Ligand: 537

Total number of chains: 4
Active chains: 1
Total number of genes: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 50.0% 1UKIA
DFGin BLAminus 1 25.0% 5LVLA
DFGin None 1 25.0% 1PMVA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AGC PDPK1 PDPK1_HUMAN 5LVLA 1.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 537 Type1 74 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
CMGC MAPK10 MK10_HUMAN 1PMVA 2.5 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiii APEdist_oioo 537 Type1 45 - 400 0 None None Mitogen-activated protein kinase 10
CMGC MAPK8 MK08_HUMAN 1UKIA 2.7 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aanio APEdist_nnnn 537 Type1 9 - 363 0 None None Mitogen-activated protein kinase 8
OTHER TTK TTK_HUMAN 2ZMDA 2.88 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaoni APEdist_oooo 537 Type1 516 - 795 0 None T686A Dual specificity protein kinase TTK

Ligand: 537

Total number of chains: 4
Active chains: 1
Total number of genes: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 2 50.0% 1UKIA
DFGin BLAminus 1 25.0% 5LVLA
DFGin None 1 25.0% 1PMVA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
AGC PDPK1 PDPK1_HUMAN 5LVLA 1.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 537 Type1 74 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
CMGC MAPK10 MK10_HUMAN 1PMVA 2.5 Inactive DFGin‑None out-out none-out nonTYR APEdihe_aaiii APEdist_oioo 537 Type1 45 - 400 0 None None Mitogen-activated protein kinase 10 Homo sapiens
CMGC MAPK8 MK08_HUMAN 1UKIA 2.7 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aanio APEdist_nnnn 537 Type1 9 - 363 0 None None Mitogen-activated protein kinase 8 Homo sapiens
OTHER TTK TTK_HUMAN 2ZMDA 2.88 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaoni APEdist_oooo 537 Type1 516 - 795 0 None T686A Dual specificity protein kinase TTK Homo sapiens

Ligand: 537

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism