TYR_MET (Hepatocyte growth factor receptor)

Total number of chains: 126
Active chains: 2
Uniprot: MET_HUMAN
Kinase Domain Residues: 1076 - 1339
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 75 59.5% 3DKCA
DFGout BBAminus 31 24.6% 8OUUB
DFGout None 7 5.6% 3RHKA
None None 4 3.2% 3EFJB
DFGin ABAminus 3 2.4% 3Q6WA
DFGin BLAminus 2 1.6% AF-P08581-K1A
DFGin None 2 1.6% 3EFKA
DFGin BLBminus 1 0.8% 3Q6UA
DFGin BLBtrans 1 0.8% 5HLWA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-P08581-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1068 - 1347 0 None None Hepatocyte growth factor receptor
AF-P08581-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1068 - 1347 0 None None Hepatocyte growth factor receptor
4IWDA 1.99 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai AME, 1JC Allosteric, Type1 1048 - 1348 0 PTR1234,PTR1235 None Hepatocyte growth factor receptor
3Q6WA 1.75 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai Q6W Type1 1050 - 1348 0 PTR1234,PTR1235 None Hepatocyte growth factor receptor
3R7OA 2.3 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai M61 Type1 1048 - 1348 0 PTR1234,PTR1235 None Hepatocyte growth factor receptor
3Q6UA 1.6 Inactive DFGin‑BLBminus in-out none-none TYR APEdihe_nniai APEdist_aaai AME Allosteric 1048 - 1348 0 None None Hepatocyte growth factor receptor
3DKCA 1.52 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao ATP ATPlike 1051 - 1360 0 None Y1194F,Y1234F,Y1235D Hepatocyte growth factor receptor
2G15A 2.15 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1046 - 1346 0 None None Hepatocyte growth factor receptor
1R1WA 1.8 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai No_ligand No_ligand 1050 - 1360 0 None Y1194F,Y1234F,Y1235D,L1272L Hepatocyte growth factor receptor
8AU3A 2.26 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nnoai APEdist_aaao 3E8 Type1 1052 - 1349 0 None Y1234E,Y1235E Hepatocyte growth factor receptor
8AU3B 2.26 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nnoai APEdist_aaao 3E8 Type1 1056 - 1349 0 None Y1234E,Y1235E Hepatocyte growth factor receptor
8AU5A 2.72 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 3E8 Type1 1067 - 1346 0 None F1200I Hepatocyte growth factor receptor
8AW1A 2.14 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_niiai APEdist_aaai 3E8 Type1 1066 - 1345 0 None Y1235D Hepatocyte growth factor receptor
8AW1B 2.14 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 3E8 Type1 1064 - 1345 0 None Y1235D Hepatocyte growth factor receptor
4KNBA 2.4 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 1RU Type1 1064 - 1344 0 None None Hepatocyte growth factor receptor
4KNBB 2.4 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai 1RU Type1 1067 - 1346 0 None None Hepatocyte growth factor receptor
4KNBC 2.4 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 1RU Type1 1060 - 1346 0 None None Hepatocyte growth factor receptor
4KNBD 2.4 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nnnan APEdist_aaan 1RU Type1 1064 - 1346 0 None None Hepatocyte growth factor receptor
4R1VA 1.2 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 3E8 Type1 1055 - 1345 0 None None Hepatocyte growth factor receptor
2WD1A 2.0 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai ZZY Type1 1055 - 1346 0 None None Hepatocyte growth factor receptor
4R1YA 2.0 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 3EH Type1 1062 - 1346 0 None None Hepatocyte growth factor receptor
3F66A 1.4 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai IHX Type1 1052 - 1349 0 None None Hepatocyte growth factor receptor
3F66B 1.4 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai IHX Type1 1062 - 1349 0 None None Hepatocyte growth factor receptor
7B3QA 1.75 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nnnai APEdist_aaan SV5 Type1 1055 - 1344 0 None None Hepatocyte growth factor receptor
7B3TA 2.23 Inactive DFGin‑BLBplus out-none out-none TYR APEdihe_nniai APEdist_aaai SVK Type1 1062 - 1344 0 None None Hepatocyte growth factor receptor
7B3VA 1.93 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai SWB Type1 1057 - 1344 0 None None Hepatocyte growth factor receptor
7B3WA 2.02 Inactive DFGin‑BLBplus none-none out-in TYR APEdihe_iiiai APEdist_aaai SVH Type1 1067 - 1344 0 None None Hepatocyte growth factor receptor
7B3ZA 1.8 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nnnai APEdist_aaan SV8 Type1 1055 - 1344 0 None None Hepatocyte growth factor receptor
7B40A 1.76 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nnnai APEdist_aaan SWN Type1 1055 - 1346 0 None None Hepatocyte growth factor receptor
7B41A 1.97 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai SWK Type1 1055 - 1346 0 None None Hepatocyte growth factor receptor
7B42A 1.8 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai SW8 Type1 1055 - 1344 0 None None Hepatocyte growth factor receptor
7B43A 1.87 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nnnai APEdist_aaan SW5 Type1 1055 - 1344 0 None None Hepatocyte growth factor receptor
7B43B 1.87 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nnnai APEdist_aaan SW5 Type1 1055 - 1346 0 None None Hepatocyte growth factor receptor
7B44A 1.76 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nnnai APEdist_aaan SVT Type1 1055 - 1346 0 None None Hepatocyte growth factor receptor
2WGJA 2.0 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai VGH Type1 1052 - 1345 0 None None Hepatocyte growth factor receptor
2WKMA 2.2 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai PFY Type1 1059 - 1345 0 None None Hepatocyte growth factor receptor
3ZBXA 2.2 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 6XE Type1 1059 - 1345 0 None None Hepatocyte growth factor receptor
3ZC5A 2.2 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai W9Z Type1 1052 - 1345 0 None None Hepatocyte growth factor receptor
3ZCLA 1.4 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 5TF Type1 1052 - 1345 0 None None Hepatocyte growth factor receptor
3ZXZA 1.8 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai KRW Type1 1052 - 1345 0 None None Hepatocyte growth factor receptor
3ZZEA 1.87 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 6XP Type1 1059 - 1345 0 None None Hepatocyte growth factor receptor
4AOIA 1.9 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 4K0 Type1 1052 - 1344 0 None None Hepatocyte growth factor receptor
4AP7A 1.8 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai F47 Type1 1052 - 1345 0 None None Hepatocyte growth factor receptor
6SDEA 2.49 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai V0L Type1 1068 - 1346 0 None None Hepatocyte growth factor receptor
7Y4TA 2.16 Inactive DFGin‑BLBplus out-none out-in TYR APEdihe_iiiai APEdist_aaai I90 Type1 1063 - 1345 0 None None Hepatocyte growth factor receptor
7Y4UA 2.26 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai I94 Type1 1061 - 1344 0 None None Hepatocyte growth factor receptor
8GVJA 2.71 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai KGL Type1 1060 - 1344 0 None None Hepatocyte growth factor receptor
8K78A 2.67 Inactive DFGin‑BLBplus out-none out-in TYR APEdihe_iiiai APEdist_aaai IYC Type1 1048 - 1345 0 None None Hepatocyte growth factor receptor
9IVBA 2.35 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai A1L3A Type1 1040 - 1344 0 None None Hepatocyte growth factor receptor
9IVBB 2.35 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai A1L3A Type1 1045 - 1344 0 None None Hepatocyte growth factor receptor
3I5NA 2.0 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_niiai APEdist_aaai B2D Type1 1052 - 1346 0 None None Hepatocyte growth factor receptor
4DEGA 2.0 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 0JJ Type1 1052 - 1346 0 None None Hepatocyte growth factor receptor
4DEHA 2.0 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 0JK Type1 1053 - 1346 0 None None Hepatocyte growth factor receptor
4DEIA 2.05 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 0JL Type1 1053 - 1346 0 None None Hepatocyte growth factor receptor
4XMOA 1.75 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 46G Type1 1051 - 1345 0 None None Hepatocyte growth factor receptor
4XYFA 1.85 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 44X Type1 1052 - 1346 0 None None Hepatocyte growth factor receptor
5EYCA 1.8 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 5SZ Type1 1053 - 1345 0 None None Hepatocyte growth factor receptor
5EYDA 1.85 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 5T1 Type1 1052 - 1348 0 None None Hepatocyte growth factor receptor
2RFSA 2.2 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai AM8 Type1 1067 - 1346 0 None None Hepatocyte growth factor receptor
3CCNA 1.9 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai LKG Type1 1055 - 1346 0 None None Hepatocyte growth factor receptor
3CD8A 2.0 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai L5G Type1 1054 - 1346 0 None None Hepatocyte growth factor receptor
4GG5A 2.423 Inactive DFGin‑BLBplus out-none out-in TYR APEdihe_iiiai APEdist_aaai 0J3 Type1 1064 - 1344 0 None None Hepatocyte growth factor receptor
4GG7A 2.27 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 0J8 Type1 1064 - 1344 0 None None Hepatocyte growth factor receptor
5EOBA 1.75 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 5QQ Type1 1055 - 1345 0 None None Hepatocyte growth factor receptor
5YA5A 1.89 Inactive DFGin‑BLBplus out-none out-in TYR APEdihe_iiiai APEdist_aaai 6TD Type1 1057 - 1345 0 None None Hepatocyte growth factor receptor
5UABA 1.9 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 84M Type1 1029 - 1360 0 None None Hepatocyte growth factor receptor
5UADA 2.25 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 84P Type1 1029 - 1360 0 None None Hepatocyte growth factor receptor
6UBWA 2.0 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 84S Type1 1029 - 1360 0 None None Hepatocyte growth factor receptor
3DKGA 1.91 Inactive DFGin‑BLBplus out-none out-none TYR APEdihe_nniai APEdist_aaai SX8 Type1 1050 - 1356 0 None Y1194F,Y1230L,Y1234F,Y1235D Hepatocyte growth factor receptor
1R0PA 1.8 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao KSA Type1 1050 - 1360 0 None Y1194F,Y1234F,Y1235D,L1272L Hepatocyte growth factor receptor
5HNIX 1.71 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nnnan APEdist_aaan 63B Type1 1063 - 1356 0 None None Hepatocyte growth factor receptor
5HNIY 1.71 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nnnan APEdist_aaan 63B Type1 1063 - 1356 0 None None Hepatocyte growth factor receptor
5HO6A 1.97 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai 63K Type1 1063 - 1356 0 None Y1194F,Y1234F,Y1235D Hepatocyte growth factor receptor
3QTIA 2.0 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao 3QT Type1 1052 - 1360 0 None Y1194F,Y1234F,Y1235D Hepatocyte growth factor receptor
3QTIB 2.0 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao 3QT Type1 1058 - 1360 0 None Y1194F,Y1234F,Y1235D Hepatocyte growth factor receptor
3DKFA 1.8 Inactive DFGin‑BLBplus out-none out-none TYR APEdihe_niiai APEdist_aaai SX8 Type1 1050 - 1360 0 None Y1194F,Y1234F,Y1235D Hepatocyte growth factor receptor
3A4PA 2.54 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaai DFQ Type1 1063 - 1360 0 None Y1194F,Y1234F,Y1235D Hepatocyte growth factor receptor
5HOAA 2.14 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai 63K Type1 1065 - 1356 0 None None Hepatocyte growth factor receptor
5HORA 2.2 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao 63K Type1 1064 - 1356 0 None Y1194F,Y1234F,Y1235D,M1250T Hepatocyte growth factor receptor
3U6HA 2.0 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan 03X Type1.5_Front 1051 - 1351 0 None None Hepatocyte growth factor receptor
3U6IA 2.1 Inactive DFGin‑BLBplus out-out none-out TYR APEdihe_nniai APEdist_aaao 044 Type1.5_Front 1051 - 1351 0 None None Hepatocyte growth factor receptor
5HLWA 1.97 Inactive DFGin‑BLBtrans out-out out-in TYR APEdihe_iiiai APEdist_aaai 62E Type1 1057 - 1355 0 None Y1230H Hepatocyte growth factor receptor
3EFKA 2.2 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan MT4 Type1.5_Front 1054 - 1351 0 None L1272L Hepatocyte growth factor receptor
3EFKB 2.2 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan MT4 Type1.5_Front 1054 - 1351 0 None L1272L Hepatocyte growth factor receptor
3RHKB 1.94 Inactive DFGout‑BBAminus out-none out-in TYR APEdihe_iiiai APEdist_aaai M97 Type1 1046 - 1344 0 None None Hepatocyte growth factor receptor
8ANSA 2.01 Inactive DFGout‑BBAminus out-none in-none TYR APEdihe_nniai APEdist_aaai MDI Type1.5_Front 1052 - 1346 0 None D1228V Hepatocyte growth factor receptor
8VI1A 3.11 Inactive DFGout‑BBAminus out-out out-out TYR APEdihe_iiiai APEdist_aaao A1AB1 Type1.5_Front 1053 - 1346 0 None None Hepatocyte growth factor receptor
8VI1B 3.11 Inactive DFGout‑BBAminus out-out out-in TYR APEdihe_iiiai APEdist_aaai A1AB1 Type1.5_Front 1050 - 1345 0 None None Hepatocyte growth factor receptor
8AN8A 2.394 Inactive DFGout‑BBAminus out-out in-none TYR APEdihe_nnnai APEdist_aaan MDI Type1.5_Front 1073 - 1345 0 None None Hepatocyte growth factor receptor
8AN8B 2.394 Inactive DFGout‑BBAminus out-out in-none TYR APEdihe_nniai APEdist_aaai MDI Type1.5_Front 1058 - 1345 0 None None Hepatocyte growth factor receptor
6SDCA 1.67 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 88Z Type2 1052 - 1346 0 None D1228V Hepatocyte growth factor receptor
6SDDA 1.93 Inactive DFGout‑BBAminus out-out out-in TYR APEdihe_iiiai APEdist_aaai 353 Type2 1062 - 1344 0 None D1228V Hepatocyte growth factor receptor
9C1RA 1.59 Inactive DFGout‑BBAminus in-out none-none TYR APEdihe_nnnai APEdist_aaan A1ATS Type2 1048 - 1348 0 None D1228N Hepatocyte growth factor receptor
3LQ8A 2.02 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 88Z Type2 1053 - 1345 0 None None Hepatocyte growth factor receptor
6SD9A 2.35 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 88Z Type2 1062 - 1345 0 None None Hepatocyte growth factor receptor
4EEVA 1.8 Inactive DFGout‑BBAminus in-out none-none TYR APEdihe_niiai APEdist_aaai L1X Type2 1045 - 1346 0 None None Hepatocyte growth factor receptor
4MXCA 1.632 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai DWF Type2 1052 - 1346 0 None None Hepatocyte growth factor receptor
5HTIA 1.66 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 66L Type2 1052 - 1346 0 None None Hepatocyte growth factor receptor
7V3SA 1.9 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 5I9 Type2 1053 - 1346 0 None None Hepatocyte growth factor receptor
3VW8A 2.1 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai DF6 Type2 1024 - 1352 0 None None Hepatocyte growth factor receptor
3CE3A 2.4 Inactive DFGout‑BBAminus out-out none-out TYR APEdihe_oiiai APEdist_aaai 1FN Type2 1054 - 1360 0 None Y1194F,Y1234F,Y1235D,L1272L Hepatocyte growth factor receptor
3CTHA 2.3 Inactive DFGout‑BBAminus out-out none-out TYR APEdihe_oiiai APEdist_aaai 319 Type2 1052 - 1360 0 None Y1194F,Y1234F,Y1235D Hepatocyte growth factor receptor
3F82A 2.5 Inactive DFGout‑BBAminus out-out none-none TYR APEdihe_niiai APEdist_aaai 353 Type2 1055 - 1360 0 None Y1194F,Y1234F,Y1235D Hepatocyte growth factor receptor
3L8VA 2.4 Inactive DFGout‑BBAminus in-out none-out TYR APEdihe_oiiai APEdist_aaai L8V Type2 1054 - 1360 0 None Y1194F,Y1234F,Y1235D Hepatocyte growth factor receptor
8OUUA 1.77 Inactive DFGout‑BBAminus out-out out-in TYR APEdihe_iiiai APEdist_aaai W49 Type3 1059 - 1346 0 None D1228V Hepatocyte growth factor receptor
8OUUB 1.77 Inactive DFGout‑BBAminus out-out out-out TYR APEdihe_iiiai APEdist_aaao W49 Type3 1057 - 1346 0 None D1228V Hepatocyte growth factor receptor
8OUVA 1.783 Inactive DFGout‑BBAminus out-out out-out TYR APEdihe_iiiai APEdist_aaao W3R Type3 1053 - 1346 0 None D1228V Hepatocyte growth factor receptor
8OUVB 1.783 Inactive DFGout‑BBAminus out-out out-out TYR APEdihe_iiiai APEdist_aaao W3R Type3 1057 - 1346 0 None D1228V Hepatocyte growth factor receptor
8OV7A 1.95 Inactive DFGout‑BBAminus out-out out-out TYR APEdihe_iioai APEdist_aaao W3W Type3 1051 - 1346 0 None D1228V Hepatocyte growth factor receptor
8OVZA 2.206 Inactive DFGout‑BBAminus out-out out-out TYR APEdihe_iiiai APEdist_aaao W3N Type3 1061 - 1346 0 None D1228V Hepatocyte growth factor receptor
8OVZB 2.206 Inactive DFGout‑BBAminus out-out out-out TYR APEdihe_iiiai APEdist_aaao W3N Type3 1057 - 1346 0 None D1228V Hepatocyte growth factor receptor
8OWGA 2.631 Inactive DFGout‑BBAminus out-none out-none TYR APEdihe_nnnai APEdist_aaan W40 Type3 1060 - 1344 0 None D1228V Hepatocyte growth factor receptor
8OWGB 2.631 Inactive DFGout‑BBAminus out-none out-in TYR APEdihe_iiiai APEdist_aaai W40 Type3 1060 - 1343 0 None D1228V Hepatocyte growth factor receptor
8OWGC 2.631 Inactive DFGout‑BBAminus out-none none-out TYR APEdihe_nniai APEdist_aaao W40 Type3 1060 - 1343 0 None D1228V Hepatocyte growth factor receptor
8OW3A 2.27 Inactive DFGout‑BBAminus out-none none-none TYR APEdihe_nniai APEdist_aaai W40 Type3 1058 - 1345 0 None None Hepatocyte growth factor receptor
3RHKA 1.94 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai M97 Type1 1049 - 1346 0 None None Hepatocyte growth factor receptor
3EFJA 2.6 Inactive DFGout‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan MT3 Type1.5_Front 1054 - 1351 0 None L1272L Hepatocyte growth factor receptor
5DG5A 2.6 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 5B4 Type2 1050 - 1346 0 None None Hepatocyte growth factor receptor
5DG5B 2.6 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 5B4 Type2 1050 - 1346 0 None None Hepatocyte growth factor receptor
7V3RA 1.7 Inactive DFGout‑None in-out out-none TYR APEdihe_nniai APEdist_aaai 5IE Type2 1053 - 1346 0 None None Hepatocyte growth factor receptor
3CTJA 2.5 Inactive DFGout‑None in-in none-none TYR APEdihe_nniai APEdist_aaai 320 Type2 1051 - 1360 0 None Y1194F,Y1234F,Y1235D Hepatocyte growth factor receptor
3C1XA 2.17 Inactive DFGout‑None in-out none-none TYR APEdihe_nniai APEdist_aaai CKK Type2 1050 - 1360 0 None Y1194F,Y1234F,Y1235D,L1272L Hepatocyte growth factor receptor
5T3QA 2.0 Inactive None‑None out-out none-out TYR APEdihe_nniai APEdist_aaao 75H Type1.5_Front 1050 - 1350 0 None None Hepatocyte growth factor receptor
2RFNA 2.5 Inactive None‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan AM7 Type1.5_Front 1057 - 1351 0 None None Hepatocyte growth factor receptor
2RFNB 2.5 Inactive None‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan AM7 Type1.5_Front 1056 - 1351 0 None None Hepatocyte growth factor receptor
3EFJB 2.6 Inactive None‑None out-none none-none TYR APEdihe_nnnai APEdist_aaan MT3 Type1.5_Front 1054 - 1351 0 None L1272L Hepatocyte growth factor receptor

TYR_MET (Hepatocyte growth factor receptor)

Total number of chains: 126
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 75 59.5% 3DKCA
DFGout BBAminus 31 24.6% 8OUUB
DFGout None 7 5.6% 3RHKA
None None 4 3.2% 3EFJB
DFGin ABAminus 3 2.4% 3Q6WA
DFGin BLAminus 2 1.6% AF-P08581-K1A
DFGin None 2 1.6% 3EFKA
DFGin BLBminus 1 0.8% 3Q6UA
DFGin BLBtrans 1 0.8% 5HLWA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
MET_HUMAN AF-P08581-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1068 - 1347 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN AF-P08581-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1068 - 1347 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 4IWDA 1.99 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai AME, 1JC Allosteric, Type1 1048 - 1348 0 PTR1234,PTR1235 None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3Q6WA 1.75 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai Q6W Type1 1050 - 1348 0 PTR1234,PTR1235 None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3R7OA 2.3 Inactive DFGin‑ABAminus in-in in-none TYR APEdihe_niiai APEdist_aaai M61 Type1 1048 - 1348 0 PTR1234,PTR1235 None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3Q6UA 1.6 Inactive DFGin‑BLBminus in-out none-none TYR APEdihe_nniai APEdist_aaai AME Allosteric 1048 - 1348 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3DKCA 1.52 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao ATP ATPlike 1051 - 1360 0 None Y1194F,Y1234F,Y1235D Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 2G15A 2.15 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 1046 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 1R1WA 1.8 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai No_ligand No_ligand 1050 - 1360 0 None Y1194F,Y1234F,Y1235D,L1272L Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 8AU3A 2.26 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nnoai APEdist_aaao 3E8 Type1 1052 - 1349 0 None Y1234E,Y1235E Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 8AU3B 2.26 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nnoai APEdist_aaao 3E8 Type1 1056 - 1349 0 None Y1234E,Y1235E Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 8AU5A 2.72 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 3E8 Type1 1067 - 1346 0 None F1200I Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 8AW1A 2.14 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_niiai APEdist_aaai 3E8 Type1 1066 - 1345 0 None Y1235D Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 8AW1B 2.14 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 3E8 Type1 1064 - 1345 0 None Y1235D Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 4KNBA 2.4 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 1RU Type1 1064 - 1344 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 4KNBB 2.4 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai 1RU Type1 1067 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 4KNBC 2.4 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 1RU Type1 1060 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 4KNBD 2.4 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nnnan APEdist_aaan 1RU Type1 1064 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 4R1VA 1.2 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 3E8 Type1 1055 - 1345 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 2WD1A 2.0 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai ZZY Type1 1055 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 4R1YA 2.0 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 3EH Type1 1062 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3F66A 1.4 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai IHX Type1 1052 - 1349 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3F66B 1.4 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai IHX Type1 1062 - 1349 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 7B3QA 1.75 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nnnai APEdist_aaan SV5 Type1 1055 - 1344 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 7B3TA 2.23 Inactive DFGin‑BLBplus out-none out-none TYR APEdihe_nniai APEdist_aaai SVK Type1 1062 - 1344 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 7B3VA 1.93 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai SWB Type1 1057 - 1344 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 7B3WA 2.02 Inactive DFGin‑BLBplus none-none out-in TYR APEdihe_iiiai APEdist_aaai SVH Type1 1067 - 1344 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 7B3ZA 1.8 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nnnai APEdist_aaan SV8 Type1 1055 - 1344 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 7B40A 1.76 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nnnai APEdist_aaan SWN Type1 1055 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 7B41A 1.97 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai SWK Type1 1055 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 7B42A 1.8 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai SW8 Type1 1055 - 1344 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 7B43A 1.87 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nnnai APEdist_aaan SW5 Type1 1055 - 1344 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 7B43B 1.87 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nnnai APEdist_aaan SW5 Type1 1055 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 7B44A 1.76 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nnnai APEdist_aaan SVT Type1 1055 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 2WGJA 2.0 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai VGH Type1 1052 - 1345 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 2WKMA 2.2 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai PFY Type1 1059 - 1345 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3ZBXA 2.2 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 6XE Type1 1059 - 1345 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3ZC5A 2.2 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai W9Z Type1 1052 - 1345 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3ZCLA 1.4 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 5TF Type1 1052 - 1345 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3ZXZA 1.8 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai KRW Type1 1052 - 1345 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3ZZEA 1.87 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 6XP Type1 1059 - 1345 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 4AOIA 1.9 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 4K0 Type1 1052 - 1344 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 4AP7A 1.8 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai F47 Type1 1052 - 1345 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 6SDEA 2.49 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai V0L Type1 1068 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 7Y4TA 2.16 Inactive DFGin‑BLBplus out-none out-in TYR APEdihe_iiiai APEdist_aaai I90 Type1 1063 - 1345 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 7Y4UA 2.26 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai I94 Type1 1061 - 1344 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 8GVJA 2.71 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai KGL Type1 1060 - 1344 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 8K78A 2.67 Inactive DFGin‑BLBplus out-none out-in TYR APEdihe_iiiai APEdist_aaai IYC Type1 1048 - 1345 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 9IVBA 2.35 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai A1L3A Type1 1040 - 1344 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 9IVBB 2.35 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai A1L3A Type1 1045 - 1344 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3I5NA 2.0 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_niiai APEdist_aaai B2D Type1 1052 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 4DEGA 2.0 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 0JJ Type1 1052 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 4DEHA 2.0 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 0JK Type1 1053 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 4DEIA 2.05 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 0JL Type1 1053 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 4XMOA 1.75 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 46G Type1 1051 - 1345 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 4XYFA 1.85 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 44X Type1 1052 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 5EYCA 1.8 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 5SZ Type1 1053 - 1345 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 5EYDA 1.85 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 5T1 Type1 1052 - 1348 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 2RFSA 2.2 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai AM8 Type1 1067 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3CCNA 1.9 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai LKG Type1 1055 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3CD8A 2.0 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai L5G Type1 1054 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 4GG5A 2.423 Inactive DFGin‑BLBplus out-none out-in TYR APEdihe_iiiai APEdist_aaai 0J3 Type1 1064 - 1344 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 4GG7A 2.27 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 0J8 Type1 1064 - 1344 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 5EOBA 1.75 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 5QQ Type1 1055 - 1345 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 5YA5A 1.89 Inactive DFGin‑BLBplus out-none out-in TYR APEdihe_iiiai APEdist_aaai 6TD Type1 1057 - 1345 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 5UABA 1.9 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 84M Type1 1029 - 1360 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 5UADA 2.25 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 84P Type1 1029 - 1360 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 6UBWA 2.0 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 84S Type1 1029 - 1360 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3DKGA 1.91 Inactive DFGin‑BLBplus out-none out-none TYR APEdihe_nniai APEdist_aaai SX8 Type1 1050 - 1356 0 None Y1194F,Y1230L,Y1234F,Y1235D Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 1R0PA 1.8 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao KSA Type1 1050 - 1360 0 None Y1194F,Y1234F,Y1235D,L1272L Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 5HNIX 1.71 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nnnan APEdist_aaan 63B Type1 1063 - 1356 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 5HNIY 1.71 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nnnan APEdist_aaan 63B Type1 1063 - 1356 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 5HO6A 1.97 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai 63K Type1 1063 - 1356 0 None Y1194F,Y1234F,Y1235D Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3QTIA 2.0 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao 3QT Type1 1052 - 1360 0 None Y1194F,Y1234F,Y1235D Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3QTIB 2.0 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao 3QT Type1 1058 - 1360 0 None Y1194F,Y1234F,Y1235D Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3DKFA 1.8 Inactive DFGin‑BLBplus out-none out-none TYR APEdihe_niiai APEdist_aaai SX8 Type1 1050 - 1360 0 None Y1194F,Y1234F,Y1235D Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3A4PA 2.54 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaai DFQ Type1 1063 - 1360 0 None Y1194F,Y1234F,Y1235D Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 5HOAA 2.14 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai 63K Type1 1065 - 1356 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 5HORA 2.2 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao 63K Type1 1064 - 1356 0 None Y1194F,Y1234F,Y1235D,M1250T Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3U6HA 2.0 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan 03X Type1.5_Front 1051 - 1351 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3U6IA 2.1 Inactive DFGin‑BLBplus out-out none-out TYR APEdihe_nniai APEdist_aaao 044 Type1.5_Front 1051 - 1351 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 5HLWA 1.97 Inactive DFGin‑BLBtrans out-out out-in TYR APEdihe_iiiai APEdist_aaai 62E Type1 1057 - 1355 0 None Y1230H Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3EFKA 2.2 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan MT4 Type1.5_Front 1054 - 1351 0 None L1272L Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3EFKB 2.2 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan MT4 Type1.5_Front 1054 - 1351 0 None L1272L Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3RHKB 1.94 Inactive DFGout‑BBAminus out-none out-in TYR APEdihe_iiiai APEdist_aaai M97 Type1 1046 - 1344 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 8ANSA 2.01 Inactive DFGout‑BBAminus out-none in-none TYR APEdihe_nniai APEdist_aaai MDI Type1.5_Front 1052 - 1346 0 None D1228V Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 8VI1A 3.11 Inactive DFGout‑BBAminus out-out out-out TYR APEdihe_iiiai APEdist_aaao A1AB1 Type1.5_Front 1053 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 8VI1B 3.11 Inactive DFGout‑BBAminus out-out out-in TYR APEdihe_iiiai APEdist_aaai A1AB1 Type1.5_Front 1050 - 1345 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 8AN8A 2.394 Inactive DFGout‑BBAminus out-out in-none TYR APEdihe_nnnai APEdist_aaan MDI Type1.5_Front 1073 - 1345 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 8AN8B 2.394 Inactive DFGout‑BBAminus out-out in-none TYR APEdihe_nniai APEdist_aaai MDI Type1.5_Front 1058 - 1345 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 6SDCA 1.67 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 88Z Type2 1052 - 1346 0 None D1228V Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 6SDDA 1.93 Inactive DFGout‑BBAminus out-out out-in TYR APEdihe_iiiai APEdist_aaai 353 Type2 1062 - 1344 0 None D1228V Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 9C1RA 1.59 Inactive DFGout‑BBAminus in-out none-none TYR APEdihe_nnnai APEdist_aaan A1ATS Type2 1048 - 1348 0 None D1228N Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3LQ8A 2.02 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 88Z Type2 1053 - 1345 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 6SD9A 2.35 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 88Z Type2 1062 - 1345 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 4EEVA 1.8 Inactive DFGout‑BBAminus in-out none-none TYR APEdihe_niiai APEdist_aaai L1X Type2 1045 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 4MXCA 1.632 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai DWF Type2 1052 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 5HTIA 1.66 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 66L Type2 1052 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 7V3SA 1.9 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 5I9 Type2 1053 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3VW8A 2.1 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai DF6 Type2 1024 - 1352 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3CE3A 2.4 Inactive DFGout‑BBAminus out-out none-out TYR APEdihe_oiiai APEdist_aaai 1FN Type2 1054 - 1360 0 None Y1194F,Y1234F,Y1235D,L1272L Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3CTHA 2.3 Inactive DFGout‑BBAminus out-out none-out TYR APEdihe_oiiai APEdist_aaai 319 Type2 1052 - 1360 0 None Y1194F,Y1234F,Y1235D Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3F82A 2.5 Inactive DFGout‑BBAminus out-out none-none TYR APEdihe_niiai APEdist_aaai 353 Type2 1055 - 1360 0 None Y1194F,Y1234F,Y1235D Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3L8VA 2.4 Inactive DFGout‑BBAminus in-out none-out TYR APEdihe_oiiai APEdist_aaai L8V Type2 1054 - 1360 0 None Y1194F,Y1234F,Y1235D Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 8OUUA 1.77 Inactive DFGout‑BBAminus out-out out-in TYR APEdihe_iiiai APEdist_aaai W49 Type3 1059 - 1346 0 None D1228V Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 8OUUB 1.77 Inactive DFGout‑BBAminus out-out out-out TYR APEdihe_iiiai APEdist_aaao W49 Type3 1057 - 1346 0 None D1228V Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 8OUVA 1.783 Inactive DFGout‑BBAminus out-out out-out TYR APEdihe_iiiai APEdist_aaao W3R Type3 1053 - 1346 0 None D1228V Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 8OUVB 1.783 Inactive DFGout‑BBAminus out-out out-out TYR APEdihe_iiiai APEdist_aaao W3R Type3 1057 - 1346 0 None D1228V Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 8OV7A 1.95 Inactive DFGout‑BBAminus out-out out-out TYR APEdihe_iioai APEdist_aaao W3W Type3 1051 - 1346 0 None D1228V Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 8OVZA 2.206 Inactive DFGout‑BBAminus out-out out-out TYR APEdihe_iiiai APEdist_aaao W3N Type3 1061 - 1346 0 None D1228V Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 8OVZB 2.206 Inactive DFGout‑BBAminus out-out out-out TYR APEdihe_iiiai APEdist_aaao W3N Type3 1057 - 1346 0 None D1228V Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 8OWGA 2.631 Inactive DFGout‑BBAminus out-none out-none TYR APEdihe_nnnai APEdist_aaan W40 Type3 1060 - 1344 0 None D1228V Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 8OWGB 2.631 Inactive DFGout‑BBAminus out-none out-in TYR APEdihe_iiiai APEdist_aaai W40 Type3 1060 - 1343 0 None D1228V Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 8OWGC 2.631 Inactive DFGout‑BBAminus out-none none-out TYR APEdihe_nniai APEdist_aaao W40 Type3 1060 - 1343 0 None D1228V Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 8OW3A 2.27 Inactive DFGout‑BBAminus out-none none-none TYR APEdihe_nniai APEdist_aaai W40 Type3 1058 - 1345 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3RHKA 1.94 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai M97 Type1 1049 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3EFJA 2.6 Inactive DFGout‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan MT3 Type1.5_Front 1054 - 1351 0 None L1272L Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 5DG5A 2.6 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 5B4 Type2 1050 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 5DG5B 2.6 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 5B4 Type2 1050 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 7V3RA 1.7 Inactive DFGout‑None in-out out-none TYR APEdihe_nniai APEdist_aaai 5IE Type2 1053 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3CTJA 2.5 Inactive DFGout‑None in-in none-none TYR APEdihe_nniai APEdist_aaai 320 Type2 1051 - 1360 0 None Y1194F,Y1234F,Y1235D Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3C1XA 2.17 Inactive DFGout‑None in-out none-none TYR APEdihe_nniai APEdist_aaai CKK Type2 1050 - 1360 0 None Y1194F,Y1234F,Y1235D,L1272L Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 5T3QA 2.0 Inactive None‑None out-out none-out TYR APEdihe_nniai APEdist_aaao 75H Type1.5_Front 1050 - 1350 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 2RFNA 2.5 Inactive None‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan AM7 Type1.5_Front 1057 - 1351 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 2RFNB 2.5 Inactive None‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan AM7 Type1.5_Front 1056 - 1351 0 None None Hepatocyte growth factor receptor Homo sapiens
MET_HUMAN 3EFJB 2.6 Inactive None‑None out-none none-none TYR APEdihe_nnnai APEdist_aaan MT3 Type1.5_Front 1054 - 1351 0 None L1272L Hepatocyte growth factor receptor Homo sapiens

TYR_MET (Hepatocyte growth factor receptor)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism