0 PTR416 T338I Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3DQWB 2.017 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai AGS ATPlike 255 - 533 0 PTR416 T338I Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3DQWC 2.017 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai AGS ATPlike 258 - 533 0 PTR416 T338I Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3DQWD 2.017 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai AGS ATPlike 257 - 533 0 PTR416 T338I Proto-oncogene tyrosine-protein kinase Src Gallus gallus
AGC PKN2 PKN2_HUMAN 4CRSA 2.75 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii AGS ATPlike 646 - 984 0 SEP755,TPO816,TPO958 None Serine/threonine-protein kinase N2 Homo sapiens
CAMK CHEK1 CHK1_HUMAN 7AKMA 1.93 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 2 - 271 0 None D10R Serine/threonine-protein kinase Chk1 Homo sapiens
CMGC CDK7 CDK7_HUMAN 6XBZJ 2.8 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 10 - 312 0 SEP164 None Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK7 CDK7_HUMAN 8P6YJ 1.9 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 10 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK7 CDK7_HUMAN 9HIYJ 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 10 - 310 0 None D97N Cyclin-dependent kinase 7 Homo sapiens
NEK NEK2 NEK2_HUMAN 2W5BA 2.4 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiio APEdist_oooo AGS ATPlike 3 - 271 0 None T175A Serine/threonine-protein kinase Nek2 Homo sapiens
OTHER TLK2 TLK2_HUMAN 5O0YA 2.86 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 456 - 743 0 None None Serine/threonine-protein kinase tousled-like 2 Homo sapiens
OTHER ULK4 ULK4_HUMAN 6TSZU 1.9 Pseudo DFGin‑ABAminus out-na in-out nonTYR APEdihe_aaiii APEdist_iooi AGS ATPlike 2 - 285 0 None None Serine/threonine-protein kinase ULK4 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3EQDA 2.1 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo AGS ATPlike 39 - 382 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 8DGSB 4.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo AGS, LCJ ATPlike, Type1 38 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 8DGTB 3.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo AGS, LCJ ATPlike, Type3 43 - 385 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9MMPB 3.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo AGS, LCJ ATPlike, Type3 62 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9MMQB 2.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo AGS, LCJ ATPlike, Type3 62 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9MMRB 3.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo AGS, LCJ ATPlike, Type3 62 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9MMSB 3.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo AGS, LCJ ATPlike, Type3 63 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3EQCA 1.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo 3BM, AGS Type3, ATPlike 39 - 382 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3W8QA 2.2 Inactive None‑None out-out out-out nonTYR APEdihe_aaioo APEdist_oooo AGS ATPlike 39 - 382 0 None T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 6Q0TC 5.7 Inactive None‑None out-none out-out nonTYR APEdihe_aaono APEdist_oooo LCJ, AGS Type1, ATPlike 43 - 379 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 6Q0JC 4.9 Inactive None‑None out-none out-out nonTYR APEdihe_aaono APEdist_oooo LCJ, AGS Type1, ATPlike 43 - 379 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 6Q0JD 4.9 Inactive None‑None out-none out-out nonTYR APEdihe_aaono APEdist_oooo LCJ, AGS Type1, ATPlike 43 - 379 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP3K14 M3K14_HUMAN 4DN5A 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_noii AGS ATPlike 332 - 675 0 None S549D Mitogen-activated protein kinase kinase kinase 14 Homo sapiens
STE MAP3K14 M3K14_HUMAN 4DN5B 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_noii AGS ATPlike 333 - 675 0 None S549D Mitogen-activated protein kinase kinase kinase 14 Homo sapiens
STE MAP3K14 M3K14_HUMAN 8YHWA 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii AGS ATPlike 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Homo sapiens
STE MAP3K14 M3K14_HUMAN 8YHWB 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii AGS ATPlike 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Homo sapiens
STE MAP3K14 M3K14_HUMAN 8YHWC 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii AGS ATPlike 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Homo sapiens
STE MAP3K14 M3K14_HUMAN 8YHWD 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_ioii AGS, PE8 ATPlike, Allosteric 334 - 675 0 None None Mitogen-activated protein kinase kinase kinase 14 Homo sapiens
TKL BRAF BRAF_HUMAN 6NYBA 4.1 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo AGS ATPlike 233 - 738 0 SEP365,SEP729 None Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 8DGSA 4.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo AGS ATPlike 155 - 738 0 SEP365,SEP729 None Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 8DGTA 3.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo AGS ATPlike 151 - 738 0 SEP365,SEP729 None Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 8VYPC 3.29 Inactive None‑None in-out none-none nonTYR APEdihe_aannn APEdist_nnnn AGS ATPlike 363 - 733 0 SEP365,SEP729 V600E Serine/threonine-protein kinase B-raf Homo sapiens
TKL IRAK3 IRAK3_HUMAN 6ZIWI 2.18 Pseudo DFGin‑BLAminus in-out in-none nonTYR APEdihe_aannn APEdist_nnnn AGS ATPlike 153 - 451 0 None None Interleukin-1 receptor-associated kinase 3 Homo sapiens
TKL LIMK1 LIMK1_HUMAN 5L6WL 2.53 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiai APEdist_iiii AGS ATPlike 330 - 633 0 None None LIM domain kinase 1 Homo sapiens
TKL MAP3K21 M3K21_HUMAN 4UYAA 2.8 Inactive DFGin‑BLBplus in-none none-none nonTYR APEdihe_aanni APEdist_nnnn AGS ATPlike 115 - 437 0 None A214G,S303A,T307A Mitogen-activated protein kinase kinase kinase 21 Homo sapiens
TKL RAF1 RAF1_HUMAN 9MMRA 3.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo AGS ATPlike 343 - 625 0 SEP621 Q156R,Y340D,Y341D,D587E RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
TKL RAF1 RAF1_HUMAN 9MMSA 3.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo AGS ATPlike 343 - 610 0 None Q156R,Y340D,Y341D,D587E RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
TKL RAF1 RAF1_HUMAN 9MMQA 2.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo AGS ATPlike 341 - 612 0 None Q156R,D587E RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
TKL RAF1 RAF1_HUMAN 9MMPA 3.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo AGS ATPlike 138 - 630 0 SEP259,SEP621 Q156R,D587E RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
TYR ABL1 ABL1_HUMAN 2G2FB 2.7 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai AGS ATPlike 234 - 502 0 None H396P Tyrosine-protein kinase ABL1 Homo sapiens
TYR EPHA2 EPHA2_HUMAN 5I9VA 1.458 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai AGS ATPlike 605 - 896 0 None None Ephrin type-A receptor 2 Homo sapiens
TYR PTK2B FAK2_HUMAN 3FZPA 2.1 Inactive DFGout‑None in-out none-in TYR APEdihe_iiiai APEdist_aaai AGS ATPlike 419 - 692 0 None None Protein-tyrosine kinase 2-beta Homo sapiens
TYR TYK2-1 TYK2_HUMAN 5C03A 1.9 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao AGS ATPlike 579 - 869 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
TYR TYK2-1 TYK2_HUMAN 5C03B 1.9 Pseudo DFGin‑None in-na out-out TYR APEdihe_oooao APEdist_aaao AGS ATPlike 580 - 870 0 None None Non-receptor tyrosine-protein kinase TYK2 Homo sapiens
CMGC MAPK14 MK14_MOUSE 5NZZE 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 4 - 353 0 TPO180,PTR182 None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5NZZF 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 5 - 353 0 TPO180,PTR182 None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5NZZG 2.6 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 5 - 353 0 TPO180,PTR182 None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5NZZH 2.6 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 5 - 352 0 TPO180,PTR182 None Mitogen-activated protein kinase 14 Mus musculus
OTHER PKNB PKNB_MYCTU 1MRUA 3.0 Inactive DFGin‑ABAminus in-in in-none nonTYR APEdihe_aanii APEdist_nnnn AGS ATPlike 3 - 286 0 None None Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNB PKNB_MYCTU 1MRUB 3.0 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn AGS ATPlike 1 - 286 0 None None Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNB PKNB_MYCTU 3ORIA 2.0 Inactive DFGin‑BLBminus in-out out-out nonTYR APEdihe_aaioi APEdist_nnno AGS ATPlike 10 - 290 0 None L33D Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNB PKNB_MYCTU 3ORIB 2.0 Inactive DFGin‑BLBminus in-out out-out nonTYR APEdihe_aaioi APEdist_nnno AGS ATPlike 10 - 290 0 None L33D Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNB PKNB_MYCTU 3ORIC 2.0 Inactive DFGin‑BLBminus in-out out-out nonTYR APEdihe_aaioi APEdist_nnno AGS ATPlike 10 - 290 0 None L33D Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNB PKNB_MYCTU 3ORID 2.0 Inactive DFGin‑BLBminus in-out out-out nonTYR APEdihe_aaioi APEdist_nnno AGS ATPlike 10 - 290 0 None L33D Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNB PKNB_MYCTU 3ORKA 1.6 Inactive DFGin‑BLBminus in-out none-out nonTYR APEdihe_aanoi APEdist_nnnn AGS ATPlike 1 - 290 0 None L33D Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNB PKNB_MYCTU 3ORLA 2.9 Inactive DFGin‑BLBminus in-out none-out nonTYR APEdihe_aanoi APEdist_nnnn AGS ATPlike 3 - 289 0 None L33D Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNB PKNB_MYCTU 3ORPA 2.1 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaioi APEdist_nnoo AGS ATPlike 1 - 290 0 None L33D Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNB PKNB_MYCTU 3ORTA 1.9 Inactive DFGin‑BLBminus out-out out-none nonTYR APEdihe_aannn APEdist_nnnn AGS ATPlike 1 - 289 0 None L33D Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNB PKNB_MYCTU 3ORMA 2.5 Inactive DFGin‑BLBminus in-out out-none nonTYR APEdihe_aanii APEdist_nnnn AGS ATPlike 10 - 289 0 None D76A Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNB PKNB_MYCTU 3OROA 1.9 Inactive DFGin‑BLBminus in-out out-out nonTYR APEdihe_aaooo APEdist_oioo AGS, NHE ATPlike, Allosteric 9 - 288 0 None L33D Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNG PKNG_MYCTU 4Y12A 1.9 Inactive DFGin‑BLAminus out-none in-out nonTYR APEdihe_aaiii APEdist_oiii AGS ATPlike 83 - 404 0 None None Serine/threonine-protein kinase PknG Mycobacterium tuberculosis
OTHER PAN3 PAN3_NEUCR 4BWKA 3.3 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa AGS ATPlike 235 - 646 0 None None PAN2-PAN3 deadenylation complex subunit pan3 Neurospora crassa
OTHER PAN3 PAN3_NEUCR 4BWKB 3.3 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa AGS ATPlike 235 - 646 0 None None PAN2-PAN3 deadenylation complex subunit pan3 Neurospora crassa
OTHER PAN3 PAN3_NEUCR 4BWXA 2.85 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa AGS ATPlike 234 - 646 0 None L510M,G511P,G512M,T514G,T515A,H516R,L517F PAN2-PAN3 deadenylation complex subunit pan3 Neurospora crassa
OTHER PAN3 PAN3_NEUCR 4BWXB 2.85 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa AGS ATPlike 234 - 646 0 None L510M,G511P,G512M,T514G,T515A,H516R,L517F PAN2-PAN3 deadenylation complex subunit pan3 Neurospora crassa
OTHER CK2024380 A0A2I0BRS6_PLAFO 9EMYB 2.814 Inactive None‑None none-na in-in nonTYR APEdihe_aaiai APEdist_iiii AGS ATPlike 158 - 560 0 None None non-specific serine/threonine protein kinase Plasmodium falciparum
OTHER CK2024380 A0A2I0BRS6_PLAFO 9EMYG 2.814 Inactive None‑None none-na in-in nonTYR APEdihe_aaiai APEdist_iiii AGS ATPlike 157 - 559 0 None None non-specific serine/threonine protein kinase Plasmodium falciparum
OTHER CK2024380 A0A2I0BRS6_PLAFO 9EMYH 2.814 Inactive None‑None none-na in-in nonTYR APEdihe_aaiai APEdist_iiii AGS ATPlike 158 - 560 0 None None non-specific serine/threonine protein kinase Plasmodium falciparum
OTHER CK2024380 A0A2I0BRS6_PLAFO 9EMYA 2.814 Inactive None‑None none-na in-in nonTYR APEdihe_aaiai APEdist_iiii AGS, PE4 ATPlike, Allosteric 157 - 561 0 None None non-specific serine/threonine protein kinase Plasmodium falciparum
CMGC PHO85 PHO85_YEAST 2PMIA 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oioo AGS ATPlike 19 - 302 0 None None Cyclin-dependent protein kinase PHO85 Saccharomyces cerevisiae
CMGC PHO85 PHO85_YEAST 4KRCA 2.597 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii AGS ATPlike 2 - 302 0 None None Cyclin-dependent protein kinase PHO85 Saccharomyces cerevisiae
OTHER CDC7 CDC7_YEAST 7PT68 3.2 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 10 - 475 0 None None Cell division control protein 7 Saccharomyces cerevisiae
OTHER CDC7 CDC7_YEAST 7PT6H 3.2 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 10 - 475 0 None None Cell division control protein 7 Saccharomyces cerevisiae
OTHER CDC7 CDC7_YEAST 7V3VH 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii AGS ATPlike 12 - 473 0 None None Cell division control protein 7 Saccharomyces cerevisiae

Ligand: AGS

Total number of chains: 36
Active chains: 6
Total number of genes: 9
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 12 33.3% 4Y12A
DFGin BLBminus 10 27.8% 3OROA
DFGin None 6 16.7% 6Z4XB
DFGin ABAminus 4 11.1% 1MRUA
None None 4 11.1% 9EMYB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC CDK7 G0SFC6_CHATD 6Z4XB 2.98 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 78 - 399 0 None None Protein kinase domain-containing protein Chaetomium thermophilum
CMGC CDK7 G0SFC6_CHATD 6Z4XE 2.98 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 77 - 399 0 None None Protein kinase domain-containing protein Chaetomium thermophilum
TYR SRC SRC_CHICK 3DQWA 2.017 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai AGS ATPlike 255 - 533 0 PTR416 T338I Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3DQWB 2.017 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai AGS ATPlike 255 - 533 0 PTR416 T338I Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3DQWC 2.017 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai AGS ATPlike 258 - 533 0 PTR416 T338I Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3DQWD 2.017 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai AGS ATPlike 257 - 533 0 PTR416 T338I Proto-oncogene tyrosine-protein kinase Src Gallus gallus
CMGC MAPK14 MK14_MOUSE 5NZZE 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 4 - 353 0 TPO180,PTR182 None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5NZZF 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 5 - 353 0 TPO180,PTR182 None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5NZZG 2.6 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 5 - 353 0 TPO180,PTR182 None Mitogen-activated protein kinase 14 Mus musculus
CMGC MAPK14 MK14_MOUSE 5NZZH 2.6 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 5 - 352 0 TPO180,PTR182 None Mitogen-activated protein kinase 14 Mus musculus
OTHER PKNB PKNB_MYCTU 1MRUA 3.0 Inactive DFGin‑ABAminus in-in in-none nonTYR APEdihe_aanii APEdist_nnnn AGS ATPlike 3 - 286 0 None None Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNB PKNB_MYCTU 1MRUB 3.0 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn AGS ATPlike 1 - 286 0 None None Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNB PKNB_MYCTU 3ORIA 2.0 Inactive DFGin‑BLBminus in-out out-out nonTYR APEdihe_aaioi APEdist_nnno AGS ATPlike 10 - 290 0 None L33D Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNB PKNB_MYCTU 3ORIB 2.0 Inactive DFGin‑BLBminus in-out out-out nonTYR APEdihe_aaioi APEdist_nnno AGS ATPlike 10 - 290 0 None L33D Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNB PKNB_MYCTU 3ORIC 2.0 Inactive DFGin‑BLBminus in-out out-out nonTYR APEdihe_aaioi APEdist_nnno AGS ATPlike 10 - 290 0 None L33D Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNB PKNB_MYCTU 3ORID 2.0 Inactive DFGin‑BLBminus in-out out-out nonTYR APEdihe_aaioi APEdist_nnno AGS ATPlike 10 - 290 0 None L33D Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNB PKNB_MYCTU 3ORKA 1.6 Inactive DFGin‑BLBminus in-out none-out nonTYR APEdihe_aanoi APEdist_nnnn AGS ATPlike 1 - 290 0 None L33D Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNB PKNB_MYCTU 3ORLA 2.9 Inactive DFGin‑BLBminus in-out none-out nonTYR APEdihe_aanoi APEdist_nnnn AGS ATPlike 3 - 289 0 None L33D Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNB PKNB_MYCTU 3ORPA 2.1 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaioi APEdist_nnoo AGS ATPlike 1 - 290 0 None L33D Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNB PKNB_MYCTU 3ORTA 1.9 Inactive DFGin‑BLBminus out-out out-none nonTYR APEdihe_aannn APEdist_nnnn AGS ATPlike 1 - 289 0 None L33D Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNB PKNB_MYCTU 3ORMA 2.5 Inactive DFGin‑BLBminus in-out out-none nonTYR APEdihe_aanii APEdist_nnnn AGS ATPlike 10 - 289 0 None D76A Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNB PKNB_MYCTU 3OROA 1.9 Inactive DFGin‑BLBminus in-out out-out nonTYR APEdihe_aaooo APEdist_oioo AGS, NHE ATPlike, Allosteric 9 - 288 0 None L33D Serine/threonine-protein kinase PknB Mycobacterium tuberculosis
OTHER PKNG PKNG_MYCTU 4Y12A 1.9 Inactive DFGin‑BLAminus out-none in-out nonTYR APEdihe_aaiii APEdist_oiii AGS ATPlike 83 - 404 0 None None Serine/threonine-protein kinase PknG Mycobacterium tuberculosis
OTHER PAN3 PAN3_NEUCR 4BWKA 3.3 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa AGS ATPlike 235 - 646 0 None None PAN2-PAN3 deadenylation complex subunit pan3 Neurospora crassa
OTHER PAN3 PAN3_NEUCR 4BWKB 3.3 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa AGS ATPlike 235 - 646 0 None None PAN2-PAN3 deadenylation complex subunit pan3 Neurospora crassa
OTHER PAN3 PAN3_NEUCR 4BWXA 2.85 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa AGS ATPlike 234 - 646 0 None L510M,G511P,G512M,T514G,T515A,H516R,L517F PAN2-PAN3 deadenylation complex subunit pan3 Neurospora crassa
OTHER PAN3 PAN3_NEUCR 4BWXB 2.85 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa AGS ATPlike 234 - 646 0 None L510M,G511P,G512M,T514G,T515A,H516R,L517F PAN2-PAN3 deadenylation complex subunit pan3 Neurospora crassa
OTHER CK2024380 A0A2I0BRS6_PLAFO 9EMYB 2.814 Inactive None‑None none-na in-in nonTYR APEdihe_aaiai APEdist_iiii AGS ATPlike 158 - 560 0 None None non-specific serine/threonine protein kinase Plasmodium falciparum
OTHER CK2024380 A0A2I0BRS6_PLAFO 9EMYG 2.814 Inactive None‑None none-na in-in nonTYR APEdihe_aaiai APEdist_iiii AGS ATPlike 157 - 559 0 None None non-specific serine/threonine protein kinase Plasmodium falciparum
OTHER CK2024380 A0A2I0BRS6_PLAFO 9EMYH 2.814 Inactive None‑None none-na in-in nonTYR APEdihe_aaiai APEdist_iiii AGS ATPlike 158 - 560 0 None None non-specific serine/threonine protein kinase Plasmodium falciparum
OTHER CK2024380 A0A2I0BRS6_PLAFO 9EMYA 2.814 Inactive None‑None none-na in-in nonTYR APEdihe_aaiai APEdist_iiii AGS, PE4 ATPlike, Allosteric 157 - 561 0 None None non-specific serine/threonine protein kinase Plasmodium falciparum
CMGC PHO85 PHO85_YEAST 2PMIA 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oioo AGS ATPlike 19 - 302 0 None None Cyclin-dependent protein kinase PHO85 Saccharomyces cerevisiae
CMGC PHO85 PHO85_YEAST 4KRCA 2.597 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii AGS ATPlike 2 - 302 0 None None Cyclin-dependent protein kinase PHO85 Saccharomyces cerevisiae
OTHER CDC7 CDC7_YEAST 7PT68 3.2 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 10 - 475 0 None None Cell division control protein 7 Saccharomyces cerevisiae
OTHER CDC7 CDC7_YEAST 7PT6H 3.2 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii AGS ATPlike 10 - 475 0 None None Cell division control protein 7 Saccharomyces cerevisiae
OTHER CDC7 CDC7_YEAST 7V3VH 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii AGS ATPlike 12 - 473 0 None None Cell division control protein 7 Saccharomyces cerevisiae