Ligand: ANP

Total number of chains: 394
Active chains: 62
Total number of genes: 79
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 160 40.6% 8QCGA
DFGin BLBplus 140 35.5% 2SRCA
DFGin BLBtrans 31 7.9% 5X2AB
DFGin None 22 5.6% 6BXIA
DFGin ABAminus 16 4.1% 8R5EA
DFGinter None 10 2.5% 7OPOG
DFGin BLAplus 5 1.3% 2OZOA
DFGin BLBminus 5 1.3% 4LGDA
None None 3 0.8% 7F2XA
DFGout None 2 0.5% 6VPHA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AGC AKT1 AKT1_HUMAN 4EKKA 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 144 - 477 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 4EKKB 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 144 - 477 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 1O6KA 1.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 146 - 479 0 TPO309 S474D RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 1O6LA 1.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 146 - 477 0 TPO309 None RAC-beta serine/threonine-protein kinase
AGC GRK5 GRK5_HUMAN 4TNDA 1.802 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 15 - 543 0 None None G protein-coupled receptor kinase 5
AGC GRK6 GRK6_HUMAN 2ACXA 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 14 - 532 0 None C561S,C562S,C565S G protein-coupled receptor kinase 6
AGC GRK6 GRK6_HUMAN 2ACXB 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 14 - 535 0 None C561S,C562S,C565S G protein-coupled receptor kinase 6
AGC PRKCB KPCB_HUMAN 8SE1A 3.32 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 19 - 668 0 TPO500,TPO642,SEP661 None Protein kinase C beta type
AGC PRKCB KPCB_HUMAN 8SE1B 3.32 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 19 - 668 0 TPO500,TPO642,SEP661 None Protein kinase C beta type
AGC PRKCB KPCB_HUMAN 8SE2B 2.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 30 - 671 0 TPO500,TPO642,SEP661 None Protein kinase C beta type
AGC PRKCI KPCI_HUMAN 8R3YI 3.68 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 248 - 585 0 TPO412,TPO564 None Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 5LI1A 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 248 - 589 0 TPO412,SEP484,TPO564 None Protein kinase C iota type
AGC PRKG1 KGP1_HUMAN 6BG2A 1.83 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 336 - 671 0 TPO517 None cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 6BG2B 1.83 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 346 - 671 0 TPO517 None cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 6BG2C 1.83 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 337 - 671 0 TPO517 None cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 6BG2D 1.83 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 344 - 671 0 TPO517 None cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7LV3A 2.41 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 57 - 671 0 TPO517 None cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7LV3B 2.41 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 58 - 671 0 TPO517 None cGMP-dependent protein kinase 1
AGC ROCK1 ROCK1_HUMAN 2V55A 3.705 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 6 - 404 0 None None Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 2V55C 3.705 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 6 - 404 0 None None Rho-associated protein kinase 1
AGC RPS6KA1-1 KS6A1_HUMAN 8XOVA 2.55 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaiii APEdist_nioo ANP ATPlike 56 - 340 0 None None Ribosomal protein S6 kinase alpha-1
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOA 2.75 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aanoi APEdist_oonn ANP ATPlike 45 - 348 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOE 2.75 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aanoi APEdist_oonn ANP ATPlike 46 - 348 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOI 2.75 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aanoi APEdist_onnn ANP ATPlike 46 - 348 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOK 2.75 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aanoi APEdist_oonn ANP ATPlike 46 - 348 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOC 2.75 Inactive DFGinter‑None none-none out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 46 - 347 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOG 2.75 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanni APEdist_oonn ANP ATPlike 46 - 348 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA6-1 KS6A6_HUMAN 6G77A 2.499 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aaiii APEdist_iooi ANP, ANP Allosteric, ATPlike 51 - 349 0 None None Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G77B 2.499 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aaiii APEdist_iooi ANP, ANP Allosteric, ATPlike 51 - 349 0 None None Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G76B 3.0 Inactive DFGinter‑None none-none out-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 51 - 349 0 SEP232 None Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G78A 2.5 Inactive DFGinter‑None none-none out-out nonTYR APEdihe_aaoii APEdist_nnno ANP ATPlike 51 - 349 0 None S232E Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G78B 2.5 Inactive DFGinter‑None none-none out-out nonTYR APEdihe_aaiii APEdist_nnno ANP ATPlike 51 - 349 0 None S232E Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G76A 3.0 Inactive DFGinter‑None none-none out-out nonTYR APEdihe_aaiii APEdist_iooi ANP, ANP ATPlike, Allosteric 51 - 349 0 SEP232 None Ribosomal protein S6 kinase alpha-6
AGC SGK1 SGK1_HUMAN 2R5TA 1.9 Inactive DFGinter‑None none-none out-out nonTYR APEdihe_aaiio APEdist_oooo ANP ATPlike 82 - 378 0 None S74A,S78A,S397A,S401A Serine/threonine-protein kinase Sgk1
AGC STK38 STK38_HUMAN 6BXIA 2.2 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 82 - 414 0 None None Serine/threonine-protein kinase 38
AGC STK38 STK38_HUMAN 6BXIB 2.2 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 83 - 414 0 None None Serine/threonine-protein kinase 38
CAMK AURKA AURKA_HUMAN 2DWBA 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ANP ATPlike 126 - 389 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPGA 2.64 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 7 - 389 0 TPO287,TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPIA 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioo ANP ATPlike 104 - 389 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPLA 1.86 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_oooo ANP, R7D ATPlike, Allosteric 7 - 389 0 TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPLB 1.86 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_oooo ANP, R7D ATPlike, Allosteric 7 - 389 0 TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 2C6DA 2.2 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno ANP ATPlike 126 - 390 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPJA 2.1 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaooi APEdist_iioo ANP ATPlike 104 - 389 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPHA 2.14 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo ANP ATPlike 7 - 389 0 TPO287,TPO288 None Aurora kinase A
CAMK CASK CSKP_HUMAN 3MFRA 2.0 Pseudo DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 5 - 306 0 None P22A,H145E,C146N,G162D Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3MFSA 2.1 Pseudo DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 4 - 306 0 None P22A,H145E,C146N,G162D Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3MFUA 2.3 Pseudo DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 5 - 306 0 None P22A,H145E,C146N,G162D Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 9M6GA 1.7 Pseudo DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 5 - 312 0 None None Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 9M5YA 1.8 Pseudo DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 3 - 312 0 None None Peripheral plasma membrane protein CASK
CAMK CHEK1 CHK1_HUMAN 5OOPA 1.7 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 5 - 271 0 None N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S Serine/threonine-protein kinase Chk1
CAMK DAPK1 DAPK1_HUMAN 1IG1A 1.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ANP ATPlike 2 - 294 0 None None Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 1JKKA 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ANP ATPlike 2 - 293 0 None None Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 1JKLA 1.62 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ANP ATPlike 2 - 294 0 None None Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3EHAA 1.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ANP ATPlike 2 - 277 0 None None Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3F5UA 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ANP ATPlike 2 - 277 0 None None Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3DFCB 1.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ANP ATPlike 2 - 277 0 None Q23K Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3GU4A 1.35 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ANP ATPlike 2 - 277 0 None Q23V Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3GU5A 1.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ANP ATPlike 2 - 277 0 None Q23V Death-associated protein kinase 1
CAMK MELK MELK_HUMAN 4BL1A 2.6 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn ANP ATPlike 2 - 333 0 None None Maternal embryonic leucine zipper kinase
CAMK PIM1 PIM1_HUMAN 1YXTA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 33 - 306 0 None None Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 1XR1A 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 32 - 308 0 None None Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3A99A 1.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 33 - 305 0 None None Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 2BZKB 2.45 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 33 - 305 0 None R250G Serine/threonine-protein kinase pim-1
CAMK PLK1 PLK1_HUMAN 8X72A 2.2 Inactive DFGin‑BLAminus out-in in-out nonTYR APEdihe_aaiio APEdist_ioio ANP ATPlike 37 - 330 0 None None Serine/threonine-protein kinase PLK1
CAMK PLK1 PLK1_HUMAN 2OU7A 2.4 Inactive DFGin‑BLAminus out-in in-out nonTYR APEdihe_aaiio APEdist_ioio ANP ATPlike 37 - 328 0 None T210V Serine/threonine-protein kinase PLK1
CAMK PLK4 PLK4_HUMAN 3COKA 2.25 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 2 - 266 0 None None Serine/threonine-protein kinase PLK4
CAMK PLK4 PLK4_HUMAN 3COKB 2.25 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 2 - 266 0 None None Serine/threonine-protein kinase PLK4
CAMK RPS6KA5-2 KS6A5_HUMAN 3KN5A 2.4 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 415 - 729 0 None None Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA5-2 KS6A5_HUMAN 3KN5B 2.4 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 415 - 729 0 None None Ribosomal protein S6 kinase alpha-5
CAMK STK11 STK11_HUMAN 2WTKC 2.65 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 47 - 342 0 None D194A Serine/threonine-protein kinase STK11
CAMK STK11 STK11_HUMAN 2WTKF 2.65 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 45 - 340 0 None D194A Serine/threonine-protein kinase STK11
CK1 VRK1 VRK1_HUMAN 6AC9A 2.07 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ANP ATPlike 21 - 342 0 None K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 6AC9B 2.07 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ANP ATPlike 21 - 341 0 None K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 6AC9C 2.07 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii ANP ATPlike 24 - 341 0 None K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 6AC9D 2.07 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii ANP ATPlike 23 - 341 0 None K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A Serine/threonine-protein kinase VRK1
CMGC CDK1 CDK1_HUMAN 9SKQA 3.4 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaooo APEdist_iiii ANP ATPlike 3 - 288 0 TPO161 None Cyclin-dependent kinase 1
CMGC CDK12 CDK12_HUMAN 4CXAA 3.15 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 718 - 1050 0 TPO893 None Cyclin-dependent kinase 12
CMGC CDK2 CDK2_HUMAN 9QCVK 2.5 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iooi ANP ATPlike 1 - 292 0 None None Cyclin-dependent kinase 2
CMGC CDK7 CDK7_HUMAN 8R99A 1.81 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iooi ANP ATPlike 10 - 311 0 None W132R,S164D,T170E Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 9QCVJ 2.5 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iooi ANP ATPlike 10 - 346 0 None None Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 9SKQJ 3.4 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iooi ANP ATPlike 9 - 346 0 None None Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BA 2.21 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo ANP ATPlike 1 - 311 0 None S164D,T170E Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BB 2.21 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo ANP ATPlike 3 - 310 0 None S164D,T170E Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BC 2.21 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoii APEdist_nnoo ANP ATPlike 8 - 311 0 None S164D,T170E Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BD 2.21 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooi APEdist_nnoo ANP ATPlike 9 - 311 0 None S164D,T170E Cyclin-dependent kinase 7
CMGC CDK9 CDK9_HUMAN 3MIAA 3.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 8 - 340 0 TPO186 None Cyclin-dependent kinase 9
CMGC CSNK2A1 CSK21_HUMAN 3JUHA 1.66 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 2 - 335 0 None V66A,M163L Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 3JUHB 1.66 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 2 - 335 0 None V66A,M163L Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 3NSZA 1.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 2 - 328 0 None None Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 1PJKA 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 2 - 332 0 None None Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 2PVRA 1.605 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 2 - 329 0 None None Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 3WOWA 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 2 - 335 0 None None Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 1JWHA 3.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 2 - 337 0 None None Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 3U87A 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 2 - 331 0 None None Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 3U87B 2.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 2 - 331 0 None None Casein kinase II subunit alpha
CMGC CSNK2A2 CSK22_HUMAN 8QCGA 1.04 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 7 - 330 0 None C336S Casein kinase II subunit alpha'
CMGC CSNK2A2 CSK22_HUMAN 8QCGB 1.04 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 7 - 333 0 None C336S Casein kinase II subunit alpha'
CMGC DYRK1A DYR1A_HUMAN 7A4OA 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 136 - 481 0 PTR321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7A4OB 1.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii ANP ATPlike 134 - 481 0 PTR321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC GSK3B GSK3B_HUMAN 1J1BA 1.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 35 - 388 0 None None Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 1J1BB 1.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 23 - 386 0 None None Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 8XN6A 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 35 - 384 0 None None Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 8XN6B 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 26 - 386 0 None None Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 1PYXA 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 35 - 386 0 None None Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 1PYXB 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 35 - 383 0 None None Glycogen synthase kinase-3 beta
CMGC MAPK1 MK01_HUMAN 4H3QA 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooo APEdist_iioo ANP ATPlike 9 - 360 0 None R77A,C161S,I255G,E314A Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6OPGA 2.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 10 - 358 0 TPO185,PTR187 None Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 2Y9QA 1.55 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ANP ATPlike 9 - 358 0 None None Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4FMQA 2.098 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ANP ATPlike 9 - 358 0 None None Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4NIFB 2.15 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ANP ATPlike 9 - 360 0 None None Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4NIFE 2.15 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ANP ATPlike 10 - 360 0 None None Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8PSRA 1.85 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ANP ATPlike 1 - 358 0 None None Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 3TEIA 2.404 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ANP ATPlike 10 - 358 0 None R77A,E314A Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4H3PA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ANP ATPlike 11 - 359 0 None R77A,E314A Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4H3PD 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn ANP ATPlike 11 - 359 0 None R77A,E314A Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8PT0A 1.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oioo ANP, EAI ATPlike, Allosteric 11 - 358 0 None None Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8PT1A 1.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ANP, E2A ATPlike, Allosteric 11 - 359 0 None None Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8PT5A 1.95 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ANP, D5R ATPlike, Allosteric 10 - 358 0 None None Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8R5FA 1.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno ANP, Y3H ATPlike, Allosteric 11 - 359 0 None None Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8PT3A 1.8 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_oiio D7O, ANP Allosteric, ATPlike 10 - 359 0 None None Mitogen-activated protein kinase 1
CMGC MAPK10 MK10_HUMAN 8WGFA 1.85 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaiii APEdist_oooo ANP ATPlike 44 - 400 0 None None Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 1JNKA 2.3 Inactive DFGin‑ABAminus in-out none-out nonTYR APEdihe_aaiii APEdist_oooo ANP ATPlike 45 - 400 0 None None Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 4Z9LA 2.1 Inactive DFGin‑ABAminus out-out none-out nonTYR APEdihe_aaiii APEdist_nnno ANP, 880 Allosteric, Type1 45 - 400 0 None None Mitogen-activated protein kinase 10
CMGC MAPK12 MK12_HUMAN 1CM8A 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 8 - 353 0 TPO183,PTR185 None Mitogen-activated protein kinase 12
CMGC MAPK12 MK12_HUMAN 1CM8B 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 8 - 353 0 TPO183,PTR185 None Mitogen-activated protein kinase 12
CMGC MAPK7 MK07_HUMAN 4IC7A 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iooi ANP ATPlike 46 - 400 0 None None Mitogen-activated protein kinase 7
CMGC MAPK7 MK07_HUMAN 4IC7D 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iooi ANP ATPlike 47 - 399 0 None None Mitogen-activated protein kinase 7
CMGC MAPK8 MK08_HUMAN 6ZR5A 2.699 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn ANP ATPlike 3 - 362 0 None None Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 6ZR5B 2.699 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaiii APEdist_oioo ANP ATPlike 4 - 362 0 None None Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 2XRWA 1.33 Inactive DFGin‑ABAminus in-out none-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 2 - 364 0 None None Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 2XS0A 2.6 Inactive DFGin‑ABAminus in-out none-out nonTYR APEdihe_aanoo APEdist_nnnn ANP ATPlike 6 - 365 0 None T183V,Y185F Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 4UX9A 2.34 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 8 - 363 0 None None Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 4UX9C 2.34 Inactive DFGin‑ABAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii ANP ATPlike 8 - 363 0 None None Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 4UX9D 2.34 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioo APEdist_oioo ANP ATPlike 9 - 364 0 None None Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 8R5EA 1.7 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaiii APEdist_oooo ANP, Y6K ATPlike, Allosteric 5 - 363 0 None None Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 4QTDA 1.5 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaiii APEdist_oooo 38Z, ANP Type1, Allosteric 6 - 363 0 None None Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 9FT9A 2.35 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_oioo ANP ATPlike 7 - 363 0 None None Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 4UX9B 2.34 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 8 - 362 0 None None Mitogen-activated protein kinase 8
CMGC PRP4K PRP4K_HUMAN 4IIRA 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oioi ANP ATPlike 668 - 1005 0 PTR849 None Serine/threonine-protein kinase PRP4 homolog
CMGC PRP4K PRP4K_HUMAN 4IIRB 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oioi ANP ATPlike 670 - 1005 0 PTR849 None Serine/threonine-protein kinase PRP4 homolog
CMGC SRPK1 SRPK1_HUMAN 3BEGA 2.9 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 69 - 655 0 None None SRSF protein kinase 1
OTHER EIF2AK2 E2AK2_HUMAN 2A19B 2.5 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ANP ATPlike 258 - 541 0 TPO446 H412N,C551A Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 2A19C 2.5 Inactive DFGin‑ABAminus in-in none-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 258 - 541 0 TPO446 H412N,C551A Interferon-induced, double-stranded RNA-activated protein kinase
OTHER TP53RK PRPK_HUMAN 6WQXC 2.53 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP ATPlike 17 - 247 0 None None EKC/KEOPS complex subunit TP53RK
OTHER TP53RK PRPK_HUMAN 6WQXD 2.53 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP ATPlike 18 - 247 0 None None EKC/KEOPS complex subunit TP53RK
OTHER WNK1 WNK1_HUMAN 5WDYA 2.458 None DFGin‑BLAminus out-na in-none nonTYR APEdihe_aannn APEdist_nnnn ANP, A6S ATPlike, Type3 208 - 481 0 None S378D,E396A,E397A,K398A Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 5WDYB 2.458 Inactive DFGin‑BLAminus out-na in-out nonTYR APEdihe_aanoo APEdist_nnnn ANP, A6S ATPlike, Type3 206 - 480 0 None S378D,E396A,E397A,K398A Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 5WE8A 2.006 Inactive DFGin‑BLAminus out-na in-out nonTYR APEdihe_aaioo APEdist_oooo ANP, A7Y ATPlike, Type3 209 - 483 0 None S378D,E396A,E397A,K398A Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 5WE8B 2.006 Inactive DFGin‑BLAminus out-na in-out nonTYR APEdihe_aaiio APEdist_oooo ANP, A7Y ATPlike, Type3 207 - 480 0 None S378D,E396A,E397A,K398A Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 5TF9A 2.5 Inactive DFGin‑BLAminus out-na in-out nonTYR APEdihe_aaioo APEdist_nnno 7AV, ANP Type3, ATPlike 210 - 483 0 None None Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 5TF9B 2.5 Inactive DFGin‑BLAminus out-na in-out nonTYR APEdihe_aaiio APEdist_nnno 7AV, ANP Type3, ATPlike 206 - 480 0 None None Serine/threonine-protein kinase WNK1
OTHER WNK3 WNK3_HUMAN 5O26A 2.379 Active DFGin‑BLAminus out-na in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 135 - 414 0 SEP304,SEP308 None Serine/threonine-protein kinase WNK3
OTHER WNK3 WNK3_HUMAN 5O26B 2.379 Active DFGin‑BLAminus out-na in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 136 - 413 0 SEP304,SEP308 None Serine/threonine-protein kinase WNK3
STE MAP2K1 MP2K1_HUMAN 5YT3C 2.9 Inactive DFGin‑BLBplus out-none none-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 40 - 382 0 None S218D,S222D,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 6V2WB 3.12 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP ATPlike 40 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3SLSA 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nooo ANP, 77D ATPlike, Type3 45 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3SLSB 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nooo ANP, 77D ATPlike, Type3 45 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B3MA 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnno ANP, SU5 ATPlike, Type3 37 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B3MB 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_nnno ANP, SU5 ATPlike, Type3 37 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B7RA 1.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnno ANP, T1K ATPlike, Type3 37 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B7RB 1.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoo APEdist_nnnn ANP, T1K ATPlike, Type3 39 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B94A 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_nnno ANP, T3W ATPlike, Type3 37 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B94B 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoo APEdist_nnnn ANP, T3W ATPlike, Type3 41 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B9LA 1.7 Inactive DFGin‑BLBplus out-out out-none nonTYR APEdihe_aannn APEdist_nnnn ANP, T4N ATPlike, Type3 37 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B9LB 1.7 Inactive DFGin‑BLBplus out-out out-none nonTYR APEdihe_aannn APEdist_nnnn ANP, T4N ATPlike, Type3 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3ORNA 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 3OR ATPlike, Type3 62 - 380 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3WIGA 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, CHU ATPlike, Type3 62 - 380 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4U80A 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_nnoo ANP, 3EX ATPlike, Type3 62 - 379 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4LMNA 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, EUI ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7UMBC 3.231 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, U9F ATPlike, Type3 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 6PP9B 2.59 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, LCJ ATPlike, Type3 38 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0VB 3.16 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, EUI ATPlike, Type3 42 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0WB 3.09 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, QOA ATPlike, Type3 42 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0XB 2.47 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 4BM ATPlike, Type3 40 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0YB 3.45 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, QOM ATPlike, Type3 43 - 382 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0ZB 3.12 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, CHU ATPlike, Type3 42 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXHA 2.81 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 39 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXHB 2.81 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 38 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXMA 2.42 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 38 - 382 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXXA 2.07 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 41 - 382 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXXC 2.07 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 37 - 378 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AYAB 2.59 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 42 - 382 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AYAD 2.59 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnno A1AHE, ANP Type1, ATPlike 39 - 382 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AY7B 2.41 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 33 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0UH 2.91 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo CHU, ANP Type1, ATPlike 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0VB 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU, ANP Type1, ATPlike 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0VH 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo CHU, ANP Type1, ATPlike 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4U7ZA 2.805 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_onoo 3EW, ANP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4U81A 2.701 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo 3EY, ANP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9ECUB 3.46 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo A1BIS, ANP Type3, ATPlike 43 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXYB 3.6 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type3, ATPlike 40 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0VD 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU, ANP Type3, ATPlike 31 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0VF 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU, ANP Type3, ATPlike 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0TB 3.19 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo 3EW, ANP Type3, ATPlike 42 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0UB 3.09 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo QO7, ANP Type3, ATPlike 43 - 385 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 5YT3B 2.9 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoio APEdist_oooo ANP ATPlike 40 - 382 0 None S218D,S222D,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 5YT3D 2.9 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP ATPlike 39 - 382 0 None S218D,S222D,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 5YT3A 2.9 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanno APEdist_nnnn ANP ATPlike 39 - 382 0 None S218D,S222D,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7F2XA 2.007 Inactive None‑None out-out out-out nonTYR APEdihe_aaiio APEdist_oooo ANP ATPlike 45 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K4 MP2K4_HUMAN 3ALNA 2.3 Inactive DFGin‑BLBplus out-na out-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 83 - 389 0 None None Dual specificity mitogen-activated protein kinase kinase 4
STE MAP2K4 MP2K4_HUMAN 3ALNB 2.3 Inactive DFGin‑BLBplus out-na out-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 84 - 390 0 None None Dual specificity mitogen-activated protein kinase kinase 4
STE MAP2K4 MP2K4_HUMAN 3ALOA 2.6 Inactive DFGin‑BLBplus out-na out-out nonTYR APEdihe_aaoao APEdist_oooo ANP ATPlike 95 - 389 0 None None Dual specificity mitogen-activated protein kinase kinase 4
STE MAP2K4 MP2K4_HUMAN 3ALNC 2.3 Inactive None‑None none-na none-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 100 - 390 0 None None Dual specificity mitogen-activated protein kinase kinase 4
STE MAP4K1 M4K1_HUMAN 6CQDA 2.12 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 2 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6CQDB 2.12 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 4 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K4 M4K4_HUMAN 4U40A 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 17 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE OXSR1 OXSR1_HUMAN 3DAKA 2.25 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo ANP ATPlike 6 - 295 0 None None Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 3DAKB 2.25 Inactive DFGin‑BLBtrans out-out out-none nonTYR APEdihe_aanii APEdist_nnnn ANP ATPlike 6 - 295 0 None None Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 3DAKC 2.25 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 7 - 295 0 None None Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 3DAKD 2.25 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_nooo ANP ATPlike 7 - 295 0 None None Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 2VWIB 2.15 Inactive DFGin‑BLBtrans out-out out-none nonTYR APEdihe_aanii APEdist_nnnn ANP ATPlike 9 - 292 0 None None Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 2VWIC 2.15 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo ANP ATPlike 9 - 292 0 None None Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 2VWID 2.15 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ANP ATPlike 6 - 298 0 None None Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 2VWIA 2.15 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nnno ANP ATPlike 13 - 292 0 None None Serine/threonine-protein kinase OSR1
STE PAK1 PAK1_HUMAN 3Q4ZA 1.887 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 251 - 545 0 None S259I,K299R,D389N,L516I Serine/threonine-protein kinase PAK 1
STE PAK4 PAK4_HUMAN 4FIFA 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 296 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIFB 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 297 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIGA 3.01 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 298 - 590 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4JDIA 1.85 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 5UPKB 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 300 - 588 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIEA 3.11 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 49 - 590 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIEB 3.11 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 49 - 590 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 7S46A 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 300 - 589 0 None D440N,S474E Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 7S47A 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 300 - 589 0 None D440N,S474E Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIGB 3.01 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 298 - 590 0 SEP474 None Serine/threonine-protein kinase PAK 4
STE STK24 STK24_HUMAN 4QMLA 1.882 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 30 - 310 0 TPO190 None Serine/threonine-protein kinase 24
STE STK3 STK3_HUMAN 6AO5A 2.955 Inactive DFGin‑BLAplus out-out none-out nonTYR APEdihe_aaioo APEdist_nooo ANP ATPlike 28 - 488 0 None D146N Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 4LGDA 3.05 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioo ANP ATPlike 16 - 488 0 None D146N Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 4LGDB 3.05 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioo ANP ATPlike 10 - 488 0 None D146N Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 4LGDC 3.05 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioo ANP ATPlike 12 - 490 0 None D146N Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 4LGDD 3.05 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioo ANP ATPlike 11 - 489 0 None D146N Serine/threonine-protein kinase 3
STE STRADA STRAA_HUMAN 2WTKB 2.65 Pseudo DFGin‑BLAminus out-none in-out nonTYR APEdihe_aaoai APEdist_iooo ANP ATPlike 61 - 431 0 None None STE20-related kinase adapter protein alpha
STE STRADA STRAA_HUMAN 2WTKE 2.65 Pseudo DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaoai APEdist_iooo ANP ATPlike 60 - 431 0 None None STE20-related kinase adapter protein alpha
STE TNIK TNIK_HUMAN 7XZRB 2.26 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 12 - 312 0 TPO181,TPO187 None TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 7XZRA 2.26 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP Type1.5_Front 12 - 310 0 TPO181,TPO187 None TRAF2 and NCK-interacting protein kinase
TKL ACVR1 ACVR1_HUMAN 6UNQA 2.4 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi ANP ATPlike 206 - 496 0 None K493A Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 6UNRA 2.2 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi ANP ATPlike 208 - 496 0 None None Activin receptor type-1
TKL ARAF ARAF_HUMAN 9AXMB 2.42 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaioi APEdist_nnni ANP ATPlike 302 - 574 0 None Y301D,Y302D Serine/threonine-protein kinase A-Raf
TKL BRAF BRAF_HUMAN 9AXXB 2.07 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 449 - 721 0 None None Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 9AXYA 3.6 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 448 - 722 0 None None Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 6PP9A 2.59 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 447 - 722 0 None None Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 6V2WA 3.12 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 447 - 721 0 None None Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0TA 3.19 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioo APEdist_iooo ANP ATPlike 448 - 721 0 None None Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0UA 3.09 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 449 - 722 0 None None Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0VA 3.16 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_iooo ANP ATPlike 449 - 722 0 None None Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0WA 3.09 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 448 - 721 0 None None Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0XA 2.47 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 447 - 722 0 None None Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0YA 3.45 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 447 - 721 0 None None Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0ZA 3.12 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_iooo ANP ATPlike 449 - 721 0 None None Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 9ECUA 3.46 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ANP ATPlike 447 - 722 0 None None Serine/threonine-protein kinase B-raf
TKL IRAK4 IRAK4_HUMAN 2OIDA 2.3 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OIDB 2.3 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OIDC 2.3 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 166 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OIDD 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6EGFB 2.61 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn ANP ATPlike 164 - 460 0 None None Interleukin-1 receptor-associated kinase 4
TKL KSR1 KSR1_HUMAN 9AXHC 2.81 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ANP ATPlike 614 - 881 0 None None Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 9AXHD 2.81 Pseudo DFGin‑BLBplus out-none none-out nonTYR APEdihe_aaoai APEdist_oooo ANP ATPlike 613 - 881 0 None None Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JUWB 2.88 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ANP ATPlike 601 - 881 0 None None Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JUXA 3.34 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ANP ATPlike 600 - 881 0 None None Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JUYB 3.096 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ANP ATPlike 601 - 881 0 None None Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JUZA 3.21 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ANP ATPlike 601 - 881 0 None None Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JV0A 3.63 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ANP ATPlike 601 - 881 0 None None Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JV1D 3.62 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ANP ATPlike 600 - 881 0 None None Kinase suppressor of Ras 1
TKL KSR2 KSR2_HUMAN 7JURB 2.82 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ANP ATPlike 652 - 932 0 None None Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JUSB 2.99 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ANP ATPlike 652 - 932 0 None None Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JUTB 3.09 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ANP ATPlike 652 - 932 0 None None Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JUUB 3.19 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ANP ATPlike 652 - 932 0 None None Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JUVB 3.36 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ANP ATPlike 652 - 932 0 None None Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7UMBB 3.231 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ANP ATPlike 652 - 932 0 None None Kinase suppressor of Ras 2
TKL LIMK1 LIMK1_HUMAN 5HVJA 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiai APEdist_oiio ANP ATPlike 329 - 633 0 None D460N LIM domain kinase 1
TKL LIMK1 LIMK1_HUMAN 5HVKA 3.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiai APEdist_iiii ANP ATPlike 329 - 634 0 TPO508 D460N LIM domain kinase 1
TKL LIMK1 LIMK1_HUMAN 5HVKC 3.5 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiai APEdist_iiii ANP ATPlike 329 - 633 0 TPO508 D460N LIM domain kinase 1
TKL LRRK2 LRRK2_HUMAN 8VH5A 4.0 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioi ANP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8VH5C 4.0 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioi ANP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8VH4A 4.1 Inactive None‑None out-none out-out nonTYR APEdihe_aaioi APEdist_iioi ANP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
TKL RAF1 RAF1_HUMAN 9AY7A 2.41 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ANP ATPlike 343 - 612 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase
TKL TGFBR2 TGFR2_HUMAN 5E92A 2.08 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 240 - 543 0 None E431A,R433A,E485A,K488A,R493A,R495A TGF-beta receptor type-2
TYR EGFR EGFR_HUMAN 3VJNA 2.34 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 697 - 1018 0 None G719S,T790M Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8DSWA 2.39 None DFGin‑BLAminus none-none in-none TYR APEdihe_nniai APEdist_aaai ANP ATPlike 696 - 1017 0 None None Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITXA 2.98 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 697 - 1019 0 None None Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3VJOA 2.64 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 696 - 1018 0 None None Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITNA 2.47 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai ANP ATPlike 696 - 1019 0 None G719S Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITVA 2.47 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai ANP ATPlike 696 - 1019 0 None L858R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2EB3A 2.84 Inactive DFGin‑BLAplus in-in in-none TYR APEdihe_nniai APEdist_aaai ANP ATPlike 696 - 1018 0 None None Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1LB 2.8 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao ANP ATPlike 702 - 1008 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6WAKA 2.4 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaai ANP ATPlike 702 - 1013 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6WAKD 2.4 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao ANP ATPlike 701 - 1014 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8FV3A 2.1 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 701 - 1014 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8FV4C 2.2 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao ANP ATPlike 702 - 1013 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO3B 2.49 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao ANP ATPlike 702 - 1014 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO4B 2.99 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nniai APEdist_aaai ANP ATPlike 702 - 1014 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4ZSED 1.97 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai ANP ATPlike 701 - 1015 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5D41B 2.31 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_niiai APEdist_aaao ANP ATPlike 701 - 1014 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5X2AD 1.85 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_niiai APEdist_aaao ANP ATPlike 701 - 1014 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXKB 3.1 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nniai APEdist_aaai ANP ATPlike 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXMC 2.192 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai ANP ATPlike 702 - 1006 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CNOB 1.55 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_niiai APEdist_aaao ANP ATPlike 698 - 1015 0 None V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CNNA 1.9 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 699 - 1014 0 None I706Q Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1DB 2.4 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao ANP, NQ1 ATPlike, Type3 702 - 1013 0 None None Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1LA 2.8 Inactive DFGin‑BLBplus out-out none-out TYR APEdihe_nniai APEdist_aaao ANP, 9LL ATPlike, Type3 701 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1LC 2.8 Inactive DFGin‑BLBplus out-out none-out TYR APEdihe_nniai APEdist_aaao ANP, 9LL ATPlike, Type3 702 - 1005 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1LD 2.8 Inactive DFGin‑BLBplus out-out none-out TYR APEdihe_nniai APEdist_aaao ANP, 9LL ATPlike, Type3 702 - 1015 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P8QA 1.9 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai ANP, O57 ATPlike, Type3 699 - 1019 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6XL4D 2.06 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai ANP, NQ1 ATPlike, Type3 700 - 1013 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO4C 2.99 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nniai APEdist_aaai ANP, IXR ATPlike, Type3 702 - 1013 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO4D 2.99 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nniai APEdist_aaai ANP, IXR ATPlike, Type3 702 - 1005 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5D41A 2.31 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nniai APEdist_aaai ANP, 57N ATPlike, Type3 698 - 1014 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6DUKA 2.2 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaai ANP, JBJ ATPlike, Type3 701 - 1006 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6DUKB 2.2 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai ANP, JBJ ATPlike, Type3 699 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6DUKC 2.2 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai ANP, JBJ ATPlike, Type3 699 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6DUKD 2.2 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaai ANP, JBJ ATPlike, Type3 701 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6DUKE 2.2 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_niiai APEdist_aaai ANP, JBJ ATPlike, Type3 698 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6DUKF 2.2 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai ANP, JBJ ATPlike, Type3 701 - 1009 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXKD 3.1 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai ANP, JBJ ATPlike, Type3 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXMD 2.192 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nniai APEdist_aaai ANP, 9LL ATPlike, Type3 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXPA 2.16 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaai ANP, JBJ ATPlike, Type3 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXPB 2.16 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaai ANP, JBJ ATPlike, Type3 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXPD 2.16 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai ANP, JBJ ATPlike, Type3 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXPF 2.16 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai ANP, JBJ ATPlike, Type3 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXQB 1.83 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_niiai APEdist_aaai ANP, VNS ATPlike, Type3 701 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXQD 1.83 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai ANP, VNS ATPlike, Type3 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7LTXA 2.3 Inactive DFGin‑BLBplus out-out none-out TYR APEdihe_nniai APEdist_aaao ANP, YFA ATPlike, Type3 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7LTXB 2.3 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai ANP, YFA ATPlike, Type3 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7LTXC 2.3 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nniai APEdist_aaai ANP, YFA ATPlike, Type3 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7LTXD 2.3 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai ANP, YFA ATPlike, Type3 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8GB4A 2.59 Inactive DFGin‑BLBplus out-out none-out TYR APEdihe_nniai APEdist_aaao ANP, YW5 ATPlike, Type3 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8GB4B 2.59 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan ANP, YW5 ATPlike, Type3 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8GB4C 2.59 Inactive DFGin‑BLBplus out-out none-out TYR APEdihe_nniai APEdist_aaao ANP, YW5 ATPlike, Type3 700 - 1012 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8GB4D 2.59 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan ANP, YW5 ATPlike, Type3 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7K1IA 3.202 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nniai APEdist_aaai ANP, VNS ATPlike, Type3 700 - 1007 0 None L858R,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1DC 2.4 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai NQ1, ANP Type3, ATPlike 702 - 1006 0 None None Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1DD 2.4 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai NQ1, ANP Type3, ATPlike 701 - 1008 0 None None Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXQA 1.83 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_niiai APEdist_aaao VNS, ANP Type3, ATPlike 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXQC 1.83 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai VNS, ANP Type3, ATPlike 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1DA 2.4 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 700 - 1021 0 None None Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6WAKB 2.4 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 701 - 1020 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6WXNB 1.76 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 701 - 1021 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8FV3B 2.1 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 701 - 1021 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8FV3D 2.1 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 701 - 1008 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8FV4A 2.2 Inactive DFGin‑BLBtrans out-out out-out TYR APEdihe_nniai APEdist_aaao ANP ATPlike 701 - 1013 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO3C 2.49 Inactive DFGin‑BLBtrans out-out out-out TYR APEdihe_nniai APEdist_aaao ANP ATPlike 702 - 1014 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO3D 2.49 Inactive DFGin‑BLBtrans out-out out-out TYR APEdihe_nniai APEdist_aaao ANP ATPlike 702 - 1008 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO4A 2.99 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_nniai APEdist_aaai ANP ATPlike 701 - 1021 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4ZSEA 1.97 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 699 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4ZSEB 1.97 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 698 - 1022 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4ZSEC 1.97 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_nniai APEdist_aaai ANP ATPlike 700 - 1013 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXMA 2.192 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_nniai APEdist_aaai ANP ATPlike 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2GS7A 2.6 Inactive DFGin‑BLBtrans out-out out-out TYR APEdihe_niiai APEdist_aaao ANP ATPlike 703 - 1012 0 None V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2GS7B 2.6 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 701 - 1016 0 None V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3GT8A 2.955 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 700 - 1014 0 None V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3GT8B 2.955 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 701 - 1007 0 None V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3GT8C 2.955 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_nniai APEdist_aaai ANP ATPlike 699 - 1007 0 None V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3GT8D 2.955 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 701 - 1010 0 None V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CNOA 1.55 Inactive DFGin‑BLBtrans out-out out-out TYR APEdihe_niiai APEdist_aaao ANP ATPlike 700 - 1015 0 None V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CNNB 1.9 Inactive DFGin‑BLBtrans out-out out-out TYR APEdihe_niiai APEdist_aaao ANP ATPlike 700 - 1014 0 None I706Q Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5X2AB 1.85 Inactive DFGin‑BLBtrans out-out out-out TYR APEdihe_oiiai APEdist_aaai 7XO, ANP Type1, ATPlike 700 - 1022 0 None T790M,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5X2AA 1.85 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_nniai APEdist_aaai 7XO, ANP Type1, Allosteric 700 - 1011 0 None T790M,V948R Epidermal growth factor receptor
TYR EPHA2 EPHA2_HUMAN 1MQBA 2.3 Inactive DFGin‑BLAminus in-out none-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 605 - 887 0 None None Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 1MQBB 2.3 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 602 - 883 0 None None Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 5I9WA 1.359 Inactive DFGin‑BLBminus in-in none-none TYR APEdihe_nniai APEdist_aaai ANP ATPlike 605 - 895 0 None None Ephrin type-A receptor 2
TYR EPHA3 EPHA3_HUMAN 2QOCA 1.25 Inactive DFGin‑BLAminus in-out in-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 613 - 906 0 None None Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 3FXXA 1.7 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 606 - 904 0 None A608T Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2QO7A 1.605 Inactive DFGin‑BLAminus in-out none-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 595 - 904 0 PTR701 None Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2QO9A 1.55 Inactive DFGin‑BLAminus in-out in-out TYR APEdihe_noiai APEdist_aaai ANP ATPlike 608 - 904 0 None None Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2QOQA 1.6 None DFGin‑BLAminus in-in none-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 595 - 906 0 PTR701 None Ephrin type-A receptor 3
TYR ERBB3 ERBB3_HUMAN 3KEXA 2.797 Pseudo DFGin‑BLBplus out-na out-out TYR APEdihe_nnoai APEdist_aaao ANP ATPlike 698 - 994 0 None None Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 3KEXB 2.797 Pseudo DFGin‑BLBplus out-na out-out TYR APEdihe_nnoai APEdist_aaao ANP ATPlike 698 - 988 0 None None Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIWA 3.1 Pseudo DFGin‑BLBplus out-na out-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 699 - 979 0 None None Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIWC 3.1 Pseudo DFGin‑BLBplus out-na out-out TYR APEdihe_oioai APEdist_aaao ANP ATPlike 699 - 979 0 None None Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 3LMGA 2.8 Pseudo DFGin‑BLBplus out-na out-out TYR APEdihe_nnoai APEdist_aaao ANP ATPlike 699 - 978 0 None None Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 3LMGB 2.8 Pseudo DFGin‑BLBplus out-na out-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 699 - 978 0 None None Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIYA 2.981 Pseudo DFGin‑BLBplus out-na out-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 699 - 979 0 None E928G Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIYC 2.981 Pseudo DFGin‑BLBplus out-na out-out TYR APEdihe_oioai APEdist_aaao ANP ATPlike 699 - 979 0 None E928G Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIXA 3.1 Pseudo DFGin‑BLBplus out-na out-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 699 - 979 0 None Q809R Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIXC 3.1 Pseudo DFGin‑BLBplus out-na out-out TYR APEdihe_oioai APEdist_aaao ANP ATPlike 699 - 979 0 None Q809R Receptor tyrosine-protein kinase erbB-3
TYR FGFR2 FGFR2_HUMAN 5UGLA 1.861 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ANP ATPlike 468 - 764 0 None D650V Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5UGLB 1.861 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ANP ATPlike 467 - 764 0 None D650V Fibroblast growth factor receptor 2
TYR HCK HCK_HUMAN 1AD5A 2.6 Inactive DFGin‑BLAminus out-out out-out TYR APEdihe_iioai APEdist_aaao ANP ATPlike 79 - 526 0 PTR522 None Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 1AD5B 2.6 Inactive DFGin‑BLAminus out-out out-out TYR APEdihe_iioai APEdist_aaao ANP ATPlike 79 - 526 0 PTR522 None Tyrosine-protein kinase HCK
TYR IGF1R IGF1R_HUMAN 1JQHA 2.1 Inactive DFGin‑None in-out none-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 984 - 1286 0 None E979G,Y980S Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 1JQHB 2.1 Inactive DFGin‑None in-out none-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 984 - 1286 0 None E979G,Y980S Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 1JQHC 2.1 Inactive DFGin‑None in-out none-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 984 - 1286 0 None E979G,Y980S Insulin-like growth factor 1 receptor
TYR INSR INSR_HUMAN 1IR3A 1.9 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 1008 - 1310 0 PTR1185,PTR1189,PTR1190 C1008S,Y1011F Insulin receptor
TYR LCK LCK_HUMAN 1QPCA 1.6 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 231 - 502 0 PTR394 None Tyrosine-protein kinase Lck
TYR MERTK MERTK_HUMAN 2P0CA 2.4 Inactive DFGin‑BLBplus out-none none-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 575 - 861 0 None None Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 2P0CB 2.4 Inactive DFGin‑BLBplus out-none none-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 575 - 861 0 None None Tyrosine-protein kinase Mer
TYR MST1R RON_HUMAN 3PLSA 2.24 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oioai APEdist_aaao ANP ATPlike 1060 - 1357 0 None M1254T Macrophage-stimulating protein receptor
TYR MST1R RON_HUMAN 8ZKDA 2.05 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_iooai APEdist_aaao ANP ATPlike 1060 - 1357 0 None None Macrophage-stimulating protein receptor
TYR SRC SRC_HUMAN 2SRCA 1.5 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao ANP ATPlike 87 - 536 0 PTR530 None Proto-oncogene tyrosine-protein kinase Src
TYR SYK KSYK_HUMAN 4FL1A 1.79 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 363 - 635 0 None None Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4FL3A 1.9 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 9 - 635 0 None Y348F,Y352F Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4FL2A 2.19 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_iioai APEdist_aaao ANP ATPlike 9 - 635 0 None None Tyrosine-protein kinase SYK
TYR ZAP70 ZAP70_HUMAN 2OZOA 2.6 Inactive DFGin‑BLAplus out-out out-out TYR APEdihe_nnnao APEdist_aaan ANP ATPlike 2 - 606 0 None Y315F,Y319F,D461N Tyrosine-protein kinase ZAP-70
TYR ZAP70 ZAP70_HUMAN 4K2RA 3.0 Inactive DFGin‑BLAplus out-out none-out TYR APEdihe_nnoai APEdist_aaao ANP ATPlike 2 - 606 0 None D461N Tyrosine-protein kinase ZAP-70

Ligand: ANP

Total number of chains: 536
Active chains: 102
Total number of genes: 123
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 231 43.1% 8QCGA
DFGin BLBplus 158 29.5% 2SRCA
DFGin None 35 6.5% 6BXIA
DFGin ABAminus 34 6.3% 8R5EA
DFGin BLBtrans 34 6.3% 5X2AB
None None 12 2.2% 4IX5A
DFGin BLBminus 11 2.1% 4LGDA
DFGinter None 10 1.9% 7OPOG
DFGout None 6 1.1% 4I94A
DFGin BLAplus 5 0.9% 2OZOA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC CKA1 CSK21_ARATH 6XX7A 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 77 - 406 0 None None Casein kinase II subunit alpha-1 Arabidopsis thaliana
CMGC MPK4 MPK4_ARATH 7W5CA 2.201 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oioo ANP ATPlike 18 - 372 0 None None Mitogen-activated protein kinase 4 Arabidopsis thaliana
OTHER BSK8 BSK8_ARATH 4I94A 1.8 Pseudo DFGout‑None out-out out-out nonTYR APEdihe_aaiai APEdist_iioo ANP ATPlike 40 - 328 0 None None Serine/threonine-protein kinase BSK8 Arabidopsis thaliana
OTHER BSK8 BSK8_ARATH 4I94B 1.8 Pseudo DFGout‑None out-out out-out nonTYR APEdihe_aaiai APEdist_iioo ANP ATPlike 40 - 328 0 None None Serine/threonine-protein kinase BSK8 Arabidopsis thaliana
TKL BAK1 BAK1_ARATH 3UIMA 2.2 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaini APEdist_iiii ANP ATPlike 272 - 573 0 SEP290,TPO312,TPO446,TPO449,TPO450,TPO455 None BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 Arabidopsis thaliana
TKL BRI1 BRI1_ARATH 5LPVA 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 867 - 1160 0 TPO1039,SEP1042,SEP1044 T872A Protein BRASSINOSTEROID INSENSITIVE 1 Arabidopsis thaliana
TKL BRI1 BRI1_ARATH 4OH4A 2.25 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 863 - 1160 0 TPO1039,SEP1042,SEP1044,SEP1060 None Protein BRASSINOSTEROID INSENSITIVE 1 Arabidopsis thaliana
TKL BRI1 BRI1_ARATH 4OH4B 2.25 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 867 - 1160 0 TPO1039,SEP1042,SEP1044,SEP1060 None Protein BRASSINOSTEROID INSENSITIVE 1 Arabidopsis thaliana
TKL BRI1 BRI1_ARATH 4Q5JA 2.772 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 863 - 1160 0 TPO1039,SEP1042,SEP1044,SEP1060 None Protein BRASSINOSTEROID INSENSITIVE 1 Arabidopsis thaliana
TKL BRI1 BRI1_ARATH 4Q5JB 2.772 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 867 - 1160 0 TPO1039,SEP1042,SEP1044,SEP1060 None Protein BRASSINOSTEROID INSENSITIVE 1 Arabidopsis thaliana
TKL CARK1 CARK1_ARATH 5XD6A 1.898 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 50 - 350 0 None None Protein CYTOSOLIC ABA RECEPTOR KINASE 1 Arabidopsis thaliana
TKL CARK1 CARK1_ARATH 5XD6B 1.898 Inactive DFGin‑None out-na none-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 50 - 350 0 None None Protein CYTOSOLIC ABA RECEPTOR KINASE 1 Arabidopsis thaliana
TKL SOBIR1 SBIR1_ARATH 7CTVA 2.886 Inactive DFGin‑BLBminus out-none out-out nonTYR APEdihe_aaooi APEdist_oooo ANP ATPlike 326 - 639 0 None D489A Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1 Arabidopsis thaliana
TKL SOBIR1 SBIR1_ARATH 7CTVB 2.886 Inactive DFGin‑BLBminus out-none out-out nonTYR APEdihe_aaooi APEdist_oooo ANP ATPlike 326 - 640 0 None D489A Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1 Arabidopsis thaliana
TKL SOBIR1 SBIR1_ARATH 7CTXA 2.907 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooi APEdist_oooo ANP ATPlike 326 - 639 0 None None Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1 Arabidopsis thaliana
TKL SOBIR1 SBIR1_ARATH 7CTXB 2.907 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooi APEdist_oooo ANP ATPlike 326 - 640 0 None None Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1 Arabidopsis thaliana
AGC PRKACA KAPCA_BOVIN 9DW5G 3.8 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 13 - 351 0 TPO198 None cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
AGC PRKACA KAPCA_BOVIN 9DW8G 3.5 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 15 - 329 0 TPO198 None cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
AGC PRKACA KAPCA_BOVIN 9DW7G 6.0 Inactive None‑None out-none in-out nonTYR APEdihe_aaini APEdist_iiio ANP ATPlike 13 - 351 0 None None cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
TYR LET23 LET23_CAEEL 5WNOA 2.386 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nooai APEdist_aaao ANP ATPlike 876 - 1190 0 None None Receptor tyrosine-protein kinase let-23 Caenorhabditis elegans
CMGC CK2 Q5KF69_CRYD1 6ISEA 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 5 - 331 0 None None Casein kinase II subunit alpha Cryptococcus deneoformans
CMGC CK2 Q5KF69_CRYD1 6ISEB 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 5 - 331 0 None None Casein kinase II subunit alpha Cryptococcus deneoformans
CMGC CKA1 J9VNH4_CRYN9 6KO6B 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 5 - 334 0 None None Casein kinase II subunit alpha Cryptococcus neoformans
CAMK CDPK1 A3FQ16_CRYPI 3IGOA 2.25 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn ANP ATPlike 70 - 537 0 None None non-specific serine/threonine protein kinase Cryptosporidium parvum
CAMK CDPK3 Q5CS01_CRYPI 3LIJA 1.9 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 42 - 516 0 None None Calcium-dependent protein kinase 1 Cryptosporidium parvum
CAMK CDPK4-2 Q5CZ29_CRYPI 3HKOA 1.8 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaiii APEdist_nnoi ANP ATPlike 126 - 452 0 None None non-specific serine/threonine protein kinase Cryptosporidium parvum
CMGC BSK JNK_DROME 5AWMA 1.79 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo ANP ATPlike 7 - 362 0 None None Stress-activated protein kinase JNK Drosophila melanogaster
STE DSOR1 DSOR1_DROME 8BW9C 3.32 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, QOM ATPlike, Type3 81 - 384 0 None None Dual specificity mitogen-activated protein kinase kinase dSOR1 Drosophila melanogaster
TYR PTK2 FAK1_CHICK 2J0LA 2.3 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao ANP ATPlike 411 - 686 0 PTR576,PTR577 None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 6TY4A 5.96 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 34 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 6TY4B 5.96 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 34 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
AGC AKT1 AKT1_HUMAN 4EKKA 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 144 - 477 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase Homo sapiens
AGC AKT1 AKT1_HUMAN 4EKKB 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 144 - 477 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase Homo sapiens
AGC AKT2 AKT2_HUMAN 1O6KA 1.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 146 - 479 0 TPO309 S474D RAC-beta serine/threonine-protein kinase Homo sapiens
AGC AKT2 AKT2_HUMAN 1O6LA 1.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 146 - 477 0 TPO309 None RAC-beta serine/threonine-protein kinase Homo sapiens
AGC GRK5 GRK5_HUMAN 4TNDA 1.802 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 15 - 543 0 None None G protein-coupled receptor kinase 5 Homo sapiens
AGC GRK6 GRK6_HUMAN 2ACXA 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 14 - 532 0 None C561S,C562S,C565S G protein-coupled receptor kinase 6 Homo sapiens
AGC GRK6 GRK6_HUMAN 2ACXB 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 14 - 535 0 None C561S,C562S,C565S G protein-coupled receptor kinase 6 Homo sapiens
AGC PRKCB KPCB_HUMAN 8SE1A 3.32 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 19 - 668 0 TPO500,TPO642,SEP661 None Protein kinase C beta type Homo sapiens
AGC PRKCB KPCB_HUMAN 8SE1B 3.32 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 19 - 668 0 TPO500,TPO642,SEP661 None Protein kinase C beta type Homo sapiens
AGC PRKCB KPCB_HUMAN 8SE2B 2.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 30 - 671 0 TPO500,TPO642,SEP661 None Protein kinase C beta type Homo sapiens
AGC PRKCI KPCI_HUMAN 8R3YI 3.68 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 248 - 585 0 TPO412,TPO564 None Protein kinase C iota type Homo sapiens
AGC PRKCI KPCI_HUMAN 5LI1A 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 248 - 589 0 TPO412,SEP484,TPO564 None Protein kinase C iota type Homo sapiens
AGC PRKG1 KGP1_HUMAN 6BG2A 1.83 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 336 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
AGC PRKG1 KGP1_HUMAN 6BG2B 1.83 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 346 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
AGC PRKG1 KGP1_HUMAN 6BG2C 1.83 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 337 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
AGC PRKG1 KGP1_HUMAN 6BG2D 1.83 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 344 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
AGC PRKG1 KGP1_HUMAN 7LV3A 2.41 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 57 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
AGC PRKG1 KGP1_HUMAN 7LV3B 2.41 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 58 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
AGC ROCK1 ROCK1_HUMAN 2V55A 3.705 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 6 - 404 0 None None Rho-associated protein kinase 1 Homo sapiens
AGC ROCK1 ROCK1_HUMAN 2V55C 3.705 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 6 - 404 0 None None Rho-associated protein kinase 1 Homo sapiens
AGC RPS6KA1-1 KS6A1_HUMAN 8XOVA 2.55 Inactive DFGin‑BLAplus out-out out-out nonTYR APEdihe_aaiii APEdist_nioo ANP ATPlike 56 - 340 0 None None Ribosomal protein S6 kinase alpha-1 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOA 2.75 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aanoi APEdist_oonn ANP ATPlike 45 - 348 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOE 2.75 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aanoi APEdist_oonn ANP ATPlike 46 - 348 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOI 2.75 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aanoi APEdist_onnn ANP ATPlike 46 - 348 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOK 2.75 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aanoi APEdist_oonn ANP ATPlike 46 - 348 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOC 2.75 Inactive DFGinter‑None none-none out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 46 - 347 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOG 2.75 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanni APEdist_oonn ANP ATPlike 46 - 348 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA6-1 KS6A6_HUMAN 6G77A 2.499 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aaiii APEdist_iooi ANP, ANP Allosteric, ATPlike 51 - 349 0 None None Ribosomal protein S6 kinase alpha-6 Homo sapiens
AGC RPS6KA6-1 KS6A6_HUMAN 6G77B 2.499 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aaiii APEdist_iooi ANP, ANP Allosteric, ATPlike 51 - 349 0 None None Ribosomal protein S6 kinase alpha-6 Homo sapiens
AGC RPS6KA6-1 KS6A6_HUMAN 6G76B 3.0 Inactive DFGinter‑None none-none out-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 51 - 349 0 SEP232 None Ribosomal protein S6 kinase alpha-6 Homo sapiens
AGC RPS6KA6-1 KS6A6_HUMAN 6G78A 2.5 Inactive DFGinter‑None none-none out-out nonTYR APEdihe_aaoii APEdist_nnno ANP ATPlike 51 - 349 0 None S232E Ribosomal protein S6 kinase alpha-6 Homo sapiens
AGC RPS6KA6-1 KS6A6_HUMAN 6G78B 2.5 Inactive DFGinter‑None none-none out-out nonTYR APEdihe_aaiii APEdist_nnno ANP ATPlike 51 - 349 0 None S232E Ribosomal protein S6 kinase alpha-6 Homo sapiens
AGC RPS6KA6-1 KS6A6_HUMAN 6G76A 3.0 Inactive DFGinter‑None none-none out-out nonTYR APEdihe_aaiii APEdist_iooi ANP, ANP ATPlike, Allosteric 51 - 349 0 SEP232 None Ribosomal protein S6 kinase alpha-6 Homo sapiens
AGC SGK1 SGK1_HUMAN 2R5TA 1.9 Inactive DFGinter‑None none-none out-out nonTYR APEdihe_aaiio APEdist_oooo ANP ATPlike 82 - 378 0 None S74A,S78A,S397A,S401A Serine/threonine-protein kinase Sgk1 Homo sapiens
AGC STK38 STK38_HUMAN 6BXIA 2.2 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 82 - 414 0 None None Serine/threonine-protein kinase 38 Homo sapiens
AGC STK38 STK38_HUMAN 6BXIB 2.2 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 83 - 414 0 None None Serine/threonine-protein kinase 38 Homo sapiens
CAMK AURKA AURKA_HUMAN 2DWBA 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ANP ATPlike 126 - 389 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 6VPGA 2.64 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 7 - 389 0 TPO287,TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 6VPIA 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iioo ANP ATPlike 104 - 389 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 6VPLA 1.86 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_oooo ANP, R7D ATPlike, Allosteric 7 - 389 0 TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 6VPLB 1.86 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_oooo ANP, R7D ATPlike, Allosteric 7 - 389 0 TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 2C6DA 2.2 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno ANP ATPlike 126 - 390 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 6VPJA 2.1 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaooi APEdist_iioo ANP ATPlike 104 - 389 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 6VPHA 2.14 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo ANP ATPlike 7 - 389 0 TPO287,TPO288 None Aurora kinase A Homo sapiens
CAMK CASK CSKP_HUMAN 3MFRA 2.0 Pseudo DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 5 - 306 0 None P22A,H145E,C146N,G162D Peripheral plasma membrane protein CASK Homo sapiens
CAMK CASK CSKP_HUMAN 3MFSA 2.1 Pseudo DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 4 - 306 0 None P22A,H145E,C146N,G162D Peripheral plasma membrane protein CASK Homo sapiens
CAMK CASK CSKP_HUMAN 3MFUA 2.3 Pseudo DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 5 - 306 0 None P22A,H145E,C146N,G162D Peripheral plasma membrane protein CASK Homo sapiens
CAMK CASK CSKP_HUMAN 9M6GA 1.7 Pseudo DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 5 - 312 0 None None Peripheral plasma membrane protein CASK Homo sapiens
CAMK CASK CSKP_HUMAN 9M5YA 1.8 Pseudo DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 3 - 312 0 None None Peripheral plasma membrane protein CASK Homo sapiens
CAMK CHEK1 CHK1_HUMAN 5OOPA 1.7 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 5 - 271 0 None N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S Serine/threonine-protein kinase Chk1 Homo sapiens
CAMK DAPK1 DAPK1_HUMAN 1IG1A 1.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ANP ATPlike 2 - 294 0 None None Death-associated protein kinase 1 Homo sapiens
CAMK DAPK1 DAPK1_HUMAN 1JKKA 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ANP ATPlike 2 - 293 0 None None Death-associated protein kinase 1 Homo sapiens
CAMK DAPK1 DAPK1_HUMAN 1JKLA 1.62 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ANP ATPlike 2 - 294 0 None None Death-associated protein kinase 1 Homo sapiens
CAMK DAPK1 DAPK1_HUMAN 3EHAA 1.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ANP ATPlike 2 - 277 0 None None Death-associated protein kinase 1 Homo sapiens
CAMK DAPK1 DAPK1_HUMAN 3F5UA 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ANP ATPlike 2 - 277 0 None None Death-associated protein kinase 1 Homo sapiens
CAMK DAPK1 DAPK1_HUMAN 3DFCB 1.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ANP ATPlike 2 - 277 0 None Q23K Death-associated protein kinase 1 Homo sapiens
CAMK DAPK1 DAPK1_HUMAN 3GU4A 1.35 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ANP ATPlike 2 - 277 0 None Q23V Death-associated protein kinase 1 Homo sapiens
CAMK DAPK1 DAPK1_HUMAN 3GU5A 1.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ANP ATPlike 2 - 277 0 None Q23V Death-associated protein kinase 1 Homo sapiens
CAMK MELK MELK_HUMAN 4BL1A 2.6 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn ANP ATPlike 2 - 333 0 None None Maternal embryonic leucine zipper kinase Homo sapiens
CAMK PIM1 PIM1_HUMAN 1YXTA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 33 - 306 0 None None Serine/threonine-protein kinase pim-1 Homo sapiens
CAMK PIM1 PIM1_HUMAN 1XR1A 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 32 - 308 0 None None Serine/threonine-protein kinase pim-1 Homo sapiens
CAMK PIM1 PIM1_HUMAN 3A99A 1.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 33 - 305 0 None None Serine/threonine-protein kinase pim-1 Homo sapiens
CAMK PIM1 PIM1_HUMAN 2BZKB 2.45 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 33 - 305 0 None R250G Serine/threonine-protein kinase pim-1 Homo sapiens
CAMK PLK1 PLK1_HUMAN 8X72A 2.2 Inactive DFGin‑BLAminus out-in in-out nonTYR APEdihe_aaiio APEdist_ioio ANP ATPlike 37 - 330 0 None None Serine/threonine-protein kinase PLK1 Homo sapiens
CAMK PLK1 PLK1_HUMAN 2OU7A 2.4 Inactive DFGin‑BLAminus out-in in-out nonTYR APEdihe_aaiio APEdist_ioio ANP ATPlike 37 - 328 0 None T210V Serine/threonine-protein kinase PLK1 Homo sapiens
CAMK PLK4 PLK4_HUMAN 3COKA 2.25 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 2 - 266 0 None None Serine/threonine-protein kinase PLK4 Homo sapiens
CAMK PLK4 PLK4_HUMAN 3COKB 2.25 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 2 - 266 0 None None Serine/threonine-protein kinase PLK4 Homo sapiens
CAMK RPS6KA5-2 KS6A5_HUMAN 3KN5A 2.4 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 415 - 729 0 None None Ribosomal protein S6 kinase alpha-5 Homo sapiens
CAMK RPS6KA5-2 KS6A5_HUMAN 3KN5B 2.4 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 415 - 729 0 None None Ribosomal protein S6 kinase alpha-5 Homo sapiens
CAMK STK11 STK11_HUMAN 2WTKC 2.65 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 47 - 342 0 None D194A Serine/threonine-protein kinase STK11 Homo sapiens
CAMK STK11 STK11_HUMAN 2WTKF 2.65 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 45 - 340 0 None D194A Serine/threonine-protein kinase STK11 Homo sapiens
CK1 VRK1 VRK1_HUMAN 6AC9A 2.07 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ANP ATPlike 21 - 342 0 None K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A Serine/threonine-protein kinase VRK1 Homo sapiens
CK1 VRK1 VRK1_HUMAN 6AC9B 2.07 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ANP ATPlike 21 - 341 0 None K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A Serine/threonine-protein kinase VRK1 Homo sapiens
CK1 VRK1 VRK1_HUMAN 6AC9C 2.07 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii ANP ATPlike 24 - 341 0 None K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A Serine/threonine-protein kinase VRK1 Homo sapiens
CK1 VRK1 VRK1_HUMAN 6AC9D 2.07 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii ANP ATPlike 23 - 341 0 None K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A Serine/threonine-protein kinase VRK1 Homo sapiens
CMGC CDK1 CDK1_HUMAN 9SKQA 3.4 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaooo APEdist_iiii ANP ATPlike 3 - 288 0 TPO161 None Cyclin-dependent kinase 1 Homo sapiens
CMGC CDK12 CDK12_HUMAN 4CXAA 3.15 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 718 - 1050 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK2 CDK2_HUMAN 9QCVK 2.5 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iooi ANP ATPlike 1 - 292 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK7 CDK7_HUMAN 8R99A 1.81 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iooi ANP ATPlike 10 - 311 0 None W132R,S164D,T170E Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK7 CDK7_HUMAN 9QCVJ 2.5 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iooi ANP ATPlike 10 - 346 0 None None Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK7 CDK7_HUMAN 9SKQJ 3.4 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iooi ANP ATPlike 9 - 346 0 None None Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK7 CDK7_HUMAN 8R9BA 2.21 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo ANP ATPlike 1 - 311 0 None S164D,T170E Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK7 CDK7_HUMAN 8R9BB 2.21 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo ANP ATPlike 3 - 310 0 None S164D,T170E Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK7 CDK7_HUMAN 8R9BC 2.21 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoii APEdist_nnoo ANP ATPlike 8 - 311 0 None S164D,T170E Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK7 CDK7_HUMAN 8R9BD 2.21 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooi APEdist_nnoo ANP ATPlike 9 - 311 0 None S164D,T170E Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK9 CDK9_HUMAN 3MIAA 3.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 8 - 340 0 TPO186 None Cyclin-dependent kinase 9 Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 3JUHA 1.66 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 2 - 335 0 None V66A,M163L Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 3JUHB 1.66 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 2 - 335 0 None V66A,M163L Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 3NSZA 1.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 2 - 328 0 None None Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 1PJKA 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 2 - 332 0 None None Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 2PVRA 1.605 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 2 - 329 0 None None Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 3WOWA 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 2 - 335 0 None None Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 1JWHA 3.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 2 - 337 0 None None Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 3U87A 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 2 - 331 0 None None Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 3U87B 2.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 2 - 331 0 None None Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A2 CSK22_HUMAN 8QCGA 1.04 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 7 - 330 0 None C336S Casein kinase II subunit alpha' Homo sapiens
CMGC CSNK2A2 CSK22_HUMAN 8QCGB 1.04 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 7 - 333 0 None C336S Casein kinase II subunit alpha' Homo sapiens
CMGC DYRK1A DYR1A_HUMAN 7A4OA 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 136 - 481 0 PTR321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A Homo sapiens
CMGC DYRK1A DYR1A_HUMAN 7A4OB 1.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii ANP ATPlike 134 - 481 0 PTR321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A Homo sapiens
CMGC GSK3B GSK3B_HUMAN 1J1BA 1.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 35 - 388 0 None None Glycogen synthase kinase-3 beta Homo sapiens
CMGC GSK3B GSK3B_HUMAN 1J1BB 1.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 23 - 386 0 None None Glycogen synthase kinase-3 beta Homo sapiens
CMGC GSK3B GSK3B_HUMAN 8XN6A 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 35 - 384 0 None None Glycogen synthase kinase-3 beta Homo sapiens
CMGC GSK3B GSK3B_HUMAN 8XN6B 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 26 - 386 0 None None Glycogen synthase kinase-3 beta Homo sapiens
CMGC GSK3B GSK3B_HUMAN 1PYXA 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 35 - 386 0 None None Glycogen synthase kinase-3 beta Homo sapiens
CMGC GSK3B GSK3B_HUMAN 1PYXB 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 35 - 383 0 None None Glycogen synthase kinase-3 beta Homo sapiens
CMGC MAPK1 MK01_HUMAN 4H3QA 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooo APEdist_iioo ANP ATPlike 9 - 360 0 None R77A,C161S,I255G,E314A Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 6OPGA 2.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 10 - 358 0 TPO185,PTR187 None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 2Y9QA 1.55 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ANP ATPlike 9 - 358 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 4FMQA 2.098 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ANP ATPlike 9 - 358 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 4NIFB 2.15 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ANP ATPlike 9 - 360 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 4NIFE 2.15 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ANP ATPlike 10 - 360 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 8PSRA 1.85 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ANP ATPlike 1 - 358 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 3TEIA 2.404 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ANP ATPlike 10 - 358 0 None R77A,E314A Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 4H3PA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ANP ATPlike 11 - 359 0 None R77A,E314A Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 4H3PD 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn ANP ATPlike 11 - 359 0 None R77A,E314A Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 8PT0A 1.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oioo ANP, EAI ATPlike, Allosteric 11 - 358 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 8PT1A 1.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ANP, E2A ATPlike, Allosteric 11 - 359 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 8PT5A 1.95 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ANP, D5R ATPlike, Allosteric 10 - 358 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 8R5FA 1.65 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno ANP, Y3H ATPlike, Allosteric 11 - 359 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 8PT3A 1.8 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_oiio D7O, ANP Allosteric, ATPlike 10 - 359 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK10 MK10_HUMAN 8WGFA 1.85 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaiii APEdist_oooo ANP ATPlike 44 - 400 0 None None Mitogen-activated protein kinase 10 Homo sapiens
CMGC MAPK10 MK10_HUMAN 1JNKA 2.3 Inactive DFGin‑ABAminus in-out none-out nonTYR APEdihe_aaiii APEdist_oooo ANP ATPlike 45 - 400 0 None None Mitogen-activated protein kinase 10 Homo sapiens
CMGC MAPK10 MK10_HUMAN 4Z9LA 2.1 Inactive DFGin‑ABAminus out-out none-out nonTYR APEdihe_aaiii APEdist_nnno ANP, 880 Allosteric, Type1 45 - 400 0 None None Mitogen-activated protein kinase 10 Homo sapiens
CMGC MAPK12 MK12_HUMAN 1CM8A 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 8 - 353 0 TPO183,PTR185 None Mitogen-activated protein kinase 12 Homo sapiens
CMGC MAPK12 MK12_HUMAN 1CM8B 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 8 - 353 0 TPO183,PTR185 None Mitogen-activated protein kinase 12 Homo sapiens
CMGC MAPK7 MK07_HUMAN 4IC7A 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iooi ANP ATPlike 46 - 400 0 None None Mitogen-activated protein kinase 7 Homo sapiens
CMGC MAPK7 MK07_HUMAN 4IC7D 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iooi ANP ATPlike 47 - 399 0 None None Mitogen-activated protein kinase 7 Homo sapiens
CMGC MAPK8 MK08_HUMAN 6ZR5A 2.699 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn ANP ATPlike 3 - 362 0 None None Mitogen-activated protein kinase 8 Homo sapiens
CMGC MAPK8 MK08_HUMAN 6ZR5B 2.699 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaiii APEdist_oioo ANP ATPlike 4 - 362 0 None None Mitogen-activated protein kinase 8 Homo sapiens
CMGC MAPK8 MK08_HUMAN 2XRWA 1.33 Inactive DFGin‑ABAminus in-out none-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 2 - 364 0 None None Mitogen-activated protein kinase 8 Homo sapiens
CMGC MAPK8 MK08_HUMAN 2XS0A 2.6 Inactive DFGin‑ABAminus in-out none-out nonTYR APEdihe_aanoo APEdist_nnnn ANP ATPlike 6 - 365 0 None T183V,Y185F Mitogen-activated protein kinase 8 Homo sapiens
CMGC MAPK8 MK08_HUMAN 4UX9A 2.34 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 8 - 363 0 None None Mitogen-activated protein kinase 8 Homo sapiens
CMGC MAPK8 MK08_HUMAN 4UX9C 2.34 Inactive DFGin‑ABAminus in-out in-none nonTYR APEdihe_aaiii APEdist_niii ANP ATPlike 8 - 363 0 None None Mitogen-activated protein kinase 8 Homo sapiens
CMGC MAPK8 MK08_HUMAN 4UX9D 2.34 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioo APEdist_oioo ANP ATPlike 9 - 364 0 None None Mitogen-activated protein kinase 8 Homo sapiens
CMGC MAPK8 MK08_HUMAN 8R5EA 1.7 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaiii APEdist_oooo ANP, Y6K ATPlike, Allosteric 5 - 363 0 None None Mitogen-activated protein kinase 8 Homo sapiens
CMGC MAPK8 MK08_HUMAN 4QTDA 1.5 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaiii APEdist_oooo 38Z, ANP Type1, Allosteric 6 - 363 0 None None Mitogen-activated protein kinase 8 Homo sapiens
CMGC MAPK8 MK08_HUMAN 9FT9A 2.35 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_oioo ANP ATPlike 7 - 363 0 None None Mitogen-activated protein kinase 8 Homo sapiens
CMGC MAPK8 MK08_HUMAN 4UX9B 2.34 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 8 - 362 0 None None Mitogen-activated protein kinase 8 Homo sapiens
CMGC PRP4K PRP4K_HUMAN 4IIRA 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oioi ANP ATPlike 668 - 1005 0 PTR849 None Serine/threonine-protein kinase PRP4 homolog Homo sapiens
CMGC PRP4K PRP4K_HUMAN 4IIRB 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oioi ANP ATPlike 670 - 1005 0 PTR849 None Serine/threonine-protein kinase PRP4 homolog Homo sapiens
CMGC SRPK1 SRPK1_HUMAN 3BEGA 2.9 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 69 - 655 0 None None SRSF protein kinase 1 Homo sapiens
OTHER EIF2AK2 E2AK2_HUMAN 2A19B 2.5 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ANP ATPlike 258 - 541 0 TPO446 H412N,C551A Interferon-induced, double-stranded RNA-activated protein kinase Homo sapiens
OTHER EIF2AK2 E2AK2_HUMAN 2A19C 2.5 Inactive DFGin‑ABAminus in-in none-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 258 - 541 0 TPO446 H412N,C551A Interferon-induced, double-stranded RNA-activated protein kinase Homo sapiens
OTHER TP53RK PRPK_HUMAN 6WQXC 2.53 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP ATPlike 17 - 247 0 None None EKC/KEOPS complex subunit TP53RK Homo sapiens
OTHER TP53RK PRPK_HUMAN 6WQXD 2.53 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP ATPlike 18 - 247 0 None None EKC/KEOPS complex subunit TP53RK Homo sapiens
OTHER WNK1 WNK1_HUMAN 5WDYA 2.458 None DFGin‑BLAminus out-na in-none nonTYR APEdihe_aannn APEdist_nnnn ANP, A6S ATPlike, Type3 208 - 481 0 None S378D,E396A,E397A,K398A Serine/threonine-protein kinase WNK1 Homo sapiens
OTHER WNK1 WNK1_HUMAN 5WDYB 2.458 Inactive DFGin‑BLAminus out-na in-out nonTYR APEdihe_aanoo APEdist_nnnn ANP, A6S ATPlike, Type3 206 - 480 0 None S378D,E396A,E397A,K398A Serine/threonine-protein kinase WNK1 Homo sapiens
OTHER WNK1 WNK1_HUMAN 5WE8A 2.006 Inactive DFGin‑BLAminus out-na in-out nonTYR APEdihe_aaioo APEdist_oooo ANP, A7Y ATPlike, Type3 209 - 483 0 None S378D,E396A,E397A,K398A Serine/threonine-protein kinase WNK1 Homo sapiens
OTHER WNK1 WNK1_HUMAN 5WE8B 2.006 Inactive DFGin‑BLAminus out-na in-out nonTYR APEdihe_aaiio APEdist_oooo ANP, A7Y ATPlike, Type3 207 - 480 0 None S378D,E396A,E397A,K398A Serine/threonine-protein kinase WNK1 Homo sapiens
OTHER WNK1 WNK1_HUMAN 5TF9A 2.5 Inactive DFGin‑BLAminus out-na in-out nonTYR APEdihe_aaioo APEdist_nnno 7AV, ANP Type3, ATPlike 210 - 483 0 None None Serine/threonine-protein kinase WNK1 Homo sapiens
OTHER WNK1 WNK1_HUMAN 5TF9B 2.5 Inactive DFGin‑BLAminus out-na in-out nonTYR APEdihe_aaiio APEdist_nnno 7AV, ANP Type3, ATPlike 206 - 480 0 None None Serine/threonine-protein kinase WNK1 Homo sapiens
OTHER WNK3 WNK3_HUMAN 5O26A 2.379 Active DFGin‑BLAminus out-na in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 135 - 414 0 SEP304,SEP308 None Serine/threonine-protein kinase WNK3 Homo sapiens
OTHER WNK3 WNK3_HUMAN 5O26B 2.379 Active DFGin‑BLAminus out-na in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 136 - 413 0 SEP304,SEP308 None Serine/threonine-protein kinase WNK3 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 5YT3C 2.9 Inactive DFGin‑BLBplus out-none none-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 40 - 382 0 None S218D,S222D,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 6V2WB 3.12 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP ATPlike 40 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3SLSA 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nooo ANP, 77D ATPlike, Type3 45 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3SLSB 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nooo ANP, 77D ATPlike, Type3 45 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7B3MA 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnno ANP, SU5 ATPlike, Type3 37 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7B3MB 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_nnno ANP, SU5 ATPlike, Type3 37 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7B7RA 1.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnno ANP, T1K ATPlike, Type3 37 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7B7RB 1.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoo APEdist_nnnn ANP, T1K ATPlike, Type3 39 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7B94A 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_nnno ANP, T3W ATPlike, Type3 37 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7B94B 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoo APEdist_nnnn ANP, T3W ATPlike, Type3 41 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7B9LA 1.7 Inactive DFGin‑BLBplus out-out out-none nonTYR APEdihe_aannn APEdist_nnnn ANP, T4N ATPlike, Type3 37 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7B9LB 1.7 Inactive DFGin‑BLBplus out-out out-none nonTYR APEdihe_aannn APEdist_nnnn ANP, T4N ATPlike, Type3 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3ORNA 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 3OR ATPlike, Type3 62 - 380 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3WIGA 2.7 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, CHU ATPlike, Type3 62 - 380 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 4U80A 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_nnoo ANP, 3EX ATPlike, Type3 62 - 379 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 4LMNA 2.8 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, EUI ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7UMBC 3.231 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, U9F ATPlike, Type3 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 6PP9B 2.59 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, LCJ ATPlike, Type3 38 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7M0VB 3.16 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, EUI ATPlike, Type3 42 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7M0WB 3.09 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, QOA ATPlike, Type3 42 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7M0XB 2.47 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 4BM ATPlike, Type3 40 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7M0YB 3.45 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, QOM ATPlike, Type3 43 - 382 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7M0ZB 3.12 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, CHU ATPlike, Type3 42 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9AXHA 2.81 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 39 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9AXHB 2.81 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 38 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9AXMA 2.42 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 38 - 382 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9AXXA 2.07 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 41 - 382 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9AXXC 2.07 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 37 - 378 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9AYAB 2.59 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 42 - 382 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9AYAD 2.59 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnno A1AHE, ANP Type1, ATPlike 39 - 382 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9AY7B 2.41 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type1, ATPlike 33 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9O0UH 2.91 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo CHU, ANP Type1, ATPlike 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9O0VB 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU, ANP Type1, ATPlike 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9O0VH 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo CHU, ANP Type1, ATPlike 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 4U7ZA 2.805 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_onoo 3EW, ANP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 4U81A 2.701 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_nnoo 3EY, ANP Type3, ATPlike 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9ECUB 3.46 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo A1BIS, ANP Type3, ATPlike 43 - 383 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9AXYB 3.6 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo A1AHE, ANP Type3, ATPlike 40 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9O0VD 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU, ANP Type3, ATPlike 31 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 9O0VF 3.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo CHU, ANP Type3, ATPlike 30 - 380 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7M0TB 3.19 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo 3EW, ANP Type3, ATPlike 42 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7M0UB 3.09 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo QO7, ANP Type3, ATPlike 43 - 385 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 5YT3B 2.9 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaoio APEdist_oooo ANP ATPlike 40 - 382 0 None S218D,S222D,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 5YT3D 2.9 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP ATPlike 39 - 382 0 None S218D,S222D,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 5YT3A 2.9 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanno APEdist_nnnn ANP ATPlike 39 - 382 0 None S218D,S222D,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7F2XA 2.007 Inactive None‑None out-out out-out nonTYR APEdihe_aaiio APEdist_oooo ANP ATPlike 45 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K4 MP2K4_HUMAN 3ALNA 2.3 Inactive DFGin‑BLBplus out-na out-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 83 - 389 0 None None Dual specificity mitogen-activated protein kinase kinase 4 Homo sapiens
STE MAP2K4 MP2K4_HUMAN 3ALNB 2.3 Inactive DFGin‑BLBplus out-na out-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 84 - 390 0 None None Dual specificity mitogen-activated protein kinase kinase 4 Homo sapiens
STE MAP2K4 MP2K4_HUMAN 3ALOA 2.6 Inactive DFGin‑BLBplus out-na out-out nonTYR APEdihe_aaoao APEdist_oooo ANP ATPlike 95 - 389 0 None None Dual specificity mitogen-activated protein kinase kinase 4 Homo sapiens
STE MAP2K4 MP2K4_HUMAN 3ALNC 2.3 Inactive None‑None none-na none-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 100 - 390 0 None None Dual specificity mitogen-activated protein kinase kinase 4 Homo sapiens
STE MAP4K1 M4K1_HUMAN 6CQDA 2.12 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 2 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 6CQDB 2.12 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 4 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4U40A 2.3 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 17 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE OXSR1 OXSR1_HUMAN 3DAKA 2.25 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo ANP ATPlike 6 - 295 0 None None Serine/threonine-protein kinase OSR1 Homo sapiens
STE OXSR1 OXSR1_HUMAN 3DAKB 2.25 Inactive DFGin‑BLBtrans out-out out-none nonTYR APEdihe_aanii APEdist_nnnn ANP ATPlike 6 - 295 0 None None Serine/threonine-protein kinase OSR1 Homo sapiens
STE OXSR1 OXSR1_HUMAN 3DAKC 2.25 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 7 - 295 0 None None Serine/threonine-protein kinase OSR1 Homo sapiens
STE OXSR1 OXSR1_HUMAN 3DAKD 2.25 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_nooo ANP ATPlike 7 - 295 0 None None Serine/threonine-protein kinase OSR1 Homo sapiens
STE OXSR1 OXSR1_HUMAN 2VWIB 2.15 Inactive DFGin‑BLBtrans out-out out-none nonTYR APEdihe_aanii APEdist_nnnn ANP ATPlike 9 - 292 0 None None Serine/threonine-protein kinase OSR1 Homo sapiens
STE OXSR1 OXSR1_HUMAN 2VWIC 2.15 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo ANP ATPlike 9 - 292 0 None None Serine/threonine-protein kinase OSR1 Homo sapiens
STE OXSR1 OXSR1_HUMAN 2VWID 2.15 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ANP ATPlike 6 - 298 0 None None Serine/threonine-protein kinase OSR1 Homo sapiens
STE OXSR1 OXSR1_HUMAN 2VWIA 2.15 Inactive DFGin‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nnno ANP ATPlike 13 - 292 0 None None Serine/threonine-protein kinase OSR1 Homo sapiens
STE PAK1 PAK1_HUMAN 3Q4ZA 1.887 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 251 - 545 0 None S259I,K299R,D389N,L516I Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK4 PAK4_HUMAN 4FIFA 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 296 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 4FIFB 2.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 297 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 4FIGA 3.01 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 298 - 590 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 4JDIA 1.85 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 300 - 589 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 5UPKB 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 300 - 588 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 4FIEA 3.11 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 49 - 590 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 4FIEB 3.11 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 49 - 590 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 7S46A 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 300 - 589 0 None D440N,S474E Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 7S47A 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 300 - 589 0 None D440N,S474E Serine/threonine-protein kinase PAK 4 Homo sapiens
STE PAK4 PAK4_HUMAN 4FIGB 3.01 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 298 - 590 0 SEP474 None Serine/threonine-protein kinase PAK 4 Homo sapiens
STE STK24 STK24_HUMAN 4QMLA 1.882 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 30 - 310 0 TPO190 None Serine/threonine-protein kinase 24 Homo sapiens
STE STK3 STK3_HUMAN 6AO5A 2.955 Inactive DFGin‑BLAplus out-out none-out nonTYR APEdihe_aaioo APEdist_nooo ANP ATPlike 28 - 488 0 None D146N Serine/threonine-protein kinase 3 Homo sapiens
STE STK3 STK3_HUMAN 4LGDA 3.05 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioo ANP ATPlike 16 - 488 0 None D146N Serine/threonine-protein kinase 3 Homo sapiens
STE STK3 STK3_HUMAN 4LGDB 3.05 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioo ANP ATPlike 10 - 488 0 None D146N Serine/threonine-protein kinase 3 Homo sapiens
STE STK3 STK3_HUMAN 4LGDC 3.05 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioo ANP ATPlike 12 - 490 0 None D146N Serine/threonine-protein kinase 3 Homo sapiens
STE STK3 STK3_HUMAN 4LGDD 3.05 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_iioo ANP ATPlike 11 - 489 0 None D146N Serine/threonine-protein kinase 3 Homo sapiens
STE STRADA STRAA_HUMAN 2WTKB 2.65 Pseudo DFGin‑BLAminus out-none in-out nonTYR APEdihe_aaoai APEdist_iooo ANP ATPlike 61 - 431 0 None None STE20-related kinase adapter protein alpha Homo sapiens
STE STRADA STRAA_HUMAN 2WTKE 2.65 Pseudo DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaoai APEdist_iooo ANP ATPlike 60 - 431 0 None None STE20-related kinase adapter protein alpha Homo sapiens
STE TNIK TNIK_HUMAN 7XZRB 2.26 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 12 - 312 0 TPO181,TPO187 None TRAF2 and NCK-interacting protein kinase Homo sapiens
STE TNIK TNIK_HUMAN 7XZRA 2.26 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP Type1.5_Front 12 - 310 0 TPO181,TPO187 None TRAF2 and NCK-interacting protein kinase Homo sapiens
TKL ACVR1 ACVR1_HUMAN 6UNQA 2.4 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi ANP ATPlike 206 - 496 0 None K493A Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 6UNRA 2.2 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi ANP ATPlike 208 - 496 0 None None Activin receptor type-1 Homo sapiens
TKL ARAF ARAF_HUMAN 9AXMB 2.42 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaioi APEdist_nnni ANP ATPlike 302 - 574 0 None Y301D,Y302D Serine/threonine-protein kinase A-Raf Homo sapiens
TKL BRAF BRAF_HUMAN 9AXXB 2.07 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 449 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 9AXYA 3.6 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 448 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 6PP9A 2.59 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 447 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 6V2WA 3.12 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 447 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 7M0TA 3.19 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioo APEdist_iooo ANP ATPlike 448 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 7M0UA 3.09 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 449 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 7M0VA 3.16 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_iooo ANP ATPlike 449 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 7M0WA 3.09 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 448 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 7M0XA 2.47 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 447 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 7M0YA 3.45 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 447 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 7M0ZA 3.12 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_iooo ANP ATPlike 449 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 9ECUA 3.46 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ANP ATPlike 447 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL IRAK4 IRAK4_HUMAN 2OIDA 2.3 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 164 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 2OIDB 2.3 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 2OIDC 2.3 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 166 - 458 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 2OIDD 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 6EGFB 2.61 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn ANP ATPlike 164 - 460 0 None None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL KSR1 KSR1_HUMAN 9AXHC 2.81 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ANP ATPlike 614 - 881 0 None None Kinase suppressor of Ras 1 Homo sapiens
TKL KSR1 KSR1_HUMAN 9AXHD 2.81 Pseudo DFGin‑BLBplus out-none none-out nonTYR APEdihe_aaoai APEdist_oooo ANP ATPlike 613 - 881 0 None None Kinase suppressor of Ras 1 Homo sapiens
TKL KSR1 KSR1_HUMAN 7JUWB 2.88 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ANP ATPlike 601 - 881 0 None None Kinase suppressor of Ras 1 Homo sapiens
TKL KSR1 KSR1_HUMAN 7JUXA 3.34 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ANP ATPlike 600 - 881 0 None None Kinase suppressor of Ras 1 Homo sapiens
TKL KSR1 KSR1_HUMAN 7JUYB 3.096 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ANP ATPlike 601 - 881 0 None None Kinase suppressor of Ras 1 Homo sapiens
TKL KSR1 KSR1_HUMAN 7JUZA 3.21 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ANP ATPlike 601 - 881 0 None None Kinase suppressor of Ras 1 Homo sapiens
TKL KSR1 KSR1_HUMAN 7JV0A 3.63 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ANP ATPlike 601 - 881 0 None None Kinase suppressor of Ras 1 Homo sapiens
TKL KSR1 KSR1_HUMAN 7JV1D 3.62 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ANP ATPlike 600 - 881 0 None None Kinase suppressor of Ras 1 Homo sapiens
TKL KSR2 KSR2_HUMAN 7JURB 2.82 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ANP ATPlike 652 - 932 0 None None Kinase suppressor of Ras 2 Homo sapiens
TKL KSR2 KSR2_HUMAN 7JUSB 2.99 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ANP ATPlike 652 - 932 0 None None Kinase suppressor of Ras 2 Homo sapiens
TKL KSR2 KSR2_HUMAN 7JUTB 3.09 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ANP ATPlike 652 - 932 0 None None Kinase suppressor of Ras 2 Homo sapiens
TKL KSR2 KSR2_HUMAN 7JUUB 3.19 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ANP ATPlike 652 - 932 0 None None Kinase suppressor of Ras 2 Homo sapiens
TKL KSR2 KSR2_HUMAN 7JUVB 3.36 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ANP ATPlike 652 - 932 0 None None Kinase suppressor of Ras 2 Homo sapiens
TKL KSR2 KSR2_HUMAN 7UMBB 3.231 Pseudo DFGin‑BLBplus out-none out-out nonTYR APEdihe_aaoai APEdist_oooo ANP ATPlike 652 - 932 0 None None Kinase suppressor of Ras 2 Homo sapiens
TKL LIMK1 LIMK1_HUMAN 5HVJA 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiai APEdist_oiio ANP ATPlike 329 - 633 0 None D460N LIM domain kinase 1 Homo sapiens
TKL LIMK1 LIMK1_HUMAN 5HVKA 3.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiai APEdist_iiii ANP ATPlike 329 - 634 0 TPO508 D460N LIM domain kinase 1 Homo sapiens
TKL LIMK1 LIMK1_HUMAN 5HVKC 3.5 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiai APEdist_iiii ANP ATPlike 329 - 633 0 TPO508 D460N LIM domain kinase 1 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 8VH5A 4.0 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioi ANP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 8VH5C 4.0 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioi ANP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 8VH4A 4.1 Inactive None‑None out-none out-out nonTYR APEdihe_aaioi APEdist_iioi ANP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL RAF1 RAF1_HUMAN 9AY7A 2.41 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ANP ATPlike 343 - 612 0 None Y340D,Y341D RAF proto-oncogene serine/threonine-protein kinase Homo sapiens
TKL TGFBR2 TGFR2_HUMAN 5E92A 2.08 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 240 - 543 0 None E431A,R433A,E485A,K488A,R493A,R495A TGF-beta receptor type-2 Homo sapiens
TYR EGFR EGFR_HUMAN 3VJNA 2.34 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 697 - 1018 0 None G719S,T790M Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8DSWA 2.39 None DFGin‑BLAminus none-none in-none TYR APEdihe_nniai APEdist_aaai ANP ATPlike 696 - 1017 0 None None Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 2ITXA 2.98 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 697 - 1019 0 None None Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 3VJOA 2.64 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 696 - 1018 0 None None Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 2ITNA 2.47 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai ANP ATPlike 696 - 1019 0 None G719S Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 2ITVA 2.47 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai ANP ATPlike 696 - 1019 0 None L858R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 2EB3A 2.84 Inactive DFGin‑BLAplus in-in in-none TYR APEdihe_nniai APEdist_aaai ANP ATPlike 696 - 1018 0 None None Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 6P1LB 2.8 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao ANP ATPlike 702 - 1008 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 6WAKA 2.4 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaai ANP ATPlike 702 - 1013 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 6WAKD 2.4 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao ANP ATPlike 701 - 1014 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8FV3A 2.1 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 701 - 1014 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8FV4C 2.2 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao ANP ATPlike 702 - 1013 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8TO3B 2.49 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao ANP ATPlike 702 - 1014 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8TO4B 2.99 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nniai APEdist_aaai ANP ATPlike 702 - 1014 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 4ZSED 1.97 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai ANP ATPlike 701 - 1015 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 5D41B 2.31 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_niiai APEdist_aaao ANP ATPlike 701 - 1014 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 5X2AD 1.85 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_niiai APEdist_aaao ANP ATPlike 701 - 1014 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7JXKB 3.1 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nniai APEdist_aaai ANP ATPlike 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7JXMC 2.192 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai ANP ATPlike 702 - 1006 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 5CNOB 1.55 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_niiai APEdist_aaao ANP ATPlike 698 - 1015 0 None V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 5CNNA 1.9 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 699 - 1014 0 None I706Q Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 6P1DB 2.4 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao ANP, NQ1 ATPlike, Type3 702 - 1013 0 None None Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 6P1LA 2.8 Inactive DFGin‑BLBplus out-out none-out TYR APEdihe_nniai APEdist_aaao ANP, 9LL ATPlike, Type3 701 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 6P1LC 2.8 Inactive DFGin‑BLBplus out-out none-out TYR APEdihe_nniai APEdist_aaao ANP, 9LL ATPlike, Type3 702 - 1005 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 6P1LD 2.8 Inactive DFGin‑BLBplus out-out none-out TYR APEdihe_nniai APEdist_aaao ANP, 9LL ATPlike, Type3 702 - 1015 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 6P8QA 1.9 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai ANP, O57 ATPlike, Type3 699 - 1019 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 6XL4D 2.06 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai ANP, NQ1 ATPlike, Type3 700 - 1013 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8TO4C 2.99 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nniai APEdist_aaai ANP, IXR ATPlike, Type3 702 - 1013 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8TO4D 2.99 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nniai APEdist_aaai ANP, IXR ATPlike, Type3 702 - 1005 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 5D41A 2.31 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nniai APEdist_aaai ANP, 57N ATPlike, Type3 698 - 1014 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 6DUKA 2.2 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaai ANP, JBJ ATPlike, Type3 701 - 1006 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 6DUKB 2.2 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai ANP, JBJ ATPlike, Type3 699 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 6DUKC 2.2 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai ANP, JBJ ATPlike, Type3 699 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 6DUKD 2.2 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaai ANP, JBJ ATPlike, Type3 701 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 6DUKE 2.2 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_niiai APEdist_aaai ANP, JBJ ATPlike, Type3 698 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 6DUKF 2.2 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai ANP, JBJ ATPlike, Type3 701 - 1009 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7JXKD 3.1 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai ANP, JBJ ATPlike, Type3 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7JXMD 2.192 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nniai APEdist_aaai ANP, 9LL ATPlike, Type3 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7JXPA 2.16 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaai ANP, JBJ ATPlike, Type3 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7JXPB 2.16 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaai ANP, JBJ ATPlike, Type3 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7JXPD 2.16 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai ANP, JBJ ATPlike, Type3 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7JXPF 2.16 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai ANP, JBJ ATPlike, Type3 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7JXQB 1.83 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_niiai APEdist_aaai ANP, VNS ATPlike, Type3 701 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7JXQD 1.83 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai ANP, VNS ATPlike, Type3 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7LTXA 2.3 Inactive DFGin‑BLBplus out-out none-out TYR APEdihe_nniai APEdist_aaao ANP, YFA ATPlike, Type3 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7LTXB 2.3 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai ANP, YFA ATPlike, Type3 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7LTXC 2.3 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nniai APEdist_aaai ANP, YFA ATPlike, Type3 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7LTXD 2.3 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai ANP, YFA ATPlike, Type3 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8GB4A 2.59 Inactive DFGin‑BLBplus out-out none-out TYR APEdihe_nniai APEdist_aaao ANP, YW5 ATPlike, Type3 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8GB4B 2.59 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan ANP, YW5 ATPlike, Type3 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8GB4C 2.59 Inactive DFGin‑BLBplus out-out none-out TYR APEdihe_nniai APEdist_aaao ANP, YW5 ATPlike, Type3 700 - 1012 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8GB4D 2.59 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan ANP, YW5 ATPlike, Type3 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7K1IA 3.202 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nniai APEdist_aaai ANP, VNS ATPlike, Type3 700 - 1007 0 None L858R,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 6P1DC 2.4 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai NQ1, ANP Type3, ATPlike 702 - 1006 0 None None Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 6P1DD 2.4 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai NQ1, ANP Type3, ATPlike 701 - 1008 0 None None Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7JXQA 1.83 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_niiai APEdist_aaao VNS, ANP Type3, ATPlike 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7JXQC 1.83 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai VNS, ANP Type3, ATPlike 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 6P1DA 2.4 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 700 - 1021 0 None None Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 6WAKB 2.4 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 701 - 1020 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 6WXNB 1.76 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 701 - 1021 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8FV3B 2.1 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 701 - 1021 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8FV3D 2.1 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 701 - 1008 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8FV4A 2.2 Inactive DFGin‑BLBtrans out-out out-out TYR APEdihe_nniai APEdist_aaao ANP ATPlike 701 - 1013 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8TO3C 2.49 Inactive DFGin‑BLBtrans out-out out-out TYR APEdihe_nniai APEdist_aaao ANP ATPlike 702 - 1014 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8TO3D 2.49 Inactive DFGin‑BLBtrans out-out out-out TYR APEdihe_nniai APEdist_aaao ANP ATPlike 702 - 1008 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 8TO4A 2.99 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_nniai APEdist_aaai ANP ATPlike 701 - 1021 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 4ZSEA 1.97 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 699 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 4ZSEB 1.97 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 698 - 1022 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 4ZSEC 1.97 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_nniai APEdist_aaai ANP ATPlike 700 - 1013 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 7JXMA 2.192 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_nniai APEdist_aaai ANP ATPlike 700 - 1007 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 2GS7A 2.6 Inactive DFGin‑BLBtrans out-out out-out TYR APEdihe_niiai APEdist_aaao ANP ATPlike 703 - 1012 0 None V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 2GS7B 2.6 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 701 - 1016 0 None V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 3GT8A 2.955 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 700 - 1014 0 None V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 3GT8B 2.955 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 701 - 1007 0 None V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 3GT8C 2.955 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_nniai APEdist_aaai ANP ATPlike 699 - 1007 0 None V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 3GT8D 2.955 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 701 - 1010 0 None V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 5CNOA 1.55 Inactive DFGin‑BLBtrans out-out out-out TYR APEdihe_niiai APEdist_aaao ANP ATPlike 700 - 1015 0 None V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 5CNNB 1.9 Inactive DFGin‑BLBtrans out-out out-out TYR APEdihe_niiai APEdist_aaao ANP ATPlike 700 - 1014 0 None I706Q Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 5X2AB 1.85 Inactive DFGin‑BLBtrans out-out out-out TYR APEdihe_oiiai APEdist_aaai 7XO, ANP Type1, ATPlike 700 - 1022 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 5X2AA 1.85 Inactive DFGin‑BLBtrans out-out out-none TYR APEdihe_nniai APEdist_aaai 7XO, ANP Type1, Allosteric 700 - 1011 0 None T790M,V948R Epidermal growth factor receptor Homo sapiens
TYR EPHA2 EPHA2_HUMAN 1MQBA 2.3 Inactive DFGin‑BLAminus in-out none-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 605 - 887 0 None None Ephrin type-A receptor 2 Homo sapiens
TYR EPHA2 EPHA2_HUMAN 1MQBB 2.3 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 602 - 883 0 None None Ephrin type-A receptor 2 Homo sapiens
TYR EPHA2 EPHA2_HUMAN 5I9WA 1.359 Inactive DFGin‑BLBminus in-in none-none TYR APEdihe_nniai APEdist_aaai ANP ATPlike 605 - 895 0 None None Ephrin type-A receptor 2 Homo sapiens
TYR EPHA3 EPHA3_HUMAN 2QOCA 1.25 Inactive DFGin‑BLAminus in-out in-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 613 - 906 0 None None Ephrin type-A receptor 3 Homo sapiens
TYR EPHA3 EPHA3_HUMAN 3FXXA 1.7 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 606 - 904 0 None A608T Ephrin type-A receptor 3 Homo sapiens
TYR EPHA3 EPHA3_HUMAN 2QO7A 1.605 Inactive DFGin‑BLAminus in-out none-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 595 - 904 0 PTR701 None Ephrin type-A receptor 3 Homo sapiens
TYR EPHA3 EPHA3_HUMAN 2QO9A 1.55 Inactive DFGin‑BLAminus in-out in-out TYR APEdihe_noiai APEdist_aaai ANP ATPlike 608 - 904 0 None None Ephrin type-A receptor 3 Homo sapiens
TYR EPHA3 EPHA3_HUMAN 2QOQA 1.6 None DFGin‑BLAminus in-in none-none TYR APEdihe_niiai APEdist_aaai ANP ATPlike 595 - 906 0 PTR701 None Ephrin type-A receptor 3 Homo sapiens
TYR ERBB3 ERBB3_HUMAN 3KEXA 2.797 Pseudo DFGin‑BLBplus out-na out-out TYR APEdihe_nnoai APEdist_aaao ANP ATPlike 698 - 994 0 None None Receptor tyrosine-protein kinase erbB-3 Homo sapiens
TYR ERBB3 ERBB3_HUMAN 3KEXB 2.797 Pseudo DFGin‑BLBplus out-na out-out TYR APEdihe_nnoai APEdist_aaao ANP ATPlike 698 - 988 0 None None Receptor tyrosine-protein kinase erbB-3 Homo sapiens
TYR ERBB3 ERBB3_HUMAN 4RIWA 3.1 Pseudo DFGin‑BLBplus out-na out-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 699 - 979 0 None None Receptor tyrosine-protein kinase erbB-3 Homo sapiens
TYR ERBB3 ERBB3_HUMAN 4RIWC 3.1 Pseudo DFGin‑BLBplus out-na out-out TYR APEdihe_oioai APEdist_aaao ANP ATPlike 699 - 979 0 None None Receptor tyrosine-protein kinase erbB-3 Homo sapiens
TYR ERBB3 ERBB3_HUMAN 3LMGA 2.8 Pseudo DFGin‑BLBplus out-na out-out TYR APEdihe_nnoai APEdist_aaao ANP ATPlike 699 - 978 0 None None Receptor tyrosine-protein kinase erbB-3 Homo sapiens
TYR ERBB3 ERBB3_HUMAN 3LMGB 2.8 Pseudo DFGin‑BLBplus out-na out-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 699 - 978 0 None None Receptor tyrosine-protein kinase erbB-3 Homo sapiens
TYR ERBB3 ERBB3_HUMAN 4RIYA 2.981 Pseudo DFGin‑BLBplus out-na out-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 699 - 979 0 None E928G Receptor tyrosine-protein kinase erbB-3 Homo sapiens
TYR ERBB3 ERBB3_HUMAN 4RIYC 2.981 Pseudo DFGin‑BLBplus out-na out-out TYR APEdihe_oioai APEdist_aaao ANP ATPlike 699 - 979 0 None E928G Receptor tyrosine-protein kinase erbB-3 Homo sapiens
TYR ERBB3 ERBB3_HUMAN 4RIXA 3.1 Pseudo DFGin‑BLBplus out-na out-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 699 - 979 0 None Q809R Receptor tyrosine-protein kinase erbB-3 Homo sapiens
TYR ERBB3 ERBB3_HUMAN 4RIXC 3.1 Pseudo DFGin‑BLBplus out-na out-out TYR APEdihe_oioai APEdist_aaao ANP ATPlike 699 - 979 0 None Q809R Receptor tyrosine-protein kinase erbB-3 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 5UGLA 1.861 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ANP ATPlike 468 - 764 0 None D650V Fibroblast growth factor receptor 2 Homo sapiens
TYR FGFR2 FGFR2_HUMAN 5UGLB 1.861 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai ANP ATPlike 467 - 764 0 None D650V Fibroblast growth factor receptor 2 Homo sapiens
TYR HCK HCK_HUMAN 1AD5A 2.6 Inactive DFGin‑BLAminus out-out out-out TYR APEdihe_iioai APEdist_aaao ANP ATPlike 79 - 526 0 PTR522 None Tyrosine-protein kinase HCK Homo sapiens
TYR HCK HCK_HUMAN 1AD5B 2.6 Inactive DFGin‑BLAminus out-out out-out TYR APEdihe_iioai APEdist_aaao ANP ATPlike 79 - 526 0 PTR522 None Tyrosine-protein kinase HCK Homo sapiens
TYR IGF1R IGF1R_HUMAN 1JQHA 2.1 Inactive DFGin‑None in-out none-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 984 - 1286 0 None E979G,Y980S Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 1JQHB 2.1 Inactive DFGin‑None in-out none-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 984 - 1286 0 None E979G,Y980S Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 1JQHC 2.1 Inactive DFGin‑None in-out none-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 984 - 1286 0 None E979G,Y980S Insulin-like growth factor 1 receptor Homo sapiens
TYR INSR INSR_HUMAN 1IR3A 1.9 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 1008 - 1310 0 PTR1185,PTR1189,PTR1190 C1008S,Y1011F Insulin receptor Homo sapiens
TYR LCK LCK_HUMAN 1QPCA 1.6 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 231 - 502 0 PTR394 None Tyrosine-protein kinase Lck Homo sapiens
TYR MERTK MERTK_HUMAN 2P0CA 2.4 Inactive DFGin‑BLBplus out-none none-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 575 - 861 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 2P0CB 2.4 Inactive DFGin‑BLBplus out-none none-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 575 - 861 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MST1R RON_HUMAN 3PLSA 2.24 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oioai APEdist_aaao ANP ATPlike 1060 - 1357 0 None M1254T Macrophage-stimulating protein receptor Homo sapiens
TYR MST1R RON_HUMAN 8ZKDA 2.05 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_iooai APEdist_aaao ANP ATPlike 1060 - 1357 0 None None Macrophage-stimulating protein receptor Homo sapiens
TYR SRC SRC_HUMAN 2SRCA 1.5 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao ANP ATPlike 87 - 536 0 PTR530 None Proto-oncogene tyrosine-protein kinase Src Homo sapiens
TYR SYK KSYK_HUMAN 4FL1A 1.79 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
TYR SYK KSYK_HUMAN 4FL3A 1.9 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 9 - 635 0 None Y348F,Y352F Tyrosine-protein kinase SYK Homo sapiens
TYR SYK KSYK_HUMAN 4FL2A 2.19 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_iioai APEdist_aaao ANP ATPlike 9 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
TYR ZAP70 ZAP70_HUMAN 2OZOA 2.6 Inactive DFGin‑BLAplus out-out out-out TYR APEdihe_nnnao APEdist_aaan ANP ATPlike 2 - 606 0 None Y315F,Y319F,D461N Tyrosine-protein kinase ZAP-70 Homo sapiens
TYR ZAP70 ZAP70_HUMAN 4K2RA 3.0 Inactive DFGin‑BLAplus out-out none-out TYR APEdihe_nnoai APEdist_aaao ANP ATPlike 2 - 606 0 None D461N Tyrosine-protein kinase ZAP-70 Homo sapiens
OTHER LPL0262 Q5WZW9_LEGPL 5CKWA 2.49 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 15 - 404 0 None None non-specific serine/threonine protein kinase Legionella pneumophila
OTHER LPL0262 Q5WZW9_LEGPL 5CKWB 2.49 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 1 - 404 0 None None non-specific serine/threonine protein kinase Legionella pneumophila
CMGC MAPK A0A3Q8ITZ9_LEIDO 4QNYA 2.257 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiai APEdist_oooo ANP ATPlike 4 - 350 0 None None Mitogen activated protein kinase, putative Leishmania donovani
CMGC MAPK A0A3Q8ITZ9_LEIDO 4QNYB 2.257 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiai APEdist_oooo ANP ATPlike 4 - 350 0 None None Mitogen activated protein kinase, putative Leishmania donovani
TKL LYK3 LYK3_MEDTR 9GFZA 2.5 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaiii APEdist_oioi ANP ATPlike 302 - 596 0 None D459N LysM domain receptor-like kinase 3 Medicago truncatula
TKL LYR4 G7K7K0_MEDTR 8PS7B 2.1 Pseudo DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaooi APEdist_iioo ANP ATPlike 340 - 636 0 None None LysM-domain receptor-like kinase Medicago truncatula
TKL LYR4 G7K7K0_MEDTR 8PS7A 2.1 Pseudo DFGin‑None out-out out-out nonTYR APEdihe_aaoii APEdist_oooo ANP ATPlike 340 - 636 0 None None LysM-domain receptor-like kinase Medicago truncatula
OTHER BUD32 KAE1B_METJA 2VWBA 3.05 Inactive DFGin‑None in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP Allosteric 1 - 530 0 None None Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein Methanocaldococcus jannaschii
OTHER BUD32 KAE1B_METJA 2VWBB 3.05 Inactive DFGin‑None in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP Allosteric 1 - 532 0 None None Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein Methanocaldococcus jannaschii
OTHER STT7 C1EBN1_MICCC 4IX5A 1.7 Inactive None‑None none-na in-none nonTYR APEdihe_aannn APEdist_nnnn ANP none 151 - 489 0 None None Protein kinase domain-containing protein Micromonas commoda
OTHER STT7 C1EBN1_MICCC 4IX5B 1.7 Inactive None‑None none-na in-none nonTYR APEdihe_aannn APEdist_nnnn ANP none 151 - 489 0 None None Protein kinase domain-containing protein Micromonas commoda
AGC PRKACA KAPCA_MOUSE 6MM6C 2.39 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 19 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 6MM6E 2.39 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 19 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 6MM7A 1.85 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 17 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 6MM7D 1.85 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 16 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 6MM8C 1.85 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 16 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 8UKND 2.75 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 16 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 8UKOE 2.89 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 16 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 8UKPE 2.85 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 17 - 351 0 SEP140,TPO198 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 7E11A 3.43 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 14 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 6MM5E 1.95 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 16 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 3PVBA 3.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 7 - 351 0 SEP11,SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 2QCSA 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 14 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 3IDBA 1.62 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 9 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 3IDCA 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 9 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4DG0E 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 11 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4DH7A 1.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 16 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4DH8A 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 16 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4HPTE 2.15 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 15 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4HPUE 1.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 13 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4DFXE 1.35 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 2 - 351 0 SEP140,TPO198,SEP339 K8C cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4XW4A 1.82 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 15 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 7E0ZA 2.162 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 14 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 7E12A 2.796 Inactive DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 19 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4DG3E 1.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 15 - 351 0 SEP140,TPO198 R337A cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 3O7LB 2.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 18 - 351 0 TPO198 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 3FHIA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 14 - 351 0 TPO198,SEP339 C200A cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC RPS6KA3-1 KS6A3_MOUSE 3G51A 1.8 Inactive DFGin‑None none-none out-none nonTYR APEdihe_aanii APEdist_nnnn ANP ATPlike 47 - 346 0 None None Ribosomal protein S6 kinase alpha-3 Mus musculus
CAMK CAMK2A KCC2A_MOUSE 7B56B 1.45 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 5 - 307 0 None T305A,T306A Calcium/calmodulin-dependent protein kinase type II subunit alpha Mus musculus
CAMK MELK MELK_MOUSE 4BFMA 2.35 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnii ANP ATPlike 2 - 326 0 None T167E Maternal embryonic leucine zipper kinase Mus musculus
OTHER POMK SG196_MOUSE 5GZ9A 2.4 Pseudo DFGin‑ABAminus none-na in-out nonTYR APEdihe_aaiao APEdist_iioo ANP, MAN ATPlike, Allosteric 54 - 337 0 None N66Q,N164Q Protein O-mannose kinase Mus musculus
STE STK39 STK39_MOUSE 5DBXA 2.5 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nooo ANP ATPlike 65 - 365 0 None T243D STE20/SPS1-related proline-alanine-rich protein kinase Mus musculus
STE STK39 STK39_MOUSE 5DBXB 2.5 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nooo ANP ATPlike 65 - 364 0 None T243D STE20/SPS1-related proline-alanine-rich protein kinase Mus musculus
TKL RIPK3 RIPK3_MOUSE 4M69A 2.497 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooi APEdist_oooo ANP ATPlike 12 - 312 0 SEP184,TPO231,SEP232 None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
TYR EPHB2 EPHB2_MOUSE 1JPAA 1.91 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 594 - 892 0 None Y596F,Y602F Ephrin type-B receptor 2 Mus musculus
TYR EPHB2 EPHB2_MOUSE 1JPAB 1.91 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 594 - 891 0 None Y596F,Y602F Ephrin type-B receptor 2 Mus musculus
TYR LYN LYN_MOUSE 2ZV8A 2.7 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 239 - 501 0 None None Tyrosine-protein kinase Lyn Mus musculus
OTHER PAN3 PAN3_NEUCR 4CZYB 3.4 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ANP ATPlike 234 - 645 0 None None PAN2-PAN3 deadenylation complex subunit pan3 Neurospora crassa
OTHER PAN3 PAN3_NEUCR 4CZYD 3.4 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ANP ATPlike 234 - 645 0 None None PAN2-PAN3 deadenylation complex subunit pan3 Neurospora crassa
STE MAP2K1 MP2K1_RABIT 7JUWC 2.88 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP ATPlike 40 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JURC 2.82 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, QOM ATPlike, Type1 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUTC 3.09 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 3EW ATPlike, Type3 41 - 380 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUUC 3.19 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 4BM ATPlike, Type3 43 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUVC 3.36 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, VKG ATPlike, Type3 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUXC 3.34 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, QOM ATPlike, Type3 40 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUYC 3.096 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, EUI ATPlike, Type3 40 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUZC 3.21 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 3EW ATPlike, Type3 40 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JV0C 3.63 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 4BM ATPlike, Type3 40 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JV1C 3.62 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, VKG ATPlike, Type3 40 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUSC 2.99 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo VKD, ANP Type3, ATPlike 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
OTHER PINK1 PINK1_PEDHC 8UYHA 2.84 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiai APEdist_iiii ANP ATPlike 115 - 574 0 TPO305 None Serine/threonine-protein kinase Pink1, mitochondrial Pediculus humanus
OTHER PINK1 PINK1_PEDHC 8UYHB 2.84 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiai APEdist_iiii ANP ATPlike 121 - 574 0 TPO305 None Serine/threonine-protein kinase Pink1, mitochondrial Pediculus humanus
CAMK CDPK1 CDPK1_PLABA 3Q5IA 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 38 - 518 0 None None Calcium-dependent protein kinase 1 Plasmodium berghei
CMGC MAPK Q7KQK7_PLAF7 3NIEA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oioo ANP ATPlike 95 - 499 0 None None Mitogen-activated protein kinase Plasmodium falciparum
CMGC MAPK Q7KQK7_PLAF7 3NIEB 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oioo ANP ATPlike 95 - 505 0 None None Mitogen-activated protein kinase Plasmodium falciparum
CMGC PSTK1 Q8IL19_PLAF7 3LLTA 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 535 - 875 0 None None Protein serine/threonine kinase-1 Plasmodium falciparum
OTHER PK7 O96214_PLAFA 2PMLX 2.6 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 1 - 316 0 None None mitogen-activated protein kinase kinase Plasmodium falciparum
AGC PKG KGP_PLAVS 5DZCA 2.3 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 1 - 843 0 None None cGMP-dependent protein kinase Plasmodium vivax
AGC PRKCB KPCB_RAT 3PFQA 4.0 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 101 - 668 0 TPO500,TPO642,SEP661 C71S,C217S,R622S Protein kinase C beta type Rattus norvegicus
CMGC MAPK1 MK01_RAT 4S33A 1.48 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii ANP ATPlike 4 - 355 0 None R65S Mitogen-activated protein kinase 1 Rattus norvegicus
CMGC MAPK1 MK01_RAT 4S32A 1.34 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_oiii ANP ATPlike 4 - 354 0 None None Mitogen-activated protein kinase 1 Rattus norvegicus
CMGC MAPK1 MK01_RAT 7UGBA 1.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ANP ATPlike 9 - 354 0 None None Mitogen-activated protein kinase 1 Rattus norvegicus
CMGC MAPK1 MK01_RAT 4S34A 2.5 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_oiii ANP ATPlike 4 - 354 0 None I84A Mitogen-activated protein kinase 1 Rattus norvegicus
CMGC MAPK1 MK01_RAT 8RQVA 2.19 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaini APEdist_oiii ANP ATPlike 4 - 354 0 None T188A Mitogen-activated protein kinase 1 Rattus norvegicus
CMGC MAPK1 MK01_RAT 8RQXA 1.7 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiai APEdist_oiii ANP ATPlike 4 - 353 0 None R65S,T188D Mitogen-activated protein kinase 1 Rattus norvegicus
CMGC MAPK1 MK01_RAT 8RQWA 1.8 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiai APEdist_oiii ANP ATPlike 4 - 354 0 None T188E Mitogen-activated protein kinase 1 Rattus norvegicus
OTHER WNK1 WNK1_RAT 5W7TA 2.01 Inactive DFGin‑BLBtrans out-na out-out nonTYR APEdihe_aaiii APEdist_oioi ANP ATPlike 210 - 482 0 SEP382 None Serine/threonine-protein kinase WNK1 Rattus norvegicus
OTHER WNK1 WNK1_RAT 5W7TB 2.01 Inactive DFGin‑BLBtrans out-na out-out nonTYR APEdihe_aaiii APEdist_oiii ANP ATPlike 210 - 482 0 SEP382 None Serine/threonine-protein kinase WNK1 Rattus norvegicus
AGC CBK1 CBK1_YEAST 4LQSA 3.3 Inactive None‑None none-none out-out nonTYR APEdihe_aaioo APEdist_oooo ANP ATPlike 294 - 749 0 None D475A Serine/threonine-protein kinase CBK1 Saccharomyces cerevisiae
AGC CBK1 CBK1_YEAST 5NCLA 3.15 Inactive None‑None none-none out-out nonTYR APEdihe_aaioo APEdist_oooo ANP ATPlike 266 - 756 0 None D475A Serine/threonine-protein kinase CBK1 Saccharomyces cerevisiae
AGC CBK1 CBK1_YEAST 4LQPA 4.5 Inactive None‑None none-none out-out nonTYR APEdihe_aaioo APEdist_oooo ANP ATPlike 282 - 749 0 None D475A,T743E Serine/threonine-protein kinase CBK1 Saccharomyces cerevisiae
AGC CBK1 CBK1_YEAST 4LQQA 3.6 Inactive None‑None none-none out-out nonTYR APEdihe_aaioo APEdist_oooo ANP ATPlike 282 - 749 0 None D475A,T743E Serine/threonine-protein kinase CBK1 Saccharomyces cerevisiae
CAMK RAD53 RAD53_YEAST 4PDSA 2.9 None DFGin‑BLAminus in-none in-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 191 - 490 0 None A225S,D339A Serine/threonine-protein kinase RAD53 Saccharomyces cerevisiae
CAMK RAD53 RAD53_YEAST 4PDSB 2.9 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aanoi APEdist_nnnn ANP ATPlike 191 - 494 0 None A225S,D339A Serine/threonine-protein kinase RAD53 Saccharomyces cerevisiae
CAMK RAD53 RAD53_YEAST 5XZVB 3.1 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaiii APEdist_iooo ANP ATPlike 32 - 466 0 None None Serine/threonine-protein kinase RAD53 Saccharomyces cerevisiae
CAMK RAD53 RAD53_YEAST 5XZVA 3.1 Inactive DFGin‑None in-out out-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 16 - 465 0 None None Serine/threonine-protein kinase RAD53 Saccharomyces cerevisiae
CMGC CKA1 CSK21_YEAST 4JQEA 1.77 Inactive None‑None out-na in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 3 - 371 0 None None Casein kinase II subunit alpha Saccharomyces cerevisiae
CMGC SKY1 SKY1_YEAST 1Q99A 2.11 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 143 - 737 0 None None Serine/threonine-protein kinase SKY1 Saccharomyces cerevisiae
CMGC SKY1 SKY1_YEAST 1Q99B 2.11 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 142 - 737 0 None None Serine/threonine-protein kinase SKY1 Saccharomyces cerevisiae
OTHER BUD32 BUD32_YEAST 4WW5A 1.997 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP Type1.5_Front 5 - 257 0 None None EKC/KEOPS complex subunit BUD32 Saccharomyces cerevisiae
OTHER GCN2-2 GCN2_YEAST 1ZY5A 2.0 Inactive DFGin‑BLBminus out-out out-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 594 - 996 0 None R794G eIF-2-alpha kinase GCN2 Saccharomyces cerevisiae
OTHER GCN2-2 GCN2_YEAST 1ZY5B 2.0 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaooi APEdist_nnno ANP ATPlike 594 - 983 0 None R794G eIF-2-alpha kinase GCN2 Saccharomyces cerevisiae
AGC PRKACA KAPCA_PIG 1CDKA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 9 - 351 0 TPO198 None cAMP-dependent protein kinase catalytic subunit alpha Sus scrofa
AGC PRKACA KAPCA_PIG 1CDKB 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 9 - 351 0 TPO198 None cAMP-dependent protein kinase catalytic subunit alpha Sus scrofa
OTHER RNASEL A5H025_PIG 4O1PA 2.5 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP, 25L ATPlike, Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa
OTHER RNASEL A5H025_PIG 4O1PB 2.5 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP, 25L ATPlike, Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa
OTHER RNASEL A5H025_PIG 4O1PC 2.5 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP, 25L ATPlike, Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa
OTHER RNASEL A5H025_PIG 4O1PD 2.5 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP, 25L ATPlike, Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa
OTHER TCUR0376 D1A2F7_THECD 8CAVA 2.87 Inactive DFGout‑None out-na in-out nonTYR APEdihe_aaiii APEdist_oiii ANP Allosteric 6 - 865 0 None None Serine/threonine protein kinase Thermomonospora curvata
OTHER TCUR0376 D1A2F7_THECD 8CAVB 2.87 Inactive DFGout‑None out-na in-out nonTYR APEdihe_aaiii APEdist_oiii ANP Allosteric 6 - 863 0 None None Serine/threonine protein kinase Thermomonospora curvata
CAMK CDPK1 Q9BJF5_TOXGO 4IEBA 2.05 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 32 - 507 0 None G128M non-specific serine/threonine protein kinase Toxoplasma gondii
CAMK CDPK1 Q9BJF5_TOXGO 3HX4A 1.95 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 30 - 503 0 None None non-specific serine/threonine protein kinase Toxoplasma gondii
CAMK CDPK1 Q9BJF5_TOXGO 3KU2A 2.3 Inactive None‑None out-none out-out nonTYR APEdihe_aaooi APEdist_oooo ANP ATPlike 44 - 507 0 None None non-specific serine/threonine protein kinase Toxoplasma gondii
OTHER ROP18 ROP18_TOXGO 4JRNA 2.71 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_inni ANP Allosteric 187 - 548 0 None None Serine/threonine-protein kinase ROP18 Toxoplasma gondii
OTHER PINK1 PINK1_TRICA 5YJ9D 2.53 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaiao APEdist_iiii ANP ATPlike 166 - 570 0 None S205D,S377D,T386E,T530E Serine/threonine-protein kinase Pink1, mitochondrial Tribolium castaneum
CMGC TVAG125560 A2F9N1_TRIV3 9AV7A 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 15 - 318 0 None None non-specific serine/threonine protein kinase Trichomonas vaginalis
CAMK AURKBA AUKBA_XENLA 4C2WA 1.7 Inactive DFGin‑ABAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 88 - 356 0 TPO248 None Aurora kinase B-A Xenopus laevis
CAMK AURKBA AUKBA_XENLA 4C2WB 1.7 Inactive DFGin‑ABAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 78 - 355 0 TPO248 None Aurora kinase B-A Xenopus laevis
CMGC ACK2 CSK2A_MAIZE 1DAWA 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 2 - 328 0 None None Casein kinase II subunit alpha Zea mays
CMGC ACK2 CSK2A_MAIZE 1LP4A 1.86 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 2 - 328 0 None None Casein kinase II subunit alpha Zea mays
OTHER SIRK1 K7VIQ3_MAIZE 5UV4A 2.3 Pseudo DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaono APEdist_oioo ANP ATPlike 744 - 1045 0 None None Putative leucine-rich repeat protein kinase family protein Zea mays

Ligand: ANP

Total number of chains: 142
Active chains: 40
Total number of genes: 50
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 71 50.0% 4S32A
DFGin ABAminus 18 12.7% 4C2WA
DFGin BLBplus 18 12.7% 7CTXB
DFGin None 13 9.2% 2VWBA
None None 9 6.3% 4IX5A
DFGin BLBminus 6 4.2% 7CTVA
DFGout None 4 2.8% 4I94A
DFGin BLBtrans 3 2.1% 5W7TA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC CKA1 CSK21_ARATH 6XX7A 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 77 - 406 0 None None Casein kinase II subunit alpha-1 Arabidopsis thaliana
CMGC MPK4 MPK4_ARATH 7W5CA 2.201 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_oioo ANP ATPlike 18 - 372 0 None None Mitogen-activated protein kinase 4 Arabidopsis thaliana
OTHER BSK8 BSK8_ARATH 4I94A 1.8 Pseudo DFGout‑None out-out out-out nonTYR APEdihe_aaiai APEdist_iioo ANP ATPlike 40 - 328 0 None None Serine/threonine-protein kinase BSK8 Arabidopsis thaliana
OTHER BSK8 BSK8_ARATH 4I94B 1.8 Pseudo DFGout‑None out-out out-out nonTYR APEdihe_aaiai APEdist_iioo ANP ATPlike 40 - 328 0 None None Serine/threonine-protein kinase BSK8 Arabidopsis thaliana
TKL BAK1 BAK1_ARATH 3UIMA 2.2 Inactive DFGin‑BLAminus in-out in-none nonTYR APEdihe_aaini APEdist_iiii ANP ATPlike 272 - 573 0 SEP290,TPO312,TPO446,TPO449,TPO450,TPO455 None BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1 Arabidopsis thaliana
TKL BRI1 BRI1_ARATH 5LPVA 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 867 - 1160 0 TPO1039,SEP1042,SEP1044 T872A Protein BRASSINOSTEROID INSENSITIVE 1 Arabidopsis thaliana
TKL BRI1 BRI1_ARATH 4OH4A 2.25 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 863 - 1160 0 TPO1039,SEP1042,SEP1044,SEP1060 None Protein BRASSINOSTEROID INSENSITIVE 1 Arabidopsis thaliana
TKL BRI1 BRI1_ARATH 4OH4B 2.25 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 867 - 1160 0 TPO1039,SEP1042,SEP1044,SEP1060 None Protein BRASSINOSTEROID INSENSITIVE 1 Arabidopsis thaliana
TKL BRI1 BRI1_ARATH 4Q5JA 2.772 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 863 - 1160 0 TPO1039,SEP1042,SEP1044,SEP1060 None Protein BRASSINOSTEROID INSENSITIVE 1 Arabidopsis thaliana
TKL BRI1 BRI1_ARATH 4Q5JB 2.772 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 867 - 1160 0 TPO1039,SEP1042,SEP1044,SEP1060 None Protein BRASSINOSTEROID INSENSITIVE 1 Arabidopsis thaliana
TKL CARK1 CARK1_ARATH 5XD6A 1.898 Inactive DFGin‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 50 - 350 0 None None Protein CYTOSOLIC ABA RECEPTOR KINASE 1 Arabidopsis thaliana
TKL CARK1 CARK1_ARATH 5XD6B 1.898 Inactive DFGin‑None out-na none-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 50 - 350 0 None None Protein CYTOSOLIC ABA RECEPTOR KINASE 1 Arabidopsis thaliana
TKL SOBIR1 SBIR1_ARATH 7CTVA 2.886 Inactive DFGin‑BLBminus out-none out-out nonTYR APEdihe_aaooi APEdist_oooo ANP ATPlike 326 - 639 0 None D489A Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1 Arabidopsis thaliana
TKL SOBIR1 SBIR1_ARATH 7CTVB 2.886 Inactive DFGin‑BLBminus out-none out-out nonTYR APEdihe_aaooi APEdist_oooo ANP ATPlike 326 - 640 0 None D489A Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1 Arabidopsis thaliana
TKL SOBIR1 SBIR1_ARATH 7CTXA 2.907 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooi APEdist_oooo ANP ATPlike 326 - 639 0 None None Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1 Arabidopsis thaliana
TKL SOBIR1 SBIR1_ARATH 7CTXB 2.907 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooi APEdist_oooo ANP ATPlike 326 - 640 0 None None Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1 Arabidopsis thaliana
AGC PRKACA KAPCA_BOVIN 9DW5G 3.8 None DFGin‑BLAminus out-none in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 13 - 351 0 TPO198 None cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
AGC PRKACA KAPCA_BOVIN 9DW8G 3.5 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 15 - 329 0 TPO198 None cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
AGC PRKACA KAPCA_BOVIN 9DW7G 6.0 Inactive None‑None out-none in-out nonTYR APEdihe_aaini APEdist_iiio ANP ATPlike 13 - 351 0 None None cAMP-dependent protein kinase catalytic subunit alpha Bos taurus
TYR LET23 LET23_CAEEL 5WNOA 2.386 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nooai APEdist_aaao ANP ATPlike 876 - 1190 0 None None Receptor tyrosine-protein kinase let-23 Caenorhabditis elegans
CMGC CK2 Q5KF69_CRYD1 6ISEA 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 5 - 331 0 None None Casein kinase II subunit alpha Cryptococcus deneoformans
CMGC CK2 Q5KF69_CRYD1 6ISEB 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 5 - 331 0 None None Casein kinase II subunit alpha Cryptococcus deneoformans
CMGC CKA1 J9VNH4_CRYN9 6KO6B 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 5 - 334 0 None None Casein kinase II subunit alpha Cryptococcus neoformans
CAMK CDPK1 A3FQ16_CRYPI 3IGOA 2.25 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn ANP ATPlike 70 - 537 0 None None non-specific serine/threonine protein kinase Cryptosporidium parvum
CAMK CDPK3 Q5CS01_CRYPI 3LIJA 1.9 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 42 - 516 0 None None Calcium-dependent protein kinase 1 Cryptosporidium parvum
CAMK CDPK4-2 Q5CZ29_CRYPI 3HKOA 1.8 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaiii APEdist_nnoi ANP ATPlike 126 - 452 0 None None non-specific serine/threonine protein kinase Cryptosporidium parvum
CMGC BSK JNK_DROME 5AWMA 1.79 Inactive DFGin‑ABAminus out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo ANP ATPlike 7 - 362 0 None None Stress-activated protein kinase JNK Drosophila melanogaster
STE DSOR1 DSOR1_DROME 8BW9C 3.32 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, QOM ATPlike, Type3 81 - 384 0 None None Dual specificity mitogen-activated protein kinase kinase dSOR1 Drosophila melanogaster
TYR PTK2 FAK1_CHICK 2J0LA 2.3 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_iiiai APEdist_aaao ANP ATPlike 411 - 686 0 PTR576,PTR577 None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 6TY4A 5.96 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 34 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
TYR PTK2 FAK1_CHICK 6TY4B 5.96 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 34 - 686 0 None None Focal adhesion kinase 1 Gallus gallus
OTHER LPL0262 Q5WZW9_LEGPL 5CKWA 2.49 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 15 - 404 0 None None non-specific serine/threonine protein kinase Legionella pneumophila
OTHER LPL0262 Q5WZW9_LEGPL 5CKWB 2.49 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 1 - 404 0 None None non-specific serine/threonine protein kinase Legionella pneumophila
CMGC MAPK A0A3Q8ITZ9_LEIDO 4QNYA 2.257 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiai APEdist_oooo ANP ATPlike 4 - 350 0 None None Mitogen activated protein kinase, putative Leishmania donovani
CMGC MAPK A0A3Q8ITZ9_LEIDO 4QNYB 2.257 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiai APEdist_oooo ANP ATPlike 4 - 350 0 None None Mitogen activated protein kinase, putative Leishmania donovani
TKL LYK3 LYK3_MEDTR 9GFZA 2.5 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaiii APEdist_oioi ANP ATPlike 302 - 596 0 None D459N LysM domain receptor-like kinase 3 Medicago truncatula
TKL LYR4 G7K7K0_MEDTR 8PS7B 2.1 Pseudo DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaooi APEdist_iioo ANP ATPlike 340 - 636 0 None None LysM-domain receptor-like kinase Medicago truncatula
TKL LYR4 G7K7K0_MEDTR 8PS7A 2.1 Pseudo DFGin‑None out-out out-out nonTYR APEdihe_aaoii APEdist_oooo ANP ATPlike 340 - 636 0 None None LysM-domain receptor-like kinase Medicago truncatula
OTHER BUD32 KAE1B_METJA 2VWBA 3.05 Inactive DFGin‑None in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP Allosteric 1 - 530 0 None None Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein Methanocaldococcus jannaschii
OTHER BUD32 KAE1B_METJA 2VWBB 3.05 Inactive DFGin‑None in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP Allosteric 1 - 532 0 None None Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein Methanocaldococcus jannaschii
OTHER STT7 C1EBN1_MICCC 4IX5A 1.7 Inactive None‑None none-na in-none nonTYR APEdihe_aannn APEdist_nnnn ANP none 151 - 489 0 None None Protein kinase domain-containing protein Micromonas commoda
OTHER STT7 C1EBN1_MICCC 4IX5B 1.7 Inactive None‑None none-na in-none nonTYR APEdihe_aannn APEdist_nnnn ANP none 151 - 489 0 None None Protein kinase domain-containing protein Micromonas commoda
AGC PRKACA KAPCA_MOUSE 6MM6C 2.39 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 19 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 6MM6E 2.39 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 19 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 6MM7A 1.85 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 17 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 6MM7D 1.85 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 16 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 6MM8C 1.85 Inactive DFGin‑ABAminus out-out in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 16 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 8UKND 2.75 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 16 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 8UKOE 2.89 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 16 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 8UKPE 2.85 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 17 - 351 0 SEP140,TPO198 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 7E11A 3.43 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 14 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 6MM5E 1.95 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 16 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 3PVBA 3.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 7 - 351 0 SEP11,SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 2QCSA 2.2 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 14 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 3IDBA 1.62 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 9 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 3IDCA 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 9 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4DG0E 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 11 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4DH7A 1.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 16 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4DH8A 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 16 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4HPTE 2.15 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 15 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4HPUE 1.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 13 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4DFXE 1.35 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 2 - 351 0 SEP140,TPO198,SEP339 K8C cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4XW4A 1.82 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 15 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 7E0ZA 2.162 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 14 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 7E12A 2.796 Inactive DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 19 - 351 0 TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 4DG3E 1.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 15 - 351 0 SEP140,TPO198 R337A cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 3O7LB 2.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 18 - 351 0 TPO198 None cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC PRKACA KAPCA_MOUSE 3FHIA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 14 - 351 0 TPO198,SEP339 C200A cAMP-dependent protein kinase catalytic subunit alpha Mus musculus
AGC RPS6KA3-1 KS6A3_MOUSE 3G51A 1.8 Inactive DFGin‑None none-none out-none nonTYR APEdihe_aanii APEdist_nnnn ANP ATPlike 47 - 346 0 None None Ribosomal protein S6 kinase alpha-3 Mus musculus
CAMK CAMK2A KCC2A_MOUSE 7B56B 1.45 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 5 - 307 0 None T305A,T306A Calcium/calmodulin-dependent protein kinase type II subunit alpha Mus musculus
CAMK MELK MELK_MOUSE 4BFMA 2.35 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnii ANP ATPlike 2 - 326 0 None T167E Maternal embryonic leucine zipper kinase Mus musculus
OTHER POMK SG196_MOUSE 5GZ9A 2.4 Pseudo DFGin‑ABAminus none-na in-out nonTYR APEdihe_aaiao APEdist_iioo ANP, MAN ATPlike, Allosteric 54 - 337 0 None N66Q,N164Q Protein O-mannose kinase Mus musculus
STE STK39 STK39_MOUSE 5DBXA 2.5 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nooo ANP ATPlike 65 - 365 0 None T243D STE20/SPS1-related proline-alanine-rich protein kinase Mus musculus
STE STK39 STK39_MOUSE 5DBXB 2.5 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nooo ANP ATPlike 65 - 364 0 None T243D STE20/SPS1-related proline-alanine-rich protein kinase Mus musculus
TKL RIPK3 RIPK3_MOUSE 4M69A 2.497 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooi APEdist_oooo ANP ATPlike 12 - 312 0 SEP184,TPO231,SEP232 None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
TYR EPHB2 EPHB2_MOUSE 1JPAA 1.91 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 594 - 892 0 None Y596F,Y602F Ephrin type-B receptor 2 Mus musculus
TYR EPHB2 EPHB2_MOUSE 1JPAB 1.91 Inactive DFGin‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan ANP ATPlike 594 - 891 0 None Y596F,Y602F Ephrin type-B receptor 2 Mus musculus
TYR LYN LYN_MOUSE 2ZV8A 2.7 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 239 - 501 0 None None Tyrosine-protein kinase Lyn Mus musculus
OTHER PAN3 PAN3_NEUCR 4CZYB 3.4 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ANP ATPlike 234 - 645 0 None None PAN2-PAN3 deadenylation complex subunit pan3 Neurospora crassa
OTHER PAN3 PAN3_NEUCR 4CZYD 3.4 Pseudo DFGin‑None out-na out-na noAPE APEdihe_aaaaa APEdist_aaaa ANP ATPlike 234 - 645 0 None None PAN2-PAN3 deadenylation complex subunit pan3 Neurospora crassa
STE MAP2K1 MP2K1_RABIT 7JUWC 2.88 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP ATPlike 40 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JURC 2.82 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, QOM ATPlike, Type1 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUTC 3.09 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 3EW ATPlike, Type3 41 - 380 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUUC 3.19 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 4BM ATPlike, Type3 43 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUVC 3.36 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, VKG ATPlike, Type3 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUXC 3.34 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, QOM ATPlike, Type3 40 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUYC 3.096 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, EUI ATPlike, Type3 40 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUZC 3.21 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 3EW ATPlike, Type3 40 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JV0C 3.63 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 4BM ATPlike, Type3 40 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JV1C 3.62 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, VKG ATPlike, Type3 40 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JUSC 2.99 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo VKD, ANP Type3, ATPlike 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
OTHER PINK1 PINK1_PEDHC 8UYHA 2.84 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiai APEdist_iiii ANP ATPlike 115 - 574 0 TPO305 None Serine/threonine-protein kinase Pink1, mitochondrial Pediculus humanus
OTHER PINK1 PINK1_PEDHC 8UYHB 2.84 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiai APEdist_iiii ANP ATPlike 121 - 574 0 TPO305 None Serine/threonine-protein kinase Pink1, mitochondrial Pediculus humanus
CAMK CDPK1 CDPK1_PLABA 3Q5IA 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 38 - 518 0 None None Calcium-dependent protein kinase 1 Plasmodium berghei
CMGC MAPK Q7KQK7_PLAF7 3NIEA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oioo ANP ATPlike 95 - 499 0 None None Mitogen-activated protein kinase Plasmodium falciparum
CMGC MAPK Q7KQK7_PLAF7 3NIEB 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oioo ANP ATPlike 95 - 505 0 None None Mitogen-activated protein kinase Plasmodium falciparum
CMGC PSTK1 Q8IL19_PLAF7 3LLTA 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 535 - 875 0 None None Protein serine/threonine kinase-1 Plasmodium falciparum
OTHER PK7 O96214_PLAFA 2PMLX 2.6 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 1 - 316 0 None None mitogen-activated protein kinase kinase Plasmodium falciparum
AGC PKG KGP_PLAVS 5DZCA 2.3 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 1 - 843 0 None None cGMP-dependent protein kinase Plasmodium vivax
AGC PRKCB KPCB_RAT 3PFQA 4.0 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 101 - 668 0 TPO500,TPO642,SEP661 C71S,C217S,R622S Protein kinase C beta type Rattus norvegicus
CMGC MAPK1 MK01_RAT 4S33A 1.48 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii ANP ATPlike 4 - 355 0 None R65S Mitogen-activated protein kinase 1 Rattus norvegicus
CMGC MAPK1 MK01_RAT 4S32A 1.34 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_oiii ANP ATPlike 4 - 354 0 None None Mitogen-activated protein kinase 1 Rattus norvegicus
CMGC MAPK1 MK01_RAT 7UGBA 1.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo ANP ATPlike 9 - 354 0 None None Mitogen-activated protein kinase 1 Rattus norvegicus
CMGC MAPK1 MK01_RAT 4S34A 2.5 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_oiii ANP ATPlike 4 - 354 0 None I84A Mitogen-activated protein kinase 1 Rattus norvegicus
CMGC MAPK1 MK01_RAT 8RQVA 2.19 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaini APEdist_oiii ANP ATPlike 4 - 354 0 None T188A Mitogen-activated protein kinase 1 Rattus norvegicus
CMGC MAPK1 MK01_RAT 8RQXA 1.7 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiai APEdist_oiii ANP ATPlike 4 - 353 0 None R65S,T188D Mitogen-activated protein kinase 1 Rattus norvegicus
CMGC MAPK1 MK01_RAT 8RQWA 1.8 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiai APEdist_oiii ANP ATPlike 4 - 354 0 None T188E Mitogen-activated protein kinase 1 Rattus norvegicus
OTHER WNK1 WNK1_RAT 5W7TA 2.01 Inactive DFGin‑BLBtrans out-na out-out nonTYR APEdihe_aaiii APEdist_oioi ANP ATPlike 210 - 482 0 SEP382 None Serine/threonine-protein kinase WNK1 Rattus norvegicus
OTHER WNK1 WNK1_RAT 5W7TB 2.01 Inactive DFGin‑BLBtrans out-na out-out nonTYR APEdihe_aaiii APEdist_oiii ANP ATPlike 210 - 482 0 SEP382 None Serine/threonine-protein kinase WNK1 Rattus norvegicus
AGC CBK1 CBK1_YEAST 4LQSA 3.3 Inactive None‑None none-none out-out nonTYR APEdihe_aaioo APEdist_oooo ANP ATPlike 294 - 749 0 None D475A Serine/threonine-protein kinase CBK1 Saccharomyces cerevisiae
AGC CBK1 CBK1_YEAST 5NCLA 3.15 Inactive None‑None none-none out-out nonTYR APEdihe_aaioo APEdist_oooo ANP ATPlike 266 - 756 0 None D475A Serine/threonine-protein kinase CBK1 Saccharomyces cerevisiae
AGC CBK1 CBK1_YEAST 4LQPA 4.5 Inactive None‑None none-none out-out nonTYR APEdihe_aaioo APEdist_oooo ANP ATPlike 282 - 749 0 None D475A,T743E Serine/threonine-protein kinase CBK1 Saccharomyces cerevisiae
AGC CBK1 CBK1_YEAST 4LQQA 3.6 Inactive None‑None none-none out-out nonTYR APEdihe_aaioo APEdist_oooo ANP ATPlike 282 - 749 0 None D475A,T743E Serine/threonine-protein kinase CBK1 Saccharomyces cerevisiae
CAMK RAD53 RAD53_YEAST 4PDSA 2.9 None DFGin‑BLAminus in-none in-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 191 - 490 0 None A225S,D339A Serine/threonine-protein kinase RAD53 Saccharomyces cerevisiae
CAMK RAD53 RAD53_YEAST 4PDSB 2.9 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aanoi APEdist_nnnn ANP ATPlike 191 - 494 0 None A225S,D339A Serine/threonine-protein kinase RAD53 Saccharomyces cerevisiae
CAMK RAD53 RAD53_YEAST 5XZVB 3.1 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaiii APEdist_iooo ANP ATPlike 32 - 466 0 None None Serine/threonine-protein kinase RAD53 Saccharomyces cerevisiae
CAMK RAD53 RAD53_YEAST 5XZVA 3.1 Inactive DFGin‑None in-out out-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 16 - 465 0 None None Serine/threonine-protein kinase RAD53 Saccharomyces cerevisiae
CMGC CKA1 CSK21_YEAST 4JQEA 1.77 Inactive None‑None out-na in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 3 - 371 0 None None Casein kinase II subunit alpha Saccharomyces cerevisiae
CMGC SKY1 SKY1_YEAST 1Q99A 2.11 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 143 - 737 0 None None Serine/threonine-protein kinase SKY1 Saccharomyces cerevisiae
CMGC SKY1 SKY1_YEAST 1Q99B 2.11 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 142 - 737 0 None None Serine/threonine-protein kinase SKY1 Saccharomyces cerevisiae
OTHER BUD32 BUD32_YEAST 4WW5A 1.997 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP Type1.5_Front 5 - 257 0 None None EKC/KEOPS complex subunit BUD32 Saccharomyces cerevisiae
OTHER GCN2-2 GCN2_YEAST 1ZY5A 2.0 Inactive DFGin‑BLBminus out-out out-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 594 - 996 0 None R794G eIF-2-alpha kinase GCN2 Saccharomyces cerevisiae
OTHER GCN2-2 GCN2_YEAST 1ZY5B 2.0 Inactive DFGin‑BLBminus out-out none-out nonTYR APEdihe_aaooi APEdist_nnno ANP ATPlike 594 - 983 0 None R794G eIF-2-alpha kinase GCN2 Saccharomyces cerevisiae
AGC PRKACA KAPCA_PIG 1CDKA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 9 - 351 0 TPO198 None cAMP-dependent protein kinase catalytic subunit alpha Sus scrofa
AGC PRKACA KAPCA_PIG 1CDKB 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 9 - 351 0 TPO198 None cAMP-dependent protein kinase catalytic subunit alpha Sus scrofa
OTHER RNASEL A5H025_PIG 4O1PA 2.5 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP, 25L ATPlike, Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa
OTHER RNASEL A5H025_PIG 4O1PB 2.5 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP, 25L ATPlike, Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa
OTHER RNASEL A5H025_PIG 4O1PC 2.5 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP, 25L ATPlike, Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa
OTHER RNASEL A5H025_PIG 4O1PD 2.5 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP, 25L ATPlike, Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa
OTHER TCUR0376 D1A2F7_THECD 8CAVA 2.87 Inactive DFGout‑None out-na in-out nonTYR APEdihe_aaiii APEdist_oiii ANP Allosteric 6 - 865 0 None None Serine/threonine protein kinase Thermomonospora curvata
OTHER TCUR0376 D1A2F7_THECD 8CAVB 2.87 Inactive DFGout‑None out-na in-out nonTYR APEdihe_aaiii APEdist_oiii ANP Allosteric 6 - 863 0 None None Serine/threonine protein kinase Thermomonospora curvata
CAMK CDPK1 Q9BJF5_TOXGO 4IEBA 2.05 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 32 - 507 0 None G128M non-specific serine/threonine protein kinase Toxoplasma gondii
CAMK CDPK1 Q9BJF5_TOXGO 3HX4A 1.95 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 30 - 503 0 None None non-specific serine/threonine protein kinase Toxoplasma gondii
CAMK CDPK1 Q9BJF5_TOXGO 3KU2A 2.3 Inactive None‑None out-none out-out nonTYR APEdihe_aaooi APEdist_oooo ANP ATPlike 44 - 507 0 None None non-specific serine/threonine protein kinase Toxoplasma gondii
OTHER ROP18 ROP18_TOXGO 4JRNA 2.71 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_inni ANP Allosteric 187 - 548 0 None None Serine/threonine-protein kinase ROP18 Toxoplasma gondii
OTHER PINK1 PINK1_TRICA 5YJ9D 2.53 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaiao APEdist_iiii ANP ATPlike 166 - 570 0 None S205D,S377D,T386E,T530E Serine/threonine-protein kinase Pink1, mitochondrial Tribolium castaneum
CMGC TVAG125560 A2F9N1_TRIV3 9AV7A 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 15 - 318 0 None None non-specific serine/threonine protein kinase Trichomonas vaginalis
CAMK AURKBA AUKBA_XENLA 4C2WA 1.7 Inactive DFGin‑ABAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 88 - 356 0 TPO248 None Aurora kinase B-A Xenopus laevis
CAMK AURKBA AUKBA_XENLA 4C2WB 1.7 Inactive DFGin‑ABAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 78 - 355 0 TPO248 None Aurora kinase B-A Xenopus laevis
CMGC ACK2 CSK2A_MAIZE 1DAWA 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 2 - 328 0 None None Casein kinase II subunit alpha Zea mays
CMGC ACK2 CSK2A_MAIZE 1LP4A 1.86 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ANP ATPlike 2 - 328 0 None None Casein kinase II subunit alpha Zea mays
OTHER SIRK1 K7VIQ3_MAIZE 5UV4A 2.3 Pseudo DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaono APEdist_oioo ANP ATPlike 744 - 1045 0 None None Putative leucine-rich repeat protein kinase family protein Zea mays