CAMK2A (Calcium/calmodulin-dependent protein kinase type II subunit alpha)

Group: CAMK
Uniprot: KCC2A_HUMAN
Domain boundary: 13 - 271


Total number of chains: 26
Spatial Dihedral Chains Representative
DFGin BLAminus 23 AF-Q9UQM7-K1A
DFGinter None 3 3SOAA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-Q9UQM7-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 5 - 279 None None 0
7UJRA 1.95 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 7 - 274 Q223K None 0
6VZKA 2.55 Active DFGin BLAminus in-in in-in No_ligand No_ligand 7 - 274 D135N,Q223K None 0
6X5QA 2.14 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 8 - 274 D135N,Q223K None 0
7KL1A 2.4 Active DFGin BLAminus in-in in-in No_ligand No_ligand 7 - 274 D135N,Q223K None 0
7KL1B 2.4 Active DFGin BLAminus in-in in-in No_ligand No_ligand 7 - 274 D135N,Q223K None 0
7KL2A 2.56 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 7 - 274 D135N,Q223K None 0
7UIQA 3.11 Active DFGin BLAminus in-in in-in No_ligand No_ligand 7 - 274 D135N,Q223K None 0
7UIQB 3.11 Active DFGin BLAminus in-in in-in No_ligand No_ligand 8 - 273 D135N,Q223K None 0
7UISA 2.58 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 7 - 273 D135N,Q223K None 0
2VZ6A 2.3 Active DFGin BLAminus in-in in-in FEF Type1 9 - 299 None None 0
2VZ6B 2.3 Active DFGin BLAminus in-in in-in FEF Type1 9 - 300 None None 0
7UJSA 2.75 Active DFGin BLAminus in-in in-in ADP Type1 7 - 274 Q223K None 0
7KL0A 2.4 Active DFGin BLAminus in-in in-in UZD Type1 7 - 274 D135N,Q223K None 0
7KL0B 2.4 Active DFGin BLAminus in-in in-in UZD Type1 7 - 274 D135N,Q223K None 0
7UIRA 3.1 Active DFGin BLAminus in-in in-in ATP Type1 7 - 274 D135N,Q223K None 0
7UIRB 3.1 Active DFGin BLAminus in-in in-in ATP Type1 7 - 273 D135N,Q223K None 0
7UJPA 2.56 Active DFGin BLAminus in-in in-in ADP Type1 7 - 274 D135N,Q223K None 0
7UJPB 2.56 Active DFGin BLAminus in-in in-in ATP Type1 7 - 273 D135N,Q223K None 0
7UJQA 2.25 Active DFGin BLAminus in-in in-in UZD Type1 7 - 274 D135N,Q223K None 0
7UJQB 2.25 Active DFGin BLAminus in-in in-in UZD Type1 7 - 274 D135N,Q223K None 0
7UJTA 2.1 Inactive DFGin BLAminus out-out in-in ATP Type1 7 - 274 D135N,Q223K None 0
6X5GA 1.85 Active DFGin BLAminus in-in in-in BCN Type1.5_Back 7 - 274 D135N,Q223K None 0
6W4OO 4.8 Inactive DFGinter None in-none in-in No_ligand No_ligand 7 - 301 K42M None 0
6W4PH 6.6 Inactive DFGinter None in-none in-in No_ligand No_ligand 7 - 301 K42M None 0
3SOAA 3.55 Inactive DFGinter None in-none in-in DB8 Type1 7 - 474 K42M,D135N,T306V None 0

CAMK2A (Calcium/calmodulin-dependent protein kinase type II subunit alpha)

Group: CAMK
Total number of chains: 41
Spatial Dihedral Chains Representative
DFGin BLAminus 38 AF-Q9UQM7-K1A
DFGinter None 3 3SOAA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens KCC2A_HUMAN AF-Q9UQM7-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 5 - 279 None None 0
Homo sapiens KCC2A_HUMAN 7UJRA 1.95 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 7 - 274 Q223K None 0
Homo sapiens KCC2A_HUMAN 6VZKA 2.55 Active DFGin BLAminus in-in in-in No_ligand No_ligand 7 - 274 D135N,Q223K None 0
Homo sapiens KCC2A_HUMAN 6X5QA 2.14 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 8 - 274 D135N,Q223K None 0
Homo sapiens KCC2A_HUMAN 7KL1A 2.4 Active DFGin BLAminus in-in in-in No_ligand No_ligand 7 - 274 D135N,Q223K None 0
Homo sapiens KCC2A_HUMAN 7KL1B 2.4 Active DFGin BLAminus in-in in-in No_ligand No_ligand 7 - 274 D135N,Q223K None 0
Homo sapiens KCC2A_HUMAN 7KL2A 2.56 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 7 - 274 D135N,Q223K None 0
Homo sapiens KCC2A_HUMAN 7UIQA 3.11 Active DFGin BLAminus in-in in-in No_ligand No_ligand 7 - 274 D135N,Q223K None 0
Homo sapiens KCC2A_HUMAN 7UIQB 3.11 Active DFGin BLAminus in-in in-in No_ligand No_ligand 8 - 273 D135N,Q223K None 0
Homo sapiens KCC2A_HUMAN 7UISA 2.58 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 7 - 273 D135N,Q223K None 0
Homo sapiens KCC2A_HUMAN 2VZ6A 2.3 Active DFGin BLAminus in-in in-in FEF Type1 9 - 299 None None 0
Homo sapiens KCC2A_HUMAN 2VZ6B 2.3 Active DFGin BLAminus in-in in-in FEF Type1 9 - 300 None None 0
Homo sapiens KCC2A_HUMAN 7UJSA 2.75 Active DFGin BLAminus in-in in-in ADP Type1 7 - 274 Q223K None 0
Homo sapiens KCC2A_HUMAN 7KL0A 2.4 Active DFGin BLAminus in-in in-in UZD Type1 7 - 274 D135N,Q223K None 0
Homo sapiens KCC2A_HUMAN 7KL0B 2.4 Active DFGin BLAminus in-in in-in UZD Type1 7 - 274 D135N,Q223K None 0
Homo sapiens KCC2A_HUMAN 7UIRA 3.1 Active DFGin BLAminus in-in in-in ATP Type1 7 - 274 D135N,Q223K None 0
Homo sapiens KCC2A_HUMAN 7UIRB 3.1 Active DFGin BLAminus in-in in-in ATP Type1 7 - 273 D135N,Q223K None 0
Homo sapiens KCC2A_HUMAN 7UJPA 2.56 Active DFGin BLAminus in-in in-in ADP Type1 7 - 274 D135N,Q223K None 0
Homo sapiens KCC2A_HUMAN 7UJPB 2.56 Active DFGin BLAminus in-in in-in ATP Type1 7 - 273 D135N,Q223K None 0
Homo sapiens KCC2A_HUMAN 7UJQA 2.25 Active DFGin BLAminus in-in in-in UZD Type1 7 - 274 D135N,Q223K None 0
Homo sapiens KCC2A_HUMAN 7UJQB 2.25 Active DFGin BLAminus in-in in-in UZD Type1 7 - 274 D135N,Q223K None 0
Homo sapiens KCC2A_HUMAN 7UJTA 2.1 Inactive DFGin BLAminus out-out in-in ATP Type1 7 - 274 D135N,Q223K None 0
Homo sapiens KCC2A_HUMAN 6X5GA 1.85 Active DFGin BLAminus in-in in-in BCN Type1.5_Back 7 - 274 D135N,Q223K None 0
Homo sapiens KCC2A_HUMAN 6W4OO 4.8 Inactive DFGinter None in-none in-in No_ligand No_ligand 7 - 301 K42M None 0
Homo sapiens KCC2A_HUMAN 6W4PH 6.6 Inactive DFGinter None in-none in-in No_ligand No_ligand 7 - 301 K42M None 0
Homo sapiens KCC2A_HUMAN 3SOAA 3.55 Inactive DFGinter None in-none in-in DB8 Type1 7 - 474 K42M,D135N,T306V None 0
Mus musculus KCC2A_MOUSE 7B55B 1.6 Active DFGin BLAminus in-in in-in No_ligand No_ligand 5 - 312 T305A,T306A None 0
Mus musculus KCC2A_MOUSE 7B56B 1.45 Active DFGin BLAminus in-in in-in ANP Type1 5 - 307 T305A,T306A None 0
Mus musculus KCC2A_MOUSE 7B57B 1.95 Active DFGin BLAminus in-in in-in ADP Type1 5 - 307 T305A,T306A None 0
Rattus norvegicus KCC2A_RAT 5U6YA 20.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 13 - 472 None None 0
Rattus norvegicus KCC2A_RAT 5U6YB 20.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 13 - 472 None None 0
Rattus norvegicus KCC2A_RAT 5U6YC 20.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 13 - 472 None None 0
Rattus norvegicus KCC2A_RAT 5U6YD 20.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 13 - 472 None None 0
Rattus norvegicus KCC2A_RAT 5U6YE 20.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 13 - 472 None None 0
Rattus norvegicus KCC2A_RAT 5U6YF 20.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 13 - 472 None None 0
Rattus norvegicus KCC2A_RAT 5U6YG 20.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 13 - 472 None None 0
Rattus norvegicus KCC2A_RAT 5U6YH 20.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 13 - 472 None None 0
Rattus norvegicus KCC2A_RAT 5U6YI 20.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 13 - 472 None None 0
Rattus norvegicus KCC2A_RAT 5U6YJ 20.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 13 - 472 None None 0
Rattus norvegicus KCC2A_RAT 5U6YK 20.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 13 - 472 None None 0
Rattus norvegicus KCC2A_RAT 5U6YL 20.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 13 - 472 None None 0

CAMK2A (Calcium/calmodulin-dependent protein kinase type II subunit alpha)

Group: CAMK
Total number of chains: 15
Spatial Dihedral Chains Representative
DFGin BLAminus 15 7B56B
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Mus musculus KCC2A_MOUSE 7B55B 1.6 Active DFGin BLAminus in-in in-in No_ligand No_ligand 5 - 312 T305A,T306A None 0
Mus musculus KCC2A_MOUSE 7B56B 1.45 Active DFGin BLAminus in-in in-in ANP Type1 5 - 307 T305A,T306A None 0
Mus musculus KCC2A_MOUSE 7B57B 1.95 Active DFGin BLAminus in-in in-in ADP Type1 5 - 307 T305A,T306A None 0
Rattus norvegicus KCC2A_RAT 5U6YA 20.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 13 - 472 None None 0
Rattus norvegicus KCC2A_RAT 5U6YB 20.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 13 - 472 None None 0
Rattus norvegicus KCC2A_RAT 5U6YC 20.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 13 - 472 None None 0
Rattus norvegicus KCC2A_RAT 5U6YD 20.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 13 - 472 None None 0
Rattus norvegicus KCC2A_RAT 5U6YE 20.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 13 - 472 None None 0
Rattus norvegicus KCC2A_RAT 5U6YF 20.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 13 - 472 None None 0
Rattus norvegicus KCC2A_RAT 5U6YG 20.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 13 - 472 None None 0
Rattus norvegicus KCC2A_RAT 5U6YH 20.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 13 - 472 None None 0
Rattus norvegicus KCC2A_RAT 5U6YI 20.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 13 - 472 None None 0
Rattus norvegicus KCC2A_RAT 5U6YJ 20.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 13 - 472 None None 0
Rattus norvegicus KCC2A_RAT 5U6YK 20.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 13 - 472 None None 0
Rattus norvegicus KCC2A_RAT 5U6YL 20.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 13 - 472 None None 0