All / DFGoutNone / All

Total number of chains: 323
Active chains: 0
Total number of genes: 72
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 323 100.0% 3G0EA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AGC AKT1 AKT1_HUMAN 5KCVA 2.7 Inactive DFGout‑None none-none none-none nonTYR APEdihe_aannn APEdist_nnnn 6S1 Allosteric 6 - 438 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 7APJA 2.05 Inactive DFGout‑None none-none none-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 3 - 439 0 None S2N RAC-alpha serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 1GZKA 2.3 Inactive DFGout‑None in-none none-out nonTYR APEdihe_aanoo APEdist_nnnn No_ligand No_ligand 146 - 441 0 None None RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 1GZOA 2.75 Inactive DFGout‑None in-none none-out nonTYR APEdihe_aanoo APEdist_nnnn No_ligand No_ligand 146 - 442 0 None None RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 1GZNA 2.5 Inactive DFGout‑None in-none none-out nonTYR APEdihe_aanoo APEdist_nnnn No_ligand No_ligand 146 - 442 0 None None RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 1MRVA 2.8 Inactive DFGout‑None none-none none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 147 - 440 0 None None RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 1MRYA 2.8 Inactive DFGout‑None none-none none-out nonTYR APEdihe_aaioo APEdist_nnio No_ligand No_ligand 146 - 440 0 None None RAC-beta serine/threonine-protein kinase
AGC PDPK1 PDPK1_HUMAN 3QC4B 1.8 Inactive DFGout‑None out-out in-in nonTYR APEdihe_aaiii APEdist_iiii MP7 Type2 51 - 359 0 SEP241 E303A,K304A 3-phosphoinositide-dependent protein kinase 1
AGC ROCK1 ROCK1_HUMAN 7S25A 2.337 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaiii APEdist_nnno 86G Type1 7 - 401 0 None None Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 7S25B 2.337 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaiii APEdist_iioo 86G Type1 8 - 402 0 None None Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 7S25C 2.337 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn 86G Type1 13 - 402 0 None None Rho-associated protein kinase 1
AGC ROCK2 ROCK2_HUMAN 9JCUB 3.02 Inactive DFGout‑None out-out in-out nonTYR APEdihe_aaioi APEdist_iooi No_ligand No_ligand 27 - 417 0 None None Rho-associated protein kinase 2
AGC ROCK2 ROCK2_HUMAN 9JCUD 3.02 Inactive DFGout‑None out-out in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 27 - 417 0 None None Rho-associated protein kinase 2
AGC RPS6KA3-1 KS6A3_HUMAN 8EQ5A 1.8 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_iioo QCT Type1 49 - 346 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8R58A 2.31 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_nioo QCT Type1 49 - 348 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYA 3.2 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nooo A1LU8 Type1 58 - 358 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYB 3.2 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nooo A1LU8 Type1 59 - 358 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYC 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_nooo A1LU8 Type1 61 - 358 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYD 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nooo A1LU8 Type1 63 - 348 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYE 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nooi A1LU8 Type1 64 - 348 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYF 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nooo A1LU8 Type1 63 - 345 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYG 3.2 Inactive DFGout‑None in-out out-out nonTYR APEdihe_aaiii APEdist_nooi A1LU8 Type1 59 - 346 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYH 3.2 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nooi A1LU8 Type1 59 - 348 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYI 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nooo A1LU8 Type1 63 - 348 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYJ 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_nooi A1LU8 Type1 65 - 347 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 4NUSA 2.39 Inactive DFGout‑None in-out out-out nonTYR APEdihe_aaiii APEdist_iooi 2NK Type1 53 - 359 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 5D9LA 2.15 Inactive DFGout‑None in-out out-out nonTYR APEdihe_aaiii APEdist_nnno 583 Type1 49 - 359 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 5D9KA 2.55 Inactive DFGout‑None in-out out-out nonTYR APEdihe_aaiii APEdist_nnoi 584 Type1 62 - 359 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 5D9KB 2.55 Inactive DFGout‑None in-none out-out nonTYR APEdihe_aaiii APEdist_nnoi 584 Type1 62 - 359 0 None None Ribosomal protein S6 kinase alpha-3
AGC SGK1 SGK1_HUMAN 7PUEA 2.506 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaioo APEdist_oooo 86H Type1 82 - 376 0 None R192A,S422D Serine/threonine-protein kinase Sgk1
CAMK AURKA AURKA_HUMAN 6VPJA 2.1 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaooi APEdist_iioo ANP ATPlike 104 - 389 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPHA 2.14 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo ANP ATPlike 7 - 389 0 TPO287,TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 4JAIA 3.2 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aanno APEdist_nnnn XU2 Type1 126 - 390 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 7AYHA 2.8 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn S9H Type1 125 - 390 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 7O2VA 3.1 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo V0K Type1 117 - 390 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 3O51A 3.2 Inactive DFGout‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn LJF Type1.5_Front 126 - 388 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 6HJKA 2.4 Inactive DFGout‑None out-none out-out nonTYR APEdihe_aaoii APEdist_nnoo G7W Type1.5_Front 127 - 391 0 None L210C,C290A,C393A Aurora kinase A
CAMK MELK MELK_HUMAN 5K00A 1.77 Inactive DFGout‑None out-in out-none nonTYR APEdihe_aanii APEdist_nnnn 6PV Type2 3 - 327 0 None None Maternal embryonic leucine zipper kinase
CAMK MKNK1 MKNK1_HUMAN 5WVDA 3.0 Inactive DFGout‑None in-out out-none nonTYR APEdihe_aannn APEdist_nnnn 7UX Type1 41 - 375 0 None None MAP kinase-interacting serine/threonine-protein kinase 1
CAMK MKNK1 MKNK1_HUMAN 5WVDB 3.0 Inactive DFGout‑None in-out out-none nonTYR APEdihe_aannn APEdist_nnnn 7UX Type1 41 - 374 0 None None MAP kinase-interacting serine/threonine-protein kinase 1
CAMK MKNK2 MKNK2_HUMAN 6JLRA 2.901 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaioi APEdist_nnno BV9 Type1 72 - 369 0 None None MAP kinase-interacting serine/threonine-protein kinase 2
CMGC CDK16 CDK16_HUMAN 3MTLA 2.4 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn FEF Type1 163 - 473 0 None S319D Cyclin-dependent kinase 16
CMGC CDK16 CDK16_HUMAN 5G6VB 2.2 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaoii APEdist_nnno 919 Type2 163 - 475 0 None S319D Cyclin-dependent kinase 16
CMGC CDK2 CDK2_HUMAN 5A14A 2.0 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaioi APEdist_nnno LQ5, LQ5 Type2, Allosteric 1 - 296 0 None None Cyclin-dependent kinase 2
CMGC CLK3 CLK3_HUMAN 9EZ3A 2.7 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aaiii APEdist_nnni A1H74 Type2 136 - 481 0 None None Dual specificity protein kinase CLK3
CMGC MAPK11 MK11_HUMAN 8YGWA 3.301 Inactive DFGout‑None in-out none-out nonTYR APEdihe_aaoii APEdist_nnno B96 Type2 5 - 348 0 None None Mitogen-activated protein kinase 11
CMGC MAPK13 MK13_HUMAN 5EKNA 2.594 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaioi APEdist_nnno N58 Type2 2 - 351 0 None None Mitogen-activated protein kinase 13
CMGC MAPK14 MK14_HUMAN 5N64A 2.4 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno 8OH Allosteric 5 - 354 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 5N66A 2.4 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno BW1, B96 Allosteric, Type2 6 - 353 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4EH8A 2.2 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno IRG, 0OP, 0OP Allosteric, Type3, Type1 4 - 354 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 2FSMX 1.86 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaiii APEdist_nnno No_ligand No_ligand 4 - 352 0 None D176A,F327S Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 2NPQA 1.8 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaiii APEdist_nnno No_ligand No_ligand 4 - 351 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4GEOA 1.66 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aanii APEdist_nnnn No_ligand No_ligand 5 - 351 0 None M194A,L195A,H228A,I229A,Y258A Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3MH3A 2.2 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno No_ligand No_ligand 5 - 352 0 None F169R Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3MH1A 2.2 Inactive DFGout‑None in-out none-out nonTYR APEdihe_aaoii APEdist_nnoo No_ligand No_ligand 5 - 352 0 None F169G Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3IW5A 2.5 Inactive DFGout‑None in-out none-out nonTYR APEdihe_aaooi APEdist_nnno DF3 Type1 4 - 353 0 None C119S,C162S,A172C,F327L Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3L8SA 2.35 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno BFF Type1 4 - 353 0 None C119S,C162S,A172C,F327L Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 6SFKA 1.8 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnoo LB8 Type2 4 - 353 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3HECA 2.5 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno STI Type2 5 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3NNUA 2.4 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaooi APEdist_oooo EDB Type2 5 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3NNWA 1.89 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaooi APEdist_oooo EDD Type2 4 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 1KV2A 2.8 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aanii APEdist_nnnn B96 Type2 5 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 1WBSA 1.8 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaoii APEdist_oooo LI2 Type2 4 - 355 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 1WBTA 2.0 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaoii APEdist_oooo WBT Type2 4 - 355 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 9CJ1A 1.8 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno NIL Type2 5 - 351 0 TPO180,PTR182 None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3UVRA 2.1 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno 06F Type2 5 - 351 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4L8MA 2.1 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaooi APEdist_nnoo F46 Type2 5 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3BV3A 2.59 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nioo P39 Type2 5 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 2YISA 2.0 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno YIS, I46 Type2, Allosteric 5 - 353 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 2YIWA 2.0 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno YIW, I46 Type2, Allosteric 5 - 353 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 9CJ5A 3.3 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nooo A1AWV, PDO Type2, Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3K3JA 1.995 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno F4C, I46 Type2, Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3LFDA 3.4 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno Z85 Type3 4 - 353 0 None C119S,C162S,A172C,F327L Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 1KV1A 2.5 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno BMU Type3 5 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3O8TA 2.0 Inactive DFGout‑None in-out none-out nonTYR APEdihe_aaooi APEdist_nnno BMU Type3 5 - 352 0 None F169A Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3OC1A 2.59 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno BMU Type3 5 - 352 0 None F169G Mitogen-activated protein kinase 14
CMGC MAPK6 MK06_HUMAN 6YLCA 2.43 Inactive DFGout‑None in-out out-out nonTYR APEdihe_aaiii APEdist_oooo OXW Type1 15 - 320 0 None L290V Mitogen-activated protein kinase 6
CMGC MAPK9 MK09_HUMAN 3NPCA 2.35 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaoii APEdist_oioo B96 Type2 7 - 363 0 None D3K,C6V,S8N,Q14E,K203A,E204A,K250A,K251A Mitogen-activated protein kinase 9
CMGC MAPK9 MK09_HUMAN 3NPCB 2.35 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaoii APEdist_oioo B96 Type2 8 - 363 0 None D3K,C6V,S8N,Q14E,K203A,E204A,K250A,K251A Mitogen-activated protein kinase 9
CMGC PRP4K PRP4K_HUMAN 6CNHA 2.0 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno 919 Type2 657 - 1005 0 None None Serine/threonine-protein kinase PRP4 homolog
NEK NEK2 NEK2_HUMAN 2XK3A 2.2 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno XK3 Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
NEK NEK2 NEK2_HUMAN 2XK4A 2.1 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nooo OL2 Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
NEK NEK2 NEK2_HUMAN 2XK8A 2.001 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno 5R1 Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
NEK NEK2 NEK2_HUMAN 2XNPA 1.98 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nooo WCX Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
NEK NEK2 NEK2_HUMAN 4AFEA 2.597 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaioo APEdist_nnoo GGY Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2
NEK NEK2 NEK2_HUMAN 4A4XA 2.4 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnoo JUP Type1 3 - 271 0 None T170E,S171D,T175E Serine/threonine-protein kinase Nek2
NEK NEK7 NEK7_HUMAN 5DE2A 2.78 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaooo APEdist_nnno No_ligand No_ligand 20 - 300 0 None Y97F Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 6S75D 3.3 Inactive DFGout‑None out-none none-out nonTYR APEdihe_aanoo APEdist_nnnn No_ligand No_ligand 28 - 299 0 None None Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8WS0A 2.12 Inactive DFGout‑None out-out out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 20 - 300 0 None S195D Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8SXNA 4.04 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aaioo APEdist_oiio No_ligand No_ligand 19 - 302 0 None None Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8SXNB 4.04 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aaioo APEdist_oiio No_ligand No_ligand 19 - 302 0 None None Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 8WS1A 2.4 Inactive DFGout‑None out-out out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 20 - 300 0 None D161N Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 6S75A 3.3 Inactive DFGout‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn F9N Type1 19 - 300 0 None None Serine/threonine-protein kinase Nek7
OTHER EIF2AK3 E2AK3_HUMAN 4X7HA 2.0 Inactive DFGout‑None out-out none-none nonTYR APEdihe_aanii APEdist_nnnn 3Z2 Type2 585 - 1086 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKA 2.3 Inactive DFGout‑None out-none none-out nonTYR APEdihe_aaoni APEdist_nnno G41 Type1 583 - 998 0 None D848N eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKB 2.3 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaoni APEdist_nnno G41 Type1 583 - 998 0 None D848N eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKC 2.3 Inactive DFGout‑None out-out out-none nonTYR APEdihe_aanni APEdist_nnnn G41 Type1 583 - 1004 0 None D848N eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKD 2.3 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaoni APEdist_nnno G41 Type1 583 - 1003 0 None D848N eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKE 2.3 Inactive DFGout‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn G41 Type1 584 - 1004 0 None D848N eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKG 2.3 Inactive DFGout‑None out-out out-none nonTYR APEdihe_aanni APEdist_nnnn G41 Type1 584 - 1007 0 None D848N eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 6N3LA 2.61 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aanni APEdist_nnnn KAV Type2 584 - 1002 0 None K807A,D848N,T899A,T904A eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 6N3LB 2.61 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aanni APEdist_nnnn KAV Type2 584 - 1002 0 None K807A,D848N,T899A,T904A eIF-2-alpha kinase GCN2
OTHER ERN1 ERN1_HUMAN 4YZ9A 2.463 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnno 4K7 Type3 562 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZ9B 2.463 Inactive DFGout‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn 4K7 Type3 563 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZ9C 2.463 Inactive DFGout‑None out-out none-none nonTYR APEdihe_aanii APEdist_nnnn 4K7 Type3 562 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER MLKL MLKL_HUMAN 6O5ZB 2.285 Pseudo DFGout‑None in-out none-out nonTYR APEdihe_aaoii APEdist_nnno LN4 Type2 190 - 467 0 None None Mixed lineage kinase domain-like protein
STE MAP2K1 MP2K1_HUMAN 5HZEA 2.4 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaioi APEdist_oooo E62 Type1 43 - 382 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 8YP4B 2.35 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aanoo APEdist_nnnn WNT Type1 43 - 383 0 None T286A,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K6 MP2K6_HUMAN 8P7JA 2.4 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aannn APEdist_nnnn X3K Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 8P7JB 2.4 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aanao APEdist_nnnn X3K Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 8PM3A 2.0 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aanao APEdist_nnnn ZLE Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 8PM3B 2.0 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aanao APEdist_nnnn ZLE Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 8PM3C 2.0 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aanao APEdist_nnnn ZLE Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K6 MP2K6_HUMAN 8PM3D 2.0 Inactive DFGout‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn ZLE Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6
STE MAP2K7 MP2K7_HUMAN 6YZ4A 1.7 Inactive DFGout‑None in-na out-out nonTYR APEdihe_aaoai APEdist_nnno 1E8 Allosteric 101 - 404 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 5Y8UA 2.92 Inactive DFGout‑None out-na none-out nonTYR APEdihe_aaiao APEdist_nnoo No_ligand No_ligand 103 - 402 0 None C260S Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 5Y90A 1.3 Inactive DFGout‑None in-na out-out nonTYR APEdihe_aaiai APEdist_nnoi No_ligand No_ligand 103 - 419 0 None C202S Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 5B2LA 2.1 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aaiai APEdist_nnni No_ligand No_ligand 104 - 403 0 None C202S Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6YFZA 1.9 Inactive DFGout‑None in-na out-out nonTYR APEdihe_aaoai APEdist_nnno No_ligand No_ligand 100 - 405 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6QFRA 2.3 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 5B2KA 2.75 Inactive DFGout‑None out-na none-out nonTYR APEdihe_aaoai APEdist_nnno No_ligand No_ligand 104 - 400 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6YG0A 2.0 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 102 - 402 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 7CBXA 2.061 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aanai APEdist_nnnn FU6 Type1 103 - 402 0 None C202S Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 5Z1EA 2.3 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aaiai APEdist_nnni 95U Type1 103 - 419 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6YG4A 2.3 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aannn APEdist_nnnn SU9 Type1 103 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6YG5A 2.4 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aannn APEdist_nnnn IHH Type1 101 - 403 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 3WZUA 3.01 Inactive DFGout‑None none-na none-out nonTYR APEdihe_aaoai APEdist_nnno 1FM Type1 104 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6YG6A 2.15 Inactive DFGout‑None out-na none-out nonTYR APEdihe_aaiao APEdist_nnno OQ8 Type2 103 - 403 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7
STE MAP2K7 MP2K7_HUMAN 6YG6B 2.15 Inactive DFGout‑None out-na none-out nonTYR APEdihe_aaiao APEdist_nnno OQ8 Type2 104 - 403 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7
STE MAP3K2 M3K2_HUMAN 9P6AB 2.4 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaioi APEdist_nnoo 0LI Type2 347 - 618 0 None None Mitogen-activated protein kinase kinase kinase 2
STE MAP3K5 M3K5_HUMAN 8QGYA 3.71 Inactive DFGout‑None in-out in-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 95 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP4K1 M4K1_HUMAN 9N7RA 2.13 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo A1BWC, A1BWC, A1BWC, A1BWC Allosteric, Allosteric, Type1, Type3 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8PAUA 2.8 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiii APEdist_nnno XOR Type1 7 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8PAUB 2.8 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiii APEdist_nnno XOR Type1 7 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8PASA 2.7 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn XOH Type1 8 - 295 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8PASB 2.7 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn XOH Type1 7 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8CDWA 1.941 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno UES Type1 7 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8CIJA 2.821 Inactive DFGout‑None out-out none-none nonTYR APEdihe_aaiii APEdist_nnni USF Type1 14 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8PARA 2.0 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno XON Type1 7 - 294 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K4 M4K4_HUMAN 4U3ZB 2.09 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 14 - 311 0 None T181E Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4ZP5B 2.29 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 10 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 5DI1B 2.9 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 10 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 5J95B 2.5 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 10 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 8V5IB 2.18 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 16 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4RVTB 2.4 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4OBOB 2.1 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 12 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4OBPB 2.27 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 14 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4OBQB 2.19 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4U40B 2.3 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4U41B 2.2 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 12 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4U43B 2.18 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 10 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4U44B 2.43 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 14 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4U45B 2.58 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4ZK5B 2.89 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 5W5QB 2.33 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE PAK1 PAK1_HUMAN 4ZLOA 2.5 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaioo APEdist_nnno 4PV Type3 250 - 543 0 TPO423 None Serine/threonine-protein kinase PAK 1
STE PAK2 PAK2_HUMAN 9M41B 3.02 Inactive DFGout‑None out-none out-out nonTYR APEdihe_aaiio APEdist_nnno No_ligand No_ligand 83 - 521 0 None K278R,D368N Serine/threonine-protein kinase PAK 2
STE STK10 STK10_HUMAN 4AOTA 2.33 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaiio APEdist_nnno GW8 Type1 18 - 314 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 4AOTB 2.33 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaiio APEdist_nnoo GW8 Type1 18 - 314 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 4USDA 3.05 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno R09 Type1 24 - 314 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 4USDB 3.05 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno R09 Type1 24 - 314 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 4EQUA 2.0 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaiii APEdist_nnoo G6I Type2 24 - 317 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 4EQUB 2.0 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaiii APEdist_nooo G6I Type2 24 - 317 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 6I2YA 2.56 Inactive DFGout‑None out-out in-out nonTYR APEdihe_aaiii APEdist_nnoo 88Z Type2 24 - 317 0 None None Serine/threonine-protein kinase 10
STE STK10 STK10_HUMAN 6I2YB 2.56 Inactive DFGout‑None out-none out-out nonTYR APEdihe_aaini APEdist_nnoo 88Z Type2 24 - 317 0 None None Serine/threonine-protein kinase 10
STE STK26 STK26_HUMAN 4FZAB 3.15 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo No_ligand No_ligand 18 - 297 0 None D162A Serine/threonine-protein kinase 26
STE STK26 STK26_HUMAN 4FZDB 3.25 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iooo No_ligand No_ligand 18 - 297 0 None D162A Serine/threonine-protein kinase 26
TKL BRAF BRAF_HUMAN 4RZWA 3.493 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaiii APEdist_nnno B1E Type1 448 - 720 0 None R509H,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 3C4CB 2.57 Inactive DFGout‑None in-out none-out nonTYR APEdihe_aaiii APEdist_nnno 324 Type1.5_Back 448 - 721 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 4RZWB 3.493 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaiii APEdist_nnno B1E Type2 448 - 721 0 None R509H,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 6CADB 2.55 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno EU4 Type2 449 - 721 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 6NSQB 3.05 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno KZP Type2 447 - 722 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 8QQGA 2.979 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaiii APEdist_nnno WJ9 Type2 449 - 722 0 None None Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 5CT7B 3.17 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 55J Type2 449 - 721 0 None None Serine/threonine-protein kinase B-raf
TKL IRAK4 IRAK4_HUMAN 6EG9A 2.414 Inactive DFGout‑None in-out none-none nonTYR APEdihe_aaiii APEdist_nnni 0LI Type2 164 - 459 0 None None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6EG9B 2.414 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aaiii APEdist_nnni 0LI Type2 165 - 459 0 None None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6EGAA 2.512 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoio APEdist_nnni J8A Type2 166 - 459 0 None None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6EGAB 2.512 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aaiii APEdist_nnni J8A Type2 164 - 459 0 None None Interleukin-1 receptor-associated kinase 4
TKL LIMK2 LIMK2_HUMAN 5NXDA 1.9 Inactive DFGout‑None out-out out-none nonTYR APEdihe_aannn APEdist_nnnn 9D8 Type3 330 - 632 0 None None LIM domain kinase 2
TKL LRRK1 LRRK1_HUMAN 8E04A 3.8 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 381 - 2007 0 None None Leucine-rich repeat serine/threonine-protein kinase 1
TKL LRRK1 LRRK1_HUMAN 8E05A 4.6 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 51 - 2007 0 None None Leucine-rich repeat serine/threonine-protein kinase 1
TKL LRRK1 LRRK1_HUMAN 8E05B 4.6 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 51 - 2007 0 None None Leucine-rich repeat serine/threonine-protein kinase 1
TKL LRRK1 LRRK1_HUMAN 8E06A 4.3 Inactive DFGout‑None in-out none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 51 - 2007 0 None None Leucine-rich repeat serine/threonine-protein kinase 1
TKL LRRK1 LRRK1_HUMAN 8FACA 3.92 Inactive DFGout‑None in-out out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 341 - 2013 0 None None Leucine-rich repeat serine/threonine-protein kinase 1
TKL LRRK2 LRRK2_HUMAN 8FO9E 3.48 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 9DMIA 3.35 Inactive DFGout‑None in-out none-out nonTYR APEdihe_aaioi APEdist_nnoi A1A7Q Type2 1334 - 2526 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8TZEA 2.9 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn T3X Type2 1624 - 2522 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8TZFA 3.4 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn T3X Type2 587 - 2522 0 None I2020T Leucine-rich repeat serine/threonine-protein kinase 2
TKL MAP3K7 M3K7_HUMAN 5J9LA 2.752 Inactive DFGout‑None in-out none-out nonTYR APEdihe_aaoii APEdist_nnno 6HF Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7
TKL MAP3K7 M3K7_HUMAN 5J7SA 2.368 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaoii APEdist_nnno 6H3 Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7
TKL MAP3K7 M3K7_HUMAN 5GJFA 2.89 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaooi APEdist_iiio 6V4 Type2 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7
TKL RIPK2 RIPK2_HUMAN 4C8BA 2.75 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoni APEdist_nnno 0LI Type2 8 - 316 0 None None Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 4C8BB 2.75 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno 0LI Type2 9 - 316 0 None None Receptor-interacting serine/threonine-protein kinase 2
TKL RIPK2 RIPK2_HUMAN 5AR7A 2.71 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn SR8 Type2 6 - 310 0 None None Receptor-interacting serine/threonine-protein kinase 2
TYR ABL1 ABL1_HUMAN 2G2FB 2.7 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai AGS ATPlike 234 - 502 0 None H396P Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 6XR7A 999.0 Inactive DFGout‑None in-in out-out TYR APEdihe_ooiai APEdist_aaai No_ligand No_ligand 229 - 515 0 None None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 8I7TB 2.8 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai 6I5 Type1 232 - 500 0 PTR393 None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2HZIA 1.7 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai JIN Type1 233 - 500 0 None None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 4ZOGB 2.3 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai VX6 Type1 234 - 503 0 None None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 4WA9B 2.2 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai AXI Type1 246 - 508 0 None None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 3UE4A 2.424 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai DB8 Type1 233 - 502 0 None None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 3UE4B 2.424 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai DB8 Type1 233 - 502 0 None None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 8I7TA 2.8 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai 6I5 Type1.5_Back 232 - 500 0 PTR393 None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2HZIB 1.7 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai JIN Type1.5_Back 233 - 500 0 None None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2G2HB 2.0 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai P16 Type1.5_Back 233 - 504 0 None H396P Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2FO0A 2.27 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai P16 Type1.5_Back 46 - 511 0 SEP50 D363N Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 1OPLA 3.42 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai P16 Type1.5_Back 62 - 512 0 None K12R,D363N Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 1OPLB 3.42 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai P16 Type1.5_Back 121 - 499 0 None K12R,D363N Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 5MO4A 2.17 Inactive DFGout‑None in-in none-out TYR APEdihe_nnoai APEdist_aaao NIL, AY7 Type2, Allosteric 64 - 512 0 None None Tyrosine-protein kinase ABL1
TYR ALK ALK_HUMAN 4FNYA 2.45 Inactive DFGout‑None in-in none-out TYR APEdihe_oiiai APEdist_aaao I3K Type2 1103 - 1404 0 None C1097S,R1275Q ALK tyrosine kinase receptor
TYR CSF1R CSF1R_HUMAN 2OGVA 2.7 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 543 - 918 0 None None Macrophage colony-stimulating factor 1 receptor
TYR DDR1 DDR1_HUMAN 5BVWA 1.94 Inactive DFGout‑None in-in none-in TYR APEdihe_iiiai APEdist_aaai 1N1 Type1 604 - 911 0 None None Epithelial discoidin domain-containing receptor 1
TYR DDR1 DDR1_HUMAN 5SB2A 1.6 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai 1K2 Type2 603 - 912 0 None None Epithelial discoidin domain-containing receptor 1
TYR DDR1 DDR1_HUMAN 5BVKA 2.29 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai 4VC Type3 604 - 911 0 None None Epithelial discoidin domain-containing receptor 1
TYR EGFR EGFR_HUMAN 4I1ZA 3.0 Inactive DFGout‑None out-out in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 701 - 987 0 None T790M,L858R,V948R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4I21A 3.37 Inactive DFGout‑None out-out in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 703 - 1019 0 None T790M,L858R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4I21B 3.37 Inactive DFGout‑None out-out in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 703 - 1020 0 None T790M,L858R Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2RF9B 3.5 Inactive DFGout‑None out-none in-out TYR APEdihe_ioiai APEdist_aaao No_ligand No_ligand 701 - 985 0 None None Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4I20A 3.34 Inactive DFGout‑None out-out in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 701 - 987 0 None L858R,V948R Epidermal growth factor receptor
TYR EPHA2 EPHA2_HUMAN 5IA4A 1.797 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 88Z Type2 605 - 877 0 None None Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 5IA5A 1.776 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai GV0 Type2 605 - 880 0 None None Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 6Q7FA 1.204 Inactive DFGout‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan HNZ Type2 605 - 896 0 None None Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 8BOFA 1.82 Inactive DFGout‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan R3L Type2 605 - 896 0 None None Ephrin type-A receptor 2
TYR EPHA3 EPHA3_HUMAN 4P5ZA 2.002 Inactive DFGout‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan Q7M Type2 609 - 903 0 None None Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 4TWNA 1.706 Inactive DFGout‑None in-in out-none TYR APEdihe_niiai APEdist_aaai B96 Type2 609 - 904 0 None None Ephrin type-A receptor 3
TYR ERBB2 ERBB2_HUMAN 8U8XA 1.69 Inactive DFGout‑None out-out out-out TYR APEdihe_iiiai APEdist_aaao W9N Type1 712 - 1024 0 None None Receptor tyrosine-protein kinase erbB-2
TYR FGFR1 FGFR1_HUMAN 4V01A 2.33 Inactive DFGout‑None in-in none-out TYR APEdihe_iioai APEdist_aaao 0LI Type2 465 - 765 0 None C488A,C584S Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 4V01B 2.33 Inactive DFGout‑None in-in none-out TYR APEdihe_iioai APEdist_aaao 0LI Type2 461 - 763 0 None C488A,C584S Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 4V04A 2.12 Inactive DFGout‑None in-in none-out TYR APEdihe_iioai APEdist_aaao 0LI Type2 463 - 765 0 None C488A,C584S Fibroblast growth factor receptor 1
TYR FGFR4 FGFR4_HUMAN 4QRCA 1.901 Inactive DFGout‑None in-in out-out TYR APEdihe_iioai APEdist_aaao 0LI Type2 454 - 750 0 None C477A,R664E Fibroblast growth factor receptor 4
TYR FGR FGR_HUMAN 7UY3A 2.99 Inactive DFGout‑None in-in out-none TYR APEdihe_nniai APEdist_aaai OJL Type2 135 - 527 0 PTR523 Q524E,P525E,G526I,D527P Tyrosine-protein kinase Fgr
TYR FLT3 FLT3_HUMAN 1RJBA 2.1 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 572 - 947 0 None None Receptor-type tyrosine-protein kinase FLT3
TYR FLT3 FLT3_HUMAN 6JQRA 2.2 Inactive DFGout‑None in-in none-in TYR APEdihe_iiiai APEdist_aaai C6F Type1 571 - 951 0 None None Receptor-type tyrosine-protein kinase FLT3
TYR FLT3 FLT3_HUMAN 8XB1A 2.85 Inactive DFGout‑None in-in none-in TYR APEdihe_iiiai APEdist_aaai ZX3 Type1 573 - 950 0 None None Receptor-type tyrosine-protein kinase FLT3
TYR FLT3 FLT3_HUMAN 5X02A 2.401 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai F6M Type1 573 - 947 0 None None Receptor-type tyrosine-protein kinase FLT3
TYR FLT3 FLT3_HUMAN 6IL3A 2.5 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai A9R Type1 569 - 947 0 None None Receptor-type tyrosine-protein kinase FLT3
TYR IGF1R IGF1R_HUMAN 3O23A 2.1 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai MQY Type2 991 - 1283 0 None Y987F Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYJAAA 2.702 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai IEA Type2 986 - 1270 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYKAAA 2.23 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai IC2 Type2 986 - 1270 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYLAAA 2.93 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai IE0 Type2 986 - 1270 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYMAAA 2.652 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai IED Type2 984 - 1270 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 8PYNAAA 1.71 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai ICV Type2 986 - 1270 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 3LW0D 1.79 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai CCX, CCX Type3, Allosteric 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
TYR KDR VGFR2_HUMAN 3C7QA 2.1 Inactive DFGout‑None in-in none-out TYR APEdihe_iioai APEdist_aaao XIN Type1 819 - 1171 0 PTR1054,PTR1059 None Vascular endothelial growth factor receptor 2
TYR KDR VGFR2_HUMAN 2P2IB 2.4 Inactive DFGout‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan 608 Type1 820 - 1168 0 PTR1054,PTR1059 C817A,E990V Vascular endothelial growth factor receptor 2
TYR KDR VGFR2_HUMAN 3VNTA 1.64 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai 0JA Type2 812 - 1168 0 None None Vascular endothelial growth factor receptor 2
TYR KDR VGFR2_HUMAN 3VO3A 1.52 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai 0KF Type2 812 - 1168 0 None None Vascular endothelial growth factor receptor 2
TYR KDR VGFR2_HUMAN 2QU6B 2.1 Inactive DFGout‑None in-in none-out TYR APEdihe_nniai APEdist_aaao 857 Type2 822 - 1165 0 PTR1054,PTR1059 C817A,V916T,E990V Vascular endothelial growth factor receptor 2
TYR KDR VGFR2_HUMAN 3B8QA 2.75 Inactive DFGout‑None in-in none-out TYR APEdihe_nnoai APEdist_aaao 900 Type2 818 - 1171 0 PTR1054,PTR1059 C817A,V916T,E990V Vascular endothelial growth factor receptor 2
TYR KDR VGFR2_HUMAN 3CPBA 2.7 Inactive DFGout‑None in-in none-out TYR APEdihe_nnoai APEdist_aaao C92 Type2 819 - 1171 0 PTR1054,PTR1059 C817A,V916T,E990V Vascular endothelial growth factor receptor 2
TYR KDR VGFR2_HUMAN 3CPCA 2.4 Inactive DFGout‑None in-out none-out TYR APEdihe_nnoai APEdist_aaao C52 Type2 820 - 1171 0 PTR1054,PTR1059 C817A,V916T,E990V Vascular endothelial growth factor receptor 2
TYR KDR VGFR2_HUMAN 3DTWA 2.9 Inactive DFGout‑None in-in none-out TYR APEdihe_nnoai APEdist_aaao A96 Type2 818 - 1171 0 PTR1054,PTR1059 C817A,V916T,E990V Vascular endothelial growth factor receptor 2
TYR KIT KIT_HUMAN 1T45A 1.9 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 547 - 935 0 None None Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 3G0EA 1.6 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai B49 Type1 544 - 931 0 None None Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 8S1BA 2.0 Inactive DFGout‑None in-in none-in TYR APEdihe_iiiai APEdist_aaai K3R Type2 565 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
TYR LCK LCK_HUMAN 2OFVA 2.0 Inactive DFGout‑None in-in none-none TYR APEdihe_nnnan APEdist_aaan 242 Type2 232 - 498 0 None None Tyrosine-protein kinase Lck
TYR LCK LCK_HUMAN 2OFVB 2.0 Inactive DFGout‑None in-in out-none TYR APEdihe_nnnai APEdist_aaan 242 Type2 232 - 498 0 None None Tyrosine-protein kinase Lck
TYR MERTK MERTK_HUMAN 7AVXB 2.44 Inactive DFGout‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan S4K Type1 577 - 862 0 None None Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 9KRZA 2.6 Inactive DFGout‑None out-none none-none TYR APEdihe_nnnai APEdist_aaan A1L6K Type1.5_Front 577 - 864 0 None None Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 9KRZB 2.6 Inactive DFGout‑None out-none none-none TYR APEdihe_nnnai APEdist_aaan A1L6K Type1.5_Front 575 - 863 0 None None Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 9KRYA 2.25 Inactive DFGout‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan A1L6J Type2 580 - 863 0 None None Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 9KS9A 2.8 Inactive DFGout‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan A1L6L Type2 576 - 862 0 None None Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AAXA 1.762 Inactive DFGout‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan R6H Type2 571 - 862 0 None K591R,K693R,K702R,K856R Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AW1A 1.98 Inactive DFGout‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan S4T Type2 571 - 862 0 None K591R,K693R,K702R,K856R Tyrosine-protein kinase Mer
TYR MET MET_HUMAN 3RHKA 1.94 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai M97 Type1 1049 - 1346 0 None None Hepatocyte growth factor receptor
TYR MET MET_HUMAN 3EFJA 2.6 Inactive DFGout‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan MT3 Type1.5_Front 1054 - 1351 0 None L1272L Hepatocyte growth factor receptor
TYR MET MET_HUMAN 5DG5A 2.6 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 5B4 Type2 1050 - 1346 0 None None Hepatocyte growth factor receptor
TYR MET MET_HUMAN 5DG5B 2.6 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 5B4 Type2 1050 - 1346 0 None None Hepatocyte growth factor receptor
TYR MET MET_HUMAN 7V3RA 1.7 Inactive DFGout‑None in-out out-none TYR APEdihe_nniai APEdist_aaai 5IE Type2 1053 - 1346 0 None None Hepatocyte growth factor receptor
TYR MET MET_HUMAN 3CTJA 2.5 Inactive DFGout‑None in-in none-none TYR APEdihe_nniai APEdist_aaai 320 Type2 1051 - 1360 0 None Y1194F,Y1234F,Y1235D Hepatocyte growth factor receptor
TYR MET MET_HUMAN 3C1XA 2.17 Inactive DFGout‑None in-out none-none TYR APEdihe_nniai APEdist_aaai CKK Type2 1050 - 1360 0 None Y1194F,Y1234F,Y1235D,L1272L Hepatocyte growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6D20A 1.94 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai FQD, FQG Allosteric, Type3 482 - 796 0 None None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 4F0IA 2.302 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 501 - 790 0 None None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 4F0IB 2.302 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 501 - 794 0 None None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 4GT5A 2.398 Inactive DFGout‑None in-none out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 498 - 793 0 None None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6D22A 2.46 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 502 - 794 0 None None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6DKBA 2.68 Inactive DFGout‑None out-in none-none TYR APEdihe_niiai APEdist_aaai FKY Type1 501 - 796 0 None None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5KMOA 2.67 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 6UM Type1 500 - 796 0 None None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 4PMSA 2.8 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 31X Type1.5_Back 501 - 787 0 None None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 8J5WA 2.28 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai A4U Type2 485 - 795 0 None F589L High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 8J61A 3.051 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai A0X Type2 499 - 795 0 None None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 8J63A 3.001 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai A6X Type2 500 - 796 0 None None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5WR7A 2.76 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai RCH Type2 489 - 792 0 SEP677 None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6PL1A 2.03 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai OOJ Type2 500 - 795 0 SEP677 None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6PL3A 3.0 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai OOD Type2 500 - 795 0 None None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6PMAA 2.53 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai OQS Type2 500 - 795 0 SEP677 None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6PMBA 2.81 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai OQM Type2 500 - 795 0 None None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6PMCA 2.19 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai OQJ Type2 500 - 795 0 SEP677 None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6NSPA 2.31 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai L0P Type3 500 - 795 0 None None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6NPTA 2.19 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai KWY Type3 491 - 795 0 SEP677 None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6NSSA 1.97 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai L0M Type3 485 - 795 0 None None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 6D1YA 1.93 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai FQJ Type3 481 - 796 0 None None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5KMIA 1.87 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 6UE Type3 486 - 796 0 None None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5KMJA 2.04 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai 6UF Type3 486 - 795 0 None None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5KMKA 2.24 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 6UG Type3 484 - 796 0 None None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5KMMA 2.12 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 6UJ Type3 484 - 796 0 None None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5KMLA 2.01 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 6UH Type3 474 - 796 0 None None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5KMNA 2.14 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 6UK Type3 474 - 796 0 None None High affinity nerve growth factor receptor
TYR NTRK2 NTRK2_HUMAN 4ASZA 1.7 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 527 - 822 0 None None BDNF/NT-3 growth factors receptor
TYR NTRK2 NTRK2_HUMAN 4AT5A 1.71 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai MUJ Type2 527 - 822 0 None None BDNF/NT-3 growth factors receptor
TYR NTRK3 NTRK3_HUMAN 4YMJA 2.0 Inactive DFGout‑None out-out none-in TYR APEdihe_iiiai APEdist_aaai 4EJ Type1 530 - 831 0 SEP706 None NT-3 growth factor receptor
TYR NTRK3 NTRK3_HUMAN 4YMJB 2.0 Inactive DFGout‑None out-none out-in TYR APEdihe_iiiai APEdist_aaai 4EJ Type1 530 - 834 0 SEP706 None NT-3 growth factor receptor
TYR PDGFRA PGFRA_HUMAN 8PQKA 2.0 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 554 - 973 0 None T674I Platelet-derived growth factor receptor alpha
TYR PDGFRA PGFRA_HUMAN 6A32A 1.87 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 554 - 973 0 None T674I Platelet-derived growth factor receptor alpha
TYR PDGFRA PGFRA_HUMAN 8PQJA 1.82 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 553 - 973 0 None None Platelet-derived growth factor receptor alpha
TYR PDGFRA PGFRA_HUMAN 5K5XA 2.168 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 554 - 973 0 None None Platelet-derived growth factor receptor alpha
TYR PDGFRA PGFRA_HUMAN 6JOKA 3.8 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai B49 Type1 556 - 973 0 None None Platelet-derived growth factor receptor alpha
TYR PTK2 FAK1_HUMAN 4EBVA 1.67 Inactive DFGout‑None in-in none-out TYR APEdihe_niiai APEdist_aaao 0O7 Type1 411 - 686 0 None None Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 4K9YA 2.0 Inactive DFGout‑None in-in out-out TYR APEdihe_oiiai APEdist_aaao K9Y Type2 415 - 685 0 None None Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 4I4FA 1.75 Inactive DFGout‑None out-out none-out TYR APEdihe_niiai APEdist_aaao 1BR Type3 415 - 686 0 None None Focal adhesion kinase 1
TYR PTK2B FAK2_HUMAN 3FZPA 2.1 Inactive DFGout‑None in-out none-in TYR APEdihe_iiiai APEdist_aaai AGS ATPlike 419 - 692 0 None None Protein-tyrosine kinase 2-beta
TYR PTK2B FAK2_HUMAN 3ET7A 2.7 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai 349 Type1 419 - 691 0 None None Protein-tyrosine kinase 2-beta
TYR PTK2B FAK2_HUMAN 3FZRA 2.7 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai 3JZ Type1 419 - 691 0 None None Protein-tyrosine kinase 2-beta
TYR PTK2B FAK2_HUMAN 5TO8A 1.985 Inactive DFGout‑None in-none out-none TYR APEdihe_nnnan APEdist_aaan 7FM Type1 420 - 691 0 None None Protein-tyrosine kinase 2-beta
TYR PTK2B FAK2_HUMAN 3FZTA 1.95 Inactive DFGout‑None in-in out-none TYR APEdihe_nniai APEdist_aaai 4JZ Type2 420 - 690 0 None None Protein-tyrosine kinase 2-beta
TYR PTK2B FAK2_HUMAN 4H1JA 2.0 Inactive DFGout‑None in-in out-out TYR APEdihe_oiiai APEdist_aaai 0YH Type2 419 - 690 0 None None Protein-tyrosine kinase 2-beta
TYR ROR2 ROR2_HUMAN 3ZZWB 2.9 Pseudo DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 466 - 750 0 None None Tyrosine-protein kinase transmembrane receptor ROR2
TYR SYK KSYK_HUMAN 3TUDA 2.33 Inactive DFGout‑None in-in none-in TYR APEdihe_iiiai APEdist_aaai FPX Type2 363 - 635 0 None None Tyrosine-protein kinase SYK
TYR TEK TIE2_HUMAN 2WQBA 2.95 Inactive DFGout‑None none-none out-out TYR APEdihe_iiiai APEdist_aaao QQ1 Type1 816 - 1120 0 None D964N Angiopoietin-1 receptor
TYR TEK TIE2_HUMAN 2P4IB 2.5 Inactive DFGout‑None in-in none-out TYR APEdihe_iiiai APEdist_aaao MR9 Type2 836 - 1117 0 None None Angiopoietin-1 receptor
TYR TEK TIE2_HUMAN 4X3JA 2.5 Inactive DFGout‑None in-out none-out TYR APEdihe_nniai APEdist_aaao 3WR Type2 838 - 1117 0 None D964N Angiopoietin-1 receptor
TYR TNK2 ACK1_HUMAN 5ZXBA 2.198 Inactive DFGout‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan 9KO Type2 117 - 389 0 None None Activated CDC42 kinase 1
TYR TNK2 ACK1_HUMAN 5ZXBB 2.198 Inactive DFGout‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan 9KO Type2 117 - 389 0 None None Activated CDC42 kinase 1

All / DFGoutNone / All

Total number of chains: 368
Active chains: 0
Total number of genes: 82
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 368 100.0% 4I93A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
OTHER BSK8 BSK8_ARATH 4I94A 1.8 Pseudo DFGout‑None out-out out-out nonTYR APEdihe_aaiai APEdist_iioo ANP ATPlike 40 - 328 0 None None Serine/threonine-protein kinase BSK8 Arabidopsis thaliana
OTHER BSK8 BSK8_ARATH 4I94B 1.8 Pseudo DFGout‑None out-out out-out nonTYR APEdihe_aaiai APEdist_iioo ANP ATPlike 40 - 328 0 None None Serine/threonine-protein kinase BSK8 Arabidopsis thaliana
OTHER BSK8 BSK8_ARATH 4I92A 1.6 Pseudo DFGout‑None out-out out-out nonTYR APEdihe_aaiai APEdist_iooo No_ligand No_ligand 40 - 328 0 None None Serine/threonine-protein kinase BSK8 Arabidopsis thaliana
OTHER BSK8 BSK8_ARATH 4I93A 1.5 Pseudo DFGout‑None out-out out-out nonTYR APEdihe_aaiai APEdist_iioo No_ligand No_ligand 40 - 328 0 None None Serine/threonine-protein kinase BSK8 Arabidopsis thaliana
OTHER BSK8 BSK8_ARATH 4I93B 1.5 Pseudo DFGout‑None out-out out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 40 - 328 0 None None Serine/threonine-protein kinase BSK8 Arabidopsis thaliana
TKL CTR1 CTR1_ARATH 3P86A 2.496 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno STU Type1 544 - 810 0 None D676N Serine/threonine-protein kinase CTR1 Arabidopsis thaliana
TYR SRC SRC_CHICK 3D7TB 2.899 Inactive DFGout‑None in-in out-none TYR APEdihe_niiai APEdist_aaai STU Type1 258 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 5K9IB 2.5 Inactive DFGout‑None out-out in-none TYR APEdihe_nniai APEdist_aaai O44 Type1 259 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 7D5OB 2.69 Inactive DFGout‑None out-out none-out TYR APEdihe_nniai APEdist_aaao TZ0 Type1 258 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3EL7A 2.8 Inactive DFGout‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan PD3 Type2 257 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3EL8A 2.3 Inactive DFGout‑None in-in in-out TYR APEdihe_nnoai APEdist_aaao PD5 Type2 258 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3G6GB 2.31 Inactive DFGout‑None in-in none-out TYR APEdihe_iioai APEdist_aaao G6G Type2 256 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 4AGWA 2.6 Inactive DFGout‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan NG7 Type2 257 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 4AGWB 2.6 Inactive DFGout‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan NG7 Type2 258 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3TZ9B 3.1 Inactive DFGout‑None in-in none-out TYR APEdihe_nnoai APEdist_aaao AQU Type2 257 - 533 0 None S345C Proto-oncogene tyrosine-protein kinase Src Gallus gallus
AGC AKT1 AKT1_HUMAN 5KCVA 2.7 Inactive DFGout‑None none-none none-none nonTYR APEdihe_aannn APEdist_nnnn 6S1 Allosteric 6 - 438 0 None E114A,E115A,E116A RAC-alpha serine/threonine-protein kinase Homo sapiens
AGC AKT1 AKT1_HUMAN 7APJA 2.05 Inactive DFGout‑None none-none none-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 3 - 439 0 None S2N RAC-alpha serine/threonine-protein kinase Homo sapiens
AGC AKT2 AKT2_HUMAN 1GZKA 2.3 Inactive DFGout‑None in-none none-out nonTYR APEdihe_aanoo APEdist_nnnn No_ligand No_ligand 146 - 441 0 None None RAC-beta serine/threonine-protein kinase Homo sapiens
AGC AKT2 AKT2_HUMAN 1GZOA 2.75 Inactive DFGout‑None in-none none-out nonTYR APEdihe_aanoo APEdist_nnnn No_ligand No_ligand 146 - 442 0 None None RAC-beta serine/threonine-protein kinase Homo sapiens
AGC AKT2 AKT2_HUMAN 1GZNA 2.5 Inactive DFGout‑None in-none none-out nonTYR APEdihe_aanoo APEdist_nnnn No_ligand No_ligand 146 - 442 0 None None RAC-beta serine/threonine-protein kinase Homo sapiens
AGC AKT2 AKT2_HUMAN 1MRVA 2.8 Inactive DFGout‑None none-none none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 147 - 440 0 None None RAC-beta serine/threonine-protein kinase Homo sapiens
AGC AKT2 AKT2_HUMAN 1MRYA 2.8 Inactive DFGout‑None none-none none-out nonTYR APEdihe_aaioo APEdist_nnio No_ligand No_ligand 146 - 440 0 None None RAC-beta serine/threonine-protein kinase Homo sapiens
AGC PDPK1 PDPK1_HUMAN 3QC4B 1.8 Inactive DFGout‑None out-out in-in nonTYR APEdihe_aaiii APEdist_iiii MP7 Type2 51 - 359 0 SEP241 E303A,K304A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC ROCK1 ROCK1_HUMAN 7S25A 2.337 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaiii APEdist_nnno 86G Type1 7 - 401 0 None None Rho-associated protein kinase 1 Homo sapiens
AGC ROCK1 ROCK1_HUMAN 7S25B 2.337 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaiii APEdist_iioo 86G Type1 8 - 402 0 None None Rho-associated protein kinase 1 Homo sapiens
AGC ROCK1 ROCK1_HUMAN 7S25C 2.337 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn 86G Type1 13 - 402 0 None None Rho-associated protein kinase 1 Homo sapiens
AGC ROCK2 ROCK2_HUMAN 9JCUB 3.02 Inactive DFGout‑None out-out in-out nonTYR APEdihe_aaioi APEdist_iooi No_ligand No_ligand 27 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
AGC ROCK2 ROCK2_HUMAN 9JCUD 3.02 Inactive DFGout‑None out-out in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 27 - 417 0 None None Rho-associated protein kinase 2 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 8EQ5A 1.8 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_iioo QCT Type1 49 - 346 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 8R58A 2.31 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_nioo QCT Type1 49 - 348 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYA 3.2 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nooo A1LU8 Type1 58 - 358 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYB 3.2 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nooo A1LU8 Type1 59 - 358 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYC 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_nooo A1LU8 Type1 61 - 358 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYD 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nooo A1LU8 Type1 63 - 348 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYE 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nooi A1LU8 Type1 64 - 348 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYF 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nooo A1LU8 Type1 63 - 345 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYG 3.2 Inactive DFGout‑None in-out out-out nonTYR APEdihe_aaiii APEdist_nooi A1LU8 Type1 59 - 346 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYH 3.2 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nooi A1LU8 Type1 59 - 348 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYI 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaioi APEdist_nooo A1LU8 Type1 63 - 348 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 8XFYJ 3.2 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_nooi A1LU8 Type1 65 - 347 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 4NUSA 2.39 Inactive DFGout‑None in-out out-out nonTYR APEdihe_aaiii APEdist_iooi 2NK Type1 53 - 359 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 5D9LA 2.15 Inactive DFGout‑None in-out out-out nonTYR APEdihe_aaiii APEdist_nnno 583 Type1 49 - 359 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 5D9KA 2.55 Inactive DFGout‑None in-out out-out nonTYR APEdihe_aaiii APEdist_nnoi 584 Type1 62 - 359 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 5D9KB 2.55 Inactive DFGout‑None in-none out-out nonTYR APEdihe_aaiii APEdist_nnoi 584 Type1 62 - 359 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC SGK1 SGK1_HUMAN 7PUEA 2.506 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaioo APEdist_oooo 86H Type1 82 - 376 0 None R192A,S422D Serine/threonine-protein kinase Sgk1 Homo sapiens
CAMK AURKA AURKA_HUMAN 6VPJA 2.1 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaooi APEdist_iioo ANP ATPlike 104 - 389 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 6VPHA 2.14 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo ANP ATPlike 7 - 389 0 TPO287,TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 4JAIA 3.2 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aanno APEdist_nnnn XU2 Type1 126 - 390 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 7AYHA 2.8 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn S9H Type1 125 - 390 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 7O2VA 3.1 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo V0K Type1 117 - 390 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3O51A 3.2 Inactive DFGout‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn LJF Type1.5_Front 126 - 388 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 6HJKA 2.4 Inactive DFGout‑None out-none out-out nonTYR APEdihe_aaoii APEdist_nnoo G7W Type1.5_Front 127 - 391 0 None L210C,C290A,C393A Aurora kinase A Homo sapiens
CAMK MELK MELK_HUMAN 5K00A 1.77 Inactive DFGout‑None out-in out-none nonTYR APEdihe_aanii APEdist_nnnn 6PV Type2 3 - 327 0 None None Maternal embryonic leucine zipper kinase Homo sapiens
CAMK MKNK1 MKNK1_HUMAN 5WVDA 3.0 Inactive DFGout‑None in-out out-none nonTYR APEdihe_aannn APEdist_nnnn 7UX Type1 41 - 375 0 None None MAP kinase-interacting serine/threonine-protein kinase 1 Homo sapiens
CAMK MKNK1 MKNK1_HUMAN 5WVDB 3.0 Inactive DFGout‑None in-out out-none nonTYR APEdihe_aannn APEdist_nnnn 7UX Type1 41 - 374 0 None None MAP kinase-interacting serine/threonine-protein kinase 1 Homo sapiens
CAMK MKNK2 MKNK2_HUMAN 6JLRA 2.901 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaioi APEdist_nnno BV9 Type1 72 - 369 0 None None MAP kinase-interacting serine/threonine-protein kinase 2 Homo sapiens
CMGC CDK16 CDK16_HUMAN 3MTLA 2.4 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn FEF Type1 163 - 473 0 None S319D Cyclin-dependent kinase 16 Homo sapiens
CMGC CDK16 CDK16_HUMAN 5G6VB 2.2 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaoii APEdist_nnno 919 Type2 163 - 475 0 None S319D Cyclin-dependent kinase 16 Homo sapiens
CMGC CDK2 CDK2_HUMAN 5A14A 2.0 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaioi APEdist_nnno LQ5, LQ5 Type2, Allosteric 1 - 296 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CLK3 CLK3_HUMAN 9EZ3A 2.7 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aaiii APEdist_nnni A1H74 Type2 136 - 481 0 None None Dual specificity protein kinase CLK3 Homo sapiens
CMGC MAPK11 MK11_HUMAN 8YGWA 3.301 Inactive DFGout‑None in-out none-out nonTYR APEdihe_aaoii APEdist_nnno B96 Type2 5 - 348 0 None None Mitogen-activated protein kinase 11 Homo sapiens
CMGC MAPK13 MK13_HUMAN 5EKNA 2.594 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaioi APEdist_nnno N58 Type2 2 - 351 0 None None Mitogen-activated protein kinase 13 Homo sapiens
CMGC MAPK14 MK14_HUMAN 5N64A 2.4 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno 8OH Allosteric 5 - 354 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 5N66A 2.4 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno BW1, B96 Allosteric, Type2 6 - 353 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 4EH8A 2.2 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno IRG, 0OP, 0OP Allosteric, Type3, Type1 4 - 354 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 2FSMX 1.86 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaiii APEdist_nnno No_ligand No_ligand 4 - 352 0 None D176A,F327S Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 2NPQA 1.8 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaiii APEdist_nnno No_ligand No_ligand 4 - 351 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 4GEOA 1.66 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aanii APEdist_nnnn No_ligand No_ligand 5 - 351 0 None M194A,L195A,H228A,I229A,Y258A Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3MH3A 2.2 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno No_ligand No_ligand 5 - 352 0 None F169R Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3MH1A 2.2 Inactive DFGout‑None in-out none-out nonTYR APEdihe_aaoii APEdist_nnoo No_ligand No_ligand 5 - 352 0 None F169G Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3IW5A 2.5 Inactive DFGout‑None in-out none-out nonTYR APEdihe_aaooi APEdist_nnno DF3 Type1 4 - 353 0 None C119S,C162S,A172C,F327L Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3L8SA 2.35 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno BFF Type1 4 - 353 0 None C119S,C162S,A172C,F327L Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 6SFKA 1.8 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnoo LB8 Type2 4 - 353 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3HECA 2.5 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno STI Type2 5 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3NNUA 2.4 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaooi APEdist_oooo EDB Type2 5 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3NNWA 1.89 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaooi APEdist_oooo EDD Type2 4 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 1KV2A 2.8 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aanii APEdist_nnnn B96 Type2 5 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 1WBSA 1.8 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaoii APEdist_oooo LI2 Type2 4 - 355 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 1WBTA 2.0 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaoii APEdist_oooo WBT Type2 4 - 355 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 9CJ1A 1.8 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno NIL Type2 5 - 351 0 TPO180,PTR182 None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3UVRA 2.1 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno 06F Type2 5 - 351 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 4L8MA 2.1 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaooi APEdist_nnoo F46 Type2 5 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3BV3A 2.59 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nioo P39 Type2 5 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 2YISA 2.0 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno YIS, I46 Type2, Allosteric 5 - 353 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 2YIWA 2.0 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno YIW, I46 Type2, Allosteric 5 - 353 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 9CJ5A 3.3 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nooo A1AWV, PDO Type2, Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3K3JA 1.995 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno F4C, I46 Type2, Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3LFDA 3.4 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno Z85 Type3 4 - 353 0 None C119S,C162S,A172C,F327L Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 1KV1A 2.5 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno BMU Type3 5 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3O8TA 2.0 Inactive DFGout‑None in-out none-out nonTYR APEdihe_aaooi APEdist_nnno BMU Type3 5 - 352 0 None F169A Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3OC1A 2.59 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno BMU Type3 5 - 352 0 None F169G Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK6 MK06_HUMAN 6YLCA 2.43 Inactive DFGout‑None in-out out-out nonTYR APEdihe_aaiii APEdist_oooo OXW Type1 15 - 320 0 None L290V Mitogen-activated protein kinase 6 Homo sapiens
CMGC MAPK9 MK09_HUMAN 3NPCA 2.35 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaoii APEdist_oioo B96 Type2 7 - 363 0 None D3K,C6V,S8N,Q14E,K203A,E204A,K250A,K251A Mitogen-activated protein kinase 9 Homo sapiens
CMGC MAPK9 MK09_HUMAN 3NPCB 2.35 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaoii APEdist_oioo B96 Type2 8 - 363 0 None D3K,C6V,S8N,Q14E,K203A,E204A,K250A,K251A Mitogen-activated protein kinase 9 Homo sapiens
CMGC PRP4K PRP4K_HUMAN 6CNHA 2.0 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno 919 Type2 657 - 1005 0 None None Serine/threonine-protein kinase PRP4 homolog Homo sapiens
NEK NEK2 NEK2_HUMAN 2XK3A 2.2 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno XK3 Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK NEK2 NEK2_HUMAN 2XK4A 2.1 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nooo OL2 Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK NEK2 NEK2_HUMAN 2XK8A 2.001 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno 5R1 Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK NEK2 NEK2_HUMAN 2XNPA 1.98 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nooo WCX Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK NEK2 NEK2_HUMAN 4AFEA 2.597 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaioo APEdist_nnoo GGY Type1 3 - 271 0 None None Serine/threonine-protein kinase Nek2 Homo sapiens
NEK NEK2 NEK2_HUMAN 4A4XA 2.4 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnoo JUP Type1 3 - 271 0 None T170E,S171D,T175E Serine/threonine-protein kinase Nek2 Homo sapiens
NEK NEK7 NEK7_HUMAN 5DE2A 2.78 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaooo APEdist_nnno No_ligand No_ligand 20 - 300 0 None Y97F Serine/threonine-protein kinase Nek7 Homo sapiens
NEK NEK7 NEK7_HUMAN 6S75D 3.3 Inactive DFGout‑None out-none none-out nonTYR APEdihe_aanoo APEdist_nnnn No_ligand No_ligand 28 - 299 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK NEK7 NEK7_HUMAN 8WS0A 2.12 Inactive DFGout‑None out-out out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 20 - 300 0 None S195D Serine/threonine-protein kinase Nek7 Homo sapiens
NEK NEK7 NEK7_HUMAN 8SXNA 4.04 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aaioo APEdist_oiio No_ligand No_ligand 19 - 302 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK NEK7 NEK7_HUMAN 8SXNB 4.04 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aaioo APEdist_oiio No_ligand No_ligand 19 - 302 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
NEK NEK7 NEK7_HUMAN 8WS1A 2.4 Inactive DFGout‑None out-out out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 20 - 300 0 None D161N Serine/threonine-protein kinase Nek7 Homo sapiens
NEK NEK7 NEK7_HUMAN 6S75A 3.3 Inactive DFGout‑None out-none none-out nonTYR APEdihe_aanio APEdist_nnnn F9N Type1 19 - 300 0 None None Serine/threonine-protein kinase Nek7 Homo sapiens
OTHER EIF2AK3 E2AK3_HUMAN 4X7HA 2.0 Inactive DFGout‑None out-out none-none nonTYR APEdihe_aanii APEdist_nnnn 3Z2 Type2 585 - 1086 0 None D937N Eukaryotic translation initiation factor 2-alpha kinase 3 Homo sapiens
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKA 2.3 Inactive DFGout‑None out-none none-out nonTYR APEdihe_aaoni APEdist_nnno G41 Type1 583 - 998 0 None D848N eIF-2-alpha kinase GCN2 Homo sapiens
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKB 2.3 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaoni APEdist_nnno G41 Type1 583 - 998 0 None D848N eIF-2-alpha kinase GCN2 Homo sapiens
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKC 2.3 Inactive DFGout‑None out-out out-none nonTYR APEdihe_aanni APEdist_nnnn G41 Type1 583 - 1004 0 None D848N eIF-2-alpha kinase GCN2 Homo sapiens
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKD 2.3 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaoni APEdist_nnno G41 Type1 583 - 1003 0 None D848N eIF-2-alpha kinase GCN2 Homo sapiens
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKE 2.3 Inactive DFGout‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn G41 Type1 584 - 1004 0 None D848N eIF-2-alpha kinase GCN2 Homo sapiens
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKG 2.3 Inactive DFGout‑None out-out out-none nonTYR APEdihe_aanni APEdist_nnnn G41 Type1 584 - 1007 0 None D848N eIF-2-alpha kinase GCN2 Homo sapiens
OTHER EIF2AK4-2 E2AK4_HUMAN 6N3LA 2.61 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aanni APEdist_nnnn KAV Type2 584 - 1002 0 None K807A,D848N,T899A,T904A eIF-2-alpha kinase GCN2 Homo sapiens
OTHER EIF2AK4-2 E2AK4_HUMAN 6N3LB 2.61 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aanni APEdist_nnnn KAV Type2 584 - 1002 0 None K807A,D848N,T899A,T904A eIF-2-alpha kinase GCN2 Homo sapiens
OTHER ERN1 ERN1_HUMAN 4YZ9A 2.463 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnno 4K7 Type3 562 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
OTHER ERN1 ERN1_HUMAN 4YZ9B 2.463 Inactive DFGout‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn 4K7 Type3 563 - 963 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
OTHER ERN1 ERN1_HUMAN 4YZ9C 2.463 Inactive DFGout‑None out-out none-none nonTYR APEdihe_aanii APEdist_nnnn 4K7 Type3 562 - 964 0 None None Serine/threonine-protein kinase/endoribonuclease IRE1 Homo sapiens
OTHER MLKL MLKL_HUMAN 6O5ZB 2.285 Pseudo DFGout‑None in-out none-out nonTYR APEdihe_aaoii APEdist_nnno LN4 Type2 190 - 467 0 None None Mixed lineage kinase domain-like protein Homo sapiens
STE MAP2K1 MP2K1_HUMAN 5HZEA 2.4 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaioi APEdist_oooo E62 Type1 43 - 382 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 8YP4B 2.35 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aanoo APEdist_nnnn WNT Type1 43 - 383 0 None T286A,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K6 MP2K6_HUMAN 8P7JA 2.4 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aannn APEdist_nnnn X3K Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
STE MAP2K6 MP2K6_HUMAN 8P7JB 2.4 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aanao APEdist_nnnn X3K Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
STE MAP2K6 MP2K6_HUMAN 8PM3A 2.0 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aanao APEdist_nnnn ZLE Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
STE MAP2K6 MP2K6_HUMAN 8PM3B 2.0 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aanao APEdist_nnnn ZLE Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
STE MAP2K6 MP2K6_HUMAN 8PM3C 2.0 Inactive DFGout‑None out-na out-out nonTYR APEdihe_aanao APEdist_nnnn ZLE Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
STE MAP2K6 MP2K6_HUMAN 8PM3D 2.0 Inactive DFGout‑None out-na out-none nonTYR APEdihe_aannn APEdist_nnnn ZLE Type1 47 - 333 0 None S207D,T211D Dual specificity mitogen-activated protein kinase kinase 6 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6YZ4A 1.7 Inactive DFGout‑None in-na out-out nonTYR APEdihe_aaoai APEdist_nnno 1E8 Allosteric 101 - 404 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 5Y8UA 2.92 Inactive DFGout‑None out-na none-out nonTYR APEdihe_aaiao APEdist_nnoo No_ligand No_ligand 103 - 402 0 None C260S Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 5Y90A 1.3 Inactive DFGout‑None in-na out-out nonTYR APEdihe_aaiai APEdist_nnoi No_ligand No_ligand 103 - 419 0 None C202S Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 5B2LA 2.1 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aaiai APEdist_nnni No_ligand No_ligand 104 - 403 0 None C202S Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6YFZA 1.9 Inactive DFGout‑None in-na out-out nonTYR APEdihe_aaoai APEdist_nnno No_ligand No_ligand 100 - 405 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6QFRA 2.3 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 102 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 5B2KA 2.75 Inactive DFGout‑None out-na none-out nonTYR APEdihe_aaoai APEdist_nnno No_ligand No_ligand 104 - 400 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6YG0A 2.0 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 102 - 402 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 7CBXA 2.061 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aanai APEdist_nnnn FU6 Type1 103 - 402 0 None C202S Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 5Z1EA 2.3 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aaiai APEdist_nnni 95U Type1 103 - 419 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6YG4A 2.3 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aannn APEdist_nnnn SU9 Type1 103 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6YG5A 2.4 Inactive DFGout‑None in-na out-none nonTYR APEdihe_aannn APEdist_nnnn IHH Type1 101 - 403 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 3WZUA 3.01 Inactive DFGout‑None none-na none-out nonTYR APEdihe_aaoai APEdist_nnno 1FM Type1 104 - 402 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6YG6A 2.15 Inactive DFGout‑None out-na none-out nonTYR APEdihe_aaiao APEdist_nnno OQ8 Type2 103 - 403 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6YG6B 2.15 Inactive DFGout‑None out-na none-out nonTYR APEdihe_aaiao APEdist_nnno OQ8 Type2 104 - 403 0 None S271D,T275D Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP3K2 M3K2_HUMAN 9P6AB 2.4 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaioi APEdist_nnoo 0LI Type2 347 - 618 0 None None Mitogen-activated protein kinase kinase kinase 2 Homo sapiens
STE MAP3K5 M3K5_HUMAN 8QGYA 3.71 Inactive DFGout‑None in-out in-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 95 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9N7RA 2.13 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo A1BWC, A1BWC, A1BWC, A1BWC Allosteric, Allosteric, Type1, Type3 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8PAUA 2.8 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiii APEdist_nnno XOR Type1 7 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8PAUB 2.8 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiii APEdist_nnno XOR Type1 7 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8PASA 2.7 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn XOH Type1 8 - 295 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8PASB 2.7 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn XOH Type1 7 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8CDWA 1.941 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno UES Type1 7 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8CIJA 2.821 Inactive DFGout‑None out-out none-none nonTYR APEdihe_aaiii APEdist_nnni USF Type1 14 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8PARA 2.0 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno XON Type1 7 - 294 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4U3ZB 2.09 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 14 - 311 0 None T181E Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4ZP5B 2.29 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 10 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 5DI1B 2.9 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 10 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 5J95B 2.5 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 10 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 8V5IB 2.18 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 16 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4RVTB 2.4 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4OBOB 2.1 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 12 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4OBPB 2.27 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 14 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4OBQB 2.19 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4U40B 2.3 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4U41B 2.2 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 12 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4U43B 2.18 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 10 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4U44B 2.43 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 14 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4U45B 2.58 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4ZK5B 2.89 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 5W5QB 2.33 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 13 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE PAK1 PAK1_HUMAN 4ZLOA 2.5 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaioo APEdist_nnno 4PV Type3 250 - 543 0 TPO423 None Serine/threonine-protein kinase PAK 1 Homo sapiens
STE PAK2 PAK2_HUMAN 9M41B 3.02 Inactive DFGout‑None out-none out-out nonTYR APEdihe_aaiio APEdist_nnno No_ligand No_ligand 83 - 521 0 None K278R,D368N Serine/threonine-protein kinase PAK 2 Homo sapiens
STE STK10 STK10_HUMAN 4AOTA 2.33 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaiio APEdist_nnno GW8 Type1 18 - 314 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 4AOTB 2.33 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaiio APEdist_nnoo GW8 Type1 18 - 314 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 4USDA 3.05 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno R09 Type1 24 - 314 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 4USDB 3.05 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaiio APEdist_nnno R09 Type1 24 - 314 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 4EQUA 2.0 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaiii APEdist_nnoo G6I Type2 24 - 317 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 4EQUB 2.0 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaiii APEdist_nooo G6I Type2 24 - 317 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 6I2YA 2.56 Inactive DFGout‑None out-out in-out nonTYR APEdihe_aaiii APEdist_nnoo 88Z Type2 24 - 317 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK10 STK10_HUMAN 6I2YB 2.56 Inactive DFGout‑None out-none out-out nonTYR APEdihe_aaini APEdist_nnoo 88Z Type2 24 - 317 0 None None Serine/threonine-protein kinase 10 Homo sapiens
STE STK26 STK26_HUMAN 4FZAB 3.15 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo No_ligand No_ligand 18 - 297 0 None D162A Serine/threonine-protein kinase 26 Homo sapiens
STE STK26 STK26_HUMAN 4FZDB 3.25 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iooo No_ligand No_ligand 18 - 297 0 None D162A Serine/threonine-protein kinase 26 Homo sapiens
TKL BRAF BRAF_HUMAN 4RZWA 3.493 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaiii APEdist_nnno B1E Type1 448 - 720 0 None R509H,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 3C4CB 2.57 Inactive DFGout‑None in-out none-out nonTYR APEdihe_aaiii APEdist_nnno 324 Type1.5_Back 448 - 721 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 4RZWB 3.493 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaiii APEdist_nnno B1E Type2 448 - 721 0 None R509H,I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 6CADB 2.55 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno EU4 Type2 449 - 721 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 6NSQB 3.05 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno KZP Type2 447 - 722 0 None I543A,I544S,I551K,Q562R,L588N,K630S,F667E,Y673S,A688R,L706S,Q709R,S713E,L716E,S720E,P722S,K723G Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 8QQGA 2.979 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaiii APEdist_nnno WJ9 Type2 449 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 5CT7B 3.17 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 55J Type2 449 - 721 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL IRAK4 IRAK4_HUMAN 6EG9A 2.414 Inactive DFGout‑None in-out none-none nonTYR APEdihe_aaiii APEdist_nnni 0LI Type2 164 - 459 0 None None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 6EG9B 2.414 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aaiii APEdist_nnni 0LI Type2 165 - 459 0 None None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 6EGAA 2.512 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoio APEdist_nnni J8A Type2 166 - 459 0 None None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 6EGAB 2.512 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aaiii APEdist_nnni J8A Type2 164 - 459 0 None None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL LIMK2 LIMK2_HUMAN 5NXDA 1.9 Inactive DFGout‑None out-out out-none nonTYR APEdihe_aannn APEdist_nnnn 9D8 Type3 330 - 632 0 None None LIM domain kinase 2 Homo sapiens
TKL LRRK1 LRRK1_HUMAN 8E04A 3.8 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 381 - 2007 0 None None Leucine-rich repeat serine/threonine-protein kinase 1 Homo sapiens
TKL LRRK1 LRRK1_HUMAN 8E05A 4.6 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 51 - 2007 0 None None Leucine-rich repeat serine/threonine-protein kinase 1 Homo sapiens
TKL LRRK1 LRRK1_HUMAN 8E05B 4.6 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 51 - 2007 0 None None Leucine-rich repeat serine/threonine-protein kinase 1 Homo sapiens
TKL LRRK1 LRRK1_HUMAN 8E06A 4.3 Inactive DFGout‑None in-out none-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 51 - 2007 0 None None Leucine-rich repeat serine/threonine-protein kinase 1 Homo sapiens
TKL LRRK1 LRRK1_HUMAN 8FACA 3.92 Inactive DFGout‑None in-out out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 341 - 2013 0 None None Leucine-rich repeat serine/threonine-protein kinase 1 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 8FO9E 3.48 Inactive DFGout‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 9DMIA 3.35 Inactive DFGout‑None in-out none-out nonTYR APEdihe_aaioi APEdist_nnoi A1A7Q Type2 1334 - 2526 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 8TZEA 2.9 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn T3X Type2 1624 - 2522 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 8TZFA 3.4 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn T3X Type2 587 - 2522 0 None I2020T Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL MAP3K7 M3K7_HUMAN 5J9LA 2.752 Inactive DFGout‑None in-out none-out nonTYR APEdihe_aaoii APEdist_nnno 6HF Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
TKL MAP3K7 M3K7_HUMAN 5J7SA 2.368 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaoii APEdist_nnno 6H3 Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
TKL MAP3K7 M3K7_HUMAN 5GJFA 2.89 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaooi APEdist_iiio 6V4 Type2 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
TKL RIPK2 RIPK2_HUMAN 4C8BA 2.75 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoni APEdist_nnno 0LI Type2 8 - 316 0 None None Receptor-interacting serine/threonine-protein kinase 2 Homo sapiens
TKL RIPK2 RIPK2_HUMAN 4C8BB 2.75 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno 0LI Type2 9 - 316 0 None None Receptor-interacting serine/threonine-protein kinase 2 Homo sapiens
TKL RIPK2 RIPK2_HUMAN 5AR7A 2.71 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn SR8 Type2 6 - 310 0 None None Receptor-interacting serine/threonine-protein kinase 2 Homo sapiens
TYR ABL1 ABL1_HUMAN 2G2FB 2.7 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai AGS ATPlike 234 - 502 0 None H396P Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 6XR7A 999.0 Inactive DFGout‑None in-in out-out TYR APEdihe_ooiai APEdist_aaai No_ligand No_ligand 229 - 515 0 None None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 8I7TB 2.8 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai 6I5 Type1 232 - 500 0 PTR393 None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 2HZIA 1.7 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai JIN Type1 233 - 500 0 None None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 4ZOGB 2.3 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai VX6 Type1 234 - 503 0 None None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 4WA9B 2.2 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai AXI Type1 246 - 508 0 None None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 3UE4A 2.424 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai DB8 Type1 233 - 502 0 None None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 3UE4B 2.424 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai DB8 Type1 233 - 502 0 None None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 8I7TA 2.8 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai 6I5 Type1.5_Back 232 - 500 0 PTR393 None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 2HZIB 1.7 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai JIN Type1.5_Back 233 - 500 0 None None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 2G2HB 2.0 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai P16 Type1.5_Back 233 - 504 0 None H396P Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 2FO0A 2.27 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai P16 Type1.5_Back 46 - 511 0 SEP50 D363N Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 1OPLA 3.42 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai P16 Type1.5_Back 62 - 512 0 None K12R,D363N Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 1OPLB 3.42 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai P16 Type1.5_Back 121 - 499 0 None K12R,D363N Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 5MO4A 2.17 Inactive DFGout‑None in-in none-out TYR APEdihe_nnoai APEdist_aaao NIL, AY7 Type2, Allosteric 64 - 512 0 None None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ALK ALK_HUMAN 4FNYA 2.45 Inactive DFGout‑None in-in none-out TYR APEdihe_oiiai APEdist_aaao I3K Type2 1103 - 1404 0 None C1097S,R1275Q ALK tyrosine kinase receptor Homo sapiens
TYR CSF1R CSF1R_HUMAN 2OGVA 2.7 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 543 - 918 0 None None Macrophage colony-stimulating factor 1 receptor Homo sapiens
TYR DDR1 DDR1_HUMAN 5BVWA 1.94 Inactive DFGout‑None in-in none-in TYR APEdihe_iiiai APEdist_aaai 1N1 Type1 604 - 911 0 None None Epithelial discoidin domain-containing receptor 1 Homo sapiens
TYR DDR1 DDR1_HUMAN 5SB2A 1.6 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai 1K2 Type2 603 - 912 0 None None Epithelial discoidin domain-containing receptor 1 Homo sapiens
TYR DDR1 DDR1_HUMAN 5BVKA 2.29 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai 4VC Type3 604 - 911 0 None None Epithelial discoidin domain-containing receptor 1 Homo sapiens
TYR EGFR EGFR_HUMAN 4I1ZA 3.0 Inactive DFGout‑None out-out in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 701 - 987 0 None T790M,L858R,V948R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 4I21A 3.37 Inactive DFGout‑None out-out in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 703 - 1019 0 None T790M,L858R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 4I21B 3.37 Inactive DFGout‑None out-out in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 703 - 1020 0 None T790M,L858R Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 2RF9B 3.5 Inactive DFGout‑None out-none in-out TYR APEdihe_ioiai APEdist_aaao No_ligand No_ligand 701 - 985 0 None None Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 4I20A 3.34 Inactive DFGout‑None out-out in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 701 - 987 0 None L858R,V948R Epidermal growth factor receptor Homo sapiens
TYR EPHA2 EPHA2_HUMAN 5IA4A 1.797 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 88Z Type2 605 - 877 0 None None Ephrin type-A receptor 2 Homo sapiens
TYR EPHA2 EPHA2_HUMAN 5IA5A 1.776 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai GV0 Type2 605 - 880 0 None None Ephrin type-A receptor 2 Homo sapiens
TYR EPHA2 EPHA2_HUMAN 6Q7FA 1.204 Inactive DFGout‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan HNZ Type2 605 - 896 0 None None Ephrin type-A receptor 2 Homo sapiens
TYR EPHA2 EPHA2_HUMAN 8BOFA 1.82 Inactive DFGout‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan R3L Type2 605 - 896 0 None None Ephrin type-A receptor 2 Homo sapiens
TYR EPHA3 EPHA3_HUMAN 4P5ZA 2.002 Inactive DFGout‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan Q7M Type2 609 - 903 0 None None Ephrin type-A receptor 3 Homo sapiens
TYR EPHA3 EPHA3_HUMAN 4TWNA 1.706 Inactive DFGout‑None in-in out-none TYR APEdihe_niiai APEdist_aaai B96 Type2 609 - 904 0 None None Ephrin type-A receptor 3 Homo sapiens
TYR ERBB2 ERBB2_HUMAN 8U8XA 1.69 Inactive DFGout‑None out-out out-out TYR APEdihe_iiiai APEdist_aaao W9N Type1 712 - 1024 0 None None Receptor tyrosine-protein kinase erbB-2 Homo sapiens
TYR FGFR1 FGFR1_HUMAN 4V01A 2.33 Inactive DFGout‑None in-in none-out TYR APEdihe_iioai APEdist_aaao 0LI Type2 465 - 765 0 None C488A,C584S Fibroblast growth factor receptor 1 Homo sapiens
TYR FGFR1 FGFR1_HUMAN 4V01B 2.33 Inactive DFGout‑None in-in none-out TYR APEdihe_iioai APEdist_aaao 0LI Type2 461 - 763 0 None C488A,C584S Fibroblast growth factor receptor 1 Homo sapiens
TYR FGFR1 FGFR1_HUMAN 4V04A 2.12 Inactive DFGout‑None in-in none-out TYR APEdihe_iioai APEdist_aaao 0LI Type2 463 - 765 0 None C488A,C584S Fibroblast growth factor receptor 1 Homo sapiens
TYR FGFR4 FGFR4_HUMAN 4QRCA 1.901 Inactive DFGout‑None in-in out-out TYR APEdihe_iioai APEdist_aaao 0LI Type2 454 - 750 0 None C477A,R664E Fibroblast growth factor receptor 4 Homo sapiens
TYR FGR FGR_HUMAN 7UY3A 2.99 Inactive DFGout‑None in-in out-none TYR APEdihe_nniai APEdist_aaai OJL Type2 135 - 527 0 PTR523 Q524E,P525E,G526I,D527P Tyrosine-protein kinase Fgr Homo sapiens
TYR FLT3 FLT3_HUMAN 1RJBA 2.1 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 572 - 947 0 None None Receptor-type tyrosine-protein kinase FLT3 Homo sapiens
TYR FLT3 FLT3_HUMAN 6JQRA 2.2 Inactive DFGout‑None in-in none-in TYR APEdihe_iiiai APEdist_aaai C6F Type1 571 - 951 0 None None Receptor-type tyrosine-protein kinase FLT3 Homo sapiens
TYR FLT3 FLT3_HUMAN 8XB1A 2.85 Inactive DFGout‑None in-in none-in TYR APEdihe_iiiai APEdist_aaai ZX3 Type1 573 - 950 0 None None Receptor-type tyrosine-protein kinase FLT3 Homo sapiens
TYR FLT3 FLT3_HUMAN 5X02A 2.401 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai F6M Type1 573 - 947 0 None None Receptor-type tyrosine-protein kinase FLT3 Homo sapiens
TYR FLT3 FLT3_HUMAN 6IL3A 2.5 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai A9R Type1 569 - 947 0 None None Receptor-type tyrosine-protein kinase FLT3 Homo sapiens
TYR IGF1R IGF1R_HUMAN 3O23A 2.1 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai MQY Type2 991 - 1283 0 None Y987F Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 8PYJAAA 2.702 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai IEA Type2 986 - 1270 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 8PYKAAA 2.23 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai IC2 Type2 986 - 1270 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 8PYLAAA 2.93 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai IE0 Type2 986 - 1270 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 8PYMAAA 2.652 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai IED Type2 984 - 1270 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 8PYNAAA 1.71 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai ICV Type2 986 - 1270 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 3LW0D 1.79 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai CCX, CCX Type3, Allosteric 983 - 1286 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
TYR KDR VGFR2_HUMAN 3C7QA 2.1 Inactive DFGout‑None in-in none-out TYR APEdihe_iioai APEdist_aaao XIN Type1 819 - 1171 0 PTR1054,PTR1059 None Vascular endothelial growth factor receptor 2 Homo sapiens
TYR KDR VGFR2_HUMAN 2P2IB 2.4 Inactive DFGout‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan 608 Type1 820 - 1168 0 PTR1054,PTR1059 C817A,E990V Vascular endothelial growth factor receptor 2 Homo sapiens
TYR KDR VGFR2_HUMAN 3VNTA 1.64 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai 0JA Type2 812 - 1168 0 None None Vascular endothelial growth factor receptor 2 Homo sapiens
TYR KDR VGFR2_HUMAN 3VO3A 1.52 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai 0KF Type2 812 - 1168 0 None None Vascular endothelial growth factor receptor 2 Homo sapiens
TYR KDR VGFR2_HUMAN 2QU6B 2.1 Inactive DFGout‑None in-in none-out TYR APEdihe_nniai APEdist_aaao 857 Type2 822 - 1165 0 PTR1054,PTR1059 C817A,V916T,E990V Vascular endothelial growth factor receptor 2 Homo sapiens
TYR KDR VGFR2_HUMAN 3B8QA 2.75 Inactive DFGout‑None in-in none-out TYR APEdihe_nnoai APEdist_aaao 900 Type2 818 - 1171 0 PTR1054,PTR1059 C817A,V916T,E990V Vascular endothelial growth factor receptor 2 Homo sapiens
TYR KDR VGFR2_HUMAN 3CPBA 2.7 Inactive DFGout‑None in-in none-out TYR APEdihe_nnoai APEdist_aaao C92 Type2 819 - 1171 0 PTR1054,PTR1059 C817A,V916T,E990V Vascular endothelial growth factor receptor 2 Homo sapiens
TYR KDR VGFR2_HUMAN 3CPCA 2.4 Inactive DFGout‑None in-out none-out TYR APEdihe_nnoai APEdist_aaao C52 Type2 820 - 1171 0 PTR1054,PTR1059 C817A,V916T,E990V Vascular endothelial growth factor receptor 2 Homo sapiens
TYR KDR VGFR2_HUMAN 3DTWA 2.9 Inactive DFGout‑None in-in none-out TYR APEdihe_nnoai APEdist_aaao A96 Type2 818 - 1171 0 PTR1054,PTR1059 C817A,V916T,E990V Vascular endothelial growth factor receptor 2 Homo sapiens
TYR KIT KIT_HUMAN 1T45A 1.9 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 547 - 935 0 None None Mast/stem cell growth factor receptor Kit Homo sapiens
TYR KIT KIT_HUMAN 3G0EA 1.6 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai B49 Type1 544 - 931 0 None None Mast/stem cell growth factor receptor Kit Homo sapiens
TYR KIT KIT_HUMAN 8S1BA 2.0 Inactive DFGout‑None in-in none-in TYR APEdihe_iiiai APEdist_aaai K3R Type2 565 - 931 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
TYR LCK LCK_HUMAN 2OFVA 2.0 Inactive DFGout‑None in-in none-none TYR APEdihe_nnnan APEdist_aaan 242 Type2 232 - 498 0 None None Tyrosine-protein kinase Lck Homo sapiens
TYR LCK LCK_HUMAN 2OFVB 2.0 Inactive DFGout‑None in-in out-none TYR APEdihe_nnnai APEdist_aaan 242 Type2 232 - 498 0 None None Tyrosine-protein kinase Lck Homo sapiens
TYR MERTK MERTK_HUMAN 7AVXB 2.44 Inactive DFGout‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan S4K Type1 577 - 862 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 9KRZA 2.6 Inactive DFGout‑None out-none none-none TYR APEdihe_nnnai APEdist_aaan A1L6K Type1.5_Front 577 - 864 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 9KRZB 2.6 Inactive DFGout‑None out-none none-none TYR APEdihe_nnnai APEdist_aaan A1L6K Type1.5_Front 575 - 863 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 9KRYA 2.25 Inactive DFGout‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan A1L6J Type2 580 - 863 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 9KS9A 2.8 Inactive DFGout‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan A1L6L Type2 576 - 862 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 7AAXA 1.762 Inactive DFGout‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan R6H Type2 571 - 862 0 None K591R,K693R,K702R,K856R Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 7AW1A 1.98 Inactive DFGout‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan S4T Type2 571 - 862 0 None K591R,K693R,K702R,K856R Tyrosine-protein kinase Mer Homo sapiens
TYR MET MET_HUMAN 3RHKA 1.94 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai M97 Type1 1049 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
TYR MET MET_HUMAN 3EFJA 2.6 Inactive DFGout‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan MT3 Type1.5_Front 1054 - 1351 0 None L1272L Hepatocyte growth factor receptor Homo sapiens
TYR MET MET_HUMAN 5DG5A 2.6 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 5B4 Type2 1050 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
TYR MET MET_HUMAN 5DG5B 2.6 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 5B4 Type2 1050 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
TYR MET MET_HUMAN 7V3RA 1.7 Inactive DFGout‑None in-out out-none TYR APEdihe_nniai APEdist_aaai 5IE Type2 1053 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
TYR MET MET_HUMAN 3CTJA 2.5 Inactive DFGout‑None in-in none-none TYR APEdihe_nniai APEdist_aaai 320 Type2 1051 - 1360 0 None Y1194F,Y1234F,Y1235D Hepatocyte growth factor receptor Homo sapiens
TYR MET MET_HUMAN 3C1XA 2.17 Inactive DFGout‑None in-out none-none TYR APEdihe_nniai APEdist_aaai CKK Type2 1050 - 1360 0 None Y1194F,Y1234F,Y1235D,L1272L Hepatocyte growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 6D20A 1.94 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai FQD, FQG Allosteric, Type3 482 - 796 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 4F0IA 2.302 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 501 - 790 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 4F0IB 2.302 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 501 - 794 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 4GT5A 2.398 Inactive DFGout‑None in-none out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 498 - 793 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 6D22A 2.46 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 502 - 794 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 6DKBA 2.68 Inactive DFGout‑None out-in none-none TYR APEdihe_niiai APEdist_aaai FKY Type1 501 - 796 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 5KMOA 2.67 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai 6UM Type1 500 - 796 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 4PMSA 2.8 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 31X Type1.5_Back 501 - 787 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 8J5WA 2.28 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai A4U Type2 485 - 795 0 None F589L High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 8J61A 3.051 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai A0X Type2 499 - 795 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 8J63A 3.001 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai A6X Type2 500 - 796 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 5WR7A 2.76 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai RCH Type2 489 - 792 0 SEP677 None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 6PL1A 2.03 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai OOJ Type2 500 - 795 0 SEP677 None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 6PL3A 3.0 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai OOD Type2 500 - 795 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 6PMAA 2.53 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai OQS Type2 500 - 795 0 SEP677 None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 6PMBA 2.81 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai OQM Type2 500 - 795 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 6PMCA 2.19 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai OQJ Type2 500 - 795 0 SEP677 None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 6NSPA 2.31 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai L0P Type3 500 - 795 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 6NPTA 2.19 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai KWY Type3 491 - 795 0 SEP677 None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 6NSSA 1.97 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai L0M Type3 485 - 795 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 6D1YA 1.93 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai FQJ Type3 481 - 796 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 5KMIA 1.87 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 6UE Type3 486 - 796 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 5KMJA 2.04 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai 6UF Type3 486 - 795 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 5KMKA 2.24 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 6UG Type3 484 - 796 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 5KMMA 2.12 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 6UJ Type3 484 - 796 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 5KMLA 2.01 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 6UH Type3 474 - 796 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 5KMNA 2.14 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 6UK Type3 474 - 796 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK2 NTRK2_HUMAN 4ASZA 1.7 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 527 - 822 0 None None BDNF/NT-3 growth factors receptor Homo sapiens
TYR NTRK2 NTRK2_HUMAN 4AT5A 1.71 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai MUJ Type2 527 - 822 0 None None BDNF/NT-3 growth factors receptor Homo sapiens
TYR NTRK3 NTRK3_HUMAN 4YMJA 2.0 Inactive DFGout‑None out-out none-in TYR APEdihe_iiiai APEdist_aaai 4EJ Type1 530 - 831 0 SEP706 None NT-3 growth factor receptor Homo sapiens
TYR NTRK3 NTRK3_HUMAN 4YMJB 2.0 Inactive DFGout‑None out-none out-in TYR APEdihe_iiiai APEdist_aaai 4EJ Type1 530 - 834 0 SEP706 None NT-3 growth factor receptor Homo sapiens
TYR PDGFRA PGFRA_HUMAN 8PQKA 2.0 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 554 - 973 0 None T674I Platelet-derived growth factor receptor alpha Homo sapiens
TYR PDGFRA PGFRA_HUMAN 6A32A 1.87 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 554 - 973 0 None T674I Platelet-derived growth factor receptor alpha Homo sapiens
TYR PDGFRA PGFRA_HUMAN 8PQJA 1.82 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 553 - 973 0 None None Platelet-derived growth factor receptor alpha Homo sapiens
TYR PDGFRA PGFRA_HUMAN 5K5XA 2.168 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 554 - 973 0 None None Platelet-derived growth factor receptor alpha Homo sapiens
TYR PDGFRA PGFRA_HUMAN 6JOKA 3.8 Inactive DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai B49 Type1 556 - 973 0 None None Platelet-derived growth factor receptor alpha Homo sapiens
TYR PTK2 FAK1_HUMAN 4EBVA 1.67 Inactive DFGout‑None in-in none-out TYR APEdihe_niiai APEdist_aaao 0O7 Type1 411 - 686 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2 FAK1_HUMAN 4K9YA 2.0 Inactive DFGout‑None in-in out-out TYR APEdihe_oiiai APEdist_aaao K9Y Type2 415 - 685 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2 FAK1_HUMAN 4I4FA 1.75 Inactive DFGout‑None out-out none-out TYR APEdihe_niiai APEdist_aaao 1BR Type3 415 - 686 0 None None Focal adhesion kinase 1 Homo sapiens
TYR PTK2B FAK2_HUMAN 3FZPA 2.1 Inactive DFGout‑None in-out none-in TYR APEdihe_iiiai APEdist_aaai AGS ATPlike 419 - 692 0 None None Protein-tyrosine kinase 2-beta Homo sapiens
TYR PTK2B FAK2_HUMAN 3ET7A 2.7 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai 349 Type1 419 - 691 0 None None Protein-tyrosine kinase 2-beta Homo sapiens
TYR PTK2B FAK2_HUMAN 3FZRA 2.7 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai 3JZ Type1 419 - 691 0 None None Protein-tyrosine kinase 2-beta Homo sapiens
TYR PTK2B FAK2_HUMAN 5TO8A 1.985 Inactive DFGout‑None in-none out-none TYR APEdihe_nnnan APEdist_aaan 7FM Type1 420 - 691 0 None None Protein-tyrosine kinase 2-beta Homo sapiens
TYR PTK2B FAK2_HUMAN 3FZTA 1.95 Inactive DFGout‑None in-in out-none TYR APEdihe_nniai APEdist_aaai 4JZ Type2 420 - 690 0 None None Protein-tyrosine kinase 2-beta Homo sapiens
TYR PTK2B FAK2_HUMAN 4H1JA 2.0 Inactive DFGout‑None in-in out-out TYR APEdihe_oiiai APEdist_aaai 0YH Type2 419 - 690 0 None None Protein-tyrosine kinase 2-beta Homo sapiens
TYR ROR2 ROR2_HUMAN 3ZZWB 2.9 Pseudo DFGout‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 466 - 750 0 None None Tyrosine-protein kinase transmembrane receptor ROR2 Homo sapiens
TYR SYK KSYK_HUMAN 3TUDA 2.33 Inactive DFGout‑None in-in none-in TYR APEdihe_iiiai APEdist_aaai FPX Type2 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
TYR TEK TIE2_HUMAN 2WQBA 2.95 Inactive DFGout‑None none-none out-out TYR APEdihe_iiiai APEdist_aaao QQ1 Type1 816 - 1120 0 None D964N Angiopoietin-1 receptor Homo sapiens
TYR TEK TIE2_HUMAN 2P4IB 2.5 Inactive DFGout‑None in-in none-out TYR APEdihe_iiiai APEdist_aaao MR9 Type2 836 - 1117 0 None None Angiopoietin-1 receptor Homo sapiens
TYR TEK TIE2_HUMAN 4X3JA 2.5 Inactive DFGout‑None in-out none-out TYR APEdihe_nniai APEdist_aaao 3WR Type2 838 - 1117 0 None D964N Angiopoietin-1 receptor Homo sapiens
TYR TNK2 ACK1_HUMAN 5ZXBA 2.198 Inactive DFGout‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan 9KO Type2 117 - 389 0 None None Activated CDC42 kinase 1 Homo sapiens
TYR TNK2 ACK1_HUMAN 5ZXBB 2.198 Inactive DFGout‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan 9KO Type2 117 - 389 0 None None Activated CDC42 kinase 1 Homo sapiens
CMGC MPK3 A0A3S7WR45_LEIDO 4O2ZA 2.71 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaoii APEdist_oioo 046 Type2 5 - 363 0 None None Mitogen-activated protein kinase Leishmania donovani
AGC RPS6KA3-1 KS6A3_MOUSE 3UBDA 1.53 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_iioo SL0 Type1 49 - 346 0 None None Ribosomal protein S6 kinase alpha-3 Mus musculus
AGC RPS6KA3-1 KS6A3_MOUSE 4EL9A 1.55 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_oioo AFE Type1 49 - 346 0 None None Ribosomal protein S6 kinase alpha-3 Mus musculus
AGC RPS6KA3-1 KS6A3_MOUSE 4GUEA 1.8 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_oioo QCT Type1 48 - 346 0 None None Ribosomal protein S6 kinase alpha-3 Mus musculus
CMGC MAPK14 MK14_MOUSE 7BDOA 2.7 Inactive DFGout‑None in-out none-out nonTYR APEdihe_aaoii APEdist_nnno TBK Type2 5 - 353 0 None None Mitogen-activated protein kinase 14 Mus musculus
TKL RIPK3 RIPK3_MOUSE 6OKOA 2.1 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno 1FN Type2 14 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
TKL RIPK3 RIPK3_MOUSE 6OKOB 2.1 Inactive DFGout‑None in-out none-none nonTYR APEdihe_aannn APEdist_nnnn 1FN Type2 13 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
TKL RIPK3 RIPK3_MOUSE 9IX2A 2.39 Inactive DFGout‑None in-none none-out nonTYR APEdihe_aanoi APEdist_nnnn 1SU Type2 15 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
TKL RIPK3 RIPK3_MOUSE 9IX3A 2.07 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn A1EAA Type2 15 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
TKL RIPK3 RIPK3_MOUSE 9IX3B 2.07 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn A1EAA Type2 15 - 310 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
TYR ABL1 ABL1_MOUSE 1M52A 2.6 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai P17 Type1.5_Back 232 - 502 0 None None Tyrosine-protein kinase ABL1 Mus musculus
TYR ABL1 ABL1_MOUSE 1M52B 2.6 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai P17 Type1.5_Back 232 - 503 0 None None Tyrosine-protein kinase ABL1 Mus musculus
TYR ABL1 ABL1_MOUSE 1OPKA 1.8 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai P16 Type1.5_Back 64 - 512 0 None D363N Tyrosine-protein kinase ABL1 Mus musculus
OTHER PKNE PKNE_MYCTU 2H34A 2.8 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 14 - 276 0 None None Serine/threonine-protein kinase PknE Mycobacterium tuberculosis
OTHER PKNE PKNE_MYCTU 2H34B 2.8 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 14 - 276 0 None None Serine/threonine-protein kinase PknE Mycobacterium tuberculosis
CMGC MAPK1 MK01_RAT 4I5HA 1.9 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaioi APEdist_iioo G17 Type2 9 - 356 0 None Q103A,C164L Mitogen-activated protein kinase 1 Rattus norvegicus
CMGC P38A A9UJZ9_SALSA 3OHTA 2.7 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn 1N1, 1N1 Type1.5_Back, Allosteric 5 - 352 0 None None mitogen-activated protein kinase Salmo salar
CMGC P38A A9UJZ9_SALSA 3OHTB 2.7 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn 1N1, 1N1 Type1.5_Back, Allosteric 5 - 352 0 None None mitogen-activated protein kinase Salmo salar
OTHER TCUR0376 D1A2F7_THECD 8CAVA 2.87 Inactive DFGout‑None out-na in-out nonTYR APEdihe_aaiii APEdist_oiii ANP Allosteric 6 - 865 0 None None Serine/threonine protein kinase Thermomonospora curvata
OTHER TCUR0376 D1A2F7_THECD 8CAVB 2.87 Inactive DFGout‑None out-na in-out nonTYR APEdihe_aaiii APEdist_oiii ANP Allosteric 6 - 863 0 None None Serine/threonine protein kinase Thermomonospora curvata
CMGC PRP4K S7UT92_TOXGG 7Q4AA 2.31 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaoii APEdist_oooo A9I Type2 547 - 894 0 PTR729 None non-specific serine/threonine protein kinase Toxoplasma gondii
CMGC PRP4K S7UT92_TOXGG 7Q4AB 2.31 Inactive DFGout‑None in-out out-out nonTYR APEdihe_aaoii APEdist_oioo A9I Type2 546 - 891 0 PTR729 None non-specific serine/threonine protein kinase Toxoplasma gondii
OTHER IKBKBL Q6INT1_XENLA 3QA8A 3.6 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaiii APEdist_iioo No_ligand No_ligand 1 - 650 0 None S161E,S165E IkappaB kinase Xenopus laevis
OTHER IKBKBL Q6INT1_XENLA 3QA8B 3.6 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaiii APEdist_iioo No_ligand No_ligand 1 - 650 0 None S161E,S165E IkappaB kinase Xenopus laevis
OTHER IKBKBL Q6INT1_XENLA 3QA8C 3.6 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaiii APEdist_iioo No_ligand No_ligand 1 - 650 0 None S161E,S165E IkappaB kinase Xenopus laevis
OTHER IKBKBL Q6INT1_XENLA 3QA8D 3.6 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaiii APEdist_iioo No_ligand No_ligand 1 - 650 0 None S161E,S165E IkappaB kinase Xenopus laevis
OTHER IKBKBL Q6INT1_XENLA 3QA8E 3.6 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaiii APEdist_iioo No_ligand No_ligand 1 - 650 0 None S161E,S165E IkappaB kinase Xenopus laevis
OTHER IKBKBL Q6INT1_XENLA 3QA8F 3.6 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaiii APEdist_iioo No_ligand No_ligand 1 - 650 0 None S161E,S165E IkappaB kinase Xenopus laevis
OTHER IKBKBL Q6INT1_XENLA 3QA8G 3.6 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaiii APEdist_iioo No_ligand No_ligand 1 - 621 0 None S161E,S165E IkappaB kinase Xenopus laevis
OTHER IKBKBL Q6INT1_XENLA 3QA8H 3.6 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaiii APEdist_iioo No_ligand No_ligand 1 - 621 0 None S161E,S165E IkappaB kinase Xenopus laevis

All / DFGoutNone / All

Total number of chains: 45
Active chains: 0
Total number of genes: 14
Spatial label Dihedral label Number of Chains Percent Representative
DFGout None 45 100.0% 4I93A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
OTHER BSK8 BSK8_ARATH 4I94A 1.8 Pseudo DFGout‑None out-out out-out nonTYR APEdihe_aaiai APEdist_iioo ANP ATPlike 40 - 328 0 None None Serine/threonine-protein kinase BSK8 Arabidopsis thaliana
OTHER BSK8 BSK8_ARATH 4I94B 1.8 Pseudo DFGout‑None out-out out-out nonTYR APEdihe_aaiai APEdist_iioo ANP ATPlike 40 - 328 0 None None Serine/threonine-protein kinase BSK8 Arabidopsis thaliana
OTHER BSK8 BSK8_ARATH 4I92A 1.6 Pseudo DFGout‑None out-out out-out nonTYR APEdihe_aaiai APEdist_iooo No_ligand No_ligand 40 - 328 0 None None Serine/threonine-protein kinase BSK8 Arabidopsis thaliana
OTHER BSK8 BSK8_ARATH 4I93A 1.5 Pseudo DFGout‑None out-out out-out nonTYR APEdihe_aaiai APEdist_iioo No_ligand No_ligand 40 - 328 0 None None Serine/threonine-protein kinase BSK8 Arabidopsis thaliana
OTHER BSK8 BSK8_ARATH 4I93B 1.5 Pseudo DFGout‑None out-out out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 40 - 328 0 None None Serine/threonine-protein kinase BSK8 Arabidopsis thaliana
TKL CTR1 CTR1_ARATH 3P86A 2.496 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno STU Type1 544 - 810 0 None D676N Serine/threonine-protein kinase CTR1 Arabidopsis thaliana
TYR SRC SRC_CHICK 3D7TB 2.899 Inactive DFGout‑None in-in out-none TYR APEdihe_niiai APEdist_aaai STU Type1 258 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 5K9IB 2.5 Inactive DFGout‑None out-out in-none TYR APEdihe_nniai APEdist_aaai O44 Type1 259 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 7D5OB 2.69 Inactive DFGout‑None out-out none-out TYR APEdihe_nniai APEdist_aaao TZ0 Type1 258 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3EL7A 2.8 Inactive DFGout‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan PD3 Type2 257 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3EL8A 2.3 Inactive DFGout‑None in-in in-out TYR APEdihe_nnoai APEdist_aaao PD5 Type2 258 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3G6GB 2.31 Inactive DFGout‑None in-in none-out TYR APEdihe_iioai APEdist_aaao G6G Type2 256 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 4AGWA 2.6 Inactive DFGout‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan NG7 Type2 257 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 4AGWB 2.6 Inactive DFGout‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan NG7 Type2 258 - 533 0 None None Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3TZ9B 3.1 Inactive DFGout‑None in-in none-out TYR APEdihe_nnoai APEdist_aaao AQU Type2 257 - 533 0 None S345C Proto-oncogene tyrosine-protein kinase Src Gallus gallus
CMGC MPK3 A0A3S7WR45_LEIDO 4O2ZA 2.71 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaoii APEdist_oioo 046 Type2 5 - 363 0 None None Mitogen-activated protein kinase Leishmania donovani
AGC RPS6KA3-1 KS6A3_MOUSE 3UBDA 1.53 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_iioo SL0 Type1 49 - 346 0 None None Ribosomal protein S6 kinase alpha-3 Mus musculus
AGC RPS6KA3-1 KS6A3_MOUSE 4EL9A 1.55 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_oioo AFE Type1 49 - 346 0 None None Ribosomal protein S6 kinase alpha-3 Mus musculus
AGC RPS6KA3-1 KS6A3_MOUSE 4GUEA 1.8 Inactive DFGout‑None none-none out-out nonTYR APEdihe_aaiii APEdist_oioo QCT Type1 48 - 346 0 None None Ribosomal protein S6 kinase alpha-3 Mus musculus
CMGC MAPK14 MK14_MOUSE 7BDOA 2.7 Inactive DFGout‑None in-out none-out nonTYR APEdihe_aaoii APEdist_nnno TBK Type2 5 - 353 0 None None Mitogen-activated protein kinase 14 Mus musculus
TKL RIPK3 RIPK3_MOUSE 6OKOA 2.1 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno 1FN Type2 14 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
TKL RIPK3 RIPK3_MOUSE 6OKOB 2.1 Inactive DFGout‑None in-out none-none nonTYR APEdihe_aannn APEdist_nnnn 1FN Type2 13 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
TKL RIPK3 RIPK3_MOUSE 9IX2A 2.39 Inactive DFGout‑None in-none none-out nonTYR APEdihe_aanoi APEdist_nnnn 1SU Type2 15 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
TKL RIPK3 RIPK3_MOUSE 9IX3A 2.07 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn A1EAA Type2 15 - 311 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
TKL RIPK3 RIPK3_MOUSE 9IX3B 2.07 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn A1EAA Type2 15 - 310 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
TYR ABL1 ABL1_MOUSE 1M52A 2.6 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai P17 Type1.5_Back 232 - 502 0 None None Tyrosine-protein kinase ABL1 Mus musculus
TYR ABL1 ABL1_MOUSE 1M52B 2.6 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai P17 Type1.5_Back 232 - 503 0 None None Tyrosine-protein kinase ABL1 Mus musculus
TYR ABL1 ABL1_MOUSE 1OPKA 1.8 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai P16 Type1.5_Back 64 - 512 0 None D363N Tyrosine-protein kinase ABL1 Mus musculus
OTHER PKNE PKNE_MYCTU 2H34A 2.8 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 14 - 276 0 None None Serine/threonine-protein kinase PknE Mycobacterium tuberculosis
OTHER PKNE PKNE_MYCTU 2H34B 2.8 Inactive DFGout‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 14 - 276 0 None None Serine/threonine-protein kinase PknE Mycobacterium tuberculosis
CMGC MAPK1 MK01_RAT 4I5HA 1.9 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaioi APEdist_iioo G17 Type2 9 - 356 0 None Q103A,C164L Mitogen-activated protein kinase 1 Rattus norvegicus
CMGC P38A A9UJZ9_SALSA 3OHTA 2.7 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn 1N1, 1N1 Type1.5_Back, Allosteric 5 - 352 0 None None mitogen-activated protein kinase Salmo salar
CMGC P38A A9UJZ9_SALSA 3OHTB 2.7 Inactive DFGout‑None in-in none-none nonTYR APEdihe_aannn APEdist_nnnn 1N1, 1N1 Type1.5_Back, Allosteric 5 - 352 0 None None mitogen-activated protein kinase Salmo salar
OTHER TCUR0376 D1A2F7_THECD 8CAVA 2.87 Inactive DFGout‑None out-na in-out nonTYR APEdihe_aaiii APEdist_oiii ANP Allosteric 6 - 865 0 None None Serine/threonine protein kinase Thermomonospora curvata
OTHER TCUR0376 D1A2F7_THECD 8CAVB 2.87 Inactive DFGout‑None out-na in-out nonTYR APEdihe_aaiii APEdist_oiii ANP Allosteric 6 - 863 0 None None Serine/threonine protein kinase Thermomonospora curvata
CMGC PRP4K S7UT92_TOXGG 7Q4AA 2.31 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaoii APEdist_oooo A9I Type2 547 - 894 0 PTR729 None non-specific serine/threonine protein kinase Toxoplasma gondii
CMGC PRP4K S7UT92_TOXGG 7Q4AB 2.31 Inactive DFGout‑None in-out out-out nonTYR APEdihe_aaoii APEdist_oioo A9I Type2 546 - 891 0 PTR729 None non-specific serine/threonine protein kinase Toxoplasma gondii
OTHER IKBKBL Q6INT1_XENLA 3QA8A 3.6 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaiii APEdist_iioo No_ligand No_ligand 1 - 650 0 None S161E,S165E IkappaB kinase Xenopus laevis
OTHER IKBKBL Q6INT1_XENLA 3QA8B 3.6 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaiii APEdist_iioo No_ligand No_ligand 1 - 650 0 None S161E,S165E IkappaB kinase Xenopus laevis
OTHER IKBKBL Q6INT1_XENLA 3QA8C 3.6 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaiii APEdist_iioo No_ligand No_ligand 1 - 650 0 None S161E,S165E IkappaB kinase Xenopus laevis
OTHER IKBKBL Q6INT1_XENLA 3QA8D 3.6 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaiii APEdist_iioo No_ligand No_ligand 1 - 650 0 None S161E,S165E IkappaB kinase Xenopus laevis
OTHER IKBKBL Q6INT1_XENLA 3QA8E 3.6 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaiii APEdist_iioo No_ligand No_ligand 1 - 650 0 None S161E,S165E IkappaB kinase Xenopus laevis
OTHER IKBKBL Q6INT1_XENLA 3QA8F 3.6 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaiii APEdist_iioo No_ligand No_ligand 1 - 650 0 None S161E,S165E IkappaB kinase Xenopus laevis
OTHER IKBKBL Q6INT1_XENLA 3QA8G 3.6 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaiii APEdist_iioo No_ligand No_ligand 1 - 621 0 None S161E,S165E IkappaB kinase Xenopus laevis
OTHER IKBKBL Q6INT1_XENLA 3QA8H 3.6 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aaiii APEdist_iioo No_ligand No_ligand 1 - 621 0 None S161E,S165E IkappaB kinase Xenopus laevis