9AYA

RAF1 (RAF proto-oncogene serine/threonine-protein kinase)
MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1)
Group: STE TKL
Uniprot: MP2K1_HUMAN RAF1_HUMAN
Organism: Homo sapiens
Domain boundary: 68 - 361 349 - 608
Resolution: 2.59

Chain id Group Gene UniprotID Protein Organism Activity Spatial Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
B STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens Inactive DFGin BLBplus out-out out-out A1AHE ANP Type1 Type1 42 - 382 0
D STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens Inactive DFGin BLBplus out-out out-out A1AHE ANP Type1 Type1 39 - 382 3
A TKL RAF1 RAF1_HUMAN RAF proto-oncogene serine/threonine-protein kinase Homo sapiens None DFGin BLAminus in-none in-in No_ligand No_ligand 342 - 614 0
C TKL RAF1 RAF1_HUMAN RAF proto-oncogene serine/threonine-protein kinase Homo sapiens Inactive DFGin BLAminus in-in in-out No_ligand No_ligand 341 - 613 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain C
       345        355        365        375 
gdssdDWEIE ASEVMLSTRi gsgsFGTVYK GKWHGDVAVK 
       385        395        405        415 
IlkvvdPTPE QFQAFRNEVA VLRKTRHVNI LLFMGYMTKD 
       425        435        445        455 
NLAIVTQWCE GSSLYKHLHV QETKFQMFQL IDIARQTAQG 
       465        475        485        495 
MDYLHAKNII HRDMKSNNIF LHEGLTVKIG DFGLATVKSR 
       505        515        525        535 
WSGSQQVEQP TGSVLWMAPE VIRMQDNNPF SFQSDVYSYG 
       545        555        565        575 
IVLYELMTGE LPYSHINNRD QIIFMVGRGY ASPDLSKLYK 
       585        595        605        615 
NCPKAMKRLV ADCVKKVKEE RPLFPQILSS IELLQHSLpk


Lower-case residues are disordered in structure.
Mutations: Y340D,Y341D
Phosphorylation: None