AKT2 (RAC-beta serine/threonine-protein kinase)

Group: AGC
Uniprot: AKT2_HUMAN
Domain boundary: 152 - 409


Total number of chains: 23
Spatial Dihedral Chains Representative
DFGin BLAminus 16 AF-P31751-K1A
DFGout BBAminus 2 8Q61A
DFGout None 5 1GZKA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-P31751-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 144 - 417 None None 0
3E87A 2.3 Active DFGin BLAminus in-in in-in G95 Type1 146 - 480 S474D X309,X451 0
3E87B 2.3 Active DFGin BLAminus in-in in-in G95 Type1 146 - 480 S474D X309,X451 0
1O6KA 1.7 Active DFGin BLAminus in-in in-in ANP Type1 146 - 479 S474D X309 0
1O6LA 1.6 Active DFGin BLAminus in-in in-in ANP Type1 146 - 477 None X309 0
2JDOA 1.8 Active DFGin BLAminus in-in in-in I5S Type1 146 - 477 None X309 0
2JDRA 2.3 Active DFGin BLAminus in-in in-in L20 Type1 146 - 477 None X309 0
2UW9A 2.1 Active DFGin BLAminus in-in in-in GVP Type1 146 - 477 None X309 0
2X39A 1.93 Active DFGin BLAminus in-in in-in X39 Type1 146 - 477 None X309 0
2XH5A 2.72 Active DFGin BLAminus in-in in-in X37 Type1 146 - 479 R467Q,T468E,H469M,P471E,Q472D,S474D,S476I,S478D,I479W X309 0
3D0EA 2.0 Active DFGin BLAminus in-in in-in G93 Type1.5_Back 146 - 480 None X309,X451 0
3D0EB 2.0 Active DFGin BLAminus in-in in-in G93 Type1.5_Back 146 - 480 None X309,X451 0
3E88A 2.5 Active DFGin BLAminus in-in in-in G96 Type1.5_Back 146 - 480 S474D X309,X451 0
3E88B 2.5 Active DFGin BLAminus in-in in-in G96 Type1.5_Back 146 - 480 S474D X309,X451 0
3E8DA 2.7 Active DFGin BLAminus in-in in-in G98 Type1.5_Back 146 - 480 S474D X309,X451 0
3E8DB 2.7 Active DFGin BLAminus in-in in-in G98 Type1.5_Back 146 - 480 S474D X309,X451 0
9C1WA 2.0 Inactive DFGout BBAminus out-out none-out XOO Allosteric 3 - 440 P115A,G116A None 14
8Q61A 2.32 Inactive DFGout BBAminus out-out out-none K06 Type3 1 - 435 N2D None 6
1GZKA 2.3 Inactive DFGout None in-none none-none No_ligand No_ligand 146 - 441 None None 16
1GZOA 2.75 Inactive DFGout None in-none none-none No_ligand No_ligand 146 - 442 None None 16
1GZNA 2.5 Inactive DFGout None in-none none-none No_ligand No_ligand 146 - 442 None None 16
1MRVA 2.8 Inactive DFGout None none-none none-none No_ligand No_ligand 147 - 440 None None 19
1MRYA 2.8 Inactive DFGout None none-none none-out No_ligand No_ligand 146 - 440 None None 13

AKT2 (RAC-beta serine/threonine-protein kinase)

Group: AGC
Total number of chains: 23
Spatial Dihedral Chains Representative
DFGin BLAminus 16 AF-P31751-K1A
DFGout BBAminus 2 8Q61A
DFGout None 5 1GZKA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens AKT2_HUMAN AF-P31751-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 144 - 417 None None 0
Homo sapiens AKT2_HUMAN 3E87A 2.3 Active DFGin BLAminus in-in in-in G95 Type1 146 - 480 S474D X309,X451 0
Homo sapiens AKT2_HUMAN 3E87B 2.3 Active DFGin BLAminus in-in in-in G95 Type1 146 - 480 S474D X309,X451 0
Homo sapiens AKT2_HUMAN 1O6KA 1.7 Active DFGin BLAminus in-in in-in ANP Type1 146 - 479 S474D X309 0
Homo sapiens AKT2_HUMAN 1O6LA 1.6 Active DFGin BLAminus in-in in-in ANP Type1 146 - 477 None X309 0
Homo sapiens AKT2_HUMAN 2JDOA 1.8 Active DFGin BLAminus in-in in-in I5S Type1 146 - 477 None X309 0
Homo sapiens AKT2_HUMAN 2JDRA 2.3 Active DFGin BLAminus in-in in-in L20 Type1 146 - 477 None X309 0
Homo sapiens AKT2_HUMAN 2UW9A 2.1 Active DFGin BLAminus in-in in-in GVP Type1 146 - 477 None X309 0
Homo sapiens AKT2_HUMAN 2X39A 1.93 Active DFGin BLAminus in-in in-in X39 Type1 146 - 477 None X309 0
Homo sapiens AKT2_HUMAN 2XH5A 2.72 Active DFGin BLAminus in-in in-in X37 Type1 146 - 479 R467Q,T468E,H469M,P471E,Q472D,S474D,S476I,S478D,I479W X309 0
Homo sapiens AKT2_HUMAN 3D0EA 2.0 Active DFGin BLAminus in-in in-in G93 Type1.5_Back 146 - 480 None X309,X451 0
Homo sapiens AKT2_HUMAN 3D0EB 2.0 Active DFGin BLAminus in-in in-in G93 Type1.5_Back 146 - 480 None X309,X451 0
Homo sapiens AKT2_HUMAN 3E88A 2.5 Active DFGin BLAminus in-in in-in G96 Type1.5_Back 146 - 480 S474D X309,X451 0
Homo sapiens AKT2_HUMAN 3E88B 2.5 Active DFGin BLAminus in-in in-in G96 Type1.5_Back 146 - 480 S474D X309,X451 0
Homo sapiens AKT2_HUMAN 3E8DA 2.7 Active DFGin BLAminus in-in in-in G98 Type1.5_Back 146 - 480 S474D X309,X451 0
Homo sapiens AKT2_HUMAN 3E8DB 2.7 Active DFGin BLAminus in-in in-in G98 Type1.5_Back 146 - 480 S474D X309,X451 0
Homo sapiens AKT2_HUMAN 9C1WA 2.0 Inactive DFGout BBAminus out-out none-out XOO Allosteric 3 - 440 P115A,G116A None 14
Homo sapiens AKT2_HUMAN 8Q61A 2.32 Inactive DFGout BBAminus out-out out-none K06 Type3 1 - 435 N2D None 6
Homo sapiens AKT2_HUMAN 1GZKA 2.3 Inactive DFGout None in-none none-none No_ligand No_ligand 146 - 441 None None 16
Homo sapiens AKT2_HUMAN 1GZOA 2.75 Inactive DFGout None in-none none-none No_ligand No_ligand 146 - 442 None None 16
Homo sapiens AKT2_HUMAN 1GZNA 2.5 Inactive DFGout None in-none none-none No_ligand No_ligand 146 - 442 None None 16
Homo sapiens AKT2_HUMAN 1MRVA 2.8 Inactive DFGout None none-none none-none No_ligand No_ligand 147 - 440 None None 19
Homo sapiens AKT2_HUMAN 1MRYA 2.8 Inactive DFGout None none-none none-out No_ligand No_ligand 146 - 440 None None 13

AKT2 (RAC-beta serine/threonine-protein kinase)

No non-human structures known.