RAF1 (RAF proto-oncogene serine/threonine-protein kinase)

Group: TKL

Uniprot: RAF1_HUMAN

Domain boundary: 349 - 608

Total number of chains: 19

Spatial	Dihedral	Chains	Representative
DFGin	BLAminus	8	AF-P04049-K1A
DFGin	BLBplus	1	9AY7A
DFGin	None	5	8CHFA
None	None	5	8GAED

Database table as tsv

PDB	Resolution	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type	Residues in structure	Mutation	Phosphorylation	Unresolved residues in A-loop
AF-P04049-K1A	-1.0	Active	DFGin	BLAminus	in-in	in-in	No_ligand	No_ligand	341 - 616	None	None	0
9AYAA	2.59	None	DFGin	BLAminus	in-none	in-in	No_ligand	No_ligand	342 - 614	Y340D,Y341D	None	0
9AYAC	2.59	Inactive	DFGin	BLAminus	in-in	in-out	No_ligand	No_ligand	341 - 613	Y340D,Y341D	None	0
9AXAA	4.36	Inactive	DFGin	BLAminus	in-out	in-out	No_ligand	No_ligand	342 - 625	Y340D,Y341D	X621	5
9AXAC	4.36	Inactive	DFGin	BLAminus	in-out	in-out	No_ligand	No_ligand	341 - 625	Y340D,Y341D	X621	0
9AXCA	4.16	Inactive	DFGin	BLAminus	in-out	in-out	No_ligand	No_ligand	342 - 614	Y340D,Y341D	None	5
9AXCC	4.16	Inactive	DFGin	BLAminus	in-out	in-out	No_ligand	No_ligand	341 - 614	Y340D,Y341D	None	0
3OMVB	4.0	Inactive	DFGin	BLAminus	in-in	in-out	SM5	Type1	340 - 615	None	None	12
9AY7A	2.41	Inactive	DFGin	BLBplus	out-out	out-out	ANP	Type1	343 - 612	Y340D,Y341D	None	6
8CPDA	3.46	Inactive	DFGin	None	in-in	in-out	No_ligand	No_ligand	341 - 626	Y341D	X621	12
8CPDB	3.46	Inactive	DFGin	None	in-in	in-out	No_ligand	No_ligand	341 - 626	Y341D	X621	12
3OMVA	4.0	Inactive	DFGin	None	in-in	in-out	SM5	Type1	340 - 615	None	None	12
8CHFA	4.25	Inactive	DFGin	None	in-out	in-out	29L	Type1	341 - 626	Y341D	X621	6
8CHFB	4.25	Inactive	DFGin	None	in-out	in-out	29L	Type1	341 - 626	Y341D	X621	6
8GFTD	3.8	Inactive	None	None	none-none	none-out	No_ligand	No_ligand	404 - 611	None	None	17
8U1LC	3.7	Inactive	None	None	none-none	none-out	No_ligand	No_ligand	418 - 615	None	None	14
7Z37CP1	3.67	Inactive	None	None	none-none	none-none	No_ligand	No_ligand	406 - 615	None	None	17
7Z38C	3.16	Inactive	None	None	none-none	none-none	No_ligand	No_ligand	406 - 615	None	None	17
8GAED	3.3	Inactive	None	None	none-none	none-out	No_ligand	No_ligand	404 - 610	None	None	18

RAF1 (RAF proto-oncogene serine/threonine-protein kinase)

Group: TKL

Total number of chains: 19

Spatial	Dihedral	Chains	Representative
DFGin	BLAminus	8	AF-P04049-K1A
DFGin	BLBplus	1	9AY7A
DFGin	None	5	8CHFA
None	None	5	8GAED

Database table as tsv

Organism	UniprotID	PDB	Resolution	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type	Residues in structure	Mutation	Phosphorylation	Unresolved residues in A-loop
Homo sapiens	RAF1_HUMAN	AF-P04049-K1A	-1.0	Active	DFGin	BLAminus	in-in	in-in	No_ligand	No_ligand	341 - 616	None	None	0
Homo sapiens	RAF1_HUMAN	9AYAA	2.59	None	DFGin	BLAminus	in-none	in-in	No_ligand	No_ligand	342 - 614	Y340D,Y341D	None	0
Homo sapiens	RAF1_HUMAN	9AYAC	2.59	Inactive	DFGin	BLAminus	in-in	in-out	No_ligand	No_ligand	341 - 613	Y340D,Y341D	None	0
Homo sapiens	RAF1_HUMAN	9AXAA	4.36	Inactive	DFGin	BLAminus	in-out	in-out	No_ligand	No_ligand	342 - 625	Y340D,Y341D	X621	5
Homo sapiens	RAF1_HUMAN	9AXAC	4.36	Inactive	DFGin	BLAminus	in-out	in-out	No_ligand	No_ligand	341 - 625	Y340D,Y341D	X621	0
Homo sapiens	RAF1_HUMAN	9AXCA	4.16	Inactive	DFGin	BLAminus	in-out	in-out	No_ligand	No_ligand	342 - 614	Y340D,Y341D	None	5
Homo sapiens	RAF1_HUMAN	9AXCC	4.16	Inactive	DFGin	BLAminus	in-out	in-out	No_ligand	No_ligand	341 - 614	Y340D,Y341D	None	0
Homo sapiens	RAF1_HUMAN	3OMVB	4.0	Inactive	DFGin	BLAminus	in-in	in-out	SM5	Type1	340 - 615	None	None	12
Homo sapiens	RAF1_HUMAN	9AY7A	2.41	Inactive	DFGin	BLBplus	out-out	out-out	ANP	Type1	343 - 612	Y340D,Y341D	None	6
Homo sapiens	RAF1_HUMAN	8CPDA	3.46	Inactive	DFGin	None	in-in	in-out	No_ligand	No_ligand	341 - 626	Y341D	X621	12
Homo sapiens	RAF1_HUMAN	8CPDB	3.46	Inactive	DFGin	None	in-in	in-out	No_ligand	No_ligand	341 - 626	Y341D	X621	12
Homo sapiens	RAF1_HUMAN	3OMVA	4.0	Inactive	DFGin	None	in-in	in-out	SM5	Type1	340 - 615	None	None	12
Homo sapiens	RAF1_HUMAN	8CHFA	4.25	Inactive	DFGin	None	in-out	in-out	29L	Type1	341 - 626	Y341D	X621	6
Homo sapiens	RAF1_HUMAN	8CHFB	4.25	Inactive	DFGin	None	in-out	in-out	29L	Type1	341 - 626	Y341D	X621	6
Homo sapiens	RAF1_HUMAN	8GFTD	3.8	Inactive	None	None	none-none	none-out	No_ligand	No_ligand	404 - 611	None	None	17
Homo sapiens	RAF1_HUMAN	8U1LC	3.7	Inactive	None	None	none-none	none-out	No_ligand	No_ligand	418 - 615	None	None	14
Homo sapiens	RAF1_HUMAN	7Z37CP1	3.67	Inactive	None	None	none-none	none-none	No_ligand	No_ligand	406 - 615	None	None	17
Homo sapiens	RAF1_HUMAN	7Z38C	3.16	Inactive	None	None	none-none	none-none	No_ligand	No_ligand	406 - 615	None	None	17
Homo sapiens	RAF1_HUMAN	8GAED	3.3	Inactive	None	None	none-none	none-out	No_ligand	No_ligand	404 - 610	None	None	18

RAF1 (RAF proto-oncogene serine/threonine-protein kinase)

No non-human structures known.