RAF1 (RAF proto-oncogene serine/threonine-protein kinase)

Group: TKL
Uniprot: RAF1_HUMAN
Domain boundary: 349 - 608


Total number of chains: 31
Spatial Dihedral Chains Representative
DFGin BLAminus 10 AF-P04049-K1A
DFGin BLAplus 2 9O0VE
DFGin BLBminus 2 9O0UC
DFGin BLBplus 7 9MMQA
DFGin None 5 8CHFA
None None 5 8GAED
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-P04049-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 341 - 616 None None 0
9AYAA 2.59 None DFGin BLAminus in-none in-in No_ligand No_ligand 342 - 614 Y340D,Y341D None 0
9AYAC 2.59 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 341 - 613 Y340D,Y341D None 0
9AXAA 4.36 Inactive DFGin BLAminus in-out in-out No_ligand No_ligand 342 - 625 Y340D,Y341D X621 5
9AXAC 4.36 Inactive DFGin BLAminus in-out in-out No_ligand No_ligand 341 - 625 Y340D,Y341D X621 0
9AXCA 4.16 Inactive DFGin BLAminus in-out in-out No_ligand No_ligand 342 - 614 Y340D,Y341D None 5
9AXCC 4.16 Inactive DFGin BLAminus in-out in-out No_ligand No_ligand 341 - 614 Y340D,Y341D None 0
9O0UG 2.91 Inactive DFGin BLAminus in-in in-out 324 Type1 341 - 614 Y340D,Y341D None 9
9O0VG 3.5 Inactive DFGin BLAminus in-in in-out 324 Type1 341 - 614 Y340D,Y341D None 9
3OMVB 4.0 Inactive DFGin BLAminus in-in in-out SM5 Type1 340 - 615 None None 12
9O0UE 2.91 Inactive DFGin BLAplus out-none none-out 324 Type1.5_Back 339 - 613 Y340D,Y341D None 17
9O0VE 3.5 Inactive DFGin BLAplus out-none none-out 324 Type1.5_Back 339 - 613 Y340D,Y341D None 14
9O0UC 2.91 Inactive DFGin BLBminus in-in in-out 324 Type1 339 - 614 Y340D,Y341D None 12
9O0VC 3.5 Inactive DFGin BLBminus in-in in-out 324 Type1 339 - 614 Y340D,Y341D None 12
9AY7A 2.41 Inactive DFGin BLBplus out-out out-out ANP Type1 343 - 612 Y340D,Y341D None 6
9MMRA 3.9 Inactive DFGin BLBplus out-out out-out AGS Type1 343 - 625 Q156R,Y340D,Y341D,D587E X621 0
9MMSA 3.3 Inactive DFGin BLBplus out-out out-out AGS Type1 343 - 610 Q156R,Y340D,Y341D,D587E None 0
9MMQA 2.9 Inactive DFGin BLBplus out-out out-out AGS Type1 341 - 612 Q156R,D587E None 0
9MMPA 3.4 Inactive DFGin BLBplus out-out out-out AGS Type1 138 - 630 Q156R,D587E X259,X621 0
9O0UA 2.91 Inactive DFGin BLBplus out-none out-out 324 Type1.5_Back 339 - 612 Y340D,Y341D None 7
9O0VA 3.5 Inactive DFGin BLBplus out-none out-out 324 Type1.5_Back 339 - 612 Y340D,Y341D None 8
8CPDA 3.46 Inactive DFGin None in-in in-out No_ligand No_ligand 341 - 626 Y341D X621 12
8CPDB 3.46 Inactive DFGin None in-in in-out No_ligand No_ligand 341 - 626 Y341D X621 12
3OMVA 4.0 Inactive DFGin None in-in in-out SM5 Type1 340 - 615 None None 12
8CHFA 4.25 Inactive DFGin None in-out in-out 29L Type1 341 - 626 Y341D X621 6
8CHFB 4.25 Inactive DFGin None in-out in-out 29L Type1 341 - 626 Y341D X621 6
8GFTD 3.8 Inactive None None none-none none-out No_ligand No_ligand 404 - 611 None None 17
8U1LC 3.7 Inactive None None none-none none-out No_ligand No_ligand 418 - 615 None None 14
7Z37CP1 3.67 Inactive None None none-none none-none No_ligand No_ligand 406 - 615 None None 17
7Z38C 3.16 Inactive None None none-none none-none No_ligand No_ligand 406 - 615 None None 17
8GAED 3.3 Inactive None None none-none none-out No_ligand No_ligand 404 - 610 None None 18

RAF1 (RAF proto-oncogene serine/threonine-protein kinase)

Group: TKL
Total number of chains: 31
Spatial Dihedral Chains Representative
DFGin BLAminus 10 AF-P04049-K1A
DFGin BLAplus 2 9O0VE
DFGin BLBminus 2 9O0UC
DFGin BLBplus 7 9MMQA
DFGin None 5 8CHFA
None None 5 8GAED
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens RAF1_HUMAN AF-P04049-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 341 - 616 None None 0
Homo sapiens RAF1_HUMAN 9AYAA 2.59 None DFGin BLAminus in-none in-in No_ligand No_ligand 342 - 614 Y340D,Y341D None 0
Homo sapiens RAF1_HUMAN 9AYAC 2.59 Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 341 - 613 Y340D,Y341D None 0
Homo sapiens RAF1_HUMAN 9AXAA 4.36 Inactive DFGin BLAminus in-out in-out No_ligand No_ligand 342 - 625 Y340D,Y341D X621 5
Homo sapiens RAF1_HUMAN 9AXAC 4.36 Inactive DFGin BLAminus in-out in-out No_ligand No_ligand 341 - 625 Y340D,Y341D X621 0
Homo sapiens RAF1_HUMAN 9AXCA 4.16 Inactive DFGin BLAminus in-out in-out No_ligand No_ligand 342 - 614 Y340D,Y341D None 5
Homo sapiens RAF1_HUMAN 9AXCC 4.16 Inactive DFGin BLAminus in-out in-out No_ligand No_ligand 341 - 614 Y340D,Y341D None 0
Homo sapiens RAF1_HUMAN 9O0UG 2.91 Inactive DFGin BLAminus in-in in-out 324 Type1 341 - 614 Y340D,Y341D None 9
Homo sapiens RAF1_HUMAN 9O0VG 3.5 Inactive DFGin BLAminus in-in in-out 324 Type1 341 - 614 Y340D,Y341D None 9
Homo sapiens RAF1_HUMAN 3OMVB 4.0 Inactive DFGin BLAminus in-in in-out SM5 Type1 340 - 615 None None 12
Homo sapiens RAF1_HUMAN 9O0UE 2.91 Inactive DFGin BLAplus out-none none-out 324 Type1.5_Back 339 - 613 Y340D,Y341D None 17
Homo sapiens RAF1_HUMAN 9O0VE 3.5 Inactive DFGin BLAplus out-none none-out 324 Type1.5_Back 339 - 613 Y340D,Y341D None 14
Homo sapiens RAF1_HUMAN 9O0UC 2.91 Inactive DFGin BLBminus in-in in-out 324 Type1 339 - 614 Y340D,Y341D None 12
Homo sapiens RAF1_HUMAN 9O0VC 3.5 Inactive DFGin BLBminus in-in in-out 324 Type1 339 - 614 Y340D,Y341D None 12
Homo sapiens RAF1_HUMAN 9AY7A 2.41 Inactive DFGin BLBplus out-out out-out ANP Type1 343 - 612 Y340D,Y341D None 6
Homo sapiens RAF1_HUMAN 9MMRA 3.9 Inactive DFGin BLBplus out-out out-out AGS Type1 343 - 625 Q156R,Y340D,Y341D,D587E X621 0
Homo sapiens RAF1_HUMAN 9MMSA 3.3 Inactive DFGin BLBplus out-out out-out AGS Type1 343 - 610 Q156R,Y340D,Y341D,D587E None 0
Homo sapiens RAF1_HUMAN 9MMQA 2.9 Inactive DFGin BLBplus out-out out-out AGS Type1 341 - 612 Q156R,D587E None 0
Homo sapiens RAF1_HUMAN 9MMPA 3.4 Inactive DFGin BLBplus out-out out-out AGS Type1 138 - 630 Q156R,D587E X259,X621 0
Homo sapiens RAF1_HUMAN 9O0UA 2.91 Inactive DFGin BLBplus out-none out-out 324 Type1.5_Back 339 - 612 Y340D,Y341D None 7
Homo sapiens RAF1_HUMAN 9O0VA 3.5 Inactive DFGin BLBplus out-none out-out 324 Type1.5_Back 339 - 612 Y340D,Y341D None 8
Homo sapiens RAF1_HUMAN 8CPDA 3.46 Inactive DFGin None in-in in-out No_ligand No_ligand 341 - 626 Y341D X621 12
Homo sapiens RAF1_HUMAN 8CPDB 3.46 Inactive DFGin None in-in in-out No_ligand No_ligand 341 - 626 Y341D X621 12
Homo sapiens RAF1_HUMAN 3OMVA 4.0 Inactive DFGin None in-in in-out SM5 Type1 340 - 615 None None 12
Homo sapiens RAF1_HUMAN 8CHFA 4.25 Inactive DFGin None in-out in-out 29L Type1 341 - 626 Y341D X621 6
Homo sapiens RAF1_HUMAN 8CHFB 4.25 Inactive DFGin None in-out in-out 29L Type1 341 - 626 Y341D X621 6
Homo sapiens RAF1_HUMAN 8GFTD 3.8 Inactive None None none-none none-out No_ligand No_ligand 404 - 611 None None 17
Homo sapiens RAF1_HUMAN 8U1LC 3.7 Inactive None None none-none none-out No_ligand No_ligand 418 - 615 None None 14
Homo sapiens RAF1_HUMAN 7Z37CP1 3.67 Inactive None None none-none none-none No_ligand No_ligand 406 - 615 None None 17
Homo sapiens RAF1_HUMAN 7Z38C 3.16 Inactive None None none-none none-none No_ligand No_ligand 406 - 615 None None 17
Homo sapiens RAF1_HUMAN 8GAED 3.3 Inactive None None none-none none-out No_ligand No_ligand 404 - 610 None None 18

RAF1 (RAF proto-oncogene serine/threonine-protein kinase)

No non-human structures known.