TKL_RAF1 (RAF proto-oncogene serine/threonine-protein kinase)

Total number of chains: 32
Active chains: 2
Uniprot: RAF1_HUMAN
Kinase Domain Residues: 349 - 608
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 11 34.4% AF-P04049-K1A
DFGin BLBplus 7 21.9% 9MMQA
DFGin None 5 15.6% 8CHFA
None None 5 15.6% 8GAED
DFGin BLAplus 2 6.2% 9O0VE
DFGin BLBminus 2 6.2% 9O0UC
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-P04049-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 341 - 616 0 None None RAF proto-oncogene serine/threonine-protein kinase
AF-P04049-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 341 - 616 0 None None RAF proto-oncogene serine/threonine-protein kinase
9AYAA 2.59 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaiii APEdist_iioi No_ligand No_ligand 342 - 614 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase
9AYAC 2.59 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo No_ligand No_ligand 341 - 613 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase
9AXAA 4.36 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iioo No_ligand No_ligand 342 - 625 0 SEP621 Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase
9AXAC 4.36 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iioo No_ligand No_ligand 341 - 625 0 SEP621 Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase
9AXCA 4.16 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iioo No_ligand No_ligand 342 - 614 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase
9AXCC 4.16 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iioo No_ligand No_ligand 341 - 614 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase
9O0UG 2.91 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo 324 Type1 341 - 614 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase
9O0VG 3.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo 324 Type1 341 - 614 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase
3OMVB 4.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioo APEdist_nooo SM5 Type1 340 - 615 0 None None RAF proto-oncogene serine/threonine-protein kinase
9O0UE 2.91 Inactive DFGin‑BLAplus out-none none-out nonTYR APEdihe_aaioi APEdist_nnno 324 Type1.5_Back 339 - 613 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase
9O0VE 3.5 Inactive DFGin‑BLAplus out-none none-out nonTYR APEdihe_aaioi APEdist_iioo 324 Type1.5_Back 339 - 613 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase
9O0UC 2.91 Inactive DFGin‑BLBminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo 324 Type1 339 - 614 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase
9O0VC 3.5 Inactive DFGin‑BLBminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo 324 Type1 339 - 614 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase
9AY7A 2.41 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ANP ATPlike 343 - 612 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase
9MMRA 3.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo AGS ATPlike 343 - 625 0 SEP621 Q156R,Y340D,Y341D,D587E RAF proto-oncogene serine/threonine-protein kinase
9MMSA 3.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo AGS ATPlike 343 - 610 0 None Q156R,Y340D,Y341D,D587E RAF proto-oncogene serine/threonine-protein kinase
9MMQA 2.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo AGS ATPlike 341 - 612 0 None Q156R,D587E RAF proto-oncogene serine/threonine-protein kinase
9MMPA 3.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo AGS ATPlike 138 - 630 0 SEP259,SEP621 Q156R,D587E RAF proto-oncogene serine/threonine-protein kinase
9O0UA 2.91 Inactive DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaioi APEdist_oooo 324 Type1.5_Back 339 - 612 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase
9O0VA 3.5 Inactive DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaioi APEdist_oioo 324 Type1.5_Back 339 - 612 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase
8CPDA 3.46 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_nnoo No_ligand No_ligand 341 - 626 0 SEP621 Y341D RAF proto-oncogene serine/threonine-protein kinase
8CPDB 3.46 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_nnoo No_ligand No_ligand 341 - 626 0 SEP621 Y341D RAF proto-oncogene serine/threonine-protein kinase
3OMVA 4.0 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_nioo SM5 Type1 340 - 615 0 None None RAF proto-oncogene serine/threonine-protein kinase
8CHFA 4.25 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaioi APEdist_iiio 29L Type1 341 - 626 0 SEP621 Y341D RAF proto-oncogene serine/threonine-protein kinase
8CHFB 4.25 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaioi APEdist_iiio 29L Type1 341 - 626 0 SEP621 Y341D RAF proto-oncogene serine/threonine-protein kinase
8GFTD 3.8 Inactive None‑None none-none none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 404 - 611 0 None None RAF proto-oncogene serine/threonine-protein kinase
8U1LC 3.7 Inactive None‑None none-none none-out nonTYR APEdihe_aaoii APEdist_nooo No_ligand No_ligand 418 - 615 0 None None RAF proto-oncogene serine/threonine-protein kinase
7Z37CP1 3.67 Inactive None‑None none-none none-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 406 - 615 0 None None RAF proto-oncogene serine/threonine-protein kinase
7Z38C 3.16 Inactive None‑None none-none none-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 406 - 615 0 None None RAF proto-oncogene serine/threonine-protein kinase
8GAED 3.3 Inactive None‑None none-na none-out nonTYR APEdihe_aaioo APEdist_nnno No_ligand No_ligand 404 - 610 0 None None RAF proto-oncogene serine/threonine-protein kinase

TKL_RAF1 (RAF proto-oncogene serine/threonine-protein kinase)

Total number of chains: 32
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 11 34.4% AF-P04049-K1A
DFGin BLBplus 7 21.9% 9MMQA
DFGin None 5 15.6% 8CHFA
None None 5 15.6% 8GAED
DFGin BLAplus 2 6.2% 9O0VE
DFGin BLBminus 2 6.2% 9O0UC
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
RAF1_HUMAN AF-P04049-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 341 - 616 0 None None RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN AF-P04049-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 341 - 616 0 None None RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN 9AYAA 2.59 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaiii APEdist_iioi No_ligand No_ligand 342 - 614 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN 9AYAC 2.59 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo No_ligand No_ligand 341 - 613 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN 9AXAA 4.36 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iioo No_ligand No_ligand 342 - 625 0 SEP621 Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN 9AXAC 4.36 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iioo No_ligand No_ligand 341 - 625 0 SEP621 Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN 9AXCA 4.16 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iioo No_ligand No_ligand 342 - 614 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN 9AXCC 4.16 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iioo No_ligand No_ligand 341 - 614 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN 9O0UG 2.91 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo 324 Type1 341 - 614 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN 9O0VG 3.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo 324 Type1 341 - 614 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN 3OMVB 4.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioo APEdist_nooo SM5 Type1 340 - 615 0 None None RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN 9O0UE 2.91 Inactive DFGin‑BLAplus out-none none-out nonTYR APEdihe_aaioi APEdist_nnno 324 Type1.5_Back 339 - 613 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN 9O0VE 3.5 Inactive DFGin‑BLAplus out-none none-out nonTYR APEdihe_aaioi APEdist_iioo 324 Type1.5_Back 339 - 613 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN 9O0UC 2.91 Inactive DFGin‑BLBminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo 324 Type1 339 - 614 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN 9O0VC 3.5 Inactive DFGin‑BLBminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnoo 324 Type1 339 - 614 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN 9AY7A 2.41 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ANP ATPlike 343 - 612 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN 9MMRA 3.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo AGS ATPlike 343 - 625 0 SEP621 Q156R,Y340D,Y341D,D587E RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN 9MMSA 3.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo AGS ATPlike 343 - 610 0 None Q156R,Y340D,Y341D,D587E RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN 9MMQA 2.9 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo AGS ATPlike 341 - 612 0 None Q156R,D587E RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN 9MMPA 3.4 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo AGS ATPlike 138 - 630 0 SEP259,SEP621 Q156R,D587E RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN 9O0UA 2.91 Inactive DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaioi APEdist_oooo 324 Type1.5_Back 339 - 612 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN 9O0VA 3.5 Inactive DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaioi APEdist_oioo 324 Type1.5_Back 339 - 612 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN 8CPDA 3.46 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_nnoo No_ligand No_ligand 341 - 626 0 SEP621 Y341D RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN 8CPDB 3.46 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaiii APEdist_nnoo No_ligand No_ligand 341 - 626 0 SEP621 Y341D RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN 3OMVA 4.0 Inactive DFGin‑None in-in in-out nonTYR APEdihe_aaioi APEdist_nioo SM5 Type1 340 - 615 0 None None RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN 8CHFA 4.25 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaioi APEdist_iiio 29L Type1 341 - 626 0 SEP621 Y341D RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN 8CHFB 4.25 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaioi APEdist_iiio 29L Type1 341 - 626 0 SEP621 Y341D RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN 8GFTD 3.8 Inactive None‑None none-none none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 404 - 611 0 None None RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN 8U1LC 3.7 Inactive None‑None none-none none-out nonTYR APEdihe_aaoii APEdist_nooo No_ligand No_ligand 418 - 615 0 None None RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN 7Z37CP1 3.67 Inactive None‑None none-none none-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 406 - 615 0 None None RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN 7Z38C 3.16 Inactive None‑None none-none none-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 406 - 615 0 None None RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
RAF1_HUMAN 8GAED 3.3 Inactive None‑None none-na none-out nonTYR APEdihe_aaioo APEdist_nnno No_ligand No_ligand 404 - 610 0 None None RAF proto-oncogene serine/threonine-protein kinase Homo sapiens

TKL_RAF1 (RAF proto-oncogene serine/threonine-protein kinase)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism