Protein kinases in complex with 4BM (Mirdametinib)

Total number of genes: 1
Total number of chains: 5
Spatial Dihedral Chains Representative
DFGin BLBplus 5 3EQGA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 3VVHA 2.0 Inactive DFGin BLBplus out-out out-none ATP 4BM Type1 Type3
STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 3VVHB 2.0 Inactive DFGin BLBplus out-out out-out ATP 4BM Type1 Type3
STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 3VVHC 2.0 Inactive DFGin BLBplus out-out out-out ATP 4BM Type1 Type3
STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 3EQGA 2.5 Inactive DFGin BLBplus out-out out-out ADP 4BM Type1 Type3
STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 7M0XB 2.47 Inactive DFGin BLBplus out-out out-out ANP 4BM Type1 Type3

Protein kinases in complex with 4BM

Total number of genes: 1
Total number of chains: 7
Spatial Dihedral Chains Representative
DFGin BLBplus 7 3EQGA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Homo sapiens STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 3VVHA 2.0 Inactive DFGin BLBplus out-out out-none ATP 4BM Type1 Type3
Homo sapiens STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 3VVHB 2.0 Inactive DFGin BLBplus out-out out-out ATP 4BM Type1 Type3
Homo sapiens STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 3VVHC 2.0 Inactive DFGin BLBplus out-out out-out ATP 4BM Type1 Type3
Homo sapiens STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 3EQGA 2.5 Inactive DFGin BLBplus out-out out-out ADP 4BM Type1 Type3
Homo sapiens STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 7M0XB 2.47 Inactive DFGin BLBplus out-out out-out ANP 4BM Type1 Type3
Oryctolagus cuniculus STE MAP2K1 MP2K1_RABIT Dual specificity mitogen-activated protein kinase kinase 1 7JUUC 3.19 Inactive DFGin BLBplus out-out out-out ANP 4BM Type1 Type3
Oryctolagus cuniculus STE MAP2K1 MP2K1_RABIT Dual specificity mitogen-activated protein kinase kinase 1 7JV0C 3.63 Inactive DFGin BLBplus out-out out-out ANP 4BM Type1 Type3

Protein kinases in complex with 4BM

Total number of genes: 1
Total number of chains: 2
Spatial Dihedral Chains Representative
DFGin BLBplus 2 7JV0C
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Oryctolagus cuniculus STE MAP2K1 MP2K1_RABIT Dual specificity mitogen-activated protein kinase kinase 1 7JUUC 3.19 Inactive DFGin BLBplus out-out out-out ANP 4BM Type1 Type3
Oryctolagus cuniculus STE MAP2K1 MP2K1_RABIT Dual specificity mitogen-activated protein kinase kinase 1 7JV0C 3.63 Inactive DFGin BLBplus out-out out-out ANP 4BM Type1 Type3