OTHER_RNASEL (2-5A-dependent ribonuclease)

Total number of chains: 3
Active chains: 0
Uniprot: RN5A_HUMAN
Kinase Domain Residues: 361 - 586
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 100.0% 4OAUC
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
4OAUC 2.6 Pseudo DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ADP ATPlike 25 - 719 0 None H672N 2-5A-dependent ribonuclease
4OAVB 2.1 Pseudo DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ACP ATPlike 24 - 717 0 None H672N 2-5A-dependent ribonuclease
4OAVD 2.1 Pseudo DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ACP ATPlike 26 - 719 0 None H672N 2-5A-dependent ribonuclease

OTHER_RNASEL (2-5A-dependent ribonuclease)

Total number of chains: 23
Active chains: 12
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 15 65.2% 6M12b
DFGin ABAminus 8 34.8% 4O1PB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
RN5A_HUMAN 4OAUC 2.6 Pseudo DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ADP ATPlike 25 - 719 0 None H672N 2-5A-dependent ribonuclease Homo sapiens
RN5A_HUMAN 4OAVB 2.1 Pseudo DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ACP ATPlike 24 - 717 0 None H672N 2-5A-dependent ribonuclease Homo sapiens
RN5A_HUMAN 4OAVD 2.1 Pseudo DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ACP ATPlike 26 - 719 0 None H672N 2-5A-dependent ribonuclease Homo sapiens
A5H025_PIG 6M11A 2.46 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25A, B49 Allosteric, Type1 22 - 727 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 6M11B 2.46 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25A, B49 Allosteric, Type1 23 - 727 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 6M12B 2.4 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25L, J60 Allosteric, Type1 24 - 726 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 7DSYA 2.651 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25A, HFX Allosteric, Type1 22 - 727 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 7DSYB 2.651 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25A, HFX Allosteric, Type1 23 - 727 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 7DTSA 2.63 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25A, 27K Allosteric, Type1 22 - 727 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 7DTSB 2.63 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25A, 27K Allosteric, Type1 23 - 727 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 7ELWA 3.55 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25L, MYC Allosteric, Type1 22 - 727 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 7ELWB 3.55 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25L, MYC Allosteric, Type1 23 - 727 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 6M12A 2.4 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa J60, 25L Type1, Allosteric 22 - 727 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 6M13A 2.56 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa BWC, 25L Type1, Allosteric 22 - 727 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 6M13B 2.56 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa BWC, 25L Type1, Allosteric 23 - 729 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 4O1PA 2.5 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP, 25L ATPlike, Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 4O1PB 2.5 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP, 25L ATPlike, Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 4O1PC 2.5 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP, 25L ATPlike, Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 4O1PD 2.5 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP, 25L ATPlike, Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 4O1OA 3.27 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25L Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 4O1OB 3.27 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25L Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 4O1OC 3.27 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25L Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 4O1OD 3.27 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25L Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa

OTHER_RNASEL (2-5A-dependent ribonuclease)

Total number of chains: 20
Active chains: 12
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 12 60.0% 6M12b
DFGin ABAminus 8 40.0% 4O1PB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
A5H025_PIG 6M11A 2.46 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25A, B49 Allosteric, Type1 22 - 727 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 6M11B 2.46 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25A, B49 Allosteric, Type1 23 - 727 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 6M12B 2.4 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25L, J60 Allosteric, Type1 24 - 726 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 7DSYA 2.651 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25A, HFX Allosteric, Type1 22 - 727 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 7DSYB 2.651 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25A, HFX Allosteric, Type1 23 - 727 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 7DTSA 2.63 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25A, 27K Allosteric, Type1 22 - 727 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 7DTSB 2.63 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25A, 27K Allosteric, Type1 23 - 727 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 7ELWA 3.55 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25L, MYC Allosteric, Type1 22 - 727 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 7ELWB 3.55 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25L, MYC Allosteric, Type1 23 - 727 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 6M12A 2.4 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa J60, 25L Type1, Allosteric 22 - 727 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 6M13A 2.56 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa BWC, 25L Type1, Allosteric 22 - 727 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 6M13B 2.56 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa BWC, 25L Type1, Allosteric 23 - 729 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 4O1PA 2.5 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP, 25L ATPlike, Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 4O1PB 2.5 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP, 25L ATPlike, Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 4O1PC 2.5 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP, 25L ATPlike, Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 4O1PD 2.5 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa ANP, 25L ATPlike, Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 4O1OA 3.27 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25L Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 4O1OB 3.27 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25L Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 4O1OC 3.27 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25L Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa
A5H025_PIG 4O1OD 3.27 Inactive DFGin‑ABAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 25L Allosteric 22 - 729 0 None None Ribonuclease L Sus scrofa