Ligand: 4BM (Mirdametinib)

Total number of chains: 5
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 5 100.0% 3EQGA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
STE MAP2K1 MP2K1_HUMAN 3VVHA 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanio APEdist_nnnn ATP, 4BM ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3VVHB 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo ATP, 4BM ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3VVHC 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ATP, 4BM ATPlike, Type3 62 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3EQGA 2.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ADP, 4BM ATPlike, Type3 39 - 381 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0XB 2.47 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 4BM ATPlike, Type3 40 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1

Ligand: 4BM (Mirdametinib)

Total number of chains: 7
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 7 100.0% 3EQGA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
STE MAP2K1 MP2K1_HUMAN 3VVHA 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanio APEdist_nnnn ATP, 4BM ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3VVHB 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_oooo ATP, 4BM ATPlike, Type3 62 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3VVHC 2.0 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ATP, 4BM ATPlike, Type3 62 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 3EQGA 2.5 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaioi APEdist_oooo ADP, 4BM ATPlike, Type3 39 - 381 0 None S298N,S299K,Y300F Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7M0XB 2.47 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 4BM ATPlike, Type3 40 - 383 0 None S218A,S222A Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K1 MP2K1_RABIT 7JUUC 3.19 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 4BM ATPlike, Type3 43 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JV0C 3.63 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 4BM ATPlike, Type3 40 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus

Ligand: 4BM (Mirdametinib)

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 2 100.0% 7JV0C
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
STE MAP2K1 MP2K1_RABIT 7JUUC 3.19 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 4BM ATPlike, Type3 43 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus
STE MAP2K1 MP2K1_RABIT 7JV0C 3.63 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, 4BM ATPlike, Type3 40 - 382 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Oryctolagus cuniculus