IKBKB (Inhibitor of nuclear factor kappa-B kinase subunit beta)

Group: OTHER

Uniprot: IKKB_HUMAN

Domain boundary: 15 - 308

Total number of chains: 14

Spatial	Dihedral	Chains	Representative
DFGin	BLAminus	9	AF-O14920-K1A
DFGin	BLBminus	1	8OMVB
DFGin	None	2	4E3CA
DFGinter	None	1	8OMVE
None	None	1	8OMVA

Database table as tsv

PDB	Resolution	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type	Residues in structure	Mutation	Phosphorylation	Unresolved residues in A-loop
AF-O14920-K1A	-1.0	Active	DFGin	BLAminus	in-in	in-in	No_ligand	No_ligand	7 - 316	None	None	0
4E3CB	3.98	Inactive	DFGin	BLAminus	in-in	in-out	No_ligand	No_ligand	16 - 665	S177E,S181E	None	0
4E3CC	3.98	Inactive	DFGin	BLAminus	in-in	in-out	No_ligand	No_ligand	16 - 665	S177E,S181E	None	0
4E3CD	3.98	Inactive	DFGin	BLAminus	in-in	in-out	No_ligand	No_ligand	16 - 665	S177E,S181E	None	0
4E3CF	3.98	Inactive	DFGin	BLAminus	in-in	in-out	No_ligand	No_ligand	16 - 665	S177E,S181E	None	0
8OMVC	4.16	Inactive	DFGin	BLAminus	in-out	out-out	No_ligand	No_ligand	12 - 664	S177E,S181E	None	7
8OMVD	4.16	Inactive	DFGin	BLAminus	in-out	out-out	No_ligand	No_ligand	6 - 665	S177E,S181E	None	8
4KIKA	2.83	None	DFGin	BLAminus	in-in	none-out	KSA	Type1	9 - 663	None	X257	10
4KIKB	2.83	Active	DFGin	BLAminus	in-in	in-in	KSA	Type1	2 - 663	None	X177,X181	3
8OMVB	4.16	Inactive	DFGin	BLBminus	in-out	out-out	No_ligand	No_ligand	8 - 664	S177E,S181E	None	9
4E3CA	3.98	Inactive	DFGin	None	in-in	in-out	No_ligand	No_ligand	16 - 665	S177E,S181E	None	0
4E3CE	3.98	Inactive	DFGin	None	in-in	in-out	No_ligand	No_ligand	16 - 665	S177E,S181E	None	0
8OMVE	4.16	Inactive	DFGinter	None	in-out	out-out	No_ligand	No_ligand	9 - 643	S177E,S181E	None	3
8OMVA	4.16	Inactive	None	None	in-in	out-out	No_ligand	No_ligand	8 - 666	S177E,S181E	None	13

IKBKB (Inhibitor of nuclear factor kappa-B kinase subunit beta)

Group: OTHER

Total number of chains: 14

Spatial	Dihedral	Chains	Representative
DFGin	BLAminus	9	AF-O14920-K1A
DFGin	BLBminus	1	8OMVB
DFGin	None	2	4E3CA
DFGinter	None	1	8OMVE
None	None	1	8OMVA

Database table as tsv

Organism	UniprotID	PDB	Resolution	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type	Residues in structure	Mutation	Phosphorylation	Unresolved residues in A-loop
Homo sapiens	IKKB_HUMAN	AF-O14920-K1A	-1.0	Active	DFGin	BLAminus	in-in	in-in	No_ligand	No_ligand	7 - 316	None	None	0
Homo sapiens	IKKB_HUMAN	4E3CB	3.98	Inactive	DFGin	BLAminus	in-in	in-out	No_ligand	No_ligand	16 - 665	S177E,S181E	None	0
Homo sapiens	IKKB_HUMAN	4E3CC	3.98	Inactive	DFGin	BLAminus	in-in	in-out	No_ligand	No_ligand	16 - 665	S177E,S181E	None	0
Homo sapiens	IKKB_HUMAN	4E3CD	3.98	Inactive	DFGin	BLAminus	in-in	in-out	No_ligand	No_ligand	16 - 665	S177E,S181E	None	0
Homo sapiens	IKKB_HUMAN	4E3CF	3.98	Inactive	DFGin	BLAminus	in-in	in-out	No_ligand	No_ligand	16 - 665	S177E,S181E	None	0
Homo sapiens	IKKB_HUMAN	8OMVC	4.16	Inactive	DFGin	BLAminus	in-out	out-out	No_ligand	No_ligand	12 - 664	S177E,S181E	None	7
Homo sapiens	IKKB_HUMAN	8OMVD	4.16	Inactive	DFGin	BLAminus	in-out	out-out	No_ligand	No_ligand	6 - 665	S177E,S181E	None	8
Homo sapiens	IKKB_HUMAN	4KIKA	2.83	None	DFGin	BLAminus	in-in	none-out	KSA	Type1	9 - 663	None	X257	10
Homo sapiens	IKKB_HUMAN	4KIKB	2.83	Active	DFGin	BLAminus	in-in	in-in	KSA	Type1	2 - 663	None	X177,X181	3
Homo sapiens	IKKB_HUMAN	8OMVB	4.16	Inactive	DFGin	BLBminus	in-out	out-out	No_ligand	No_ligand	8 - 664	S177E,S181E	None	9
Homo sapiens	IKKB_HUMAN	4E3CA	3.98	Inactive	DFGin	None	in-in	in-out	No_ligand	No_ligand	16 - 665	S177E,S181E	None	0
Homo sapiens	IKKB_HUMAN	4E3CE	3.98	Inactive	DFGin	None	in-in	in-out	No_ligand	No_ligand	16 - 665	S177E,S181E	None	0
Homo sapiens	IKKB_HUMAN	8OMVE	4.16	Inactive	DFGinter	None	in-out	out-out	No_ligand	No_ligand	9 - 643	S177E,S181E	None	3
Homo sapiens	IKKB_HUMAN	8OMVA	4.16	Inactive	None	None	in-in	out-out	No_ligand	No_ligand	8 - 666	S177E,S181E	None	13

IKBKB (Inhibitor of nuclear factor kappa-B kinase subunit beta)

No non-human structures known.