STE_MAP2K4 (Dual specificity mitogen-activated protein kinase kinase 4)

Total number of chains: 9
Active chains: 2
Uniprot: MP2K4_HUMAN
Kinase Domain Residues: 102 - 367
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 4 44.4% 8YP5A
None None 3 33.3% 3VUTB
DFGin BLAminus 2 22.2% AF-P45985-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-P45985-K1A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 94 - 375 0 None None Dual specificity mitogen-activated protein kinase kinase 4
AF-P45985-K3A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 94 - 375 0 None None Dual specificity mitogen-activated protein kinase kinase 4
3ALNA 2.3 Inactive DFGin‑BLBplus out-na out-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 83 - 389 0 None None Dual specificity mitogen-activated protein kinase kinase 4
3ALNB 2.3 Inactive DFGin‑BLBplus out-na out-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 84 - 390 0 None None Dual specificity mitogen-activated protein kinase kinase 4
3ALOA 2.6 Inactive DFGin‑BLBplus out-na out-out nonTYR APEdihe_aaoao APEdist_oooo ANP ATPlike 95 - 389 0 None None Dual specificity mitogen-activated protein kinase kinase 4
8YP5A 2.5 Inactive DFGin‑BLBplus out-na out-out nonTYR APEdihe_aaoai APEdist_oooo 1FM Type1 80 - 392 0 None None Dual specificity mitogen-activated protein kinase kinase 4
3ALNC 2.3 Inactive None‑None none-na none-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 100 - 390 0 None None Dual specificity mitogen-activated protein kinase kinase 4
3VUTA 3.5 Inactive None‑None none-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 142 - 388 0 None None Dual specificity mitogen-activated protein kinase kinase 4
3VUTB 3.5 Inactive None‑None out-na out-out nonTYR APEdihe_aannn APEdist_iooo No_ligand No_ligand 80 - 373 0 None None Dual specificity mitogen-activated protein kinase kinase 4

STE_MAP2K4 (Dual specificity mitogen-activated protein kinase kinase 4)

Total number of chains: 9
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 4 44.4% 8YP5A
None None 3 33.3% 3VUTB
DFGin BLAminus 2 22.2% AF-P45985-K1A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
MP2K4_HUMAN AF-P45985-K1A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 94 - 375 0 None None Dual specificity mitogen-activated protein kinase kinase 4 Homo sapiens
MP2K4_HUMAN AF-P45985-K3A -1.0 Active DFGin‑BLAminus in-na in-in nonTYR APEdihe_aaiai APEdist_iiii No_ligand No_ligand 94 - 375 0 None None Dual specificity mitogen-activated protein kinase kinase 4 Homo sapiens
MP2K4_HUMAN 3ALNA 2.3 Inactive DFGin‑BLBplus out-na out-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 83 - 389 0 None None Dual specificity mitogen-activated protein kinase kinase 4 Homo sapiens
MP2K4_HUMAN 3ALNB 2.3 Inactive DFGin‑BLBplus out-na out-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 84 - 390 0 None None Dual specificity mitogen-activated protein kinase kinase 4 Homo sapiens
MP2K4_HUMAN 3ALOA 2.6 Inactive DFGin‑BLBplus out-na out-out nonTYR APEdihe_aaoao APEdist_oooo ANP ATPlike 95 - 389 0 None None Dual specificity mitogen-activated protein kinase kinase 4 Homo sapiens
MP2K4_HUMAN 8YP5A 2.5 Inactive DFGin‑BLBplus out-na out-out nonTYR APEdihe_aaoai APEdist_oooo 1FM Type1 80 - 392 0 None None Dual specificity mitogen-activated protein kinase kinase 4 Homo sapiens
MP2K4_HUMAN 3ALNC 2.3 Inactive None‑None none-na none-none nonTYR APEdihe_aannn APEdist_nnnn ANP ATPlike 100 - 390 0 None None Dual specificity mitogen-activated protein kinase kinase 4 Homo sapiens
MP2K4_HUMAN 3VUTA 3.5 Inactive None‑None none-na out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 142 - 388 0 None None Dual specificity mitogen-activated protein kinase kinase 4 Homo sapiens
MP2K4_HUMAN 3VUTB 3.5 Inactive None‑None out-na out-out nonTYR APEdihe_aannn APEdist_iooo No_ligand No_ligand 80 - 373 0 None None Dual specificity mitogen-activated protein kinase kinase 4 Homo sapiens

STE_MAP2K4 (Dual specificity mitogen-activated protein kinase kinase 4)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism