All / DFGinter / All

Total number of chains: 228
Active chains: 0
Total number of genes: 44
Spatial label Dihedral label Number of Chains Percent Representative
DFGinter None 204 89.5% 4U3YA
DFGinter BABtrans 24 10.5% 7YC9A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AGC ROCK1 ROCK1_HUMAN 3TWJB 2.9 Inactive DFGinter‑None in-in out-out nonTYR APEdihe_aaioi APEdist_iioi No_ligand No_ligand 8 - 402 0 None None Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 3TWJD 2.9 Inactive DFGinter‑None in-in out-out nonTYR APEdihe_aaioi APEdist_iioi No_ligand No_ligand 8 - 402 0 None None Rho-associated protein kinase 1
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOC 2.75 Inactive DFGinter‑None none-none out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 46 - 347 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOG 2.75 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanni APEdist_oonn ANP ATPlike 46 - 348 0 None None Ribosomal protein S6 kinase alpha-3
AGC RPS6KA5-1 KS6A5_HUMAN 1VZOA 1.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iooo No_ligand No_ligand 24 - 345 0 None S212D Ribosomal protein S6 kinase alpha-5
AGC RPS6KA6-1 KS6A6_HUMAN 6G76B 3.0 Inactive DFGinter‑None none-none out-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 51 - 349 0 SEP232 None Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G78A 2.5 Inactive DFGinter‑None none-none out-out nonTYR APEdihe_aaoii APEdist_nnno ANP ATPlike 51 - 349 0 None S232E Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G78B 2.5 Inactive DFGinter‑None none-none out-out nonTYR APEdihe_aaiii APEdist_nnno ANP ATPlike 51 - 349 0 None S232E Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G76A 3.0 Inactive DFGinter‑None none-none out-out nonTYR APEdihe_aaiii APEdist_iooi ANP, ANP ATPlike, Allosteric 51 - 349 0 SEP232 None Ribosomal protein S6 kinase alpha-6
AGC SGK1 SGK1_HUMAN 2R5TA 1.9 Inactive DFGinter‑None none-none out-out nonTYR APEdihe_aaiio APEdist_oooo ANP ATPlike 82 - 378 0 None S74A,S78A,S397A,S401A Serine/threonine-protein kinase Sgk1
AGC SGK1 SGK1_HUMAN 3HDMA 2.6 Inactive DFGinter‑None none-none out-out nonTYR APEdihe_aaiio APEdist_oooo MMG Type1 81 - 378 0 None S74A,S78A,S397A,S401A Serine/threonine-protein kinase Sgk1
AGC SGK1 SGK1_HUMAN 3HDNA 3.1 Inactive DFGinter‑None none-none out-out nonTYR APEdihe_aaiio APEdist_oooo GMG Type1 82 - 374 0 None S74A,S78A,S397A,S401A Serine/threonine-protein kinase Sgk1
CAMK AURKA AURKA_HUMAN 4C3RA 2.79 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno ACP ATPlike 127 - 388 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 6C83B 2.55 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnno ACP ATPlike 127 - 388 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 5L8JA 1.68 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn ADP ATPlike 126 - 391 0 TPO288 C290A,C393A Aurora kinase A
CAMK AURKA AURKA_HUMAN 5L8KA 1.79 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ADP ATPlike 126 - 392 0 TPO288 C290A,C393A Aurora kinase A
CAMK AURKA AURKA_HUMAN 5L8LA 1.67 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_iooo ADP ATPlike 126 - 389 0 TPO288 C290A,C393A Aurora kinase A
CAMK AURKA AURKA_HUMAN 8PR7A 2.76 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnno ADP ATPlike 124 - 389 0 None D274N,C290A,N332A,Q335A,T347A,D350A,C393A Aurora kinase A
CAMK AURKA AURKA_HUMAN 6XKAA 2.65 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_nnno No_ligand No_ligand 127 - 388 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 2WTVA 2.4 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_iioo ZZL Type1 125 - 389 0 TPO287,TPO288 L215R,T217E,R220K Aurora kinase A
CAMK AURKA AURKA_HUMAN 2WTVB 2.4 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ZZL Type1 126 - 389 0 TPO287,TPO288 L215R,T217E,R220K Aurora kinase A
CAMK AURKA AURKA_HUMAN 2WTVC 2.4 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ZZL Type1 126 - 389 0 TPO287,TPO288 L215R,T217E,R220K Aurora kinase A
CAMK AURKA AURKA_HUMAN 2WTVD 2.4 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_iioo ZZL Type1 125 - 389 0 TPO287,TPO288 L215R,T217E,R220K Aurora kinase A
CAMK AURKA AURKA_HUMAN 5EW9A 2.181 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioo 5VC Type1 127 - 390 0 TPO287,TPO288 None Aurora kinase A
CAMK AURKA AURKA_HUMAN 6C2RA 1.96 Inactive DFGinter‑None out-none out-out nonTYR APEdihe_aanoi APEdist_nnnn EG7 Type1 128 - 389 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 6C2TA 1.73 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo EGJ Type1 128 - 388 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 3W16A 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioo APEdist_nnno P9J Type1 126 - 388 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 2J50A 3.0 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_oooo 627 Type1 128 - 389 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 2J50B 3.0 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_oooo 627 Type1 128 - 389 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 4ZTRA 2.85 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 4RJ Type1 127 - 388 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 6Z4YA 2.25 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo Q7Q Type1 124 - 389 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 6CPGA 2.8 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaoni APEdist_nnoo 35R Type1 127 - 387 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 6CPGD 2.8 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nooo 35R Type1 127 - 388 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 8SSOA 1.97 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_nooo 627 Type1 127 - 389 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 8SSOD 1.97 Inactive DFGinter‑None out-out out-none nonTYR APEdihe_aanii APEdist_nnnn 627 Type1 127 - 389 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 1MUOA 2.9 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaoii APEdist_nooo ADN Type1 128 - 388 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 2J4ZA 2.0 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oioo 626 Type1 126 - 389 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UNZA 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0BZ Type1 127 - 389 0 None T287D Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UNZB 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0BZ Type1 127 - 389 0 None T287D Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UO6A 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0BY Type1 126 - 389 0 None T287D Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UO6B 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0BY Type1 126 - 389 0 None T287D Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UOHA 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C4 Type1 126 - 389 0 None T287D Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UOHB 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C4 Type1 126 - 389 0 None T287D Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UOJA 2.9 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C5 Type1 127 - 389 0 None T287D Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UOJB 2.9 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C5 Type1 127 - 389 0 None T287D Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UOKA 2.951 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C6 Type1 125 - 389 0 None T287D Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UOKB 2.951 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C6 Type1 125 - 389 0 None T287D Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UOLA 2.4 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C7 Type1 127 - 389 0 None T287D Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UOLB 2.4 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C7 Type1 127 - 389 0 None T287D Aurora kinase A
CAMK AURKA AURKA_HUMAN 3FDNA 1.9 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo MMH Type1 126 - 394 0 None T288D Aurora kinase A
CAMK AURKA AURKA_HUMAN 3K5UA 2.35 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo PFQ Type1 126 - 394 0 None T288D Aurora kinase A
CAMK AURKA AURKA_HUMAN 4JBQA 2.3 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo VX6 Type1 126 - 391 0 None T288D Aurora kinase A
CAMK AURKA AURKA_HUMAN 3LAUA 2.1 Inactive DFGinter‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn OFI Type1 125 - 391 0 None T288D Aurora kinase A
CAMK AURKA AURKA_HUMAN 4UZHA 2.0 Inactive DFGinter‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn JVE Type1 125 - 392 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 3H0YA 2.5 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 48B Type1 126 - 388 0 None K124A,T287A,T288A Aurora kinase A
CAMK AURKA AURKA_HUMAN 3H10A 2.2 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iooo 97B Type1 124 - 391 0 None K124A,T287A,T288A Aurora kinase A
CAMK AURKA AURKA_HUMAN 3H10B 2.2 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iooo 97B Type1 125 - 391 0 None K124A,T287A,T288A Aurora kinase A
CAMK AURKA AURKA_HUMAN 3H10D 2.2 Inactive DFGinter‑None out-out out-none nonTYR APEdihe_aanii APEdist_nnnn 97B Type1 126 - 388 0 None K124A,T287A,T288A Aurora kinase A
CAMK AURKA AURKA_HUMAN 3P9JA 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno P9J Type1 126 - 388 0 None T287A,T288A Aurora kinase A
CAMK AURKA AURKA_HUMAN 3W10A 2.7 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_iooo RO9 Type1 126 - 388 0 None T287A,T288A Aurora kinase A
CAMK AURKA AURKA_HUMAN 3R22A 2.9 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno D37 Type1 126 - 389 0 None T287D,T288D Aurora kinase A
CAMK AURKA AURKA_HUMAN 9KDSA 2.5 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnno A1EFT Type1 126 - 391 0 None C290A Aurora kinase A
CAMK AURKA AURKA_HUMAN 2BMCA 2.6 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn MPY Type1 127 - 394 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 2BMCB 2.6 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn MPY Type1 125 - 394 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 2BMCC 2.6 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn MPY Type1 125 - 393 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 2BMCD 2.6 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn MPY Type1 127 - 394 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 2BMCE 2.6 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn MPY Type1 127 - 394 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 2BMCF 2.6 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn MPY Type1 126 - 394 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 7FICA 2.32 Inactive DFGinter‑None out-none none-out nonTYR APEdihe_aaooi APEdist_nnoo 5YZ Type1 127 - 391 0 None C290A Aurora kinase A
CAMK AURKA AURKA_HUMAN 9BZGA 1.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_iioo OG0 Type1 127 - 388 0 TPO288 C290A,C393S Aurora kinase A
CAMK AURKA AURKA_HUMAN 9BZLB 1.81 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_iioo OGR Type1 127 - 388 0 TPO288 C290A,C393S Aurora kinase A
CAMK AURKA AURKA_HUMAN 9KS6A 2.75 Inactive DFGinter‑None out-na none-none nonTYR APEdihe_aanii APEdist_nnnn A1EG1 Type1 127 - 391 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 4ZTQA 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno 4RM Type1.5_Back 127 - 388 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 4ZTSA 2.9 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 4RK Type1.5_Back 127 - 388 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 3EFWA 2.29 Inactive DFGinter‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn AK8 Type1.5_Front 126 - 388 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 3EFWB 2.29 Inactive DFGinter‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn AK8 Type1.5_Front 126 - 389 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 3O50A 2.0 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn LJE Type1.5_Front 126 - 388 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 3O50B 2.0 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno LJE Type1.5_Front 126 - 389 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 6HJJA 2.13 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno G7T Type1.5_Front 127 - 393 0 None L210C,C290A,C393A Aurora kinase A
CAMK AURKB AURKB_HUMAN 4AF3A 2.75 Inactive DFGinter‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn VX6 Type1 70 - 338 0 None None Aurora kinase B
CAMK CAMK1 KCC1A_HUMAN 4FG9A 2.4 Inactive DFGinter‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn ATP ATPlike 10 - 314 0 None None Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1 KCC1A_HUMAN 4FG9B 2.4 Inactive DFGinter‑None out-none none-out nonTYR APEdihe_aaini APEdist_nnno ATP ATPlike 14 - 314 0 None None Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1 KCC1A_HUMAN 4FGBA 2.6 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iooo No_ligand No_ligand 10 - 299 0 None None Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1D KCC1D_HUMAN 6T6FA 1.97 Inactive DFGinter‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn MMW Type1 12 - 329 0 None None Calcium/calmodulin-dependent protein kinase type 1D
CAMK CAMK1D KCC1D_HUMAN 6T6FB 1.97 Inactive DFGinter‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn MMW Type1 12 - 329 0 None None Calcium/calmodulin-dependent protein kinase type 1D
CAMK CAMK1D KCC1D_HUMAN 6T29AAA 1.484 Inactive DFGinter‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn M8Z Type1 12 - 302 0 None None Calcium/calmodulin-dependent protein kinase type 1D
CAMK CAMK2A KCC2A_HUMAN 6W4OO 4.8 Inactive DFGinter‑None in-na in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 7 - 301 0 None K42M Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 6W4PH 6.6 Inactive DFGinter‑None in-na in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 7 - 301 0 None K42M Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 3SOAA 3.55 Inactive DFGinter‑None in-na in-in nonTYR APEdihe_aaiii APEdist_iiii DB8 Type1 7 - 474 0 None K42M,D135N,T306V Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK MELK MELK_HUMAN 4IXPA 2.749 Inactive DFGinter‑BABtrans out-none out-out nonTYR APEdihe_aaoii APEdist_oooo No_ligand No_ligand 2 - 335 0 None K40R,D150A Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4UMTA 1.98 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnoo 47W Type1 3 - 333 0 None N213T,V214A,M215A,Y218V,K219A Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4UMUA 2.02 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnoo 0V0 Type1 3 - 333 0 None None Maternal embryonic leucine zipper kinase
CAMK PRKAA1 AAPK1_HUMAN 4REDA 2.95 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoo APEdist_nnnn No_ligand No_ligand 22 - 360 0 None K52A 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 4REDB 2.95 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 22 - 360 0 None K52A 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK TRIB1 TRIB1_HUMAN 5CEKA 2.8 Pseudo DFGinter‑None out-na none-out nonTYR APEdihe_aanao APEdist_nnnn No_ligand No_ligand 88 - 342 0 None None Tribbles homolog 1
CAMK TRIB1 TRIB1_HUMAN 5CEMA 2.1 Pseudo DFGinter‑None out-na none-out nonTYR APEdihe_aaiao APEdist_oooo No_ligand No_ligand 88 - 364 0 None None Tribbles homolog 1
CMGC MAPK14 MK14_HUMAN 4EH9A 2.1 Inactive DFGinter‑None in-out none-out nonTYR APEdihe_aaoii APEdist_nnoo IRG, 0OQ Allosteric, Type3 5 - 354 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3GCPA 2.25 Inactive DFGinter‑None in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn SB2 Type1 4 - 352 0 None C119S,C162S,A172C,F327L Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 5WJJA 1.6 Inactive DFGinter‑None in-in out-out nonTYR APEdihe_aaoii APEdist_nnno AQY Type1 5 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 6ANLA 2.0 Inactive DFGinter‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno T75 Type1 4 - 352 0 None C119S,C162S Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 5ML5A 1.9 Inactive DFGinter‑None in-in none-none nonTYR APEdihe_aanii APEdist_nnnn 1VI Type1 5 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3HUCA 1.8 Inactive DFGinter‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno G97 Type1 4 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3ZS5A 1.6 Inactive DFGinter‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno SB2 Type1 2 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3ZSGA 1.89 Inactive DFGinter‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno T75 Type1 4 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 6HWTA 1.7 Inactive DFGinter‑None in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn GXH Type1 5 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 6HWUA 2.3 Inactive DFGinter‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnoo GE5 Type1 5 - 353 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 6HWVA 1.7 Inactive DFGinter‑None in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn GEW Type1 5 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4EHVA 1.6 Inactive DFGinter‑None in-none none-out nonTYR APEdihe_aaoii APEdist_nnoo 0SJ, 0SJ, IRG, 0SJ Type3, Allosteric, Allosteric, Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK6 MK06_HUMAN 6YKYA 2.52 Inactive DFGinter‑None in-out out-out nonTYR APEdihe_aaioi APEdist_oooo OWQ Type1 18 - 319 0 None L290V Mitogen-activated protein kinase 6
CMGC MAPK6 MK06_HUMAN 6YKYD 2.52 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo OWQ Type1 14 - 321 0 None L290V Mitogen-activated protein kinase 6
CMGC MAPK6 MK06_HUMAN 6YLCD 2.43 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo OXW Type1 13 - 321 0 None L290V Mitogen-activated protein kinase 6
NEK NEK1 NEK1_HUMAN 4APCA 2.1 Inactive DFGinter‑BABtrans out-none out-out nonTYR APEdihe_aaiii APEdist_oooo No_ligand No_ligand 1 - 284 0 None T162A Serine/threonine-protein kinase Nek1
NEK NEK1 NEK1_HUMAN 4APCB 2.1 Inactive DFGinter‑BABtrans out-out out-out nonTYR APEdihe_aaiii APEdist_oooo No_ligand No_ligand 1 - 284 0 None T162A Serine/threonine-protein kinase Nek1
NEK NEK1 NEK1_HUMAN 4B9DA 1.9 Inactive DFGinter‑BABtrans out-none out-out nonTYR APEdihe_aaiii APEdist_oooo CK7 Type1 1 - 284 0 None T162A Serine/threonine-protein kinase Nek1
NEK NEK1 NEK1_HUMAN 4B9DB 1.9 Inactive DFGinter‑BABtrans out-out out-out nonTYR APEdihe_aaiii APEdist_oooo CK7 Type1 1 - 284 0 None T162A Serine/threonine-protein kinase Nek1
NEK NEK2 NEK2_HUMAN 2W5BA 2.4 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiio APEdist_oooo AGS ATPlike 3 - 271 0 None T175A Serine/threonine-protein kinase Nek2
NEK NEK2 NEK2_HUMAN 2W5HA 2.33 Inactive DFGinter‑None out-none none-out nonTYR APEdihe_aaiio APEdist_iooo No_ligand No_ligand 3 - 271 0 None T175A Serine/threonine-protein kinase Nek2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKH 2.3 Inactive DFGinter‑BABtrans out-out out-out nonTYR APEdihe_aaoni APEdist_oooo G41 Type1 584 - 1006 0 None D848N eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKF 2.3 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoni APEdist_oooo G41 Type1 584 - 1005 0 None D848N eIF-2-alpha kinase GCN2
OTHER IKBKB IKKB_HUMAN 8OMVE 4.16 Inactive DFGinter‑None in-out out-out nonTYR APEdihe_aaooi APEdist_iiio No_ligand No_ligand 9 - 643 0 None S177E,S181E Inhibitor of nuclear factor kappa-B kinase subunit beta
STE MAP2K1 MP2K1_HUMAN 5YT3A 2.9 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanno APEdist_nnnn ANP ATPlike 39 - 382 0 None S218D,S222D,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1
STE MAP3K5 M3K5_HUMAN 2CLQA 2.3 Inactive DFGinter‑BABtrans out-out in-out nonTYR APEdihe_aaiii APEdist_iooi STU Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 2CLQB 2.3 Inactive DFGinter‑BABtrans in-none in-out nonTYR APEdihe_aaiii APEdist_nooi STU Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5
STE MAP4K1 M4K1_HUMAN 9BI8A 2.25 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1APL Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9BI8B 2.25 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1APL Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9N9XA 2.3 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1BWL Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9N9XB 2.3 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1BWL Type1 5 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K4 M4K4_HUMAN 4U3ZA 2.09 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 17 - 311 0 None T181E Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4U3YA 1.45 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 17 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
STE PAK1 PAK1_HUMAN 9D50B 1.898 Inactive DFGinter‑None in-out none-out nonTYR APEdihe_aaiio APEdist_oooo A1A2T Type1 253 - 542 0 None D389N,T423E Serine/threonine-protein kinase PAK 1
STE SLK SLK_HUMAN 4USFA 1.75 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanio APEdist_nnnn 6UI Type1 19 - 310 0 None None STE20-like serine/threonine-protein kinase
STE SLK SLK_HUMAN 4USFB 1.75 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nooi 6UI Type1 19 - 310 0 None None STE20-like serine/threonine-protein kinase
STE STK25 STK25_HUMAN 4NZWB 3.583 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnni J60 Type1 11 - 292 0 None D158A Serine/threonine-protein kinase 25
STE STK26 STK26_HUMAN 4FZFB 3.64 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo DKI Type1 18 - 297 0 None D162A Serine/threonine-protein kinase 26
STE TNIK TNIK_HUMAN 8X88A 2.7 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo No_ligand No_ligand 15 - 311 0 None None TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 8X88B 2.7 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo No_ligand No_ligand 17 - 311 0 None None TRAF2 and NCK-interacting protein kinase
TKL ILK ILK_HUMAN 9D5IA 1.5 Pseudo DFGinter‑None out-out out-out nonTYR APEdihe_aaini APEdist_oioo ATP ATPlike 182 - 452 0 None R225A,C346S,C422S Scaffold protein ILK
TKL ILK ILK_HUMAN 3KMWA 2.0 Pseudo DFGinter‑None out-out out-out nonTYR APEdihe_aaini APEdist_oooo ATP ATPlike 185 - 452 0 None C346S,C422S Scaffold protein ILK
TKL ILK ILK_HUMAN 3REPA 1.8 Pseudo DFGinter‑None out-out out-out nonTYR APEdihe_aaini APEdist_oioo ATP ATPlike 185 - 452 0 None C346S,C422S Scaffold protein ILK
TKL ILK ILK_HUMAN 3KMUA 1.8 Pseudo DFGinter‑None out-out out-out nonTYR APEdihe_aaini APEdist_oooo No_ligand No_ligand 185 - 451 0 None C346S,C422S Scaffold protein ILK
TKL ILK ILK_HUMAN 6MIBA 1.8 Pseudo DFGinter‑None out-out out-out nonTYR APEdihe_aaini APEdist_oooo No_ligand No_ligand 183 - 452 0 None L207W Scaffold protein ILK
TKL ILK ILK_HUMAN 9D5HA 1.5 Pseudo DFGinter‑None out-out out-out nonTYR APEdihe_aaini APEdist_oooo IRE Type1 182 - 452 0 None C346S,R371Q,C422S Scaffold protein ILK
TKL ILK ILK_HUMAN 9D5FA 1.5 Pseudo DFGinter‑None out-out out-out nonTYR APEdihe_aaini APEdist_oooo DB8 Type1 182 - 452 0 None C346S,C422S Scaffold protein ILK
TKL ILK ILK_HUMAN 9D5GAAAA 1.55 Pseudo DFGinter‑None out-out out-out nonTYR APEdihe_aaini APEdist_oioo A1A2V Type1 182 - 452 0 None C346S,C422S Scaffold protein ILK
TKL ILK ILK_HUMAN 9D5PA 1.5 Pseudo DFGinter‑None out-out out-out nonTYR APEdihe_aaini APEdist_oioo AQ4 Type1 182 - 452 0 None C346S,C422S Scaffold protein ILK
TKL ILK ILK_HUMAN 9D5EA 1.5 Pseudo DFGinter‑None out-out out-out nonTYR APEdihe_aaini APEdist_oioo IRE, IRE Type1, Type1 182 - 452 0 None C346S,C422S Scaffold protein ILK
TKL LRRK2 LRRK2_HUMAN 7LHTA 3.5 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 558 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LHTB 3.5 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 558 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LHWA 3.7 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 540 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LI4A 3.1 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 558 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO2E 4.13 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO8C 3.88 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO8E 3.88 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO9F 3.48 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8VH5A 4.0 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioi ANP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8VH5C 4.0 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioi ANP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LI3A 3.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 558 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 9CI3A 3.96 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi No_ligand No_ligand 907 - 2527 0 SEP910,SEP935 None Leucine-rich repeat serine/threonine-protein kinase 2
TKL MAP3K7 M3K7_HUMAN 8GW3B 2.05 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_iooo No_ligand No_ligand 27 - 497 0 None None Mitogen-activated protein kinase kinase kinase 7
TKL MAP3K7 M3K7_HUMAN 8GW3C 2.05 Inactive DFGinter‑None out-none none-out nonTYR APEdihe_aaoii APEdist_iooo No_ligand No_ligand 25 - 497 0 None None Mitogen-activated protein kinase kinase kinase 7
TKL MAP3K7 M3K7_HUMAN 8GW3D 2.05 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaoii APEdist_iioo No_ligand No_ligand 27 - 495 0 None None Mitogen-activated protein kinase kinase kinase 7
TYR ABL1 ABL1_HUMAN 7W7XA 2.0 Inactive DFGinter‑BABtrans in-out out-in TYR APEdihe_iiiai APEdist_aaai 8DW Type1 232 - 500 0 PTR393 None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7W7XB 2.0 Inactive DFGinter‑BABtrans in-out out-in TYR APEdihe_iiiai APEdist_aaai 8DW Type1 232 - 500 0 PTR393 None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 4XEYB 2.891 Inactive DFGinter‑BABtrans in-out out-in TYR APEdihe_iiiai APEdist_aaai 1N1 Type1 122 - 504 0 None None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7N9GA 2.2 Inactive DFGinter‑None in-out out-none TYR APEdihe_nniai APEdist_aaai STI, 1N1 Allosteric, Type1 233 - 498 0 None None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7N9GC 2.2 Inactive DFGinter‑None in-none out-none TYR APEdihe_nniai APEdist_aaai STI, 1N1 Allosteric, Type1 234 - 499 0 None None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2G2FA 2.7 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 232 - 506 0 None H396P Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 6BL8A 2.5 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai PVB Type1 233 - 502 0 None None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 6BL8B 2.5 Inactive DFGinter‑None in-none out-in TYR APEdihe_iiiai APEdist_aaai PVB Type1 233 - 504 0 None None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 8I7SA 1.946 Inactive DFGinter‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai 6CI Type1 232 - 500 0 PTR393 None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 8I7SB 1.946 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 6CI Type1 232 - 500 0 PTR393 None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 8I7ZB 2.255 Inactive DFGinter‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai 6CI Type1 232 - 500 0 PTR393 None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7W7YA 2.2 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 8IW Type1 232 - 500 0 PTR393 None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7W7YB 2.2 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 8IW Type1 232 - 500 0 PTR393 None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 8H7FA 2.45 Inactive DFGinter‑None in-none out-in TYR APEdihe_iiiai APEdist_aaai QEW Type1 232 - 500 0 PTR393 None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 8H7FB 2.45 Inactive DFGinter‑None in-none out-in TYR APEdihe_iiiai APEdist_aaai QEW Type1 233 - 500 0 PTR393 None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 8H7HA 2.278 Inactive DFGinter‑None in-none out-in TYR APEdihe_iiiai APEdist_aaai QH9 Type1 232 - 500 0 PTR393 None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 8H7HB 2.278 Inactive DFGinter‑None in-none out-in TYR APEdihe_iiiai APEdist_aaai QH9 Type1 232 - 500 0 PTR393 None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 4ZOGA 2.3 Inactive DFGinter‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai VX6 Type1 233 - 501 0 None None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7CC2A 2.723 Inactive DFGinter‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai FVC Type1 233 - 501 0 None None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7CC2B 2.723 Inactive DFGinter‑None in-none out-in TYR APEdihe_iiiai APEdist_aaai FVC Type1 232 - 501 0 None None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7DT2A 2.3 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai HJ9 Type1 233 - 500 0 None None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7DT2B 2.3 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai HJ9 Type1 233 - 500 0 None None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2G2HA 2.0 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai P16 Type1 233 - 504 0 None H396P Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 4XEYA 2.891 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 1N1 Type1 231 - 503 0 None None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 8I7ZA 2.255 Inactive DFGinter‑None in-none out-in TYR APEdihe_iiiai APEdist_aaai 6CI, BAL Type1, Type1 232 - 499 0 PTR393 None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 4YC8A 2.9 Inactive DFGinter‑None out-none out-in TYR APEdihe_iiiai APEdist_aaai 4B7 Type1.5_Front 233 - 501 0 None None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 4YC8B 2.9 Inactive DFGinter‑None out-none out-in TYR APEdihe_iiiai APEdist_aaai 4B7 Type1.5_Front 233 - 502 0 None None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 9KS5A 2.2 Inactive DFGinter‑None in-na out-in TYR APEdihe_iiiai APEdist_aaai A1EG1 Type1.5_Front 233 - 500 0 PTR393 None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 9KS5B 2.2 Inactive DFGinter‑None in-na out-in TYR APEdihe_iiiai APEdist_aaai A1EG1 Type1.5_Front 233 - 500 0 PTR393 None Tyrosine-protein kinase ABL1
TYR ABL2 ABL2_HUMAN 3HMIA 1.65 Inactive DFGinter‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai DKI Type1 279 - 546 0 None None Tyrosine-protein kinase ABL2
TYR BMX BMX_HUMAN 3SXRA 2.4 Inactive DFGinter‑BABtrans out-out in-in TYR APEdihe_iiiai APEdist_aaai 1N1 Type1 411 - 671 0 None Q432K,Q611M,D617T,Q620E Cytoplasmic tyrosine-protein kinase BMX
TYR BMX BMX_HUMAN 3SXRB 2.4 Inactive DFGinter‑BABtrans out-out in-in TYR APEdihe_iiiai APEdist_aaai 1N1 Type1 411 - 671 0 None Q432K,Q611M,D617T,Q620E Cytoplasmic tyrosine-protein kinase BMX
TYR BMX BMX_HUMAN 3SXSA 1.89 Inactive DFGinter‑BABtrans out-out in-in TYR APEdihe_iiiai APEdist_aaai PP2 Type1 411 - 671 0 None Q432K,Q611M,D617T,Q620E Cytoplasmic tyrosine-protein kinase BMX
TYR BMX BMX_HUMAN 6I99A 2.001 Inactive DFGinter‑BABtrans out-out in-in TYR APEdihe_iiiai APEdist_aaai H88 Type1 411 - 671 0 None Q432K,Q611M,D617T,Q620E Cytoplasmic tyrosine-protein kinase BMX
TYR BMX BMX_HUMAN 6I99B 2.001 Inactive DFGinter‑BABtrans out-out in-in TYR APEdihe_iiiai APEdist_aaai H88 Type1 411 - 671 0 None Q432K,Q611M,D617T,Q620E Cytoplasmic tyrosine-protein kinase BMX
TYR BTK BTK_HUMAN 5XYZA 2.64 Inactive DFGinter‑BABtrans out-out out-none TYR APEdihe_nniai APEdist_aaai GYL Type1 394 - 656 0 None None Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 5XYZB 2.64 Inactive DFGinter‑BABtrans out-out out-none TYR APEdihe_nniai APEdist_aaai GYL Type1 394 - 656 0 None None Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 7YC9A 1.4 Inactive DFGinter‑BABtrans out-out out-in TYR APEdihe_iiiai APEdist_aaai IS4 Type1 395 - 658 0 None None Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 3OCTA 1.95 Inactive DFGinter‑BABtrans in-out out-none TYR APEdihe_nniai APEdist_aaai 1N1 Type1 394 - 656 0 None V555R Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 6NFIA 2.41 Inactive DFGinter‑None out-out none-out TYR APEdihe_niiai APEdist_aaao KLP Type1 392 - 659 0 None None Tyrosine-protein kinase BTK
TYR CSK CSK_HUMAN 1BYGA 2.4 Inactive DFGinter‑BABtrans out-out none-none TYR APEdihe_nniai APEdist_aaai STU Type1 187 - 448 0 None None Tyrosine-protein kinase CSK
TYR DDR1 DDR1_HUMAN 6Y23A 2.58 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 574 - 907 0 None Y569F,Y586F Epithelial discoidin domain-containing receptor 1
TYR DDR1 DDR1_HUMAN 6Y23B 2.58 Inactive DFGinter‑None in-out out-none TYR APEdihe_niiai APEdist_aaai No_ligand No_ligand 574 - 910 0 None Y569F,Y586F Epithelial discoidin domain-containing receptor 1
TYR DDR1 DDR1_HUMAN 6Y23C 2.58 Inactive DFGinter‑None in-out out-none TYR APEdihe_niiai APEdist_aaai No_ligand No_ligand 574 - 911 0 None Y569F,Y586F Epithelial discoidin domain-containing receptor 1
TYR DDR1 DDR1_HUMAN 6BRJA 2.231 Inactive DFGinter‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai VX6 Type1 605 - 913 0 None None Epithelial discoidin domain-containing receptor 1
TYR DDR1 DDR1_HUMAN 6BSDA 2.606 Inactive DFGinter‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai 1N1 Type1 604 - 912 0 None None Epithelial discoidin domain-containing receptor 1
TYR EGFR EGFR_HUMAN 8H7XB 3.404 Inactive DFGinter‑None in-in out-none TYR APEdihe_nniai APEdist_aaai No_ligand No_ligand 697 - 1018 0 None T790M,C797S Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5XGNB 3.0 Inactive DFGinter‑None in-in out-out TYR APEdihe_oiiai APEdist_aaai No_ligand No_ligand 697 - 1019 0 None T790M,C797S Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2JITB 3.1 Inactive DFGinter‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 697 - 1018 0 None T790M Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2JIUB 3.05 Inactive DFGinter‑None in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 695 - 1004 0 None T790M Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4G5PB 3.17 Inactive DFGinter‑None in-in out-out TYR APEdihe_niiai APEdist_aaao No_ligand No_ligand 697 - 1018 0 None T790M Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3IKAB 2.9 Inactive DFGinter‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 697 - 1017 0 None T790M Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4WD5B 3.3 Inactive DFGinter‑None in-out out-out TYR APEdihe_iiiai APEdist_aaao No_ligand No_ligand 697 - 1016 0 None T790M Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5UWDA 3.06 Inactive DFGinter‑None out-out out-out TYR APEdihe_niiai APEdist_aaao 8OV Type1 702 - 984 0 None T790M,L858R,V948R Epidermal growth factor receptor
TYR IGF1R IGF1R_HUMAN 1M7NA 2.7 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 982 - 1286 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 1M7NB 2.7 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 982 - 1286 0 None None Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 1P4OA 1.5 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 978 - 1285 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 1P4OB 1.5 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 977 - 1290 0 None E1097A,E1099A Insulin-like growth factor 1 receptor
TYR KDR VGFR2_HUMAN 1Y6AA 2.1 Inactive DFGinter‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan AAZ Type1 820 - 1167 0 None None Vascular endothelial growth factor receptor 2
TYR KDR VGFR2_HUMAN 1Y6BA 2.1 Inactive DFGinter‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan AAX Type1 819 - 1168 0 None None Vascular endothelial growth factor receptor 2
TYR PTK2 FAK1_HUMAN 4EBWA 2.65 Inactive DFGinter‑None in-in none-out TYR APEdihe_niiai APEdist_aaao 0PF Type1 411 - 686 0 None None Focal adhesion kinase 1
TYR ROR2 ROR2_HUMAN 3ZZWA 2.9 Pseudo DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 466 - 750 0 None None Tyrosine-protein kinase transmembrane receptor ROR2
TYR ROR2 ROR2_HUMAN 4GT4A 2.406 Pseudo DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 464 - 751 0 None None Tyrosine-protein kinase transmembrane receptor ROR2
TYR ROR2 ROR2_HUMAN 4GT4B 2.406 Pseudo DFGinter‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 464 - 752 0 None None Tyrosine-protein kinase transmembrane receptor ROR2
TYR SRC SRC_HUMAN 4MXXB 2.6 Inactive DFGinter‑BABtrans out-out none-none TYR APEdihe_nniai APEdist_aaai DB8 Type1 261 - 536 0 None A406T Proto-oncogene tyrosine-protein kinase Src
TYR TEK TIE2_HUMAN 1FVRA 2.2 Inactive DFGinter‑BABtrans out-out out-out TYR APEdihe_nniai APEdist_aaao No_ligand No_ligand 813 - 1121 0 None None Angiopoietin-1 receptor
TYR TEK TIE2_HUMAN 1FVRB 2.2 Inactive DFGinter‑BABtrans out-out out-out TYR APEdihe_niiai APEdist_aaao No_ligand No_ligand 813 - 1121 0 None None Angiopoietin-1 receptor

All / DFGinter / All

Total number of chains: 255
Active chains: 0
Total number of genes: 52
Spatial label Dihedral label Number of Chains Percent Representative
DFGinter None 229 89.8% 4U3YA
DFGinter BABtrans 26 10.2% 7YC9A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CAMK SRK2E SRK2E_ARATH 3UJGA 2.6 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo No_ligand No_ligand 20 - 318 0 None D296A,E297A Serine/threonine-protein kinase SRK2E Arabidopsis thaliana
CAMK SRK2E SRK2E_ARATH 3UDBA 2.567 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 12 - 317 0 None S7A,S29A,S43A,C131A,C137A,C159A,S166A,T176A Serine/threonine-protein kinase SRK2E Arabidopsis thaliana
CAMK SRK2E SRK2E_ARATH 3UDBB 2.567 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 12 - 317 0 None S7A,S29A,S43A,C131A,C137A,C159A,S166A,T176A Serine/threonine-protein kinase SRK2E Arabidopsis thaliana
CAMK SRK2E SRK2E_ARATH 3UDBD 2.567 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 12 - 317 0 None S7A,S29A,S43A,C131A,C137A,C159A,S166A,T176A Serine/threonine-protein kinase SRK2E Arabidopsis thaliana
CAMK SRK2E SRK2E_ARATH 3UDBF 2.567 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 12 - 317 0 None S7A,S29A,S43A,C131A,C137A,C159A,S166A,T176A Serine/threonine-protein kinase SRK2E Arabidopsis thaliana
CAMK SRK2E SRK2E_ARATH 3UC4A 2.3 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaiii APEdist_nioo No_ligand No_ligand 12 - 318 0 None D59A,E60A Serine/threonine-protein kinase SRK2E Arabidopsis thaliana
CAMK SRK2E SRK2E_ARATH 3UC4B 2.3 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 12 - 317 0 None D59A,E60A Serine/threonine-protein kinase SRK2E Arabidopsis thaliana
AGC GRK1 GRK1_BOVIN 3C4YB 7.509 Inactive DFGinter‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 30 - 532 0 None None Rhodopsin kinase GRK1 Bos taurus
OTHER PKNG Q8NM29_CORGL 7MXJA 1.92 Inactive DFGinter‑None out-out in-out nonTYR APEdihe_aaiii APEdist_ioii MAP Type1 62 - 358 0 None None non-specific serine/threonine protein kinase Corynebacterium glutamicum
OTHER PKNG Q8NM29_CORGL 7MXKA 1.99 Inactive DFGinter‑None out-out in-out nonTYR APEdihe_aaiii APEdist_ioii MAP Type1 63 - 360 0 None None non-specific serine/threonine protein kinase Corynebacterium glutamicum
OTHER PKNG Q8NM29_CORGL 7MXBB 2.2 Inactive DFGinter‑None out-out in-in nonTYR APEdihe_aaiii APEdist_iiii MAP Type1 54 - 727 0 None None non-specific serine/threonine protein kinase Corynebacterium glutamicum
TYR SRC SRC_CHICK 2QQ7B 2.38 Inactive DFGinter‑None none-none none-none TYR APEdihe_nnnai APEdist_aaan SR2 Type1 258 - 533 0 None T338M,S345C Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3LOKB 2.48 Inactive DFGinter‑None none-none none-none TYR APEdihe_nnnai APEdist_aaan DJK Type1 258 - 533 0 None T338M,S345C Proto-oncogene tyrosine-protein kinase Src Gallus gallus
AGC ROCK1 ROCK1_HUMAN 3TWJB 2.9 Inactive DFGinter‑None in-in out-out nonTYR APEdihe_aaioi APEdist_iioi No_ligand No_ligand 8 - 402 0 None None Rho-associated protein kinase 1 Homo sapiens
AGC ROCK1 ROCK1_HUMAN 3TWJD 2.9 Inactive DFGinter‑None in-in out-out nonTYR APEdihe_aaioi APEdist_iioi No_ligand No_ligand 8 - 402 0 None None Rho-associated protein kinase 1 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOC 2.75 Inactive DFGinter‑None none-none out-out nonTYR APEdihe_aaioi APEdist_oooo ANP ATPlike 46 - 347 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOG 2.75 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanni APEdist_oonn ANP ATPlike 46 - 348 0 None None Ribosomal protein S6 kinase alpha-3 Homo sapiens
AGC RPS6KA5-1 KS6A5_HUMAN 1VZOA 1.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iooo No_ligand No_ligand 24 - 345 0 None S212D Ribosomal protein S6 kinase alpha-5 Homo sapiens
AGC RPS6KA6-1 KS6A6_HUMAN 6G76B 3.0 Inactive DFGinter‑None none-none out-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 51 - 349 0 SEP232 None Ribosomal protein S6 kinase alpha-6 Homo sapiens
AGC RPS6KA6-1 KS6A6_HUMAN 6G78A 2.5 Inactive DFGinter‑None none-none out-out nonTYR APEdihe_aaoii APEdist_nnno ANP ATPlike 51 - 349 0 None S232E Ribosomal protein S6 kinase alpha-6 Homo sapiens
AGC RPS6KA6-1 KS6A6_HUMAN 6G78B 2.5 Inactive DFGinter‑None none-none out-out nonTYR APEdihe_aaiii APEdist_nnno ANP ATPlike 51 - 349 0 None S232E Ribosomal protein S6 kinase alpha-6 Homo sapiens
AGC RPS6KA6-1 KS6A6_HUMAN 6G76A 3.0 Inactive DFGinter‑None none-none out-out nonTYR APEdihe_aaiii APEdist_iooi ANP, ANP ATPlike, Allosteric 51 - 349 0 SEP232 None Ribosomal protein S6 kinase alpha-6 Homo sapiens
AGC SGK1 SGK1_HUMAN 2R5TA 1.9 Inactive DFGinter‑None none-none out-out nonTYR APEdihe_aaiio APEdist_oooo ANP ATPlike 82 - 378 0 None S74A,S78A,S397A,S401A Serine/threonine-protein kinase Sgk1 Homo sapiens
AGC SGK1 SGK1_HUMAN 3HDMA 2.6 Inactive DFGinter‑None none-none out-out nonTYR APEdihe_aaiio APEdist_oooo MMG Type1 81 - 378 0 None S74A,S78A,S397A,S401A Serine/threonine-protein kinase Sgk1 Homo sapiens
AGC SGK1 SGK1_HUMAN 3HDNA 3.1 Inactive DFGinter‑None none-none out-out nonTYR APEdihe_aaiio APEdist_oooo GMG Type1 82 - 374 0 None S74A,S78A,S397A,S401A Serine/threonine-protein kinase Sgk1 Homo sapiens
CAMK AURKA AURKA_HUMAN 4C3RA 2.79 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno ACP ATPlike 127 - 388 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 6C83B 2.55 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnno ACP ATPlike 127 - 388 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5L8JA 1.68 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn ADP ATPlike 126 - 391 0 TPO288 C290A,C393A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5L8KA 1.79 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ADP ATPlike 126 - 392 0 TPO288 C290A,C393A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5L8LA 1.67 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_iooo ADP ATPlike 126 - 389 0 TPO288 C290A,C393A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 8PR7A 2.76 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnno ADP ATPlike 124 - 389 0 None D274N,C290A,N332A,Q335A,T347A,D350A,C393A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 6XKAA 2.65 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_nnno No_ligand No_ligand 127 - 388 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 2WTVA 2.4 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_iioo ZZL Type1 125 - 389 0 TPO287,TPO288 L215R,T217E,R220K Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 2WTVB 2.4 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ZZL Type1 126 - 389 0 TPO287,TPO288 L215R,T217E,R220K Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 2WTVC 2.4 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo ZZL Type1 126 - 389 0 TPO287,TPO288 L215R,T217E,R220K Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 2WTVD 2.4 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_iioo ZZL Type1 125 - 389 0 TPO287,TPO288 L215R,T217E,R220K Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 5EW9A 2.181 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioo 5VC Type1 127 - 390 0 TPO287,TPO288 None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 6C2RA 1.96 Inactive DFGinter‑None out-none out-out nonTYR APEdihe_aanoi APEdist_nnnn EG7 Type1 128 - 389 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 6C2TA 1.73 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo EGJ Type1 128 - 388 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3W16A 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioo APEdist_nnno P9J Type1 126 - 388 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 2J50A 3.0 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_oooo 627 Type1 128 - 389 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 2J50B 3.0 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_oooo 627 Type1 128 - 389 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 4ZTRA 2.85 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno 4RJ Type1 127 - 388 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 6Z4YA 2.25 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo Q7Q Type1 124 - 389 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 6CPGA 2.8 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaoni APEdist_nnoo 35R Type1 127 - 387 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 6CPGD 2.8 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nooo 35R Type1 127 - 388 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 8SSOA 1.97 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_nooo 627 Type1 127 - 389 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 8SSOD 1.97 Inactive DFGinter‑None out-out out-none nonTYR APEdihe_aanii APEdist_nnnn 627 Type1 127 - 389 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 1MUOA 2.9 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaoii APEdist_nooo ADN Type1 128 - 388 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 2J4ZA 2.0 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oioo 626 Type1 126 - 389 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3UNZA 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0BZ Type1 127 - 389 0 None T287D Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3UNZB 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0BZ Type1 127 - 389 0 None T287D Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3UO6A 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0BY Type1 126 - 389 0 None T287D Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3UO6B 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0BY Type1 126 - 389 0 None T287D Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3UOHA 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C4 Type1 126 - 389 0 None T287D Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3UOHB 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C4 Type1 126 - 389 0 None T287D Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3UOJA 2.9 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C5 Type1 127 - 389 0 None T287D Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3UOJB 2.9 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C5 Type1 127 - 389 0 None T287D Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3UOKA 2.951 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C6 Type1 125 - 389 0 None T287D Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3UOKB 2.951 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C6 Type1 125 - 389 0 None T287D Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3UOLA 2.4 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C7 Type1 127 - 389 0 None T287D Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3UOLB 2.4 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oioo 0C7 Type1 127 - 389 0 None T287D Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3FDNA 1.9 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo MMH Type1 126 - 394 0 None T288D Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3K5UA 2.35 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo PFQ Type1 126 - 394 0 None T288D Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 4JBQA 2.3 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo VX6 Type1 126 - 391 0 None T288D Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3LAUA 2.1 Inactive DFGinter‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn OFI Type1 125 - 391 0 None T288D Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 4UZHA 2.0 Inactive DFGinter‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn JVE Type1 125 - 392 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3H0YA 2.5 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 48B Type1 126 - 388 0 None K124A,T287A,T288A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3H10A 2.2 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iooo 97B Type1 124 - 391 0 None K124A,T287A,T288A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3H10B 2.2 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iooo 97B Type1 125 - 391 0 None K124A,T287A,T288A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3H10D 2.2 Inactive DFGinter‑None out-out out-none nonTYR APEdihe_aanii APEdist_nnnn 97B Type1 126 - 388 0 None K124A,T287A,T288A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3P9JA 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno P9J Type1 126 - 388 0 None T287A,T288A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3W10A 2.7 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_iooo RO9 Type1 126 - 388 0 None T287A,T288A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3R22A 2.9 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno D37 Type1 126 - 389 0 None T287D,T288D Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 9KDSA 2.5 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnno A1EFT Type1 126 - 391 0 None C290A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 2BMCA 2.6 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn MPY Type1 127 - 394 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 2BMCB 2.6 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn MPY Type1 125 - 394 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 2BMCC 2.6 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn MPY Type1 125 - 393 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 2BMCD 2.6 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn MPY Type1 127 - 394 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 2BMCE 2.6 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn MPY Type1 127 - 394 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 2BMCF 2.6 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn MPY Type1 126 - 394 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 7FICA 2.32 Inactive DFGinter‑None out-none none-out nonTYR APEdihe_aaooi APEdist_nnoo 5YZ Type1 127 - 391 0 None C290A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 9BZGA 1.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_iioo OG0 Type1 127 - 388 0 TPO288 C290A,C393S Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 9BZLB 1.81 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_iioo OGR Type1 127 - 388 0 TPO288 C290A,C393S Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 9KS6A 2.75 Inactive DFGinter‑None out-na none-none nonTYR APEdihe_aanii APEdist_nnnn A1EG1 Type1 127 - 391 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 4ZTQA 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno 4RM Type1.5_Back 127 - 388 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 4ZTSA 2.9 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn 4RK Type1.5_Back 127 - 388 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3EFWA 2.29 Inactive DFGinter‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn AK8 Type1.5_Front 126 - 388 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3EFWB 2.29 Inactive DFGinter‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn AK8 Type1.5_Front 126 - 389 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3O50A 2.0 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn LJE Type1.5_Front 126 - 388 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3O50B 2.0 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno LJE Type1.5_Front 126 - 389 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 6HJJA 2.13 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnno G7T Type1.5_Front 127 - 393 0 None L210C,C290A,C393A Aurora kinase A Homo sapiens
CAMK AURKB AURKB_HUMAN 4AF3A 2.75 Inactive DFGinter‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn VX6 Type1 70 - 338 0 None None Aurora kinase B Homo sapiens
CAMK CAMK1 KCC1A_HUMAN 4FG9A 2.4 Inactive DFGinter‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn ATP ATPlike 10 - 314 0 None None Calcium/calmodulin-dependent protein kinase type 1 Homo sapiens
CAMK CAMK1 KCC1A_HUMAN 4FG9B 2.4 Inactive DFGinter‑None out-none none-out nonTYR APEdihe_aaini APEdist_nnno ATP ATPlike 14 - 314 0 None None Calcium/calmodulin-dependent protein kinase type 1 Homo sapiens
CAMK CAMK1 KCC1A_HUMAN 4FGBA 2.6 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iooo No_ligand No_ligand 10 - 299 0 None None Calcium/calmodulin-dependent protein kinase type 1 Homo sapiens
CAMK CAMK1D KCC1D_HUMAN 6T6FA 1.97 Inactive DFGinter‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn MMW Type1 12 - 329 0 None None Calcium/calmodulin-dependent protein kinase type 1D Homo sapiens
CAMK CAMK1D KCC1D_HUMAN 6T6FB 1.97 Inactive DFGinter‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn MMW Type1 12 - 329 0 None None Calcium/calmodulin-dependent protein kinase type 1D Homo sapiens
CAMK CAMK1D KCC1D_HUMAN 6T29AAA 1.484 Inactive DFGinter‑None out-out none-none nonTYR APEdihe_aannn APEdist_nnnn M8Z Type1 12 - 302 0 None None Calcium/calmodulin-dependent protein kinase type 1D Homo sapiens
CAMK CAMK2A KCC2A_HUMAN 6W4OO 4.8 Inactive DFGinter‑None in-na in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 7 - 301 0 None K42M Calcium/calmodulin-dependent protein kinase type II subunit alpha Homo sapiens
CAMK CAMK2A KCC2A_HUMAN 6W4PH 6.6 Inactive DFGinter‑None in-na in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 7 - 301 0 None K42M Calcium/calmodulin-dependent protein kinase type II subunit alpha Homo sapiens
CAMK CAMK2A KCC2A_HUMAN 3SOAA 3.55 Inactive DFGinter‑None in-na in-in nonTYR APEdihe_aaiii APEdist_iiii DB8 Type1 7 - 474 0 None K42M,D135N,T306V Calcium/calmodulin-dependent protein kinase type II subunit alpha Homo sapiens
CAMK MELK MELK_HUMAN 4IXPA 2.749 Inactive DFGinter‑BABtrans out-none out-out nonTYR APEdihe_aaoii APEdist_oooo No_ligand No_ligand 2 - 335 0 None K40R,D150A Maternal embryonic leucine zipper kinase Homo sapiens
CAMK MELK MELK_HUMAN 4UMTA 1.98 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnoo 47W Type1 3 - 333 0 None N213T,V214A,M215A,Y218V,K219A Maternal embryonic leucine zipper kinase Homo sapiens
CAMK MELK MELK_HUMAN 4UMUA 2.02 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnoo 0V0 Type1 3 - 333 0 None None Maternal embryonic leucine zipper kinase Homo sapiens
CAMK PRKAA1 AAPK1_HUMAN 4REDA 2.95 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoo APEdist_nnnn No_ligand No_ligand 22 - 360 0 None K52A 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens
CAMK PRKAA1 AAPK1_HUMAN 4REDB 2.95 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 22 - 360 0 None K52A 5'-AMP-activated protein kinase catalytic subunit alpha-1 Homo sapiens
CAMK TRIB1 TRIB1_HUMAN 5CEKA 2.8 Pseudo DFGinter‑None out-na none-out nonTYR APEdihe_aanao APEdist_nnnn No_ligand No_ligand 88 - 342 0 None None Tribbles homolog 1 Homo sapiens
CAMK TRIB1 TRIB1_HUMAN 5CEMA 2.1 Pseudo DFGinter‑None out-na none-out nonTYR APEdihe_aaiao APEdist_oooo No_ligand No_ligand 88 - 364 0 None None Tribbles homolog 1 Homo sapiens
CMGC MAPK14 MK14_HUMAN 4EH9A 2.1 Inactive DFGinter‑None in-out none-out nonTYR APEdihe_aaoii APEdist_nnoo IRG, 0OQ Allosteric, Type3 5 - 354 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3GCPA 2.25 Inactive DFGinter‑None in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn SB2 Type1 4 - 352 0 None C119S,C162S,A172C,F327L Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 5WJJA 1.6 Inactive DFGinter‑None in-in out-out nonTYR APEdihe_aaoii APEdist_nnno AQY Type1 5 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 6ANLA 2.0 Inactive DFGinter‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno T75 Type1 4 - 352 0 None C119S,C162S Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 5ML5A 1.9 Inactive DFGinter‑None in-in none-none nonTYR APEdihe_aanii APEdist_nnnn 1VI Type1 5 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3HUCA 1.8 Inactive DFGinter‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno G97 Type1 4 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3ZS5A 1.6 Inactive DFGinter‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno SB2 Type1 2 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3ZSGA 1.89 Inactive DFGinter‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno T75 Type1 4 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 6HWTA 1.7 Inactive DFGinter‑None in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn GXH Type1 5 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 6HWUA 2.3 Inactive DFGinter‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnoo GE5 Type1 5 - 353 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 6HWVA 1.7 Inactive DFGinter‑None in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn GEW Type1 5 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 4EHVA 1.6 Inactive DFGinter‑None in-none none-out nonTYR APEdihe_aaoii APEdist_nnoo 0SJ, 0SJ, IRG, 0SJ Type3, Allosteric, Allosteric, Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK6 MK06_HUMAN 6YKYA 2.52 Inactive DFGinter‑None in-out out-out nonTYR APEdihe_aaioi APEdist_oooo OWQ Type1 18 - 319 0 None L290V Mitogen-activated protein kinase 6 Homo sapiens
CMGC MAPK6 MK06_HUMAN 6YKYD 2.52 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo OWQ Type1 14 - 321 0 None L290V Mitogen-activated protein kinase 6 Homo sapiens
CMGC MAPK6 MK06_HUMAN 6YLCD 2.43 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo OXW Type1 13 - 321 0 None L290V Mitogen-activated protein kinase 6 Homo sapiens
NEK NEK1 NEK1_HUMAN 4APCA 2.1 Inactive DFGinter‑BABtrans out-none out-out nonTYR APEdihe_aaiii APEdist_oooo No_ligand No_ligand 1 - 284 0 None T162A Serine/threonine-protein kinase Nek1 Homo sapiens
NEK NEK1 NEK1_HUMAN 4APCB 2.1 Inactive DFGinter‑BABtrans out-out out-out nonTYR APEdihe_aaiii APEdist_oooo No_ligand No_ligand 1 - 284 0 None T162A Serine/threonine-protein kinase Nek1 Homo sapiens
NEK NEK1 NEK1_HUMAN 4B9DA 1.9 Inactive DFGinter‑BABtrans out-none out-out nonTYR APEdihe_aaiii APEdist_oooo CK7 Type1 1 - 284 0 None T162A Serine/threonine-protein kinase Nek1 Homo sapiens
NEK NEK1 NEK1_HUMAN 4B9DB 1.9 Inactive DFGinter‑BABtrans out-out out-out nonTYR APEdihe_aaiii APEdist_oooo CK7 Type1 1 - 284 0 None T162A Serine/threonine-protein kinase Nek1 Homo sapiens
NEK NEK2 NEK2_HUMAN 2W5BA 2.4 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiio APEdist_oooo AGS ATPlike 3 - 271 0 None T175A Serine/threonine-protein kinase Nek2 Homo sapiens
NEK NEK2 NEK2_HUMAN 2W5HA 2.33 Inactive DFGinter‑None out-none none-out nonTYR APEdihe_aaiio APEdist_iooo No_ligand No_ligand 3 - 271 0 None T175A Serine/threonine-protein kinase Nek2 Homo sapiens
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKH 2.3 Inactive DFGinter‑BABtrans out-out out-out nonTYR APEdihe_aaoni APEdist_oooo G41 Type1 584 - 1006 0 None D848N eIF-2-alpha kinase GCN2 Homo sapiens
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKF 2.3 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoni APEdist_oooo G41 Type1 584 - 1005 0 None D848N eIF-2-alpha kinase GCN2 Homo sapiens
OTHER IKBKB IKKB_HUMAN 8OMVE 4.16 Inactive DFGinter‑None in-out out-out nonTYR APEdihe_aaooi APEdist_iiio No_ligand No_ligand 9 - 643 0 None S177E,S181E Inhibitor of nuclear factor kappa-B kinase subunit beta Homo sapiens
STE MAP2K1 MP2K1_HUMAN 5YT3A 2.9 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanno APEdist_nnnn ANP ATPlike 39 - 382 0 None S218D,S222D,T292A,S298A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP3K5 M3K5_HUMAN 2CLQA 2.3 Inactive DFGinter‑BABtrans out-out in-out nonTYR APEdihe_aaiii APEdist_iooi STU Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 2CLQB 2.3 Inactive DFGinter‑BABtrans in-none in-out nonTYR APEdihe_aaiii APEdist_nooi STU Type1 670 - 940 0 None None Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9BI8A 2.25 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1APL Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9BI8B 2.25 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1APL Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9N9XA 2.3 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1BWL Type1 6 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9N9XB 2.3 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo A1BWL Type1 5 - 293 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4U3ZA 2.09 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 17 - 311 0 None T181E Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE MAP4K4 M4K4_HUMAN 4U3YA 1.45 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 17 - 311 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
STE PAK1 PAK1_HUMAN 9D50B 1.898 Inactive DFGinter‑None in-out none-out nonTYR APEdihe_aaiio APEdist_oooo A1A2T Type1 253 - 542 0 None D389N,T423E Serine/threonine-protein kinase PAK 1 Homo sapiens
STE SLK SLK_HUMAN 4USFA 1.75 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aanio APEdist_nnnn 6UI Type1 19 - 310 0 None None STE20-like serine/threonine-protein kinase Homo sapiens
STE SLK SLK_HUMAN 4USFB 1.75 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nooi 6UI Type1 19 - 310 0 None None STE20-like serine/threonine-protein kinase Homo sapiens
STE STK25 STK25_HUMAN 4NZWB 3.583 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaooi APEdist_nnni J60 Type1 11 - 292 0 None D158A Serine/threonine-protein kinase 25 Homo sapiens
STE STK26 STK26_HUMAN 4FZFB 3.64 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo DKI Type1 18 - 297 0 None D162A Serine/threonine-protein kinase 26 Homo sapiens
STE TNIK TNIK_HUMAN 8X88A 2.7 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_nnoo No_ligand No_ligand 15 - 311 0 None None TRAF2 and NCK-interacting protein kinase Homo sapiens
STE TNIK TNIK_HUMAN 8X88B 2.7 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaooi APEdist_oooo No_ligand No_ligand 17 - 311 0 None None TRAF2 and NCK-interacting protein kinase Homo sapiens
TKL ILK ILK_HUMAN 9D5IA 1.5 Pseudo DFGinter‑None out-out out-out nonTYR APEdihe_aaini APEdist_oioo ATP ATPlike 182 - 452 0 None R225A,C346S,C422S Scaffold protein ILK Homo sapiens
TKL ILK ILK_HUMAN 3KMWA 2.0 Pseudo DFGinter‑None out-out out-out nonTYR APEdihe_aaini APEdist_oooo ATP ATPlike 185 - 452 0 None C346S,C422S Scaffold protein ILK Homo sapiens
TKL ILK ILK_HUMAN 3REPA 1.8 Pseudo DFGinter‑None out-out out-out nonTYR APEdihe_aaini APEdist_oioo ATP ATPlike 185 - 452 0 None C346S,C422S Scaffold protein ILK Homo sapiens
TKL ILK ILK_HUMAN 3KMUA 1.8 Pseudo DFGinter‑None out-out out-out nonTYR APEdihe_aaini APEdist_oooo No_ligand No_ligand 185 - 451 0 None C346S,C422S Scaffold protein ILK Homo sapiens
TKL ILK ILK_HUMAN 6MIBA 1.8 Pseudo DFGinter‑None out-out out-out nonTYR APEdihe_aaini APEdist_oooo No_ligand No_ligand 183 - 452 0 None L207W Scaffold protein ILK Homo sapiens
TKL ILK ILK_HUMAN 9D5HA 1.5 Pseudo DFGinter‑None out-out out-out nonTYR APEdihe_aaini APEdist_oooo IRE Type1 182 - 452 0 None C346S,R371Q,C422S Scaffold protein ILK Homo sapiens
TKL ILK ILK_HUMAN 9D5FA 1.5 Pseudo DFGinter‑None out-out out-out nonTYR APEdihe_aaini APEdist_oooo DB8 Type1 182 - 452 0 None C346S,C422S Scaffold protein ILK Homo sapiens
TKL ILK ILK_HUMAN 9D5GAAAA 1.55 Pseudo DFGinter‑None out-out out-out nonTYR APEdihe_aaini APEdist_oioo A1A2V Type1 182 - 452 0 None C346S,C422S Scaffold protein ILK Homo sapiens
TKL ILK ILK_HUMAN 9D5PA 1.5 Pseudo DFGinter‑None out-out out-out nonTYR APEdihe_aaini APEdist_oioo AQ4 Type1 182 - 452 0 None C346S,C422S Scaffold protein ILK Homo sapiens
TKL ILK ILK_HUMAN 9D5EA 1.5 Pseudo DFGinter‑None out-out out-out nonTYR APEdihe_aaini APEdist_oioo IRE, IRE Type1, Type1 182 - 452 0 None C346S,C422S Scaffold protein ILK Homo sapiens
TKL LRRK2 LRRK2_HUMAN 7LHTA 3.5 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 558 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 7LHTB 3.5 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 558 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 7LHWA 3.7 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 540 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 7LI4A 3.1 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 558 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 8FO2E 4.13 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 8FO8C 3.88 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 8FO8E 3.88 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 8FO9F 3.48 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 8VH5A 4.0 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioi ANP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 8VH5C 4.0 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioi ANP ATPlike 12 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 7LI3A 3.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi ATP ATPlike 558 - 2527 0 None None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL LRRK2 LRRK2_HUMAN 9CI3A 3.96 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioi No_ligand No_ligand 907 - 2527 0 SEP910,SEP935 None Leucine-rich repeat serine/threonine-protein kinase 2 Homo sapiens
TKL MAP3K7 M3K7_HUMAN 8GW3B 2.05 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaoii APEdist_iooo No_ligand No_ligand 27 - 497 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
TKL MAP3K7 M3K7_HUMAN 8GW3C 2.05 Inactive DFGinter‑None out-none none-out nonTYR APEdihe_aaoii APEdist_iooo No_ligand No_ligand 25 - 497 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
TKL MAP3K7 M3K7_HUMAN 8GW3D 2.05 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaoii APEdist_iioo No_ligand No_ligand 27 - 495 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
TYR ABL1 ABL1_HUMAN 7W7XA 2.0 Inactive DFGinter‑BABtrans in-out out-in TYR APEdihe_iiiai APEdist_aaai 8DW Type1 232 - 500 0 PTR393 None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 7W7XB 2.0 Inactive DFGinter‑BABtrans in-out out-in TYR APEdihe_iiiai APEdist_aaai 8DW Type1 232 - 500 0 PTR393 None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 4XEYB 2.891 Inactive DFGinter‑BABtrans in-out out-in TYR APEdihe_iiiai APEdist_aaai 1N1 Type1 122 - 504 0 None None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 7N9GA 2.2 Inactive DFGinter‑None in-out out-none TYR APEdihe_nniai APEdist_aaai STI, 1N1 Allosteric, Type1 233 - 498 0 None None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 7N9GC 2.2 Inactive DFGinter‑None in-none out-none TYR APEdihe_nniai APEdist_aaai STI, 1N1 Allosteric, Type1 234 - 499 0 None None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 2G2FA 2.7 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 232 - 506 0 None H396P Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 6BL8A 2.5 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai PVB Type1 233 - 502 0 None None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 6BL8B 2.5 Inactive DFGinter‑None in-none out-in TYR APEdihe_iiiai APEdist_aaai PVB Type1 233 - 504 0 None None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 8I7SA 1.946 Inactive DFGinter‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai 6CI Type1 232 - 500 0 PTR393 None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 8I7SB 1.946 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 6CI Type1 232 - 500 0 PTR393 None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 8I7ZB 2.255 Inactive DFGinter‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai 6CI Type1 232 - 500 0 PTR393 None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 7W7YA 2.2 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 8IW Type1 232 - 500 0 PTR393 None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 7W7YB 2.2 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 8IW Type1 232 - 500 0 PTR393 None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 8H7FA 2.45 Inactive DFGinter‑None in-none out-in TYR APEdihe_iiiai APEdist_aaai QEW Type1 232 - 500 0 PTR393 None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 8H7FB 2.45 Inactive DFGinter‑None in-none out-in TYR APEdihe_iiiai APEdist_aaai QEW Type1 233 - 500 0 PTR393 None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 8H7HA 2.278 Inactive DFGinter‑None in-none out-in TYR APEdihe_iiiai APEdist_aaai QH9 Type1 232 - 500 0 PTR393 None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 8H7HB 2.278 Inactive DFGinter‑None in-none out-in TYR APEdihe_iiiai APEdist_aaai QH9 Type1 232 - 500 0 PTR393 None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 4ZOGA 2.3 Inactive DFGinter‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai VX6 Type1 233 - 501 0 None None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 7CC2A 2.723 Inactive DFGinter‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai FVC Type1 233 - 501 0 None None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 7CC2B 2.723 Inactive DFGinter‑None in-none out-in TYR APEdihe_iiiai APEdist_aaai FVC Type1 232 - 501 0 None None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 7DT2A 2.3 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai HJ9 Type1 233 - 500 0 None None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 7DT2B 2.3 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai HJ9 Type1 233 - 500 0 None None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 2G2HA 2.0 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai P16 Type1 233 - 504 0 None H396P Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 4XEYA 2.891 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai 1N1 Type1 231 - 503 0 None None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 8I7ZA 2.255 Inactive DFGinter‑None in-none out-in TYR APEdihe_iiiai APEdist_aaai 6CI, BAL Type1, Type1 232 - 499 0 PTR393 None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 4YC8A 2.9 Inactive DFGinter‑None out-none out-in TYR APEdihe_iiiai APEdist_aaai 4B7 Type1.5_Front 233 - 501 0 None None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 4YC8B 2.9 Inactive DFGinter‑None out-none out-in TYR APEdihe_iiiai APEdist_aaai 4B7 Type1.5_Front 233 - 502 0 None None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 9KS5A 2.2 Inactive DFGinter‑None in-na out-in TYR APEdihe_iiiai APEdist_aaai A1EG1 Type1.5_Front 233 - 500 0 PTR393 None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 9KS5B 2.2 Inactive DFGinter‑None in-na out-in TYR APEdihe_iiiai APEdist_aaai A1EG1 Type1.5_Front 233 - 500 0 PTR393 None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL2 ABL2_HUMAN 3HMIA 1.65 Inactive DFGinter‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai DKI Type1 279 - 546 0 None None Tyrosine-protein kinase ABL2 Homo sapiens
TYR BMX BMX_HUMAN 3SXRA 2.4 Inactive DFGinter‑BABtrans out-out in-in TYR APEdihe_iiiai APEdist_aaai 1N1 Type1 411 - 671 0 None Q432K,Q611M,D617T,Q620E Cytoplasmic tyrosine-protein kinase BMX Homo sapiens
TYR BMX BMX_HUMAN 3SXRB 2.4 Inactive DFGinter‑BABtrans out-out in-in TYR APEdihe_iiiai APEdist_aaai 1N1 Type1 411 - 671 0 None Q432K,Q611M,D617T,Q620E Cytoplasmic tyrosine-protein kinase BMX Homo sapiens
TYR BMX BMX_HUMAN 3SXSA 1.89 Inactive DFGinter‑BABtrans out-out in-in TYR APEdihe_iiiai APEdist_aaai PP2 Type1 411 - 671 0 None Q432K,Q611M,D617T,Q620E Cytoplasmic tyrosine-protein kinase BMX Homo sapiens
TYR BMX BMX_HUMAN 6I99A 2.001 Inactive DFGinter‑BABtrans out-out in-in TYR APEdihe_iiiai APEdist_aaai H88 Type1 411 - 671 0 None Q432K,Q611M,D617T,Q620E Cytoplasmic tyrosine-protein kinase BMX Homo sapiens
TYR BMX BMX_HUMAN 6I99B 2.001 Inactive DFGinter‑BABtrans out-out in-in TYR APEdihe_iiiai APEdist_aaai H88 Type1 411 - 671 0 None Q432K,Q611M,D617T,Q620E Cytoplasmic tyrosine-protein kinase BMX Homo sapiens
TYR BTK BTK_HUMAN 5XYZA 2.64 Inactive DFGinter‑BABtrans out-out out-none TYR APEdihe_nniai APEdist_aaai GYL Type1 394 - 656 0 None None Tyrosine-protein kinase BTK Homo sapiens
TYR BTK BTK_HUMAN 5XYZB 2.64 Inactive DFGinter‑BABtrans out-out out-none TYR APEdihe_nniai APEdist_aaai GYL Type1 394 - 656 0 None None Tyrosine-protein kinase BTK Homo sapiens
TYR BTK BTK_HUMAN 7YC9A 1.4 Inactive DFGinter‑BABtrans out-out out-in TYR APEdihe_iiiai APEdist_aaai IS4 Type1 395 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
TYR BTK BTK_HUMAN 3OCTA 1.95 Inactive DFGinter‑BABtrans in-out out-none TYR APEdihe_nniai APEdist_aaai 1N1 Type1 394 - 656 0 None V555R Tyrosine-protein kinase BTK Homo sapiens
TYR BTK BTK_HUMAN 6NFIA 2.41 Inactive DFGinter‑None out-out none-out TYR APEdihe_niiai APEdist_aaao KLP Type1 392 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens
TYR CSK CSK_HUMAN 1BYGA 2.4 Inactive DFGinter‑BABtrans out-out none-none TYR APEdihe_nniai APEdist_aaai STU Type1 187 - 448 0 None None Tyrosine-protein kinase CSK Homo sapiens
TYR DDR1 DDR1_HUMAN 6Y23A 2.58 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 574 - 907 0 None Y569F,Y586F Epithelial discoidin domain-containing receptor 1 Homo sapiens
TYR DDR1 DDR1_HUMAN 6Y23B 2.58 Inactive DFGinter‑None in-out out-none TYR APEdihe_niiai APEdist_aaai No_ligand No_ligand 574 - 910 0 None Y569F,Y586F Epithelial discoidin domain-containing receptor 1 Homo sapiens
TYR DDR1 DDR1_HUMAN 6Y23C 2.58 Inactive DFGinter‑None in-out out-none TYR APEdihe_niiai APEdist_aaai No_ligand No_ligand 574 - 911 0 None Y569F,Y586F Epithelial discoidin domain-containing receptor 1 Homo sapiens
TYR DDR1 DDR1_HUMAN 6BRJA 2.231 Inactive DFGinter‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai VX6 Type1 605 - 913 0 None None Epithelial discoidin domain-containing receptor 1 Homo sapiens
TYR DDR1 DDR1_HUMAN 6BSDA 2.606 Inactive DFGinter‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai 1N1 Type1 604 - 912 0 None None Epithelial discoidin domain-containing receptor 1 Homo sapiens
TYR EGFR EGFR_HUMAN 8H7XB 3.404 Inactive DFGinter‑None in-in out-none TYR APEdihe_nniai APEdist_aaai No_ligand No_ligand 697 - 1018 0 None T790M,C797S Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 5XGNB 3.0 Inactive DFGinter‑None in-in out-out TYR APEdihe_oiiai APEdist_aaai No_ligand No_ligand 697 - 1019 0 None T790M,C797S Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 2JITB 3.1 Inactive DFGinter‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 697 - 1018 0 None T790M Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 2JIUB 3.05 Inactive DFGinter‑None in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 695 - 1004 0 None T790M Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 4G5PB 3.17 Inactive DFGinter‑None in-in out-out TYR APEdihe_niiai APEdist_aaao No_ligand No_ligand 697 - 1018 0 None T790M Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 3IKAB 2.9 Inactive DFGinter‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 697 - 1017 0 None T790M Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 4WD5B 3.3 Inactive DFGinter‑None in-out out-out TYR APEdihe_iiiai APEdist_aaao No_ligand No_ligand 697 - 1016 0 None T790M Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 5UWDA 3.06 Inactive DFGinter‑None out-out out-out TYR APEdihe_niiai APEdist_aaao 8OV Type1 702 - 984 0 None T790M,L858R,V948R Epidermal growth factor receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 1M7NA 2.7 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 982 - 1286 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 1M7NB 2.7 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 982 - 1286 0 None None Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 1P4OA 1.5 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 978 - 1285 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 1P4OB 1.5 Inactive DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 977 - 1290 0 None E1097A,E1099A Insulin-like growth factor 1 receptor Homo sapiens
TYR KDR VGFR2_HUMAN 1Y6AA 2.1 Inactive DFGinter‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan AAZ Type1 820 - 1167 0 None None Vascular endothelial growth factor receptor 2 Homo sapiens
TYR KDR VGFR2_HUMAN 1Y6BA 2.1 Inactive DFGinter‑None in-in none-none TYR APEdihe_nnnai APEdist_aaan AAX Type1 819 - 1168 0 None None Vascular endothelial growth factor receptor 2 Homo sapiens
TYR PTK2 FAK1_HUMAN 4EBWA 2.65 Inactive DFGinter‑None in-in none-out TYR APEdihe_niiai APEdist_aaao 0PF Type1 411 - 686 0 None None Focal adhesion kinase 1 Homo sapiens
TYR ROR2 ROR2_HUMAN 3ZZWA 2.9 Pseudo DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 466 - 750 0 None None Tyrosine-protein kinase transmembrane receptor ROR2 Homo sapiens
TYR ROR2 ROR2_HUMAN 4GT4A 2.406 Pseudo DFGinter‑None in-out out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 464 - 751 0 None None Tyrosine-protein kinase transmembrane receptor ROR2 Homo sapiens
TYR ROR2 ROR2_HUMAN 4GT4B 2.406 Pseudo DFGinter‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 464 - 752 0 None None Tyrosine-protein kinase transmembrane receptor ROR2 Homo sapiens
TYR SRC SRC_HUMAN 4MXXB 2.6 Inactive DFGinter‑BABtrans out-out none-none TYR APEdihe_nniai APEdist_aaai DB8 Type1 261 - 536 0 None A406T Proto-oncogene tyrosine-protein kinase Src Homo sapiens
TYR TEK TIE2_HUMAN 1FVRA 2.2 Inactive DFGinter‑BABtrans out-out out-out TYR APEdihe_nniai APEdist_aaao No_ligand No_ligand 813 - 1121 0 None None Angiopoietin-1 receptor Homo sapiens
TYR TEK TIE2_HUMAN 1FVRB 2.2 Inactive DFGinter‑BABtrans out-out out-out TYR APEdihe_niiai APEdist_aaao No_ligand No_ligand 813 - 1121 0 None None Angiopoietin-1 receptor Homo sapiens
CAMK AURKA AURKA_MOUSE 3DAJA 2.0 Inactive DFGinter‑None out-out none-none nonTYR APEdihe_aanii APEdist_nnnn FXG Type1 118 - 379 0 None N164G,K218R,T278D,M280L Aurora kinase A Mus musculus
TYR ABL1 ABL1_MOUSE 3DK7A 2.01 Inactive DFGinter‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai SX7 Type1 233 - 502 0 PTR393 T315I,L445P Tyrosine-protein kinase ABL1 Mus musculus
TYR ABL1 ABL1_MOUSE 3DK6A 2.02 Inactive DFGinter‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai SX7 Type1 233 - 502 0 PTR393 Y253F,L445P Tyrosine-protein kinase ABL1 Mus musculus
TYR ABL1 ABL1_MOUSE 3DK6B 2.02 Inactive DFGinter‑None in-none out-in TYR APEdihe_iiiai APEdist_aaai SX7 Type1 234 - 505 0 PTR393 Y253F,L445P Tyrosine-protein kinase ABL1 Mus musculus
TYR ABL1 ABL1_MOUSE 3DK3A 2.02 Inactive DFGinter‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai SX7 Type1 233 - 502 0 None Y393F,L445P Tyrosine-protein kinase ABL1 Mus musculus
TYR ABL1 ABL1_MOUSE 3DK3B 2.02 Inactive DFGinter‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai SX7 Type1 233 - 505 0 None Y393F,L445P Tyrosine-protein kinase ABL1 Mus musculus
TYR BTK BTK_MOUSE 8S9FA 2.6 Inactive DFGinter‑BABtrans out-out out-none TYR APEdihe_nnnai APEdist_aaan 1N1 Type1 392 - 659 0 None L390G,Y551E,Y617P Tyrosine-protein kinase BTK Mus musculus
TYR BTK BTK_MOUSE 8S9FB 2.6 Inactive DFGinter‑BABtrans out-out out-out TYR APEdihe_niiai APEdist_aaao 1N1 Type1 392 - 659 0 None L390G,Y551E,Y617P Tyrosine-protein kinase BTK Mus musculus
TYR MUSK MUSK_RAT 1LUFA 2.05 Inactive DFGinter‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 560 - 860 0 None None Muscle, skeletal receptor tyrosine protein kinase Rattus norvegicus
CAMK SNF1 SNF1_YEAST 3MN3A 2.38 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaioi APEdist_oioo No_ligand No_ligand 50 - 320 0 None None Carbon catabolite-derepressing protein kinase Saccharomyces cerevisiae
CAMK SAPK10 A0A238LNS4_9POAL 5WAXA 2.0 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 13 - 320 0 None None non-specific serine/threonine protein kinase Saccharum officinarum
CAMK SAPK10 A0A238LNS4_9POAL 5WAXB 2.0 Inactive DFGinter‑None out-none none-out nonTYR APEdihe_aaioi APEdist_nooo No_ligand No_ligand 14 - 320 0 None None non-specific serine/threonine protein kinase Saccharum officinarum
CAMK SSP2 SNF1_SCHPO 3H4JB 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo No_ligand No_ligand 27 - 351 0 None None SNF1-like protein kinase ssp2 Schizosaccharomyces pombe
AGC TB0348O8470 Q582V7_TRYB2 9Z8KB 2.05 Inactive DFGinter‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 54 - 347 0 None None Serine/threonine-protein kinase, putative Trypanosoma brucei brucei

All / DFGinter / All

Total number of chains: 27
Active chains: 0
Total number of genes: 12
Spatial label Dihedral label Number of Chains Percent Representative
DFGinter None 25 92.6% 3H4JB
DFGinter BABtrans 2 7.4% 8S9FB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CAMK SRK2E SRK2E_ARATH 3UJGA 2.6 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaiii APEdist_oooo No_ligand No_ligand 20 - 318 0 None D296A,E297A Serine/threonine-protein kinase SRK2E Arabidopsis thaliana
CAMK SRK2E SRK2E_ARATH 3UDBA 2.567 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 12 - 317 0 None S7A,S29A,S43A,C131A,C137A,C159A,S166A,T176A Serine/threonine-protein kinase SRK2E Arabidopsis thaliana
CAMK SRK2E SRK2E_ARATH 3UDBB 2.567 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 12 - 317 0 None S7A,S29A,S43A,C131A,C137A,C159A,S166A,T176A Serine/threonine-protein kinase SRK2E Arabidopsis thaliana
CAMK SRK2E SRK2E_ARATH 3UDBD 2.567 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 12 - 317 0 None S7A,S29A,S43A,C131A,C137A,C159A,S166A,T176A Serine/threonine-protein kinase SRK2E Arabidopsis thaliana
CAMK SRK2E SRK2E_ARATH 3UDBF 2.567 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 12 - 317 0 None S7A,S29A,S43A,C131A,C137A,C159A,S166A,T176A Serine/threonine-protein kinase SRK2E Arabidopsis thaliana
CAMK SRK2E SRK2E_ARATH 3UC4A 2.3 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaiii APEdist_nioo No_ligand No_ligand 12 - 318 0 None D59A,E60A Serine/threonine-protein kinase SRK2E Arabidopsis thaliana
CAMK SRK2E SRK2E_ARATH 3UC4B 2.3 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaioi APEdist_oooo No_ligand No_ligand 12 - 317 0 None D59A,E60A Serine/threonine-protein kinase SRK2E Arabidopsis thaliana
AGC GRK1 GRK1_BOVIN 3C4YB 7.509 Inactive DFGinter‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 30 - 532 0 None None Rhodopsin kinase GRK1 Bos taurus
OTHER PKNG Q8NM29_CORGL 7MXJA 1.92 Inactive DFGinter‑None out-out in-out nonTYR APEdihe_aaiii APEdist_ioii MAP Type1 62 - 358 0 None None non-specific serine/threonine protein kinase Corynebacterium glutamicum
OTHER PKNG Q8NM29_CORGL 7MXKA 1.99 Inactive DFGinter‑None out-out in-out nonTYR APEdihe_aaiii APEdist_ioii MAP Type1 63 - 360 0 None None non-specific serine/threonine protein kinase Corynebacterium glutamicum
OTHER PKNG Q8NM29_CORGL 7MXBB 2.2 Inactive DFGinter‑None out-out in-in nonTYR APEdihe_aaiii APEdist_iiii MAP Type1 54 - 727 0 None None non-specific serine/threonine protein kinase Corynebacterium glutamicum
TYR SRC SRC_CHICK 2QQ7B 2.38 Inactive DFGinter‑None none-none none-none TYR APEdihe_nnnai APEdist_aaan SR2 Type1 258 - 533 0 None T338M,S345C Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 3LOKB 2.48 Inactive DFGinter‑None none-none none-none TYR APEdihe_nnnai APEdist_aaan DJK Type1 258 - 533 0 None T338M,S345C Proto-oncogene tyrosine-protein kinase Src Gallus gallus
CAMK AURKA AURKA_MOUSE 3DAJA 2.0 Inactive DFGinter‑None out-out none-none nonTYR APEdihe_aanii APEdist_nnnn FXG Type1 118 - 379 0 None N164G,K218R,T278D,M280L Aurora kinase A Mus musculus
TYR ABL1 ABL1_MOUSE 3DK7A 2.01 Inactive DFGinter‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai SX7 Type1 233 - 502 0 PTR393 T315I,L445P Tyrosine-protein kinase ABL1 Mus musculus
TYR ABL1 ABL1_MOUSE 3DK6A 2.02 Inactive DFGinter‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai SX7 Type1 233 - 502 0 PTR393 Y253F,L445P Tyrosine-protein kinase ABL1 Mus musculus
TYR ABL1 ABL1_MOUSE 3DK6B 2.02 Inactive DFGinter‑None in-none out-in TYR APEdihe_iiiai APEdist_aaai SX7 Type1 234 - 505 0 PTR393 Y253F,L445P Tyrosine-protein kinase ABL1 Mus musculus
TYR ABL1 ABL1_MOUSE 3DK3A 2.02 Inactive DFGinter‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai SX7 Type1 233 - 502 0 None Y393F,L445P Tyrosine-protein kinase ABL1 Mus musculus
TYR ABL1 ABL1_MOUSE 3DK3B 2.02 Inactive DFGinter‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai SX7 Type1 233 - 505 0 None Y393F,L445P Tyrosine-protein kinase ABL1 Mus musculus
TYR BTK BTK_MOUSE 8S9FA 2.6 Inactive DFGinter‑BABtrans out-out out-none TYR APEdihe_nnnai APEdist_aaan 1N1 Type1 392 - 659 0 None L390G,Y551E,Y617P Tyrosine-protein kinase BTK Mus musculus
TYR BTK BTK_MOUSE 8S9FB 2.6 Inactive DFGinter‑BABtrans out-out out-out TYR APEdihe_niiai APEdist_aaao 1N1 Type1 392 - 659 0 None L390G,Y551E,Y617P Tyrosine-protein kinase BTK Mus musculus
TYR MUSK MUSK_RAT 1LUFA 2.05 Inactive DFGinter‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 560 - 860 0 None None Muscle, skeletal receptor tyrosine protein kinase Rattus norvegicus
CAMK SNF1 SNF1_YEAST 3MN3A 2.38 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aaioi APEdist_oioo No_ligand No_ligand 50 - 320 0 None None Carbon catabolite-derepressing protein kinase Saccharomyces cerevisiae
CAMK SAPK10 A0A238LNS4_9POAL 5WAXA 2.0 Inactive DFGinter‑None out-out none-out nonTYR APEdihe_aanoi APEdist_nnnn No_ligand No_ligand 13 - 320 0 None None non-specific serine/threonine protein kinase Saccharum officinarum
CAMK SAPK10 A0A238LNS4_9POAL 5WAXB 2.0 Inactive DFGinter‑None out-none none-out nonTYR APEdihe_aaioi APEdist_nooo No_ligand No_ligand 14 - 320 0 None None non-specific serine/threonine protein kinase Saccharum officinarum
CAMK SSP2 SNF1_SCHPO 3H4JB 2.8 Inactive DFGinter‑None out-out out-out nonTYR APEdihe_aaioi APEdist_iioo No_ligand No_ligand 27 - 351 0 None None SNF1-like protein kinase ssp2 Schizosaccharomyces pombe
AGC TB0348O8470 Q582V7_TRYB2 9Z8KB 2.05 Inactive DFGinter‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 54 - 347 0 None None Serine/threonine-protein kinase, putative Trypanosoma brucei brucei