Ligand: ANP

Total number of chains: 394
Active chains: 62
Total number of genes: 79
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 160 40.6% 8QCGA
DFGin BLBplus 140 35.5% 2SRCA
DFGin BLBtrans 31 7.9% 5X2AB
DFGin None 22 5.6% 6BXIA
DFGin ABAminus 16 4.1% 8R5EA
DFGinter None 10 2.5% 7OPOG
DFGin BLAplus 5 1.3% 2OZOA
DFGin BLBminus 5 1.3% 4LGDA
None None 3 0.8% 7F2XA
DFGout None 2 0.5% 6VPHA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC AKT1 AKT1_HUMAN 4EKKA P31749 144 477 480.0 ANP:60501 ATPlike Active DFGin 6.0476 13.1126 BLAminus -112.5, -177.27 66.46, 90.66 -111.95, 23.34 296.26, 86.16 -69.26, -23.9 in-in in 8.6509 Saltbr-in 2.9785 HRD-in -63.51, -40.13 66.5, -18.58 in-in-in SNCiii in-in ActLoopNT-in 3.0497 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.71, 172.01 APE9-dihe-na 121.09, -152.4 APE8-dihe-in -119.32, 125.09 APE8-rot-in 285.38 APE67-dihe-in -63.61, -25.53 -44.69, -42.52 APE12-dist-in 8.8136 APE11-dist-in 11.7177 APE10-dist-in 6.0702 APE9-dist-in 4.0693 S473D TPO308 TPO308 XRAY 2.8 0.22 0.28 A 341.0 319.0 0 28 28 0 [[150, 408]] 1.0 4ekk AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 4EKKB P31749 144 477 480.0 ANP:60501 ATPlike Active DFGin 6.0752 13.0461 BLAminus -112.98, 175.61 60.18, 117.01 -127.72, 18.67 304.81, 92.19 -54.85, -36.32 in-in in 8.7662 Saltbr-in 2.6652 HRD-in -65.56, -47.0 73.75, -27.2 in-in-in SNCiii in-in ActLoopNT-in 2.8192 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.2, 164.76 APE9-dihe-na 136.6, -155.35 APE8-dihe-in -114.57, 129.15 APE8-rot-in 273.31 APE67-dihe-in -63.86, -22.96 -45.74, -46.48 APE12-dist-in 8.7699 APE11-dist-in 11.6858 APE10-dist-in 6.1252 APE9-dist-in 4.2849 S473D TPO308 TPO308 XRAY 2.8 0.22 0.28 B 341.0 319.0 0 28 28 0 [[150, 408]] 1.0 4ekk AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 1O6KA P31751 146 479 481.0 ANP:1480 ATPlike Active DFGin 6.146 12.7344 BLAminus -120.8, -176.05 56.87, 82.9 -98.82, 24.49 299.36, 92.56 -61.37, -25.29 in-in in 8.7488 Saltbr-in 2.7955 HRD-in -73.34, -45.79 65.54, -9.2 in-in-in SNCiii in-in ActLoopNT-in 3.0271 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.85, 170.7 APE9-dihe-na 130.02, -155.15 APE8-dihe-in -119.36, 127.57 APE8-rot-in 291.96 APE67-dihe-in -68.55, -16.48 -36.55, -56.12 APE12-dist-in 8.1933 APE11-dist-in 11.7594 APE10-dist-in 6.1185 APE9-dist-in 3.9212 S474D TPO309 TPO309 XRAY 1.7 0.205 0.234 A 336.0 318.0 0 28 28 0 [[152, 409]] 1.0 1o6k AGC_AKT2_HUMAN AGC 1.7e-99 338.1 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 1O6LA P31751 146 477 481.0 ANP:61480 ATPlike Active DFGin 6.2578 12.9248 BLAminus -121.53, -178.18 58.41, 83.34 -98.83, 24.71 297.57, 89.85 -63.5, -19.94 in-in in 8.7937 Saltbr-in 2.7601 HRD-in -74.06, -43.29 62.88, -5.6 in-in-in SNCiii in-in ActLoopNT-in 3.0061 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.79, 169.91 APE9-dihe-na 133.49, -153.33 APE8-dihe-in -120.8, 127.55 APE8-rot-in 289.07 APE67-dihe-in -68.04, -17.15 -37.13, -54.04 APE12-dist-in 8.1734 APE11-dist-in 11.7399 APE10-dist-in 6.1223 APE9-dist-in 3.747 None TPO309 TPO309 XRAY 1.6 0.198 0.227 A 337.0 312.0 0 28 28 0 [[152, 409]] 1.0 1o6l AGC_AKT2_HUMAN AGC 1.8e-99 338.1 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC GRK5 GRK5_HUMAN 4TNDA P34947 15 543 590.0 ANP:601 ATPlike Active DFGin 5.282 13.1718 BLAminus -119.9, 173.82 59.88, 73.64 -89.53, 7.87 278.21, 112.8 -54.71, -33.69 in-in in 9.1929 Saltbr-in 3.0526 HRD-in -67.8, -56.87 74.64, -6.61 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.25, 150.21 APE9-dihe-na 143.02, -165.26 APE8-dihe-in -107.11, 142.28 APE8-rot-in 314.69 APE67-dihe-inflip 92.64, -22.22 -59.58, 132.94 APE12-dist-in 10.3015 APE11-dist-in 12.0563 APE10-dist-in 6.2302 APE9-dist-in 4.2553 None None None XRAY 1.802 0.174 0.205 A 590.0 529.0 0 27 27 0 [[186, 448]] 1.0 4tnd AGC_GRK5_HUMAN AGC 1.1e-83 286.4 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK6 GRK6_HUMAN 2ACXA P43250 14 532 576.0 ANP:577 ATPlike Active DFGin 6.2066 13.2835 BLAminus -133.82, 164.79 58.79, 76.03 -96.19, 24.41 281.42, 82.4 -59.68, -24.05 in-in in 9.3415 Saltbr-in 3.2194 HRD-in -78.26, -56.85 77.2, -1.95 in-in-in SNCiii in-in ActLoopNT-in 2.9714 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.49, 157.4 APE9-dihe-na 123.02, -168.26 APE8-dihe-in -95.03, 140.31 APE8-rot-in 303.17 APE67-dihe-in -86.56, -0.13 -45.11, -52.69 APE12-dist-in 10.4784 APE11-dist-in 11.834 APE10-dist-in 6.0832 APE9-dist-in 3.9058 C561S,C562S,C565S None None XRAY 2.6 0.204 0.243 A 576.0 495.0 0 27 27 0 [[186, 448]] 1.0 2acx AGC_GRK6_HUMAN AGC 2e-85 292.1 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 6
AGC GRK6 GRK6_HUMAN 2ACXB P43250 14 535 576.0 ANP:577 ATPlike Active DFGin 6.0903 13.1455 BLAminus -128.37, 163.87 55.35, 87.14 -100.56, 21.26 285.61, 77.77 -55.4, -30.56 in-in in 9.2313 Saltbr-in 2.4394 HRD-in -77.3, -59.12 75.78, 1.97 in-in-in SNCiii in-in ActLoopNT-in 2.9766 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.83, 161.38 APE9-dihe-na 125.99, -167.44 APE8-dihe-in -95.89, 144.8 APE8-rot-in 307.19 APE67-dihe-in -70.72, -14.39 -48.06, -55.51 APE12-dist-in 10.4768 APE11-dist-in 11.8719 APE10-dist-in 6.1674 APE9-dist-in 3.7096 C561S,C562S,C565S None None XRAY 2.6 0.204 0.243 B 576.0 492.0 5 27 27 0 [[186, 448]] 1.0 2acx AGC_GRK6_HUMAN AGC 2e-85 292.1 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 6
AGC PRKCB KPCB_HUMAN 8SE1A P05771 19 668 671.0 ANP:60706 ATPlike Active DFGin 6.0073 12.8387 BLAminus -130.5, -169.38 54.07, 70.37 -91.85, 35.76 301.77, 99.49 -89.35, 3.84 in-in in 8.3368 Saltbr-in 2.5243 HRD-in -91.65, -37.95 43.68, 28.8 in-in-in SNCiii in-in ActLoopNT-in 3.1603 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.86, 170.42 APE9-dihe-na 126.28, -151.58 APE8-dihe-in -120.81, 128.88 APE8-rot-in 299.44 APE67-dihe-in -79.06, -41.06 -50.17, -27.42 APE12-dist-in 8.8802 APE11-dist-in 12.1775 APE10-dist-in 6.66 APE9-dist-in 3.6111 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 3.32 0.202 0.256 A 674.0 607.0 0 28 28 0 [[342, 600]] 1.0 8se1 AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1.0 260.0 260.0 483 484 485 487 489 371 390 394 463 465 464 466.0 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC PRKCB KPCB_HUMAN 8SE1B P05771 19 668 671.0 ANP:60706 ATPlike Active DFGin 6.0933 12.7785 BLAminus -130.75, -169.0 53.85, 70.09 -92.15, 34.96 301.62, 99.67 -90.48, 2.45 in-in in 8.3118 Saltbr-in 2.2159 HRD-in -89.42, -35.84 47.27, 23.7 in-in-in SNCiii in-in ActLoopNT-in 3.2838 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.83, 169.92 APE9-dihe-na 126.33, -152.59 APE8-dihe-in -121.43, 128.62 APE8-rot-in 299.3 APE67-dihe-in -78.67, -41.09 -50.34, -26.64 APE12-dist-in 8.7218 APE11-dist-in 12.1824 APE10-dist-in 6.7091 APE9-dist-in 3.7667 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 3.32 0.202 0.256 B 674.0 631.0 0 28 28 0 [[342, 600]] 1.0 8se1 AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1.0 260.0 260.0 483 484 485 487 489 371 390 394 463 465 464 466.0 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC PRKCB KPCB_HUMAN 8SE2B P05771 30 671 671.0 ANP:701 ATPlike Active DFGin 5.7063 12.7369 BLAminus -122.79, -175.57 50.54, 85.22 -103.07, 33.77 300.25, 95.58 -78.87, -5.25 in-in in 8.251 Saltbr-in 2.6747 HRD-in -90.05, -48.77 75.62, -5.68 in-in-in SNCiii in-in ActLoopNT-in 3.1255 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.22, 161.28 APE9-dihe-na 125.49, -179.08 APE8-dihe-in -100.09, 129.99 APE8-rot-in 297.02 APE67-dihe-in -66.56, -21.71 -49.98, -38.79 APE12-dist-in 8.6339 APE11-dist-in 11.7118 APE10-dist-in 6.2234 APE9-dist-in 3.6063 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 2.95 0.196 0.252 B 672.0 589.0 0 28 28 0 [[342, 600]] 1.0 8se2 AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1.0 260.0 260.0 483 484 485 487 489 371 390 394 463 465 464 466.0 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC PRKCI KPCI_HUMAN 8R3YI P41743 248 585 596.0 ANP:60601 ATPlike Inactive DFGin 6.3715 12.4884 ABAminus -142.84, 3.21 -114.63, 115.49 -97.57, 12.92 307.39, 117.32 -57.63, -54.79 in-out in 9.8164 Saltbr-out 4.2411 HRD-in -70.43, -26.71 66.29, -17.13 out-in-in SNCoii in-in ActLoopNT-in 2.9084 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.32, 161.33 APE9-dihe-na 102.59, 162.36 APE8-dihe-in -70.48, 133.74 APE8-rot-in 297.7 APE67-dihe-in -64.44, -18.95 -54.13, -38.16 APE12-dist-in 8.8632 APE11-dist-in 11.2821 APE10-dist-in 5.8559 APE9-dist-in 3.4976 None TPO412,TPO564 TPO412,TPO564 EM 3.68 999.0 999.0 I 338.0 338.0 0 28 28 0 [[254, 522]] 1.0 8r3y AGC_PRKCI_HUMAN AGC 1e-95 325.7 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 5LI1A P41743 248 589 596.0 ANP:60601 ATPlike Active DFGin 5.0788 11.9615 BLAminus -129.24, 176.98 73.22, 90.17 -103.83, 11.43 308.18, 130.49 -69.42, -18.98 in-in in 8.413 Saltbr-in 2.8162 HRD-in -77.28, -52.44 73.77, 3.75 in-in-in SNCiii in-in ActLoopNT-in 2.9747 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.65, 168.01 APE9-dihe-na 127.57, -168.6 APE8-dihe-in -111.48, 126.0 APE8-rot-in 296.01 APE67-dihe-in -54.62, -31.15 -46.95, -45.66 APE12-dist-in 8.7516 APE11-dist-in 11.8219 APE10-dist-in 6.3097 APE9-dist-in 3.5172 None TPO412,SEP484,TPO564 TPO412,SEP484,TPO564 XRAY 2.0 0.154 0.217 A 354.0 332.0 10 28 28 0 [[254, 522]] 1.0 5li1 AGC_PRKCI_HUMAN AGC 1.2e-95 325.5 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKG1 KGP1_HUMAN 6BG2A Q13976 336 671 671.0 ANP:700 ATPlike Active DFGin 5.8108 14.7141 BLAminus -124.15, 169.14 66.07, 88.5 -100.57, 30.98 280.35, 66.41 -65.35, -25.12 in-in in 9.5223 Saltbr-in 2.8826 HRD-in -85.83, -52.95 73.29, 9.38 in-in-in SNCiii in-in ActLoopNT-in 2.8514 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.93, 165.57 APE9-dihe-na 117.74, 172.78 APE8-dihe-in -83.6, 129.51 APE8-rot-in 307.46 APE67-dihe-in -66.9, -19.23 -49.63, -41.3 APE12-dist-in 8.2348 APE11-dist-in 11.5121 APE10-dist-in 6.0409 APE9-dist-in 4.269 None TPO517 TPO517 XRAY 1.83 0.188 0.215 A 347.0 336.0 0 27 27 0 [[360, 619]] 1.0 6bg2 AGC_PRKG1_HUMAN AGC 2.6e-84 288.3 1.0 260.0 260.0 501 502 503 505 507 390 409 413 481 483 482 484.0 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 6BG2B Q13976 346 671 671.0 ANP:700 ATPlike Active DFGin 6.0006 13.8103 BLAminus -122.67, 175.58 65.94, 84.43 -99.77, 30.78 285.96, 70.42 -64.93, -24.07 in-in in 8.944 Saltbr-in 2.7425 HRD-in -86.95, -52.47 73.99, 7.96 in-in-in SNCiii in-in ActLoopNT-in 2.9238 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.61, 163.67 APE9-dihe-na 118.96, 172.39 APE8-dihe-in -86.94, 131.94 APE8-rot-in 306.51 APE67-dihe-in -68.79, -20.88 -48.58, -41.68 APE12-dist-in 7.8257 APE11-dist-in 11.2147 APE10-dist-in 5.7688 APE9-dist-in 4.0083 None TPO517 TPO517 XRAY 1.83 0.188 0.215 B 347.0 326.0 0 27 27 0 [[360, 619]] 1.0 6bg2 AGC_PRKG1_HUMAN AGC 2.6e-84 288.3 1.0 260.0 260.0 501 502 503 505 507 390 409 413 481 483 482 484.0 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 6BG2C Q13976 337 671 671.0 ANP:700 ATPlike Active DFGin 5.7459 14.0572 BLAminus -122.99, 175.03 65.66, 84.22 -99.61, 30.7 281.62, 66.26 -64.81, -23.57 in-in in 8.7415 Saltbr-in 2.7233 HRD-in -85.99, -53.51 74.31, 7.4 in-in-in SNCiii in-in ActLoopNT-in 2.9506 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.66, 165.85 APE9-dihe-na 118.46, 173.18 APE8-dihe-in -87.41, 130.75 APE8-rot-in 306.63 APE67-dihe-in -67.71, -19.03 -48.39, -42.55 APE12-dist-in 7.9723 APE11-dist-in 11.3847 APE10-dist-in 5.8567 APE9-dist-in 3.8612 None TPO517 TPO517 XRAY 1.83 0.188 0.215 C 347.0 335.0 0 27 27 0 [[360, 619]] 1.0 6bg2 AGC_PRKG1_HUMAN AGC 2.6e-84 288.3 1.0 260.0 260.0 501 502 503 505 507 390 409 413 481 483 482 484.0 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 6BG2D Q13976 344 671 671.0 ANP:700 ATPlike Active DFGin 5.7098 14.0124 BLAminus -124.49, 174.79 65.67, 84.87 -99.37, 30.45 283.38, 66.11 -64.13, -22.3 in-in in 8.754 Saltbr-in 2.6441 HRD-in -85.68, -52.69 74.16, 8.99 in-in-in SNCiii in-in ActLoopNT-in 2.9303 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.92, 166.42 APE9-dihe-na 119.53, 169.97 APE8-dihe-in -84.81, 130.45 APE8-rot-in 305.19 APE67-dihe-in -66.29, -19.88 -48.13, -43.31 APE12-dist-in 7.9878 APE11-dist-in 11.3267 APE10-dist-in 5.7839 APE9-dist-in 3.8102 None TPO517 TPO517 XRAY 1.83 0.188 0.215 D 347.0 328.0 0 27 27 0 [[360, 619]] 1.0 6bg2 AGC_PRKG1_HUMAN AGC 2.6e-84 288.3 1.0 260.0 260.0 501 502 503 505 507 390 409 413 481 483 482 484.0 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7LV3A Q13976 57 671 671.0 ANP:60803 ATPlike Active DFGin 5.8509 14.0363 BLAminus -116.97, 177.04 63.26, 88.72 -106.87, 28.72 283.22, 63.7 -62.95, -24.33 in-in in 8.6241 Saltbr-in 2.891 HRD-in -87.82, -54.22 74.26, 7.32 in-in-in SNCiii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.28, 149.98 APE9-dihe-na 157.95, -145.59 APE8-dihe-in -124.73, 128.61 APE8-rot-in 299.79 APE67-dihe-in -58.37, -20.06 -47.89, -51.97 APE12-dist-in 7.9724 APE11-dist-in 11.0568 APE10-dist-in 5.4693 APE9-dist-in 3.8106 None TPO517 TPO517 XRAY 2.41 0.201 0.238 A 617.0 600.0 0 27 27 0 [[360, 619]] 1.0 7lv3 AGC_PRKG1_HUMAN AGC 1.3e-83 286.3 1.0 260.0 260.0 501 502 503 505 507 390 409 413 481 483 482 484.0 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7LV3B Q13976 58 671 671.0 ANP:60803 ATPlike Active DFGin 5.6336 13.9624 BLAminus -116.52, 178.28 63.3, 90.17 -108.68, 29.08 283.48, 65.02 -62.88, -23.93 in-in in 8.8833 Saltbr-in 2.8237 HRD-in -86.48, -52.9 74.97, 7.4 in-in-in SNCiii in-in ActLoopNT-in 2.9589 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.28, 149.21 APE9-dihe-na 157.62, -145.94 APE8-dihe-in -123.75, 129.22 APE8-rot-in 300.73 APE67-dihe-in -59.05, -19.44 -46.41, -52.49 APE12-dist-in 8.1341 APE11-dist-in 11.1978 APE10-dist-in 5.6042 APE9-dist-in 3.7871 None TPO517 TPO517 XRAY 2.41 0.201 0.238 B 617.0 593.0 0 27 27 0 [[360, 619]] 1.0 7lv3 AGC_PRKG1_HUMAN AGC 1.3e-83 286.3 1.0 260.0 260.0 501 502 503 505 507 390 409 413 481 483 482 484.0 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC ROCK1 ROCK1_HUMAN 2V55A Q13464 6 404 1354.0 ANP:1480 ATPlike Active DFGin 5.8805 13.604 BLAminus -137.29, -177.31 60.22, 109.9 -132.74, 24.25 290.89, 71.12 -53.92, -52.21 in-in in 9.0764 Saltbr-in 2.7079 HRD-in -79.75, -71.28 93.49, -31.37 in-in-in SNCiii in-in ActLoopNT-in 3.2811 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.46, 139.75 APE9-dihe-na 103.51, 160.5 APE8-dihe-in -55.22, 144.8 APE8-rot-in 285.63 APE67-dihe-in -74.86, -38.79 -80.34, -13.24 APE12-dist-in 10.3243 APE11-dist-in 11.2781 APE10-dist-in 5.6467 APE9-dist-in 4.1313 None None None XRAY 3.705 0.238 0.269 A 406.0 393.0 0 29 29 0 [[76, 338]] 1.0 2v55 AGC_ROCK1_HUMAN AGC 3.3e-94 320.8 1.0 260.0 260.0 215 216 217 219 221 105 124 128 195 197 196 198.0 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 2V55C Q13464 6 404 1354.0 ANP:1480 ATPlike Active DFGin 5.8838 13.6079 BLAminus -137.56, -177.44 62.15, 108.48 -130.26, 22.71 291.3, 72.92 -54.95, -50.69 in-in in 9.1112 Saltbr-in 2.7059 HRD-in -78.29, -71.79 95.11, -31.46 in-in-in SNCiii in-in ActLoopNT-in 3.2466 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.41, 139.12 APE9-dihe-na 103.28, 159.31 APE8-dihe-in -53.48, 142.5 APE8-rot-in 287.35 APE67-dihe-in -76.24, -37.92 -78.8, -11.99 APE12-dist-in 10.2795 APE11-dist-in 11.2692 APE10-dist-in 5.6233 APE9-dist-in 4.0966 None None None XRAY 3.705 0.238 0.269 C 406.0 396.0 0 29 29 0 [[76, 338]] 1.0 2v55 AGC_ROCK1_HUMAN AGC 3.3e-94 320.8 1.0 260.0 260.0 215 216 217 219 221 105 124 128 195 197 196 198.0 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC RPS6KA1-1 KS6A1_HUMAN 8XOVA Q15418 56 340 735.0 ANP:401 ATPlike Inactive DFGin 9.5319 13.1202 BLAplus -128.25, 170.81 61.53, 44.51 -100.37, -14.37 34.15, 82.03 -83.22, -24.55 out-out out 11.1338 Saltbr-out 8.8974 HRD-in -75.5, -43.57 69.32, -59.52 out-out-out SNCooo out-out ActLoopNT-out 9.5095 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioo APE10-dihe-na -98.67, 154.58 APE9-dihe-na -175.48, 178.84 APE8-dihe-in -87.06, 119.03 APE8-rot-in 310.44 APE67-dihe-in -48.48, -27.39 -73.46, -38.49 APE12-dist-none 999.0 APE11-dist-in 10.4198 APE10-dist-out 11.5117 APE9-dist-out 7.6388 None None None XRAY 2.55 0.206 0.252 A 321.0 261.0 24 28 19 9 [[62, 321], [418, 675]] 2.0 8xov AGC_RPS6KA1-1_HUMAN AGC 1.5e-95 325.1 1.0 260.0 260.0 204 205 206 208 210 94 112 116 184 186 185 187.0 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOA P51812 45 348 740.0 ANP:401 ATPlike Inactive DFGin 5.6399 11.2827 None -75.51, -9.72 -147.12, 169.74 -135.13, 44.64 43.61, 79.33 88.97, 14.8 none-none none 999.0 Saltbr-none 999.0 HRD-in -69.31, -36.27 72.22, -63.18 none-out-out SNCnoo out-out ActLoopNT-out 10.019 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.25 APE8-rot-out 57.51 APE67-dihe-in -58.48, -32.95 -79.53, -17.69 APE12-dist-out 16.1812 APE11-dist-out 18.8341 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 A 317.0 295.0 9 28 26 2 [[68, 327], [422, 679]] 2.0 7opo AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOE P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGin 5.8283 11.217 None -75.62, -9.94 -146.57, 168.73 -137.15, 44.22 42.0, 80.75 88.39, 15.03 none-none none 999.0 Saltbr-none 999.0 HRD-in -66.39, -31.42 74.68, -62.95 none-out-out SNCnoo out-out ActLoopNT-out 10.1321 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 163.55 APE8-rot-out 177.27 APE67-dihe-in -61.67, -34.26 -80.52, -22.56 APE12-dist-out 16.151 APE11-dist-out 17.6928 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 E 317.0 293.0 10 28 26 2 [[68, 327], [422, 679]] 2.0 7opo AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOI P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGin 5.7417 11.3154 None -74.55, -8.16 -143.05, 166.95 -136.59, 41.95 46.16, 81.46 88.21, 13.52 none-none none 999.0 Saltbr-none 999.0 HRD-in -66.43, -31.99 74.45, -63.8 none-out-out SNCnoo out-out ActLoopNT-out 10.2243 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_onnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 118.34 APE8-rot-out 174.05 APE67-dihe-in -60.03, -34.02 -108.65, -14.12 APE12-dist-out 16.6879 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 I 317.0 292.0 11 28 25 3 [[68, 327], [422, 679]] 2.0 7opo AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOK P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGin 5.7434 11.0548 None -76.12, -10.81 -146.65, 168.53 -136.2, 45.6 41.69, 77.26 88.29, 15.08 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.92, -32.34 73.01, -61.24 none-out-out SNCnoo out-out ActLoopNT-out 9.9521 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 7.45 APE8-rot-out 57.97 APE67-dihe-in -59.53, -34.14 -77.79, -20.27 APE12-dist-out 17.1175 APE11-dist-out 17.3774 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 K 317.0 293.0 10 28 26 2 [[68, 327], [422, 679]] 2.0 7opo AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOC P51812 46 347 740.0 ANP:401 ATPlike Inactive DFGinter 5.815 10.9932 None -75.13, -10.43 -146.35, 169.25 -135.79, 44.23 43.29, 81.79 87.07, 14.29 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.74, -32.6 74.07, -63.87 none-out-out SNCnoo out-out ActLoopNT-out 10.1655 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -61.13, 122.89 APE9-dihe-na 75.62, 166.95 APE8-dihe-in -113.03, 115.92 APE8-rot-out 46.3 APE67-dihe-in -62.7, -36.2 -57.15, -32.55 APE12-dist-out 16.3121 APE11-dist-out 16.9338 APE10-dist-out 13.4944 APE9-dist-out 6.8696 None None None XRAY 2.75 0.209 0.232 C 317.0 295.0 7 28 28 0 [[68, 327], [422, 679]] 2.0 7opo AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOG P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGinter 6.6797 10.9627 None -75.68, -10.29 -146.32, 168.68 -137.91, 45.72 44.25, 84.07 86.95, 15.93 out-out out 19.3384 Saltbr-out 19.7531 HRD-in -66.3, -31.74 74.35, -64.56 out-out-out SNCooo out-out ActLoopNT-out 10.1118 ActLoopCT-out nonTYR APEdihe_aanni APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 105.02 APE8-rot-none 999.0 APE67-dihe-in -58.75, -33.49 -86.55, -15.46 APE12-dist-out 16.9864 APE11-dist-out 17.7665 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 G 317.0 301.0 2 28 26 2 [[68, 327], [422, 679]] 2.0 7opo AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA6-1 KS6A6_HUMAN 6G77A Q9UK32 51 349 745.0 ANP:401,ANP:402 Allosteric,ATPlike Inactive DFGin 5.9835 11.2516 None -84.57, 1.64 -160.36, 173.95 -140.73, 41.08 33.77, 88.9 86.89, 20.77 none-none none 999.0 Saltbr-none 999.0 HRD-in -75.55, -32.96 78.36, -52.1 none-out-out SNCnoo out-out ActLoopNT-out 9.9576 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 55.72, -148.34 APE9-dihe-na -103.74, -158.66 APE8-dihe-in -91.11, 113.9 APE8-rot-in 297.76 APE67-dihe-in -53.19, -20.32 -55.54, -41.19 APE12-dist-in 13.7321 APE11-dist-out 15.8714 APE10-dist-out 13.5037 APE9-dist-in 5.5319 None None None XRAY 2.499 0.188 0.233 A 307.0 291.0 8 28 28 0 [[73, 330], [426, 683]] 2.0 6g77 AGC_RPS6KA6-1_HUMAN AGC 1.1e-97 332.1 1.0 260.0 260.0 215 216 217 219 221 105 123 127 195 197 196 198.0 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G77B Q9UK32 51 349 745.0 ANP:401,ANP:402 Allosteric,ATPlike Inactive DFGin 5.612 11.3114 None -84.74, -2.79 -145.41, 176.89 -143.69, 39.64 45.89, 82.52 94.84, 15.56 none-none none 999.0 Saltbr-none 999.0 HRD-in -77.95, -30.79 74.87, -47.1 none-out-out SNCnoo out-out ActLoopNT-out 10.0706 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 55.75, -144.28 APE9-dihe-na -119.2, -153.74 APE8-dihe-in -83.74, 120.03 APE8-rot-in 297.54 APE67-dihe-in -52.98, -34.42 -57.71, -42.71 APE12-dist-in 13.9149 APE11-dist-out 16.0857 APE10-dist-out 13.633 APE9-dist-in 5.5223 None None None XRAY 2.499 0.188 0.233 B 307.0 291.0 8 28 28 0 [[73, 330], [426, 683]] 2.0 6g77 AGC_RPS6KA6-1_HUMAN AGC 1.1e-97 332.1 1.0 260.0 260.0 215 216 217 219 221 105 123 127 195 197 196 198.0 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G76B Q9UK32 51 349 745.0 ANP:401 ATPlike Inactive DFGinter 5.7966 10.9823 None -66.14, -24.76 -146.8, 171.15 -130.39, 64.5 31.65, 91.02 69.21, 34.12 none-none none 999.0 Saltbr-none 999.0 HRD-in -64.7, -28.83 65.1, -58.97 none-out-none SNCnon out-none ActLoopNT-out 9.714 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -65.75, -19.3 999.0, -17.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP232 SEP232 XRAY 3.0 0.226 0.268 B 307.0 269.0 30 28 17 11 [[73, 330], [426, 683]] 2.0 6g76 AGC_RPS6KA6-1_HUMAN AGC 1.1e-97 332.1 1.0 260.0 260.0 215 216 217 219 221 105 123 127 195 197 196 198.0 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G78A Q9UK32 51 349 745.0 ANP:401 ATPlike Inactive DFGinter 6.2685 10.6336 None -86.41, -10.47 -141.48, -170.45 -156.88, 52.15 42.27, 88.32 84.48, 16.59 none-none none 999.0 Saltbr-none 999.0 HRD-in -69.26, -28.88 63.94, -61.25 none-out-out SNCnoo out-out ActLoopNT-out 9.5896 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 82.23 APE8-dihe-out 57.69, 79.35 APE8-rot-in 324.77 APE67-dihe-in -47.93, -24.91 -65.59, -33.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 7.9125 S232E None None XRAY 2.5 0.227 0.24 A 307.0 283.0 16 28 20 8 [[73, 330], [426, 683]] 2.0 6g78 AGC_RPS6KA6-1_HUMAN AGC 1.4e-97 331.8 1.0 260.0 260.0 215 216 217 219 221 105 123 127 195 197 196 198.0 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G78B Q9UK32 51 349 745.0 ANP:401 ATPlike Inactive DFGinter 5.64 10.7376 None -79.92, -10.17 -139.49, -179.53 -146.16, 53.91 40.8, 75.5 84.23, 17.04 none-none none 999.0 Saltbr-none 999.0 HRD-in -71.51, -26.87 55.09, -79.87 none-out-out SNCnoo out-out ActLoopNT-out 9.8393 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -162.93 APE8-dihe-in -60.6, 118.59 APE8-rot-in 321.37 APE67-dihe-in -66.02, -21.47 -64.56, -33.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.8452 S232E None None XRAY 2.5 0.227 0.24 B 307.0 281.0 18 28 18 10 [[73, 330], [426, 683]] 2.0 6g78 AGC_RPS6KA6-1_HUMAN AGC 1.4e-97 331.8 1.0 260.0 260.0 215 216 217 219 221 105 123 127 195 197 196 198.0 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G76A Q9UK32 51 349 745.0 ANP:401,ANP:402 ATPlike,Allosteric Inactive DFGinter 6.2614 10.8766 None -85.39, -13.66 -143.61, 178.12 -143.21, 50.96 33.86, 88.85 75.03, 27.38 none-none none 999.0 Saltbr-none 999.0 HRD-in -70.26, -5.92 45.43, -59.01 none-out-out SNCnoo out-out ActLoopNT-out 9.8423 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 52.64, -135.92 APE9-dihe-na -103.88, -148.96 APE8-dihe-in -100.12, 127.8 APE8-rot-in 306.8 APE67-dihe-in -56.57, -28.02 -70.04, -37.97 APE12-dist-in 13.9093 APE11-dist-out 16.2474 APE10-dist-out 12.7459 APE9-dist-in 5.5959 None SEP232 SEP232 XRAY 3.0 0.226 0.268 A 307.0 291.0 8 28 28 0 [[73, 330], [426, 683]] 2.0 6g76 AGC_RPS6KA6-1_HUMAN AGC 1.1e-97 332.1 1.0 260.0 260.0 215 216 217 219 221 105 123 127 195 197 196 198.0 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC SGK1 SGK1_HUMAN 2R5TA O00141 82 378 431.0 ANP:500 ATPlike Inactive DFGinter 10.2486 5.7396 None -86.79, -16.14 -72.2, 135.26 -125.95, 20.0 58.26, 94.07 102.37, 6.12 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.44, -44.78 83.3, -51.0 none-out-out SNCnoo out-out ActLoopNT-out 9.2434 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na 54.74, 50.94 APE9-dihe-na -69.27, 152.13 APE8-dihe-in -51.76, 128.99 APE8-rot-in 305.39 APE67-dihe-out -166.98, 160.95 -53.6, 132.16 APE12-dist-out 29.8831 APE11-dist-out 30.6496 APE10-dist-out 28.0339 APE9-dist-out 16.2479 S74A,S78A,S397A,S401A None None XRAY 1.9 0.193 0.215 A 373.0 284.0 13 28 28 0 [[98, 355]] 1.0 2r5t AGC_SGK1_HUMAN AGC 4.6e-99 336.7 1.0 260.0 260.0 239 240 241 243 245 127 146 150 219 221 220 222.0 279 267 262 261 260 259 258 257 256 177 Serine/threonine-protein kinase Sgk1
AGC STK38 STK38_HUMAN 6BXIA Q15208 82 414 465.0 ANP:501 ATPlike Inactive DFGin 7.6243 15.2423 None -66.11, 165.54 -58.06, 132.91 -140.43, 160.91 66.01, 93.84 127.58, -39.07 out-out out 17.2238 Saltbr-out 15.8035 HRD-out -81.74, 95.52 -90.45, 26.47 out-out-out SNCooo out-out ActLoopNT-out 8.4633 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -99.6, -60.62 APE9-dihe-na 67.05, -156.06 APE8-dihe-in -145.17, 163.6 APE8-rot-out 65.89 APE67-dihe-in -50.28, -35.19 -91.75, 25.88 APE12-dist-out 17.3379 APE11-dist-out 14.2084 APE10-dist-out 17.7703 APE9-dist-out 12.1009 None None None XRAY 2.2 0.173 0.212 A 333.0 333.0 0 63 63 0 [[89, 382]] 1.0 6bxi AGC_STK38_HUMAN AGC 2.8e-98 334.1 1.0 260.0 260.0 229 230 231 233 235 118 137 141 209 211 210 212.0 304 292 287 286 285 284 283 282 281 167 Serine/threonine-protein kinase 38
AGC STK38 STK38_HUMAN 6BXIB Q15208 83 414 465.0 ANP:501 ATPlike Inactive DFGin 7.5828 15.1791 None -72.08, 165.13 -53.35, 130.13 -138.87, 159.98 66.77, 96.29 126.01, -39.3 out-out out 17.1655 Saltbr-out 16.0645 HRD-out -84.3, 107.68 -100.32, 27.31 out-out-out SNCooo out-out ActLoopNT-out 8.4877 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -97.07, -63.08 APE9-dihe-na 73.07, -157.98 APE8-dihe-in -144.12, 160.82 APE8-rot-out 65.98 APE67-dihe-in -53.15, -35.39 -88.29, 27.93 APE12-dist-out 17.2389 APE11-dist-out 14.1835 APE10-dist-out 17.7413 APE9-dist-out 12.0524 None None None XRAY 2.2 0.173 0.212 B 333.0 332.0 0 63 63 0 [[89, 382]] 1.0 6bxi AGC_STK38_HUMAN AGC 2.8e-98 334.1 1.0 260.0 260.0 229 230 231 233 235 118 137 141 209 211 210 212.0 304 292 287 286 285 284 283 282 281 167 Serine/threonine-protein kinase 38
CAMK AURKA AURKA_HUMAN 2DWBA O14965 126 389 403.0 ANP:502 ATPlike Inactive DFGin 5.6048 15.1145 BLAminus -136.11, 177.41 60.85, 78.38 -89.15, 29.26 286.88, 68.88 -66.25, -4.03 in-in in 9.2398 Saltbr-in 3.1689 HRD-in -70.6, -46.07 60.68, 4.1 in-in-out SNCiio in-out ActLoopNT-in 3.0356 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -134.99, -178.03 APE9-dihe-na -132.27, -116.26 APE8-dihe-in -79.37, 134.9 APE8-rot-out 179.73 APE67-dihe-in -26.2, -44.84 -85.0, -15.78 APE12-dist-in 8.0361 APE11-dist-in 12.1391 APE10-dist-out 11.1616 APE9-dist-out 10.8267 None None MSE300,MSE305,MSE373 XRAY 2.5 0.227 0.275 A 285.0 262.0 2 26 24 2 [[133, 383]] 1.0 2dwb CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPGA O14965 7 389 403.0 ANP:60401 ATPlike Active DFGin 5.3184 15.0701 BLAminus -133.54, 176.05 56.91, 81.54 -90.61, 23.9 286.39, 75.22 -62.73, -9.76 in-in in 9.8844 Saltbr-in 2.9538 HRD-in -72.51, -51.0 67.55, 11.3 in-in-in SNCiii in-in ActLoopNT-in 3.0433 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.96, 159.16 APE9-dihe-na 122.67, -152.53 APE8-dihe-in -117.94, 146.39 APE8-rot-in 309.68 APE67-dihe-in -61.83, -12.97 -52.19, -62.88 APE12-dist-in 8.5172 APE11-dist-in 11.4274 APE10-dist-in 5.7242 APE9-dist-in 3.8329 None TPO287,TPO288 TPO287,TPO288 XRAY 2.64 0.204 0.245 A 292.0 267.0 0 26 26 0 [[133, 383]] 1.0 6vpg CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPIA O14965 104 389 403.0 ANP:60601 ATPlike Inactive DFGin 5.4078 15.3189 BLAminus -130.78, 176.39 58.02, 80.51 -93.54, 25.65 284.58, 75.71 -64.44, -24.62 in-in in 9.8845 Saltbr-in 3.1969 HRD-in -68.95, -50.99 70.99, 3.21 in-in-out SNCiio in-out ActLoopNT-in 2.8207 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -142.04, 146.83 APE9-dihe-na 91.87, 167.2 APE8-dihe-in -74.18, 122.94 APE8-rot-in 319.25 APE67-dihe-in -55.59, -26.7 -100.93, -9.45 APE12-dist-in 10.0099 APE11-dist-in 12.8345 APE10-dist-out 16.1495 APE9-dist-out 20.0557 None None None XRAY 2.0 0.188 0.215 A 292.0 264.0 0 26 26 0 [[133, 383]] 1.0 6vpi CAMK_AURKA_HUMAN CAMK 6.9e-78 267.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPLA O14965 7 389 403.0 ANP:60602,R7D:60606 ATPlike,Allosteric Inactive DFGin 5.4712 15.7016 BLAminus -128.47, 179.47 64.6, 81.81 -95.02, 21.48 283.88, 78.68 -63.38, -17.61 out-out out 10.4098 Saltbr-out 4.4992 HRD-in -80.46, -54.34 74.63, 5.06 out-in-out SNCoio in-out ActLoopNT-in 2.9665 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -88.44, -6.25 APE9-dihe-na -62.06, -23.8 APE8-dihe-in -134.19, 108.37 APE8-rot-in 311.29 APE67-dihe-in -61.89, -28.27 -86.38, -9.29 APE12-dist-out 25.8944 APE11-dist-out 21.3249 APE10-dist-out 23.1598 APE9-dist-out 28.0042 None TPO288 TPO288 XRAY 1.86 0.169 0.201 A 292.0 262.0 4 26 22 4 [[133, 383]] 1.0 6vpl CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPLB O14965 7 389 403.0 ANP:60601,R7D:60605 ATPlike,Allosteric Inactive DFGin 5.5835 16.0448 BLAminus -127.84, 176.75 65.51, 80.18 -93.8, 23.88 286.09, 77.69 -67.93, -15.19 out-out out 10.6562 Saltbr-out 4.5577 HRD-in -79.97, -52.06 71.02, 4.97 out-in-out SNCoio in-out ActLoopNT-in 2.9438 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -84.27, -7.56 APE9-dihe-na -59.65, -24.89 APE8-dihe-in -135.15, 99.87 APE8-rot-in 315.26 APE67-dihe-in -58.26, -30.91 -76.18, -13.07 APE12-dist-out 25.8592 APE11-dist-out 21.4014 APE10-dist-out 23.5627 APE9-dist-out 28.2448 None TPO288 TPO288 XRAY 1.86 0.169 0.201 B 292.0 262.0 4 26 22 4 [[133, 383]] 1.0 6vpl CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2C6DA O14965 126 390 403.0 ANP:61391 ATPlike Inactive DFGin 6.2574 16.4224 None -70.12, 150.14 -40.51, 101.21 -55.1, 131.85 61.77, 102.87 98.63, -164.78 out-out out 13.1601 Saltbr-out 13.9978 HRD-out -91.98, 166.93 -128.47, 87.17 out-out-out SNCooo out-out ActLoopNT-out 17.9333 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 134.8 APE8-dihe-in -71.63, 167.98 APE8-rot-out 60.54 APE67-dihe-in -57.74, -18.95 -51.64, -36.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.0437 None None None XRAY 2.2 0.23 0.28 A 275.0 255.0 10 26 16 10 [[133, 383]] 1.0 2c6d CAMK_AURKA_HUMAN CAMK 1.5e-79 272.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPJA O14965 104 389 403.0 ANP:60401 ATPlike Inactive DFGout 12.8705 10.5737 None -110.21, 156.22 -91.65, 36.01 -66.52, 152.83 298.69, 154.8 77.13, 20.04 out-out out 11.1099 Saltbr-out 9.2857 HRD-out -138.11, 171.42 -106.7, -171.48 out-out-out SNCooo out-out ActLoopNT-out 12.6593 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -97.02, 1.42 APE9-dihe-na 78.4, 140.83 APE8-dihe-out -96.06, -166.39 APE8-rot-out 60.44 APE67-dihe-in -59.33, -27.82 -96.84, 6.17 APE12-dist-in 11.6479 APE11-dist-in 13.2558 APE10-dist-out 10.9109 APE9-dist-out 17.2151 None None None XRAY 2.1 0.192 0.215 A 292.0 263.0 3 26 23 3 [[133, 383]] 1.0 6vpj CAMK_AURKA_HUMAN CAMK 7.7e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPHA O14965 7 389 403.0 ANP:60604 ATPlike Inactive DFGout 13.6713 11.5565 None -98.71, -169.93 -135.39, 50.18 -66.9, 153.36 295.81, 141.3 65.48, 29.39 out-out out 11.3786 Saltbr-out 9.7752 HRD-out -105.53, 132.54 -112.81, 142.85 out-out-out SNCooo out-out ActLoopNT-out 14.5801 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na -129.35, -34.6 APE9-dihe-na -51.22, -37.08 APE8-dihe-out -65.53, -18.81 APE8-rot-out 65.19 APE67-dihe-in -56.69, -28.96 -65.95, -34.72 APE12-dist-out 14.7601 APE11-dist-in 9.582 APE10-dist-out 12.2573 APE9-dist-out 21.2222 None TPO287,TPO288 CAS247,TPO287,TPO288,CAS290 XRAY 2.14 0.189 0.216 A 292.0 267.0 0 26 26 0 [[133, 383]] 1.0 6vph CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK CASK CSKP_HUMAN 3MFRA O14936 5 306 926.0 ANP:500 ATPlike Pseudo DFGin 7.2881 14.824 BLAminus -130.01, -163.55 44.45, 79.28 -92.76, 26.16 280.97, 75.37 -59.27, -25.64 in-in in 9.5023 Saltbr-in 2.7988 HRD-in -78.83, -45.71 73.64, -1.18 in-in-in SNCiii in-in ActLoopNT-in 2.9977 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.41, 141.74 APE9-dihe-na 116.11, -155.43 APE8-dihe-in -114.21, 120.95 APE8-rot-in 305.84 APE67-dihe-in -66.35, -20.44 -39.68, -44.71 APE12-dist-in 11.9872 APE11-dist-in 12.4034 APE10-dist-in 6.658 APE9-dist-in 3.5931 P22A,H145E,C146N,G162D None None XRAY 2.0 0.198 0.241 A 351.0 302.0 0 28 28 0 [[12, 276]] 1.0 3mfr CAMK_CASK_HUMAN CAMK 2.4e-85 291.9 1.0 256.0 256.0 161 162 163 165 167 41 62 66 138 140 139 141.0 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3MFSA O14936 4 306 926.0 ANP:500 ATPlike Pseudo DFGin 7.1207 14.9168 BLAminus -132.54, -159.47 54.72, 71.28 -90.49, 27.88 285.64, 73.35 -63.01, -24.88 in-in in 9.8552 Saltbr-in 3.2557 HRD-in -74.69, -45.24 69.87, -1.37 in-in-in SNCiii in-in ActLoopNT-in 2.8764 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.15, 142.33 APE9-dihe-na 119.56, -149.24 APE8-dihe-in -110.99, 115.07 APE8-rot-in 303.42 APE67-dihe-in -55.02, -32.56 -38.77, -44.89 APE12-dist-in 12.0849 APE11-dist-in 12.3002 APE10-dist-in 6.637 APE9-dist-in 3.6341 P22A,H145E,C146N,G162D None None XRAY 2.1 0.221 0.268 A 351.0 303.0 0 28 28 0 [[12, 276]] 1.0 3mfs CAMK_CASK_HUMAN CAMK 2.4e-85 291.9 1.0 256.0 256.0 161 162 163 165 167 41 62 66 138 140 139 141.0 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3MFUA O14936 5 306 926.0 ANP:500 ATPlike Pseudo DFGin 7.162 14.9785 BLAminus -132.46, -169.21 51.97, 75.16 -95.02, 30.45 283.47, 72.96 -64.45, -32.11 in-in in 9.4389 Saltbr-in 3.2062 HRD-in -76.17, -45.52 71.72, -5.88 in-in-in SNCiii in-in ActLoopNT-in 2.8233 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.79, 142.93 APE9-dihe-na 117.49, -160.73 APE8-dihe-in -102.18, 121.4 APE8-rot-in 298.46 APE67-dihe-in -63.89, -19.89 -44.81, -44.73 APE12-dist-in 12.0842 APE11-dist-in 12.1946 APE10-dist-in 6.4485 APE9-dist-in 3.7371 P22A,H145E,C146N,G162D None None XRAY 2.3 0.182 0.234 A 351.0 302.0 0 28 28 0 [[12, 276]] 1.0 3mfu CAMK_CASK_HUMAN CAMK 2.4e-85 291.9 1.0 256.0 256.0 161 162 163 165 167 41 62 66 138 140 139 141.0 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 9M6GA O14936 5 312 926.0 ANP:401 ATPlike Pseudo DFGin 7.4525 15.1144 BLAminus -123.77, -152.06 75.54, 37.97 -87.68, 22.87 280.47, 84.05 -71.57, -12.61 in-in in 9.6001 Saltbr-in 2.8974 HRD-in -79.25, -45.64 76.25, -8.72 in-in-in SNCiii in-in ActLoopNT-in 2.9758 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.23, 151.66 APE9-dihe-na 106.36, -155.68 APE8-dihe-in -120.97, 120.76 APE8-rot-in 297.98 APE67-dihe-in -62.79, -20.16 -47.6, -44.68 APE12-dist-in 12.4198 APE11-dist-in 12.2151 APE10-dist-in 6.6498 APE9-dist-in 3.6453 None None None XRAY 1.7 0.167 0.187 A 325.0 308.0 0 28 28 0 [[12, 276]] 1.0 9m6g CAMK_CASK_HUMAN CAMK 4.9e-82 281.1 1.0 256.0 256.0 161 162 163 165 167 41 62 66 138 140 139 141.0 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 9M5YA O14936 3 312 926.0 ANP:401 ATPlike Pseudo DFGin 7.7139 15.5119 BLAminus -121.67, -150.51 71.79, 35.46 -86.15, 22.59 279.83, 82.24 -67.65, -16.3 in-in in 9.9588 Saltbr-in 2.8667 HRD-in -79.78, -48.63 75.37, -2.97 in-in-in SNCiii in-in ActLoopNT-in 3.0122 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.65, 147.9 APE9-dihe-na 109.7, -155.33 APE8-dihe-in -121.16, 120.88 APE8-rot-in 298.99 APE67-dihe-in -58.84, -21.41 -46.45, -46.8 APE12-dist-in 12.6873 APE11-dist-in 12.2786 APE10-dist-in 6.8567 APE9-dist-in 3.5925 None None None XRAY 1.8 0.168 0.197 A 338.0 310.0 0 28 28 0 [[12, 276]] 1.0 9m5y CAMK_CASK_HUMAN CAMK 5.6e-82 280.9 1.0 256.0 256.0 161 162 163 165 167 41 62 66 138 140 139 141.0 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CHEK1 CHK1_HUMAN 5OOPA O14757 5 271 476.0 ANP:301 ATPlike Inactive DFGin 7.0477 13.8582 BLAminus -117.87, 168.06 78.81, 84.96 -99.9, 22.77 292.72, 82.66 -69.65, -23.48 in-out in 9.5919 Saltbr-out 3.6686 HRD-in -77.29, -47.33 77.92, -0.19 out-in-in SNCoii in-in ActLoopNT-in 2.8937 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.46, 169.24 APE9-dihe-na 115.98, -146.93 APE8-dihe-in -135.24, 119.66 APE8-rot-in 302.63 APE67-dihe-in -65.46, -19.69 -46.47, -46.68 APE12-dist-in 8.8885 APE11-dist-in 11.8345 APE10-dist-in 6.194 APE9-dist-in 3.4741 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.7 0.159 0.197 A 297.0 261.0 6 30 30 0 [[9, 265]] 1.0 5oop CAMK_CHEK1_HUMAN CAMK 4.8e-69 238.4 2.0 256.0 255.0 147 148 149 151 153 38 55 59 127 129 128 130.0 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK DAPK1 DAPK1_HUMAN 1IG1A P53355 2 294 1430.0 ANP:300 ATPlike Inactive DFGin 6.604 13.9088 BLAminus -125.04, -172.1 54.91, 85.1 -99.27, 28.4 288.12, 76.24 -63.74, -23.2 in-in in 9.031 Saltbr-in 2.7496 HRD-in -78.58, -44.7 65.96, 3.14 in-in-out SNCiio in-out ActLoopNT-in 2.921 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -151.68, 130.77 APE9-dihe-na -110.11, -140.22 APE8-dihe-in -82.02, 119.3 APE8-rot-in 301.63 APE67-dihe-in -57.96, -29.17 -38.12, -46.81 APE12-dist-in 11.7974 APE11-dist-out 6.5642 APE10-dist-out 9.4133 APE9-dist-in 4.7364 None None None XRAY 1.8 0.19 0.213 A 294.0 280.0 0 27 27 0 [[13, 275]] 1.0 1ig1 CAMK_DAPK1_HUMAN CAMK 6.1e-95 323.3 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 1JKKA P53355 2 293 1430.0 ANP:300 ATPlike Inactive DFGin 6.7835 14.1245 BLAminus -129.05, -171.64 53.69, 79.96 -93.76, 28.82 285.99, 76.67 -62.99, -25.8 in-in in 9.0833 Saltbr-in 2.8517 HRD-in -75.07, -48.19 66.55, 3.19 in-in-out SNCiio in-out ActLoopNT-in 2.8179 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -147.0, 130.95 APE9-dihe-na -112.64, -140.24 APE8-dihe-in -81.46, 116.94 APE8-rot-in 307.06 APE67-dihe-in -60.31, -32.99 -34.91, -46.77 APE12-dist-in 11.7828 APE11-dist-out 6.5798 APE10-dist-out 9.4627 APE9-dist-in 4.7757 None None None XRAY 2.4 0.204 0.239 A 294.0 277.0 0 27 27 0 [[13, 275]] 1.0 1jkk CAMK_DAPK1_HUMAN CAMK 6.1e-95 323.3 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 1JKLA P53355 2 294 1430.0 ANP:300 ATPlike Inactive DFGin 6.6953 14.0571 BLAminus -124.2, -176.99 56.35, 84.0 -97.94, 28.61 287.61, 72.21 -64.45, -19.09 in-in in 9.1382 Saltbr-in 2.7337 HRD-in -79.78, -44.18 66.54, 4.23 in-in-out SNCiio in-out ActLoopNT-in 2.9055 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -149.57, 122.41 APE9-dihe-na -98.92, -146.89 APE8-dihe-in -78.98, 121.07 APE8-rot-in 305.85 APE67-dihe-in -59.69, -24.46 -37.84, -49.7 APE12-dist-in 11.6855 APE11-dist-out 6.5935 APE10-dist-out 9.371 APE9-dist-in 4.3417 None None None XRAY 1.62 0.201 0.218 A 294.0 280.0 0 27 27 0 [[13, 275]] 1.0 1jkl CAMK_DAPK1_HUMAN CAMK 6.1e-95 323.3 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3EHAA P53355 2 277 1430.0 ANP:60001 ATPlike Inactive DFGin 6.6434 13.968 BLAminus -119.49, -175.62 63.64, 76.35 -92.04, 24.1 287.15, 77.48 -66.02, -21.06 in-in in 9.1584 Saltbr-in 2.6922 HRD-in -77.77, -44.22 68.16, 6.09 in-in-out SNCiio in-out ActLoopNT-in 2.8879 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -154.08, 109.66 APE9-dihe-na -88.11, -145.31 APE8-dihe-in -81.75, 125.02 APE8-rot-in 299.42 APE67-dihe-in -58.59, -25.21 -48.84, -41.78 APE12-dist-in 11.4704 APE11-dist-out 6.0853 APE10-dist-out 9.2869 APE9-dist-in 4.2218 None None None XRAY 1.6 0.18 0.21 A 294.0 275.0 1 27 27 0 [[13, 275]] 1.0 3eha CAMK_DAPK1_HUMAN CAMK 6.1e-95 323.3 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3F5UA P53355 2 277 1430.0 ANP:60296 ATPlike Inactive DFGin 6.6797 13.9947 BLAminus -122.58, -175.66 63.1, 76.98 -89.92, 20.62 285.03, 75.31 -66.71, -20.92 in-in in 9.0543 Saltbr-in 2.6882 HRD-in -78.22, -44.99 68.31, 7.38 in-in-out SNCiio in-out ActLoopNT-in 2.898 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -161.85, 115.62 APE9-dihe-na -94.87, -137.37 APE8-dihe-in -88.11, 123.84 APE8-rot-in 295.48 APE67-dihe-in -54.81, -31.05 -45.75, -45.06 APE12-dist-in 11.55 APE11-dist-out 6.1509 APE10-dist-out 9.3577 APE9-dist-in 4.6295 None None None XRAY 2.0 0.18 0.245 A 295.0 276.0 0 27 27 0 [[13, 275]] 1.0 3f5u CAMK_DAPK1_HUMAN CAMK 6.2e-95 323.3 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3DFCB P53355 2 277 1430.0 ANP:60296 ATPlike Inactive DFGin 6.707 13.9525 BLAminus -118.29, -174.34 63.43, 75.59 -92.23, 26.78 286.33, 80.12 -73.39, -15.17 in-in in 8.9704 Saltbr-in 2.5266 HRD-in -81.02, -45.28 68.61, 4.35 in-in-out SNCiio in-out ActLoopNT-in 2.9376 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -159.6, 115.29 APE9-dihe-na -93.8, -150.98 APE8-dihe-in -71.52, 120.43 APE8-rot-in 314.5 APE67-dihe-in -56.35, -28.25 -48.91, -39.24 APE12-dist-in 10.0003 APE11-dist-out 6.5811 APE10-dist-out 9.2988 APE9-dist-in 4.2316 Q23K None None XRAY 1.9 0.168 0.23 B 295.0 276.0 0 27 27 0 [[13, 275]] 1.0 3dfc CAMK_DAPK1_HUMAN CAMK 6.8e-95 323.2 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3GU4A P53355 2 277 1430.0 ANP:60296 ATPlike Inactive DFGin 6.6865 14.2032 BLAminus -120.75, -178.24 63.74, 79.48 -95.12, 25.33 287.4, 76.71 -69.42, -15.77 in-in in 9.1537 Saltbr-in 2.7549 HRD-in -78.17, -46.9 70.13, 2.93 in-in-out SNCiio in-out ActLoopNT-in 2.8929 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -151.92, 117.7 APE9-dihe-na -90.42, -152.95 APE8-dihe-in -78.93, 125.78 APE8-rot-in 285.84 APE67-dihe-in -58.94, -26.13 -43.12, -44.76 APE12-dist-in 9.9158 APE11-dist-out 6.6991 APE10-dist-out 9.3936 APE9-dist-in 4.1456 Q23V None None XRAY 1.35 0.185 0.211 A 295.0 276.0 0 27 27 0 [[13, 275]] 1.0 3gu4 CAMK_DAPK1_HUMAN CAMK 2.1e-94 321.5 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3GU5A P53355 2 277 1430.0 ANP:60297 ATPlike Inactive DFGin 6.5951 14.0362 BLAminus -118.63, -175.92 62.35, 83.7 -99.02, 25.46 285.84, 80.17 -66.36, -22.17 in-in in 9.0755 Saltbr-in 2.7074 HRD-in -79.55, -44.61 67.36, 6.25 in-in-out SNCiio in-out ActLoopNT-in 2.938 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -153.43, 114.75 APE9-dihe-na -95.21, -137.89 APE8-dihe-in -89.62, 125.79 APE8-rot-in 297.58 APE67-dihe-in -53.19, -29.37 -44.73, -43.47 APE12-dist-in 11.313 APE11-dist-out 6.2799 APE10-dist-out 9.5719 APE9-dist-in 4.7553 Q23V None None XRAY 1.65 0.178 0.219 A 295.0 276.0 0 27 27 0 [[13, 275]] 1.0 3gu5 CAMK_DAPK1_HUMAN CAMK 2.1e-94 321.5 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK MELK MELK_HUMAN 4BL1A Q14680 2 333 651.0 ANP:1000 ATPlike Inactive DFGin 6.3379 13.9347 ABAminus -114.35, -16.21 -125.02, 95.86 -105.85, 20.97 306.05, 72.32 -48.23, -28.35 in-in in 8.5656 Saltbr-in 2.6282 HRD-in -47.49, -61.71 83.33, 5.93 in-in-out SNCiio in-out ActLoopNT-in 3.0985 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 125.09 APE8-rot-out 166.93 APE67-dihe-in -51.79, -28.37 -37.56, -42.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.184 0.26 A 347.0 312.0 20 29 15 14 [[11, 263]] 1.0 4bl1 CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK PIM1 PIM1_HUMAN 1YXTA P11309 33 306 313.0 ANP:322 ATPlike Active DFGin 6.0285 14.2451 BLAminus -131.81, 176.98 66.39, 83.69 -99.64, 19.64 287.53, 80.25 -65.72, -15.35 in-in in 8.3094 Saltbr-in 2.8936 HRD-naA -67.95, -50.18 66.45, 4.68 in-in-in SNCiii in-in ActLoopNT-in 2.8088 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.69, 12.99 APE9-dihe-na -80.03, -158.46 APE8-dihe-in -83.46, 121.7 APE8-rot-in 308.53 APE67-dihe-in -70.36, -3.81 -49.69, -52.76 APE12-dist-in 9.7291 APE11-dist-in 8.6653 APE10-dist-in 5.2788 APE9-dist-in 3.8051 None None None XRAY 2.0 0.183 0.216 A 293.0 274.0 0 26 26 0 [[38, 290]] 1.0 1yxt CAMK_PIM1_HUMAN CAMK 3.2e-65 226.0 1.0 256.0 256.0 185 186 187 189 191 67 89 93 164 166 165 167.0 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 1XR1A P11309 32 308 313.0 ANP:501 ATPlike Active DFGin 5.8877 14.2143 BLAminus -138.05, 176.98 59.78, 85.31 -96.55, 16.88 287.93, 82.19 -61.38, -7.19 in-in in 8.717 Saltbr-in 2.833 HRD-naA -59.95, -51.82 71.23, 5.72 in-in-in SNCiii in-in ActLoopNT-in 2.7525 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.05, 45.66 APE9-dihe-na -114.17, -171.15 APE8-dihe-in -64.11, 112.97 APE8-rot-in 299.41 APE67-dihe-in -49.28, -12.21 -42.84, -67.53 APE12-dist-in 9.6083 APE11-dist-in 8.6947 APE10-dist-in 5.5225 APE9-dist-in 4.0703 None None None XRAY 2.1 0.267 0.301 A 300.0 277.0 0 26 26 0 [[38, 290]] 1.0 1xr1 CAMK_PIM1_HUMAN CAMK 3.4e-65 225.8 1.0 256.0 256.0 185 186 187 189 191 67 89 93 164 166 165 167.0 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3A99A P11309 33 305 313.0 ANP:501 ATPlike Active DFGin 5.9337 14.254 BLAminus -128.38, 171.59 60.85, 87.29 -96.61, 22.08 288.57, 75.78 -65.84, -9.23 in-in in 8.7536 Saltbr-in 2.6044 HRD-naA -66.86, -47.45 66.12, 8.26 in-in-in SNCiii in-in ActLoopNT-in 2.8889 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.19, 26.41 APE9-dihe-na -87.51, -159.07 APE8-dihe-in -85.64, 119.66 APE8-rot-in 305.41 APE67-dihe-in -70.7, -5.81 -56.65, -39.81 APE12-dist-in 9.6122 APE11-dist-in 8.4607 APE10-dist-in 5.2903 APE9-dist-in 3.7779 None None None XRAY 1.6 0.187 0.206 A 320.0 273.0 0 26 26 0 [[38, 290]] 1.0 3a99 CAMK_PIM1_HUMAN CAMK 4.3e-65 225.5 1.0 256.0 256.0 185 186 187 189 191 67 89 93 164 166 165 167.0 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 2BZKB P11309 33 305 313.0 ANP:1306 ATPlike Active DFGin 6.1262 14.4434 BLAminus -123.86, 174.78 64.57, 79.13 -87.5, 17.23 286.98, 86.61 -67.5, -17.62 in-in in 8.7809 Saltbr-in 2.7266 HRD-naA -70.49, -48.81 68.36, 6.4 in-in-in SNCiii in-in ActLoopNT-in 2.8129 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.63, 10.91 APE9-dihe-na -77.79, -156.22 APE8-dihe-in -90.85, 124.06 APE8-rot-in 315.85 APE67-dihe-in -68.94, -10.63 -60.69, -42.64 APE12-dist-in 9.4641 APE11-dist-in 8.4783 APE10-dist-in 4.8507 APE9-dist-in 3.7821 R250G None None XRAY 2.45 0.191 0.225 B 313.0 268.0 5 26 26 0 [[38, 290]] 1.0 2bzk CAMK_PIM1_HUMAN CAMK 1.5e-64 223.7 1.0 256.0 256.0 185 186 187 189 191 67 89 93 164 166 165 167.0 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PLK1 PLK1_HUMAN 8X72A P53350 37 330 603.0 ANP:401 ATPlike Inactive DFGin 5.6741 14.5619 BLAminus -124.66, -175.79 56.01, 84.34 -93.5, 28.11 290.48, 83.55 -67.08, -22.62 out-in out 10.0362 Saltbr-in 3.3691 HRD-in -69.02, -52.36 73.21, 2.03 in-in-out SNCiio in-out ActLoopNT-in 2.9948 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -79.36, 95.87 APE9-dihe-na 140.51, 168.33 APE8-dihe-in -120.38, 96.0 APE8-rot-in 313.63 APE67-dihe-out -71.46, -55.88 -64.61, 149.56 APE12-dist-in 10.8497 APE11-dist-out 7.4546 APE10-dist-in 7.6527 APE9-dist-out 8.0434 None None None XRAY 2.2 0.198 0.25 A 333.0 294.0 0 28 28 0 [[53, 305]] 1.0 8x72 CAMK_PLK1_HUMAN CAMK 1.7e-78 269.4 1.0 256.0 256.0 193 194 195 197 199 82 101 105 173 175 174 176.0 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
CAMK PLK1 PLK1_HUMAN 2OU7A P53350 37 328 603.0 ANP:500 ATPlike Inactive DFGin 5.511 14.6261 BLAminus -126.46, 177.9 64.03, 83.89 -94.43, 31.27 293.9, 81.92 -69.65, -29.63 out-in out 10.0179 Saltbr-in 3.5992 HRD-in -73.43, -50.53 79.22, -6.25 in-in-out SNCiio in-out ActLoopNT-in 2.9589 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -86.17, 94.2 APE9-dihe-na 146.34, 174.25 APE8-dihe-in -131.14, 97.57 APE8-rot-in 299.54 APE67-dihe-out -68.04, -58.6 -56.03, 146.92 APE12-dist-in 10.3811 APE11-dist-out 7.1861 APE10-dist-in 7.4365 APE9-dist-out 8.2407 T210V None None XRAY 2.4 0.205 0.235 A 335.0 292.0 0 28 28 0 [[53, 305]] 1.0 2ou7 CAMK_PLK1_HUMAN CAMK 1.8e-78 269.4 1.0 256.0 256.0 193 194 195 197 199 82 101 105 173 175 174 176.0 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
CAMK PLK4 PLK4_HUMAN 3COKA O00444 2 266 970.0 ANP:60301 ATPlike Inactive DFGin 6.1437 15.3969 BLAminus -124.31, 169.68 62.14, 91.45 -100.82, 17.44 292.06, 88.73 -56.38, -36.52 in-out in 9.7683 Saltbr-out 4.5692 HRD-out -88.33, 122.35 -44.77, 114.93 out-in-none SNCoin in-none ActLoopNT-in 2.7877 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.25 0.211 0.261 A 278.0 232.0 33 28 9 19 [[12, 265]] 1.0 3cok CAMK_PLK4_HUMAN CAMK 4.8e-82 281.0 1.0 256.0 256.0 153 154 155 157 159 41 60 64 133 135 134 136.0 193 181 176 175 174 173 172 171 170 90 Serine/threonine-protein kinase PLK4
CAMK PLK4 PLK4_HUMAN 3COKB O00444 2 266 970.0 ANP:60301 ATPlike Inactive DFGin 5.9149 15.3333 BLAminus -133.97, 164.53 62.63, 97.48 -104.66, 14.21 301.0, 88.72 -54.53, -38.93 in-out in 9.8039 Saltbr-out 7.1782 HRD-out -90.24, 129.56 -55.53, 110.17 out-in-none SNCoin in-none ActLoopNT-in 2.8338 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.25 0.211 0.261 B 278.0 232.0 33 28 9 19 [[12, 265]] 1.0 3cok CAMK_PLK4_HUMAN CAMK 4.8e-82 281.0 1.0 256.0 256.0 153 154 155 157 159 41 60 64 133 135 134 136.0 193 181 176 175 174 173 172 171 170 90 Serine/threonine-protein kinase PLK4
CAMK RPS6KA5-2 KS6A5_HUMAN 3KN5A O75582 415 729 802.0 ANP:400 ATPlike None DFGin 5.4689 14.1425 BLAminus -120.9, 173.77 65.89, 86.51 -96.46, 22.04 287.59, 69.84 -51.57, -39.89 in-in in 8.8671 Saltbr-in 2.809 HRD-in -86.24, -52.51 73.21, 10.94 in-in-none SNCiin in-none ActLoopNT-in 2.9891 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.211 0.278 A 325.0 282.0 33 28 10 18 [[49, 318], [423, 687]] 2.0 3kn5 CAMK_RPS6KA5-2_HUMAN CAMK 2.1e-87 298.7 5.0 256.0 252.0 564 565 566 568 570 455 468 472 541 543 542 544.0 604 592 587 586 585 584 583 582 581 499 Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA5-2 KS6A5_HUMAN 3KN5B O75582 415 729 802.0 ANP:400 ATPlike None DFGin 5.7693 14.2111 BLAminus -127.01, 177.83 61.12, 80.37 -96.03, 24.29 287.04, 69.05 -65.01, -20.75 in-in in 8.8724 Saltbr-in 2.7381 HRD-in -80.02, -49.37 72.67, 1.66 in-in-none SNCiin in-none ActLoopNT-in 2.867 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.211 0.278 B 325.0 289.0 26 28 10 18 [[49, 318], [423, 687]] 2.0 3kn5 CAMK_RPS6KA5-2_HUMAN CAMK 2.1e-87 298.7 5.0 256.0 252.0 564 565 566 568 570 455 468 472 541 543 542 544.0 604 592 587 586 585 584 583 582 581 499 Ribosomal protein S6 kinase alpha-5
CAMK STK11 STK11_HUMAN 2WTKC Q15831 47 342 433.0 ANP:2 ATPlike Active DFGin 6.1917 13.745 BLAminus -119.65, -175.81 55.97, 66.27 -90.3, 25.87 311.18, 25.77 -80.53, -8.11 in-in in 9.443 Saltbr-in 3.361 HRD-in -68.47, -42.92 70.9, -7.9 in-in-in SNCiii in-in ActLoopNT-in 2.6483 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na 69.85, 15.07 APE9-dihe-na -72.04, -171.91 APE8-dihe-in -90.01, 115.78 APE8-rot-in 306.68 APE67-dihe-in -55.63, -13.05 -36.08, -60.58 APE12-dist-in 7.7844 APE11-dist-in 9.233 APE10-dist-in 5.3951 APE9-dist-in 3.1732 D194A None None XRAY 2.65 0.24 0.291 C 305.0 285.0 3 30 30 0 [[49, 309]] 1.0 2wtk CAMK_STK11_HUMAN CAMK 7.7e-66 228.0 1.0 256.0 256.0 193 194 195 197 199 78 98 102 173 175 174 176.0 237 223 218 217 216 215 214 213 212 130 Serine/threonine-protein kinase STK11
CAMK STK11 STK11_HUMAN 2WTKF Q15831 45 340 433.0 ANP:4 ATPlike Active DFGin 5.9384 13.841 BLAminus -119.11, -173.26 54.53, 62.76 -80.33, 19.16 295.83, 69.09 -48.31, -46.43 in-in in 9.4829 Saltbr-in 3.5682 HRD-in -68.65, -42.45 72.6, -14.65 in-in-in SNCiii in-in ActLoopNT-in 2.9216 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na 45.91, 2.58 APE9-dihe-na -73.83, 178.68 APE8-dihe-in -66.98, 134.68 APE8-rot-in 293.57 APE67-dihe-in -65.1, -33.79 -54.08, -45.39 APE12-dist-in 8.609 APE11-dist-in 9.6587 APE10-dist-in 5.7934 APE9-dist-in 3.3127 D194A None None XRAY 2.65 0.24 0.291 F 305.0 268.0 16 30 30 0 [[49, 309]] 1.0 2wtk CAMK_STK11_HUMAN CAMK 7.7e-66 228.0 1.0 256.0 256.0 193 194 195 197 199 78 98 102 173 175 174 176.0 237 223 218 217 216 215 214 213 212 130 Serine/threonine-protein kinase STK11
CK1 VRK1 VRK1_HUMAN 6AC9A Q99986 21 342 396.0 ANP:401 ATPlike Inactive DFGin 7.921 14.7058 BLAminus -114.21, 177.93 70.15, 93.84 -115.1, 19.79 299.42, 81.98 -60.26, -28.75 in-in in 7.9503 Saltbr-in 2.7794 HRD-in -85.24, -47.15 69.74, 5.52 in-in-out SNCiio in-out ActLoopNT-in 2.7991 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -132.17, 15.24 APE9-dihe-na 79.52, -153.87 APE8-dihe-in -97.68, 119.65 APE8-rot-in 299.88 APE67-dihe-in -62.87, -27.26 -44.77, -50.87 APE12-dist-in 9.478 APE11-dist-out 5.963 APE10-dist-out 10.7142 APE9-dist-in 3.8506 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.07 0.187 0.223 A 370.0 317.0 5 35 35 0 [[37, 326]] 1.0 6ac9 CK1_VRK1_HUMAN CK1 8.9e-105 355.8 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 6AC9B Q99986 21 341 396.0 ANP:401 ATPlike Inactive DFGin 7.9163 14.7395 BLAminus -115.54, 178.38 75.12, 91.43 -115.59, 17.29 297.69, 88.6 -57.57, -34.6 in-in in 8.0934 Saltbr-in 2.7697 HRD-in -83.61, -50.49 74.28, -0.88 in-in-out SNCiio in-out ActLoopNT-in 2.7931 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -114.62, 8.0 APE9-dihe-na 78.71, -152.8 APE8-dihe-in -103.98, 122.42 APE8-rot-in 297.61 APE67-dihe-in -64.96, -28.03 -44.02, -51.48 APE12-dist-in 9.9903 APE11-dist-out 5.4332 APE10-dist-out 10.7488 APE9-dist-in 3.7267 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.07 0.187 0.223 B 370.0 316.0 5 35 35 0 [[37, 326]] 1.0 6ac9 CK1_VRK1_HUMAN CK1 8.9e-105 355.8 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 6AC9C Q99986 24 341 396.0 ANP:402 ATPlike Inactive DFGin 7.9271 14.3251 BLAminus -121.92, 176.09 69.3, 88.62 -104.37, 22.99 293.32, 87.67 -64.92, -32.52 in-in in 7.6046 Saltbr-in 2.7935 HRD-in -88.58, -46.78 72.09, 4.58 in-in-out SNCiio in-out ActLoopNT-in 2.8557 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -67.72, 154.65 APE9-dihe-na 94.16, -162.22 APE8-dihe-in -91.17, 117.25 APE8-rot-in 299.96 APE67-dihe-in -65.18, -24.09 -48.81, -46.56 APE12-dist-out 14.9656 APE11-dist-in 13.64 APE10-dist-in 7.9253 APE9-dist-in 4.1526 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.07 0.187 0.223 C 370.0 307.0 11 35 35 0 [[37, 326]] 1.0 6ac9 CK1_VRK1_HUMAN CK1 8.9e-105 355.8 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 6AC9D Q99986 23 341 396.0 ANP:402 ATPlike Inactive DFGin 7.7388 14.3302 BLAminus -116.24, 179.23 65.24, 86.32 -103.3, 26.16 293.03, 86.03 -64.75, -25.98 in-in in 7.7219 Saltbr-in 2.7969 HRD-in -87.33, -42.3 69.45, 1.55 in-in-out SNCiio in-out ActLoopNT-in 2.9922 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -66.0, 154.0 APE9-dihe-na 92.71, -167.74 APE8-dihe-in -86.89, 111.15 APE8-rot-in 299.25 APE67-dihe-in -66.58, -28.49 -43.2, -46.61 APE12-dist-out 14.8296 APE11-dist-in 13.4467 APE10-dist-in 7.7373 APE9-dist-in 4.2604 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.07 0.187 0.223 D 370.0 306.0 13 35 35 0 [[37, 326]] 1.0 6ac9 CK1_VRK1_HUMAN CK1 8.9e-105 355.8 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CMGC CDK1 CDK1_HUMAN 9SKQA P06493 3 288 297.0 ANP:60301 ATPlike Inactive DFGin 7.1434 16.0323 BLAminus -125.06, -177.1 57.55, 62.82 -86.84, 50.52 271.32, 82.93 -98.1, -26.9 in-out in 9.7163 Saltbr-out 5.762 HRD-in -83.48, -58.42 64.77, 13.47 out-in-out SNCoio in-out ActLoopNT-in 2.6846 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iiii APE10-dihe-na -142.74, 165.15 APE9-dihe-na 69.23, -36.98 APE8-dihe-out 60.52, 63.14 APE8-rot-out 73.99 APE67-dihe-out 57.27, -80.66 61.32, -166.6 APE12-dist-in 12.7031 APE11-dist-in 10.0266 APE10-dist-in 7.0709 APE9-dist-in 3.7308 None TPO161 TPO161 EM 3.4 999.0 999.0 A 302.0 286.0 0 28 28 0 [[4, 287]] 1.0 9skq CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1.0 301.0 301.0 145 146 147 149 151 33 51 55 125 127 126 128.0 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
CMGC CDK12 CDK12_HUMAN 4CXAA Q9NYV4 718 1050 1490.0 ANP:2051 ATPlike Inactive DFGin 6.4362 15.0223 BLAminus -127.47, 178.63 59.83, 84.78 -103.34, 39.58 291.64, 72.71 -78.99, -14.54 in-in in 8.1775 Saltbr-in 2.5134 HRD-in -89.68, -50.66 63.81, 17.68 in-in-out SNCiio in-out ActLoopNT-in 2.7933 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -113.43, 159.2 APE9-dihe-na 63.92, 139.76 APE8-dihe-in -56.37, 145.01 APE8-rot-out 63.76 APE67-dihe-in -64.68, -22.99 -55.23, -40.79 APE12-dist-in 13.2123 APE11-dist-in 11.6623 APE10-dist-in 7.3626 APE9-dist-in 3.5055 None TPO893 TPO893 XRAY 3.15 0.224 0.279 A 340.0 330.0 3 29 28 1 [[727, 1020]] 1.0 4cxa CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK2 CDK2_HUMAN 9QCVK P24941 1 292 298.0 ANP:60301 ATPlike Inactive DFGin 6.4954 15.8072 BLAminus -144.96, -178.89 57.85, 64.57 -85.72, 49.93 282.03, 73.0 -84.65, -33.03 in-out in 9.3 Saltbr-out 4.6184 HRD-in -70.41, -54.19 69.05, 2.44 out-in-out SNCoio in-out ActLoopNT-in 2.5765 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -164.79, 153.04 APE9-dihe-na -68.87, 164.19 APE8-dihe-in -61.62, 153.89 APE8-rot-out 41.16 APE67-dihe-in -67.77, -23.98 -60.52, -33.7 APE12-dist-in 11.1549 APE11-dist-out 6.1121 APE10-dist-out 8.8972 APE9-dist-in 4.078 None None None EM 2.5 999.0 999.0 K 301.0 292.0 0 28 28 0 [[4, 286]] 1.0 9qcv CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK7 CDK7_HUMAN 8R99A P50613 10 311 346.0 ANP:401 ATPlike Inactive DFGin 6.9207 15.0738 BLAminus -136.18, 178.53 62.42, 80.05 -92.8, 32.41 285.07, 70.02 -64.17, -34.45 in-out in 9.4572 Saltbr-out 5.6061 HRD-in -70.53, -54.5 69.94, 6.7 out-in-out SNCoio in-out ActLoopNT-in 2.7107 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -115.64, 148.75 APE9-dihe-na -60.57, 161.29 APE8-dihe-in -48.68, 142.11 APE8-rot-out 161.53 APE67-dihe-in -67.83, -20.09 -55.43, -38.94 APE12-dist-in 10.4492 APE11-dist-out 5.162 APE10-dist-out 9.4484 APE9-dist-in 3.7154 W132R,S164D,T170E None None XRAY 1.81 0.178 0.22 A 371.0 283.0 19 28 28 0 [[12, 295]] 1.0 8r99 CMGC_CDK7_HUMAN CMGC 7.3e-78 269.6 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 9QCVJ P50613 10 346 346.0 ANP:60401 ATPlike Inactive DFGin 6.8121 15.5797 BLAminus -138.8, -173.47 57.69, 63.92 -85.78, 14.86 277.56, 80.3 -62.91, -29.56 in-out in 8.3041 Saltbr-out 4.7072 HRD-in -68.14, -50.51 67.46, 2.9 out-in-out SNCoio in-out ActLoopNT-in 2.8164 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -128.9, 162.73 APE9-dihe-na -74.02, 167.46 APE8-dihe-in -56.29, 150.3 APE8-rot-out 36.33 APE67-dihe-in -61.72, -30.52 -65.73, -24.93 APE12-dist-in 11.2442 APE11-dist-out 5.3402 APE10-dist-out 8.9959 APE9-dist-in 3.8077 None None None EM 2.5 999.0 999.0 J 391.0 307.0 0 28 28 0 [[12, 295]] 1.0 9qcv CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 9SKQJ P50613 9 346 346.0 ANP:60401 ATPlike Inactive DFGin 7.0888 16.0793 BLAminus -134.4, -172.6 54.33, 63.76 -84.59, 21.04 273.82, 84.09 -68.06, -13.54 in-out in 8.6851 Saltbr-out 3.6038 HRD-in -66.63, -50.41 66.76, -1.97 out-in-out SNCoio in-out ActLoopNT-in 3.0208 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -107.15, 155.19 APE9-dihe-na -64.85, 155.06 APE8-dihe-in -50.04, 149.57 APE8-rot-out 168.49 APE67-dihe-in -67.74, -34.69 -63.59, -17.75 APE12-dist-in 10.5875 APE11-dist-out 5.6701 APE10-dist-out 9.403 APE9-dist-in 3.9875 None None None EM 3.4 999.0 999.0 J 391.0 306.0 0 28 28 0 [[12, 295]] 1.0 9skq CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BA P50613 1 311 346.0 ANP:401 ATPlike Inactive DFGin 6.6665 15.0398 None -136.41, -179.13 75.36, -66.57 59.32, 16.33 291.11, 69.78 55.95, 32.69 out-out out 13.486 Saltbr-out 13.7543 HRD-in -65.3, -54.78 73.94, 0.68 out-out-out SNCooo out-out ActLoopNT-out 12.5504 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -74.63, 115.42 APE9-dihe-na -115.54, -2.31 APE8-dihe-out -56.05, -31.84 APE8-rot-out 157.42 APE67-dihe-in -63.34, -23.16 -66.49, -24.29 APE12-dist-out 18.0017 APE11-dist-out 20.1866 APE10-dist-out 16.0858 APE9-dist-out 11.4652 S164D,T170E None None XRAY 2.21 0.195 0.243 A 352.0 301.0 10 28 28 0 [[12, 295]] 1.0 8r9b CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BB P50613 3 310 346.0 ANP:402 ATPlike Inactive DFGin 6.5631 15.0836 None -126.22, 177.01 84.52, -73.28 65.77, 22.93 292.14, 76.04 47.33, 39.02 out-out out 13.6069 Saltbr-out 11.882 HRD-in -71.08, -53.54 74.78, -6.63 out-out-out SNCooo out-out ActLoopNT-out 12.9359 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -81.04, 115.32 APE9-dihe-na -115.04, 1.93 APE8-dihe-out -60.49, -32.76 APE8-rot-out 168.86 APE67-dihe-in -59.67, -24.77 -68.61, -28.01 APE12-dist-out 17.7792 APE11-dist-out 20.1865 APE10-dist-out 16.1566 APE9-dist-out 11.4157 S164D,T170E None None XRAY 2.21 0.195 0.243 B 352.0 298.0 10 28 28 0 [[12, 295]] 1.0 8r9b CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BC P50613 8 311 346.0 ANP:402 ATPlike Inactive DFGin 6.4512 15.3403 None -116.21, 176.78 77.39, -97.04 64.16, 26.01 311.61, 20.83 46.47, 58.36 out-out out 13.1044 Saltbr-out 12.1328 HRD-in -78.41, -55.45 77.67, -2.52 out-out-out SNCooo out-out ActLoopNT-out 12.9218 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 132.76 APE9-dihe-na -87.2, -35.35 APE8-dihe-out -49.87, -35.32 APE8-rot-in 271.7 APE67-dihe-in -63.34, -21.13 -58.67, -34.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.9279 APE9-dist-out 10.9338 S164D,T170E None None XRAY 2.21 0.195 0.243 C 352.0 276.0 28 28 16 12 [[12, 295]] 1.0 8r9b CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BD P50613 9 311 346.0 ANP:402 ATPlike Inactive DFGin 5.1856 15.5294 None -119.23, -173.72 58.44, -119.7 56.58, 114.74 106.06, 59.9 70.5, -151.21 out-out out 13.0617 Saltbr-out 12.3535 HRD-in -80.52, -56.05 80.67, -8.56 out-out-out SNCooo out-out ActLoopNT-out 13.0554 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -29.49 APE9-dihe-na -113.47, -32.42 APE8-dihe-out -62.11, -27.52 APE8-rot-out 75.68 APE67-dihe-in -62.12, -24.79 -50.05, -35.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.1604 APE9-dist-out 11.1556 S164D,T170E None None XRAY 2.21 0.195 0.243 D 352.0 277.0 26 28 18 10 [[12, 295]] 1.0 8r9b CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK9 CDK9_HUMAN 3MIAA P50750 8 340 372.0 ANP:352 ATPlike Active DFGin 6.803 15.0773 BLAminus -137.71, 176.33 64.58, 74.97 -96.55, 26.44 284.7, 90.38 -67.18, -14.54 in-in in 9.3135 Saltbr-in 2.6891 HRD-in -70.81, -51.43 63.16, 28.9 in-in-in SNCiii in-in ActLoopNT-in 2.9572 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.04, 160.49 APE9-dihe-na 82.03, 127.94 APE8-dihe-in -49.75, 143.51 APE8-rot-in 280.63 APE67-dihe-in -52.26, -14.47 -51.96, -57.94 APE12-dist-in 13.2577 APE11-dist-in 11.5238 APE10-dist-in 6.949 APE9-dist-in 3.5228 None TPO186 TPO186 XRAY 3.0 0.219 0.287 A 351.0 325.0 8 32 32 0 [[19, 315]] 1.0 3mia CMGC_CDK9_HUMAN CMGC 5.1e-80 274.8 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CMGC CSNK2A1 CSK21_HUMAN 3JUHA P68400 2 335 391.0 ANP:339 ATPlike Active DFGin 7.4007 16.2423 BLAminus -115.69, -178.29 60.62, 71.57 -93.06, 11.37 295.1, 82.09 -62.22, -22.13 in-in in 9.7211 Saltbr-in 2.7457 HRD-in -70.06, -49.94 64.15, 21.46 in-in-in SNCiii in-in ActLoopNT-in 2.8624 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.98, 153.86 APE9-dihe-na 70.33, -177.46 APE8-dihe-in -104.19, 142.14 APE8-rot-in 291.28 APE67-dihe-in -67.33, -12.83 -40.87, -55.27 APE12-dist-in 12.3163 APE11-dist-in 9.5782 APE10-dist-in 6.0441 APE9-dist-in 3.0857 V66A,M163L None None XRAY 1.66 0.158 0.218 A 335.0 334.0 0 27 27 0 [[39, 324]] 1.0 3juh CMGC_CSNK2A1_HUMAN CMGC 1.1e-70 244.1 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 3JUHB P68400 2 335 391.0 ANP:339 ATPlike Active DFGin 7.4915 16.3556 BLAminus -124.69, -176.29 51.46, 71.26 -80.35, 23.48 299.01, 83.37 -80.68, -22.43 in-in in 9.8518 Saltbr-in 2.6994 HRD-in -76.38, -50.5 78.84, -1.13 in-in-in SNCiii in-in ActLoopNT-in 2.8067 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.59, 175.23 APE9-dihe-na 56.07, 138.8 APE8-dihe-in -58.03, 149.04 APE8-rot-in 282.66 APE67-dihe-in -69.98, -19.52 -43.94, -46.02 APE12-dist-in 12.7139 APE11-dist-in 9.5413 APE10-dist-in 5.8839 APE9-dist-in 3.4107 V66A,M163L None None XRAY 1.66 0.158 0.218 B 335.0 334.0 0 27 27 0 [[39, 324]] 1.0 3juh CMGC_CSNK2A1_HUMAN CMGC 1.1e-70 244.1 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 3NSZA P68400 2 328 391.0 ANP:1000 ATPlike Active DFGin 7.2905 16.6392 BLAminus -116.89, -174.28 57.53, 72.95 -91.24, 19.04 295.43, 81.74 -67.97, -19.44 in-in in 9.5596 Saltbr-in 2.7206 HRD-in -71.38, -46.87 68.1, 12.99 in-in-in SNCiii in-in ActLoopNT-in 2.8692 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.59, 174.99 APE9-dihe-na 61.7, -173.37 APE8-dihe-in -118.84, 140.8 APE8-rot-in 296.4 APE67-dihe-in -69.07, -13.11 -30.5, -60.15 APE12-dist-in 12.6047 APE11-dist-in 10.3158 APE10-dist-in 6.145 APE9-dist-in 2.961 None None None XRAY 1.3 0.169 0.187 A 330.0 327.0 0 27 27 0 [[39, 324]] 1.0 3nsz CMGC_CSNK2A1_HUMAN CMGC 1.3e-69 240.7 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 1PJKA P68400 2 332 391.0 ANP:340 ATPlike Active DFGin 7.4402 16.2383 BLAminus -115.92, -179.78 53.21, 80.99 -96.44, 28.53 295.64, 78.1 -72.28, -30.66 in-in in 8.9302 Saltbr-in 2.8101 HRD-in -80.54, -40.11 57.34, 9.1 in-in-in SNCiii in-in ActLoopNT-in 3.0195 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.58, 173.24 APE9-dihe-na 63.2, 174.94 APE8-dihe-in -93.15, 157.9 APE8-rot-in 277.8 APE67-dihe-in -66.77, -23.27 -54.74, -47.48 APE12-dist-in 13.0256 APE11-dist-in 10.6695 APE10-dist-in 6.3684 APE9-dist-in 3.1734 None None None XRAY 2.5 0.188 0.257 A 334.0 331.0 0 27 27 0 [[39, 324]] 1.0 1pjk CMGC_CSNK2A1_HUMAN CMGC 1.3e-69 240.6 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 2PVRA P68400 2 329 391.0 ANP:6004 ATPlike Active DFGin 7.4922 16.4969 BLAminus -121.67, -179.6 56.35, 70.32 -89.0, 17.49 296.64, 81.69 -72.81, -15.87 in-in in 9.2839 Saltbr-in 2.7005 HRD-in -75.03, -46.77 70.22, 6.37 in-in-in SNCiii in-in ActLoopNT-in 2.8603 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.8, 175.01 APE9-dihe-na 60.61, 163.14 APE8-dihe-in -93.89, 147.69 APE8-rot-in 305.18 APE67-dihe-in -67.68, -15.16 -34.32, -58.13 APE12-dist-in 12.7281 APE11-dist-in 10.3458 APE10-dist-in 6.1308 APE9-dist-in 3.1892 None None None XRAY 1.605 0.187 0.241 A 334.0 328.0 0 27 27 0 [[39, 324]] 1.0 2pvr CMGC_CSNK2A1_HUMAN CMGC 1.3e-69 240.6 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 3WOWA P68400 2 335 391.0 ANP:403 ATPlike Inactive DFGin 7.3618 16.2106 BLAminus -119.7, -164.32 31.16, 87.67 -91.29, 15.78 292.48, 84.38 -76.59, -15.17 in-in in 9.0133 Saltbr-in 2.8966 HRD-in -75.03, -42.77 66.59, 8.6 in-in-out SNCiio in-out ActLoopNT-in 2.827 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -147.66, 173.4 APE9-dihe-na 59.33, 149.57 APE8-dihe-in -60.19, 149.81 APE8-rot-out 155.74 APE67-dihe-in -68.18, -10.89 -45.04, -52.54 APE12-dist-in 12.4625 APE11-dist-in 9.8934 APE10-dist-in 6.0041 APE9-dist-in 3.2376 None None None XRAY 2.5 0.187 0.24 A 340.0 334.0 0 27 27 0 [[39, 324]] 1.0 3wow CMGC_CSNK2A1_HUMAN CMGC 1.4e-69 240.5 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 1JWHA P68400 2 337 391.0 ANP:340 ATPlike Inactive DFGin 7.2516 16.2349 BLAminus -136.81, -165.56 40.66, 74.27 -89.27, 13.16 294.34, 91.77 -66.65, -32.67 in-in in 9.5638 Saltbr-in 2.5057 HRD-in -80.54, -35.51 50.69, 18.56 in-in-out SNCiio in-out ActLoopNT-in 2.9318 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -124.17, 169.91 APE9-dihe-na 68.04, 157.3 APE8-dihe-in -72.41, 153.53 APE8-rot-out 204.94 APE67-dihe-in -51.97, -16.72 -49.32, -64.87 APE12-dist-in 12.7307 APE11-dist-in 10.8563 APE10-dist-in 6.2863 APE9-dist-in 3.369 None None None XRAY 3.1 0.267 0.338 A 337.0 336.0 0 27 27 0 [[39, 324]] 1.0 1jwh CMGC_CSNK2A1_HUMAN CMGC 1.4e-69 240.6 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 3U87A P68400 2 331 391.0 ANP:60401 ATPlike Inactive DFGin 7.5451 16.2307 BLAminus -123.37, -169.57 51.0, 85.39 -106.65, 25.22 299.48, 83.64 -72.72, -19.34 in-in in 9.2674 Saltbr-in 2.765 HRD-in -71.91, -49.46 70.99, 8.66 in-in-out SNCiio in-out ActLoopNT-in 2.8507 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.96, 169.28 APE9-dihe-na 66.95, 166.44 APE8-dihe-in -75.94, 153.25 APE8-rot-out 174.74 APE67-dihe-in -70.96, -11.07 -53.15, -46.69 APE12-dist-in 12.8429 APE11-dist-in 11.0354 APE10-dist-in 6.142 APE9-dist-in 3.5391 None None None XRAY 2.9 0.187 0.218 A 349.0 324.0 0 27 27 0 [[39, 324]] 1.0 3u87 CMGC_CSNK2A1_HUMAN CMGC 1.5e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 3U87B P68400 2 331 391.0 ANP:60401 ATPlike Active DFGin 7.4708 16.335 BLAminus -123.33, -169.35 50.94, 85.5 -106.65, 24.88 299.58, 83.47 -72.97, -19.72 in-in in 9.5055 Saltbr-in 2.8482 HRD-in -72.0, -49.6 70.96, 8.41 in-in-in SNCiii in-in ActLoopNT-in 2.7801 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.34, 168.89 APE9-dihe-na 66.61, 166.24 APE8-dihe-in -76.34, 153.62 APE8-rot-in 296.27 APE67-dihe-in -70.99, -10.83 -52.99, -46.79 APE12-dist-in 12.8215 APE11-dist-in 10.8013 APE10-dist-in 6.1498 APE9-dist-in 3.5766 None None None XRAY 2.9 0.187 0.218 B 349.0 324.0 0 27 27 0 [[39, 324]] 1.0 3u87 CMGC_CSNK2A1_HUMAN CMGC 1.5e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A2 CSK22_HUMAN 8QCGA P19784 7 330 350.0 ANP:401 ATPlike Inactive DFGin 7.2922 16.4059 BLAminus -116.12, -179.5 60.93, 75.12 -92.44, 17.38 295.14, 82.0 -69.37, -19.53 in-out in 9.9974 Saltbr-out 4.5956 HRD-in -74.12, -49.68 72.07, 8.96 out-in-in SNCoii in-in ActLoopNT-in 2.8896 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.46, 172.69 APE9-dihe-na 61.42, 170.02 APE8-dihe-in -97.67, 147.66 APE8-rot-in 300.74 APE67-dihe-in -69.16, -14.55 -36.76, -56.59 APE12-dist-in 12.627 APE11-dist-in 10.1807 APE10-dist-in 6.1313 APE9-dist-in 3.1203 C336S None None XRAY 1.04 0.151 0.17 A 364.0 324.0 0 27 27 0 [[40, 325]] 1.0 8qcg CMGC_CSNK2A2_HUMAN CMGC 1e-69 241.0 1.0 301.0 301.0 175 176 177 179 181 69 82 86 154 156 155 157.0 215 202 197 196 195 194 193 192 191 115 Casein kinase II subunit alpha'
CMGC CSNK2A2 CSK22_HUMAN 8QCGB P19784 7 333 350.0 ANP:401 ATPlike Active DFGin 7.3143 16.2087 BLAminus -113.91, -178.96 61.11, 75.42 -92.86, 17.98 298.38, 79.8 -69.62, -20.0 in-in in 9.4361 Saltbr-in 2.8304 HRD-in -72.51, -49.6 69.57, 9.93 in-in-in SNCiii in-in ActLoopNT-in 2.8276 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.91, 170.94 APE9-dihe-na 61.2, 166.37 APE8-dihe-in -93.43, 149.98 APE8-rot-in 300.62 APE67-dihe-in -69.2, -15.18 -40.28, -54.89 APE12-dist-in 12.6573 APE11-dist-in 10.2948 APE10-dist-in 6.1719 APE9-dist-in 3.1097 C336S None None XRAY 1.04 0.151 0.17 B 364.0 327.0 0 27 27 0 [[40, 325]] 1.0 8qcg CMGC_CSNK2A2_HUMAN CMGC 1e-69 241.0 1.0 301.0 301.0 175 176 177 179 181 69 82 86 154 156 155 157.0 215 202 197 196 195 194 193 192 191 115 Casein kinase II subunit alpha'
CMGC DYRK1A DYR1A_HUMAN 7A4OA Q13627 136 481 763.0 ANP:501 ATPlike Active DFGin 7.4043 15.0335 BLAminus -121.6, 173.77 67.88, 73.96 -92.34, 22.26 284.87, 82.1 -70.26, -21.97 in-in in 8.6845 Saltbr-in 2.7935 HRD-in -65.03, -49.19 79.83, -0.94 in-in-in SNCiii in-in ActLoopNT-in 2.7995 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.61, 174.39 APE9-dihe-na 70.74, 151.67 APE8-dihe-in -72.34, 134.57 APE8-rot-in 295.77 APE67-dihe-in -65.19, -24.46 -43.45, -47.13 APE12-dist-in 10.0985 APE11-dist-in 12.2369 APE10-dist-in 7.723 APE9-dist-in 3.1562 None PTR321 PTR321 XRAY 1.9 0.18 0.203 A 382.0 341.0 5 25 25 0 [[159, 479]] 1.0 7a4o CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7A4OB Q13627 134 481 763.0 ANP:501 ATPlike Inactive DFGin 7.2232 15.0468 BLAminus -127.4, 170.29 72.8, 80.08 -93.18, 24.5 286.73, 76.67 -71.46, -26.03 in-in in 8.3652 Saltbr-in 2.7974 HRD-in -57.9, -49.71 71.19, 2.83 in-in-out SNCiio in-out ActLoopNT-in 2.8396 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -84.65, 164.16 APE9-dihe-na 75.07, 150.77 APE8-dihe-in -68.35, 138.34 APE8-rot-in 298.16 APE67-dihe-in -63.89, -24.74 -46.52, -48.39 APE12-dist-out 14.0969 APE11-dist-in 11.8963 APE10-dist-in 7.5367 APE9-dist-in 3.0281 None PTR321 PTR321 XRAY 1.9 0.18 0.203 B 382.0 341.0 7 25 25 0 [[159, 479]] 1.0 7a4o CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC GSK3B GSK3B_HUMAN 1J1BA P49841 35 388 420.0 ANP:60430 ATPlike Active DFGin 6.7667 13.7876 BLAminus -136.8, -178.88 61.6, 83.12 -97.64, 25.1 286.09, 80.4 -68.7, -13.11 in-in in 8.5659 Saltbr-in 2.59 HRD-in -71.16, -45.98 70.36, 3.88 in-in-in SNCiii in-in ActLoopNT-in 3.0085 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -88.52, 175.26 APE9-dihe-na 75.44, 133.64 APE8-dihe-in -75.76, 147.49 APE8-rot-in 306.57 APE67-dihe-inflip 98.15, -33.72 -56.43, 141.52 APE12-dist-in 13.0562 APE11-dist-in 10.9736 APE10-dist-in 5.8926 APE9-dist-in 3.1122 None None None XRAY 1.8 0.216 0.242 A 420.0 354.0 0 27 27 0 [[56, 340]] 1.0 1j1b CMGC_GSK3B_HUMAN CMGC 3.2e-70 242.8 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 1J1BB P49841 23 386 420.0 ANP:60930 ATPlike Active DFGin 6.6091 13.6686 BLAminus -136.4, -177.03 61.49, 81.88 -98.08, 27.2 288.49, 82.07 -71.33, -13.14 in-in in 8.4573 Saltbr-in 2.713 HRD-in -67.51, -45.87 68.87, 6.43 in-in-in SNCiii in-in ActLoopNT-in 2.9624 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -90.88, 174.17 APE9-dihe-na 76.18, 138.08 APE8-dihe-in -76.12, 141.41 APE8-rot-in 301.11 APE67-dihe-inflip 98.0, -37.59 -54.78, 144.25 APE12-dist-in 12.9784 APE11-dist-in 11.0659 APE10-dist-in 6.0113 APE9-dist-in 3.1744 None None None XRAY 1.8 0.216 0.242 B 420.0 364.0 0 27 27 0 [[56, 340]] 1.0 1j1b CMGC_GSK3B_HUMAN CMGC 3.2e-70 242.8 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 8XN6A P49841 35 384 420.0 ANP:501 ATPlike Active DFGin 6.682 13.8624 BLAminus -137.72, 173.39 67.73, 84.48 -99.84, 22.57 287.77, 80.54 -65.33, -24.58 in-in in 8.4632 Saltbr-in 2.6302 HRD-in -71.05, -47.88 67.82, 15.5 in-in-in SNCiii in-in ActLoopNT-in 3.0543 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.0, 164.43 APE9-dihe-na 85.44, 135.36 APE8-dihe-in -74.2, 151.55 APE8-rot-in 291.81 APE67-dihe-in -69.28, -17.83 -36.59, -67.98 APE12-dist-in 12.9066 APE11-dist-in 10.7867 APE10-dist-in 5.6801 APE9-dist-in 3.1824 None None None XRAY 2.4 0.194 0.242 A 421.0 350.0 0 27 27 0 [[56, 340]] 1.0 8xn6 CMGC_GSK3B_HUMAN CMGC 3.3e-70 242.8 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 8XN6B P49841 26 386 420.0 ANP:501 ATPlike Inactive DFGin 6.5384 13.6503 BLAminus -128.79, 173.26 73.68, 79.74 -95.9, 22.51 291.63, 80.46 -68.54, -21.83 in-in in 8.3292 Saltbr-in 2.8234 HRD-in -66.59, -53.03 79.09, 5.6 in-in-out SNCiio in-out ActLoopNT-in 2.9512 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -88.32, 165.9 APE9-dihe-na 83.63, 132.42 APE8-dihe-in -59.67, 147.17 APE8-rot-out 189.94 APE67-dihe-in -64.51, -21.68 -60.38, -49.59 APE12-dist-in 13.0235 APE11-dist-in 10.9696 APE10-dist-in 5.846 APE9-dist-in 3.0807 None None None XRAY 2.4 0.194 0.242 B 421.0 359.0 2 27 27 0 [[56, 340]] 1.0 8xn6 CMGC_GSK3B_HUMAN CMGC 3.3e-70 242.8 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 1PYXA P49841 35 386 420.0 ANP:1001 ATPlike Active DFGin 6.5838 13.6216 BLAminus -138.81, -178.07 65.18, 79.92 -98.83, 26.07 289.95, 78.27 -73.24, -7.6 in-in in 8.3727 Saltbr-in 2.7648 HRD-in -67.79, -47.84 71.28, 6.53 in-in-in SNCiii in-in ActLoopNT-in 2.9483 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -86.12, 170.17 APE9-dihe-na 80.64, 129.74 APE8-dihe-in -63.79, 140.05 APE8-rot-in 299.48 APE67-dihe-in -56.43, -21.61 -20.65, -80.28 APE12-dist-in 12.9032 APE11-dist-in 10.9366 APE10-dist-in 5.7841 APE9-dist-in 3.1495 None None None XRAY 2.4 0.206 0.233 A 422.0 343.0 9 27 27 0 [[56, 340]] 1.0 1pyx CMGC_GSK3B_HUMAN CMGC 3.3e-70 242.8 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 1PYXB P49841 35 383 420.0 ANP:2001 ATPlike Active DFGin 6.5927 13.7178 BLAminus -140.94, -178.47 65.26, 79.98 -98.11, 22.32 290.75, 76.51 -68.32, -7.73 in-in in 8.4877 Saltbr-in 2.6657 HRD-in -69.98, -47.18 70.83, 5.6 in-in-in SNCiii in-in ActLoopNT-in 2.9383 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -89.3, 169.41 APE9-dihe-na 81.27, 131.24 APE8-dihe-in -66.67, 140.79 APE8-rot-in 300.74 APE67-dihe-in -56.9, -22.2 -20.58, -79.9 APE12-dist-in 12.8382 APE11-dist-in 10.8615 APE10-dist-in 5.7183 APE9-dist-in 3.132 None None None XRAY 2.4 0.206 0.233 B 422.0 338.0 11 27 27 0 [[56, 340]] 1.0 1pyx CMGC_GSK3B_HUMAN CMGC 3.3e-70 242.8 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC MAPK1 MK01_HUMAN 4H3QA P28482 9 360 360.0 ANP:401 ATPlike Inactive DFGin 6.6034 15.6819 BLAminus -131.43, 178.9 70.32, 68.42 -96.0, 22.91 290.2, 68.59 -63.35, -20.75 in-in in 9.2328 Saltbr-in 2.8208 HRD-in -71.26, -48.66 68.7, 4.98 in-in-out SNCiio in-out ActLoopNT-in 2.9419 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioo APE10-dihe-na -133.14, 155.68 APE9-dihe-na -60.56, -35.88 APE8-dihe-out -124.57, -73.58 APE8-rot-out 150.68 APE67-dihe-out -67.06, -6.51 92.51, -9.23 APE12-dist-in 9.1353 APE11-dist-in 11.6615 APE10-dist-out 8.7525 APE9-dist-out 10.9003 R77A,C161S,I255G,E314A None None XRAY 2.2 0.184 0.232 A 362.0 352.0 0 31 31 0 [[25, 313]] 1.0 4h3q CMGC_MAPK1_HUMAN CMGC 3.4e-85 291.8 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6OPGA P28482 10 358 360.0 ANP:60401 ATPlike Active DFGin 6.5353 14.6675 BLAminus -130.49, -173.97 55.35, 72.85 -87.66, 25.26 285.94, 65.79 -65.31, -19.22 in-in in 9.0658 Saltbr-in 2.6952 HRD-in -72.87, -54.34 77.9, 3.87 in-in-in SNCiii in-in ActLoopNT-in 2.7583 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -102.35, 163.88 APE9-dihe-na 79.13, 168.47 APE8-dihe-in -88.92, 138.85 APE8-rot-in 292.11 APE67-dihe-in -68.23, -14.82 -51.35, -45.86 APE12-dist-in 12.5703 APE11-dist-in 11.1338 APE10-dist-in 6.6534 APE9-dist-in 2.9424 None TPO185,PTR187 TPO185,PTR187 XRAY 2.9 0.16 0.239 A 354.0 349.0 0 31 31 0 [[25, 313]] 1.0 6opg CMGC_MAPK1_HUMAN CMGC 8.6e-86 293.8 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 2Y9QA P28482 9 358 360.0 ANP:1359 ATPlike Inactive DFGin 6.7756 15.4463 BLAminus -131.56, -173.58 71.27, 62.6 -94.15, 18.41 284.56, 67.7 -60.61, -22.82 in-in in 9.1065 Saltbr-in 2.7907 HRD-in -69.38, -48.16 75.91, -5.63 in-in-out SNCiio in-out ActLoopNT-in 2.7879 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -136.29, 162.19 APE9-dihe-na -69.67, -30.11 APE8-dihe-in -153.45, 140.36 APE8-rot-out 183.83 APE67-dihe-in -69.16, -12.41 -110.3, 4.7 APE12-dist-in 9.6632 APE11-dist-in 12.83 APE10-dist-out 9.194 APE9-dist-out 11.5088 None None None XRAY 1.55 0.156 0.177 A 362.0 350.0 0 31 31 0 [[25, 313]] 1.0 2y9q CMGC_MAPK1_HUMAN CMGC 9.3e-86 293.7 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4FMQA P28482 9 358 360.0 ANP:401 ATPlike Inactive DFGin 6.797 15.309 BLAminus -133.64, -170.94 67.61, 66.1 -98.24, 21.64 282.65, 68.61 -61.3, -22.42 in-in in 9.1314 Saltbr-in 2.9364 HRD-in -73.07, -47.52 74.25, -10.43 in-in-out SNCiio in-out ActLoopNT-in 2.8302 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -138.4, 159.9 APE9-dihe-na -70.94, -24.68 APE8-dihe-in -158.11, 141.22 APE8-rot-out 179.47 APE67-dihe-in -66.85, -11.48 -113.88, 6.26 APE12-dist-in 9.4738 APE11-dist-in 12.7001 APE10-dist-out 9.2253 APE9-dist-out 11.64 None None None XRAY 2.098 0.182 0.224 A 362.0 350.0 0 31 31 0 [[25, 313]] 1.0 4fmq CMGC_MAPK1_HUMAN CMGC 9.3e-86 293.7 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4NIFB P28482 9 360 360.0 ANP:401 ATPlike Inactive DFGin 6.7638 15.4088 BLAminus -131.87, -169.42 69.51, 63.01 -98.39, 22.71 281.57, 68.87 -63.28, -26.61 in-in in 9.0075 Saltbr-in 2.7834 HRD-in -68.77, -49.09 76.18, -3.84 in-in-out SNCiio in-out ActLoopNT-in 2.7275 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -127.8, 161.08 APE9-dihe-na -75.51, -26.3 APE8-dihe-in -152.23, 138.84 APE8-rot-out 180.18 APE67-dihe-in -71.26, -8.82 -111.88, 5.33 APE12-dist-in 8.1996 APE11-dist-in 11.9615 APE10-dist-out 8.903 APE9-dist-out 11.5131 None None None XRAY 2.15 0.161 0.208 B 362.0 349.0 3 31 28 3 [[25, 313]] 1.0 4nif CMGC_MAPK1_HUMAN CMGC 9.3e-86 293.7 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4NIFE P28482 10 360 360.0 ANP:401 ATPlike Inactive DFGin 6.7991 15.6006 BLAminus -132.52, -168.43 65.68, 64.41 -97.79, 21.09 277.61, 67.0 -63.55, -23.2 in-in in 9.1704 Saltbr-in 2.7133 HRD-in -70.38, -48.01 73.58, -2.52 in-in-out SNCiio in-out ActLoopNT-in 2.7288 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -128.04, 157.14 APE9-dihe-na -71.47, -27.38 APE8-dihe-in -153.58, 137.78 APE8-rot-out 179.37 APE67-dihe-in -68.22, -5.95 -110.7, 4.02 APE12-dist-in 8.1436 APE11-dist-in 11.9289 APE10-dist-out 8.9408 APE9-dist-out 11.5278 None None None XRAY 2.15 0.161 0.208 E 362.0 348.0 3 31 28 3 [[25, 313]] 1.0 4nif CMGC_MAPK1_HUMAN CMGC 9.3e-86 293.7 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8PSRA P28482 1 358 360.0 ANP:401 ATPlike Inactive DFGin 6.7627 15.1158 BLAminus -130.96, -167.28 68.25, 62.57 -95.64, 20.11 282.69, 71.74 -68.98, -15.25 in-in in 8.941 Saltbr-in 2.8232 HRD-in -68.74, -46.55 75.16, -5.99 in-in-out SNCiio in-out ActLoopNT-in 2.7689 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -133.02, 153.53 APE9-dihe-na -66.89, -30.36 APE8-dihe-in -146.2, 134.03 APE8-rot-out 178.25 APE67-dihe-in -71.02, -10.13 -100.56, 5.83 APE12-dist-in 8.1678 APE11-dist-in 11.5467 APE10-dist-out 8.8891 APE9-dist-out 11.3605 None None None XRAY 1.85 0.183 0.209 A 364.0 354.0 4 31 27 4 [[25, 313]] 1.0 8psr CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 3TEIA P28482 10 358 360.0 ANP:401 ATPlike Inactive DFGin 6.743 15.9468 BLAminus -130.8, -176.53 59.31, 74.36 -93.64, 10.5 288.08, 72.41 -50.44, -31.09 in-in in 9.2714 Saltbr-in 3.1994 HRD-in -69.93, -52.25 74.6, -17.82 in-in-out SNCiio in-out ActLoopNT-in 2.7526 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na 66.02, 77.59 APE9-dihe-na -53.11, -45.5 APE8-dihe-in -109.04, 134.77 APE8-rot-out 40.2 APE67-dihe-in -60.63, -33.66 -94.81, 4.48 APE12-dist-in 8.7836 APE11-dist-in 10.9926 APE10-dist-out 8.5071 APE9-dist-out 11.1823 R77A,E314A None None XRAY 2.404 0.199 0.235 A 362.0 339.0 10 31 24 7 [[25, 313]] 1.0 3tei CMGC_MAPK1_HUMAN CMGC 1.6e-85 292.9 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4H3PA P28482 11 359 360.0 ANP:401 ATPlike Inactive DFGin 6.7486 16.129 BLAminus -129.02, -179.26 65.06, 71.95 -98.46, 28.28 294.01, 75.31 -57.14, -23.59 in-in in 9.6015 Saltbr-in 3.0521 HRD-in -79.45, -54.12 78.74, 4.99 in-in-out SNCiio in-out ActLoopNT-in 2.7274 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -109.42, 169.7 APE9-dihe-na -56.98, -72.96 APE8-dihe-in -103.33, 144.18 APE8-rot-out 6.69 APE67-dihe-in -56.41, -28.74 -91.67, -5.29 APE12-dist-in 8.8946 APE11-dist-in 9.1851 APE10-dist-out 8.3832 APE9-dist-out 9.7322 R77A,E314A None None XRAY 2.3 0.18 0.224 A 362.0 342.0 7 31 24 7 [[25, 313]] 1.0 4h3p CMGC_MAPK1_HUMAN CMGC 1.6e-85 292.9 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4H3PD P28482 11 359 360.0 ANP:401 ATPlike Inactive DFGin 6.7423 16.2695 BLAminus -128.42, -178.25 63.92, 70.53 -94.38, 28.0 287.67, 73.89 -60.9, -21.54 in-in in 9.383 Saltbr-in 3.4542 HRD-in -75.51, -54.76 82.18, -2.55 in-in-out SNCiio in-out ActLoopNT-in 2.6568 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 42.36 APE8-rot-out 66.34 APE67-dihe-in -61.9, -28.03 -63.57, -9.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 R77A,E314A None None XRAY 2.3 0.18 0.224 D 362.0 338.0 11 31 20 11 [[25, 313]] 1.0 4h3p CMGC_MAPK1_HUMAN CMGC 1.6e-85 292.9 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8PT0A P28482 11 358 360.0 ANP:401,EAI:403 ATPlike,Allosteric Inactive DFGin 6.7034 15.5181 BLAminus -130.99, -173.26 73.92, 62.07 -95.1, 17.63 279.55, 70.77 -68.45, -13.49 in-in in 9.1413 Saltbr-in 2.8701 HRD-in -71.96, -48.9 77.41, -4.12 in-in-out SNCiio in-out ActLoopNT-in 2.6924 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -110.07, -36.78 APE9-dihe-na -83.86, 177.79 APE8-dihe-in -68.52, 145.31 APE8-rot-out 191.04 APE67-dihe-in -66.51, -15.78 -105.25, 7.42 APE12-dist-out 6.875 APE11-dist-in 12.4434 APE10-dist-out 12.5541 APE9-dist-out 9.9942 None None None XRAY 1.65 0.178 0.207 A 364.0 348.0 0 31 31 0 [[25, 313]] 1.0 8pt0 CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8PT1A P28482 11 359 360.0 ANP:401,E2A:402 ATPlike,Allosteric Inactive DFGin 6.7525 15.486 BLAminus -130.01, -175.04 73.39, 64.08 -95.46, 18.76 282.28, 68.91 -63.67, -19.55 in-in in 9.1894 Saltbr-in 2.8492 HRD-in -70.21, -47.68 76.07, -5.14 in-in-out SNCiio in-out ActLoopNT-in 2.6722 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -121.06, -17.86 APE9-dihe-na -106.9, -177.78 APE8-dihe-in -78.1, 145.34 APE8-rot-out 186.54 APE67-dihe-in -67.62, -15.27 -108.68, 6.96 APE12-dist-in 7.1713 APE11-dist-in 12.6151 APE10-dist-out 12.6307 APE9-dist-out 10.2747 None None None XRAY 1.8 0.18 0.206 A 364.0 349.0 0 31 31 0 [[25, 313]] 1.0 8pt1 CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8PT5A P28482 10 358 360.0 ANP:401,D5R:402 ATPlike,Allosteric Inactive DFGin 6.7902 15.3041 BLAminus -138.03, -165.34 60.19, 62.86 -94.09, 21.06 289.01, 63.44 -59.86, -23.15 in-in in 9.091 Saltbr-in 2.8817 HRD-in -75.18, -47.36 71.89, 2.28 in-in-out SNCiio in-out ActLoopNT-in 2.6856 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -138.15, 158.79 APE9-dihe-na -71.62, -19.38 APE8-dihe-in -154.23, 140.23 APE8-rot-out 183.5 APE67-dihe-in -63.22, -13.66 -125.12, 20.04 APE12-dist-in 7.6307 APE11-dist-in 11.4685 APE10-dist-out 8.7388 APE9-dist-out 11.2872 None None None XRAY 1.95 0.206 0.235 A 364.0 336.0 10 31 21 10 [[25, 313]] 1.0 8pt5 CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8R5FA P28482 11 359 360.0 ANP:401,Y3H:403 ATPlike,Allosteric Inactive DFGin 6.7147 15.4588 BLAminus -133.12, -173.02 67.59, 67.52 -98.89, 23.72 283.56, 67.1 -69.6, -17.36 in-in in 9.1414 Saltbr-in 2.9066 HRD-in -75.1, -48.03 76.68, -4.69 in-in-out SNCiio in-out ActLoopNT-in 2.6928 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -92.27 APE8-dihe-in -89.34, 137.7 APE8-rot-out 190.9 APE67-dihe-in -68.19, -17.69 -92.76, -0.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.6172 None None None XRAY 1.65 0.194 0.218 A 364.0 337.0 12 31 19 12 [[25, 313]] 1.0 8r5f CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8PT3A P28482 10 359 360.0 D7O:401,ANP:405 Allosteric,ATPlike Inactive DFGin 6.7463 16.2954 BLAminus -133.05, 179.18 60.24, 82.09 -94.36, 25.54 283.73, 70.47 -58.59, -24.6 in-out in 9.2783 Saltbr-out 4.0942 HRD-in -70.52, -51.82 77.79, -2.53 out-in-out SNCoio in-out ActLoopNT-in 2.7512 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oiio APE10-dihe-na -134.69, 123.91 APE9-dihe-na -78.34, -33.65 APE8-dihe-in -152.41, 145.11 APE8-rot-out 185.39 APE67-dihe-in -63.56, -20.16 -105.73, 9.6 APE12-dist-out 6.368 APE11-dist-in 8.5922 APE10-dist-in 7.9732 APE9-dist-out 9.8583 None None None XRAY 1.8 0.189 0.222 A 364.0 344.0 6 31 25 6 [[25, 313]] 1.0 8pt3 CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK10 MK10_HUMAN 8WGFA P53779 44 400 464.0 ANP:60401 ATPlike Inactive DFGin 3.6694 14.0402 ABAminus -79.02, -31.55 -136.84, 175.04 -119.07, 8.28 296.56, 96.93 82.35, -157.09 in-out in 9.3841 Saltbr-out 5.0182 HRD-in -58.91, -63.96 74.85, 1.04 out-out-out SNCooo out-out ActLoopNT-out 7.3249 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -90.96, 137.03 APE9-dihe-na -73.55, 128.96 APE8-dihe-in -72.45, 116.03 APE8-rot-in 306.62 APE67-dihe-in -62.34, -20.8 -105.53, -9.26 APE12-dist-out 20.9534 APE11-dist-out 15.692 APE10-dist-out 16.3743 APE9-dist-out 11.0217 None None None XRAY 1.85 0.212 0.266 A 364.0 345.0 4 27 23 4 [[64, 359]] 1.0 8wgf CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1.0 301.0 301.0 206 207 208 210 212 93 111 115 186 188 187 189.0 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 1JNKA P53779 45 400 464.0 ANP:1001 ATPlike Inactive DFGin 3.9285 14.3968 ABAminus -78.22, -57.34 -98.44, 177.55 -110.1, 6.65 294.57, 85.06 91.46, -137.75 in-out in 9.6832 Saltbr-out 4.0755 HRD-in -45.57, -68.64 69.61, 1.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -66.55, 160.68 APE9-dihe-na -118.58, 134.57 APE8-dihe-in -89.41, 118.53 APE8-rot-in 305.71 APE67-dihe-in -40.1, -24.2 -103.88, -20.46 APE12-dist-out 21.3166 APE11-dist-out 17.8726 APE10-dist-out 16.7462 APE9-dist-out 11.4972 None None None XRAY 2.3 0.222 0.274 A 423.0 346.0 5 27 22 5 [[64, 359]] 1.0 1jnk CMGC_MAPK10_HUMAN CMGC 2.3e-85 292.5 1.0 301.0 301.0 206 207 208 210 212 93 111 115 186 188 187 189.0 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 4Z9LA P53779 45 400 464.0 ANP:501,880:502 Allosteric,Type1 Inactive DFGin 4.1741 14.4447 ABAminus -84.27, -25.72 -124.69, 176.34 -117.02, 11.08 300.14, 92.59 64.94, -148.04 out-out out 10.0906 Saltbr-out 4.2056 HRD-in -57.93, -67.24 75.49, -7.3 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 141.12 APE8-dihe-in -74.24, 114.86 APE8-rot-in 306.24 APE67-dihe-in -45.55, -30.35 -108.57, -9.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.617 None None None XRAY 2.1 0.201 0.226 A 364.0 333.0 12 27 17 10 [[64, 359]] 1.0 4z9l CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1.0 301.0 301.0 206 207 208 210 212 93 111 115 186 188 187 189.0 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK12 MK12_HUMAN 1CM8A P53778 8 353 367.0 ANP:60400 ATPlike Active DFGin 6.9648 14.7742 BLAminus -109.08, -177.81 49.88, 82.62 -94.66, 21.96 279.65, 74.31 -61.38, -21.21 in-in in 9.0 Saltbr-in 2.7767 HRD-in -80.35, -48.18 64.34, 20.91 in-in-in SNCiii in-in ActLoopNT-in 2.7927 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.88, 159.85 APE9-dihe-na 73.62, 141.22 APE8-dihe-in -70.32, 134.6 APE8-rot-in 295.09 APE67-dihe-in -62.17, -12.08 -34.13, -61.33 APE12-dist-in 11.6036 APE11-dist-in 10.9558 APE10-dist-in 6.9911 APE9-dist-in 3.072 None TPO183,PTR185 TPO183,PTR185 XRAY 2.4 0.232 0.283 A 367.0 329.0 6 25 25 0 [[27, 311]] 1.0 1cm8 CMGC_MAPK12_HUMAN CMGC 5.6e-85 291.2 1.0 301.0 301.0 170 171 172 174 176 56 74 78 150 152 151 153.0 208 195 190 189 188 187 186 185 184 110 Mitogen-activated protein kinase 12
CMGC MAPK12 MK12_HUMAN 1CM8B P53778 8 353 367.0 ANP:61400 ATPlike Active DFGin 6.9649 14.7941 BLAminus -106.93, -177.79 50.51, 81.99 -94.3, 22.09 279.91, 74.94 -61.07, -21.75 in-in in 9.0314 Saltbr-in 2.7588 HRD-in -80.7, -47.04 63.03, 19.82 in-in-in SNCiii in-in ActLoopNT-in 2.8171 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.88, 160.62 APE9-dihe-na 73.12, 141.25 APE8-dihe-in -70.38, 133.34 APE8-rot-in 295.67 APE67-dihe-in -62.05, -11.85 -33.55, -61.0 APE12-dist-in 11.6132 APE11-dist-in 10.95 APE10-dist-in 6.9956 APE9-dist-in 3.0483 None TPO183,PTR185 TPO183,PTR185 XRAY 2.4 0.232 0.283 B 367.0 329.0 6 25 25 0 [[27, 311]] 1.0 1cm8 CMGC_MAPK12_HUMAN CMGC 5.6e-85 291.2 1.0 301.0 301.0 170 171 172 174 176 56 74 78 150 152 151 153.0 208 195 190 189 188 187 186 185 184 110 Mitogen-activated protein kinase 12
CMGC MAPK7 MK07_HUMAN 4IC7A Q13164 46 400 816.0 ANP:60501 ATPlike Inactive DFGin 6.9627 15.7065 BLAminus -112.54, -170.45 61.6, 71.09 -94.22, 5.13 285.3, 80.28 -60.77, -23.83 in-in in 9.4498 Saltbr-in 2.9107 HRD-in -64.26, -48.71 75.06, -19.07 in-in-out SNCiio in-out ActLoopNT-in 3.1841 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na 163.57, 152.54 APE9-dihe-na -166.15, 155.73 APE8-dihe-in -57.6, 140.19 APE8-rot-out 163.75 APE67-dihe-in -65.59, -38.02 -73.56, -13.59 APE12-dist-in 8.8302 APE11-dist-out 6.3379 APE10-dist-out 8.5089 APE9-dist-in 5.809 None None None XRAY 2.6 0.213 0.258 A 442.0 355.0 0 32 32 0 [[55, 347]] 1.0 4ic7 CMGC_MAPK7_HUMAN CMGC 1.4e-81 280.1 1.0 301.0 301.0 199 200 201 203 205 84 102 106 179 181 180 182.0 244 231 226 225 224 223 222 221 220 138 Mitogen-activated protein kinase 7
CMGC MAPK7 MK07_HUMAN 4IC7D Q13164 47 399 816.0 ANP:60501 ATPlike Inactive DFGin 6.9213 15.4911 BLAminus -111.52, -167.35 56.73, 75.91 -99.28, 4.79 286.66, 84.61 -57.3, -28.24 in-in in 9.3823 Saltbr-in 3.2739 HRD-in -69.27, -53.54 75.02, -19.96 in-in-out SNCiio in-out ActLoopNT-in 3.0429 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -103.14, 107.5 APE9-dihe-na -135.73, 156.83 APE8-dihe-in -63.07, 155.1 APE8-rot-out 142.76 APE67-dihe-in -57.29, -43.39 -78.84, -17.33 APE12-dist-in 8.8303 APE11-dist-out 6.9807 APE10-dist-out 8.3506 APE9-dist-in 5.5697 None None None XRAY 2.6 0.213 0.258 D 442.0 353.0 0 32 32 0 [[55, 347]] 1.0 4ic7 CMGC_MAPK7_HUMAN CMGC 1.4e-81 280.1 1.0 301.0 301.0 199 200 201 203 205 84 102 106 179 181 180 182.0 244 231 226 225 224 223 222 221 220 138 Mitogen-activated protein kinase 7
CMGC MAPK8 MK08_HUMAN 6ZR5A P45983 3 362 427.0 ANP:60402 ATPlike Inactive DFGin 3.8172 14.2258 ABAminus -84.03, -42.55 -114.88, 174.79 -114.82, 8.54 299.13, 101.86 79.5, -168.62 out-out out 10.0023 Saltbr-out 5.0314 HRD-in -56.29, -55.44 70.4, -2.27 out-out-out SNCooo out-out ActLoopNT-out 6.8722 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 107.14 APE8-rot-out 87.08 APE67-dihe-in -67.28, -21.26 -101.91, 26.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.699 0.186 0.256 A 366.0 348.0 12 27 15 12 [[26, 321]] 1.0 6zr5 CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 6ZR5B P45983 4 362 427.0 ANP:60400 ATPlike Inactive DFGin 3.867 14.0721 ABAminus -85.51, -41.13 -110.19, 172.79 -115.96, 8.05 294.61, 92.39 79.48, -170.78 out-out out 10.0205 Saltbr-out 4.2237 HRD-in -59.93, -50.9 67.15, -3.15 out-out-out SNCooo out-out ActLoopNT-out 6.8489 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -100.6, 89.98 APE9-dihe-na -140.16, 151.66 APE8-dihe-in -87.57, 109.71 APE8-rot-in 298.46 APE67-dihe-in -73.45, -13.54 -100.12, 16.22 APE12-dist-out 17.5514 APE11-dist-in 12.8984 APE10-dist-out 16.3414 APE9-dist-out 11.496 None None None XRAY 2.699 0.186 0.256 B 366.0 359.0 0 27 27 0 [[26, 321]] 1.0 6zr5 CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 2XRWA P45983 2 364 427.0 ANP:61367 ATPlike Inactive DFGin 3.8162 13.9414 ABAminus -85.3, -24.5 -153.59, -177.02 -115.68, 7.02 304.14, 97.05 88.01, -156.78 in-out in 9.886 Saltbr-out 4.6349 HRD-in -83.3, -58.4 77.36, -14.29 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.45, -23.57 999.0, -3.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.33 0.166 0.187 A 371.0 347.0 16 27 11 16 [[26, 321]] 1.0 2xrw CMGC_MAPK8_HUMAN CMGC 8.5e-85 290.5 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 2XS0A P45983 6 365 427.0 ANP:1367 ATPlike Inactive DFGin 3.7537 14.0806 ABAminus -75.25, -22.88 -148.14, -178.22 -116.01, 26.92 303.04, 86.85 61.81, -161.42 in-out in 9.7349 Saltbr-out 5.5498 HRD-in -69.33, -60.51 78.49, -20.02 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 173.45 APE8-rot-out 188.87 APE67-dihe-out -73.26, -26.46 -135.55, 95.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T183V,Y185F None None XRAY 2.6 0.194 0.246 A 386.0 346.0 14 27 13 14 [[26, 321]] 1.0 2xs0 CMGC_MAPK8_HUMAN CMGC 4.5e-83 284.9 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 4UX9A P45983 8 363 427.0 ANP:1000 ATPlike Inactive DFGin 6.5081 13.5979 ABAminus -106.9, -65.56 -75.5, 125.74 -123.36, 16.47 304.33, 124.23 -68.62, -34.25 in-out in 8.8495 Saltbr-out 3.6733 HRD-in -62.88, -46.37 73.76, -28.18 out-in-in SNCoii in-in ActLoopNT-in 2.694 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -77.3, -23.46 APE9-dihe-na -71.58, 140.2 APE8-dihe-in -64.86, 127.48 APE8-rot-in 308.5 APE67-dihe-in -60.43, -26.76 -33.69, -61.49 APE12-dist-in 11.784 APE11-dist-in 12.4258 APE10-dist-in 6.6314 APE9-dist-in 4.5326 None None None XRAY 2.34 0.202 0.24 A 364.0 343.0 7 27 22 5 [[26, 321]] 1.0 4ux9 CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 4UX9C P45983 8 363 427.0 ANP:1000 ATPlike Inactive DFGin 6.9564 13.7764 ABAminus -110.49, -64.95 -89.1, 120.63 -119.14, 21.23 309.02, 115.06 -68.23, -26.49 in-out in 8.9193 Saltbr-out 3.6356 HRD-in -66.22, -47.15 71.23, -16.82 out-in-none SNCoin in-none ActLoopNT-in 2.5691 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -79.69, -26.4 APE9-dihe-na -76.07, 142.18 APE8-dihe-in -66.37, 127.01 APE8-rot-in 305.02 APE67-dihe-in -64.57, -24.76 -35.27, -55.26 APE12-dist-none 999.0 APE11-dist-in 12.0054 APE10-dist-in 6.5305 APE9-dist-in 4.6212 None None None XRAY 2.34 0.202 0.24 C 364.0 333.0 15 27 20 7 [[26, 321]] 1.0 4ux9 CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 4UX9D P45983 9 364 427.0 ANP:1000 ATPlike Inactive DFGin 6.7553 13.4065 ABAminus -120.6, -55.98 -93.07, 108.1 -98.68, 25.97 301.07, 117.04 -64.8, -33.9 in-in in 9.3656 Saltbr-in 2.7382 HRD-in -59.8, -49.61 70.57, -12.64 in-in-out SNCiio in-out ActLoopNT-in 2.6695 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oioo APE10-dihe-na -95.31, 105.19 APE9-dihe-na -74.34, -56.46 APE8-dihe-in -76.71, 134.72 APE8-rot-out 95.68 APE67-dihe-out -66.63, -26.9 -139.86, 50.27 APE12-dist-out 14.0313 APE11-dist-in 13.438 APE10-dist-out 10.8234 APE9-dist-out 13.5554 None None None XRAY 2.34 0.202 0.24 D 364.0 344.0 9 27 27 0 [[26, 321]] 1.0 4ux9 CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 8R5EA P45983 5 363 427.0 ANP:402,Y6K:403 ATPlike,Allosteric Inactive DFGin 4.2147 13.8837 ABAminus -92.07, -26.65 -133.67, 178.16 -123.93, 6.5 294.94, 97.33 89.15, -162.77 in-out in 9.5208 Saltbr-out 4.8419 HRD-in -77.17, -59.97 76.05, -10.25 out-out-out SNCooo out-out ActLoopNT-out 6.7895 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -62.14, 143.17 APE9-dihe-na -120.32, 118.65 APE8-dihe-in -75.39, 123.94 APE8-rot-in 299.29 APE67-dihe-in -61.41, -23.9 -115.12, 4.11 APE12-dist-out 18.7072 APE11-dist-out 15.3251 APE10-dist-out 16.6803 APE9-dist-out 11.2441 None None None XRAY 1.7 0.177 0.222 A 366.0 359.0 0 27 27 0 [[26, 321]] 1.0 8r5e CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 4QTDA P45983 6 363 427.0 38Z:424,ANP:425 Type1,Allosteric Inactive DFGin 4.2787 13.95 ABAminus -89.69, -21.2 -135.34, 171.77 -115.48, 9.24 298.02, 89.8 87.52, -156.74 in-out in 9.5926 Saltbr-out 4.1531 HRD-in -75.36, -55.62 72.51, -12.26 out-out-out SNCooo out-out ActLoopNT-out 6.6893 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -117.32, 137.81 APE9-dihe-na -80.42, 132.23 APE8-dihe-in -83.54, 120.1 APE8-rot-in 296.41 APE67-dihe-in -61.39, -20.52 -109.55, -3.05 APE12-dist-out 21.1401 APE11-dist-out 16.032 APE10-dist-out 16.5166 APE9-dist-out 11.1471 None None None XRAY 1.5 0.167 0.192 A 364.0 355.0 3 27 24 3 [[26, 321]] 1.0 4qtd CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 9FT9A P45983 7 363 427.0 ANP:401 ATPlike Inactive DFGin 6.2012 13.6807 BLAminus -138.37, -170.04 58.94, 78.24 -92.66, 22.82 315.32, 103.73 -63.89, -26.18 in-out in 8.5419 Saltbr-out 3.8425 HRD-in -66.92, -47.02 65.13, 0.51 out-in-out SNCoio in-out ActLoopNT-in 2.8271 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -150.17, 156.5 APE9-dihe-na -75.27, -52.01 APE8-dihe-in -88.35, 100.07 APE8-rot-in 310.81 APE67-dihe-in -64.72, -11.39 -102.84, 1.94 APE12-dist-out 5.9095 APE11-dist-in 10.5805 APE10-dist-out 8.0786 APE9-dist-out 10.9491 None None None XRAY 2.35 0.234 0.27 A 360.0 357.0 0 27 27 0 [[26, 321]] 1.0 9ft9 CMGC_MAPK8_HUMAN CMGC 4.1e-84 288.2 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 4UX9B P45983 8 362 427.0 ANP:1000 ATPlike Inactive DFGin 6.8269 14.0009 None -95.23, -79.97 -82.17, 124.02 -113.22, 13.68 297.81, 107.19 -60.29, -32.64 in-in in 8.6029 Saltbr-in 2.9418 HRD-in -59.44, -53.0 79.08, -24.85 in-in-in SNCiii in-in ActLoopNT-in 2.5822 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -58.47, -40.48 APE9-dihe-na -78.17, 138.93 APE8-dihe-in -64.59, 122.35 APE8-rot-in 308.57 APE67-dihe-in -67.83, -19.56 -32.59, -57.13 APE12-dist-in 12.3608 APE11-dist-in 12.1486 APE10-dist-in 6.5271 APE9-dist-in 4.6911 None None None XRAY 2.34 0.202 0.24 B 364.0 327.0 14 27 21 6 [[26, 321]] 1.0 4ux9 CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC PRP4K PRP4K_HUMAN 4IIRA Q13523 668 1005 1007.0 ANP:1101 ATPlike Inactive DFGin 6.3148 14.281 BLAminus -120.02, 179.88 56.46, 83.55 -99.74, 23.13 289.68, 86.8 -67.87, -30.41 in-in in 8.3392 Saltbr-in 2.9099 HRD-in -69.64, -43.63 60.41, 19.82 in-in-out SNCiio in-out ActLoopNT-in 2.7784 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -71.08, 135.09 APE9-dihe-na 76.0, 140.17 APE8-dihe-in -53.9, 125.75 APE8-rot-in 292.63 APE67-dihe-in -65.92, -24.69 -31.89, -51.26 APE12-dist-out 15.6632 APE11-dist-in 11.8049 APE10-dist-out 8.8915 APE9-dist-in 3.1936 None PTR849 PTR849 XRAY 2.0 0.244 0.265 A 358.0 326.0 12 26 26 0 [[687, 1003]] 1.0 4iir CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1.0 301.0 301.0 833 834 835 837 839 717 732 736 812 814 813 815.0 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
CMGC PRP4K PRP4K_HUMAN 4IIRB Q13523 670 1005 1007.0 ANP:1101 ATPlike Inactive DFGin 6.3122 13.999 BLAminus -118.84, -178.78 57.41, 86.51 -103.95, 25.37 293.04, 89.03 -68.57, -33.53 in-in in 8.4814 Saltbr-in 2.7949 HRD-in -68.12, -42.18 57.06, 24.08 in-in-out SNCiio in-out ActLoopNT-in 2.8044 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -73.62, 140.27 APE9-dihe-na 75.42, 141.56 APE8-dihe-in -56.4, 124.9 APE8-rot-in 292.41 APE67-dihe-in -64.45, -24.58 -31.45, -51.6 APE12-dist-out 15.6019 APE11-dist-in 11.8119 APE10-dist-out 8.6042 APE9-dist-in 3.2188 None PTR849 PTR849 XRAY 2.0 0.244 0.265 B 358.0 328.0 8 26 26 0 [[687, 1003]] 1.0 4iir CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1.0 301.0 301.0 833 834 835 837 839 717 732 736 812 814 813 815.0 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
CMGC SRPK1 SRPK1_HUMAN 3BEGA Q96SB4 69 655 655.0 ANP:656 ATPlike Inactive DFGin 5.24 13.8456 BLAminus -114.77, -153.39 33.98, 76.85 -81.15, -2.34 268.31, 108.69 -69.77, 18.55 in-none in 9.9994 Saltbr-none 999.0 HRD-in -104.12, -37.12 72.24, -11.76 none-in-out SNCnio in-out ActLoopNT-in 3.2846 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -116.54, 166.61 APE9-dihe-na 69.15, 140.92 APE8-dihe-in -77.27, 142.01 APE8-rot-out 16.0 APE67-dihe-in -60.83, 1.46 -31.99, -68.49 APE12-dist-in 12.9949 APE11-dist-in 10.441 APE10-dist-in 7.8352 APE9-dist-in 3.0622 None None None XRAY 2.9 0.24 0.298 A 381.0 348.0 21 25 25 0 [[80, 653]] 1.0 3beg CMGC_SRPK1_HUMAN CMGC 1.7e-139 470.1 1.0 301.0 301.0 496 497 498 500 502 109 124 128 210 212 211 213.0 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
OTHER EIF2AK2 E2AK2_HUMAN 2A19B P19525 258 541 551.0 ANP:61640 ATPlike Inactive DFGin 6.2846 14.3355 ABAminus -120.94, -28.83 -115.8, 107.84 -103.04, 22.08 287.72, 80.44 -61.97, -26.4 in-in in 8.2475 Saltbr-in 2.7306 HRD-in -80.45, -51.29 75.68, -7.45 in-in-out SNCiio in-out ActLoopNT-in 3.0605 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -131.92, 139.76 APE9-dihe-na 107.67, -147.72 APE8-dihe-in -73.7, 128.56 APE8-rot-out 9.97 APE67-dihe-in -50.1, -40.95 -103.24, -6.7 APE12-dist-in 12.5447 APE11-dist-in 10.8413 APE10-dist-out 10.3359 APE9-dist-out 9.8523 H412N,C551A TPO446 TPO446 XRAY 2.5 0.234 0.286 B 284.0 262.0 9 27 27 0 [[175, 537]] 1.0 2a19 OTHER_EIF2AK2_HUMAN OTHER 6.2e-47 166.4 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 2A19C P19525 258 541 551.0 ANP:62640 ATPlike Inactive DFGin 6.9406 14.5579 ABAminus -118.27, -31.05 -99.56, 112.7 -116.24, 24.93 286.16, 84.97 -61.15, -35.53 in-in in 7.6955 Saltbr-in 3.4222 HRD-out -95.69, 102.36 -63.67, -30.07 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 H412N,C551A TPO446 TPO446 XRAY 2.5 0.234 0.286 C 284.0 202.0 69 27 5 22 [[175, 537]] 1.0 2a19 OTHER_EIF2AK2_HUMAN OTHER 6.2e-47 166.4 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER TP53RK PRPK_HUMAN 6WQXC Q96S44 17 247 253.0 ANP:301 ATPlike Active DFGin 5.9501 14.2511 BLAminus -146.19, 177.42 55.9, 80.94 -109.82, 15.46 288.95, 83.65 -50.48, -21.92 in-in in 7.4927 Saltbr-in 2.923 HRD-in -69.98, -47.0 96.04, -14.43 in-in-na SNCiia in-na ActLoopNT-in 2.8045 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -67.54, -42.02 APE9-dihe-na -66.2, -40.19 APE8-dihe-na -55.79, -43.62 APE8-rot-na 183.14 APE67-dihe-na -65.72, -35.03 -54.78, -48.19 APE12-dist-na 16.7237 APE11-dist-na 12.0355 APE10-dist-na 14.5766 APE9-dist-na 11.7405 None None None XRAY 2.53 0.214 0.265 C 267.0 231.0 6 23 23 0 [[32, 253]] 1.0 6wqx OTHER_TP53RK_HUMAN TP53RK 1.2e-114 387.3 1.0 224.0 224.0 182 183 184 186 188 60 84 88 159 161 160 162.0 199 205 200 199 198 197 196 195 194 114 EKC/KEOPS complex subunit TP53RK
OTHER TP53RK PRPK_HUMAN 6WQXD Q96S44 18 247 253.0 ANP:301 ATPlike Active DFGin 6.0426 14.258 BLAminus -133.24, 171.19 66.42, 73.64 -108.34, 16.47 289.91, 91.17 -66.2, -15.73 in-in in 7.3772 Saltbr-in 2.5054 HRD-in -60.03, -49.96 100.64, -20.8 in-in-na SNCiia in-na ActLoopNT-in 2.8161 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -66.35, -39.45 APE9-dihe-na -58.51, -49.84 APE8-dihe-na -58.36, -37.8 APE8-rot-na 168.78 APE67-dihe-na -71.45, -37.84 -63.19, -40.46 APE12-dist-na 16.6763 APE11-dist-na 12.0705 APE10-dist-na 14.4989 APE9-dist-na 11.4693 None None None XRAY 2.53 0.214 0.265 D 267.0 230.0 6 23 23 0 [[32, 253]] 1.0 6wqx OTHER_TP53RK_HUMAN TP53RK 1.2e-114 387.3 1.0 224.0 224.0 182 183 184 186 188 60 84 88 159 161 160 162.0 199 205 200 199 198 197 196 195 194 114 EKC/KEOPS complex subunit TP53RK
OTHER WNK1 WNK1_HUMAN 5WDYA Q9H4A3 208 481 2382.0 ANP:901,A6S:902 ATPlike,Type3 None DFGin 7.9646 14.3105 BLAminus -123.5, -167.41 55.36, 79.67 -97.29, 28.92 280.94, 63.73 -64.29, -44.25 out-na out 15.4122 Saltbr-na 999.0 HRD-in -68.16, -49.86 71.58, -14.71 na-in-none SNCain in-none ActLoopNT-in 3.0135 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -108.13, -60.96 999.0, 157.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S378D,E396A,E397A,K398A None None XRAY 2.458 0.231 0.285 A 279.0 260.0 14 26 17 9 [[220, 479]] 1.0 5wdy OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 5WDYB Q9H4A3 206 480 2382.0 ANP:502,A6S:503 ATPlike,Type3 Inactive DFGin 7.3697 14.5039 BLAminus -142.95, -168.2 54.59, 81.56 -95.94, 38.03 311.01, 0.7 -70.23, -38.22 out-na out 15.6644 Saltbr-na 999.0 HRD-in -73.48, -49.35 66.41, -10.51 na-in-out SNCaio in-out ActLoopNT-in 2.8562 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -28.04 APE8-rot-out 62.13 APE67-dihe-out -96.17, -54.53 -53.63, 160.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S378D,E396A,E397A,K398A None None XRAY 2.458 0.231 0.285 B 279.0 259.0 16 26 17 9 [[220, 479]] 1.0 5wdy OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 5WE8A Q9H4A3 209 483 2382.0 ANP:502,A7Y:503 ATPlike,Type3 Inactive DFGin 7.2406 14.0323 BLAminus -121.41, -171.4 57.02, 71.32 -89.03, 25.94 306.74, 15.86 -67.83, -33.81 out-na out 15.5061 Saltbr-na 999.0 HRD-in -66.1, -48.39 70.94, -12.37 na-in-out SNCaio in-out ActLoopNT-in 2.8473 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -77.54, 145.45 APE9-dihe-na 132.01, 166.25 APE8-dihe-in -145.73, 139.85 APE8-rot-out 178.66 APE67-dihe-out -92.59, -40.75 -69.19, 149.7 APE12-dist-out 20.1345 APE11-dist-out 22.4082 APE10-dist-out 25.4016 APE9-dist-out 25.9281 S378D,E396A,E397A,K398A None None XRAY 2.006 0.205 0.247 A 279.0 270.0 5 26 26 0 [[220, 479]] 1.0 5we8 OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 5WE8B Q9H4A3 207 480 2382.0 ANP:502,A7Y:503 ATPlike,Type3 Inactive DFGin 7.5758 14.7327 BLAminus -124.5, -174.3 56.61, 76.82 -93.57, 20.89 272.49, 56.06 -64.65, -35.23 out-na out 15.2517 Saltbr-na 999.0 HRD-in -64.68, -49.22 72.3, -10.07 na-in-out SNCaio in-out ActLoopNT-in 2.8196 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -86.7, 136.01 APE9-dihe-na 147.23, 150.88 APE8-dihe-in -131.74, 126.21 APE8-rot-in 297.77 APE67-dihe-out -91.94, -28.57 -59.79, 145.49 APE12-dist-out 19.935 APE11-dist-out 22.7259 APE10-dist-out 25.875 APE9-dist-out 25.6143 S378D,E396A,E397A,K398A None None XRAY 2.006 0.205 0.247 B 279.0 272.0 2 26 26 0 [[220, 479]] 1.0 5we8 OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 5TF9A Q9H4A3 210 483 2382.0 7AV:501,ANP:502 Type3,ATPlike Inactive DFGin 7.7987 14.8055 BLAminus -124.68, -165.52 44.5, 74.88 -89.64, 28.71 274.12, 71.89 -66.6, -24.41 out-na out 15.6375 Saltbr-na 999.0 HRD-in -62.68, -52.45 73.71, -6.51 na-in-out SNCaio in-out ActLoopNT-in 2.8684 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 175.52 APE8-dihe-in -127.14, 129.36 APE8-rot-out 176.04 APE67-dihe-out -84.82, -53.84 -65.86, 145.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 27.0919 None None None XRAY 2.5 0.198 0.266 A 279.0 262.0 12 26 17 9 [[220, 479]] 1.0 5tf9 OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 5TF9B Q9H4A3 206 480 2382.0 7AV:501,ANP:502 Type3,ATPlike Inactive DFGin 7.7453 14.5813 BLAminus -133.01, -172.41 51.04, 69.52 -83.58, 20.61 265.53, 72.73 -66.77, -27.15 out-na out 14.8615 Saltbr-na 999.0 HRD-in -69.24, -45.67 70.25, -7.52 na-in-out SNCaio in-out ActLoopNT-in 2.9022 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -166.32 APE8-dihe-in -143.09, 133.87 APE8-rot-in 278.07 APE67-dihe-out -99.53, -28.5 -65.98, 144.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 26.5987 None None None XRAY 2.5 0.198 0.266 B 279.0 266.0 9 26 17 9 [[220, 479]] 1.0 5tf9 OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK3 WNK3_HUMAN 5O26A Q9BYP7 135 414 1800.0 ANP:501 ATPlike Active DFGin 6.9535 12.2012 BLAminus -125.28, -164.72 58.79, 65.89 -88.2, 18.66 305.61, 176.73 -69.56, -20.03 out-na out 15.8979 Saltbr-na 999.0 HRD-in -66.1, -48.87 66.45, 11.22 na-in-in SNCaii in-in ActLoopNT-in 3.0206 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.2, 167.0 APE9-dihe-na 127.63, -163.54 APE8-dihe-in -104.53, 119.98 APE8-rot-in 309.3 APE67-dihe-in -64.09, -19.44 -52.49, -34.59 APE12-dist-in 8.8729 APE11-dist-in 11.8288 APE10-dist-in 6.3262 APE9-dist-in 3.7059 None SEP304,SEP308 SEP304,SEP308 XRAY 2.379 0.231 0.278 A 284.0 273.0 7 26 26 0 [[146, 405]] 1.0 5o26 OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1.0 260.0 260.0 293 294 295 297 299 176 194 198 272 274 273 275.0 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
OTHER WNK3 WNK3_HUMAN 5O26B Q9BYP7 136 413 1800.0 ANP:501 ATPlike Active DFGin 7.1821 12.0777 BLAminus -111.0, -167.63 57.49, 63.76 -86.7, 17.71 307.84, 173.05 -70.2, -27.96 out-na out 15.6411 Saltbr-na 999.0 HRD-in -66.99, -53.82 74.22, 8.4 na-in-in SNCaii in-in ActLoopNT-in 3.0727 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.41, 145.08 APE9-dihe-na 140.9, -162.45 APE8-dihe-in -99.46, 120.61 APE8-rot-in 305.94 APE67-dihe-in -65.71, -19.72 -54.06, -31.08 APE12-dist-in 8.1357 APE11-dist-in 11.827 APE10-dist-in 6.0436 APE9-dist-in 3.5099 None SEP304,SEP308 SEP304,SEP308 XRAY 2.379 0.231 0.278 B 284.0 267.0 11 26 26 0 [[146, 405]] 1.0 5o26 OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1.0 260.0 260.0 293 294 295 297 299 176 194 198 272 274 273 275.0 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
STE MAP2K1 MP2K1_HUMAN 5YT3C Q02750 40 382 393.0 ANP:401 ATPlike Inactive DFGin 5.7908 13.7388 BLBplus -158.87, 169.48 60.29, 28.47 -79.68, 102.42 54.67, 117.74 -64.84, 999.0 out-none out 15.4948 Saltbr-none 999.0 HRD-in -68.06, -45.57 70.46, -13.87 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 133.64 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S218D,S222D,T292A,S298A None None XRAY 2.9 0.213 0.289 C 350.0 288.0 55 26 9 17 [[68, 361]] 1.0 5yt3 STE_MAP2K1_HUMAN STE 4.7e-97 330.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 6V2WB Q02750 40 383 393.0 ANP:801 ATPlike Inactive DFGin 5.8394 13.8006 BLBplus -157.59, 169.08 49.06, 44.93 -84.24, 160.32 41.65, 89.8 -73.89, 81.99 out-out out 15.4976 Saltbr-out 15.9009 HRD-in -69.45, -57.02 68.3, 7.65 out-out-out SNCooo out-out ActLoopNT-out 8.701 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -54.4, 144.31 APE9-dihe-na -89.17, -161.86 APE8-dihe-out -115.14, -20.62 APE8-rot-out 48.82 APE67-dihe-out -139.36, 135.26 -146.31, 162.2 APE12-dist-out 17.533 APE11-dist-out 22.7363 APE10-dist-out 24.0164 APE9-dist-out 13.6453 S218A,S222A None None XRAY 3.12 0.189 0.237 B 397.0 312.0 32 26 26 0 [[68, 361]] 1.0 6v2w STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3SLSA Q02750 45 383 393.0 ANP:60400,77D:60500 ATPlike,Type3 Inactive DFGin 6.0671 13.8281 BLBplus -140.19, 178.66 54.09, 43.7 -94.25, 127.95 47.57, 97.28 -65.93, 145.27 out-out out 15.7649 Saltbr-out 16.2192 HRD-in -71.97, -60.22 78.51, -3.12 out-out-out SNCooo out-out ActLoopNT-out 8.4367 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nooo APE10-dihe-na -93.38, -0.96 APE9-dihe-na -118.58, -150.08 APE8-dihe-out -118.64, -9.13 APE8-rot-out 48.38 APE67-dihe-out -141.57, 136.87 -142.17, 156.77 APE12-dist-none 999.0 APE11-dist-out 20.7273 APE10-dist-out 20.2954 APE9-dist-out 13.9168 None None None XRAY 2.3 0.21 0.287 A 304.0 288.0 7 26 20 6 [[68, 361]] 1.0 3sls STE_MAP2K1_HUMAN STE 1.4e-98 335.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3SLSB Q02750 45 383 393.0 ANP:60400,77D:60500 ATPlike,Type3 Inactive DFGin 6.2211 13.8152 BLBplus -143.68, 175.58 56.27, 41.79 -94.32, 130.27 43.79, 91.06 -64.4, 146.65 out-out out 15.8164 Saltbr-out 15.9268 HRD-in -71.99, -58.98 74.88, -1.55 out-out-out SNCooo out-out ActLoopNT-out 7.5058 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nooo APE10-dihe-na -110.34, -17.81 APE9-dihe-na 107.94, -164.16 APE8-dihe-out -114.29, -25.66 APE8-rot-out 168.01 APE67-dihe-out -146.37, 136.37 -123.32, 171.0 APE12-dist-none 999.0 APE11-dist-out 19.1374 APE10-dist-out 21.3033 APE9-dist-out 13.5951 None None None XRAY 2.3 0.21 0.287 B 304.0 290.0 5 26 21 5 [[68, 361]] 1.0 3sls STE_MAP2K1_HUMAN STE 1.4e-98 335.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B3MA Q02750 37 382 393.0 ANP:60402,SU5:60403 ATPlike,Type3 Inactive DFGin 6.1258 13.3704 BLBplus -148.65, 168.81 60.69, 38.17 -87.91, 154.07 39.86, 88.52 -71.49, 59.19 out-out out 15.3138 Saltbr-out 14.9939 HRD-in -70.73, -50.42 71.08, -9.53 out-out-out SNCooo out-out ActLoopNT-out 8.9548 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -121.3 APE8-dihe-out -86.65, -7.6 APE8-rot-out 192.68 APE67-dihe-out -130.89, 138.61 -149.99, 133.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.6751 None None None XRAY 2.3 0.22 0.268 A 326.0 297.0 5 26 21 5 [[68, 361]] 1.0 7b3m STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B3MB Q02750 37 382 393.0 ANP:60402,SU5:60403 ATPlike,Type3 Inactive DFGin 6.095 13.3497 BLBplus -147.84, 168.76 59.95, 38.27 -86.94, 152.02 37.7, 89.9 -70.97, 59.7 out-out out 15.2643 Saltbr-out 14.844 HRD-in -70.51, -50.26 71.48, -11.7 out-out-out SNCooo out-out ActLoopNT-out 8.913 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -133.25 APE8-dihe-out -83.19, -28.76 APE8-rot-in 262.25 APE67-dihe-out -150.63, 137.62 -127.52, 158.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.0843 None None None XRAY 2.3 0.22 0.268 B 326.0 298.0 4 26 22 4 [[68, 361]] 1.0 7b3m STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B7RA Q02750 37 382 393.0 ANP:60401,T1K:60403 ATPlike,Type3 Inactive DFGin 6.1419 13.1685 BLBplus -135.79, 174.07 60.45, 39.3 -91.52, 155.87 43.71, 91.25 -77.25, 65.03 out-out out 15.2989 Saltbr-out 15.4643 HRD-in -68.45, -57.29 78.52, -6.73 out-out-out SNCooo out-out ActLoopNT-out 8.9351 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -104.92 APE8-dihe-out -68.21, -24.42 APE8-rot-out 184.14 APE67-dihe-out -122.45, 137.43 -138.43, 139.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.332 None None None XRAY 1.7 0.195 0.218 A 326.0 297.0 5 26 21 5 [[68, 361]] 1.0 7b7r STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B7RB Q02750 39 382 393.0 ANP:60401,T1K:60403 ATPlike,Type3 Inactive DFGin 6.0337 13.1313 BLBplus -135.72, 177.16 59.39, 36.14 -85.12, 154.58 37.29, 94.77 -80.68, 71.22 out-out out 15.2953 Saltbr-out 15.3776 HRD-in -70.94, -55.67 77.08, -4.68 out-out-out SNCooo out-out ActLoopNT-out 8.8997 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -49.75 APE8-rot-out 171.35 APE67-dihe-out -144.02, 141.19 -140.4, 157.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.195 0.218 B 326.0 295.0 5 26 21 5 [[68, 361]] 1.0 7b7r STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B94A Q02750 37 382 393.0 ANP:60401,T3W:60403 ATPlike,Type3 Inactive DFGin 5.9919 13.4781 BLBplus -132.63, 177.07 57.77, 37.37 -87.97, 156.39 42.38, 94.42 -75.9, 68.49 out-out out 15.5318 Saltbr-out 15.193 HRD-in -65.24, -55.1 71.13, -2.53 out-out-out SNCooo out-out ActLoopNT-out 8.8875 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 176.47 APE8-dihe-out -89.38, 6.07 APE8-rot-in 312.59 APE67-dihe-out -115.47, 140.44 -116.58, 113.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.5994 None None None XRAY 2.0 0.218 0.265 A 326.0 297.0 5 26 21 5 [[68, 361]] 1.0 7b94 STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B94B Q02750 41 382 393.0 ANP:60401,T3W:60403 ATPlike,Type3 Inactive DFGin 5.8527 13.5104 BLBplus -134.32, 175.36 55.61, 39.25 -86.46, 153.65 39.68, 92.62 -72.74, 66.29 out-out out 15.1174 Saltbr-out 14.5478 HRD-in -66.3, -53.58 77.63, -11.98 out-out-out SNCooo out-out ActLoopNT-out 8.6174 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -40.61 APE8-rot-out 185.17 APE67-dihe-out -147.87, 139.4 -127.59, 154.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.218 0.265 B 326.0 293.0 5 26 21 5 [[68, 361]] 1.0 7b94 STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B9LA Q02750 37 382 393.0 ANP:60401,T4N:60402 ATPlike,Type3 Inactive DFGin 6.1432 13.3849 BLBplus -137.56, 174.87 57.48, 45.06 -95.99, 156.93 43.03, 91.55 -78.34, 66.31 out-out out 15.2718 Saltbr-out 15.2434 HRD-in -67.86, -56.92 79.15, -7.52 out-out-none SNCoon out-none ActLoopNT-out 8.9677 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -119.38, 141.01 999.0, 135.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.194 0.214 A 326.0 295.0 7 26 19 7 [[68, 361]] 1.0 7b9l STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B9LB Q02750 41 381 393.0 ANP:60401,T4N:60402 ATPlike,Type3 Inactive DFGin 5.9579 13.456 BLBplus -136.66, 175.43 56.67, 43.08 -92.39, 158.5 42.85, 91.66 -74.84, 62.99 out-out out 15.1558 Saltbr-out 14.9359 HRD-in -69.72, -56.61 80.29, -8.28 out-out-none SNCoon out-none ActLoopNT-out 8.6924 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -146.85, 137.07 999.0, 132.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.194 0.214 B 326.0 291.0 6 26 20 6 [[68, 361]] 1.0 7b9l STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3ORNA Q02750 62 380 393.0 ANP:60001,3OR:60400 ATPlike,Type3 Inactive DFGin 6.0287 13.8039 BLBplus -141.26, -171.81 51.14, 43.91 -94.56, 165.92 40.22, 96.28 -82.7, 73.49 out-out out 15.3451 Saltbr-out 15.2454 HRD-in -75.72, -51.63 76.11, -2.33 out-out-out SNCooo out-out ActLoopNT-out 9.2477 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -90.01, 161.45 APE9-dihe-na 75.09, 172.06 APE8-dihe-out -101.08, -27.15 APE8-rot-out 71.34 APE67-dihe-out -133.03, 139.32 -108.61, 153.73 APE12-dist-out 16.856 APE11-dist-out 20.6225 APE10-dist-out 18.5661 APE9-dist-out 13.0454 None None None XRAY 2.8 0.236 0.277 A 307.0 279.0 8 26 26 0 [[68, 361]] 1.0 3orn STE_MAP2K1_HUMAN STE 9.7e-99 335.8 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3WIGA Q02750 62 380 393.0 ANP:60401,CHU:60403 ATPlike,Type3 Inactive DFGin 6.2646 14.0156 BLBplus -143.18, 168.24 57.0, 43.27 -87.61, 167.58 35.17, 91.44 -81.11, 80.9 out-out out 15.2231 Saltbr-out 15.2345 HRD-in -81.12, -52.72 78.66, -9.66 out-out-out SNCooo out-out ActLoopNT-out 9.2519 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -106.56, 160.96 APE9-dihe-na 79.87, 168.49 APE8-dihe-out -95.77, -24.16 APE8-rot-out 58.57 APE67-dihe-out -134.06, 137.9 -112.83, 153.13 APE12-dist-out 16.5068 APE11-dist-out 20.1486 APE10-dist-out 18.5012 APE9-dist-out 12.9477 None None None XRAY 2.7 0.217 0.25 A 307.0 277.0 10 26 26 0 [[68, 361]] 1.0 3wig STE_MAP2K1_HUMAN STE 9.7e-99 335.8 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4U80A Q02750 62 379 393.0 ANP:60501,3EX:60502 ATPlike,Type3 Inactive DFGin 6.1423 13.3581 BLBplus -137.92, -179.3 57.25, 41.8 -100.21, 164.46 49.55, 87.81 -82.1, 69.9 out-out out 15.3907 Saltbr-out 16.1744 HRD-in -63.5, -60.19 86.1, -12.96 out-out-out SNCooo out-out ActLoopNT-out 9.1744 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnoo APE10-dihe-na 999.0, -56.89 APE9-dihe-na 91.88, -152.59 APE8-dihe-out -126.68, 10.89 APE8-rot-in 310.84 APE67-dihe-out -98.05, 140.26 -155.43, 115.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.5568 APE9-dist-out 13.4268 None None None XRAY 2.8 0.167 0.224 A 341.0 285.0 33 26 23 3 [[68, 361]] 1.0 4u80 STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4LMNA Q02750 62 382 393.0 ANP:60501,EUI:60503 ATPlike,Type3 Inactive DFGin 6.1087 13.4073 BLBplus -150.33, -178.45 56.52, 30.25 -84.69, 155.37 45.37, 87.33 -80.58, 74.43 out-out out 15.5596 Saltbr-out 15.7763 HRD-in -60.71, -57.05 86.56, -12.8 out-out-out SNCooo out-out ActLoopNT-out 9.0127 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -106.36, -106.55 APE9-dihe-na -110.69, -4.9 APE8-dihe-out -94.39, -2.53 APE8-rot-out 38.79 APE67-dihe-out -120.37, 128.01 -144.86, 111.2 APE12-dist-out 20.4741 APE11-dist-out 19.7321 APE10-dist-out 22.049 APE9-dist-out 15.3113 None None None XRAY 2.8 0.193 0.233 A 341.0 291.0 30 26 26 0 [[68, 361]] 1.0 4lmn STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7UMBC Q02750 41 381 393.0 ANP:401,U9F:402 ATPlike,Type3 Inactive DFGin 6.169 13.7668 BLBplus -162.24, 171.11 70.21, 49.7 -113.95, 160.88 44.65, 94.08 -79.06, 81.13 out-out out 15.5589 Saltbr-out 15.2725 HRD-in -66.12, -48.09 76.83, -9.86 out-out-out SNCooo out-out ActLoopNT-out 9.5911 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -127.94, 139.36 APE9-dihe-na -138.86, -160.81 APE8-dihe-out -82.2, -18.64 APE8-rot-out 50.9 APE67-dihe-out -106.39, 139.13 -104.8, 110.61 APE12-dist-out 16.6992 APE11-dist-out 19.6656 APE10-dist-out 21.5701 APE9-dist-out 14.915 None None None XRAY 3.231 0.231 0.268 C 384.0 303.0 38 26 26 0 [[68, 361]] 1.0 7umb STE_MAP2K1_HUMAN STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 6PP9B Q02750 38 383 393.0 ANP:801,LCJ:803 ATPlike,Type3 Inactive DFGin 6.0507 13.8503 BLBplus -152.52, 171.62 57.53, 41.01 -92.48, 164.33 45.1, 87.01 -81.4, 67.83 out-out out 15.4693 Saltbr-out 15.3255 HRD-in -69.19, -57.7 73.02, -1.06 out-out-out SNCooo out-out ActLoopNT-out 8.325 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -150.75, 155.46 APE9-dihe-na -104.35, -179.3 APE8-dihe-out -103.86, -21.71 APE8-rot-out 60.0 APE67-dihe-out -161.36, 138.21 -120.01, -175.99 APE12-dist-out 17.6293 APE11-dist-out 18.0984 APE10-dist-out 21.1907 APE9-dist-out 12.1845 S218A,S222A None None XRAY 2.59 0.222 0.245 B 397.0 314.0 32 26 26 0 [[68, 361]] 1.0 6pp9 STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0VB Q02750 42 383 393.0 ANP:801,EUI:803 ATPlike,Type3 Inactive DFGin 6.0381 13.7379 BLBplus -152.98, 176.74 51.89, 40.05 -97.58, 155.01 48.54, 94.68 -74.32, 76.65 out-out out 15.3562 Saltbr-out 15.2475 HRD-in -53.62, -41.23 79.48, -8.01 out-out-out SNCooo out-out ActLoopNT-out 8.4508 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -59.78, 136.18 APE9-dihe-na -90.07, -164.06 APE8-dihe-out -111.55, -13.91 APE8-rot-out 80.18 APE67-dihe-out -157.27, 123.12 -113.49, 175.2 APE12-dist-out 17.7535 APE11-dist-out 19.5873 APE10-dist-out 21.2162 APE9-dist-out 13.438 S218A,S222A None None XRAY 3.16 0.188 0.234 B 397.0 310.0 32 26 26 0 [[68, 361]] 1.0 7m0v STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0WB Q02750 42 383 393.0 ANP:801,QOA:803 ATPlike,Type3 Inactive DFGin 6.1482 14.0545 BLBplus -157.1, -177.15 57.47, 39.21 -94.37, 139.97 49.64, 89.26 -60.24, 75.28 out-out out 15.239 Saltbr-out 15.1806 HRD-in -60.24, -53.72 67.58, 4.61 out-out-out SNCooo out-out ActLoopNT-out 8.8656 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -57.72, 142.94 APE9-dihe-na -85.2, -169.93 APE8-dihe-out -102.45, -22.28 APE8-rot-out 37.77 APE67-dihe-out -129.82, 144.3 -151.67, 158.88 APE12-dist-out 17.5121 APE11-dist-out 22.6571 APE10-dist-out 23.4774 APE9-dist-out 13.5899 S218A,S222A None None XRAY 3.09 0.197 0.233 B 397.0 310.0 32 26 26 0 [[68, 361]] 1.0 7m0w STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0XB Q02750 40 383 393.0 ANP:801,4BM:803 ATPlike,Type3 Inactive DFGin 6.0399 13.7075 BLBplus -145.13, 173.52 62.48, 32.29 -85.3, 166.26 43.84, 89.91 -82.62, 63.8 out-out out 15.2193 Saltbr-out 15.1277 HRD-in -57.93, -57.46 71.94, -0.74 out-out-out SNCooo out-out ActLoopNT-out 8.3308 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -140.02, 147.44 APE9-dihe-na -87.47, -179.23 APE8-dihe-out -111.82, -15.11 APE8-rot-out 56.07 APE67-dihe-out -151.04, 140.91 -141.23, 175.81 APE12-dist-out 17.7952 APE11-dist-out 17.9191 APE10-dist-out 21.3926 APE9-dist-out 11.9857 S218A,S222A None None XRAY 2.47 0.18 0.215 B 397.0 312.0 32 26 26 0 [[68, 361]] 1.0 7m0x STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0YB Q02750 43 382 393.0 ANP:401,QOM:404 ATPlike,Type3 Inactive DFGin 5.9314 13.9674 BLBplus -158.94, 162.56 56.25, 36.06 -89.69, 147.0 54.27, 82.92 -67.13, 108.1 out-out out 15.4927 Saltbr-out 15.9617 HRD-in -58.74, -61.39 74.04, 6.51 out-out-out SNCooo out-out ActLoopNT-out 9.4018 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -63.76, 140.76 APE9-dihe-na -82.11, -165.89 APE8-dihe-out -109.48, -23.44 APE8-rot-out 48.75 APE67-dihe-out -133.69, 134.38 -151.5, 158.4 APE12-dist-out 17.3805 APE11-dist-out 22.4528 APE10-dist-out 23.379 APE9-dist-out 13.66 S218A,S222A None None XRAY 3.45 0.196 0.218 B 397.0 308.0 32 26 26 0 [[68, 361]] 1.0 7m0y STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0ZB Q02750 42 383 393.0 ANP:401,CHU:402 ATPlike,Type3 Inactive DFGin 6.1064 14.1069 BLBplus -160.77, 175.85 59.87, 41.63 -97.41, 152.84 45.88, 80.73 -66.99, 92.55 out-out out 15.4927 Saltbr-out 15.371 HRD-in -96.91, -40.79 69.65, -8.88 out-out-out SNCooo out-out ActLoopNT-out 9.612 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -66.4, 138.99 APE9-dihe-na -84.75, -165.15 APE8-dihe-out -106.74, -38.37 APE8-rot-out 38.19 APE67-dihe-out -129.38, 138.55 -136.73, 157.33 APE12-dist-out 17.2133 APE11-dist-out 22.3822 APE10-dist-out 23.6126 APE9-dist-out 13.6034 S218A,S222A None None XRAY 3.12 0.193 0.225 B 397.0 310.0 32 26 26 0 [[68, 361]] 1.0 7m0z STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXHA Q02750 39 381 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.113 14.2053 BLBplus -138.52, 176.84 56.32, 45.26 -98.43, 166.79 48.45, 76.71 -79.29, 73.17 out-out out 15.3891 Saltbr-out 15.4608 HRD-in -79.27, -55.22 75.38, 2.3 out-out-out SNCooo out-out ActLoopNT-out 9.3908 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -141.27, 126.74 APE9-dihe-na -91.23, -150.48 APE8-dihe-out -108.84, -16.83 APE8-rot-out 178.7 APE67-dihe-out -130.79, 128.8 -115.86, 151.78 APE12-dist-out 17.4166 APE11-dist-out 17.6237 APE10-dist-out 20.8985 APE9-dist-out 13.1543 None None None XRAY 2.81 0.206 0.253 A 310.0 299.0 0 26 26 0 [[68, 361]] 1.0 9axh STE_MAP2K1_HUMAN STE 1.5e-98 335.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXHB Q02750 38 381 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.0283 13.959 BLBplus -143.4, 172.79 59.61, 49.11 -104.03, 163.1 47.48, 79.51 -74.37, 70.81 out-out out 15.4154 Saltbr-out 14.8168 HRD-in -76.49, -58.47 81.39, -4.23 out-out-out SNCooo out-out ActLoopNT-out 9.3218 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -140.95, 129.53 APE9-dihe-na -95.7, -172.17 APE8-dihe-out -83.87, -23.26 APE8-rot-out 67.32 APE67-dihe-out -134.03, 129.22 -119.03, 156.34 APE12-dist-out 17.3071 APE11-dist-out 17.5745 APE10-dist-out 20.8998 APE9-dist-out 12.718 None None None XRAY 2.81 0.206 0.253 B 310.0 300.0 0 26 26 0 [[68, 361]] 1.0 9axh STE_MAP2K1_HUMAN STE 1.5e-98 335.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXMA Q02750 38 382 393.0 A1AHE:60401,ANP:60403 Type1,ATPlike Inactive DFGin 6.2039 13.9992 BLBplus -146.84, 170.95 57.84, 58.3 -113.46, 158.4 47.1, 81.42 -71.93, 78.64 out-out out 15.4263 Saltbr-out 15.5133 HRD-in -80.25, -54.29 71.05, 3.5 out-out-out SNCooo out-out ActLoopNT-out 9.1102 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -58.81, 135.38 APE9-dihe-na -86.44, -174.93 APE8-dihe-out -114.7, -19.48 APE8-rot-out 61.33 APE67-dihe-out -156.42, 133.96 -137.25, 175.14 APE12-dist-out 17.3471 APE11-dist-out 22.1228 APE10-dist-out 24.2234 APE9-dist-out 13.2409 S218A,S222A None None XRAY 2.42 0.263 0.301 A 310.0 301.0 0 26 26 0 [[68, 361]] 1.0 9axm STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXXA Q02750 41 382 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.1565 14.4729 BLBplus -142.21, 167.57 61.94, 40.19 -92.82, 170.58 38.95, 89.02 -82.21, 74.48 out-out out 15.9248 Saltbr-out 15.6608 HRD-in -77.34, -56.94 85.02, -11.71 out-out-out SNCooo out-out ActLoopNT-out 9.6225 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -70.01, 140.02 APE9-dihe-na -107.63, 178.58 APE8-dihe-out -103.64, -13.88 APE8-rot-out 56.98 APE67-dihe-out -152.18, 145.48 -132.34, 175.09 APE12-dist-out 18.633 APE11-dist-out 16.0857 APE10-dist-out 21.091 APE9-dist-out 12.7711 S218A,S222A None None XRAY 2.07 0.215 0.248 A 310.0 298.0 0 26 26 0 [[68, 361]] 1.0 9axx STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXXC Q02750 37 378 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.0661 14.2508 BLBplus -153.34, 165.37 62.85, 41.08 -93.54, 164.6 44.67, 86.41 -75.31, 71.49 out-out out 15.5167 Saltbr-out 15.0221 HRD-in -80.68, -38.87 53.15, 7.3 out-out-out SNCooo out-out ActLoopNT-out 9.6912 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -68.91, 127.09 APE9-dihe-na -100.27, 169.31 APE8-dihe-out -98.12, -23.61 APE8-rot-out 61.42 APE67-dihe-out -153.77, 146.66 -125.41, 178.29 APE12-dist-out 18.4501 APE11-dist-out 16.1193 APE10-dist-out 21.5812 APE9-dist-out 12.7488 S218A,S222A None None XRAY 2.07 0.215 0.248 C 310.0 297.0 1 26 26 0 [[68, 361]] 1.0 9axx STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AYAB Q02750 42 382 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.2091 14.117 BLBplus -156.4, 169.03 57.59, 47.08 -100.39, 159.82 46.95, 83.0 -73.48, 80.99 out-out out 15.4442 Saltbr-out 14.9574 HRD-in -72.22, -50.64 78.5, -7.92 out-out-out SNCooo out-out ActLoopNT-out 9.725 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -67.32, 133.53 APE9-dihe-na -94.07, -169.54 APE8-dihe-out -110.54, -56.8 APE8-rot-out 71.18 APE67-dihe-out -155.6, 139.89 -98.61, 175.74 APE12-dist-out 17.2211 APE11-dist-out 22.1488 APE10-dist-out 24.1945 APE9-dist-out 13.7662 S218A,S222A None None XRAY 2.59 0.214 0.257 B 310.0 297.0 0 26 26 0 [[68, 361]] 1.0 9aya STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AYAD Q02750 39 382 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.236 14.1136 BLBplus -150.42, 169.48 62.14, 35.37 -84.74, 166.85 39.42, 88.37 -83.08, 73.44 out-out out 15.3824 Saltbr-out 15.2874 HRD-in -84.82, -56.5 86.5, -11.08 out-out-out SNCooo out-out ActLoopNT-out 9.653 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 132.69 APE8-dihe-out -103.38, -24.48 APE8-rot-out 47.89 APE67-dihe-out -161.23, 135.82 -100.94, -174.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.7487 S218A,S222A None None XRAY 2.59 0.214 0.257 D 310.0 293.0 7 26 23 3 [[68, 361]] 1.0 9aya STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AY7B Q02750 33 383 393.0 A1AHE:401,ANP:402 Type1,ATPlike Inactive DFGin 6.1312 14.2675 BLBplus -154.96, 169.08 61.0, 36.72 -91.6, 162.02 49.73, 81.71 -77.61, 77.19 out-out out 15.5132 Saltbr-out 15.4022 HRD-in -75.89, -55.94 83.29, -11.88 out-out-out SNCooo out-out ActLoopNT-out 9.5756 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -66.62, 136.57 APE9-dihe-na -89.93, -175.43 APE8-dihe-out -113.57, -10.62 APE8-rot-out 51.26 APE67-dihe-out -146.5, 144.85 -157.42, 170.13 APE12-dist-out 17.3436 APE11-dist-out 22.1142 APE10-dist-out 24.2068 APE9-dist-out 13.7295 S218A,S222A None None XRAY 2.41 0.203 0.236 B 394.0 322.0 29 26 26 0 [[68, 361]] 1.0 9ay7 STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0UH Q02750 30 380 393.0 CHU:401,ANP:402 Type1,ATPlike Inactive DFGin 6.2263 14.2396 BLBplus -153.68, 170.44 61.41, 47.24 -102.95, 164.39 45.69, 94.01 -79.55, 83.41 out-out out 15.5809 Saltbr-out 15.7853 HRD-in -74.86, -48.68 73.9, -6.25 out-out-out SNCooo out-out ActLoopNT-out 9.583 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -141.84, 152.52 APE9-dihe-na -130.16, 177.33 APE8-dihe-out -105.34, -25.09 APE8-rot-out 37.73 APE67-dihe-out -147.39, 136.35 -136.55, 176.51 APE12-dist-out 17.387 APE11-dist-out 17.659 APE10-dist-out 22.2151 APE9-dist-out 12.9967 S218A,S222A None None XRAY 2.91 0.232 0.264 H 395.0 315.0 36 26 26 0 [[68, 361]] 1.0 9o0u STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0VB Q02750 30 380 393.0 CHU:401,ANP:402 Type1,ATPlike Inactive DFGin 6.1927 14.1253 BLBplus -151.85, 167.5 59.4, 48.24 -102.03, 163.4 46.52, 86.88 -79.89, 84.21 out-out out 15.5955 Saltbr-out 16.8415 HRD-in -72.2, -48.2 74.46, -6.51 out-out-out SNCooo out-out ActLoopNT-out 9.7061 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -135.59, 156.7 APE9-dihe-na -122.67, 146.4 APE8-dihe-out -101.77, -26.6 APE8-rot-in 280.72 APE67-dihe-out -147.98, 135.29 -136.69, 175.09 APE12-dist-out 16.923 APE11-dist-out 17.129 APE10-dist-out 21.8624 APE9-dist-out 12.4292 S218A,S222A None None XRAY 3.5 0.208 0.254 B 395.0 322.0 29 26 26 0 [[68, 361]] 1.0 9o0v STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0VH Q02750 30 380 393.0 CHU:401,ANP:402 Type1,ATPlike Inactive DFGin 6.3491 14.2266 BLBplus -152.81, 169.25 61.22, 47.15 -103.13, 164.19 45.91, 94.17 -79.63, 83.31 out-out out 15.6315 Saltbr-out 15.9163 HRD-in -74.73, -48.72 73.54, -6.07 out-out-out SNCooo out-out ActLoopNT-out 9.5069 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -142.21, 151.98 APE9-dihe-na -130.61, 176.34 APE8-dihe-out -105.52, -25.24 APE8-rot-out 37.89 APE67-dihe-out -147.93, 136.16 -136.73, 176.12 APE12-dist-out 17.2775 APE11-dist-out 17.5835 APE10-dist-out 22.1521 APE9-dist-out 13.0006 S218A,S222A None None XRAY 3.5 0.208 0.254 H 395.0 318.0 33 26 26 0 [[68, 361]] 1.0 9o0v STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4U7ZA Q02750 62 382 393.0 3EW:60502,ANP:60503 Type3,ATPlike Inactive DFGin 6.2159 13.6689 BLBplus -143.34, -175.79 52.44, 38.8 -93.27, 161.31 44.21, 87.69 -81.82, 73.69 out-out out 15.3339 Saltbr-out 16.1402 HRD-in -66.47, -61.07 88.23, -17.21 out-out-out SNCooo out-out ActLoopNT-out 9.1989 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_onoo APE10-dihe-na 999.0, -56.79 APE9-dihe-na 112.87, -133.38 APE8-dihe-out -132.3, 18.52 APE8-rot-out 53.52 APE67-dihe-out -108.34, 133.35 -145.71, 114.06 APE12-dist-out 17.9335 APE11-dist-none 999.0 APE10-dist-out 19.6013 APE9-dist-out 13.9529 None None None XRAY 2.805 0.163 0.214 A 341.0 290.0 31 26 25 1 [[68, 361]] 1.0 4u7z STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4U81A Q02750 62 382 393.0 3EY:60502,ANP:60503 Type3,ATPlike Inactive DFGin 6.3677 13.5745 BLBplus -142.15, -179.17 57.69, 35.98 -93.9, 164.88 44.15, 86.95 -87.34, 72.9 out-out out 15.2755 Saltbr-out 15.4161 HRD-in -63.27, -55.06 80.23, -11.72 out-out-out SNCooo out-out ActLoopNT-out 9.3239 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -28.47 APE9-dihe-na 110.81, -177.13 APE8-dihe-out -114.66, 19.88 APE8-rot-out 189.5 APE67-dihe-out -109.38, 142.31 -159.49, 131.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.6841 APE9-dist-out 12.9691 None None None XRAY 2.701 0.169 0.218 A 341.0 288.0 33 26 23 3 [[68, 361]] 1.0 4u81 STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9ECUB Q02750 43 383 393.0 A1BIS:401,ANP:402 Type3,ATPlike Inactive DFGin 5.9391 13.7784 BLBplus -142.06, 162.17 53.85, 47.21 -95.43, 152.31 51.94, 84.92 -79.97, 96.68 out-out out 15.5116 Saltbr-out 16.1296 HRD-in -66.75, -57.05 86.44, -9.92 out-out-out SNCooo out-out ActLoopNT-out 9.377 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -121.25, 157.88 APE9-dihe-na -135.0, 168.26 APE8-dihe-out -68.75, -42.35 APE8-rot-in 291.8 APE67-dihe-out -146.65, 140.6 -150.67, 174.43 APE12-dist-out 21.121 APE11-dist-out 17.8937 APE10-dist-out 23.1346 APE9-dist-out 13.6562 None None None XRAY 3.46 0.202 0.237 B 393.0 309.0 32 26 26 0 [[68, 361]] 1.0 9ecu STE_MAP2K1_HUMAN STE 2.4e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXYB Q02750 40 383 393.0 A1AHE:401,ANP:402 Type3,ATPlike Inactive DFGin 5.9383 14.1345 BLBplus -149.11, 165.49 51.9, 40.29 -92.3, 159.5 54.58, 76.32 -75.9, 70.87 out-out out 15.3992 Saltbr-out 14.9875 HRD-in -57.0, -47.47 79.88, -10.87 out-out-out SNCooo out-out ActLoopNT-out 9.3372 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -115.09, 128.49 APE9-dihe-na -79.18, 173.05 APE8-dihe-out -111.11, -19.81 APE8-rot-out 47.95 APE67-dihe-out -148.5, 141.81 -130.51, 175.5 APE12-dist-out 18.1758 APE11-dist-out 19.7311 APE10-dist-out 22.7854 APE9-dist-out 13.2287 S218A,S222A None None XRAY 3.6 0.19 0.237 B 394.0 312.0 32 26 26 0 [[68, 361]] 1.0 9axy STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0VD Q02750 31 380 393.0 CHU:401,ANP:402 Type3,ATPlike Inactive DFGin 6.3733 14.325 BLBplus -154.54, 169.16 62.18, 48.49 -103.44, 163.24 44.6, 81.5 -80.27, 83.26 out-out out 16.0835 Saltbr-out 14.6053 HRD-in -72.92, -47.49 72.01, -5.54 out-out-out SNCooo out-out ActLoopNT-out 9.4975 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -145.24, 151.58 APE9-dihe-na -129.14, 150.7 APE8-dihe-out -101.27, -25.48 APE8-rot-in 295.39 APE67-dihe-out -149.5, 133.8 -134.87, 174.51 APE12-dist-out 17.6813 APE11-dist-out 17.5865 APE10-dist-out 22.6132 APE9-dist-out 12.7344 S218A,S222A None None XRAY 3.5 0.208 0.254 D 395.0 315.0 35 26 26 0 [[68, 361]] 1.0 9o0v STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0VF Q02750 30 380 393.0 CHU:401,ANP:402 Type3,ATPlike Inactive DFGin 6.3482 14.2973 BLBplus -150.02, 162.92 66.4, 48.22 -102.89, 163.79 46.62, 89.05 -79.32, 84.9 out-out out 15.5104 Saltbr-out 15.8816 HRD-in -75.24, -46.98 72.8, -6.4 out-out-out SNCooo out-out ActLoopNT-out 9.801 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -127.4, 126.99 APE9-dihe-na -155.92, 117.08 APE8-dihe-out -98.23, -9.95 APE8-rot-in 320.72 APE67-dihe-out -148.49, 134.6 -133.67, 172.28 APE12-dist-out 18.6736 APE11-dist-out 16.7401 APE10-dist-out 21.3436 APE9-dist-out 12.7026 S218A,S222A None None XRAY 3.5 0.208 0.254 F 395.0 322.0 29 26 26 0 [[68, 361]] 1.0 9o0v STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0TB Q02750 42 383 393.0 3EW:401,ANP:402 Type3,ATPlike Inactive DFGin 6.0753 13.7095 BLBplus -159.9, -178.5 64.02, 41.63 -104.3, 143.17 46.34, 100.82 -64.54, 70.24 out-out out 15.4777 Saltbr-out 16.3323 HRD-in -53.73, -55.69 69.68, 5.22 out-out-out SNCooo out-out ActLoopNT-out 8.8715 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -40.91, 141.26 APE9-dihe-na -101.18, -177.28 APE8-dihe-out -68.44, -50.32 APE8-rot-in 321.79 APE67-dihe-out -148.38, 132.66 -145.97, 175.15 APE12-dist-out 17.1657 APE11-dist-out 22.6476 APE10-dist-out 23.7095 APE9-dist-out 13.8641 S218A,S222A None None XRAY 3.19 0.199 0.254 B 397.0 310.0 32 26 26 0 [[68, 361]] 1.0 7m0t STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0UB Q02750 43 385 393.0 QO7:501,ANP:502 Type3,ATPlike Inactive DFGin 6.1782 13.8403 BLBplus -152.87, -177.82 54.02, 43.66 -96.33, 148.45 42.9, 86.91 -71.94, 82.66 out-out out 15.4928 Saltbr-out 15.6637 HRD-in -60.41, -57.85 71.46, -3.21 out-out-out SNCooo out-out ActLoopNT-out 9.0481 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -60.78, 138.09 APE9-dihe-na -86.76, -175.69 APE8-dihe-out -100.26, -15.57 APE8-rot-out 49.06 APE67-dihe-out -118.78, 147.11 -163.65, 150.46 APE12-dist-out 17.2011 APE11-dist-out 22.3588 APE10-dist-out 23.5662 APE9-dist-out 13.6379 S218A,S222A None None XRAY 3.09 0.193 0.23 B 397.0 311.0 32 26 26 0 [[68, 361]] 1.0 7m0u STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 5YT3B Q02750 40 382 393.0 ANP:401 ATPlike Inactive DFGin 5.8963 14.534 None -102.15, -169.78 -40.15, 149.52 -75.91, 143.56 303.08, 84.8 -64.88, 94.03 out-out out 16.3586 Saltbr-out 14.8656 HRD-out -104.42, 23.77 -144.46, 111.13 out-out-out SNCooo out-out ActLoopNT-out 8.0209 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -80.58, -32.09 APE9-dihe-na -86.11, -15.83 APE8-dihe-out 58.15, 64.44 APE8-rot-in 310.76 APE67-dihe-out -122.56, 143.11 -138.66, 139.98 APE12-dist-out 19.0552 APE11-dist-out 14.0554 APE10-dist-out 18.8403 APE9-dist-out 25.9099 S218D,S222D,T292A,S298A None None XRAY 2.9 0.213 0.289 B 350.0 311.0 32 26 26 0 [[68, 361]] 1.0 5yt3 STE_MAP2K1_HUMAN STE 4.7e-97 330.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 5YT3D Q02750 39 382 393.0 ANP:401 ATPlike Inactive DFGin 5.7501 14.7176 None -77.53, 172.31 -71.81, 159.92 -66.82, 141.72 314.31, 87.77 -59.96, 135.61 out-out out 16.8715 Saltbr-out 15.0058 HRD-out -106.97, -11.01 -97.02, 107.72 out-out-out SNCooo out-out ActLoopNT-out 8.2442 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -63.82, -51.0 APE9-dihe-na -70.37, -13.35 APE8-dihe-out 47.35, 74.88 APE8-rot-out 143.99 APE67-dihe-out -134.73, 126.26 -143.64, 140.67 APE12-dist-out 19.3394 APE11-dist-out 14.3822 APE10-dist-out 19.1547 APE9-dist-out 26.1684 S218D,S222D,T292A,S298A None None XRAY 2.9 0.213 0.289 D 350.0 309.0 35 26 26 0 [[68, 361]] 1.0 5yt3 STE_MAP2K1_HUMAN STE 4.7e-97 330.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 5YT3A Q02750 39 382 393.0 ANP:401 ATPlike Inactive DFGinter 6.3567 10.3827 None -128.68, 173.26 63.68, 38.66 -52.93, -21.76 28.6, 36.22 -61.84, 114.84 out-out out 16.3153 Saltbr-out 14.589 HRD-in -77.7, -42.23 58.41, 13.61 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 70.97 APE8-rot-none 999.0 APE67-dihe-out -132.4, 139.8 -149.07, 91.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S218D,S222D,T292A,S298A None None XRAY 2.9 0.213 0.289 A 350.0 297.0 47 26 12 14 [[68, 361]] 1.0 5yt3 STE_MAP2K1_HUMAN STE 4.7e-97 330.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7F2XA Q02750 45 382 393.0 ANP:60501 ATPlike Inactive None 14.5783 16.4961 None -71.03, 160.3 -74.32, 105.83 -69.14, -7.13 285.96, 1.01 -79.69, -8.9 out-out out 16.3606 Saltbr-out 16.8732 HRD-out -123.25, -2.01 -136.26, 151.99 out-out-out SNCooo out-out ActLoopNT-out 10.3746 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -84.56, -47.24 APE9-dihe-na 151.04, 109.57 APE8-dihe-in -68.48, 129.23 APE8-rot-in 304.12 APE67-dihe-out -103.66, 129.16 -127.47, 104.31 APE12-dist-out 14.4563 APE11-dist-out 17.6728 APE10-dist-out 20.3077 APE9-dist-out 25.5229 None None None XRAY 2.007 0.216 0.232 A 321.0 300.0 0 26 26 0 [[68, 361]] 1.0 7f2x STE_MAP2K1_HUMAN STE 1.4e-97 332.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K4 MP2K4_HUMAN 3ALNA P45985 83 389 399.0 ANP:1 ATPlike Inactive DFGin 6.5172 13.3925 BLBplus -161.78, 169.91 72.82, 15.08 -92.63, 122.04 60.81, 71.89 121.07, -111.8 out-na out 15.5254 Saltbr-na 999.0 HRD-in -50.15, -58.45 86.79, 0.09 na-out-none SNCaon out-none ActLoopNT-out 11.0944 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.289 0.378 A 327.0 270.0 37 27 7 20 [[102, 367]] 1.0 3aln STE_MAP2K4_HUMAN STE 6.8e-86 293.8 4.0 257.0 254.0 246 247 248 250 252 131 148 152 226 228 227 229.0 289 273 268 267 266 265 264 263 262 179 Dual specificity mitogen-activated protein kinase kinase 4
STE MAP2K4 MP2K4_HUMAN 3ALNB P45985 84 390 399.0 ANP:1 ATPlike Inactive DFGin 7.0625 13.6128 BLBplus -140.58, 160.03 87.63, 22.27 -95.55, 159.55 58.77, 88.3 94.56, -147.05 out-na out 15.2673 Saltbr-na 14.9486 HRD-in -87.89, -53.1 65.57, 1.61 na-out-none SNCaon out-none ActLoopNT-out 8.2553 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.289 0.378 B 327.0 263.0 44 27 8 19 [[102, 367]] 1.0 3aln STE_MAP2K4_HUMAN STE 6.8e-86 293.8 4.0 257.0 254.0 246 247 248 250 252 131 148 152 226 228 227 229.0 289 273 268 267 266 265 264 263 262 179 Dual specificity mitogen-activated protein kinase kinase 4
STE MAP2K4 MP2K4_HUMAN 3ALOA P45985 95 389 399.0 ANP:406 ATPlike Inactive DFGin 6.8866 13.7295 BLBplus -112.59, -177.7 66.85, 21.6 -92.73, 167.28 50.76, 92.54 73.18, -126.21 out-na out 15.8896 Saltbr-na 16.4758 HRD-in -52.75, -64.74 82.96, 2.2 na-out-out SNCaoo out-out ActLoopNT-out 8.2573 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na -57.34, 98.51 APE9-dihe-na 135.89, -16.86 APE8-dihe-out -126.39, -33.94 APE8-rot-na 70.02 APE67-dihe-out -48.7, -17.03 -94.49, 137.34 APE12-dist-out 18.4542 APE11-dist-out 19.5165 APE10-dist-out 20.4949 APE9-dist-out 23.0257 None None None XRAY 2.6 0.209 0.271 A 327.0 289.0 6 27 27 0 [[102, 367]] 1.0 3alo STE_MAP2K4_HUMAN STE 6.8e-86 293.8 4.0 257.0 254.0 246 247 248 250 252 131 148 152 226 228 227 229.0 289 273 268 267 266 265 264 263 262 179 Dual specificity mitogen-activated protein kinase kinase 4
STE MAP2K4 MP2K4_HUMAN 3ALNC P45985 100 390 399.0 ANP:1 ATPlike Inactive None 999.0 11.66 None -139.2, 85.12 54.71, 167.37 -67.61, 999.0 74.38, 108.84 999.0, 999.0 none-na none 999.0 Saltbr-na 999.0 HRD-none 999.0, 999.0 999.0, 999.0 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.289 0.378 C 327.0 183.0 108 27 2 25 [[102, 367]] 1.0 3aln STE_MAP2K4_HUMAN STE 6.8e-86 293.8 4.0 257.0 254.0 246 247 248 250 252 131 148 152 226 228 227 229.0 289 273 268 267 266 265 264 263 262 179 Dual specificity mitogen-activated protein kinase kinase 4
STE MAP4K1 M4K1_HUMAN 6CQDA Q92918 2 293 833.0 ANP:60301 ATPlike Inactive DFGin 6.0316 13.8855 BLAminus -140.97, 178.85 65.6, 83.06 -106.07, 25.72 286.0, 93.85 -58.74, -52.87 in-in in 8.5882 Saltbr-in 2.603 HRD-in -75.86, -49.25 70.86, -6.64 in-out-out SNCioo out-out ActLoopNT-out 5.6118 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -107.43, -47.34 APE9-dihe-na -128.13, -155.64 APE8-dihe-in -106.29, 135.18 APE8-rot-out 173.28 APE67-dihe-in -57.05, -28.95 -70.03, -34.9 APE12-dist-out 19.7103 APE11-dist-out 23.5071 APE10-dist-out 22.0831 APE9-dist-out 27.3122 None None None XRAY 2.12 0.206 0.25 A 297.0 288.0 4 28 28 0 [[17, 274]] 1.0 6cqd STE_MAP4K1_HUMAN STE 4.2e-92 314.0 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6CQDB Q92918 4 293 833.0 ANP:60302 ATPlike Inactive DFGin 6.1011 14.2293 BLAminus -144.26, -175.8 58.68, 77.54 -93.97, 33.74 292.79, 90.96 -66.13, -50.88 in-in in 9.463 Saltbr-in 3.2089 HRD-in -76.3, -46.87 66.26, 5.48 in-out-out SNCioo out-out ActLoopNT-out 6.073 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -81.26, 126.5 APE9-dihe-na -81.79, -144.73 APE8-dihe-in -66.65, 145.16 APE8-rot-out 188.81 APE67-dihe-in -66.31, -22.65 -105.18, -2.62 APE12-dist-out 20.7631 APE11-dist-out 21.9588 APE10-dist-out 21.4095 APE9-dist-out 27.357 None None None XRAY 2.12 0.206 0.25 B 297.0 290.0 0 28 28 0 [[17, 274]] 1.0 6cqd STE_MAP4K1_HUMAN STE 4.2e-92 314.0 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K4 M4K4_HUMAN 4U40A O95819 17 311 1239.0 ANP:401 ATPlike Inactive DFGin 3.8374 14.3902 BLBplus -136.79, 156.81 66.63, 45.06 -75.84, 145.72 56.03, 93.39 -61.09, 117.37 out-out out 11.6402 Saltbr-out 10.4893 HRD-in -68.35, -49.63 65.89, 2.04 out-out-out SNCooo out-out ActLoopNT-out 9.6283 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -76.11, -36.45 APE9-dihe-na 89.46, 175.41 APE8-dihe-in -63.67, 133.35 APE8-rot-out 188.73 APE67-dihe-in -61.71, -22.93 -96.09, -7.57 APE12-dist-out 14.8768 APE11-dist-out 14.965 APE10-dist-out 15.9776 APE9-dist-out 9.4768 None None None XRAY 2.3 0.201 0.262 A 332.0 295.0 0 28 28 0 [[25, 289]] 1.0 4u40 STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
STE OXSR1 OXSR1_HUMAN 3DAKA O95747 6 295 527.0 ANP:1 ATPlike Inactive DFGin 5.1294 16.1767 BLBtrans -100.04, 163.42 76.18, 16.7 -60.44, 136.33 171.32, 70.03 96.86, -127.31 out-out out 12.5845 Saltbr-out 12.035 HRD-in -76.04, -45.57 81.12, -26.2 out-out-out SNCooo out-out ActLoopNT-out 8.169 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -91.06 APE9-dihe-na 161.92, -137.1 APE8-dihe-in -95.05, 112.91 APE8-rot-in 254.7 APE67-dihe-in -56.68, -24.99 -85.34, 38.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 29.3838 APE9-dist-out 30.0509 None None None XRAY 2.25 0.199 0.267 A 290.0 279.0 11 33 22 11 [[17, 291]] 1.0 3dak STE_OXSR1_HUMAN STE 6e-94 320.1 1.0 257.0 257.0 163 164 165 167 169 46 63 67 143 145 144 146.0 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 3DAKB O95747 6 295 527.0 ANP:1 ATPlike Inactive DFGin 5.3319 16.237 BLBtrans -104.22, 159.58 79.05, 11.08 -51.8, 136.57 175.99, 64.12 96.31, -131.54 out-out out 12.4558 Saltbr-out 12.0827 HRD-in -78.09, -47.02 83.9, -24.13 out-out-none SNCoon out-none ActLoopNT-out 8.147 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 130.99 APE8-rot-in 294.38 APE67-dihe-in -53.25, -31.09 -85.79, 34.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.25 0.199 0.267 B 290.0 278.0 12 33 21 12 [[17, 291]] 1.0 3dak STE_OXSR1_HUMAN STE 6e-94 320.1 1.0 257.0 257.0 163 164 165 167 169 46 63 67 143 145 144 146.0 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 3DAKC O95747 7 295 527.0 ANP:1 ATPlike Inactive DFGin 5.2 16.258 BLBtrans -99.19, 165.37 77.39, 13.36 -54.55, 139.89 174.92, 66.03 90.2, -129.87 out-out out 12.7953 Saltbr-out 12.192 HRD-in -79.55, -55.89 92.02, -15.23 out-out-out SNCooo out-out ActLoopNT-out 8.0721 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -81.49, 148.28 APE9-dihe-na 113.95, 160.67 APE8-dihe-in -84.39, 122.06 APE8-rot-out 195.33 APE67-dihe-in -62.35, -26.54 -78.99, 38.41 APE12-dist-out 26.3253 APE11-dist-out 28.8507 APE10-dist-out 33.354 APE9-dist-out 31.6785 None None None XRAY 2.25 0.199 0.267 C 290.0 281.0 8 33 25 8 [[17, 291]] 1.0 3dak STE_OXSR1_HUMAN STE 6e-94 320.1 1.0 257.0 257.0 163 164 165 167 169 46 63 67 143 145 144 146.0 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 3DAKD O95747 7 295 527.0 ANP:1 ATPlike Inactive DFGin 5.5213 16.5996 BLBtrans -91.03, 168.13 66.29, 18.87 -59.74, 133.08 178.71, 62.0 94.13, -120.8 out-out out 12.7384 Saltbr-out 12.0313 HRD-in -82.87, -52.16 83.38, -16.35 out-out-out SNCooo out-out ActLoopNT-out 8.2495 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -78.42, 169.6 APE9-dihe-na 94.12, 158.49 APE8-dihe-in -86.45, 138.34 APE8-rot-out 182.04 APE67-dihe-in -59.03, -28.5 -85.94, 35.36 APE12-dist-none 999.0 APE11-dist-out 29.8075 APE10-dist-out 33.4887 APE9-dist-out 31.9154 None None None XRAY 2.25 0.199 0.267 D 290.0 284.0 5 33 28 5 [[17, 291]] 1.0 3dak STE_OXSR1_HUMAN STE 6e-94 320.1 1.0 257.0 257.0 163 164 165 167 169 46 63 67 143 145 144 146.0 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 2VWIB O95747 9 292 527.0 ANP:1295 ATPlike Inactive DFGin 5.287 16.4266 BLBtrans -100.18, 160.58 80.18, 12.17 -59.65, 137.68 171.88, 72.09 96.85, -127.69 out-out out 12.997 Saltbr-out 12.2057 HRD-in -71.44, -47.93 86.11, -20.42 out-out-none SNCoon out-none ActLoopNT-out 7.9668 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 75.95 APE8-rot-in 320.74 APE67-dihe-in -62.37, -32.44 -100.52, 20.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.15 0.253 0.287 B 303.0 264.0 20 33 21 12 [[17, 291]] 1.0 2vwi STE_OXSR1_HUMAN STE 7.1e-94 319.8 1.0 257.0 257.0 163 164 165 167 169 46 63 67 143 145 144 146.0 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 2VWIC O95747 9 292 527.0 ANP:1294 ATPlike Inactive DFGin 5.3005 16.2283 BLBtrans -96.83, 164.86 72.67, 17.81 -61.87, 137.0 171.22, 69.43 96.65, -124.96 out-out out 12.8178 Saltbr-out 12.4351 HRD-in -77.27, -48.25 84.09, -19.76 out-out-out SNCooo out-out ActLoopNT-out 7.9777 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 143.21 APE9-dihe-na 99.05, -143.58 APE8-dihe-in -115.19, 90.11 APE8-rot-out 49.11 APE67-dihe-in -67.35, -20.96 -80.96, 15.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 29.0871 APE9-dist-out 29.4078 None None None XRAY 2.15 0.253 0.287 C 303.0 271.0 13 33 28 5 [[17, 291]] 1.0 2vwi STE_OXSR1_HUMAN STE 7.1e-94 319.8 1.0 257.0 257.0 163 164 165 167 169 46 63 67 143 145 144 146.0 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 2VWID O95747 6 298 527.0 ANP:1300 ATPlike Inactive DFGin 5.1794 16.2232 BLBtrans -101.51, 161.03 73.3, 16.0 -58.73, 139.72 167.14, 71.27 94.08, -129.9 out-out out 12.6631 Saltbr-out 12.4112 HRD-in -67.92, -49.61 77.45, -14.4 out-out-out SNCooo out-out ActLoopNT-out 7.9431 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -84.67, 122.36 APE9-dihe-na 118.58, -169.41 APE8-dihe-in -120.4, 114.0 APE8-rot-in 321.26 APE67-dihe-in -59.9, -22.77 -41.25, -46.54 APE12-dist-out 29.1338 APE11-dist-out 28.0731 APE10-dist-out 29.3143 APE9-dist-out 29.1611 None None None XRAY 2.15 0.253 0.287 D 303.0 284.0 9 33 24 9 [[17, 291]] 1.0 2vwi STE_OXSR1_HUMAN STE 7.1e-94 319.8 1.0 257.0 257.0 163 164 165 167 169 46 63 67 143 145 144 146.0 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 2VWIA O95747 13 292 527.0 ANP:1294 ATPlike Inactive DFGin 8.898 15.6012 None -61.18, 158.62 -55.34, 143.64 -131.37, -0.25 74.39, 103.15 -56.05, -46.66 none-none none 999.0 Saltbr-none 999.0 HRD-in -71.19, -49.86 82.28, -11.12 none-out-out SNCnoo out-out ActLoopNT-out 5.9984 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -154.6 APE8-dihe-in -114.29, 105.56 APE8-rot-out 57.55 APE67-dihe-in -58.83, -26.11 -92.35, 9.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 28.1357 None None None XRAY 2.15 0.253 0.287 A 303.0 237.0 43 33 18 15 [[17, 291]] 1.0 2vwi STE_OXSR1_HUMAN STE 7.1e-94 319.8 1.0 257.0 257.0 163 164 165 167 169 46 63 67 143 145 144 146.0 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE PAK1 PAK1_HUMAN 3Q4ZA Q13153 251 545 545.0 ANP:60800 ATPlike None DFGin 6.0861 15.9823 BLAminus -129.5, -163.35 61.16, 72.73 -92.37, 13.66 295.77, 79.36 -60.94, -29.11 out-none out 10.1866 Saltbr-none 999.0 HRD-in -71.1, -48.5 65.7, -2.93 none-in-in SNCnii in-in ActLoopNT-in 2.7668 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.35, 142.5 APE9-dihe-na 131.45, -160.89 APE8-dihe-in -120.18, 125.75 APE8-rot-in 304.74 APE67-dihe-in -64.8, -21.76 -41.32, -52.02 APE12-dist-in 9.9567 APE11-dist-in 11.7432 APE10-dist-in 6.0277 APE9-dist-in 3.3321 S259I,K299R,D389N,L516I None None XRAY 1.887 0.186 0.231 A 306.0 281.0 12 28 28 0 [[270, 521]] 1.0 3q4z STE_PAK1_HUMAN STE 2e-93 318.4 1.0 257.0 257.0 406 407 408 410 412 299 315 319 386 388 387 389.0 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK4 PAK4_HUMAN 4FIFA O96013 296 589 591.0 ANP:1000 ATPlike Active DFGin 6.1318 13.8794 BLAminus -134.27, -172.64 55.78, 65.69 -91.22, 11.11 299.57, 98.92 -61.37, -20.58 in-in in 7.0457 Saltbr-in 3.1118 HRD-in -73.18, -47.2 74.11, -8.39 in-in-in SNCiii in-in ActLoopNT-in 2.8521 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.08, 134.89 APE9-dihe-na 136.18, -173.61 APE8-dihe-in -102.98, 119.55 APE8-rot-in 312.46 APE67-dihe-in -69.75, -26.2 -30.93, -52.34 APE12-dist-in 9.3183 APE11-dist-in 11.709 APE10-dist-in 5.8745 APE9-dist-in 3.2985 None SEP474 SEP474 XRAY 2.6 0.207 0.227 A 346.0 294.0 0 28 28 0 [[321, 572]] 1.0 4fif STE_PAK4_HUMAN STE 3.1e-88 301.5 5.0 257.0 253.0 457 458 459 461 463 350 366 370 437 439 438 440.0 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIFB O96013 297 589 591.0 ANP:1000 ATPlike Active DFGin 5.8992 13.8496 BLAminus -129.09, -170.37 52.27, 68.51 -93.51, 10.45 301.97, 96.23 -63.09, -15.01 in-in in 7.0072 Saltbr-in 3.1674 HRD-in -65.39, -48.9 75.1, -7.5 in-in-in SNCiii in-in ActLoopNT-in 2.8012 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.88, 134.77 APE9-dihe-na 136.42, -174.06 APE8-dihe-in -101.96, 121.94 APE8-rot-in 314.36 APE67-dihe-in -72.79, -21.56 -33.03, -50.98 APE12-dist-in 9.2381 APE11-dist-in 11.7116 APE10-dist-in 5.8859 APE9-dist-in 3.3353 None SEP474 SEP474 XRAY 2.6 0.207 0.227 B 346.0 293.0 0 28 28 0 [[321, 572]] 1.0 4fif STE_PAK4_HUMAN STE 3.1e-88 301.5 5.0 257.0 253.0 457 458 459 461 463 350 366 370 437 439 438 440.0 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIGA O96013 298 590 591.0 ANP:1001 ATPlike Inactive DFGin 5.9761 13.9947 BLAminus -134.45, -166.25 59.06, 57.3 -88.34, 9.13 298.9, 106.14 -61.58, -20.66 in-in in 7.1335 Saltbr-in 3.1682 HRD-in -77.25, -46.66 72.07, -3.1 in-in-out SNCiio in-out ActLoopNT-in 2.8596 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.47, 161.1 APE9-dihe-na 110.61, 163.55 APE8-dihe-in -79.54, 130.34 APE8-rot-out 29.96 APE67-dihe-in -76.38, -28.34 -35.31, -49.63 APE12-dist-in 9.4183 APE11-dist-in 11.5692 APE10-dist-in 5.6353 APE9-dist-in 3.3687 None SEP474 SEP474 XRAY 3.01 0.197 0.221 A 346.0 293.0 0 28 28 0 [[321, 572]] 1.0 4fig STE_PAK4_HUMAN STE 3.1e-88 301.5 5.0 257.0 253.0 457 458 459 461 463 350 366 370 437 439 438 440.0 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4JDIA O96013 300 589 591.0 ANP:1000 ATPlike Active DFGin 6.2908 14.4701 BLAminus -134.26, 177.87 63.72, 71.58 -94.6, 13.78 289.77, 79.71 -54.15, -28.77 in-in in 6.9588 Saltbr-in 2.7368 HRD-in -72.82, -49.09 73.48, 2.76 in-in-in SNCiii in-in ActLoopNT-in 2.8295 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.62, 145.0 APE9-dihe-na 130.41, -160.49 APE8-dihe-in -120.53, 123.45 APE8-rot-in 305.94 APE67-dihe-in -63.49, -22.51 -36.89, -56.07 APE12-dist-in 8.7694 APE11-dist-in 11.535 APE10-dist-in 5.8739 APE9-dist-in 3.3267 None SEP474 SEP474 XRAY 1.85 0.194 0.233 A 346.0 290.0 0 28 28 0 [[321, 572]] 1.0 4jdi STE_PAK4_HUMAN STE 3.1e-88 301.5 5.0 257.0 253.0 457 458 459 461 463 350 366 370 437 439 438 440.0 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 5UPKB O96013 300 588 591.0 ANP:60600 ATPlike Active DFGin 6.2722 14.1391 BLAminus -132.3, -169.35 61.71, 61.5 -87.86, 7.28 293.59, 93.96 -55.36, -28.3 in-in in 7.0771 Saltbr-in 3.3293 HRD-in -65.35, -49.16 70.36, 11.54 in-in-in SNCiii in-in ActLoopNT-in 2.9972 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.55, 149.52 APE9-dihe-na 120.09, -163.11 APE8-dihe-in -119.51, 121.87 APE8-rot-in 313.98 APE67-dihe-in -69.89, -18.98 -32.47, -57.41 APE12-dist-in 8.6225 APE11-dist-in 11.2666 APE10-dist-in 5.6159 APE9-dist-in 3.4261 None SEP474 SEP474 XRAY 2.4 0.22 0.264 B 346.0 289.0 0 28 28 0 [[321, 572]] 1.0 5upk STE_PAK4_HUMAN STE 3.1e-88 301.5 5.0 257.0 253.0 457 458 459 461 463 350 366 370 437 439 438 440.0 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIEA O96013 49 590 591.0 ANP:1001 ATPlike Inactive DFGin 6.2776 14.0298 BLAminus -142.71, -177.86 63.75, 67.7 -92.97, 13.53 295.29, 98.36 -64.15, -7.0 in-out in 6.9911 Saltbr-out 3.9737 HRD-in -74.78, -36.69 67.65, -13.13 out-in-out SNCoio in-out ActLoopNT-in 2.8563 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -135.98, 139.97 APE9-dihe-na 123.6, -177.34 APE8-dihe-in -84.44, 139.76 APE8-rot-out 19.51 APE67-dihe-in -74.38, -37.99 -51.24, -48.18 APE12-dist-in 9.5152 APE11-dist-in 11.685 APE10-dist-in 5.9086 APE9-dist-in 3.5078 None SEP474 SEP474 XRAY 3.11 0.257 0.276 A 423.0 301.0 0 28 28 0 [[321, 572]] 1.0 4fie STE_PAK4_HUMAN STE 5.6e-88 300.6 5.0 257.0 253.0 457 458 459 461 463 350 366 370 437 439 438 440.0 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIEB O96013 49 590 591.0 ANP:1001 ATPlike Inactive DFGin 6.2778 14.0307 BLAminus -142.24, -177.62 63.59, 67.55 -92.7, 13.49 295.33, 98.22 -64.04, -7.21 in-out in 6.9889 Saltbr-out 3.957 HRD-in -74.95, -36.21 66.97, -12.74 out-in-out SNCoio in-out ActLoopNT-in 2.8574 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.0, 139.86 APE9-dihe-na 123.6, -177.41 APE8-dihe-in -84.57, 139.76 APE8-rot-out 19.62 APE67-dihe-in -74.42, -37.89 -51.19, -48.15 APE12-dist-in 9.5148 APE11-dist-in 11.6892 APE10-dist-in 5.912 APE9-dist-in 3.5096 None SEP474 SEP474 XRAY 3.11 0.257 0.276 B 423.0 301.0 0 28 28 0 [[321, 572]] 1.0 4fie STE_PAK4_HUMAN STE 5.6e-88 300.6 5.0 257.0 253.0 457 458 459 461 463 350 366 370 437 439 438 440.0 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 7S46A O96013 300 589 591.0 ANP:600 ATPlike Active DFGin 9.0206 14.3488 BLAminus -133.61, -177.07 54.75, 76.68 -92.18, 14.46 286.49, 80.35 -59.04, -19.55 in-in in 7.5337 Saltbr-in 2.867 HRD-in -69.43, -50.5 76.76, 2.96 in-in-in SNCiii in-in ActLoopNT-in 2.9219 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.73, 132.58 APE9-dihe-na 145.82, -167.86 APE8-dihe-in -110.13, 128.57 APE8-rot-in 305.26 APE67-dihe-in -70.79, -21.11 -38.41, -55.32 APE12-dist-in 9.0199 APE11-dist-in 11.5375 APE10-dist-in 5.7927 APE9-dist-in 3.2862 D440N,S474E None None XRAY 2.1 0.182 0.22 A 346.0 290.0 0 28 28 0 [[321, 572]] 1.0 7s46 STE_PAK4_HUMAN STE 5.5e-87 297.4 5.0 257.0 253.0 457 458 459 461 463 350 366 370 437 439 438 440.0 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 7S47A O96013 300 589 591.0 ANP:600 ATPlike Active DFGin 9.2169 14.6465 BLAminus -126.8, -179.34 54.51, 73.91 -89.97, 15.41 285.81, 78.05 -59.21, -18.99 in-in in 7.7899 Saltbr-in 2.9309 HRD-in -66.64, -48.47 70.7, 6.89 in-in-in SNCiii in-in ActLoopNT-in 2.9139 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.53, 138.41 APE9-dihe-na 140.72, -164.27 APE8-dihe-in -114.61, 124.35 APE8-rot-in 304.9 APE67-dihe-in -66.22, -20.32 -36.39, -56.83 APE12-dist-in 9.0388 APE11-dist-in 11.4504 APE10-dist-in 5.7468 APE9-dist-in 3.4008 D440N,S474E None None XRAY 2.0 0.196 0.237 A 383.0 290.0 0 28 28 0 [[321, 572]] 1.0 7s47 STE_PAK4_HUMAN STE 7.5e-87 297.0 5.0 257.0 253.0 457 458 459 461 463 350 366 370 437 439 438 440.0 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIGB O96013 298 590 591.0 ANP:602 ATPlike Inactive DFGin 5.9786 13.8453 None -136.1, -40.27 -82.41, 70.29 -85.54, 12.48 305.29, 106.7 -66.77, -24.27 in-in in 7.0074 Saltbr-in 3.0472 HRD-in -63.37, -48.9 73.21, -4.05 in-in-in SNCiii in-in ActLoopNT-in 2.9294 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.8, 141.64 APE9-dihe-na 130.69, -165.45 APE8-dihe-in -110.43, 122.9 APE8-rot-in 324.7 APE67-dihe-in -77.33, -31.89 -29.23, -51.11 APE12-dist-in 9.7059 APE11-dist-in 11.7431 APE10-dist-in 5.9203 APE9-dist-in 3.3864 None SEP474 SEP474 XRAY 3.01 0.197 0.221 B 346.0 293.0 0 28 28 0 [[321, 572]] 1.0 4fig STE_PAK4_HUMAN STE 3.1e-88 301.5 5.0 257.0 253.0 457 458 459 461 463 350 366 370 437 439 438 440.0 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE STK24 STK24_HUMAN 4QMLA Q9Y6E0 30 310 443.0 ANP:60403 ATPlike Active DFGin 6.598 15.1775 BLAminus -130.38, 172.22 70.9, 79.24 -104.53, 20.01 285.96, 83.16 -61.35, -25.21 in-in in 9.0649 Saltbr-in 2.9268 HRD-in -70.82, -51.82 74.23, -2.97 in-in-in SNCiii in-in ActLoopNT-in 2.8482 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.04, 155.96 APE9-dihe-na 125.92, -168.67 APE8-dihe-in -115.63, 119.31 APE8-rot-in 310.36 APE67-dihe-in -60.1, -29.49 -47.33, -42.77 APE12-dist-in 8.2764 APE11-dist-in 11.0512 APE10-dist-in 5.5577 APE9-dist-in 3.3857 None TPO190 TPO190 XRAY 1.882 0.19 0.23 A 310.0 281.0 0 28 28 0 [[36, 286]] 1.0 4qml STE_STK24_HUMAN STE 3.9e-100 340.4 1.0 257.0 257.0 173 174 175 177 179 65 82 86 153 155 154 156.0 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK3 STK3_HUMAN 6AO5A Q13188 28 488 491.0 ANP:501 ATPlike Inactive DFGin 5.7624 13.2545 BLAplus -144.87, 157.4 64.61, 76.09 -109.93, -46.63 13.82, 108.09 -89.31, 27.29 out-out out 12.9083 Saltbr-out 12.1164 HRD-in -60.56, -48.36 76.32, -35.33 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nooo APE10-dihe-na -164.34, 157.95 APE9-dihe-na -118.75, -167.2 APE8-dihe-in -63.94, 121.38 APE8-rot-out 166.95 APE67-dihe-out -86.4, -39.81 -115.82, 59.17 APE12-dist-none 999.0 APE11-dist-out 17.8946 APE10-dist-out 16.1523 APE9-dist-out 11.0624 D146N None None XRAY 2.955 0.236 0.256 A 362.0 321.0 27 28 16 12 [[27, 278]] 1.0 6ao5 STE_STK3_HUMAN STE 3.6e-100 340.7 2.0 257.0 256.0 163 164 165 167 169 56 70 74 143 145 144 146.0 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 4LGDA Q13188 16 488 491.0 ANP:501 ATPlike Inactive DFGin 6.0177 17.0204 BLBminus -145.52, -179.3 43.95, 67.54 -70.27, 152.23 281.57, 44.13 -80.59, 163.91 out-out out 10.8887 Saltbr-out 5.7943 HRD-in -73.7, -41.12 68.58, 5.1 out-out-out SNCooo out-out ActLoopNT-out 8.7174 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -60.16, -34.45 APE9-dihe-na -67.84, -18.95 APE8-dihe-in -138.32, 78.16 APE8-rot-in 307.08 APE67-dihe-in -67.01, -21.51 -99.04, 14.35 APE12-dist-in 12.4566 APE11-dist-in 10.1948 APE10-dist-out 15.2694 APE9-dist-out 12.7523 D146N None None XRAY 3.05 0.202 0.244 A 378.0 350.0 0 28 28 0 [[27, 278]] 1.0 4lgd STE_STK3_HUMAN STE 4.1e-100 340.6 2.0 257.0 256.0 163 164 165 167 169 56 70 74 143 145 144 146.0 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 4LGDB Q13188 10 488 491.0 ANP:501 ATPlike Inactive DFGin 6.1597 16.6917 BLBminus -138.64, 169.86 44.76, 62.12 -62.36, 151.89 285.61, 26.54 -88.9, 160.74 out-out out 10.7358 Saltbr-out 6.0218 HRD-in -77.36, -41.29 64.17, 12.1 out-out-out SNCooo out-out ActLoopNT-out 9.006 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -74.54, -22.15 APE9-dihe-na -64.82, -19.37 APE8-dihe-in -144.49, 84.11 APE8-rot-in 305.11 APE67-dihe-in -63.85, -34.86 -100.76, 15.67 APE12-dist-in 12.5954 APE11-dist-in 10.2532 APE10-dist-out 15.0464 APE9-dist-out 12.7218 D146N None None XRAY 3.05 0.202 0.244 B 378.0 350.0 0 28 28 0 [[27, 278]] 1.0 4lgd STE_STK3_HUMAN STE 4.1e-100 340.6 2.0 257.0 256.0 163 164 165 167 169 56 70 74 143 145 144 146.0 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 4LGDC Q13188 12 490 491.0 ANP:501 ATPlike Inactive DFGin 6.3594 17.1177 BLBminus -149.78, 166.61 51.14, 65.46 -62.65, 153.33 284.02, 26.74 -77.49, 169.34 out-out out 10.5496 Saltbr-out 5.6105 HRD-in -72.97, -46.37 72.83, -1.88 out-out-out SNCooo out-out ActLoopNT-out 9.0368 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -57.36, -33.07 APE9-dihe-na -66.61, -18.79 APE8-dihe-in -138.0, 80.15 APE8-rot-in 301.29 APE67-dihe-in -70.28, -28.9 -100.7, 15.38 APE12-dist-in 12.4466 APE11-dist-in 10.0303 APE10-dist-out 15.1965 APE9-dist-out 12.6699 D146N None None XRAY 3.05 0.202 0.244 C 378.0 349.0 7 28 28 0 [[27, 278]] 1.0 4lgd STE_STK3_HUMAN STE 4.1e-100 340.6 2.0 257.0 256.0 163 164 165 167 169 56 70 74 143 145 144 146.0 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 4LGDD Q13188 11 489 491.0 ANP:501 ATPlike Inactive DFGin 6.2676 16.8909 BLBminus -143.39, 170.34 44.57, 62.98 -62.31, 161.36 279.47, 45.38 -101.43, 151.87 out-out out 10.7942 Saltbr-out 6.2875 HRD-in -67.38, -41.94 64.94, 10.19 out-out-out SNCooo out-out ActLoopNT-out 8.7906 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -65.98, -30.48 APE9-dihe-na -65.09, -18.33 APE8-dihe-in -145.24, 79.51 APE8-rot-in 304.52 APE67-dihe-in -64.33, -26.69 -98.63, 11.94 APE12-dist-in 12.4327 APE11-dist-in 10.3059 APE10-dist-out 15.3766 APE9-dist-out 12.7507 D146N None None XRAY 3.05 0.202 0.244 D 378.0 338.0 0 28 28 0 [[27, 278]] 1.0 4lgd STE_STK3_HUMAN STE 4.1e-100 340.6 2.0 257.0 256.0 163 164 165 167 169 56 70 74 143 145 144 146.0 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STE STRADA STRAA_HUMAN 2WTKB Q7RTN6 61 431 431.0 ANP:432 ATPlike Pseudo DFGin 5.1159 13.443 BLAminus -117.01, -150.73 71.3, 24.64 -54.34, -28.38 297.58, 14.45 -57.14, -26.88 out-none out 10.0156 Saltbr-none 999.0 HRD-in -75.87, -56.89 78.73, -4.32 none-in-out SNCnio in-out ActLoopNT-in 2.9208 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_iooo APE10-dihe-na -50.59, -53.43 APE9-dihe-na -67.53, -3.25 APE8-dihe-out -106.64, -20.66 APE8-rot-na 143.84 APE67-dihe-in -56.31, -21.98 -28.24, -53.75 APE12-dist-in 8.271 APE11-dist-out 7.4561 APE10-dist-out 12.8431 APE9-dist-out 9.3713 None None None XRAY 2.65 0.24 0.291 B 373.0 311.0 52 35 35 0 [[69, 379]] 1.0 2wtk STE_STRADA_HUMAN STE 4e-87 298.0 1.0 257.0 257.0 212 213 214 216 218 100 118 122 192 194 193 195.0 261 247 242 241 240 239 238 237 236 148 STE20-related kinase adapter protein alpha
STE STRADA STRAA_HUMAN 2WTKE Q7RTN6 60 431 431.0 ANP:432 ATPlike Pseudo DFGin 5.0759 13.5912 BLAminus -114.47, -147.76 66.21, 35.38 -66.23, -19.97 288.54, 169.08 -50.33, -33.69 in-none in 9.934 Saltbr-none 999.0 HRD-in -67.35, -61.05 78.73, -1.12 none-in-out SNCnio in-out ActLoopNT-in 2.861 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_iooo APE10-dihe-na -48.76, -50.43 APE9-dihe-na -62.69, -41.12 APE8-dihe-out -68.21, -28.45 APE8-rot-na 167.78 APE67-dihe-in -49.8, -37.77 -23.43, -57.21 APE12-dist-in 8.1186 APE11-dist-out 7.6425 APE10-dist-out 12.951 APE9-dist-out 9.4176 None None None XRAY 2.65 0.24 0.291 E 373.0 308.0 52 35 35 0 [[69, 379]] 1.0 2wtk STE_STRADA_HUMAN STE 4e-87 298.0 1.0 257.0 257.0 212 213 214 216 218 100 118 122 192 194 193 195.0 261 247 242 241 240 239 238 237 236 148 STE20-related kinase adapter protein alpha
STE TNIK TNIK_HUMAN 7XZRB Q9UKE5 12 312 1360.0 ANP:1401 ATPlike Active DFGin 6.4394 15.1629 BLAminus -131.61, 176.54 70.33, 83.31 -101.27, 21.61 286.01, 77.74 -67.8, -30.96 in-in in 9.1256 Saltbr-in 2.5815 HRD-in -64.36, -58.64 76.74, 3.35 in-in-in SNCiii in-in ActLoopNT-in 2.9312 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.27, 150.43 APE9-dihe-na 126.35, -168.16 APE8-dihe-in -105.07, 123.33 APE8-rot-in 308.43 APE67-dihe-in -61.4, -25.19 -44.62, -54.45 APE12-dist-in 8.7003 APE11-dist-in 11.7054 APE10-dist-in 6.0779 APE9-dist-in 3.7049 None TPO181,TPO187 TPO181,TPO187 XRAY 2.26 0.184 0.226 B 306.0 301.0 0 28 28 0 [[25, 289]] 1.0 7xzr STE_TNIK_HUMAN STE 3e-105 357.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 7XZRA Q9UKE5 12 310 1360.0 ANP:1401 Type1.5_Front Active DFGin 6.2745 14.1933 BLAminus -134.39, 177.59 74.52, 87.23 -110.98, 20.38 291.6, 89.06 -61.78, -40.23 in-in in 8.5907 Saltbr-in 2.8438 HRD-in -69.77, -51.11 71.86, 1.74 in-in-in SNCiii in-in ActLoopNT-in 2.9118 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.22, 154.28 APE9-dihe-na 131.69, -173.17 APE8-dihe-in -101.89, 120.07 APE8-rot-in 317.88 APE67-dihe-in -57.93, -30.58 -42.35, -51.61 APE12-dist-in 8.5949 APE11-dist-in 12.0463 APE10-dist-in 6.4403 APE9-dist-in 4.3071 None TPO181,TPO187 TPO181,TPO187 XRAY 2.26 0.184 0.226 A 306.0 299.0 0 28 28 0 [[25, 289]] 1.0 7xzr STE_TNIK_HUMAN STE 3e-105 357.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TKL ACVR1 ACVR1_HUMAN 6UNQA Q04771 206 496 509.0 ANP:501 ATPlike Inactive DFGin 7.4202 13.3371 BLAminus -125.65, 175.43 76.87, 82.94 -97.73, 22.73 293.77, 158.03 -74.66, -11.32 in-out in 8.4086 Saltbr-out 4.371 HRD-in -82.52, -56.03 82.09, -4.01 out-in-out SNCoio in-out ActLoopNT-in 2.8141 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.89, 171.23 APE9-dihe-na -69.6, 161.61 APE8-dihe-in -54.69, 120.18 APE8-rot-in 304.53 APE67-dihe-in -58.55, -27.57 -58.47, -38.91 APE12-dist-in 10.4635 APE11-dist-out 6.6677 APE10-dist-out 9.0755 APE9-dist-in 3.9229 K493A None None XRAY 2.4 0.221 0.283 A 330.0 289.0 3 32 32 0 [[207, 497]] 1.0 6unq TKL_ACVR1_HUMAN TKL 5e-85 291.3 2.0 266.0 265.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 6UNRA Q04771 208 496 509.0 ANP:501 ATPlike Inactive DFGin 7.2924 13.3423 BLAminus -137.01, 173.22 63.77, 86.25 -97.63, 26.62 300.72, 163.44 -66.11, -21.39 in-out in 8.4001 Saltbr-out 4.7436 HRD-in -74.93, -61.2 87.34, -7.73 out-in-out SNCoio in-out ActLoopNT-in 2.8371 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -115.39, 160.07 APE9-dihe-na -63.13, 170.03 APE8-dihe-in -59.34, 121.87 APE8-rot-in 302.11 APE67-dihe-in -65.55, -35.42 -57.38, -33.57 APE12-dist-in 10.4511 APE11-dist-out 6.8385 APE10-dist-out 9.1104 APE9-dist-in 3.9303 None None None XRAY 2.2 0.246 0.302 A 330.0 286.0 4 32 32 0 [[207, 497]] 1.0 6unr TKL_ACVR1_HUMAN TKL 7.3e-85 290.8 2.0 266.0 265.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ARAF ARAF_HUMAN 9AXMB P10398 302 574 606.0 ANP:60602 ATPlike Inactive DFGin 4.5967 13.3268 BLBplus -134.26, 172.61 61.7, 46.72 -103.54, 150.88 54.31, 89.4 54.71, 36.64 out-out out 11.556 Saltbr-out 10.4941 HRD-in -66.55, -46.59 76.65, -12.19 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -153.94 APE8-dihe-in -77.25, 142.54 APE8-rot-out 182.59 APE67-dihe-in -67.09, -22.55 -72.82, -26.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.5235 Y301D,Y302D None None XRAY 2.42 0.263 0.301 B 280.0 254.0 19 30 13 17 [[310, 569]] 1.0 9axm TKL_ARAF_HUMAN TKL 1.1e-77 267.1 2.0 266.0 265.0 446 447 448 450 452 336 354 358 426 428 427 429.0 491 476 471 470 469 468 467 466 465 383 Serine/threonine-protein kinase A-Raf
TKL BRAF BRAF_HUMAN 9AXXB P15056 449 721 766.0 ANP:60801 ATPlike Inactive DFGin 6.2724 14.156 BLAminus -118.96, -160.68 44.13, 79.21 -91.3, 29.71 285.28, 70.2 -64.85, -24.03 in-out in 8.9679 Saltbr-out 6.0423 HRD-in -74.42, -44.59 66.93, 5.21 out-in-in SNCoii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.1, 120.32 APE9-dihe-na 137.74, -165.97 APE8-dihe-in -102.01, 122.38 APE8-rot-in 304.65 APE67-dihe-in -63.13, -30.61 -66.04, -26.1 APE12-dist-in 13.0987 APE11-dist-in 12.6277 APE10-dist-in 7.4721 APE9-dist-in 5.708 None None None XRAY 2.07 0.215 0.248 B 280.0 261.0 12 30 24 6 [[457, 716]] 1.0 9axx TKL_BRAF_HUMAN TKL 7.8e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 9AXYA P15056 448 722 766.0 ANP:801 ATPlike Inactive DFGin 5.9166 13.5406 BLBplus -133.51, 174.13 59.27, 33.71 -86.77, 154.56 49.71, 87.92 69.37, -142.48 out-out out 14.0958 Saltbr-out 13.0065 HRD-in -70.93, -41.64 75.57, -39.02 out-out-out SNCooo out-out ActLoopNT-out 9.0693 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -141.06, 145.96 APE9-dihe-na 71.75, -130.61 APE8-dihe-in -87.56, 149.58 APE8-rot-out 200.58 APE67-dihe-in -69.57, -29.74 -96.77, -9.15 APE12-dist-out 14.1942 APE11-dist-out 15.515 APE10-dist-out 11.6629 APE9-dist-out 9.6767 None None None XRAY 3.6 0.19 0.237 A 280.0 275.0 0 30 30 0 [[457, 716]] 1.0 9axy TKL_BRAF_HUMAN TKL 7.8e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 6PP9A P15056 447 722 766.0 ANP:801 ATPlike Inactive DFGin 5.3423 13.4984 BLBplus -130.79, 177.54 57.37, 43.96 -96.57, 156.54 49.86, 89.0 63.47, -135.71 out-out out 14.313 Saltbr-out 12.6898 HRD-in -66.97, -47.8 65.51, 3.6 out-out-out SNCooo out-out ActLoopNT-out 9.2557 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -142.44, 146.23 APE9-dihe-na 73.26, -154.57 APE8-dihe-in -71.36, 154.2 APE8-rot-out 182.15 APE67-dihe-in -61.64, -19.53 -112.25, -5.75 APE12-dist-out 15.2013 APE11-dist-out 15.9004 APE10-dist-out 12.6934 APE9-dist-out 10.139 None None None XRAY 2.59 0.222 0.245 A 283.0 276.0 0 30 30 0 [[457, 716]] 1.0 6pp9 TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 6V2WA P15056 447 721 766.0 ANP:801 ATPlike Inactive DFGin 5.532 13.7036 BLBplus -135.72, 175.83 57.63, 35.46 -91.96, 158.82 53.8, 96.09 64.15, -137.39 out-out out 14.4746 Saltbr-out 12.4333 HRD-in -69.37, -44.53 66.04, 8.13 out-out-out SNCooo out-out ActLoopNT-out 8.9897 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -146.39, 170.31 APE9-dihe-na 111.41, -172.95 APE8-dihe-in -92.84, 135.37 APE8-rot-out 52.69 APE67-dihe-in -65.1, -26.74 -72.43, -22.76 APE12-dist-out 14.7285 APE11-dist-out 14.8979 APE10-dist-out 12.1593 APE9-dist-out 6.2561 None None None XRAY 3.12 0.189 0.237 A 283.0 275.0 0 30 30 0 [[457, 716]] 1.0 6v2w TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0TA P15056 448 721 766.0 ANP:801 ATPlike Inactive DFGin 5.4827 13.6452 BLBplus -101.53, -171.54 49.12, 40.35 -93.39, 158.36 49.68, 91.24 67.74, -141.33 out-out out 14.6334 Saltbr-out 13.4177 HRD-in -63.36, -50.98 81.19, -14.99 out-out-out SNCooo out-out ActLoopNT-out 9.0962 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iooo APE10-dihe-na -146.63, 169.35 APE9-dihe-na 113.78, -178.56 APE8-dihe-in -87.12, 141.18 APE8-rot-out 208.64 APE67-dihe-out -59.38, 160.81 -70.93, -34.96 APE12-dist-in 13.663 APE11-dist-out 15.2769 APE10-dist-out 12.4492 APE9-dist-out 6.6885 None None None XRAY 3.19 0.199 0.254 A 283.0 274.0 0 30 30 0 [[457, 716]] 1.0 7m0t TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0UA P15056 449 722 766.0 ANP:801 ATPlike Inactive DFGin 5.8262 13.5453 BLBplus -114.76, -174.76 53.19, 33.71 -86.73, 158.23 49.19, 93.22 61.58, -136.88 out-out out 14.5076 Saltbr-out 13.6281 HRD-in -66.62, -51.93 79.28, -5.3 out-out-out SNCooo out-out ActLoopNT-out 8.9683 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -137.94, 171.17 APE9-dihe-na 125.59, 173.92 APE8-dihe-in -78.53, 136.46 APE8-rot-out 49.62 APE67-dihe-in -63.36, -26.84 -75.55, -22.51 APE12-dist-out 14.5901 APE11-dist-out 14.4763 APE10-dist-out 12.1021 APE9-dist-out 6.3314 None None None XRAY 3.09 0.193 0.23 A 283.0 274.0 0 30 30 0 [[457, 716]] 1.0 7m0u TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0VA P15056 449 722 766.0 ANP:801 ATPlike Inactive DFGin 5.7413 13.2905 BLBplus -118.84, -178.01 61.17, 44.22 -99.98, 160.93 40.29, 99.45 62.33, -140.62 out-out out 14.1107 Saltbr-out 13.1408 HRD-in -76.68, -47.66 79.51, -34.29 out-out-out SNCooo out-out ActLoopNT-out 9.3238 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -140.71, 145.59 APE9-dihe-na 81.77, -131.39 APE8-dihe-in -106.29, 148.31 APE8-rot-out 201.4 APE67-dihe-in -54.29, -30.39 -107.29, -13.89 APE12-dist-in 13.9087 APE11-dist-out 15.7766 APE10-dist-out 12.613 APE9-dist-out 10.1626 None None None XRAY 3.16 0.188 0.234 A 283.0 274.0 0 30 30 0 [[457, 716]] 1.0 7m0v TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0WA P15056 448 721 766.0 ANP:801 ATPlike Inactive DFGin 5.6996 13.563 BLBplus -128.57, -174.24 58.52, 36.11 -93.32, 163.98 47.26, 91.72 57.0, -141.37 out-out out 14.2729 Saltbr-out 13.0439 HRD-in -64.47, -50.11 78.2, -6.17 out-out-out SNCooo out-out ActLoopNT-out 8.9804 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -140.16, 158.71 APE9-dihe-na 121.26, -178.69 APE8-dihe-in -87.94, 138.93 APE8-rot-out 43.99 APE67-dihe-in -65.6, -30.89 -79.08, -13.62 APE12-dist-out 14.335 APE11-dist-out 15.3422 APE10-dist-out 12.1341 APE9-dist-out 6.6508 None None None XRAY 3.09 0.197 0.233 A 283.0 274.0 0 30 30 0 [[457, 716]] 1.0 7m0w TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0XA P15056 447 722 766.0 ANP:801 ATPlike Inactive DFGin 5.4453 13.4953 BLBplus -123.82, 174.92 60.79, 42.33 -96.45, 161.16 49.04, 90.67 58.85, -140.33 out-out out 14.2652 Saltbr-out 13.0632 HRD-in -65.53, -50.34 78.03, -10.0 out-out-out SNCooo out-out ActLoopNT-out 9.2452 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -141.24, 149.26 APE9-dihe-na 65.43, -162.66 APE8-dihe-in -61.59, 142.77 APE8-rot-out 179.57 APE67-dihe-in -62.52, -26.23 -97.92, -3.07 APE12-dist-out 15.152 APE11-dist-out 15.9657 APE10-dist-out 12.6259 APE9-dist-out 10.0835 None None None XRAY 2.47 0.18 0.215 A 283.0 276.0 0 30 30 0 [[457, 716]] 1.0 7m0x TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0YA P15056 447 721 766.0 ANP:801 ATPlike Inactive DFGin 5.9246 13.72 BLBplus -130.12, 178.08 53.67, 39.87 -94.09, 143.26 51.07, 86.66 77.46, -140.33 out-out out 14.4541 Saltbr-out 12.4204 HRD-in -66.6, -53.86 81.89, -14.1 out-out-out SNCooo out-out ActLoopNT-out 8.9677 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -138.96, 162.77 APE9-dihe-na 110.62, -175.34 APE8-dihe-in -77.87, 138.5 APE8-rot-out 52.44 APE67-dihe-in -64.93, -32.89 -83.52, -17.07 APE12-dist-out 14.2255 APE11-dist-out 15.2702 APE10-dist-out 12.0065 APE9-dist-out 6.7809 None None None XRAY 3.45 0.196 0.218 A 283.0 275.0 0 30 30 0 [[457, 716]] 1.0 7m0y TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0ZA P15056 449 721 766.0 ANP:801 ATPlike Inactive DFGin 5.5912 13.5576 BLBplus -131.23, -177.35 57.24, 31.09 -88.02, 155.4 49.99, 89.35 66.37, -137.56 out-out out 14.3781 Saltbr-out 12.7969 HRD-in -63.1, -49.11 70.7, -2.29 out-out-out SNCooo out-out ActLoopNT-out 8.9341 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -140.88, 158.66 APE9-dihe-na 126.45, -167.01 APE8-dihe-in -93.79, 132.25 APE8-rot-out 208.38 APE67-dihe-in -66.35, -24.31 -75.16, -20.55 APE12-dist-in 12.9869 APE11-dist-out 14.9185 APE10-dist-out 11.8215 APE9-dist-out 6.3849 None None None XRAY 3.12 0.193 0.225 A 283.0 273.0 0 30 30 0 [[457, 716]] 1.0 7m0z TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 9ECUA P15056 447 722 766.0 ANP:801 ATPlike Inactive DFGin 5.3951 13.5556 BLBplus -125.65, 169.46 60.46, 40.01 -87.45, 154.95 47.27, 91.45 64.75, -132.56 out-out out 13.9748 Saltbr-out 13.7365 HRD-in -64.53, -58.29 87.19, -19.63 out-out-out SNCooo out-out ActLoopNT-out 9.2329 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -128.75, 123.72 APE9-dihe-na 163.56, -169.21 APE8-dihe-in -104.16, 118.8 APE8-rot-in 298.64 APE67-dihe-in -60.82, -35.98 -59.26, -34.28 APE12-dist-out 14.6908 APE11-dist-out 15.132 APE10-dist-out 11.51 APE9-dist-out 6.3102 None None None XRAY 3.46 0.202 0.237 A 284.0 276.0 0 30 30 0 [[457, 716]] 1.0 9ecu TKL_BRAF_HUMAN TKL 8.2e-82 280.6 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL IRAK4 IRAK4_HUMAN 2OIDA Q9NWZ3 164 458 460.0 ANP:1 ATPlike Inactive DFGin 6.9661 14.6844 BLAminus -127.55, 175.38 65.24, 82.27 -102.22, 23.11 306.08, 83.19 -64.75, -29.47 out-out out 11.8323 Saltbr-out 5.6903 HRD-in -73.12, -50.9 80.09, -6.55 out-in-in SNCoii in-in ActLoopNT-in 2.8231 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.88, 151.66 APE9-dihe-na 147.16, -164.5 APE8-dihe-in -113.74, 115.19 APE8-rot-in 308.34 APE67-dihe-in -64.44, -17.27 -37.39, -54.71 APE12-dist-in 9.8258 APE11-dist-in 11.5381 APE10-dist-in 6.0721 APE9-dist-in 3.8073 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.244 0.295 A 301.0 266.0 29 30 26 4 [[183, 456]] 1.0 2oid TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OIDB Q9NWZ3 164 459 460.0 ANP:2 ATPlike Inactive DFGin 6.94 14.7103 BLAminus -122.34, 171.98 72.6, 82.12 -104.43, 15.54 299.16, 90.11 -59.64, -29.05 in-out in 8.9076 Saltbr-out 3.9298 HRD-in -75.58, -47.6 78.52, -5.87 out-in-in SNCoii in-in ActLoopNT-in 2.7304 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.71, 158.05 APE9-dihe-na 142.8, -157.21 APE8-dihe-in -121.23, 117.8 APE8-rot-in 309.19 APE67-dihe-in -67.67, -11.87 -44.28, -49.35 APE12-dist-in 10.1904 APE11-dist-in 11.7427 APE10-dist-in 6.5221 APE9-dist-in 3.7233 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.244 0.295 B 301.0 274.0 22 30 24 6 [[183, 456]] 1.0 2oid TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OIDC Q9NWZ3 166 458 460.0 ANP:3 ATPlike Inactive DFGin 6.806 13.9727 BLAminus -130.4, 175.52 61.07, 75.53 -96.05, 32.37 309.84, 82.72 -74.67, -28.22 in-out in 8.9014 Saltbr-out 4.0238 HRD-in -62.6, -55.98 80.8, 1.53 out-in-in SNCoii in-in ActLoopNT-in 3.032 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.92, 158.28 APE9-dihe-na 138.01, -176.06 APE8-dihe-in -106.21, 116.22 APE8-rot-in 304.08 APE67-dihe-in -63.21, -15.57 -55.27, -41.4 APE12-dist-in 9.6871 APE11-dist-in 11.4204 APE10-dist-in 6.3612 APE9-dist-in 3.8779 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.244 0.295 C 301.0 259.0 34 30 24 6 [[183, 456]] 1.0 2oid TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OIDD Q9NWZ3 164 459 460.0 ANP:4 ATPlike Active DFGin 6.5602 13.9721 BLAminus -129.12, -177.03 59.13, 109.88 -131.38, 17.54 304.54, 87.5 -68.37, -4.63 in-in in 8.1503 Saltbr-in 3.5198 HRD-in -75.54, -51.34 70.58, 2.03 in-in-in SNCiii in-in ActLoopNT-in 2.7649 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.72, 147.52 APE9-dihe-na 139.0, -173.6 APE8-dihe-in -107.1, 118.58 APE8-rot-in 309.04 APE67-dihe-in -62.68, -15.82 -47.4, -49.91 APE12-dist-in 9.7501 APE11-dist-in 11.4404 APE10-dist-in 5.9279 APE9-dist-in 3.9698 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.244 0.295 D 301.0 277.0 19 30 27 3 [[183, 456]] 1.0 2oid TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6EGFB Q9NWZ3 164 460 460.0 ANP:501 ATPlike Inactive DFGin 5.6133 16.8833 BLBtrans -116.63, 167.73 64.0, 27.84 -68.07, 138.11 161.96, 71.15 80.16, -16.86 out-out out 13.6461 Saltbr-out 13.3901 HRD-in -72.08, -42.87 70.74, 1.24 out-out-out SNCooo out-out ActLoopNT-out 6.1127 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 31.47 APE8-rot-out 178.98 APE67-dihe-in -65.08, -16.47 -76.23, -17.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.61 0.206 0.229 B 302.0 285.0 12 30 18 12 [[183, 456]] 1.0 6egf TKL_IRAK4_HUMAN TKL 2.6e-83 285.5 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL KSR1 KSR1_HUMAN 9AXHC Q8IVT5 614 881 923.0 ANP:60901 ATPlike Pseudo DFGin 5.2299 13.2395 BLBplus -124.42, 164.81 64.66, 43.46 -90.48, 143.73 53.91, 91.43 61.22, 55.23 out-none out 14.31 Saltbr-none 999.0 HRD-in -67.1, -51.8 77.02, -11.89 none-out-out SNCnoo out-out ActLoopNT-out 7.6573 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -64.2, -39.05 APE9-dihe-na -59.17, -48.89 APE8-dihe-out -66.09, -38.64 APE8-rot-na 184.07 APE67-dihe-in -61.76, -22.42 -60.74, -36.73 APE12-dist-out 16.8898 APE11-dist-out 15.9594 APE10-dist-out 20.4992 APE9-dist-out 12.2193 None None None XRAY 2.81 0.206 0.253 C 283.0 259.0 10 33 26 7 [[613, 879]] 1.0 9axh TKL_KSR1_HUMAN TKL 2.1e-68 236.7 2.0 267.0 266.0 749 750 751 753 755 639 657 661 730 732 731 733.0 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 9AXHD Q8IVT5 613 881 923.0 ANP:60901 ATPlike Pseudo DFGin 5.2463 13.2292 BLBplus -126.56, 169.35 63.03, 47.69 -96.52, 141.09 54.28, 88.59 76.52, 29.36 out-none out 14.4881 Saltbr-none 999.0 HRD-in -67.9, -47.78 73.32, -2.62 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -60.7, -40.23 APE9-dihe-na -60.83, -42.14 APE8-dihe-out -70.49, -38.33 APE8-rot-na 183.99 APE67-dihe-in -64.38, -16.08 -60.51, -36.42 APE12-dist-out 17.0875 APE11-dist-out 16.2284 APE10-dist-out 20.7005 APE9-dist-out 12.5971 None None None XRAY 2.81 0.206 0.253 D 283.0 249.0 20 33 20 13 [[613, 879]] 1.0 9axh TKL_KSR1_HUMAN TKL 2.1e-68 236.7 2.0 267.0 266.0 749 750 751 753 755 639 657 661 730 732 731 733.0 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JUWB Q8IVT5 601 881 923.0 ANP:901 ATPlike Pseudo DFGin 5.4788 13.4359 BLBplus -116.78, 175.7 58.02, 37.9 -91.13, 161.87 61.57, 85.28 62.4, -8.11 out-none out 13.3396 Saltbr-none 999.0 HRD-in -64.36, -50.52 68.6, 3.9 none-out-out SNCnoo out-out ActLoopNT-out 7.1258 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -75.12, -46.44 APE9-dihe-na -49.25, -41.63 APE8-dihe-out -65.16, -50.29 APE8-rot-na 182.96 APE67-dihe-in -55.58, -30.38 -61.8, -31.6 APE12-dist-out 17.6819 APE11-dist-out 16.5985 APE10-dist-out 21.0265 APE9-dist-out 12.8341 None None None XRAY 2.88 0.245 0.286 B 334.0 277.0 4 33 29 4 [[613, 879]] 1.0 7juw TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2.0 267.0 266.0 749 750 751 753 755 639 657 661 730 732 731 733.0 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JUXA Q8IVT5 600 881 923.0 ANP:901 ATPlike Pseudo DFGin 5.3021 12.8866 BLBplus -130.76, 153.55 60.79, 41.41 -77.85, 152.64 59.13, 80.46 58.16, 12.6 out-none out 13.5859 Saltbr-none 999.0 HRD-out -82.48, 84.18 -62.97, 148.26 none-out-out SNCnoo out-out ActLoopNT-out 7.0623 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -85.2, -42.07 APE9-dihe-na -55.8, -29.41 APE8-dihe-out -77.82, -37.67 APE8-rot-na 188.53 APE67-dihe-in -61.89, -19.45 -62.94, -36.24 APE12-dist-out 17.4266 APE11-dist-out 16.2348 APE10-dist-out 20.6238 APE9-dist-out 14.0574 None None None XRAY 3.34 0.265 0.283 A 334.0 278.0 4 33 29 4 [[613, 879]] 1.0 7jux TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2.0 267.0 266.0 749 750 751 753 755 639 657 661 730 732 731 733.0 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JUYB Q8IVT5 601 881 923.0 ANP:901 ATPlike Pseudo DFGin 5.6126 13.191 BLBplus -117.18, 175.18 57.71, 38.02 -91.22, 161.18 61.47, 85.63 62.09, -7.96 out-none out 13.3948 Saltbr-none 999.0 HRD-in -64.77, -50.93 68.2, 3.89 none-out-out SNCnoo out-out ActLoopNT-out 7.0671 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -74.87, -46.12 APE9-dihe-na -49.26, -41.38 APE8-dihe-out -64.88, -49.41 APE8-rot-na 183.95 APE67-dihe-in -56.03, -30.73 -61.35, -31.75 APE12-dist-out 17.5559 APE11-dist-out 16.5246 APE10-dist-out 20.9468 APE9-dist-out 12.7704 None None None XRAY 3.096 0.248 0.257 B 334.0 276.0 5 33 28 5 [[613, 879]] 1.0 7juy TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2.0 267.0 266.0 749 750 751 753 755 639 657 661 730 732 731 733.0 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JUZA Q8IVT5 601 881 923.0 ANP:901 ATPlike Pseudo DFGin 5.2511 13.1443 BLBplus -120.58, 157.85 65.97, 36.71 -81.68, 149.84 60.82, 87.44 61.36, 0.32 out-none out 13.842 Saltbr-none 999.0 HRD-in -63.05, -49.06 69.65, 1.96 none-out-out SNCnoo out-out ActLoopNT-out 6.9627 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -71.77, -43.35 APE9-dihe-na -54.66, -39.8 APE8-dihe-out -69.49, -39.39 APE8-rot-na 184.11 APE67-dihe-in -64.95, -32.88 -59.75, -32.59 APE12-dist-out 17.5733 APE11-dist-out 16.4181 APE10-dist-out 20.8305 APE9-dist-out 12.5923 None None None XRAY 3.21 0.255 0.272 A 334.0 273.0 8 33 25 8 [[613, 879]] 1.0 7juz TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2.0 267.0 266.0 749 750 751 753 755 639 657 661 730 732 731 733.0 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JV0A Q8IVT5 601 881 923.0 ANP:901 ATPlike Pseudo DFGin 5.5443 13.2313 BLBplus -113.37, 179.62 53.84, 36.37 -87.67, 157.34 63.1, 86.33 73.66, -16.65 out-none out 13.3345 Saltbr-none 999.0 HRD-in -63.7, -53.29 73.57, 2.92 none-out-out SNCnoo out-out ActLoopNT-out 7.0046 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -74.36, -44.01 APE9-dihe-na -53.64, -41.33 APE8-dihe-out -66.6, -51.73 APE8-rot-na 184.61 APE67-dihe-in -59.37, -29.99 -47.75, -40.44 APE12-dist-out 17.6316 APE11-dist-out 16.6587 APE10-dist-out 21.0828 APE9-dist-out 12.7813 None None None XRAY 3.63 0.247 0.26 A 334.0 276.0 5 33 28 5 [[613, 879]] 1.0 7jv0 TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2.0 267.0 266.0 749 750 751 753 755 639 657 661 730 732 731 733.0 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JV1D Q8IVT5 600 881 923.0 ANP:901 ATPlike Pseudo DFGin 4.998 13.0281 BLBplus -130.92, 154.93 60.0, 40.35 -76.18, 155.67 58.85, 79.94 54.95, 12.06 out-none out 13.7859 Saltbr-none 999.0 HRD-out -81.07, 84.18 -62.62, 147.5 none-out-out SNCnoo out-out ActLoopNT-out 6.8084 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -83.95, -45.7 APE9-dihe-na -55.75, -29.37 APE8-dihe-out -76.69, -37.65 APE8-rot-na 188.09 APE67-dihe-in -60.65, -19.03 -62.72, -36.82 APE12-dist-out 17.4871 APE11-dist-out 16.3482 APE10-dist-out 20.8077 APE9-dist-out 14.1451 None None None XRAY 3.62 0.278 0.303 D 334.0 275.0 7 33 26 7 [[613, 879]] 1.0 7jv1 TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2.0 267.0 266.0 749 750 751 753 755 639 657 661 730 732 731 733.0 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR2 KSR2_HUMAN 7JURB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.5336 13.4444 BLBplus -136.74, 172.29 64.43, 21.01 -64.29, 145.08 51.43, 88.21 72.32, -17.93 out-none out 13.0577 Saltbr-none 999.0 HRD-in -74.46, -55.37 71.55, 3.38 none-out-out SNCnoo out-out ActLoopNT-out 7.6074 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -61.97, 131.45 APE9-dihe-na 84.3, -3.37 APE8-dihe-out -70.0, -57.71 APE8-rot-na 184.79 APE67-dihe-in -71.0, 1.52 -53.02, -42.72 APE12-dist-out 18.4829 APE11-dist-out 15.1355 APE10-dist-out 19.7424 APE9-dist-out 12.323 None None None XRAY 2.82 0.237 0.277 B 342.0 277.0 4 33 30 3 [[665, 930]] 1.0 7jur TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2.0 267.0 266.0 802 803 804 806 808 692 710 714 783 785 784 786.0 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JUSB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.883 13.3826 BLBplus -127.91, 171.08 62.77, 22.74 -63.47, 150.27 47.2, 86.11 68.89, -21.25 out-none out 13.5127 Saltbr-none 999.0 HRD-in -73.66, -56.88 73.44, -2.22 none-out-out SNCnoo out-out ActLoopNT-out 7.5085 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -57.38, 137.79 APE9-dihe-na 90.37, -24.33 APE8-dihe-out -66.74, -57.02 APE8-rot-na 187.61 APE67-dihe-in -75.11, -1.38 -58.95, -34.29 APE12-dist-out 18.4212 APE11-dist-out 15.0772 APE10-dist-out 19.629 APE9-dist-out 12.0355 None None None XRAY 2.99 0.249 0.265 B 342.0 276.0 5 33 29 4 [[665, 930]] 1.0 7jus TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2.0 267.0 266.0 802 803 804 806 808 692 710 714 783 785 784 786.0 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JUTB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.5556 12.9608 BLBplus -137.17, 153.82 70.92, 32.74 -74.86, 135.77 48.5, 88.18 74.13, -4.82 out-none out 14.2086 Saltbr-none 999.0 HRD-in -85.35, -39.03 46.26, 13.05 none-out-out SNCnoo out-out ActLoopNT-out 7.1963 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -53.57, -55.36 APE9-dihe-na -91.09, 3.18 APE8-dihe-out -71.8, -46.41 APE8-rot-na 181.21 APE67-dihe-in -68.18, -7.53 -62.86, -41.09 APE12-dist-out 18.1273 APE11-dist-out 15.4306 APE10-dist-out 19.5584 APE9-dist-out 11.9249 None None None XRAY 3.09 0.259 0.3 B 342.0 277.0 4 33 30 3 [[665, 930]] 1.0 7jut TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2.0 267.0 266.0 802 803 804 806 808 692 710 714 783 785 784 786.0 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JUUB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.7734 13.2212 BLBplus -133.64, 151.36 70.73, 33.64 -75.25, 133.98 46.29, 83.15 80.08, -8.46 out-none out 14.4329 Saltbr-none 999.0 HRD-in -73.56, -47.69 67.59, 2.06 none-out-out SNCnoo out-out ActLoopNT-out 7.385 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -58.47, -51.54 APE9-dihe-na -86.76, 0.87 APE8-dihe-out -74.62, -44.43 APE8-rot-na 183.38 APE67-dihe-in -73.96, -6.37 -64.52, -36.97 APE12-dist-out 18.347 APE11-dist-out 15.5896 APE10-dist-out 19.7935 APE9-dist-out 12.0932 None None None XRAY 3.19 0.242 0.258 B 342.0 277.0 4 33 30 3 [[665, 930]] 1.0 7juu TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2.0 267.0 266.0 802 803 804 806 808 692 710 714 783 785 784 786.0 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JUVB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.981 13.017 BLBplus -127.69, 170.94 63.29, 22.28 -64.16, 148.8 47.81, 86.58 68.48, -22.21 out-none out 13.6049 Saltbr-none 999.0 HRD-in -73.05, -56.86 73.65, -2.34 none-out-out SNCnoo out-out ActLoopNT-out 7.5025 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -57.84, 138.27 APE9-dihe-na 90.88, -24.23 APE8-dihe-out -67.14, -55.82 APE8-rot-na 188.73 APE67-dihe-in -75.46, -2.03 -58.92, -34.4 APE12-dist-out 18.2958 APE11-dist-out 15.1752 APE10-dist-out 19.8349 APE9-dist-out 12.1991 None None None XRAY 3.36 0.242 0.255 B 342.0 277.0 4 33 30 3 [[665, 930]] 1.0 7juv TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2.0 267.0 266.0 802 803 804 806 808 692 710 714 783 785 784 786.0 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7UMBB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.5115 13.3329 BLBplus -122.69, -178.17 55.62, 31.28 -75.96, 141.02 47.41, 88.89 74.01, -10.38 out-none out 13.0769 Saltbr-none 999.0 HRD-in -83.2, -50.32 69.21, 5.46 none-out-out SNCnoo out-out ActLoopNT-out 7.5301 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -52.68, 124.31 APE9-dihe-na 106.73, -20.32 APE8-dihe-out -71.55, -49.08 APE8-rot-na 185.38 APE67-dihe-in -79.33, 2.43 -65.58, -32.18 APE12-dist-out 18.1185 APE11-dist-out 15.3981 APE10-dist-out 19.7231 APE9-dist-out 12.0091 None None None XRAY 3.231 0.231 0.268 B 342.0 277.0 4 33 30 3 [[665, 930]] 1.0 7umb TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2.0 267.0 266.0 802 803 804 806 808 692 710 714 783 785 784 786.0 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL LIMK1 LIMK1_HUMAN 5HVJA P53667 329 633 647.0 ANP:1000 ATPlike Inactive DFGin 6.1667 14.0183 BLAminus -132.74, -177.4 60.53, 87.07 -109.1, 23.76 308.69, 90.48 -66.78, -25.98 in-in in 8.1192 Saltbr-in 2.7865 HRD-in -65.97, -50.93 68.53, 0.88 in-in-out SNCiio in-out ActLoopNT-in 2.9434 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oiio APE10-dihe-na -124.58, 95.6 APE9-dihe-na 76.06, -115.03 APE8-dihe-in -111.26, 122.06 APE8-rot-na 224.18 APE67-dihe-in -69.88, -30.27 -73.34, -10.37 APE12-dist-out 14.7577 APE11-dist-in 11.8135 APE10-dist-in 6.9252 APE9-dist-out 6.3724 D460N None None XRAY 2.2 0.208 0.252 A 315.0 283.0 22 42 20 22 [[339, 606]] 1.0 5hvj TKL_LIMK1_HUMAN TKL 3e-76 262.4 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL LIMK1 LIMK1_HUMAN 5HVKA P53667 329 634 647.0 ANP:61001 ATPlike Active DFGin 6.4055 13.6462 BLAminus -145.46, 176.84 65.07, 82.49 -109.26, 24.73 304.62, 92.73 -71.79, -22.73 in-in in 7.7955 Saltbr-in 3.1595 HRD-in -70.8, -44.42 59.42, 18.52 in-in-in SNCiii in-in ActLoopNT-in 3.3239 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -139.63, 151.17 APE9-dihe-na 143.88, 171.7 APE8-dihe-in -71.51, 120.27 APE8-rot-na 199.31 APE67-dihe-in -66.59, -36.22 -54.03, -34.34 APE12-dist-in 9.3008 APE11-dist-in 11.0813 APE10-dist-in 5.6355 APE9-dist-in 3.574 D460N TPO508 TPO508 XRAY 3.5 0.275 0.31 A 315.0 293.0 13 42 29 13 [[339, 606]] 1.0 5hvk TKL_LIMK1_HUMAN TKL 3e-76 262.4 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL LIMK1 LIMK1_HUMAN 5HVKC P53667 329 633 647.0 ANP:60701 ATPlike Inactive DFGin 6.0783 13.9339 None -149.69, 172.69 -101.87, 169.41 -110.21, 23.25 306.34, 92.8 -73.91, -25.16 in-out in 7.8911 Saltbr-out 3.6442 HRD-in -72.39, -44.63 59.79, 17.6 out-in-in SNCoii in-in ActLoopNT-in 3.0698 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -140.53, 148.22 APE9-dihe-na 140.89, 172.08 APE8-dihe-in -72.12, 119.75 APE8-rot-na 199.66 APE67-dihe-in -64.48, -35.33 -54.5, -33.22 APE12-dist-in 8.6689 APE11-dist-in 11.1988 APE10-dist-in 5.8992 APE9-dist-in 3.5423 D460N TPO508 TPO508 XRAY 3.5 0.275 0.31 C 315.0 291.0 14 42 28 14 [[339, 606]] 1.0 5hvk TKL_LIMK1_HUMAN TKL 3e-76 262.4 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL LRRK2 LRRK2_HUMAN 8VH5A Q5S007 12 2527 2527.0 ANP:2602 ATPlike Inactive DFGinter 9.7464 8.455 None -88.01, 106.84 -81.35, 17.64 -78.83, -10.5 197.42, 64.93 -68.71, -22.79 out-out out 11.3256 Saltbr-out 8.1229 HRD-in -105.05, -49.61 72.56, -5.72 out-out-out SNCooo out-out ActLoopNT-out 8.9614 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -67.06, -23.38 APE9-dihe-na 73.72, 168.0 APE8-dihe-in -68.8, 143.98 APE8-rot-out 58.99 APE67-dihe-in -65.74, -54.3 -73.05, -29.17 APE12-dist-in 9.6328 APE11-dist-in 8.4163 APE10-dist-out 13.3438 APE9-dist-in 3.8609 None None None EM 4.0 999.0 999.0 A 2527.0 2221.0 8 26 18 8 [[1875, 2134]] 1.0 8vh5 TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8VH5C Q5S007 12 2527 2527.0 ANP:2602 ATPlike Inactive DFGinter 9.746 8.4552 None -88.01, 106.86 -81.36, 17.7 -78.84, -10.6 197.4, 64.92 -68.66, -22.76 out-out out 11.3253 Saltbr-out 8.1217 HRD-in -104.99, -49.63 72.52, -5.67 out-out-out SNCooo out-out ActLoopNT-out 8.9613 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -66.98, -23.42 APE9-dihe-na 73.64, 168.02 APE8-dihe-in -68.73, 143.93 APE8-rot-out 59.0 APE67-dihe-in -65.76, -54.24 -73.07, -29.13 APE12-dist-in 9.6328 APE11-dist-in 8.4176 APE10-dist-out 13.3446 APE9-dist-in 3.8618 None None None EM 4.0 999.0 999.0 C 2527.0 2221.0 8 26 18 8 [[1875, 2134]] 1.0 8vh5 TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8VH4A Q5S007 12 2527 2527.0 ANP:2602 ATPlike Inactive None 999.0 999.0 None -94.14, 87.28 -74.17, 5.0 -60.35, -20.37 999.0, 999.0 -59.12, -33.8 out-none out 12.056 Saltbr-none 999.0 HRD-in -102.88, -51.08 73.15, -5.33 none-out-out SNCnoo out-out ActLoopNT-out 8.7502 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -76.21, -33.07 APE9-dihe-na 74.7, 171.21 APE8-dihe-in -59.82, 149.42 APE8-rot-out 184.58 APE67-dihe-in -66.4, -59.35 -67.96, -43.48 APE12-dist-in 10.2221 APE11-dist-in 9.4484 APE10-dist-out 13.4907 APE9-dist-in 4.0567 None None None EM 4.1 999.0 999.0 A 2527.0 2235.0 8 26 18 8 [[1875, 2134]] 1.0 8vh4 TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL RAF1 RAF1_HUMAN 9AY7A P04049 343 612 648.0 ANP:701 ATPlike Inactive DFGin 5.8053 13.462 BLBplus -133.55, 174.37 58.47, 38.44 -90.49, 142.18 44.05, 90.72 78.29, -134.9 out-out out 14.0699 Saltbr-out 12.7376 HRD-in -73.02, -44.7 76.86, -25.12 out-out-out SNCooo out-out ActLoopNT-out 9.1822 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -145.48, 130.61 APE9-dihe-na 129.03, -169.57 APE8-dihe-in -79.63, 137.79 APE8-rot-in 302.79 APE67-dihe-in -63.4, -34.24 -69.33, -38.68 APE12-dist-out 15.2361 APE11-dist-out 15.0562 APE10-dist-out 10.6236 APE9-dist-out 6.3059 Y340D,Y341D None None XRAY 2.41 0.203 0.236 A 280.0 260.0 10 30 24 6 [[349, 608]] 1.0 9ay7 TKL_RAF1_HUMAN TKL 2.6e-81 279.0 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
TKL TGFBR2 TGFR2_HUMAN 5E92A P37173 240 543 567.0 ANP:601 ATPlike Active DFGin 7.3963 13.3025 BLAminus -134.93, 178.1 63.07, 87.04 -105.26, 16.76 300.78, 96.96 -60.58, -26.14 in-in in 7.67 Saltbr-in 2.7517 HRD-in -64.87, -46.8 71.14, -4.53 in-in-in SNCiii in-in ActLoopNT-in 2.9815 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.21, 144.17 APE9-dihe-na 126.96, -149.92 APE8-dihe-in -116.55, 119.38 APE8-rot-in 300.41 APE67-dihe-in -54.91, -33.03 -42.96, -45.47 APE12-dist-in 11.7882 APE11-dist-in 12.049 APE10-dist-in 6.0891 APE9-dist-in 3.4015 E431A,R433A,E485A,K488A,R493A,R495A None None XRAY 2.08 0.204 0.231 A 316.0 298.0 6 32 32 0 [[244, 540]] 1.0 5e92 TKL_TGFBR2_HUMAN TKL 1.9e-77 266.3 2.0 266.0 265.0 396 397 398 400 402 277 290 294 376 378 377 379.0 446 428 423 422 421 420 419 418 417 326 TGF-beta receptor type-2
TYR EGFR EGFR_HUMAN 3VJNA P00533 697 1018 1210.0 ANP:2001 ATPlike Inactive DFGin 6.0696 15.5531 BLAminus -140.47, -172.56 66.89, 81.42 -96.27, 22.36 285.26, 99.8 -61.68, -24.37 in-out in 8.8641 Saltbr-out 4.1594 HRD-in -62.92, -47.49 66.12, 0.14 out-in-in SNCoii in-in ActLoopNT-in 2.9023 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.98, 116.83 APE9-dihe-in -113.71, 140.82 APE8-dihe-in -56.67, 106.47 APE8-rot-na 28.1 APE67-dihe-in -67.09, -6.37 -61.28, -43.59 APE12-dist-na 11.7786 APE11-dist-na 9.7482 APE10-dist-na 10.9834 APE9-dist-in 5.9878 G719S,T790M None None XRAY 2.34 0.197 0.244 A 334.0 297.0 4 30 30 0 [[712, 970]] 1.0 3vjn TYR_EGFR_HUMAN TYR 7.9e-87 296.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8DSWA P00533 696 1017 1210.0 ANP:61104 ATPlike None DFGin 5.9264 15.8583 BLAminus -139.88, -174.48 62.3, 80.03 -97.39, 21.12 300.26, 86.52 -53.52, -37.16 none-none none 999.0 Saltbr-none 999.0 HRD-in -81.01, -46.59 69.43, -1.39 none-in-none SNCnin in-none ActLoopNT-in 2.9212 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 105.32 APE8-dihe-in -90.45, 95.73 APE8-rot-na 32.83 APE67-dihe-in -75.5, -1.32 -70.5, -35.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.2191 None None None XRAY 2.39 0.197 0.246 A 335.0 301.0 12 30 21 9 [[712, 970]] 1.0 8dsw TYR_EGFR_HUMAN TYR 1.9e-85 292.3 3.0 259.0 257.0 854 855 856 858 860 745 -9999 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITXA P00533 697 1019 1210.0 ANP:2020 ATPlike Active DFGin 5.8743 15.7373 BLAminus -136.31, -171.94 65.34, 93.22 -111.54, 18.75 298.27, 92.75 -59.44, 2.06 in-in in 9.2412 Saltbr-in 3.5833 HRD-in -62.41, -44.72 61.37, 7.79 in-in-in SNCiii in-in ActLoopNT-in 2.6419 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.73, 124.39 APE9-dihe-in -125.4, 144.12 APE8-dihe-in -79.64, 94.32 APE8-rot-na 30.37 APE67-dihe-in -65.37, -0.17 -61.69, -47.61 APE12-dist-na 11.888 APE11-dist-na 10.1512 APE10-dist-na 11.1341 APE9-dist-in 7.0583 None None None XRAY 2.98 0.191 0.261 A 327.0 307.0 4 30 26 4 [[712, 970]] 1.0 2itx TYR_EGFR_HUMAN TYR 1e-87 299.8 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3VJOA P00533 696 1018 1210.0 ANP:2001 ATPlike Inactive DFGin 6.0205 15.9464 BLAminus -140.25, -165.5 56.51, 77.02 -90.26, 19.04 285.97, 94.98 -60.96, -7.67 in-out in 9.402 Saltbr-out 4.5501 HRD-in -69.17, -43.62 63.06, 0.57 out-in-in SNCoii in-in ActLoopNT-in 2.9208 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.49, 106.7 APE9-dihe-in -122.63, 146.56 APE8-dihe-in -79.91, 93.84 APE8-rot-na 34.61 APE67-dihe-in -67.26, -9.93 -59.74, -34.59 APE12-dist-na 12.246 APE11-dist-na 10.097 APE10-dist-na 10.7621 APE9-dist-in 6.7711 None None None XRAY 2.64 0.19 0.228 A 334.0 298.0 5 30 30 0 [[712, 970]] 1.0 3vjo TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITNA P00533 696 1019 1210.0 ANP:2021 ATPlike None DFGin 6.2826 15.2349 BLAminus -127.19, -173.38 63.95, 79.84 -96.65, 10.56 295.4, 91.5 -73.87, 28.38 in-in in 8.2744 Saltbr-in 3.4075 HRD-in -81.37, -44.82 70.79, -0.2 in-in-none SNCiin in-none ActLoopNT-in 2.8429 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 98.73 APE8-dihe-in -79.18, 91.37 APE8-rot-na 30.4 APE67-dihe-in -69.96, -4.57 -72.15, -41.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6741 G719S None None XRAY 2.47 0.201 0.267 A 327.0 304.0 9 30 21 9 [[712, 970]] 1.0 2itn TYR_EGFR_HUMAN TYR 9.6e-87 296.6 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITVA P00533 696 1019 1210.0 ANP:2020 ATPlike None DFGin 6.2164 15.481 BLAminus -132.41, -173.63 61.69, 81.35 -94.21, 13.19 293.51, 90.37 -58.84, 7.8 in-in in 8.5836 Saltbr-in 3.4621 HRD-in -75.87, -46.5 68.4, 1.6 in-in-none SNCiin in-none ActLoopNT-in 2.7367 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.23 APE8-dihe-in -83.21, 92.63 APE8-rot-na 31.24 APE67-dihe-in -66.41, -6.91 -75.93, -39.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5693 L858R None None XRAY 2.47 0.197 0.242 A 327.0 303.0 9 30 21 9 [[712, 970]] 1.0 2itv TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2EB3A P00533 696 1018 1210.0 ANP:2001 ATPlike Inactive DFGin 4.6656 14.8692 BLAplus -146.31, -170.86 55.73, 31.55 -96.53, 44.19 45.64, 108.62 -72.56, -59.05 in-in in 8.5938 Saltbr-in 3.4427 HRD-out -53.85, 138.27 -123.62, 23.93 in-in-none SNCiin in-none ActLoopNT-in 2.5854 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 154.55 APE8-dihe-in -88.38, 74.74 APE8-rot-na 41.16 APE67-dihe-in -67.41, -11.07 -62.2, -31.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8933 None None None XRAY 2.84 0.19 0.236 A 334.0 294.0 15 30 16 14 [[712, 970]] 1.0 2eb3 TYR_EGFR_HUMAN TYR 1.2e-86 296.3 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1LB P00533 702 1008 1210.0 ANP:1102 ATPlike Inactive DFGin 4.3261 15.4771 BLBplus -134.87, 177.11 52.28, 41.66 -92.52, 151.37 118.41, 82.73 79.24, 7.39 out-out out 13.7513 Saltbr-out 14.7662 HRD-in -69.63, -50.82 67.27, 3.74 out-out-out SNCooo out-out ActLoopNT-out 8.6943 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -67.98 APE8-dihe-in -90.55, 79.54 APE8-rot-na 36.74 APE67-dihe-in -76.92, -3.19 -66.82, -38.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.3817 T790M,V948R None None XRAY 2.8 0.203 0.237 B 327.0 292.0 15 30 15 15 [[712, 970]] 1.0 6p1l TYR_EGFR_HUMAN TYR 6e-88 300.6 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6WAKA P00533 702 1013 1210.0 ANP:1101 ATPlike Inactive DFGin 3.6796 14.038 BLBplus -119.87, 174.58 64.54, 16.96 -69.25, 144.86 73.85, 86.13 77.2, -6.44 out-out out 14.1902 Saltbr-out 14.8704 HRD-in -68.06, -64.5 89.93, -15.8 out-out-out SNCooo out-out ActLoopNT-out 6.0562 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -95.75, -0.13 APE9-dihe-in -104.56, 101.78 APE8-dihe-in -62.85, 69.07 APE8-rot-na 27.65 APE67-dihe-in -73.63, -8.28 -54.79, -35.95 APE12-dist-na 999.0 APE11-dist-na 15.6242 APE10-dist-na 11.3401 APE9-dist-in 7.7723 T790M,V948R None None XRAY 2.4 0.219 0.23 A 328.0 297.0 10 30 20 10 [[712, 970]] 1.0 6wak TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6WAKD P00533 701 1014 1210.0 ANP:1101 ATPlike Inactive DFGin 3.8807 14.6672 BLBplus -128.56, 164.59 71.9, 35.94 -89.47, 146.64 77.53, 95.38 87.93, -24.37 out-out out 13.7529 Saltbr-out 11.845 HRD-in -75.5, -62.2 82.94, 0.35 out-out-out SNCooo out-out ActLoopNT-out 6.735 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.69 APE8-dihe-in -82.11, 67.25 APE8-rot-na 35.47 APE67-dihe-in -67.78, -4.44 -51.76, -45.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.0459 T790M,V948R None None XRAY 2.4 0.219 0.23 D 328.0 297.0 17 30 16 14 [[712, 970]] 1.0 6wak TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8FV3A P00533 701 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 3.9601 13.3971 BLBplus -132.16, 169.96 65.72, 32.0 -78.17, 140.3 56.84, 82.43 67.0, 6.27 out-out out 13.5436 Saltbr-out 14.7322 HRD-in -69.71, -62.71 86.1, -12.85 out-out-none SNCoon out-none ActLoopNT-out 6.5423 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 27.23 APE9-dihe-in -63.25, 122.03 APE8-dihe-in -75.98, 67.82 APE8-rot-na 29.66 APE67-dihe-in -76.37, -3.74 -56.38, -36.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.7262 APE9-dist-in 7.9867 T790M,V948R None None XRAY 2.1 0.191 0.226 A 328.0 299.0 14 30 18 12 [[712, 970]] 1.0 8fv3 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8FV4C P00533 702 1013 1210.0 ANP:1102 ATPlike Inactive DFGin 4.0815 13.5578 BLBplus -127.73, 168.23 73.07, 11.78 -61.24, 145.82 61.45, 98.91 81.41, -31.2 out-out out 13.7417 Saltbr-out 16.1154 HRD-in -67.13, -63.64 88.26, -13.01 out-out-out SNCooo out-out ActLoopNT-out 6.5839 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -45.21, -49.43 APE9-dihe-in -74.91, 126.99 APE8-dihe-in -76.17, 58.7 APE8-rot-na 28.97 APE67-dihe-in -74.88, -4.9 -52.62, -40.92 APE12-dist-na 999.0 APE11-dist-na 16.2617 APE10-dist-na 12.2316 APE9-dist-out 8.1002 T790M,V948R None None XRAY 2.2 0.204 0.261 C 328.0 296.0 11 30 19 11 [[712, 970]] 1.0 8fv4 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO3B P00533 702 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 3.6573 14.9344 BLBplus -134.55, 162.66 68.08, 49.36 -93.73, 164.43 101.15, 105.54 56.1, 2.84 out-out out 13.7673 Saltbr-out 13.9706 HRD-in -68.15, -46.1 73.95, -11.19 out-out-out SNCooo out-out ActLoopNT-out 6.8421 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 106.24 APE8-dihe-in -74.12, 71.61 APE8-rot-na 27.49 APE67-dihe-in -65.2, -1.6 -53.66, -41.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1295 T790M,V948R None None XRAY 2.49 0.231 0.269 B 328.0 291.0 18 30 17 13 [[712, 970]] 1.0 8to3 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO4B P00533 702 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 4.3212 13.8382 BLBplus -145.22, 172.21 45.08, 44.37 -91.4, 153.78 67.05, 82.38 64.94, 7.17 out-out out 14.0112 Saltbr-out 13.4798 HRD-in -63.39, -70.27 96.97, -15.43 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.51 APE8-dihe-in -77.84, 67.96 APE8-rot-na 10.85 APE67-dihe-in -65.93, -24.75 -51.27, -47.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5367 T790M,V948R None None XRAY 2.99 0.176 0.231 B 328.0 290.0 18 30 16 14 [[712, 970]] 1.0 8to4 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4ZSED P00533 701 1015 1210.0 ANP:4001 ATPlike Inactive DFGin 4.4807 13.6994 BLBplus -139.61, 164.7 66.53, 26.19 -71.23, 138.48 53.66, 91.47 74.43, 7.23 out-out out 13.877 Saltbr-out 13.6856 HRD-in -70.41, -53.51 80.03, -13.83 out-out-none SNCoon out-none ActLoopNT-out 6.5216 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.0 APE8-dihe-in -83.67, 68.18 APE8-rot-na 28.71 APE67-dihe-in -64.05, -23.47 -60.9, -39.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.9891 T790M,V948R None None XRAY 1.97 0.191 0.213 D 331.0 297.0 14 30 18 12 [[712, 970]] 1.0 4zse TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5D41B P00533 701 1014 1210.0 ANP:2001 ATPlike Inactive DFGin 3.9465 14.2825 BLBplus -122.59, 173.39 56.77, 40.3 -84.43, 150.38 61.52, 86.97 79.88, -36.14 out-out out 13.6662 Saltbr-out 11.1436 HRD-in -72.27, -56.38 80.95, -10.72 out-out-out SNCooo out-out ActLoopNT-out 6.673 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -30.97 APE9-dihe-in -100.3, 124.18 APE8-dihe-in -72.86, 61.7 APE8-rot-na 30.04 APE67-dihe-in -79.76, 0.67 -51.2, -39.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.5009 APE9-dist-out 8.3525 T790M,V948R None None XRAY 2.31 0.175 0.207 B 331.0 302.0 12 30 18 12 [[712, 970]] 1.0 5d41 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5X2AD P00533 701 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 4.5667 13.491 BLBplus -132.47, 164.02 73.22, 18.47 -66.23, 142.03 48.39, 91.71 77.4, 1.26 out-out out 13.9917 Saltbr-out 14.3497 HRD-in -72.94, -56.49 82.37, -10.91 out-out-out SNCooo out-out ActLoopNT-out 6.4634 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 3.06 APE9-dihe-in -69.62, 129.82 APE8-dihe-in -83.4, 65.28 APE8-rot-na 22.72 APE67-dihe-in -72.49, -3.02 -53.67, -40.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.8971 APE9-dist-out 8.2345 T790M,V948R None None XRAY 1.85 0.176 0.219 D 331.0 297.0 13 30 20 10 [[712, 970]] 1.0 5x2a TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXKB P00533 700 1007 1210.0 ANP:1101 ATPlike Inactive DFGin 4.788 14.3042 BLBplus -133.99, 169.66 58.32, 39.23 -93.88, 160.42 49.41, 87.38 74.89, 999.0 out-out out 13.4903 Saltbr-out 12.3941 HRD-in -66.37, -58.14 81.2, -5.32 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.52 APE8-dihe-in -80.54, 72.01 APE8-rot-na 30.24 APE67-dihe-in -73.85, -4.26 -53.45, -45.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5412 T790M,V948R None None XRAY 3.1 0.223 0.261 B 331.0 290.0 18 30 12 18 [[712, 970]] 1.0 7jxk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXMC P00533 702 1006 1210.0 ANP:1101 ATPlike Inactive DFGin 4.2828 13.994 BLBplus -133.09, 168.24 59.36, 33.1 -80.78, 143.72 58.15, 87.09 66.36, 74.02 out-out out 13.9625 Saltbr-out 13.1185 HRD-in -67.9, -61.75 83.53, -6.82 out-out-none SNCoon out-none ActLoopNT-out 9.0085 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.47 APE8-dihe-in -77.6, 66.96 APE8-rot-na 35.92 APE67-dihe-in -75.2, -5.27 -47.14, -42.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.517 T790M,V948R None None XRAY 2.192 0.228 0.271 C 331.0 285.0 20 30 15 15 [[712, 970]] 1.0 7jxm TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CNOB P00533 698 1015 1210.0 ANP:61001 ATPlike Inactive DFGin 3.8893 14.1511 BLBplus -128.77, 161.65 68.19, 38.17 -78.09, 143.32 56.13, 92.23 54.89, 36.11 out-out out 13.8774 Saltbr-out 12.6073 HRD-in -79.53, -48.18 74.57, -9.86 out-out-out SNCooo out-out ActLoopNT-out 8.1881 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 114.62 APE9-dihe-in -83.89, 124.6 APE8-dihe-in -81.17, 61.86 APE8-rot-na 30.73 APE67-dihe-in -73.98, -7.26 -47.13, -40.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.0922 APE9-dist-out 8.4007 V948R None None XRAY 1.55 0.176 0.203 B 330.0 302.0 16 30 18 12 [[712, 970]] 1.0 5cno TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CNNA P00533 699 1014 1210.0 ANP:61101 ATPlike Inactive DFGin 3.9697 14.1701 BLBplus -125.09, 165.12 65.79, 30.65 -73.26, 142.49 57.23, 92.2 61.04, 28.88 out-out out 14.4189 Saltbr-out 11.3969 HRD-in -77.1, -52.71 74.61, -9.55 out-out-none SNCoon out-none ActLoopNT-out 8.169 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 61.56 APE9-dihe-in -85.48, 136.67 APE8-dihe-in -75.32, 67.13 APE8-rot-na 28.89 APE67-dihe-in -79.02, -2.66 -49.07, -38.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.9974 APE9-dist-in 7.9937 I706Q None None XRAY 1.9 0.183 0.211 A 350.0 300.0 16 30 17 13 [[712, 970]] 1.0 5cnn TYR_EGFR_HUMAN TYR 1.3e-87 299.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1DB P00533 702 1013 1210.0 ANP:1101,NQ1:1102 ATPlike,Type3 Inactive DFGin 4.7371 14.0299 BLBplus -133.29, 171.5 64.7, 17.77 -68.3, 145.06 52.12, 92.58 81.65, -14.38 out-out out 13.7895 Saltbr-out 14.416 HRD-in -75.11, -58.04 81.02, -12.96 out-out-out SNCooo out-out ActLoopNT-out 6.3903 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -53.71 APE8-dihe-in -78.39, 61.97 APE8-rot-na 34.06 APE67-dihe-in -73.46, -6.67 -54.96, -43.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.3559 None None None XRAY 2.4 0.195 0.213 B 327.0 300.0 12 30 18 12 [[712, 970]] 1.0 6p1d TYR_EGFR_HUMAN TYR 6e-88 300.6 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1LA P00533 701 1007 1210.0 ANP:1102,9LL:1103 ATPlike,Type3 Inactive DFGin 5.0904 14.6089 BLBplus -137.99, 174.26 51.86, 38.49 -97.68, 160.33 56.12, 79.32 80.95, 13.49 out-out out 13.0903 Saltbr-out 11.075 HRD-in -66.81, -53.87 69.64, 3.15 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.91 APE8-dihe-in -92.34, 76.37 APE8-rot-na 35.99 APE67-dihe-in -76.25, -4.78 -68.05, -35.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.3608 T790M,V948R None None XRAY 2.8 0.203 0.237 A 327.0 288.0 19 30 13 17 [[712, 970]] 1.0 6p1l TYR_EGFR_HUMAN TYR 6e-88 300.6 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1LC P00533 702 1005 1210.0 ANP:1102,9LL:1103 ATPlike,Type3 Inactive DFGin 4.9465 14.3459 BLBplus -138.12, 175.57 52.19, 39.44 -97.35, 162.11 56.76, 79.57 81.63, 13.51 out-out out 13.0686 Saltbr-out 12.6895 HRD-in -65.46, -53.47 68.76, 3.35 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -21.1 APE8-dihe-in -91.14, 76.85 APE8-rot-na 36.16 APE67-dihe-in -74.42, -4.16 -69.53, -34.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.035 T790M,V948R None None XRAY 2.8 0.203 0.237 C 327.0 280.0 24 30 13 17 [[712, 970]] 1.0 6p1l TYR_EGFR_HUMAN TYR 6e-88 300.6 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1LD P00533 702 1015 1210.0 ANP:1102,9LL:1103 ATPlike,Type3 Inactive DFGin 5.1933 14.6343 BLBplus -136.45, 175.46 51.75, 39.49 -96.95, 158.96 56.24, 81.53 81.72, 11.0 out-out out 13.1546 Saltbr-out 10.9823 HRD-in -66.43, -53.42 65.79, 5.44 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.86 APE8-dihe-in -92.75, 77.55 APE8-rot-na 35.81 APE67-dihe-in -75.19, -4.23 -67.58, -35.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.0944 T790M,V948R None None XRAY 2.8 0.203 0.237 D 327.0 296.0 17 30 13 17 [[712, 970]] 1.0 6p1l TYR_EGFR_HUMAN TYR 6e-88 300.6 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P8QA P00533 699 1019 1210.0 ANP:2001,O57:2002 ATPlike,Type3 Inactive DFGin 5.2914 14.4671 BLBplus -136.39, 166.39 65.62, 19.67 -68.64, 141.86 47.45, 96.29 88.91, -15.41 out-out out 13.7934 Saltbr-out 13.3942 HRD-in -77.48, -60.3 86.7, -15.68 out-out-none SNCoon out-none ActLoopNT-out 6.9269 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 121.69 APE8-dihe-in -82.28, 70.48 APE8-rot-na 31.78 APE67-dihe-in -69.54, -10.7 -59.7, -40.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5228 T790M,V948R None None XRAY 1.9 0.169 0.195 A 327.0 309.0 12 30 18 12 [[712, 970]] 1.0 6p8q TYR_EGFR_HUMAN TYR 6e-88 300.6 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6XL4D P00533 700 1013 1210.0 ANP:1102,NQ1:1103 ATPlike,Type3 Inactive DFGin 4.8901 14.2469 BLBplus -133.2, 175.82 65.76, 18.85 -77.15, 145.6 52.8, 92.59 74.56, -2.19 out-out out 13.6236 Saltbr-out 15.8297 HRD-in -71.69, -57.79 76.59, -4.88 out-out-none SNCoon out-none ActLoopNT-out 6.4776 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.17 APE8-dihe-in -78.79, 71.74 APE8-rot-na 31.74 APE67-dihe-in -74.38, -1.99 -55.71, -41.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.7702 T790M,V948R None None XRAY 2.06 0.216 0.252 D 328.0 300.0 14 30 19 11 [[712, 970]] 1.0 6xl4 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO4C P00533 702 1013 1210.0 ANP:1102,IXR:1103 ATPlike,Type3 Inactive DFGin 5.3236 14.7029 BLBplus -141.27, 171.12 64.77, 53.38 -109.59, 167.64 42.74, 100.72 59.4, 999.0 out-out out 13.2945 Saltbr-out 12.3497 HRD-in -63.29, -59.94 84.01, 4.45 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.05 APE8-dihe-in -90.09, 61.93 APE8-rot-na 21.85 APE67-dihe-in -81.47, -6.07 -53.96, -24.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8359 T790M,V948R None None XRAY 2.99 0.176 0.231 C 328.0 289.0 18 30 12 18 [[712, 970]] 1.0 8to4 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO4D P00533 702 1005 1210.0 ANP:1102,IXR:1103 ATPlike,Type3 Inactive DFGin 4.5511 14.1875 BLBplus -127.27, 157.13 78.08, 44.22 -85.23, -172.29 38.08, 100.01 106.69, 999.0 out-out out 13.6561 Saltbr-out 10.8245 HRD-in -72.87, -44.75 69.45, -7.84 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 105.73 APE8-dihe-in -81.92, 60.79 APE8-rot-na 34.7 APE67-dihe-in -66.67, -11.33 -39.66, -48.35 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6599 T790M,V948R None None XRAY 2.99 0.176 0.231 D 328.0 283.0 20 30 12 18 [[712, 970]] 1.0 8to4 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5D41A P00533 698 1014 1210.0 ANP:1102,57N:1103 ATPlike,Type3 Inactive DFGin 4.968 14.448 BLBplus -130.27, 169.23 61.95, 37.88 -93.29, 173.71 50.74, 86.35 79.65, -10.55 out-out out 12.815 Saltbr-out 11.3738 HRD-in -77.25, -55.76 78.51, -14.31 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 155.57 APE8-dihe-in -80.12, 74.82 APE8-rot-na 31.53 APE67-dihe-in -75.45, -3.11 -51.46, -43.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8002 T790M,V948R None None XRAY 2.31 0.175 0.207 A 331.0 300.0 17 30 13 17 [[712, 970]] 1.0 5d41 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6DUKA P00533 701 1006 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.4162 14.8008 BLBplus -133.89, 165.03 66.94, 37.08 -93.36, 166.29 58.42, 86.37 91.91, 6.11 out-out out 13.9176 Saltbr-out 14.1793 HRD-in -76.73, -64.87 85.37, -18.97 out-out-out SNCooo out-out ActLoopNT-out 7.4382 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.39, -10.84 APE9-dihe-in -125.5, 116.79 APE8-dihe-in -80.16, 76.04 APE8-rot-na 31.69 APE67-dihe-in -76.14, -1.34 -58.18, -44.83 APE12-dist-na 17.3641 APE11-dist-na 15.2023 APE10-dist-na 11.7763 APE9-dist-in 7.3106 T790M,V948R None None XRAY 2.2 0.191 0.223 A 331.0 306.0 0 30 30 0 [[712, 970]] 1.0 6duk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6DUKB P00533 699 1007 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.6806 14.6502 BLBplus -136.44, 165.42 61.83, 36.22 -89.54, 161.73 53.44, 89.67 90.48, 19.39 out-out out 13.8125 Saltbr-out 14.7331 HRD-in -68.48, -61.78 82.94, -15.18 out-out-none SNCoon out-none ActLoopNT-out 7.2922 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.53 APE8-dihe-in -76.17, 63.91 APE8-rot-na 26.99 APE67-dihe-in -79.83, -2.27 -51.77, -41.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.9222 T790M,V948R None None XRAY 2.2 0.191 0.223 B 331.0 296.0 13 30 17 13 [[712, 970]] 1.0 6duk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6DUKC P00533 699 1007 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.6614 14.3909 BLBplus -137.36, 170.05 61.14, 32.95 -87.42, 165.36 52.89, 84.68 86.51, 15.0 out-out out 13.7494 Saltbr-out 12.3873 HRD-in -66.04, -61.2 80.35, -9.27 out-out-none SNCoon out-none ActLoopNT-out 8.2862 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 116.92 APE8-dihe-in -77.64, 67.39 APE8-rot-na 32.93 APE67-dihe-in -71.69, -8.16 -55.72, -42.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8229 T790M,V948R None None XRAY 2.2 0.191 0.223 C 331.0 295.0 14 30 16 14 [[712, 970]] 1.0 6duk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6DUKD P00533 701 1007 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.6052 14.6344 BLBplus -137.83, 165.45 65.63, 29.61 -82.3, 167.28 56.12, 84.13 94.16, 13.47 out-out out 14.053 Saltbr-out 14.8858 HRD-in -74.03, -57.71 81.46, -18.53 out-out-out SNCooo out-out ActLoopNT-out 7.3207 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -76.03, 11.31 APE9-dihe-in -134.89, 121.24 APE8-dihe-in -86.59, 77.19 APE8-rot-na 34.21 APE67-dihe-in -72.84, -7.51 -59.65, -43.13 APE12-dist-na 17.7472 APE11-dist-na 15.5553 APE10-dist-na 11.9033 APE9-dist-in 7.5388 T790M,V948R None None XRAY 2.2 0.191 0.223 D 331.0 307.0 0 30 30 0 [[712, 970]] 1.0 6duk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6DUKE P00533 698 1007 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.7057 14.387 BLBplus -132.31, 167.27 63.11, 42.82 -102.17, 159.55 52.62, 85.09 88.84, 16.78 out-out out 13.7684 Saltbr-out 14.3613 HRD-in -70.33, -59.21 85.76, -23.74 out-out-none SNCoon out-none ActLoopNT-out 7.6865 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 1.83 APE9-dihe-in -127.74, 112.92 APE8-dihe-in -68.38, 64.27 APE8-rot-na 21.48 APE67-dihe-in -73.72, -8.33 -52.7, -41.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.2913 APE9-dist-in 7.9406 T790M,V948R None None XRAY 2.2 0.191 0.223 E 331.0 298.0 12 30 18 12 [[712, 970]] 1.0 6duk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6DUKF P00533 701 1009 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.6528 14.6121 BLBplus -133.82, 164.75 63.96, 32.85 -83.32, 163.7 53.83, 93.49 88.31, 19.42 out-out out 14.1084 Saltbr-out 15.1439 HRD-in -67.38, -62.37 88.35, -19.9 out-out-none SNCoon out-none ActLoopNT-out 7.3188 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.72 APE8-dihe-in -80.72, 70.63 APE8-rot-na 32.98 APE67-dihe-in -75.6, -2.87 -62.49, -36.24 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8407 T790M,V948R None None XRAY 2.2 0.191 0.223 F 331.0 298.0 11 30 19 11 [[712, 970]] 1.0 6duk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXKD P00533 700 1007 1210.0 ANP:1101,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.8614 14.45 BLBplus -134.29, 170.65 60.11, 37.92 -95.07, 160.21 48.8, 86.41 74.63, 26.88 out-out out 13.4574 Saltbr-out 11.7626 HRD-in -66.46, -59.56 80.54, -6.1 out-out-none SNCoon out-none ActLoopNT-out 8.9029 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.41 APE8-dihe-in -81.29, 71.57 APE8-rot-na 30.4 APE67-dihe-in -73.66, -4.05 -53.54, -44.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4718 T790M,V948R None None XRAY 3.1 0.223 0.261 D 331.0 294.0 14 30 16 14 [[712, 970]] 1.0 7jxk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXMD P00533 700 1007 1210.0 ANP:1101,9LL:1103 ATPlike,Type3 Inactive DFGin 4.9516 14.3368 BLBplus -135.28, 170.25 61.86, 31.57 -85.27, 155.14 53.77, 85.22 78.23, 19.31 out-out out 13.0485 Saltbr-out 11.8943 HRD-in -66.52, -63.02 84.71, -6.37 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.04 APE8-dihe-in -80.42, 66.88 APE8-rot-na 32.97 APE67-dihe-in -76.05, -3.45 -51.47, -42.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.762 T790M,V948R None None XRAY 2.192 0.228 0.271 D 331.0 291.0 17 30 13 17 [[712, 970]] 1.0 7jxm TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXPA P00533 700 1007 1210.0 ANP:1101,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.7467 14.6167 BLBplus -136.18, 166.76 64.66, 34.04 -92.53, 168.9 56.02, 85.41 85.63, 11.86 out-out out 13.9879 Saltbr-out 14.3068 HRD-in -74.54, -64.28 89.28, -17.63 out-out-out SNCooo out-out ActLoopNT-out 7.5088 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -97.63, -15.8 APE9-dihe-in -113.05, 126.54 APE8-dihe-in -83.29, 68.9 APE8-rot-na 33.94 APE67-dihe-in -74.36, -3.96 -52.3, -47.62 APE12-dist-na 17.0956 APE11-dist-na 14.9557 APE10-dist-na 11.6928 APE9-dist-in 7.4058 T790M,V948R None None XRAY 2.16 0.214 0.247 A 331.0 308.0 0 30 30 0 [[712, 970]] 1.0 7jxp TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXPB P00533 700 1007 1210.0 ANP:1101,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.6706 14.5109 BLBplus -135.21, 165.17 64.35, 37.85 -90.15, 169.17 53.82, 91.67 84.59, 7.68 out-out out 13.7558 Saltbr-out 13.8881 HRD-in -70.65, -63.17 87.36, -17.28 out-out-out SNCooo out-out ActLoopNT-out 7.5923 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -97.44, -17.16 APE9-dihe-in -126.66, 129.43 APE8-dihe-in -78.52, 67.74 APE8-rot-na 34.72 APE67-dihe-in -76.32, -3.64 -51.52, -45.13 APE12-dist-na 17.4376 APE11-dist-na 15.2142 APE10-dist-na 12.2746 APE9-dist-in 7.6166 T790M,V948R None None XRAY 2.16 0.214 0.247 B 331.0 308.0 0 30 30 0 [[712, 970]] 1.0 7jxp TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXPD P00533 700 1007 1210.0 ANP:1101,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.766 14.6606 BLBplus -135.69, 167.35 65.6, 33.96 -89.97, 168.72 55.6, 87.2 84.96, 9.82 out-out out 13.5259 Saltbr-out 11.2829 HRD-in -71.06, -65.03 87.13, -14.24 out-out-none SNCoon out-none ActLoopNT-out 8.0039 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.01 APE8-dihe-in -77.89, 69.26 APE8-rot-na 33.29 APE67-dihe-in -74.9, -2.69 -52.27, -42.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.7443 T790M,V948R None None XRAY 2.16 0.214 0.247 D 331.0 294.0 14 30 16 14 [[712, 970]] 1.0 7jxp TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXPF P00533 700 1007 1210.0 ANP:1101,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.9745 14.7024 BLBplus -136.82, 166.82 61.14, 36.57 -93.57, 171.83 53.4, 92.66 83.03, -0.51 out-out out 13.6744 Saltbr-out 11.5698 HRD-in -71.01, -63.71 87.17, -13.68 out-out-none SNCoon out-none ActLoopNT-out 9.118 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.33 APE8-dihe-in -78.62, 69.48 APE8-rot-na 32.72 APE67-dihe-in -72.69, -4.28 -52.16, -45.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6211 T790M,V948R None None XRAY 2.16 0.214 0.247 F 331.0 294.0 14 30 16 14 [[712, 970]] 1.0 7jxp TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXQB P00533 701 1007 1210.0 ANP:1102,VNS:1103 ATPlike,Type3 Inactive DFGin 4.9153 14.4376 BLBplus -136.8, 171.78 58.87, 35.86 -91.33, 162.29 51.51, 87.21 80.67, 16.0 out-out out 13.3352 Saltbr-out 12.6978 HRD-in -67.21, -58.71 77.88, -12.51 out-out-none SNCoon out-none ActLoopNT-out 8.8959 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -177.71 APE9-dihe-in -105.47, 135.84 APE8-dihe-in -83.2, 67.78 APE8-rot-na 33.37 APE67-dihe-in -74.22, -7.65 -49.73, -41.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.7343 APE9-dist-in 7.6451 T790M,V948R None None XRAY 1.83 0.185 0.218 B 331.0 297.0 10 30 20 10 [[712, 970]] 1.0 7jxq TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXQD P00533 700 1007 1210.0 ANP:1102,VNS:1103 ATPlike,Type3 Inactive DFGin 4.8444 14.3284 BLBplus -136.14, 172.56 58.98, 36.18 -92.84, 162.13 51.55, 88.05 79.36, 17.26 out-out out 13.4204 Saltbr-out 11.8902 HRD-in -65.12, -58.0 78.92, -12.53 out-out-none SNCoon out-none ActLoopNT-out 8.9401 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.09 APE8-dihe-in -80.19, 68.24 APE8-rot-na 33.29 APE67-dihe-in -74.77, -5.19 -50.69, -44.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5794 T790M,V948R None None XRAY 1.83 0.185 0.218 D 331.0 298.0 10 30 20 10 [[712, 970]] 1.0 7jxq TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7LTXA P00533 700 1007 1210.0 ANP:1101,YFA:1103 ATPlike,Type3 Inactive DFGin 5.2481 14.5643 BLBplus -135.35, 163.04 64.03, 33.94 -82.37, 179.4 48.16, 87.26 -162.42, -162.89 out-out out 13.1822 Saltbr-out 10.5993 HRD-in -67.02, -61.48 82.46, -5.8 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.93 APE8-dihe-in -80.94, 68.72 APE8-rot-na 31.43 APE67-dihe-in -70.18, -9.53 -51.9, -44.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.02 T790M,V948R None None XRAY 2.3 0.187 0.216 A 331.0 292.0 16 30 14 16 [[712, 970]] 1.0 7ltx TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7LTXB P00533 700 1007 1210.0 ANP:1101,YFA:1103 ATPlike,Type3 Inactive DFGin 5.1967 14.4947 BLBplus -136.17, 169.66 62.42, 34.77 -78.22, 170.05 42.44, 90.17 -152.16, -165.64 out-out out 13.123 Saltbr-out 10.2264 HRD-in -65.63, -61.11 82.51, -6.05 out-out-none SNCoon out-none ActLoopNT-out 9.2387 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.13 APE8-dihe-in -82.01, 66.41 APE8-rot-na 31.46 APE67-dihe-in -73.58, -7.26 -49.71, -42.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8286 T790M,V948R None None XRAY 2.3 0.187 0.216 B 331.0 293.0 15 30 15 15 [[712, 970]] 1.0 7ltx TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7LTXC P00533 700 1007 1210.0 ANP:1101,YFA:1103 ATPlike,Type3 Inactive DFGin 5.1227 14.5107 BLBplus -136.55, 165.71 63.6, 32.17 -87.45, 156.27 46.73, 94.27 148.1, 156.05 out-out out 13.0711 Saltbr-out 10.0756 HRD-in -65.09, -59.89 81.29, -6.26 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.8 APE8-dihe-in -79.63, 67.92 APE8-rot-na 31.3 APE67-dihe-in -72.94, -5.81 -52.93, -44.7 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8643 T790M,V948R None None XRAY 2.3 0.187 0.216 C 331.0 292.0 16 30 14 16 [[712, 970]] 1.0 7ltx TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7LTXD P00533 700 1007 1210.0 ANP:1101,YFA:1103 ATPlike,Type3 Inactive DFGin 5.3456 14.4432 BLBplus -137.08, 165.99 63.56, 34.05 -81.77, 167.16 44.82, 94.68 -177.57, 165.83 out-out out 12.9855 Saltbr-out 10.3401 HRD-in -68.33, -62.57 83.39, -4.99 out-out-none SNCoon out-none ActLoopNT-out 9.4938 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.9 APE8-dihe-in -80.86, 67.56 APE8-rot-na 30.12 APE67-dihe-in -73.23, -5.97 -50.49, -42.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.9168 T790M,V948R None None XRAY 2.3 0.187 0.216 D 331.0 293.0 15 30 15 15 [[712, 970]] 1.0 7ltx TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8GB4A P00533 700 1007 1210.0 ANP:1102,YW5:1103 ATPlike,Type3 Inactive DFGin 4.7378 14.7779 BLBplus -140.96, 174.92 57.37, 44.23 -99.53, 158.98 50.67, 86.24 74.62, 16.37 out-out out 13.3553 Saltbr-out 11.6982 HRD-in -69.91, -59.18 79.33, -9.52 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.01 APE8-dihe-in -76.27, 67.14 APE8-rot-na 30.24 APE67-dihe-in -75.65, -5.48 -58.37, -41.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.0578 T790M,V948R None None XRAY 2.59 0.23 0.254 A 331.0 292.0 16 30 14 16 [[712, 970]] 1.0 8gb4 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8GB4B P00533 700 1007 1210.0 ANP:1102,YW5:1103 ATPlike,Type3 Inactive DFGin 4.8583 14.6814 BLBplus -140.61, 174.15 57.09, 43.59 -100.33, 162.57 51.99, 86.76 77.41, 18.84 out-out out 13.39 Saltbr-out 10.5312 HRD-in -69.24, -58.17 79.24, -10.08 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.16 APE8-rot-na 30.06 APE67-dihe-in -75.09, -5.85 -58.81, -39.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,V948R None None XRAY 2.59 0.23 0.254 B 331.0 290.0 18 30 12 18 [[712, 970]] 1.0 8gb4 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8GB4C P00533 700 1012 1210.0 ANP:1102,YW5:1103 ATPlike,Type3 Inactive DFGin 4.7325 14.6021 BLBplus -141.16, 174.43 57.44, 44.8 -99.46, 158.79 49.11, 85.48 74.36, 22.53 out-out out 13.1853 Saltbr-out 11.5365 HRD-in -70.07, -59.0 77.64, -8.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.65 APE8-dihe-in -76.99, 66.94 APE8-rot-na 30.24 APE67-dihe-in -75.42, -5.6 -59.05, -41.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.014 T790M,V948R None None XRAY 2.59 0.23 0.254 C 331.0 297.0 16 30 14 16 [[712, 970]] 1.0 8gb4 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8GB4D P00533 700 1007 1210.0 ANP:1102,YW5:1103 ATPlike,Type3 Inactive DFGin 4.686 14.6978 BLBplus -141.21, 175.0 57.29, 43.49 -99.79, 159.92 51.61, 87.18 76.57, 22.15 out-out out 13.5607 Saltbr-out 10.9102 HRD-in -69.19, -58.43 79.07, -10.45 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 65.97 APE8-rot-na 30.21 APE67-dihe-in -74.96, -5.48 -59.31, -40.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,V948R None None XRAY 2.59 0.23 0.254 D 331.0 291.0 17 30 13 17 [[712, 970]] 1.0 8gb4 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7K1IA P00533 700 1007 1210.0 ANP:1102,VNS:1103 ATPlike,Type3 Inactive DFGin 4.8367 14.4122 BLBplus -124.92, 173.52 55.34, 38.4 -93.27, 168.4 51.69, 86.03 70.99, 11.24 out-out out 13.5963 Saltbr-out 12.2121 HRD-in -68.02, -55.76 76.66, -7.58 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.86 APE8-dihe-in -84.0, 73.03 APE8-rot-na 29.2 APE67-dihe-in -72.27, -9.54 -58.41, -42.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4195 L858R,V948R None None XRAY 3.202 0.266 0.311 A 331.0 288.0 20 30 13 17 [[712, 970]] 1.0 7k1i TYR_EGFR_HUMAN TYR 8.5e-87 296.8 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1DC P00533 702 1006 1210.0 NQ1:1101,ANP:1102 Type3,ATPlike Inactive DFGin 5.3825 14.4593 BLBplus -142.0, 171.97 66.8, 29.01 -86.08, 152.7 44.82, 92.23 73.36, -11.9 out-out out 13.6137 Saltbr-out 13.7361 HRD-in -69.23, -60.69 76.65, -2.9 out-out-none SNCoon out-none ActLoopNT-out 6.7847 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 96.45 APE8-dihe-in -76.51, 79.09 APE8-rot-na 31.04 APE67-dihe-in -75.49, -1.74 -58.74, -40.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.2578 None None None XRAY 2.4 0.195 0.213 C 327.0 292.0 13 30 17 13 [[712, 970]] 1.0 6p1d TYR_EGFR_HUMAN TYR 6e-88 300.6 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1DD P00533 701 1008 1210.0 NQ1:1101,ANP:1102 Type3,ATPlike Inactive DFGin 4.7963 14.1019 BLBplus -132.01, 171.13 65.01, 17.93 -68.87, 143.86 51.94, 90.04 79.55, -15.22 out-out out 13.6224 Saltbr-out 13.7342 HRD-in -75.21, -58.43 80.83, -11.58 out-out-none SNCoon out-none ActLoopNT-out 6.6334 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.5 APE8-dihe-in -78.23, 70.43 APE8-rot-na 33.16 APE67-dihe-in -74.16, -5.23 -50.48, -45.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.2506 None None None XRAY 2.4 0.195 0.213 D 327.0 295.0 13 30 17 13 [[712, 970]] 1.0 6p1d TYR_EGFR_HUMAN TYR 6e-88 300.6 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXQA P00533 700 1007 1210.0 VNS:1102,ANP:1103 Type3,ATPlike Inactive DFGin 4.8599 14.5423 BLBplus -136.59, 171.99 58.78, 36.07 -93.08, 163.3 53.5, 85.99 81.0, 16.2 out-out out 13.5999 Saltbr-out 11.4015 HRD-in -66.89, -59.97 80.26, -12.87 out-out-out SNCooo out-out ActLoopNT-out 8.8337 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 0.37 APE9-dihe-in -62.95, 136.95 APE8-dihe-in -80.94, 64.03 APE8-rot-na 32.82 APE67-dihe-in -75.31, -4.79 -52.17, -43.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.4112 APE9-dist-out 8.2105 T790M,V948R None None XRAY 1.83 0.185 0.218 A 331.0 296.0 12 30 18 12 [[712, 970]] 1.0 7jxq TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXQC P00533 700 1007 1210.0 VNS:1102,ANP:1103 Type3,ATPlike Inactive DFGin 4.7845 14.4525 BLBplus -135.56, 173.47 59.34, 36.33 -94.04, 161.61 52.57, 85.94 80.36, 16.26 out-out out 13.5268 Saltbr-out 12.0328 HRD-in -65.88, -57.49 78.82, -12.32 out-out-none SNCoon out-none ActLoopNT-out 8.8194 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.15 APE8-dihe-in -80.46, 67.52 APE8-rot-na 31.26 APE67-dihe-in -73.66, -6.11 -51.25, -43.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4339 T790M,V948R None None XRAY 1.83 0.185 0.218 C 331.0 298.0 10 30 20 10 [[712, 970]] 1.0 7jxq TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1DA P00533 700 1021 1210.0 ANP:1101 ATPlike Inactive DFGin 5.3014 16.4366 BLBtrans -129.26, 172.58 65.52, 23.29 -64.33, 142.93 151.16, 79.23 78.73, -15.31 out-out out 13.5195 Saltbr-out 12.421 HRD-in -76.98, -57.73 83.77, -12.82 out-out-none SNCoon out-none ActLoopNT-out 7.141 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 149.92 APE9-dihe-in -115.71, 137.77 APE8-dihe-in -79.58, 71.21 APE8-rot-na 32.94 APE67-dihe-in -73.74, -5.13 -51.22, -45.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.1838 APE9-dist-in 7.6772 None None None XRAY 2.4 0.195 0.213 A 327.0 309.0 13 30 17 13 [[712, 970]] 1.0 6p1d TYR_EGFR_HUMAN TYR 6e-88 300.6 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6WAKB P00533 701 1020 1210.0 ANP:1101 ATPlike Inactive DFGin 5.1768 16.2307 BLBtrans -117.23, 173.55 69.28, 15.65 -59.01, 135.6 148.98, 94.52 90.59, -20.79 out-out out 13.9491 Saltbr-out 13.5428 HRD-in -74.15, -58.44 85.37, -10.97 out-out-none SNCoon out-none ActLoopNT-out 6.4805 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -3.86 APE9-dihe-in -108.7, 124.16 APE8-dihe-in -81.26, 64.66 APE8-rot-na 31.83 APE67-dihe-in -71.85, -2.7 -48.1, -51.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.3657 APE9-dist-in 7.8264 T790M,V948R None None XRAY 2.4 0.219 0.23 B 328.0 316.0 4 30 26 4 [[712, 970]] 1.0 6wak TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6WXNB P00533 701 1021 1210.0 ANP:1101 ATPlike Inactive DFGin 5.2834 16.2947 BLBtrans -123.51, 174.07 66.96, 19.19 -61.23, 137.15 158.07, 75.44 91.96, -18.66 out-out out 13.5648 Saltbr-out 13.5233 HRD-in -75.09, -55.39 80.46, -8.33 out-out-none SNCoon out-none ActLoopNT-out 6.4801 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -21.86 APE9-dihe-in -115.99, 110.82 APE8-dihe-in -78.55, 77.75 APE8-rot-na 31.2 APE67-dihe-in -73.85, -5.28 -56.42, -42.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.8252 APE9-dist-in 7.8441 T790M,V948R None None XRAY 1.76 0.209 0.235 B 328.0 303.0 11 30 19 11 [[712, 970]] 1.0 6wxn TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8FV3B P00533 701 1021 1210.0 ANP:1102 ATPlike Inactive DFGin 5.4387 16.4957 BLBtrans -118.64, 177.37 63.4, 20.55 -58.75, 145.81 159.38, 77.34 77.7, -11.94 out-out out 13.9071 Saltbr-out 12.6093 HRD-in -79.27, -57.12 85.07, -16.18 out-out-none SNCoon out-none ActLoopNT-out 6.5505 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -85.47 APE9-dihe-in -94.5, 111.51 APE8-dihe-in -78.45, 79.51 APE8-rot-na 26.67 APE67-dihe-in -72.96, -7.53 -57.83, -45.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.1584 APE9-dist-in 7.6087 T790M,V948R None None XRAY 2.1 0.191 0.226 B 328.0 307.0 12 30 18 12 [[712, 970]] 1.0 8fv3 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8FV3D P00533 701 1008 1210.0 ANP:1102 ATPlike Inactive DFGin 5.123 16.0686 BLBtrans -118.91, 178.66 63.22, 20.1 -58.76, 136.59 151.59, 72.8 86.53, -14.56 out-out out 13.6355 Saltbr-out 11.8782 HRD-in -77.73, -54.76 83.51, -15.49 out-out-none SNCoon out-none ActLoopNT-out 6.6865 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -35.35 APE9-dihe-in -75.26, 139.37 APE8-dihe-in -77.41, 75.08 APE8-rot-na 30.35 APE67-dihe-in -77.52, -1.37 -56.44, -41.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.9892 APE9-dist-in 7.8559 T790M,V948R None None XRAY 2.1 0.191 0.226 D 328.0 295.0 13 30 18 12 [[712, 970]] 1.0 8fv3 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8FV4A P00533 701 1013 1210.0 ANP:1102 ATPlike Inactive DFGin 5.115 16.0834 BLBtrans -131.04, 178.71 63.39, 21.89 -65.77, 133.12 153.56, 67.25 81.77, -5.74 out-out out 13.9648 Saltbr-out 14.3656 HRD-in -75.29, -65.35 93.54, -10.41 out-out-out SNCooo out-out ActLoopNT-out 6.6138 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.22 APE8-dihe-in -79.99, 70.44 APE8-rot-na 34.65 APE67-dihe-in -69.8, 5.09 -60.12, -39.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.0271 T790M,V948R None None XRAY 2.2 0.204 0.261 A 328.0 298.0 15 30 17 13 [[712, 970]] 1.0 8fv4 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO3C P00533 702 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 5.7531 16.5332 BLBtrans -133.38, -174.65 59.98, 24.74 -65.74, 136.64 157.32, 80.88 79.44, -13.7 out-out out 13.6547 Saltbr-out 13.5313 HRD-in -66.43, -56.05 80.37, -11.56 out-out-out SNCooo out-out ActLoopNT-out 6.3729 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.97 APE8-dihe-in -84.11, 59.51 APE8-rot-na 29.31 APE67-dihe-in -74.18, -0.3 -51.78, -42.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1735 T790M,V948R None None XRAY 2.49 0.231 0.269 C 328.0 295.0 16 30 17 13 [[712, 970]] 1.0 8to3 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO3D P00533 702 1008 1210.0 ANP:1102 ATPlike Inactive DFGin 6.2656 16.7122 BLBtrans -127.69, 172.31 68.6, 30.15 -69.25, 140.14 165.75, 69.84 67.25, -4.22 out-out out 14.3859 Saltbr-out 13.1993 HRD-in -68.61, -53.44 82.24, -15.94 out-out-out SNCooo out-out ActLoopNT-out 6.5519 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 120.24 APE8-dihe-in -79.84, 75.73 APE8-rot-na 31.27 APE67-dihe-in -78.58, -0.75 -60.94, -39.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.144 T790M,V948R None None XRAY 2.49 0.231 0.269 D 328.0 293.0 14 30 17 13 [[712, 970]] 1.0 8to3 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO4A P00533 701 1021 1210.0 ANP:1102 ATPlike Inactive DFGin 5.6288 16.5475 BLBtrans -124.14, -173.94 46.92, 31.67 -57.81, 155.21 158.64, 67.25 48.87, 11.58 out-out out 13.9601 Saltbr-out 13.5608 HRD-in -72.61, -58.43 93.96, -37.09 out-out-none SNCoon out-none ActLoopNT-out 6.9316 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 82.65 APE8-dihe-in -66.65, 104.87 APE8-rot-na 26.84 APE67-dihe-in -69.56, -10.93 -75.01, -49.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.7236 T790M,V948R None None XRAY 2.99 0.176 0.231 A 328.0 300.0 16 30 17 13 [[712, 970]] 1.0 8to4 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4ZSEA P00533 699 1007 1210.0 ANP:1101 ATPlike Inactive DFGin 5.3349 16.1805 BLBtrans -132.89, 171.35 59.18, 30.95 -64.3, 136.47 153.66, 69.99 84.54, -7.18 out-out out 13.4098 Saltbr-out 12.5416 HRD-in -69.44, -53.13 80.36, -12.32 out-out-none SNCoon out-none ActLoopNT-out 6.4997 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 151.84 APE9-dihe-in -73.75, 154.61 APE8-dihe-in -84.04, 78.01 APE8-rot-na 31.44 APE67-dihe-in -73.82, -9.83 -53.67, -42.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.7536 APE9-dist-in 7.6313 T790M,V948R None None XRAY 1.97 0.191 0.213 A 331.0 297.0 12 30 18 12 [[712, 970]] 1.0 4zse TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4ZSEB P00533 698 1022 1210.0 ANP:2001 ATPlike Inactive DFGin 5.4426 16.5343 BLBtrans -132.18, 168.84 69.74, 21.23 -63.33, 134.02 158.02, 77.95 88.87, -12.59 out-out out 13.5937 Saltbr-out 12.7288 HRD-in -70.54, -56.98 84.69, -9.62 out-out-none SNCoon out-none ActLoopNT-out 6.279 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -169.23 APE9-dihe-in -113.21, 138.46 APE8-dihe-in -83.6, 77.16 APE8-rot-na 29.29 APE67-dihe-in -64.08, -26.4 -59.09, -39.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.0951 APE9-dist-in 7.6641 T790M,V948R None None XRAY 1.97 0.191 0.213 B 331.0 313.0 12 30 18 12 [[712, 970]] 1.0 4zse TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4ZSEC P00533 700 1013 1210.0 ANP:3001 ATPlike Inactive DFGin 5.5274 16.5509 BLBtrans -132.06, 169.7 72.1, 15.79 -57.63, 131.91 161.52, 79.23 90.56, -14.81 out-out out 13.4639 Saltbr-out 12.8398 HRD-in -70.03, -52.52 81.38, -14.98 out-out-none SNCoon out-none ActLoopNT-out 6.2175 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.83 APE8-dihe-in -83.98, 70.07 APE8-rot-na 31.43 APE67-dihe-in -69.54, -11.42 -60.89, -38.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.9162 T790M,V948R None None XRAY 1.97 0.191 0.213 C 331.0 301.0 13 30 17 13 [[712, 970]] 1.0 4zse TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXMA P00533 700 1007 1210.0 ANP:1101 ATPlike Inactive DFGin 4.9584 16.1723 BLBtrans -132.35, 172.29 62.1, 35.15 -75.21, 146.26 142.71, 77.54 74.06, -11.26 out-out out 13.8943 Saltbr-out 13.3399 HRD-in -71.64, -59.02 81.62, -5.92 out-out-none SNCoon out-none ActLoopNT-out 8.0723 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 131.88 APE8-dihe-in -79.6, 70.11 APE8-rot-na 34.33 APE67-dihe-in -76.06, -4.61 -47.57, -45.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5303 T790M,V948R None None XRAY 2.192 0.228 0.271 A 331.0 287.0 18 30 16 14 [[712, 970]] 1.0 7jxm TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2GS7A P00533 703 1012 1210.0 ANP:60301 ATPlike Inactive DFGin 5.3734 16.6335 BLBtrans -99.51, 171.1 60.81, 33.31 -69.51, 142.46 163.35, 73.66 92.75, -41.51 out-out out 14.0894 Saltbr-out 13.0754 HRD-in -69.91, -45.27 73.69, -18.97 out-out-out SNCooo out-out ActLoopNT-out 6.362 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 134.47 APE9-dihe-in -142.48, 136.32 APE8-dihe-in -67.69, 63.71 APE8-rot-na 37.05 APE67-dihe-in -69.28, 11.68 -49.57, -49.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.0118 APE9-dist-out 8.2 V948R None None XRAY 2.6 0.258 0.298 A 330.0 281.0 4 30 26 4 [[712, 970]] 1.0 2gs7 TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2GS7B P00533 701 1016 1210.0 ANP:60302 ATPlike Inactive DFGin 5.284 16.3489 BLBtrans -104.25, 165.26 71.85, 26.96 -61.96, 139.7 163.92, 72.26 85.01, -32.88 out-out out 13.995 Saltbr-out 14.3086 HRD-in -67.25, -42.1 68.95, -3.07 out-out-none SNCoon out-none ActLoopNT-out 6.4734 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 151.84 APE9-dihe-in -148.05, 134.8 APE8-dihe-in -62.95, 72.83 APE8-rot-na 33.79 APE67-dihe-in -67.93, 1.22 -55.72, -45.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.1301 APE9-dist-in 7.9025 V948R None None XRAY 2.6 0.258 0.298 B 330.0 288.0 3 30 27 3 [[712, 970]] 1.0 2gs7 TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3GT8A P00533 700 1014 1210.0 ANP:60002 ATPlike Inactive DFGin 4.9934 16.3899 BLBtrans -126.87, 160.91 79.29, 15.25 -62.33, 143.15 149.45, 88.24 77.42, 3.92 out-out out 14.0883 Saltbr-out 14.9565 HRD-in -72.04, -61.33 88.51, -0.69 out-out-none SNCoon out-none ActLoopNT-out 6.5602 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 19.46 APE8-rot-na 342.23 APE67-dihe-in -68.79, -19.52 -40.63, -50.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V948R None None XRAY 2.955 0.219 0.275 A 330.0 300.0 15 30 15 15 [[712, 970]] 1.0 3gt8 TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3GT8B P00533 701 1007 1210.0 ANP:60001 ATPlike Inactive DFGin 5.2466 16.1025 BLBtrans -113.7, -174.86 52.25, 31.77 -67.43, 143.58 157.41, 75.54 60.22, 2.12 out-out out 13.3548 Saltbr-out 13.7165 HRD-in -65.21, -59.58 85.13, -27.25 out-out-none SNCoon out-none ActLoopNT-out 6.3836 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 3.18 APE8-rot-na 352.22 APE67-dihe-in -64.44, -9.93 -42.76, -50.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V948R None None XRAY 2.955 0.219 0.275 B 330.0 292.0 15 30 15 15 [[712, 970]] 1.0 3gt8 TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3GT8C P00533 699 1007 1210.0 ANP:60003 ATPlike Inactive DFGin 4.7311 16.0424 BLBtrans -111.03, -172.93 50.46, 27.13 -68.53, 136.25 146.08, 72.89 59.13, 17.74 out-out out 14.315 Saltbr-out 13.2834 HRD-in -57.94, -53.03 83.1, -30.64 out-out-none SNCoon out-none ActLoopNT-out 6.5164 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 131.04 APE8-dihe-in -73.71, 55.48 APE8-rot-na 345.44 APE67-dihe-in -72.77, 4.68 -41.49, -48.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.982 V948R None None XRAY 2.955 0.219 0.275 C 330.0 296.0 13 30 17 13 [[712, 970]] 1.0 3gt8 TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3GT8D P00533 701 1010 1210.0 ANP:60004 ATPlike Inactive DFGin 5.2361 16.3468 BLBtrans -129.98, 167.43 62.52, 32.14 -70.14, 140.82 152.86, 71.47 77.5, -20.57 out-out out 14.0591 Saltbr-out 13.5142 HRD-in -61.66, -53.51 87.8, -16.84 out-out-none SNCoon out-none ActLoopNT-out 6.7968 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 30.46 APE8-rot-na 344.36 APE67-dihe-in -63.75, 2.23 -59.31, -42.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V948R None None XRAY 2.955 0.219 0.275 D 330.0 295.0 15 30 15 15 [[712, 970]] 1.0 3gt8 TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CNOA P00533 700 1015 1210.0 ANP:61001 ATPlike Inactive DFGin 5.5039 16.1608 BLBtrans -118.04, 171.2 68.22, 21.52 -56.79, 132.54 171.14, 68.18 99.53, -19.86 out-out out 13.7182 Saltbr-out 12.9439 HRD-in -82.44, -48.26 77.49, -9.43 out-out-out SNCooo out-out ActLoopNT-out 6.3415 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 122.24 APE9-dihe-in -77.97, 140.5 APE8-dihe-in -80.47, 64.47 APE8-rot-na 27.48 APE67-dihe-in -78.06, -5.87 -50.51, -36.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.5884 APE9-dist-out 8.271 V948R None None XRAY 1.55 0.176 0.203 A 330.0 300.0 16 30 19 11 [[712, 970]] 1.0 5cno TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CNNB P00533 700 1014 1210.0 ANP:61101 ATPlike Inactive DFGin 5.5714 16.3897 BLBtrans -117.7, 174.34 67.16, 24.17 -60.91, 135.45 168.23, 72.49 97.23, -21.68 out-out out 13.7881 Saltbr-out 12.7591 HRD-in -80.25, -51.08 77.81, -11.48 out-out-out SNCooo out-out ActLoopNT-out 6.3744 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -75.45 APE9-dihe-in -63.67, 125.67 APE8-dihe-in -78.86, 65.92 APE8-rot-na 30.44 APE67-dihe-in -73.57, -5.24 -51.98, -40.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.0859 APE9-dist-out 8.2793 I706Q None None XRAY 1.9 0.183 0.211 B 350.0 304.0 11 30 19 11 [[712, 970]] 1.0 5cnn TYR_EGFR_HUMAN TYR 1.3e-87 299.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5X2AB P00533 700 1022 1210.0 7XO:1105,ANP:1106 Type1,ATPlike Inactive DFGin 5.521 16.3794 BLBtrans -118.08, 178.13 68.28, 22.21 -63.57, 132.1 161.37, 67.84 99.95, -15.3 out-out out 13.8924 Saltbr-out 13.5052 HRD-in -67.87, -49.57 81.65, -13.01 out-out-out SNCooo out-out ActLoopNT-out 6.3644 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -63.35, -22.61 APE9-dihe-in -95.03, 108.56 APE8-dihe-in -83.98, 72.85 APE8-rot-na 21.28 APE67-dihe-in -71.39, -9.89 -59.75, -39.3 APE12-dist-na 15.7264 APE11-dist-na 13.2452 APE10-dist-na 9.2736 APE9-dist-in 7.5679 T790M,V948R None None XRAY 1.85 0.176 0.219 B 331.0 322.0 0 30 30 0 [[712, 970]] 1.0 5x2a TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5X2AA P00533 700 1011 1210.0 7XO:1107,ANP:1108 Type1,Allosteric Inactive DFGin 5.5648 16.303 BLBtrans -120.52, 179.71 70.51, 14.21 -61.87, 136.6 165.52, 70.66 90.66, -18.93 out-out out 13.7777 Saltbr-out 13.1042 HRD-in -79.48, -46.8 73.07, -8.08 out-out-none SNCoon out-none ActLoopNT-out 6.728 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 152.51 APE8-dihe-in -84.48, 76.35 APE8-rot-na 26.1 APE67-dihe-in -71.21, -12.48 -60.14, -38.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.7618 T790M,V948R None None XRAY 1.85 0.176 0.219 A 331.0 297.0 13 30 17 13 [[712, 970]] 1.0 5x2a TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EPHA2 EPHA2_HUMAN 1MQBA P29317 605 887 976.0 ANP:1000 ATPlike Inactive DFGin 5.7122 14.9239 BLAminus -127.53, -172.03 57.53, 74.63 -109.94, 122.74 306.64, 100.38 176.53, 104.78 in-out in 8.4647 Saltbr-out 5.6749 HRD-in -62.1, -45.48 77.42, -17.66 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -37.06 APE9-dihe-in -88.14, 119.95 APE8-dihe-in -73.81, 144.85 APE8-rot-na 33.04 APE67-dihe-in -82.72, 0.0 -54.3, -43.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.5534 APE9-dist-in 5.5976 None None None XRAY 2.3 0.237 0.288 A 333.0 263.0 20 31 14 17 [[613, 873]] 1.0 1mqb TYR_EPHA2_HUMAN TYR 7.4e-108 365.7 2.0 261.0 260.0 756 757 758 760 762 646 663 667 736 738 737 739.0 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 1MQBB P29317 602 883 976.0 ANP:1001 ATPlike None DFGin 5.6905 14.8889 BLAminus -139.65, -173.77 51.28, 81.33 -92.67, 10.65 292.99, 95.58 -41.77, -44.65 in-in in 8.2733 Saltbr-in 2.6399 HRD-in -72.65, -50.06 79.19, -16.04 in-in-none SNCiin in-none ActLoopNT-in 2.9923 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -50.3 APE9-dihe-in -134.32, 148.66 APE8-dihe-in -83.15, 83.63 APE8-rot-na 31.61 APE67-dihe-in -80.07, -2.61 -53.54, -47.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.3278 APE9-dist-in 6.6333 None None None XRAY 2.3 0.237 0.288 B 333.0 265.0 17 31 18 13 [[613, 873]] 1.0 1mqb TYR_EPHA2_HUMAN TYR 7.4e-108 365.7 2.0 261.0 260.0 756 757 758 760 762 646 663 667 736 738 737 739.0 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 5I9WA P29317 605 895 976.0 ANP:1001 ATPlike Inactive DFGin 6.2443 15.2815 BLBminus -125.95, -162.36 67.3, 57.63 -98.89, 156.85 294.37, 103.89 164.47, 175.48 in-in in 8.3467 Saltbr-in 2.7642 HRD-in -75.49, -48.49 78.15, -15.84 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.31 APE8-dihe-in -84.75, 145.17 APE8-rot-na 35.12 APE67-dihe-in -78.8, -3.01 -55.81, -43.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.3423 None None None XRAY 1.359 0.17 0.18 A 306.0 267.0 24 31 13 18 [[613, 873]] 1.0 5i9w TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2.0 261.0 260.0 756 757 758 760 762 646 663 667 736 738 737 739.0 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA3 EPHA3_HUMAN 2QOCA P29320 613 906 983.0 ANP:949 ATPlike Inactive DFGin 4.9949 15.4446 BLAminus -141.69, -171.73 58.63, 84.29 -97.26, 21.84 297.12, 103.61 -61.69, -31.71 in-out in 9.4946 Saltbr-out 6.0476 HRD-in -71.05, -48.03 74.01, -8.74 out-in-none SNCoin in-none ActLoopNT-in 3.023 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 135.66 APE9-dihe-in -81.0, 137.87 APE8-dihe-in -77.44, 99.9 APE8-rot-na 34.81 APE67-dihe-in -63.09, -22.76 -54.0, -44.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.2139 APE9-dist-in 5.5143 None None None XRAY 1.25 0.17 0.186 A 344.0 283.0 11 31 20 11 [[621, 880]] 1.0 2qoc TYR_EPHA3_HUMAN TYR 8.4e-111 375.4 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 3FXXA P29320 606 904 983.0 ANP:992 ATPlike Inactive DFGin 4.9 15.171 BLAminus -132.57, -176.13 56.24, 78.37 -91.43, 22.66 298.54, 96.01 -59.15, -30.35 in-out in 9.3764 Saltbr-out 4.2542 HRD-in -72.67, -46.91 76.32, -4.64 out-in-in SNCoii in-in ActLoopNT-in 2.804 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.39, 147.18 APE9-dihe-in -116.01, 151.61 APE8-dihe-in -77.44, 77.25 APE8-rot-na 30.85 APE67-dihe-in -60.25, -20.23 -50.19, -49.06 APE12-dist-na 999.0 APE11-dist-na 8.9995 APE10-dist-na 10.1833 APE9-dist-in 6.2382 A608T None None XRAY 1.7 0.168 0.194 A 371.0 288.0 9 31 22 9 [[621, 880]] 1.0 3fxx TYR_EPHA3_HUMAN TYR 1.1e-110 375.1 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2QO7A P29320 595 904 983.0 ANP:1000 ATPlike Inactive DFGin 5.4809 15.5563 BLAminus -130.76, -168.32 68.6, 58.57 -92.37, 46.9 297.61, 96.94 -87.84, 999.0 in-out in 8.4003 Saltbr-out 4.3475 HRD-in -73.41, -45.48 73.79, -12.75 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 85.99 APE8-rot-na 29.77 APE67-dihe-in -61.7, -25.84 -53.26, -41.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None PTR701 PTR701 XRAY 1.605 0.186 0.224 A 373.0 279.0 20 31 11 20 [[621, 880]] 1.0 2qo7 TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2QO9A P29320 608 904 983.0 ANP:948 ATPlike Inactive DFGin 5.2052 15.375 BLAminus -133.34, -177.89 59.05, 80.14 -92.65, 15.74 295.85, 100.25 -55.83, -40.55 in-out in 9.2347 Saltbr-out 4.2304 HRD-in -71.62, -45.86 73.18, -10.67 out-in-out SNCoio in-out ActLoopNT-in 2.9965 ActLoopCT-out TYR APEdihe_noiai APEdist_aaai APE10-dihe-none 999.0, 105.46 APE9-dihe-out 41.85, 78.2 APE8-dihe-in -71.02, 94.17 APE8-rot-na 29.94 APE67-dihe-in -61.69, -23.23 -54.76, -43.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.1675 APE9-dist-in 5.8543 None None None XRAY 1.55 0.183 0.211 A 373.0 277.0 13 31 18 13 [[621, 880]] 1.0 2qo9 TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2QOQA P29320 595 906 983.0 ANP:948 ATPlike None DFGin 5.3598 15.5746 BLAminus -132.4, -170.9 64.35, 72.55 -105.5, 56.47 301.01, 91.74 -101.2, 999.0 in-in in 8.6353 Saltbr-in 2.7272 HRD-in -73.3, -48.21 73.66, -6.72 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 133.24 APE9-dihe-in -154.49, 111.52 APE8-dihe-in -76.14, 92.58 APE8-rot-na 29.51 APE67-dihe-in -62.32, -22.8 -60.77, -45.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.7427 None PTR701 PTR701 XRAY 1.6 0.19 0.219 A 373.0 285.0 18 31 13 18 [[621, 880]] 1.0 2qoq TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR ERBB3 ERBB3_HUMAN 3KEXA P21860 698 994 1342.0 ANP:60001 ATPlike Pseudo DFGin 5.6601 12.692 BLBplus -136.97, 172.9 58.22, 40.12 -96.04, 155.03 48.2, 92.31 69.55, -19.76 out-na out 15.2354 Saltbr-na 999.0 HRD-in -90.16, -54.52 74.78, -7.72 na-out-out SNCaoo out-out ActLoopNT-out 6.7279 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.57 APE8-dihe-out -99.2, 24.49 APE8-rot-na 333.43 APE67-dihe-in -74.24, 11.38 -68.56, -18.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.7737 None None None XRAY 2.797 0.243 0.283 A 325.0 292.0 5 30 25 5 [[709, 967]] 1.0 3kex TYR_ERBB3_HUMAN TYR 6e-80 274.2 2.0 260.0 259.0 851 852 853 855 857 742 759 763 831 833 832 834.0 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 3KEXB P21860 698 988 1342.0 ANP:60002 ATPlike Pseudo DFGin 5.652 12.6727 BLBplus -137.46, 172.26 58.51, 39.18 -94.14, 155.27 47.87, 93.32 68.94, -19.33 out-na out 15.2321 Saltbr-na 999.0 HRD-in -90.89, -54.23 74.6, -7.22 na-out-out SNCaoo out-out ActLoopNT-out 6.7271 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 145.38 APE8-dihe-out -51.8, -10.63 APE8-rot-na 330.98 APE67-dihe-in -73.43, 11.3 -67.12, -27.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.2152 None None None XRAY 2.797 0.243 0.283 B 325.0 283.0 7 30 23 7 [[709, 967]] 1.0 3kex TYR_ERBB3_HUMAN TYR 6e-80 274.2 2.0 260.0 259.0 851 852 853 855 857 742 759 763 831 833 832 834.0 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIWA P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.6652 12.9195 BLBplus -124.68, 170.7 61.91, 32.93 -86.72, 138.2 53.99, 90.7 80.0, -6.46 out-na out 15.1205 Saltbr-na 999.0 HRD-in -76.0, -53.69 67.87, 2.11 na-out-none SNCaon out-none ActLoopNT-out 6.6323 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -2.58 APE8-rot-na 28.66 APE67-dihe-in -88.2, -5.19 -70.28, -23.24 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 3.1 0.233 0.287 A 326.0 269.0 12 30 18 12 [[709, 967]] 1.0 4riw TYR_ERBB3_HUMAN TYR 6.1e-80 274.2 2.0 260.0 259.0 851 852 853 855 857 742 759 763 831 833 832 834.0 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIWC P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.6184 13.0319 BLBplus -125.06, 170.64 62.1, 33.09 -86.97, 138.33 54.47, 90.5 80.01, -6.38 out-na out 15.4904 Saltbr-na 999.0 HRD-in -75.9, -53.21 67.39, 0.69 na-out-out SNCaoo out-out ActLoopNT-out 6.3934 ActLoopCT-out TYR APEdihe_oioai APEdist_aaao APE10-dihe-out -113.39, 20.05 APE9-dihe-in -68.39, 127.6 APE8-dihe-out -63.99, -4.42 APE8-rot-na 333.17 APE67-dihe-in -86.76, -6.22 -71.15, -22.24 APE12-dist-na 21.5437 APE11-dist-na 20.4194 APE10-dist-na 15.4077 APE9-dist-out 10.083 None None None XRAY 3.1 0.233 0.287 C 326.0 275.0 6 30 30 0 [[709, 967]] 1.0 4riw TYR_ERBB3_HUMAN TYR 6.1e-80 274.2 2.0 260.0 259.0 851 852 853 855 857 742 759 763 831 833 832 834.0 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 3LMGA P21860 699 978 1342.0 ANP:60301 ATPlike Pseudo DFGin 5.7284 12.9636 BLBplus -117.83, 170.87 63.58, 24.7 -69.26, 132.03 43.93, 98.75 70.87, 7.13 out-na out 15.5784 Saltbr-na 999.0 HRD-in -64.67, -52.37 74.61, 1.05 na-out-out SNCaoo out-out ActLoopNT-out 6.623 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 104.53 APE8-dihe-out -45.34, -17.97 APE8-rot-na 330.0 APE67-dihe-in -71.66, -7.63 -57.32, -31.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.4636 None None None XRAY 2.8 0.255 0.285 A 344.0 268.0 12 30 21 9 [[709, 967]] 1.0 3lmg TYR_ERBB3_HUMAN TYR 7.3e-80 274.0 2.0 260.0 259.0 851 852 853 855 857 742 759 763 831 833 832 834.0 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 3LMGB P21860 699 978 1342.0 ANP:60301 ATPlike Pseudo DFGin 5.789 12.8435 BLBplus -113.43, 165.54 66.13, 22.95 -73.3, 147.22 48.63, 94.29 81.01, -18.45 out-na out 15.3813 Saltbr-na 999.0 HRD-in -77.74, -52.9 74.69, -13.1 na-out-none SNCaon out-none ActLoopNT-out 6.8052 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -22.84 APE8-rot-na 330.0 APE67-dihe-in -67.55, -12.53 -55.83, -37.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.255 0.285 B 344.0 268.0 12 30 21 9 [[709, 967]] 1.0 3lmg TYR_ERBB3_HUMAN TYR 7.3e-80 274.0 2.0 260.0 259.0 851 852 853 855 857 742 759 763 831 833 832 834.0 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIYA P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.753 12.8685 BLBplus -123.9, 168.71 62.98, 31.45 -82.39, 142.59 52.35, 86.17 78.8, -6.78 out-na out 15.0438 Saltbr-na 999.0 HRD-in -75.26, -54.75 69.16, 2.85 na-out-none SNCaon out-none ActLoopNT-out 6.4496 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -9.22 APE8-rot-na 31.12 APE67-dihe-in -85.56, -1.17 -67.69, -25.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 E928G None None XRAY 2.981 0.221 0.267 A 326.0 269.0 12 30 18 12 [[709, 967]] 1.0 4riy TYR_ERBB3_HUMAN TYR 1.3e-79 273.1 2.0 260.0 259.0 851 852 853 855 857 742 759 763 831 833 832 834.0 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIYC P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.5774 13.185 BLBplus -124.39, 168.66 63.11, 31.61 -82.48, 141.95 52.91, 86.81 78.36, -7.08 out-na out 15.6054 Saltbr-na 999.0 HRD-in -74.67, -54.96 68.56, 2.02 na-out-out SNCaoo out-out ActLoopNT-out 6.5253 ActLoopCT-out TYR APEdihe_oioai APEdist_aaao APE10-dihe-out -99.97, 8.97 APE9-dihe-in -62.65, 132.93 APE8-dihe-out -66.25, -9.79 APE8-rot-na 341.07 APE67-dihe-in -85.25, -1.58 -67.21, -25.34 APE12-dist-na 22.2853 APE11-dist-na 20.5354 APE10-dist-na 15.6134 APE9-dist-out 10.1634 E928G None None XRAY 2.981 0.221 0.267 C 326.0 275.0 6 30 30 0 [[709, 967]] 1.0 4riy TYR_ERBB3_HUMAN TYR 1.3e-79 273.1 2.0 260.0 259.0 851 852 853 855 857 742 759 763 831 833 832 834.0 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIXA P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.5341 12.788 BLBplus -125.2, 170.11 60.89, 28.84 -82.14, 140.77 56.51, 90.87 77.72, -6.25 out-na out 15.0398 Saltbr-na 999.0 HRD-in -77.1, -53.12 66.52, 0.72 na-out-none SNCaon out-none ActLoopNT-out 6.5125 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -5.5 APE8-rot-na 30.9 APE67-dihe-in -82.84, -10.3 -67.07, -25.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q809R None None XRAY 3.1 0.21 0.258 A 326.0 269.0 12 30 18 12 [[709, 967]] 1.0 4rix TYR_ERBB3_HUMAN TYR 9.7e-80 273.5 2.0 260.0 259.0 851 852 853 855 857 742 759 763 831 833 832 834.0 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIXC P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.5566 13.1159 BLBplus -126.64, 170.72 61.2, 28.92 -82.69, 140.73 56.76, 91.32 77.44, -6.2 out-na out 15.4732 Saltbr-na 999.0 HRD-in -76.48, -52.61 66.58, -0.13 na-out-out SNCaoo out-out ActLoopNT-out 6.3725 ActLoopCT-out TYR APEdihe_oioai APEdist_aaao APE10-dihe-out -112.15, 5.58 APE9-dihe-in -58.87, 135.06 APE8-dihe-out -71.85, -6.39 APE8-rot-na 348.17 APE67-dihe-in -82.4, -10.58 -67.81, -25.66 APE12-dist-na 21.6583 APE11-dist-na 20.6117 APE10-dist-na 15.6054 APE9-dist-out 9.9687 Q809R None None XRAY 3.1 0.21 0.258 C 326.0 275.0 6 30 30 0 [[709, 967]] 1.0 4rix TYR_ERBB3_HUMAN TYR 9.7e-80 273.5 2.0 260.0 259.0 851 852 853 855 857 742 759 763 831 833 832 834.0 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR FGFR2 FGFR2_HUMAN 5UGLA P21802 468 764 821.0 ANP:802 ATPlike Inactive DFGin 6.7324 14.4645 BLAminus -137.83, -175.53 60.75, 66.42 -85.03, 17.04 287.79, 92.86 -66.15, -23.38 in-in in 7.6692 Saltbr-in 2.7606 HRD-in -76.2, -48.26 75.23, -6.81 in-in-out SNCiio in-out ActLoopNT-in 2.8649 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.99, 26.82 APE9-dihe-in -107.7, 135.68 APE8-dihe-in -52.5, 118.32 APE8-rot-na 330.79 APE67-dihe-in -70.92, -8.04 -59.23, -38.34 APE12-dist-na 14.8866 APE11-dist-na 10.816 APE10-dist-na 7.6416 APE9-dist-in 5.1026 D650V None None XRAY 1.861 0.221 0.258 A 324.0 285.0 12 30 30 0 [[481, 759]] 1.0 5ugl TYR_FGFR2_HUMAN TYR 4.3e-104 353.4 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5UGLB P21802 467 764 821.0 ANP:802 ATPlike Inactive DFGin 6.7377 14.4797 BLAminus -137.57, -172.18 55.78, 69.64 -87.75, 15.81 286.63, 92.96 -64.54, -22.36 in-in in 7.6528 Saltbr-in 2.7177 HRD-in -74.83, -48.38 75.49, -7.57 in-in-out SNCiio in-out ActLoopNT-in 2.8681 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.07, 25.73 APE9-dihe-in -107.84, 135.51 APE8-dihe-in -51.06, 118.2 APE8-rot-na 329.13 APE67-dihe-in -71.28, -8.69 -57.7, -39.45 APE12-dist-na 999.0 APE11-dist-na 10.8311 APE10-dist-na 7.6693 APE9-dist-in 5.0837 D650V None None XRAY 1.861 0.221 0.258 B 324.0 271.0 27 30 19 11 [[481, 759]] 1.0 5ugl TYR_FGFR2_HUMAN TYR 4.3e-104 353.4 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR HCK HCK_HUMAN 1AD5A P08631 79 526 526.0 ANP:60001 ATPlike Inactive DFGin 6.8776 13.5562 BLAminus -111.54, 157.75 55.86, 95.53 -99.86, -56.89 321.06, 144.41 -91.88, 132.97 out-out out 13.5916 Saltbr-out 14.4523 HRD-out -92.59, 96.14 -56.64, -30.38 out-out-out SNCooo out-out ActLoopNT-out 11.4135 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -107.24, 53.46 APE9-dihe-in -96.28, 143.43 APE8-dihe-out -62.47, 38.68 APE8-rot-na 35.25 APE67-dihe-in -59.4, -26.12 -40.35, -46.47 APE12-dist-na 11.6595 APE11-dist-na 16.6044 APE10-dist-na 16.1334 APE9-dist-out 10.4142 None PTR522 PTR522 XRAY 2.6 0.239 0.307 A 438.0 438.0 0 29 29 0 [[262, 513]] 1.0 1ad5 TYR_HCK_HUMAN TYR 1.4e-88 303.1 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 1AD5B P08631 79 526 526.0 ANP:60532 ATPlike Inactive DFGin 6.635 13.5293 BLAminus -108.53, 152.83 57.68, 95.37 -100.87, -57.78 321.85, 133.69 -88.86, 132.45 out-out out 13.5911 Saltbr-out 14.3339 HRD-out -97.62, 96.0 -55.31, -32.54 out-out-out SNCooo out-out ActLoopNT-out 11.4801 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.78, 54.95 APE9-dihe-in -97.18, 143.16 APE8-dihe-out -68.08, 36.88 APE8-rot-na 32.16 APE67-dihe-in -59.62, -27.02 -36.62, -45.49 APE12-dist-na 11.6841 APE11-dist-na 16.5851 APE10-dist-na 16.2062 APE9-dist-out 10.5337 None PTR522 PTR522 XRAY 2.6 0.239 0.307 B 438.0 438.0 0 29 29 0 [[262, 513]] 1.0 1ad5 TYR_HCK_HUMAN TYR 1.4e-88 303.1 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR IGF1R IGF1R_HUMAN 1JQHA P08069 984 1286 1367.0 ANP:301 ATPlike Inactive DFGin 5.6898 16.5691 None -66.7, 163.88 -59.45, 151.32 -140.18, 178.07 43.94, 89.38 -106.76, 173.06 in-out in 9.9768 Saltbr-out 6.0561 HRD-in -50.88, -56.96 74.77, -3.78 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -84.24, 106.81 APE9-dihe-in -58.88, 134.76 APE8-dihe-in -78.96, 121.64 APE8-rot-na 37.96 APE67-dihe-in -60.45, -7.73 -52.46, -43.95 APE12-dist-na 7.1567 APE11-dist-na 11.2997 APE10-dist-na 15.5969 APE9-dist-in 5.8 E979G,Y980S None None XRAY 2.1 0.195 0.219 A 308.0 291.0 12 30 23 7 [[999, 1268]] 1.0 1jqh TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 1JQHB P08069 984 1286 1367.0 ANP:302 ATPlike Inactive DFGin 5.6866 16.5538 None -65.78, 164.4 -59.98, 151.89 -140.81, 178.2 43.68, 89.42 -109.69, -174.77 in-out in 9.9884 Saltbr-out 6.0195 HRD-in -51.69, -56.66 74.32, -2.97 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.6, 107.67 APE9-dihe-in -58.75, 135.36 APE8-dihe-in -79.54, 122.52 APE8-rot-na 37.69 APE67-dihe-in -59.25, -7.46 -52.18, -45.28 APE12-dist-na 6.8166 APE11-dist-na 10.9316 APE10-dist-na 15.2162 APE9-dist-in 5.768 E979G,Y980S None None XRAY 2.1 0.195 0.219 B 308.0 287.0 16 30 23 7 [[999, 1268]] 1.0 1jqh TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 1JQHC P08069 984 1286 1367.0 ANP:303 ATPlike Inactive DFGin 5.6976 16.5582 None -65.47, 162.73 -58.75, 151.62 -140.8, 179.03 43.87, 88.98 -110.24, -177.72 in-out in 9.9987 Saltbr-out 6.0347 HRD-in -53.2, -57.0 74.59, -2.63 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.9, 107.89 APE9-dihe-in -58.88, 134.76 APE8-dihe-in -79.04, 122.75 APE8-rot-na 38.27 APE67-dihe-in -60.34, -8.42 -53.61, -43.61 APE12-dist-na 6.9265 APE11-dist-na 10.9862 APE10-dist-na 15.2452 APE9-dist-in 5.7735 E979G,Y980S None None XRAY 2.1 0.195 0.219 C 308.0 291.0 12 30 23 7 [[999, 1268]] 1.0 1jqh TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR INSR INSR_HUMAN 1IR3A P06213 1008 1310 1382.0 ANP:60300 ATPlike Inactive DFGin 6.1283 14.366 BLAminus -133.72, -168.17 47.48, 85.02 -100.33, 24.62 303.32, 104.39 -58.78, -39.74 in-out in 8.9234 Saltbr-out 4.3926 HRD-in -68.06, -49.87 71.52, -7.17 out-in-in SNCoii in-in ActLoopNT-in 2.9018 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.98, 116.19 APE9-dihe-in -117.81, 138.98 APE8-dihe-in -77.82, 71.42 APE8-rot-na 34.55 APE67-dihe-in -66.85, -13.55 -40.74, -47.32 APE12-dist-na 14.5115 APE11-dist-na 10.4265 APE10-dist-na 9.7642 APE9-dist-in 6.771 C1008S,Y1011F PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 1.9 0.194 0.226 A 306.0 303.0 0 30 30 0 [[1023, 1292]] 1.0 1ir3 TYR_INSR_HUMAN TYR 1.4e-96 328.7 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR LCK LCK_HUMAN 1QPCA P06239 231 502 509.0 ANP:904 ATPlike Active DFGin 6.6104 14.4162 BLAminus -133.73, 179.02 58.4, 83.48 -97.79, 21.23 295.19, 99.8 -60.65, -35.99 in-in in 8.7018 Saltbr-in 3.0957 HRD-in -103.01, -49.32 74.3, -4.36 in-in-in SNCiii in-in ActLoopNT-in 2.9208 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.97, 142.08 APE9-dihe-in -126.79, 156.19 APE8-dihe-in -63.13, 117.89 APE8-rot-na 333.56 APE67-dihe-in -65.85, -20.96 -57.94, -43.39 APE12-dist-na 14.8556 APE11-dist-na 10.0047 APE10-dist-na 12.788 APE9-dist-in 6.7844 None PTR394 PTR394 XRAY 1.6 0.2 0.23 A 279.0 272.0 0 29 29 0 [[245, 496]] 1.0 1qpc TYR_LCK_HUMAN TYR 1.4e-94 322.2 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
TYR MERTK MERTK_HUMAN 2P0CA Q12866 575 861 999.0 ANP:1 ATPlike Inactive DFGin 5.9242 13.1365 BLBplus -137.27, 178.6 60.37, 23.32 -81.61, 167.49 49.71, 91.11 85.65, -47.4 out-none out 13.6493 Saltbr-none 999.0 HRD-in -80.53, -55.62 75.56, -3.56 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 51.71 APE8-rot-na 32.28 APE67-dihe-in -80.87, -2.88 -33.63, -45.94 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.208 0.274 A 313.0 249.0 38 30 12 18 [[587, 856]] 1.0 2p0c TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 2P0CB Q12866 575 861 999.0 ANP:2 ATPlike Inactive DFGin 6.0339 13.3315 BLBplus -140.6, 176.88 63.43, 26.39 -92.68, 153.87 48.18, 81.79 87.34, -0.94 out-none out 13.9733 Saltbr-none 999.0 HRD-in -83.37, -59.67 75.95, 2.32 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.74 APE8-rot-na 27.11 APE67-dihe-in -70.68, -3.16 -43.98, -45.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.208 0.274 B 313.0 248.0 39 30 12 18 [[587, 856]] 1.0 2p0c TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MST1R RON_HUMAN 3PLSA Q04912 1060 1357 1400.0 ANP:1358 ATPlike Inactive DFGin 6.2964 13.4362 BLBplus -158.57, 169.48 54.59, 28.32 -75.35, 163.89 46.83, 88.44 77.37, 8.52 out-out out 14.5017 Saltbr-out 15.6805 HRD-in -64.04, -56.3 78.09, -13.1 out-out-out SNCooo out-out ActLoopNT-out 7.3962 ActLoopCT-out TYR APEdihe_oioai APEdist_aaao APE10-dihe-out -133.31, 27.58 APE9-dihe-in -79.04, 151.37 APE8-dihe-out -60.01, -26.4 APE8-rot-na 344.59 APE67-dihe-in -77.79, -6.02 -43.7, -39.07 APE12-dist-na 21.5297 APE11-dist-na 22.4916 APE10-dist-na 18.0334 APE9-dist-out 10.6231 M1254T None None XRAY 2.24 0.235 0.29 A 298.0 298.0 0 32 32 0 [[1082, 1343]] 1.0 3pls TYR_MST1R_HUMAN TYR 3.8e-88 301.1 4.0 260.0 257.0 1225 1226 1227 1229 1231 1114 1131 1135 1205 1207 1206 1208.0 1269 1257 1252 1251 1250 1249 1248 1247 1246 1162 Macrophage-stimulating protein receptor
TYR MST1R RON_HUMAN 8ZKDA Q04912 1060 1357 1400.0 ANP:1401 ATPlike Inactive DFGin 5.9634 13.4449 BLBplus -136.42, 163.89 75.82, 17.06 -71.65, 165.79 57.65, 82.07 74.72, 11.98 out-out out 14.7199 Saltbr-out 14.9554 HRD-in -65.95, -60.68 80.92, -14.74 out-out-out SNCooo out-out ActLoopNT-out 7.373 ActLoopCT-out TYR APEdihe_iooai APEdist_aaao APE10-dihe-in -84.37, 161.73 APE9-dihe-out -52.23, -44.7 APE8-dihe-out -56.31, -27.37 APE8-rot-na 334.62 APE67-dihe-in -83.51, -2.98 -41.89, -46.09 APE12-dist-na 22.0591 APE11-dist-na 19.0322 APE10-dist-na 14.2218 APE9-dist-out 10.029 None None None XRAY 2.05 0.18 0.231 A 298.0 298.0 0 32 32 0 [[1082, 1343]] 1.0 8zkd TYR_MST1R_HUMAN TYR 3.8e-88 301.1 4.0 260.0 257.0 1225 1226 1227 1229 1231 1114 1131 1135 1205 1207 1206 1208.0 1269 1257 1252 1251 1250 1249 1248 1247 1246 1162 Macrophage-stimulating protein receptor
TYR SRC SRC_HUMAN 2SRCA P12931 87 536 536.0 ANP:60001 ATPlike Inactive DFGin 5.9228 13.5972 BLBplus -121.59, 173.63 47.36, 36.7 -81.78, 143.05 40.4, 84.17 86.45, -40.21 out-out out 14.1179 Saltbr-out 13.9285 HRD-in -73.32, -58.33 81.61, -7.89 out-out-out SNCooo out-out ActLoopNT-out 7.5408 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.49, -13.33 APE9-dihe-in -91.46, 129.38 APE8-dihe-in -79.29, 62.74 APE8-rot-na 33.55 APE67-dihe-in -68.18, -15.62 -55.52, -29.75 APE12-dist-na 17.3787 APE11-dist-na 18.7431 APE10-dist-na 13.4547 APE9-dist-out 8.7458 None PTR530 PTR530 XRAY 1.5 0.226 0.281 A 452.0 450.0 0 29 29 0 [[270, 521]] 1.0 2src TYR_SRC_HUMAN TYR 6.7e-94 320.2 1.0 260.0 260.0 406 407 408 410 412 298 313 317 386 388 387 389.0 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SYK KSYK_HUMAN 4FL1A P43405 363 635 635.0 ANP:701 ATPlike Active DFGin 6.6692 15.0632 BLAminus -122.6, -175.53 56.16, 78.38 -92.62, 24.67 287.04, 93.75 -57.67, -38.36 in-in in 8.0588 Saltbr-in 2.6833 HRD-in -76.27, -50.57 71.77, 3.28 in-in-in SNCiii in-in ActLoopNT-in 2.9759 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.55, 85.11 APE9-dihe-in -99.28, 138.37 APE8-dihe-in -79.64, 69.72 APE8-rot-na 29.68 APE67-dihe-in -60.65, -16.95 -44.16, -41.68 APE12-dist-na 13.8161 APE11-dist-na 10.806 APE10-dist-na 10.4124 APE9-dist-in 7.1318 None None None XRAY 1.79 0.197 0.225 A 291.0 268.0 5 31 31 0 [[370, 628]] 1.0 4fl1 TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4FL3A P43405 9 635 635.0 ANP:701 ATPlike Inactive DFGin 5.2707 12.4112 BLBplus -116.27, 169.06 58.02, 22.77 -60.26, 128.95 39.87, 90.8 70.36, 3.28 out-out out 13.3472 Saltbr-out 12.957 HRD-in -71.66, -54.51 80.39, -19.8 out-out-none SNCoon out-none ActLoopNT-out 7.0299 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 2.25 APE8-rot-na 29.04 APE67-dihe-in -63.72, -20.72 -59.66, -31.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y348F,Y352F None None XRAY 1.9 0.18 0.208 A 635.0 538.0 13 31 18 13 [[370, 628]] 1.0 4fl3 TYR_SYK_HUMAN TYR 5.1e-89 304.2 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4FL2A P43405 9 635 635.0 ANP:702 ATPlike Inactive DFGin 5.4285 12.3278 BLBplus -115.2, 163.41 55.5, 31.26 -66.72, 128.2 35.56, 90.39 65.72, 13.6 out-out out 13.4906 Saltbr-out 13.2027 HRD-in -70.05, -49.77 75.03, -15.27 out-out-out SNCooo out-out ActLoopNT-out 7.1942 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -115.16, 144.55 APE9-dihe-in -104.91, 94.8 APE8-dihe-out -50.62, -30.17 APE8-rot-na 333.32 APE67-dihe-in -61.99, -18.29 -62.08, -21.97 APE12-dist-na 15.5558 APE11-dist-na 19.2065 APE10-dist-na 15.7365 APE9-dist-out 11.5275 None None None XRAY 2.19 0.184 0.228 A 636.0 555.0 0 31 31 0 [[370, 628]] 1.0 4fl2 TYR_SYK_HUMAN TYR 5.1e-89 304.2 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR ZAP70 ZAP70_HUMAN 2OZOA P43403 2 606 619.0 ANP:60615 ATPlike Inactive DFGin 5.8971 12.8886 BLAplus -127.72, 179.11 41.99, 48.0 -92.67, 86.43 47.29, 92.46 138.54, -47.19 out-out out 14.1822 Saltbr-out 12.4812 HRD-in -87.29, -57.15 80.94, -19.73 out-out-out SNCooo out-out ActLoopNT-out 7.5295 ActLoopCT-out TYR APEdihe_nnnao APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 93.52 APE8-rot-na 331.14 APE67-dihe-out -88.9, 16.07 -148.01, 51.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y315F,Y319F,D461N None None XRAY 2.6 0.26 0.29 A 613.0 538.0 14 31 17 14 [[338, 595]] 1.0 2ozo TYR_ZAP70_HUMAN TYR 8.5e-89 303.4 6.0 259.0 254.0 478 479 480 482 484 369 386 390 458 460 459 461.0 521 509 504 503 502 501 500 499 498 415 Tyrosine-protein kinase ZAP-70
TYR ZAP70 ZAP70_HUMAN 4K2RA P43403 2 606 619.0 ANP:60702 ATPlike Inactive DFGin 5.9276 12.4383 BLAplus -138.85, 178.0 51.18, 49.01 -84.24, -35.32 31.27, 105.54 -104.96, 20.24 out-out out 14.1129 Saltbr-out 13.9854 HRD-out -89.83, 129.13 -108.05, -14.5 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -15.2 APE8-dihe-out -67.79, 10.24 APE8-rot-na 350.79 APE67-dihe-in -82.13, -29.45 -101.33, 20.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 12.2697 D461N None None XRAY 3.0 0.213 0.287 A 614.0 543.0 17 31 14 17 [[338, 595]] 1.0 4k2r TYR_ZAP70_HUMAN TYR 8.6e-89 303.4 6.0 259.0 254.0 478 479 480 482 484 369 386 390 458 460 459 461.0 521 509 504 503 502 501 500 499 498 415 Tyrosine-protein kinase ZAP-70

Ligand: ANP

Total number of chains: 536
Active chains: 102
Total number of genes: 123
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 231 43.1% 8QCGA
DFGin BLBplus 158 29.5% 2SRCA
DFGin None 35 6.5% 6BXIA
DFGin ABAminus 34 6.3% 8R5EA
DFGin BLBtrans 34 6.3% 5X2AB
None None 12 2.2% 4IX5A
DFGin BLBminus 11 2.1% 4LGDA
DFGinter None 10 1.9% 7OPOG
DFGout None 6 1.1% 4I94A
DFGin BLAplus 5 0.9% 2OZOA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CKA1 CSK21_ARATH 6XX7A Q08467 77 406 409.0 ANP:60401 ATPlike Active DFGin 7.5219 16.0536 BLAminus -117.69, -174.69 54.04, 89.21 -108.75, 22.96 298.46, 82.8 -72.45, -17.87 in-in in 9.1971 Saltbr-in 3.1105 HRD-in -78.14, -48.74 65.41, 21.05 in-in-in SNCiii in-in ActLoopNT-in 2.8345 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.12, 170.49 APE9-dihe-na 62.76, -171.63 APE8-dihe-in -114.91, 151.01 APE8-rot-in 304.83 APE67-dihe-in -66.49, -17.41 -50.66, -50.22 APE12-dist-in 12.5854 APE11-dist-in 10.2831 APE10-dist-in 6.1876 APE9-dist-in 3.1341 None None None XRAY 2.4 0.198 0.246 A 342.0 330.0 0 27 27 0 [[110, 395]] 1.0 6xx7 Arabidopsis thaliana CMGC_CKA1_ARATH CMGC 2.6e-65 226.5 1.0 301.0 301.0 245 246 247 249 251 139 152 156 224 226 225 227.0 285 272 267 266 265 264 263 262 261 185 Casein kinase II subunit alpha-1
CMGC MPK4 MPK4_ARATH 7W5CA Q39024 18 372 376.0 ANP:401 ATPlike Inactive DFGin 6.7443 16.2248 BLAminus -128.66, -171.29 63.4, 64.26 -92.17, 14.29 279.32, 65.56 -68.22, -18.9 in-in in 9.0096 Saltbr-in 3.5788 HRD-in -71.53, -46.63 78.29, -8.64 in-in-out SNCiio in-out ActLoopNT-in 2.7029 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -115.93, 157.72 APE9-dihe-na -84.69, 1.94 APE8-dihe-in -132.03, 98.21 APE8-rot-out 46.99 APE67-dihe-in -68.07, -19.68 -80.43, -5.49 APE12-dist-out 6.2327 APE11-dist-in 10.9036 APE10-dist-out 8.9788 APE9-dist-out 11.6743 None None None XRAY 2.201 0.179 0.225 A 355.0 355.0 0 27 27 0 [[44, 329]] 1.0 7w5c Arabidopsis thaliana CMGC_MPK4_ARATH CMGC 1.3e-82 283.5 4.0 301.0 298.0 186 187 188 190 192 72 90 94 166 168 167 169.0 226 213 208 207 206 205 204 203 202 125 Mitogen-activated protein kinase 4
OTHER BSK8 BSK8_ARATH 4I94A Q9FHD7 40 328 487.0 ANP:60401 ATPlike Pseudo DFGout 11.0871 4.5792 None -62.85, 129.32 -64.9, -25.87 -61.66, -30.07 297.42, 140.17 -78.36, -1.16 out-out out 12.4918 Saltbr-out 11.1684 HRD-naV -138.88, 128.41 -94.79, 85.21 out-out-out SNCooo out-out ActLoopNT-out 8.1156 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -112.72, -1.39 APE9-dihe-na -99.73, 174.6 APE8-dihe-in -44.04, 124.87 APE8-rot-na 191.2 APE67-dihe-in -63.8, -11.97 -65.3, -25.56 APE12-dist-in 9.6511 APE11-dist-in 13.0353 APE10-dist-out 13.7384 APE9-dist-out 9.019 None None None XRAY 1.8 0.176 0.218 A 300.0 289.0 0 24 24 0 [[64, 311]] 1.0 4i94 Arabidopsis thaliana OTHER_BSK8_ARATH TKL 1.8e-32 119.0 14.0 264.0 251.0 198 199 200 202 204 87 103 107 178 180 179 181.0 234 222 217 216 215 214 213 212 211 133 Serine/threonine-protein kinase BSK8
OTHER BSK8 BSK8_ARATH 4I94B Q9FHD7 40 328 487.0 ANP:60401 ATPlike Pseudo DFGout 11.1674 4.5637 None -61.22, 131.83 -70.76, -19.93 -64.01, -28.32 298.7, 142.58 -77.56, -3.78 out-out out 12.6104 Saltbr-out 11.5622 HRD-naV -138.23, 125.02 -91.22, 87.17 out-out-out SNCooo out-out ActLoopNT-out 8.121 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -107.48, -5.73 APE9-dihe-na -87.26, 179.81 APE8-dihe-in -41.52, 121.65 APE8-rot-na 191.74 APE67-dihe-in -60.71, -19.43 -60.4, -25.91 APE12-dist-in 9.6381 APE11-dist-in 12.9661 APE10-dist-out 14.1361 APE9-dist-out 9.0483 None None None XRAY 1.8 0.176 0.218 B 300.0 289.0 0 24 24 0 [[64, 311]] 1.0 4i94 Arabidopsis thaliana OTHER_BSK8_ARATH TKL 1.8e-32 119.0 14.0 264.0 251.0 198 199 200 202 204 87 103 107 178 180 179 181.0 234 222 217 216 215 214 213 212 211 133 Serine/threonine-protein kinase BSK8
TKL BAK1 BAK1_ARATH 3UIMA Q94F62 272 573 615.0 ANP:1000 ATPlike Inactive DFGin 8.8521 13.2065 BLAminus -115.13, -165.77 41.37, 88.34 -98.5, 43.81 308.93, 97.2 -70.58, -44.49 in-out in 8.2806 Saltbr-out 5.242 HRD-in -79.94, -53.3 85.37, -6.05 out-in-none SNCoin in-none ActLoopNT-in 2.6407 ActLoopCT-none nonTYR APEdihe_aaini APEdist_iiii APE10-dihe-na -138.37, 177.14 APE9-dihe-na 106.88, -163.48 APE8-dihe-in -113.09, 162.35 APE8-rot-none 999.0 APE67-dihe-in -50.4, -34.12 -54.05, -40.71 APE12-dist-in 10.9122 APE11-dist-in 11.3003 APE10-dist-in 7.4138 APE9-dist-in 5.3194 None SEP290,TPO312,TPO446,TPO449,TPO450,TPO455 SEP290,TPO312,TPO446,TPO449,TPO450,TPO455 XRAY 2.2 0.237 0.277 A 326.0 297.0 5 29 29 0 [[288, 565]] 1.0 3uim Arabidopsis thaliana TKL_BAK1_ARATH TKL 5.8e-64 222.2 4.0 266.0 263.0 433 434 435 437 439 317 334 338 413 415 414 416.0 474 462 457 456 455 454 453 452 451 364 BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1
TKL BRI1 BRI1_ARATH 5LPVA O22476 867 1160 1196.0 ANP:1200 ATPlike Active DFGin 5.1436 14.9992 BLAminus -125.7, -177.27 57.44, 79.7 -100.2, 28.83 289.11, 69.34 -64.8, -27.23 in-in in 8.6162 Saltbr-in 2.6924 HRD-in -72.39, -48.96 69.78, 4.25 in-in-in SNCiii in-in ActLoopNT-in 2.9727 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.4, 152.93 APE9-dihe-na 138.14, -175.87 APE8-dihe-in -122.84, 131.25 APE8-rot-in 310.37 APE67-dihe-inflip 103.25, -12.92 -53.02, 126.73 APE12-dist-in 9.4988 APE11-dist-in 11.4352 APE10-dist-in 5.6666 APE9-dist-in 3.6712 T872A TPO1039,SEP1042,SEP1044 TPO1039,SEP1042,SEP1044 XRAY 2.7 0.193 0.233 A 296.0 285.0 9 30 30 0 [[882, 1157]] 1.0 5lpv Arabidopsis thaliana TKL_BRI1_ARATH TKL 2e-63 220.4 4.0 266.0 263.0 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009.0 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL BRI1 BRI1_ARATH 4OH4A O22476 863 1160 1196.0 ANP:61201 ATPlike Active DFGin 5.1089 14.6209 BLAminus -140.27, -170.9 60.42, 81.58 -96.75, 17.94 285.65, 72.49 -62.14, -24.45 in-in in 8.4295 Saltbr-in 2.9805 HRD-in -67.48, -45.07 71.79, 0.23 in-in-in SNCiii in-in ActLoopNT-in 2.8706 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.28, 137.25 APE9-dihe-na 143.97, 175.71 APE8-dihe-in -113.05, 131.41 APE8-rot-in 300.18 APE67-dihe-inflip 103.6, -22.59 -52.56, 134.8 APE12-dist-in 10.6878 APE11-dist-in 12.0604 APE10-dist-in 6.3282 APE9-dist-in 4.1239 None TPO1039,SEP1042,SEP1044,SEP1060 TPO1039,SEP1042,SEP1044,SEP1060 XRAY 2.25 0.203 0.236 A 333.0 292.0 6 30 30 0 [[882, 1157]] 1.0 4oh4 Arabidopsis thaliana TKL_BRI1_ARATH TKL 3e-63 219.8 4.0 266.0 263.0 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009.0 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL BRI1 BRI1_ARATH 4OH4B O22476 867 1160 1196.0 ANP:61201 ATPlike Active DFGin 5.0282 14.8658 BLAminus -128.92, -179.57 66.05, 81.1 -97.08, 13.19 285.07, 69.22 -52.61, -27.46 in-in in 8.6041 Saltbr-in 2.5854 HRD-in -68.96, -46.37 73.67, -10.15 in-in-in SNCiii in-in ActLoopNT-in 2.8697 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.43, 142.85 APE9-dihe-na 162.33, 170.81 APE8-dihe-in -132.62, 128.73 APE8-rot-in 297.7 APE67-dihe-inflip 104.71, -30.59 -48.41, 132.44 APE12-dist-in 9.4708 APE11-dist-in 10.3111 APE10-dist-in 5.1462 APE9-dist-in 4.0534 None TPO1039,SEP1042,SEP1044,SEP1060 TPO1039,SEP1042,SEP1044,SEP1060 XRAY 2.25 0.203 0.236 B 333.0 283.0 11 30 30 0 [[882, 1157]] 1.0 4oh4 Arabidopsis thaliana TKL_BRI1_ARATH TKL 3e-63 219.8 4.0 266.0 263.0 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009.0 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL BRI1 BRI1_ARATH 4Q5JA O22476 863 1160 1196.0 ANP:61201 ATPlike Active DFGin 5.0658 14.7399 BLAminus -137.9, 174.67 63.19, 85.3 -100.14, 20.42 284.87, 74.71 -62.5, -33.31 in-in in 8.3543 Saltbr-in 3.2574 HRD-in -68.22, -43.45 65.77, 3.93 in-in-in SNCiii in-in ActLoopNT-in 2.6621 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.48, 139.01 APE9-dihe-na 175.24, 173.84 APE8-dihe-in -115.42, 129.74 APE8-rot-in 289.59 APE67-dihe-inflip 96.87, -1.52 -53.59, 124.31 APE12-dist-in 10.51 APE11-dist-in 12.0649 APE10-dist-in 6.2358 APE9-dist-in 4.4668 None TPO1039,SEP1042,SEP1044,SEP1060 MSE925,MSE928,MSE959,MSE1010,MSE1030,MSE1034,MSE1037,TPO1039,SEP1042,SEP1044,SEP1060,MSE1117,MSE1148,MSE1152,MSE1154 XRAY 2.772 0.203 0.259 A 341.0 287.0 11 30 30 0 [[882, 1157]] 1.0 4q5j Arabidopsis thaliana TKL_BRI1_ARATH TKL 3.2e-63 219.7 4.0 266.0 263.0 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009.0 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL BRI1 BRI1_ARATH 4Q5JB O22476 867 1160 1196.0 ANP:61201 ATPlike Active DFGin 5.2589 14.7995 BLAminus -126.47, -178.56 58.45, 93.89 -112.89, 22.9 283.23, 71.66 -57.4, -19.56 in-in in 8.7318 Saltbr-in 3.1836 HRD-in -81.55, -35.96 67.72, -5.15 in-in-in SNCiii in-in ActLoopNT-in 2.7754 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -167.14, 134.16 APE9-dihe-na 157.62, 164.27 APE8-dihe-in -126.08, 123.8 APE8-rot-in 304.99 APE67-dihe-inflip 120.44, -28.11 -46.98, 122.06 APE12-dist-in 9.4035 APE11-dist-in 10.6356 APE10-dist-in 5.5117 APE9-dist-in 4.0814 None TPO1039,SEP1042,SEP1044,SEP1060 MSE925,MSE928,MSE959,MSE1010,MSE1030,MSE1034,MSE1037,TPO1039,SEP1042,SEP1044,SEP1060,MSE1117,MSE1148,MSE1152,MSE1154 XRAY 2.772 0.203 0.259 B 341.0 283.0 11 30 30 0 [[882, 1157]] 1.0 4q5j Arabidopsis thaliana TKL_BRI1_ARATH TKL 3.2e-63 219.7 4.0 266.0 263.0 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009.0 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL CARK1 CARK1_ARATH 5XD6A Q9LUT0 50 350 364.0 ANP:61000 ATPlike Inactive DFGin 5.2866 13.9895 None -82.23, -179.6 -66.2, 154.72 -113.7, 177.91 45.1, 88.76 -91.38, 112.57 out-na out 13.41 Saltbr-na 13.4762 HRD-in -67.99, -48.34 77.3, -6.84 na-out-none SNCaon out-none ActLoopNT-out 8.2956 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 12.83 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.898 0.218 0.251 A 305.0 278.0 23 30 13 17 [[67, 347]] 1.0 5xd6 Arabidopsis thaliana TKL_CARK1_ARATH TKL 9e-61 211.7 4.0 266.0 263.0 216 217 218 220 222 97 112 116 196 198 197 199.0 258 246 241 240 239 238 237 236 235 142 Protein CYTOSOLIC ABA RECEPTOR KINASE 1
TKL CARK1 CARK1_ARATH 5XD6B Q9LUT0 50 350 364.0 ANP:61000 ATPlike Inactive DFGin 5.6295 13.9302 None -77.44, -177.16 -70.67, 157.78 -117.63, 177.11 50.67, 89.87 -85.72, 109.22 out-na out 13.6757 Saltbr-na 14.0861 HRD-in -75.16, -46.81 74.28, -9.17 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -2.12 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.898 0.218 0.251 B 305.0 282.0 19 30 11 19 [[67, 347]] 1.0 5xd6 Arabidopsis thaliana TKL_CARK1_ARATH TKL 9e-61 211.7 4.0 266.0 263.0 216 217 218 220 222 97 112 116 196 198 197 199.0 258 246 241 240 239 238 237 236 235 142 Protein CYTOSOLIC ABA RECEPTOR KINASE 1
TKL SOBIR1 SBIR1_ARATH 7CTVA Q9SKB2 326 639 641.0 ANP:60702 ATPlike Inactive DFGin 6.6608 13.8853 BLBminus -141.13, -179.6 54.72, 58.77 -66.01, 150.7 286.65, 72.17 -81.72, 124.12 out-none out 15.112 Saltbr-none 999.0 HRD-out -87.3, 102.63 -86.62, 6.82 none-out-out SNCnoo out-out ActLoopNT-out 9.5209 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -76.63, -5.1 APE9-dihe-na 65.07, 35.87 APE8-dihe-out -126.08, 24.51 APE8-rot-out 59.01 APE67-dihe-in -54.76, -18.48 -67.58, -32.17 APE12-dist-out 20.7618 APE11-dist-out 20.4915 APE10-dist-out 17.1794 APE9-dist-out 13.9703 D489A None None XRAY 2.886 0.218 0.239 A 336.0 297.0 17 30 30 0 [[343, 638]] 1.0 7ctv Arabidopsis thaliana TKL_SOBIR1_ARATH TKL 8.4e-57 198.7 4.0 266.0 263.0 506 507 508 510 512 377 407 411 486 488 487 489.0 548 536 531 530 529 528 527 526 525 437 Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1
TKL SOBIR1 SBIR1_ARATH 7CTVB Q9SKB2 326 640 641.0 ANP:60702 ATPlike Inactive DFGin 6.421 13.8703 BLBminus -144.86, -178.02 49.22, 64.23 -62.65, 147.84 294.25, 70.22 -69.54, 92.84 out-none out 15.2531 Saltbr-none 999.0 HRD-out -90.69, 89.36 -71.79, -21.49 none-out-out SNCnoo out-out ActLoopNT-out 9.1207 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -77.41, -5.23 APE9-dihe-na 69.76, 25.67 APE8-dihe-out -112.95, 17.98 APE8-rot-out 72.42 APE67-dihe-in -62.91, -23.09 -65.66, -31.24 APE12-dist-out 20.1323 APE11-dist-out 19.7591 APE10-dist-out 16.4315 APE9-dist-out 13.6326 D489A None None XRAY 2.886 0.218 0.239 B 336.0 292.0 23 30 30 0 [[343, 638]] 1.0 7ctv Arabidopsis thaliana TKL_SOBIR1_ARATH TKL 8.4e-57 198.7 4.0 266.0 263.0 506 507 508 510 512 377 407 411 486 488 487 489.0 548 536 531 530 529 528 527 526 525 437 Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1
TKL SOBIR1 SBIR1_ARATH 7CTXA Q9SKB2 326 639 641.0 ANP:60701 ATPlike Inactive DFGin 5.9245 13.9577 BLBplus -138.51, 171.55 56.64, 47.79 -120.23, 164.88 60.27, 92.94 88.0, -43.52 out-out out 14.426 Saltbr-out 14.6199 HRD-in -69.62, -53.51 75.07, -7.08 out-out-out SNCooo out-out ActLoopNT-out 8.647 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -78.29, -6.92 APE9-dihe-na 74.92, 27.29 APE8-dihe-out -123.12, 22.17 APE8-rot-out 54.06 APE67-dihe-in -63.92, -13.63 -66.83, -19.82 APE12-dist-out 21.8717 APE11-dist-out 21.4602 APE10-dist-out 18.2821 APE9-dist-out 14.1209 None None None XRAY 2.907 0.226 0.243 A 323.0 293.0 8 30 30 0 [[343, 638]] 1.0 7ctx Arabidopsis thaliana TKL_SOBIR1_ARATH TKL 1.3e-59 207.9 4.0 266.0 263.0 506 507 508 510 512 377 407 411 486 488 487 489.0 548 536 531 530 529 528 527 526 525 437 Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1
TKL SOBIR1 SBIR1_ARATH 7CTXB Q9SKB2 326 640 641.0 ANP:60701 ATPlike Inactive DFGin 5.8751 13.9927 BLBplus -137.44, 176.16 58.26, 44.88 -125.18, 162.12 65.68, 87.66 87.14, -0.96 out-out out 14.0627 Saltbr-out 13.6314 HRD-in -66.8, -55.86 75.55, -4.98 out-out-out SNCooo out-out ActLoopNT-out 8.8498 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -76.44, -5.32 APE9-dihe-na 71.29, 28.46 APE8-dihe-out -125.93, 28.87 APE8-rot-out 53.38 APE67-dihe-in -62.75, -12.89 -73.08, -23.74 APE12-dist-out 21.6184 APE11-dist-out 21.3279 APE10-dist-out 18.1913 APE9-dist-out 14.3165 None None None XRAY 2.907 0.226 0.243 B 323.0 297.0 5 30 30 0 [[343, 638]] 1.0 7ctx Arabidopsis thaliana TKL_SOBIR1_ARATH TKL 1.3e-59 207.9 4.0 266.0 263.0 506 507 508 510 512 377 407 411 486 488 487 489.0 548 536 531 530 529 528 527 526 525 437 Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1
AGC PRKACA KAPCA_BOVIN 9DW5G P00517 13 351 351.0 ANP:403 ATPlike None DFGin 7.3339 15.8767 BLAminus -126.22, -169.89 60.75, 61.77 -87.02, 21.16 273.51, 93.96 -63.0, -33.74 out-none out 10.2523 Saltbr-none 999.0 HRD-in -80.85, -56.62 73.43, -6.68 none-in-in SNCnii in-in ActLoopNT-in 2.7819 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -167.11, -173.97 APE9-dihe-na 106.0, -157.25 APE8-dihe-in -108.29, 136.12 APE8-rot-in 326.0 APE67-dihe-in -63.46, -43.06 -59.57, -33.75 APE12-dist-in 9.1133 APE11-dist-in 11.9553 APE10-dist-in 6.8101 APE9-dist-in 4.5632 None TPO198 TPO198 EM 3.8 999.0 999.0 G 351.0 330.0 0 25 25 0 [[44, 298]] 1.0 9dw5 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 9DW8G P00517 15 329 351.0 ANP:403 ATPlike None DFGin 6.0696 14.2353 BLAminus -131.43, -174.72 59.27, 66.66 -86.28, 33.46 293.19, 93.28 -61.23, -49.05 in-none in 9.9111 Saltbr-none 999.0 HRD-in -98.32, -49.71 57.42, 11.15 none-in-in SNCnii in-in ActLoopNT-in 2.9612 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -168.06, 160.73 APE9-dihe-na 123.3, -175.7 APE8-dihe-in -89.52, 132.72 APE8-rot-in 298.44 APE67-dihe-in -69.93, -27.98 -56.75, -38.6 APE12-dist-in 8.7001 APE11-dist-in 11.5933 APE10-dist-in 6.4109 APE9-dist-in 4.8026 None TPO198 TPO198 EM 3.5 999.0 999.0 G 351.0 309.0 0 25 25 0 [[44, 298]] 1.0 9dw8 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 9DW7G P00517 13 351 351.0 ANP:403 ATPlike Inactive None 999.0 999.0 None -155.4, -162.2 59.11, 63.62 -70.57, 12.19 999.0, 999.0 -65.51, -34.83 out-none out 10.9713 Saltbr-none 999.0 HRD-in -65.14, -55.26 50.7, 27.28 none-in-out SNCnio in-out ActLoopNT-in 2.5754 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iiio APE10-dihe-na -166.96, 170.69 APE9-dihe-na 108.98, -156.8 APE8-dihe-in -102.79, 139.06 APE8-rot-none 999.0 APE67-dihe-in -58.63, -28.81 -67.98, -6.96 APE12-dist-in 9.2283 APE11-dist-in 10.2672 APE10-dist-in 6.4383 APE9-dist-out 6.202 None None None EM 6.0 999.0 999.0 G 351.0 339.0 0 25 25 0 [[44, 298]] 1.0 9dw7 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
TYR LET23 LET23_CAEEL 5WNOA P24348 876 1190 1323.0 ANP:1201 ATPlike Inactive DFGin 6.2472 12.8766 BLBplus -129.17, 177.47 55.99, 43.49 -103.44, 159.44 53.09, 86.5 67.88, 29.06 out-out out 14.4646 Saltbr-out 14.5171 HRD-in -74.41, -38.75 70.96, -11.0 out-out-out SNCooo out-out ActLoopNT-out 7.6383 ActLoopCT-out TYR APEdihe_nooai APEdist_aaao APE10-dihe-none 999.0, -139.66 APE9-dihe-out -62.23, -13.83 APE8-dihe-out -67.85, 10.53 APE8-rot-na 999.0 APE67-dihe-in -61.61, -23.35 -63.66, -29.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.694 APE9-dist-out 10.8591 None None None XRAY 2.386 0.217 0.247 A 330.0 302.0 13 30 18 12 [[885, 1143]] 1.0 5wno Caenorhabditis elegans TYR_LET23_CAEEL TYR 1.6e-78 269.6 2.0 260.0 259.0 1027 1028 1029 1031 1033 919 934 938 1007 1009 1008 1010.0 1069 1057 1052 1051 1050 1049 1048 1047 1046 964 Receptor tyrosine-protein kinase let-23
CMGC CK2 Q5KF69_CRYD1 6ISEA Q5KF69 5 331 336.0 ANP:403 ATPlike Active DFGin 7.3392 16.2078 BLAminus -129.3, -170.99 44.36, 71.77 -91.05, 22.67 299.01, 82.29 -66.02, -23.99 in-in in 9.4822 Saltbr-in 3.3362 HRD-in -65.48, -54.09 76.82, 9.27 in-in-in SNCiii in-in ActLoopNT-in 2.9136 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.0, -19.23 APE9-dihe-na -99.69, -172.72 APE8-dihe-in -80.09, 147.5 APE8-rot-in 301.93 APE67-dihe-in -61.24, -16.59 -47.75, -58.81 APE12-dist-in 12.6869 APE11-dist-in 10.6311 APE10-dist-in 6.1443 APE9-dist-in 3.6087 None None None XRAY 2.8 0.198 0.23 A 338.0 327.0 0 27 27 0 [[38, 323]] 1.0 6ise Cryptococcus deneoformans CMGC_CK2_CRYD1 CMGC 6e-64 222.0 1.0 301.0 301.0 173 174 175 177 179 67 80 84 152 154 153 155.0 213 200 195 194 193 192 191 190 189 113 Casein kinase II subunit alpha
CMGC CK2 Q5KF69_CRYD1 6ISEB Q5KF69 5 331 336.0 ANP:403 ATPlike Active DFGin 7.3075 16.2384 BLAminus -133.11, -171.48 44.36, 73.35 -91.98, 23.51 299.28, 79.86 -68.68, -21.78 in-in in 9.5908 Saltbr-in 3.4961 HRD-in -67.7, -51.8 75.87, 7.92 in-in-in SNCiii in-in ActLoopNT-in 2.9761 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.38, 168.0 APE9-dihe-na 74.76, -173.48 APE8-dihe-in -110.86, 148.66 APE8-rot-in 271.82 APE67-dihe-in -65.62, -23.31 -54.68, -45.78 APE12-dist-in 12.5765 APE11-dist-in 10.3109 APE10-dist-in 6.2661 APE9-dist-in 3.3672 None None None XRAY 2.8 0.198 0.23 B 338.0 327.0 0 27 27 0 [[38, 323]] 1.0 6ise Cryptococcus deneoformans CMGC_CK2_CRYD1 CMGC 6e-64 222.0 1.0 301.0 301.0 173 174 175 177 179 67 80 84 152 154 153 155.0 213 200 195 194 193 192 191 190 189 113 Casein kinase II subunit alpha
CMGC CKA1 J9VNH4_CRYN9 6KO6B J9VNH4 5 334 338.0 ANP:401 ATPlike Active DFGin 7.2981 16.2364 BLAminus -115.02, -165.9 52.87, 72.55 -94.97, 21.12 299.2, 77.23 -71.99, -18.35 in-in in 9.3237 Saltbr-in 3.1512 HRD-in -64.53, -49.64 63.27, 19.41 in-in-in SNCiii in-in ActLoopNT-in 3.0553 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.45, 156.98 APE9-dihe-na 76.83, -179.82 APE8-dihe-in -92.38, 159.35 APE8-rot-in 277.62 APE67-dihe-in -71.62, -13.46 -53.06, -52.26 APE12-dist-in 12.7924 APE11-dist-in 10.4743 APE10-dist-in 6.1773 APE9-dist-in 3.2488 None None None XRAY 2.4 0.238 0.268 B 338.0 330.0 0 27 27 0 [[38, 323]] 1.0 6ko6 Cryptococcus neoformans CMGC_CKA1_CRYN9 CMGC 6e-64 222.0 1.0 301.0 301.0 173 174 175 177 179 67 80 84 152 154 153 155.0 213 200 195 194 193 192 191 190 189 113 Casein kinase II subunit alpha
CAMK CDPK1 A3FQ16_CRYPI 3IGOA A3FQ16 70 537 538.0 ANP:60610 ATPlike Inactive DFGin 6.7066 13.4651 BLBplus -121.25, 174.97 67.47, 60.04 -154.02, 168.86 59.26, 84.09 92.58, -14.73 out-out out 14.2087 Saltbr-out 13.0649 HRD-in -63.43, -55.21 83.61, -21.71 out-out-out SNCooo out-out ActLoopNT-out 9.0298 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 153.6 APE8-rot-out 169.15 APE67-dihe-in -51.84, -35.84 -53.96, -31.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.25 0.205 0.258 A 486.0 445.0 8 27 20 7 [[76, 332]] 1.0 3igo Cryptosporidium parvum CAMK_CDPK1_CRYPI CAMK 3.4e-90 308.1 1.0 256.0 256.0 218 219 220 222 224 105 123 127 195 197 196 198.0 256 245 240 239 238 237 236 235 234 153 non-specific serine/threonine protein kinase
CAMK CDPK3 Q5CS01_CRYPI 3LIJA Q5CS01 42 516 523.0 ANP:60522 ATPlike Inactive DFGin 7.0342 14.6546 BLAminus -127.46, 177.5 59.13, 85.54 -100.29, 19.94 282.89, 79.61 -59.37, -32.9 out-out out 10.177 Saltbr-out 5.2556 HRD-in -74.61, -49.83 71.32, -4.41 out-in-in SNCoii in-in ActLoopNT-in 2.9357 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.48, 149.72 APE9-dihe-na 141.55, -153.66 APE8-dihe-in -128.1, 132.61 APE8-rot-in 307.4 APE67-dihe-in -65.62, -35.53 -34.47, -55.78 APE12-dist-in 8.691 APE11-dist-in 11.6597 APE10-dist-in 5.7815 APE9-dist-in 3.5691 None None None XRAY 1.9 0.203 0.229 A 494.0 461.0 8 27 27 0 [[62, 318]] 1.0 3lij Cryptosporidium parvum CAMK_CDPK3_CRYPI CAMK 2.7e-91 311.6 1.0 256.0 256.0 204 205 206 208 210 91 109 113 181 183 182 184.0 242 231 226 225 224 223 222 221 220 139 Calcium-dependent protein kinase 1
CAMK CDPK4-2 Q5CZ29_CRYPI 3HKOA Q5CZ29 126 452 824.0 ANP:60329 ATPlike Inactive DFGin 5.9519 15.5829 ABAminus -120.43, 2.55 -135.28, 127.73 -128.94, 23.59 286.29, 84.57 -62.1, -26.95 out-out out 10.1114 Saltbr-out 4.4341 HRD-in -76.09, -50.74 72.63, 1.72 out-in-out SNCoio in-out ActLoopNT-in 2.7733 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, -104.24 APE9-dihe-na 126.39, -179.13 APE8-dihe-in -75.92, 124.68 APE8-rot-in 280.37 APE67-dihe-in -53.45, -34.89 -49.78, -39.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.4056 APE9-dist-in 3.7216 None None None XRAY 1.8 0.204 0.246 A 345.0 314.0 13 32 24 8 [[135, 237], [261, 441]] 2.0 3hko Cryptosporidium parvum CAMK_CDPK4-2_CRYPI CAMK 1.5e-19 241.1 1.0 89.0 250.0 319 320 321 323 325 164 185 189 297 299 298 300.0 365 351 346 345 344 343 342 341 340 215 non-specific serine/threonine protein kinase
CMGC BSK JNK_DROME 5AWMA P92208 7 362 372.0 ANP:401 ATPlike Inactive DFGin 3.9678 14.3041 ABAminus -88.58, -21.58 -138.57, 174.5 -114.07, -2.87 300.82, 95.37 86.6, -153.47 out-out out 10.4287 Saltbr-out 5.2581 HRD-in -75.17, -58.38 75.26, -11.27 out-out-out SNCooo out-out ActLoopNT-out 6.3567 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -11.69 APE9-dihe-na -122.62, 142.03 APE8-dihe-in -71.85, 116.06 APE8-rot-in 300.48 APE67-dihe-in -65.6, -18.22 -112.19, 0.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.382 APE9-dist-out 11.1663 None None None XRAY 1.79 0.179 0.22 A 394.0 345.0 9 27 24 3 [[24, 320]] 1.0 5awm Drosophila melanogaster CMGC_BSK_DROME CMGC 8.1e-82 280.8 1.0 301.0 301.0 166 167 168 170 172 53 71 75 146 148 147 149.0 205 193 188 187 186 185 184 183 182 107 Stress-activated protein kinase JNK
STE DSOR1 DSOR1_DROME 8BW9C Q24324 81 384 396.0 ANP:60401,QOM:60402 ATPlike,Type3 Inactive DFGin 5.4773 14.249 BLBplus -159.47, 168.77 62.79, 56.43 -107.18, 135.07 48.27, 89.36 -64.21, 107.83 out-out out 15.5585 Saltbr-out 19.8405 HRD-in -58.37, -64.17 71.81, -9.38 out-out-out SNCooo out-out ActLoopNT-out 8.8494 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -115.48, -57.78 APE9-dihe-na 75.76, 170.55 APE8-dihe-out -89.06, -0.85 APE8-rot-out 170.28 APE67-dihe-out -125.12, 142.75 -125.31, 123.31 APE12-dist-out 17.3843 APE11-dist-out 19.5261 APE10-dist-out 21.9991 APE9-dist-out 14.6441 None None None EM 3.32 999.0 999.0 C 396.0 280.0 24 26 26 0 [[87, 364]] 1.0 8bw9 Drosophila melanogaster STE_DSOR1_DROME STE 2.5e-90 308.3 2.0 256.0 255.0 226 227 228 230 232 116 133 137 206 208 207 209.0 264 252 247 246 245 244 243 242 241 163 Dual specificity mitogen-activated protein kinase kinase dSOR1
TYR PTK2 FAK1_CHICK 2J0LA Q00944 411 686 1053.0 ANP:1689 ATPlike Inactive DFGin 7.0415 15.5948 BLAminus -124.12, -151.88 51.86, 82.15 -108.03, 32.91 286.36, 85.03 -71.96, -36.63 in-in in 7.8243 Saltbr-in 2.777 HRD-in -78.92, -53.9 78.76, -8.92 in-in-out SNCiio in-out ActLoopNT-in 2.9564 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -71.98, 100.38 APE9-dihe-in -65.3, 130.79 APE8-dihe-in -75.31, 71.06 APE8-rot-na 28.66 APE67-dihe-in -69.29, -16.82 -49.9, -41.21 APE12-dist-na 11.3874 APE11-dist-na 10.2564 APE10-dist-na 13.5329 APE9-dist-out 8.2789 None PTR576,PTR577 PTR576,PTR577 XRAY 2.3 0.217 0.263 A 276.0 276.0 0 29 29 0 [[422, 678]] 1.0 2j0l Gallus gallus TYR_PTK2_CHICK TYR 2.6e-93 318.0 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 6TY4A Q00944 34 686 1053.0 ANP:702 ATPlike Active DFGin 7.5465 15.9507 BLAminus -124.05, -151.88 51.86, 82.13 -107.99, 32.9 286.39, 85.0 -72.01, -36.58 in-in in 8.4374 Saltbr-in 3.5618 HRD-in -70.16, -30.0 74.19, -18.38 in-in-in SNCiii in-in ActLoopNT-in 2.8146 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.31, 66.54 APE9-dihe-in -63.31, 139.75 APE8-dihe-in -64.41, 127.23 APE8-rot-na 22.65 APE67-dihe-in -56.19, -42.03 -70.19, -41.73 APE12-dist-na 11.4889 APE11-dist-na 10.1836 APE10-dist-na 13.6359 APE9-dist-in 7.205 None None None EM 5.96 999.0 999.0 A 658.0 621.0 0 29 29 0 [[422, 678]] 1.0 6ty4 Gallus gallus TYR_PTK2_CHICK TYR 1.5e-91 312.7 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 6TY4B Q00944 34 686 1053.0 ANP:702 ATPlike Active DFGin 7.5463 15.9503 BLAminus -124.03, -151.9 51.82, 82.14 -107.99, 32.89 286.33, 85.06 -71.97, -36.56 in-in in 8.4362 Saltbr-in 3.562 HRD-in -70.15, -30.0 74.26, -18.38 in-in-in SNCiii in-in ActLoopNT-in 2.8146 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.3, 66.56 APE9-dihe-in -63.34, 139.79 APE8-dihe-in -64.42, 127.23 APE8-rot-na 22.65 APE67-dihe-in -56.21, -42.01 -70.19, -41.71 APE12-dist-na 11.4889 APE11-dist-na 10.1834 APE10-dist-na 13.6363 APE9-dist-in 7.2047 None None None EM 5.96 999.0 999.0 B 658.0 621.0 0 29 29 0 [[422, 678]] 1.0 6ty4 Gallus gallus TYR_PTK2_CHICK TYR 1.5e-91 312.7 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
AGC AKT1 AKT1_HUMAN 4EKKA P31749 144 477 480.0 ANP:60501 ATPlike Active DFGin 6.0476 13.1126 BLAminus -112.5, -177.27 66.46, 90.66 -111.95, 23.34 296.26, 86.16 -69.26, -23.9 in-in in 8.6509 Saltbr-in 2.9785 HRD-in -63.51, -40.13 66.5, -18.58 in-in-in SNCiii in-in ActLoopNT-in 3.0497 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.71, 172.01 APE9-dihe-na 121.09, -152.4 APE8-dihe-in -119.32, 125.09 APE8-rot-in 285.38 APE67-dihe-in -63.61, -25.53 -44.69, -42.52 APE12-dist-in 8.8136 APE11-dist-in 11.7177 APE10-dist-in 6.0702 APE9-dist-in 4.0693 S473D TPO308 TPO308 XRAY 2.8 0.22 0.28 A 341.0 319.0 0 28 28 0 [[150, 408]] 1.0 4ekk Homo sapiens AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 4EKKB P31749 144 477 480.0 ANP:60501 ATPlike Active DFGin 6.0752 13.0461 BLAminus -112.98, 175.61 60.18, 117.01 -127.72, 18.67 304.81, 92.19 -54.85, -36.32 in-in in 8.7662 Saltbr-in 2.6652 HRD-in -65.56, -47.0 73.75, -27.2 in-in-in SNCiii in-in ActLoopNT-in 2.8192 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.2, 164.76 APE9-dihe-na 136.6, -155.35 APE8-dihe-in -114.57, 129.15 APE8-rot-in 273.31 APE67-dihe-in -63.86, -22.96 -45.74, -46.48 APE12-dist-in 8.7699 APE11-dist-in 11.6858 APE10-dist-in 6.1252 APE9-dist-in 4.2849 S473D TPO308 TPO308 XRAY 2.8 0.22 0.28 B 341.0 319.0 0 28 28 0 [[150, 408]] 1.0 4ekk Homo sapiens AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 1O6KA P31751 146 479 481.0 ANP:1480 ATPlike Active DFGin 6.146 12.7344 BLAminus -120.8, -176.05 56.87, 82.9 -98.82, 24.49 299.36, 92.56 -61.37, -25.29 in-in in 8.7488 Saltbr-in 2.7955 HRD-in -73.34, -45.79 65.54, -9.2 in-in-in SNCiii in-in ActLoopNT-in 3.0271 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.85, 170.7 APE9-dihe-na 130.02, -155.15 APE8-dihe-in -119.36, 127.57 APE8-rot-in 291.96 APE67-dihe-in -68.55, -16.48 -36.55, -56.12 APE12-dist-in 8.1933 APE11-dist-in 11.7594 APE10-dist-in 6.1185 APE9-dist-in 3.9212 S474D TPO309 TPO309 XRAY 1.7 0.205 0.234 A 336.0 318.0 0 28 28 0 [[152, 409]] 1.0 1o6k Homo sapiens AGC_AKT2_HUMAN AGC 1.7e-99 338.1 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 1O6LA P31751 146 477 481.0 ANP:61480 ATPlike Active DFGin 6.2578 12.9248 BLAminus -121.53, -178.18 58.41, 83.34 -98.83, 24.71 297.57, 89.85 -63.5, -19.94 in-in in 8.7937 Saltbr-in 2.7601 HRD-in -74.06, -43.29 62.88, -5.6 in-in-in SNCiii in-in ActLoopNT-in 3.0061 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.79, 169.91 APE9-dihe-na 133.49, -153.33 APE8-dihe-in -120.8, 127.55 APE8-rot-in 289.07 APE67-dihe-in -68.04, -17.15 -37.13, -54.04 APE12-dist-in 8.1734 APE11-dist-in 11.7399 APE10-dist-in 6.1223 APE9-dist-in 3.747 None TPO309 TPO309 XRAY 1.6 0.198 0.227 A 337.0 312.0 0 28 28 0 [[152, 409]] 1.0 1o6l Homo sapiens AGC_AKT2_HUMAN AGC 1.8e-99 338.1 1.0 260.0 260.0 292 293 294 296 298 181 200 204 272 274 273 275.0 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC GRK5 GRK5_HUMAN 4TNDA P34947 15 543 590.0 ANP:601 ATPlike Active DFGin 5.282 13.1718 BLAminus -119.9, 173.82 59.88, 73.64 -89.53, 7.87 278.21, 112.8 -54.71, -33.69 in-in in 9.1929 Saltbr-in 3.0526 HRD-in -67.8, -56.87 74.64, -6.61 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.25, 150.21 APE9-dihe-na 143.02, -165.26 APE8-dihe-in -107.11, 142.28 APE8-rot-in 314.69 APE67-dihe-inflip 92.64, -22.22 -59.58, 132.94 APE12-dist-in 10.3015 APE11-dist-in 12.0563 APE10-dist-in 6.2302 APE9-dist-in 4.2553 None None None XRAY 1.802 0.174 0.205 A 590.0 529.0 0 27 27 0 [[186, 448]] 1.0 4tnd Homo sapiens AGC_GRK5_HUMAN AGC 1.1e-83 286.4 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK6 GRK6_HUMAN 2ACXA P43250 14 532 576.0 ANP:577 ATPlike Active DFGin 6.2066 13.2835 BLAminus -133.82, 164.79 58.79, 76.03 -96.19, 24.41 281.42, 82.4 -59.68, -24.05 in-in in 9.3415 Saltbr-in 3.2194 HRD-in -78.26, -56.85 77.2, -1.95 in-in-in SNCiii in-in ActLoopNT-in 2.9714 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.49, 157.4 APE9-dihe-na 123.02, -168.26 APE8-dihe-in -95.03, 140.31 APE8-rot-in 303.17 APE67-dihe-in -86.56, -0.13 -45.11, -52.69 APE12-dist-in 10.4784 APE11-dist-in 11.834 APE10-dist-in 6.0832 APE9-dist-in 3.9058 C561S,C562S,C565S None None XRAY 2.6 0.204 0.243 A 576.0 495.0 0 27 27 0 [[186, 448]] 1.0 2acx Homo sapiens AGC_GRK6_HUMAN AGC 2e-85 292.1 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 6
AGC GRK6 GRK6_HUMAN 2ACXB P43250 14 535 576.0 ANP:577 ATPlike Active DFGin 6.0903 13.1455 BLAminus -128.37, 163.87 55.35, 87.14 -100.56, 21.26 285.61, 77.77 -55.4, -30.56 in-in in 9.2313 Saltbr-in 2.4394 HRD-in -77.3, -59.12 75.78, 1.97 in-in-in SNCiii in-in ActLoopNT-in 2.9766 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.83, 161.38 APE9-dihe-na 125.99, -167.44 APE8-dihe-in -95.89, 144.8 APE8-rot-in 307.19 APE67-dihe-in -70.72, -14.39 -48.06, -55.51 APE12-dist-in 10.4768 APE11-dist-in 11.8719 APE10-dist-in 6.1674 APE9-dist-in 3.7096 C561S,C562S,C565S None None XRAY 2.6 0.204 0.243 B 576.0 492.0 5 27 27 0 [[186, 448]] 1.0 2acx Homo sapiens AGC_GRK6_HUMAN AGC 2e-85 292.1 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 6
AGC PRKCB KPCB_HUMAN 8SE1A P05771 19 668 671.0 ANP:60706 ATPlike Active DFGin 6.0073 12.8387 BLAminus -130.5, -169.38 54.07, 70.37 -91.85, 35.76 301.77, 99.49 -89.35, 3.84 in-in in 8.3368 Saltbr-in 2.5243 HRD-in -91.65, -37.95 43.68, 28.8 in-in-in SNCiii in-in ActLoopNT-in 3.1603 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.86, 170.42 APE9-dihe-na 126.28, -151.58 APE8-dihe-in -120.81, 128.88 APE8-rot-in 299.44 APE67-dihe-in -79.06, -41.06 -50.17, -27.42 APE12-dist-in 8.8802 APE11-dist-in 12.1775 APE10-dist-in 6.66 APE9-dist-in 3.6111 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 3.32 0.202 0.256 A 674.0 607.0 0 28 28 0 [[342, 600]] 1.0 8se1 Homo sapiens AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1.0 260.0 260.0 483 484 485 487 489 371 390 394 463 465 464 466.0 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC PRKCB KPCB_HUMAN 8SE1B P05771 19 668 671.0 ANP:60706 ATPlike Active DFGin 6.0933 12.7785 BLAminus -130.75, -169.0 53.85, 70.09 -92.15, 34.96 301.62, 99.67 -90.48, 2.45 in-in in 8.3118 Saltbr-in 2.2159 HRD-in -89.42, -35.84 47.27, 23.7 in-in-in SNCiii in-in ActLoopNT-in 3.2838 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.83, 169.92 APE9-dihe-na 126.33, -152.59 APE8-dihe-in -121.43, 128.62 APE8-rot-in 299.3 APE67-dihe-in -78.67, -41.09 -50.34, -26.64 APE12-dist-in 8.7218 APE11-dist-in 12.1824 APE10-dist-in 6.7091 APE9-dist-in 3.7667 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 3.32 0.202 0.256 B 674.0 631.0 0 28 28 0 [[342, 600]] 1.0 8se1 Homo sapiens AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1.0 260.0 260.0 483 484 485 487 489 371 390 394 463 465 464 466.0 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC PRKCB KPCB_HUMAN 8SE2B P05771 30 671 671.0 ANP:701 ATPlike Active DFGin 5.7063 12.7369 BLAminus -122.79, -175.57 50.54, 85.22 -103.07, 33.77 300.25, 95.58 -78.87, -5.25 in-in in 8.251 Saltbr-in 2.6747 HRD-in -90.05, -48.77 75.62, -5.68 in-in-in SNCiii in-in ActLoopNT-in 3.1255 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.22, 161.28 APE9-dihe-na 125.49, -179.08 APE8-dihe-in -100.09, 129.99 APE8-rot-in 297.02 APE67-dihe-in -66.56, -21.71 -49.98, -38.79 APE12-dist-in 8.6339 APE11-dist-in 11.7118 APE10-dist-in 6.2234 APE9-dist-in 3.6063 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 2.95 0.196 0.252 B 672.0 589.0 0 28 28 0 [[342, 600]] 1.0 8se2 Homo sapiens AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1.0 260.0 260.0 483 484 485 487 489 371 390 394 463 465 464 466.0 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC PRKCI KPCI_HUMAN 8R3YI P41743 248 585 596.0 ANP:60601 ATPlike Inactive DFGin 6.3715 12.4884 ABAminus -142.84, 3.21 -114.63, 115.49 -97.57, 12.92 307.39, 117.32 -57.63, -54.79 in-out in 9.8164 Saltbr-out 4.2411 HRD-in -70.43, -26.71 66.29, -17.13 out-in-in SNCoii in-in ActLoopNT-in 2.9084 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.32, 161.33 APE9-dihe-na 102.59, 162.36 APE8-dihe-in -70.48, 133.74 APE8-rot-in 297.7 APE67-dihe-in -64.44, -18.95 -54.13, -38.16 APE12-dist-in 8.8632 APE11-dist-in 11.2821 APE10-dist-in 5.8559 APE9-dist-in 3.4976 None TPO412,TPO564 TPO412,TPO564 EM 3.68 999.0 999.0 I 338.0 338.0 0 28 28 0 [[254, 522]] 1.0 8r3y Homo sapiens AGC_PRKCI_HUMAN AGC 1e-95 325.7 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 5LI1A P41743 248 589 596.0 ANP:60601 ATPlike Active DFGin 5.0788 11.9615 BLAminus -129.24, 176.98 73.22, 90.17 -103.83, 11.43 308.18, 130.49 -69.42, -18.98 in-in in 8.413 Saltbr-in 2.8162 HRD-in -77.28, -52.44 73.77, 3.75 in-in-in SNCiii in-in ActLoopNT-in 2.9747 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.65, 168.01 APE9-dihe-na 127.57, -168.6 APE8-dihe-in -111.48, 126.0 APE8-rot-in 296.01 APE67-dihe-in -54.62, -31.15 -46.95, -45.66 APE12-dist-in 8.7516 APE11-dist-in 11.8219 APE10-dist-in 6.3097 APE9-dist-in 3.5172 None TPO412,SEP484,TPO564 TPO412,SEP484,TPO564 XRAY 2.0 0.154 0.217 A 354.0 332.0 10 28 28 0 [[254, 522]] 1.0 5li1 Homo sapiens AGC_PRKCI_HUMAN AGC 1.2e-95 325.5 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKG1 KGP1_HUMAN 6BG2A Q13976 336 671 671.0 ANP:700 ATPlike Active DFGin 5.8108 14.7141 BLAminus -124.15, 169.14 66.07, 88.5 -100.57, 30.98 280.35, 66.41 -65.35, -25.12 in-in in 9.5223 Saltbr-in 2.8826 HRD-in -85.83, -52.95 73.29, 9.38 in-in-in SNCiii in-in ActLoopNT-in 2.8514 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.93, 165.57 APE9-dihe-na 117.74, 172.78 APE8-dihe-in -83.6, 129.51 APE8-rot-in 307.46 APE67-dihe-in -66.9, -19.23 -49.63, -41.3 APE12-dist-in 8.2348 APE11-dist-in 11.5121 APE10-dist-in 6.0409 APE9-dist-in 4.269 None TPO517 TPO517 XRAY 1.83 0.188 0.215 A 347.0 336.0 0 27 27 0 [[360, 619]] 1.0 6bg2 Homo sapiens AGC_PRKG1_HUMAN AGC 2.6e-84 288.3 1.0 260.0 260.0 501 502 503 505 507 390 409 413 481 483 482 484.0 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 6BG2B Q13976 346 671 671.0 ANP:700 ATPlike Active DFGin 6.0006 13.8103 BLAminus -122.67, 175.58 65.94, 84.43 -99.77, 30.78 285.96, 70.42 -64.93, -24.07 in-in in 8.944 Saltbr-in 2.7425 HRD-in -86.95, -52.47 73.99, 7.96 in-in-in SNCiii in-in ActLoopNT-in 2.9238 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.61, 163.67 APE9-dihe-na 118.96, 172.39 APE8-dihe-in -86.94, 131.94 APE8-rot-in 306.51 APE67-dihe-in -68.79, -20.88 -48.58, -41.68 APE12-dist-in 7.8257 APE11-dist-in 11.2147 APE10-dist-in 5.7688 APE9-dist-in 4.0083 None TPO517 TPO517 XRAY 1.83 0.188 0.215 B 347.0 326.0 0 27 27 0 [[360, 619]] 1.0 6bg2 Homo sapiens AGC_PRKG1_HUMAN AGC 2.6e-84 288.3 1.0 260.0 260.0 501 502 503 505 507 390 409 413 481 483 482 484.0 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 6BG2C Q13976 337 671 671.0 ANP:700 ATPlike Active DFGin 5.7459 14.0572 BLAminus -122.99, 175.03 65.66, 84.22 -99.61, 30.7 281.62, 66.26 -64.81, -23.57 in-in in 8.7415 Saltbr-in 2.7233 HRD-in -85.99, -53.51 74.31, 7.4 in-in-in SNCiii in-in ActLoopNT-in 2.9506 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.66, 165.85 APE9-dihe-na 118.46, 173.18 APE8-dihe-in -87.41, 130.75 APE8-rot-in 306.63 APE67-dihe-in -67.71, -19.03 -48.39, -42.55 APE12-dist-in 7.9723 APE11-dist-in 11.3847 APE10-dist-in 5.8567 APE9-dist-in 3.8612 None TPO517 TPO517 XRAY 1.83 0.188 0.215 C 347.0 335.0 0 27 27 0 [[360, 619]] 1.0 6bg2 Homo sapiens AGC_PRKG1_HUMAN AGC 2.6e-84 288.3 1.0 260.0 260.0 501 502 503 505 507 390 409 413 481 483 482 484.0 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 6BG2D Q13976 344 671 671.0 ANP:700 ATPlike Active DFGin 5.7098 14.0124 BLAminus -124.49, 174.79 65.67, 84.87 -99.37, 30.45 283.38, 66.11 -64.13, -22.3 in-in in 8.754 Saltbr-in 2.6441 HRD-in -85.68, -52.69 74.16, 8.99 in-in-in SNCiii in-in ActLoopNT-in 2.9303 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.92, 166.42 APE9-dihe-na 119.53, 169.97 APE8-dihe-in -84.81, 130.45 APE8-rot-in 305.19 APE67-dihe-in -66.29, -19.88 -48.13, -43.31 APE12-dist-in 7.9878 APE11-dist-in 11.3267 APE10-dist-in 5.7839 APE9-dist-in 3.8102 None TPO517 TPO517 XRAY 1.83 0.188 0.215 D 347.0 328.0 0 27 27 0 [[360, 619]] 1.0 6bg2 Homo sapiens AGC_PRKG1_HUMAN AGC 2.6e-84 288.3 1.0 260.0 260.0 501 502 503 505 507 390 409 413 481 483 482 484.0 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7LV3A Q13976 57 671 671.0 ANP:60803 ATPlike Active DFGin 5.8509 14.0363 BLAminus -116.97, 177.04 63.26, 88.72 -106.87, 28.72 283.22, 63.7 -62.95, -24.33 in-in in 8.6241 Saltbr-in 2.891 HRD-in -87.82, -54.22 74.26, 7.32 in-in-in SNCiii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.28, 149.98 APE9-dihe-na 157.95, -145.59 APE8-dihe-in -124.73, 128.61 APE8-rot-in 299.79 APE67-dihe-in -58.37, -20.06 -47.89, -51.97 APE12-dist-in 7.9724 APE11-dist-in 11.0568 APE10-dist-in 5.4693 APE9-dist-in 3.8106 None TPO517 TPO517 XRAY 2.41 0.201 0.238 A 617.0 600.0 0 27 27 0 [[360, 619]] 1.0 7lv3 Homo sapiens AGC_PRKG1_HUMAN AGC 1.3e-83 286.3 1.0 260.0 260.0 501 502 503 505 507 390 409 413 481 483 482 484.0 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7LV3B Q13976 58 671 671.0 ANP:60803 ATPlike Active DFGin 5.6336 13.9624 BLAminus -116.52, 178.28 63.3, 90.17 -108.68, 29.08 283.48, 65.02 -62.88, -23.93 in-in in 8.8833 Saltbr-in 2.8237 HRD-in -86.48, -52.9 74.97, 7.4 in-in-in SNCiii in-in ActLoopNT-in 2.9589 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.28, 149.21 APE9-dihe-na 157.62, -145.94 APE8-dihe-in -123.75, 129.22 APE8-rot-in 300.73 APE67-dihe-in -59.05, -19.44 -46.41, -52.49 APE12-dist-in 8.1341 APE11-dist-in 11.1978 APE10-dist-in 5.6042 APE9-dist-in 3.7871 None TPO517 TPO517 XRAY 2.41 0.201 0.238 B 617.0 593.0 0 27 27 0 [[360, 619]] 1.0 7lv3 Homo sapiens AGC_PRKG1_HUMAN AGC 1.3e-83 286.3 1.0 260.0 260.0 501 502 503 505 507 390 409 413 481 483 482 484.0 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC ROCK1 ROCK1_HUMAN 2V55A Q13464 6 404 1354.0 ANP:1480 ATPlike Active DFGin 5.8805 13.604 BLAminus -137.29, -177.31 60.22, 109.9 -132.74, 24.25 290.89, 71.12 -53.92, -52.21 in-in in 9.0764 Saltbr-in 2.7079 HRD-in -79.75, -71.28 93.49, -31.37 in-in-in SNCiii in-in ActLoopNT-in 3.2811 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.46, 139.75 APE9-dihe-na 103.51, 160.5 APE8-dihe-in -55.22, 144.8 APE8-rot-in 285.63 APE67-dihe-in -74.86, -38.79 -80.34, -13.24 APE12-dist-in 10.3243 APE11-dist-in 11.2781 APE10-dist-in 5.6467 APE9-dist-in 4.1313 None None None XRAY 3.705 0.238 0.269 A 406.0 393.0 0 29 29 0 [[76, 338]] 1.0 2v55 Homo sapiens AGC_ROCK1_HUMAN AGC 3.3e-94 320.8 1.0 260.0 260.0 215 216 217 219 221 105 124 128 195 197 196 198.0 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 2V55C Q13464 6 404 1354.0 ANP:1480 ATPlike Active DFGin 5.8838 13.6079 BLAminus -137.56, -177.44 62.15, 108.48 -130.26, 22.71 291.3, 72.92 -54.95, -50.69 in-in in 9.1112 Saltbr-in 2.7059 HRD-in -78.29, -71.79 95.11, -31.46 in-in-in SNCiii in-in ActLoopNT-in 3.2466 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.41, 139.12 APE9-dihe-na 103.28, 159.31 APE8-dihe-in -53.48, 142.5 APE8-rot-in 287.35 APE67-dihe-in -76.24, -37.92 -78.8, -11.99 APE12-dist-in 10.2795 APE11-dist-in 11.2692 APE10-dist-in 5.6233 APE9-dist-in 4.0966 None None None XRAY 3.705 0.238 0.269 C 406.0 396.0 0 29 29 0 [[76, 338]] 1.0 2v55 Homo sapiens AGC_ROCK1_HUMAN AGC 3.3e-94 320.8 1.0 260.0 260.0 215 216 217 219 221 105 124 128 195 197 196 198.0 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC RPS6KA1-1 KS6A1_HUMAN 8XOVA Q15418 56 340 735.0 ANP:401 ATPlike Inactive DFGin 9.5319 13.1202 BLAplus -128.25, 170.81 61.53, 44.51 -100.37, -14.37 34.15, 82.03 -83.22, -24.55 out-out out 11.1338 Saltbr-out 8.8974 HRD-in -75.5, -43.57 69.32, -59.52 out-out-out SNCooo out-out ActLoopNT-out 9.5095 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioo APE10-dihe-na -98.67, 154.58 APE9-dihe-na -175.48, 178.84 APE8-dihe-in -87.06, 119.03 APE8-rot-in 310.44 APE67-dihe-in -48.48, -27.39 -73.46, -38.49 APE12-dist-none 999.0 APE11-dist-in 10.4198 APE10-dist-out 11.5117 APE9-dist-out 7.6388 None None None XRAY 2.55 0.206 0.252 A 321.0 261.0 24 28 19 9 [[62, 321], [418, 675]] 2.0 8xov Homo sapiens AGC_RPS6KA1-1_HUMAN AGC 1.5e-95 325.1 1.0 260.0 260.0 204 205 206 208 210 94 112 116 184 186 185 187.0 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOA P51812 45 348 740.0 ANP:401 ATPlike Inactive DFGin 5.6399 11.2827 None -75.51, -9.72 -147.12, 169.74 -135.13, 44.64 43.61, 79.33 88.97, 14.8 none-none none 999.0 Saltbr-none 999.0 HRD-in -69.31, -36.27 72.22, -63.18 none-out-out SNCnoo out-out ActLoopNT-out 10.019 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.25 APE8-rot-out 57.51 APE67-dihe-in -58.48, -32.95 -79.53, -17.69 APE12-dist-out 16.1812 APE11-dist-out 18.8341 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 A 317.0 295.0 9 28 26 2 [[68, 327], [422, 679]] 2.0 7opo Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOE P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGin 5.8283 11.217 None -75.62, -9.94 -146.57, 168.73 -137.15, 44.22 42.0, 80.75 88.39, 15.03 none-none none 999.0 Saltbr-none 999.0 HRD-in -66.39, -31.42 74.68, -62.95 none-out-out SNCnoo out-out ActLoopNT-out 10.1321 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 163.55 APE8-rot-out 177.27 APE67-dihe-in -61.67, -34.26 -80.52, -22.56 APE12-dist-out 16.151 APE11-dist-out 17.6928 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 E 317.0 293.0 10 28 26 2 [[68, 327], [422, 679]] 2.0 7opo Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOI P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGin 5.7417 11.3154 None -74.55, -8.16 -143.05, 166.95 -136.59, 41.95 46.16, 81.46 88.21, 13.52 none-none none 999.0 Saltbr-none 999.0 HRD-in -66.43, -31.99 74.45, -63.8 none-out-out SNCnoo out-out ActLoopNT-out 10.2243 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_onnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 118.34 APE8-rot-out 174.05 APE67-dihe-in -60.03, -34.02 -108.65, -14.12 APE12-dist-out 16.6879 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 I 317.0 292.0 11 28 25 3 [[68, 327], [422, 679]] 2.0 7opo Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOK P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGin 5.7434 11.0548 None -76.12, -10.81 -146.65, 168.53 -136.2, 45.6 41.69, 77.26 88.29, 15.08 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.92, -32.34 73.01, -61.24 none-out-out SNCnoo out-out ActLoopNT-out 9.9521 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 7.45 APE8-rot-out 57.97 APE67-dihe-in -59.53, -34.14 -77.79, -20.27 APE12-dist-out 17.1175 APE11-dist-out 17.3774 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 K 317.0 293.0 10 28 26 2 [[68, 327], [422, 679]] 2.0 7opo Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOC P51812 46 347 740.0 ANP:401 ATPlike Inactive DFGinter 5.815 10.9932 None -75.13, -10.43 -146.35, 169.25 -135.79, 44.23 43.29, 81.79 87.07, 14.29 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.74, -32.6 74.07, -63.87 none-out-out SNCnoo out-out ActLoopNT-out 10.1655 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -61.13, 122.89 APE9-dihe-na 75.62, 166.95 APE8-dihe-in -113.03, 115.92 APE8-rot-out 46.3 APE67-dihe-in -62.7, -36.2 -57.15, -32.55 APE12-dist-out 16.3121 APE11-dist-out 16.9338 APE10-dist-out 13.4944 APE9-dist-out 6.8696 None None None XRAY 2.75 0.209 0.232 C 317.0 295.0 7 28 28 0 [[68, 327], [422, 679]] 2.0 7opo Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOG P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGinter 6.6797 10.9627 None -75.68, -10.29 -146.32, 168.68 -137.91, 45.72 44.25, 84.07 86.95, 15.93 out-out out 19.3384 Saltbr-out 19.7531 HRD-in -66.3, -31.74 74.35, -64.56 out-out-out SNCooo out-out ActLoopNT-out 10.1118 ActLoopCT-out nonTYR APEdihe_aanni APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 105.02 APE8-rot-none 999.0 APE67-dihe-in -58.75, -33.49 -86.55, -15.46 APE12-dist-out 16.9864 APE11-dist-out 17.7665 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 G 317.0 301.0 2 28 26 2 [[68, 327], [422, 679]] 2.0 7opo Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA6-1 KS6A6_HUMAN 6G77A Q9UK32 51 349 745.0 ANP:401,ANP:402 Allosteric,ATPlike Inactive DFGin 5.9835 11.2516 None -84.57, 1.64 -160.36, 173.95 -140.73, 41.08 33.77, 88.9 86.89, 20.77 none-none none 999.0 Saltbr-none 999.0 HRD-in -75.55, -32.96 78.36, -52.1 none-out-out SNCnoo out-out ActLoopNT-out 9.9576 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 55.72, -148.34 APE9-dihe-na -103.74, -158.66 APE8-dihe-in -91.11, 113.9 APE8-rot-in 297.76 APE67-dihe-in -53.19, -20.32 -55.54, -41.19 APE12-dist-in 13.7321 APE11-dist-out 15.8714 APE10-dist-out 13.5037 APE9-dist-in 5.5319 None None None XRAY 2.499 0.188 0.233 A 307.0 291.0 8 28 28 0 [[73, 330], [426, 683]] 2.0 6g77 Homo sapiens AGC_RPS6KA6-1_HUMAN AGC 1.1e-97 332.1 1.0 260.0 260.0 215 216 217 219 221 105 123 127 195 197 196 198.0 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G77B Q9UK32 51 349 745.0 ANP:401,ANP:402 Allosteric,ATPlike Inactive DFGin 5.612 11.3114 None -84.74, -2.79 -145.41, 176.89 -143.69, 39.64 45.89, 82.52 94.84, 15.56 none-none none 999.0 Saltbr-none 999.0 HRD-in -77.95, -30.79 74.87, -47.1 none-out-out SNCnoo out-out ActLoopNT-out 10.0706 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 55.75, -144.28 APE9-dihe-na -119.2, -153.74 APE8-dihe-in -83.74, 120.03 APE8-rot-in 297.54 APE67-dihe-in -52.98, -34.42 -57.71, -42.71 APE12-dist-in 13.9149 APE11-dist-out 16.0857 APE10-dist-out 13.633 APE9-dist-in 5.5223 None None None XRAY 2.499 0.188 0.233 B 307.0 291.0 8 28 28 0 [[73, 330], [426, 683]] 2.0 6g77 Homo sapiens AGC_RPS6KA6-1_HUMAN AGC 1.1e-97 332.1 1.0 260.0 260.0 215 216 217 219 221 105 123 127 195 197 196 198.0 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G76B Q9UK32 51 349 745.0 ANP:401 ATPlike Inactive DFGinter 5.7966 10.9823 None -66.14, -24.76 -146.8, 171.15 -130.39, 64.5 31.65, 91.02 69.21, 34.12 none-none none 999.0 Saltbr-none 999.0 HRD-in -64.7, -28.83 65.1, -58.97 none-out-none SNCnon out-none ActLoopNT-out 9.714 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -65.75, -19.3 999.0, -17.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP232 SEP232 XRAY 3.0 0.226 0.268 B 307.0 269.0 30 28 17 11 [[73, 330], [426, 683]] 2.0 6g76 Homo sapiens AGC_RPS6KA6-1_HUMAN AGC 1.1e-97 332.1 1.0 260.0 260.0 215 216 217 219 221 105 123 127 195 197 196 198.0 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G78A Q9UK32 51 349 745.0 ANP:401 ATPlike Inactive DFGinter 6.2685 10.6336 None -86.41, -10.47 -141.48, -170.45 -156.88, 52.15 42.27, 88.32 84.48, 16.59 none-none none 999.0 Saltbr-none 999.0 HRD-in -69.26, -28.88 63.94, -61.25 none-out-out SNCnoo out-out ActLoopNT-out 9.5896 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 82.23 APE8-dihe-out 57.69, 79.35 APE8-rot-in 324.77 APE67-dihe-in -47.93, -24.91 -65.59, -33.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 7.9125 S232E None None XRAY 2.5 0.227 0.24 A 307.0 283.0 16 28 20 8 [[73, 330], [426, 683]] 2.0 6g78 Homo sapiens AGC_RPS6KA6-1_HUMAN AGC 1.4e-97 331.8 1.0 260.0 260.0 215 216 217 219 221 105 123 127 195 197 196 198.0 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G78B Q9UK32 51 349 745.0 ANP:401 ATPlike Inactive DFGinter 5.64 10.7376 None -79.92, -10.17 -139.49, -179.53 -146.16, 53.91 40.8, 75.5 84.23, 17.04 none-none none 999.0 Saltbr-none 999.0 HRD-in -71.51, -26.87 55.09, -79.87 none-out-out SNCnoo out-out ActLoopNT-out 9.8393 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -162.93 APE8-dihe-in -60.6, 118.59 APE8-rot-in 321.37 APE67-dihe-in -66.02, -21.47 -64.56, -33.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.8452 S232E None None XRAY 2.5 0.227 0.24 B 307.0 281.0 18 28 18 10 [[73, 330], [426, 683]] 2.0 6g78 Homo sapiens AGC_RPS6KA6-1_HUMAN AGC 1.4e-97 331.8 1.0 260.0 260.0 215 216 217 219 221 105 123 127 195 197 196 198.0 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G76A Q9UK32 51 349 745.0 ANP:401,ANP:402 ATPlike,Allosteric Inactive DFGinter 6.2614 10.8766 None -85.39, -13.66 -143.61, 178.12 -143.21, 50.96 33.86, 88.85 75.03, 27.38 none-none none 999.0 Saltbr-none 999.0 HRD-in -70.26, -5.92 45.43, -59.01 none-out-out SNCnoo out-out ActLoopNT-out 9.8423 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 52.64, -135.92 APE9-dihe-na -103.88, -148.96 APE8-dihe-in -100.12, 127.8 APE8-rot-in 306.8 APE67-dihe-in -56.57, -28.02 -70.04, -37.97 APE12-dist-in 13.9093 APE11-dist-out 16.2474 APE10-dist-out 12.7459 APE9-dist-in 5.5959 None SEP232 SEP232 XRAY 3.0 0.226 0.268 A 307.0 291.0 8 28 28 0 [[73, 330], [426, 683]] 2.0 6g76 Homo sapiens AGC_RPS6KA6-1_HUMAN AGC 1.1e-97 332.1 1.0 260.0 260.0 215 216 217 219 221 105 123 127 195 197 196 198.0 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC SGK1 SGK1_HUMAN 2R5TA O00141 82 378 431.0 ANP:500 ATPlike Inactive DFGinter 10.2486 5.7396 None -86.79, -16.14 -72.2, 135.26 -125.95, 20.0 58.26, 94.07 102.37, 6.12 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.44, -44.78 83.3, -51.0 none-out-out SNCnoo out-out ActLoopNT-out 9.2434 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na 54.74, 50.94 APE9-dihe-na -69.27, 152.13 APE8-dihe-in -51.76, 128.99 APE8-rot-in 305.39 APE67-dihe-out -166.98, 160.95 -53.6, 132.16 APE12-dist-out 29.8831 APE11-dist-out 30.6496 APE10-dist-out 28.0339 APE9-dist-out 16.2479 S74A,S78A,S397A,S401A None None XRAY 1.9 0.193 0.215 A 373.0 284.0 13 28 28 0 [[98, 355]] 1.0 2r5t Homo sapiens AGC_SGK1_HUMAN AGC 4.6e-99 336.7 1.0 260.0 260.0 239 240 241 243 245 127 146 150 219 221 220 222.0 279 267 262 261 260 259 258 257 256 177 Serine/threonine-protein kinase Sgk1
AGC STK38 STK38_HUMAN 6BXIA Q15208 82 414 465.0 ANP:501 ATPlike Inactive DFGin 7.6243 15.2423 None -66.11, 165.54 -58.06, 132.91 -140.43, 160.91 66.01, 93.84 127.58, -39.07 out-out out 17.2238 Saltbr-out 15.8035 HRD-out -81.74, 95.52 -90.45, 26.47 out-out-out SNCooo out-out ActLoopNT-out 8.4633 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -99.6, -60.62 APE9-dihe-na 67.05, -156.06 APE8-dihe-in -145.17, 163.6 APE8-rot-out 65.89 APE67-dihe-in -50.28, -35.19 -91.75, 25.88 APE12-dist-out 17.3379 APE11-dist-out 14.2084 APE10-dist-out 17.7703 APE9-dist-out 12.1009 None None None XRAY 2.2 0.173 0.212 A 333.0 333.0 0 63 63 0 [[89, 382]] 1.0 6bxi Homo sapiens AGC_STK38_HUMAN AGC 2.8e-98 334.1 1.0 260.0 260.0 229 230 231 233 235 118 137 141 209 211 210 212.0 304 292 287 286 285 284 283 282 281 167 Serine/threonine-protein kinase 38
AGC STK38 STK38_HUMAN 6BXIB Q15208 83 414 465.0 ANP:501 ATPlike Inactive DFGin 7.5828 15.1791 None -72.08, 165.13 -53.35, 130.13 -138.87, 159.98 66.77, 96.29 126.01, -39.3 out-out out 17.1655 Saltbr-out 16.0645 HRD-out -84.3, 107.68 -100.32, 27.31 out-out-out SNCooo out-out ActLoopNT-out 8.4877 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -97.07, -63.08 APE9-dihe-na 73.07, -157.98 APE8-dihe-in -144.12, 160.82 APE8-rot-out 65.98 APE67-dihe-in -53.15, -35.39 -88.29, 27.93 APE12-dist-out 17.2389 APE11-dist-out 14.1835 APE10-dist-out 17.7413 APE9-dist-out 12.0524 None None None XRAY 2.2 0.173 0.212 B 333.0 332.0 0 63 63 0 [[89, 382]] 1.0 6bxi Homo sapiens AGC_STK38_HUMAN AGC 2.8e-98 334.1 1.0 260.0 260.0 229 230 231 233 235 118 137 141 209 211 210 212.0 304 292 287 286 285 284 283 282 281 167 Serine/threonine-protein kinase 38
CAMK AURKA AURKA_HUMAN 2DWBA O14965 126 389 403.0 ANP:502 ATPlike Inactive DFGin 5.6048 15.1145 BLAminus -136.11, 177.41 60.85, 78.38 -89.15, 29.26 286.88, 68.88 -66.25, -4.03 in-in in 9.2398 Saltbr-in 3.1689 HRD-in -70.6, -46.07 60.68, 4.1 in-in-out SNCiio in-out ActLoopNT-in 3.0356 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -134.99, -178.03 APE9-dihe-na -132.27, -116.26 APE8-dihe-in -79.37, 134.9 APE8-rot-out 179.73 APE67-dihe-in -26.2, -44.84 -85.0, -15.78 APE12-dist-in 8.0361 APE11-dist-in 12.1391 APE10-dist-out 11.1616 APE9-dist-out 10.8267 None None MSE300,MSE305,MSE373 XRAY 2.5 0.227 0.275 A 285.0 262.0 2 26 24 2 [[133, 383]] 1.0 2dwb Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPGA O14965 7 389 403.0 ANP:60401 ATPlike Active DFGin 5.3184 15.0701 BLAminus -133.54, 176.05 56.91, 81.54 -90.61, 23.9 286.39, 75.22 -62.73, -9.76 in-in in 9.8844 Saltbr-in 2.9538 HRD-in -72.51, -51.0 67.55, 11.3 in-in-in SNCiii in-in ActLoopNT-in 3.0433 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.96, 159.16 APE9-dihe-na 122.67, -152.53 APE8-dihe-in -117.94, 146.39 APE8-rot-in 309.68 APE67-dihe-in -61.83, -12.97 -52.19, -62.88 APE12-dist-in 8.5172 APE11-dist-in 11.4274 APE10-dist-in 5.7242 APE9-dist-in 3.8329 None TPO287,TPO288 TPO287,TPO288 XRAY 2.64 0.204 0.245 A 292.0 267.0 0 26 26 0 [[133, 383]] 1.0 6vpg Homo sapiens CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPIA O14965 104 389 403.0 ANP:60601 ATPlike Inactive DFGin 5.4078 15.3189 BLAminus -130.78, 176.39 58.02, 80.51 -93.54, 25.65 284.58, 75.71 -64.44, -24.62 in-in in 9.8845 Saltbr-in 3.1969 HRD-in -68.95, -50.99 70.99, 3.21 in-in-out SNCiio in-out ActLoopNT-in 2.8207 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -142.04, 146.83 APE9-dihe-na 91.87, 167.2 APE8-dihe-in -74.18, 122.94 APE8-rot-in 319.25 APE67-dihe-in -55.59, -26.7 -100.93, -9.45 APE12-dist-in 10.0099 APE11-dist-in 12.8345 APE10-dist-out 16.1495 APE9-dist-out 20.0557 None None None XRAY 2.0 0.188 0.215 A 292.0 264.0 0 26 26 0 [[133, 383]] 1.0 6vpi Homo sapiens CAMK_AURKA_HUMAN CAMK 6.9e-78 267.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPLA O14965 7 389 403.0 ANP:60602,R7D:60606 ATPlike,Allosteric Inactive DFGin 5.4712 15.7016 BLAminus -128.47, 179.47 64.6, 81.81 -95.02, 21.48 283.88, 78.68 -63.38, -17.61 out-out out 10.4098 Saltbr-out 4.4992 HRD-in -80.46, -54.34 74.63, 5.06 out-in-out SNCoio in-out ActLoopNT-in 2.9665 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -88.44, -6.25 APE9-dihe-na -62.06, -23.8 APE8-dihe-in -134.19, 108.37 APE8-rot-in 311.29 APE67-dihe-in -61.89, -28.27 -86.38, -9.29 APE12-dist-out 25.8944 APE11-dist-out 21.3249 APE10-dist-out 23.1598 APE9-dist-out 28.0042 None TPO288 TPO288 XRAY 1.86 0.169 0.201 A 292.0 262.0 4 26 22 4 [[133, 383]] 1.0 6vpl Homo sapiens CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPLB O14965 7 389 403.0 ANP:60601,R7D:60605 ATPlike,Allosteric Inactive DFGin 5.5835 16.0448 BLAminus -127.84, 176.75 65.51, 80.18 -93.8, 23.88 286.09, 77.69 -67.93, -15.19 out-out out 10.6562 Saltbr-out 4.5577 HRD-in -79.97, -52.06 71.02, 4.97 out-in-out SNCoio in-out ActLoopNT-in 2.9438 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -84.27, -7.56 APE9-dihe-na -59.65, -24.89 APE8-dihe-in -135.15, 99.87 APE8-rot-in 315.26 APE67-dihe-in -58.26, -30.91 -76.18, -13.07 APE12-dist-out 25.8592 APE11-dist-out 21.4014 APE10-dist-out 23.5627 APE9-dist-out 28.2448 None TPO288 TPO288 XRAY 1.86 0.169 0.201 B 292.0 262.0 4 26 22 4 [[133, 383]] 1.0 6vpl Homo sapiens CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2C6DA O14965 126 390 403.0 ANP:61391 ATPlike Inactive DFGin 6.2574 16.4224 None -70.12, 150.14 -40.51, 101.21 -55.1, 131.85 61.77, 102.87 98.63, -164.78 out-out out 13.1601 Saltbr-out 13.9978 HRD-out -91.98, 166.93 -128.47, 87.17 out-out-out SNCooo out-out ActLoopNT-out 17.9333 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 134.8 APE8-dihe-in -71.63, 167.98 APE8-rot-out 60.54 APE67-dihe-in -57.74, -18.95 -51.64, -36.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.0437 None None None XRAY 2.2 0.23 0.28 A 275.0 255.0 10 26 16 10 [[133, 383]] 1.0 2c6d Homo sapiens CAMK_AURKA_HUMAN CAMK 1.5e-79 272.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPJA O14965 104 389 403.0 ANP:60401 ATPlike Inactive DFGout 12.8705 10.5737 None -110.21, 156.22 -91.65, 36.01 -66.52, 152.83 298.69, 154.8 77.13, 20.04 out-out out 11.1099 Saltbr-out 9.2857 HRD-out -138.11, 171.42 -106.7, -171.48 out-out-out SNCooo out-out ActLoopNT-out 12.6593 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -97.02, 1.42 APE9-dihe-na 78.4, 140.83 APE8-dihe-out -96.06, -166.39 APE8-rot-out 60.44 APE67-dihe-in -59.33, -27.82 -96.84, 6.17 APE12-dist-in 11.6479 APE11-dist-in 13.2558 APE10-dist-out 10.9109 APE9-dist-out 17.2151 None None None XRAY 2.1 0.192 0.215 A 292.0 263.0 3 26 23 3 [[133, 383]] 1.0 6vpj Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPHA O14965 7 389 403.0 ANP:60604 ATPlike Inactive DFGout 13.6713 11.5565 None -98.71, -169.93 -135.39, 50.18 -66.9, 153.36 295.81, 141.3 65.48, 29.39 out-out out 11.3786 Saltbr-out 9.7752 HRD-out -105.53, 132.54 -112.81, 142.85 out-out-out SNCooo out-out ActLoopNT-out 14.5801 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na -129.35, -34.6 APE9-dihe-na -51.22, -37.08 APE8-dihe-out -65.53, -18.81 APE8-rot-out 65.19 APE67-dihe-in -56.69, -28.96 -65.95, -34.72 APE12-dist-out 14.7601 APE11-dist-in 9.582 APE10-dist-out 12.2573 APE9-dist-out 21.2222 None TPO287,TPO288 CAS247,TPO287,TPO288,CAS290 XRAY 2.14 0.189 0.216 A 292.0 267.0 0 26 26 0 [[133, 383]] 1.0 6vph Homo sapiens CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK CASK CSKP_HUMAN 3MFRA O14936 5 306 926.0 ANP:500 ATPlike Pseudo DFGin 7.2881 14.824 BLAminus -130.01, -163.55 44.45, 79.28 -92.76, 26.16 280.97, 75.37 -59.27, -25.64 in-in in 9.5023 Saltbr-in 2.7988 HRD-in -78.83, -45.71 73.64, -1.18 in-in-in SNCiii in-in ActLoopNT-in 2.9977 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.41, 141.74 APE9-dihe-na 116.11, -155.43 APE8-dihe-in -114.21, 120.95 APE8-rot-in 305.84 APE67-dihe-in -66.35, -20.44 -39.68, -44.71 APE12-dist-in 11.9872 APE11-dist-in 12.4034 APE10-dist-in 6.658 APE9-dist-in 3.5931 P22A,H145E,C146N,G162D None None XRAY 2.0 0.198 0.241 A 351.0 302.0 0 28 28 0 [[12, 276]] 1.0 3mfr Homo sapiens CAMK_CASK_HUMAN CAMK 2.4e-85 291.9 1.0 256.0 256.0 161 162 163 165 167 41 62 66 138 140 139 141.0 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3MFSA O14936 4 306 926.0 ANP:500 ATPlike Pseudo DFGin 7.1207 14.9168 BLAminus -132.54, -159.47 54.72, 71.28 -90.49, 27.88 285.64, 73.35 -63.01, -24.88 in-in in 9.8552 Saltbr-in 3.2557 HRD-in -74.69, -45.24 69.87, -1.37 in-in-in SNCiii in-in ActLoopNT-in 2.8764 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.15, 142.33 APE9-dihe-na 119.56, -149.24 APE8-dihe-in -110.99, 115.07 APE8-rot-in 303.42 APE67-dihe-in -55.02, -32.56 -38.77, -44.89 APE12-dist-in 12.0849 APE11-dist-in 12.3002 APE10-dist-in 6.637 APE9-dist-in 3.6341 P22A,H145E,C146N,G162D None None XRAY 2.1 0.221 0.268 A 351.0 303.0 0 28 28 0 [[12, 276]] 1.0 3mfs Homo sapiens CAMK_CASK_HUMAN CAMK 2.4e-85 291.9 1.0 256.0 256.0 161 162 163 165 167 41 62 66 138 140 139 141.0 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3MFUA O14936 5 306 926.0 ANP:500 ATPlike Pseudo DFGin 7.162 14.9785 BLAminus -132.46, -169.21 51.97, 75.16 -95.02, 30.45 283.47, 72.96 -64.45, -32.11 in-in in 9.4389 Saltbr-in 3.2062 HRD-in -76.17, -45.52 71.72, -5.88 in-in-in SNCiii in-in ActLoopNT-in 2.8233 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.79, 142.93 APE9-dihe-na 117.49, -160.73 APE8-dihe-in -102.18, 121.4 APE8-rot-in 298.46 APE67-dihe-in -63.89, -19.89 -44.81, -44.73 APE12-dist-in 12.0842 APE11-dist-in 12.1946 APE10-dist-in 6.4485 APE9-dist-in 3.7371 P22A,H145E,C146N,G162D None None XRAY 2.3 0.182 0.234 A 351.0 302.0 0 28 28 0 [[12, 276]] 1.0 3mfu Homo sapiens CAMK_CASK_HUMAN CAMK 2.4e-85 291.9 1.0 256.0 256.0 161 162 163 165 167 41 62 66 138 140 139 141.0 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 9M6GA O14936 5 312 926.0 ANP:401 ATPlike Pseudo DFGin 7.4525 15.1144 BLAminus -123.77, -152.06 75.54, 37.97 -87.68, 22.87 280.47, 84.05 -71.57, -12.61 in-in in 9.6001 Saltbr-in 2.8974 HRD-in -79.25, -45.64 76.25, -8.72 in-in-in SNCiii in-in ActLoopNT-in 2.9758 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.23, 151.66 APE9-dihe-na 106.36, -155.68 APE8-dihe-in -120.97, 120.76 APE8-rot-in 297.98 APE67-dihe-in -62.79, -20.16 -47.6, -44.68 APE12-dist-in 12.4198 APE11-dist-in 12.2151 APE10-dist-in 6.6498 APE9-dist-in 3.6453 None None None XRAY 1.7 0.167 0.187 A 325.0 308.0 0 28 28 0 [[12, 276]] 1.0 9m6g Homo sapiens CAMK_CASK_HUMAN CAMK 4.9e-82 281.1 1.0 256.0 256.0 161 162 163 165 167 41 62 66 138 140 139 141.0 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 9M5YA O14936 3 312 926.0 ANP:401 ATPlike Pseudo DFGin 7.7139 15.5119 BLAminus -121.67, -150.51 71.79, 35.46 -86.15, 22.59 279.83, 82.24 -67.65, -16.3 in-in in 9.9588 Saltbr-in 2.8667 HRD-in -79.78, -48.63 75.37, -2.97 in-in-in SNCiii in-in ActLoopNT-in 3.0122 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.65, 147.9 APE9-dihe-na 109.7, -155.33 APE8-dihe-in -121.16, 120.88 APE8-rot-in 298.99 APE67-dihe-in -58.84, -21.41 -46.45, -46.8 APE12-dist-in 12.6873 APE11-dist-in 12.2786 APE10-dist-in 6.8567 APE9-dist-in 3.5925 None None None XRAY 1.8 0.168 0.197 A 338.0 310.0 0 28 28 0 [[12, 276]] 1.0 9m5y Homo sapiens CAMK_CASK_HUMAN CAMK 5.6e-82 280.9 1.0 256.0 256.0 161 162 163 165 167 41 62 66 138 140 139 141.0 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CHEK1 CHK1_HUMAN 5OOPA O14757 5 271 476.0 ANP:301 ATPlike Inactive DFGin 7.0477 13.8582 BLAminus -117.87, 168.06 78.81, 84.96 -99.9, 22.77 292.72, 82.66 -69.65, -23.48 in-out in 9.5919 Saltbr-out 3.6686 HRD-in -77.29, -47.33 77.92, -0.19 out-in-in SNCoii in-in ActLoopNT-in 2.8937 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.46, 169.24 APE9-dihe-na 115.98, -146.93 APE8-dihe-in -135.24, 119.66 APE8-rot-in 302.63 APE67-dihe-in -65.46, -19.69 -46.47, -46.68 APE12-dist-in 8.8885 APE11-dist-in 11.8345 APE10-dist-in 6.194 APE9-dist-in 3.4741 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.7 0.159 0.197 A 297.0 261.0 6 30 30 0 [[9, 265]] 1.0 5oop Homo sapiens CAMK_CHEK1_HUMAN CAMK 4.8e-69 238.4 2.0 256.0 255.0 147 148 149 151 153 38 55 59 127 129 128 130.0 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK DAPK1 DAPK1_HUMAN 1IG1A P53355 2 294 1430.0 ANP:300 ATPlike Inactive DFGin 6.604 13.9088 BLAminus -125.04, -172.1 54.91, 85.1 -99.27, 28.4 288.12, 76.24 -63.74, -23.2 in-in in 9.031 Saltbr-in 2.7496 HRD-in -78.58, -44.7 65.96, 3.14 in-in-out SNCiio in-out ActLoopNT-in 2.921 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -151.68, 130.77 APE9-dihe-na -110.11, -140.22 APE8-dihe-in -82.02, 119.3 APE8-rot-in 301.63 APE67-dihe-in -57.96, -29.17 -38.12, -46.81 APE12-dist-in 11.7974 APE11-dist-out 6.5642 APE10-dist-out 9.4133 APE9-dist-in 4.7364 None None None XRAY 1.8 0.19 0.213 A 294.0 280.0 0 27 27 0 [[13, 275]] 1.0 1ig1 Homo sapiens CAMK_DAPK1_HUMAN CAMK 6.1e-95 323.3 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 1JKKA P53355 2 293 1430.0 ANP:300 ATPlike Inactive DFGin 6.7835 14.1245 BLAminus -129.05, -171.64 53.69, 79.96 -93.76, 28.82 285.99, 76.67 -62.99, -25.8 in-in in 9.0833 Saltbr-in 2.8517 HRD-in -75.07, -48.19 66.55, 3.19 in-in-out SNCiio in-out ActLoopNT-in 2.8179 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -147.0, 130.95 APE9-dihe-na -112.64, -140.24 APE8-dihe-in -81.46, 116.94 APE8-rot-in 307.06 APE67-dihe-in -60.31, -32.99 -34.91, -46.77 APE12-dist-in 11.7828 APE11-dist-out 6.5798 APE10-dist-out 9.4627 APE9-dist-in 4.7757 None None None XRAY 2.4 0.204 0.239 A 294.0 277.0 0 27 27 0 [[13, 275]] 1.0 1jkk Homo sapiens CAMK_DAPK1_HUMAN CAMK 6.1e-95 323.3 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 1JKLA P53355 2 294 1430.0 ANP:300 ATPlike Inactive DFGin 6.6953 14.0571 BLAminus -124.2, -176.99 56.35, 84.0 -97.94, 28.61 287.61, 72.21 -64.45, -19.09 in-in in 9.1382 Saltbr-in 2.7337 HRD-in -79.78, -44.18 66.54, 4.23 in-in-out SNCiio in-out ActLoopNT-in 2.9055 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -149.57, 122.41 APE9-dihe-na -98.92, -146.89 APE8-dihe-in -78.98, 121.07 APE8-rot-in 305.85 APE67-dihe-in -59.69, -24.46 -37.84, -49.7 APE12-dist-in 11.6855 APE11-dist-out 6.5935 APE10-dist-out 9.371 APE9-dist-in 4.3417 None None None XRAY 1.62 0.201 0.218 A 294.0 280.0 0 27 27 0 [[13, 275]] 1.0 1jkl Homo sapiens CAMK_DAPK1_HUMAN CAMK 6.1e-95 323.3 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3EHAA P53355 2 277 1430.0 ANP:60001 ATPlike Inactive DFGin 6.6434 13.968 BLAminus -119.49, -175.62 63.64, 76.35 -92.04, 24.1 287.15, 77.48 -66.02, -21.06 in-in in 9.1584 Saltbr-in 2.6922 HRD-in -77.77, -44.22 68.16, 6.09 in-in-out SNCiio in-out ActLoopNT-in 2.8879 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -154.08, 109.66 APE9-dihe-na -88.11, -145.31 APE8-dihe-in -81.75, 125.02 APE8-rot-in 299.42 APE67-dihe-in -58.59, -25.21 -48.84, -41.78 APE12-dist-in 11.4704 APE11-dist-out 6.0853 APE10-dist-out 9.2869 APE9-dist-in 4.2218 None None None XRAY 1.6 0.18 0.21 A 294.0 275.0 1 27 27 0 [[13, 275]] 1.0 3eha Homo sapiens CAMK_DAPK1_HUMAN CAMK 6.1e-95 323.3 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3F5UA P53355 2 277 1430.0 ANP:60296 ATPlike Inactive DFGin 6.6797 13.9947 BLAminus -122.58, -175.66 63.1, 76.98 -89.92, 20.62 285.03, 75.31 -66.71, -20.92 in-in in 9.0543 Saltbr-in 2.6882 HRD-in -78.22, -44.99 68.31, 7.38 in-in-out SNCiio in-out ActLoopNT-in 2.898 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -161.85, 115.62 APE9-dihe-na -94.87, -137.37 APE8-dihe-in -88.11, 123.84 APE8-rot-in 295.48 APE67-dihe-in -54.81, -31.05 -45.75, -45.06 APE12-dist-in 11.55 APE11-dist-out 6.1509 APE10-dist-out 9.3577 APE9-dist-in 4.6295 None None None XRAY 2.0 0.18 0.245 A 295.0 276.0 0 27 27 0 [[13, 275]] 1.0 3f5u Homo sapiens CAMK_DAPK1_HUMAN CAMK 6.2e-95 323.3 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3DFCB P53355 2 277 1430.0 ANP:60296 ATPlike Inactive DFGin 6.707 13.9525 BLAminus -118.29, -174.34 63.43, 75.59 -92.23, 26.78 286.33, 80.12 -73.39, -15.17 in-in in 8.9704 Saltbr-in 2.5266 HRD-in -81.02, -45.28 68.61, 4.35 in-in-out SNCiio in-out ActLoopNT-in 2.9376 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -159.6, 115.29 APE9-dihe-na -93.8, -150.98 APE8-dihe-in -71.52, 120.43 APE8-rot-in 314.5 APE67-dihe-in -56.35, -28.25 -48.91, -39.24 APE12-dist-in 10.0003 APE11-dist-out 6.5811 APE10-dist-out 9.2988 APE9-dist-in 4.2316 Q23K None None XRAY 1.9 0.168 0.23 B 295.0 276.0 0 27 27 0 [[13, 275]] 1.0 3dfc Homo sapiens CAMK_DAPK1_HUMAN CAMK 6.8e-95 323.2 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3GU4A P53355 2 277 1430.0 ANP:60296 ATPlike Inactive DFGin 6.6865 14.2032 BLAminus -120.75, -178.24 63.74, 79.48 -95.12, 25.33 287.4, 76.71 -69.42, -15.77 in-in in 9.1537 Saltbr-in 2.7549 HRD-in -78.17, -46.9 70.13, 2.93 in-in-out SNCiio in-out ActLoopNT-in 2.8929 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -151.92, 117.7 APE9-dihe-na -90.42, -152.95 APE8-dihe-in -78.93, 125.78 APE8-rot-in 285.84 APE67-dihe-in -58.94, -26.13 -43.12, -44.76 APE12-dist-in 9.9158 APE11-dist-out 6.6991 APE10-dist-out 9.3936 APE9-dist-in 4.1456 Q23V None None XRAY 1.35 0.185 0.211 A 295.0 276.0 0 27 27 0 [[13, 275]] 1.0 3gu4 Homo sapiens CAMK_DAPK1_HUMAN CAMK 2.1e-94 321.5 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3GU5A P53355 2 277 1430.0 ANP:60297 ATPlike Inactive DFGin 6.5951 14.0362 BLAminus -118.63, -175.92 62.35, 83.7 -99.02, 25.46 285.84, 80.17 -66.36, -22.17 in-in in 9.0755 Saltbr-in 2.7074 HRD-in -79.55, -44.61 67.36, 6.25 in-in-out SNCiio in-out ActLoopNT-in 2.938 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -153.43, 114.75 APE9-dihe-na -95.21, -137.89 APE8-dihe-in -89.62, 125.79 APE8-rot-in 297.58 APE67-dihe-in -53.19, -29.37 -44.73, -43.47 APE12-dist-in 11.313 APE11-dist-out 6.2799 APE10-dist-out 9.5719 APE9-dist-in 4.7553 Q23V None None XRAY 1.65 0.178 0.219 A 295.0 276.0 0 27 27 0 [[13, 275]] 1.0 3gu5 Homo sapiens CAMK_DAPK1_HUMAN CAMK 2.1e-94 321.5 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK MELK MELK_HUMAN 4BL1A Q14680 2 333 651.0 ANP:1000 ATPlike Inactive DFGin 6.3379 13.9347 ABAminus -114.35, -16.21 -125.02, 95.86 -105.85, 20.97 306.05, 72.32 -48.23, -28.35 in-in in 8.5656 Saltbr-in 2.6282 HRD-in -47.49, -61.71 83.33, 5.93 in-in-out SNCiio in-out ActLoopNT-in 3.0985 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 125.09 APE8-rot-out 166.93 APE67-dihe-in -51.79, -28.37 -37.56, -42.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.184 0.26 A 347.0 312.0 20 29 15 14 [[11, 263]] 1.0 4bl1 Homo sapiens CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK PIM1 PIM1_HUMAN 1YXTA P11309 33 306 313.0 ANP:322 ATPlike Active DFGin 6.0285 14.2451 BLAminus -131.81, 176.98 66.39, 83.69 -99.64, 19.64 287.53, 80.25 -65.72, -15.35 in-in in 8.3094 Saltbr-in 2.8936 HRD-naA -67.95, -50.18 66.45, 4.68 in-in-in SNCiii in-in ActLoopNT-in 2.8088 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.69, 12.99 APE9-dihe-na -80.03, -158.46 APE8-dihe-in -83.46, 121.7 APE8-rot-in 308.53 APE67-dihe-in -70.36, -3.81 -49.69, -52.76 APE12-dist-in 9.7291 APE11-dist-in 8.6653 APE10-dist-in 5.2788 APE9-dist-in 3.8051 None None None XRAY 2.0 0.183 0.216 A 293.0 274.0 0 26 26 0 [[38, 290]] 1.0 1yxt Homo sapiens CAMK_PIM1_HUMAN CAMK 3.2e-65 226.0 1.0 256.0 256.0 185 186 187 189 191 67 89 93 164 166 165 167.0 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 1XR1A P11309 32 308 313.0 ANP:501 ATPlike Active DFGin 5.8877 14.2143 BLAminus -138.05, 176.98 59.78, 85.31 -96.55, 16.88 287.93, 82.19 -61.38, -7.19 in-in in 8.717 Saltbr-in 2.833 HRD-naA -59.95, -51.82 71.23, 5.72 in-in-in SNCiii in-in ActLoopNT-in 2.7525 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.05, 45.66 APE9-dihe-na -114.17, -171.15 APE8-dihe-in -64.11, 112.97 APE8-rot-in 299.41 APE67-dihe-in -49.28, -12.21 -42.84, -67.53 APE12-dist-in 9.6083 APE11-dist-in 8.6947 APE10-dist-in 5.5225 APE9-dist-in 4.0703 None None None XRAY 2.1 0.267 0.301 A 300.0 277.0 0 26 26 0 [[38, 290]] 1.0 1xr1 Homo sapiens CAMK_PIM1_HUMAN CAMK 3.4e-65 225.8 1.0 256.0 256.0 185 186 187 189 191 67 89 93 164 166 165 167.0 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3A99A P11309 33 305 313.0 ANP:501 ATPlike Active DFGin 5.9337 14.254 BLAminus -128.38, 171.59 60.85, 87.29 -96.61, 22.08 288.57, 75.78 -65.84, -9.23 in-in in 8.7536 Saltbr-in 2.6044 HRD-naA -66.86, -47.45 66.12, 8.26 in-in-in SNCiii in-in ActLoopNT-in 2.8889 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.19, 26.41 APE9-dihe-na -87.51, -159.07 APE8-dihe-in -85.64, 119.66 APE8-rot-in 305.41 APE67-dihe-in -70.7, -5.81 -56.65, -39.81 APE12-dist-in 9.6122 APE11-dist-in 8.4607 APE10-dist-in 5.2903 APE9-dist-in 3.7779 None None None XRAY 1.6 0.187 0.206 A 320.0 273.0 0 26 26 0 [[38, 290]] 1.0 3a99 Homo sapiens CAMK_PIM1_HUMAN CAMK 4.3e-65 225.5 1.0 256.0 256.0 185 186 187 189 191 67 89 93 164 166 165 167.0 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 2BZKB P11309 33 305 313.0 ANP:1306 ATPlike Active DFGin 6.1262 14.4434 BLAminus -123.86, 174.78 64.57, 79.13 -87.5, 17.23 286.98, 86.61 -67.5, -17.62 in-in in 8.7809 Saltbr-in 2.7266 HRD-naA -70.49, -48.81 68.36, 6.4 in-in-in SNCiii in-in ActLoopNT-in 2.8129 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.63, 10.91 APE9-dihe-na -77.79, -156.22 APE8-dihe-in -90.85, 124.06 APE8-rot-in 315.85 APE67-dihe-in -68.94, -10.63 -60.69, -42.64 APE12-dist-in 9.4641 APE11-dist-in 8.4783 APE10-dist-in 4.8507 APE9-dist-in 3.7821 R250G None None XRAY 2.45 0.191 0.225 B 313.0 268.0 5 26 26 0 [[38, 290]] 1.0 2bzk Homo sapiens CAMK_PIM1_HUMAN CAMK 1.5e-64 223.7 1.0 256.0 256.0 185 186 187 189 191 67 89 93 164 166 165 167.0 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PLK1 PLK1_HUMAN 8X72A P53350 37 330 603.0 ANP:401 ATPlike Inactive DFGin 5.6741 14.5619 BLAminus -124.66, -175.79 56.01, 84.34 -93.5, 28.11 290.48, 83.55 -67.08, -22.62 out-in out 10.0362 Saltbr-in 3.3691 HRD-in -69.02, -52.36 73.21, 2.03 in-in-out SNCiio in-out ActLoopNT-in 2.9948 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -79.36, 95.87 APE9-dihe-na 140.51, 168.33 APE8-dihe-in -120.38, 96.0 APE8-rot-in 313.63 APE67-dihe-out -71.46, -55.88 -64.61, 149.56 APE12-dist-in 10.8497 APE11-dist-out 7.4546 APE10-dist-in 7.6527 APE9-dist-out 8.0434 None None None XRAY 2.2 0.198 0.25 A 333.0 294.0 0 28 28 0 [[53, 305]] 1.0 8x72 Homo sapiens CAMK_PLK1_HUMAN CAMK 1.7e-78 269.4 1.0 256.0 256.0 193 194 195 197 199 82 101 105 173 175 174 176.0 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
CAMK PLK1 PLK1_HUMAN 2OU7A P53350 37 328 603.0 ANP:500 ATPlike Inactive DFGin 5.511 14.6261 BLAminus -126.46, 177.9 64.03, 83.89 -94.43, 31.27 293.9, 81.92 -69.65, -29.63 out-in out 10.0179 Saltbr-in 3.5992 HRD-in -73.43, -50.53 79.22, -6.25 in-in-out SNCiio in-out ActLoopNT-in 2.9589 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -86.17, 94.2 APE9-dihe-na 146.34, 174.25 APE8-dihe-in -131.14, 97.57 APE8-rot-in 299.54 APE67-dihe-out -68.04, -58.6 -56.03, 146.92 APE12-dist-in 10.3811 APE11-dist-out 7.1861 APE10-dist-in 7.4365 APE9-dist-out 8.2407 T210V None None XRAY 2.4 0.205 0.235 A 335.0 292.0 0 28 28 0 [[53, 305]] 1.0 2ou7 Homo sapiens CAMK_PLK1_HUMAN CAMK 1.8e-78 269.4 1.0 256.0 256.0 193 194 195 197 199 82 101 105 173 175 174 176.0 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
CAMK PLK4 PLK4_HUMAN 3COKA O00444 2 266 970.0 ANP:60301 ATPlike Inactive DFGin 6.1437 15.3969 BLAminus -124.31, 169.68 62.14, 91.45 -100.82, 17.44 292.06, 88.73 -56.38, -36.52 in-out in 9.7683 Saltbr-out 4.5692 HRD-out -88.33, 122.35 -44.77, 114.93 out-in-none SNCoin in-none ActLoopNT-in 2.7877 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.25 0.211 0.261 A 278.0 232.0 33 28 9 19 [[12, 265]] 1.0 3cok Homo sapiens CAMK_PLK4_HUMAN CAMK 4.8e-82 281.0 1.0 256.0 256.0 153 154 155 157 159 41 60 64 133 135 134 136.0 193 181 176 175 174 173 172 171 170 90 Serine/threonine-protein kinase PLK4
CAMK PLK4 PLK4_HUMAN 3COKB O00444 2 266 970.0 ANP:60301 ATPlike Inactive DFGin 5.9149 15.3333 BLAminus -133.97, 164.53 62.63, 97.48 -104.66, 14.21 301.0, 88.72 -54.53, -38.93 in-out in 9.8039 Saltbr-out 7.1782 HRD-out -90.24, 129.56 -55.53, 110.17 out-in-none SNCoin in-none ActLoopNT-in 2.8338 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.25 0.211 0.261 B 278.0 232.0 33 28 9 19 [[12, 265]] 1.0 3cok Homo sapiens CAMK_PLK4_HUMAN CAMK 4.8e-82 281.0 1.0 256.0 256.0 153 154 155 157 159 41 60 64 133 135 134 136.0 193 181 176 175 174 173 172 171 170 90 Serine/threonine-protein kinase PLK4
CAMK RPS6KA5-2 KS6A5_HUMAN 3KN5A O75582 415 729 802.0 ANP:400 ATPlike None DFGin 5.4689 14.1425 BLAminus -120.9, 173.77 65.89, 86.51 -96.46, 22.04 287.59, 69.84 -51.57, -39.89 in-in in 8.8671 Saltbr-in 2.809 HRD-in -86.24, -52.51 73.21, 10.94 in-in-none SNCiin in-none ActLoopNT-in 2.9891 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.211 0.278 A 325.0 282.0 33 28 10 18 [[49, 318], [423, 687]] 2.0 3kn5 Homo sapiens CAMK_RPS6KA5-2_HUMAN CAMK 2.1e-87 298.7 5.0 256.0 252.0 564 565 566 568 570 455 468 472 541 543 542 544.0 604 592 587 586 585 584 583 582 581 499 Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA5-2 KS6A5_HUMAN 3KN5B O75582 415 729 802.0 ANP:400 ATPlike None DFGin 5.7693 14.2111 BLAminus -127.01, 177.83 61.12, 80.37 -96.03, 24.29 287.04, 69.05 -65.01, -20.75 in-in in 8.8724 Saltbr-in 2.7381 HRD-in -80.02, -49.37 72.67, 1.66 in-in-none SNCiin in-none ActLoopNT-in 2.867 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.211 0.278 B 325.0 289.0 26 28 10 18 [[49, 318], [423, 687]] 2.0 3kn5 Homo sapiens CAMK_RPS6KA5-2_HUMAN CAMK 2.1e-87 298.7 5.0 256.0 252.0 564 565 566 568 570 455 468 472 541 543 542 544.0 604 592 587 586 585 584 583 582 581 499 Ribosomal protein S6 kinase alpha-5
CAMK STK11 STK11_HUMAN 2WTKC Q15831 47 342 433.0 ANP:2 ATPlike Active DFGin 6.1917 13.745 BLAminus -119.65, -175.81 55.97, 66.27 -90.3, 25.87 311.18, 25.77 -80.53, -8.11 in-in in 9.443 Saltbr-in 3.361 HRD-in -68.47, -42.92 70.9, -7.9 in-in-in SNCiii in-in ActLoopNT-in 2.6483 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na 69.85, 15.07 APE9-dihe-na -72.04, -171.91 APE8-dihe-in -90.01, 115.78 APE8-rot-in 306.68 APE67-dihe-in -55.63, -13.05 -36.08, -60.58 APE12-dist-in 7.7844 APE11-dist-in 9.233 APE10-dist-in 5.3951 APE9-dist-in 3.1732 D194A None None XRAY 2.65 0.24 0.291 C 305.0 285.0 3 30 30 0 [[49, 309]] 1.0 2wtk Homo sapiens CAMK_STK11_HUMAN CAMK 7.7e-66 228.0 1.0 256.0 256.0 193 194 195 197 199 78 98 102 173 175 174 176.0 237 223 218 217 216 215 214 213 212 130 Serine/threonine-protein kinase STK11
CAMK STK11 STK11_HUMAN 2WTKF Q15831 45 340 433.0 ANP:4 ATPlike Active DFGin 5.9384 13.841 BLAminus -119.11, -173.26 54.53, 62.76 -80.33, 19.16 295.83, 69.09 -48.31, -46.43 in-in in 9.4829 Saltbr-in 3.5682 HRD-in -68.65, -42.45 72.6, -14.65 in-in-in SNCiii in-in ActLoopNT-in 2.9216 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na 45.91, 2.58 APE9-dihe-na -73.83, 178.68 APE8-dihe-in -66.98, 134.68 APE8-rot-in 293.57 APE67-dihe-in -65.1, -33.79 -54.08, -45.39 APE12-dist-in 8.609 APE11-dist-in 9.6587 APE10-dist-in 5.7934 APE9-dist-in 3.3127 D194A None None XRAY 2.65 0.24 0.291 F 305.0 268.0 16 30 30 0 [[49, 309]] 1.0 2wtk Homo sapiens CAMK_STK11_HUMAN CAMK 7.7e-66 228.0 1.0 256.0 256.0 193 194 195 197 199 78 98 102 173 175 174 176.0 237 223 218 217 216 215 214 213 212 130 Serine/threonine-protein kinase STK11
CK1 VRK1 VRK1_HUMAN 6AC9A Q99986 21 342 396.0 ANP:401 ATPlike Inactive DFGin 7.921 14.7058 BLAminus -114.21, 177.93 70.15, 93.84 -115.1, 19.79 299.42, 81.98 -60.26, -28.75 in-in in 7.9503 Saltbr-in 2.7794 HRD-in -85.24, -47.15 69.74, 5.52 in-in-out SNCiio in-out ActLoopNT-in 2.7991 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -132.17, 15.24 APE9-dihe-na 79.52, -153.87 APE8-dihe-in -97.68, 119.65 APE8-rot-in 299.88 APE67-dihe-in -62.87, -27.26 -44.77, -50.87 APE12-dist-in 9.478 APE11-dist-out 5.963 APE10-dist-out 10.7142 APE9-dist-in 3.8506 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.07 0.187 0.223 A 370.0 317.0 5 35 35 0 [[37, 326]] 1.0 6ac9 Homo sapiens CK1_VRK1_HUMAN CK1 8.9e-105 355.8 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 6AC9B Q99986 21 341 396.0 ANP:401 ATPlike Inactive DFGin 7.9163 14.7395 BLAminus -115.54, 178.38 75.12, 91.43 -115.59, 17.29 297.69, 88.6 -57.57, -34.6 in-in in 8.0934 Saltbr-in 2.7697 HRD-in -83.61, -50.49 74.28, -0.88 in-in-out SNCiio in-out ActLoopNT-in 2.7931 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -114.62, 8.0 APE9-dihe-na 78.71, -152.8 APE8-dihe-in -103.98, 122.42 APE8-rot-in 297.61 APE67-dihe-in -64.96, -28.03 -44.02, -51.48 APE12-dist-in 9.9903 APE11-dist-out 5.4332 APE10-dist-out 10.7488 APE9-dist-in 3.7267 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.07 0.187 0.223 B 370.0 316.0 5 35 35 0 [[37, 326]] 1.0 6ac9 Homo sapiens CK1_VRK1_HUMAN CK1 8.9e-105 355.8 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 6AC9C Q99986 24 341 396.0 ANP:402 ATPlike Inactive DFGin 7.9271 14.3251 BLAminus -121.92, 176.09 69.3, 88.62 -104.37, 22.99 293.32, 87.67 -64.92, -32.52 in-in in 7.6046 Saltbr-in 2.7935 HRD-in -88.58, -46.78 72.09, 4.58 in-in-out SNCiio in-out ActLoopNT-in 2.8557 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -67.72, 154.65 APE9-dihe-na 94.16, -162.22 APE8-dihe-in -91.17, 117.25 APE8-rot-in 299.96 APE67-dihe-in -65.18, -24.09 -48.81, -46.56 APE12-dist-out 14.9656 APE11-dist-in 13.64 APE10-dist-in 7.9253 APE9-dist-in 4.1526 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.07 0.187 0.223 C 370.0 307.0 11 35 35 0 [[37, 326]] 1.0 6ac9 Homo sapiens CK1_VRK1_HUMAN CK1 8.9e-105 355.8 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 6AC9D Q99986 23 341 396.0 ANP:402 ATPlike Inactive DFGin 7.7388 14.3302 BLAminus -116.24, 179.23 65.24, 86.32 -103.3, 26.16 293.03, 86.03 -64.75, -25.98 in-in in 7.7219 Saltbr-in 2.7969 HRD-in -87.33, -42.3 69.45, 1.55 in-in-out SNCiio in-out ActLoopNT-in 2.9922 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -66.0, 154.0 APE9-dihe-na 92.71, -167.74 APE8-dihe-in -86.89, 111.15 APE8-rot-in 299.25 APE67-dihe-in -66.58, -28.49 -43.2, -46.61 APE12-dist-out 14.8296 APE11-dist-in 13.4467 APE10-dist-in 7.7373 APE9-dist-in 4.2604 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.07 0.187 0.223 D 370.0 306.0 13 35 35 0 [[37, 326]] 1.0 6ac9 Homo sapiens CK1_VRK1_HUMAN CK1 8.9e-105 355.8 1.0 261.0 261.0 196 197 198 200 202 71 83 87 174 176 175 177.0 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CMGC CDK1 CDK1_HUMAN 9SKQA P06493 3 288 297.0 ANP:60301 ATPlike Inactive DFGin 7.1434 16.0323 BLAminus -125.06, -177.1 57.55, 62.82 -86.84, 50.52 271.32, 82.93 -98.1, -26.9 in-out in 9.7163 Saltbr-out 5.762 HRD-in -83.48, -58.42 64.77, 13.47 out-in-out SNCoio in-out ActLoopNT-in 2.6846 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iiii APE10-dihe-na -142.74, 165.15 APE9-dihe-na 69.23, -36.98 APE8-dihe-out 60.52, 63.14 APE8-rot-out 73.99 APE67-dihe-out 57.27, -80.66 61.32, -166.6 APE12-dist-in 12.7031 APE11-dist-in 10.0266 APE10-dist-in 7.0709 APE9-dist-in 3.7308 None TPO161 TPO161 EM 3.4 999.0 999.0 A 302.0 286.0 0 28 28 0 [[4, 287]] 1.0 9skq Homo sapiens CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1.0 301.0 301.0 145 146 147 149 151 33 51 55 125 127 126 128.0 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
CMGC CDK12 CDK12_HUMAN 4CXAA Q9NYV4 718 1050 1490.0 ANP:2051 ATPlike Inactive DFGin 6.4362 15.0223 BLAminus -127.47, 178.63 59.83, 84.78 -103.34, 39.58 291.64, 72.71 -78.99, -14.54 in-in in 8.1775 Saltbr-in 2.5134 HRD-in -89.68, -50.66 63.81, 17.68 in-in-out SNCiio in-out ActLoopNT-in 2.7933 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -113.43, 159.2 APE9-dihe-na 63.92, 139.76 APE8-dihe-in -56.37, 145.01 APE8-rot-out 63.76 APE67-dihe-in -64.68, -22.99 -55.23, -40.79 APE12-dist-in 13.2123 APE11-dist-in 11.6623 APE10-dist-in 7.3626 APE9-dist-in 3.5055 None TPO893 TPO893 XRAY 3.15 0.224 0.279 A 340.0 330.0 3 29 28 1 [[727, 1020]] 1.0 4cxa Homo sapiens CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK2 CDK2_HUMAN 9QCVK P24941 1 292 298.0 ANP:60301 ATPlike Inactive DFGin 6.4954 15.8072 BLAminus -144.96, -178.89 57.85, 64.57 -85.72, 49.93 282.03, 73.0 -84.65, -33.03 in-out in 9.3 Saltbr-out 4.6184 HRD-in -70.41, -54.19 69.05, 2.44 out-in-out SNCoio in-out ActLoopNT-in 2.5765 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -164.79, 153.04 APE9-dihe-na -68.87, 164.19 APE8-dihe-in -61.62, 153.89 APE8-rot-out 41.16 APE67-dihe-in -67.77, -23.98 -60.52, -33.7 APE12-dist-in 11.1549 APE11-dist-out 6.1121 APE10-dist-out 8.8972 APE9-dist-in 4.078 None None None EM 2.5 999.0 999.0 K 301.0 292.0 0 28 28 0 [[4, 286]] 1.0 9qcv Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK7 CDK7_HUMAN 8R99A P50613 10 311 346.0 ANP:401 ATPlike Inactive DFGin 6.9207 15.0738 BLAminus -136.18, 178.53 62.42, 80.05 -92.8, 32.41 285.07, 70.02 -64.17, -34.45 in-out in 9.4572 Saltbr-out 5.6061 HRD-in -70.53, -54.5 69.94, 6.7 out-in-out SNCoio in-out ActLoopNT-in 2.7107 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -115.64, 148.75 APE9-dihe-na -60.57, 161.29 APE8-dihe-in -48.68, 142.11 APE8-rot-out 161.53 APE67-dihe-in -67.83, -20.09 -55.43, -38.94 APE12-dist-in 10.4492 APE11-dist-out 5.162 APE10-dist-out 9.4484 APE9-dist-in 3.7154 W132R,S164D,T170E None None XRAY 1.81 0.178 0.22 A 371.0 283.0 19 28 28 0 [[12, 295]] 1.0 8r99 Homo sapiens CMGC_CDK7_HUMAN CMGC 7.3e-78 269.6 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 9QCVJ P50613 10 346 346.0 ANP:60401 ATPlike Inactive DFGin 6.8121 15.5797 BLAminus -138.8, -173.47 57.69, 63.92 -85.78, 14.86 277.56, 80.3 -62.91, -29.56 in-out in 8.3041 Saltbr-out 4.7072 HRD-in -68.14, -50.51 67.46, 2.9 out-in-out SNCoio in-out ActLoopNT-in 2.8164 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -128.9, 162.73 APE9-dihe-na -74.02, 167.46 APE8-dihe-in -56.29, 150.3 APE8-rot-out 36.33 APE67-dihe-in -61.72, -30.52 -65.73, -24.93 APE12-dist-in 11.2442 APE11-dist-out 5.3402 APE10-dist-out 8.9959 APE9-dist-in 3.8077 None None None EM 2.5 999.0 999.0 J 391.0 307.0 0 28 28 0 [[12, 295]] 1.0 9qcv Homo sapiens CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 9SKQJ P50613 9 346 346.0 ANP:60401 ATPlike Inactive DFGin 7.0888 16.0793 BLAminus -134.4, -172.6 54.33, 63.76 -84.59, 21.04 273.82, 84.09 -68.06, -13.54 in-out in 8.6851 Saltbr-out 3.6038 HRD-in -66.63, -50.41 66.76, -1.97 out-in-out SNCoio in-out ActLoopNT-in 3.0208 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -107.15, 155.19 APE9-dihe-na -64.85, 155.06 APE8-dihe-in -50.04, 149.57 APE8-rot-out 168.49 APE67-dihe-in -67.74, -34.69 -63.59, -17.75 APE12-dist-in 10.5875 APE11-dist-out 5.6701 APE10-dist-out 9.403 APE9-dist-in 3.9875 None None None EM 3.4 999.0 999.0 J 391.0 306.0 0 28 28 0 [[12, 295]] 1.0 9skq Homo sapiens CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BA P50613 1 311 346.0 ANP:401 ATPlike Inactive DFGin 6.6665 15.0398 None -136.41, -179.13 75.36, -66.57 59.32, 16.33 291.11, 69.78 55.95, 32.69 out-out out 13.486 Saltbr-out 13.7543 HRD-in -65.3, -54.78 73.94, 0.68 out-out-out SNCooo out-out ActLoopNT-out 12.5504 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -74.63, 115.42 APE9-dihe-na -115.54, -2.31 APE8-dihe-out -56.05, -31.84 APE8-rot-out 157.42 APE67-dihe-in -63.34, -23.16 -66.49, -24.29 APE12-dist-out 18.0017 APE11-dist-out 20.1866 APE10-dist-out 16.0858 APE9-dist-out 11.4652 S164D,T170E None None XRAY 2.21 0.195 0.243 A 352.0 301.0 10 28 28 0 [[12, 295]] 1.0 8r9b Homo sapiens CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BB P50613 3 310 346.0 ANP:402 ATPlike Inactive DFGin 6.5631 15.0836 None -126.22, 177.01 84.52, -73.28 65.77, 22.93 292.14, 76.04 47.33, 39.02 out-out out 13.6069 Saltbr-out 11.882 HRD-in -71.08, -53.54 74.78, -6.63 out-out-out SNCooo out-out ActLoopNT-out 12.9359 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -81.04, 115.32 APE9-dihe-na -115.04, 1.93 APE8-dihe-out -60.49, -32.76 APE8-rot-out 168.86 APE67-dihe-in -59.67, -24.77 -68.61, -28.01 APE12-dist-out 17.7792 APE11-dist-out 20.1865 APE10-dist-out 16.1566 APE9-dist-out 11.4157 S164D,T170E None None XRAY 2.21 0.195 0.243 B 352.0 298.0 10 28 28 0 [[12, 295]] 1.0 8r9b Homo sapiens CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BC P50613 8 311 346.0 ANP:402 ATPlike Inactive DFGin 6.4512 15.3403 None -116.21, 176.78 77.39, -97.04 64.16, 26.01 311.61, 20.83 46.47, 58.36 out-out out 13.1044 Saltbr-out 12.1328 HRD-in -78.41, -55.45 77.67, -2.52 out-out-out SNCooo out-out ActLoopNT-out 12.9218 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 132.76 APE9-dihe-na -87.2, -35.35 APE8-dihe-out -49.87, -35.32 APE8-rot-in 271.7 APE67-dihe-in -63.34, -21.13 -58.67, -34.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.9279 APE9-dist-out 10.9338 S164D,T170E None None XRAY 2.21 0.195 0.243 C 352.0 276.0 28 28 16 12 [[12, 295]] 1.0 8r9b Homo sapiens CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BD P50613 9 311 346.0 ANP:402 ATPlike Inactive DFGin 5.1856 15.5294 None -119.23, -173.72 58.44, -119.7 56.58, 114.74 106.06, 59.9 70.5, -151.21 out-out out 13.0617 Saltbr-out 12.3535 HRD-in -80.52, -56.05 80.67, -8.56 out-out-out SNCooo out-out ActLoopNT-out 13.0554 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -29.49 APE9-dihe-na -113.47, -32.42 APE8-dihe-out -62.11, -27.52 APE8-rot-out 75.68 APE67-dihe-in -62.12, -24.79 -50.05, -35.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.1604 APE9-dist-out 11.1556 S164D,T170E None None XRAY 2.21 0.195 0.243 D 352.0 277.0 26 28 18 10 [[12, 295]] 1.0 8r9b Homo sapiens CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK9 CDK9_HUMAN 3MIAA P50750 8 340 372.0 ANP:352 ATPlike Active DFGin 6.803 15.0773 BLAminus -137.71, 176.33 64.58, 74.97 -96.55, 26.44 284.7, 90.38 -67.18, -14.54 in-in in 9.3135 Saltbr-in 2.6891 HRD-in -70.81, -51.43 63.16, 28.9 in-in-in SNCiii in-in ActLoopNT-in 2.9572 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.04, 160.49 APE9-dihe-na 82.03, 127.94 APE8-dihe-in -49.75, 143.51 APE8-rot-in 280.63 APE67-dihe-in -52.26, -14.47 -51.96, -57.94 APE12-dist-in 13.2577 APE11-dist-in 11.5238 APE10-dist-in 6.949 APE9-dist-in 3.5228 None TPO186 TPO186 XRAY 3.0 0.219 0.287 A 351.0 325.0 8 32 32 0 [[19, 315]] 1.0 3mia Homo sapiens CMGC_CDK9_HUMAN CMGC 5.1e-80 274.8 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CMGC CSNK2A1 CSK21_HUMAN 3JUHA P68400 2 335 391.0 ANP:339 ATPlike Active DFGin 7.4007 16.2423 BLAminus -115.69, -178.29 60.62, 71.57 -93.06, 11.37 295.1, 82.09 -62.22, -22.13 in-in in 9.7211 Saltbr-in 2.7457 HRD-in -70.06, -49.94 64.15, 21.46 in-in-in SNCiii in-in ActLoopNT-in 2.8624 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.98, 153.86 APE9-dihe-na 70.33, -177.46 APE8-dihe-in -104.19, 142.14 APE8-rot-in 291.28 APE67-dihe-in -67.33, -12.83 -40.87, -55.27 APE12-dist-in 12.3163 APE11-dist-in 9.5782 APE10-dist-in 6.0441 APE9-dist-in 3.0857 V66A,M163L None None XRAY 1.66 0.158 0.218 A 335.0 334.0 0 27 27 0 [[39, 324]] 1.0 3juh Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.1e-70 244.1 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 3JUHB P68400 2 335 391.0 ANP:339 ATPlike Active DFGin 7.4915 16.3556 BLAminus -124.69, -176.29 51.46, 71.26 -80.35, 23.48 299.01, 83.37 -80.68, -22.43 in-in in 9.8518 Saltbr-in 2.6994 HRD-in -76.38, -50.5 78.84, -1.13 in-in-in SNCiii in-in ActLoopNT-in 2.8067 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.59, 175.23 APE9-dihe-na 56.07, 138.8 APE8-dihe-in -58.03, 149.04 APE8-rot-in 282.66 APE67-dihe-in -69.98, -19.52 -43.94, -46.02 APE12-dist-in 12.7139 APE11-dist-in 9.5413 APE10-dist-in 5.8839 APE9-dist-in 3.4107 V66A,M163L None None XRAY 1.66 0.158 0.218 B 335.0 334.0 0 27 27 0 [[39, 324]] 1.0 3juh Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.1e-70 244.1 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 3NSZA P68400 2 328 391.0 ANP:1000 ATPlike Active DFGin 7.2905 16.6392 BLAminus -116.89, -174.28 57.53, 72.95 -91.24, 19.04 295.43, 81.74 -67.97, -19.44 in-in in 9.5596 Saltbr-in 2.7206 HRD-in -71.38, -46.87 68.1, 12.99 in-in-in SNCiii in-in ActLoopNT-in 2.8692 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.59, 174.99 APE9-dihe-na 61.7, -173.37 APE8-dihe-in -118.84, 140.8 APE8-rot-in 296.4 APE67-dihe-in -69.07, -13.11 -30.5, -60.15 APE12-dist-in 12.6047 APE11-dist-in 10.3158 APE10-dist-in 6.145 APE9-dist-in 2.961 None None None XRAY 1.3 0.169 0.187 A 330.0 327.0 0 27 27 0 [[39, 324]] 1.0 3nsz Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.3e-69 240.7 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 1PJKA P68400 2 332 391.0 ANP:340 ATPlike Active DFGin 7.4402 16.2383 BLAminus -115.92, -179.78 53.21, 80.99 -96.44, 28.53 295.64, 78.1 -72.28, -30.66 in-in in 8.9302 Saltbr-in 2.8101 HRD-in -80.54, -40.11 57.34, 9.1 in-in-in SNCiii in-in ActLoopNT-in 3.0195 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.58, 173.24 APE9-dihe-na 63.2, 174.94 APE8-dihe-in -93.15, 157.9 APE8-rot-in 277.8 APE67-dihe-in -66.77, -23.27 -54.74, -47.48 APE12-dist-in 13.0256 APE11-dist-in 10.6695 APE10-dist-in 6.3684 APE9-dist-in 3.1734 None None None XRAY 2.5 0.188 0.257 A 334.0 331.0 0 27 27 0 [[39, 324]] 1.0 1pjk Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.3e-69 240.6 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 2PVRA P68400 2 329 391.0 ANP:6004 ATPlike Active DFGin 7.4922 16.4969 BLAminus -121.67, -179.6 56.35, 70.32 -89.0, 17.49 296.64, 81.69 -72.81, -15.87 in-in in 9.2839 Saltbr-in 2.7005 HRD-in -75.03, -46.77 70.22, 6.37 in-in-in SNCiii in-in ActLoopNT-in 2.8603 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.8, 175.01 APE9-dihe-na 60.61, 163.14 APE8-dihe-in -93.89, 147.69 APE8-rot-in 305.18 APE67-dihe-in -67.68, -15.16 -34.32, -58.13 APE12-dist-in 12.7281 APE11-dist-in 10.3458 APE10-dist-in 6.1308 APE9-dist-in 3.1892 None None None XRAY 1.605 0.187 0.241 A 334.0 328.0 0 27 27 0 [[39, 324]] 1.0 2pvr Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.3e-69 240.6 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 3WOWA P68400 2 335 391.0 ANP:403 ATPlike Inactive DFGin 7.3618 16.2106 BLAminus -119.7, -164.32 31.16, 87.67 -91.29, 15.78 292.48, 84.38 -76.59, -15.17 in-in in 9.0133 Saltbr-in 2.8966 HRD-in -75.03, -42.77 66.59, 8.6 in-in-out SNCiio in-out ActLoopNT-in 2.827 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -147.66, 173.4 APE9-dihe-na 59.33, 149.57 APE8-dihe-in -60.19, 149.81 APE8-rot-out 155.74 APE67-dihe-in -68.18, -10.89 -45.04, -52.54 APE12-dist-in 12.4625 APE11-dist-in 9.8934 APE10-dist-in 6.0041 APE9-dist-in 3.2376 None None None XRAY 2.5 0.187 0.24 A 340.0 334.0 0 27 27 0 [[39, 324]] 1.0 3wow Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.4e-69 240.5 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 1JWHA P68400 2 337 391.0 ANP:340 ATPlike Inactive DFGin 7.2516 16.2349 BLAminus -136.81, -165.56 40.66, 74.27 -89.27, 13.16 294.34, 91.77 -66.65, -32.67 in-in in 9.5638 Saltbr-in 2.5057 HRD-in -80.54, -35.51 50.69, 18.56 in-in-out SNCiio in-out ActLoopNT-in 2.9318 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -124.17, 169.91 APE9-dihe-na 68.04, 157.3 APE8-dihe-in -72.41, 153.53 APE8-rot-out 204.94 APE67-dihe-in -51.97, -16.72 -49.32, -64.87 APE12-dist-in 12.7307 APE11-dist-in 10.8563 APE10-dist-in 6.2863 APE9-dist-in 3.369 None None None XRAY 3.1 0.267 0.338 A 337.0 336.0 0 27 27 0 [[39, 324]] 1.0 1jwh Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.4e-69 240.6 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 3U87A P68400 2 331 391.0 ANP:60401 ATPlike Inactive DFGin 7.5451 16.2307 BLAminus -123.37, -169.57 51.0, 85.39 -106.65, 25.22 299.48, 83.64 -72.72, -19.34 in-in in 9.2674 Saltbr-in 2.765 HRD-in -71.91, -49.46 70.99, 8.66 in-in-out SNCiio in-out ActLoopNT-in 2.8507 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.96, 169.28 APE9-dihe-na 66.95, 166.44 APE8-dihe-in -75.94, 153.25 APE8-rot-out 174.74 APE67-dihe-in -70.96, -11.07 -53.15, -46.69 APE12-dist-in 12.8429 APE11-dist-in 11.0354 APE10-dist-in 6.142 APE9-dist-in 3.5391 None None None XRAY 2.9 0.187 0.218 A 349.0 324.0 0 27 27 0 [[39, 324]] 1.0 3u87 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.5e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 3U87B P68400 2 331 391.0 ANP:60401 ATPlike Active DFGin 7.4708 16.335 BLAminus -123.33, -169.35 50.94, 85.5 -106.65, 24.88 299.58, 83.47 -72.97, -19.72 in-in in 9.5055 Saltbr-in 2.8482 HRD-in -72.0, -49.6 70.96, 8.41 in-in-in SNCiii in-in ActLoopNT-in 2.7801 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.34, 168.89 APE9-dihe-na 66.61, 166.24 APE8-dihe-in -76.34, 153.62 APE8-rot-in 296.27 APE67-dihe-in -70.99, -10.83 -52.99, -46.79 APE12-dist-in 12.8215 APE11-dist-in 10.8013 APE10-dist-in 6.1498 APE9-dist-in 3.5766 None None None XRAY 2.9 0.187 0.218 B 349.0 324.0 0 27 27 0 [[39, 324]] 1.0 3u87 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.5e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A2 CSK22_HUMAN 8QCGA P19784 7 330 350.0 ANP:401 ATPlike Inactive DFGin 7.2922 16.4059 BLAminus -116.12, -179.5 60.93, 75.12 -92.44, 17.38 295.14, 82.0 -69.37, -19.53 in-out in 9.9974 Saltbr-out 4.5956 HRD-in -74.12, -49.68 72.07, 8.96 out-in-in SNCoii in-in ActLoopNT-in 2.8896 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.46, 172.69 APE9-dihe-na 61.42, 170.02 APE8-dihe-in -97.67, 147.66 APE8-rot-in 300.74 APE67-dihe-in -69.16, -14.55 -36.76, -56.59 APE12-dist-in 12.627 APE11-dist-in 10.1807 APE10-dist-in 6.1313 APE9-dist-in 3.1203 C336S None None XRAY 1.04 0.151 0.17 A 364.0 324.0 0 27 27 0 [[40, 325]] 1.0 8qcg Homo sapiens CMGC_CSNK2A2_HUMAN CMGC 1e-69 241.0 1.0 301.0 301.0 175 176 177 179 181 69 82 86 154 156 155 157.0 215 202 197 196 195 194 193 192 191 115 Casein kinase II subunit alpha'
CMGC CSNK2A2 CSK22_HUMAN 8QCGB P19784 7 333 350.0 ANP:401 ATPlike Active DFGin 7.3143 16.2087 BLAminus -113.91, -178.96 61.11, 75.42 -92.86, 17.98 298.38, 79.8 -69.62, -20.0 in-in in 9.4361 Saltbr-in 2.8304 HRD-in -72.51, -49.6 69.57, 9.93 in-in-in SNCiii in-in ActLoopNT-in 2.8276 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.91, 170.94 APE9-dihe-na 61.2, 166.37 APE8-dihe-in -93.43, 149.98 APE8-rot-in 300.62 APE67-dihe-in -69.2, -15.18 -40.28, -54.89 APE12-dist-in 12.6573 APE11-dist-in 10.2948 APE10-dist-in 6.1719 APE9-dist-in 3.1097 C336S None None XRAY 1.04 0.151 0.17 B 364.0 327.0 0 27 27 0 [[40, 325]] 1.0 8qcg Homo sapiens CMGC_CSNK2A2_HUMAN CMGC 1e-69 241.0 1.0 301.0 301.0 175 176 177 179 181 69 82 86 154 156 155 157.0 215 202 197 196 195 194 193 192 191 115 Casein kinase II subunit alpha'
CMGC DYRK1A DYR1A_HUMAN 7A4OA Q13627 136 481 763.0 ANP:501 ATPlike Active DFGin 7.4043 15.0335 BLAminus -121.6, 173.77 67.88, 73.96 -92.34, 22.26 284.87, 82.1 -70.26, -21.97 in-in in 8.6845 Saltbr-in 2.7935 HRD-in -65.03, -49.19 79.83, -0.94 in-in-in SNCiii in-in ActLoopNT-in 2.7995 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.61, 174.39 APE9-dihe-na 70.74, 151.67 APE8-dihe-in -72.34, 134.57 APE8-rot-in 295.77 APE67-dihe-in -65.19, -24.46 -43.45, -47.13 APE12-dist-in 10.0985 APE11-dist-in 12.2369 APE10-dist-in 7.723 APE9-dist-in 3.1562 None PTR321 PTR321 XRAY 1.9 0.18 0.203 A 382.0 341.0 5 25 25 0 [[159, 479]] 1.0 7a4o Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7A4OB Q13627 134 481 763.0 ANP:501 ATPlike Inactive DFGin 7.2232 15.0468 BLAminus -127.4, 170.29 72.8, 80.08 -93.18, 24.5 286.73, 76.67 -71.46, -26.03 in-in in 8.3652 Saltbr-in 2.7974 HRD-in -57.9, -49.71 71.19, 2.83 in-in-out SNCiio in-out ActLoopNT-in 2.8396 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -84.65, 164.16 APE9-dihe-na 75.07, 150.77 APE8-dihe-in -68.35, 138.34 APE8-rot-in 298.16 APE67-dihe-in -63.89, -24.74 -46.52, -48.39 APE12-dist-out 14.0969 APE11-dist-in 11.8963 APE10-dist-in 7.5367 APE9-dist-in 3.0281 None PTR321 PTR321 XRAY 1.9 0.18 0.203 B 382.0 341.0 7 25 25 0 [[159, 479]] 1.0 7a4o Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC GSK3B GSK3B_HUMAN 1J1BA P49841 35 388 420.0 ANP:60430 ATPlike Active DFGin 6.7667 13.7876 BLAminus -136.8, -178.88 61.6, 83.12 -97.64, 25.1 286.09, 80.4 -68.7, -13.11 in-in in 8.5659 Saltbr-in 2.59 HRD-in -71.16, -45.98 70.36, 3.88 in-in-in SNCiii in-in ActLoopNT-in 3.0085 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -88.52, 175.26 APE9-dihe-na 75.44, 133.64 APE8-dihe-in -75.76, 147.49 APE8-rot-in 306.57 APE67-dihe-inflip 98.15, -33.72 -56.43, 141.52 APE12-dist-in 13.0562 APE11-dist-in 10.9736 APE10-dist-in 5.8926 APE9-dist-in 3.1122 None None None XRAY 1.8 0.216 0.242 A 420.0 354.0 0 27 27 0 [[56, 340]] 1.0 1j1b Homo sapiens CMGC_GSK3B_HUMAN CMGC 3.2e-70 242.8 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 1J1BB P49841 23 386 420.0 ANP:60930 ATPlike Active DFGin 6.6091 13.6686 BLAminus -136.4, -177.03 61.49, 81.88 -98.08, 27.2 288.49, 82.07 -71.33, -13.14 in-in in 8.4573 Saltbr-in 2.713 HRD-in -67.51, -45.87 68.87, 6.43 in-in-in SNCiii in-in ActLoopNT-in 2.9624 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -90.88, 174.17 APE9-dihe-na 76.18, 138.08 APE8-dihe-in -76.12, 141.41 APE8-rot-in 301.11 APE67-dihe-inflip 98.0, -37.59 -54.78, 144.25 APE12-dist-in 12.9784 APE11-dist-in 11.0659 APE10-dist-in 6.0113 APE9-dist-in 3.1744 None None None XRAY 1.8 0.216 0.242 B 420.0 364.0 0 27 27 0 [[56, 340]] 1.0 1j1b Homo sapiens CMGC_GSK3B_HUMAN CMGC 3.2e-70 242.8 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 8XN6A P49841 35 384 420.0 ANP:501 ATPlike Active DFGin 6.682 13.8624 BLAminus -137.72, 173.39 67.73, 84.48 -99.84, 22.57 287.77, 80.54 -65.33, -24.58 in-in in 8.4632 Saltbr-in 2.6302 HRD-in -71.05, -47.88 67.82, 15.5 in-in-in SNCiii in-in ActLoopNT-in 3.0543 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.0, 164.43 APE9-dihe-na 85.44, 135.36 APE8-dihe-in -74.2, 151.55 APE8-rot-in 291.81 APE67-dihe-in -69.28, -17.83 -36.59, -67.98 APE12-dist-in 12.9066 APE11-dist-in 10.7867 APE10-dist-in 5.6801 APE9-dist-in 3.1824 None None None XRAY 2.4 0.194 0.242 A 421.0 350.0 0 27 27 0 [[56, 340]] 1.0 8xn6 Homo sapiens CMGC_GSK3B_HUMAN CMGC 3.3e-70 242.8 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 8XN6B P49841 26 386 420.0 ANP:501 ATPlike Inactive DFGin 6.5384 13.6503 BLAminus -128.79, 173.26 73.68, 79.74 -95.9, 22.51 291.63, 80.46 -68.54, -21.83 in-in in 8.3292 Saltbr-in 2.8234 HRD-in -66.59, -53.03 79.09, 5.6 in-in-out SNCiio in-out ActLoopNT-in 2.9512 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -88.32, 165.9 APE9-dihe-na 83.63, 132.42 APE8-dihe-in -59.67, 147.17 APE8-rot-out 189.94 APE67-dihe-in -64.51, -21.68 -60.38, -49.59 APE12-dist-in 13.0235 APE11-dist-in 10.9696 APE10-dist-in 5.846 APE9-dist-in 3.0807 None None None XRAY 2.4 0.194 0.242 B 421.0 359.0 2 27 27 0 [[56, 340]] 1.0 8xn6 Homo sapiens CMGC_GSK3B_HUMAN CMGC 3.3e-70 242.8 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 1PYXA P49841 35 386 420.0 ANP:1001 ATPlike Active DFGin 6.5838 13.6216 BLAminus -138.81, -178.07 65.18, 79.92 -98.83, 26.07 289.95, 78.27 -73.24, -7.6 in-in in 8.3727 Saltbr-in 2.7648 HRD-in -67.79, -47.84 71.28, 6.53 in-in-in SNCiii in-in ActLoopNT-in 2.9483 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -86.12, 170.17 APE9-dihe-na 80.64, 129.74 APE8-dihe-in -63.79, 140.05 APE8-rot-in 299.48 APE67-dihe-in -56.43, -21.61 -20.65, -80.28 APE12-dist-in 12.9032 APE11-dist-in 10.9366 APE10-dist-in 5.7841 APE9-dist-in 3.1495 None None None XRAY 2.4 0.206 0.233 A 422.0 343.0 9 27 27 0 [[56, 340]] 1.0 1pyx Homo sapiens CMGC_GSK3B_HUMAN CMGC 3.3e-70 242.8 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 1PYXB P49841 35 383 420.0 ANP:2001 ATPlike Active DFGin 6.5927 13.7178 BLAminus -140.94, -178.47 65.26, 79.98 -98.11, 22.32 290.75, 76.51 -68.32, -7.73 in-in in 8.4877 Saltbr-in 2.6657 HRD-in -69.98, -47.18 70.83, 5.6 in-in-in SNCiii in-in ActLoopNT-in 2.9383 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -89.3, 169.41 APE9-dihe-na 81.27, 131.24 APE8-dihe-in -66.67, 140.79 APE8-rot-in 300.74 APE67-dihe-in -56.9, -22.2 -20.58, -79.9 APE12-dist-in 12.8382 APE11-dist-in 10.8615 APE10-dist-in 5.7183 APE9-dist-in 3.132 None None None XRAY 2.4 0.206 0.233 B 422.0 338.0 11 27 27 0 [[56, 340]] 1.0 1pyx Homo sapiens CMGC_GSK3B_HUMAN CMGC 3.3e-70 242.8 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC MAPK1 MK01_HUMAN 4H3QA P28482 9 360 360.0 ANP:401 ATPlike Inactive DFGin 6.6034 15.6819 BLAminus -131.43, 178.9 70.32, 68.42 -96.0, 22.91 290.2, 68.59 -63.35, -20.75 in-in in 9.2328 Saltbr-in 2.8208 HRD-in -71.26, -48.66 68.7, 4.98 in-in-out SNCiio in-out ActLoopNT-in 2.9419 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioo APE10-dihe-na -133.14, 155.68 APE9-dihe-na -60.56, -35.88 APE8-dihe-out -124.57, -73.58 APE8-rot-out 150.68 APE67-dihe-out -67.06, -6.51 92.51, -9.23 APE12-dist-in 9.1353 APE11-dist-in 11.6615 APE10-dist-out 8.7525 APE9-dist-out 10.9003 R77A,C161S,I255G,E314A None None XRAY 2.2 0.184 0.232 A 362.0 352.0 0 31 31 0 [[25, 313]] 1.0 4h3q Homo sapiens CMGC_MAPK1_HUMAN CMGC 3.4e-85 291.8 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6OPGA P28482 10 358 360.0 ANP:60401 ATPlike Active DFGin 6.5353 14.6675 BLAminus -130.49, -173.97 55.35, 72.85 -87.66, 25.26 285.94, 65.79 -65.31, -19.22 in-in in 9.0658 Saltbr-in 2.6952 HRD-in -72.87, -54.34 77.9, 3.87 in-in-in SNCiii in-in ActLoopNT-in 2.7583 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -102.35, 163.88 APE9-dihe-na 79.13, 168.47 APE8-dihe-in -88.92, 138.85 APE8-rot-in 292.11 APE67-dihe-in -68.23, -14.82 -51.35, -45.86 APE12-dist-in 12.5703 APE11-dist-in 11.1338 APE10-dist-in 6.6534 APE9-dist-in 2.9424 None TPO185,PTR187 TPO185,PTR187 XRAY 2.9 0.16 0.239 A 354.0 349.0 0 31 31 0 [[25, 313]] 1.0 6opg Homo sapiens CMGC_MAPK1_HUMAN CMGC 8.6e-86 293.8 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 2Y9QA P28482 9 358 360.0 ANP:1359 ATPlike Inactive DFGin 6.7756 15.4463 BLAminus -131.56, -173.58 71.27, 62.6 -94.15, 18.41 284.56, 67.7 -60.61, -22.82 in-in in 9.1065 Saltbr-in 2.7907 HRD-in -69.38, -48.16 75.91, -5.63 in-in-out SNCiio in-out ActLoopNT-in 2.7879 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -136.29, 162.19 APE9-dihe-na -69.67, -30.11 APE8-dihe-in -153.45, 140.36 APE8-rot-out 183.83 APE67-dihe-in -69.16, -12.41 -110.3, 4.7 APE12-dist-in 9.6632 APE11-dist-in 12.83 APE10-dist-out 9.194 APE9-dist-out 11.5088 None None None XRAY 1.55 0.156 0.177 A 362.0 350.0 0 31 31 0 [[25, 313]] 1.0 2y9q Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.3e-86 293.7 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4FMQA P28482 9 358 360.0 ANP:401 ATPlike Inactive DFGin 6.797 15.309 BLAminus -133.64, -170.94 67.61, 66.1 -98.24, 21.64 282.65, 68.61 -61.3, -22.42 in-in in 9.1314 Saltbr-in 2.9364 HRD-in -73.07, -47.52 74.25, -10.43 in-in-out SNCiio in-out ActLoopNT-in 2.8302 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -138.4, 159.9 APE9-dihe-na -70.94, -24.68 APE8-dihe-in -158.11, 141.22 APE8-rot-out 179.47 APE67-dihe-in -66.85, -11.48 -113.88, 6.26 APE12-dist-in 9.4738 APE11-dist-in 12.7001 APE10-dist-out 9.2253 APE9-dist-out 11.64 None None None XRAY 2.098 0.182 0.224 A 362.0 350.0 0 31 31 0 [[25, 313]] 1.0 4fmq Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.3e-86 293.7 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4NIFB P28482 9 360 360.0 ANP:401 ATPlike Inactive DFGin 6.7638 15.4088 BLAminus -131.87, -169.42 69.51, 63.01 -98.39, 22.71 281.57, 68.87 -63.28, -26.61 in-in in 9.0075 Saltbr-in 2.7834 HRD-in -68.77, -49.09 76.18, -3.84 in-in-out SNCiio in-out ActLoopNT-in 2.7275 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -127.8, 161.08 APE9-dihe-na -75.51, -26.3 APE8-dihe-in -152.23, 138.84 APE8-rot-out 180.18 APE67-dihe-in -71.26, -8.82 -111.88, 5.33 APE12-dist-in 8.1996 APE11-dist-in 11.9615 APE10-dist-out 8.903 APE9-dist-out 11.5131 None None None XRAY 2.15 0.161 0.208 B 362.0 349.0 3 31 28 3 [[25, 313]] 1.0 4nif Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.3e-86 293.7 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4NIFE P28482 10 360 360.0 ANP:401 ATPlike Inactive DFGin 6.7991 15.6006 BLAminus -132.52, -168.43 65.68, 64.41 -97.79, 21.09 277.61, 67.0 -63.55, -23.2 in-in in 9.1704 Saltbr-in 2.7133 HRD-in -70.38, -48.01 73.58, -2.52 in-in-out SNCiio in-out ActLoopNT-in 2.7288 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -128.04, 157.14 APE9-dihe-na -71.47, -27.38 APE8-dihe-in -153.58, 137.78 APE8-rot-out 179.37 APE67-dihe-in -68.22, -5.95 -110.7, 4.02 APE12-dist-in 8.1436 APE11-dist-in 11.9289 APE10-dist-out 8.9408 APE9-dist-out 11.5278 None None None XRAY 2.15 0.161 0.208 E 362.0 348.0 3 31 28 3 [[25, 313]] 1.0 4nif Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.3e-86 293.7 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8PSRA P28482 1 358 360.0 ANP:401 ATPlike Inactive DFGin 6.7627 15.1158 BLAminus -130.96, -167.28 68.25, 62.57 -95.64, 20.11 282.69, 71.74 -68.98, -15.25 in-in in 8.941 Saltbr-in 2.8232 HRD-in -68.74, -46.55 75.16, -5.99 in-in-out SNCiio in-out ActLoopNT-in 2.7689 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -133.02, 153.53 APE9-dihe-na -66.89, -30.36 APE8-dihe-in -146.2, 134.03 APE8-rot-out 178.25 APE67-dihe-in -71.02, -10.13 -100.56, 5.83 APE12-dist-in 8.1678 APE11-dist-in 11.5467 APE10-dist-out 8.8891 APE9-dist-out 11.3605 None None None XRAY 1.85 0.183 0.209 A 364.0 354.0 4 31 27 4 [[25, 313]] 1.0 8psr Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 3TEIA P28482 10 358 360.0 ANP:401 ATPlike Inactive DFGin 6.743 15.9468 BLAminus -130.8, -176.53 59.31, 74.36 -93.64, 10.5 288.08, 72.41 -50.44, -31.09 in-in in 9.2714 Saltbr-in 3.1994 HRD-in -69.93, -52.25 74.6, -17.82 in-in-out SNCiio in-out ActLoopNT-in 2.7526 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na 66.02, 77.59 APE9-dihe-na -53.11, -45.5 APE8-dihe-in -109.04, 134.77 APE8-rot-out 40.2 APE67-dihe-in -60.63, -33.66 -94.81, 4.48 APE12-dist-in 8.7836 APE11-dist-in 10.9926 APE10-dist-out 8.5071 APE9-dist-out 11.1823 R77A,E314A None None XRAY 2.404 0.199 0.235 A 362.0 339.0 10 31 24 7 [[25, 313]] 1.0 3tei Homo sapiens CMGC_MAPK1_HUMAN CMGC 1.6e-85 292.9 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4H3PA P28482 11 359 360.0 ANP:401 ATPlike Inactive DFGin 6.7486 16.129 BLAminus -129.02, -179.26 65.06, 71.95 -98.46, 28.28 294.01, 75.31 -57.14, -23.59 in-in in 9.6015 Saltbr-in 3.0521 HRD-in -79.45, -54.12 78.74, 4.99 in-in-out SNCiio in-out ActLoopNT-in 2.7274 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -109.42, 169.7 APE9-dihe-na -56.98, -72.96 APE8-dihe-in -103.33, 144.18 APE8-rot-out 6.69 APE67-dihe-in -56.41, -28.74 -91.67, -5.29 APE12-dist-in 8.8946 APE11-dist-in 9.1851 APE10-dist-out 8.3832 APE9-dist-out 9.7322 R77A,E314A None None XRAY 2.3 0.18 0.224 A 362.0 342.0 7 31 24 7 [[25, 313]] 1.0 4h3p Homo sapiens CMGC_MAPK1_HUMAN CMGC 1.6e-85 292.9 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4H3PD P28482 11 359 360.0 ANP:401 ATPlike Inactive DFGin 6.7423 16.2695 BLAminus -128.42, -178.25 63.92, 70.53 -94.38, 28.0 287.67, 73.89 -60.9, -21.54 in-in in 9.383 Saltbr-in 3.4542 HRD-in -75.51, -54.76 82.18, -2.55 in-in-out SNCiio in-out ActLoopNT-in 2.6568 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 42.36 APE8-rot-out 66.34 APE67-dihe-in -61.9, -28.03 -63.57, -9.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 R77A,E314A None None XRAY 2.3 0.18 0.224 D 362.0 338.0 11 31 20 11 [[25, 313]] 1.0 4h3p Homo sapiens CMGC_MAPK1_HUMAN CMGC 1.6e-85 292.9 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8PT0A P28482 11 358 360.0 ANP:401,EAI:403 ATPlike,Allosteric Inactive DFGin 6.7034 15.5181 BLAminus -130.99, -173.26 73.92, 62.07 -95.1, 17.63 279.55, 70.77 -68.45, -13.49 in-in in 9.1413 Saltbr-in 2.8701 HRD-in -71.96, -48.9 77.41, -4.12 in-in-out SNCiio in-out ActLoopNT-in 2.6924 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -110.07, -36.78 APE9-dihe-na -83.86, 177.79 APE8-dihe-in -68.52, 145.31 APE8-rot-out 191.04 APE67-dihe-in -66.51, -15.78 -105.25, 7.42 APE12-dist-out 6.875 APE11-dist-in 12.4434 APE10-dist-out 12.5541 APE9-dist-out 9.9942 None None None XRAY 1.65 0.178 0.207 A 364.0 348.0 0 31 31 0 [[25, 313]] 1.0 8pt0 Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8PT1A P28482 11 359 360.0 ANP:401,E2A:402 ATPlike,Allosteric Inactive DFGin 6.7525 15.486 BLAminus -130.01, -175.04 73.39, 64.08 -95.46, 18.76 282.28, 68.91 -63.67, -19.55 in-in in 9.1894 Saltbr-in 2.8492 HRD-in -70.21, -47.68 76.07, -5.14 in-in-out SNCiio in-out ActLoopNT-in 2.6722 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -121.06, -17.86 APE9-dihe-na -106.9, -177.78 APE8-dihe-in -78.1, 145.34 APE8-rot-out 186.54 APE67-dihe-in -67.62, -15.27 -108.68, 6.96 APE12-dist-in 7.1713 APE11-dist-in 12.6151 APE10-dist-out 12.6307 APE9-dist-out 10.2747 None None None XRAY 1.8 0.18 0.206 A 364.0 349.0 0 31 31 0 [[25, 313]] 1.0 8pt1 Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8PT5A P28482 10 358 360.0 ANP:401,D5R:402 ATPlike,Allosteric Inactive DFGin 6.7902 15.3041 BLAminus -138.03, -165.34 60.19, 62.86 -94.09, 21.06 289.01, 63.44 -59.86, -23.15 in-in in 9.091 Saltbr-in 2.8817 HRD-in -75.18, -47.36 71.89, 2.28 in-in-out SNCiio in-out ActLoopNT-in 2.6856 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -138.15, 158.79 APE9-dihe-na -71.62, -19.38 APE8-dihe-in -154.23, 140.23 APE8-rot-out 183.5 APE67-dihe-in -63.22, -13.66 -125.12, 20.04 APE12-dist-in 7.6307 APE11-dist-in 11.4685 APE10-dist-out 8.7388 APE9-dist-out 11.2872 None None None XRAY 1.95 0.206 0.235 A 364.0 336.0 10 31 21 10 [[25, 313]] 1.0 8pt5 Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8R5FA P28482 11 359 360.0 ANP:401,Y3H:403 ATPlike,Allosteric Inactive DFGin 6.7147 15.4588 BLAminus -133.12, -173.02 67.59, 67.52 -98.89, 23.72 283.56, 67.1 -69.6, -17.36 in-in in 9.1414 Saltbr-in 2.9066 HRD-in -75.1, -48.03 76.68, -4.69 in-in-out SNCiio in-out ActLoopNT-in 2.6928 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -92.27 APE8-dihe-in -89.34, 137.7 APE8-rot-out 190.9 APE67-dihe-in -68.19, -17.69 -92.76, -0.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.6172 None None None XRAY 1.65 0.194 0.218 A 364.0 337.0 12 31 19 12 [[25, 313]] 1.0 8r5f Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8PT3A P28482 10 359 360.0 D7O:401,ANP:405 Allosteric,ATPlike Inactive DFGin 6.7463 16.2954 BLAminus -133.05, 179.18 60.24, 82.09 -94.36, 25.54 283.73, 70.47 -58.59, -24.6 in-out in 9.2783 Saltbr-out 4.0942 HRD-in -70.52, -51.82 77.79, -2.53 out-in-out SNCoio in-out ActLoopNT-in 2.7512 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oiio APE10-dihe-na -134.69, 123.91 APE9-dihe-na -78.34, -33.65 APE8-dihe-in -152.41, 145.11 APE8-rot-out 185.39 APE67-dihe-in -63.56, -20.16 -105.73, 9.6 APE12-dist-out 6.368 APE11-dist-in 8.5922 APE10-dist-in 7.9732 APE9-dist-out 9.8583 None None None XRAY 1.8 0.189 0.222 A 364.0 344.0 6 31 25 6 [[25, 313]] 1.0 8pt3 Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK10 MK10_HUMAN 8WGFA P53779 44 400 464.0 ANP:60401 ATPlike Inactive DFGin 3.6694 14.0402 ABAminus -79.02, -31.55 -136.84, 175.04 -119.07, 8.28 296.56, 96.93 82.35, -157.09 in-out in 9.3841 Saltbr-out 5.0182 HRD-in -58.91, -63.96 74.85, 1.04 out-out-out SNCooo out-out ActLoopNT-out 7.3249 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -90.96, 137.03 APE9-dihe-na -73.55, 128.96 APE8-dihe-in -72.45, 116.03 APE8-rot-in 306.62 APE67-dihe-in -62.34, -20.8 -105.53, -9.26 APE12-dist-out 20.9534 APE11-dist-out 15.692 APE10-dist-out 16.3743 APE9-dist-out 11.0217 None None None XRAY 1.85 0.212 0.266 A 364.0 345.0 4 27 23 4 [[64, 359]] 1.0 8wgf Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1.0 301.0 301.0 206 207 208 210 212 93 111 115 186 188 187 189.0 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 1JNKA P53779 45 400 464.0 ANP:1001 ATPlike Inactive DFGin 3.9285 14.3968 ABAminus -78.22, -57.34 -98.44, 177.55 -110.1, 6.65 294.57, 85.06 91.46, -137.75 in-out in 9.6832 Saltbr-out 4.0755 HRD-in -45.57, -68.64 69.61, 1.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -66.55, 160.68 APE9-dihe-na -118.58, 134.57 APE8-dihe-in -89.41, 118.53 APE8-rot-in 305.71 APE67-dihe-in -40.1, -24.2 -103.88, -20.46 APE12-dist-out 21.3166 APE11-dist-out 17.8726 APE10-dist-out 16.7462 APE9-dist-out 11.4972 None None None XRAY 2.3 0.222 0.274 A 423.0 346.0 5 27 22 5 [[64, 359]] 1.0 1jnk Homo sapiens CMGC_MAPK10_HUMAN CMGC 2.3e-85 292.5 1.0 301.0 301.0 206 207 208 210 212 93 111 115 186 188 187 189.0 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 4Z9LA P53779 45 400 464.0 ANP:501,880:502 Allosteric,Type1 Inactive DFGin 4.1741 14.4447 ABAminus -84.27, -25.72 -124.69, 176.34 -117.02, 11.08 300.14, 92.59 64.94, -148.04 out-out out 10.0906 Saltbr-out 4.2056 HRD-in -57.93, -67.24 75.49, -7.3 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 141.12 APE8-dihe-in -74.24, 114.86 APE8-rot-in 306.24 APE67-dihe-in -45.55, -30.35 -108.57, -9.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.617 None None None XRAY 2.1 0.201 0.226 A 364.0 333.0 12 27 17 10 [[64, 359]] 1.0 4z9l Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1.0 301.0 301.0 206 207 208 210 212 93 111 115 186 188 187 189.0 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK12 MK12_HUMAN 1CM8A P53778 8 353 367.0 ANP:60400 ATPlike Active DFGin 6.9648 14.7742 BLAminus -109.08, -177.81 49.88, 82.62 -94.66, 21.96 279.65, 74.31 -61.38, -21.21 in-in in 9.0 Saltbr-in 2.7767 HRD-in -80.35, -48.18 64.34, 20.91 in-in-in SNCiii in-in ActLoopNT-in 2.7927 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.88, 159.85 APE9-dihe-na 73.62, 141.22 APE8-dihe-in -70.32, 134.6 APE8-rot-in 295.09 APE67-dihe-in -62.17, -12.08 -34.13, -61.33 APE12-dist-in 11.6036 APE11-dist-in 10.9558 APE10-dist-in 6.9911 APE9-dist-in 3.072 None TPO183,PTR185 TPO183,PTR185 XRAY 2.4 0.232 0.283 A 367.0 329.0 6 25 25 0 [[27, 311]] 1.0 1cm8 Homo sapiens CMGC_MAPK12_HUMAN CMGC 5.6e-85 291.2 1.0 301.0 301.0 170 171 172 174 176 56 74 78 150 152 151 153.0 208 195 190 189 188 187 186 185 184 110 Mitogen-activated protein kinase 12
CMGC MAPK12 MK12_HUMAN 1CM8B P53778 8 353 367.0 ANP:61400 ATPlike Active DFGin 6.9649 14.7941 BLAminus -106.93, -177.79 50.51, 81.99 -94.3, 22.09 279.91, 74.94 -61.07, -21.75 in-in in 9.0314 Saltbr-in 2.7588 HRD-in -80.7, -47.04 63.03, 19.82 in-in-in SNCiii in-in ActLoopNT-in 2.8171 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.88, 160.62 APE9-dihe-na 73.12, 141.25 APE8-dihe-in -70.38, 133.34 APE8-rot-in 295.67 APE67-dihe-in -62.05, -11.85 -33.55, -61.0 APE12-dist-in 11.6132 APE11-dist-in 10.95 APE10-dist-in 6.9956 APE9-dist-in 3.0483 None TPO183,PTR185 TPO183,PTR185 XRAY 2.4 0.232 0.283 B 367.0 329.0 6 25 25 0 [[27, 311]] 1.0 1cm8 Homo sapiens CMGC_MAPK12_HUMAN CMGC 5.6e-85 291.2 1.0 301.0 301.0 170 171 172 174 176 56 74 78 150 152 151 153.0 208 195 190 189 188 187 186 185 184 110 Mitogen-activated protein kinase 12
CMGC MAPK7 MK07_HUMAN 4IC7A Q13164 46 400 816.0 ANP:60501 ATPlike Inactive DFGin 6.9627 15.7065 BLAminus -112.54, -170.45 61.6, 71.09 -94.22, 5.13 285.3, 80.28 -60.77, -23.83 in-in in 9.4498 Saltbr-in 2.9107 HRD-in -64.26, -48.71 75.06, -19.07 in-in-out SNCiio in-out ActLoopNT-in 3.1841 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na 163.57, 152.54 APE9-dihe-na -166.15, 155.73 APE8-dihe-in -57.6, 140.19 APE8-rot-out 163.75 APE67-dihe-in -65.59, -38.02 -73.56, -13.59 APE12-dist-in 8.8302 APE11-dist-out 6.3379 APE10-dist-out 8.5089 APE9-dist-in 5.809 None None None XRAY 2.6 0.213 0.258 A 442.0 355.0 0 32 32 0 [[55, 347]] 1.0 4ic7 Homo sapiens CMGC_MAPK7_HUMAN CMGC 1.4e-81 280.1 1.0 301.0 301.0 199 200 201 203 205 84 102 106 179 181 180 182.0 244 231 226 225 224 223 222 221 220 138 Mitogen-activated protein kinase 7
CMGC MAPK7 MK07_HUMAN 4IC7D Q13164 47 399 816.0 ANP:60501 ATPlike Inactive DFGin 6.9213 15.4911 BLAminus -111.52, -167.35 56.73, 75.91 -99.28, 4.79 286.66, 84.61 -57.3, -28.24 in-in in 9.3823 Saltbr-in 3.2739 HRD-in -69.27, -53.54 75.02, -19.96 in-in-out SNCiio in-out ActLoopNT-in 3.0429 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -103.14, 107.5 APE9-dihe-na -135.73, 156.83 APE8-dihe-in -63.07, 155.1 APE8-rot-out 142.76 APE67-dihe-in -57.29, -43.39 -78.84, -17.33 APE12-dist-in 8.8303 APE11-dist-out 6.9807 APE10-dist-out 8.3506 APE9-dist-in 5.5697 None None None XRAY 2.6 0.213 0.258 D 442.0 353.0 0 32 32 0 [[55, 347]] 1.0 4ic7 Homo sapiens CMGC_MAPK7_HUMAN CMGC 1.4e-81 280.1 1.0 301.0 301.0 199 200 201 203 205 84 102 106 179 181 180 182.0 244 231 226 225 224 223 222 221 220 138 Mitogen-activated protein kinase 7
CMGC MAPK8 MK08_HUMAN 6ZR5A P45983 3 362 427.0 ANP:60402 ATPlike Inactive DFGin 3.8172 14.2258 ABAminus -84.03, -42.55 -114.88, 174.79 -114.82, 8.54 299.13, 101.86 79.5, -168.62 out-out out 10.0023 Saltbr-out 5.0314 HRD-in -56.29, -55.44 70.4, -2.27 out-out-out SNCooo out-out ActLoopNT-out 6.8722 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 107.14 APE8-rot-out 87.08 APE67-dihe-in -67.28, -21.26 -101.91, 26.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.699 0.186 0.256 A 366.0 348.0 12 27 15 12 [[26, 321]] 1.0 6zr5 Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 6ZR5B P45983 4 362 427.0 ANP:60400 ATPlike Inactive DFGin 3.867 14.0721 ABAminus -85.51, -41.13 -110.19, 172.79 -115.96, 8.05 294.61, 92.39 79.48, -170.78 out-out out 10.0205 Saltbr-out 4.2237 HRD-in -59.93, -50.9 67.15, -3.15 out-out-out SNCooo out-out ActLoopNT-out 6.8489 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -100.6, 89.98 APE9-dihe-na -140.16, 151.66 APE8-dihe-in -87.57, 109.71 APE8-rot-in 298.46 APE67-dihe-in -73.45, -13.54 -100.12, 16.22 APE12-dist-out 17.5514 APE11-dist-in 12.8984 APE10-dist-out 16.3414 APE9-dist-out 11.496 None None None XRAY 2.699 0.186 0.256 B 366.0 359.0 0 27 27 0 [[26, 321]] 1.0 6zr5 Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 2XRWA P45983 2 364 427.0 ANP:61367 ATPlike Inactive DFGin 3.8162 13.9414 ABAminus -85.3, -24.5 -153.59, -177.02 -115.68, 7.02 304.14, 97.05 88.01, -156.78 in-out in 9.886 Saltbr-out 4.6349 HRD-in -83.3, -58.4 77.36, -14.29 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.45, -23.57 999.0, -3.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.33 0.166 0.187 A 371.0 347.0 16 27 11 16 [[26, 321]] 1.0 2xrw Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.5e-85 290.5 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 2XS0A P45983 6 365 427.0 ANP:1367 ATPlike Inactive DFGin 3.7537 14.0806 ABAminus -75.25, -22.88 -148.14, -178.22 -116.01, 26.92 303.04, 86.85 61.81, -161.42 in-out in 9.7349 Saltbr-out 5.5498 HRD-in -69.33, -60.51 78.49, -20.02 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 173.45 APE8-rot-out 188.87 APE67-dihe-out -73.26, -26.46 -135.55, 95.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T183V,Y185F None None XRAY 2.6 0.194 0.246 A 386.0 346.0 14 27 13 14 [[26, 321]] 1.0 2xs0 Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.5e-83 284.9 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 4UX9A P45983 8 363 427.0 ANP:1000 ATPlike Inactive DFGin 6.5081 13.5979 ABAminus -106.9, -65.56 -75.5, 125.74 -123.36, 16.47 304.33, 124.23 -68.62, -34.25 in-out in 8.8495 Saltbr-out 3.6733 HRD-in -62.88, -46.37 73.76, -28.18 out-in-in SNCoii in-in ActLoopNT-in 2.694 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -77.3, -23.46 APE9-dihe-na -71.58, 140.2 APE8-dihe-in -64.86, 127.48 APE8-rot-in 308.5 APE67-dihe-in -60.43, -26.76 -33.69, -61.49 APE12-dist-in 11.784 APE11-dist-in 12.4258 APE10-dist-in 6.6314 APE9-dist-in 4.5326 None None None XRAY 2.34 0.202 0.24 A 364.0 343.0 7 27 22 5 [[26, 321]] 1.0 4ux9 Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 4UX9C P45983 8 363 427.0 ANP:1000 ATPlike Inactive DFGin 6.9564 13.7764 ABAminus -110.49, -64.95 -89.1, 120.63 -119.14, 21.23 309.02, 115.06 -68.23, -26.49 in-out in 8.9193 Saltbr-out 3.6356 HRD-in -66.22, -47.15 71.23, -16.82 out-in-none SNCoin in-none ActLoopNT-in 2.5691 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -79.69, -26.4 APE9-dihe-na -76.07, 142.18 APE8-dihe-in -66.37, 127.01 APE8-rot-in 305.02 APE67-dihe-in -64.57, -24.76 -35.27, -55.26 APE12-dist-none 999.0 APE11-dist-in 12.0054 APE10-dist-in 6.5305 APE9-dist-in 4.6212 None None None XRAY 2.34 0.202 0.24 C 364.0 333.0 15 27 20 7 [[26, 321]] 1.0 4ux9 Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 4UX9D P45983 9 364 427.0 ANP:1000 ATPlike Inactive DFGin 6.7553 13.4065 ABAminus -120.6, -55.98 -93.07, 108.1 -98.68, 25.97 301.07, 117.04 -64.8, -33.9 in-in in 9.3656 Saltbr-in 2.7382 HRD-in -59.8, -49.61 70.57, -12.64 in-in-out SNCiio in-out ActLoopNT-in 2.6695 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oioo APE10-dihe-na -95.31, 105.19 APE9-dihe-na -74.34, -56.46 APE8-dihe-in -76.71, 134.72 APE8-rot-out 95.68 APE67-dihe-out -66.63, -26.9 -139.86, 50.27 APE12-dist-out 14.0313 APE11-dist-in 13.438 APE10-dist-out 10.8234 APE9-dist-out 13.5554 None None None XRAY 2.34 0.202 0.24 D 364.0 344.0 9 27 27 0 [[26, 321]] 1.0 4ux9 Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 8R5EA P45983 5 363 427.0 ANP:402,Y6K:403 ATPlike,Allosteric Inactive DFGin 4.2147 13.8837 ABAminus -92.07, -26.65 -133.67, 178.16 -123.93, 6.5 294.94, 97.33 89.15, -162.77 in-out in 9.5208 Saltbr-out 4.8419 HRD-in -77.17, -59.97 76.05, -10.25 out-out-out SNCooo out-out ActLoopNT-out 6.7895 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -62.14, 143.17 APE9-dihe-na -120.32, 118.65 APE8-dihe-in -75.39, 123.94 APE8-rot-in 299.29 APE67-dihe-in -61.41, -23.9 -115.12, 4.11 APE12-dist-out 18.7072 APE11-dist-out 15.3251 APE10-dist-out 16.6803 APE9-dist-out 11.2441 None None None XRAY 1.7 0.177 0.222 A 366.0 359.0 0 27 27 0 [[26, 321]] 1.0 8r5e Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 4QTDA P45983 6 363 427.0 38Z:424,ANP:425 Type1,Allosteric Inactive DFGin 4.2787 13.95 ABAminus -89.69, -21.2 -135.34, 171.77 -115.48, 9.24 298.02, 89.8 87.52, -156.74 in-out in 9.5926 Saltbr-out 4.1531 HRD-in -75.36, -55.62 72.51, -12.26 out-out-out SNCooo out-out ActLoopNT-out 6.6893 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -117.32, 137.81 APE9-dihe-na -80.42, 132.23 APE8-dihe-in -83.54, 120.1 APE8-rot-in 296.41 APE67-dihe-in -61.39, -20.52 -109.55, -3.05 APE12-dist-out 21.1401 APE11-dist-out 16.032 APE10-dist-out 16.5166 APE9-dist-out 11.1471 None None None XRAY 1.5 0.167 0.192 A 364.0 355.0 3 27 24 3 [[26, 321]] 1.0 4qtd Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 9FT9A P45983 7 363 427.0 ANP:401 ATPlike Inactive DFGin 6.2012 13.6807 BLAminus -138.37, -170.04 58.94, 78.24 -92.66, 22.82 315.32, 103.73 -63.89, -26.18 in-out in 8.5419 Saltbr-out 3.8425 HRD-in -66.92, -47.02 65.13, 0.51 out-in-out SNCoio in-out ActLoopNT-in 2.8271 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -150.17, 156.5 APE9-dihe-na -75.27, -52.01 APE8-dihe-in -88.35, 100.07 APE8-rot-in 310.81 APE67-dihe-in -64.72, -11.39 -102.84, 1.94 APE12-dist-out 5.9095 APE11-dist-in 10.5805 APE10-dist-out 8.0786 APE9-dist-out 10.9491 None None None XRAY 2.35 0.234 0.27 A 360.0 357.0 0 27 27 0 [[26, 321]] 1.0 9ft9 Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.1e-84 288.2 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 4UX9B P45983 8 362 427.0 ANP:1000 ATPlike Inactive DFGin 6.8269 14.0009 None -95.23, -79.97 -82.17, 124.02 -113.22, 13.68 297.81, 107.19 -60.29, -32.64 in-in in 8.6029 Saltbr-in 2.9418 HRD-in -59.44, -53.0 79.08, -24.85 in-in-in SNCiii in-in ActLoopNT-in 2.5822 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -58.47, -40.48 APE9-dihe-na -78.17, 138.93 APE8-dihe-in -64.59, 122.35 APE8-rot-in 308.57 APE67-dihe-in -67.83, -19.56 -32.59, -57.13 APE12-dist-in 12.3608 APE11-dist-in 12.1486 APE10-dist-in 6.5271 APE9-dist-in 4.6911 None None None XRAY 2.34 0.202 0.24 B 364.0 327.0 14 27 21 6 [[26, 321]] 1.0 4ux9 Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC PRP4K PRP4K_HUMAN 4IIRA Q13523 668 1005 1007.0 ANP:1101 ATPlike Inactive DFGin 6.3148 14.281 BLAminus -120.02, 179.88 56.46, 83.55 -99.74, 23.13 289.68, 86.8 -67.87, -30.41 in-in in 8.3392 Saltbr-in 2.9099 HRD-in -69.64, -43.63 60.41, 19.82 in-in-out SNCiio in-out ActLoopNT-in 2.7784 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -71.08, 135.09 APE9-dihe-na 76.0, 140.17 APE8-dihe-in -53.9, 125.75 APE8-rot-in 292.63 APE67-dihe-in -65.92, -24.69 -31.89, -51.26 APE12-dist-out 15.6632 APE11-dist-in 11.8049 APE10-dist-out 8.8915 APE9-dist-in 3.1936 None PTR849 PTR849 XRAY 2.0 0.244 0.265 A 358.0 326.0 12 26 26 0 [[687, 1003]] 1.0 4iir Homo sapiens CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1.0 301.0 301.0 833 834 835 837 839 717 732 736 812 814 813 815.0 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
CMGC PRP4K PRP4K_HUMAN 4IIRB Q13523 670 1005 1007.0 ANP:1101 ATPlike Inactive DFGin 6.3122 13.999 BLAminus -118.84, -178.78 57.41, 86.51 -103.95, 25.37 293.04, 89.03 -68.57, -33.53 in-in in 8.4814 Saltbr-in 2.7949 HRD-in -68.12, -42.18 57.06, 24.08 in-in-out SNCiio in-out ActLoopNT-in 2.8044 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -73.62, 140.27 APE9-dihe-na 75.42, 141.56 APE8-dihe-in -56.4, 124.9 APE8-rot-in 292.41 APE67-dihe-in -64.45, -24.58 -31.45, -51.6 APE12-dist-out 15.6019 APE11-dist-in 11.8119 APE10-dist-out 8.6042 APE9-dist-in 3.2188 None PTR849 PTR849 XRAY 2.0 0.244 0.265 B 358.0 328.0 8 26 26 0 [[687, 1003]] 1.0 4iir Homo sapiens CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1.0 301.0 301.0 833 834 835 837 839 717 732 736 812 814 813 815.0 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
CMGC SRPK1 SRPK1_HUMAN 3BEGA Q96SB4 69 655 655.0 ANP:656 ATPlike Inactive DFGin 5.24 13.8456 BLAminus -114.77, -153.39 33.98, 76.85 -81.15, -2.34 268.31, 108.69 -69.77, 18.55 in-none in 9.9994 Saltbr-none 999.0 HRD-in -104.12, -37.12 72.24, -11.76 none-in-out SNCnio in-out ActLoopNT-in 3.2846 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -116.54, 166.61 APE9-dihe-na 69.15, 140.92 APE8-dihe-in -77.27, 142.01 APE8-rot-out 16.0 APE67-dihe-in -60.83, 1.46 -31.99, -68.49 APE12-dist-in 12.9949 APE11-dist-in 10.441 APE10-dist-in 7.8352 APE9-dist-in 3.0622 None None None XRAY 2.9 0.24 0.298 A 381.0 348.0 21 25 25 0 [[80, 653]] 1.0 3beg Homo sapiens CMGC_SRPK1_HUMAN CMGC 1.7e-139 470.1 1.0 301.0 301.0 496 497 498 500 502 109 124 128 210 212 211 213.0 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
OTHER EIF2AK2 E2AK2_HUMAN 2A19B P19525 258 541 551.0 ANP:61640 ATPlike Inactive DFGin 6.2846 14.3355 ABAminus -120.94, -28.83 -115.8, 107.84 -103.04, 22.08 287.72, 80.44 -61.97, -26.4 in-in in 8.2475 Saltbr-in 2.7306 HRD-in -80.45, -51.29 75.68, -7.45 in-in-out SNCiio in-out ActLoopNT-in 3.0605 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -131.92, 139.76 APE9-dihe-na 107.67, -147.72 APE8-dihe-in -73.7, 128.56 APE8-rot-out 9.97 APE67-dihe-in -50.1, -40.95 -103.24, -6.7 APE12-dist-in 12.5447 APE11-dist-in 10.8413 APE10-dist-out 10.3359 APE9-dist-out 9.8523 H412N,C551A TPO446 TPO446 XRAY 2.5 0.234 0.286 B 284.0 262.0 9 27 27 0 [[175, 537]] 1.0 2a19 Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 6.2e-47 166.4 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 2A19C P19525 258 541 551.0 ANP:62640 ATPlike Inactive DFGin 6.9406 14.5579 ABAminus -118.27, -31.05 -99.56, 112.7 -116.24, 24.93 286.16, 84.97 -61.15, -35.53 in-in in 7.6955 Saltbr-in 3.4222 HRD-out -95.69, 102.36 -63.67, -30.07 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 H412N,C551A TPO446 TPO446 XRAY 2.5 0.234 0.286 C 284.0 202.0 69 27 5 22 [[175, 537]] 1.0 2a19 Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 6.2e-47 166.4 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER TP53RK PRPK_HUMAN 6WQXC Q96S44 17 247 253.0 ANP:301 ATPlike Active DFGin 5.9501 14.2511 BLAminus -146.19, 177.42 55.9, 80.94 -109.82, 15.46 288.95, 83.65 -50.48, -21.92 in-in in 7.4927 Saltbr-in 2.923 HRD-in -69.98, -47.0 96.04, -14.43 in-in-na SNCiia in-na ActLoopNT-in 2.8045 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -67.54, -42.02 APE9-dihe-na -66.2, -40.19 APE8-dihe-na -55.79, -43.62 APE8-rot-na 183.14 APE67-dihe-na -65.72, -35.03 -54.78, -48.19 APE12-dist-na 16.7237 APE11-dist-na 12.0355 APE10-dist-na 14.5766 APE9-dist-na 11.7405 None None None XRAY 2.53 0.214 0.265 C 267.0 231.0 6 23 23 0 [[32, 253]] 1.0 6wqx Homo sapiens OTHER_TP53RK_HUMAN TP53RK 1.2e-114 387.3 1.0 224.0 224.0 182 183 184 186 188 60 84 88 159 161 160 162.0 199 205 200 199 198 197 196 195 194 114 EKC/KEOPS complex subunit TP53RK
OTHER TP53RK PRPK_HUMAN 6WQXD Q96S44 18 247 253.0 ANP:301 ATPlike Active DFGin 6.0426 14.258 BLAminus -133.24, 171.19 66.42, 73.64 -108.34, 16.47 289.91, 91.17 -66.2, -15.73 in-in in 7.3772 Saltbr-in 2.5054 HRD-in -60.03, -49.96 100.64, -20.8 in-in-na SNCiia in-na ActLoopNT-in 2.8161 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -66.35, -39.45 APE9-dihe-na -58.51, -49.84 APE8-dihe-na -58.36, -37.8 APE8-rot-na 168.78 APE67-dihe-na -71.45, -37.84 -63.19, -40.46 APE12-dist-na 16.6763 APE11-dist-na 12.0705 APE10-dist-na 14.4989 APE9-dist-na 11.4693 None None None XRAY 2.53 0.214 0.265 D 267.0 230.0 6 23 23 0 [[32, 253]] 1.0 6wqx Homo sapiens OTHER_TP53RK_HUMAN TP53RK 1.2e-114 387.3 1.0 224.0 224.0 182 183 184 186 188 60 84 88 159 161 160 162.0 199 205 200 199 198 197 196 195 194 114 EKC/KEOPS complex subunit TP53RK
OTHER WNK1 WNK1_HUMAN 5WDYA Q9H4A3 208 481 2382.0 ANP:901,A6S:902 ATPlike,Type3 None DFGin 7.9646 14.3105 BLAminus -123.5, -167.41 55.36, 79.67 -97.29, 28.92 280.94, 63.73 -64.29, -44.25 out-na out 15.4122 Saltbr-na 999.0 HRD-in -68.16, -49.86 71.58, -14.71 na-in-none SNCain in-none ActLoopNT-in 3.0135 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -108.13, -60.96 999.0, 157.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S378D,E396A,E397A,K398A None None XRAY 2.458 0.231 0.285 A 279.0 260.0 14 26 17 9 [[220, 479]] 1.0 5wdy Homo sapiens OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 5WDYB Q9H4A3 206 480 2382.0 ANP:502,A6S:503 ATPlike,Type3 Inactive DFGin 7.3697 14.5039 BLAminus -142.95, -168.2 54.59, 81.56 -95.94, 38.03 311.01, 0.7 -70.23, -38.22 out-na out 15.6644 Saltbr-na 999.0 HRD-in -73.48, -49.35 66.41, -10.51 na-in-out SNCaio in-out ActLoopNT-in 2.8562 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -28.04 APE8-rot-out 62.13 APE67-dihe-out -96.17, -54.53 -53.63, 160.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S378D,E396A,E397A,K398A None None XRAY 2.458 0.231 0.285 B 279.0 259.0 16 26 17 9 [[220, 479]] 1.0 5wdy Homo sapiens OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 5WE8A Q9H4A3 209 483 2382.0 ANP:502,A7Y:503 ATPlike,Type3 Inactive DFGin 7.2406 14.0323 BLAminus -121.41, -171.4 57.02, 71.32 -89.03, 25.94 306.74, 15.86 -67.83, -33.81 out-na out 15.5061 Saltbr-na 999.0 HRD-in -66.1, -48.39 70.94, -12.37 na-in-out SNCaio in-out ActLoopNT-in 2.8473 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -77.54, 145.45 APE9-dihe-na 132.01, 166.25 APE8-dihe-in -145.73, 139.85 APE8-rot-out 178.66 APE67-dihe-out -92.59, -40.75 -69.19, 149.7 APE12-dist-out 20.1345 APE11-dist-out 22.4082 APE10-dist-out 25.4016 APE9-dist-out 25.9281 S378D,E396A,E397A,K398A None None XRAY 2.006 0.205 0.247 A 279.0 270.0 5 26 26 0 [[220, 479]] 1.0 5we8 Homo sapiens OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 5WE8B Q9H4A3 207 480 2382.0 ANP:502,A7Y:503 ATPlike,Type3 Inactive DFGin 7.5758 14.7327 BLAminus -124.5, -174.3 56.61, 76.82 -93.57, 20.89 272.49, 56.06 -64.65, -35.23 out-na out 15.2517 Saltbr-na 999.0 HRD-in -64.68, -49.22 72.3, -10.07 na-in-out SNCaio in-out ActLoopNT-in 2.8196 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -86.7, 136.01 APE9-dihe-na 147.23, 150.88 APE8-dihe-in -131.74, 126.21 APE8-rot-in 297.77 APE67-dihe-out -91.94, -28.57 -59.79, 145.49 APE12-dist-out 19.935 APE11-dist-out 22.7259 APE10-dist-out 25.875 APE9-dist-out 25.6143 S378D,E396A,E397A,K398A None None XRAY 2.006 0.205 0.247 B 279.0 272.0 2 26 26 0 [[220, 479]] 1.0 5we8 Homo sapiens OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 5TF9A Q9H4A3 210 483 2382.0 7AV:501,ANP:502 Type3,ATPlike Inactive DFGin 7.7987 14.8055 BLAminus -124.68, -165.52 44.5, 74.88 -89.64, 28.71 274.12, 71.89 -66.6, -24.41 out-na out 15.6375 Saltbr-na 999.0 HRD-in -62.68, -52.45 73.71, -6.51 na-in-out SNCaio in-out ActLoopNT-in 2.8684 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 175.52 APE8-dihe-in -127.14, 129.36 APE8-rot-out 176.04 APE67-dihe-out -84.82, -53.84 -65.86, 145.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 27.0919 None None None XRAY 2.5 0.198 0.266 A 279.0 262.0 12 26 17 9 [[220, 479]] 1.0 5tf9 Homo sapiens OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 5TF9B Q9H4A3 206 480 2382.0 7AV:501,ANP:502 Type3,ATPlike Inactive DFGin 7.7453 14.5813 BLAminus -133.01, -172.41 51.04, 69.52 -83.58, 20.61 265.53, 72.73 -66.77, -27.15 out-na out 14.8615 Saltbr-na 999.0 HRD-in -69.24, -45.67 70.25, -7.52 na-in-out SNCaio in-out ActLoopNT-in 2.9022 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -166.32 APE8-dihe-in -143.09, 133.87 APE8-rot-in 278.07 APE67-dihe-out -99.53, -28.5 -65.98, 144.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 26.5987 None None None XRAY 2.5 0.198 0.266 B 279.0 266.0 9 26 17 9 [[220, 479]] 1.0 5tf9 Homo sapiens OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK3 WNK3_HUMAN 5O26A Q9BYP7 135 414 1800.0 ANP:501 ATPlike Active DFGin 6.9535 12.2012 BLAminus -125.28, -164.72 58.79, 65.89 -88.2, 18.66 305.61, 176.73 -69.56, -20.03 out-na out 15.8979 Saltbr-na 999.0 HRD-in -66.1, -48.87 66.45, 11.22 na-in-in SNCaii in-in ActLoopNT-in 3.0206 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.2, 167.0 APE9-dihe-na 127.63, -163.54 APE8-dihe-in -104.53, 119.98 APE8-rot-in 309.3 APE67-dihe-in -64.09, -19.44 -52.49, -34.59 APE12-dist-in 8.8729 APE11-dist-in 11.8288 APE10-dist-in 6.3262 APE9-dist-in 3.7059 None SEP304,SEP308 SEP304,SEP308 XRAY 2.379 0.231 0.278 A 284.0 273.0 7 26 26 0 [[146, 405]] 1.0 5o26 Homo sapiens OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1.0 260.0 260.0 293 294 295 297 299 176 194 198 272 274 273 275.0 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
OTHER WNK3 WNK3_HUMAN 5O26B Q9BYP7 136 413 1800.0 ANP:501 ATPlike Active DFGin 7.1821 12.0777 BLAminus -111.0, -167.63 57.49, 63.76 -86.7, 17.71 307.84, 173.05 -70.2, -27.96 out-na out 15.6411 Saltbr-na 999.0 HRD-in -66.99, -53.82 74.22, 8.4 na-in-in SNCaii in-in ActLoopNT-in 3.0727 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.41, 145.08 APE9-dihe-na 140.9, -162.45 APE8-dihe-in -99.46, 120.61 APE8-rot-in 305.94 APE67-dihe-in -65.71, -19.72 -54.06, -31.08 APE12-dist-in 8.1357 APE11-dist-in 11.827 APE10-dist-in 6.0436 APE9-dist-in 3.5099 None SEP304,SEP308 SEP304,SEP308 XRAY 2.379 0.231 0.278 B 284.0 267.0 11 26 26 0 [[146, 405]] 1.0 5o26 Homo sapiens OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1.0 260.0 260.0 293 294 295 297 299 176 194 198 272 274 273 275.0 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
STE MAP2K1 MP2K1_HUMAN 5YT3C Q02750 40 382 393.0 ANP:401 ATPlike Inactive DFGin 5.7908 13.7388 BLBplus -158.87, 169.48 60.29, 28.47 -79.68, 102.42 54.67, 117.74 -64.84, 999.0 out-none out 15.4948 Saltbr-none 999.0 HRD-in -68.06, -45.57 70.46, -13.87 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 133.64 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S218D,S222D,T292A,S298A None None XRAY 2.9 0.213 0.289 C 350.0 288.0 55 26 9 17 [[68, 361]] 1.0 5yt3 Homo sapiens STE_MAP2K1_HUMAN STE 4.7e-97 330.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 6V2WB Q02750 40 383 393.0 ANP:801 ATPlike Inactive DFGin 5.8394 13.8006 BLBplus -157.59, 169.08 49.06, 44.93 -84.24, 160.32 41.65, 89.8 -73.89, 81.99 out-out out 15.4976 Saltbr-out 15.9009 HRD-in -69.45, -57.02 68.3, 7.65 out-out-out SNCooo out-out ActLoopNT-out 8.701 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -54.4, 144.31 APE9-dihe-na -89.17, -161.86 APE8-dihe-out -115.14, -20.62 APE8-rot-out 48.82 APE67-dihe-out -139.36, 135.26 -146.31, 162.2 APE12-dist-out 17.533 APE11-dist-out 22.7363 APE10-dist-out 24.0164 APE9-dist-out 13.6453 S218A,S222A None None XRAY 3.12 0.189 0.237 B 397.0 312.0 32 26 26 0 [[68, 361]] 1.0 6v2w Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3SLSA Q02750 45 383 393.0 ANP:60400,77D:60500 ATPlike,Type3 Inactive DFGin 6.0671 13.8281 BLBplus -140.19, 178.66 54.09, 43.7 -94.25, 127.95 47.57, 97.28 -65.93, 145.27 out-out out 15.7649 Saltbr-out 16.2192 HRD-in -71.97, -60.22 78.51, -3.12 out-out-out SNCooo out-out ActLoopNT-out 8.4367 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nooo APE10-dihe-na -93.38, -0.96 APE9-dihe-na -118.58, -150.08 APE8-dihe-out -118.64, -9.13 APE8-rot-out 48.38 APE67-dihe-out -141.57, 136.87 -142.17, 156.77 APE12-dist-none 999.0 APE11-dist-out 20.7273 APE10-dist-out 20.2954 APE9-dist-out 13.9168 None None None XRAY 2.3 0.21 0.287 A 304.0 288.0 7 26 20 6 [[68, 361]] 1.0 3sls Homo sapiens STE_MAP2K1_HUMAN STE 1.4e-98 335.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3SLSB Q02750 45 383 393.0 ANP:60400,77D:60500 ATPlike,Type3 Inactive DFGin 6.2211 13.8152 BLBplus -143.68, 175.58 56.27, 41.79 -94.32, 130.27 43.79, 91.06 -64.4, 146.65 out-out out 15.8164 Saltbr-out 15.9268 HRD-in -71.99, -58.98 74.88, -1.55 out-out-out SNCooo out-out ActLoopNT-out 7.5058 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nooo APE10-dihe-na -110.34, -17.81 APE9-dihe-na 107.94, -164.16 APE8-dihe-out -114.29, -25.66 APE8-rot-out 168.01 APE67-dihe-out -146.37, 136.37 -123.32, 171.0 APE12-dist-none 999.0 APE11-dist-out 19.1374 APE10-dist-out 21.3033 APE9-dist-out 13.5951 None None None XRAY 2.3 0.21 0.287 B 304.0 290.0 5 26 21 5 [[68, 361]] 1.0 3sls Homo sapiens STE_MAP2K1_HUMAN STE 1.4e-98 335.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B3MA Q02750 37 382 393.0 ANP:60402,SU5:60403 ATPlike,Type3 Inactive DFGin 6.1258 13.3704 BLBplus -148.65, 168.81 60.69, 38.17 -87.91, 154.07 39.86, 88.52 -71.49, 59.19 out-out out 15.3138 Saltbr-out 14.9939 HRD-in -70.73, -50.42 71.08, -9.53 out-out-out SNCooo out-out ActLoopNT-out 8.9548 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -121.3 APE8-dihe-out -86.65, -7.6 APE8-rot-out 192.68 APE67-dihe-out -130.89, 138.61 -149.99, 133.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.6751 None None None XRAY 2.3 0.22 0.268 A 326.0 297.0 5 26 21 5 [[68, 361]] 1.0 7b3m Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B3MB Q02750 37 382 393.0 ANP:60402,SU5:60403 ATPlike,Type3 Inactive DFGin 6.095 13.3497 BLBplus -147.84, 168.76 59.95, 38.27 -86.94, 152.02 37.7, 89.9 -70.97, 59.7 out-out out 15.2643 Saltbr-out 14.844 HRD-in -70.51, -50.26 71.48, -11.7 out-out-out SNCooo out-out ActLoopNT-out 8.913 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -133.25 APE8-dihe-out -83.19, -28.76 APE8-rot-in 262.25 APE67-dihe-out -150.63, 137.62 -127.52, 158.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.0843 None None None XRAY 2.3 0.22 0.268 B 326.0 298.0 4 26 22 4 [[68, 361]] 1.0 7b3m Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B7RA Q02750 37 382 393.0 ANP:60401,T1K:60403 ATPlike,Type3 Inactive DFGin 6.1419 13.1685 BLBplus -135.79, 174.07 60.45, 39.3 -91.52, 155.87 43.71, 91.25 -77.25, 65.03 out-out out 15.2989 Saltbr-out 15.4643 HRD-in -68.45, -57.29 78.52, -6.73 out-out-out SNCooo out-out ActLoopNT-out 8.9351 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -104.92 APE8-dihe-out -68.21, -24.42 APE8-rot-out 184.14 APE67-dihe-out -122.45, 137.43 -138.43, 139.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.332 None None None XRAY 1.7 0.195 0.218 A 326.0 297.0 5 26 21 5 [[68, 361]] 1.0 7b7r Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B7RB Q02750 39 382 393.0 ANP:60401,T1K:60403 ATPlike,Type3 Inactive DFGin 6.0337 13.1313 BLBplus -135.72, 177.16 59.39, 36.14 -85.12, 154.58 37.29, 94.77 -80.68, 71.22 out-out out 15.2953 Saltbr-out 15.3776 HRD-in -70.94, -55.67 77.08, -4.68 out-out-out SNCooo out-out ActLoopNT-out 8.8997 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -49.75 APE8-rot-out 171.35 APE67-dihe-out -144.02, 141.19 -140.4, 157.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.195 0.218 B 326.0 295.0 5 26 21 5 [[68, 361]] 1.0 7b7r Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B94A Q02750 37 382 393.0 ANP:60401,T3W:60403 ATPlike,Type3 Inactive DFGin 5.9919 13.4781 BLBplus -132.63, 177.07 57.77, 37.37 -87.97, 156.39 42.38, 94.42 -75.9, 68.49 out-out out 15.5318 Saltbr-out 15.193 HRD-in -65.24, -55.1 71.13, -2.53 out-out-out SNCooo out-out ActLoopNT-out 8.8875 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 176.47 APE8-dihe-out -89.38, 6.07 APE8-rot-in 312.59 APE67-dihe-out -115.47, 140.44 -116.58, 113.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.5994 None None None XRAY 2.0 0.218 0.265 A 326.0 297.0 5 26 21 5 [[68, 361]] 1.0 7b94 Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B94B Q02750 41 382 393.0 ANP:60401,T3W:60403 ATPlike,Type3 Inactive DFGin 5.8527 13.5104 BLBplus -134.32, 175.36 55.61, 39.25 -86.46, 153.65 39.68, 92.62 -72.74, 66.29 out-out out 15.1174 Saltbr-out 14.5478 HRD-in -66.3, -53.58 77.63, -11.98 out-out-out SNCooo out-out ActLoopNT-out 8.6174 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -40.61 APE8-rot-out 185.17 APE67-dihe-out -147.87, 139.4 -127.59, 154.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.218 0.265 B 326.0 293.0 5 26 21 5 [[68, 361]] 1.0 7b94 Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B9LA Q02750 37 382 393.0 ANP:60401,T4N:60402 ATPlike,Type3 Inactive DFGin 6.1432 13.3849 BLBplus -137.56, 174.87 57.48, 45.06 -95.99, 156.93 43.03, 91.55 -78.34, 66.31 out-out out 15.2718 Saltbr-out 15.2434 HRD-in -67.86, -56.92 79.15, -7.52 out-out-none SNCoon out-none ActLoopNT-out 8.9677 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -119.38, 141.01 999.0, 135.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.194 0.214 A 326.0 295.0 7 26 19 7 [[68, 361]] 1.0 7b9l Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B9LB Q02750 41 381 393.0 ANP:60401,T4N:60402 ATPlike,Type3 Inactive DFGin 5.9579 13.456 BLBplus -136.66, 175.43 56.67, 43.08 -92.39, 158.5 42.85, 91.66 -74.84, 62.99 out-out out 15.1558 Saltbr-out 14.9359 HRD-in -69.72, -56.61 80.29, -8.28 out-out-none SNCoon out-none ActLoopNT-out 8.6924 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -146.85, 137.07 999.0, 132.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.194 0.214 B 326.0 291.0 6 26 20 6 [[68, 361]] 1.0 7b9l Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3ORNA Q02750 62 380 393.0 ANP:60001,3OR:60400 ATPlike,Type3 Inactive DFGin 6.0287 13.8039 BLBplus -141.26, -171.81 51.14, 43.91 -94.56, 165.92 40.22, 96.28 -82.7, 73.49 out-out out 15.3451 Saltbr-out 15.2454 HRD-in -75.72, -51.63 76.11, -2.33 out-out-out SNCooo out-out ActLoopNT-out 9.2477 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -90.01, 161.45 APE9-dihe-na 75.09, 172.06 APE8-dihe-out -101.08, -27.15 APE8-rot-out 71.34 APE67-dihe-out -133.03, 139.32 -108.61, 153.73 APE12-dist-out 16.856 APE11-dist-out 20.6225 APE10-dist-out 18.5661 APE9-dist-out 13.0454 None None None XRAY 2.8 0.236 0.277 A 307.0 279.0 8 26 26 0 [[68, 361]] 1.0 3orn Homo sapiens STE_MAP2K1_HUMAN STE 9.7e-99 335.8 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3WIGA Q02750 62 380 393.0 ANP:60401,CHU:60403 ATPlike,Type3 Inactive DFGin 6.2646 14.0156 BLBplus -143.18, 168.24 57.0, 43.27 -87.61, 167.58 35.17, 91.44 -81.11, 80.9 out-out out 15.2231 Saltbr-out 15.2345 HRD-in -81.12, -52.72 78.66, -9.66 out-out-out SNCooo out-out ActLoopNT-out 9.2519 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -106.56, 160.96 APE9-dihe-na 79.87, 168.49 APE8-dihe-out -95.77, -24.16 APE8-rot-out 58.57 APE67-dihe-out -134.06, 137.9 -112.83, 153.13 APE12-dist-out 16.5068 APE11-dist-out 20.1486 APE10-dist-out 18.5012 APE9-dist-out 12.9477 None None None XRAY 2.7 0.217 0.25 A 307.0 277.0 10 26 26 0 [[68, 361]] 1.0 3wig Homo sapiens STE_MAP2K1_HUMAN STE 9.7e-99 335.8 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4U80A Q02750 62 379 393.0 ANP:60501,3EX:60502 ATPlike,Type3 Inactive DFGin 6.1423 13.3581 BLBplus -137.92, -179.3 57.25, 41.8 -100.21, 164.46 49.55, 87.81 -82.1, 69.9 out-out out 15.3907 Saltbr-out 16.1744 HRD-in -63.5, -60.19 86.1, -12.96 out-out-out SNCooo out-out ActLoopNT-out 9.1744 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnoo APE10-dihe-na 999.0, -56.89 APE9-dihe-na 91.88, -152.59 APE8-dihe-out -126.68, 10.89 APE8-rot-in 310.84 APE67-dihe-out -98.05, 140.26 -155.43, 115.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.5568 APE9-dist-out 13.4268 None None None XRAY 2.8 0.167 0.224 A 341.0 285.0 33 26 23 3 [[68, 361]] 1.0 4u80 Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4LMNA Q02750 62 382 393.0 ANP:60501,EUI:60503 ATPlike,Type3 Inactive DFGin 6.1087 13.4073 BLBplus -150.33, -178.45 56.52, 30.25 -84.69, 155.37 45.37, 87.33 -80.58, 74.43 out-out out 15.5596 Saltbr-out 15.7763 HRD-in -60.71, -57.05 86.56, -12.8 out-out-out SNCooo out-out ActLoopNT-out 9.0127 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -106.36, -106.55 APE9-dihe-na -110.69, -4.9 APE8-dihe-out -94.39, -2.53 APE8-rot-out 38.79 APE67-dihe-out -120.37, 128.01 -144.86, 111.2 APE12-dist-out 20.4741 APE11-dist-out 19.7321 APE10-dist-out 22.049 APE9-dist-out 15.3113 None None None XRAY 2.8 0.193 0.233 A 341.0 291.0 30 26 26 0 [[68, 361]] 1.0 4lmn Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7UMBC Q02750 41 381 393.0 ANP:401,U9F:402 ATPlike,Type3 Inactive DFGin 6.169 13.7668 BLBplus -162.24, 171.11 70.21, 49.7 -113.95, 160.88 44.65, 94.08 -79.06, 81.13 out-out out 15.5589 Saltbr-out 15.2725 HRD-in -66.12, -48.09 76.83, -9.86 out-out-out SNCooo out-out ActLoopNT-out 9.5911 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -127.94, 139.36 APE9-dihe-na -138.86, -160.81 APE8-dihe-out -82.2, -18.64 APE8-rot-out 50.9 APE67-dihe-out -106.39, 139.13 -104.8, 110.61 APE12-dist-out 16.6992 APE11-dist-out 19.6656 APE10-dist-out 21.5701 APE9-dist-out 14.915 None None None XRAY 3.231 0.231 0.268 C 384.0 303.0 38 26 26 0 [[68, 361]] 1.0 7umb Homo sapiens STE_MAP2K1_HUMAN STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 6PP9B Q02750 38 383 393.0 ANP:801,LCJ:803 ATPlike,Type3 Inactive DFGin 6.0507 13.8503 BLBplus -152.52, 171.62 57.53, 41.01 -92.48, 164.33 45.1, 87.01 -81.4, 67.83 out-out out 15.4693 Saltbr-out 15.3255 HRD-in -69.19, -57.7 73.02, -1.06 out-out-out SNCooo out-out ActLoopNT-out 8.325 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -150.75, 155.46 APE9-dihe-na -104.35, -179.3 APE8-dihe-out -103.86, -21.71 APE8-rot-out 60.0 APE67-dihe-out -161.36, 138.21 -120.01, -175.99 APE12-dist-out 17.6293 APE11-dist-out 18.0984 APE10-dist-out 21.1907 APE9-dist-out 12.1845 S218A,S222A None None XRAY 2.59 0.222 0.245 B 397.0 314.0 32 26 26 0 [[68, 361]] 1.0 6pp9 Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0VB Q02750 42 383 393.0 ANP:801,EUI:803 ATPlike,Type3 Inactive DFGin 6.0381 13.7379 BLBplus -152.98, 176.74 51.89, 40.05 -97.58, 155.01 48.54, 94.68 -74.32, 76.65 out-out out 15.3562 Saltbr-out 15.2475 HRD-in -53.62, -41.23 79.48, -8.01 out-out-out SNCooo out-out ActLoopNT-out 8.4508 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -59.78, 136.18 APE9-dihe-na -90.07, -164.06 APE8-dihe-out -111.55, -13.91 APE8-rot-out 80.18 APE67-dihe-out -157.27, 123.12 -113.49, 175.2 APE12-dist-out 17.7535 APE11-dist-out 19.5873 APE10-dist-out 21.2162 APE9-dist-out 13.438 S218A,S222A None None XRAY 3.16 0.188 0.234 B 397.0 310.0 32 26 26 0 [[68, 361]] 1.0 7m0v Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0WB Q02750 42 383 393.0 ANP:801,QOA:803 ATPlike,Type3 Inactive DFGin 6.1482 14.0545 BLBplus -157.1, -177.15 57.47, 39.21 -94.37, 139.97 49.64, 89.26 -60.24, 75.28 out-out out 15.239 Saltbr-out 15.1806 HRD-in -60.24, -53.72 67.58, 4.61 out-out-out SNCooo out-out ActLoopNT-out 8.8656 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -57.72, 142.94 APE9-dihe-na -85.2, -169.93 APE8-dihe-out -102.45, -22.28 APE8-rot-out 37.77 APE67-dihe-out -129.82, 144.3 -151.67, 158.88 APE12-dist-out 17.5121 APE11-dist-out 22.6571 APE10-dist-out 23.4774 APE9-dist-out 13.5899 S218A,S222A None None XRAY 3.09 0.197 0.233 B 397.0 310.0 32 26 26 0 [[68, 361]] 1.0 7m0w Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0XB Q02750 40 383 393.0 ANP:801,4BM:803 ATPlike,Type3 Inactive DFGin 6.0399 13.7075 BLBplus -145.13, 173.52 62.48, 32.29 -85.3, 166.26 43.84, 89.91 -82.62, 63.8 out-out out 15.2193 Saltbr-out 15.1277 HRD-in -57.93, -57.46 71.94, -0.74 out-out-out SNCooo out-out ActLoopNT-out 8.3308 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -140.02, 147.44 APE9-dihe-na -87.47, -179.23 APE8-dihe-out -111.82, -15.11 APE8-rot-out 56.07 APE67-dihe-out -151.04, 140.91 -141.23, 175.81 APE12-dist-out 17.7952 APE11-dist-out 17.9191 APE10-dist-out 21.3926 APE9-dist-out 11.9857 S218A,S222A None None XRAY 2.47 0.18 0.215 B 397.0 312.0 32 26 26 0 [[68, 361]] 1.0 7m0x Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0YB Q02750 43 382 393.0 ANP:401,QOM:404 ATPlike,Type3 Inactive DFGin 5.9314 13.9674 BLBplus -158.94, 162.56 56.25, 36.06 -89.69, 147.0 54.27, 82.92 -67.13, 108.1 out-out out 15.4927 Saltbr-out 15.9617 HRD-in -58.74, -61.39 74.04, 6.51 out-out-out SNCooo out-out ActLoopNT-out 9.4018 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -63.76, 140.76 APE9-dihe-na -82.11, -165.89 APE8-dihe-out -109.48, -23.44 APE8-rot-out 48.75 APE67-dihe-out -133.69, 134.38 -151.5, 158.4 APE12-dist-out 17.3805 APE11-dist-out 22.4528 APE10-dist-out 23.379 APE9-dist-out 13.66 S218A,S222A None None XRAY 3.45 0.196 0.218 B 397.0 308.0 32 26 26 0 [[68, 361]] 1.0 7m0y Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0ZB Q02750 42 383 393.0 ANP:401,CHU:402 ATPlike,Type3 Inactive DFGin 6.1064 14.1069 BLBplus -160.77, 175.85 59.87, 41.63 -97.41, 152.84 45.88, 80.73 -66.99, 92.55 out-out out 15.4927 Saltbr-out 15.371 HRD-in -96.91, -40.79 69.65, -8.88 out-out-out SNCooo out-out ActLoopNT-out 9.612 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -66.4, 138.99 APE9-dihe-na -84.75, -165.15 APE8-dihe-out -106.74, -38.37 APE8-rot-out 38.19 APE67-dihe-out -129.38, 138.55 -136.73, 157.33 APE12-dist-out 17.2133 APE11-dist-out 22.3822 APE10-dist-out 23.6126 APE9-dist-out 13.6034 S218A,S222A None None XRAY 3.12 0.193 0.225 B 397.0 310.0 32 26 26 0 [[68, 361]] 1.0 7m0z Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXHA Q02750 39 381 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.113 14.2053 BLBplus -138.52, 176.84 56.32, 45.26 -98.43, 166.79 48.45, 76.71 -79.29, 73.17 out-out out 15.3891 Saltbr-out 15.4608 HRD-in -79.27, -55.22 75.38, 2.3 out-out-out SNCooo out-out ActLoopNT-out 9.3908 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -141.27, 126.74 APE9-dihe-na -91.23, -150.48 APE8-dihe-out -108.84, -16.83 APE8-rot-out 178.7 APE67-dihe-out -130.79, 128.8 -115.86, 151.78 APE12-dist-out 17.4166 APE11-dist-out 17.6237 APE10-dist-out 20.8985 APE9-dist-out 13.1543 None None None XRAY 2.81 0.206 0.253 A 310.0 299.0 0 26 26 0 [[68, 361]] 1.0 9axh Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-98 335.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXHB Q02750 38 381 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.0283 13.959 BLBplus -143.4, 172.79 59.61, 49.11 -104.03, 163.1 47.48, 79.51 -74.37, 70.81 out-out out 15.4154 Saltbr-out 14.8168 HRD-in -76.49, -58.47 81.39, -4.23 out-out-out SNCooo out-out ActLoopNT-out 9.3218 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -140.95, 129.53 APE9-dihe-na -95.7, -172.17 APE8-dihe-out -83.87, -23.26 APE8-rot-out 67.32 APE67-dihe-out -134.03, 129.22 -119.03, 156.34 APE12-dist-out 17.3071 APE11-dist-out 17.5745 APE10-dist-out 20.8998 APE9-dist-out 12.718 None None None XRAY 2.81 0.206 0.253 B 310.0 300.0 0 26 26 0 [[68, 361]] 1.0 9axh Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-98 335.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXMA Q02750 38 382 393.0 A1AHE:60401,ANP:60403 Type1,ATPlike Inactive DFGin 6.2039 13.9992 BLBplus -146.84, 170.95 57.84, 58.3 -113.46, 158.4 47.1, 81.42 -71.93, 78.64 out-out out 15.4263 Saltbr-out 15.5133 HRD-in -80.25, -54.29 71.05, 3.5 out-out-out SNCooo out-out ActLoopNT-out 9.1102 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -58.81, 135.38 APE9-dihe-na -86.44, -174.93 APE8-dihe-out -114.7, -19.48 APE8-rot-out 61.33 APE67-dihe-out -156.42, 133.96 -137.25, 175.14 APE12-dist-out 17.3471 APE11-dist-out 22.1228 APE10-dist-out 24.2234 APE9-dist-out 13.2409 S218A,S222A None None XRAY 2.42 0.263 0.301 A 310.0 301.0 0 26 26 0 [[68, 361]] 1.0 9axm Homo sapiens STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXXA Q02750 41 382 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.1565 14.4729 BLBplus -142.21, 167.57 61.94, 40.19 -92.82, 170.58 38.95, 89.02 -82.21, 74.48 out-out out 15.9248 Saltbr-out 15.6608 HRD-in -77.34, -56.94 85.02, -11.71 out-out-out SNCooo out-out ActLoopNT-out 9.6225 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -70.01, 140.02 APE9-dihe-na -107.63, 178.58 APE8-dihe-out -103.64, -13.88 APE8-rot-out 56.98 APE67-dihe-out -152.18, 145.48 -132.34, 175.09 APE12-dist-out 18.633 APE11-dist-out 16.0857 APE10-dist-out 21.091 APE9-dist-out 12.7711 S218A,S222A None None XRAY 2.07 0.215 0.248 A 310.0 298.0 0 26 26 0 [[68, 361]] 1.0 9axx Homo sapiens STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXXC Q02750 37 378 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.0661 14.2508 BLBplus -153.34, 165.37 62.85, 41.08 -93.54, 164.6 44.67, 86.41 -75.31, 71.49 out-out out 15.5167 Saltbr-out 15.0221 HRD-in -80.68, -38.87 53.15, 7.3 out-out-out SNCooo out-out ActLoopNT-out 9.6912 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -68.91, 127.09 APE9-dihe-na -100.27, 169.31 APE8-dihe-out -98.12, -23.61 APE8-rot-out 61.42 APE67-dihe-out -153.77, 146.66 -125.41, 178.29 APE12-dist-out 18.4501 APE11-dist-out 16.1193 APE10-dist-out 21.5812 APE9-dist-out 12.7488 S218A,S222A None None XRAY 2.07 0.215 0.248 C 310.0 297.0 1 26 26 0 [[68, 361]] 1.0 9axx Homo sapiens STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AYAB Q02750 42 382 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.2091 14.117 BLBplus -156.4, 169.03 57.59, 47.08 -100.39, 159.82 46.95, 83.0 -73.48, 80.99 out-out out 15.4442 Saltbr-out 14.9574 HRD-in -72.22, -50.64 78.5, -7.92 out-out-out SNCooo out-out ActLoopNT-out 9.725 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -67.32, 133.53 APE9-dihe-na -94.07, -169.54 APE8-dihe-out -110.54, -56.8 APE8-rot-out 71.18 APE67-dihe-out -155.6, 139.89 -98.61, 175.74 APE12-dist-out 17.2211 APE11-dist-out 22.1488 APE10-dist-out 24.1945 APE9-dist-out 13.7662 S218A,S222A None None XRAY 2.59 0.214 0.257 B 310.0 297.0 0 26 26 0 [[68, 361]] 1.0 9aya Homo sapiens STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AYAD Q02750 39 382 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.236 14.1136 BLBplus -150.42, 169.48 62.14, 35.37 -84.74, 166.85 39.42, 88.37 -83.08, 73.44 out-out out 15.3824 Saltbr-out 15.2874 HRD-in -84.82, -56.5 86.5, -11.08 out-out-out SNCooo out-out ActLoopNT-out 9.653 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 132.69 APE8-dihe-out -103.38, -24.48 APE8-rot-out 47.89 APE67-dihe-out -161.23, 135.82 -100.94, -174.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.7487 S218A,S222A None None XRAY 2.59 0.214 0.257 D 310.0 293.0 7 26 23 3 [[68, 361]] 1.0 9aya Homo sapiens STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AY7B Q02750 33 383 393.0 A1AHE:401,ANP:402 Type1,ATPlike Inactive DFGin 6.1312 14.2675 BLBplus -154.96, 169.08 61.0, 36.72 -91.6, 162.02 49.73, 81.71 -77.61, 77.19 out-out out 15.5132 Saltbr-out 15.4022 HRD-in -75.89, -55.94 83.29, -11.88 out-out-out SNCooo out-out ActLoopNT-out 9.5756 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -66.62, 136.57 APE9-dihe-na -89.93, -175.43 APE8-dihe-out -113.57, -10.62 APE8-rot-out 51.26 APE67-dihe-out -146.5, 144.85 -157.42, 170.13 APE12-dist-out 17.3436 APE11-dist-out 22.1142 APE10-dist-out 24.2068 APE9-dist-out 13.7295 S218A,S222A None None XRAY 2.41 0.203 0.236 B 394.0 322.0 29 26 26 0 [[68, 361]] 1.0 9ay7 Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0UH Q02750 30 380 393.0 CHU:401,ANP:402 Type1,ATPlike Inactive DFGin 6.2263 14.2396 BLBplus -153.68, 170.44 61.41, 47.24 -102.95, 164.39 45.69, 94.01 -79.55, 83.41 out-out out 15.5809 Saltbr-out 15.7853 HRD-in -74.86, -48.68 73.9, -6.25 out-out-out SNCooo out-out ActLoopNT-out 9.583 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -141.84, 152.52 APE9-dihe-na -130.16, 177.33 APE8-dihe-out -105.34, -25.09 APE8-rot-out 37.73 APE67-dihe-out -147.39, 136.35 -136.55, 176.51 APE12-dist-out 17.387 APE11-dist-out 17.659 APE10-dist-out 22.2151 APE9-dist-out 12.9967 S218A,S222A None None XRAY 2.91 0.232 0.264 H 395.0 315.0 36 26 26 0 [[68, 361]] 1.0 9o0u Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0VB Q02750 30 380 393.0 CHU:401,ANP:402 Type1,ATPlike Inactive DFGin 6.1927 14.1253 BLBplus -151.85, 167.5 59.4, 48.24 -102.03, 163.4 46.52, 86.88 -79.89, 84.21 out-out out 15.5955 Saltbr-out 16.8415 HRD-in -72.2, -48.2 74.46, -6.51 out-out-out SNCooo out-out ActLoopNT-out 9.7061 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -135.59, 156.7 APE9-dihe-na -122.67, 146.4 APE8-dihe-out -101.77, -26.6 APE8-rot-in 280.72 APE67-dihe-out -147.98, 135.29 -136.69, 175.09 APE12-dist-out 16.923 APE11-dist-out 17.129 APE10-dist-out 21.8624 APE9-dist-out 12.4292 S218A,S222A None None XRAY 3.5 0.208 0.254 B 395.0 322.0 29 26 26 0 [[68, 361]] 1.0 9o0v Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0VH Q02750 30 380 393.0 CHU:401,ANP:402 Type1,ATPlike Inactive DFGin 6.3491 14.2266 BLBplus -152.81, 169.25 61.22, 47.15 -103.13, 164.19 45.91, 94.17 -79.63, 83.31 out-out out 15.6315 Saltbr-out 15.9163 HRD-in -74.73, -48.72 73.54, -6.07 out-out-out SNCooo out-out ActLoopNT-out 9.5069 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -142.21, 151.98 APE9-dihe-na -130.61, 176.34 APE8-dihe-out -105.52, -25.24 APE8-rot-out 37.89 APE67-dihe-out -147.93, 136.16 -136.73, 176.12 APE12-dist-out 17.2775 APE11-dist-out 17.5835 APE10-dist-out 22.1521 APE9-dist-out 13.0006 S218A,S222A None None XRAY 3.5 0.208 0.254 H 395.0 318.0 33 26 26 0 [[68, 361]] 1.0 9o0v Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4U7ZA Q02750 62 382 393.0 3EW:60502,ANP:60503 Type3,ATPlike Inactive DFGin 6.2159 13.6689 BLBplus -143.34, -175.79 52.44, 38.8 -93.27, 161.31 44.21, 87.69 -81.82, 73.69 out-out out 15.3339 Saltbr-out 16.1402 HRD-in -66.47, -61.07 88.23, -17.21 out-out-out SNCooo out-out ActLoopNT-out 9.1989 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_onoo APE10-dihe-na 999.0, -56.79 APE9-dihe-na 112.87, -133.38 APE8-dihe-out -132.3, 18.52 APE8-rot-out 53.52 APE67-dihe-out -108.34, 133.35 -145.71, 114.06 APE12-dist-out 17.9335 APE11-dist-none 999.0 APE10-dist-out 19.6013 APE9-dist-out 13.9529 None None None XRAY 2.805 0.163 0.214 A 341.0 290.0 31 26 25 1 [[68, 361]] 1.0 4u7z Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4U81A Q02750 62 382 393.0 3EY:60502,ANP:60503 Type3,ATPlike Inactive DFGin 6.3677 13.5745 BLBplus -142.15, -179.17 57.69, 35.98 -93.9, 164.88 44.15, 86.95 -87.34, 72.9 out-out out 15.2755 Saltbr-out 15.4161 HRD-in -63.27, -55.06 80.23, -11.72 out-out-out SNCooo out-out ActLoopNT-out 9.3239 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -28.47 APE9-dihe-na 110.81, -177.13 APE8-dihe-out -114.66, 19.88 APE8-rot-out 189.5 APE67-dihe-out -109.38, 142.31 -159.49, 131.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.6841 APE9-dist-out 12.9691 None None None XRAY 2.701 0.169 0.218 A 341.0 288.0 33 26 23 3 [[68, 361]] 1.0 4u81 Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9ECUB Q02750 43 383 393.0 A1BIS:401,ANP:402 Type3,ATPlike Inactive DFGin 5.9391 13.7784 BLBplus -142.06, 162.17 53.85, 47.21 -95.43, 152.31 51.94, 84.92 -79.97, 96.68 out-out out 15.5116 Saltbr-out 16.1296 HRD-in -66.75, -57.05 86.44, -9.92 out-out-out SNCooo out-out ActLoopNT-out 9.377 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -121.25, 157.88 APE9-dihe-na -135.0, 168.26 APE8-dihe-out -68.75, -42.35 APE8-rot-in 291.8 APE67-dihe-out -146.65, 140.6 -150.67, 174.43 APE12-dist-out 21.121 APE11-dist-out 17.8937 APE10-dist-out 23.1346 APE9-dist-out 13.6562 None None None XRAY 3.46 0.202 0.237 B 393.0 309.0 32 26 26 0 [[68, 361]] 1.0 9ecu Homo sapiens STE_MAP2K1_HUMAN STE 2.4e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXYB Q02750 40 383 393.0 A1AHE:401,ANP:402 Type3,ATPlike Inactive DFGin 5.9383 14.1345 BLBplus -149.11, 165.49 51.9, 40.29 -92.3, 159.5 54.58, 76.32 -75.9, 70.87 out-out out 15.3992 Saltbr-out 14.9875 HRD-in -57.0, -47.47 79.88, -10.87 out-out-out SNCooo out-out ActLoopNT-out 9.3372 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -115.09, 128.49 APE9-dihe-na -79.18, 173.05 APE8-dihe-out -111.11, -19.81 APE8-rot-out 47.95 APE67-dihe-out -148.5, 141.81 -130.51, 175.5 APE12-dist-out 18.1758 APE11-dist-out 19.7311 APE10-dist-out 22.7854 APE9-dist-out 13.2287 S218A,S222A None None XRAY 3.6 0.19 0.237 B 394.0 312.0 32 26 26 0 [[68, 361]] 1.0 9axy Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0VD Q02750 31 380 393.0 CHU:401,ANP:402 Type3,ATPlike Inactive DFGin 6.3733 14.325 BLBplus -154.54, 169.16 62.18, 48.49 -103.44, 163.24 44.6, 81.5 -80.27, 83.26 out-out out 16.0835 Saltbr-out 14.6053 HRD-in -72.92, -47.49 72.01, -5.54 out-out-out SNCooo out-out ActLoopNT-out 9.4975 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -145.24, 151.58 APE9-dihe-na -129.14, 150.7 APE8-dihe-out -101.27, -25.48 APE8-rot-in 295.39 APE67-dihe-out -149.5, 133.8 -134.87, 174.51 APE12-dist-out 17.6813 APE11-dist-out 17.5865 APE10-dist-out 22.6132 APE9-dist-out 12.7344 S218A,S222A None None XRAY 3.5 0.208 0.254 D 395.0 315.0 35 26 26 0 [[68, 361]] 1.0 9o0v Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0VF Q02750 30 380 393.0 CHU:401,ANP:402 Type3,ATPlike Inactive DFGin 6.3482 14.2973 BLBplus -150.02, 162.92 66.4, 48.22 -102.89, 163.79 46.62, 89.05 -79.32, 84.9 out-out out 15.5104 Saltbr-out 15.8816 HRD-in -75.24, -46.98 72.8, -6.4 out-out-out SNCooo out-out ActLoopNT-out 9.801 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -127.4, 126.99 APE9-dihe-na -155.92, 117.08 APE8-dihe-out -98.23, -9.95 APE8-rot-in 320.72 APE67-dihe-out -148.49, 134.6 -133.67, 172.28 APE12-dist-out 18.6736 APE11-dist-out 16.7401 APE10-dist-out 21.3436 APE9-dist-out 12.7026 S218A,S222A None None XRAY 3.5 0.208 0.254 F 395.0 322.0 29 26 26 0 [[68, 361]] 1.0 9o0v Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0TB Q02750 42 383 393.0 3EW:401,ANP:402 Type3,ATPlike Inactive DFGin 6.0753 13.7095 BLBplus -159.9, -178.5 64.02, 41.63 -104.3, 143.17 46.34, 100.82 -64.54, 70.24 out-out out 15.4777 Saltbr-out 16.3323 HRD-in -53.73, -55.69 69.68, 5.22 out-out-out SNCooo out-out ActLoopNT-out 8.8715 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -40.91, 141.26 APE9-dihe-na -101.18, -177.28 APE8-dihe-out -68.44, -50.32 APE8-rot-in 321.79 APE67-dihe-out -148.38, 132.66 -145.97, 175.15 APE12-dist-out 17.1657 APE11-dist-out 22.6476 APE10-dist-out 23.7095 APE9-dist-out 13.8641 S218A,S222A None None XRAY 3.19 0.199 0.254 B 397.0 310.0 32 26 26 0 [[68, 361]] 1.0 7m0t Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0UB Q02750 43 385 393.0 QO7:501,ANP:502 Type3,ATPlike Inactive DFGin 6.1782 13.8403 BLBplus -152.87, -177.82 54.02, 43.66 -96.33, 148.45 42.9, 86.91 -71.94, 82.66 out-out out 15.4928 Saltbr-out 15.6637 HRD-in -60.41, -57.85 71.46, -3.21 out-out-out SNCooo out-out ActLoopNT-out 9.0481 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -60.78, 138.09 APE9-dihe-na -86.76, -175.69 APE8-dihe-out -100.26, -15.57 APE8-rot-out 49.06 APE67-dihe-out -118.78, 147.11 -163.65, 150.46 APE12-dist-out 17.2011 APE11-dist-out 22.3588 APE10-dist-out 23.5662 APE9-dist-out 13.6379 S218A,S222A None None XRAY 3.09 0.193 0.23 B 397.0 311.0 32 26 26 0 [[68, 361]] 1.0 7m0u Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 5YT3B Q02750 40 382 393.0 ANP:401 ATPlike Inactive DFGin 5.8963 14.534 None -102.15, -169.78 -40.15, 149.52 -75.91, 143.56 303.08, 84.8 -64.88, 94.03 out-out out 16.3586 Saltbr-out 14.8656 HRD-out -104.42, 23.77 -144.46, 111.13 out-out-out SNCooo out-out ActLoopNT-out 8.0209 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -80.58, -32.09 APE9-dihe-na -86.11, -15.83 APE8-dihe-out 58.15, 64.44 APE8-rot-in 310.76 APE67-dihe-out -122.56, 143.11 -138.66, 139.98 APE12-dist-out 19.0552 APE11-dist-out 14.0554 APE10-dist-out 18.8403 APE9-dist-out 25.9099 S218D,S222D,T292A,S298A None None XRAY 2.9 0.213 0.289 B 350.0 311.0 32 26 26 0 [[68, 361]] 1.0 5yt3 Homo sapiens STE_MAP2K1_HUMAN STE 4.7e-97 330.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 5YT3D Q02750 39 382 393.0 ANP:401 ATPlike Inactive DFGin 5.7501 14.7176 None -77.53, 172.31 -71.81, 159.92 -66.82, 141.72 314.31, 87.77 -59.96, 135.61 out-out out 16.8715 Saltbr-out 15.0058 HRD-out -106.97, -11.01 -97.02, 107.72 out-out-out SNCooo out-out ActLoopNT-out 8.2442 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -63.82, -51.0 APE9-dihe-na -70.37, -13.35 APE8-dihe-out 47.35, 74.88 APE8-rot-out 143.99 APE67-dihe-out -134.73, 126.26 -143.64, 140.67 APE12-dist-out 19.3394 APE11-dist-out 14.3822 APE10-dist-out 19.1547 APE9-dist-out 26.1684 S218D,S222D,T292A,S298A None None XRAY 2.9 0.213 0.289 D 350.0 309.0 35 26 26 0 [[68, 361]] 1.0 5yt3 Homo sapiens STE_MAP2K1_HUMAN STE 4.7e-97 330.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 5YT3A Q02750 39 382 393.0 ANP:401 ATPlike Inactive DFGinter 6.3567 10.3827 None -128.68, 173.26 63.68, 38.66 -52.93, -21.76 28.6, 36.22 -61.84, 114.84 out-out out 16.3153 Saltbr-out 14.589 HRD-in -77.7, -42.23 58.41, 13.61 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 70.97 APE8-rot-none 999.0 APE67-dihe-out -132.4, 139.8 -149.07, 91.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S218D,S222D,T292A,S298A None None XRAY 2.9 0.213 0.289 A 350.0 297.0 47 26 12 14 [[68, 361]] 1.0 5yt3 Homo sapiens STE_MAP2K1_HUMAN STE 4.7e-97 330.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7F2XA Q02750 45 382 393.0 ANP:60501 ATPlike Inactive None 14.5783 16.4961 None -71.03, 160.3 -74.32, 105.83 -69.14, -7.13 285.96, 1.01 -79.69, -8.9 out-out out 16.3606 Saltbr-out 16.8732 HRD-out -123.25, -2.01 -136.26, 151.99 out-out-out SNCooo out-out ActLoopNT-out 10.3746 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -84.56, -47.24 APE9-dihe-na 151.04, 109.57 APE8-dihe-in -68.48, 129.23 APE8-rot-in 304.12 APE67-dihe-out -103.66, 129.16 -127.47, 104.31 APE12-dist-out 14.4563 APE11-dist-out 17.6728 APE10-dist-out 20.3077 APE9-dist-out 25.5229 None None None XRAY 2.007 0.216 0.232 A 321.0 300.0 0 26 26 0 [[68, 361]] 1.0 7f2x Homo sapiens STE_MAP2K1_HUMAN STE 1.4e-97 332.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K4 MP2K4_HUMAN 3ALNA P45985 83 389 399.0 ANP:1 ATPlike Inactive DFGin 6.5172 13.3925 BLBplus -161.78, 169.91 72.82, 15.08 -92.63, 122.04 60.81, 71.89 121.07, -111.8 out-na out 15.5254 Saltbr-na 999.0 HRD-in -50.15, -58.45 86.79, 0.09 na-out-none SNCaon out-none ActLoopNT-out 11.0944 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.289 0.378 A 327.0 270.0 37 27 7 20 [[102, 367]] 1.0 3aln Homo sapiens STE_MAP2K4_HUMAN STE 6.8e-86 293.8 4.0 257.0 254.0 246 247 248 250 252 131 148 152 226 228 227 229.0 289 273 268 267 266 265 264 263 262 179 Dual specificity mitogen-activated protein kinase kinase 4
STE MAP2K4 MP2K4_HUMAN 3ALNB P45985 84 390 399.0 ANP:1 ATPlike Inactive DFGin 7.0625 13.6128 BLBplus -140.58, 160.03 87.63, 22.27 -95.55, 159.55 58.77, 88.3 94.56, -147.05 out-na out 15.2673 Saltbr-na 14.9486 HRD-in -87.89, -53.1 65.57, 1.61 na-out-none SNCaon out-none ActLoopNT-out 8.2553 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.289 0.378 B 327.0 263.0 44 27 8 19 [[102, 367]] 1.0 3aln Homo sapiens STE_MAP2K4_HUMAN STE 6.8e-86 293.8 4.0 257.0 254.0 246 247 248 250 252 131 148 152 226 228 227 229.0 289 273 268 267 266 265 264 263 262 179 Dual specificity mitogen-activated protein kinase kinase 4
STE MAP2K4 MP2K4_HUMAN 3ALOA P45985 95 389 399.0 ANP:406 ATPlike Inactive DFGin 6.8866 13.7295 BLBplus -112.59, -177.7 66.85, 21.6 -92.73, 167.28 50.76, 92.54 73.18, -126.21 out-na out 15.8896 Saltbr-na 16.4758 HRD-in -52.75, -64.74 82.96, 2.2 na-out-out SNCaoo out-out ActLoopNT-out 8.2573 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na -57.34, 98.51 APE9-dihe-na 135.89, -16.86 APE8-dihe-out -126.39, -33.94 APE8-rot-na 70.02 APE67-dihe-out -48.7, -17.03 -94.49, 137.34 APE12-dist-out 18.4542 APE11-dist-out 19.5165 APE10-dist-out 20.4949 APE9-dist-out 23.0257 None None None XRAY 2.6 0.209 0.271 A 327.0 289.0 6 27 27 0 [[102, 367]] 1.0 3alo Homo sapiens STE_MAP2K4_HUMAN STE 6.8e-86 293.8 4.0 257.0 254.0 246 247 248 250 252 131 148 152 226 228 227 229.0 289 273 268 267 266 265 264 263 262 179 Dual specificity mitogen-activated protein kinase kinase 4
STE MAP2K4 MP2K4_HUMAN 3ALNC P45985 100 390 399.0 ANP:1 ATPlike Inactive None 999.0 11.66 None -139.2, 85.12 54.71, 167.37 -67.61, 999.0 74.38, 108.84 999.0, 999.0 none-na none 999.0 Saltbr-na 999.0 HRD-none 999.0, 999.0 999.0, 999.0 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.289 0.378 C 327.0 183.0 108 27 2 25 [[102, 367]] 1.0 3aln Homo sapiens STE_MAP2K4_HUMAN STE 6.8e-86 293.8 4.0 257.0 254.0 246 247 248 250 252 131 148 152 226 228 227 229.0 289 273 268 267 266 265 264 263 262 179 Dual specificity mitogen-activated protein kinase kinase 4
STE MAP4K1 M4K1_HUMAN 6CQDA Q92918 2 293 833.0 ANP:60301 ATPlike Inactive DFGin 6.0316 13.8855 BLAminus -140.97, 178.85 65.6, 83.06 -106.07, 25.72 286.0, 93.85 -58.74, -52.87 in-in in 8.5882 Saltbr-in 2.603 HRD-in -75.86, -49.25 70.86, -6.64 in-out-out SNCioo out-out ActLoopNT-out 5.6118 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -107.43, -47.34 APE9-dihe-na -128.13, -155.64 APE8-dihe-in -106.29, 135.18 APE8-rot-out 173.28 APE67-dihe-in -57.05, -28.95 -70.03, -34.9 APE12-dist-out 19.7103 APE11-dist-out 23.5071 APE10-dist-out 22.0831 APE9-dist-out 27.3122 None None None XRAY 2.12 0.206 0.25 A 297.0 288.0 4 28 28 0 [[17, 274]] 1.0 6cqd Homo sapiens STE_MAP4K1_HUMAN STE 4.2e-92 314.0 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6CQDB Q92918 4 293 833.0 ANP:60302 ATPlike Inactive DFGin 6.1011 14.2293 BLAminus -144.26, -175.8 58.68, 77.54 -93.97, 33.74 292.79, 90.96 -66.13, -50.88 in-in in 9.463 Saltbr-in 3.2089 HRD-in -76.3, -46.87 66.26, 5.48 in-out-out SNCioo out-out ActLoopNT-out 6.073 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -81.26, 126.5 APE9-dihe-na -81.79, -144.73 APE8-dihe-in -66.65, 145.16 APE8-rot-out 188.81 APE67-dihe-in -66.31, -22.65 -105.18, -2.62 APE12-dist-out 20.7631 APE11-dist-out 21.9588 APE10-dist-out 21.4095 APE9-dist-out 27.357 None None None XRAY 2.12 0.206 0.25 B 297.0 290.0 0 28 28 0 [[17, 274]] 1.0 6cqd Homo sapiens STE_MAP4K1_HUMAN STE 4.2e-92 314.0 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K4 M4K4_HUMAN 4U40A O95819 17 311 1239.0 ANP:401 ATPlike Inactive DFGin 3.8374 14.3902 BLBplus -136.79, 156.81 66.63, 45.06 -75.84, 145.72 56.03, 93.39 -61.09, 117.37 out-out out 11.6402 Saltbr-out 10.4893 HRD-in -68.35, -49.63 65.89, 2.04 out-out-out SNCooo out-out ActLoopNT-out 9.6283 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -76.11, -36.45 APE9-dihe-na 89.46, 175.41 APE8-dihe-in -63.67, 133.35 APE8-rot-out 188.73 APE67-dihe-in -61.71, -22.93 -96.09, -7.57 APE12-dist-out 14.8768 APE11-dist-out 14.965 APE10-dist-out 15.9776 APE9-dist-out 9.4768 None None None XRAY 2.3 0.201 0.262 A 332.0 295.0 0 28 28 0 [[25, 289]] 1.0 4u40 Homo sapiens STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
STE OXSR1 OXSR1_HUMAN 3DAKA O95747 6 295 527.0 ANP:1 ATPlike Inactive DFGin 5.1294 16.1767 BLBtrans -100.04, 163.42 76.18, 16.7 -60.44, 136.33 171.32, 70.03 96.86, -127.31 out-out out 12.5845 Saltbr-out 12.035 HRD-in -76.04, -45.57 81.12, -26.2 out-out-out SNCooo out-out ActLoopNT-out 8.169 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -91.06 APE9-dihe-na 161.92, -137.1 APE8-dihe-in -95.05, 112.91 APE8-rot-in 254.7 APE67-dihe-in -56.68, -24.99 -85.34, 38.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 29.3838 APE9-dist-out 30.0509 None None None XRAY 2.25 0.199 0.267 A 290.0 279.0 11 33 22 11 [[17, 291]] 1.0 3dak Homo sapiens STE_OXSR1_HUMAN STE 6e-94 320.1 1.0 257.0 257.0 163 164 165 167 169 46 63 67 143 145 144 146.0 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 3DAKB O95747 6 295 527.0 ANP:1 ATPlike Inactive DFGin 5.3319 16.237 BLBtrans -104.22, 159.58 79.05, 11.08 -51.8, 136.57 175.99, 64.12 96.31, -131.54 out-out out 12.4558 Saltbr-out 12.0827 HRD-in -78.09, -47.02 83.9, -24.13 out-out-none SNCoon out-none ActLoopNT-out 8.147 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 130.99 APE8-rot-in 294.38 APE67-dihe-in -53.25, -31.09 -85.79, 34.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.25 0.199 0.267 B 290.0 278.0 12 33 21 12 [[17, 291]] 1.0 3dak Homo sapiens STE_OXSR1_HUMAN STE 6e-94 320.1 1.0 257.0 257.0 163 164 165 167 169 46 63 67 143 145 144 146.0 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 3DAKC O95747 7 295 527.0 ANP:1 ATPlike Inactive DFGin 5.2 16.258 BLBtrans -99.19, 165.37 77.39, 13.36 -54.55, 139.89 174.92, 66.03 90.2, -129.87 out-out out 12.7953 Saltbr-out 12.192 HRD-in -79.55, -55.89 92.02, -15.23 out-out-out SNCooo out-out ActLoopNT-out 8.0721 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -81.49, 148.28 APE9-dihe-na 113.95, 160.67 APE8-dihe-in -84.39, 122.06 APE8-rot-out 195.33 APE67-dihe-in -62.35, -26.54 -78.99, 38.41 APE12-dist-out 26.3253 APE11-dist-out 28.8507 APE10-dist-out 33.354 APE9-dist-out 31.6785 None None None XRAY 2.25 0.199 0.267 C 290.0 281.0 8 33 25 8 [[17, 291]] 1.0 3dak Homo sapiens STE_OXSR1_HUMAN STE 6e-94 320.1 1.0 257.0 257.0 163 164 165 167 169 46 63 67 143 145 144 146.0 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 3DAKD O95747 7 295 527.0 ANP:1 ATPlike Inactive DFGin 5.5213 16.5996 BLBtrans -91.03, 168.13 66.29, 18.87 -59.74, 133.08 178.71, 62.0 94.13, -120.8 out-out out 12.7384 Saltbr-out 12.0313 HRD-in -82.87, -52.16 83.38, -16.35 out-out-out SNCooo out-out ActLoopNT-out 8.2495 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -78.42, 169.6 APE9-dihe-na 94.12, 158.49 APE8-dihe-in -86.45, 138.34 APE8-rot-out 182.04 APE67-dihe-in -59.03, -28.5 -85.94, 35.36 APE12-dist-none 999.0 APE11-dist-out 29.8075 APE10-dist-out 33.4887 APE9-dist-out 31.9154 None None None XRAY 2.25 0.199 0.267 D 290.0 284.0 5 33 28 5 [[17, 291]] 1.0 3dak Homo sapiens STE_OXSR1_HUMAN STE 6e-94 320.1 1.0 257.0 257.0 163 164 165 167 169 46 63 67 143 145 144 146.0 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 2VWIB O95747 9 292 527.0 ANP:1295 ATPlike Inactive DFGin 5.287 16.4266 BLBtrans -100.18, 160.58 80.18, 12.17 -59.65, 137.68 171.88, 72.09 96.85, -127.69 out-out out 12.997 Saltbr-out 12.2057 HRD-in -71.44, -47.93 86.11, -20.42 out-out-none SNCoon out-none ActLoopNT-out 7.9668 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 75.95 APE8-rot-in 320.74 APE67-dihe-in -62.37, -32.44 -100.52, 20.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.15 0.253 0.287 B 303.0 264.0 20 33 21 12 [[17, 291]] 1.0 2vwi Homo sapiens STE_OXSR1_HUMAN STE 7.1e-94 319.8 1.0 257.0 257.0 163 164 165 167 169 46 63 67 143 145 144 146.0 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 2VWIC O95747 9 292 527.0 ANP:1294 ATPlike Inactive DFGin 5.3005 16.2283 BLBtrans -96.83, 164.86 72.67, 17.81 -61.87, 137.0 171.22, 69.43 96.65, -124.96 out-out out 12.8178 Saltbr-out 12.4351 HRD-in -77.27, -48.25 84.09, -19.76 out-out-out SNCooo out-out ActLoopNT-out 7.9777 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 143.21 APE9-dihe-na 99.05, -143.58 APE8-dihe-in -115.19, 90.11 APE8-rot-out 49.11 APE67-dihe-in -67.35, -20.96 -80.96, 15.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 29.0871 APE9-dist-out 29.4078 None None None XRAY 2.15 0.253 0.287 C 303.0 271.0 13 33 28 5 [[17, 291]] 1.0 2vwi Homo sapiens STE_OXSR1_HUMAN STE 7.1e-94 319.8 1.0 257.0 257.0 163 164 165 167 169 46 63 67 143 145 144 146.0 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 2VWID O95747 6 298 527.0 ANP:1300 ATPlike Inactive DFGin 5.1794 16.2232 BLBtrans -101.51, 161.03 73.3, 16.0 -58.73, 139.72 167.14, 71.27 94.08, -129.9 out-out out 12.6631 Saltbr-out 12.4112 HRD-in -67.92, -49.61 77.45, -14.4 out-out-out SNCooo out-out ActLoopNT-out 7.9431 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -84.67, 122.36 APE9-dihe-na 118.58, -169.41 APE8-dihe-in -120.4, 114.0 APE8-rot-in 321.26 APE67-dihe-in -59.9, -22.77 -41.25, -46.54 APE12-dist-out 29.1338 APE11-dist-out 28.0731 APE10-dist-out 29.3143 APE9-dist-out 29.1611 None None None XRAY 2.15 0.253 0.287 D 303.0 284.0 9 33 24 9 [[17, 291]] 1.0 2vwi Homo sapiens STE_OXSR1_HUMAN STE 7.1e-94 319.8 1.0 257.0 257.0 163 164 165 167 169 46 63 67 143 145 144 146.0 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 2VWIA O95747 13 292 527.0 ANP:1294 ATPlike Inactive DFGin 8.898 15.6012 None -61.18, 158.62 -55.34, 143.64 -131.37, -0.25 74.39, 103.15 -56.05, -46.66 none-none none 999.0 Saltbr-none 999.0 HRD-in -71.19, -49.86 82.28, -11.12 none-out-out SNCnoo out-out ActLoopNT-out 5.9984 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -154.6 APE8-dihe-in -114.29, 105.56 APE8-rot-out 57.55 APE67-dihe-in -58.83, -26.11 -92.35, 9.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 28.1357 None None None XRAY 2.15 0.253 0.287 A 303.0 237.0 43 33 18 15 [[17, 291]] 1.0 2vwi Homo sapiens STE_OXSR1_HUMAN STE 7.1e-94 319.8 1.0 257.0 257.0 163 164 165 167 169 46 63 67 143 145 144 146.0 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE PAK1 PAK1_HUMAN 3Q4ZA Q13153 251 545 545.0 ANP:60800 ATPlike None DFGin 6.0861 15.9823 BLAminus -129.5, -163.35 61.16, 72.73 -92.37, 13.66 295.77, 79.36 -60.94, -29.11 out-none out 10.1866 Saltbr-none 999.0 HRD-in -71.1, -48.5 65.7, -2.93 none-in-in SNCnii in-in ActLoopNT-in 2.7668 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.35, 142.5 APE9-dihe-na 131.45, -160.89 APE8-dihe-in -120.18, 125.75 APE8-rot-in 304.74 APE67-dihe-in -64.8, -21.76 -41.32, -52.02 APE12-dist-in 9.9567 APE11-dist-in 11.7432 APE10-dist-in 6.0277 APE9-dist-in 3.3321 S259I,K299R,D389N,L516I None None XRAY 1.887 0.186 0.231 A 306.0 281.0 12 28 28 0 [[270, 521]] 1.0 3q4z Homo sapiens STE_PAK1_HUMAN STE 2e-93 318.4 1.0 257.0 257.0 406 407 408 410 412 299 315 319 386 388 387 389.0 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK4 PAK4_HUMAN 4FIFA O96013 296 589 591.0 ANP:1000 ATPlike Active DFGin 6.1318 13.8794 BLAminus -134.27, -172.64 55.78, 65.69 -91.22, 11.11 299.57, 98.92 -61.37, -20.58 in-in in 7.0457 Saltbr-in 3.1118 HRD-in -73.18, -47.2 74.11, -8.39 in-in-in SNCiii in-in ActLoopNT-in 2.8521 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.08, 134.89 APE9-dihe-na 136.18, -173.61 APE8-dihe-in -102.98, 119.55 APE8-rot-in 312.46 APE67-dihe-in -69.75, -26.2 -30.93, -52.34 APE12-dist-in 9.3183 APE11-dist-in 11.709 APE10-dist-in 5.8745 APE9-dist-in 3.2985 None SEP474 SEP474 XRAY 2.6 0.207 0.227 A 346.0 294.0 0 28 28 0 [[321, 572]] 1.0 4fif Homo sapiens STE_PAK4_HUMAN STE 3.1e-88 301.5 5.0 257.0 253.0 457 458 459 461 463 350 366 370 437 439 438 440.0 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIFB O96013 297 589 591.0 ANP:1000 ATPlike Active DFGin 5.8992 13.8496 BLAminus -129.09, -170.37 52.27, 68.51 -93.51, 10.45 301.97, 96.23 -63.09, -15.01 in-in in 7.0072 Saltbr-in 3.1674 HRD-in -65.39, -48.9 75.1, -7.5 in-in-in SNCiii in-in ActLoopNT-in 2.8012 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.88, 134.77 APE9-dihe-na 136.42, -174.06 APE8-dihe-in -101.96, 121.94 APE8-rot-in 314.36 APE67-dihe-in -72.79, -21.56 -33.03, -50.98 APE12-dist-in 9.2381 APE11-dist-in 11.7116 APE10-dist-in 5.8859 APE9-dist-in 3.3353 None SEP474 SEP474 XRAY 2.6 0.207 0.227 B 346.0 293.0 0 28 28 0 [[321, 572]] 1.0 4fif Homo sapiens STE_PAK4_HUMAN STE 3.1e-88 301.5 5.0 257.0 253.0 457 458 459 461 463 350 366 370 437 439 438 440.0 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIGA O96013 298 590 591.0 ANP:1001 ATPlike Inactive DFGin 5.9761 13.9947 BLAminus -134.45, -166.25 59.06, 57.3 -88.34, 9.13 298.9, 106.14 -61.58, -20.66 in-in in 7.1335 Saltbr-in 3.1682 HRD-in -77.25, -46.66 72.07, -3.1 in-in-out SNCiio in-out ActLoopNT-in 2.8596 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.47, 161.1 APE9-dihe-na 110.61, 163.55 APE8-dihe-in -79.54, 130.34 APE8-rot-out 29.96 APE67-dihe-in -76.38, -28.34 -35.31, -49.63 APE12-dist-in 9.4183 APE11-dist-in 11.5692 APE10-dist-in 5.6353 APE9-dist-in 3.3687 None SEP474 SEP474 XRAY 3.01 0.197 0.221 A 346.0 293.0 0 28 28 0 [[321, 572]] 1.0 4fig Homo sapiens STE_PAK4_HUMAN STE 3.1e-88 301.5 5.0 257.0 253.0 457 458 459 461 463 350 366 370 437 439 438 440.0 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4JDIA O96013 300 589 591.0 ANP:1000 ATPlike Active DFGin 6.2908 14.4701 BLAminus -134.26, 177.87 63.72, 71.58 -94.6, 13.78 289.77, 79.71 -54.15, -28.77 in-in in 6.9588 Saltbr-in 2.7368 HRD-in -72.82, -49.09 73.48, 2.76 in-in-in SNCiii in-in ActLoopNT-in 2.8295 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.62, 145.0 APE9-dihe-na 130.41, -160.49 APE8-dihe-in -120.53, 123.45 APE8-rot-in 305.94 APE67-dihe-in -63.49, -22.51 -36.89, -56.07 APE12-dist-in 8.7694 APE11-dist-in 11.535 APE10-dist-in 5.8739 APE9-dist-in 3.3267 None SEP474 SEP474 XRAY 1.85 0.194 0.233 A 346.0 290.0 0 28 28 0 [[321, 572]] 1.0 4jdi Homo sapiens STE_PAK4_HUMAN STE 3.1e-88 301.5 5.0 257.0 253.0 457 458 459 461 463 350 366 370 437 439 438 440.0 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 5UPKB O96013 300 588 591.0 ANP:60600 ATPlike Active DFGin 6.2722 14.1391 BLAminus -132.3, -169.35 61.71, 61.5 -87.86, 7.28 293.59, 93.96 -55.36, -28.3 in-in in 7.0771 Saltbr-in 3.3293 HRD-in -65.35, -49.16 70.36, 11.54 in-in-in SNCiii in-in ActLoopNT-in 2.9972 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.55, 149.52 APE9-dihe-na 120.09, -163.11 APE8-dihe-in -119.51, 121.87 APE8-rot-in 313.98 APE67-dihe-in -69.89, -18.98 -32.47, -57.41 APE12-dist-in 8.6225 APE11-dist-in 11.2666 APE10-dist-in 5.6159 APE9-dist-in 3.4261 None SEP474 SEP474 XRAY 2.4 0.22 0.264 B 346.0 289.0 0 28 28 0 [[321, 572]] 1.0 5upk Homo sapiens STE_PAK4_HUMAN STE 3.1e-88 301.5 5.0 257.0 253.0 457 458 459 461 463 350 366 370 437 439 438 440.0 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIEA O96013 49 590 591.0 ANP:1001 ATPlike Inactive DFGin 6.2776 14.0298 BLAminus -142.71, -177.86 63.75, 67.7 -92.97, 13.53 295.29, 98.36 -64.15, -7.0 in-out in 6.9911 Saltbr-out 3.9737 HRD-in -74.78, -36.69 67.65, -13.13 out-in-out SNCoio in-out ActLoopNT-in 2.8563 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -135.98, 139.97 APE9-dihe-na 123.6, -177.34 APE8-dihe-in -84.44, 139.76 APE8-rot-out 19.51 APE67-dihe-in -74.38, -37.99 -51.24, -48.18 APE12-dist-in 9.5152 APE11-dist-in 11.685 APE10-dist-in 5.9086 APE9-dist-in 3.5078 None SEP474 SEP474 XRAY 3.11 0.257 0.276 A 423.0 301.0 0 28 28 0 [[321, 572]] 1.0 4fie Homo sapiens STE_PAK4_HUMAN STE 5.6e-88 300.6 5.0 257.0 253.0 457 458 459 461 463 350 366 370 437 439 438 440.0 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIEB O96013 49 590 591.0 ANP:1001 ATPlike Inactive DFGin 6.2778 14.0307 BLAminus -142.24, -177.62 63.59, 67.55 -92.7, 13.49 295.33, 98.22 -64.04, -7.21 in-out in 6.9889 Saltbr-out 3.957 HRD-in -74.95, -36.21 66.97, -12.74 out-in-out SNCoio in-out ActLoopNT-in 2.8574 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.0, 139.86 APE9-dihe-na 123.6, -177.41 APE8-dihe-in -84.57, 139.76 APE8-rot-out 19.62 APE67-dihe-in -74.42, -37.89 -51.19, -48.15 APE12-dist-in 9.5148 APE11-dist-in 11.6892 APE10-dist-in 5.912 APE9-dist-in 3.5096 None SEP474 SEP474 XRAY 3.11 0.257 0.276 B 423.0 301.0 0 28 28 0 [[321, 572]] 1.0 4fie Homo sapiens STE_PAK4_HUMAN STE 5.6e-88 300.6 5.0 257.0 253.0 457 458 459 461 463 350 366 370 437 439 438 440.0 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 7S46A O96013 300 589 591.0 ANP:600 ATPlike Active DFGin 9.0206 14.3488 BLAminus -133.61, -177.07 54.75, 76.68 -92.18, 14.46 286.49, 80.35 -59.04, -19.55 in-in in 7.5337 Saltbr-in 2.867 HRD-in -69.43, -50.5 76.76, 2.96 in-in-in SNCiii in-in ActLoopNT-in 2.9219 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.73, 132.58 APE9-dihe-na 145.82, -167.86 APE8-dihe-in -110.13, 128.57 APE8-rot-in 305.26 APE67-dihe-in -70.79, -21.11 -38.41, -55.32 APE12-dist-in 9.0199 APE11-dist-in 11.5375 APE10-dist-in 5.7927 APE9-dist-in 3.2862 D440N,S474E None None XRAY 2.1 0.182 0.22 A 346.0 290.0 0 28 28 0 [[321, 572]] 1.0 7s46 Homo sapiens STE_PAK4_HUMAN STE 5.5e-87 297.4 5.0 257.0 253.0 457 458 459 461 463 350 366 370 437 439 438 440.0 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 7S47A O96013 300 589 591.0 ANP:600 ATPlike Active DFGin 9.2169 14.6465 BLAminus -126.8, -179.34 54.51, 73.91 -89.97, 15.41 285.81, 78.05 -59.21, -18.99 in-in in 7.7899 Saltbr-in 2.9309 HRD-in -66.64, -48.47 70.7, 6.89 in-in-in SNCiii in-in ActLoopNT-in 2.9139 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.53, 138.41 APE9-dihe-na 140.72, -164.27 APE8-dihe-in -114.61, 124.35 APE8-rot-in 304.9 APE67-dihe-in -66.22, -20.32 -36.39, -56.83 APE12-dist-in 9.0388 APE11-dist-in 11.4504 APE10-dist-in 5.7468 APE9-dist-in 3.4008 D440N,S474E None None XRAY 2.0 0.196 0.237 A 383.0 290.0 0 28 28 0 [[321, 572]] 1.0 7s47 Homo sapiens STE_PAK4_HUMAN STE 7.5e-87 297.0 5.0 257.0 253.0 457 458 459 461 463 350 366 370 437 439 438 440.0 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIGB O96013 298 590 591.0 ANP:602 ATPlike Inactive DFGin 5.9786 13.8453 None -136.1, -40.27 -82.41, 70.29 -85.54, 12.48 305.29, 106.7 -66.77, -24.27 in-in in 7.0074 Saltbr-in 3.0472 HRD-in -63.37, -48.9 73.21, -4.05 in-in-in SNCiii in-in ActLoopNT-in 2.9294 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.8, 141.64 APE9-dihe-na 130.69, -165.45 APE8-dihe-in -110.43, 122.9 APE8-rot-in 324.7 APE67-dihe-in -77.33, -31.89 -29.23, -51.11 APE12-dist-in 9.7059 APE11-dist-in 11.7431 APE10-dist-in 5.9203 APE9-dist-in 3.3864 None SEP474 SEP474 XRAY 3.01 0.197 0.221 B 346.0 293.0 0 28 28 0 [[321, 572]] 1.0 4fig Homo sapiens STE_PAK4_HUMAN STE 3.1e-88 301.5 5.0 257.0 253.0 457 458 459 461 463 350 366 370 437 439 438 440.0 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE STK24 STK24_HUMAN 4QMLA Q9Y6E0 30 310 443.0 ANP:60403 ATPlike Active DFGin 6.598 15.1775 BLAminus -130.38, 172.22 70.9, 79.24 -104.53, 20.01 285.96, 83.16 -61.35, -25.21 in-in in 9.0649 Saltbr-in 2.9268 HRD-in -70.82, -51.82 74.23, -2.97 in-in-in SNCiii in-in ActLoopNT-in 2.8482 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.04, 155.96 APE9-dihe-na 125.92, -168.67 APE8-dihe-in -115.63, 119.31 APE8-rot-in 310.36 APE67-dihe-in -60.1, -29.49 -47.33, -42.77 APE12-dist-in 8.2764 APE11-dist-in 11.0512 APE10-dist-in 5.5577 APE9-dist-in 3.3857 None TPO190 TPO190 XRAY 1.882 0.19 0.23 A 310.0 281.0 0 28 28 0 [[36, 286]] 1.0 4qml Homo sapiens STE_STK24_HUMAN STE 3.9e-100 340.4 1.0 257.0 257.0 173 174 175 177 179 65 82 86 153 155 154 156.0 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK3 STK3_HUMAN 6AO5A Q13188 28 488 491.0 ANP:501 ATPlike Inactive DFGin 5.7624 13.2545 BLAplus -144.87, 157.4 64.61, 76.09 -109.93, -46.63 13.82, 108.09 -89.31, 27.29 out-out out 12.9083 Saltbr-out 12.1164 HRD-in -60.56, -48.36 76.32, -35.33 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nooo APE10-dihe-na -164.34, 157.95 APE9-dihe-na -118.75, -167.2 APE8-dihe-in -63.94, 121.38 APE8-rot-out 166.95 APE67-dihe-out -86.4, -39.81 -115.82, 59.17 APE12-dist-none 999.0 APE11-dist-out 17.8946 APE10-dist-out 16.1523 APE9-dist-out 11.0624 D146N None None XRAY 2.955 0.236 0.256 A 362.0 321.0 27 28 16 12 [[27, 278]] 1.0 6ao5 Homo sapiens STE_STK3_HUMAN STE 3.6e-100 340.7 2.0 257.0 256.0 163 164 165 167 169 56 70 74 143 145 144 146.0 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 4LGDA Q13188 16 488 491.0 ANP:501 ATPlike Inactive DFGin 6.0177 17.0204 BLBminus -145.52, -179.3 43.95, 67.54 -70.27, 152.23 281.57, 44.13 -80.59, 163.91 out-out out 10.8887 Saltbr-out 5.7943 HRD-in -73.7, -41.12 68.58, 5.1 out-out-out SNCooo out-out ActLoopNT-out 8.7174 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -60.16, -34.45 APE9-dihe-na -67.84, -18.95 APE8-dihe-in -138.32, 78.16 APE8-rot-in 307.08 APE67-dihe-in -67.01, -21.51 -99.04, 14.35 APE12-dist-in 12.4566 APE11-dist-in 10.1948 APE10-dist-out 15.2694 APE9-dist-out 12.7523 D146N None None XRAY 3.05 0.202 0.244 A 378.0 350.0 0 28 28 0 [[27, 278]] 1.0 4lgd Homo sapiens STE_STK3_HUMAN STE 4.1e-100 340.6 2.0 257.0 256.0 163 164 165 167 169 56 70 74 143 145 144 146.0 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 4LGDB Q13188 10 488 491.0 ANP:501 ATPlike Inactive DFGin 6.1597 16.6917 BLBminus -138.64, 169.86 44.76, 62.12 -62.36, 151.89 285.61, 26.54 -88.9, 160.74 out-out out 10.7358 Saltbr-out 6.0218 HRD-in -77.36, -41.29 64.17, 12.1 out-out-out SNCooo out-out ActLoopNT-out 9.006 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -74.54, -22.15 APE9-dihe-na -64.82, -19.37 APE8-dihe-in -144.49, 84.11 APE8-rot-in 305.11 APE67-dihe-in -63.85, -34.86 -100.76, 15.67 APE12-dist-in 12.5954 APE11-dist-in 10.2532 APE10-dist-out 15.0464 APE9-dist-out 12.7218 D146N None None XRAY 3.05 0.202 0.244 B 378.0 350.0 0 28 28 0 [[27, 278]] 1.0 4lgd Homo sapiens STE_STK3_HUMAN STE 4.1e-100 340.6 2.0 257.0 256.0 163 164 165 167 169 56 70 74 143 145 144 146.0 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 4LGDC Q13188 12 490 491.0 ANP:501 ATPlike Inactive DFGin 6.3594 17.1177 BLBminus -149.78, 166.61 51.14, 65.46 -62.65, 153.33 284.02, 26.74 -77.49, 169.34 out-out out 10.5496 Saltbr-out 5.6105 HRD-in -72.97, -46.37 72.83, -1.88 out-out-out SNCooo out-out ActLoopNT-out 9.0368 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -57.36, -33.07 APE9-dihe-na -66.61, -18.79 APE8-dihe-in -138.0, 80.15 APE8-rot-in 301.29 APE67-dihe-in -70.28, -28.9 -100.7, 15.38 APE12-dist-in 12.4466 APE11-dist-in 10.0303 APE10-dist-out 15.1965 APE9-dist-out 12.6699 D146N None None XRAY 3.05 0.202 0.244 C 378.0 349.0 7 28 28 0 [[27, 278]] 1.0 4lgd Homo sapiens STE_STK3_HUMAN STE 4.1e-100 340.6 2.0 257.0 256.0 163 164 165 167 169 56 70 74 143 145 144 146.0 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 4LGDD Q13188 11 489 491.0 ANP:501 ATPlike Inactive DFGin 6.2676 16.8909 BLBminus -143.39, 170.34 44.57, 62.98 -62.31, 161.36 279.47, 45.38 -101.43, 151.87 out-out out 10.7942 Saltbr-out 6.2875 HRD-in -67.38, -41.94 64.94, 10.19 out-out-out SNCooo out-out ActLoopNT-out 8.7906 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -65.98, -30.48 APE9-dihe-na -65.09, -18.33 APE8-dihe-in -145.24, 79.51 APE8-rot-in 304.52 APE67-dihe-in -64.33, -26.69 -98.63, 11.94 APE12-dist-in 12.4327 APE11-dist-in 10.3059 APE10-dist-out 15.3766 APE9-dist-out 12.7507 D146N None None XRAY 3.05 0.202 0.244 D 378.0 338.0 0 28 28 0 [[27, 278]] 1.0 4lgd Homo sapiens STE_STK3_HUMAN STE 4.1e-100 340.6 2.0 257.0 256.0 163 164 165 167 169 56 70 74 143 145 144 146.0 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STE STRADA STRAA_HUMAN 2WTKB Q7RTN6 61 431 431.0 ANP:432 ATPlike Pseudo DFGin 5.1159 13.443 BLAminus -117.01, -150.73 71.3, 24.64 -54.34, -28.38 297.58, 14.45 -57.14, -26.88 out-none out 10.0156 Saltbr-none 999.0 HRD-in -75.87, -56.89 78.73, -4.32 none-in-out SNCnio in-out ActLoopNT-in 2.9208 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_iooo APE10-dihe-na -50.59, -53.43 APE9-dihe-na -67.53, -3.25 APE8-dihe-out -106.64, -20.66 APE8-rot-na 143.84 APE67-dihe-in -56.31, -21.98 -28.24, -53.75 APE12-dist-in 8.271 APE11-dist-out 7.4561 APE10-dist-out 12.8431 APE9-dist-out 9.3713 None None None XRAY 2.65 0.24 0.291 B 373.0 311.0 52 35 35 0 [[69, 379]] 1.0 2wtk Homo sapiens STE_STRADA_HUMAN STE 4e-87 298.0 1.0 257.0 257.0 212 213 214 216 218 100 118 122 192 194 193 195.0 261 247 242 241 240 239 238 237 236 148 STE20-related kinase adapter protein alpha
STE STRADA STRAA_HUMAN 2WTKE Q7RTN6 60 431 431.0 ANP:432 ATPlike Pseudo DFGin 5.0759 13.5912 BLAminus -114.47, -147.76 66.21, 35.38 -66.23, -19.97 288.54, 169.08 -50.33, -33.69 in-none in 9.934 Saltbr-none 999.0 HRD-in -67.35, -61.05 78.73, -1.12 none-in-out SNCnio in-out ActLoopNT-in 2.861 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_iooo APE10-dihe-na -48.76, -50.43 APE9-dihe-na -62.69, -41.12 APE8-dihe-out -68.21, -28.45 APE8-rot-na 167.78 APE67-dihe-in -49.8, -37.77 -23.43, -57.21 APE12-dist-in 8.1186 APE11-dist-out 7.6425 APE10-dist-out 12.951 APE9-dist-out 9.4176 None None None XRAY 2.65 0.24 0.291 E 373.0 308.0 52 35 35 0 [[69, 379]] 1.0 2wtk Homo sapiens STE_STRADA_HUMAN STE 4e-87 298.0 1.0 257.0 257.0 212 213 214 216 218 100 118 122 192 194 193 195.0 261 247 242 241 240 239 238 237 236 148 STE20-related kinase adapter protein alpha
STE TNIK TNIK_HUMAN 7XZRB Q9UKE5 12 312 1360.0 ANP:1401 ATPlike Active DFGin 6.4394 15.1629 BLAminus -131.61, 176.54 70.33, 83.31 -101.27, 21.61 286.01, 77.74 -67.8, -30.96 in-in in 9.1256 Saltbr-in 2.5815 HRD-in -64.36, -58.64 76.74, 3.35 in-in-in SNCiii in-in ActLoopNT-in 2.9312 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.27, 150.43 APE9-dihe-na 126.35, -168.16 APE8-dihe-in -105.07, 123.33 APE8-rot-in 308.43 APE67-dihe-in -61.4, -25.19 -44.62, -54.45 APE12-dist-in 8.7003 APE11-dist-in 11.7054 APE10-dist-in 6.0779 APE9-dist-in 3.7049 None TPO181,TPO187 TPO181,TPO187 XRAY 2.26 0.184 0.226 B 306.0 301.0 0 28 28 0 [[25, 289]] 1.0 7xzr Homo sapiens STE_TNIK_HUMAN STE 3e-105 357.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 7XZRA Q9UKE5 12 310 1360.0 ANP:1401 Type1.5_Front Active DFGin 6.2745 14.1933 BLAminus -134.39, 177.59 74.52, 87.23 -110.98, 20.38 291.6, 89.06 -61.78, -40.23 in-in in 8.5907 Saltbr-in 2.8438 HRD-in -69.77, -51.11 71.86, 1.74 in-in-in SNCiii in-in ActLoopNT-in 2.9118 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.22, 154.28 APE9-dihe-na 131.69, -173.17 APE8-dihe-in -101.89, 120.07 APE8-rot-in 317.88 APE67-dihe-in -57.93, -30.58 -42.35, -51.61 APE12-dist-in 8.5949 APE11-dist-in 12.0463 APE10-dist-in 6.4403 APE9-dist-in 4.3071 None TPO181,TPO187 TPO181,TPO187 XRAY 2.26 0.184 0.226 A 306.0 299.0 0 28 28 0 [[25, 289]] 1.0 7xzr Homo sapiens STE_TNIK_HUMAN STE 3e-105 357.1 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TKL ACVR1 ACVR1_HUMAN 6UNQA Q04771 206 496 509.0 ANP:501 ATPlike Inactive DFGin 7.4202 13.3371 BLAminus -125.65, 175.43 76.87, 82.94 -97.73, 22.73 293.77, 158.03 -74.66, -11.32 in-out in 8.4086 Saltbr-out 4.371 HRD-in -82.52, -56.03 82.09, -4.01 out-in-out SNCoio in-out ActLoopNT-in 2.8141 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.89, 171.23 APE9-dihe-na -69.6, 161.61 APE8-dihe-in -54.69, 120.18 APE8-rot-in 304.53 APE67-dihe-in -58.55, -27.57 -58.47, -38.91 APE12-dist-in 10.4635 APE11-dist-out 6.6677 APE10-dist-out 9.0755 APE9-dist-in 3.9229 K493A None None XRAY 2.4 0.221 0.283 A 330.0 289.0 3 32 32 0 [[207, 497]] 1.0 6unq Homo sapiens TKL_ACVR1_HUMAN TKL 5e-85 291.3 2.0 266.0 265.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 6UNRA Q04771 208 496 509.0 ANP:501 ATPlike Inactive DFGin 7.2924 13.3423 BLAminus -137.01, 173.22 63.77, 86.25 -97.63, 26.62 300.72, 163.44 -66.11, -21.39 in-out in 8.4001 Saltbr-out 4.7436 HRD-in -74.93, -61.2 87.34, -7.73 out-in-out SNCoio in-out ActLoopNT-in 2.8371 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -115.39, 160.07 APE9-dihe-na -63.13, 170.03 APE8-dihe-in -59.34, 121.87 APE8-rot-in 302.11 APE67-dihe-in -65.55, -35.42 -57.38, -33.57 APE12-dist-in 10.4511 APE11-dist-out 6.8385 APE10-dist-out 9.1104 APE9-dist-in 3.9303 None None None XRAY 2.2 0.246 0.302 A 330.0 286.0 4 32 32 0 [[207, 497]] 1.0 6unr Homo sapiens TKL_ACVR1_HUMAN TKL 7.3e-85 290.8 2.0 266.0 265.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ARAF ARAF_HUMAN 9AXMB P10398 302 574 606.0 ANP:60602 ATPlike Inactive DFGin 4.5967 13.3268 BLBplus -134.26, 172.61 61.7, 46.72 -103.54, 150.88 54.31, 89.4 54.71, 36.64 out-out out 11.556 Saltbr-out 10.4941 HRD-in -66.55, -46.59 76.65, -12.19 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -153.94 APE8-dihe-in -77.25, 142.54 APE8-rot-out 182.59 APE67-dihe-in -67.09, -22.55 -72.82, -26.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.5235 Y301D,Y302D None None XRAY 2.42 0.263 0.301 B 280.0 254.0 19 30 13 17 [[310, 569]] 1.0 9axm Homo sapiens TKL_ARAF_HUMAN TKL 1.1e-77 267.1 2.0 266.0 265.0 446 447 448 450 452 336 354 358 426 428 427 429.0 491 476 471 470 469 468 467 466 465 383 Serine/threonine-protein kinase A-Raf
TKL BRAF BRAF_HUMAN 9AXXB P15056 449 721 766.0 ANP:60801 ATPlike Inactive DFGin 6.2724 14.156 BLAminus -118.96, -160.68 44.13, 79.21 -91.3, 29.71 285.28, 70.2 -64.85, -24.03 in-out in 8.9679 Saltbr-out 6.0423 HRD-in -74.42, -44.59 66.93, 5.21 out-in-in SNCoii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.1, 120.32 APE9-dihe-na 137.74, -165.97 APE8-dihe-in -102.01, 122.38 APE8-rot-in 304.65 APE67-dihe-in -63.13, -30.61 -66.04, -26.1 APE12-dist-in 13.0987 APE11-dist-in 12.6277 APE10-dist-in 7.4721 APE9-dist-in 5.708 None None None XRAY 2.07 0.215 0.248 B 280.0 261.0 12 30 24 6 [[457, 716]] 1.0 9axx Homo sapiens TKL_BRAF_HUMAN TKL 7.8e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 9AXYA P15056 448 722 766.0 ANP:801 ATPlike Inactive DFGin 5.9166 13.5406 BLBplus -133.51, 174.13 59.27, 33.71 -86.77, 154.56 49.71, 87.92 69.37, -142.48 out-out out 14.0958 Saltbr-out 13.0065 HRD-in -70.93, -41.64 75.57, -39.02 out-out-out SNCooo out-out ActLoopNT-out 9.0693 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -141.06, 145.96 APE9-dihe-na 71.75, -130.61 APE8-dihe-in -87.56, 149.58 APE8-rot-out 200.58 APE67-dihe-in -69.57, -29.74 -96.77, -9.15 APE12-dist-out 14.1942 APE11-dist-out 15.515 APE10-dist-out 11.6629 APE9-dist-out 9.6767 None None None XRAY 3.6 0.19 0.237 A 280.0 275.0 0 30 30 0 [[457, 716]] 1.0 9axy Homo sapiens TKL_BRAF_HUMAN TKL 7.8e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 6PP9A P15056 447 722 766.0 ANP:801 ATPlike Inactive DFGin 5.3423 13.4984 BLBplus -130.79, 177.54 57.37, 43.96 -96.57, 156.54 49.86, 89.0 63.47, -135.71 out-out out 14.313 Saltbr-out 12.6898 HRD-in -66.97, -47.8 65.51, 3.6 out-out-out SNCooo out-out ActLoopNT-out 9.2557 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -142.44, 146.23 APE9-dihe-na 73.26, -154.57 APE8-dihe-in -71.36, 154.2 APE8-rot-out 182.15 APE67-dihe-in -61.64, -19.53 -112.25, -5.75 APE12-dist-out 15.2013 APE11-dist-out 15.9004 APE10-dist-out 12.6934 APE9-dist-out 10.139 None None None XRAY 2.59 0.222 0.245 A 283.0 276.0 0 30 30 0 [[457, 716]] 1.0 6pp9 Homo sapiens TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 6V2WA P15056 447 721 766.0 ANP:801 ATPlike Inactive DFGin 5.532 13.7036 BLBplus -135.72, 175.83 57.63, 35.46 -91.96, 158.82 53.8, 96.09 64.15, -137.39 out-out out 14.4746 Saltbr-out 12.4333 HRD-in -69.37, -44.53 66.04, 8.13 out-out-out SNCooo out-out ActLoopNT-out 8.9897 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -146.39, 170.31 APE9-dihe-na 111.41, -172.95 APE8-dihe-in -92.84, 135.37 APE8-rot-out 52.69 APE67-dihe-in -65.1, -26.74 -72.43, -22.76 APE12-dist-out 14.7285 APE11-dist-out 14.8979 APE10-dist-out 12.1593 APE9-dist-out 6.2561 None None None XRAY 3.12 0.189 0.237 A 283.0 275.0 0 30 30 0 [[457, 716]] 1.0 6v2w Homo sapiens TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0TA P15056 448 721 766.0 ANP:801 ATPlike Inactive DFGin 5.4827 13.6452 BLBplus -101.53, -171.54 49.12, 40.35 -93.39, 158.36 49.68, 91.24 67.74, -141.33 out-out out 14.6334 Saltbr-out 13.4177 HRD-in -63.36, -50.98 81.19, -14.99 out-out-out SNCooo out-out ActLoopNT-out 9.0962 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iooo APE10-dihe-na -146.63, 169.35 APE9-dihe-na 113.78, -178.56 APE8-dihe-in -87.12, 141.18 APE8-rot-out 208.64 APE67-dihe-out -59.38, 160.81 -70.93, -34.96 APE12-dist-in 13.663 APE11-dist-out 15.2769 APE10-dist-out 12.4492 APE9-dist-out 6.6885 None None None XRAY 3.19 0.199 0.254 A 283.0 274.0 0 30 30 0 [[457, 716]] 1.0 7m0t Homo sapiens TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0UA P15056 449 722 766.0 ANP:801 ATPlike Inactive DFGin 5.8262 13.5453 BLBplus -114.76, -174.76 53.19, 33.71 -86.73, 158.23 49.19, 93.22 61.58, -136.88 out-out out 14.5076 Saltbr-out 13.6281 HRD-in -66.62, -51.93 79.28, -5.3 out-out-out SNCooo out-out ActLoopNT-out 8.9683 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -137.94, 171.17 APE9-dihe-na 125.59, 173.92 APE8-dihe-in -78.53, 136.46 APE8-rot-out 49.62 APE67-dihe-in -63.36, -26.84 -75.55, -22.51 APE12-dist-out 14.5901 APE11-dist-out 14.4763 APE10-dist-out 12.1021 APE9-dist-out 6.3314 None None None XRAY 3.09 0.193 0.23 A 283.0 274.0 0 30 30 0 [[457, 716]] 1.0 7m0u Homo sapiens TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0VA P15056 449 722 766.0 ANP:801 ATPlike Inactive DFGin 5.7413 13.2905 BLBplus -118.84, -178.01 61.17, 44.22 -99.98, 160.93 40.29, 99.45 62.33, -140.62 out-out out 14.1107 Saltbr-out 13.1408 HRD-in -76.68, -47.66 79.51, -34.29 out-out-out SNCooo out-out ActLoopNT-out 9.3238 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -140.71, 145.59 APE9-dihe-na 81.77, -131.39 APE8-dihe-in -106.29, 148.31 APE8-rot-out 201.4 APE67-dihe-in -54.29, -30.39 -107.29, -13.89 APE12-dist-in 13.9087 APE11-dist-out 15.7766 APE10-dist-out 12.613 APE9-dist-out 10.1626 None None None XRAY 3.16 0.188 0.234 A 283.0 274.0 0 30 30 0 [[457, 716]] 1.0 7m0v Homo sapiens TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0WA P15056 448 721 766.0 ANP:801 ATPlike Inactive DFGin 5.6996 13.563 BLBplus -128.57, -174.24 58.52, 36.11 -93.32, 163.98 47.26, 91.72 57.0, -141.37 out-out out 14.2729 Saltbr-out 13.0439 HRD-in -64.47, -50.11 78.2, -6.17 out-out-out SNCooo out-out ActLoopNT-out 8.9804 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -140.16, 158.71 APE9-dihe-na 121.26, -178.69 APE8-dihe-in -87.94, 138.93 APE8-rot-out 43.99 APE67-dihe-in -65.6, -30.89 -79.08, -13.62 APE12-dist-out 14.335 APE11-dist-out 15.3422 APE10-dist-out 12.1341 APE9-dist-out 6.6508 None None None XRAY 3.09 0.197 0.233 A 283.0 274.0 0 30 30 0 [[457, 716]] 1.0 7m0w Homo sapiens TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0XA P15056 447 722 766.0 ANP:801 ATPlike Inactive DFGin 5.4453 13.4953 BLBplus -123.82, 174.92 60.79, 42.33 -96.45, 161.16 49.04, 90.67 58.85, -140.33 out-out out 14.2652 Saltbr-out 13.0632 HRD-in -65.53, -50.34 78.03, -10.0 out-out-out SNCooo out-out ActLoopNT-out 9.2452 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -141.24, 149.26 APE9-dihe-na 65.43, -162.66 APE8-dihe-in -61.59, 142.77 APE8-rot-out 179.57 APE67-dihe-in -62.52, -26.23 -97.92, -3.07 APE12-dist-out 15.152 APE11-dist-out 15.9657 APE10-dist-out 12.6259 APE9-dist-out 10.0835 None None None XRAY 2.47 0.18 0.215 A 283.0 276.0 0 30 30 0 [[457, 716]] 1.0 7m0x Homo sapiens TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0YA P15056 447 721 766.0 ANP:801 ATPlike Inactive DFGin 5.9246 13.72 BLBplus -130.12, 178.08 53.67, 39.87 -94.09, 143.26 51.07, 86.66 77.46, -140.33 out-out out 14.4541 Saltbr-out 12.4204 HRD-in -66.6, -53.86 81.89, -14.1 out-out-out SNCooo out-out ActLoopNT-out 8.9677 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -138.96, 162.77 APE9-dihe-na 110.62, -175.34 APE8-dihe-in -77.87, 138.5 APE8-rot-out 52.44 APE67-dihe-in -64.93, -32.89 -83.52, -17.07 APE12-dist-out 14.2255 APE11-dist-out 15.2702 APE10-dist-out 12.0065 APE9-dist-out 6.7809 None None None XRAY 3.45 0.196 0.218 A 283.0 275.0 0 30 30 0 [[457, 716]] 1.0 7m0y Homo sapiens TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0ZA P15056 449 721 766.0 ANP:801 ATPlike Inactive DFGin 5.5912 13.5576 BLBplus -131.23, -177.35 57.24, 31.09 -88.02, 155.4 49.99, 89.35 66.37, -137.56 out-out out 14.3781 Saltbr-out 12.7969 HRD-in -63.1, -49.11 70.7, -2.29 out-out-out SNCooo out-out ActLoopNT-out 8.9341 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -140.88, 158.66 APE9-dihe-na 126.45, -167.01 APE8-dihe-in -93.79, 132.25 APE8-rot-out 208.38 APE67-dihe-in -66.35, -24.31 -75.16, -20.55 APE12-dist-in 12.9869 APE11-dist-out 14.9185 APE10-dist-out 11.8215 APE9-dist-out 6.3849 None None None XRAY 3.12 0.193 0.225 A 283.0 273.0 0 30 30 0 [[457, 716]] 1.0 7m0z Homo sapiens TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 9ECUA P15056 447 722 766.0 ANP:801 ATPlike Inactive DFGin 5.3951 13.5556 BLBplus -125.65, 169.46 60.46, 40.01 -87.45, 154.95 47.27, 91.45 64.75, -132.56 out-out out 13.9748 Saltbr-out 13.7365 HRD-in -64.53, -58.29 87.19, -19.63 out-out-out SNCooo out-out ActLoopNT-out 9.2329 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -128.75, 123.72 APE9-dihe-na 163.56, -169.21 APE8-dihe-in -104.16, 118.8 APE8-rot-in 298.64 APE67-dihe-in -60.82, -35.98 -59.26, -34.28 APE12-dist-out 14.6908 APE11-dist-out 15.132 APE10-dist-out 11.51 APE9-dist-out 6.3102 None None None XRAY 3.46 0.202 0.237 A 284.0 276.0 0 30 30 0 [[457, 716]] 1.0 9ecu Homo sapiens TKL_BRAF_HUMAN TKL 8.2e-82 280.6 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL IRAK4 IRAK4_HUMAN 2OIDA Q9NWZ3 164 458 460.0 ANP:1 ATPlike Inactive DFGin 6.9661 14.6844 BLAminus -127.55, 175.38 65.24, 82.27 -102.22, 23.11 306.08, 83.19 -64.75, -29.47 out-out out 11.8323 Saltbr-out 5.6903 HRD-in -73.12, -50.9 80.09, -6.55 out-in-in SNCoii in-in ActLoopNT-in 2.8231 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.88, 151.66 APE9-dihe-na 147.16, -164.5 APE8-dihe-in -113.74, 115.19 APE8-rot-in 308.34 APE67-dihe-in -64.44, -17.27 -37.39, -54.71 APE12-dist-in 9.8258 APE11-dist-in 11.5381 APE10-dist-in 6.0721 APE9-dist-in 3.8073 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.244 0.295 A 301.0 266.0 29 30 26 4 [[183, 456]] 1.0 2oid Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OIDB Q9NWZ3 164 459 460.0 ANP:2 ATPlike Inactive DFGin 6.94 14.7103 BLAminus -122.34, 171.98 72.6, 82.12 -104.43, 15.54 299.16, 90.11 -59.64, -29.05 in-out in 8.9076 Saltbr-out 3.9298 HRD-in -75.58, -47.6 78.52, -5.87 out-in-in SNCoii in-in ActLoopNT-in 2.7304 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.71, 158.05 APE9-dihe-na 142.8, -157.21 APE8-dihe-in -121.23, 117.8 APE8-rot-in 309.19 APE67-dihe-in -67.67, -11.87 -44.28, -49.35 APE12-dist-in 10.1904 APE11-dist-in 11.7427 APE10-dist-in 6.5221 APE9-dist-in 3.7233 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.244 0.295 B 301.0 274.0 22 30 24 6 [[183, 456]] 1.0 2oid Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OIDC Q9NWZ3 166 458 460.0 ANP:3 ATPlike Inactive DFGin 6.806 13.9727 BLAminus -130.4, 175.52 61.07, 75.53 -96.05, 32.37 309.84, 82.72 -74.67, -28.22 in-out in 8.9014 Saltbr-out 4.0238 HRD-in -62.6, -55.98 80.8, 1.53 out-in-in SNCoii in-in ActLoopNT-in 3.032 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.92, 158.28 APE9-dihe-na 138.01, -176.06 APE8-dihe-in -106.21, 116.22 APE8-rot-in 304.08 APE67-dihe-in -63.21, -15.57 -55.27, -41.4 APE12-dist-in 9.6871 APE11-dist-in 11.4204 APE10-dist-in 6.3612 APE9-dist-in 3.8779 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.244 0.295 C 301.0 259.0 34 30 24 6 [[183, 456]] 1.0 2oid Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OIDD Q9NWZ3 164 459 460.0 ANP:4 ATPlike Active DFGin 6.5602 13.9721 BLAminus -129.12, -177.03 59.13, 109.88 -131.38, 17.54 304.54, 87.5 -68.37, -4.63 in-in in 8.1503 Saltbr-in 3.5198 HRD-in -75.54, -51.34 70.58, 2.03 in-in-in SNCiii in-in ActLoopNT-in 2.7649 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.72, 147.52 APE9-dihe-na 139.0, -173.6 APE8-dihe-in -107.1, 118.58 APE8-rot-in 309.04 APE67-dihe-in -62.68, -15.82 -47.4, -49.91 APE12-dist-in 9.7501 APE11-dist-in 11.4404 APE10-dist-in 5.9279 APE9-dist-in 3.9698 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.244 0.295 D 301.0 277.0 19 30 27 3 [[183, 456]] 1.0 2oid Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6EGFB Q9NWZ3 164 460 460.0 ANP:501 ATPlike Inactive DFGin 5.6133 16.8833 BLBtrans -116.63, 167.73 64.0, 27.84 -68.07, 138.11 161.96, 71.15 80.16, -16.86 out-out out 13.6461 Saltbr-out 13.3901 HRD-in -72.08, -42.87 70.74, 1.24 out-out-out SNCooo out-out ActLoopNT-out 6.1127 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 31.47 APE8-rot-out 178.98 APE67-dihe-in -65.08, -16.47 -76.23, -17.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.61 0.206 0.229 B 302.0 285.0 12 30 18 12 [[183, 456]] 1.0 6egf Homo sapiens TKL_IRAK4_HUMAN TKL 2.6e-83 285.5 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL KSR1 KSR1_HUMAN 9AXHC Q8IVT5 614 881 923.0 ANP:60901 ATPlike Pseudo DFGin 5.2299 13.2395 BLBplus -124.42, 164.81 64.66, 43.46 -90.48, 143.73 53.91, 91.43 61.22, 55.23 out-none out 14.31 Saltbr-none 999.0 HRD-in -67.1, -51.8 77.02, -11.89 none-out-out SNCnoo out-out ActLoopNT-out 7.6573 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -64.2, -39.05 APE9-dihe-na -59.17, -48.89 APE8-dihe-out -66.09, -38.64 APE8-rot-na 184.07 APE67-dihe-in -61.76, -22.42 -60.74, -36.73 APE12-dist-out 16.8898 APE11-dist-out 15.9594 APE10-dist-out 20.4992 APE9-dist-out 12.2193 None None None XRAY 2.81 0.206 0.253 C 283.0 259.0 10 33 26 7 [[613, 879]] 1.0 9axh Homo sapiens TKL_KSR1_HUMAN TKL 2.1e-68 236.7 2.0 267.0 266.0 749 750 751 753 755 639 657 661 730 732 731 733.0 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 9AXHD Q8IVT5 613 881 923.0 ANP:60901 ATPlike Pseudo DFGin 5.2463 13.2292 BLBplus -126.56, 169.35 63.03, 47.69 -96.52, 141.09 54.28, 88.59 76.52, 29.36 out-none out 14.4881 Saltbr-none 999.0 HRD-in -67.9, -47.78 73.32, -2.62 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -60.7, -40.23 APE9-dihe-na -60.83, -42.14 APE8-dihe-out -70.49, -38.33 APE8-rot-na 183.99 APE67-dihe-in -64.38, -16.08 -60.51, -36.42 APE12-dist-out 17.0875 APE11-dist-out 16.2284 APE10-dist-out 20.7005 APE9-dist-out 12.5971 None None None XRAY 2.81 0.206 0.253 D 283.0 249.0 20 33 20 13 [[613, 879]] 1.0 9axh Homo sapiens TKL_KSR1_HUMAN TKL 2.1e-68 236.7 2.0 267.0 266.0 749 750 751 753 755 639 657 661 730 732 731 733.0 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JUWB Q8IVT5 601 881 923.0 ANP:901 ATPlike Pseudo DFGin 5.4788 13.4359 BLBplus -116.78, 175.7 58.02, 37.9 -91.13, 161.87 61.57, 85.28 62.4, -8.11 out-none out 13.3396 Saltbr-none 999.0 HRD-in -64.36, -50.52 68.6, 3.9 none-out-out SNCnoo out-out ActLoopNT-out 7.1258 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -75.12, -46.44 APE9-dihe-na -49.25, -41.63 APE8-dihe-out -65.16, -50.29 APE8-rot-na 182.96 APE67-dihe-in -55.58, -30.38 -61.8, -31.6 APE12-dist-out 17.6819 APE11-dist-out 16.5985 APE10-dist-out 21.0265 APE9-dist-out 12.8341 None None None XRAY 2.88 0.245 0.286 B 334.0 277.0 4 33 29 4 [[613, 879]] 1.0 7juw Homo sapiens TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2.0 267.0 266.0 749 750 751 753 755 639 657 661 730 732 731 733.0 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JUXA Q8IVT5 600 881 923.0 ANP:901 ATPlike Pseudo DFGin 5.3021 12.8866 BLBplus -130.76, 153.55 60.79, 41.41 -77.85, 152.64 59.13, 80.46 58.16, 12.6 out-none out 13.5859 Saltbr-none 999.0 HRD-out -82.48, 84.18 -62.97, 148.26 none-out-out SNCnoo out-out ActLoopNT-out 7.0623 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -85.2, -42.07 APE9-dihe-na -55.8, -29.41 APE8-dihe-out -77.82, -37.67 APE8-rot-na 188.53 APE67-dihe-in -61.89, -19.45 -62.94, -36.24 APE12-dist-out 17.4266 APE11-dist-out 16.2348 APE10-dist-out 20.6238 APE9-dist-out 14.0574 None None None XRAY 3.34 0.265 0.283 A 334.0 278.0 4 33 29 4 [[613, 879]] 1.0 7jux Homo sapiens TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2.0 267.0 266.0 749 750 751 753 755 639 657 661 730 732 731 733.0 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JUYB Q8IVT5 601 881 923.0 ANP:901 ATPlike Pseudo DFGin 5.6126 13.191 BLBplus -117.18, 175.18 57.71, 38.02 -91.22, 161.18 61.47, 85.63 62.09, -7.96 out-none out 13.3948 Saltbr-none 999.0 HRD-in -64.77, -50.93 68.2, 3.89 none-out-out SNCnoo out-out ActLoopNT-out 7.0671 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -74.87, -46.12 APE9-dihe-na -49.26, -41.38 APE8-dihe-out -64.88, -49.41 APE8-rot-na 183.95 APE67-dihe-in -56.03, -30.73 -61.35, -31.75 APE12-dist-out 17.5559 APE11-dist-out 16.5246 APE10-dist-out 20.9468 APE9-dist-out 12.7704 None None None XRAY 3.096 0.248 0.257 B 334.0 276.0 5 33 28 5 [[613, 879]] 1.0 7juy Homo sapiens TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2.0 267.0 266.0 749 750 751 753 755 639 657 661 730 732 731 733.0 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JUZA Q8IVT5 601 881 923.0 ANP:901 ATPlike Pseudo DFGin 5.2511 13.1443 BLBplus -120.58, 157.85 65.97, 36.71 -81.68, 149.84 60.82, 87.44 61.36, 0.32 out-none out 13.842 Saltbr-none 999.0 HRD-in -63.05, -49.06 69.65, 1.96 none-out-out SNCnoo out-out ActLoopNT-out 6.9627 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -71.77, -43.35 APE9-dihe-na -54.66, -39.8 APE8-dihe-out -69.49, -39.39 APE8-rot-na 184.11 APE67-dihe-in -64.95, -32.88 -59.75, -32.59 APE12-dist-out 17.5733 APE11-dist-out 16.4181 APE10-dist-out 20.8305 APE9-dist-out 12.5923 None None None XRAY 3.21 0.255 0.272 A 334.0 273.0 8 33 25 8 [[613, 879]] 1.0 7juz Homo sapiens TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2.0 267.0 266.0 749 750 751 753 755 639 657 661 730 732 731 733.0 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JV0A Q8IVT5 601 881 923.0 ANP:901 ATPlike Pseudo DFGin 5.5443 13.2313 BLBplus -113.37, 179.62 53.84, 36.37 -87.67, 157.34 63.1, 86.33 73.66, -16.65 out-none out 13.3345 Saltbr-none 999.0 HRD-in -63.7, -53.29 73.57, 2.92 none-out-out SNCnoo out-out ActLoopNT-out 7.0046 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -74.36, -44.01 APE9-dihe-na -53.64, -41.33 APE8-dihe-out -66.6, -51.73 APE8-rot-na 184.61 APE67-dihe-in -59.37, -29.99 -47.75, -40.44 APE12-dist-out 17.6316 APE11-dist-out 16.6587 APE10-dist-out 21.0828 APE9-dist-out 12.7813 None None None XRAY 3.63 0.247 0.26 A 334.0 276.0 5 33 28 5 [[613, 879]] 1.0 7jv0 Homo sapiens TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2.0 267.0 266.0 749 750 751 753 755 639 657 661 730 732 731 733.0 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JV1D Q8IVT5 600 881 923.0 ANP:901 ATPlike Pseudo DFGin 4.998 13.0281 BLBplus -130.92, 154.93 60.0, 40.35 -76.18, 155.67 58.85, 79.94 54.95, 12.06 out-none out 13.7859 Saltbr-none 999.0 HRD-out -81.07, 84.18 -62.62, 147.5 none-out-out SNCnoo out-out ActLoopNT-out 6.8084 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -83.95, -45.7 APE9-dihe-na -55.75, -29.37 APE8-dihe-out -76.69, -37.65 APE8-rot-na 188.09 APE67-dihe-in -60.65, -19.03 -62.72, -36.82 APE12-dist-out 17.4871 APE11-dist-out 16.3482 APE10-dist-out 20.8077 APE9-dist-out 14.1451 None None None XRAY 3.62 0.278 0.303 D 334.0 275.0 7 33 26 7 [[613, 879]] 1.0 7jv1 Homo sapiens TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2.0 267.0 266.0 749 750 751 753 755 639 657 661 730 732 731 733.0 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR2 KSR2_HUMAN 7JURB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.5336 13.4444 BLBplus -136.74, 172.29 64.43, 21.01 -64.29, 145.08 51.43, 88.21 72.32, -17.93 out-none out 13.0577 Saltbr-none 999.0 HRD-in -74.46, -55.37 71.55, 3.38 none-out-out SNCnoo out-out ActLoopNT-out 7.6074 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -61.97, 131.45 APE9-dihe-na 84.3, -3.37 APE8-dihe-out -70.0, -57.71 APE8-rot-na 184.79 APE67-dihe-in -71.0, 1.52 -53.02, -42.72 APE12-dist-out 18.4829 APE11-dist-out 15.1355 APE10-dist-out 19.7424 APE9-dist-out 12.323 None None None XRAY 2.82 0.237 0.277 B 342.0 277.0 4 33 30 3 [[665, 930]] 1.0 7jur Homo sapiens TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2.0 267.0 266.0 802 803 804 806 808 692 710 714 783 785 784 786.0 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JUSB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.883 13.3826 BLBplus -127.91, 171.08 62.77, 22.74 -63.47, 150.27 47.2, 86.11 68.89, -21.25 out-none out 13.5127 Saltbr-none 999.0 HRD-in -73.66, -56.88 73.44, -2.22 none-out-out SNCnoo out-out ActLoopNT-out 7.5085 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -57.38, 137.79 APE9-dihe-na 90.37, -24.33 APE8-dihe-out -66.74, -57.02 APE8-rot-na 187.61 APE67-dihe-in -75.11, -1.38 -58.95, -34.29 APE12-dist-out 18.4212 APE11-dist-out 15.0772 APE10-dist-out 19.629 APE9-dist-out 12.0355 None None None XRAY 2.99 0.249 0.265 B 342.0 276.0 5 33 29 4 [[665, 930]] 1.0 7jus Homo sapiens TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2.0 267.0 266.0 802 803 804 806 808 692 710 714 783 785 784 786.0 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JUTB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.5556 12.9608 BLBplus -137.17, 153.82 70.92, 32.74 -74.86, 135.77 48.5, 88.18 74.13, -4.82 out-none out 14.2086 Saltbr-none 999.0 HRD-in -85.35, -39.03 46.26, 13.05 none-out-out SNCnoo out-out ActLoopNT-out 7.1963 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -53.57, -55.36 APE9-dihe-na -91.09, 3.18 APE8-dihe-out -71.8, -46.41 APE8-rot-na 181.21 APE67-dihe-in -68.18, -7.53 -62.86, -41.09 APE12-dist-out 18.1273 APE11-dist-out 15.4306 APE10-dist-out 19.5584 APE9-dist-out 11.9249 None None None XRAY 3.09 0.259 0.3 B 342.0 277.0 4 33 30 3 [[665, 930]] 1.0 7jut Homo sapiens TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2.0 267.0 266.0 802 803 804 806 808 692 710 714 783 785 784 786.0 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JUUB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.7734 13.2212 BLBplus -133.64, 151.36 70.73, 33.64 -75.25, 133.98 46.29, 83.15 80.08, -8.46 out-none out 14.4329 Saltbr-none 999.0 HRD-in -73.56, -47.69 67.59, 2.06 none-out-out SNCnoo out-out ActLoopNT-out 7.385 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -58.47, -51.54 APE9-dihe-na -86.76, 0.87 APE8-dihe-out -74.62, -44.43 APE8-rot-na 183.38 APE67-dihe-in -73.96, -6.37 -64.52, -36.97 APE12-dist-out 18.347 APE11-dist-out 15.5896 APE10-dist-out 19.7935 APE9-dist-out 12.0932 None None None XRAY 3.19 0.242 0.258 B 342.0 277.0 4 33 30 3 [[665, 930]] 1.0 7juu Homo sapiens TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2.0 267.0 266.0 802 803 804 806 808 692 710 714 783 785 784 786.0 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JUVB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.981 13.017 BLBplus -127.69, 170.94 63.29, 22.28 -64.16, 148.8 47.81, 86.58 68.48, -22.21 out-none out 13.6049 Saltbr-none 999.0 HRD-in -73.05, -56.86 73.65, -2.34 none-out-out SNCnoo out-out ActLoopNT-out 7.5025 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -57.84, 138.27 APE9-dihe-na 90.88, -24.23 APE8-dihe-out -67.14, -55.82 APE8-rot-na 188.73 APE67-dihe-in -75.46, -2.03 -58.92, -34.4 APE12-dist-out 18.2958 APE11-dist-out 15.1752 APE10-dist-out 19.8349 APE9-dist-out 12.1991 None None None XRAY 3.36 0.242 0.255 B 342.0 277.0 4 33 30 3 [[665, 930]] 1.0 7juv Homo sapiens TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2.0 267.0 266.0 802 803 804 806 808 692 710 714 783 785 784 786.0 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7UMBB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.5115 13.3329 BLBplus -122.69, -178.17 55.62, 31.28 -75.96, 141.02 47.41, 88.89 74.01, -10.38 out-none out 13.0769 Saltbr-none 999.0 HRD-in -83.2, -50.32 69.21, 5.46 none-out-out SNCnoo out-out ActLoopNT-out 7.5301 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -52.68, 124.31 APE9-dihe-na 106.73, -20.32 APE8-dihe-out -71.55, -49.08 APE8-rot-na 185.38 APE67-dihe-in -79.33, 2.43 -65.58, -32.18 APE12-dist-out 18.1185 APE11-dist-out 15.3981 APE10-dist-out 19.7231 APE9-dist-out 12.0091 None None None XRAY 3.231 0.231 0.268 B 342.0 277.0 4 33 30 3 [[665, 930]] 1.0 7umb Homo sapiens TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2.0 267.0 266.0 802 803 804 806 808 692 710 714 783 785 784 786.0 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL LIMK1 LIMK1_HUMAN 5HVJA P53667 329 633 647.0 ANP:1000 ATPlike Inactive DFGin 6.1667 14.0183 BLAminus -132.74, -177.4 60.53, 87.07 -109.1, 23.76 308.69, 90.48 -66.78, -25.98 in-in in 8.1192 Saltbr-in 2.7865 HRD-in -65.97, -50.93 68.53, 0.88 in-in-out SNCiio in-out ActLoopNT-in 2.9434 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oiio APE10-dihe-na -124.58, 95.6 APE9-dihe-na 76.06, -115.03 APE8-dihe-in -111.26, 122.06 APE8-rot-na 224.18 APE67-dihe-in -69.88, -30.27 -73.34, -10.37 APE12-dist-out 14.7577 APE11-dist-in 11.8135 APE10-dist-in 6.9252 APE9-dist-out 6.3724 D460N None None XRAY 2.2 0.208 0.252 A 315.0 283.0 22 42 20 22 [[339, 606]] 1.0 5hvj Homo sapiens TKL_LIMK1_HUMAN TKL 3e-76 262.4 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL LIMK1 LIMK1_HUMAN 5HVKA P53667 329 634 647.0 ANP:61001 ATPlike Active DFGin 6.4055 13.6462 BLAminus -145.46, 176.84 65.07, 82.49 -109.26, 24.73 304.62, 92.73 -71.79, -22.73 in-in in 7.7955 Saltbr-in 3.1595 HRD-in -70.8, -44.42 59.42, 18.52 in-in-in SNCiii in-in ActLoopNT-in 3.3239 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -139.63, 151.17 APE9-dihe-na 143.88, 171.7 APE8-dihe-in -71.51, 120.27 APE8-rot-na 199.31 APE67-dihe-in -66.59, -36.22 -54.03, -34.34 APE12-dist-in 9.3008 APE11-dist-in 11.0813 APE10-dist-in 5.6355 APE9-dist-in 3.574 D460N TPO508 TPO508 XRAY 3.5 0.275 0.31 A 315.0 293.0 13 42 29 13 [[339, 606]] 1.0 5hvk Homo sapiens TKL_LIMK1_HUMAN TKL 3e-76 262.4 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL LIMK1 LIMK1_HUMAN 5HVKC P53667 329 633 647.0 ANP:60701 ATPlike Inactive DFGin 6.0783 13.9339 None -149.69, 172.69 -101.87, 169.41 -110.21, 23.25 306.34, 92.8 -73.91, -25.16 in-out in 7.8911 Saltbr-out 3.6442 HRD-in -72.39, -44.63 59.79, 17.6 out-in-in SNCoii in-in ActLoopNT-in 3.0698 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -140.53, 148.22 APE9-dihe-na 140.89, 172.08 APE8-dihe-in -72.12, 119.75 APE8-rot-na 199.66 APE67-dihe-in -64.48, -35.33 -54.5, -33.22 APE12-dist-in 8.6689 APE11-dist-in 11.1988 APE10-dist-in 5.8992 APE9-dist-in 3.5423 D460N TPO508 TPO508 XRAY 3.5 0.275 0.31 C 315.0 291.0 14 42 28 14 [[339, 606]] 1.0 5hvk Homo sapiens TKL_LIMK1_HUMAN TKL 3e-76 262.4 3.0 266.0 264.0 477 478 479 481 483 368 384 388 457 459 458 460.0 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL LRRK2 LRRK2_HUMAN 8VH5A Q5S007 12 2527 2527.0 ANP:2602 ATPlike Inactive DFGinter 9.7464 8.455 None -88.01, 106.84 -81.35, 17.64 -78.83, -10.5 197.42, 64.93 -68.71, -22.79 out-out out 11.3256 Saltbr-out 8.1229 HRD-in -105.05, -49.61 72.56, -5.72 out-out-out SNCooo out-out ActLoopNT-out 8.9614 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -67.06, -23.38 APE9-dihe-na 73.72, 168.0 APE8-dihe-in -68.8, 143.98 APE8-rot-out 58.99 APE67-dihe-in -65.74, -54.3 -73.05, -29.17 APE12-dist-in 9.6328 APE11-dist-in 8.4163 APE10-dist-out 13.3438 APE9-dist-in 3.8609 None None None EM 4.0 999.0 999.0 A 2527.0 2221.0 8 26 18 8 [[1875, 2134]] 1.0 8vh5 Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8VH5C Q5S007 12 2527 2527.0 ANP:2602 ATPlike Inactive DFGinter 9.746 8.4552 None -88.01, 106.86 -81.36, 17.7 -78.84, -10.6 197.4, 64.92 -68.66, -22.76 out-out out 11.3253 Saltbr-out 8.1217 HRD-in -104.99, -49.63 72.52, -5.67 out-out-out SNCooo out-out ActLoopNT-out 8.9613 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -66.98, -23.42 APE9-dihe-na 73.64, 168.02 APE8-dihe-in -68.73, 143.93 APE8-rot-out 59.0 APE67-dihe-in -65.76, -54.24 -73.07, -29.13 APE12-dist-in 9.6328 APE11-dist-in 8.4176 APE10-dist-out 13.3446 APE9-dist-in 3.8618 None None None EM 4.0 999.0 999.0 C 2527.0 2221.0 8 26 18 8 [[1875, 2134]] 1.0 8vh5 Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8VH4A Q5S007 12 2527 2527.0 ANP:2602 ATPlike Inactive None 999.0 999.0 None -94.14, 87.28 -74.17, 5.0 -60.35, -20.37 999.0, 999.0 -59.12, -33.8 out-none out 12.056 Saltbr-none 999.0 HRD-in -102.88, -51.08 73.15, -5.33 none-out-out SNCnoo out-out ActLoopNT-out 8.7502 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -76.21, -33.07 APE9-dihe-na 74.7, 171.21 APE8-dihe-in -59.82, 149.42 APE8-rot-out 184.58 APE67-dihe-in -66.4, -59.35 -67.96, -43.48 APE12-dist-in 10.2221 APE11-dist-in 9.4484 APE10-dist-out 13.4907 APE9-dist-in 4.0567 None None None EM 4.1 999.0 999.0 A 2527.0 2235.0 8 26 18 8 [[1875, 2134]] 1.0 8vh4 Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL RAF1 RAF1_HUMAN 9AY7A P04049 343 612 648.0 ANP:701 ATPlike Inactive DFGin 5.8053 13.462 BLBplus -133.55, 174.37 58.47, 38.44 -90.49, 142.18 44.05, 90.72 78.29, -134.9 out-out out 14.0699 Saltbr-out 12.7376 HRD-in -73.02, -44.7 76.86, -25.12 out-out-out SNCooo out-out ActLoopNT-out 9.1822 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -145.48, 130.61 APE9-dihe-na 129.03, -169.57 APE8-dihe-in -79.63, 137.79 APE8-rot-in 302.79 APE67-dihe-in -63.4, -34.24 -69.33, -38.68 APE12-dist-out 15.2361 APE11-dist-out 15.0562 APE10-dist-out 10.6236 APE9-dist-out 6.3059 Y340D,Y341D None None XRAY 2.41 0.203 0.236 A 280.0 260.0 10 30 24 6 [[349, 608]] 1.0 9ay7 Homo sapiens TKL_RAF1_HUMAN TKL 2.6e-81 279.0 3.0 266.0 264.0 485 486 487 489 491 375 393 397 465 467 466 468.0 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
TKL TGFBR2 TGFR2_HUMAN 5E92A P37173 240 543 567.0 ANP:601 ATPlike Active DFGin 7.3963 13.3025 BLAminus -134.93, 178.1 63.07, 87.04 -105.26, 16.76 300.78, 96.96 -60.58, -26.14 in-in in 7.67 Saltbr-in 2.7517 HRD-in -64.87, -46.8 71.14, -4.53 in-in-in SNCiii in-in ActLoopNT-in 2.9815 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.21, 144.17 APE9-dihe-na 126.96, -149.92 APE8-dihe-in -116.55, 119.38 APE8-rot-in 300.41 APE67-dihe-in -54.91, -33.03 -42.96, -45.47 APE12-dist-in 11.7882 APE11-dist-in 12.049 APE10-dist-in 6.0891 APE9-dist-in 3.4015 E431A,R433A,E485A,K488A,R493A,R495A None None XRAY 2.08 0.204 0.231 A 316.0 298.0 6 32 32 0 [[244, 540]] 1.0 5e92 Homo sapiens TKL_TGFBR2_HUMAN TKL 1.9e-77 266.3 2.0 266.0 265.0 396 397 398 400 402 277 290 294 376 378 377 379.0 446 428 423 422 421 420 419 418 417 326 TGF-beta receptor type-2
TYR EGFR EGFR_HUMAN 3VJNA P00533 697 1018 1210.0 ANP:2001 ATPlike Inactive DFGin 6.0696 15.5531 BLAminus -140.47, -172.56 66.89, 81.42 -96.27, 22.36 285.26, 99.8 -61.68, -24.37 in-out in 8.8641 Saltbr-out 4.1594 HRD-in -62.92, -47.49 66.12, 0.14 out-in-in SNCoii in-in ActLoopNT-in 2.9023 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.98, 116.83 APE9-dihe-in -113.71, 140.82 APE8-dihe-in -56.67, 106.47 APE8-rot-na 28.1 APE67-dihe-in -67.09, -6.37 -61.28, -43.59 APE12-dist-na 11.7786 APE11-dist-na 9.7482 APE10-dist-na 10.9834 APE9-dist-in 5.9878 G719S,T790M None None XRAY 2.34 0.197 0.244 A 334.0 297.0 4 30 30 0 [[712, 970]] 1.0 3vjn Homo sapiens TYR_EGFR_HUMAN TYR 7.9e-87 296.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8DSWA P00533 696 1017 1210.0 ANP:61104 ATPlike None DFGin 5.9264 15.8583 BLAminus -139.88, -174.48 62.3, 80.03 -97.39, 21.12 300.26, 86.52 -53.52, -37.16 none-none none 999.0 Saltbr-none 999.0 HRD-in -81.01, -46.59 69.43, -1.39 none-in-none SNCnin in-none ActLoopNT-in 2.9212 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 105.32 APE8-dihe-in -90.45, 95.73 APE8-rot-na 32.83 APE67-dihe-in -75.5, -1.32 -70.5, -35.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.2191 None None None XRAY 2.39 0.197 0.246 A 335.0 301.0 12 30 21 9 [[712, 970]] 1.0 8dsw Homo sapiens TYR_EGFR_HUMAN TYR 1.9e-85 292.3 3.0 259.0 257.0 854 855 856 858 860 745 -9999 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITXA P00533 697 1019 1210.0 ANP:2020 ATPlike Active DFGin 5.8743 15.7373 BLAminus -136.31, -171.94 65.34, 93.22 -111.54, 18.75 298.27, 92.75 -59.44, 2.06 in-in in 9.2412 Saltbr-in 3.5833 HRD-in -62.41, -44.72 61.37, 7.79 in-in-in SNCiii in-in ActLoopNT-in 2.6419 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.73, 124.39 APE9-dihe-in -125.4, 144.12 APE8-dihe-in -79.64, 94.32 APE8-rot-na 30.37 APE67-dihe-in -65.37, -0.17 -61.69, -47.61 APE12-dist-na 11.888 APE11-dist-na 10.1512 APE10-dist-na 11.1341 APE9-dist-in 7.0583 None None None XRAY 2.98 0.191 0.261 A 327.0 307.0 4 30 26 4 [[712, 970]] 1.0 2itx Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3VJOA P00533 696 1018 1210.0 ANP:2001 ATPlike Inactive DFGin 6.0205 15.9464 BLAminus -140.25, -165.5 56.51, 77.02 -90.26, 19.04 285.97, 94.98 -60.96, -7.67 in-out in 9.402 Saltbr-out 4.5501 HRD-in -69.17, -43.62 63.06, 0.57 out-in-in SNCoii in-in ActLoopNT-in 2.9208 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.49, 106.7 APE9-dihe-in -122.63, 146.56 APE8-dihe-in -79.91, 93.84 APE8-rot-na 34.61 APE67-dihe-in -67.26, -9.93 -59.74, -34.59 APE12-dist-na 12.246 APE11-dist-na 10.097 APE10-dist-na 10.7621 APE9-dist-in 6.7711 None None None XRAY 2.64 0.19 0.228 A 334.0 298.0 5 30 30 0 [[712, 970]] 1.0 3vjo Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITNA P00533 696 1019 1210.0 ANP:2021 ATPlike None DFGin 6.2826 15.2349 BLAminus -127.19, -173.38 63.95, 79.84 -96.65, 10.56 295.4, 91.5 -73.87, 28.38 in-in in 8.2744 Saltbr-in 3.4075 HRD-in -81.37, -44.82 70.79, -0.2 in-in-none SNCiin in-none ActLoopNT-in 2.8429 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 98.73 APE8-dihe-in -79.18, 91.37 APE8-rot-na 30.4 APE67-dihe-in -69.96, -4.57 -72.15, -41.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6741 G719S None None XRAY 2.47 0.201 0.267 A 327.0 304.0 9 30 21 9 [[712, 970]] 1.0 2itn Homo sapiens TYR_EGFR_HUMAN TYR 9.6e-87 296.6 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITVA P00533 696 1019 1210.0 ANP:2020 ATPlike None DFGin 6.2164 15.481 BLAminus -132.41, -173.63 61.69, 81.35 -94.21, 13.19 293.51, 90.37 -58.84, 7.8 in-in in 8.5836 Saltbr-in 3.4621 HRD-in -75.87, -46.5 68.4, 1.6 in-in-none SNCiin in-none ActLoopNT-in 2.7367 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.23 APE8-dihe-in -83.21, 92.63 APE8-rot-na 31.24 APE67-dihe-in -66.41, -6.91 -75.93, -39.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5693 L858R None None XRAY 2.47 0.197 0.242 A 327.0 303.0 9 30 21 9 [[712, 970]] 1.0 2itv Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2EB3A P00533 696 1018 1210.0 ANP:2001 ATPlike Inactive DFGin 4.6656 14.8692 BLAplus -146.31, -170.86 55.73, 31.55 -96.53, 44.19 45.64, 108.62 -72.56, -59.05 in-in in 8.5938 Saltbr-in 3.4427 HRD-out -53.85, 138.27 -123.62, 23.93 in-in-none SNCiin in-none ActLoopNT-in 2.5854 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 154.55 APE8-dihe-in -88.38, 74.74 APE8-rot-na 41.16 APE67-dihe-in -67.41, -11.07 -62.2, -31.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8933 None None None XRAY 2.84 0.19 0.236 A 334.0 294.0 15 30 16 14 [[712, 970]] 1.0 2eb3 Homo sapiens TYR_EGFR_HUMAN TYR 1.2e-86 296.3 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1LB P00533 702 1008 1210.0 ANP:1102 ATPlike Inactive DFGin 4.3261 15.4771 BLBplus -134.87, 177.11 52.28, 41.66 -92.52, 151.37 118.41, 82.73 79.24, 7.39 out-out out 13.7513 Saltbr-out 14.7662 HRD-in -69.63, -50.82 67.27, 3.74 out-out-out SNCooo out-out ActLoopNT-out 8.6943 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -67.98 APE8-dihe-in -90.55, 79.54 APE8-rot-na 36.74 APE67-dihe-in -76.92, -3.19 -66.82, -38.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.3817 T790M,V948R None None XRAY 2.8 0.203 0.237 B 327.0 292.0 15 30 15 15 [[712, 970]] 1.0 6p1l Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6WAKA P00533 702 1013 1210.0 ANP:1101 ATPlike Inactive DFGin 3.6796 14.038 BLBplus -119.87, 174.58 64.54, 16.96 -69.25, 144.86 73.85, 86.13 77.2, -6.44 out-out out 14.1902 Saltbr-out 14.8704 HRD-in -68.06, -64.5 89.93, -15.8 out-out-out SNCooo out-out ActLoopNT-out 6.0562 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -95.75, -0.13 APE9-dihe-in -104.56, 101.78 APE8-dihe-in -62.85, 69.07 APE8-rot-na 27.65 APE67-dihe-in -73.63, -8.28 -54.79, -35.95 APE12-dist-na 999.0 APE11-dist-na 15.6242 APE10-dist-na 11.3401 APE9-dist-in 7.7723 T790M,V948R None None XRAY 2.4 0.219 0.23 A 328.0 297.0 10 30 20 10 [[712, 970]] 1.0 6wak Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6WAKD P00533 701 1014 1210.0 ANP:1101 ATPlike Inactive DFGin 3.8807 14.6672 BLBplus -128.56, 164.59 71.9, 35.94 -89.47, 146.64 77.53, 95.38 87.93, -24.37 out-out out 13.7529 Saltbr-out 11.845 HRD-in -75.5, -62.2 82.94, 0.35 out-out-out SNCooo out-out ActLoopNT-out 6.735 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.69 APE8-dihe-in -82.11, 67.25 APE8-rot-na 35.47 APE67-dihe-in -67.78, -4.44 -51.76, -45.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.0459 T790M,V948R None None XRAY 2.4 0.219 0.23 D 328.0 297.0 17 30 16 14 [[712, 970]] 1.0 6wak Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8FV3A P00533 701 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 3.9601 13.3971 BLBplus -132.16, 169.96 65.72, 32.0 -78.17, 140.3 56.84, 82.43 67.0, 6.27 out-out out 13.5436 Saltbr-out 14.7322 HRD-in -69.71, -62.71 86.1, -12.85 out-out-none SNCoon out-none ActLoopNT-out 6.5423 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 27.23 APE9-dihe-in -63.25, 122.03 APE8-dihe-in -75.98, 67.82 APE8-rot-na 29.66 APE67-dihe-in -76.37, -3.74 -56.38, -36.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.7262 APE9-dist-in 7.9867 T790M,V948R None None XRAY 2.1 0.191 0.226 A 328.0 299.0 14 30 18 12 [[712, 970]] 1.0 8fv3 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8FV4C P00533 702 1013 1210.0 ANP:1102 ATPlike Inactive DFGin 4.0815 13.5578 BLBplus -127.73, 168.23 73.07, 11.78 -61.24, 145.82 61.45, 98.91 81.41, -31.2 out-out out 13.7417 Saltbr-out 16.1154 HRD-in -67.13, -63.64 88.26, -13.01 out-out-out SNCooo out-out ActLoopNT-out 6.5839 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -45.21, -49.43 APE9-dihe-in -74.91, 126.99 APE8-dihe-in -76.17, 58.7 APE8-rot-na 28.97 APE67-dihe-in -74.88, -4.9 -52.62, -40.92 APE12-dist-na 999.0 APE11-dist-na 16.2617 APE10-dist-na 12.2316 APE9-dist-out 8.1002 T790M,V948R None None XRAY 2.2 0.204 0.261 C 328.0 296.0 11 30 19 11 [[712, 970]] 1.0 8fv4 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO3B P00533 702 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 3.6573 14.9344 BLBplus -134.55, 162.66 68.08, 49.36 -93.73, 164.43 101.15, 105.54 56.1, 2.84 out-out out 13.7673 Saltbr-out 13.9706 HRD-in -68.15, -46.1 73.95, -11.19 out-out-out SNCooo out-out ActLoopNT-out 6.8421 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 106.24 APE8-dihe-in -74.12, 71.61 APE8-rot-na 27.49 APE67-dihe-in -65.2, -1.6 -53.66, -41.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1295 T790M,V948R None None XRAY 2.49 0.231 0.269 B 328.0 291.0 18 30 17 13 [[712, 970]] 1.0 8to3 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO4B P00533 702 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 4.3212 13.8382 BLBplus -145.22, 172.21 45.08, 44.37 -91.4, 153.78 67.05, 82.38 64.94, 7.17 out-out out 14.0112 Saltbr-out 13.4798 HRD-in -63.39, -70.27 96.97, -15.43 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.51 APE8-dihe-in -77.84, 67.96 APE8-rot-na 10.85 APE67-dihe-in -65.93, -24.75 -51.27, -47.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5367 T790M,V948R None None XRAY 2.99 0.176 0.231 B 328.0 290.0 18 30 16 14 [[712, 970]] 1.0 8to4 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4ZSED P00533 701 1015 1210.0 ANP:4001 ATPlike Inactive DFGin 4.4807 13.6994 BLBplus -139.61, 164.7 66.53, 26.19 -71.23, 138.48 53.66, 91.47 74.43, 7.23 out-out out 13.877 Saltbr-out 13.6856 HRD-in -70.41, -53.51 80.03, -13.83 out-out-none SNCoon out-none ActLoopNT-out 6.5216 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.0 APE8-dihe-in -83.67, 68.18 APE8-rot-na 28.71 APE67-dihe-in -64.05, -23.47 -60.9, -39.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.9891 T790M,V948R None None XRAY 1.97 0.191 0.213 D 331.0 297.0 14 30 18 12 [[712, 970]] 1.0 4zse Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5D41B P00533 701 1014 1210.0 ANP:2001 ATPlike Inactive DFGin 3.9465 14.2825 BLBplus -122.59, 173.39 56.77, 40.3 -84.43, 150.38 61.52, 86.97 79.88, -36.14 out-out out 13.6662 Saltbr-out 11.1436 HRD-in -72.27, -56.38 80.95, -10.72 out-out-out SNCooo out-out ActLoopNT-out 6.673 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -30.97 APE9-dihe-in -100.3, 124.18 APE8-dihe-in -72.86, 61.7 APE8-rot-na 30.04 APE67-dihe-in -79.76, 0.67 -51.2, -39.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.5009 APE9-dist-out 8.3525 T790M,V948R None None XRAY 2.31 0.175 0.207 B 331.0 302.0 12 30 18 12 [[712, 970]] 1.0 5d41 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5X2AD P00533 701 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 4.5667 13.491 BLBplus -132.47, 164.02 73.22, 18.47 -66.23, 142.03 48.39, 91.71 77.4, 1.26 out-out out 13.9917 Saltbr-out 14.3497 HRD-in -72.94, -56.49 82.37, -10.91 out-out-out SNCooo out-out ActLoopNT-out 6.4634 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 3.06 APE9-dihe-in -69.62, 129.82 APE8-dihe-in -83.4, 65.28 APE8-rot-na 22.72 APE67-dihe-in -72.49, -3.02 -53.67, -40.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.8971 APE9-dist-out 8.2345 T790M,V948R None None XRAY 1.85 0.176 0.219 D 331.0 297.0 13 30 20 10 [[712, 970]] 1.0 5x2a Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXKB P00533 700 1007 1210.0 ANP:1101 ATPlike Inactive DFGin 4.788 14.3042 BLBplus -133.99, 169.66 58.32, 39.23 -93.88, 160.42 49.41, 87.38 74.89, 999.0 out-out out 13.4903 Saltbr-out 12.3941 HRD-in -66.37, -58.14 81.2, -5.32 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.52 APE8-dihe-in -80.54, 72.01 APE8-rot-na 30.24 APE67-dihe-in -73.85, -4.26 -53.45, -45.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5412 T790M,V948R None None XRAY 3.1 0.223 0.261 B 331.0 290.0 18 30 12 18 [[712, 970]] 1.0 7jxk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXMC P00533 702 1006 1210.0 ANP:1101 ATPlike Inactive DFGin 4.2828 13.994 BLBplus -133.09, 168.24 59.36, 33.1 -80.78, 143.72 58.15, 87.09 66.36, 74.02 out-out out 13.9625 Saltbr-out 13.1185 HRD-in -67.9, -61.75 83.53, -6.82 out-out-none SNCoon out-none ActLoopNT-out 9.0085 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.47 APE8-dihe-in -77.6, 66.96 APE8-rot-na 35.92 APE67-dihe-in -75.2, -5.27 -47.14, -42.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.517 T790M,V948R None None XRAY 2.192 0.228 0.271 C 331.0 285.0 20 30 15 15 [[712, 970]] 1.0 7jxm Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CNOB P00533 698 1015 1210.0 ANP:61001 ATPlike Inactive DFGin 3.8893 14.1511 BLBplus -128.77, 161.65 68.19, 38.17 -78.09, 143.32 56.13, 92.23 54.89, 36.11 out-out out 13.8774 Saltbr-out 12.6073 HRD-in -79.53, -48.18 74.57, -9.86 out-out-out SNCooo out-out ActLoopNT-out 8.1881 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 114.62 APE9-dihe-in -83.89, 124.6 APE8-dihe-in -81.17, 61.86 APE8-rot-na 30.73 APE67-dihe-in -73.98, -7.26 -47.13, -40.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.0922 APE9-dist-out 8.4007 V948R None None XRAY 1.55 0.176 0.203 B 330.0 302.0 16 30 18 12 [[712, 970]] 1.0 5cno Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CNNA P00533 699 1014 1210.0 ANP:61101 ATPlike Inactive DFGin 3.9697 14.1701 BLBplus -125.09, 165.12 65.79, 30.65 -73.26, 142.49 57.23, 92.2 61.04, 28.88 out-out out 14.4189 Saltbr-out 11.3969 HRD-in -77.1, -52.71 74.61, -9.55 out-out-none SNCoon out-none ActLoopNT-out 8.169 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 61.56 APE9-dihe-in -85.48, 136.67 APE8-dihe-in -75.32, 67.13 APE8-rot-na 28.89 APE67-dihe-in -79.02, -2.66 -49.07, -38.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.9974 APE9-dist-in 7.9937 I706Q None None XRAY 1.9 0.183 0.211 A 350.0 300.0 16 30 17 13 [[712, 970]] 1.0 5cnn Homo sapiens TYR_EGFR_HUMAN TYR 1.3e-87 299.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1DB P00533 702 1013 1210.0 ANP:1101,NQ1:1102 ATPlike,Type3 Inactive DFGin 4.7371 14.0299 BLBplus -133.29, 171.5 64.7, 17.77 -68.3, 145.06 52.12, 92.58 81.65, -14.38 out-out out 13.7895 Saltbr-out 14.416 HRD-in -75.11, -58.04 81.02, -12.96 out-out-out SNCooo out-out ActLoopNT-out 6.3903 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -53.71 APE8-dihe-in -78.39, 61.97 APE8-rot-na 34.06 APE67-dihe-in -73.46, -6.67 -54.96, -43.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.3559 None None None XRAY 2.4 0.195 0.213 B 327.0 300.0 12 30 18 12 [[712, 970]] 1.0 6p1d Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1LA P00533 701 1007 1210.0 ANP:1102,9LL:1103 ATPlike,Type3 Inactive DFGin 5.0904 14.6089 BLBplus -137.99, 174.26 51.86, 38.49 -97.68, 160.33 56.12, 79.32 80.95, 13.49 out-out out 13.0903 Saltbr-out 11.075 HRD-in -66.81, -53.87 69.64, 3.15 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.91 APE8-dihe-in -92.34, 76.37 APE8-rot-na 35.99 APE67-dihe-in -76.25, -4.78 -68.05, -35.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.3608 T790M,V948R None None XRAY 2.8 0.203 0.237 A 327.0 288.0 19 30 13 17 [[712, 970]] 1.0 6p1l Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1LC P00533 702 1005 1210.0 ANP:1102,9LL:1103 ATPlike,Type3 Inactive DFGin 4.9465 14.3459 BLBplus -138.12, 175.57 52.19, 39.44 -97.35, 162.11 56.76, 79.57 81.63, 13.51 out-out out 13.0686 Saltbr-out 12.6895 HRD-in -65.46, -53.47 68.76, 3.35 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -21.1 APE8-dihe-in -91.14, 76.85 APE8-rot-na 36.16 APE67-dihe-in -74.42, -4.16 -69.53, -34.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.035 T790M,V948R None None XRAY 2.8 0.203 0.237 C 327.0 280.0 24 30 13 17 [[712, 970]] 1.0 6p1l Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1LD P00533 702 1015 1210.0 ANP:1102,9LL:1103 ATPlike,Type3 Inactive DFGin 5.1933 14.6343 BLBplus -136.45, 175.46 51.75, 39.49 -96.95, 158.96 56.24, 81.53 81.72, 11.0 out-out out 13.1546 Saltbr-out 10.9823 HRD-in -66.43, -53.42 65.79, 5.44 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.86 APE8-dihe-in -92.75, 77.55 APE8-rot-na 35.81 APE67-dihe-in -75.19, -4.23 -67.58, -35.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.0944 T790M,V948R None None XRAY 2.8 0.203 0.237 D 327.0 296.0 17 30 13 17 [[712, 970]] 1.0 6p1l Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P8QA P00533 699 1019 1210.0 ANP:2001,O57:2002 ATPlike,Type3 Inactive DFGin 5.2914 14.4671 BLBplus -136.39, 166.39 65.62, 19.67 -68.64, 141.86 47.45, 96.29 88.91, -15.41 out-out out 13.7934 Saltbr-out 13.3942 HRD-in -77.48, -60.3 86.7, -15.68 out-out-none SNCoon out-none ActLoopNT-out 6.9269 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 121.69 APE8-dihe-in -82.28, 70.48 APE8-rot-na 31.78 APE67-dihe-in -69.54, -10.7 -59.7, -40.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5228 T790M,V948R None None XRAY 1.9 0.169 0.195 A 327.0 309.0 12 30 18 12 [[712, 970]] 1.0 6p8q Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6XL4D P00533 700 1013 1210.0 ANP:1102,NQ1:1103 ATPlike,Type3 Inactive DFGin 4.8901 14.2469 BLBplus -133.2, 175.82 65.76, 18.85 -77.15, 145.6 52.8, 92.59 74.56, -2.19 out-out out 13.6236 Saltbr-out 15.8297 HRD-in -71.69, -57.79 76.59, -4.88 out-out-none SNCoon out-none ActLoopNT-out 6.4776 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.17 APE8-dihe-in -78.79, 71.74 APE8-rot-na 31.74 APE67-dihe-in -74.38, -1.99 -55.71, -41.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.7702 T790M,V948R None None XRAY 2.06 0.216 0.252 D 328.0 300.0 14 30 19 11 [[712, 970]] 1.0 6xl4 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO4C P00533 702 1013 1210.0 ANP:1102,IXR:1103 ATPlike,Type3 Inactive DFGin 5.3236 14.7029 BLBplus -141.27, 171.12 64.77, 53.38 -109.59, 167.64 42.74, 100.72 59.4, 999.0 out-out out 13.2945 Saltbr-out 12.3497 HRD-in -63.29, -59.94 84.01, 4.45 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.05 APE8-dihe-in -90.09, 61.93 APE8-rot-na 21.85 APE67-dihe-in -81.47, -6.07 -53.96, -24.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8359 T790M,V948R None None XRAY 2.99 0.176 0.231 C 328.0 289.0 18 30 12 18 [[712, 970]] 1.0 8to4 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO4D P00533 702 1005 1210.0 ANP:1102,IXR:1103 ATPlike,Type3 Inactive DFGin 4.5511 14.1875 BLBplus -127.27, 157.13 78.08, 44.22 -85.23, -172.29 38.08, 100.01 106.69, 999.0 out-out out 13.6561 Saltbr-out 10.8245 HRD-in -72.87, -44.75 69.45, -7.84 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 105.73 APE8-dihe-in -81.92, 60.79 APE8-rot-na 34.7 APE67-dihe-in -66.67, -11.33 -39.66, -48.35 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6599 T790M,V948R None None XRAY 2.99 0.176 0.231 D 328.0 283.0 20 30 12 18 [[712, 970]] 1.0 8to4 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5D41A P00533 698 1014 1210.0 ANP:1102,57N:1103 ATPlike,Type3 Inactive DFGin 4.968 14.448 BLBplus -130.27, 169.23 61.95, 37.88 -93.29, 173.71 50.74, 86.35 79.65, -10.55 out-out out 12.815 Saltbr-out 11.3738 HRD-in -77.25, -55.76 78.51, -14.31 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 155.57 APE8-dihe-in -80.12, 74.82 APE8-rot-na 31.53 APE67-dihe-in -75.45, -3.11 -51.46, -43.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8002 T790M,V948R None None XRAY 2.31 0.175 0.207 A 331.0 300.0 17 30 13 17 [[712, 970]] 1.0 5d41 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6DUKA P00533 701 1006 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.4162 14.8008 BLBplus -133.89, 165.03 66.94, 37.08 -93.36, 166.29 58.42, 86.37 91.91, 6.11 out-out out 13.9176 Saltbr-out 14.1793 HRD-in -76.73, -64.87 85.37, -18.97 out-out-out SNCooo out-out ActLoopNT-out 7.4382 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.39, -10.84 APE9-dihe-in -125.5, 116.79 APE8-dihe-in -80.16, 76.04 APE8-rot-na 31.69 APE67-dihe-in -76.14, -1.34 -58.18, -44.83 APE12-dist-na 17.3641 APE11-dist-na 15.2023 APE10-dist-na 11.7763 APE9-dist-in 7.3106 T790M,V948R None None XRAY 2.2 0.191 0.223 A 331.0 306.0 0 30 30 0 [[712, 970]] 1.0 6duk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6DUKB P00533 699 1007 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.6806 14.6502 BLBplus -136.44, 165.42 61.83, 36.22 -89.54, 161.73 53.44, 89.67 90.48, 19.39 out-out out 13.8125 Saltbr-out 14.7331 HRD-in -68.48, -61.78 82.94, -15.18 out-out-none SNCoon out-none ActLoopNT-out 7.2922 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.53 APE8-dihe-in -76.17, 63.91 APE8-rot-na 26.99 APE67-dihe-in -79.83, -2.27 -51.77, -41.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.9222 T790M,V948R None None XRAY 2.2 0.191 0.223 B 331.0 296.0 13 30 17 13 [[712, 970]] 1.0 6duk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6DUKC P00533 699 1007 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.6614 14.3909 BLBplus -137.36, 170.05 61.14, 32.95 -87.42, 165.36 52.89, 84.68 86.51, 15.0 out-out out 13.7494 Saltbr-out 12.3873 HRD-in -66.04, -61.2 80.35, -9.27 out-out-none SNCoon out-none ActLoopNT-out 8.2862 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 116.92 APE8-dihe-in -77.64, 67.39 APE8-rot-na 32.93 APE67-dihe-in -71.69, -8.16 -55.72, -42.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8229 T790M,V948R None None XRAY 2.2 0.191 0.223 C 331.0 295.0 14 30 16 14 [[712, 970]] 1.0 6duk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6DUKD P00533 701 1007 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.6052 14.6344 BLBplus -137.83, 165.45 65.63, 29.61 -82.3, 167.28 56.12, 84.13 94.16, 13.47 out-out out 14.053 Saltbr-out 14.8858 HRD-in -74.03, -57.71 81.46, -18.53 out-out-out SNCooo out-out ActLoopNT-out 7.3207 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -76.03, 11.31 APE9-dihe-in -134.89, 121.24 APE8-dihe-in -86.59, 77.19 APE8-rot-na 34.21 APE67-dihe-in -72.84, -7.51 -59.65, -43.13 APE12-dist-na 17.7472 APE11-dist-na 15.5553 APE10-dist-na 11.9033 APE9-dist-in 7.5388 T790M,V948R None None XRAY 2.2 0.191 0.223 D 331.0 307.0 0 30 30 0 [[712, 970]] 1.0 6duk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6DUKE P00533 698 1007 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.7057 14.387 BLBplus -132.31, 167.27 63.11, 42.82 -102.17, 159.55 52.62, 85.09 88.84, 16.78 out-out out 13.7684 Saltbr-out 14.3613 HRD-in -70.33, -59.21 85.76, -23.74 out-out-none SNCoon out-none ActLoopNT-out 7.6865 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 1.83 APE9-dihe-in -127.74, 112.92 APE8-dihe-in -68.38, 64.27 APE8-rot-na 21.48 APE67-dihe-in -73.72, -8.33 -52.7, -41.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.2913 APE9-dist-in 7.9406 T790M,V948R None None XRAY 2.2 0.191 0.223 E 331.0 298.0 12 30 18 12 [[712, 970]] 1.0 6duk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6DUKF P00533 701 1009 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.6528 14.6121 BLBplus -133.82, 164.75 63.96, 32.85 -83.32, 163.7 53.83, 93.49 88.31, 19.42 out-out out 14.1084 Saltbr-out 15.1439 HRD-in -67.38, -62.37 88.35, -19.9 out-out-none SNCoon out-none ActLoopNT-out 7.3188 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.72 APE8-dihe-in -80.72, 70.63 APE8-rot-na 32.98 APE67-dihe-in -75.6, -2.87 -62.49, -36.24 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8407 T790M,V948R None None XRAY 2.2 0.191 0.223 F 331.0 298.0 11 30 19 11 [[712, 970]] 1.0 6duk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXKD P00533 700 1007 1210.0 ANP:1101,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.8614 14.45 BLBplus -134.29, 170.65 60.11, 37.92 -95.07, 160.21 48.8, 86.41 74.63, 26.88 out-out out 13.4574 Saltbr-out 11.7626 HRD-in -66.46, -59.56 80.54, -6.1 out-out-none SNCoon out-none ActLoopNT-out 8.9029 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.41 APE8-dihe-in -81.29, 71.57 APE8-rot-na 30.4 APE67-dihe-in -73.66, -4.05 -53.54, -44.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4718 T790M,V948R None None XRAY 3.1 0.223 0.261 D 331.0 294.0 14 30 16 14 [[712, 970]] 1.0 7jxk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXMD P00533 700 1007 1210.0 ANP:1101,9LL:1103 ATPlike,Type3 Inactive DFGin 4.9516 14.3368 BLBplus -135.28, 170.25 61.86, 31.57 -85.27, 155.14 53.77, 85.22 78.23, 19.31 out-out out 13.0485 Saltbr-out 11.8943 HRD-in -66.52, -63.02 84.71, -6.37 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.04 APE8-dihe-in -80.42, 66.88 APE8-rot-na 32.97 APE67-dihe-in -76.05, -3.45 -51.47, -42.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.762 T790M,V948R None None XRAY 2.192 0.228 0.271 D 331.0 291.0 17 30 13 17 [[712, 970]] 1.0 7jxm Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXPA P00533 700 1007 1210.0 ANP:1101,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.7467 14.6167 BLBplus -136.18, 166.76 64.66, 34.04 -92.53, 168.9 56.02, 85.41 85.63, 11.86 out-out out 13.9879 Saltbr-out 14.3068 HRD-in -74.54, -64.28 89.28, -17.63 out-out-out SNCooo out-out ActLoopNT-out 7.5088 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -97.63, -15.8 APE9-dihe-in -113.05, 126.54 APE8-dihe-in -83.29, 68.9 APE8-rot-na 33.94 APE67-dihe-in -74.36, -3.96 -52.3, -47.62 APE12-dist-na 17.0956 APE11-dist-na 14.9557 APE10-dist-na 11.6928 APE9-dist-in 7.4058 T790M,V948R None None XRAY 2.16 0.214 0.247 A 331.0 308.0 0 30 30 0 [[712, 970]] 1.0 7jxp Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXPB P00533 700 1007 1210.0 ANP:1101,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.6706 14.5109 BLBplus -135.21, 165.17 64.35, 37.85 -90.15, 169.17 53.82, 91.67 84.59, 7.68 out-out out 13.7558 Saltbr-out 13.8881 HRD-in -70.65, -63.17 87.36, -17.28 out-out-out SNCooo out-out ActLoopNT-out 7.5923 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -97.44, -17.16 APE9-dihe-in -126.66, 129.43 APE8-dihe-in -78.52, 67.74 APE8-rot-na 34.72 APE67-dihe-in -76.32, -3.64 -51.52, -45.13 APE12-dist-na 17.4376 APE11-dist-na 15.2142 APE10-dist-na 12.2746 APE9-dist-in 7.6166 T790M,V948R None None XRAY 2.16 0.214 0.247 B 331.0 308.0 0 30 30 0 [[712, 970]] 1.0 7jxp Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXPD P00533 700 1007 1210.0 ANP:1101,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.766 14.6606 BLBplus -135.69, 167.35 65.6, 33.96 -89.97, 168.72 55.6, 87.2 84.96, 9.82 out-out out 13.5259 Saltbr-out 11.2829 HRD-in -71.06, -65.03 87.13, -14.24 out-out-none SNCoon out-none ActLoopNT-out 8.0039 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.01 APE8-dihe-in -77.89, 69.26 APE8-rot-na 33.29 APE67-dihe-in -74.9, -2.69 -52.27, -42.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.7443 T790M,V948R None None XRAY 2.16 0.214 0.247 D 331.0 294.0 14 30 16 14 [[712, 970]] 1.0 7jxp Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXPF P00533 700 1007 1210.0 ANP:1101,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.9745 14.7024 BLBplus -136.82, 166.82 61.14, 36.57 -93.57, 171.83 53.4, 92.66 83.03, -0.51 out-out out 13.6744 Saltbr-out 11.5698 HRD-in -71.01, -63.71 87.17, -13.68 out-out-none SNCoon out-none ActLoopNT-out 9.118 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.33 APE8-dihe-in -78.62, 69.48 APE8-rot-na 32.72 APE67-dihe-in -72.69, -4.28 -52.16, -45.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6211 T790M,V948R None None XRAY 2.16 0.214 0.247 F 331.0 294.0 14 30 16 14 [[712, 970]] 1.0 7jxp Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXQB P00533 701 1007 1210.0 ANP:1102,VNS:1103 ATPlike,Type3 Inactive DFGin 4.9153 14.4376 BLBplus -136.8, 171.78 58.87, 35.86 -91.33, 162.29 51.51, 87.21 80.67, 16.0 out-out out 13.3352 Saltbr-out 12.6978 HRD-in -67.21, -58.71 77.88, -12.51 out-out-none SNCoon out-none ActLoopNT-out 8.8959 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -177.71 APE9-dihe-in -105.47, 135.84 APE8-dihe-in -83.2, 67.78 APE8-rot-na 33.37 APE67-dihe-in -74.22, -7.65 -49.73, -41.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.7343 APE9-dist-in 7.6451 T790M,V948R None None XRAY 1.83 0.185 0.218 B 331.0 297.0 10 30 20 10 [[712, 970]] 1.0 7jxq Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXQD P00533 700 1007 1210.0 ANP:1102,VNS:1103 ATPlike,Type3 Inactive DFGin 4.8444 14.3284 BLBplus -136.14, 172.56 58.98, 36.18 -92.84, 162.13 51.55, 88.05 79.36, 17.26 out-out out 13.4204 Saltbr-out 11.8902 HRD-in -65.12, -58.0 78.92, -12.53 out-out-none SNCoon out-none ActLoopNT-out 8.9401 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.09 APE8-dihe-in -80.19, 68.24 APE8-rot-na 33.29 APE67-dihe-in -74.77, -5.19 -50.69, -44.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5794 T790M,V948R None None XRAY 1.83 0.185 0.218 D 331.0 298.0 10 30 20 10 [[712, 970]] 1.0 7jxq Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7LTXA P00533 700 1007 1210.0 ANP:1101,YFA:1103 ATPlike,Type3 Inactive DFGin 5.2481 14.5643 BLBplus -135.35, 163.04 64.03, 33.94 -82.37, 179.4 48.16, 87.26 -162.42, -162.89 out-out out 13.1822 Saltbr-out 10.5993 HRD-in -67.02, -61.48 82.46, -5.8 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.93 APE8-dihe-in -80.94, 68.72 APE8-rot-na 31.43 APE67-dihe-in -70.18, -9.53 -51.9, -44.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.02 T790M,V948R None None XRAY 2.3 0.187 0.216 A 331.0 292.0 16 30 14 16 [[712, 970]] 1.0 7ltx Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7LTXB P00533 700 1007 1210.0 ANP:1101,YFA:1103 ATPlike,Type3 Inactive DFGin 5.1967 14.4947 BLBplus -136.17, 169.66 62.42, 34.77 -78.22, 170.05 42.44, 90.17 -152.16, -165.64 out-out out 13.123 Saltbr-out 10.2264 HRD-in -65.63, -61.11 82.51, -6.05 out-out-none SNCoon out-none ActLoopNT-out 9.2387 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.13 APE8-dihe-in -82.01, 66.41 APE8-rot-na 31.46 APE67-dihe-in -73.58, -7.26 -49.71, -42.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8286 T790M,V948R None None XRAY 2.3 0.187 0.216 B 331.0 293.0 15 30 15 15 [[712, 970]] 1.0 7ltx Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7LTXC P00533 700 1007 1210.0 ANP:1101,YFA:1103 ATPlike,Type3 Inactive DFGin 5.1227 14.5107 BLBplus -136.55, 165.71 63.6, 32.17 -87.45, 156.27 46.73, 94.27 148.1, 156.05 out-out out 13.0711 Saltbr-out 10.0756 HRD-in -65.09, -59.89 81.29, -6.26 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.8 APE8-dihe-in -79.63, 67.92 APE8-rot-na 31.3 APE67-dihe-in -72.94, -5.81 -52.93, -44.7 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8643 T790M,V948R None None XRAY 2.3 0.187 0.216 C 331.0 292.0 16 30 14 16 [[712, 970]] 1.0 7ltx Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7LTXD P00533 700 1007 1210.0 ANP:1101,YFA:1103 ATPlike,Type3 Inactive DFGin 5.3456 14.4432 BLBplus -137.08, 165.99 63.56, 34.05 -81.77, 167.16 44.82, 94.68 -177.57, 165.83 out-out out 12.9855 Saltbr-out 10.3401 HRD-in -68.33, -62.57 83.39, -4.99 out-out-none SNCoon out-none ActLoopNT-out 9.4938 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.9 APE8-dihe-in -80.86, 67.56 APE8-rot-na 30.12 APE67-dihe-in -73.23, -5.97 -50.49, -42.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.9168 T790M,V948R None None XRAY 2.3 0.187 0.216 D 331.0 293.0 15 30 15 15 [[712, 970]] 1.0 7ltx Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8GB4A P00533 700 1007 1210.0 ANP:1102,YW5:1103 ATPlike,Type3 Inactive DFGin 4.7378 14.7779 BLBplus -140.96, 174.92 57.37, 44.23 -99.53, 158.98 50.67, 86.24 74.62, 16.37 out-out out 13.3553 Saltbr-out 11.6982 HRD-in -69.91, -59.18 79.33, -9.52 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.01 APE8-dihe-in -76.27, 67.14 APE8-rot-na 30.24 APE67-dihe-in -75.65, -5.48 -58.37, -41.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.0578 T790M,V948R None None XRAY 2.59 0.23 0.254 A 331.0 292.0 16 30 14 16 [[712, 970]] 1.0 8gb4 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8GB4B P00533 700 1007 1210.0 ANP:1102,YW5:1103 ATPlike,Type3 Inactive DFGin 4.8583 14.6814 BLBplus -140.61, 174.15 57.09, 43.59 -100.33, 162.57 51.99, 86.76 77.41, 18.84 out-out out 13.39 Saltbr-out 10.5312 HRD-in -69.24, -58.17 79.24, -10.08 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.16 APE8-rot-na 30.06 APE67-dihe-in -75.09, -5.85 -58.81, -39.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,V948R None None XRAY 2.59 0.23 0.254 B 331.0 290.0 18 30 12 18 [[712, 970]] 1.0 8gb4 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8GB4C P00533 700 1012 1210.0 ANP:1102,YW5:1103 ATPlike,Type3 Inactive DFGin 4.7325 14.6021 BLBplus -141.16, 174.43 57.44, 44.8 -99.46, 158.79 49.11, 85.48 74.36, 22.53 out-out out 13.1853 Saltbr-out 11.5365 HRD-in -70.07, -59.0 77.64, -8.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.65 APE8-dihe-in -76.99, 66.94 APE8-rot-na 30.24 APE67-dihe-in -75.42, -5.6 -59.05, -41.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.014 T790M,V948R None None XRAY 2.59 0.23 0.254 C 331.0 297.0 16 30 14 16 [[712, 970]] 1.0 8gb4 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8GB4D P00533 700 1007 1210.0 ANP:1102,YW5:1103 ATPlike,Type3 Inactive DFGin 4.686 14.6978 BLBplus -141.21, 175.0 57.29, 43.49 -99.79, 159.92 51.61, 87.18 76.57, 22.15 out-out out 13.5607 Saltbr-out 10.9102 HRD-in -69.19, -58.43 79.07, -10.45 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 65.97 APE8-rot-na 30.21 APE67-dihe-in -74.96, -5.48 -59.31, -40.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,V948R None None XRAY 2.59 0.23 0.254 D 331.0 291.0 17 30 13 17 [[712, 970]] 1.0 8gb4 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7K1IA P00533 700 1007 1210.0 ANP:1102,VNS:1103 ATPlike,Type3 Inactive DFGin 4.8367 14.4122 BLBplus -124.92, 173.52 55.34, 38.4 -93.27, 168.4 51.69, 86.03 70.99, 11.24 out-out out 13.5963 Saltbr-out 12.2121 HRD-in -68.02, -55.76 76.66, -7.58 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.86 APE8-dihe-in -84.0, 73.03 APE8-rot-na 29.2 APE67-dihe-in -72.27, -9.54 -58.41, -42.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4195 L858R,V948R None None XRAY 3.202 0.266 0.311 A 331.0 288.0 20 30 13 17 [[712, 970]] 1.0 7k1i Homo sapiens TYR_EGFR_HUMAN TYR 8.5e-87 296.8 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1DC P00533 702 1006 1210.0 NQ1:1101,ANP:1102 Type3,ATPlike Inactive DFGin 5.3825 14.4593 BLBplus -142.0, 171.97 66.8, 29.01 -86.08, 152.7 44.82, 92.23 73.36, -11.9 out-out out 13.6137 Saltbr-out 13.7361 HRD-in -69.23, -60.69 76.65, -2.9 out-out-none SNCoon out-none ActLoopNT-out 6.7847 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 96.45 APE8-dihe-in -76.51, 79.09 APE8-rot-na 31.04 APE67-dihe-in -75.49, -1.74 -58.74, -40.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.2578 None None None XRAY 2.4 0.195 0.213 C 327.0 292.0 13 30 17 13 [[712, 970]] 1.0 6p1d Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1DD P00533 701 1008 1210.0 NQ1:1101,ANP:1102 Type3,ATPlike Inactive DFGin 4.7963 14.1019 BLBplus -132.01, 171.13 65.01, 17.93 -68.87, 143.86 51.94, 90.04 79.55, -15.22 out-out out 13.6224 Saltbr-out 13.7342 HRD-in -75.21, -58.43 80.83, -11.58 out-out-none SNCoon out-none ActLoopNT-out 6.6334 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.5 APE8-dihe-in -78.23, 70.43 APE8-rot-na 33.16 APE67-dihe-in -74.16, -5.23 -50.48, -45.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.2506 None None None XRAY 2.4 0.195 0.213 D 327.0 295.0 13 30 17 13 [[712, 970]] 1.0 6p1d Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXQA P00533 700 1007 1210.0 VNS:1102,ANP:1103 Type3,ATPlike Inactive DFGin 4.8599 14.5423 BLBplus -136.59, 171.99 58.78, 36.07 -93.08, 163.3 53.5, 85.99 81.0, 16.2 out-out out 13.5999 Saltbr-out 11.4015 HRD-in -66.89, -59.97 80.26, -12.87 out-out-out SNCooo out-out ActLoopNT-out 8.8337 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 0.37 APE9-dihe-in -62.95, 136.95 APE8-dihe-in -80.94, 64.03 APE8-rot-na 32.82 APE67-dihe-in -75.31, -4.79 -52.17, -43.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.4112 APE9-dist-out 8.2105 T790M,V948R None None XRAY 1.83 0.185 0.218 A 331.0 296.0 12 30 18 12 [[712, 970]] 1.0 7jxq Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXQC P00533 700 1007 1210.0 VNS:1102,ANP:1103 Type3,ATPlike Inactive DFGin 4.7845 14.4525 BLBplus -135.56, 173.47 59.34, 36.33 -94.04, 161.61 52.57, 85.94 80.36, 16.26 out-out out 13.5268 Saltbr-out 12.0328 HRD-in -65.88, -57.49 78.82, -12.32 out-out-none SNCoon out-none ActLoopNT-out 8.8194 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.15 APE8-dihe-in -80.46, 67.52 APE8-rot-na 31.26 APE67-dihe-in -73.66, -6.11 -51.25, -43.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.4339 T790M,V948R None None XRAY 1.83 0.185 0.218 C 331.0 298.0 10 30 20 10 [[712, 970]] 1.0 7jxq Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1DA P00533 700 1021 1210.0 ANP:1101 ATPlike Inactive DFGin 5.3014 16.4366 BLBtrans -129.26, 172.58 65.52, 23.29 -64.33, 142.93 151.16, 79.23 78.73, -15.31 out-out out 13.5195 Saltbr-out 12.421 HRD-in -76.98, -57.73 83.77, -12.82 out-out-none SNCoon out-none ActLoopNT-out 7.141 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 149.92 APE9-dihe-in -115.71, 137.77 APE8-dihe-in -79.58, 71.21 APE8-rot-na 32.94 APE67-dihe-in -73.74, -5.13 -51.22, -45.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.1838 APE9-dist-in 7.6772 None None None XRAY 2.4 0.195 0.213 A 327.0 309.0 13 30 17 13 [[712, 970]] 1.0 6p1d Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6WAKB P00533 701 1020 1210.0 ANP:1101 ATPlike Inactive DFGin 5.1768 16.2307 BLBtrans -117.23, 173.55 69.28, 15.65 -59.01, 135.6 148.98, 94.52 90.59, -20.79 out-out out 13.9491 Saltbr-out 13.5428 HRD-in -74.15, -58.44 85.37, -10.97 out-out-none SNCoon out-none ActLoopNT-out 6.4805 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -3.86 APE9-dihe-in -108.7, 124.16 APE8-dihe-in -81.26, 64.66 APE8-rot-na 31.83 APE67-dihe-in -71.85, -2.7 -48.1, -51.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.3657 APE9-dist-in 7.8264 T790M,V948R None None XRAY 2.4 0.219 0.23 B 328.0 316.0 4 30 26 4 [[712, 970]] 1.0 6wak Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6WXNB P00533 701 1021 1210.0 ANP:1101 ATPlike Inactive DFGin 5.2834 16.2947 BLBtrans -123.51, 174.07 66.96, 19.19 -61.23, 137.15 158.07, 75.44 91.96, -18.66 out-out out 13.5648 Saltbr-out 13.5233 HRD-in -75.09, -55.39 80.46, -8.33 out-out-none SNCoon out-none ActLoopNT-out 6.4801 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -21.86 APE9-dihe-in -115.99, 110.82 APE8-dihe-in -78.55, 77.75 APE8-rot-na 31.2 APE67-dihe-in -73.85, -5.28 -56.42, -42.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.8252 APE9-dist-in 7.8441 T790M,V948R None None XRAY 1.76 0.209 0.235 B 328.0 303.0 11 30 19 11 [[712, 970]] 1.0 6wxn Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8FV3B P00533 701 1021 1210.0 ANP:1102 ATPlike Inactive DFGin 5.4387 16.4957 BLBtrans -118.64, 177.37 63.4, 20.55 -58.75, 145.81 159.38, 77.34 77.7, -11.94 out-out out 13.9071 Saltbr-out 12.6093 HRD-in -79.27, -57.12 85.07, -16.18 out-out-none SNCoon out-none ActLoopNT-out 6.5505 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -85.47 APE9-dihe-in -94.5, 111.51 APE8-dihe-in -78.45, 79.51 APE8-rot-na 26.67 APE67-dihe-in -72.96, -7.53 -57.83, -45.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.1584 APE9-dist-in 7.6087 T790M,V948R None None XRAY 2.1 0.191 0.226 B 328.0 307.0 12 30 18 12 [[712, 970]] 1.0 8fv3 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8FV3D P00533 701 1008 1210.0 ANP:1102 ATPlike Inactive DFGin 5.123 16.0686 BLBtrans -118.91, 178.66 63.22, 20.1 -58.76, 136.59 151.59, 72.8 86.53, -14.56 out-out out 13.6355 Saltbr-out 11.8782 HRD-in -77.73, -54.76 83.51, -15.49 out-out-none SNCoon out-none ActLoopNT-out 6.6865 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -35.35 APE9-dihe-in -75.26, 139.37 APE8-dihe-in -77.41, 75.08 APE8-rot-na 30.35 APE67-dihe-in -77.52, -1.37 -56.44, -41.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.9892 APE9-dist-in 7.8559 T790M,V948R None None XRAY 2.1 0.191 0.226 D 328.0 295.0 13 30 18 12 [[712, 970]] 1.0 8fv3 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8FV4A P00533 701 1013 1210.0 ANP:1102 ATPlike Inactive DFGin 5.115 16.0834 BLBtrans -131.04, 178.71 63.39, 21.89 -65.77, 133.12 153.56, 67.25 81.77, -5.74 out-out out 13.9648 Saltbr-out 14.3656 HRD-in -75.29, -65.35 93.54, -10.41 out-out-out SNCooo out-out ActLoopNT-out 6.6138 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.22 APE8-dihe-in -79.99, 70.44 APE8-rot-na 34.65 APE67-dihe-in -69.8, 5.09 -60.12, -39.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.0271 T790M,V948R None None XRAY 2.2 0.204 0.261 A 328.0 298.0 15 30 17 13 [[712, 970]] 1.0 8fv4 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO3C P00533 702 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 5.7531 16.5332 BLBtrans -133.38, -174.65 59.98, 24.74 -65.74, 136.64 157.32, 80.88 79.44, -13.7 out-out out 13.6547 Saltbr-out 13.5313 HRD-in -66.43, -56.05 80.37, -11.56 out-out-out SNCooo out-out ActLoopNT-out 6.3729 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.97 APE8-dihe-in -84.11, 59.51 APE8-rot-na 29.31 APE67-dihe-in -74.18, -0.3 -51.78, -42.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.1735 T790M,V948R None None XRAY 2.49 0.231 0.269 C 328.0 295.0 16 30 17 13 [[712, 970]] 1.0 8to3 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO3D P00533 702 1008 1210.0 ANP:1102 ATPlike Inactive DFGin 6.2656 16.7122 BLBtrans -127.69, 172.31 68.6, 30.15 -69.25, 140.14 165.75, 69.84 67.25, -4.22 out-out out 14.3859 Saltbr-out 13.1993 HRD-in -68.61, -53.44 82.24, -15.94 out-out-out SNCooo out-out ActLoopNT-out 6.5519 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 120.24 APE8-dihe-in -79.84, 75.73 APE8-rot-na 31.27 APE67-dihe-in -78.58, -0.75 -60.94, -39.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.144 T790M,V948R None None XRAY 2.49 0.231 0.269 D 328.0 293.0 14 30 17 13 [[712, 970]] 1.0 8to3 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO4A P00533 701 1021 1210.0 ANP:1102 ATPlike Inactive DFGin 5.6288 16.5475 BLBtrans -124.14, -173.94 46.92, 31.67 -57.81, 155.21 158.64, 67.25 48.87, 11.58 out-out out 13.9601 Saltbr-out 13.5608 HRD-in -72.61, -58.43 93.96, -37.09 out-out-none SNCoon out-none ActLoopNT-out 6.9316 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 82.65 APE8-dihe-in -66.65, 104.87 APE8-rot-na 26.84 APE67-dihe-in -69.56, -10.93 -75.01, -49.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.7236 T790M,V948R None None XRAY 2.99 0.176 0.231 A 328.0 300.0 16 30 17 13 [[712, 970]] 1.0 8to4 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4ZSEA P00533 699 1007 1210.0 ANP:1101 ATPlike Inactive DFGin 5.3349 16.1805 BLBtrans -132.89, 171.35 59.18, 30.95 -64.3, 136.47 153.66, 69.99 84.54, -7.18 out-out out 13.4098 Saltbr-out 12.5416 HRD-in -69.44, -53.13 80.36, -12.32 out-out-none SNCoon out-none ActLoopNT-out 6.4997 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 151.84 APE9-dihe-in -73.75, 154.61 APE8-dihe-in -84.04, 78.01 APE8-rot-na 31.44 APE67-dihe-in -73.82, -9.83 -53.67, -42.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.7536 APE9-dist-in 7.6313 T790M,V948R None None XRAY 1.97 0.191 0.213 A 331.0 297.0 12 30 18 12 [[712, 970]] 1.0 4zse Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4ZSEB P00533 698 1022 1210.0 ANP:2001 ATPlike Inactive DFGin 5.4426 16.5343 BLBtrans -132.18, 168.84 69.74, 21.23 -63.33, 134.02 158.02, 77.95 88.87, -12.59 out-out out 13.5937 Saltbr-out 12.7288 HRD-in -70.54, -56.98 84.69, -9.62 out-out-none SNCoon out-none ActLoopNT-out 6.279 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -169.23 APE9-dihe-in -113.21, 138.46 APE8-dihe-in -83.6, 77.16 APE8-rot-na 29.29 APE67-dihe-in -64.08, -26.4 -59.09, -39.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.0951 APE9-dist-in 7.6641 T790M,V948R None None XRAY 1.97 0.191 0.213 B 331.0 313.0 12 30 18 12 [[712, 970]] 1.0 4zse Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4ZSEC P00533 700 1013 1210.0 ANP:3001 ATPlike Inactive DFGin 5.5274 16.5509 BLBtrans -132.06, 169.7 72.1, 15.79 -57.63, 131.91 161.52, 79.23 90.56, -14.81 out-out out 13.4639 Saltbr-out 12.8398 HRD-in -70.03, -52.52 81.38, -14.98 out-out-none SNCoon out-none ActLoopNT-out 6.2175 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.83 APE8-dihe-in -83.98, 70.07 APE8-rot-na 31.43 APE67-dihe-in -69.54, -11.42 -60.89, -38.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.9162 T790M,V948R None None XRAY 1.97 0.191 0.213 C 331.0 301.0 13 30 17 13 [[712, 970]] 1.0 4zse Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXMA P00533 700 1007 1210.0 ANP:1101 ATPlike Inactive DFGin 4.9584 16.1723 BLBtrans -132.35, 172.29 62.1, 35.15 -75.21, 146.26 142.71, 77.54 74.06, -11.26 out-out out 13.8943 Saltbr-out 13.3399 HRD-in -71.64, -59.02 81.62, -5.92 out-out-none SNCoon out-none ActLoopNT-out 8.0723 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 131.88 APE8-dihe-in -79.6, 70.11 APE8-rot-na 34.33 APE67-dihe-in -76.06, -4.61 -47.57, -45.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.5303 T790M,V948R None None XRAY 2.192 0.228 0.271 A 331.0 287.0 18 30 16 14 [[712, 970]] 1.0 7jxm Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2GS7A P00533 703 1012 1210.0 ANP:60301 ATPlike Inactive DFGin 5.3734 16.6335 BLBtrans -99.51, 171.1 60.81, 33.31 -69.51, 142.46 163.35, 73.66 92.75, -41.51 out-out out 14.0894 Saltbr-out 13.0754 HRD-in -69.91, -45.27 73.69, -18.97 out-out-out SNCooo out-out ActLoopNT-out 6.362 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 134.47 APE9-dihe-in -142.48, 136.32 APE8-dihe-in -67.69, 63.71 APE8-rot-na 37.05 APE67-dihe-in -69.28, 11.68 -49.57, -49.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.0118 APE9-dist-out 8.2 V948R None None XRAY 2.6 0.258 0.298 A 330.0 281.0 4 30 26 4 [[712, 970]] 1.0 2gs7 Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2GS7B P00533 701 1016 1210.0 ANP:60302 ATPlike Inactive DFGin 5.284 16.3489 BLBtrans -104.25, 165.26 71.85, 26.96 -61.96, 139.7 163.92, 72.26 85.01, -32.88 out-out out 13.995 Saltbr-out 14.3086 HRD-in -67.25, -42.1 68.95, -3.07 out-out-none SNCoon out-none ActLoopNT-out 6.4734 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 151.84 APE9-dihe-in -148.05, 134.8 APE8-dihe-in -62.95, 72.83 APE8-rot-na 33.79 APE67-dihe-in -67.93, 1.22 -55.72, -45.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.1301 APE9-dist-in 7.9025 V948R None None XRAY 2.6 0.258 0.298 B 330.0 288.0 3 30 27 3 [[712, 970]] 1.0 2gs7 Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3GT8A P00533 700 1014 1210.0 ANP:60002 ATPlike Inactive DFGin 4.9934 16.3899 BLBtrans -126.87, 160.91 79.29, 15.25 -62.33, 143.15 149.45, 88.24 77.42, 3.92 out-out out 14.0883 Saltbr-out 14.9565 HRD-in -72.04, -61.33 88.51, -0.69 out-out-none SNCoon out-none ActLoopNT-out 6.5602 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 19.46 APE8-rot-na 342.23 APE67-dihe-in -68.79, -19.52 -40.63, -50.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V948R None None XRAY 2.955 0.219 0.275 A 330.0 300.0 15 30 15 15 [[712, 970]] 1.0 3gt8 Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3GT8B P00533 701 1007 1210.0 ANP:60001 ATPlike Inactive DFGin 5.2466 16.1025 BLBtrans -113.7, -174.86 52.25, 31.77 -67.43, 143.58 157.41, 75.54 60.22, 2.12 out-out out 13.3548 Saltbr-out 13.7165 HRD-in -65.21, -59.58 85.13, -27.25 out-out-none SNCoon out-none ActLoopNT-out 6.3836 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 3.18 APE8-rot-na 352.22 APE67-dihe-in -64.44, -9.93 -42.76, -50.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V948R None None XRAY 2.955 0.219 0.275 B 330.0 292.0 15 30 15 15 [[712, 970]] 1.0 3gt8 Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3GT8C P00533 699 1007 1210.0 ANP:60003 ATPlike Inactive DFGin 4.7311 16.0424 BLBtrans -111.03, -172.93 50.46, 27.13 -68.53, 136.25 146.08, 72.89 59.13, 17.74 out-out out 14.315 Saltbr-out 13.2834 HRD-in -57.94, -53.03 83.1, -30.64 out-out-none SNCoon out-none ActLoopNT-out 6.5164 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 131.04 APE8-dihe-in -73.71, 55.48 APE8-rot-na 345.44 APE67-dihe-in -72.77, 4.68 -41.49, -48.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.982 V948R None None XRAY 2.955 0.219 0.275 C 330.0 296.0 13 30 17 13 [[712, 970]] 1.0 3gt8 Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3GT8D P00533 701 1010 1210.0 ANP:60004 ATPlike Inactive DFGin 5.2361 16.3468 BLBtrans -129.98, 167.43 62.52, 32.14 -70.14, 140.82 152.86, 71.47 77.5, -20.57 out-out out 14.0591 Saltbr-out 13.5142 HRD-in -61.66, -53.51 87.8, -16.84 out-out-none SNCoon out-none ActLoopNT-out 6.7968 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 30.46 APE8-rot-na 344.36 APE67-dihe-in -63.75, 2.23 -59.31, -42.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V948R None None XRAY 2.955 0.219 0.275 D 330.0 295.0 15 30 15 15 [[712, 970]] 1.0 3gt8 Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CNOA P00533 700 1015 1210.0 ANP:61001 ATPlike Inactive DFGin 5.5039 16.1608 BLBtrans -118.04, 171.2 68.22, 21.52 -56.79, 132.54 171.14, 68.18 99.53, -19.86 out-out out 13.7182 Saltbr-out 12.9439 HRD-in -82.44, -48.26 77.49, -9.43 out-out-out SNCooo out-out ActLoopNT-out 6.3415 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 122.24 APE9-dihe-in -77.97, 140.5 APE8-dihe-in -80.47, 64.47 APE8-rot-na 27.48 APE67-dihe-in -78.06, -5.87 -50.51, -36.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.5884 APE9-dist-out 8.271 V948R None None XRAY 1.55 0.176 0.203 A 330.0 300.0 16 30 19 11 [[712, 970]] 1.0 5cno Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CNNB P00533 700 1014 1210.0 ANP:61101 ATPlike Inactive DFGin 5.5714 16.3897 BLBtrans -117.7, 174.34 67.16, 24.17 -60.91, 135.45 168.23, 72.49 97.23, -21.68 out-out out 13.7881 Saltbr-out 12.7591 HRD-in -80.25, -51.08 77.81, -11.48 out-out-out SNCooo out-out ActLoopNT-out 6.3744 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -75.45 APE9-dihe-in -63.67, 125.67 APE8-dihe-in -78.86, 65.92 APE8-rot-na 30.44 APE67-dihe-in -73.57, -5.24 -51.98, -40.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.0859 APE9-dist-out 8.2793 I706Q None None XRAY 1.9 0.183 0.211 B 350.0 304.0 11 30 19 11 [[712, 970]] 1.0 5cnn Homo sapiens TYR_EGFR_HUMAN TYR 1.3e-87 299.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5X2AB P00533 700 1022 1210.0 7XO:1105,ANP:1106 Type1,ATPlike Inactive DFGin 5.521 16.3794 BLBtrans -118.08, 178.13 68.28, 22.21 -63.57, 132.1 161.37, 67.84 99.95, -15.3 out-out out 13.8924 Saltbr-out 13.5052 HRD-in -67.87, -49.57 81.65, -13.01 out-out-out SNCooo out-out ActLoopNT-out 6.3644 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -63.35, -22.61 APE9-dihe-in -95.03, 108.56 APE8-dihe-in -83.98, 72.85 APE8-rot-na 21.28 APE67-dihe-in -71.39, -9.89 -59.75, -39.3 APE12-dist-na 15.7264 APE11-dist-na 13.2452 APE10-dist-na 9.2736 APE9-dist-in 7.5679 T790M,V948R None None XRAY 1.85 0.176 0.219 B 331.0 322.0 0 30 30 0 [[712, 970]] 1.0 5x2a Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5X2AA P00533 700 1011 1210.0 7XO:1107,ANP:1108 Type1,Allosteric Inactive DFGin 5.5648 16.303 BLBtrans -120.52, 179.71 70.51, 14.21 -61.87, 136.6 165.52, 70.66 90.66, -18.93 out-out out 13.7777 Saltbr-out 13.1042 HRD-in -79.48, -46.8 73.07, -8.08 out-out-none SNCoon out-none ActLoopNT-out 6.728 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 152.51 APE8-dihe-in -84.48, 76.35 APE8-rot-na 26.1 APE67-dihe-in -71.21, -12.48 -60.14, -38.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.7618 T790M,V948R None None XRAY 1.85 0.176 0.219 A 331.0 297.0 13 30 17 13 [[712, 970]] 1.0 5x2a Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EPHA2 EPHA2_HUMAN 1MQBA P29317 605 887 976.0 ANP:1000 ATPlike Inactive DFGin 5.7122 14.9239 BLAminus -127.53, -172.03 57.53, 74.63 -109.94, 122.74 306.64, 100.38 176.53, 104.78 in-out in 8.4647 Saltbr-out 5.6749 HRD-in -62.1, -45.48 77.42, -17.66 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -37.06 APE9-dihe-in -88.14, 119.95 APE8-dihe-in -73.81, 144.85 APE8-rot-na 33.04 APE67-dihe-in -82.72, 0.0 -54.3, -43.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.5534 APE9-dist-in 5.5976 None None None XRAY 2.3 0.237 0.288 A 333.0 263.0 20 31 14 17 [[613, 873]] 1.0 1mqb Homo sapiens TYR_EPHA2_HUMAN TYR 7.4e-108 365.7 2.0 261.0 260.0 756 757 758 760 762 646 663 667 736 738 737 739.0 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 1MQBB P29317 602 883 976.0 ANP:1001 ATPlike None DFGin 5.6905 14.8889 BLAminus -139.65, -173.77 51.28, 81.33 -92.67, 10.65 292.99, 95.58 -41.77, -44.65 in-in in 8.2733 Saltbr-in 2.6399 HRD-in -72.65, -50.06 79.19, -16.04 in-in-none SNCiin in-none ActLoopNT-in 2.9923 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -50.3 APE9-dihe-in -134.32, 148.66 APE8-dihe-in -83.15, 83.63 APE8-rot-na 31.61 APE67-dihe-in -80.07, -2.61 -53.54, -47.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.3278 APE9-dist-in 6.6333 None None None XRAY 2.3 0.237 0.288 B 333.0 265.0 17 31 18 13 [[613, 873]] 1.0 1mqb Homo sapiens TYR_EPHA2_HUMAN TYR 7.4e-108 365.7 2.0 261.0 260.0 756 757 758 760 762 646 663 667 736 738 737 739.0 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 5I9WA P29317 605 895 976.0 ANP:1001 ATPlike Inactive DFGin 6.2443 15.2815 BLBminus -125.95, -162.36 67.3, 57.63 -98.89, 156.85 294.37, 103.89 164.47, 175.48 in-in in 8.3467 Saltbr-in 2.7642 HRD-in -75.49, -48.49 78.15, -15.84 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.31 APE8-dihe-in -84.75, 145.17 APE8-rot-na 35.12 APE67-dihe-in -78.8, -3.01 -55.81, -43.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.3423 None None None XRAY 1.359 0.17 0.18 A 306.0 267.0 24 31 13 18 [[613, 873]] 1.0 5i9w Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2.0 261.0 260.0 756 757 758 760 762 646 663 667 736 738 737 739.0 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA3 EPHA3_HUMAN 2QOCA P29320 613 906 983.0 ANP:949 ATPlike Inactive DFGin 4.9949 15.4446 BLAminus -141.69, -171.73 58.63, 84.29 -97.26, 21.84 297.12, 103.61 -61.69, -31.71 in-out in 9.4946 Saltbr-out 6.0476 HRD-in -71.05, -48.03 74.01, -8.74 out-in-none SNCoin in-none ActLoopNT-in 3.023 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 135.66 APE9-dihe-in -81.0, 137.87 APE8-dihe-in -77.44, 99.9 APE8-rot-na 34.81 APE67-dihe-in -63.09, -22.76 -54.0, -44.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.2139 APE9-dist-in 5.5143 None None None XRAY 1.25 0.17 0.186 A 344.0 283.0 11 31 20 11 [[621, 880]] 1.0 2qoc Homo sapiens TYR_EPHA3_HUMAN TYR 8.4e-111 375.4 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 3FXXA P29320 606 904 983.0 ANP:992 ATPlike Inactive DFGin 4.9 15.171 BLAminus -132.57, -176.13 56.24, 78.37 -91.43, 22.66 298.54, 96.01 -59.15, -30.35 in-out in 9.3764 Saltbr-out 4.2542 HRD-in -72.67, -46.91 76.32, -4.64 out-in-in SNCoii in-in ActLoopNT-in 2.804 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.39, 147.18 APE9-dihe-in -116.01, 151.61 APE8-dihe-in -77.44, 77.25 APE8-rot-na 30.85 APE67-dihe-in -60.25, -20.23 -50.19, -49.06 APE12-dist-na 999.0 APE11-dist-na 8.9995 APE10-dist-na 10.1833 APE9-dist-in 6.2382 A608T None None XRAY 1.7 0.168 0.194 A 371.0 288.0 9 31 22 9 [[621, 880]] 1.0 3fxx Homo sapiens TYR_EPHA3_HUMAN TYR 1.1e-110 375.1 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2QO7A P29320 595 904 983.0 ANP:1000 ATPlike Inactive DFGin 5.4809 15.5563 BLAminus -130.76, -168.32 68.6, 58.57 -92.37, 46.9 297.61, 96.94 -87.84, 999.0 in-out in 8.4003 Saltbr-out 4.3475 HRD-in -73.41, -45.48 73.79, -12.75 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 85.99 APE8-rot-na 29.77 APE67-dihe-in -61.7, -25.84 -53.26, -41.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None PTR701 PTR701 XRAY 1.605 0.186 0.224 A 373.0 279.0 20 31 11 20 [[621, 880]] 1.0 2qo7 Homo sapiens TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2QO9A P29320 608 904 983.0 ANP:948 ATPlike Inactive DFGin 5.2052 15.375 BLAminus -133.34, -177.89 59.05, 80.14 -92.65, 15.74 295.85, 100.25 -55.83, -40.55 in-out in 9.2347 Saltbr-out 4.2304 HRD-in -71.62, -45.86 73.18, -10.67 out-in-out SNCoio in-out ActLoopNT-in 2.9965 ActLoopCT-out TYR APEdihe_noiai APEdist_aaai APE10-dihe-none 999.0, 105.46 APE9-dihe-out 41.85, 78.2 APE8-dihe-in -71.02, 94.17 APE8-rot-na 29.94 APE67-dihe-in -61.69, -23.23 -54.76, -43.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.1675 APE9-dist-in 5.8543 None None None XRAY 1.55 0.183 0.211 A 373.0 277.0 13 31 18 13 [[621, 880]] 1.0 2qo9 Homo sapiens TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2QOQA P29320 595 906 983.0 ANP:948 ATPlike None DFGin 5.3598 15.5746 BLAminus -132.4, -170.9 64.35, 72.55 -105.5, 56.47 301.01, 91.74 -101.2, 999.0 in-in in 8.6353 Saltbr-in 2.7272 HRD-in -73.3, -48.21 73.66, -6.72 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 133.24 APE9-dihe-in -154.49, 111.52 APE8-dihe-in -76.14, 92.58 APE8-rot-na 29.51 APE67-dihe-in -62.32, -22.8 -60.77, -45.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.7427 None PTR701 PTR701 XRAY 1.6 0.19 0.219 A 373.0 285.0 18 31 13 18 [[621, 880]] 1.0 2qoq Homo sapiens TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR ERBB3 ERBB3_HUMAN 3KEXA P21860 698 994 1342.0 ANP:60001 ATPlike Pseudo DFGin 5.6601 12.692 BLBplus -136.97, 172.9 58.22, 40.12 -96.04, 155.03 48.2, 92.31 69.55, -19.76 out-na out 15.2354 Saltbr-na 999.0 HRD-in -90.16, -54.52 74.78, -7.72 na-out-out SNCaoo out-out ActLoopNT-out 6.7279 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.57 APE8-dihe-out -99.2, 24.49 APE8-rot-na 333.43 APE67-dihe-in -74.24, 11.38 -68.56, -18.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.7737 None None None XRAY 2.797 0.243 0.283 A 325.0 292.0 5 30 25 5 [[709, 967]] 1.0 3kex Homo sapiens TYR_ERBB3_HUMAN TYR 6e-80 274.2 2.0 260.0 259.0 851 852 853 855 857 742 759 763 831 833 832 834.0 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 3KEXB P21860 698 988 1342.0 ANP:60002 ATPlike Pseudo DFGin 5.652 12.6727 BLBplus -137.46, 172.26 58.51, 39.18 -94.14, 155.27 47.87, 93.32 68.94, -19.33 out-na out 15.2321 Saltbr-na 999.0 HRD-in -90.89, -54.23 74.6, -7.22 na-out-out SNCaoo out-out ActLoopNT-out 6.7271 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 145.38 APE8-dihe-out -51.8, -10.63 APE8-rot-na 330.98 APE67-dihe-in -73.43, 11.3 -67.12, -27.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.2152 None None None XRAY 2.797 0.243 0.283 B 325.0 283.0 7 30 23 7 [[709, 967]] 1.0 3kex Homo sapiens TYR_ERBB3_HUMAN TYR 6e-80 274.2 2.0 260.0 259.0 851 852 853 855 857 742 759 763 831 833 832 834.0 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIWA P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.6652 12.9195 BLBplus -124.68, 170.7 61.91, 32.93 -86.72, 138.2 53.99, 90.7 80.0, -6.46 out-na out 15.1205 Saltbr-na 999.0 HRD-in -76.0, -53.69 67.87, 2.11 na-out-none SNCaon out-none ActLoopNT-out 6.6323 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -2.58 APE8-rot-na 28.66 APE67-dihe-in -88.2, -5.19 -70.28, -23.24 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 3.1 0.233 0.287 A 326.0 269.0 12 30 18 12 [[709, 967]] 1.0 4riw Homo sapiens TYR_ERBB3_HUMAN TYR 6.1e-80 274.2 2.0 260.0 259.0 851 852 853 855 857 742 759 763 831 833 832 834.0 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIWC P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.6184 13.0319 BLBplus -125.06, 170.64 62.1, 33.09 -86.97, 138.33 54.47, 90.5 80.01, -6.38 out-na out 15.4904 Saltbr-na 999.0 HRD-in -75.9, -53.21 67.39, 0.69 na-out-out SNCaoo out-out ActLoopNT-out 6.3934 ActLoopCT-out TYR APEdihe_oioai APEdist_aaao APE10-dihe-out -113.39, 20.05 APE9-dihe-in -68.39, 127.6 APE8-dihe-out -63.99, -4.42 APE8-rot-na 333.17 APE67-dihe-in -86.76, -6.22 -71.15, -22.24 APE12-dist-na 21.5437 APE11-dist-na 20.4194 APE10-dist-na 15.4077 APE9-dist-out 10.083 None None None XRAY 3.1 0.233 0.287 C 326.0 275.0 6 30 30 0 [[709, 967]] 1.0 4riw Homo sapiens TYR_ERBB3_HUMAN TYR 6.1e-80 274.2 2.0 260.0 259.0 851 852 853 855 857 742 759 763 831 833 832 834.0 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 3LMGA P21860 699 978 1342.0 ANP:60301 ATPlike Pseudo DFGin 5.7284 12.9636 BLBplus -117.83, 170.87 63.58, 24.7 -69.26, 132.03 43.93, 98.75 70.87, 7.13 out-na out 15.5784 Saltbr-na 999.0 HRD-in -64.67, -52.37 74.61, 1.05 na-out-out SNCaoo out-out ActLoopNT-out 6.623 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 104.53 APE8-dihe-out -45.34, -17.97 APE8-rot-na 330.0 APE67-dihe-in -71.66, -7.63 -57.32, -31.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.4636 None None None XRAY 2.8 0.255 0.285 A 344.0 268.0 12 30 21 9 [[709, 967]] 1.0 3lmg Homo sapiens TYR_ERBB3_HUMAN TYR 7.3e-80 274.0 2.0 260.0 259.0 851 852 853 855 857 742 759 763 831 833 832 834.0 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 3LMGB P21860 699 978 1342.0 ANP:60301 ATPlike Pseudo DFGin 5.789 12.8435 BLBplus -113.43, 165.54 66.13, 22.95 -73.3, 147.22 48.63, 94.29 81.01, -18.45 out-na out 15.3813 Saltbr-na 999.0 HRD-in -77.74, -52.9 74.69, -13.1 na-out-none SNCaon out-none ActLoopNT-out 6.8052 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -22.84 APE8-rot-na 330.0 APE67-dihe-in -67.55, -12.53 -55.83, -37.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.255 0.285 B 344.0 268.0 12 30 21 9 [[709, 967]] 1.0 3lmg Homo sapiens TYR_ERBB3_HUMAN TYR 7.3e-80 274.0 2.0 260.0 259.0 851 852 853 855 857 742 759 763 831 833 832 834.0 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIYA P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.753 12.8685 BLBplus -123.9, 168.71 62.98, 31.45 -82.39, 142.59 52.35, 86.17 78.8, -6.78 out-na out 15.0438 Saltbr-na 999.0 HRD-in -75.26, -54.75 69.16, 2.85 na-out-none SNCaon out-none ActLoopNT-out 6.4496 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -9.22 APE8-rot-na 31.12 APE67-dihe-in -85.56, -1.17 -67.69, -25.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 E928G None None XRAY 2.981 0.221 0.267 A 326.0 269.0 12 30 18 12 [[709, 967]] 1.0 4riy Homo sapiens TYR_ERBB3_HUMAN TYR 1.3e-79 273.1 2.0 260.0 259.0 851 852 853 855 857 742 759 763 831 833 832 834.0 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIYC P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.5774 13.185 BLBplus -124.39, 168.66 63.11, 31.61 -82.48, 141.95 52.91, 86.81 78.36, -7.08 out-na out 15.6054 Saltbr-na 999.0 HRD-in -74.67, -54.96 68.56, 2.02 na-out-out SNCaoo out-out ActLoopNT-out 6.5253 ActLoopCT-out TYR APEdihe_oioai APEdist_aaao APE10-dihe-out -99.97, 8.97 APE9-dihe-in -62.65, 132.93 APE8-dihe-out -66.25, -9.79 APE8-rot-na 341.07 APE67-dihe-in -85.25, -1.58 -67.21, -25.34 APE12-dist-na 22.2853 APE11-dist-na 20.5354 APE10-dist-na 15.6134 APE9-dist-out 10.1634 E928G None None XRAY 2.981 0.221 0.267 C 326.0 275.0 6 30 30 0 [[709, 967]] 1.0 4riy Homo sapiens TYR_ERBB3_HUMAN TYR 1.3e-79 273.1 2.0 260.0 259.0 851 852 853 855 857 742 759 763 831 833 832 834.0 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIXA P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.5341 12.788 BLBplus -125.2, 170.11 60.89, 28.84 -82.14, 140.77 56.51, 90.87 77.72, -6.25 out-na out 15.0398 Saltbr-na 999.0 HRD-in -77.1, -53.12 66.52, 0.72 na-out-none SNCaon out-none ActLoopNT-out 6.5125 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -5.5 APE8-rot-na 30.9 APE67-dihe-in -82.84, -10.3 -67.07, -25.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q809R None None XRAY 3.1 0.21 0.258 A 326.0 269.0 12 30 18 12 [[709, 967]] 1.0 4rix Homo sapiens TYR_ERBB3_HUMAN TYR 9.7e-80 273.5 2.0 260.0 259.0 851 852 853 855 857 742 759 763 831 833 832 834.0 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIXC P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.5566 13.1159 BLBplus -126.64, 170.72 61.2, 28.92 -82.69, 140.73 56.76, 91.32 77.44, -6.2 out-na out 15.4732 Saltbr-na 999.0 HRD-in -76.48, -52.61 66.58, -0.13 na-out-out SNCaoo out-out ActLoopNT-out 6.3725 ActLoopCT-out TYR APEdihe_oioai APEdist_aaao APE10-dihe-out -112.15, 5.58 APE9-dihe-in -58.87, 135.06 APE8-dihe-out -71.85, -6.39 APE8-rot-na 348.17 APE67-dihe-in -82.4, -10.58 -67.81, -25.66 APE12-dist-na 21.6583 APE11-dist-na 20.6117 APE10-dist-na 15.6054 APE9-dist-out 9.9687 Q809R None None XRAY 3.1 0.21 0.258 C 326.0 275.0 6 30 30 0 [[709, 967]] 1.0 4rix Homo sapiens TYR_ERBB3_HUMAN TYR 9.7e-80 273.5 2.0 260.0 259.0 851 852 853 855 857 742 759 763 831 833 832 834.0 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR FGFR2 FGFR2_HUMAN 5UGLA P21802 468 764 821.0 ANP:802 ATPlike Inactive DFGin 6.7324 14.4645 BLAminus -137.83, -175.53 60.75, 66.42 -85.03, 17.04 287.79, 92.86 -66.15, -23.38 in-in in 7.6692 Saltbr-in 2.7606 HRD-in -76.2, -48.26 75.23, -6.81 in-in-out SNCiio in-out ActLoopNT-in 2.8649 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.99, 26.82 APE9-dihe-in -107.7, 135.68 APE8-dihe-in -52.5, 118.32 APE8-rot-na 330.79 APE67-dihe-in -70.92, -8.04 -59.23, -38.34 APE12-dist-na 14.8866 APE11-dist-na 10.816 APE10-dist-na 7.6416 APE9-dist-in 5.1026 D650V None None XRAY 1.861 0.221 0.258 A 324.0 285.0 12 30 30 0 [[481, 759]] 1.0 5ugl Homo sapiens TYR_FGFR2_HUMAN TYR 4.3e-104 353.4 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5UGLB P21802 467 764 821.0 ANP:802 ATPlike Inactive DFGin 6.7377 14.4797 BLAminus -137.57, -172.18 55.78, 69.64 -87.75, 15.81 286.63, 92.96 -64.54, -22.36 in-in in 7.6528 Saltbr-in 2.7177 HRD-in -74.83, -48.38 75.49, -7.57 in-in-out SNCiio in-out ActLoopNT-in 2.8681 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.07, 25.73 APE9-dihe-in -107.84, 135.51 APE8-dihe-in -51.06, 118.2 APE8-rot-na 329.13 APE67-dihe-in -71.28, -8.69 -57.7, -39.45 APE12-dist-na 999.0 APE11-dist-na 10.8311 APE10-dist-na 7.6693 APE9-dist-in 5.0837 D650V None None XRAY 1.861 0.221 0.258 B 324.0 271.0 27 30 19 11 [[481, 759]] 1.0 5ugl Homo sapiens TYR_FGFR2_HUMAN TYR 4.3e-104 353.4 1.0 260.0 260.0 643 644 645 647 649 517 534 538 623 625 624 626.0 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR HCK HCK_HUMAN 1AD5A P08631 79 526 526.0 ANP:60001 ATPlike Inactive DFGin 6.8776 13.5562 BLAminus -111.54, 157.75 55.86, 95.53 -99.86, -56.89 321.06, 144.41 -91.88, 132.97 out-out out 13.5916 Saltbr-out 14.4523 HRD-out -92.59, 96.14 -56.64, -30.38 out-out-out SNCooo out-out ActLoopNT-out 11.4135 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -107.24, 53.46 APE9-dihe-in -96.28, 143.43 APE8-dihe-out -62.47, 38.68 APE8-rot-na 35.25 APE67-dihe-in -59.4, -26.12 -40.35, -46.47 APE12-dist-na 11.6595 APE11-dist-na 16.6044 APE10-dist-na 16.1334 APE9-dist-out 10.4142 None PTR522 PTR522 XRAY 2.6 0.239 0.307 A 438.0 438.0 0 29 29 0 [[262, 513]] 1.0 1ad5 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-88 303.1 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 1AD5B P08631 79 526 526.0 ANP:60532 ATPlike Inactive DFGin 6.635 13.5293 BLAminus -108.53, 152.83 57.68, 95.37 -100.87, -57.78 321.85, 133.69 -88.86, 132.45 out-out out 13.5911 Saltbr-out 14.3339 HRD-out -97.62, 96.0 -55.31, -32.54 out-out-out SNCooo out-out ActLoopNT-out 11.4801 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.78, 54.95 APE9-dihe-in -97.18, 143.16 APE8-dihe-out -68.08, 36.88 APE8-rot-na 32.16 APE67-dihe-in -59.62, -27.02 -36.62, -45.49 APE12-dist-na 11.6841 APE11-dist-na 16.5851 APE10-dist-na 16.2062 APE9-dist-out 10.5337 None PTR522 PTR522 XRAY 2.6 0.239 0.307 B 438.0 438.0 0 29 29 0 [[262, 513]] 1.0 1ad5 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-88 303.1 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR IGF1R IGF1R_HUMAN 1JQHA P08069 984 1286 1367.0 ANP:301 ATPlike Inactive DFGin 5.6898 16.5691 None -66.7, 163.88 -59.45, 151.32 -140.18, 178.07 43.94, 89.38 -106.76, 173.06 in-out in 9.9768 Saltbr-out 6.0561 HRD-in -50.88, -56.96 74.77, -3.78 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -84.24, 106.81 APE9-dihe-in -58.88, 134.76 APE8-dihe-in -78.96, 121.64 APE8-rot-na 37.96 APE67-dihe-in -60.45, -7.73 -52.46, -43.95 APE12-dist-na 7.1567 APE11-dist-na 11.2997 APE10-dist-na 15.5969 APE9-dist-in 5.8 E979G,Y980S None None XRAY 2.1 0.195 0.219 A 308.0 291.0 12 30 23 7 [[999, 1268]] 1.0 1jqh Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 1JQHB P08069 984 1286 1367.0 ANP:302 ATPlike Inactive DFGin 5.6866 16.5538 None -65.78, 164.4 -59.98, 151.89 -140.81, 178.2 43.68, 89.42 -109.69, -174.77 in-out in 9.9884 Saltbr-out 6.0195 HRD-in -51.69, -56.66 74.32, -2.97 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.6, 107.67 APE9-dihe-in -58.75, 135.36 APE8-dihe-in -79.54, 122.52 APE8-rot-na 37.69 APE67-dihe-in -59.25, -7.46 -52.18, -45.28 APE12-dist-na 6.8166 APE11-dist-na 10.9316 APE10-dist-na 15.2162 APE9-dist-in 5.768 E979G,Y980S None None XRAY 2.1 0.195 0.219 B 308.0 287.0 16 30 23 7 [[999, 1268]] 1.0 1jqh Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 1JQHC P08069 984 1286 1367.0 ANP:303 ATPlike Inactive DFGin 5.6976 16.5582 None -65.47, 162.73 -58.75, 151.62 -140.8, 179.03 43.87, 88.98 -110.24, -177.72 in-out in 9.9987 Saltbr-out 6.0347 HRD-in -53.2, -57.0 74.59, -2.63 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.9, 107.89 APE9-dihe-in -58.88, 134.76 APE8-dihe-in -79.04, 122.75 APE8-rot-na 38.27 APE67-dihe-in -60.34, -8.42 -53.61, -43.61 APE12-dist-na 6.9265 APE11-dist-na 10.9862 APE10-dist-na 15.2452 APE9-dist-in 5.7735 E979G,Y980S None None XRAY 2.1 0.195 0.219 C 308.0 291.0 12 30 23 7 [[999, 1268]] 1.0 1jqh Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1.0 260.0 260.0 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135.0 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR INSR INSR_HUMAN 1IR3A P06213 1008 1310 1382.0 ANP:60300 ATPlike Inactive DFGin 6.1283 14.366 BLAminus -133.72, -168.17 47.48, 85.02 -100.33, 24.62 303.32, 104.39 -58.78, -39.74 in-out in 8.9234 Saltbr-out 4.3926 HRD-in -68.06, -49.87 71.52, -7.17 out-in-in SNCoii in-in ActLoopNT-in 2.9018 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.98, 116.19 APE9-dihe-in -117.81, 138.98 APE8-dihe-in -77.82, 71.42 APE8-rot-na 34.55 APE67-dihe-in -66.85, -13.55 -40.74, -47.32 APE12-dist-na 14.5115 APE11-dist-na 10.4265 APE10-dist-na 9.7642 APE9-dist-in 6.771 C1008S,Y1011F PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 1.9 0.194 0.226 A 306.0 303.0 0 30 30 0 [[1023, 1292]] 1.0 1ir3 Homo sapiens TYR_INSR_HUMAN TYR 1.4e-96 328.7 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR LCK LCK_HUMAN 1QPCA P06239 231 502 509.0 ANP:904 ATPlike Active DFGin 6.6104 14.4162 BLAminus -133.73, 179.02 58.4, 83.48 -97.79, 21.23 295.19, 99.8 -60.65, -35.99 in-in in 8.7018 Saltbr-in 3.0957 HRD-in -103.01, -49.32 74.3, -4.36 in-in-in SNCiii in-in ActLoopNT-in 2.9208 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.97, 142.08 APE9-dihe-in -126.79, 156.19 APE8-dihe-in -63.13, 117.89 APE8-rot-na 333.56 APE67-dihe-in -65.85, -20.96 -57.94, -43.39 APE12-dist-na 14.8556 APE11-dist-na 10.0047 APE10-dist-na 12.788 APE9-dist-in 6.7844 None PTR394 PTR394 XRAY 1.6 0.2 0.23 A 279.0 272.0 0 29 29 0 [[245, 496]] 1.0 1qpc Homo sapiens TYR_LCK_HUMAN TYR 1.4e-94 322.2 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
TYR MERTK MERTK_HUMAN 2P0CA Q12866 575 861 999.0 ANP:1 ATPlike Inactive DFGin 5.9242 13.1365 BLBplus -137.27, 178.6 60.37, 23.32 -81.61, 167.49 49.71, 91.11 85.65, -47.4 out-none out 13.6493 Saltbr-none 999.0 HRD-in -80.53, -55.62 75.56, -3.56 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 51.71 APE8-rot-na 32.28 APE67-dihe-in -80.87, -2.88 -33.63, -45.94 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.208 0.274 A 313.0 249.0 38 30 12 18 [[587, 856]] 1.0 2p0c Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 2P0CB Q12866 575 861 999.0 ANP:2 ATPlike Inactive DFGin 6.0339 13.3315 BLBplus -140.6, 176.88 63.43, 26.39 -92.68, 153.87 48.18, 81.79 87.34, -0.94 out-none out 13.9733 Saltbr-none 999.0 HRD-in -83.37, -59.67 75.95, 2.32 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.74 APE8-rot-na 27.11 APE67-dihe-in -70.68, -3.16 -43.98, -45.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.208 0.274 B 313.0 248.0 39 30 12 18 [[587, 856]] 1.0 2p0c Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MST1R RON_HUMAN 3PLSA Q04912 1060 1357 1400.0 ANP:1358 ATPlike Inactive DFGin 6.2964 13.4362 BLBplus -158.57, 169.48 54.59, 28.32 -75.35, 163.89 46.83, 88.44 77.37, 8.52 out-out out 14.5017 Saltbr-out 15.6805 HRD-in -64.04, -56.3 78.09, -13.1 out-out-out SNCooo out-out ActLoopNT-out 7.3962 ActLoopCT-out TYR APEdihe_oioai APEdist_aaao APE10-dihe-out -133.31, 27.58 APE9-dihe-in -79.04, 151.37 APE8-dihe-out -60.01, -26.4 APE8-rot-na 344.59 APE67-dihe-in -77.79, -6.02 -43.7, -39.07 APE12-dist-na 21.5297 APE11-dist-na 22.4916 APE10-dist-na 18.0334 APE9-dist-out 10.6231 M1254T None None XRAY 2.24 0.235 0.29 A 298.0 298.0 0 32 32 0 [[1082, 1343]] 1.0 3pls Homo sapiens TYR_MST1R_HUMAN TYR 3.8e-88 301.1 4.0 260.0 257.0 1225 1226 1227 1229 1231 1114 1131 1135 1205 1207 1206 1208.0 1269 1257 1252 1251 1250 1249 1248 1247 1246 1162 Macrophage-stimulating protein receptor
TYR MST1R RON_HUMAN 8ZKDA Q04912 1060 1357 1400.0 ANP:1401 ATPlike Inactive DFGin 5.9634 13.4449 BLBplus -136.42, 163.89 75.82, 17.06 -71.65, 165.79 57.65, 82.07 74.72, 11.98 out-out out 14.7199 Saltbr-out 14.9554 HRD-in -65.95, -60.68 80.92, -14.74 out-out-out SNCooo out-out ActLoopNT-out 7.373 ActLoopCT-out TYR APEdihe_iooai APEdist_aaao APE10-dihe-in -84.37, 161.73 APE9-dihe-out -52.23, -44.7 APE8-dihe-out -56.31, -27.37 APE8-rot-na 334.62 APE67-dihe-in -83.51, -2.98 -41.89, -46.09 APE12-dist-na 22.0591 APE11-dist-na 19.0322 APE10-dist-na 14.2218 APE9-dist-out 10.029 None None None XRAY 2.05 0.18 0.231 A 298.0 298.0 0 32 32 0 [[1082, 1343]] 1.0 8zkd Homo sapiens TYR_MST1R_HUMAN TYR 3.8e-88 301.1 4.0 260.0 257.0 1225 1226 1227 1229 1231 1114 1131 1135 1205 1207 1206 1208.0 1269 1257 1252 1251 1250 1249 1248 1247 1246 1162 Macrophage-stimulating protein receptor
TYR SRC SRC_HUMAN 2SRCA P12931 87 536 536.0 ANP:60001 ATPlike Inactive DFGin 5.9228 13.5972 BLBplus -121.59, 173.63 47.36, 36.7 -81.78, 143.05 40.4, 84.17 86.45, -40.21 out-out out 14.1179 Saltbr-out 13.9285 HRD-in -73.32, -58.33 81.61, -7.89 out-out-out SNCooo out-out ActLoopNT-out 7.5408 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.49, -13.33 APE9-dihe-in -91.46, 129.38 APE8-dihe-in -79.29, 62.74 APE8-rot-na 33.55 APE67-dihe-in -68.18, -15.62 -55.52, -29.75 APE12-dist-na 17.3787 APE11-dist-na 18.7431 APE10-dist-na 13.4547 APE9-dist-out 8.7458 None PTR530 PTR530 XRAY 1.5 0.226 0.281 A 452.0 450.0 0 29 29 0 [[270, 521]] 1.0 2src Homo sapiens TYR_SRC_HUMAN TYR 6.7e-94 320.2 1.0 260.0 260.0 406 407 408 410 412 298 313 317 386 388 387 389.0 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SYK KSYK_HUMAN 4FL1A P43405 363 635 635.0 ANP:701 ATPlike Active DFGin 6.6692 15.0632 BLAminus -122.6, -175.53 56.16, 78.38 -92.62, 24.67 287.04, 93.75 -57.67, -38.36 in-in in 8.0588 Saltbr-in 2.6833 HRD-in -76.27, -50.57 71.77, 3.28 in-in-in SNCiii in-in ActLoopNT-in 2.9759 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.55, 85.11 APE9-dihe-in -99.28, 138.37 APE8-dihe-in -79.64, 69.72 APE8-rot-na 29.68 APE67-dihe-in -60.65, -16.95 -44.16, -41.68 APE12-dist-na 13.8161 APE11-dist-na 10.806 APE10-dist-na 10.4124 APE9-dist-in 7.1318 None None None XRAY 1.79 0.197 0.225 A 291.0 268.0 5 31 31 0 [[370, 628]] 1.0 4fl1 Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4FL3A P43405 9 635 635.0 ANP:701 ATPlike Inactive DFGin 5.2707 12.4112 BLBplus -116.27, 169.06 58.02, 22.77 -60.26, 128.95 39.87, 90.8 70.36, 3.28 out-out out 13.3472 Saltbr-out 12.957 HRD-in -71.66, -54.51 80.39, -19.8 out-out-none SNCoon out-none ActLoopNT-out 7.0299 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 2.25 APE8-rot-na 29.04 APE67-dihe-in -63.72, -20.72 -59.66, -31.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y348F,Y352F None None XRAY 1.9 0.18 0.208 A 635.0 538.0 13 31 18 13 [[370, 628]] 1.0 4fl3 Homo sapiens TYR_SYK_HUMAN TYR 5.1e-89 304.2 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4FL2A P43405 9 635 635.0 ANP:702 ATPlike Inactive DFGin 5.4285 12.3278 BLBplus -115.2, 163.41 55.5, 31.26 -66.72, 128.2 35.56, 90.39 65.72, 13.6 out-out out 13.4906 Saltbr-out 13.2027 HRD-in -70.05, -49.77 75.03, -15.27 out-out-out SNCooo out-out ActLoopNT-out 7.1942 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -115.16, 144.55 APE9-dihe-in -104.91, 94.8 APE8-dihe-out -50.62, -30.17 APE8-rot-na 333.32 APE67-dihe-in -61.99, -18.29 -62.08, -21.97 APE12-dist-na 15.5558 APE11-dist-na 19.2065 APE10-dist-na 15.7365 APE9-dist-out 11.5275 None None None XRAY 2.19 0.184 0.228 A 636.0 555.0 0 31 31 0 [[370, 628]] 1.0 4fl2 Homo sapiens TYR_SYK_HUMAN TYR 5.1e-89 304.2 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR ZAP70 ZAP70_HUMAN 2OZOA P43403 2 606 619.0 ANP:60615 ATPlike Inactive DFGin 5.8971 12.8886 BLAplus -127.72, 179.11 41.99, 48.0 -92.67, 86.43 47.29, 92.46 138.54, -47.19 out-out out 14.1822 Saltbr-out 12.4812 HRD-in -87.29, -57.15 80.94, -19.73 out-out-out SNCooo out-out ActLoopNT-out 7.5295 ActLoopCT-out TYR APEdihe_nnnao APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 93.52 APE8-rot-na 331.14 APE67-dihe-out -88.9, 16.07 -148.01, 51.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y315F,Y319F,D461N None None XRAY 2.6 0.26 0.29 A 613.0 538.0 14 31 17 14 [[338, 595]] 1.0 2ozo Homo sapiens TYR_ZAP70_HUMAN TYR 8.5e-89 303.4 6.0 259.0 254.0 478 479 480 482 484 369 386 390 458 460 459 461.0 521 509 504 503 502 501 500 499 498 415 Tyrosine-protein kinase ZAP-70
TYR ZAP70 ZAP70_HUMAN 4K2RA P43403 2 606 619.0 ANP:60702 ATPlike Inactive DFGin 5.9276 12.4383 BLAplus -138.85, 178.0 51.18, 49.01 -84.24, -35.32 31.27, 105.54 -104.96, 20.24 out-out out 14.1129 Saltbr-out 13.9854 HRD-out -89.83, 129.13 -108.05, -14.5 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -15.2 APE8-dihe-out -67.79, 10.24 APE8-rot-na 350.79 APE67-dihe-in -82.13, -29.45 -101.33, 20.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 12.2697 D461N None None XRAY 3.0 0.213 0.287 A 614.0 543.0 17 31 14 17 [[338, 595]] 1.0 4k2r Homo sapiens TYR_ZAP70_HUMAN TYR 8.6e-89 303.4 6.0 259.0 254.0 478 479 480 482 484 369 386 390 458 460 459 461.0 521 509 504 503 502 501 500 499 498 415 Tyrosine-protein kinase ZAP-70
OTHER LPL0262 Q5WZW9_LEGPL 5CKWA Q5WZW9 15 404 961.0 ANP:60501 ATPlike Active DFGin 5.9476 12.719 BLAminus -133.44, 169.43 70.28, 94.79 -117.83, 12.87 299.33, 117.8 -55.88, -8.97 in-in in 6.7101 Saltbr-in 2.7162 HRD-naQ -80.53, -48.66 73.11, 5.26 in-in-in SNCiii in-in ActLoopNT-in 2.9268 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -69.26, -22.18 APE9-dihe-na -101.55, 179.41 APE8-dihe-in -117.11, 122.15 APE8-rot-in 302.21 APE67-dihe-in -64.67, -9.61 -57.44, -37.84 APE12-dist-in 11.7619 APE11-dist-in 9.7088 APE10-dist-in 4.6475 APE9-dist-in 3.3467 None None None XRAY 2.49 0.207 0.258 A 451.0 378.0 5 25 25 0 [[75, 309]] 1.0 5ckw Legionella pneumophila OTHER_LPL0262_LEGPL NEK 4.8e-15 62.8 10.0 222.0 213.0 212 213 214 216 218 104 119 123 192 194 193 195.0 249 237 232 231 230 229 228 227 226 146 non-specific serine/threonine protein kinase
OTHER LPL0262 Q5WZW9_LEGPL 5CKWB Q5WZW9 1 404 961.0 ANP:60501 ATPlike Active DFGin 6.1888 12.6735 BLAminus -144.06, 165.73 65.65, 85.18 -109.61, 21.73 306.46, 113.14 -57.87, -17.2 in-in in 6.7686 Saltbr-in 2.8816 HRD-naQ -82.05, -45.94 73.24, -7.24 in-in-in SNCiii in-in ActLoopNT-in 2.9759 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -76.56, -19.65 APE9-dihe-na -103.71, -175.8 APE8-dihe-in -130.62, 116.65 APE8-rot-in 293.03 APE67-dihe-in -65.48, -28.87 -48.06, -39.07 APE12-dist-in 11.5294 APE11-dist-in 9.5863 APE10-dist-in 4.4834 APE9-dist-in 3.4581 None None None XRAY 2.49 0.207 0.258 B 451.0 399.0 5 25 25 0 [[75, 309]] 1.0 5ckw Legionella pneumophila OTHER_LPL0262_LEGPL NEK 4.8e-15 62.8 10.0 222.0 213.0 212 213 214 216 218 104 119 123 192 194 193 195.0 249 237 232 231 230 229 228 227 226 146 non-specific serine/threonine protein kinase
CMGC MAPK A0A3Q8ITZ9_LEIDO 4QNYA A0A3Q8ITZ9 4 350 408.0 ANP:402 ATPlike Inactive DFGin 6.1648 14.7035 BLAminus -127.76, -174.94 61.93, 78.26 -95.74, 34.98 293.98, 91.09 -76.44, -18.02 in-in in 9.3477 Saltbr-in 2.7287 HRD-in -68.82, -45.36 71.54, -13.83 in-in-out SNCiio in-out ActLoopNT-in 2.7408 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oooo APE10-dihe-na -132.18, 155.62 APE9-dihe-na -94.67, -21.05 APE8-dihe-in -141.24, 100.95 APE8-rot-na 183.02 APE67-dihe-in -68.06, -10.3 -112.98, 4.12 APE12-dist-out 16.0225 APE11-dist-out 14.6699 APE10-dist-out 11.6896 APE9-dist-out 12.5673 None None None XRAY 2.257 0.237 0.285 A 354.0 333.0 3 28 25 3 [[21, 310]] 1.0 4qny Leishmania donovani CMGC_MAPK_LEIDO CMGC 5.8e-75 258.3 3.0 301.0 299.0 166 167 168 170 172 51 70 74 146 148 147 149.0 207 194 189 188 187 186 185 184 183 105 Mitogen activated protein kinase, putative
CMGC MAPK A0A3Q8ITZ9_LEIDO 4QNYB A0A3Q8ITZ9 4 350 408.0 ANP:403 ATPlike Inactive DFGin 6.1377 14.7888 BLAminus -126.8, -176.12 61.38, 78.86 -95.33, 36.88 294.2, 91.77 -77.29, -21.88 in-in in 9.4534 Saltbr-in 2.8308 HRD-in -69.33, -48.45 68.04, -9.32 in-in-out SNCiio in-out ActLoopNT-in 2.5807 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oooo APE10-dihe-na -133.75, 152.71 APE9-dihe-na -90.5, -19.94 APE8-dihe-in -141.35, 99.54 APE8-rot-na 186.55 APE67-dihe-in -67.94, -11.27 -112.59, 3.99 APE12-dist-out 16.1485 APE11-dist-out 14.7495 APE10-dist-out 11.6845 APE9-dist-out 12.6418 None None None XRAY 2.257 0.237 0.285 B 354.0 339.0 2 28 26 2 [[21, 310]] 1.0 4qny Leishmania donovani CMGC_MAPK_LEIDO CMGC 5.8e-75 258.3 3.0 301.0 299.0 166 167 168 170 172 51 70 74 146 148 147 149.0 207 194 189 188 187 186 185 184 183 105 Mitogen activated protein kinase, putative
TKL LYK3 LYK3_MEDTR 9GFZA Q6UD73 302 596 620.0 ANP:601 ATPlike Inactive DFGin 5.8955 16.3194 BLBtrans -112.0, 159.57 61.3, 42.0 -77.09, 135.77 153.85, 71.13 82.14, -2.66 out-out out 14.7946 Saltbr-out 16.343 HRD-in -69.33, -37.57 70.07, -2.36 out-out-out SNCooo out-out ActLoopNT-out 6.107 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -140.09, 130.62 APE9-dihe-na 119.67, 164.52 APE8-dihe-in -118.67, 135.65 APE8-rot-in 301.27 APE67-dihe-inflip 89.4, -18.92 -56.77, 138.93 APE12-dist-out 14.646 APE11-dist-in 13.0792 APE10-dist-out 9.1944 APE9-dist-in 4.3087 D459N None None XRAY 2.5 0.211 0.257 A 296.0 288.0 7 29 25 4 [[321, 594]] 1.0 9gfz Medicago truncatula TKL_LYK3_MEDTR TKL 3.5e-59 206.5 3.0 264.0 262.0 458 459 460 462 464 349 362 366 438 440 439 441.0 499 487 482 481 480 479 478 477 476 391 LysM domain receptor-like kinase 3
TKL LYR4 G7K7K0_MEDTR 8PS7B G7K7K0 340 636 660.0 ANP:703 ATPlike Pseudo DFGin 7.7676 15.0657 BLBminus -155.57, -174.44 55.36, 56.3 -70.81, 152.24 289.97, 66.8 93.85, 156.74 out-out out 15.9615 Saltbr-out 14.036 HRD-in -57.6, -55.05 79.6, -10.79 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -72.46, -42.72 APE9-dihe-na -56.2, -52.66 APE8-dihe-out -56.27, -29.69 APE8-rot-out 59.05 APE67-dihe-in -100.31, -14.89 -66.25, -40.12 APE12-dist-in 9.7023 APE11-dist-in 13.6472 APE10-dist-out 15.2433 APE9-dist-out 9.612 None None None XRAY 2.1 0.225 0.269 B 297.0 274.0 23 33 21 12 [[360, 633]] 1.0 8ps7 Medicago truncatula TKL_LYR4_MEDTR TKL 4.9e-53 186.3 13.0 266.0 254.0 493 494 495 497 499 379 388 392 473 475 474 476.0 538 526 521 520 519 518 517 516 515 418 LysM-domain receptor-like kinase
TKL LYR4 G7K7K0_MEDTR 8PS7A G7K7K0 340 636 660.0 ANP:704 ATPlike Pseudo DFGin 7.3438 12.4911 None -132.7, -71.23 -80.99, 65.77 -101.31, -4.53 43.9, 75.68 -166.17, 141.69 out-out out 12.6635 Saltbr-out 13.161 HRD-in -67.54, -63.16 83.85, -10.66 out-out-out SNCooo out-out ActLoopNT-out 9.632 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -64.12, -49.62 APE9-dihe-na -62.67, -34.57 APE8-dihe-out -58.19, -50.78 APE8-rot-in 276.77 APE67-dihe-in -82.12, -28.85 -67.98, -32.83 APE12-dist-out 14.2466 APE11-dist-out 19.2311 APE10-dist-out 20.4004 APE9-dist-out 9.2958 None None None XRAY 2.1 0.225 0.269 A 297.0 279.0 18 33 33 0 [[360, 633]] 1.0 8ps7 Medicago truncatula TKL_LYR4_MEDTR TKL 4.9e-53 186.3 13.0 266.0 254.0 493 494 495 497 499 379 388 392 473 475 474 476.0 538 526 521 520 519 518 517 516 515 418 LysM-domain receptor-like kinase
OTHER BUD32 KAE1B_METJA 2VWBA Q58530 1 530 535.0 ANP:1531 Allosteric Inactive DFGin 6.8437 17.1317 None -120.64, -3.56 -136.03, 137.71 -148.58, 37.82 232.34, 113.93 -66.32, -14.47 in-in in 7.9752 Saltbr-in 2.7284 HRD-out -83.04, 140.14 -107.29, 16.57 in-in-na SNCiia in-na ActLoopNT-in 2.9164 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -66.96, -33.04 APE9-dihe-na -68.59, -42.86 APE8-dihe-na -73.15, -19.01 APE8-rot-na 294.55 APE67-dihe-na -59.99, -36.61 -63.88, -52.94 APE12-dist-na 17.0179 APE11-dist-na 12.319 APE10-dist-na 14.9692 APE9-dist-na 11.6624 None None None XRAY 3.05 0.224 0.301 A 535.0 519.0 4 23 23 0 [[334, 534]] 1.0 2vwb Methanocaldococcus jannaschii OTHER_BUD32_METJA TP53RK 8.5e-45 159.9 6.0 218.0 213.0 466 467 468 470 472 360 384 388 448 450 449 451.0 483 489 484 483 482 481 480 479 478 414 Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
OTHER BUD32 KAE1B_METJA 2VWBB Q58530 1 532 535.0 ANP:1533 Allosteric Inactive DFGin 6.5797 16.7156 None -128.01, -5.24 -139.71, 160.08 -157.9, 25.33 238.13, 113.59 -41.68, -37.13 in-in in 7.8464 Saltbr-in 3.1753 HRD-out -90.81, 128.03 -91.65, 20.67 in-in-na SNCiia in-na ActLoopNT-in 2.657 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -74.1, -29.36 APE9-dihe-na -76.07, -42.12 APE8-dihe-na -69.9, -15.57 APE8-rot-na 312.74 APE67-dihe-na -42.13, -37.17 -74.66, -63.72 APE12-dist-na 16.6492 APE11-dist-na 12.1119 APE10-dist-na 14.818 APE9-dist-na 11.4755 None None None XRAY 3.05 0.224 0.301 B 535.0 507.0 8 23 23 0 [[334, 534]] 1.0 2vwb Methanocaldococcus jannaschii OTHER_BUD32_METJA TP53RK 8.5e-45 159.9 6.0 218.0 213.0 466 467 468 470 472 360 384 388 448 450 449 451.0 483 489 484 483 482 481 480 479 478 414 Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
OTHER STT7 C1EBN1_MICCC 4IX5A C1EBN1 151 489 489.0 ANP:60603 none Inactive None 999.0 999.0 None -120.9, 168.56 71.67, 80.19 -91.21, 21.79 297.99, 161.42 -64.36, -22.18 none-na none 999.0 Saltbr-na 999.0 HRD-na- -71.12, -47.17 73.28, 1.59 na-in-none SNCain in-none ActLoopNT-in 2.9126 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.178 0.201 A 350.0 339.0 0 -337 -337 0 [[62, 488]] 1.0 4ix5 Micromonas commoda OTHER_STT7_MICCC CMGC 1.3e-08 61.8 104.0 156.0 81.0 337 338 339 341 343 0 0 0 315 317 316 318.0 0 0 0 0 0 0 0 0 0 0 Protein kinase domain-containing protein
OTHER STT7 C1EBN1_MICCC 4IX5B C1EBN1 151 489 489.0 ANP:60602 none Inactive None 999.0 999.0 None -122.9, 169.14 69.98, 79.33 -89.65, 21.35 295.31, 157.7 -65.22, -20.9 none-na none 999.0 Saltbr-na 999.0 HRD-na- -70.35, -44.14 70.61, 3.11 na-in-none SNCain in-none ActLoopNT-in 2.9407 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.178 0.201 B 350.0 339.0 0 -337 -337 0 [[62, 488]] 1.0 4ix5 Micromonas commoda OTHER_STT7_MICCC CMGC 1.3e-08 61.8 104.0 156.0 81.0 337 338 339 341 343 0 0 0 315 317 316 318.0 0 0 0 0 0 0 0 0 0 0 Protein kinase domain-containing protein
AGC PRKACA KAPCA_MOUSE 6MM6C P05132 19 351 351.0 ANP:60402 ATPlike Inactive DFGin 6.7799 16.0821 ABAminus -110.74, -8.1 -141.78, 125.75 -126.67, 17.79 291.81, 81.75 -52.6, -43.19 out-out out 10.4027 Saltbr-out 4.4909 HRD-in -64.73, -48.52 44.91, 28.18 out-in-out SNCoio in-out ActLoopNT-in 2.8769 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -155.16, 154.51 APE9-dihe-na 131.73, -155.42 APE8-dihe-in -119.09, 141.73 APE8-rot-out 198.33 APE67-dihe-in -57.79, -26.12 -45.84, -50.95 APE12-dist-in 8.5303 APE11-dist-in 11.8147 APE10-dist-in 6.3058 APE9-dist-in 4.5025 None TPO198,SEP339 TPO198,SEP339 XRAY 2.39 0.225 0.261 C 339.0 322.0 0 25 25 0 [[44, 298]] 1.0 6mm6 Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 6MM6E P05132 19 351 351.0 ANP:60401 ATPlike Inactive DFGin 6.7325 15.9653 ABAminus -112.26, -9.59 -137.74, 126.1 -127.73, 18.87 290.52, 82.39 -53.04, -44.19 out-out out 10.2709 Saltbr-out 5.278 HRD-in -66.74, -47.88 44.41, 27.02 out-in-out SNCoio in-out ActLoopNT-in 2.8731 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -157.27, 155.34 APE9-dihe-na 128.78, -154.8 APE8-dihe-in -120.26, 141.99 APE8-rot-out 197.33 APE67-dihe-in -57.79, -26.44 -45.46, -51.33 APE12-dist-in 8.4779 APE11-dist-in 11.8514 APE10-dist-in 6.3306 APE9-dist-in 4.4228 None TPO198,SEP339 TPO198,SEP339 XRAY 2.39 0.225 0.261 E 339.0 320.0 0 25 25 0 [[44, 298]] 1.0 6mm6 Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 6MM7A P05132 17 351 351.0 ANP:60406 ATPlike Inactive DFGin 6.7159 15.4284 ABAminus -112.23, -9.6 -137.01, 123.03 -130.15, 19.3 297.15, 81.39 -54.86, -42.58 out-out out 10.2821 Saltbr-out 4.6231 HRD-in -76.47, -53.66 52.13, 28.38 out-in-out SNCoio in-out ActLoopNT-in 2.8634 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -163.99, 161.65 APE9-dihe-na 126.52, -159.69 APE8-dihe-in -119.22, 141.71 APE8-rot-out 195.45 APE67-dihe-in -67.85, -20.3 -44.24, -48.26 APE12-dist-in 8.2035 APE11-dist-in 11.1251 APE10-dist-in 5.7383 APE9-dist-in 3.9708 None TPO198,SEP339 TPO198,SEP339 XRAY 1.85 0.213 0.238 A 339.0 327.0 0 25 25 0 [[44, 298]] 1.0 6mm7 Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 6MM7D P05132 16 351 351.0 ANP:60405 ATPlike Inactive DFGin 6.6517 15.4584 ABAminus -113.01, -9.74 -137.13, 123.49 -128.55, 17.46 296.74, 82.18 -52.99, -42.79 out-out out 10.3794 Saltbr-out 5.8168 HRD-in -73.81, -53.25 53.83, 26.23 out-in-out SNCoio in-out ActLoopNT-in 2.8742 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -166.02, 161.72 APE9-dihe-na 122.21, -160.7 APE8-dihe-in -119.01, 142.81 APE8-rot-out 192.42 APE67-dihe-in -67.72, -20.93 -42.31, -48.3 APE12-dist-in 8.2101 APE11-dist-in 11.2017 APE10-dist-in 5.7858 APE9-dist-in 3.9614 None TPO198,SEP339 TPO198,SEP339 XRAY 1.85 0.213 0.238 D 339.0 324.0 0 25 25 0 [[44, 298]] 1.0 6mm7 Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 6MM8C P05132 16 351 351.0 ANP:60403 ATPlike Inactive DFGin 6.6132 15.2001 ABAminus -113.8, -10.95 -132.36, 129.54 -134.0, 24.39 301.03, 83.83 -57.02, -38.35 out-out out 10.3401 Saltbr-out 7.3235 HRD-in -73.54, -53.96 54.41, 29.61 out-in-out SNCoio in-out ActLoopNT-in 2.7764 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -159.79, 167.54 APE9-dihe-na 115.95, -161.99 APE8-dihe-in -118.41, 142.14 APE8-rot-out 195.18 APE67-dihe-in -66.48, -19.98 -46.61, -45.65 APE12-dist-in 8.1252 APE11-dist-in 11.2017 APE10-dist-in 5.8341 APE9-dist-in 3.9965 None TPO198,SEP339 TPO198,SEP339 XRAY 1.85 0.183 0.221 C 339.0 325.0 0 25 25 0 [[44, 298]] 1.0 6mm8 Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 8UKND P05132 16 351 351.0 ANP:60400 ATPlike Inactive DFGin 6.6105 14.9582 ABAminus -121.75, -47.3 -93.55, 119.31 -121.12, 22.25 288.77, 83.91 -60.17, -43.74 in-out in 9.6363 Saltbr-out 4.003 HRD-in -71.48, -47.99 39.7, 38.93 out-in-in SNCoii in-in ActLoopNT-in 2.9756 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.1, 161.55 APE9-dihe-na 104.53, 169.82 APE8-dihe-in -72.88, 137.25 APE8-rot-in 280.42 APE67-dihe-in -60.56, -25.71 -55.68, -37.9 APE12-dist-in 8.0946 APE11-dist-in 11.2355 APE10-dist-in 5.8091 APE9-dist-in 4.6921 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.75 0.197 0.232 D 339.0 323.0 0 25 25 0 [[44, 298]] 1.0 8ukn Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 8UKOE P05132 16 351 351.0 ANP:60403 ATPlike Inactive DFGin 6.0364 14.5957 ABAminus -122.57, -57.22 -79.99, 109.96 -108.47, 33.73 286.2, 84.93 -64.54, -41.62 in-in in 9.7403 Saltbr-in 3.5644 HRD-in -78.91, -48.33 66.16, 13.52 in-in-in SNCiii in-in ActLoopNT-in 2.8677 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.15, 159.43 APE9-dihe-na 137.57, -133.12 APE8-dihe-in -144.28, 132.68 APE8-rot-in 289.09 APE67-dihe-in -62.87, -18.89 -48.53, -47.79 APE12-dist-in 8.0799 APE11-dist-in 11.3212 APE10-dist-in 5.8296 APE9-dist-in 3.774 None TPO198,SEP339 TPO198,SEP339 XRAY 2.89 0.213 0.259 E 339.0 336.0 0 25 25 0 [[44, 298]] 1.0 8uko Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 8UKPE P05132 17 351 351.0 ANP:60402 ATPlike Inactive DFGin 6.1336 14.4301 ABAminus -106.11, -56.02 -81.74, 124.54 -123.06, 18.4 279.21, 82.41 -57.4, -55.55 in-out in 9.2794 Saltbr-out 4.1807 HRD-in -89.57, -52.98 66.95, 19.28 out-in-in SNCoii in-in ActLoopNT-in 2.9525 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.29, 147.38 APE9-dihe-na 136.74, -150.06 APE8-dihe-in -126.21, 134.43 APE8-rot-in 318.02 APE67-dihe-in -77.56, -4.79 -54.58, -35.83 APE12-dist-in 7.9285 APE11-dist-in 10.8204 APE10-dist-in 5.1851 APE9-dist-in 3.8514 None SEP140,TPO198 SEP140,TPO198 XRAY 2.85 0.242 0.281 E 339.0 323.0 0 25 25 0 [[44, 298]] 1.0 8ukp Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 7E11A P05132 14 351 351.0 ANP:60401 ATPlike Active DFGin 6.205 14.4514 BLAminus -127.38, -169.19 58.28, 74.22 -96.53, 30.74 276.22, 81.09 -66.46, -21.72 in-in in 9.0533 Saltbr-in 2.5511 HRD-in -91.79, -53.23 62.57, 24.02 in-in-in SNCiii in-in ActLoopNT-in 3.1289 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.39, 155.98 APE9-dihe-na 134.96, -158.62 APE8-dihe-in -113.95, 132.34 APE8-rot-in 301.67 APE67-dihe-in -76.79, -1.28 -53.37, -39.68 APE12-dist-in 8.3091 APE11-dist-in 11.1349 APE10-dist-in 5.7098 APE9-dist-in 3.659 None TPO198,SEP339 TPO198,SEP339 XRAY 3.43 0.262 0.317 A 338.0 337.0 0 25 25 0 [[44, 298]] 1.0 7e11 Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 6MM5E P05132 16 351 351.0 ANP:60402 ATPlike Inactive DFGin 5.9604 14.3509 BLAminus -116.65, 159.11 76.02, 91.05 -92.83, 26.22 286.06, 88.09 -52.81, -36.86 in-in in 8.8493 Saltbr-in 2.8003 HRD-in -83.15, -50.88 72.11, -0.72 in-in-out SNCiio in-out ActLoopNT-in 2.8706 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -156.6, 159.33 APE9-dihe-na 129.67, -150.44 APE8-dihe-in -128.62, 141.57 APE8-rot-out 194.03 APE67-dihe-in -68.05, -20.18 -46.89, -45.89 APE12-dist-in 8.2074 APE11-dist-in 11.3781 APE10-dist-in 5.7976 APE9-dist-in 3.7765 None TPO198,SEP339 TPO198,SEP339 XRAY 1.95 0.183 0.227 E 339.0 336.0 0 25 25 0 [[44, 298]] 1.0 6mm5 Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3PVBA P05132 7 351 351.0 ANP:60400 ATPlike Active DFGin 5.2614 14.1066 BLAminus -138.85, 171.16 63.11, 82.89 -89.43, -59.95 273.17, 54.43 27.14, -66.26 in-in in 8.6853 Saltbr-in 3.4757 HRD-in -84.36, -35.8 62.24, -18.82 in-in-in SNCiii in-in ActLoopNT-in 3.2175 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -177.84, 157.88 APE9-dihe-na 132.55, -154.74 APE8-dihe-in -122.19, 108.01 APE8-rot-in 318.81 APE67-dihe-in -60.75, -2.24 -13.41, -60.33 APE12-dist-in 7.7331 APE11-dist-in 10.5794 APE10-dist-in 5.5109 APE9-dist-in 4.0421 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 3.3 0.242 0.29 A 345.0 345.0 0 25 25 0 [[44, 298]] 1.0 3pvb Mus musculus AGC_PRKACA_MOUSE AGC 1.4e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 2QCSA P05132 14 351 351.0 ANP:60400 ATPlike Active DFGin 5.648 14.2907 BLAminus -119.78, 176.88 65.56, 77.31 -85.05, 19.39 273.35, 51.28 -44.32, -42.51 in-in in 8.7843 Saltbr-in 2.6377 HRD-in -93.14, -54.78 73.52, 10.18 in-in-in SNCiii in-in ActLoopNT-in 2.7354 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.52, 149.74 APE9-dihe-na 148.64, -142.53 APE8-dihe-in -132.36, 132.12 APE8-rot-in 297.18 APE67-dihe-in -64.67, -25.45 -36.74, -53.73 APE12-dist-in 8.133 APE11-dist-in 11.3207 APE10-dist-in 5.8515 APE9-dist-in 3.5726 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.2 0.194 0.225 A 350.0 338.0 0 25 25 0 [[44, 298]] 1.0 2qcs Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3IDBA P05132 9 351 351.0 ANP:60450 ATPlike Active DFGin 5.3459 14.4126 BLAminus -121.17, -175.1 59.7, 79.28 -94.34, 24.01 267.69, 48.22 -48.56, -33.02 in-in in 8.8455 Saltbr-in 2.694 HRD-in -80.07, -50.75 69.18, 11.1 in-in-in SNCiii in-in ActLoopNT-in 2.9896 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.99, 160.5 APE9-dihe-na 138.4, -150.07 APE8-dihe-in -124.64, 132.33 APE8-rot-in 296.41 APE67-dihe-in -59.26, -21.93 -30.94, -63.4 APE12-dist-in 8.1019 APE11-dist-in 11.5726 APE10-dist-in 6.0684 APE9-dist-in 3.4448 None TPO198,SEP339 TPO198,SEP339 XRAY 1.62 0.206 0.23 A 350.0 343.0 0 25 25 0 [[44, 298]] 1.0 3idb Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3IDCA P05132 9 351 351.0 ANP:60450 ATPlike Active DFGin 5.079 14.4716 BLAminus -127.31, 174.57 68.22, 96.34 -111.15, 30.11 265.57, 49.45 -62.75, -22.0 in-in in 8.6423 Saltbr-in 3.0306 HRD-in -69.04, -44.03 64.09, 13.38 in-in-in SNCiii in-in ActLoopNT-in 2.8561 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.35, 157.69 APE9-dihe-na 142.7, -132.16 APE8-dihe-in -139.58, 115.88 APE8-rot-in 293.03 APE67-dihe-in -54.66, -5.54 -16.73, -78.3 APE12-dist-in 7.8437 APE11-dist-in 11.3725 APE10-dist-in 6.1644 APE9-dist-in 3.6752 None TPO198,SEP339 TPO198,SEP339 XRAY 2.7 0.241 0.319 A 350.0 343.0 0 25 25 0 [[44, 298]] 1.0 3idc Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DG0E P05132 11 351 351.0 ANP:60402 ATPlike Active DFGin 5.5834 14.3418 BLAminus -118.87, 179.66 65.44, 79.89 -93.34, 25.25 272.35, 58.42 -52.71, -36.39 in-in in 8.955 Saltbr-in 2.6989 HRD-in -84.35, -52.45 74.02, 7.32 in-in-in SNCiii in-in ActLoopNT-in 2.8946 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.07, 161.1 APE9-dihe-na 130.81, -146.6 APE8-dihe-in -130.07, 130.32 APE8-rot-in 303.85 APE67-dihe-in -61.09, -22.5 -44.14, -49.24 APE12-dist-in 8.0079 APE11-dist-in 11.4975 APE10-dist-in 5.8998 APE9-dist-in 3.3886 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.0 0.196 0.228 E 350.0 341.0 0 25 25 0 [[44, 298]] 1.0 4dg0 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DH7A P05132 16 351 351.0 ANP:60403 ATPlike Active DFGin 5.5738 14.3492 BLAminus -124.43, -175.45 59.33, 78.79 -93.54, 24.71 270.97, 54.79 -50.12, -38.03 in-in in 9.0247 Saltbr-in 2.7242 HRD-in -76.49, -50.79 66.5, 11.01 in-in-in SNCiii in-in ActLoopNT-in 2.9607 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.18, 162.39 APE9-dihe-na 131.3, -151.54 APE8-dihe-in -126.44, 134.15 APE8-rot-in 300.19 APE67-dihe-in -56.38, -25.77 -37.48, -60.34 APE12-dist-in 8.0928 APE11-dist-in 11.4546 APE10-dist-in 5.87 APE9-dist-in 3.4166 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.8 0.179 0.194 A 350.0 336.0 0 25 25 0 [[44, 298]] 1.0 4dh7 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DH8A P05132 16 351 351.0 ANP:60403 ATPlike Active DFGin 5.9006 14.014 BLAminus -123.95, -176.77 59.01, 85.18 -98.8, 24.84 279.52, 63.26 -51.76, -30.5 in-in in 8.8003 Saltbr-in 2.7128 HRD-in -77.99, -56.65 70.43, 3.78 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.95, 158.57 APE9-dihe-na 135.16, -154.79 APE8-dihe-in -124.8, 132.89 APE8-rot-in 296.53 APE67-dihe-in -58.95, -25.2 -38.46, -56.52 APE12-dist-in 8.1451 APE11-dist-in 11.4751 APE10-dist-in 5.904 APE9-dist-in 3.5115 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.3 0.155 0.188 A 350.0 336.0 0 25 25 0 [[44, 298]] 1.0 4dh8 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4HPTE P05132 15 351 351.0 ANP:60401 ATPlike Active DFGin 5.7482 14.4242 BLAminus -115.4, 178.03 67.73, 81.09 -92.11, 21.69 273.09, 55.37 -58.71, -29.4 in-in in 9.0532 Saltbr-in 2.6604 HRD-in -90.64, -54.09 71.81, 9.39 in-in-in SNCiii in-in ActLoopNT-in 2.8739 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.27, 162.98 APE9-dihe-na 129.56, -147.32 APE8-dihe-in -127.39, 129.92 APE8-rot-in 299.02 APE67-dihe-in -63.31, -27.9 -40.61, -49.36 APE12-dist-in 8.0686 APE11-dist-in 11.3854 APE10-dist-in 5.8255 APE9-dist-in 3.5734 None TPO198,SEP339 TPO198,SEP339 XRAY 2.15 0.189 0.228 E 350.0 337.0 0 25 25 0 [[44, 298]] 1.0 4hpt Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4HPUE P05132 13 351 351.0 ANP:60402 ATPlike Active DFGin 5.5508 14.4067 BLAminus -117.63, -178.61 63.83, 78.8 -92.22, 24.46 271.46, 55.23 -53.69, -32.94 in-in in 9.0306 Saltbr-in 2.6916 HRD-in -87.73, -52.35 74.85, 8.01 in-in-in SNCiii in-in ActLoopNT-in 2.9145 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.41, 162.17 APE9-dihe-na 134.1, -149.11 APE8-dihe-in -128.69, 136.04 APE8-rot-in 297.56 APE67-dihe-in -58.67, -24.48 -48.3, -49.81 APE12-dist-in 8.0634 APE11-dist-in 11.5067 APE10-dist-in 5.8865 APE9-dist-in 3.4033 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.55 0.173 0.194 E 350.0 339.0 0 25 25 0 [[44, 298]] 1.0 4hpu Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DFXE P05132 2 351 351.0 ANP:60402 ATPlike Active DFGin 5.5242 14.2861 BLAminus -116.71, -179.39 66.13, 78.01 -91.08, 23.34 272.63, 51.46 -56.59, -32.27 in-in in 8.8728 Saltbr-in 2.7287 HRD-in -88.99, -54.58 73.79, 11.03 in-in-in SNCiii in-in ActLoopNT-in 2.9336 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.69, 159.64 APE9-dihe-na 138.16, -148.52 APE8-dihe-in -130.4, 136.32 APE8-rot-in 296.63 APE67-dihe-in -59.91, -24.0 -47.38, -49.37 APE12-dist-in 8.0462 APE11-dist-in 11.4097 APE10-dist-in 5.8188 APE9-dist-in 3.3923 K8C SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.35 0.157 0.179 E 350.0 350.0 0 25 25 0 [[44, 298]] 1.0 4dfx Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4XW4A P05132 15 351 351.0 ANP:60403 ATPlike Active DFGin 5.673 14.5624 BLAminus -117.82, -177.44 65.15, 79.34 -92.69, 26.58 269.45, 57.64 -61.99, -28.36 in-in in 8.9306 Saltbr-in 2.8579 HRD-in -86.05, -50.94 67.2, 15.72 in-in-in SNCiii in-in ActLoopNT-in 3.0139 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.62, 159.69 APE9-dihe-na 135.12, -140.29 APE8-dihe-in -136.84, 125.12 APE8-rot-in 301.75 APE67-dihe-in -61.52, -26.6 -45.5, -44.66 APE12-dist-in 7.961 APE11-dist-in 11.4188 APE10-dist-in 5.9353 APE9-dist-in 3.6644 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.82 0.183 0.24 A 356.0 337.0 0 25 25 0 [[44, 298]] 1.0 4xw4 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 7E0ZA P05132 14 351 351.0 ANP:60401 ATPlike Active DFGin 5.5662 13.8842 BLAminus -118.85, -174.47 59.93, 79.47 -94.43, 25.89 275.59, 63.85 -59.78, -31.6 in-in in 8.6241 Saltbr-in 2.9777 HRD-in -96.8, -56.38 78.26, 13.74 in-in-in SNCiii in-in ActLoopNT-in 2.9292 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.91, 162.74 APE9-dihe-na 131.67, -149.57 APE8-dihe-in -131.04, 130.65 APE8-rot-in 294.41 APE67-dihe-in -63.42, -12.5 -45.48, -52.1 APE12-dist-in 7.8999 APE11-dist-in 11.1823 APE10-dist-in 5.721 APE9-dist-in 3.4 None TPO198,SEP339 TPO198,SEP339 XRAY 2.162 0.184 0.228 A 358.0 337.0 0 25 25 0 [[44, 298]] 1.0 7e0z Mus musculus AGC_PRKACA_MOUSE AGC 1.6e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 7E12A P05132 19 351 351.0 ANP:60401 ATPlike Inactive DFGin 5.3957 14.6175 BLAminus -131.26, -169.7 58.92, 77.12 -93.02, 37.73 266.27, 47.03 -71.49, -23.13 in-in in 8.8067 Saltbr-in 3.2657 HRD-out -127.04, 103.44 -105.61, 37.91 in-in-in SNCiii in-in ActLoopNT-in 2.903 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.78, 159.74 APE9-dihe-na 134.39, -158.49 APE8-dihe-in -118.85, 128.69 APE8-rot-in 308.98 APE67-dihe-in -63.3, -26.53 -50.37, -37.69 APE12-dist-in 8.03 APE11-dist-in 11.3719 APE10-dist-in 5.9651 APE9-dist-in 3.4216 None TPO198,SEP339 TPO198,SEP339 XRAY 2.796 0.208 0.252 A 358.0 333.0 0 25 25 0 [[44, 298]] 1.0 7e12 Mus musculus AGC_PRKACA_MOUSE AGC 1.6e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DG3E P05132 15 351 351.0 ANP:60401 ATPlike Active DFGin 5.4812 14.3421 BLAminus -115.99, -176.62 61.62, 77.98 -90.25, 24.84 270.29, 54.4 -55.44, -35.73 in-in in 8.842 Saltbr-in 2.6947 HRD-in -87.1, -53.93 73.82, 10.76 in-in-in SNCiii in-in ActLoopNT-in 2.8817 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.46, 161.61 APE9-dihe-na 135.41, -150.07 APE8-dihe-in -129.52, 135.22 APE8-rot-in 300.3 APE67-dihe-in -58.11, -23.91 -46.28, -51.67 APE12-dist-in 8.1435 APE11-dist-in 11.4816 APE10-dist-in 5.8864 APE9-dist-in 3.4048 R337A SEP140,TPO198 SEP140,TPO198 XRAY 1.8 0.185 0.217 E 371.0 337.0 0 25 25 0 [[44, 298]] 1.0 4dg3 Mus musculus AGC_PRKACA_MOUSE AGC 1.8e-94 321.8 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3O7LB P05132 18 351 351.0 ANP:60354 ATPlike Inactive DFGin 5.7904 14.6658 BLAminus -108.29, -170.95 57.63, 74.91 -94.92, 22.34 267.93, 64.07 -48.2, -34.6 in-in in 9.0975 Saltbr-in 2.9978 HRD-in -84.13, -53.04 68.25, 25.66 in-in-out SNCiio in-out ActLoopNT-in 2.9497 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -140.78, 178.73 APE9-dihe-na 123.03, -156.78 APE8-dihe-in -134.79, 129.02 APE8-rot-out 131.03 APE67-dihe-in -64.87, -13.33 -37.09, -52.44 APE12-dist-in 8.1152 APE11-dist-in 11.126 APE10-dist-in 5.5927 APE9-dist-in 3.4797 None TPO198 TPO198 XRAY 2.8 0.216 0.287 B 350.0 327.0 3 25 25 0 [[44, 298]] 1.0 3o7l Mus musculus AGC_PRKACA_MOUSE AGC 8.9e-94 319.5 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3FHIA P05132 14 351 351.0 ANP:60400 ATPlike Active DFGin 5.4633 14.263 BLAminus -118.0, -179.45 64.04, 75.7 -86.07, 24.14 267.17, 53.33 -59.82, -32.06 in-in in 8.8874 Saltbr-in 2.7901 HRD-in -94.84, -53.37 68.02, 7.49 in-in-in SNCiii in-in ActLoopNT-in 2.8652 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.67, 136.88 APE9-dihe-na 156.84, -158.52 APE8-dihe-in -126.08, 132.83 APE8-rot-in 296.09 APE67-dihe-in -67.08, -19.88 -42.62, -50.01 APE12-dist-in 8.2333 APE11-dist-in 11.1199 APE10-dist-in 5.402 APE9-dist-in 3.5636 C200A TPO198,SEP339 TPO198,SEP339 XRAY 2.0 0.199 0.226 A 350.0 338.0 0 25 25 0 [[44, 298]] 1.0 3fhi Mus musculus AGC_PRKACA_MOUSE AGC 1e-93 319.3 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC RPS6KA3-1 KS6A3_MOUSE 3G51A P18654 47 346 740.0 ANP:480 ATPlike Inactive DFGin 5.9199 11.0415 None -85.91, -4.29 -148.29, 179.42 -140.68, 33.76 40.5, 80.74 98.88, 16.23 none-none none 999.0 Saltbr-none 999.0 HRD-in -65.38, -43.56 85.71, -58.97 none-out-none SNCnon out-none ActLoopNT-out 10.0751 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 76.27 APE8-rot-in 334.43 APE67-dihe-in -57.95, -24.46 -80.48, -16.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.8 0.216 0.248 A 325.0 280.0 20 28 17 11 [[68, 327], [422, 679]] 2.0 3g51 Mus musculus AGC_RPS6KA3-1_MOUSE AGC 2.6e-97 330.9 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
CAMK CAMK2A KCC2A_MOUSE 7B56B P11798 5 307 478.0 ANP:60401 ATPlike Active DFGin 6.7287 14.2318 BLAminus -127.69, 175.68 61.5, 79.97 -89.44, 23.96 289.95, 77.46 -66.33, -24.14 in-in in 8.9633 Saltbr-in 2.7967 HRD-in -75.83, -42.64 71.61, -6.11 in-in-in SNCiii in-in ActLoopNT-in 2.8909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.35, 145.48 APE9-dihe-na 136.45, -166.63 APE8-dihe-in -115.36, 130.21 APE8-rot-in 297.52 APE67-dihe-in -66.37, -13.84 -48.36, -50.63 APE12-dist-in 10.4062 APE11-dist-in 11.6697 APE10-dist-in 5.8831 APE9-dist-in 3.7986 T305A,T306A None None XRAY 1.45 0.191 0.215 B 317.0 303.0 0 28 28 0 [[13, 271]] 1.0 7b56 Mus musculus CAMK_CAMK2A_MOUSE CAMK 1.7e-96 328.6 1.0 256.0 256.0 155 156 157 159 161 42 60 64 132 134 133 135.0 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK MELK MELK_MOUSE 4BFMA Q61846 2 326 643.0 ANP:61000 ATPlike None DFGin 6.7119 14.5698 BLAminus -130.6, -176.06 61.21, 74.64 -103.71, 23.71 285.06, 77.6 -76.76, -13.34 in-in in 8.8474 Saltbr-in 2.9578 HRD-in -75.69, -53.65 79.25, -5.08 in-in-none SNCiin in-none ActLoopNT-in 2.981 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 98.82 APE9-dihe-na 96.69, 172.23 APE8-dihe-in -57.02, 129.84 APE8-rot-in 295.1 APE67-dihe-in -57.11, -19.89 -56.29, -48.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.4427 APE9-dist-in 3.747 T167E None None XRAY 2.35 0.177 0.208 A 334.0 308.0 17 29 17 12 [[11, 263]] 1.0 4bfm Mus musculus CAMK_MELK_MOUSE CAMK 3.3e-88 301.6 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
OTHER POMK SG196_MOUSE 5GZ9A Q3TUA9 54 337 349.0 ANP:1001,MAN:1004 ATPlike,Allosteric Pseudo DFGin 5.2933 13.0229 ABAminus -119.99, -54.35 -93.01, 108.48 -116.58, 23.4 308.09, 4.31 -55.72, -49.95 none-na none 999.0 Saltbr-na 999.0 HRD-out -81.79, 73.24 -60.09, -38.65 na-in-out SNCaio in-out ActLoopNT-in 3.248 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_iioo APE10-dihe-na -60.33, 128.48 APE9-dihe-na -97.57, 144.89 APE8-dihe-in -131.17, 161.49 APE8-rot-na 301.17 APE67-dihe-out -101.62, -18.24 97.94, -172.65 APE12-dist-in 12.5486 APE11-dist-in 13.7295 APE10-dist-out 17.531 APE9-dist-out 9.7434 N66Q,N164Q None None XRAY 2.4 0.234 0.268 A 305.0 280.0 4 31 29 2 [[73, 337]] 1.0 5gz9 Mus musculus OTHER_POMK_MOUSE POMK 1.2e-147 496.2 1.0 265.0 265.0 225 226 227 229 231 107 121 125 200 202 201 203.0 280 256 251 250 249 248 247 246 245 149 Protein O-mannose kinase
STE STK39 STK39_MOUSE 5DBXA Q9Z1W9 65 365 556.0 ANP:401 ATPlike Inactive DFGin 6.8713 15.5873 None -61.74, 151.25 -53.68, 129.38 -99.47, -2.77 72.69, 109.41 -58.5, -56.73 out-out out 16.0249 Saltbr-out 17.4351 HRD-in -69.21, -49.56 75.54, -19.7 out-out-out SNCooo out-out ActLoopNT-out 5.6736 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -90.7, -9.1 APE9-dihe-na -96.35, 164.45 APE8-dihe-in -91.01, 125.18 APE8-rot-in 324.0 APE67-dihe-in -65.76, -19.67 -49.27, -43.15 APE12-dist-none 999.0 APE11-dist-out 25.0408 APE10-dist-out 28.2167 APE9-dist-out 27.3477 T243D None CAS71,CAS128,CAS249,CAS346 XRAY 2.5 0.208 0.246 A 328.0 288.0 13 33 20 13 [[75, 349]] 1.0 5dbx Mus musculus STE_STK39_MOUSE STE 2.3e-90 308.4 1.0 257.0 257.0 221 222 223 225 227 104 121 125 201 203 202 204.0 267 254 249 248 247 246 245 244 243 151 STE20/SPS1-related proline-alanine-rich protein kinase
STE STK39 STK39_MOUSE 5DBXB Q9Z1W9 65 364 556.0 ANP:401 ATPlike Inactive DFGin 6.3307 15.0679 None -67.52, 160.16 -60.64, 125.44 -102.44, -1.98 62.33, 96.08 -52.97, -52.55 out-out out 14.0364 Saltbr-out 13.266 HRD-in -73.49, -48.67 74.98, -19.73 out-out-out SNCooo out-out ActLoopNT-out 5.6752 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -104.19, 109.41 APE9-dihe-na 87.86, -153.92 APE8-dihe-in -128.52, 139.93 APE8-rot-in 317.58 APE67-dihe-in -74.81, -17.12 -52.01, -48.65 APE12-dist-none 999.0 APE11-dist-out 25.567 APE10-dist-out 25.1599 APE9-dist-out 27.7398 T243D None CAS71,CAS128,CAS249,CAS346 XRAY 2.5 0.208 0.246 B 328.0 286.0 14 33 23 10 [[75, 349]] 1.0 5dbx Mus musculus STE_STK39_MOUSE STE 2.3e-90 308.4 1.0 257.0 257.0 221 222 223 225 227 104 121 125 201 203 202 204.0 267 254 249 248 247 246 245 244 243 151 STE20/SPS1-related proline-alanine-rich protein kinase
TKL RIPK3 RIPK3_MOUSE 4M69A Q9QZL0 12 312 486.0 ANP:60401 ATPlike Inactive DFGin 6.3203 13.4024 BLBplus -137.99, 167.73 62.19, 26.69 -80.85, 141.15 41.42, 94.11 79.17, -4.63 out-out out 16.1877 Saltbr-out 16.6938 HRD-in -64.86, -72.1 85.35, 0.02 out-out-out SNCooo out-out ActLoopNT-out 6.4335 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -38.44, -35.37 APE9-dihe-na -67.82, -39.64 APE8-dihe-out -81.63, -25.9 APE8-rot-out 193.07 APE67-dihe-in -56.22, -29.66 -74.57, -26.5 APE12-dist-out 15.2297 APE11-dist-out 16.6409 APE10-dist-out 19.2359 APE9-dist-out 12.3635 None SEP184,TPO231,SEP232 SEP184,TPO231,SEP232 XRAY 2.497 0.222 0.246 A 313.0 287.0 14 34 20 14 [[20, 290]] 1.0 4m69 Mus musculus TKL_RIPK3_MOUSE TKL 7.1e-60 208.7 3.0 265.0 263.0 160 161 162 164 166 51 61 65 140 142 141 143.0 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TYR EPHB2 EPHB2_MOUSE 1JPAA P54763 594 892 986.0 ANP:60400 ATPlike Inactive DFGin 5.7088 15.4887 None -134.81, -163.21 68.34, 57.99 -95.68, 999.0 294.45, 106.32 999.0, 999.0 in-in in 7.779 Saltbr-in 3.0192 HRD-in -67.2, -47.6 76.65, -18.41 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -14.15 APE8-rot-na 35.93 APE67-dihe-in -72.25, 3.83 -49.21, -49.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y596F,Y602F None None XRAY 1.91 0.231 0.27 A 312.0 273.0 26 33 10 23 [[621, 882]] 1.0 1jpa Mus musculus TYR_EPHB2_MOUSE TYR 5.1e-109 369.5 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR EPHB2 EPHB2_MOUSE 1JPAB P54763 594 891 986.0 ANP:60401 ATPlike Inactive DFGin 5.7317 15.6268 None -133.42, -158.93 64.89, 61.18 -100.9, 999.0 292.25, 96.96 999.0, 999.0 in-in in 7.8146 Saltbr-in 2.6861 HRD-in -67.92, -50.57 78.02, -16.62 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -24.77 APE8-rot-na 326.13 APE67-dihe-in -71.91, 4.89 -51.95, -48.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y596F,Y602F None None XRAY 1.91 0.231 0.27 B 312.0 269.0 29 33 10 23 [[621, 882]] 1.0 1jpa Mus musculus TYR_EPHB2_MOUSE TYR 5.1e-109 369.5 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR LYN LYN_MOUSE 2ZV8A P25911 239 501 512.0 ANP:60001 ATPlike Active DFGin 6.2069 14.1657 BLAminus -127.46, 176.54 66.14, 76.26 -98.89, 34.27 306.37, 82.39 -66.23, -26.52 in-in in 8.1816 Saltbr-in 2.8879 HRD-naN -93.92, -49.32 76.02, -10.27 in-in-in SNCiii in-in ActLoopNT-in 2.9539 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -123.91, 116.52 APE9-dihe-in -60.43, 148.58 APE8-dihe-in -80.52, 92.26 APE8-rot-na 28.17 APE67-dihe-in -68.44, -3.54 -43.41, -52.9 APE12-dist-na 9.6338 APE11-dist-na 5.9229 APE10-dist-na 9.7285 APE9-dist-in 5.0044 None None None XRAY 2.7 0.201 0.245 A 279.0 256.0 7 29 22 7 [[247, 499]] 1.0 2zv8 Mus musculus TYR_LYN_MOUSE TYR 4.1e-95 323.9 1.0 260.0 260.0 384 385 386 388 390 275 290 294 364 366 365 367.0 425 413 408 407 406 405 404 403 402 320 Tyrosine-protein kinase Lyn
OTHER PAN3 PAN3_NEUCR 4CZYB Q7SDP4 234 645 656.0 ANP:61650 ATPlike Pseudo DFGin 8.6364 12.9995 None -108.01, 7.82 -124.9, 18.28 -71.16, 143.54 291.41, 999.0 81.95, -4.35 out-na out 13.9696 Saltbr-na 999.0 HRD-in -64.78, -43.28 69.3, -58.59 na-out-na SNCaoa out-na ActLoopNT-out 7.0417 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -68.73, -37.24 APE9-dihe-na -75.95, -42.57 APE8-dihe-na -71.33, -35.43 APE8-rot-na 302.88 APE67-dihe-na -61.0, -48.02 -101.37, 21.03 APE12-dist-na 1.5444 APE11-dist-na 4.8399 APE10-dist-na 5.8244 APE9-dist-na 11.7693 None None None XRAY 3.4 0.223 0.263 B 429.0 403.0 6 15 15 0 [[258, 516]] 1.0 4czy Neurospora crassa OTHER_PAN3_NEUCR PAN3 3.4e-53 189.3 4.0 264.0 261.0 424 425 426 428 430 302 318 322 405 407 406 408.0 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
OTHER PAN3 PAN3_NEUCR 4CZYD Q7SDP4 234 645 656.0 ANP:61650 ATPlike Pseudo DFGin 8.3891 12.6265 None -108.63, 8.9 -122.37, 20.29 -71.82, 141.42 292.67, 999.0 81.18, -5.38 out-na out 13.9082 Saltbr-na 999.0 HRD-in -65.6, -43.11 68.0, -59.39 na-out-na SNCaoa out-na ActLoopNT-out 6.9602 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -69.97, -39.27 APE9-dihe-na -74.97, -41.75 APE8-dihe-na -69.88, -35.71 APE8-rot-na 304.18 APE67-dihe-na -59.83, -48.03 -102.6, 21.19 APE12-dist-na 1.5346 APE11-dist-na 4.8332 APE10-dist-na 5.6883 APE9-dist-na 12.0116 None None None XRAY 3.4 0.223 0.263 D 429.0 403.0 6 15 15 0 [[258, 516]] 1.0 4czy Neurospora crassa OTHER_PAN3_NEUCR PAN3 3.4e-53 189.3 4.0 264.0 261.0 424 425 426 428 430 302 318 322 405 407 406 408.0 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
STE MAP2K1 MP2K1_RABIT 7JUWC P29678 40 382 393.0 ANP:401 ATPlike Inactive DFGin 5.4761 13.4814 BLBplus -119.08, 163.59 62.65, 35.07 -73.68, 154.5 52.17, 104.28 -73.77, 81.69 out-out out 15.4699 Saltbr-out 15.9777 HRD-in -78.46, -50.39 75.67, -1.62 out-out-out SNCooo out-out ActLoopNT-out 9.0937 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -134.09, 125.81 APE9-dihe-na -89.61, -160.68 APE8-dihe-out -92.22, -18.15 APE8-rot-out 194.93 APE67-dihe-out -134.04, 131.23 -117.23, 164.93 APE12-dist-out 17.3483 APE11-dist-out 16.6141 APE10-dist-out 20.5819 APE9-dist-out 12.6092 None None None XRAY 2.88 0.245 0.286 C 384.0 311.0 32 26 26 0 [[68, 361]] 1.0 7juw Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JURC P29678 41 381 393.0 ANP:401,QOM:402 ATPlike,Type1 Inactive DFGin 6.613 14.002 BLBplus -156.22, 177.66 63.23, 45.15 -109.91, 167.01 49.79, 96.28 -84.59, 94.82 out-out out 15.2731 Saltbr-out 15.8781 HRD-in -66.44, -49.39 76.73, -8.84 out-out-out SNCooo out-out ActLoopNT-out 9.5088 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -118.97, 111.39 APE9-dihe-na -105.66, -145.56 APE8-dihe-out -103.38, -4.62 APE8-rot-out 47.7 APE67-dihe-out -108.36, 139.88 -114.51, 107.19 APE12-dist-out 17.0478 APE11-dist-out 19.9859 APE10-dist-out 22.0123 APE9-dist-out 15.1448 None None None XRAY 2.82 0.237 0.277 C 384.0 304.0 37 26 26 0 [[68, 361]] 1.0 7jur Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JUTC P29678 41 380 393.0 ANP:401,3EW:402 ATPlike,Type3 Inactive DFGin 6.0671 13.9401 BLBplus -133.84, -178.36 52.69, 31.27 -86.2, 157.2 55.82, 93.16 -83.8, 97.49 out-out out 15.809 Saltbr-out 15.0751 HRD-in -69.63, -49.75 78.05, -10.01 out-out-out SNCooo out-out ActLoopNT-out 9.5518 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -106.95, 117.74 APE9-dihe-na -110.82, -149.07 APE8-dihe-out -94.42, -11.28 APE8-rot-out 36.3 APE67-dihe-out -120.05, 132.49 -111.03, 116.45 APE12-dist-out 17.2399 APE11-dist-out 19.8243 APE10-dist-out 21.7513 APE9-dist-out 14.8236 None None None XRAY 3.09 0.259 0.3 C 384.0 303.0 37 26 26 0 [[68, 361]] 1.0 7jut Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JUUC P29678 43 381 393.0 ANP:401,4BM:402 ATPlike,Type3 Inactive DFGin 6.5736 14.0084 BLBplus -143.65, 177.32 57.69, 37.46 -92.33, 152.26 41.94, 94.89 -75.77, 92.54 out-out out 15.833 Saltbr-out 14.7395 HRD-in -70.37, -49.34 74.88, -6.99 out-out-out SNCooo out-out ActLoopNT-out 9.3359 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -102.48, 121.01 APE9-dihe-na -118.18, -151.72 APE8-dihe-out -92.91, -15.39 APE8-rot-out 41.03 APE67-dihe-out -126.24, 128.64 -103.62, 122.66 APE12-dist-out 16.8116 APE11-dist-out 19.5747 APE10-dist-out 21.4997 APE9-dist-out 14.8147 None None None XRAY 3.19 0.242 0.258 C 384.0 302.0 37 26 26 0 [[68, 361]] 1.0 7juu Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JUVC P29678 41 381 393.0 ANP:401,VKG:402 ATPlike,Type3 Inactive DFGin 6.2421 14.0185 BLBplus -157.56, 157.79 64.55, 38.6 -93.84, 164.37 42.83, 100.3 -83.58, 81.75 out-out out 16.0313 Saltbr-out 15.4096 HRD-in -64.23, -51.09 77.84, -3.99 out-out-out SNCooo out-out ActLoopNT-out 9.291 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -121.06, 123.07 APE9-dihe-na -111.51, -147.21 APE8-dihe-out -99.25, -5.79 APE8-rot-out 47.73 APE67-dihe-out -106.23, 137.61 -113.69, 113.69 APE12-dist-out 16.9686 APE11-dist-out 20.03 APE10-dist-out 21.6139 APE9-dist-out 15.1297 None None None XRAY 3.36 0.242 0.255 C 384.0 304.0 37 26 26 0 [[68, 361]] 1.0 7juv Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JUXC P29678 40 381 393.0 ANP:401,QOM:402 ATPlike,Type3 Inactive DFGin 6.4278 14.3556 BLBplus -129.48, -171.66 44.07, 32.82 -84.98, 164.12 41.6, 98.75 -82.14, 71.95 out-out out 17.5863 Saltbr-out 20.1916 HRD-in -72.38, -56.06 82.77, -10.45 out-out-out SNCooo out-out ActLoopNT-out 9.1972 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -105.79, 149.07 APE9-dihe-na -128.12, -140.49 APE8-dihe-out -102.97, -28.75 APE8-rot-out 180.26 APE67-dihe-out -123.35, 132.01 -101.05, 135.7 APE12-dist-out 15.9606 APE11-dist-out 18.6447 APE10-dist-out 21.1274 APE9-dist-out 13.9765 None None None XRAY 3.34 0.265 0.283 C 384.0 308.0 34 26 26 0 [[68, 361]] 1.0 7jux Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JUYC P29678 40 382 393.0 ANP:401,EUI:402 ATPlike,Type3 Inactive DFGin 5.8023 13.9446 BLBplus -119.74, 162.94 62.38, 34.15 -75.02, 153.8 53.17, 104.23 -74.72, 81.57 out-out out 15.6895 Saltbr-out 15.7759 HRD-in -78.99, -50.85 75.95, -2.2 out-out-out SNCooo out-out ActLoopNT-out 8.6396 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -134.38, 125.81 APE9-dihe-na -89.68, -160.4 APE8-dihe-out -91.9, -17.82 APE8-rot-out 194.83 APE67-dihe-out -134.16, 130.72 -117.22, 165.02 APE12-dist-out 17.5274 APE11-dist-out 16.8292 APE10-dist-out 20.535 APE9-dist-out 12.5725 None None None XRAY 3.096 0.248 0.257 C 384.0 311.0 32 26 26 0 [[68, 361]] 1.0 7juy Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JUZC P29678 40 382 393.0 ANP:401,3EW:402 ATPlike,Type3 Inactive DFGin 5.9412 14.2448 BLBplus -127.35, 173.99 64.59, 36.11 -89.55, 153.11 55.39, 95.23 -79.11, 95.72 out-out out 16.8967 Saltbr-out 15.3901 HRD-in -78.66, -56.19 75.89, -1.31 out-out-out SNCooo out-out ActLoopNT-out 8.8285 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -140.68, 119.69 APE9-dihe-na -83.26, -173.5 APE8-dihe-out -76.47, -20.99 APE8-rot-out 195.18 APE67-dihe-out -133.01, 129.38 -114.64, 162.26 APE12-dist-out 17.257 APE11-dist-out 16.6053 APE10-dist-out 20.4548 APE9-dist-out 12.4227 None None None XRAY 3.21 0.255 0.272 C 384.0 308.0 35 26 26 0 [[68, 361]] 1.0 7juz Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JV0C P29678 40 382 393.0 ANP:401,4BM:402 ATPlike,Type3 Inactive DFGin 5.8727 14.2702 BLBplus -118.46, 167.04 65.91, 31.94 -77.55, 158.19 54.28, 101.68 -82.73, 82.06 out-out out 16.4454 Saltbr-out 16.8702 HRD-in -78.95, -48.37 72.45, 0.0 out-out-out SNCooo out-out ActLoopNT-out 8.9767 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -134.69, 127.82 APE9-dihe-na -92.23, -161.01 APE8-dihe-out -91.79, -17.2 APE8-rot-out 194.87 APE67-dihe-out -131.33, 129.9 -118.91, 161.4 APE12-dist-out 17.5672 APE11-dist-out 16.9191 APE10-dist-out 20.7981 APE9-dist-out 12.6788 None None None XRAY 3.63 0.247 0.26 C 384.0 308.0 35 26 26 0 [[68, 361]] 1.0 7jv0 Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JV1C P29678 40 381 393.0 ANP:401,VKG:402 ATPlike,Type3 Inactive DFGin 6.4027 13.987 BLBplus -129.45, -171.63 44.64, 33.58 -84.88, 163.88 41.4, 98.6 -82.69, 72.31 out-out out 17.7833 Saltbr-out 17.8868 HRD-in -72.64, -55.74 83.07, -10.49 out-out-out SNCooo out-out ActLoopNT-out 9.5186 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -106.03, 153.74 APE9-dihe-na -129.76, -140.43 APE8-dihe-out -102.55, -29.44 APE8-rot-out 180.23 APE67-dihe-out -122.99, 132.28 -101.94, 135.93 APE12-dist-out 15.759 APE11-dist-out 19.0444 APE10-dist-out 21.0399 APE9-dist-out 14.1526 None None None XRAY 3.62 0.278 0.303 C 384.0 308.0 34 26 26 0 [[68, 361]] 1.0 7jv1 Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JUSC P29678 41 381 393.0 VKD:501,ANP:502 Type3,ATPlike Inactive DFGin 6.6408 14.136 BLBplus -157.57, 158.09 64.1, 38.39 -94.54, 165.57 43.42, 100.58 -82.33, 83.96 out-out out 16.4432 Saltbr-out 17.0647 HRD-in -64.72, -50.01 79.43, -5.86 out-out-out SNCooo out-out ActLoopNT-out 9.2055 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -121.8, 123.06 APE9-dihe-na -111.39, -149.55 APE8-dihe-out -101.45, -2.19 APE8-rot-out 46.64 APE67-dihe-out -107.18, 138.05 -110.5, 111.25 APE12-dist-out 16.9565 APE11-dist-out 19.7412 APE10-dist-out 21.5845 APE9-dist-out 15.1016 None None None XRAY 2.99 0.249 0.265 C 384.0 304.0 37 26 26 0 [[68, 361]] 1.0 7jus Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
OTHER PINK1 PINK1_PEDHC 8UYHA E0W1I1 115 574 575.0 ANP:601 ATPlike Active DFGin 9.3218 14.8193 BLAminus -130.08, -169.42 57.7, 62.71 -86.71, 26.39 286.61, 80.23 -66.61, -35.48 in-in in 7.9669 Saltbr-in 3.2696 HRD-in -73.02, -43.12 61.9, 7.28 in-in-in SNCiii in-in ActLoopNT-in 2.7639 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na 161.16, -131.74 APE9-dihe-na -112.83, -108.55 APE8-dihe-in -69.42, 145.98 APE8-rot-na 76.98 APE67-dihe-in -73.97, -39.08 -95.26, -9.75 APE12-dist-in 8.0481 APE11-dist-in 10.2621 APE10-dist-in 5.8343 APE9-dist-in 3.5719 None TPO305 TPO305 EM 2.84 999.0 999.0 A 463.0 375.0 49 34 34 0 [[64, 514]] 1.0 8uyh Pediculus humanus OTHER_PINK1_PEDHC PINK1 1e-86 297.1 4.0 367.0 364.0 356 357 358 360 362 193 214 218 331 333 332 334.0 408 390 385 384 383 382 381 380 379 291 Serine/threonine-protein kinase Pink1, mitochondrial
OTHER PINK1 PINK1_PEDHC 8UYHB E0W1I1 121 574 575.0 ANP:601 ATPlike Active DFGin 9.4492 14.8706 BLAminus -129.89, -169.12 59.53, 64.83 -87.85, 20.05 283.99, 82.98 -70.23, -23.56 in-in in 7.8465 Saltbr-in 2.3873 HRD-in -70.23, -41.92 63.21, 0.58 in-in-in SNCiii in-in ActLoopNT-in 2.9317 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na 144.56, -157.47 APE9-dihe-na -105.64, -99.0 APE8-dihe-in -70.54, 139.11 APE8-rot-na 52.17 APE67-dihe-in -71.03, -46.42 -78.22, -15.68 APE12-dist-in 7.74 APE11-dist-in 10.3854 APE10-dist-in 6.127 APE9-dist-in 3.7808 None TPO305 TPO305 EM 2.84 999.0 999.0 B 463.0 370.0 50 34 34 0 [[64, 514]] 1.0 8uyh Pediculus humanus OTHER_PINK1_PEDHC PINK1 1e-86 297.1 4.0 367.0 364.0 356 357 358 360 362 193 214 218 331 333 332 334.0 408 390 385 384 383 382 381 380 379 291 Serine/threonine-protein kinase Pink1, mitochondrial
CAMK CDPK1 CDPK1_PLABA 3Q5IA A0A509AHB6 38 518 523.0 ANP:61634 ATPlike Active DFGin 6.7672 14.4658 BLAminus -128.23, -176.48 60.5, 79.46 -95.96, 19.56 285.65, 75.94 -57.69, -30.19 in-in in 9.2369 Saltbr-in 3.1236 HRD-in -79.9, -50.9 74.57, -2.92 in-in-in SNCiii in-in ActLoopNT-in 2.9879 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.44, 148.94 APE9-dihe-na 143.23, -165.03 APE8-dihe-in -126.86, 133.51 APE8-rot-in 304.61 APE67-dihe-in -56.9, -32.89 -45.51, -52.84 APE12-dist-in 8.5894 APE11-dist-in 11.4649 APE10-dist-in 5.6669 APE9-dist-in 3.6336 None None None XRAY 2.1 0.197 0.25 A 504.0 461.0 18 27 27 0 [[57, 324]] 1.0 3q5i Plasmodium berghei CAMK_CDPK1_PLABA CAMK 4e-85 291.5 4.0 256.0 253.0 210 211 212 214 216 86 115 119 187 189 188 190.0 248 237 232 231 230 229 228 227 226 145 Calcium-dependent protein kinase 1
CMGC MAPK Q7KQK7_PLAF7 3NIEA Q7KQK7 95 499 508.0 ANP:60430 ATPlike Inactive DFGin 6.659 15.7756 BLAminus -144.93, -172.32 65.91, 51.77 -86.61, 14.68 283.07, 77.79 -60.63, -18.53 in-in in 8.8674 Saltbr-in 2.5027 HRD-in -68.06, -47.27 80.58, -8.2 in-in-out SNCiio in-out ActLoopNT-in 2.8564 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -70.3, 124.83 APE9-dihe-na -125.0, 112.94 APE8-dihe-in -93.96, 116.45 APE8-rot-in 298.12 APE67-dihe-in -72.32, -16.48 -104.15, 8.37 APE12-dist-out 16.933 APE11-dist-in 12.6333 APE10-dist-out 15.2444 APE9-dist-out 11.2001 None None None XRAY 2.3 0.225 0.268 A 429.0 364.0 41 53 22 31 [[106, 446]] 1.0 3nie Plasmodium falciparum CMGC_MAPK_PLAF7 CMGC 8.1e-36 228.5 1.0 161.0 305.0 249 250 251 253 255 135 153 157 229 231 230 232.0 315 302 297 296 295 294 293 292 291 188 Mitogen-activated protein kinase
CMGC MAPK Q7KQK7_PLAF7 3NIEB Q7KQK7 95 505 508.0 ANP:60430 ATPlike Inactive DFGin 6.2209 15.3557 BLAminus -134.35, -174.02 73.7, 49.83 -83.77, 18.2 290.52, 87.11 -64.56, -24.17 in-in in 8.7675 Saltbr-in 2.6099 HRD-in -70.6, -44.59 78.38, -12.33 in-in-out SNCiio in-out ActLoopNT-in 2.654 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -62.89, 130.52 APE9-dihe-na -133.69, 126.34 APE8-dihe-in -95.72, 114.26 APE8-rot-in 300.21 APE67-dihe-in -71.21, -11.01 -104.83, 7.14 APE12-dist-out 17.1903 APE11-dist-in 12.7805 APE10-dist-out 15.2581 APE9-dist-out 11.2183 None None None XRAY 2.3 0.225 0.268 B 429.0 367.0 44 53 21 32 [[106, 446]] 1.0 3nie Plasmodium falciparum CMGC_MAPK_PLAF7 CMGC 8.1e-36 228.5 1.0 161.0 305.0 249 250 251 253 255 135 153 157 229 231 230 232.0 315 302 297 296 295 294 293 292 291 188 Mitogen-activated protein kinase
CMGC PSTK1 Q8IL19_PLAF7 3LLTA Q8IL19 535 875 881.0 ANP:877 ATPlike Active DFGin 7.1427 15.2163 BLAminus -123.92, -179.42 67.73, 65.46 -96.96, 21.34 280.85, 86.26 -60.95, -43.39 in-in in 9.0128 Saltbr-in 2.6211 HRD-in -67.76, -41.54 71.0, -10.38 in-in-in SNCiii in-in ActLoopNT-in 2.8536 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.91, 173.39 APE9-dihe-na 75.57, 154.71 APE8-dihe-in -70.15, 136.15 APE8-rot-in 300.24 APE67-dihe-in -71.32, -17.13 -39.04, -49.24 APE12-dist-in 13.2051 APE11-dist-in 11.3898 APE10-dist-in 7.5138 APE9-dist-in 2.9414 None None None XRAY 2.5 0.225 0.267 A 360.0 341.0 0 25 25 0 [[552, 874]] 1.0 3llt Plasmodium falciparum CMGC_PSTK1_PLAF7 CMGC 8.3e-71 244.6 2.0 301.0 300.0 719 720 721 723 725 581 596 600 674 676 675 677.0 756 744 739 738 737 736 735 734 733 631 Protein serine/threonine kinase-1
OTHER PK7 O96214_PLAFA 2PMLX O96214 1 316 320.0 ANP:60381 ATPlike Inactive DFGin 7.27 13.6658 BLAminus -145.98, -179.86 51.66, 93.56 -100.75, 34.63 303.23, 91.32 -71.84, -18.04 out-out out 10.1568 Saltbr-out 3.6908 HRD-in -69.85, -44.18 75.61, 1.42 out-in-in SNCoii in-in ActLoopNT-in 2.9421 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -171.9, 141.96 APE9-dihe-na 131.5, -150.95 APE8-dihe-in -107.69, 124.02 APE8-rot-in 304.33 APE67-dihe-in -76.82, -4.32 -47.17, -48.3 APE12-dist-in 11.2869 APE11-dist-in 11.8028 APE10-dist-in 6.3729 APE9-dist-in 3.6802 None None None XRAY 2.6 0.261 0.327 X 348.0 308.0 8 26 26 0 [[28, 319]] 1.0 2pml Plasmodium falciparum OTHER_PK7_PLAFA CAMK 9.9e-37 136.1 1.0 256.0 256.0 189 190 191 193 195 55 88 92 169 171 170 172.0 229 215 210 209 208 207 206 205 204 118 mitogen-activated protein kinase kinase
AGC PKG KGP_PLAVS 5DZCA A5K0N4 1 843 846.0 ANP:61001 ATPlike Inactive DFGin 6.296 14.6954 BLAminus -123.96, 179.25 60.5, 83.72 -97.75, 30.63 287.02, 82.05 -66.77, -34.57 out-out out 10.7499 Saltbr-out 4.7307 HRD-in -75.23, -49.58 78.17, -9.81 out-in-in SNCoii in-in ActLoopNT-in 2.9921 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.27, 147.09 APE9-dihe-na 122.94, -168.21 APE8-dihe-in -102.7, 120.96 APE8-rot-in 294.87 APE67-dihe-in -65.78, -22.03 -47.03, -45.8 APE12-dist-in 9.4444 APE11-dist-in 11.26 APE10-dist-in 5.3904 APE9-dist-in 3.6504 None None None XRAY 2.3 0.223 0.255 A 847.0 815.0 0 25 25 0 [[534, 791]] 1.0 5dzc Plasmodium vivax AGC_PKG_PLAVS AGC 1.3e-75 260.5 3.0 260.0 258.0 674 675 676 678 680 563 582 586 654 656 655 657.0 711 699 694 693 692 691 690 689 688 612 cGMP-dependent protein kinase
AGC PRKCB KPCB_RAT 3PFQA P68403 101 668 671.0 ANP:60800 ATPlike Inactive DFGin 6.062 13.3175 BLAminus -127.91, -175.53 60.89, 88.17 -109.45, 18.93 297.91, 72.76 -66.81, 8.41 in-out in 9.3193 Saltbr-out 4.5108 HRD-out -53.59, -66.06 65.15, 50.69 out-in-in SNCoii in-in ActLoopNT-in 3.087 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.97, -178.34 APE9-dihe-na 109.42, -153.48 APE8-dihe-in -112.52, 141.29 APE8-rot-in 328.3 APE67-dihe-in -90.42, -60.35 -50.4, -26.29 APE12-dist-in 8.8919 APE11-dist-in 11.9645 APE10-dist-in 6.3533 APE9-dist-in 4.0339 C71S,C217S,R622S TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 4.0 0.244 0.244 A 674.0 521.0 0 28 28 0 [[342, 600]] 1.0 3pfq Rattus norvegicus AGC_PRKCB_RAT AGC 1.5e-97 332.1 1.0 260.0 260.0 483 484 485 487 489 371 390 394 463 465 464 466.0 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
CMGC MAPK1 MK01_RAT 4S33A P63086 4 355 358.0 ANP:401 ATPlike Inactive DFGin 6.7431 16.086 BLAminus -130.86, 178.79 71.13, 76.62 -98.92, 24.03 286.96, 71.68 -62.72, -21.16 in-in in 9.6873 Saltbr-in 2.6802 HRD-in -72.9, -49.96 78.15, -0.96 in-in-out SNCiio in-out ActLoopNT-in 2.8648 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -104.41, -43.84 APE9-dihe-na -64.59, 164.35 APE8-dihe-in -56.21, 123.2 APE8-rot-in 315.9 APE67-dihe-in -61.37, -21.31 -48.55, -49.93 APE12-dist-out 14.7318 APE11-dist-in 11.3056 APE10-dist-in 7.3108 APE9-dist-in 4.4832 R65S None None XRAY 1.48 0.199 0.239 A 358.0 347.0 0 31 31 0 [[23, 311]] 1.0 4s33 Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.5e-85 293.0 1.0 301.0 301.0 164 165 166 168 170 52 69 73 144 146 145 147.0 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 4S32A P63086 4 354 358.0 ANP:401 ATPlike Inactive DFGin 6.6461 16.3353 BLAminus -133.92, 176.75 65.37, 79.23 -97.7, 23.57 287.97, 74.34 -66.64, -19.31 in-out in 9.8686 Saltbr-out 3.654 HRD-in -75.76, -45.6 71.68, 4.61 out-in-out SNCoio in-out ActLoopNT-in 2.8278 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -98.88, -32.08 APE9-dihe-na -65.5, 159.94 APE8-dihe-in -53.88, 129.7 APE8-rot-in 310.08 APE67-dihe-in -61.98, -20.6 -58.72, -45.65 APE12-dist-out 14.5455 APE11-dist-in 11.219 APE10-dist-in 7.4905 APE9-dist-in 4.4333 None None None XRAY 1.34 0.199 0.231 A 358.0 346.0 0 31 31 0 [[23, 311]] 1.0 4s32 Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.3e-85 293.2 1.0 301.0 301.0 164 165 166 168 170 52 69 73 144 146 145 147.0 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 7UGBA P63086 9 354 358.0 ANP:60401 ATPlike Inactive DFGin 6.8438 15.6136 BLAminus -132.85, -175.34 66.19, 68.8 -95.15, 22.62 283.13, 71.04 -65.04, -17.4 in-in in 9.2984 Saltbr-in 3.0947 HRD-in -74.44, -45.95 75.99, -7.39 in-in-out SNCiio in-out ActLoopNT-in 2.7599 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -141.06, 152.87 APE9-dihe-na -67.4, -32.8 APE8-dihe-in -151.29, 138.48 APE8-rot-out 186.29 APE67-dihe-in -67.11, -12.06 -109.33, 7.55 APE12-dist-in 8.5189 APE11-dist-in 12.1904 APE10-dist-out 9.145 APE9-dist-out 11.3673 None None None XRAY 1.9 0.181 0.228 A 380.0 333.0 9 31 22 9 [[23, 311]] 1.0 7ugb Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.6e-85 292.9 1.0 301.0 301.0 164 165 166 168 170 52 69 73 144 146 145 147.0 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 4S34A P63086 4 354 358.0 ANP:402 ATPlike Inactive DFGin 6.9305 15.9209 BLAminus -141.95, 172.44 70.56, 81.84 -99.71, 28.41 294.26, 76.1 -60.19, -38.53 in-out in 9.8624 Saltbr-out 3.6484 HRD-in -79.44, -51.86 83.9, -4.35 out-in-out SNCoio in-out ActLoopNT-in 2.8808 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -91.12, -42.94 APE9-dihe-na -58.97, 168.13 APE8-dihe-in -69.02, 123.37 APE8-rot-in 313.04 APE67-dihe-in -67.86, -24.53 -49.65, -45.75 APE12-dist-out 14.8428 APE11-dist-in 11.3273 APE10-dist-in 7.2767 APE9-dist-in 4.4811 I84A None None XRAY 2.5 0.182 0.255 A 358.0 343.0 0 31 31 0 [[23, 311]] 1.0 4s34 Rattus norvegicus CMGC_MAPK1_RAT CMGC 2.9e-85 292.1 1.0 301.0 301.0 164 165 166 168 170 52 69 73 144 146 145 147.0 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 8RQVA P63086 4 354 358.0 ANP:501 ATPlike Inactive DFGin 6.9036 16.0694 BLAminus -129.6, -175.7 63.15, 70.39 -89.62, 28.98 289.85, 76.4 -67.34, -38.13 in-out in 9.7114 Saltbr-out 4.2746 HRD-in -67.81, -55.04 72.76, 2.89 out-in-out SNCoio in-out ActLoopNT-in 2.7655 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oiii APE10-dihe-na -100.88, -30.73 APE9-dihe-na -77.54, 159.87 APE8-dihe-in -50.38, 124.93 APE8-rot-none 999.0 APE67-dihe-in -63.77, -19.96 -54.06, -49.39 APE12-dist-out 14.154 APE11-dist-in 10.7528 APE10-dist-in 7.0254 APE9-dist-in 4.3496 T188A None None XRAY 2.19 0.22 0.268 A 365.0 346.0 0 31 31 0 [[23, 311]] 1.0 8rqv Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.1e-84 290.1 1.0 301.0 301.0 164 165 166 168 170 52 69 73 144 146 145 147.0 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 8RQXA P63086 4 353 358.0 ANP:501 ATPlike Inactive DFGin 6.7525 15.7711 BLAminus -131.54, -179.98 70.52, 77.44 -96.49, 23.47 286.75, 76.4 -63.49, -27.29 in-out in 9.2826 Saltbr-out 4.0303 HRD-in -71.44, -55.38 74.63, 0.71 out-in-out SNCoio in-out ActLoopNT-in 2.8623 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oiii APE10-dihe-na -102.41, -41.91 APE9-dihe-na -63.48, 155.78 APE8-dihe-in -53.17, 123.33 APE8-rot-na 196.55 APE67-dihe-in -71.02, -16.45 -50.75, -40.77 APE12-dist-out 14.2124 APE11-dist-in 10.7678 APE10-dist-in 6.9866 APE9-dist-in 4.4522 R65S,T188D None None XRAY 1.7 0.199 0.231 A 365.0 344.0 0 31 31 0 [[23, 311]] 1.0 8rqx Rattus norvegicus CMGC_MAPK1_RAT CMGC 3.4e-84 288.6 1.0 301.0 301.0 164 165 166 168 170 52 69 73 144 146 145 147.0 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 8RQWA P63086 4 354 358.0 ANP:501 ATPlike Inactive DFGin 6.8494 16.0159 BLAminus -129.63, 178.83 67.86, 79.37 -97.6, 20.5 285.29, 78.65 -60.41, -30.78 in-out in 9.7711 Saltbr-out 4.0654 HRD-in -69.59, -52.69 70.29, 6.23 out-in-out SNCoio in-out ActLoopNT-in 2.8367 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oiii APE10-dihe-na -111.03, -43.37 APE9-dihe-na -66.74, 156.04 APE8-dihe-in -59.11, 129.69 APE8-rot-na 165.64 APE67-dihe-in -63.23, -21.3 -54.35, -46.88 APE12-dist-out 14.6367 APE11-dist-in 10.9228 APE10-dist-in 6.9125 APE9-dist-in 4.2589 T188E None None XRAY 1.8 0.198 0.231 A 365.0 344.0 0 31 31 0 [[23, 311]] 1.0 8rqw Rattus norvegicus CMGC_MAPK1_RAT CMGC 3e-84 288.8 1.0 301.0 301.0 164 165 166 168 170 52 69 73 144 146 145 147.0 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
OTHER WNK1 WNK1_RAT 5W7TA Q9JIH7 210 482 2126.0 ANP:60501 ATPlike Inactive DFGin 6.4172 15.9348 BLBtrans -104.69, 171.72 66.72, 19.42 -58.26, 129.69 184.83, 52.8 82.8, 3.34 out-na out 14.5394 Saltbr-na 999.0 HRD-in -71.27, -50.06 75.36, -9.98 na-out-out SNCaoo out-out ActLoopNT-out 8.5837 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -87.54, -6.4 APE9-dihe-na 140.44, -174.25 APE8-dihe-in -100.52, 116.85 APE8-rot-in 301.69 APE67-dihe-in -56.05, -31.73 -45.94, -43.4 APE12-dist-out 14.8779 APE11-dist-in 11.5748 APE10-dist-out 12.3081 APE9-dist-in 5.4212 None SEP382 SEP382 XRAY 2.01 0.175 0.227 A 277.0 273.0 0 26 26 0 [[220, 479]] 1.0 5w7t Rattus norvegicus OTHER_WNK1_RAT WNK 1.7e-180 603.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_RAT 5W7TB Q9JIH7 210 482 2126.0 ANP:60501 ATPlike Inactive DFGin 6.3857 15.245 BLBtrans -103.97, 173.91 64.08, 22.88 -61.0, 131.49 184.03, 62.56 90.07, -15.7 out-na out 14.1288 Saltbr-na 999.0 HRD-in -70.75, -51.57 74.83, -5.85 na-out-out SNCaoo out-out ActLoopNT-out 7.222 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -112.88, 5.47 APE9-dihe-na -140.59, -178.52 APE8-dihe-in -108.13, 115.32 APE8-rot-in 305.01 APE67-dihe-in -55.56, -28.14 -49.44, -36.46 APE12-dist-out 14.7107 APE11-dist-in 12.593 APE10-dist-in 7.8096 APE9-dist-in 4.793 None SEP382 SEP382 XRAY 2.01 0.175 0.227 B 277.0 273.0 0 26 26 0 [[220, 479]] 1.0 5w7t Rattus norvegicus OTHER_WNK1_RAT WNK 1.7e-180 603.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
AGC CBK1 CBK1_YEAST 4LQSA P53894 294 749 756.0 ANP:801 ATPlike Inactive None 999.0 16.2025 None 53.14, -148.73 -160.92, 157.71 -53.16, -18.83 35.56, 134.57 105.29, -25.04 none-none none 999.0 Saltbr-none 999.0 HRD-in -66.84, -59.33 53.37, 19.81 none-out-out SNCnoo out-out ActLoopNT-out 11.5265 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na 51.76, -143.69 APE9-dihe-na -76.97, 123.71 APE8-dihe-in -85.35, 159.33 APE8-rot-out 194.03 APE67-dihe-out -98.15, -1.82 -67.37, 76.79 APE12-dist-out 18.6277 APE11-dist-out 18.6511 APE10-dist-out 15.2408 APE9-dist-out 9.9075 D475A None None XRAY 3.3 0.272 0.307 A 508.0 372.0 59 89 45 44 [[352, 672]] 1.0 4lqs Saccharomyces cerevisiae AGC_CBK1_YEAST AGC 8.9e-95 322.8 1.0 260.0 260.0 492 493 494 496 498 381 400 404 472 474 473 475.0 593 581 576 575 574 573 572 571 570 430 Serine/threonine-protein kinase CBK1
AGC CBK1 CBK1_YEAST 5NCLA P53894 266 756 756.0 ANP:801 ATPlike Inactive None 999.0 14.7679 None -124.95, -0.24 -167.04, -169.57 -142.87, 6.12 315.3, 73.05 87.79, 14.17 none-none none 999.0 Saltbr-none 999.0 HRD-in -82.26, -37.95 50.09, 24.61 none-out-out SNCnoo out-out ActLoopNT-out 10.0838 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -121.55, -26.93 APE9-dihe-na 94.26, 55.75 APE8-dihe-in -40.67, 138.08 APE8-rot-out 180.68 APE67-dihe-out -56.77, 157.77 -73.6, -6.03 APE12-dist-out 20.6313 APE11-dist-out 16.5018 APE10-dist-out 17.631 APE9-dist-out 9.2099 D475A None None XRAY 3.15 0.237 0.298 A 508.0 418.0 51 89 53 36 [[352, 672]] 1.0 5ncl Saccharomyces cerevisiae AGC_CBK1_YEAST AGC 8.9e-95 322.8 1.0 260.0 260.0 492 493 494 496 498 381 400 404 472 474 473 475.0 593 581 576 575 574 573 572 571 570 430 Serine/threonine-protein kinase CBK1
AGC CBK1 CBK1_YEAST 4LQPA P53894 282 749 756.0 ANP:801 ATPlike Inactive None 11.3491 17.1416 None 51.11, -136.69 -160.15, 166.75 -53.4, -31.02 62.24, 131.47 101.1, -24.98 none-none none 999.0 Saltbr-none 999.0 HRD-in -48.74, -51.29 56.68, 17.66 none-out-out SNCnoo out-out ActLoopNT-out 12.1073 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na 57.38, -156.31 APE9-dihe-na -77.68, 150.18 APE8-dihe-in -91.6, 155.34 APE8-rot-out 192.52 APE67-dihe-out -54.18, -52.1 -73.01, 58.69 APE12-dist-out 19.6278 APE11-dist-out 18.0811 APE10-dist-out 14.8874 APE9-dist-out 10.6047 D475A,T743E None None XRAY 4.5 0.289 0.31 A 508.0 383.0 61 89 40 49 [[352, 672]] 1.0 4lqp Saccharomyces cerevisiae AGC_CBK1_YEAST AGC 8.9e-95 322.8 1.0 260.0 260.0 492 493 494 496 498 381 400 404 472 474 473 475.0 593 581 576 575 574 573 572 571 570 430 Serine/threonine-protein kinase CBK1
AGC CBK1 CBK1_YEAST 4LQQA P53894 282 749 756.0 ANP:801 ATPlike Inactive None 999.0 15.547 None 58.85, -148.63 -164.28, 166.54 -77.58, -28.26 39.76, 84.0 103.41, -23.9 none-none none 999.0 Saltbr-none 999.0 HRD-in -81.04, -47.82 56.38, 16.19 none-out-out SNCnoo out-out ActLoopNT-out 12.3427 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na 56.18, -157.99 APE9-dihe-na -70.4, 122.44 APE8-dihe-in -57.31, 154.98 APE8-rot-out 175.08 APE67-dihe-out -48.49, -76.95 -95.03, 72.04 APE12-dist-out 20.096 APE11-dist-out 18.5667 APE10-dist-out 14.8879 APE9-dist-out 10.3467 D475A,T743E None None XRAY 3.6 0.262 0.319 A 508.0 388.0 55 89 49 40 [[352, 672]] 1.0 4lqq Saccharomyces cerevisiae AGC_CBK1_YEAST AGC 8.9e-95 322.8 1.0 260.0 260.0 492 493 494 496 498 381 400 404 472 474 473 475.0 593 581 576 575 574 573 572 571 570 430 Serine/threonine-protein kinase CBK1
CAMK RAD53 RAD53_YEAST 4PDSA P22216 191 490 821.0 ANP:601 ATPlike None DFGin 6.8268 15.321 BLAminus -118.08, -171.61 59.64, 71.79 -99.48, 20.29 283.31, 64.09 -58.2, -44.36 in-none in 9.0663 Saltbr-none 999.0 HRD-in -71.09, -47.1 62.14, 17.47 none-in-none SNCnin in-none ActLoopNT-in 3.117 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -34.5 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 A225S,D339A None None XRAY 2.9 0.229 0.263 A 347.0 249.0 48 27 13 14 [[198, 466]] 1.0 4pds Saccharomyces cerevisiae CAMK_RAD53_YEAST CAMK 1e-76 264.0 3.0 256.0 254.0 338 339 340 342 344 227 244 248 316 318 317 319.0 390 365 360 359 358 357 356 355 354 274 Serine/threonine-protein kinase RAD53
CAMK RAD53 RAD53_YEAST 4PDSB P22216 191 494 821.0 ANP:601 ATPlike Inactive DFGin 6.7183 15.148 BLAminus -117.97, -170.55 58.98, 70.83 -99.5, 20.74 286.63, 66.01 -58.38, -47.1 in-none in 9.1835 Saltbr-none 999.0 HRD-in -70.11, -46.34 63.04, 16.89 none-in-out SNCnio in-out ActLoopNT-in 2.9807 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 171.9 APE8-rot-out 171.12 APE67-dihe-in -69.32, -29.11 -73.88, 11.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 A225S,D339A None None XRAY 2.9 0.229 0.263 B 347.0 248.0 52 27 15 12 [[198, 466]] 1.0 4pds Saccharomyces cerevisiae CAMK_RAD53_YEAST CAMK 1e-76 264.0 3.0 256.0 254.0 338 339 340 342 344 227 244 248 316 318 317 319.0 390 365 360 359 358 357 356 355 354 274 Serine/threonine-protein kinase RAD53
CAMK RAD53 RAD53_YEAST 5XZVB P22216 32 466 821.0 ANP:60501 ATPlike Inactive DFGin 7.5918 14.0173 BLBminus -134.96, 173.3 66.26, 62.64 -75.82, 145.77 303.09, 74.83 -59.73, 168.49 out-out out 13.6625 Saltbr-out 10.4743 HRD-in -60.41, -45.87 73.76, -6.4 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -100.72, 24.79 APE9-dihe-na -115.73, -142.38 APE8-dihe-in -94.48, 113.04 APE8-rot-in 308.94 APE67-dihe-in -48.8, -28.87 -80.72, -18.69 APE12-dist-in 12.6231 APE11-dist-out 16.6318 APE10-dist-out 16.163 APE9-dist-out 10.3293 None None None XRAY 3.1 0.273 0.289 B 471.0 370.0 29 27 16 11 [[198, 466]] 1.0 5xzv Saccharomyces cerevisiae CAMK_RAD53_YEAST CAMK 1.6e-78 269.9 3.0 256.0 254.0 338 339 340 342 344 227 244 248 316 318 317 319.0 390 365 360 359 358 357 356 355 354 274 Serine/threonine-protein kinase RAD53
CAMK RAD53 RAD53_YEAST 5XZVA P22216 16 465 821.0 ANP:60501 ATPlike Inactive DFGin 7.0643 15.2612 None -121.2, -53.4 -91.08, 125.25 -116.1, 93.37 279.98, 81.22 -112.86, 58.45 in-out in 9.8831 Saltbr-out 4.1817 HRD-out -106.71, 124.14 -85.03, 170.27 out-out-none SNCoon out-none ActLoopNT-out 5.5013 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -63.22, -40.45 999.0, 55.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.1 0.273 0.289 A 471.0 375.0 42 27 13 14 [[198, 466]] 1.0 5xzv Saccharomyces cerevisiae CAMK_RAD53_YEAST CAMK 1.6e-78 269.9 3.0 256.0 254.0 338 339 340 342 344 227 244 248 316 318 317 319.0 390 365 360 359 358 357 356 355 354 274 Serine/threonine-protein kinase RAD53
CMGC CKA1 CSK21_YEAST 4JQEA P15790 3 371 372.0 ANP:401 ATPlike Inactive None 24.2439 16.419 None -115.27, -174.34 56.63, 76.24 -90.39, 14.09 294.74, 85.98 -69.15, -20.82 out-na out 38.3713 Saltbr-na 999.0 HRD-in -70.11, -50.73 74.01, 10.07 na-in-in SNCaii in-in ActLoopNT-in 2.8729 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.74, -177.14 APE9-dihe-na 56.62, -167.2 APE8-dihe-in -120.8, 142.4 APE8-rot-in 319.02 APE67-dihe-in -66.52, -14.17 -32.33, -59.31 APE12-dist-in 12.3841 APE11-dist-in 10.3767 APE10-dist-in 6.0147 APE9-dist-in 3.0334 None None None XRAY 1.77 0.206 0.246 A 374.0 369.0 0 27 27 0 [[100, 363]] 1.0 4jqe Saccharomyces cerevisiae CMGC_CKA1_YEAST CMGC 0.0001 199.7 1.0 55.0 321.0 213 214 215 217 219 69 114 118 192 194 193 195.0 253 240 235 234 233 232 231 230 229 153 Casein kinase II subunit alpha
CMGC SKY1 SKY1_YEAST 1Q99A Q03656 143 737 742.0 ANP:60901 ATPlike Active DFGin 5.8628 12.8174 BLAminus -114.29, -177.44 55.8, 69.3 -86.87, 21.69 289.5, 16.74 -63.01, -13.14 in-in in 9.0097 Saltbr-in 3.3929 HRD-in -74.14, -46.77 73.71, -6.86 in-in-in SNCiii in-in ActLoopNT-in 2.9826 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.75, 166.8 APE9-dihe-na 68.75, 148.0 APE8-dihe-in -82.45, 139.06 APE8-rot-in 296.77 APE67-dihe-in -63.19, -13.43 -18.75, -76.87 APE12-dist-in 12.6355 APE11-dist-in 10.4413 APE10-dist-in 7.6775 APE9-dist-in 2.9962 None None None XRAY 2.11 0.22 0.26 A 373.0 354.0 9 25 25 0 [[158, 706]] 1.0 1q99 Saccharomyces cerevisiae CMGC_SKY1_YEAST CMGC 8.8e-100 339.7 1.0 301.0 301.0 549 550 551 553 555 187 202 206 291 293 292 294.0 586 574 569 568 567 566 565 564 563 247 Serine/threonine-protein kinase SKY1
CMGC SKY1 SKY1_YEAST 1Q99B Q03656 142 737 742.0 ANP:60902 ATPlike Active DFGin 6.0067 13.0756 BLAminus -119.51, 178.42 55.8, 73.86 -88.54, 22.76 281.2, 12.04 -67.31, -20.83 in-in in 8.9906 Saltbr-in 3.4133 HRD-in -77.35, -48.77 76.96, -6.7 in-in-in SNCiii in-in ActLoopNT-in 3.0544 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.48, 168.06 APE9-dihe-na 68.34, 160.67 APE8-dihe-in -99.08, 126.68 APE8-rot-in 289.43 APE67-dihe-in -64.6, -22.58 -5.08, -74.37 APE12-dist-in 12.5561 APE11-dist-in 10.3206 APE10-dist-in 7.7884 APE9-dist-in 3.1584 None None None XRAY 2.11 0.22 0.26 B 373.0 364.0 0 25 25 0 [[158, 706]] 1.0 1q99 Saccharomyces cerevisiae CMGC_SKY1_YEAST CMGC 8.8e-100 339.7 1.0 301.0 301.0 549 550 551 553 555 187 202 206 291 293 292 294.0 586 574 569 568 567 566 565 564 563 247 Serine/threonine-protein kinase SKY1
OTHER BUD32 BUD32_YEAST 4WW5A P53323 5 257 261.0 ANP:301 Type1.5_Front Active DFGin 6.7539 15.3715 BLAminus -131.59, 172.16 63.96, 73.04 -100.08, 21.32 284.27, 93.18 -51.84, -32.53 in-in in 7.6578 Saltbr-in 2.7833 HRD-in -80.73, -50.01 98.03, -11.27 in-in-na SNCiia in-na ActLoopNT-in 2.8804 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -64.97, -44.17 APE9-dihe-na -62.31, -41.0 APE8-dihe-na -66.43, -40.1 APE8-rot-na 172.1 APE67-dihe-na -63.36, -39.55 -55.34, -50.01 APE12-dist-na 15.7306 APE11-dist-na 11.1452 APE10-dist-na 14.7068 APE9-dist-na 11.7134 None None None XRAY 1.997 0.185 0.222 A 261.0 236.0 21 23 23 0 [[17, 261]] 1.0 4ww5 Saccharomyces cerevisiae OTHER_BUD32_YEAST TP53RK 5e-44 156.6 8.0 224.0 217.0 181 182 183 185 187 52 76 80 158 160 159 161.0 198 204 199 198 197 196 195 194 193 107 EKC/KEOPS complex subunit BUD32
OTHER GCN2-2 GCN2_YEAST 1ZY5A P15442 594 996 1659.0 ANP:60303 ATPlike Inactive DFGin 6.4358 13.9477 BLBminus -143.1, -168.47 53.69, 51.66 -54.84, 142.33 286.09, 71.25 -76.51, 124.09 out-out out 12.6608 Saltbr-out 11.0566 HRD-in -67.81, -47.78 76.36, -17.83 out-out-none SNCoon out-none ActLoopNT-out 8.5019 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -71.49, -10.61 999.0, -40.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 R794G None None XRAY 2.0 0.235 0.279 A 303.0 269.0 31 42 17 25 [[292, 527], [599, 981]] 2.0 1zy5 Saccharomyces cerevisiae OTHER_GCN2-2_YEAST STE 3.9e-47 167.3 1.0 254.0 254.0 852 853 854 856 858 628 643 647 832 834 833 835.0 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
OTHER GCN2-2 GCN2_YEAST 1ZY5B P15442 594 983 1659.0 ANP:60304 ATPlike Inactive DFGin 6.6025 13.914 BLBminus -140.22, -166.87 36.36, 56.71 -49.57, 149.56 284.28, 69.17 -88.92, 120.77 out-out out 12.8249 Saltbr-out 9.7993 HRD-in -69.22, -51.57 73.48, -3.27 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -57.67 APE8-dihe-out -69.97, -47.08 APE8-rot-out 170.45 APE67-dihe-in -61.67, -26.23 -38.97, -39.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.7538 R794G None None XRAY 2.0 0.235 0.279 B 303.0 247.0 40 42 13 29 [[292, 527], [599, 981]] 2.0 1zy5 Saccharomyces cerevisiae OTHER_GCN2-2_YEAST STE 3.9e-47 167.3 1.0 254.0 254.0 852 853 854 856 858 628 643 647 832 834 833 835.0 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
AGC PRKACA KAPCA_PIG 1CDKA P36887 9 351 351.0 ANP:60400 ATPlike Active DFGin 5.8431 14.3299 BLAminus -113.76, -166.2 47.38, 80.03 -85.76, 16.06 278.85, 56.4 -55.46, -28.11 in-in in 9.0339 Saltbr-in 2.8992 HRD-in -94.66, -56.81 78.16, -3.52 in-in-in SNCiii in-in ActLoopNT-in 2.9853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.51, 155.2 APE9-dihe-na 137.51, -153.75 APE8-dihe-in -125.49, 136.2 APE8-rot-in 297.83 APE67-dihe-in -73.46, -24.38 -35.73, -51.43 APE12-dist-in 7.9972 APE11-dist-in 11.4183 APE10-dist-in 5.7664 APE9-dist-in 3.6421 None TPO198 TPO198 XRAY 2.0 0.197 999.0 A 350.0 343.0 0 25 25 0 [[44, 298]] 1.0 1cdk Sus scrofa AGC_PRKACA_PIG AGC 3.5e-95 324.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_PIG 1CDKB P36887 9 351 351.0 ANP:60400 ATPlike Active DFGin 5.907 14.5106 BLAminus -124.27, -171.72 50.82, 76.29 -83.58, 17.26 280.88, 62.25 -47.74, -29.83 in-in in 8.889 Saltbr-in 2.8833 HRD-in -87.48, -57.48 77.49, 1.67 in-in-in SNCiii in-in ActLoopNT-in 2.9631 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.91, 159.84 APE9-dihe-na 137.3, -140.74 APE8-dihe-in -136.57, 132.27 APE8-rot-in 304.84 APE67-dihe-in -69.16, -27.96 -34.59, -53.92 APE12-dist-in 8.3483 APE11-dist-in 11.5142 APE10-dist-in 6.0801 APE9-dist-in 3.7441 None TPO198 TPO198 XRAY 2.0 0.197 999.0 B 350.0 343.0 0 25 25 0 [[44, 298]] 1.0 1cdk Sus scrofa AGC_PRKACA_PIG AGC 3.5e-95 324.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
OTHER RNASEL A5H025_PIG 4O1PA A5H025 22 729 743.0 ANP:901,25L:904 ATPlike,Allosteric Inactive DFGin 6.5106 12.9603 ABAminus -131.33, -33.02 -113.57, 101.31 -107.24, 17.35 306.62, 95.87 -64.46, -18.71 in-in in 7.0246 Saltbr-in 2.5592 HRD-in -60.39, -60.51 77.09, -8.47 in-in-na SNCiia in-na ActLoopNT-in 2.8318 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -142.96, 83.14 APE9-dihe-na -58.16, -26.45 APE8-dihe-na -61.31, -25.89 APE8-rot-na 201.37 APE67-dihe-na -54.23, -32.66 -72.61, -17.63 APE12-dist-na 15.865 APE11-dist-na 12.9589 APE10-dist-na 13.1315 APE9-dist-na 13.8672 None None None XRAY 2.5 0.198 0.231 A 717.0 672.0 4 20 20 0 [[351, 591]] 1.0 4o1p Sus scrofa OTHER_RNASEL_PIG RNASEL 2.2e-128 433.7 1.0 242.0 242.0 499 500 501 503 505 390 402 406 479 481 480 482.0 517 519 514 513 512 511 510 509 508 433 Ribonuclease L
OTHER RNASEL A5H025_PIG 4O1PB A5H025 22 729 743.0 ANP:901,25L:904 ATPlike,Allosteric Inactive DFGin 6.5583 12.9326 ABAminus -131.25, -34.01 -112.79, 101.17 -107.11, 16.68 306.49, 96.02 -64.91, -18.59 in-in in 7.0347 Saltbr-in 2.5611 HRD-in -55.77, -50.97 68.09, -3.12 in-in-na SNCiia in-na ActLoopNT-in 2.8687 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -144.24, 83.66 APE9-dihe-na -56.74, -27.11 APE8-dihe-na -62.19, -25.6 APE8-rot-na 202.01 APE67-dihe-na -55.19, -32.83 -72.11, -17.43 APE12-dist-na 15.8375 APE11-dist-na 12.884 APE10-dist-na 13.1268 APE9-dist-na 13.6898 None None None XRAY 2.5 0.198 0.231 B 717.0 671.0 3 20 20 0 [[351, 591]] 1.0 4o1p Sus scrofa OTHER_RNASEL_PIG RNASEL 2.2e-128 433.7 1.0 242.0 242.0 499 500 501 503 505 390 402 406 479 481 480 482.0 517 519 514 513 512 511 510 509 508 433 Ribonuclease L
OTHER RNASEL A5H025_PIG 4O1PC A5H025 22 729 743.0 ANP:901,25L:904 ATPlike,Allosteric Inactive DFGin 6.5736 12.9509 ABAminus -131.64, -33.31 -113.88, 102.15 -109.17, 16.76 306.25, 95.79 -63.9, -18.81 in-in in 7.0356 Saltbr-in 2.5563 HRD-in -57.15, -62.34 78.43, -4.0 in-in-na SNCiia in-na ActLoopNT-in 2.8402 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -142.78, 82.89 APE9-dihe-na -56.9, -26.71 APE8-dihe-na -61.49, -26.14 APE8-rot-na 201.42 APE67-dihe-na -54.45, -32.57 -72.46, -17.58 APE12-dist-na 15.8741 APE11-dist-na 12.9723 APE10-dist-na 13.1218 APE9-dist-na 13.7065 None None None XRAY 2.5 0.198 0.231 C 717.0 673.0 4 20 20 0 [[351, 591]] 1.0 4o1p Sus scrofa OTHER_RNASEL_PIG RNASEL 2.2e-128 433.7 1.0 242.0 242.0 499 500 501 503 505 390 402 406 479 481 480 482.0 517 519 514 513 512 511 510 509 508 433 Ribonuclease L
OTHER RNASEL A5H025_PIG 4O1PD A5H025 22 729 743.0 ANP:901,25L:904 ATPlike,Allosteric Inactive DFGin 6.5223 12.9182 ABAminus -132.11, -32.85 -113.92, 101.55 -106.16, 16.67 306.88, 96.47 -66.56, -17.9 in-in in 7.0247 Saltbr-in 2.5581 HRD-in -66.2, -51.02 69.27, -3.45 in-in-na SNCiia in-na ActLoopNT-in 2.837 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -143.98, 84.27 APE9-dihe-na -56.61, -27.19 APE8-dihe-na -61.86, -25.69 APE8-rot-na 201.6 APE67-dihe-na -54.63, -32.79 -72.23, -18.0 APE12-dist-na 15.8126 APE11-dist-na 12.7951 APE10-dist-na 13.0985 APE9-dist-na 13.6043 None None None XRAY 2.5 0.198 0.231 D 717.0 668.0 5 20 20 0 [[351, 591]] 1.0 4o1p Sus scrofa OTHER_RNASEL_PIG RNASEL 2.2e-128 433.7 1.0 242.0 242.0 499 500 501 503 505 390 402 406 479 481 480 482.0 517 519 514 513 512 511 510 509 508 433 Ribonuclease L
OTHER TCUR0376 D1A2F7_THECD 8CAVA D1A2F7 6 865 865.0 ANP:61003 Allosteric Inactive DFGout 25.0288 13.8059 None -136.61, -176.07 50.55, 90.07 -109.52, 39.53 298.71, 97.0 -61.52, -45.79 out-na out 23.3041 Saltbr-na 999.0 HRD-in -69.88, -46.85 69.44, -25.22 na-in-out SNCaio in-out ActLoopNT-in 3.0456 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na 151.19, 133.67 APE9-dihe-na -156.32, 163.61 APE8-dihe-in -115.94, 119.26 APE8-rot-in 286.11 APE67-dihe-inflip 85.43, -34.6 -53.57, 131.45 APE12-dist-out 4.1645 APE11-dist-in 8.3427 APE10-dist-in 6.3115 APE9-dist-in 5.6421 None None None XRAY 2.87 0.24 0.293 A 865.0 860.0 0 23 23 0 [[216, 447]] 1.0 8cav Thermomonospora curvata OTHER_TCUR0376_THECD OTHER 2.3e-11 51.4 3.0 202.0 200.0 367 368 369 371 373 245 255 255 346 348 347 349.0 402 390 385 384 383 382 381 380 379 255 Serine/threonine protein kinase
OTHER TCUR0376 D1A2F7_THECD 8CAVB D1A2F7 6 863 865.0 ANP:61102 Allosteric Inactive DFGout 25.219 13.2725 None -136.17, 0.21 -151.94, 106.25 -116.71, 46.61 337.45, 77.06 -61.98, -44.38 out-na out 23.2159 Saltbr-na 999.0 HRD-in -72.63, -51.39 72.73, -38.34 na-in-out SNCaio in-out ActLoopNT-in 3.126 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na 155.97, 136.86 APE9-dihe-na -156.68, 147.71 APE8-dihe-in -106.12, 118.89 APE8-rot-in 302.92 APE67-dihe-inflip 84.82, -43.75 -50.92, 139.58 APE12-dist-out 4.0314 APE11-dist-in 8.2152 APE10-dist-in 6.5289 APE9-dist-in 5.9687 None None None XRAY 2.87 0.24 0.293 B 865.0 858.0 0 23 23 0 [[216, 447]] 1.0 8cav Thermomonospora curvata OTHER_TCUR0376_THECD OTHER 2.3e-11 51.4 3.0 202.0 200.0 367 368 369 371 373 245 255 255 346 348 347 349.0 402 390 385 384 383 382 381 380 379 255 Serine/threonine protein kinase
CAMK CDPK1 Q9BJF5_TOXGO 4IEBA Q9BJF5 32 507 507.0 ANP:60605 ATPlike Inactive DFGin 6.5537 15.7608 BLAminus -118.12, -178.54 57.22, 81.05 -93.39, 22.31 283.83, 75.07 -62.91, -21.06 out-out out 10.7859 Saltbr-out 8.1831 HRD-in -78.1, -52.4 75.27, -1.01 out-in-in SNCoii in-in ActLoopNT-in 2.9719 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.38, 132.65 APE9-dihe-na 150.75, -159.18 APE8-dihe-in -127.81, 136.94 APE8-rot-in 296.09 APE67-dihe-in -59.35, -29.22 -49.66, -52.18 APE12-dist-in 8.747 APE11-dist-in 11.8763 APE10-dist-in 6.0733 APE9-dist-in 3.6857 G128M None None XRAY 2.05 0.176 0.217 A 515.0 471.0 4 27 27 0 [[51, 308]] 1.0 4ieb Toxoplasma gondii CAMK_CDPK1_TOXGO CAMK 1.4e-91 312.8 1.0 256.0 256.0 194 195 196 198 200 80 99 103 171 173 172 174.0 232 221 216 215 214 213 212 211 210 129 non-specific serine/threonine protein kinase
CAMK CDPK1 Q9BJF5_TOXGO 3HX4A Q9BJF5 30 503 507.0 ANP:605 ATPlike Inactive DFGin 6.3758 15.5972 BLAminus -124.93, -178.11 57.55, 76.18 -93.17, 21.06 281.41, 72.38 -57.25, -28.44 out-out out 10.4296 Saltbr-out 8.0819 HRD-in -82.41, -52.5 74.03, -1.03 out-in-in SNCoii in-in ActLoopNT-in 2.926 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.23, 136.25 APE9-dihe-na 150.35, -156.09 APE8-dihe-in -126.64, 138.87 APE8-rot-in 302.17 APE67-dihe-in -62.12, -29.95 -51.48, -47.24 APE12-dist-in 8.5825 APE11-dist-in 12.0547 APE10-dist-in 6.1884 APE9-dist-in 3.6455 None None None XRAY 1.95 0.212 0.257 A 508.0 467.0 7 27 27 0 [[51, 308]] 1.0 3hx4 Toxoplasma gondii CAMK_CDPK1_TOXGO CAMK 5.2e-90 307.5 1.0 256.0 256.0 194 195 196 198 200 80 99 103 171 173 172 174.0 232 221 216 215 214 213 212 211 210 129 non-specific serine/threonine protein kinase
CAMK CDPK1 Q9BJF5_TOXGO 3KU2A Q9BJF5 44 507 507.0 ANP:508 ATPlike Inactive None 11.4771 17.9385 None -100.99, 156.17 73.53, 18.21 -64.25, 133.09 244.39, 100.2 75.66, -4.53 out-none out 14.4969 Saltbr-none 999.0 HRD-in -80.49, -57.8 77.94, -40.26 none-out-out SNCnoo out-out ActLoopNT-out 5.7208 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -61.85, 129.57 APE9-dihe-na 74.83, 23.66 APE8-dihe-out -106.17, -37.64 APE8-rot-out 63.52 APE67-dihe-in -62.81, -37.67 -61.55, -28.62 APE12-dist-out 14.0548 APE11-dist-out 16.6555 APE10-dist-out 19.0687 APE9-dist-out 12.0419 None None None XRAY 2.3 0.198 0.236 A 507.0 457.0 0 27 27 0 [[51, 308]] 1.0 3ku2 Toxoplasma gondii CAMK_CDPK1_TOXGO CAMK 5.2e-90 307.5 1.0 256.0 256.0 194 195 196 198 200 80 99 103 171 173 172 174.0 232 221 216 215 214 213 212 211 210 129 non-specific serine/threonine protein kinase
OTHER ROP18 ROP18_TOXGO 4JRNA Q2PAY2 187 548 554.0 ANP:601 Allosteric None DFGin 8.9824 15.8688 BLAminus -128.68, -167.44 58.76, 57.13 -87.53, 25.8 281.08, 82.06 -67.92, -21.93 in-in in 8.1829 Saltbr-in 2.9919 HRD-in -70.13, -31.0 63.02, -2.32 in-in-none SNCiin in-none ActLoopNT-in 2.3841 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_inni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 178.51 APE8-dihe-in -78.23, 127.04 APE8-rot-in 289.7 APE67-dihe-inflip 110.21, -8.27 -63.71, 127.69 APE12-dist-in 10.0073 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.2757 None None None XRAY 2.71 0.235 0.289 A 372.0 349.0 6 24 22 2 [[253, 531]] 1.0 4jrn Toxoplasma gondii OTHER_ROP18_TOXGO CAMK 0.04 76.6 5.0 55.0 197.0 426 427 428 430 432 281 300 304 406 408 407 409.0 465 450 445 444 443 442 441 440 439 0 Serine/threonine-protein kinase ROP18
OTHER PINK1 PINK1_TRICA 5YJ9D D6WMX4 166 570 570.0 ANP:601 ATPlike Inactive DFGin 9.5017 15.2831 ABAminus -117.37, -38.64 -95.18, 97.77 -99.2, 13.92 280.74, 77.89 -62.77, -17.79 in-in in 7.8359 Saltbr-in 2.5799 HRD-out -70.37, 137.63 -130.59, 22.41 in-in-out SNCiio in-out ActLoopNT-in 2.5791 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_iiii APE10-dihe-na -154.61, -176.52 APE9-dihe-na -54.92, 113.48 APE8-dihe-in -53.26, 148.57 APE8-rot-na 309.64 APE67-dihe-out -106.62, -9.97 -172.9, 165.52 APE12-dist-in 7.9748 APE11-dist-in 11.272 APE10-dist-in 7.1591 APE9-dist-in 3.2168 S205D,S377D,T386E,T530E None MSE197,MSE198,MSE208,MSE214,MSE223,MSE288,MSE294,MSE328,MSE380,MSE389 XRAY 2.53 0.23 0.243 D 423.0 343.0 56 34 34 0 [[61, 504]] 1.0 5yj9 Tribolium castaneum OTHER_PINK1_TRICA PINK1 5.8e-86 294.6 5.0 367.0 363.0 358 359 360 362 364 196 217 221 334 336 335 337.0 410 392 387 386 385 384 383 382 381 295 Serine/threonine-protein kinase Pink1, mitochondrial
CMGC TVAG125560 A2F9N1_TRIV3 9AV7A A2F9N1 15 318 320.0 ANP:401 ATPlike Active DFGin 7.6357 16.4242 BLAminus -120.42, -177.29 61.53, 69.44 -89.47, 18.08 296.84, 80.84 -66.47, -28.11 in-in in 9.4621 Saltbr-in 3.0921 HRD-in -77.85, -46.91 69.04, 9.93 in-in-in SNCiii in-in ActLoopNT-in 2.9544 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.39, -177.21 APE9-dihe-na 62.4, -175.9 APE8-dihe-in -115.65, 153.97 APE8-rot-in 297.25 APE67-dihe-inflip 82.79, -6.3 -53.46, 134.7 APE12-dist-in 12.6952 APE11-dist-in 10.4962 APE10-dist-in 6.3173 APE9-dist-in 3.0126 None None None XRAY 2.1 0.202 0.246 A 328.0 304.0 0 27 27 0 [[27, 312]] 1.0 9av7 Trichomonas vaginalis CMGC_TVAG125560_TRIV3 CMGC 2.3e-51 180.8 1.0 301.0 301.0 162 163 164 166 168 56 69 73 141 143 142 144.0 202 189 184 183 182 181 180 179 178 102 non-specific serine/threonine protein kinase
CAMK AURKBA AUKBA_XENLA 4C2WA Q6DE08 88 356 361.0 ANP:1001 ATPlike Inactive DFGin 5.5245 15.7899 ABAminus -114.94, -31.28 -113.37, 121.43 -114.18, 23.33 282.52, 84.1 -51.89, -43.92 out-out out 11.2684 Saltbr-out 4.9732 HRD-in -79.83, -53.41 73.71, 4.05 out-in-in SNCoii in-in ActLoopNT-in 2.893 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.21, 165.55 APE9-dihe-na 112.48, -144.66 APE8-dihe-in -138.33, 133.06 APE8-rot-in 294.04 APE67-dihe-in -66.35, -18.01 -34.41, -59.11 APE12-dist-in 8.359 APE11-dist-in 10.9412 APE10-dist-in 5.5314 APE9-dist-in 3.5614 None TPO248 TPO248 XRAY 1.7 0.158 0.195 A 279.0 269.0 0 26 26 0 [[93, 343]] 1.0 4c2w Xenopus laevis CAMK_AURKBA_XENLA CAMK 2.3e-77 265.7 1.0 256.0 256.0 233 234 235 237 239 122 141 145 213 215 214 216.0 271 259 254 253 252 251 250 249 248 171 Aurora kinase B-A
CAMK AURKBA AUKBA_XENLA 4C2WB Q6DE08 78 355 361.0 ANP:1002 ATPlike Inactive DFGin 5.81 15.7867 ABAminus -118.01, -19.02 -130.42, 119.39 -114.99, 28.58 284.95, 75.85 -64.5, -21.38 out-out out 10.7632 Saltbr-out 4.7398 HRD-in -76.03, -52.74 71.93, -3.36 out-in-in SNCoii in-in ActLoopNT-in 2.9194 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.86, 167.53 APE9-dihe-na 123.0, -151.95 APE8-dihe-in -138.83, 132.09 APE8-rot-in 301.48 APE67-dihe-in -63.95, -21.5 -45.73, -54.15 APE12-dist-in 8.0417 APE11-dist-in 10.7689 APE10-dist-in 5.3227 APE9-dist-in 3.6059 None TPO248 TPO248 XRAY 1.7 0.158 0.195 B 279.0 278.0 0 26 26 0 [[93, 343]] 1.0 4c2w Xenopus laevis CAMK_AURKBA_XENLA CAMK 2.3e-77 265.7 1.0 256.0 256.0 233 234 235 237 239 122 141 145 213 215 214 216.0 271 259 254 253 252 251 250 249 248 171 Aurora kinase B-A
CMGC ACK2 CSK2A_MAIZE 1DAWA P28523 2 328 332.0 ANP:60340 ATPlike Inactive DFGin 7.4789 16.2531 BLAminus -105.07, -177.02 59.3, 78.28 -93.62, 17.81 300.8, 85.23 -64.69, -25.71 in-in in 9.0445 Saltbr-in 2.6139 HRD-in -71.54, -56.91 74.99, 12.33 in-in-out SNCiio in-out ActLoopNT-in 2.6533 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -145.67, 164.1 APE9-dihe-na 63.95, 166.03 APE8-dihe-in -78.9, 151.56 APE8-rot-out 157.17 APE67-dihe-in -65.06, -18.37 -51.17, -45.02 APE12-dist-in 12.4577 APE11-dist-in 10.113 APE10-dist-in 6.0173 APE9-dist-in 3.0963 None None None XRAY 2.2 0.223 0.285 A 327.0 327.0 0 27 27 0 [[34, 319]] 1.0 1daw Zea mays CMGC_ACK2_MAIZE CMGC 1.7e-65 227.1 1.0 301.0 301.0 169 170 171 173 175 63 76 80 148 150 149 151.0 209 196 191 190 189 188 187 186 185 109 Casein kinase II subunit alpha
CMGC ACK2 CSK2A_MAIZE 1LP4A P28523 2 328 332.0 ANP:60340 ATPlike Inactive DFGin 7.3844 16.4369 BLAminus -105.48, -174.19 57.32, 75.68 -95.1, 15.33 299.18, 80.31 -67.7, -16.27 in-in in 8.951 Saltbr-in 2.9287 HRD-in -74.21, -49.64 68.44, 10.87 in-in-out SNCiio in-out ActLoopNT-in 2.7917 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.52, 168.08 APE9-dihe-na 65.54, 161.64 APE8-dihe-in -72.4, 142.48 APE8-rot-out 152.04 APE67-dihe-in -70.58, -15.11 -42.33, -45.49 APE12-dist-in 12.4105 APE11-dist-in 10.0413 APE10-dist-in 6.0356 APE9-dist-in 3.1383 None None None XRAY 1.86 0.207 0.244 A 332.0 327.0 0 27 27 0 [[34, 319]] 1.0 1lp4 Zea mays CMGC_ACK2_MAIZE CMGC 1.8e-65 227.0 1.0 301.0 301.0 169 170 171 173 175 63 76 80 148 150 149 151.0 209 196 191 190 189 188 187 186 185 109 Casein kinase II subunit alpha
OTHER SIRK1 K7VIQ3_MAIZE 5UV4A K7VIQ3 744 1045 1045.0 ANP:1101 ATPlike Pseudo DFGin 4.8784 12.8015 BLBplus -120.34, 177.7 46.93, 54.84 -91.14, 142.45 62.71, 98.99 59.6, 31.25 out-out out 15.1466 Saltbr-out 17.5322 HRD-in -68.43, -62.74 80.25, -5.53 out-out-out SNCooo out-out ActLoopNT-out 7.1596 ActLoopCT-out nonTYR APEdihe_aaono APEdist_oioo APE10-dihe-na -63.26, -37.61 APE9-dihe-na -61.51, -44.79 APE8-dihe-out -63.05, -40.24 APE8-rot-none 999.0 APE67-dihe-out 86.33, 22.47 -82.94, -6.82 APE12-dist-out 14.6572 APE11-dist-in 12.4356 APE10-dist-out 11.8497 APE9-dist-out 10.4225 None None None XRAY 2.3 0.184 0.211 A 311.0 290.0 12 29 29 0 [[757, 1042]] 1.0 5uv4 Zea mays OTHER_SIRK1_MAIZE TKL 1.6e-38 138.7 5.0 265.0 261.0 906 907 908 910 912 789 805 809 885 887 886 888.0 949 935 930 929 928 927 926 925 924 837 Putative leucine-rich repeat protein kinase family protein

Ligand: ANP

Total number of chains: 142
Active chains: 40
Total number of genes: 50
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 71 50.0% 4S32A
DFGin ABAminus 18 12.7% 4C2WA
DFGin BLBplus 18 12.7% 7CTXB
DFGin None 13 9.2% 2VWBA
None None 9 6.3% 4IX5A
DFGin BLBminus 6 4.2% 7CTVA
DFGout None 4 2.8% 4I94A
DFGin BLBtrans 3 2.1% 5W7TA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CKA1 CSK21_ARATH 6XX7A Q08467 77 406 409.0 ANP:60401 ATPlike Active DFGin 7.5219 16.0536 BLAminus -117.69, -174.69 54.04, 89.21 -108.75, 22.96 298.46, 82.8 -72.45, -17.87 in-in in 9.1971 Saltbr-in 3.1105 HRD-in -78.14, -48.74 65.41, 21.05 in-in-in SNCiii in-in ActLoopNT-in 2.8345 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.12, 170.49 APE9-dihe-na 62.76, -171.63 APE8-dihe-in -114.91, 151.01 APE8-rot-in 304.83 APE67-dihe-in -66.49, -17.41 -50.66, -50.22 APE12-dist-in 12.5854 APE11-dist-in 10.2831 APE10-dist-in 6.1876 APE9-dist-in 3.1341 None None None XRAY 2.4 0.198 0.246 A 342.0 330.0 0 27 27 0 [[110, 395]] 1.0 6xx7 Arabidopsis thaliana CMGC_CKA1_ARATH CMGC 2.6e-65 226.5 1.0 301.0 301.0 245 246 247 249 251 139 152 156 224 226 225 227.0 285 272 267 266 265 264 263 262 261 185 Casein kinase II subunit alpha-1
CMGC MPK4 MPK4_ARATH 7W5CA Q39024 18 372 376.0 ANP:401 ATPlike Inactive DFGin 6.7443 16.2248 BLAminus -128.66, -171.29 63.4, 64.26 -92.17, 14.29 279.32, 65.56 -68.22, -18.9 in-in in 9.0096 Saltbr-in 3.5788 HRD-in -71.53, -46.63 78.29, -8.64 in-in-out SNCiio in-out ActLoopNT-in 2.7029 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -115.93, 157.72 APE9-dihe-na -84.69, 1.94 APE8-dihe-in -132.03, 98.21 APE8-rot-out 46.99 APE67-dihe-in -68.07, -19.68 -80.43, -5.49 APE12-dist-out 6.2327 APE11-dist-in 10.9036 APE10-dist-out 8.9788 APE9-dist-out 11.6743 None None None XRAY 2.201 0.179 0.225 A 355.0 355.0 0 27 27 0 [[44, 329]] 1.0 7w5c Arabidopsis thaliana CMGC_MPK4_ARATH CMGC 1.3e-82 283.5 4.0 301.0 298.0 186 187 188 190 192 72 90 94 166 168 167 169.0 226 213 208 207 206 205 204 203 202 125 Mitogen-activated protein kinase 4
OTHER BSK8 BSK8_ARATH 4I94A Q9FHD7 40 328 487.0 ANP:60401 ATPlike Pseudo DFGout 11.0871 4.5792 None -62.85, 129.32 -64.9, -25.87 -61.66, -30.07 297.42, 140.17 -78.36, -1.16 out-out out 12.4918 Saltbr-out 11.1684 HRD-naV -138.88, 128.41 -94.79, 85.21 out-out-out SNCooo out-out ActLoopNT-out 8.1156 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -112.72, -1.39 APE9-dihe-na -99.73, 174.6 APE8-dihe-in -44.04, 124.87 APE8-rot-na 191.2 APE67-dihe-in -63.8, -11.97 -65.3, -25.56 APE12-dist-in 9.6511 APE11-dist-in 13.0353 APE10-dist-out 13.7384 APE9-dist-out 9.019 None None None XRAY 1.8 0.176 0.218 A 300.0 289.0 0 24 24 0 [[64, 311]] 1.0 4i94 Arabidopsis thaliana OTHER_BSK8_ARATH TKL 1.8e-32 119.0 14.0 264.0 251.0 198 199 200 202 204 87 103 107 178 180 179 181.0 234 222 217 216 215 214 213 212 211 133 Serine/threonine-protein kinase BSK8
OTHER BSK8 BSK8_ARATH 4I94B Q9FHD7 40 328 487.0 ANP:60401 ATPlike Pseudo DFGout 11.1674 4.5637 None -61.22, 131.83 -70.76, -19.93 -64.01, -28.32 298.7, 142.58 -77.56, -3.78 out-out out 12.6104 Saltbr-out 11.5622 HRD-naV -138.23, 125.02 -91.22, 87.17 out-out-out SNCooo out-out ActLoopNT-out 8.121 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -107.48, -5.73 APE9-dihe-na -87.26, 179.81 APE8-dihe-in -41.52, 121.65 APE8-rot-na 191.74 APE67-dihe-in -60.71, -19.43 -60.4, -25.91 APE12-dist-in 9.6381 APE11-dist-in 12.9661 APE10-dist-out 14.1361 APE9-dist-out 9.0483 None None None XRAY 1.8 0.176 0.218 B 300.0 289.0 0 24 24 0 [[64, 311]] 1.0 4i94 Arabidopsis thaliana OTHER_BSK8_ARATH TKL 1.8e-32 119.0 14.0 264.0 251.0 198 199 200 202 204 87 103 107 178 180 179 181.0 234 222 217 216 215 214 213 212 211 133 Serine/threonine-protein kinase BSK8
TKL BAK1 BAK1_ARATH 3UIMA Q94F62 272 573 615.0 ANP:1000 ATPlike Inactive DFGin 8.8521 13.2065 BLAminus -115.13, -165.77 41.37, 88.34 -98.5, 43.81 308.93, 97.2 -70.58, -44.49 in-out in 8.2806 Saltbr-out 5.242 HRD-in -79.94, -53.3 85.37, -6.05 out-in-none SNCoin in-none ActLoopNT-in 2.6407 ActLoopCT-none nonTYR APEdihe_aaini APEdist_iiii APE10-dihe-na -138.37, 177.14 APE9-dihe-na 106.88, -163.48 APE8-dihe-in -113.09, 162.35 APE8-rot-none 999.0 APE67-dihe-in -50.4, -34.12 -54.05, -40.71 APE12-dist-in 10.9122 APE11-dist-in 11.3003 APE10-dist-in 7.4138 APE9-dist-in 5.3194 None SEP290,TPO312,TPO446,TPO449,TPO450,TPO455 SEP290,TPO312,TPO446,TPO449,TPO450,TPO455 XRAY 2.2 0.237 0.277 A 326.0 297.0 5 29 29 0 [[288, 565]] 1.0 3uim Arabidopsis thaliana TKL_BAK1_ARATH TKL 5.8e-64 222.2 4.0 266.0 263.0 433 434 435 437 439 317 334 338 413 415 414 416.0 474 462 457 456 455 454 453 452 451 364 BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1
TKL BRI1 BRI1_ARATH 5LPVA O22476 867 1160 1196.0 ANP:1200 ATPlike Active DFGin 5.1436 14.9992 BLAminus -125.7, -177.27 57.44, 79.7 -100.2, 28.83 289.11, 69.34 -64.8, -27.23 in-in in 8.6162 Saltbr-in 2.6924 HRD-in -72.39, -48.96 69.78, 4.25 in-in-in SNCiii in-in ActLoopNT-in 2.9727 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.4, 152.93 APE9-dihe-na 138.14, -175.87 APE8-dihe-in -122.84, 131.25 APE8-rot-in 310.37 APE67-dihe-inflip 103.25, -12.92 -53.02, 126.73 APE12-dist-in 9.4988 APE11-dist-in 11.4352 APE10-dist-in 5.6666 APE9-dist-in 3.6712 T872A TPO1039,SEP1042,SEP1044 TPO1039,SEP1042,SEP1044 XRAY 2.7 0.193 0.233 A 296.0 285.0 9 30 30 0 [[882, 1157]] 1.0 5lpv Arabidopsis thaliana TKL_BRI1_ARATH TKL 2e-63 220.4 4.0 266.0 263.0 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009.0 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL BRI1 BRI1_ARATH 4OH4A O22476 863 1160 1196.0 ANP:61201 ATPlike Active DFGin 5.1089 14.6209 BLAminus -140.27, -170.9 60.42, 81.58 -96.75, 17.94 285.65, 72.49 -62.14, -24.45 in-in in 8.4295 Saltbr-in 2.9805 HRD-in -67.48, -45.07 71.79, 0.23 in-in-in SNCiii in-in ActLoopNT-in 2.8706 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.28, 137.25 APE9-dihe-na 143.97, 175.71 APE8-dihe-in -113.05, 131.41 APE8-rot-in 300.18 APE67-dihe-inflip 103.6, -22.59 -52.56, 134.8 APE12-dist-in 10.6878 APE11-dist-in 12.0604 APE10-dist-in 6.3282 APE9-dist-in 4.1239 None TPO1039,SEP1042,SEP1044,SEP1060 TPO1039,SEP1042,SEP1044,SEP1060 XRAY 2.25 0.203 0.236 A 333.0 292.0 6 30 30 0 [[882, 1157]] 1.0 4oh4 Arabidopsis thaliana TKL_BRI1_ARATH TKL 3e-63 219.8 4.0 266.0 263.0 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009.0 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL BRI1 BRI1_ARATH 4OH4B O22476 867 1160 1196.0 ANP:61201 ATPlike Active DFGin 5.0282 14.8658 BLAminus -128.92, -179.57 66.05, 81.1 -97.08, 13.19 285.07, 69.22 -52.61, -27.46 in-in in 8.6041 Saltbr-in 2.5854 HRD-in -68.96, -46.37 73.67, -10.15 in-in-in SNCiii in-in ActLoopNT-in 2.8697 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.43, 142.85 APE9-dihe-na 162.33, 170.81 APE8-dihe-in -132.62, 128.73 APE8-rot-in 297.7 APE67-dihe-inflip 104.71, -30.59 -48.41, 132.44 APE12-dist-in 9.4708 APE11-dist-in 10.3111 APE10-dist-in 5.1462 APE9-dist-in 4.0534 None TPO1039,SEP1042,SEP1044,SEP1060 TPO1039,SEP1042,SEP1044,SEP1060 XRAY 2.25 0.203 0.236 B 333.0 283.0 11 30 30 0 [[882, 1157]] 1.0 4oh4 Arabidopsis thaliana TKL_BRI1_ARATH TKL 3e-63 219.8 4.0 266.0 263.0 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009.0 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL BRI1 BRI1_ARATH 4Q5JA O22476 863 1160 1196.0 ANP:61201 ATPlike Active DFGin 5.0658 14.7399 BLAminus -137.9, 174.67 63.19, 85.3 -100.14, 20.42 284.87, 74.71 -62.5, -33.31 in-in in 8.3543 Saltbr-in 3.2574 HRD-in -68.22, -43.45 65.77, 3.93 in-in-in SNCiii in-in ActLoopNT-in 2.6621 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.48, 139.01 APE9-dihe-na 175.24, 173.84 APE8-dihe-in -115.42, 129.74 APE8-rot-in 289.59 APE67-dihe-inflip 96.87, -1.52 -53.59, 124.31 APE12-dist-in 10.51 APE11-dist-in 12.0649 APE10-dist-in 6.2358 APE9-dist-in 4.4668 None TPO1039,SEP1042,SEP1044,SEP1060 MSE925,MSE928,MSE959,MSE1010,MSE1030,MSE1034,MSE1037,TPO1039,SEP1042,SEP1044,SEP1060,MSE1117,MSE1148,MSE1152,MSE1154 XRAY 2.772 0.203 0.259 A 341.0 287.0 11 30 30 0 [[882, 1157]] 1.0 4q5j Arabidopsis thaliana TKL_BRI1_ARATH TKL 3.2e-63 219.7 4.0 266.0 263.0 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009.0 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL BRI1 BRI1_ARATH 4Q5JB O22476 867 1160 1196.0 ANP:61201 ATPlike Active DFGin 5.2589 14.7995 BLAminus -126.47, -178.56 58.45, 93.89 -112.89, 22.9 283.23, 71.66 -57.4, -19.56 in-in in 8.7318 Saltbr-in 3.1836 HRD-in -81.55, -35.96 67.72, -5.15 in-in-in SNCiii in-in ActLoopNT-in 2.7754 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -167.14, 134.16 APE9-dihe-na 157.62, 164.27 APE8-dihe-in -126.08, 123.8 APE8-rot-in 304.99 APE67-dihe-inflip 120.44, -28.11 -46.98, 122.06 APE12-dist-in 9.4035 APE11-dist-in 10.6356 APE10-dist-in 5.5117 APE9-dist-in 4.0814 None TPO1039,SEP1042,SEP1044,SEP1060 MSE925,MSE928,MSE959,MSE1010,MSE1030,MSE1034,MSE1037,TPO1039,SEP1042,SEP1044,SEP1060,MSE1117,MSE1148,MSE1152,MSE1154 XRAY 2.772 0.203 0.259 B 341.0 283.0 11 30 30 0 [[882, 1157]] 1.0 4q5j Arabidopsis thaliana TKL_BRI1_ARATH TKL 3.2e-63 219.7 4.0 266.0 263.0 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009.0 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL CARK1 CARK1_ARATH 5XD6A Q9LUT0 50 350 364.0 ANP:61000 ATPlike Inactive DFGin 5.2866 13.9895 None -82.23, -179.6 -66.2, 154.72 -113.7, 177.91 45.1, 88.76 -91.38, 112.57 out-na out 13.41 Saltbr-na 13.4762 HRD-in -67.99, -48.34 77.3, -6.84 na-out-none SNCaon out-none ActLoopNT-out 8.2956 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 12.83 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.898 0.218 0.251 A 305.0 278.0 23 30 13 17 [[67, 347]] 1.0 5xd6 Arabidopsis thaliana TKL_CARK1_ARATH TKL 9e-61 211.7 4.0 266.0 263.0 216 217 218 220 222 97 112 116 196 198 197 199.0 258 246 241 240 239 238 237 236 235 142 Protein CYTOSOLIC ABA RECEPTOR KINASE 1
TKL CARK1 CARK1_ARATH 5XD6B Q9LUT0 50 350 364.0 ANP:61000 ATPlike Inactive DFGin 5.6295 13.9302 None -77.44, -177.16 -70.67, 157.78 -117.63, 177.11 50.67, 89.87 -85.72, 109.22 out-na out 13.6757 Saltbr-na 14.0861 HRD-in -75.16, -46.81 74.28, -9.17 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -2.12 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.898 0.218 0.251 B 305.0 282.0 19 30 11 19 [[67, 347]] 1.0 5xd6 Arabidopsis thaliana TKL_CARK1_ARATH TKL 9e-61 211.7 4.0 266.0 263.0 216 217 218 220 222 97 112 116 196 198 197 199.0 258 246 241 240 239 238 237 236 235 142 Protein CYTOSOLIC ABA RECEPTOR KINASE 1
TKL SOBIR1 SBIR1_ARATH 7CTVA Q9SKB2 326 639 641.0 ANP:60702 ATPlike Inactive DFGin 6.6608 13.8853 BLBminus -141.13, -179.6 54.72, 58.77 -66.01, 150.7 286.65, 72.17 -81.72, 124.12 out-none out 15.112 Saltbr-none 999.0 HRD-out -87.3, 102.63 -86.62, 6.82 none-out-out SNCnoo out-out ActLoopNT-out 9.5209 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -76.63, -5.1 APE9-dihe-na 65.07, 35.87 APE8-dihe-out -126.08, 24.51 APE8-rot-out 59.01 APE67-dihe-in -54.76, -18.48 -67.58, -32.17 APE12-dist-out 20.7618 APE11-dist-out 20.4915 APE10-dist-out 17.1794 APE9-dist-out 13.9703 D489A None None XRAY 2.886 0.218 0.239 A 336.0 297.0 17 30 30 0 [[343, 638]] 1.0 7ctv Arabidopsis thaliana TKL_SOBIR1_ARATH TKL 8.4e-57 198.7 4.0 266.0 263.0 506 507 508 510 512 377 407 411 486 488 487 489.0 548 536 531 530 529 528 527 526 525 437 Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1
TKL SOBIR1 SBIR1_ARATH 7CTVB Q9SKB2 326 640 641.0 ANP:60702 ATPlike Inactive DFGin 6.421 13.8703 BLBminus -144.86, -178.02 49.22, 64.23 -62.65, 147.84 294.25, 70.22 -69.54, 92.84 out-none out 15.2531 Saltbr-none 999.0 HRD-out -90.69, 89.36 -71.79, -21.49 none-out-out SNCnoo out-out ActLoopNT-out 9.1207 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -77.41, -5.23 APE9-dihe-na 69.76, 25.67 APE8-dihe-out -112.95, 17.98 APE8-rot-out 72.42 APE67-dihe-in -62.91, -23.09 -65.66, -31.24 APE12-dist-out 20.1323 APE11-dist-out 19.7591 APE10-dist-out 16.4315 APE9-dist-out 13.6326 D489A None None XRAY 2.886 0.218 0.239 B 336.0 292.0 23 30 30 0 [[343, 638]] 1.0 7ctv Arabidopsis thaliana TKL_SOBIR1_ARATH TKL 8.4e-57 198.7 4.0 266.0 263.0 506 507 508 510 512 377 407 411 486 488 487 489.0 548 536 531 530 529 528 527 526 525 437 Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1
TKL SOBIR1 SBIR1_ARATH 7CTXA Q9SKB2 326 639 641.0 ANP:60701 ATPlike Inactive DFGin 5.9245 13.9577 BLBplus -138.51, 171.55 56.64, 47.79 -120.23, 164.88 60.27, 92.94 88.0, -43.52 out-out out 14.426 Saltbr-out 14.6199 HRD-in -69.62, -53.51 75.07, -7.08 out-out-out SNCooo out-out ActLoopNT-out 8.647 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -78.29, -6.92 APE9-dihe-na 74.92, 27.29 APE8-dihe-out -123.12, 22.17 APE8-rot-out 54.06 APE67-dihe-in -63.92, -13.63 -66.83, -19.82 APE12-dist-out 21.8717 APE11-dist-out 21.4602 APE10-dist-out 18.2821 APE9-dist-out 14.1209 None None None XRAY 2.907 0.226 0.243 A 323.0 293.0 8 30 30 0 [[343, 638]] 1.0 7ctx Arabidopsis thaliana TKL_SOBIR1_ARATH TKL 1.3e-59 207.9 4.0 266.0 263.0 506 507 508 510 512 377 407 411 486 488 487 489.0 548 536 531 530 529 528 527 526 525 437 Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1
TKL SOBIR1 SBIR1_ARATH 7CTXB Q9SKB2 326 640 641.0 ANP:60701 ATPlike Inactive DFGin 5.8751 13.9927 BLBplus -137.44, 176.16 58.26, 44.88 -125.18, 162.12 65.68, 87.66 87.14, -0.96 out-out out 14.0627 Saltbr-out 13.6314 HRD-in -66.8, -55.86 75.55, -4.98 out-out-out SNCooo out-out ActLoopNT-out 8.8498 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -76.44, -5.32 APE9-dihe-na 71.29, 28.46 APE8-dihe-out -125.93, 28.87 APE8-rot-out 53.38 APE67-dihe-in -62.75, -12.89 -73.08, -23.74 APE12-dist-out 21.6184 APE11-dist-out 21.3279 APE10-dist-out 18.1913 APE9-dist-out 14.3165 None None None XRAY 2.907 0.226 0.243 B 323.0 297.0 5 30 30 0 [[343, 638]] 1.0 7ctx Arabidopsis thaliana TKL_SOBIR1_ARATH TKL 1.3e-59 207.9 4.0 266.0 263.0 506 507 508 510 512 377 407 411 486 488 487 489.0 548 536 531 530 529 528 527 526 525 437 Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1
AGC PRKACA KAPCA_BOVIN 9DW5G P00517 13 351 351.0 ANP:403 ATPlike None DFGin 7.3339 15.8767 BLAminus -126.22, -169.89 60.75, 61.77 -87.02, 21.16 273.51, 93.96 -63.0, -33.74 out-none out 10.2523 Saltbr-none 999.0 HRD-in -80.85, -56.62 73.43, -6.68 none-in-in SNCnii in-in ActLoopNT-in 2.7819 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -167.11, -173.97 APE9-dihe-na 106.0, -157.25 APE8-dihe-in -108.29, 136.12 APE8-rot-in 326.0 APE67-dihe-in -63.46, -43.06 -59.57, -33.75 APE12-dist-in 9.1133 APE11-dist-in 11.9553 APE10-dist-in 6.8101 APE9-dist-in 4.5632 None TPO198 TPO198 EM 3.8 999.0 999.0 G 351.0 330.0 0 25 25 0 [[44, 298]] 1.0 9dw5 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 9DW8G P00517 15 329 351.0 ANP:403 ATPlike None DFGin 6.0696 14.2353 BLAminus -131.43, -174.72 59.27, 66.66 -86.28, 33.46 293.19, 93.28 -61.23, -49.05 in-none in 9.9111 Saltbr-none 999.0 HRD-in -98.32, -49.71 57.42, 11.15 none-in-in SNCnii in-in ActLoopNT-in 2.9612 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -168.06, 160.73 APE9-dihe-na 123.3, -175.7 APE8-dihe-in -89.52, 132.72 APE8-rot-in 298.44 APE67-dihe-in -69.93, -27.98 -56.75, -38.6 APE12-dist-in 8.7001 APE11-dist-in 11.5933 APE10-dist-in 6.4109 APE9-dist-in 4.8026 None TPO198 TPO198 EM 3.5 999.0 999.0 G 351.0 309.0 0 25 25 0 [[44, 298]] 1.0 9dw8 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 9DW7G P00517 13 351 351.0 ANP:403 ATPlike Inactive None 999.0 999.0 None -155.4, -162.2 59.11, 63.62 -70.57, 12.19 999.0, 999.0 -65.51, -34.83 out-none out 10.9713 Saltbr-none 999.0 HRD-in -65.14, -55.26 50.7, 27.28 none-in-out SNCnio in-out ActLoopNT-in 2.5754 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iiio APE10-dihe-na -166.96, 170.69 APE9-dihe-na 108.98, -156.8 APE8-dihe-in -102.79, 139.06 APE8-rot-none 999.0 APE67-dihe-in -58.63, -28.81 -67.98, -6.96 APE12-dist-in 9.2283 APE11-dist-in 10.2672 APE10-dist-in 6.4383 APE9-dist-out 6.202 None None None EM 6.0 999.0 999.0 G 351.0 339.0 0 25 25 0 [[44, 298]] 1.0 9dw7 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
TYR LET23 LET23_CAEEL 5WNOA P24348 876 1190 1323.0 ANP:1201 ATPlike Inactive DFGin 6.2472 12.8766 BLBplus -129.17, 177.47 55.99, 43.49 -103.44, 159.44 53.09, 86.5 67.88, 29.06 out-out out 14.4646 Saltbr-out 14.5171 HRD-in -74.41, -38.75 70.96, -11.0 out-out-out SNCooo out-out ActLoopNT-out 7.6383 ActLoopCT-out TYR APEdihe_nooai APEdist_aaao APE10-dihe-none 999.0, -139.66 APE9-dihe-out -62.23, -13.83 APE8-dihe-out -67.85, 10.53 APE8-rot-na 999.0 APE67-dihe-in -61.61, -23.35 -63.66, -29.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.694 APE9-dist-out 10.8591 None None None XRAY 2.386 0.217 0.247 A 330.0 302.0 13 30 18 12 [[885, 1143]] 1.0 5wno Caenorhabditis elegans TYR_LET23_CAEEL TYR 1.6e-78 269.6 2.0 260.0 259.0 1027 1028 1029 1031 1033 919 934 938 1007 1009 1008 1010.0 1069 1057 1052 1051 1050 1049 1048 1047 1046 964 Receptor tyrosine-protein kinase let-23
CMGC CK2 Q5KF69_CRYD1 6ISEA Q5KF69 5 331 336.0 ANP:403 ATPlike Active DFGin 7.3392 16.2078 BLAminus -129.3, -170.99 44.36, 71.77 -91.05, 22.67 299.01, 82.29 -66.02, -23.99 in-in in 9.4822 Saltbr-in 3.3362 HRD-in -65.48, -54.09 76.82, 9.27 in-in-in SNCiii in-in ActLoopNT-in 2.9136 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.0, -19.23 APE9-dihe-na -99.69, -172.72 APE8-dihe-in -80.09, 147.5 APE8-rot-in 301.93 APE67-dihe-in -61.24, -16.59 -47.75, -58.81 APE12-dist-in 12.6869 APE11-dist-in 10.6311 APE10-dist-in 6.1443 APE9-dist-in 3.6087 None None None XRAY 2.8 0.198 0.23 A 338.0 327.0 0 27 27 0 [[38, 323]] 1.0 6ise Cryptococcus deneoformans CMGC_CK2_CRYD1 CMGC 6e-64 222.0 1.0 301.0 301.0 173 174 175 177 179 67 80 84 152 154 153 155.0 213 200 195 194 193 192 191 190 189 113 Casein kinase II subunit alpha
CMGC CK2 Q5KF69_CRYD1 6ISEB Q5KF69 5 331 336.0 ANP:403 ATPlike Active DFGin 7.3075 16.2384 BLAminus -133.11, -171.48 44.36, 73.35 -91.98, 23.51 299.28, 79.86 -68.68, -21.78 in-in in 9.5908 Saltbr-in 3.4961 HRD-in -67.7, -51.8 75.87, 7.92 in-in-in SNCiii in-in ActLoopNT-in 2.9761 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.38, 168.0 APE9-dihe-na 74.76, -173.48 APE8-dihe-in -110.86, 148.66 APE8-rot-in 271.82 APE67-dihe-in -65.62, -23.31 -54.68, -45.78 APE12-dist-in 12.5765 APE11-dist-in 10.3109 APE10-dist-in 6.2661 APE9-dist-in 3.3672 None None None XRAY 2.8 0.198 0.23 B 338.0 327.0 0 27 27 0 [[38, 323]] 1.0 6ise Cryptococcus deneoformans CMGC_CK2_CRYD1 CMGC 6e-64 222.0 1.0 301.0 301.0 173 174 175 177 179 67 80 84 152 154 153 155.0 213 200 195 194 193 192 191 190 189 113 Casein kinase II subunit alpha
CMGC CKA1 J9VNH4_CRYN9 6KO6B J9VNH4 5 334 338.0 ANP:401 ATPlike Active DFGin 7.2981 16.2364 BLAminus -115.02, -165.9 52.87, 72.55 -94.97, 21.12 299.2, 77.23 -71.99, -18.35 in-in in 9.3237 Saltbr-in 3.1512 HRD-in -64.53, -49.64 63.27, 19.41 in-in-in SNCiii in-in ActLoopNT-in 3.0553 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.45, 156.98 APE9-dihe-na 76.83, -179.82 APE8-dihe-in -92.38, 159.35 APE8-rot-in 277.62 APE67-dihe-in -71.62, -13.46 -53.06, -52.26 APE12-dist-in 12.7924 APE11-dist-in 10.4743 APE10-dist-in 6.1773 APE9-dist-in 3.2488 None None None XRAY 2.4 0.238 0.268 B 338.0 330.0 0 27 27 0 [[38, 323]] 1.0 6ko6 Cryptococcus neoformans CMGC_CKA1_CRYN9 CMGC 6e-64 222.0 1.0 301.0 301.0 173 174 175 177 179 67 80 84 152 154 153 155.0 213 200 195 194 193 192 191 190 189 113 Casein kinase II subunit alpha
CAMK CDPK1 A3FQ16_CRYPI 3IGOA A3FQ16 70 537 538.0 ANP:60610 ATPlike Inactive DFGin 6.7066 13.4651 BLBplus -121.25, 174.97 67.47, 60.04 -154.02, 168.86 59.26, 84.09 92.58, -14.73 out-out out 14.2087 Saltbr-out 13.0649 HRD-in -63.43, -55.21 83.61, -21.71 out-out-out SNCooo out-out ActLoopNT-out 9.0298 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 153.6 APE8-rot-out 169.15 APE67-dihe-in -51.84, -35.84 -53.96, -31.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.25 0.205 0.258 A 486.0 445.0 8 27 20 7 [[76, 332]] 1.0 3igo Cryptosporidium parvum CAMK_CDPK1_CRYPI CAMK 3.4e-90 308.1 1.0 256.0 256.0 218 219 220 222 224 105 123 127 195 197 196 198.0 256 245 240 239 238 237 236 235 234 153 non-specific serine/threonine protein kinase
CAMK CDPK3 Q5CS01_CRYPI 3LIJA Q5CS01 42 516 523.0 ANP:60522 ATPlike Inactive DFGin 7.0342 14.6546 BLAminus -127.46, 177.5 59.13, 85.54 -100.29, 19.94 282.89, 79.61 -59.37, -32.9 out-out out 10.177 Saltbr-out 5.2556 HRD-in -74.61, -49.83 71.32, -4.41 out-in-in SNCoii in-in ActLoopNT-in 2.9357 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.48, 149.72 APE9-dihe-na 141.55, -153.66 APE8-dihe-in -128.1, 132.61 APE8-rot-in 307.4 APE67-dihe-in -65.62, -35.53 -34.47, -55.78 APE12-dist-in 8.691 APE11-dist-in 11.6597 APE10-dist-in 5.7815 APE9-dist-in 3.5691 None None None XRAY 1.9 0.203 0.229 A 494.0 461.0 8 27 27 0 [[62, 318]] 1.0 3lij Cryptosporidium parvum CAMK_CDPK3_CRYPI CAMK 2.7e-91 311.6 1.0 256.0 256.0 204 205 206 208 210 91 109 113 181 183 182 184.0 242 231 226 225 224 223 222 221 220 139 Calcium-dependent protein kinase 1
CAMK CDPK4-2 Q5CZ29_CRYPI 3HKOA Q5CZ29 126 452 824.0 ANP:60329 ATPlike Inactive DFGin 5.9519 15.5829 ABAminus -120.43, 2.55 -135.28, 127.73 -128.94, 23.59 286.29, 84.57 -62.1, -26.95 out-out out 10.1114 Saltbr-out 4.4341 HRD-in -76.09, -50.74 72.63, 1.72 out-in-out SNCoio in-out ActLoopNT-in 2.7733 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, -104.24 APE9-dihe-na 126.39, -179.13 APE8-dihe-in -75.92, 124.68 APE8-rot-in 280.37 APE67-dihe-in -53.45, -34.89 -49.78, -39.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.4056 APE9-dist-in 3.7216 None None None XRAY 1.8 0.204 0.246 A 345.0 314.0 13 32 24 8 [[135, 237], [261, 441]] 2.0 3hko Cryptosporidium parvum CAMK_CDPK4-2_CRYPI CAMK 1.5e-19 241.1 1.0 89.0 250.0 319 320 321 323 325 164 185 189 297 299 298 300.0 365 351 346 345 344 343 342 341 340 215 non-specific serine/threonine protein kinase
CMGC BSK JNK_DROME 5AWMA P92208 7 362 372.0 ANP:401 ATPlike Inactive DFGin 3.9678 14.3041 ABAminus -88.58, -21.58 -138.57, 174.5 -114.07, -2.87 300.82, 95.37 86.6, -153.47 out-out out 10.4287 Saltbr-out 5.2581 HRD-in -75.17, -58.38 75.26, -11.27 out-out-out SNCooo out-out ActLoopNT-out 6.3567 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -11.69 APE9-dihe-na -122.62, 142.03 APE8-dihe-in -71.85, 116.06 APE8-rot-in 300.48 APE67-dihe-in -65.6, -18.22 -112.19, 0.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.382 APE9-dist-out 11.1663 None None None XRAY 1.79 0.179 0.22 A 394.0 345.0 9 27 24 3 [[24, 320]] 1.0 5awm Drosophila melanogaster CMGC_BSK_DROME CMGC 8.1e-82 280.8 1.0 301.0 301.0 166 167 168 170 172 53 71 75 146 148 147 149.0 205 193 188 187 186 185 184 183 182 107 Stress-activated protein kinase JNK
STE DSOR1 DSOR1_DROME 8BW9C Q24324 81 384 396.0 ANP:60401,QOM:60402 ATPlike,Type3 Inactive DFGin 5.4773 14.249 BLBplus -159.47, 168.77 62.79, 56.43 -107.18, 135.07 48.27, 89.36 -64.21, 107.83 out-out out 15.5585 Saltbr-out 19.8405 HRD-in -58.37, -64.17 71.81, -9.38 out-out-out SNCooo out-out ActLoopNT-out 8.8494 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -115.48, -57.78 APE9-dihe-na 75.76, 170.55 APE8-dihe-out -89.06, -0.85 APE8-rot-out 170.28 APE67-dihe-out -125.12, 142.75 -125.31, 123.31 APE12-dist-out 17.3843 APE11-dist-out 19.5261 APE10-dist-out 21.9991 APE9-dist-out 14.6441 None None None EM 3.32 999.0 999.0 C 396.0 280.0 24 26 26 0 [[87, 364]] 1.0 8bw9 Drosophila melanogaster STE_DSOR1_DROME STE 2.5e-90 308.3 2.0 256.0 255.0 226 227 228 230 232 116 133 137 206 208 207 209.0 264 252 247 246 245 244 243 242 241 163 Dual specificity mitogen-activated protein kinase kinase dSOR1
TYR PTK2 FAK1_CHICK 2J0LA Q00944 411 686 1053.0 ANP:1689 ATPlike Inactive DFGin 7.0415 15.5948 BLAminus -124.12, -151.88 51.86, 82.15 -108.03, 32.91 286.36, 85.03 -71.96, -36.63 in-in in 7.8243 Saltbr-in 2.777 HRD-in -78.92, -53.9 78.76, -8.92 in-in-out SNCiio in-out ActLoopNT-in 2.9564 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -71.98, 100.38 APE9-dihe-in -65.3, 130.79 APE8-dihe-in -75.31, 71.06 APE8-rot-na 28.66 APE67-dihe-in -69.29, -16.82 -49.9, -41.21 APE12-dist-na 11.3874 APE11-dist-na 10.2564 APE10-dist-na 13.5329 APE9-dist-out 8.2789 None PTR576,PTR577 PTR576,PTR577 XRAY 2.3 0.217 0.263 A 276.0 276.0 0 29 29 0 [[422, 678]] 1.0 2j0l Gallus gallus TYR_PTK2_CHICK TYR 2.6e-93 318.0 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 6TY4A Q00944 34 686 1053.0 ANP:702 ATPlike Active DFGin 7.5465 15.9507 BLAminus -124.05, -151.88 51.86, 82.13 -107.99, 32.9 286.39, 85.0 -72.01, -36.58 in-in in 8.4374 Saltbr-in 3.5618 HRD-in -70.16, -30.0 74.19, -18.38 in-in-in SNCiii in-in ActLoopNT-in 2.8146 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.31, 66.54 APE9-dihe-in -63.31, 139.75 APE8-dihe-in -64.41, 127.23 APE8-rot-na 22.65 APE67-dihe-in -56.19, -42.03 -70.19, -41.73 APE12-dist-na 11.4889 APE11-dist-na 10.1836 APE10-dist-na 13.6359 APE9-dist-in 7.205 None None None EM 5.96 999.0 999.0 A 658.0 621.0 0 29 29 0 [[422, 678]] 1.0 6ty4 Gallus gallus TYR_PTK2_CHICK TYR 1.5e-91 312.7 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 6TY4B Q00944 34 686 1053.0 ANP:702 ATPlike Active DFGin 7.5463 15.9503 BLAminus -124.03, -151.9 51.82, 82.14 -107.99, 32.89 286.33, 85.06 -71.97, -36.56 in-in in 8.4362 Saltbr-in 3.562 HRD-in -70.15, -30.0 74.26, -18.38 in-in-in SNCiii in-in ActLoopNT-in 2.8146 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.3, 66.56 APE9-dihe-in -63.34, 139.79 APE8-dihe-in -64.42, 127.23 APE8-rot-na 22.65 APE67-dihe-in -56.21, -42.01 -70.19, -41.71 APE12-dist-na 11.4889 APE11-dist-na 10.1834 APE10-dist-na 13.6363 APE9-dist-in 7.2047 None None None EM 5.96 999.0 999.0 B 658.0 621.0 0 29 29 0 [[422, 678]] 1.0 6ty4 Gallus gallus TYR_PTK2_CHICK TYR 1.5e-91 312.7 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
OTHER LPL0262 Q5WZW9_LEGPL 5CKWA Q5WZW9 15 404 961.0 ANP:60501 ATPlike Active DFGin 5.9476 12.719 BLAminus -133.44, 169.43 70.28, 94.79 -117.83, 12.87 299.33, 117.8 -55.88, -8.97 in-in in 6.7101 Saltbr-in 2.7162 HRD-naQ -80.53, -48.66 73.11, 5.26 in-in-in SNCiii in-in ActLoopNT-in 2.9268 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -69.26, -22.18 APE9-dihe-na -101.55, 179.41 APE8-dihe-in -117.11, 122.15 APE8-rot-in 302.21 APE67-dihe-in -64.67, -9.61 -57.44, -37.84 APE12-dist-in 11.7619 APE11-dist-in 9.7088 APE10-dist-in 4.6475 APE9-dist-in 3.3467 None None None XRAY 2.49 0.207 0.258 A 451.0 378.0 5 25 25 0 [[75, 309]] 1.0 5ckw Legionella pneumophila OTHER_LPL0262_LEGPL NEK 4.8e-15 62.8 10.0 222.0 213.0 212 213 214 216 218 104 119 123 192 194 193 195.0 249 237 232 231 230 229 228 227 226 146 non-specific serine/threonine protein kinase
OTHER LPL0262 Q5WZW9_LEGPL 5CKWB Q5WZW9 1 404 961.0 ANP:60501 ATPlike Active DFGin 6.1888 12.6735 BLAminus -144.06, 165.73 65.65, 85.18 -109.61, 21.73 306.46, 113.14 -57.87, -17.2 in-in in 6.7686 Saltbr-in 2.8816 HRD-naQ -82.05, -45.94 73.24, -7.24 in-in-in SNCiii in-in ActLoopNT-in 2.9759 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -76.56, -19.65 APE9-dihe-na -103.71, -175.8 APE8-dihe-in -130.62, 116.65 APE8-rot-in 293.03 APE67-dihe-in -65.48, -28.87 -48.06, -39.07 APE12-dist-in 11.5294 APE11-dist-in 9.5863 APE10-dist-in 4.4834 APE9-dist-in 3.4581 None None None XRAY 2.49 0.207 0.258 B 451.0 399.0 5 25 25 0 [[75, 309]] 1.0 5ckw Legionella pneumophila OTHER_LPL0262_LEGPL NEK 4.8e-15 62.8 10.0 222.0 213.0 212 213 214 216 218 104 119 123 192 194 193 195.0 249 237 232 231 230 229 228 227 226 146 non-specific serine/threonine protein kinase
CMGC MAPK A0A3Q8ITZ9_LEIDO 4QNYA A0A3Q8ITZ9 4 350 408.0 ANP:402 ATPlike Inactive DFGin 6.1648 14.7035 BLAminus -127.76, -174.94 61.93, 78.26 -95.74, 34.98 293.98, 91.09 -76.44, -18.02 in-in in 9.3477 Saltbr-in 2.7287 HRD-in -68.82, -45.36 71.54, -13.83 in-in-out SNCiio in-out ActLoopNT-in 2.7408 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oooo APE10-dihe-na -132.18, 155.62 APE9-dihe-na -94.67, -21.05 APE8-dihe-in -141.24, 100.95 APE8-rot-na 183.02 APE67-dihe-in -68.06, -10.3 -112.98, 4.12 APE12-dist-out 16.0225 APE11-dist-out 14.6699 APE10-dist-out 11.6896 APE9-dist-out 12.5673 None None None XRAY 2.257 0.237 0.285 A 354.0 333.0 3 28 25 3 [[21, 310]] 1.0 4qny Leishmania donovani CMGC_MAPK_LEIDO CMGC 5.8e-75 258.3 3.0 301.0 299.0 166 167 168 170 172 51 70 74 146 148 147 149.0 207 194 189 188 187 186 185 184 183 105 Mitogen activated protein kinase, putative
CMGC MAPK A0A3Q8ITZ9_LEIDO 4QNYB A0A3Q8ITZ9 4 350 408.0 ANP:403 ATPlike Inactive DFGin 6.1377 14.7888 BLAminus -126.8, -176.12 61.38, 78.86 -95.33, 36.88 294.2, 91.77 -77.29, -21.88 in-in in 9.4534 Saltbr-in 2.8308 HRD-in -69.33, -48.45 68.04, -9.32 in-in-out SNCiio in-out ActLoopNT-in 2.5807 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oooo APE10-dihe-na -133.75, 152.71 APE9-dihe-na -90.5, -19.94 APE8-dihe-in -141.35, 99.54 APE8-rot-na 186.55 APE67-dihe-in -67.94, -11.27 -112.59, 3.99 APE12-dist-out 16.1485 APE11-dist-out 14.7495 APE10-dist-out 11.6845 APE9-dist-out 12.6418 None None None XRAY 2.257 0.237 0.285 B 354.0 339.0 2 28 26 2 [[21, 310]] 1.0 4qny Leishmania donovani CMGC_MAPK_LEIDO CMGC 5.8e-75 258.3 3.0 301.0 299.0 166 167 168 170 172 51 70 74 146 148 147 149.0 207 194 189 188 187 186 185 184 183 105 Mitogen activated protein kinase, putative
TKL LYK3 LYK3_MEDTR 9GFZA Q6UD73 302 596 620.0 ANP:601 ATPlike Inactive DFGin 5.8955 16.3194 BLBtrans -112.0, 159.57 61.3, 42.0 -77.09, 135.77 153.85, 71.13 82.14, -2.66 out-out out 14.7946 Saltbr-out 16.343 HRD-in -69.33, -37.57 70.07, -2.36 out-out-out SNCooo out-out ActLoopNT-out 6.107 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -140.09, 130.62 APE9-dihe-na 119.67, 164.52 APE8-dihe-in -118.67, 135.65 APE8-rot-in 301.27 APE67-dihe-inflip 89.4, -18.92 -56.77, 138.93 APE12-dist-out 14.646 APE11-dist-in 13.0792 APE10-dist-out 9.1944 APE9-dist-in 4.3087 D459N None None XRAY 2.5 0.211 0.257 A 296.0 288.0 7 29 25 4 [[321, 594]] 1.0 9gfz Medicago truncatula TKL_LYK3_MEDTR TKL 3.5e-59 206.5 3.0 264.0 262.0 458 459 460 462 464 349 362 366 438 440 439 441.0 499 487 482 481 480 479 478 477 476 391 LysM domain receptor-like kinase 3
TKL LYR4 G7K7K0_MEDTR 8PS7B G7K7K0 340 636 660.0 ANP:703 ATPlike Pseudo DFGin 7.7676 15.0657 BLBminus -155.57, -174.44 55.36, 56.3 -70.81, 152.24 289.97, 66.8 93.85, 156.74 out-out out 15.9615 Saltbr-out 14.036 HRD-in -57.6, -55.05 79.6, -10.79 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -72.46, -42.72 APE9-dihe-na -56.2, -52.66 APE8-dihe-out -56.27, -29.69 APE8-rot-out 59.05 APE67-dihe-in -100.31, -14.89 -66.25, -40.12 APE12-dist-in 9.7023 APE11-dist-in 13.6472 APE10-dist-out 15.2433 APE9-dist-out 9.612 None None None XRAY 2.1 0.225 0.269 B 297.0 274.0 23 33 21 12 [[360, 633]] 1.0 8ps7 Medicago truncatula TKL_LYR4_MEDTR TKL 4.9e-53 186.3 13.0 266.0 254.0 493 494 495 497 499 379 388 392 473 475 474 476.0 538 526 521 520 519 518 517 516 515 418 LysM-domain receptor-like kinase
TKL LYR4 G7K7K0_MEDTR 8PS7A G7K7K0 340 636 660.0 ANP:704 ATPlike Pseudo DFGin 7.3438 12.4911 None -132.7, -71.23 -80.99, 65.77 -101.31, -4.53 43.9, 75.68 -166.17, 141.69 out-out out 12.6635 Saltbr-out 13.161 HRD-in -67.54, -63.16 83.85, -10.66 out-out-out SNCooo out-out ActLoopNT-out 9.632 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -64.12, -49.62 APE9-dihe-na -62.67, -34.57 APE8-dihe-out -58.19, -50.78 APE8-rot-in 276.77 APE67-dihe-in -82.12, -28.85 -67.98, -32.83 APE12-dist-out 14.2466 APE11-dist-out 19.2311 APE10-dist-out 20.4004 APE9-dist-out 9.2958 None None None XRAY 2.1 0.225 0.269 A 297.0 279.0 18 33 33 0 [[360, 633]] 1.0 8ps7 Medicago truncatula TKL_LYR4_MEDTR TKL 4.9e-53 186.3 13.0 266.0 254.0 493 494 495 497 499 379 388 392 473 475 474 476.0 538 526 521 520 519 518 517 516 515 418 LysM-domain receptor-like kinase
OTHER BUD32 KAE1B_METJA 2VWBA Q58530 1 530 535.0 ANP:1531 Allosteric Inactive DFGin 6.8437 17.1317 None -120.64, -3.56 -136.03, 137.71 -148.58, 37.82 232.34, 113.93 -66.32, -14.47 in-in in 7.9752 Saltbr-in 2.7284 HRD-out -83.04, 140.14 -107.29, 16.57 in-in-na SNCiia in-na ActLoopNT-in 2.9164 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -66.96, -33.04 APE9-dihe-na -68.59, -42.86 APE8-dihe-na -73.15, -19.01 APE8-rot-na 294.55 APE67-dihe-na -59.99, -36.61 -63.88, -52.94 APE12-dist-na 17.0179 APE11-dist-na 12.319 APE10-dist-na 14.9692 APE9-dist-na 11.6624 None None None XRAY 3.05 0.224 0.301 A 535.0 519.0 4 23 23 0 [[334, 534]] 1.0 2vwb Methanocaldococcus jannaschii OTHER_BUD32_METJA TP53RK 8.5e-45 159.9 6.0 218.0 213.0 466 467 468 470 472 360 384 388 448 450 449 451.0 483 489 484 483 482 481 480 479 478 414 Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
OTHER BUD32 KAE1B_METJA 2VWBB Q58530 1 532 535.0 ANP:1533 Allosteric Inactive DFGin 6.5797 16.7156 None -128.01, -5.24 -139.71, 160.08 -157.9, 25.33 238.13, 113.59 -41.68, -37.13 in-in in 7.8464 Saltbr-in 3.1753 HRD-out -90.81, 128.03 -91.65, 20.67 in-in-na SNCiia in-na ActLoopNT-in 2.657 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -74.1, -29.36 APE9-dihe-na -76.07, -42.12 APE8-dihe-na -69.9, -15.57 APE8-rot-na 312.74 APE67-dihe-na -42.13, -37.17 -74.66, -63.72 APE12-dist-na 16.6492 APE11-dist-na 12.1119 APE10-dist-na 14.818 APE9-dist-na 11.4755 None None None XRAY 3.05 0.224 0.301 B 535.0 507.0 8 23 23 0 [[334, 534]] 1.0 2vwb Methanocaldococcus jannaschii OTHER_BUD32_METJA TP53RK 8.5e-45 159.9 6.0 218.0 213.0 466 467 468 470 472 360 384 388 448 450 449 451.0 483 489 484 483 482 481 480 479 478 414 Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
OTHER STT7 C1EBN1_MICCC 4IX5A C1EBN1 151 489 489.0 ANP:60603 none Inactive None 999.0 999.0 None -120.9, 168.56 71.67, 80.19 -91.21, 21.79 297.99, 161.42 -64.36, -22.18 none-na none 999.0 Saltbr-na 999.0 HRD-na- -71.12, -47.17 73.28, 1.59 na-in-none SNCain in-none ActLoopNT-in 2.9126 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.178 0.201 A 350.0 339.0 0 -337 -337 0 [[62, 488]] 1.0 4ix5 Micromonas commoda OTHER_STT7_MICCC CMGC 1.3e-08 61.8 104.0 156.0 81.0 337 338 339 341 343 0 0 0 315 317 316 318.0 0 0 0 0 0 0 0 0 0 0 Protein kinase domain-containing protein
OTHER STT7 C1EBN1_MICCC 4IX5B C1EBN1 151 489 489.0 ANP:60602 none Inactive None 999.0 999.0 None -122.9, 169.14 69.98, 79.33 -89.65, 21.35 295.31, 157.7 -65.22, -20.9 none-na none 999.0 Saltbr-na 999.0 HRD-na- -70.35, -44.14 70.61, 3.11 na-in-none SNCain in-none ActLoopNT-in 2.9407 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.178 0.201 B 350.0 339.0 0 -337 -337 0 [[62, 488]] 1.0 4ix5 Micromonas commoda OTHER_STT7_MICCC CMGC 1.3e-08 61.8 104.0 156.0 81.0 337 338 339 341 343 0 0 0 315 317 316 318.0 0 0 0 0 0 0 0 0 0 0 Protein kinase domain-containing protein
AGC PRKACA KAPCA_MOUSE 6MM6C P05132 19 351 351.0 ANP:60402 ATPlike Inactive DFGin 6.7799 16.0821 ABAminus -110.74, -8.1 -141.78, 125.75 -126.67, 17.79 291.81, 81.75 -52.6, -43.19 out-out out 10.4027 Saltbr-out 4.4909 HRD-in -64.73, -48.52 44.91, 28.18 out-in-out SNCoio in-out ActLoopNT-in 2.8769 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -155.16, 154.51 APE9-dihe-na 131.73, -155.42 APE8-dihe-in -119.09, 141.73 APE8-rot-out 198.33 APE67-dihe-in -57.79, -26.12 -45.84, -50.95 APE12-dist-in 8.5303 APE11-dist-in 11.8147 APE10-dist-in 6.3058 APE9-dist-in 4.5025 None TPO198,SEP339 TPO198,SEP339 XRAY 2.39 0.225 0.261 C 339.0 322.0 0 25 25 0 [[44, 298]] 1.0 6mm6 Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 6MM6E P05132 19 351 351.0 ANP:60401 ATPlike Inactive DFGin 6.7325 15.9653 ABAminus -112.26, -9.59 -137.74, 126.1 -127.73, 18.87 290.52, 82.39 -53.04, -44.19 out-out out 10.2709 Saltbr-out 5.278 HRD-in -66.74, -47.88 44.41, 27.02 out-in-out SNCoio in-out ActLoopNT-in 2.8731 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -157.27, 155.34 APE9-dihe-na 128.78, -154.8 APE8-dihe-in -120.26, 141.99 APE8-rot-out 197.33 APE67-dihe-in -57.79, -26.44 -45.46, -51.33 APE12-dist-in 8.4779 APE11-dist-in 11.8514 APE10-dist-in 6.3306 APE9-dist-in 4.4228 None TPO198,SEP339 TPO198,SEP339 XRAY 2.39 0.225 0.261 E 339.0 320.0 0 25 25 0 [[44, 298]] 1.0 6mm6 Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 6MM7A P05132 17 351 351.0 ANP:60406 ATPlike Inactive DFGin 6.7159 15.4284 ABAminus -112.23, -9.6 -137.01, 123.03 -130.15, 19.3 297.15, 81.39 -54.86, -42.58 out-out out 10.2821 Saltbr-out 4.6231 HRD-in -76.47, -53.66 52.13, 28.38 out-in-out SNCoio in-out ActLoopNT-in 2.8634 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -163.99, 161.65 APE9-dihe-na 126.52, -159.69 APE8-dihe-in -119.22, 141.71 APE8-rot-out 195.45 APE67-dihe-in -67.85, -20.3 -44.24, -48.26 APE12-dist-in 8.2035 APE11-dist-in 11.1251 APE10-dist-in 5.7383 APE9-dist-in 3.9708 None TPO198,SEP339 TPO198,SEP339 XRAY 1.85 0.213 0.238 A 339.0 327.0 0 25 25 0 [[44, 298]] 1.0 6mm7 Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 6MM7D P05132 16 351 351.0 ANP:60405 ATPlike Inactive DFGin 6.6517 15.4584 ABAminus -113.01, -9.74 -137.13, 123.49 -128.55, 17.46 296.74, 82.18 -52.99, -42.79 out-out out 10.3794 Saltbr-out 5.8168 HRD-in -73.81, -53.25 53.83, 26.23 out-in-out SNCoio in-out ActLoopNT-in 2.8742 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -166.02, 161.72 APE9-dihe-na 122.21, -160.7 APE8-dihe-in -119.01, 142.81 APE8-rot-out 192.42 APE67-dihe-in -67.72, -20.93 -42.31, -48.3 APE12-dist-in 8.2101 APE11-dist-in 11.2017 APE10-dist-in 5.7858 APE9-dist-in 3.9614 None TPO198,SEP339 TPO198,SEP339 XRAY 1.85 0.213 0.238 D 339.0 324.0 0 25 25 0 [[44, 298]] 1.0 6mm7 Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 6MM8C P05132 16 351 351.0 ANP:60403 ATPlike Inactive DFGin 6.6132 15.2001 ABAminus -113.8, -10.95 -132.36, 129.54 -134.0, 24.39 301.03, 83.83 -57.02, -38.35 out-out out 10.3401 Saltbr-out 7.3235 HRD-in -73.54, -53.96 54.41, 29.61 out-in-out SNCoio in-out ActLoopNT-in 2.7764 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -159.79, 167.54 APE9-dihe-na 115.95, -161.99 APE8-dihe-in -118.41, 142.14 APE8-rot-out 195.18 APE67-dihe-in -66.48, -19.98 -46.61, -45.65 APE12-dist-in 8.1252 APE11-dist-in 11.2017 APE10-dist-in 5.8341 APE9-dist-in 3.9965 None TPO198,SEP339 TPO198,SEP339 XRAY 1.85 0.183 0.221 C 339.0 325.0 0 25 25 0 [[44, 298]] 1.0 6mm8 Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 8UKND P05132 16 351 351.0 ANP:60400 ATPlike Inactive DFGin 6.6105 14.9582 ABAminus -121.75, -47.3 -93.55, 119.31 -121.12, 22.25 288.77, 83.91 -60.17, -43.74 in-out in 9.6363 Saltbr-out 4.003 HRD-in -71.48, -47.99 39.7, 38.93 out-in-in SNCoii in-in ActLoopNT-in 2.9756 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.1, 161.55 APE9-dihe-na 104.53, 169.82 APE8-dihe-in -72.88, 137.25 APE8-rot-in 280.42 APE67-dihe-in -60.56, -25.71 -55.68, -37.9 APE12-dist-in 8.0946 APE11-dist-in 11.2355 APE10-dist-in 5.8091 APE9-dist-in 4.6921 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.75 0.197 0.232 D 339.0 323.0 0 25 25 0 [[44, 298]] 1.0 8ukn Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 8UKOE P05132 16 351 351.0 ANP:60403 ATPlike Inactive DFGin 6.0364 14.5957 ABAminus -122.57, -57.22 -79.99, 109.96 -108.47, 33.73 286.2, 84.93 -64.54, -41.62 in-in in 9.7403 Saltbr-in 3.5644 HRD-in -78.91, -48.33 66.16, 13.52 in-in-in SNCiii in-in ActLoopNT-in 2.8677 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.15, 159.43 APE9-dihe-na 137.57, -133.12 APE8-dihe-in -144.28, 132.68 APE8-rot-in 289.09 APE67-dihe-in -62.87, -18.89 -48.53, -47.79 APE12-dist-in 8.0799 APE11-dist-in 11.3212 APE10-dist-in 5.8296 APE9-dist-in 3.774 None TPO198,SEP339 TPO198,SEP339 XRAY 2.89 0.213 0.259 E 339.0 336.0 0 25 25 0 [[44, 298]] 1.0 8uko Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 8UKPE P05132 17 351 351.0 ANP:60402 ATPlike Inactive DFGin 6.1336 14.4301 ABAminus -106.11, -56.02 -81.74, 124.54 -123.06, 18.4 279.21, 82.41 -57.4, -55.55 in-out in 9.2794 Saltbr-out 4.1807 HRD-in -89.57, -52.98 66.95, 19.28 out-in-in SNCoii in-in ActLoopNT-in 2.9525 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.29, 147.38 APE9-dihe-na 136.74, -150.06 APE8-dihe-in -126.21, 134.43 APE8-rot-in 318.02 APE67-dihe-in -77.56, -4.79 -54.58, -35.83 APE12-dist-in 7.9285 APE11-dist-in 10.8204 APE10-dist-in 5.1851 APE9-dist-in 3.8514 None SEP140,TPO198 SEP140,TPO198 XRAY 2.85 0.242 0.281 E 339.0 323.0 0 25 25 0 [[44, 298]] 1.0 8ukp Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 7E11A P05132 14 351 351.0 ANP:60401 ATPlike Active DFGin 6.205 14.4514 BLAminus -127.38, -169.19 58.28, 74.22 -96.53, 30.74 276.22, 81.09 -66.46, -21.72 in-in in 9.0533 Saltbr-in 2.5511 HRD-in -91.79, -53.23 62.57, 24.02 in-in-in SNCiii in-in ActLoopNT-in 3.1289 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.39, 155.98 APE9-dihe-na 134.96, -158.62 APE8-dihe-in -113.95, 132.34 APE8-rot-in 301.67 APE67-dihe-in -76.79, -1.28 -53.37, -39.68 APE12-dist-in 8.3091 APE11-dist-in 11.1349 APE10-dist-in 5.7098 APE9-dist-in 3.659 None TPO198,SEP339 TPO198,SEP339 XRAY 3.43 0.262 0.317 A 338.0 337.0 0 25 25 0 [[44, 298]] 1.0 7e11 Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 6MM5E P05132 16 351 351.0 ANP:60402 ATPlike Inactive DFGin 5.9604 14.3509 BLAminus -116.65, 159.11 76.02, 91.05 -92.83, 26.22 286.06, 88.09 -52.81, -36.86 in-in in 8.8493 Saltbr-in 2.8003 HRD-in -83.15, -50.88 72.11, -0.72 in-in-out SNCiio in-out ActLoopNT-in 2.8706 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -156.6, 159.33 APE9-dihe-na 129.67, -150.44 APE8-dihe-in -128.62, 141.57 APE8-rot-out 194.03 APE67-dihe-in -68.05, -20.18 -46.89, -45.89 APE12-dist-in 8.2074 APE11-dist-in 11.3781 APE10-dist-in 5.7976 APE9-dist-in 3.7765 None TPO198,SEP339 TPO198,SEP339 XRAY 1.95 0.183 0.227 E 339.0 336.0 0 25 25 0 [[44, 298]] 1.0 6mm5 Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3PVBA P05132 7 351 351.0 ANP:60400 ATPlike Active DFGin 5.2614 14.1066 BLAminus -138.85, 171.16 63.11, 82.89 -89.43, -59.95 273.17, 54.43 27.14, -66.26 in-in in 8.6853 Saltbr-in 3.4757 HRD-in -84.36, -35.8 62.24, -18.82 in-in-in SNCiii in-in ActLoopNT-in 3.2175 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -177.84, 157.88 APE9-dihe-na 132.55, -154.74 APE8-dihe-in -122.19, 108.01 APE8-rot-in 318.81 APE67-dihe-in -60.75, -2.24 -13.41, -60.33 APE12-dist-in 7.7331 APE11-dist-in 10.5794 APE10-dist-in 5.5109 APE9-dist-in 4.0421 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 3.3 0.242 0.29 A 345.0 345.0 0 25 25 0 [[44, 298]] 1.0 3pvb Mus musculus AGC_PRKACA_MOUSE AGC 1.4e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 2QCSA P05132 14 351 351.0 ANP:60400 ATPlike Active DFGin 5.648 14.2907 BLAminus -119.78, 176.88 65.56, 77.31 -85.05, 19.39 273.35, 51.28 -44.32, -42.51 in-in in 8.7843 Saltbr-in 2.6377 HRD-in -93.14, -54.78 73.52, 10.18 in-in-in SNCiii in-in ActLoopNT-in 2.7354 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.52, 149.74 APE9-dihe-na 148.64, -142.53 APE8-dihe-in -132.36, 132.12 APE8-rot-in 297.18 APE67-dihe-in -64.67, -25.45 -36.74, -53.73 APE12-dist-in 8.133 APE11-dist-in 11.3207 APE10-dist-in 5.8515 APE9-dist-in 3.5726 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.2 0.194 0.225 A 350.0 338.0 0 25 25 0 [[44, 298]] 1.0 2qcs Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3IDBA P05132 9 351 351.0 ANP:60450 ATPlike Active DFGin 5.3459 14.4126 BLAminus -121.17, -175.1 59.7, 79.28 -94.34, 24.01 267.69, 48.22 -48.56, -33.02 in-in in 8.8455 Saltbr-in 2.694 HRD-in -80.07, -50.75 69.18, 11.1 in-in-in SNCiii in-in ActLoopNT-in 2.9896 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.99, 160.5 APE9-dihe-na 138.4, -150.07 APE8-dihe-in -124.64, 132.33 APE8-rot-in 296.41 APE67-dihe-in -59.26, -21.93 -30.94, -63.4 APE12-dist-in 8.1019 APE11-dist-in 11.5726 APE10-dist-in 6.0684 APE9-dist-in 3.4448 None TPO198,SEP339 TPO198,SEP339 XRAY 1.62 0.206 0.23 A 350.0 343.0 0 25 25 0 [[44, 298]] 1.0 3idb Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3IDCA P05132 9 351 351.0 ANP:60450 ATPlike Active DFGin 5.079 14.4716 BLAminus -127.31, 174.57 68.22, 96.34 -111.15, 30.11 265.57, 49.45 -62.75, -22.0 in-in in 8.6423 Saltbr-in 3.0306 HRD-in -69.04, -44.03 64.09, 13.38 in-in-in SNCiii in-in ActLoopNT-in 2.8561 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.35, 157.69 APE9-dihe-na 142.7, -132.16 APE8-dihe-in -139.58, 115.88 APE8-rot-in 293.03 APE67-dihe-in -54.66, -5.54 -16.73, -78.3 APE12-dist-in 7.8437 APE11-dist-in 11.3725 APE10-dist-in 6.1644 APE9-dist-in 3.6752 None TPO198,SEP339 TPO198,SEP339 XRAY 2.7 0.241 0.319 A 350.0 343.0 0 25 25 0 [[44, 298]] 1.0 3idc Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DG0E P05132 11 351 351.0 ANP:60402 ATPlike Active DFGin 5.5834 14.3418 BLAminus -118.87, 179.66 65.44, 79.89 -93.34, 25.25 272.35, 58.42 -52.71, -36.39 in-in in 8.955 Saltbr-in 2.6989 HRD-in -84.35, -52.45 74.02, 7.32 in-in-in SNCiii in-in ActLoopNT-in 2.8946 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.07, 161.1 APE9-dihe-na 130.81, -146.6 APE8-dihe-in -130.07, 130.32 APE8-rot-in 303.85 APE67-dihe-in -61.09, -22.5 -44.14, -49.24 APE12-dist-in 8.0079 APE11-dist-in 11.4975 APE10-dist-in 5.8998 APE9-dist-in 3.3886 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.0 0.196 0.228 E 350.0 341.0 0 25 25 0 [[44, 298]] 1.0 4dg0 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DH7A P05132 16 351 351.0 ANP:60403 ATPlike Active DFGin 5.5738 14.3492 BLAminus -124.43, -175.45 59.33, 78.79 -93.54, 24.71 270.97, 54.79 -50.12, -38.03 in-in in 9.0247 Saltbr-in 2.7242 HRD-in -76.49, -50.79 66.5, 11.01 in-in-in SNCiii in-in ActLoopNT-in 2.9607 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.18, 162.39 APE9-dihe-na 131.3, -151.54 APE8-dihe-in -126.44, 134.15 APE8-rot-in 300.19 APE67-dihe-in -56.38, -25.77 -37.48, -60.34 APE12-dist-in 8.0928 APE11-dist-in 11.4546 APE10-dist-in 5.87 APE9-dist-in 3.4166 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.8 0.179 0.194 A 350.0 336.0 0 25 25 0 [[44, 298]] 1.0 4dh7 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DH8A P05132 16 351 351.0 ANP:60403 ATPlike Active DFGin 5.9006 14.014 BLAminus -123.95, -176.77 59.01, 85.18 -98.8, 24.84 279.52, 63.26 -51.76, -30.5 in-in in 8.8003 Saltbr-in 2.7128 HRD-in -77.99, -56.65 70.43, 3.78 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.95, 158.57 APE9-dihe-na 135.16, -154.79 APE8-dihe-in -124.8, 132.89 APE8-rot-in 296.53 APE67-dihe-in -58.95, -25.2 -38.46, -56.52 APE12-dist-in 8.1451 APE11-dist-in 11.4751 APE10-dist-in 5.904 APE9-dist-in 3.5115 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.3 0.155 0.188 A 350.0 336.0 0 25 25 0 [[44, 298]] 1.0 4dh8 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4HPTE P05132 15 351 351.0 ANP:60401 ATPlike Active DFGin 5.7482 14.4242 BLAminus -115.4, 178.03 67.73, 81.09 -92.11, 21.69 273.09, 55.37 -58.71, -29.4 in-in in 9.0532 Saltbr-in 2.6604 HRD-in -90.64, -54.09 71.81, 9.39 in-in-in SNCiii in-in ActLoopNT-in 2.8739 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.27, 162.98 APE9-dihe-na 129.56, -147.32 APE8-dihe-in -127.39, 129.92 APE8-rot-in 299.02 APE67-dihe-in -63.31, -27.9 -40.61, -49.36 APE12-dist-in 8.0686 APE11-dist-in 11.3854 APE10-dist-in 5.8255 APE9-dist-in 3.5734 None TPO198,SEP339 TPO198,SEP339 XRAY 2.15 0.189 0.228 E 350.0 337.0 0 25 25 0 [[44, 298]] 1.0 4hpt Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4HPUE P05132 13 351 351.0 ANP:60402 ATPlike Active DFGin 5.5508 14.4067 BLAminus -117.63, -178.61 63.83, 78.8 -92.22, 24.46 271.46, 55.23 -53.69, -32.94 in-in in 9.0306 Saltbr-in 2.6916 HRD-in -87.73, -52.35 74.85, 8.01 in-in-in SNCiii in-in ActLoopNT-in 2.9145 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.41, 162.17 APE9-dihe-na 134.1, -149.11 APE8-dihe-in -128.69, 136.04 APE8-rot-in 297.56 APE67-dihe-in -58.67, -24.48 -48.3, -49.81 APE12-dist-in 8.0634 APE11-dist-in 11.5067 APE10-dist-in 5.8865 APE9-dist-in 3.4033 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.55 0.173 0.194 E 350.0 339.0 0 25 25 0 [[44, 298]] 1.0 4hpu Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DFXE P05132 2 351 351.0 ANP:60402 ATPlike Active DFGin 5.5242 14.2861 BLAminus -116.71, -179.39 66.13, 78.01 -91.08, 23.34 272.63, 51.46 -56.59, -32.27 in-in in 8.8728 Saltbr-in 2.7287 HRD-in -88.99, -54.58 73.79, 11.03 in-in-in SNCiii in-in ActLoopNT-in 2.9336 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.69, 159.64 APE9-dihe-na 138.16, -148.52 APE8-dihe-in -130.4, 136.32 APE8-rot-in 296.63 APE67-dihe-in -59.91, -24.0 -47.38, -49.37 APE12-dist-in 8.0462 APE11-dist-in 11.4097 APE10-dist-in 5.8188 APE9-dist-in 3.3923 K8C SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.35 0.157 0.179 E 350.0 350.0 0 25 25 0 [[44, 298]] 1.0 4dfx Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4XW4A P05132 15 351 351.0 ANP:60403 ATPlike Active DFGin 5.673 14.5624 BLAminus -117.82, -177.44 65.15, 79.34 -92.69, 26.58 269.45, 57.64 -61.99, -28.36 in-in in 8.9306 Saltbr-in 2.8579 HRD-in -86.05, -50.94 67.2, 15.72 in-in-in SNCiii in-in ActLoopNT-in 3.0139 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.62, 159.69 APE9-dihe-na 135.12, -140.29 APE8-dihe-in -136.84, 125.12 APE8-rot-in 301.75 APE67-dihe-in -61.52, -26.6 -45.5, -44.66 APE12-dist-in 7.961 APE11-dist-in 11.4188 APE10-dist-in 5.9353 APE9-dist-in 3.6644 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.82 0.183 0.24 A 356.0 337.0 0 25 25 0 [[44, 298]] 1.0 4xw4 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 7E0ZA P05132 14 351 351.0 ANP:60401 ATPlike Active DFGin 5.5662 13.8842 BLAminus -118.85, -174.47 59.93, 79.47 -94.43, 25.89 275.59, 63.85 -59.78, -31.6 in-in in 8.6241 Saltbr-in 2.9777 HRD-in -96.8, -56.38 78.26, 13.74 in-in-in SNCiii in-in ActLoopNT-in 2.9292 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.91, 162.74 APE9-dihe-na 131.67, -149.57 APE8-dihe-in -131.04, 130.65 APE8-rot-in 294.41 APE67-dihe-in -63.42, -12.5 -45.48, -52.1 APE12-dist-in 7.8999 APE11-dist-in 11.1823 APE10-dist-in 5.721 APE9-dist-in 3.4 None TPO198,SEP339 TPO198,SEP339 XRAY 2.162 0.184 0.228 A 358.0 337.0 0 25 25 0 [[44, 298]] 1.0 7e0z Mus musculus AGC_PRKACA_MOUSE AGC 1.6e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 7E12A P05132 19 351 351.0 ANP:60401 ATPlike Inactive DFGin 5.3957 14.6175 BLAminus -131.26, -169.7 58.92, 77.12 -93.02, 37.73 266.27, 47.03 -71.49, -23.13 in-in in 8.8067 Saltbr-in 3.2657 HRD-out -127.04, 103.44 -105.61, 37.91 in-in-in SNCiii in-in ActLoopNT-in 2.903 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.78, 159.74 APE9-dihe-na 134.39, -158.49 APE8-dihe-in -118.85, 128.69 APE8-rot-in 308.98 APE67-dihe-in -63.3, -26.53 -50.37, -37.69 APE12-dist-in 8.03 APE11-dist-in 11.3719 APE10-dist-in 5.9651 APE9-dist-in 3.4216 None TPO198,SEP339 TPO198,SEP339 XRAY 2.796 0.208 0.252 A 358.0 333.0 0 25 25 0 [[44, 298]] 1.0 7e12 Mus musculus AGC_PRKACA_MOUSE AGC 1.6e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DG3E P05132 15 351 351.0 ANP:60401 ATPlike Active DFGin 5.4812 14.3421 BLAminus -115.99, -176.62 61.62, 77.98 -90.25, 24.84 270.29, 54.4 -55.44, -35.73 in-in in 8.842 Saltbr-in 2.6947 HRD-in -87.1, -53.93 73.82, 10.76 in-in-in SNCiii in-in ActLoopNT-in 2.8817 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.46, 161.61 APE9-dihe-na 135.41, -150.07 APE8-dihe-in -129.52, 135.22 APE8-rot-in 300.3 APE67-dihe-in -58.11, -23.91 -46.28, -51.67 APE12-dist-in 8.1435 APE11-dist-in 11.4816 APE10-dist-in 5.8864 APE9-dist-in 3.4048 R337A SEP140,TPO198 SEP140,TPO198 XRAY 1.8 0.185 0.217 E 371.0 337.0 0 25 25 0 [[44, 298]] 1.0 4dg3 Mus musculus AGC_PRKACA_MOUSE AGC 1.8e-94 321.8 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3O7LB P05132 18 351 351.0 ANP:60354 ATPlike Inactive DFGin 5.7904 14.6658 BLAminus -108.29, -170.95 57.63, 74.91 -94.92, 22.34 267.93, 64.07 -48.2, -34.6 in-in in 9.0975 Saltbr-in 2.9978 HRD-in -84.13, -53.04 68.25, 25.66 in-in-out SNCiio in-out ActLoopNT-in 2.9497 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -140.78, 178.73 APE9-dihe-na 123.03, -156.78 APE8-dihe-in -134.79, 129.02 APE8-rot-out 131.03 APE67-dihe-in -64.87, -13.33 -37.09, -52.44 APE12-dist-in 8.1152 APE11-dist-in 11.126 APE10-dist-in 5.5927 APE9-dist-in 3.4797 None TPO198 TPO198 XRAY 2.8 0.216 0.287 B 350.0 327.0 3 25 25 0 [[44, 298]] 1.0 3o7l Mus musculus AGC_PRKACA_MOUSE AGC 8.9e-94 319.5 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3FHIA P05132 14 351 351.0 ANP:60400 ATPlike Active DFGin 5.4633 14.263 BLAminus -118.0, -179.45 64.04, 75.7 -86.07, 24.14 267.17, 53.33 -59.82, -32.06 in-in in 8.8874 Saltbr-in 2.7901 HRD-in -94.84, -53.37 68.02, 7.49 in-in-in SNCiii in-in ActLoopNT-in 2.8652 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.67, 136.88 APE9-dihe-na 156.84, -158.52 APE8-dihe-in -126.08, 132.83 APE8-rot-in 296.09 APE67-dihe-in -67.08, -19.88 -42.62, -50.01 APE12-dist-in 8.2333 APE11-dist-in 11.1199 APE10-dist-in 5.402 APE9-dist-in 3.5636 C200A TPO198,SEP339 TPO198,SEP339 XRAY 2.0 0.199 0.226 A 350.0 338.0 0 25 25 0 [[44, 298]] 1.0 3fhi Mus musculus AGC_PRKACA_MOUSE AGC 1e-93 319.3 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC RPS6KA3-1 KS6A3_MOUSE 3G51A P18654 47 346 740.0 ANP:480 ATPlike Inactive DFGin 5.9199 11.0415 None -85.91, -4.29 -148.29, 179.42 -140.68, 33.76 40.5, 80.74 98.88, 16.23 none-none none 999.0 Saltbr-none 999.0 HRD-in -65.38, -43.56 85.71, -58.97 none-out-none SNCnon out-none ActLoopNT-out 10.0751 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 76.27 APE8-rot-in 334.43 APE67-dihe-in -57.95, -24.46 -80.48, -16.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.8 0.216 0.248 A 325.0 280.0 20 28 17 11 [[68, 327], [422, 679]] 2.0 3g51 Mus musculus AGC_RPS6KA3-1_MOUSE AGC 2.6e-97 330.9 1.0 260.0 260.0 210 211 212 214 216 100 118 122 190 192 191 193.0 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
CAMK CAMK2A KCC2A_MOUSE 7B56B P11798 5 307 478.0 ANP:60401 ATPlike Active DFGin 6.7287 14.2318 BLAminus -127.69, 175.68 61.5, 79.97 -89.44, 23.96 289.95, 77.46 -66.33, -24.14 in-in in 8.9633 Saltbr-in 2.7967 HRD-in -75.83, -42.64 71.61, -6.11 in-in-in SNCiii in-in ActLoopNT-in 2.8909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.35, 145.48 APE9-dihe-na 136.45, -166.63 APE8-dihe-in -115.36, 130.21 APE8-rot-in 297.52 APE67-dihe-in -66.37, -13.84 -48.36, -50.63 APE12-dist-in 10.4062 APE11-dist-in 11.6697 APE10-dist-in 5.8831 APE9-dist-in 3.7986 T305A,T306A None None XRAY 1.45 0.191 0.215 B 317.0 303.0 0 28 28 0 [[13, 271]] 1.0 7b56 Mus musculus CAMK_CAMK2A_MOUSE CAMK 1.7e-96 328.6 1.0 256.0 256.0 155 156 157 159 161 42 60 64 132 134 133 135.0 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK MELK MELK_MOUSE 4BFMA Q61846 2 326 643.0 ANP:61000 ATPlike None DFGin 6.7119 14.5698 BLAminus -130.6, -176.06 61.21, 74.64 -103.71, 23.71 285.06, 77.6 -76.76, -13.34 in-in in 8.8474 Saltbr-in 2.9578 HRD-in -75.69, -53.65 79.25, -5.08 in-in-none SNCiin in-none ActLoopNT-in 2.981 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 98.82 APE9-dihe-na 96.69, 172.23 APE8-dihe-in -57.02, 129.84 APE8-rot-in 295.1 APE67-dihe-in -57.11, -19.89 -56.29, -48.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.4427 APE9-dist-in 3.747 T167E None None XRAY 2.35 0.177 0.208 A 334.0 308.0 17 29 17 12 [[11, 263]] 1.0 4bfm Mus musculus CAMK_MELK_MOUSE CAMK 3.3e-88 301.6 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
OTHER POMK SG196_MOUSE 5GZ9A Q3TUA9 54 337 349.0 ANP:1001,MAN:1004 ATPlike,Allosteric Pseudo DFGin 5.2933 13.0229 ABAminus -119.99, -54.35 -93.01, 108.48 -116.58, 23.4 308.09, 4.31 -55.72, -49.95 none-na none 999.0 Saltbr-na 999.0 HRD-out -81.79, 73.24 -60.09, -38.65 na-in-out SNCaio in-out ActLoopNT-in 3.248 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_iioo APE10-dihe-na -60.33, 128.48 APE9-dihe-na -97.57, 144.89 APE8-dihe-in -131.17, 161.49 APE8-rot-na 301.17 APE67-dihe-out -101.62, -18.24 97.94, -172.65 APE12-dist-in 12.5486 APE11-dist-in 13.7295 APE10-dist-out 17.531 APE9-dist-out 9.7434 N66Q,N164Q None None XRAY 2.4 0.234 0.268 A 305.0 280.0 4 31 29 2 [[73, 337]] 1.0 5gz9 Mus musculus OTHER_POMK_MOUSE POMK 1.2e-147 496.2 1.0 265.0 265.0 225 226 227 229 231 107 121 125 200 202 201 203.0 280 256 251 250 249 248 247 246 245 149 Protein O-mannose kinase
STE STK39 STK39_MOUSE 5DBXA Q9Z1W9 65 365 556.0 ANP:401 ATPlike Inactive DFGin 6.8713 15.5873 None -61.74, 151.25 -53.68, 129.38 -99.47, -2.77 72.69, 109.41 -58.5, -56.73 out-out out 16.0249 Saltbr-out 17.4351 HRD-in -69.21, -49.56 75.54, -19.7 out-out-out SNCooo out-out ActLoopNT-out 5.6736 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -90.7, -9.1 APE9-dihe-na -96.35, 164.45 APE8-dihe-in -91.01, 125.18 APE8-rot-in 324.0 APE67-dihe-in -65.76, -19.67 -49.27, -43.15 APE12-dist-none 999.0 APE11-dist-out 25.0408 APE10-dist-out 28.2167 APE9-dist-out 27.3477 T243D None CAS71,CAS128,CAS249,CAS346 XRAY 2.5 0.208 0.246 A 328.0 288.0 13 33 20 13 [[75, 349]] 1.0 5dbx Mus musculus STE_STK39_MOUSE STE 2.3e-90 308.4 1.0 257.0 257.0 221 222 223 225 227 104 121 125 201 203 202 204.0 267 254 249 248 247 246 245 244 243 151 STE20/SPS1-related proline-alanine-rich protein kinase
STE STK39 STK39_MOUSE 5DBXB Q9Z1W9 65 364 556.0 ANP:401 ATPlike Inactive DFGin 6.3307 15.0679 None -67.52, 160.16 -60.64, 125.44 -102.44, -1.98 62.33, 96.08 -52.97, -52.55 out-out out 14.0364 Saltbr-out 13.266 HRD-in -73.49, -48.67 74.98, -19.73 out-out-out SNCooo out-out ActLoopNT-out 5.6752 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -104.19, 109.41 APE9-dihe-na 87.86, -153.92 APE8-dihe-in -128.52, 139.93 APE8-rot-in 317.58 APE67-dihe-in -74.81, -17.12 -52.01, -48.65 APE12-dist-none 999.0 APE11-dist-out 25.567 APE10-dist-out 25.1599 APE9-dist-out 27.7398 T243D None CAS71,CAS128,CAS249,CAS346 XRAY 2.5 0.208 0.246 B 328.0 286.0 14 33 23 10 [[75, 349]] 1.0 5dbx Mus musculus STE_STK39_MOUSE STE 2.3e-90 308.4 1.0 257.0 257.0 221 222 223 225 227 104 121 125 201 203 202 204.0 267 254 249 248 247 246 245 244 243 151 STE20/SPS1-related proline-alanine-rich protein kinase
TKL RIPK3 RIPK3_MOUSE 4M69A Q9QZL0 12 312 486.0 ANP:60401 ATPlike Inactive DFGin 6.3203 13.4024 BLBplus -137.99, 167.73 62.19, 26.69 -80.85, 141.15 41.42, 94.11 79.17, -4.63 out-out out 16.1877 Saltbr-out 16.6938 HRD-in -64.86, -72.1 85.35, 0.02 out-out-out SNCooo out-out ActLoopNT-out 6.4335 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -38.44, -35.37 APE9-dihe-na -67.82, -39.64 APE8-dihe-out -81.63, -25.9 APE8-rot-out 193.07 APE67-dihe-in -56.22, -29.66 -74.57, -26.5 APE12-dist-out 15.2297 APE11-dist-out 16.6409 APE10-dist-out 19.2359 APE9-dist-out 12.3635 None SEP184,TPO231,SEP232 SEP184,TPO231,SEP232 XRAY 2.497 0.222 0.246 A 313.0 287.0 14 34 20 14 [[20, 290]] 1.0 4m69 Mus musculus TKL_RIPK3_MOUSE TKL 7.1e-60 208.7 3.0 265.0 263.0 160 161 162 164 166 51 61 65 140 142 141 143.0 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TYR EPHB2 EPHB2_MOUSE 1JPAA P54763 594 892 986.0 ANP:60400 ATPlike Inactive DFGin 5.7088 15.4887 None -134.81, -163.21 68.34, 57.99 -95.68, 999.0 294.45, 106.32 999.0, 999.0 in-in in 7.779 Saltbr-in 3.0192 HRD-in -67.2, -47.6 76.65, -18.41 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -14.15 APE8-rot-na 35.93 APE67-dihe-in -72.25, 3.83 -49.21, -49.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y596F,Y602F None None XRAY 1.91 0.231 0.27 A 312.0 273.0 26 33 10 23 [[621, 882]] 1.0 1jpa Mus musculus TYR_EPHB2_MOUSE TYR 5.1e-109 369.5 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR EPHB2 EPHB2_MOUSE 1JPAB P54763 594 891 986.0 ANP:60401 ATPlike Inactive DFGin 5.7317 15.6268 None -133.42, -158.93 64.89, 61.18 -100.9, 999.0 292.25, 96.96 999.0, 999.0 in-in in 7.8146 Saltbr-in 2.6861 HRD-in -67.92, -50.57 78.02, -16.62 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -24.77 APE8-rot-na 326.13 APE67-dihe-in -71.91, 4.89 -51.95, -48.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y596F,Y602F None None XRAY 1.91 0.231 0.27 B 312.0 269.0 29 33 10 23 [[621, 882]] 1.0 1jpa Mus musculus TYR_EPHB2_MOUSE TYR 5.1e-109 369.5 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR LYN LYN_MOUSE 2ZV8A P25911 239 501 512.0 ANP:60001 ATPlike Active DFGin 6.2069 14.1657 BLAminus -127.46, 176.54 66.14, 76.26 -98.89, 34.27 306.37, 82.39 -66.23, -26.52 in-in in 8.1816 Saltbr-in 2.8879 HRD-naN -93.92, -49.32 76.02, -10.27 in-in-in SNCiii in-in ActLoopNT-in 2.9539 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -123.91, 116.52 APE9-dihe-in -60.43, 148.58 APE8-dihe-in -80.52, 92.26 APE8-rot-na 28.17 APE67-dihe-in -68.44, -3.54 -43.41, -52.9 APE12-dist-na 9.6338 APE11-dist-na 5.9229 APE10-dist-na 9.7285 APE9-dist-in 5.0044 None None None XRAY 2.7 0.201 0.245 A 279.0 256.0 7 29 22 7 [[247, 499]] 1.0 2zv8 Mus musculus TYR_LYN_MOUSE TYR 4.1e-95 323.9 1.0 260.0 260.0 384 385 386 388 390 275 290 294 364 366 365 367.0 425 413 408 407 406 405 404 403 402 320 Tyrosine-protein kinase Lyn
OTHER PAN3 PAN3_NEUCR 4CZYB Q7SDP4 234 645 656.0 ANP:61650 ATPlike Pseudo DFGin 8.6364 12.9995 None -108.01, 7.82 -124.9, 18.28 -71.16, 143.54 291.41, 999.0 81.95, -4.35 out-na out 13.9696 Saltbr-na 999.0 HRD-in -64.78, -43.28 69.3, -58.59 na-out-na SNCaoa out-na ActLoopNT-out 7.0417 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -68.73, -37.24 APE9-dihe-na -75.95, -42.57 APE8-dihe-na -71.33, -35.43 APE8-rot-na 302.88 APE67-dihe-na -61.0, -48.02 -101.37, 21.03 APE12-dist-na 1.5444 APE11-dist-na 4.8399 APE10-dist-na 5.8244 APE9-dist-na 11.7693 None None None XRAY 3.4 0.223 0.263 B 429.0 403.0 6 15 15 0 [[258, 516]] 1.0 4czy Neurospora crassa OTHER_PAN3_NEUCR PAN3 3.4e-53 189.3 4.0 264.0 261.0 424 425 426 428 430 302 318 322 405 407 406 408.0 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
OTHER PAN3 PAN3_NEUCR 4CZYD Q7SDP4 234 645 656.0 ANP:61650 ATPlike Pseudo DFGin 8.3891 12.6265 None -108.63, 8.9 -122.37, 20.29 -71.82, 141.42 292.67, 999.0 81.18, -5.38 out-na out 13.9082 Saltbr-na 999.0 HRD-in -65.6, -43.11 68.0, -59.39 na-out-na SNCaoa out-na ActLoopNT-out 6.9602 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -69.97, -39.27 APE9-dihe-na -74.97, -41.75 APE8-dihe-na -69.88, -35.71 APE8-rot-na 304.18 APE67-dihe-na -59.83, -48.03 -102.6, 21.19 APE12-dist-na 1.5346 APE11-dist-na 4.8332 APE10-dist-na 5.6883 APE9-dist-na 12.0116 None None None XRAY 3.4 0.223 0.263 D 429.0 403.0 6 15 15 0 [[258, 516]] 1.0 4czy Neurospora crassa OTHER_PAN3_NEUCR PAN3 3.4e-53 189.3 4.0 264.0 261.0 424 425 426 428 430 302 318 322 405 407 406 408.0 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
STE MAP2K1 MP2K1_RABIT 7JUWC P29678 40 382 393.0 ANP:401 ATPlike Inactive DFGin 5.4761 13.4814 BLBplus -119.08, 163.59 62.65, 35.07 -73.68, 154.5 52.17, 104.28 -73.77, 81.69 out-out out 15.4699 Saltbr-out 15.9777 HRD-in -78.46, -50.39 75.67, -1.62 out-out-out SNCooo out-out ActLoopNT-out 9.0937 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -134.09, 125.81 APE9-dihe-na -89.61, -160.68 APE8-dihe-out -92.22, -18.15 APE8-rot-out 194.93 APE67-dihe-out -134.04, 131.23 -117.23, 164.93 APE12-dist-out 17.3483 APE11-dist-out 16.6141 APE10-dist-out 20.5819 APE9-dist-out 12.6092 None None None XRAY 2.88 0.245 0.286 C 384.0 311.0 32 26 26 0 [[68, 361]] 1.0 7juw Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JURC P29678 41 381 393.0 ANP:401,QOM:402 ATPlike,Type1 Inactive DFGin 6.613 14.002 BLBplus -156.22, 177.66 63.23, 45.15 -109.91, 167.01 49.79, 96.28 -84.59, 94.82 out-out out 15.2731 Saltbr-out 15.8781 HRD-in -66.44, -49.39 76.73, -8.84 out-out-out SNCooo out-out ActLoopNT-out 9.5088 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -118.97, 111.39 APE9-dihe-na -105.66, -145.56 APE8-dihe-out -103.38, -4.62 APE8-rot-out 47.7 APE67-dihe-out -108.36, 139.88 -114.51, 107.19 APE12-dist-out 17.0478 APE11-dist-out 19.9859 APE10-dist-out 22.0123 APE9-dist-out 15.1448 None None None XRAY 2.82 0.237 0.277 C 384.0 304.0 37 26 26 0 [[68, 361]] 1.0 7jur Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JUTC P29678 41 380 393.0 ANP:401,3EW:402 ATPlike,Type3 Inactive DFGin 6.0671 13.9401 BLBplus -133.84, -178.36 52.69, 31.27 -86.2, 157.2 55.82, 93.16 -83.8, 97.49 out-out out 15.809 Saltbr-out 15.0751 HRD-in -69.63, -49.75 78.05, -10.01 out-out-out SNCooo out-out ActLoopNT-out 9.5518 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -106.95, 117.74 APE9-dihe-na -110.82, -149.07 APE8-dihe-out -94.42, -11.28 APE8-rot-out 36.3 APE67-dihe-out -120.05, 132.49 -111.03, 116.45 APE12-dist-out 17.2399 APE11-dist-out 19.8243 APE10-dist-out 21.7513 APE9-dist-out 14.8236 None None None XRAY 3.09 0.259 0.3 C 384.0 303.0 37 26 26 0 [[68, 361]] 1.0 7jut Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JUUC P29678 43 381 393.0 ANP:401,4BM:402 ATPlike,Type3 Inactive DFGin 6.5736 14.0084 BLBplus -143.65, 177.32 57.69, 37.46 -92.33, 152.26 41.94, 94.89 -75.77, 92.54 out-out out 15.833 Saltbr-out 14.7395 HRD-in -70.37, -49.34 74.88, -6.99 out-out-out SNCooo out-out ActLoopNT-out 9.3359 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -102.48, 121.01 APE9-dihe-na -118.18, -151.72 APE8-dihe-out -92.91, -15.39 APE8-rot-out 41.03 APE67-dihe-out -126.24, 128.64 -103.62, 122.66 APE12-dist-out 16.8116 APE11-dist-out 19.5747 APE10-dist-out 21.4997 APE9-dist-out 14.8147 None None None XRAY 3.19 0.242 0.258 C 384.0 302.0 37 26 26 0 [[68, 361]] 1.0 7juu Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JUVC P29678 41 381 393.0 ANP:401,VKG:402 ATPlike,Type3 Inactive DFGin 6.2421 14.0185 BLBplus -157.56, 157.79 64.55, 38.6 -93.84, 164.37 42.83, 100.3 -83.58, 81.75 out-out out 16.0313 Saltbr-out 15.4096 HRD-in -64.23, -51.09 77.84, -3.99 out-out-out SNCooo out-out ActLoopNT-out 9.291 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -121.06, 123.07 APE9-dihe-na -111.51, -147.21 APE8-dihe-out -99.25, -5.79 APE8-rot-out 47.73 APE67-dihe-out -106.23, 137.61 -113.69, 113.69 APE12-dist-out 16.9686 APE11-dist-out 20.03 APE10-dist-out 21.6139 APE9-dist-out 15.1297 None None None XRAY 3.36 0.242 0.255 C 384.0 304.0 37 26 26 0 [[68, 361]] 1.0 7juv Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JUXC P29678 40 381 393.0 ANP:401,QOM:402 ATPlike,Type3 Inactive DFGin 6.4278 14.3556 BLBplus -129.48, -171.66 44.07, 32.82 -84.98, 164.12 41.6, 98.75 -82.14, 71.95 out-out out 17.5863 Saltbr-out 20.1916 HRD-in -72.38, -56.06 82.77, -10.45 out-out-out SNCooo out-out ActLoopNT-out 9.1972 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -105.79, 149.07 APE9-dihe-na -128.12, -140.49 APE8-dihe-out -102.97, -28.75 APE8-rot-out 180.26 APE67-dihe-out -123.35, 132.01 -101.05, 135.7 APE12-dist-out 15.9606 APE11-dist-out 18.6447 APE10-dist-out 21.1274 APE9-dist-out 13.9765 None None None XRAY 3.34 0.265 0.283 C 384.0 308.0 34 26 26 0 [[68, 361]] 1.0 7jux Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JUYC P29678 40 382 393.0 ANP:401,EUI:402 ATPlike,Type3 Inactive DFGin 5.8023 13.9446 BLBplus -119.74, 162.94 62.38, 34.15 -75.02, 153.8 53.17, 104.23 -74.72, 81.57 out-out out 15.6895 Saltbr-out 15.7759 HRD-in -78.99, -50.85 75.95, -2.2 out-out-out SNCooo out-out ActLoopNT-out 8.6396 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -134.38, 125.81 APE9-dihe-na -89.68, -160.4 APE8-dihe-out -91.9, -17.82 APE8-rot-out 194.83 APE67-dihe-out -134.16, 130.72 -117.22, 165.02 APE12-dist-out 17.5274 APE11-dist-out 16.8292 APE10-dist-out 20.535 APE9-dist-out 12.5725 None None None XRAY 3.096 0.248 0.257 C 384.0 311.0 32 26 26 0 [[68, 361]] 1.0 7juy Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JUZC P29678 40 382 393.0 ANP:401,3EW:402 ATPlike,Type3 Inactive DFGin 5.9412 14.2448 BLBplus -127.35, 173.99 64.59, 36.11 -89.55, 153.11 55.39, 95.23 -79.11, 95.72 out-out out 16.8967 Saltbr-out 15.3901 HRD-in -78.66, -56.19 75.89, -1.31 out-out-out SNCooo out-out ActLoopNT-out 8.8285 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -140.68, 119.69 APE9-dihe-na -83.26, -173.5 APE8-dihe-out -76.47, -20.99 APE8-rot-out 195.18 APE67-dihe-out -133.01, 129.38 -114.64, 162.26 APE12-dist-out 17.257 APE11-dist-out 16.6053 APE10-dist-out 20.4548 APE9-dist-out 12.4227 None None None XRAY 3.21 0.255 0.272 C 384.0 308.0 35 26 26 0 [[68, 361]] 1.0 7juz Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JV0C P29678 40 382 393.0 ANP:401,4BM:402 ATPlike,Type3 Inactive DFGin 5.8727 14.2702 BLBplus -118.46, 167.04 65.91, 31.94 -77.55, 158.19 54.28, 101.68 -82.73, 82.06 out-out out 16.4454 Saltbr-out 16.8702 HRD-in -78.95, -48.37 72.45, 0.0 out-out-out SNCooo out-out ActLoopNT-out 8.9767 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -134.69, 127.82 APE9-dihe-na -92.23, -161.01 APE8-dihe-out -91.79, -17.2 APE8-rot-out 194.87 APE67-dihe-out -131.33, 129.9 -118.91, 161.4 APE12-dist-out 17.5672 APE11-dist-out 16.9191 APE10-dist-out 20.7981 APE9-dist-out 12.6788 None None None XRAY 3.63 0.247 0.26 C 384.0 308.0 35 26 26 0 [[68, 361]] 1.0 7jv0 Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JV1C P29678 40 381 393.0 ANP:401,VKG:402 ATPlike,Type3 Inactive DFGin 6.4027 13.987 BLBplus -129.45, -171.63 44.64, 33.58 -84.88, 163.88 41.4, 98.6 -82.69, 72.31 out-out out 17.7833 Saltbr-out 17.8868 HRD-in -72.64, -55.74 83.07, -10.49 out-out-out SNCooo out-out ActLoopNT-out 9.5186 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -106.03, 153.74 APE9-dihe-na -129.76, -140.43 APE8-dihe-out -102.55, -29.44 APE8-rot-out 180.23 APE67-dihe-out -122.99, 132.28 -101.94, 135.93 APE12-dist-out 15.759 APE11-dist-out 19.0444 APE10-dist-out 21.0399 APE9-dist-out 14.1526 None None None XRAY 3.62 0.278 0.303 C 384.0 308.0 34 26 26 0 [[68, 361]] 1.0 7jv1 Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JUSC P29678 41 381 393.0 VKD:501,ANP:502 Type3,ATPlike Inactive DFGin 6.6408 14.136 BLBplus -157.57, 158.09 64.1, 38.39 -94.54, 165.57 43.42, 100.58 -82.33, 83.96 out-out out 16.4432 Saltbr-out 17.0647 HRD-in -64.72, -50.01 79.43, -5.86 out-out-out SNCooo out-out ActLoopNT-out 9.2055 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -121.8, 123.06 APE9-dihe-na -111.39, -149.55 APE8-dihe-out -101.45, -2.19 APE8-rot-out 46.64 APE67-dihe-out -107.18, 138.05 -110.5, 111.25 APE12-dist-out 16.9565 APE11-dist-out 19.7412 APE10-dist-out 21.5845 APE9-dist-out 15.1016 None None None XRAY 2.99 0.249 0.265 C 384.0 304.0 37 26 26 0 [[68, 361]] 1.0 7jus Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
OTHER PINK1 PINK1_PEDHC 8UYHA E0W1I1 115 574 575.0 ANP:601 ATPlike Active DFGin 9.3218 14.8193 BLAminus -130.08, -169.42 57.7, 62.71 -86.71, 26.39 286.61, 80.23 -66.61, -35.48 in-in in 7.9669 Saltbr-in 3.2696 HRD-in -73.02, -43.12 61.9, 7.28 in-in-in SNCiii in-in ActLoopNT-in 2.7639 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na 161.16, -131.74 APE9-dihe-na -112.83, -108.55 APE8-dihe-in -69.42, 145.98 APE8-rot-na 76.98 APE67-dihe-in -73.97, -39.08 -95.26, -9.75 APE12-dist-in 8.0481 APE11-dist-in 10.2621 APE10-dist-in 5.8343 APE9-dist-in 3.5719 None TPO305 TPO305 EM 2.84 999.0 999.0 A 463.0 375.0 49 34 34 0 [[64, 514]] 1.0 8uyh Pediculus humanus OTHER_PINK1_PEDHC PINK1 1e-86 297.1 4.0 367.0 364.0 356 357 358 360 362 193 214 218 331 333 332 334.0 408 390 385 384 383 382 381 380 379 291 Serine/threonine-protein kinase Pink1, mitochondrial
OTHER PINK1 PINK1_PEDHC 8UYHB E0W1I1 121 574 575.0 ANP:601 ATPlike Active DFGin 9.4492 14.8706 BLAminus -129.89, -169.12 59.53, 64.83 -87.85, 20.05 283.99, 82.98 -70.23, -23.56 in-in in 7.8465 Saltbr-in 2.3873 HRD-in -70.23, -41.92 63.21, 0.58 in-in-in SNCiii in-in ActLoopNT-in 2.9317 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na 144.56, -157.47 APE9-dihe-na -105.64, -99.0 APE8-dihe-in -70.54, 139.11 APE8-rot-na 52.17 APE67-dihe-in -71.03, -46.42 -78.22, -15.68 APE12-dist-in 7.74 APE11-dist-in 10.3854 APE10-dist-in 6.127 APE9-dist-in 3.7808 None TPO305 TPO305 EM 2.84 999.0 999.0 B 463.0 370.0 50 34 34 0 [[64, 514]] 1.0 8uyh Pediculus humanus OTHER_PINK1_PEDHC PINK1 1e-86 297.1 4.0 367.0 364.0 356 357 358 360 362 193 214 218 331 333 332 334.0 408 390 385 384 383 382 381 380 379 291 Serine/threonine-protein kinase Pink1, mitochondrial
CAMK CDPK1 CDPK1_PLABA 3Q5IA A0A509AHB6 38 518 523.0 ANP:61634 ATPlike Active DFGin 6.7672 14.4658 BLAminus -128.23, -176.48 60.5, 79.46 -95.96, 19.56 285.65, 75.94 -57.69, -30.19 in-in in 9.2369 Saltbr-in 3.1236 HRD-in -79.9, -50.9 74.57, -2.92 in-in-in SNCiii in-in ActLoopNT-in 2.9879 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.44, 148.94 APE9-dihe-na 143.23, -165.03 APE8-dihe-in -126.86, 133.51 APE8-rot-in 304.61 APE67-dihe-in -56.9, -32.89 -45.51, -52.84 APE12-dist-in 8.5894 APE11-dist-in 11.4649 APE10-dist-in 5.6669 APE9-dist-in 3.6336 None None None XRAY 2.1 0.197 0.25 A 504.0 461.0 18 27 27 0 [[57, 324]] 1.0 3q5i Plasmodium berghei CAMK_CDPK1_PLABA CAMK 4e-85 291.5 4.0 256.0 253.0 210 211 212 214 216 86 115 119 187 189 188 190.0 248 237 232 231 230 229 228 227 226 145 Calcium-dependent protein kinase 1
CMGC MAPK Q7KQK7_PLAF7 3NIEA Q7KQK7 95 499 508.0 ANP:60430 ATPlike Inactive DFGin 6.659 15.7756 BLAminus -144.93, -172.32 65.91, 51.77 -86.61, 14.68 283.07, 77.79 -60.63, -18.53 in-in in 8.8674 Saltbr-in 2.5027 HRD-in -68.06, -47.27 80.58, -8.2 in-in-out SNCiio in-out ActLoopNT-in 2.8564 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -70.3, 124.83 APE9-dihe-na -125.0, 112.94 APE8-dihe-in -93.96, 116.45 APE8-rot-in 298.12 APE67-dihe-in -72.32, -16.48 -104.15, 8.37 APE12-dist-out 16.933 APE11-dist-in 12.6333 APE10-dist-out 15.2444 APE9-dist-out 11.2001 None None None XRAY 2.3 0.225 0.268 A 429.0 364.0 41 53 22 31 [[106, 446]] 1.0 3nie Plasmodium falciparum CMGC_MAPK_PLAF7 CMGC 8.1e-36 228.5 1.0 161.0 305.0 249 250 251 253 255 135 153 157 229 231 230 232.0 315 302 297 296 295 294 293 292 291 188 Mitogen-activated protein kinase
CMGC MAPK Q7KQK7_PLAF7 3NIEB Q7KQK7 95 505 508.0 ANP:60430 ATPlike Inactive DFGin 6.2209 15.3557 BLAminus -134.35, -174.02 73.7, 49.83 -83.77, 18.2 290.52, 87.11 -64.56, -24.17 in-in in 8.7675 Saltbr-in 2.6099 HRD-in -70.6, -44.59 78.38, -12.33 in-in-out SNCiio in-out ActLoopNT-in 2.654 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -62.89, 130.52 APE9-dihe-na -133.69, 126.34 APE8-dihe-in -95.72, 114.26 APE8-rot-in 300.21 APE67-dihe-in -71.21, -11.01 -104.83, 7.14 APE12-dist-out 17.1903 APE11-dist-in 12.7805 APE10-dist-out 15.2581 APE9-dist-out 11.2183 None None None XRAY 2.3 0.225 0.268 B 429.0 367.0 44 53 21 32 [[106, 446]] 1.0 3nie Plasmodium falciparum CMGC_MAPK_PLAF7 CMGC 8.1e-36 228.5 1.0 161.0 305.0 249 250 251 253 255 135 153 157 229 231 230 232.0 315 302 297 296 295 294 293 292 291 188 Mitogen-activated protein kinase
CMGC PSTK1 Q8IL19_PLAF7 3LLTA Q8IL19 535 875 881.0 ANP:877 ATPlike Active DFGin 7.1427 15.2163 BLAminus -123.92, -179.42 67.73, 65.46 -96.96, 21.34 280.85, 86.26 -60.95, -43.39 in-in in 9.0128 Saltbr-in 2.6211 HRD-in -67.76, -41.54 71.0, -10.38 in-in-in SNCiii in-in ActLoopNT-in 2.8536 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.91, 173.39 APE9-dihe-na 75.57, 154.71 APE8-dihe-in -70.15, 136.15 APE8-rot-in 300.24 APE67-dihe-in -71.32, -17.13 -39.04, -49.24 APE12-dist-in 13.2051 APE11-dist-in 11.3898 APE10-dist-in 7.5138 APE9-dist-in 2.9414 None None None XRAY 2.5 0.225 0.267 A 360.0 341.0 0 25 25 0 [[552, 874]] 1.0 3llt Plasmodium falciparum CMGC_PSTK1_PLAF7 CMGC 8.3e-71 244.6 2.0 301.0 300.0 719 720 721 723 725 581 596 600 674 676 675 677.0 756 744 739 738 737 736 735 734 733 631 Protein serine/threonine kinase-1
OTHER PK7 O96214_PLAFA 2PMLX O96214 1 316 320.0 ANP:60381 ATPlike Inactive DFGin 7.27 13.6658 BLAminus -145.98, -179.86 51.66, 93.56 -100.75, 34.63 303.23, 91.32 -71.84, -18.04 out-out out 10.1568 Saltbr-out 3.6908 HRD-in -69.85, -44.18 75.61, 1.42 out-in-in SNCoii in-in ActLoopNT-in 2.9421 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -171.9, 141.96 APE9-dihe-na 131.5, -150.95 APE8-dihe-in -107.69, 124.02 APE8-rot-in 304.33 APE67-dihe-in -76.82, -4.32 -47.17, -48.3 APE12-dist-in 11.2869 APE11-dist-in 11.8028 APE10-dist-in 6.3729 APE9-dist-in 3.6802 None None None XRAY 2.6 0.261 0.327 X 348.0 308.0 8 26 26 0 [[28, 319]] 1.0 2pml Plasmodium falciparum OTHER_PK7_PLAFA CAMK 9.9e-37 136.1 1.0 256.0 256.0 189 190 191 193 195 55 88 92 169 171 170 172.0 229 215 210 209 208 207 206 205 204 118 mitogen-activated protein kinase kinase
AGC PKG KGP_PLAVS 5DZCA A5K0N4 1 843 846.0 ANP:61001 ATPlike Inactive DFGin 6.296 14.6954 BLAminus -123.96, 179.25 60.5, 83.72 -97.75, 30.63 287.02, 82.05 -66.77, -34.57 out-out out 10.7499 Saltbr-out 4.7307 HRD-in -75.23, -49.58 78.17, -9.81 out-in-in SNCoii in-in ActLoopNT-in 2.9921 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.27, 147.09 APE9-dihe-na 122.94, -168.21 APE8-dihe-in -102.7, 120.96 APE8-rot-in 294.87 APE67-dihe-in -65.78, -22.03 -47.03, -45.8 APE12-dist-in 9.4444 APE11-dist-in 11.26 APE10-dist-in 5.3904 APE9-dist-in 3.6504 None None None XRAY 2.3 0.223 0.255 A 847.0 815.0 0 25 25 0 [[534, 791]] 1.0 5dzc Plasmodium vivax AGC_PKG_PLAVS AGC 1.3e-75 260.5 3.0 260.0 258.0 674 675 676 678 680 563 582 586 654 656 655 657.0 711 699 694 693 692 691 690 689 688 612 cGMP-dependent protein kinase
AGC PRKCB KPCB_RAT 3PFQA P68403 101 668 671.0 ANP:60800 ATPlike Inactive DFGin 6.062 13.3175 BLAminus -127.91, -175.53 60.89, 88.17 -109.45, 18.93 297.91, 72.76 -66.81, 8.41 in-out in 9.3193 Saltbr-out 4.5108 HRD-out -53.59, -66.06 65.15, 50.69 out-in-in SNCoii in-in ActLoopNT-in 3.087 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.97, -178.34 APE9-dihe-na 109.42, -153.48 APE8-dihe-in -112.52, 141.29 APE8-rot-in 328.3 APE67-dihe-in -90.42, -60.35 -50.4, -26.29 APE12-dist-in 8.8919 APE11-dist-in 11.9645 APE10-dist-in 6.3533 APE9-dist-in 4.0339 C71S,C217S,R622S TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 4.0 0.244 0.244 A 674.0 521.0 0 28 28 0 [[342, 600]] 1.0 3pfq Rattus norvegicus AGC_PRKCB_RAT AGC 1.5e-97 332.1 1.0 260.0 260.0 483 484 485 487 489 371 390 394 463 465 464 466.0 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
CMGC MAPK1 MK01_RAT 4S33A P63086 4 355 358.0 ANP:401 ATPlike Inactive DFGin 6.7431 16.086 BLAminus -130.86, 178.79 71.13, 76.62 -98.92, 24.03 286.96, 71.68 -62.72, -21.16 in-in in 9.6873 Saltbr-in 2.6802 HRD-in -72.9, -49.96 78.15, -0.96 in-in-out SNCiio in-out ActLoopNT-in 2.8648 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -104.41, -43.84 APE9-dihe-na -64.59, 164.35 APE8-dihe-in -56.21, 123.2 APE8-rot-in 315.9 APE67-dihe-in -61.37, -21.31 -48.55, -49.93 APE12-dist-out 14.7318 APE11-dist-in 11.3056 APE10-dist-in 7.3108 APE9-dist-in 4.4832 R65S None None XRAY 1.48 0.199 0.239 A 358.0 347.0 0 31 31 0 [[23, 311]] 1.0 4s33 Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.5e-85 293.0 1.0 301.0 301.0 164 165 166 168 170 52 69 73 144 146 145 147.0 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 4S32A P63086 4 354 358.0 ANP:401 ATPlike Inactive DFGin 6.6461 16.3353 BLAminus -133.92, 176.75 65.37, 79.23 -97.7, 23.57 287.97, 74.34 -66.64, -19.31 in-out in 9.8686 Saltbr-out 3.654 HRD-in -75.76, -45.6 71.68, 4.61 out-in-out SNCoio in-out ActLoopNT-in 2.8278 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -98.88, -32.08 APE9-dihe-na -65.5, 159.94 APE8-dihe-in -53.88, 129.7 APE8-rot-in 310.08 APE67-dihe-in -61.98, -20.6 -58.72, -45.65 APE12-dist-out 14.5455 APE11-dist-in 11.219 APE10-dist-in 7.4905 APE9-dist-in 4.4333 None None None XRAY 1.34 0.199 0.231 A 358.0 346.0 0 31 31 0 [[23, 311]] 1.0 4s32 Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.3e-85 293.2 1.0 301.0 301.0 164 165 166 168 170 52 69 73 144 146 145 147.0 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 7UGBA P63086 9 354 358.0 ANP:60401 ATPlike Inactive DFGin 6.8438 15.6136 BLAminus -132.85, -175.34 66.19, 68.8 -95.15, 22.62 283.13, 71.04 -65.04, -17.4 in-in in 9.2984 Saltbr-in 3.0947 HRD-in -74.44, -45.95 75.99, -7.39 in-in-out SNCiio in-out ActLoopNT-in 2.7599 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -141.06, 152.87 APE9-dihe-na -67.4, -32.8 APE8-dihe-in -151.29, 138.48 APE8-rot-out 186.29 APE67-dihe-in -67.11, -12.06 -109.33, 7.55 APE12-dist-in 8.5189 APE11-dist-in 12.1904 APE10-dist-out 9.145 APE9-dist-out 11.3673 None None None XRAY 1.9 0.181 0.228 A 380.0 333.0 9 31 22 9 [[23, 311]] 1.0 7ugb Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.6e-85 292.9 1.0 301.0 301.0 164 165 166 168 170 52 69 73 144 146 145 147.0 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 4S34A P63086 4 354 358.0 ANP:402 ATPlike Inactive DFGin 6.9305 15.9209 BLAminus -141.95, 172.44 70.56, 81.84 -99.71, 28.41 294.26, 76.1 -60.19, -38.53 in-out in 9.8624 Saltbr-out 3.6484 HRD-in -79.44, -51.86 83.9, -4.35 out-in-out SNCoio in-out ActLoopNT-in 2.8808 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -91.12, -42.94 APE9-dihe-na -58.97, 168.13 APE8-dihe-in -69.02, 123.37 APE8-rot-in 313.04 APE67-dihe-in -67.86, -24.53 -49.65, -45.75 APE12-dist-out 14.8428 APE11-dist-in 11.3273 APE10-dist-in 7.2767 APE9-dist-in 4.4811 I84A None None XRAY 2.5 0.182 0.255 A 358.0 343.0 0 31 31 0 [[23, 311]] 1.0 4s34 Rattus norvegicus CMGC_MAPK1_RAT CMGC 2.9e-85 292.1 1.0 301.0 301.0 164 165 166 168 170 52 69 73 144 146 145 147.0 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 8RQVA P63086 4 354 358.0 ANP:501 ATPlike Inactive DFGin 6.9036 16.0694 BLAminus -129.6, -175.7 63.15, 70.39 -89.62, 28.98 289.85, 76.4 -67.34, -38.13 in-out in 9.7114 Saltbr-out 4.2746 HRD-in -67.81, -55.04 72.76, 2.89 out-in-out SNCoio in-out ActLoopNT-in 2.7655 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oiii APE10-dihe-na -100.88, -30.73 APE9-dihe-na -77.54, 159.87 APE8-dihe-in -50.38, 124.93 APE8-rot-none 999.0 APE67-dihe-in -63.77, -19.96 -54.06, -49.39 APE12-dist-out 14.154 APE11-dist-in 10.7528 APE10-dist-in 7.0254 APE9-dist-in 4.3496 T188A None None XRAY 2.19 0.22 0.268 A 365.0 346.0 0 31 31 0 [[23, 311]] 1.0 8rqv Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.1e-84 290.1 1.0 301.0 301.0 164 165 166 168 170 52 69 73 144 146 145 147.0 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 8RQXA P63086 4 353 358.0 ANP:501 ATPlike Inactive DFGin 6.7525 15.7711 BLAminus -131.54, -179.98 70.52, 77.44 -96.49, 23.47 286.75, 76.4 -63.49, -27.29 in-out in 9.2826 Saltbr-out 4.0303 HRD-in -71.44, -55.38 74.63, 0.71 out-in-out SNCoio in-out ActLoopNT-in 2.8623 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oiii APE10-dihe-na -102.41, -41.91 APE9-dihe-na -63.48, 155.78 APE8-dihe-in -53.17, 123.33 APE8-rot-na 196.55 APE67-dihe-in -71.02, -16.45 -50.75, -40.77 APE12-dist-out 14.2124 APE11-dist-in 10.7678 APE10-dist-in 6.9866 APE9-dist-in 4.4522 R65S,T188D None None XRAY 1.7 0.199 0.231 A 365.0 344.0 0 31 31 0 [[23, 311]] 1.0 8rqx Rattus norvegicus CMGC_MAPK1_RAT CMGC 3.4e-84 288.6 1.0 301.0 301.0 164 165 166 168 170 52 69 73 144 146 145 147.0 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 8RQWA P63086 4 354 358.0 ANP:501 ATPlike Inactive DFGin 6.8494 16.0159 BLAminus -129.63, 178.83 67.86, 79.37 -97.6, 20.5 285.29, 78.65 -60.41, -30.78 in-out in 9.7711 Saltbr-out 4.0654 HRD-in -69.59, -52.69 70.29, 6.23 out-in-out SNCoio in-out ActLoopNT-in 2.8367 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oiii APE10-dihe-na -111.03, -43.37 APE9-dihe-na -66.74, 156.04 APE8-dihe-in -59.11, 129.69 APE8-rot-na 165.64 APE67-dihe-in -63.23, -21.3 -54.35, -46.88 APE12-dist-out 14.6367 APE11-dist-in 10.9228 APE10-dist-in 6.9125 APE9-dist-in 4.2589 T188E None None XRAY 1.8 0.198 0.231 A 365.0 344.0 0 31 31 0 [[23, 311]] 1.0 8rqw Rattus norvegicus CMGC_MAPK1_RAT CMGC 3e-84 288.8 1.0 301.0 301.0 164 165 166 168 170 52 69 73 144 146 145 147.0 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
OTHER WNK1 WNK1_RAT 5W7TA Q9JIH7 210 482 2126.0 ANP:60501 ATPlike Inactive DFGin 6.4172 15.9348 BLBtrans -104.69, 171.72 66.72, 19.42 -58.26, 129.69 184.83, 52.8 82.8, 3.34 out-na out 14.5394 Saltbr-na 999.0 HRD-in -71.27, -50.06 75.36, -9.98 na-out-out SNCaoo out-out ActLoopNT-out 8.5837 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -87.54, -6.4 APE9-dihe-na 140.44, -174.25 APE8-dihe-in -100.52, 116.85 APE8-rot-in 301.69 APE67-dihe-in -56.05, -31.73 -45.94, -43.4 APE12-dist-out 14.8779 APE11-dist-in 11.5748 APE10-dist-out 12.3081 APE9-dist-in 5.4212 None SEP382 SEP382 XRAY 2.01 0.175 0.227 A 277.0 273.0 0 26 26 0 [[220, 479]] 1.0 5w7t Rattus norvegicus OTHER_WNK1_RAT WNK 1.7e-180 603.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_RAT 5W7TB Q9JIH7 210 482 2126.0 ANP:60501 ATPlike Inactive DFGin 6.3857 15.245 BLBtrans -103.97, 173.91 64.08, 22.88 -61.0, 131.49 184.03, 62.56 90.07, -15.7 out-na out 14.1288 Saltbr-na 999.0 HRD-in -70.75, -51.57 74.83, -5.85 na-out-out SNCaoo out-out ActLoopNT-out 7.222 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -112.88, 5.47 APE9-dihe-na -140.59, -178.52 APE8-dihe-in -108.13, 115.32 APE8-rot-in 305.01 APE67-dihe-in -55.56, -28.14 -49.44, -36.46 APE12-dist-out 14.7107 APE11-dist-in 12.593 APE10-dist-in 7.8096 APE9-dist-in 4.793 None SEP382 SEP382 XRAY 2.01 0.175 0.227 B 277.0 273.0 0 26 26 0 [[220, 479]] 1.0 5w7t Rattus norvegicus OTHER_WNK1_RAT WNK 1.7e-180 603.7 1.0 260.0 260.0 367 368 369 371 373 250 268 272 346 348 347 349.0 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
AGC CBK1 CBK1_YEAST 4LQSA P53894 294 749 756.0 ANP:801 ATPlike Inactive None 999.0 16.2025 None 53.14, -148.73 -160.92, 157.71 -53.16, -18.83 35.56, 134.57 105.29, -25.04 none-none none 999.0 Saltbr-none 999.0 HRD-in -66.84, -59.33 53.37, 19.81 none-out-out SNCnoo out-out ActLoopNT-out 11.5265 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na 51.76, -143.69 APE9-dihe-na -76.97, 123.71 APE8-dihe-in -85.35, 159.33 APE8-rot-out 194.03 APE67-dihe-out -98.15, -1.82 -67.37, 76.79 APE12-dist-out 18.6277 APE11-dist-out 18.6511 APE10-dist-out 15.2408 APE9-dist-out 9.9075 D475A None None XRAY 3.3 0.272 0.307 A 508.0 372.0 59 89 45 44 [[352, 672]] 1.0 4lqs Saccharomyces cerevisiae AGC_CBK1_YEAST AGC 8.9e-95 322.8 1.0 260.0 260.0 492 493 494 496 498 381 400 404 472 474 473 475.0 593 581 576 575 574 573 572 571 570 430 Serine/threonine-protein kinase CBK1
AGC CBK1 CBK1_YEAST 5NCLA P53894 266 756 756.0 ANP:801 ATPlike Inactive None 999.0 14.7679 None -124.95, -0.24 -167.04, -169.57 -142.87, 6.12 315.3, 73.05 87.79, 14.17 none-none none 999.0 Saltbr-none 999.0 HRD-in -82.26, -37.95 50.09, 24.61 none-out-out SNCnoo out-out ActLoopNT-out 10.0838 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -121.55, -26.93 APE9-dihe-na 94.26, 55.75 APE8-dihe-in -40.67, 138.08 APE8-rot-out 180.68 APE67-dihe-out -56.77, 157.77 -73.6, -6.03 APE12-dist-out 20.6313 APE11-dist-out 16.5018 APE10-dist-out 17.631 APE9-dist-out 9.2099 D475A None None XRAY 3.15 0.237 0.298 A 508.0 418.0 51 89 53 36 [[352, 672]] 1.0 5ncl Saccharomyces cerevisiae AGC_CBK1_YEAST AGC 8.9e-95 322.8 1.0 260.0 260.0 492 493 494 496 498 381 400 404 472 474 473 475.0 593 581 576 575 574 573 572 571 570 430 Serine/threonine-protein kinase CBK1
AGC CBK1 CBK1_YEAST 4LQPA P53894 282 749 756.0 ANP:801 ATPlike Inactive None 11.3491 17.1416 None 51.11, -136.69 -160.15, 166.75 -53.4, -31.02 62.24, 131.47 101.1, -24.98 none-none none 999.0 Saltbr-none 999.0 HRD-in -48.74, -51.29 56.68, 17.66 none-out-out SNCnoo out-out ActLoopNT-out 12.1073 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na 57.38, -156.31 APE9-dihe-na -77.68, 150.18 APE8-dihe-in -91.6, 155.34 APE8-rot-out 192.52 APE67-dihe-out -54.18, -52.1 -73.01, 58.69 APE12-dist-out 19.6278 APE11-dist-out 18.0811 APE10-dist-out 14.8874 APE9-dist-out 10.6047 D475A,T743E None None XRAY 4.5 0.289 0.31 A 508.0 383.0 61 89 40 49 [[352, 672]] 1.0 4lqp Saccharomyces cerevisiae AGC_CBK1_YEAST AGC 8.9e-95 322.8 1.0 260.0 260.0 492 493 494 496 498 381 400 404 472 474 473 475.0 593 581 576 575 574 573 572 571 570 430 Serine/threonine-protein kinase CBK1
AGC CBK1 CBK1_YEAST 4LQQA P53894 282 749 756.0 ANP:801 ATPlike Inactive None 999.0 15.547 None 58.85, -148.63 -164.28, 166.54 -77.58, -28.26 39.76, 84.0 103.41, -23.9 none-none none 999.0 Saltbr-none 999.0 HRD-in -81.04, -47.82 56.38, 16.19 none-out-out SNCnoo out-out ActLoopNT-out 12.3427 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na 56.18, -157.99 APE9-dihe-na -70.4, 122.44 APE8-dihe-in -57.31, 154.98 APE8-rot-out 175.08 APE67-dihe-out -48.49, -76.95 -95.03, 72.04 APE12-dist-out 20.096 APE11-dist-out 18.5667 APE10-dist-out 14.8879 APE9-dist-out 10.3467 D475A,T743E None None XRAY 3.6 0.262 0.319 A 508.0 388.0 55 89 49 40 [[352, 672]] 1.0 4lqq Saccharomyces cerevisiae AGC_CBK1_YEAST AGC 8.9e-95 322.8 1.0 260.0 260.0 492 493 494 496 498 381 400 404 472 474 473 475.0 593 581 576 575 574 573 572 571 570 430 Serine/threonine-protein kinase CBK1
CAMK RAD53 RAD53_YEAST 4PDSA P22216 191 490 821.0 ANP:601 ATPlike None DFGin 6.8268 15.321 BLAminus -118.08, -171.61 59.64, 71.79 -99.48, 20.29 283.31, 64.09 -58.2, -44.36 in-none in 9.0663 Saltbr-none 999.0 HRD-in -71.09, -47.1 62.14, 17.47 none-in-none SNCnin in-none ActLoopNT-in 3.117 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -34.5 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 A225S,D339A None None XRAY 2.9 0.229 0.263 A 347.0 249.0 48 27 13 14 [[198, 466]] 1.0 4pds Saccharomyces cerevisiae CAMK_RAD53_YEAST CAMK 1e-76 264.0 3.0 256.0 254.0 338 339 340 342 344 227 244 248 316 318 317 319.0 390 365 360 359 358 357 356 355 354 274 Serine/threonine-protein kinase RAD53
CAMK RAD53 RAD53_YEAST 4PDSB P22216 191 494 821.0 ANP:601 ATPlike Inactive DFGin 6.7183 15.148 BLAminus -117.97, -170.55 58.98, 70.83 -99.5, 20.74 286.63, 66.01 -58.38, -47.1 in-none in 9.1835 Saltbr-none 999.0 HRD-in -70.11, -46.34 63.04, 16.89 none-in-out SNCnio in-out ActLoopNT-in 2.9807 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 171.9 APE8-rot-out 171.12 APE67-dihe-in -69.32, -29.11 -73.88, 11.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 A225S,D339A None None XRAY 2.9 0.229 0.263 B 347.0 248.0 52 27 15 12 [[198, 466]] 1.0 4pds Saccharomyces cerevisiae CAMK_RAD53_YEAST CAMK 1e-76 264.0 3.0 256.0 254.0 338 339 340 342 344 227 244 248 316 318 317 319.0 390 365 360 359 358 357 356 355 354 274 Serine/threonine-protein kinase RAD53
CAMK RAD53 RAD53_YEAST 5XZVB P22216 32 466 821.0 ANP:60501 ATPlike Inactive DFGin 7.5918 14.0173 BLBminus -134.96, 173.3 66.26, 62.64 -75.82, 145.77 303.09, 74.83 -59.73, 168.49 out-out out 13.6625 Saltbr-out 10.4743 HRD-in -60.41, -45.87 73.76, -6.4 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -100.72, 24.79 APE9-dihe-na -115.73, -142.38 APE8-dihe-in -94.48, 113.04 APE8-rot-in 308.94 APE67-dihe-in -48.8, -28.87 -80.72, -18.69 APE12-dist-in 12.6231 APE11-dist-out 16.6318 APE10-dist-out 16.163 APE9-dist-out 10.3293 None None None XRAY 3.1 0.273 0.289 B 471.0 370.0 29 27 16 11 [[198, 466]] 1.0 5xzv Saccharomyces cerevisiae CAMK_RAD53_YEAST CAMK 1.6e-78 269.9 3.0 256.0 254.0 338 339 340 342 344 227 244 248 316 318 317 319.0 390 365 360 359 358 357 356 355 354 274 Serine/threonine-protein kinase RAD53
CAMK RAD53 RAD53_YEAST 5XZVA P22216 16 465 821.0 ANP:60501 ATPlike Inactive DFGin 7.0643 15.2612 None -121.2, -53.4 -91.08, 125.25 -116.1, 93.37 279.98, 81.22 -112.86, 58.45 in-out in 9.8831 Saltbr-out 4.1817 HRD-out -106.71, 124.14 -85.03, 170.27 out-out-none SNCoon out-none ActLoopNT-out 5.5013 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -63.22, -40.45 999.0, 55.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.1 0.273 0.289 A 471.0 375.0 42 27 13 14 [[198, 466]] 1.0 5xzv Saccharomyces cerevisiae CAMK_RAD53_YEAST CAMK 1.6e-78 269.9 3.0 256.0 254.0 338 339 340 342 344 227 244 248 316 318 317 319.0 390 365 360 359 358 357 356 355 354 274 Serine/threonine-protein kinase RAD53
CMGC CKA1 CSK21_YEAST 4JQEA P15790 3 371 372.0 ANP:401 ATPlike Inactive None 24.2439 16.419 None -115.27, -174.34 56.63, 76.24 -90.39, 14.09 294.74, 85.98 -69.15, -20.82 out-na out 38.3713 Saltbr-na 999.0 HRD-in -70.11, -50.73 74.01, 10.07 na-in-in SNCaii in-in ActLoopNT-in 2.8729 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.74, -177.14 APE9-dihe-na 56.62, -167.2 APE8-dihe-in -120.8, 142.4 APE8-rot-in 319.02 APE67-dihe-in -66.52, -14.17 -32.33, -59.31 APE12-dist-in 12.3841 APE11-dist-in 10.3767 APE10-dist-in 6.0147 APE9-dist-in 3.0334 None None None XRAY 1.77 0.206 0.246 A 374.0 369.0 0 27 27 0 [[100, 363]] 1.0 4jqe Saccharomyces cerevisiae CMGC_CKA1_YEAST CMGC 0.0001 199.7 1.0 55.0 321.0 213 214 215 217 219 69 114 118 192 194 193 195.0 253 240 235 234 233 232 231 230 229 153 Casein kinase II subunit alpha
CMGC SKY1 SKY1_YEAST 1Q99A Q03656 143 737 742.0 ANP:60901 ATPlike Active DFGin 5.8628 12.8174 BLAminus -114.29, -177.44 55.8, 69.3 -86.87, 21.69 289.5, 16.74 -63.01, -13.14 in-in in 9.0097 Saltbr-in 3.3929 HRD-in -74.14, -46.77 73.71, -6.86 in-in-in SNCiii in-in ActLoopNT-in 2.9826 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.75, 166.8 APE9-dihe-na 68.75, 148.0 APE8-dihe-in -82.45, 139.06 APE8-rot-in 296.77 APE67-dihe-in -63.19, -13.43 -18.75, -76.87 APE12-dist-in 12.6355 APE11-dist-in 10.4413 APE10-dist-in 7.6775 APE9-dist-in 2.9962 None None None XRAY 2.11 0.22 0.26 A 373.0 354.0 9 25 25 0 [[158, 706]] 1.0 1q99 Saccharomyces cerevisiae CMGC_SKY1_YEAST CMGC 8.8e-100 339.7 1.0 301.0 301.0 549 550 551 553 555 187 202 206 291 293 292 294.0 586 574 569 568 567 566 565 564 563 247 Serine/threonine-protein kinase SKY1
CMGC SKY1 SKY1_YEAST 1Q99B Q03656 142 737 742.0 ANP:60902 ATPlike Active DFGin 6.0067 13.0756 BLAminus -119.51, 178.42 55.8, 73.86 -88.54, 22.76 281.2, 12.04 -67.31, -20.83 in-in in 8.9906 Saltbr-in 3.4133 HRD-in -77.35, -48.77 76.96, -6.7 in-in-in SNCiii in-in ActLoopNT-in 3.0544 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.48, 168.06 APE9-dihe-na 68.34, 160.67 APE8-dihe-in -99.08, 126.68 APE8-rot-in 289.43 APE67-dihe-in -64.6, -22.58 -5.08, -74.37 APE12-dist-in 12.5561 APE11-dist-in 10.3206 APE10-dist-in 7.7884 APE9-dist-in 3.1584 None None None XRAY 2.11 0.22 0.26 B 373.0 364.0 0 25 25 0 [[158, 706]] 1.0 1q99 Saccharomyces cerevisiae CMGC_SKY1_YEAST CMGC 8.8e-100 339.7 1.0 301.0 301.0 549 550 551 553 555 187 202 206 291 293 292 294.0 586 574 569 568 567 566 565 564 563 247 Serine/threonine-protein kinase SKY1
OTHER BUD32 BUD32_YEAST 4WW5A P53323 5 257 261.0 ANP:301 Type1.5_Front Active DFGin 6.7539 15.3715 BLAminus -131.59, 172.16 63.96, 73.04 -100.08, 21.32 284.27, 93.18 -51.84, -32.53 in-in in 7.6578 Saltbr-in 2.7833 HRD-in -80.73, -50.01 98.03, -11.27 in-in-na SNCiia in-na ActLoopNT-in 2.8804 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -64.97, -44.17 APE9-dihe-na -62.31, -41.0 APE8-dihe-na -66.43, -40.1 APE8-rot-na 172.1 APE67-dihe-na -63.36, -39.55 -55.34, -50.01 APE12-dist-na 15.7306 APE11-dist-na 11.1452 APE10-dist-na 14.7068 APE9-dist-na 11.7134 None None None XRAY 1.997 0.185 0.222 A 261.0 236.0 21 23 23 0 [[17, 261]] 1.0 4ww5 Saccharomyces cerevisiae OTHER_BUD32_YEAST TP53RK 5e-44 156.6 8.0 224.0 217.0 181 182 183 185 187 52 76 80 158 160 159 161.0 198 204 199 198 197 196 195 194 193 107 EKC/KEOPS complex subunit BUD32
OTHER GCN2-2 GCN2_YEAST 1ZY5A P15442 594 996 1659.0 ANP:60303 ATPlike Inactive DFGin 6.4358 13.9477 BLBminus -143.1, -168.47 53.69, 51.66 -54.84, 142.33 286.09, 71.25 -76.51, 124.09 out-out out 12.6608 Saltbr-out 11.0566 HRD-in -67.81, -47.78 76.36, -17.83 out-out-none SNCoon out-none ActLoopNT-out 8.5019 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -71.49, -10.61 999.0, -40.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 R794G None None XRAY 2.0 0.235 0.279 A 303.0 269.0 31 42 17 25 [[292, 527], [599, 981]] 2.0 1zy5 Saccharomyces cerevisiae OTHER_GCN2-2_YEAST STE 3.9e-47 167.3 1.0 254.0 254.0 852 853 854 856 858 628 643 647 832 834 833 835.0 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
OTHER GCN2-2 GCN2_YEAST 1ZY5B P15442 594 983 1659.0 ANP:60304 ATPlike Inactive DFGin 6.6025 13.914 BLBminus -140.22, -166.87 36.36, 56.71 -49.57, 149.56 284.28, 69.17 -88.92, 120.77 out-out out 12.8249 Saltbr-out 9.7993 HRD-in -69.22, -51.57 73.48, -3.27 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -57.67 APE8-dihe-out -69.97, -47.08 APE8-rot-out 170.45 APE67-dihe-in -61.67, -26.23 -38.97, -39.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.7538 R794G None None XRAY 2.0 0.235 0.279 B 303.0 247.0 40 42 13 29 [[292, 527], [599, 981]] 2.0 1zy5 Saccharomyces cerevisiae OTHER_GCN2-2_YEAST STE 3.9e-47 167.3 1.0 254.0 254.0 852 853 854 856 858 628 643 647 832 834 833 835.0 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
AGC PRKACA KAPCA_PIG 1CDKA P36887 9 351 351.0 ANP:60400 ATPlike Active DFGin 5.8431 14.3299 BLAminus -113.76, -166.2 47.38, 80.03 -85.76, 16.06 278.85, 56.4 -55.46, -28.11 in-in in 9.0339 Saltbr-in 2.8992 HRD-in -94.66, -56.81 78.16, -3.52 in-in-in SNCiii in-in ActLoopNT-in 2.9853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.51, 155.2 APE9-dihe-na 137.51, -153.75 APE8-dihe-in -125.49, 136.2 APE8-rot-in 297.83 APE67-dihe-in -73.46, -24.38 -35.73, -51.43 APE12-dist-in 7.9972 APE11-dist-in 11.4183 APE10-dist-in 5.7664 APE9-dist-in 3.6421 None TPO198 TPO198 XRAY 2.0 0.197 999.0 A 350.0 343.0 0 25 25 0 [[44, 298]] 1.0 1cdk Sus scrofa AGC_PRKACA_PIG AGC 3.5e-95 324.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_PIG 1CDKB P36887 9 351 351.0 ANP:60400 ATPlike Active DFGin 5.907 14.5106 BLAminus -124.27, -171.72 50.82, 76.29 -83.58, 17.26 280.88, 62.25 -47.74, -29.83 in-in in 8.889 Saltbr-in 2.8833 HRD-in -87.48, -57.48 77.49, 1.67 in-in-in SNCiii in-in ActLoopNT-in 2.9631 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.91, 159.84 APE9-dihe-na 137.3, -140.74 APE8-dihe-in -136.57, 132.27 APE8-rot-in 304.84 APE67-dihe-in -69.16, -27.96 -34.59, -53.92 APE12-dist-in 8.3483 APE11-dist-in 11.5142 APE10-dist-in 6.0801 APE9-dist-in 3.7441 None TPO198 TPO198 XRAY 2.0 0.197 999.0 B 350.0 343.0 0 25 25 0 [[44, 298]] 1.0 1cdk Sus scrofa AGC_PRKACA_PIG AGC 3.5e-95 324.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
OTHER RNASEL A5H025_PIG 4O1PA A5H025 22 729 743.0 ANP:901,25L:904 ATPlike,Allosteric Inactive DFGin 6.5106 12.9603 ABAminus -131.33, -33.02 -113.57, 101.31 -107.24, 17.35 306.62, 95.87 -64.46, -18.71 in-in in 7.0246 Saltbr-in 2.5592 HRD-in -60.39, -60.51 77.09, -8.47 in-in-na SNCiia in-na ActLoopNT-in 2.8318 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -142.96, 83.14 APE9-dihe-na -58.16, -26.45 APE8-dihe-na -61.31, -25.89 APE8-rot-na 201.37 APE67-dihe-na -54.23, -32.66 -72.61, -17.63 APE12-dist-na 15.865 APE11-dist-na 12.9589 APE10-dist-na 13.1315 APE9-dist-na 13.8672 None None None XRAY 2.5 0.198 0.231 A 717.0 672.0 4 20 20 0 [[351, 591]] 1.0 4o1p Sus scrofa OTHER_RNASEL_PIG RNASEL 2.2e-128 433.7 1.0 242.0 242.0 499 500 501 503 505 390 402 406 479 481 480 482.0 517 519 514 513 512 511 510 509 508 433 Ribonuclease L
OTHER RNASEL A5H025_PIG 4O1PB A5H025 22 729 743.0 ANP:901,25L:904 ATPlike,Allosteric Inactive DFGin 6.5583 12.9326 ABAminus -131.25, -34.01 -112.79, 101.17 -107.11, 16.68 306.49, 96.02 -64.91, -18.59 in-in in 7.0347 Saltbr-in 2.5611 HRD-in -55.77, -50.97 68.09, -3.12 in-in-na SNCiia in-na ActLoopNT-in 2.8687 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -144.24, 83.66 APE9-dihe-na -56.74, -27.11 APE8-dihe-na -62.19, -25.6 APE8-rot-na 202.01 APE67-dihe-na -55.19, -32.83 -72.11, -17.43 APE12-dist-na 15.8375 APE11-dist-na 12.884 APE10-dist-na 13.1268 APE9-dist-na 13.6898 None None None XRAY 2.5 0.198 0.231 B 717.0 671.0 3 20 20 0 [[351, 591]] 1.0 4o1p Sus scrofa OTHER_RNASEL_PIG RNASEL 2.2e-128 433.7 1.0 242.0 242.0 499 500 501 503 505 390 402 406 479 481 480 482.0 517 519 514 513 512 511 510 509 508 433 Ribonuclease L
OTHER RNASEL A5H025_PIG 4O1PC A5H025 22 729 743.0 ANP:901,25L:904 ATPlike,Allosteric Inactive DFGin 6.5736 12.9509 ABAminus -131.64, -33.31 -113.88, 102.15 -109.17, 16.76 306.25, 95.79 -63.9, -18.81 in-in in 7.0356 Saltbr-in 2.5563 HRD-in -57.15, -62.34 78.43, -4.0 in-in-na SNCiia in-na ActLoopNT-in 2.8402 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -142.78, 82.89 APE9-dihe-na -56.9, -26.71 APE8-dihe-na -61.49, -26.14 APE8-rot-na 201.42 APE67-dihe-na -54.45, -32.57 -72.46, -17.58 APE12-dist-na 15.8741 APE11-dist-na 12.9723 APE10-dist-na 13.1218 APE9-dist-na 13.7065 None None None XRAY 2.5 0.198 0.231 C 717.0 673.0 4 20 20 0 [[351, 591]] 1.0 4o1p Sus scrofa OTHER_RNASEL_PIG RNASEL 2.2e-128 433.7 1.0 242.0 242.0 499 500 501 503 505 390 402 406 479 481 480 482.0 517 519 514 513 512 511 510 509 508 433 Ribonuclease L
OTHER RNASEL A5H025_PIG 4O1PD A5H025 22 729 743.0 ANP:901,25L:904 ATPlike,Allosteric Inactive DFGin 6.5223 12.9182 ABAminus -132.11, -32.85 -113.92, 101.55 -106.16, 16.67 306.88, 96.47 -66.56, -17.9 in-in in 7.0247 Saltbr-in 2.5581 HRD-in -66.2, -51.02 69.27, -3.45 in-in-na SNCiia in-na ActLoopNT-in 2.837 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -143.98, 84.27 APE9-dihe-na -56.61, -27.19 APE8-dihe-na -61.86, -25.69 APE8-rot-na 201.6 APE67-dihe-na -54.63, -32.79 -72.23, -18.0 APE12-dist-na 15.8126 APE11-dist-na 12.7951 APE10-dist-na 13.0985 APE9-dist-na 13.6043 None None None XRAY 2.5 0.198 0.231 D 717.0 668.0 5 20 20 0 [[351, 591]] 1.0 4o1p Sus scrofa OTHER_RNASEL_PIG RNASEL 2.2e-128 433.7 1.0 242.0 242.0 499 500 501 503 505 390 402 406 479 481 480 482.0 517 519 514 513 512 511 510 509 508 433 Ribonuclease L
OTHER TCUR0376 D1A2F7_THECD 8CAVA D1A2F7 6 865 865.0 ANP:61003 Allosteric Inactive DFGout 25.0288 13.8059 None -136.61, -176.07 50.55, 90.07 -109.52, 39.53 298.71, 97.0 -61.52, -45.79 out-na out 23.3041 Saltbr-na 999.0 HRD-in -69.88, -46.85 69.44, -25.22 na-in-out SNCaio in-out ActLoopNT-in 3.0456 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na 151.19, 133.67 APE9-dihe-na -156.32, 163.61 APE8-dihe-in -115.94, 119.26 APE8-rot-in 286.11 APE67-dihe-inflip 85.43, -34.6 -53.57, 131.45 APE12-dist-out 4.1645 APE11-dist-in 8.3427 APE10-dist-in 6.3115 APE9-dist-in 5.6421 None None None XRAY 2.87 0.24 0.293 A 865.0 860.0 0 23 23 0 [[216, 447]] 1.0 8cav Thermomonospora curvata OTHER_TCUR0376_THECD OTHER 2.3e-11 51.4 3.0 202.0 200.0 367 368 369 371 373 245 255 255 346 348 347 349.0 402 390 385 384 383 382 381 380 379 255 Serine/threonine protein kinase
OTHER TCUR0376 D1A2F7_THECD 8CAVB D1A2F7 6 863 865.0 ANP:61102 Allosteric Inactive DFGout 25.219 13.2725 None -136.17, 0.21 -151.94, 106.25 -116.71, 46.61 337.45, 77.06 -61.98, -44.38 out-na out 23.2159 Saltbr-na 999.0 HRD-in -72.63, -51.39 72.73, -38.34 na-in-out SNCaio in-out ActLoopNT-in 3.126 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na 155.97, 136.86 APE9-dihe-na -156.68, 147.71 APE8-dihe-in -106.12, 118.89 APE8-rot-in 302.92 APE67-dihe-inflip 84.82, -43.75 -50.92, 139.58 APE12-dist-out 4.0314 APE11-dist-in 8.2152 APE10-dist-in 6.5289 APE9-dist-in 5.9687 None None None XRAY 2.87 0.24 0.293 B 865.0 858.0 0 23 23 0 [[216, 447]] 1.0 8cav Thermomonospora curvata OTHER_TCUR0376_THECD OTHER 2.3e-11 51.4 3.0 202.0 200.0 367 368 369 371 373 245 255 255 346 348 347 349.0 402 390 385 384 383 382 381 380 379 255 Serine/threonine protein kinase
CAMK CDPK1 Q9BJF5_TOXGO 4IEBA Q9BJF5 32 507 507.0 ANP:60605 ATPlike Inactive DFGin 6.5537 15.7608 BLAminus -118.12, -178.54 57.22, 81.05 -93.39, 22.31 283.83, 75.07 -62.91, -21.06 out-out out 10.7859 Saltbr-out 8.1831 HRD-in -78.1, -52.4 75.27, -1.01 out-in-in SNCoii in-in ActLoopNT-in 2.9719 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.38, 132.65 APE9-dihe-na 150.75, -159.18 APE8-dihe-in -127.81, 136.94 APE8-rot-in 296.09 APE67-dihe-in -59.35, -29.22 -49.66, -52.18 APE12-dist-in 8.747 APE11-dist-in 11.8763 APE10-dist-in 6.0733 APE9-dist-in 3.6857 G128M None None XRAY 2.05 0.176 0.217 A 515.0 471.0 4 27 27 0 [[51, 308]] 1.0 4ieb Toxoplasma gondii CAMK_CDPK1_TOXGO CAMK 1.4e-91 312.8 1.0 256.0 256.0 194 195 196 198 200 80 99 103 171 173 172 174.0 232 221 216 215 214 213 212 211 210 129 non-specific serine/threonine protein kinase
CAMK CDPK1 Q9BJF5_TOXGO 3HX4A Q9BJF5 30 503 507.0 ANP:605 ATPlike Inactive DFGin 6.3758 15.5972 BLAminus -124.93, -178.11 57.55, 76.18 -93.17, 21.06 281.41, 72.38 -57.25, -28.44 out-out out 10.4296 Saltbr-out 8.0819 HRD-in -82.41, -52.5 74.03, -1.03 out-in-in SNCoii in-in ActLoopNT-in 2.926 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.23, 136.25 APE9-dihe-na 150.35, -156.09 APE8-dihe-in -126.64, 138.87 APE8-rot-in 302.17 APE67-dihe-in -62.12, -29.95 -51.48, -47.24 APE12-dist-in 8.5825 APE11-dist-in 12.0547 APE10-dist-in 6.1884 APE9-dist-in 3.6455 None None None XRAY 1.95 0.212 0.257 A 508.0 467.0 7 27 27 0 [[51, 308]] 1.0 3hx4 Toxoplasma gondii CAMK_CDPK1_TOXGO CAMK 5.2e-90 307.5 1.0 256.0 256.0 194 195 196 198 200 80 99 103 171 173 172 174.0 232 221 216 215 214 213 212 211 210 129 non-specific serine/threonine protein kinase
CAMK CDPK1 Q9BJF5_TOXGO 3KU2A Q9BJF5 44 507 507.0 ANP:508 ATPlike Inactive None 11.4771 17.9385 None -100.99, 156.17 73.53, 18.21 -64.25, 133.09 244.39, 100.2 75.66, -4.53 out-none out 14.4969 Saltbr-none 999.0 HRD-in -80.49, -57.8 77.94, -40.26 none-out-out SNCnoo out-out ActLoopNT-out 5.7208 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -61.85, 129.57 APE9-dihe-na 74.83, 23.66 APE8-dihe-out -106.17, -37.64 APE8-rot-out 63.52 APE67-dihe-in -62.81, -37.67 -61.55, -28.62 APE12-dist-out 14.0548 APE11-dist-out 16.6555 APE10-dist-out 19.0687 APE9-dist-out 12.0419 None None None XRAY 2.3 0.198 0.236 A 507.0 457.0 0 27 27 0 [[51, 308]] 1.0 3ku2 Toxoplasma gondii CAMK_CDPK1_TOXGO CAMK 5.2e-90 307.5 1.0 256.0 256.0 194 195 196 198 200 80 99 103 171 173 172 174.0 232 221 216 215 214 213 212 211 210 129 non-specific serine/threonine protein kinase
OTHER ROP18 ROP18_TOXGO 4JRNA Q2PAY2 187 548 554.0 ANP:601 Allosteric None DFGin 8.9824 15.8688 BLAminus -128.68, -167.44 58.76, 57.13 -87.53, 25.8 281.08, 82.06 -67.92, -21.93 in-in in 8.1829 Saltbr-in 2.9919 HRD-in -70.13, -31.0 63.02, -2.32 in-in-none SNCiin in-none ActLoopNT-in 2.3841 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_inni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 178.51 APE8-dihe-in -78.23, 127.04 APE8-rot-in 289.7 APE67-dihe-inflip 110.21, -8.27 -63.71, 127.69 APE12-dist-in 10.0073 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.2757 None None None XRAY 2.71 0.235 0.289 A 372.0 349.0 6 24 22 2 [[253, 531]] 1.0 4jrn Toxoplasma gondii OTHER_ROP18_TOXGO CAMK 0.04 76.6 5.0 55.0 197.0 426 427 428 430 432 281 300 304 406 408 407 409.0 465 450 445 444 443 442 441 440 439 0 Serine/threonine-protein kinase ROP18
OTHER PINK1 PINK1_TRICA 5YJ9D D6WMX4 166 570 570.0 ANP:601 ATPlike Inactive DFGin 9.5017 15.2831 ABAminus -117.37, -38.64 -95.18, 97.77 -99.2, 13.92 280.74, 77.89 -62.77, -17.79 in-in in 7.8359 Saltbr-in 2.5799 HRD-out -70.37, 137.63 -130.59, 22.41 in-in-out SNCiio in-out ActLoopNT-in 2.5791 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_iiii APE10-dihe-na -154.61, -176.52 APE9-dihe-na -54.92, 113.48 APE8-dihe-in -53.26, 148.57 APE8-rot-na 309.64 APE67-dihe-out -106.62, -9.97 -172.9, 165.52 APE12-dist-in 7.9748 APE11-dist-in 11.272 APE10-dist-in 7.1591 APE9-dist-in 3.2168 S205D,S377D,T386E,T530E None MSE197,MSE198,MSE208,MSE214,MSE223,MSE288,MSE294,MSE328,MSE380,MSE389 XRAY 2.53 0.23 0.243 D 423.0 343.0 56 34 34 0 [[61, 504]] 1.0 5yj9 Tribolium castaneum OTHER_PINK1_TRICA PINK1 5.8e-86 294.6 5.0 367.0 363.0 358 359 360 362 364 196 217 221 334 336 335 337.0 410 392 387 386 385 384 383 382 381 295 Serine/threonine-protein kinase Pink1, mitochondrial
CMGC TVAG125560 A2F9N1_TRIV3 9AV7A A2F9N1 15 318 320.0 ANP:401 ATPlike Active DFGin 7.6357 16.4242 BLAminus -120.42, -177.29 61.53, 69.44 -89.47, 18.08 296.84, 80.84 -66.47, -28.11 in-in in 9.4621 Saltbr-in 3.0921 HRD-in -77.85, -46.91 69.04, 9.93 in-in-in SNCiii in-in ActLoopNT-in 2.9544 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.39, -177.21 APE9-dihe-na 62.4, -175.9 APE8-dihe-in -115.65, 153.97 APE8-rot-in 297.25 APE67-dihe-inflip 82.79, -6.3 -53.46, 134.7 APE12-dist-in 12.6952 APE11-dist-in 10.4962 APE10-dist-in 6.3173 APE9-dist-in 3.0126 None None None XRAY 2.1 0.202 0.246 A 328.0 304.0 0 27 27 0 [[27, 312]] 1.0 9av7 Trichomonas vaginalis CMGC_TVAG125560_TRIV3 CMGC 2.3e-51 180.8 1.0 301.0 301.0 162 163 164 166 168 56 69 73 141 143 142 144.0 202 189 184 183 182 181 180 179 178 102 non-specific serine/threonine protein kinase
CAMK AURKBA AUKBA_XENLA 4C2WA Q6DE08 88 356 361.0 ANP:1001 ATPlike Inactive DFGin 5.5245 15.7899 ABAminus -114.94, -31.28 -113.37, 121.43 -114.18, 23.33 282.52, 84.1 -51.89, -43.92 out-out out 11.2684 Saltbr-out 4.9732 HRD-in -79.83, -53.41 73.71, 4.05 out-in-in SNCoii in-in ActLoopNT-in 2.893 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.21, 165.55 APE9-dihe-na 112.48, -144.66 APE8-dihe-in -138.33, 133.06 APE8-rot-in 294.04 APE67-dihe-in -66.35, -18.01 -34.41, -59.11 APE12-dist-in 8.359 APE11-dist-in 10.9412 APE10-dist-in 5.5314 APE9-dist-in 3.5614 None TPO248 TPO248 XRAY 1.7 0.158 0.195 A 279.0 269.0 0 26 26 0 [[93, 343]] 1.0 4c2w Xenopus laevis CAMK_AURKBA_XENLA CAMK 2.3e-77 265.7 1.0 256.0 256.0 233 234 235 237 239 122 141 145 213 215 214 216.0 271 259 254 253 252 251 250 249 248 171 Aurora kinase B-A
CAMK AURKBA AUKBA_XENLA 4C2WB Q6DE08 78 355 361.0 ANP:1002 ATPlike Inactive DFGin 5.81 15.7867 ABAminus -118.01, -19.02 -130.42, 119.39 -114.99, 28.58 284.95, 75.85 -64.5, -21.38 out-out out 10.7632 Saltbr-out 4.7398 HRD-in -76.03, -52.74 71.93, -3.36 out-in-in SNCoii in-in ActLoopNT-in 2.9194 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.86, 167.53 APE9-dihe-na 123.0, -151.95 APE8-dihe-in -138.83, 132.09 APE8-rot-in 301.48 APE67-dihe-in -63.95, -21.5 -45.73, -54.15 APE12-dist-in 8.0417 APE11-dist-in 10.7689 APE10-dist-in 5.3227 APE9-dist-in 3.6059 None TPO248 TPO248 XRAY 1.7 0.158 0.195 B 279.0 278.0 0 26 26 0 [[93, 343]] 1.0 4c2w Xenopus laevis CAMK_AURKBA_XENLA CAMK 2.3e-77 265.7 1.0 256.0 256.0 233 234 235 237 239 122 141 145 213 215 214 216.0 271 259 254 253 252 251 250 249 248 171 Aurora kinase B-A
CMGC ACK2 CSK2A_MAIZE 1DAWA P28523 2 328 332.0 ANP:60340 ATPlike Inactive DFGin 7.4789 16.2531 BLAminus -105.07, -177.02 59.3, 78.28 -93.62, 17.81 300.8, 85.23 -64.69, -25.71 in-in in 9.0445 Saltbr-in 2.6139 HRD-in -71.54, -56.91 74.99, 12.33 in-in-out SNCiio in-out ActLoopNT-in 2.6533 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -145.67, 164.1 APE9-dihe-na 63.95, 166.03 APE8-dihe-in -78.9, 151.56 APE8-rot-out 157.17 APE67-dihe-in -65.06, -18.37 -51.17, -45.02 APE12-dist-in 12.4577 APE11-dist-in 10.113 APE10-dist-in 6.0173 APE9-dist-in 3.0963 None None None XRAY 2.2 0.223 0.285 A 327.0 327.0 0 27 27 0 [[34, 319]] 1.0 1daw Zea mays CMGC_ACK2_MAIZE CMGC 1.7e-65 227.1 1.0 301.0 301.0 169 170 171 173 175 63 76 80 148 150 149 151.0 209 196 191 190 189 188 187 186 185 109 Casein kinase II subunit alpha
CMGC ACK2 CSK2A_MAIZE 1LP4A P28523 2 328 332.0 ANP:60340 ATPlike Inactive DFGin 7.3844 16.4369 BLAminus -105.48, -174.19 57.32, 75.68 -95.1, 15.33 299.18, 80.31 -67.7, -16.27 in-in in 8.951 Saltbr-in 2.9287 HRD-in -74.21, -49.64 68.44, 10.87 in-in-out SNCiio in-out ActLoopNT-in 2.7917 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.52, 168.08 APE9-dihe-na 65.54, 161.64 APE8-dihe-in -72.4, 142.48 APE8-rot-out 152.04 APE67-dihe-in -70.58, -15.11 -42.33, -45.49 APE12-dist-in 12.4105 APE11-dist-in 10.0413 APE10-dist-in 6.0356 APE9-dist-in 3.1383 None None None XRAY 1.86 0.207 0.244 A 332.0 327.0 0 27 27 0 [[34, 319]] 1.0 1lp4 Zea mays CMGC_ACK2_MAIZE CMGC 1.8e-65 227.0 1.0 301.0 301.0 169 170 171 173 175 63 76 80 148 150 149 151.0 209 196 191 190 189 188 187 186 185 109 Casein kinase II subunit alpha
OTHER SIRK1 K7VIQ3_MAIZE 5UV4A K7VIQ3 744 1045 1045.0 ANP:1101 ATPlike Pseudo DFGin 4.8784 12.8015 BLBplus -120.34, 177.7 46.93, 54.84 -91.14, 142.45 62.71, 98.99 59.6, 31.25 out-out out 15.1466 Saltbr-out 17.5322 HRD-in -68.43, -62.74 80.25, -5.53 out-out-out SNCooo out-out ActLoopNT-out 7.1596 ActLoopCT-out nonTYR APEdihe_aaono APEdist_oioo APE10-dihe-na -63.26, -37.61 APE9-dihe-na -61.51, -44.79 APE8-dihe-out -63.05, -40.24 APE8-rot-none 999.0 APE67-dihe-out 86.33, 22.47 -82.94, -6.82 APE12-dist-out 14.6572 APE11-dist-in 12.4356 APE10-dist-out 11.8497 APE9-dist-out 10.4225 None None None XRAY 2.3 0.184 0.211 A 311.0 290.0 12 29 29 0 [[757, 1042]] 1.0 5uv4 Zea mays OTHER_SIRK1_MAIZE TKL 1.6e-38 138.7 5.0 265.0 261.0 906 907 908 910 912 789 805 809 885 887 886 888.0 949 935 930 929 928 927 926 925 924 837 Putative leucine-rich repeat protein kinase family protein