Ligand: ANP

Total number of chains: 394
Active chains: 62
Total number of genes: 79
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 160 40.6% 8QCGA
DFGin BLBplus 140 35.5% 2SRCA
DFGin BLBtrans 31 7.9% 5X2AB
DFGin None 22 5.6% 6BXIA
DFGin ABAminus 16 4.1% 8R5EA
DFGinter None 10 2.5% 7OPOG
DFGin BLAplus 5 1.3% 2OZOA
DFGin BLBminus 5 1.3% 4LGDA
None None 3 0.8% 7F2XA
DFGout None 2 0.5% 6VPHA
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC AKT1 AKT1_HUMAN 4EKKA P31749 144 477 480.0 ANP:60501 ATPlike Active DFGin 6.048 13.113 BLAminus -112.5, -177.27 66.46, 90.66 -111.95, 23.34 296.26, 86.16 -69.26, -23.9 in-in in 8.651 Saltbr-in 2.978 HRD-in -63.51, -40.13 66.5, -18.58 in-in-in SNCiii in-in ActLoopNT-in 3.05 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.71, 172.01 APE9-dihe-na 121.09, -152.4 APE8-dihe-in -119.32, 125.09 APE8-rot-in 285.38 APE67-dihe-in -63.61, -25.53 -44.69, -42.52 APE12-dist-in 8.814 APE11-dist-in 11.718 APE10-dist-in 6.07 APE9-dist-in 4.069 S473D TPO308 TPO308 XRAY 2.8 0.22 0.28 A 341 319 0 0 0 0 [[150, 408]] 1.0 4ekk AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 4EKKB P31749 144 477 480.0 ANP:60501 ATPlike Active DFGin 6.075 13.046 BLAminus -112.98, 175.61 60.18, 117.01 -127.72, 18.67 304.81, 92.19 -54.85, -36.32 in-in in 8.766 Saltbr-in 2.665 HRD-in -65.56, -47.0 73.75, -27.2 in-in-in SNCiii in-in ActLoopNT-in 2.819 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.2, 164.76 APE9-dihe-na 136.6, -155.35 APE8-dihe-in -114.57, 129.15 APE8-rot-in 273.31 APE67-dihe-in -63.86, -22.96 -45.74, -46.48 APE12-dist-in 8.77 APE11-dist-in 11.686 APE10-dist-in 6.125 APE9-dist-in 4.285 S473D TPO308 TPO308 XRAY 2.8 0.22 0.28 B 341 319 0 0 0 0 [[150, 408]] 1.0 4ekk AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 1O6KA P31751 146 479 481.0 ANP:1480 ATPlike Active DFGin 6.146 12.734 BLAminus -120.8, -176.05 56.87, 82.9 -98.82, 24.49 299.36, 92.56 -61.37, -25.29 in-in in 8.749 Saltbr-in 2.796 HRD-in -73.34, -45.79 65.54, -9.2 in-in-in SNCiii in-in ActLoopNT-in 3.027 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.85, 170.7 APE9-dihe-na 130.02, -155.15 APE8-dihe-in -119.36, 127.57 APE8-rot-in 291.96 APE67-dihe-in -68.55, -16.48 -36.55, -56.12 APE12-dist-in 8.193 APE11-dist-in 11.759 APE10-dist-in 6.119 APE9-dist-in 3.921 S474D TPO309 TPO309 XRAY 1.7 0.205 0.234 A 336 318 0 0 0 0 [[152, 409]] 1.0 1o6k AGC_AKT2_HUMAN AGC 1.7e-99 338.1 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 1O6LA P31751 146 477 481.0 ANP:61480 ATPlike Active DFGin 6.258 12.925 BLAminus -121.53, -178.18 58.41, 83.34 -98.83, 24.71 297.57, 89.85 -63.5, -19.94 in-in in 8.794 Saltbr-in 2.76 HRD-in -74.06, -43.29 62.88, -5.6 in-in-in SNCiii in-in ActLoopNT-in 3.006 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.79, 169.91 APE9-dihe-na 133.49, -153.33 APE8-dihe-in -120.8, 127.55 APE8-rot-in 289.07 APE67-dihe-in -68.04, -17.15 -37.13, -54.04 APE12-dist-in 8.173 APE11-dist-in 11.74 APE10-dist-in 6.122 APE9-dist-in 3.747 None TPO309 TPO309 XRAY 1.6 0.198 0.227 A 337 312 0 0 0 0 [[152, 409]] 1.0 1o6l AGC_AKT2_HUMAN AGC 1.8e-99 338.1 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC GRK5 GRK5_HUMAN 4TNDA P34947 15 543 590.0 ANP:601 ATPlike Active DFGin 5.282 13.172 BLAminus -119.9, 173.82 59.88, 73.64 -89.53, 7.87 278.21, 112.8 -54.71, -33.69 in-in in 9.193 Saltbr-in 3.053 HRD-in -67.8, -56.87 74.64, -6.61 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.25, 150.21 APE9-dihe-na 143.02, -165.26 APE8-dihe-in -107.11, 142.28 APE8-rot-in 314.69 APE67-dihe-inflip 92.64, -22.22 -59.58, 132.94 APE12-dist-in 10.302 APE11-dist-in 12.056 APE10-dist-in 6.23 APE9-dist-in 4.255 None None None XRAY 1.802 0.174 0.205 A 590 529 0 0 0 0 [[186, 448]] 1.0 4tnd AGC_GRK5_HUMAN AGC 1.1e-83 286.4 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK6 GRK6_HUMAN 2ACXA P43250 14 532 576.0 ANP:577 ATPlike Active DFGin 6.207 13.284 BLAminus -133.82, 164.79 58.79, 76.03 -96.19, 24.41 281.42, 82.4 -59.68, -24.05 in-in in 9.341 Saltbr-in 3.219 HRD-in -78.26, -56.85 77.2, -1.95 in-in-in SNCiii in-in ActLoopNT-in 2.971 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.49, 157.4 APE9-dihe-na 123.02, -168.26 APE8-dihe-in -95.03, 140.31 APE8-rot-in 303.17 APE67-dihe-in -86.56, -0.13 -45.11, -52.69 APE12-dist-in 10.478 APE11-dist-in 11.834 APE10-dist-in 6.083 APE9-dist-in 3.906 C561S,C562S,C565S None None XRAY 2.6 0.204 0.243 A 576 495 0 0 0 0 [[186, 448]] 1.0 2acx AGC_GRK6_HUMAN AGC 2e-85 292.1 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 6
AGC GRK6 GRK6_HUMAN 2ACXB P43250 14 535 576.0 ANP:577 ATPlike Active DFGin 6.09 13.146 BLAminus -128.37, 163.87 55.35, 87.14 -100.56, 21.26 285.61, 77.77 -55.4, -30.56 in-in in 9.231 Saltbr-in 2.439 HRD-in -77.3, -59.12 75.78, 1.97 in-in-in SNCiii in-in ActLoopNT-in 2.977 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.83, 161.38 APE9-dihe-na 125.99, -167.44 APE8-dihe-in -95.89, 144.8 APE8-rot-in 307.19 APE67-dihe-in -70.72, -14.39 -48.06, -55.51 APE12-dist-in 10.477 APE11-dist-in 11.872 APE10-dist-in 6.167 APE9-dist-in 3.71 C561S,C562S,C565S None None XRAY 2.6 0.204 0.243 B 576 492 5 0 0 0 [[186, 448]] 1.0 2acx AGC_GRK6_HUMAN AGC 2e-85 292.1 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 6
AGC PRKCB KPCB_HUMAN 8SE1A P05771 19 668 671.0 ANP:60706 ATPlike Active DFGin 6.007 12.839 BLAminus -130.5, -169.38 54.07, 70.37 -91.85, 35.76 301.77, 99.49 -89.35, 3.84 in-in in 8.337 Saltbr-in 2.524 HRD-in -91.65, -37.95 43.68, 28.8 in-in-in SNCiii in-in ActLoopNT-in 3.16 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.86, 170.42 APE9-dihe-na 126.28, -151.58 APE8-dihe-in -120.81, 128.88 APE8-rot-in 299.44 APE67-dihe-in -79.06, -41.06 -50.17, -27.42 APE12-dist-in 8.88 APE11-dist-in 12.178 APE10-dist-in 6.66 APE9-dist-in 3.611 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 3.32 0.202 0.256 A 674 607 0 0 0 0 [[342, 600]] 1.0 8se1 AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC PRKCB KPCB_HUMAN 8SE1B P05771 19 668 671.0 ANP:60706 ATPlike Active DFGin 6.093 12.778 BLAminus -130.75, -169.0 53.85, 70.09 -92.15, 34.96 301.62, 99.67 -90.48, 2.45 in-in in 8.312 Saltbr-in 2.216 HRD-in -89.42, -35.84 47.27, 23.7 in-in-in SNCiii in-in ActLoopNT-in 3.284 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.83, 169.92 APE9-dihe-na 126.33, -152.59 APE8-dihe-in -121.43, 128.62 APE8-rot-in 299.3 APE67-dihe-in -78.67, -41.09 -50.34, -26.64 APE12-dist-in 8.722 APE11-dist-in 12.182 APE10-dist-in 6.709 APE9-dist-in 3.767 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 3.32 0.202 0.256 B 674 631 0 0 0 0 [[342, 600]] 1.0 8se1 AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC PRKCB KPCB_HUMAN 8SE2B P05771 30 671 671.0 ANP:701 ATPlike Active DFGin 5.706 12.737 BLAminus -122.79, -175.57 50.54, 85.22 -103.07, 33.77 300.25, 95.58 -78.87, -5.25 in-in in 8.251 Saltbr-in 2.675 HRD-in -90.05, -48.77 75.62, -5.68 in-in-in SNCiii in-in ActLoopNT-in 3.126 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.22, 161.28 APE9-dihe-na 125.49, -179.08 APE8-dihe-in -100.09, 129.99 APE8-rot-in 297.02 APE67-dihe-in -66.56, -21.71 -49.98, -38.79 APE12-dist-in 8.634 APE11-dist-in 11.712 APE10-dist-in 6.223 APE9-dist-in 3.606 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 2.95 0.196 0.252 B 672 589 0 0 0 0 [[342, 600]] 1.0 8se2 AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC PRKCI KPCI_HUMAN 8R3YI P41743 248 585 596.0 ANP:60601 ATPlike Inactive DFGin 6.372 12.488 ABAminus -142.84, 3.21 -114.63, 115.49 -97.57, 12.92 307.39, 117.32 -57.63, -54.79 in-out in 9.816 Saltbr-out 4.241 HRD-in -70.43, -26.71 66.29, -17.13 out-in-in SNCoii in-in ActLoopNT-in 2.908 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.32, 161.33 APE9-dihe-na 102.59, 162.36 APE8-dihe-in -70.48, 133.74 APE8-rot-in 297.7 APE67-dihe-in -64.44, -18.95 -54.13, -38.16 APE12-dist-in 8.863 APE11-dist-in 11.282 APE10-dist-in 5.856 APE9-dist-in 3.498 None TPO412,TPO564 TPO412,TPO564 EM 3.68 999.0 999.0 I 338 338 0 0 0 0 [[254, 522]] 1.0 8r3y AGC_PRKCI_HUMAN AGC 1e-95 325.7 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 5LI1A P41743 248 589 596.0 ANP:60601 ATPlike Active DFGin 5.079 11.961 BLAminus -129.24, 176.98 73.22, 90.17 -103.83, 11.43 308.18, 130.49 -69.42, -18.98 in-in in 8.413 Saltbr-in 2.816 HRD-in -77.28, -52.44 73.77, 3.75 in-in-in SNCiii in-in ActLoopNT-in 2.975 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.65, 168.01 APE9-dihe-na 127.57, -168.6 APE8-dihe-in -111.48, 126.0 APE8-rot-in 296.01 APE67-dihe-in -54.62, -31.15 -46.95, -45.66 APE12-dist-in 8.752 APE11-dist-in 11.822 APE10-dist-in 6.31 APE9-dist-in 3.517 None TPO412,SEP484,TPO564 TPO412,SEP484,TPO564 XRAY 2.0 0.154 0.217 A 354 332 10 0 0 0 [[254, 522]] 1.0 5li1 AGC_PRKCI_HUMAN AGC 1.2e-95 325.5 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKG1 KGP1_HUMAN 6BG2A Q13976 336 671 671.0 ANP:700 ATPlike Active DFGin 5.811 14.714 BLAminus -124.15, 169.14 66.07, 88.5 -100.57, 30.98 280.35, 66.41 -65.35, -25.12 in-in in 9.522 Saltbr-in 2.883 HRD-in -85.83, -52.95 73.29, 9.38 in-in-in SNCiii in-in ActLoopNT-in 2.851 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.93, 165.57 APE9-dihe-na 117.74, 172.78 APE8-dihe-in -83.6, 129.51 APE8-rot-in 307.46 APE67-dihe-in -66.9, -19.23 -49.63, -41.3 APE12-dist-in 8.235 APE11-dist-in 11.512 APE10-dist-in 6.041 APE9-dist-in 4.269 None TPO517 TPO517 XRAY 1.83 0.188 0.215 A 347 336 0 0 0 0 [[360, 619]] 1.0 6bg2 AGC_PRKG1_HUMAN AGC 2.6e-84 288.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 6BG2B Q13976 346 671 671.0 ANP:700 ATPlike Active DFGin 6.001 13.81 BLAminus -122.67, 175.58 65.94, 84.43 -99.77, 30.78 285.96, 70.42 -64.93, -24.07 in-in in 8.944 Saltbr-in 2.743 HRD-in -86.95, -52.47 73.99, 7.96 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.61, 163.67 APE9-dihe-na 118.96, 172.39 APE8-dihe-in -86.94, 131.94 APE8-rot-in 306.51 APE67-dihe-in -68.79, -20.88 -48.58, -41.68 APE12-dist-in 7.826 APE11-dist-in 11.215 APE10-dist-in 5.769 APE9-dist-in 4.008 None TPO517 TPO517 XRAY 1.83 0.188 0.215 B 347 326 0 0 0 0 [[360, 619]] 1.0 6bg2 AGC_PRKG1_HUMAN AGC 2.6e-84 288.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 6BG2C Q13976 337 671 671.0 ANP:700 ATPlike Active DFGin 5.746 14.057 BLAminus -122.99, 175.03 65.66, 84.22 -99.61, 30.7 281.62, 66.26 -64.81, -23.57 in-in in 8.742 Saltbr-in 2.723 HRD-in -85.99, -53.51 74.31, 7.4 in-in-in SNCiii in-in ActLoopNT-in 2.951 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.66, 165.85 APE9-dihe-na 118.46, 173.18 APE8-dihe-in -87.41, 130.75 APE8-rot-in 306.63 APE67-dihe-in -67.71, -19.03 -48.39, -42.55 APE12-dist-in 7.972 APE11-dist-in 11.385 APE10-dist-in 5.857 APE9-dist-in 3.861 None TPO517 TPO517 XRAY 1.83 0.188 0.215 C 347 335 0 0 0 0 [[360, 619]] 1.0 6bg2 AGC_PRKG1_HUMAN AGC 2.6e-84 288.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 6BG2D Q13976 344 671 671.0 ANP:700 ATPlike Active DFGin 5.71 14.012 BLAminus -124.49, 174.79 65.67, 84.87 -99.37, 30.45 283.38, 66.11 -64.13, -22.3 in-in in 8.754 Saltbr-in 2.644 HRD-in -85.68, -52.69 74.16, 8.99 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.92, 166.42 APE9-dihe-na 119.53, 169.97 APE8-dihe-in -84.81, 130.45 APE8-rot-in 305.19 APE67-dihe-in -66.29, -19.88 -48.13, -43.31 APE12-dist-in 7.988 APE11-dist-in 11.327 APE10-dist-in 5.784 APE9-dist-in 3.81 None TPO517 TPO517 XRAY 1.83 0.188 0.215 D 347 328 0 0 0 0 [[360, 619]] 1.0 6bg2 AGC_PRKG1_HUMAN AGC 2.6e-84 288.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7LV3A Q13976 57 671 671.0 ANP:60803 ATPlike Active DFGin 5.851 14.036 BLAminus -116.97, 177.04 63.26, 88.72 -106.87, 28.72 283.22, 63.7 -62.95, -24.33 in-in in 8.624 Saltbr-in 2.891 HRD-in -87.82, -54.22 74.26, 7.32 in-in-in SNCiii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.28, 149.98 APE9-dihe-na 157.95, -145.59 APE8-dihe-in -124.73, 128.61 APE8-rot-in 299.79 APE67-dihe-in -58.37, -20.06 -47.89, -51.97 APE12-dist-in 7.972 APE11-dist-in 11.057 APE10-dist-in 5.469 APE9-dist-in 3.811 None TPO517 TPO517 XRAY 2.41 0.201 0.238 A 617 600 0 0 0 0 [[360, 619]] 1.0 7lv3 AGC_PRKG1_HUMAN AGC 1.3e-83 286.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7LV3B Q13976 58 671 671.0 ANP:60803 ATPlike Active DFGin 5.634 13.962 BLAminus -116.52, 178.28 63.3, 90.17 -108.68, 29.08 283.48, 65.02 -62.88, -23.93 in-in in 8.883 Saltbr-in 2.824 HRD-in -86.48, -52.9 74.97, 7.4 in-in-in SNCiii in-in ActLoopNT-in 2.959 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.28, 149.21 APE9-dihe-na 157.62, -145.94 APE8-dihe-in -123.75, 129.22 APE8-rot-in 300.73 APE67-dihe-in -59.05, -19.44 -46.41, -52.49 APE12-dist-in 8.134 APE11-dist-in 11.198 APE10-dist-in 5.604 APE9-dist-in 3.787 None TPO517 TPO517 XRAY 2.41 0.201 0.238 B 617 593 0 0 0 0 [[360, 619]] 1.0 7lv3 AGC_PRKG1_HUMAN AGC 1.3e-83 286.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC ROCK1 ROCK1_HUMAN 2V55A Q13464 6 404 1354.0 ANP:1480 ATPlike Active DFGin 5.88 13.604 BLAminus -137.29, -177.31 60.22, 109.9 -132.74, 24.25 290.89, 71.12 -53.92, -52.21 in-in in 9.076 Saltbr-in 2.708 HRD-in -79.75, -71.28 93.49, -31.37 in-in-in SNCiii in-in ActLoopNT-in 3.281 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.46, 139.75 APE9-dihe-na 103.51, 160.5 APE8-dihe-in -55.22, 144.8 APE8-rot-in 285.63 APE67-dihe-in -74.86, -38.79 -80.34, -13.24 APE12-dist-in 10.324 APE11-dist-in 11.278 APE10-dist-in 5.647 APE9-dist-in 4.131 None None None XRAY 3.705 0.238 0.269 A 406 393 0 0 0 0 [[76, 338]] 1.0 2v55 AGC_ROCK1_HUMAN AGC 3.3e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 2V55C Q13464 6 404 1354.0 ANP:1480 ATPlike Active DFGin 5.884 13.608 BLAminus -137.56, -177.44 62.15, 108.48 -130.26, 22.71 291.3, 72.92 -54.95, -50.69 in-in in 9.111 Saltbr-in 2.706 HRD-in -78.29, -71.79 95.11, -31.46 in-in-in SNCiii in-in ActLoopNT-in 3.247 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.41, 139.12 APE9-dihe-na 103.28, 159.31 APE8-dihe-in -53.48, 142.5 APE8-rot-in 287.35 APE67-dihe-in -76.24, -37.92 -78.8, -11.99 APE12-dist-in 10.28 APE11-dist-in 11.269 APE10-dist-in 5.623 APE9-dist-in 4.097 None None None XRAY 3.705 0.238 0.269 C 406 396 0 0 0 0 [[76, 338]] 1.0 2v55 AGC_ROCK1_HUMAN AGC 3.3e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC RPS6KA1-1 KS6A1_HUMAN 8XOVA Q15418 56 340 735.0 ANP:401 ATPlike Inactive DFGin 9.532 13.12 BLAplus -128.25, 170.81 61.53, 44.51 -100.37, -14.37 34.15, 82.03 -83.22, -24.55 out-out out 11.134 Saltbr-out 8.897 HRD-in -75.5, -43.57 69.32, -59.52 out-out-out SNCooo out-out ActLoopNT-out 9.509 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioo APE10-dihe-na -98.67, 154.58 APE9-dihe-na -175.48, 178.84 APE8-dihe-in -87.06, 119.03 APE8-rot-in 310.44 APE67-dihe-in -48.48, -27.39 -73.46, -38.49 APE12-dist-none 999.0 APE11-dist-in 10.42 APE10-dist-out 11.512 APE9-dist-out 7.639 None None None XRAY 2.55 0.206 0.252 A 321 261 24 0 0 9 [[62, 321], [418, 675]] 2.0 8xov AGC_RPS6KA1-1_HUMAN AGC 1.5e-95 325.1 1 260 260 204 205 206 208 210 94 112 116 184 186 185 187 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOA P51812 45 348 740.0 ANP:401 ATPlike Inactive DFGin 5.64 11.283 None -75.51, -9.72 -147.12, 169.74 -135.13, 44.64 43.61, 79.33 88.97, 14.8 none-none none 999.0 Saltbr-none 999.0 HRD-in -69.31, -36.27 72.22, -63.18 none-out-out SNCnoo out-out ActLoopNT-out 10.019 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.25 APE8-rot-out 57.51 APE67-dihe-in -58.48, -32.95 -79.53, -17.69 APE12-dist-out 16.181 APE11-dist-out 18.834 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 A 317 295 9 0 0 2 [[68, 327], [422, 679]] 2.0 7opo AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOE P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGin 5.828 11.217 None -75.62, -9.94 -146.57, 168.73 -137.15, 44.22 42.0, 80.75 88.39, 15.03 none-none none 999.0 Saltbr-none 999.0 HRD-in -66.39, -31.42 74.68, -62.95 none-out-out SNCnoo out-out ActLoopNT-out 10.132 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 163.55 APE8-rot-out 177.27 APE67-dihe-in -61.67, -34.26 -80.52, -22.56 APE12-dist-out 16.151 APE11-dist-out 17.693 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 E 317 293 10 0 0 2 [[68, 327], [422, 679]] 2.0 7opo AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOI P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGin 5.742 11.315 None -74.55, -8.16 -143.05, 166.95 -136.59, 41.95 46.16, 81.46 88.21, 13.52 none-none none 999.0 Saltbr-none 999.0 HRD-in -66.43, -31.99 74.45, -63.8 none-out-out SNCnoo out-out ActLoopNT-out 10.224 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_onnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 118.34 APE8-rot-out 174.05 APE67-dihe-in -60.03, -34.02 -108.65, -14.12 APE12-dist-out 16.688 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 I 317 292 11 0 0 3 [[68, 327], [422, 679]] 2.0 7opo AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOK P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGin 5.743 11.055 None -76.12, -10.81 -146.65, 168.53 -136.2, 45.6 41.69, 77.26 88.29, 15.08 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.92, -32.34 73.01, -61.24 none-out-out SNCnoo out-out ActLoopNT-out 9.952 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 7.45 APE8-rot-out 57.97 APE67-dihe-in -59.53, -34.14 -77.79, -20.27 APE12-dist-out 17.117 APE11-dist-out 17.377 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 K 317 293 10 0 0 2 [[68, 327], [422, 679]] 2.0 7opo AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOC P51812 46 347 740.0 ANP:401 ATPlike Inactive DFGinter 5.815 10.993 None -75.13, -10.43 -146.35, 169.25 -135.79, 44.23 43.29, 81.79 87.07, 14.29 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.74, -32.6 74.07, -63.87 none-out-out SNCnoo out-out ActLoopNT-out 10.165 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -61.13, 122.89 APE9-dihe-na 75.62, 166.95 APE8-dihe-in -113.03, 115.92 APE8-rot-out 46.3 APE67-dihe-in -62.7, -36.2 -57.15, -32.55 APE12-dist-out 16.312 APE11-dist-out 16.934 APE10-dist-out 13.494 APE9-dist-out 6.87 None None None XRAY 2.75 0.209 0.232 C 317 295 7 0 0 0 [[68, 327], [422, 679]] 2.0 7opo AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOG P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGinter 6.68 10.963 None -75.68, -10.29 -146.32, 168.68 -137.91, 45.72 44.25, 84.07 86.95, 15.93 out-out out 19.338 Saltbr-out 19.753 HRD-in -66.3, -31.74 74.35, -64.56 out-out-out SNCooo out-out ActLoopNT-out 10.112 ActLoopCT-out nonTYR APEdihe_aanni APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 105.02 APE8-rot-none 999.0 APE67-dihe-in -58.75, -33.49 -86.55, -15.46 APE12-dist-out 16.986 APE11-dist-out 17.767 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 G 317 301 2 0 0 2 [[68, 327], [422, 679]] 2.0 7opo AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA6-1 KS6A6_HUMAN 6G77A Q9UK32 51 349 745.0 ANP:401,ANP:402 Allosteric,ATPlike Inactive DFGin 5.984 11.252 None -84.57, 1.64 -160.36, 173.95 -140.73, 41.08 33.77, 88.9 86.89, 20.77 none-none none 999.0 Saltbr-none 999.0 HRD-in -75.55, -32.96 78.36, -52.1 none-out-out SNCnoo out-out ActLoopNT-out 9.958 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 55.72, -148.34 APE9-dihe-na -103.74, -158.66 APE8-dihe-in -91.11, 113.9 APE8-rot-in 297.76 APE67-dihe-in -53.19, -20.32 -55.54, -41.19 APE12-dist-in 13.732 APE11-dist-out 15.871 APE10-dist-out 13.504 APE9-dist-in 5.532 None None None XRAY 2.499 0.188 0.233 A 307 291 8 0 0 0 [[73, 330], [426, 683]] 2.0 6g77 AGC_RPS6KA6-1_HUMAN AGC 1.1e-97 332.1 1 260 260 215 216 217 219 221 105 123 127 195 197 196 198 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G77B Q9UK32 51 349 745.0 ANP:401,ANP:402 Allosteric,ATPlike Inactive DFGin 5.612 11.311 None -84.74, -2.79 -145.41, 176.89 -143.69, 39.64 45.89, 82.52 94.84, 15.56 none-none none 999.0 Saltbr-none 999.0 HRD-in -77.95, -30.79 74.87, -47.1 none-out-out SNCnoo out-out ActLoopNT-out 10.071 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 55.75, -144.28 APE9-dihe-na -119.2, -153.74 APE8-dihe-in -83.74, 120.03 APE8-rot-in 297.54 APE67-dihe-in -52.98, -34.42 -57.71, -42.71 APE12-dist-in 13.915 APE11-dist-out 16.086 APE10-dist-out 13.633 APE9-dist-in 5.522 None None None XRAY 2.499 0.188 0.233 B 307 291 8 0 0 0 [[73, 330], [426, 683]] 2.0 6g77 AGC_RPS6KA6-1_HUMAN AGC 1.1e-97 332.1 1 260 260 215 216 217 219 221 105 123 127 195 197 196 198 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G76B Q9UK32 51 349 745.0 ANP:401 ATPlike Inactive DFGinter 5.797 10.982 None -66.14, -24.76 -146.8, 171.15 -130.39, 64.5 31.65, 91.02 69.21, 34.12 none-none none 999.0 Saltbr-none 999.0 HRD-in -64.7, -28.83 65.1, -58.97 none-out-none SNCnon out-none ActLoopNT-out 9.714 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -65.75, -19.3 999.0, -17.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP232 SEP232 XRAY 3.0 0.226 0.268 B 307 269 30 0 0 11 [[73, 330], [426, 683]] 2.0 6g76 AGC_RPS6KA6-1_HUMAN AGC 1.1e-97 332.1 1 260 260 215 216 217 219 221 105 123 127 195 197 196 198 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G78A Q9UK32 51 349 745.0 ANP:401 ATPlike Inactive DFGinter 6.269 10.634 None -86.41, -10.47 -141.48, -170.45 -156.88, 52.15 42.27, 88.32 84.48, 16.59 none-none none 999.0 Saltbr-none 999.0 HRD-in -69.26, -28.88 63.94, -61.25 none-out-out SNCnoo out-out ActLoopNT-out 9.59 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 82.23 APE8-dihe-out 57.69, 79.35 APE8-rot-in 324.77 APE67-dihe-in -47.93, -24.91 -65.59, -33.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 7.912 S232E None None XRAY 2.5 0.227 0.24 A 307 283 16 0 0 8 [[73, 330], [426, 683]] 2.0 6g78 AGC_RPS6KA6-1_HUMAN AGC 1.4e-97 331.8 1 260 260 215 216 217 219 221 105 123 127 195 197 196 198 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G78B Q9UK32 51 349 745.0 ANP:401 ATPlike Inactive DFGinter 5.64 10.738 None -79.92, -10.17 -139.49, -179.53 -146.16, 53.91 40.8, 75.5 84.23, 17.04 none-none none 999.0 Saltbr-none 999.0 HRD-in -71.51, -26.87 55.09, -79.87 none-out-out SNCnoo out-out ActLoopNT-out 9.839 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -162.93 APE8-dihe-in -60.6, 118.59 APE8-rot-in 321.37 APE67-dihe-in -66.02, -21.47 -64.56, -33.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.845 S232E None None XRAY 2.5 0.227 0.24 B 307 281 18 0 0 10 [[73, 330], [426, 683]] 2.0 6g78 AGC_RPS6KA6-1_HUMAN AGC 1.4e-97 331.8 1 260 260 215 216 217 219 221 105 123 127 195 197 196 198 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G76A Q9UK32 51 349 745.0 ANP:401,ANP:402 ATPlike,Allosteric Inactive DFGinter 6.261 10.877 None -85.39, -13.66 -143.61, 178.12 -143.21, 50.96 33.86, 88.85 75.03, 27.38 none-none none 999.0 Saltbr-none 999.0 HRD-in -70.26, -5.92 45.43, -59.01 none-out-out SNCnoo out-out ActLoopNT-out 9.842 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 52.64, -135.92 APE9-dihe-na -103.88, -148.96 APE8-dihe-in -100.12, 127.8 APE8-rot-in 306.8 APE67-dihe-in -56.57, -28.02 -70.04, -37.97 APE12-dist-in 13.909 APE11-dist-out 16.247 APE10-dist-out 12.746 APE9-dist-in 5.596 None SEP232 SEP232 XRAY 3.0 0.226 0.268 A 307 291 8 0 0 0 [[73, 330], [426, 683]] 2.0 6g76 AGC_RPS6KA6-1_HUMAN AGC 1.1e-97 332.1 1 260 260 215 216 217 219 221 105 123 127 195 197 196 198 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC SGK1 SGK1_HUMAN 2R5TA O00141 82 378 431.0 ANP:500 ATPlike Inactive DFGinter 10.249 5.74 None -86.79, -16.14 -72.2, 135.26 -125.95, 20.0 58.26, 94.07 102.37, 6.12 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.44, -44.78 83.3, -51.0 none-out-out SNCnoo out-out ActLoopNT-out 9.243 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na 54.74, 50.94 APE9-dihe-na -69.27, 152.13 APE8-dihe-in -51.76, 128.99 APE8-rot-in 305.39 APE67-dihe-out -166.98, 160.95 -53.6, 132.16 APE12-dist-out 29.883 APE11-dist-out 30.65 APE10-dist-out 28.034 APE9-dist-out 16.248 S74A,S78A,S397A,S401A None None XRAY 1.9 0.193 0.215 A 373 284 13 0 0 0 [[98, 355]] 1.0 2r5t AGC_SGK1_HUMAN AGC 4.6e-99 336.7 1 260 260 239 240 241 243 245 127 146 150 219 221 220 222 279 267 262 261 260 259 258 257 256 177 Serine/threonine-protein kinase Sgk1
AGC STK38 STK38_HUMAN 6BXIA Q15208 82 414 465.0 ANP:501 ATPlike Inactive DFGin 7.624 15.242 None -66.11, 165.54 -58.06, 132.91 -140.43, 160.91 66.01, 93.84 127.58, -39.07 out-out out 17.224 Saltbr-out 15.803 HRD-out -81.74, 95.52 -90.45, 26.47 out-out-out SNCooo out-out ActLoopNT-out 8.463 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -99.6, -60.62 APE9-dihe-na 67.05, -156.06 APE8-dihe-in -145.17, 163.6 APE8-rot-out 65.89 APE67-dihe-in -50.28, -35.19 -91.75, 25.88 APE12-dist-out 17.338 APE11-dist-out 14.208 APE10-dist-out 17.77 APE9-dist-out 12.101 None None None XRAY 2.2 0.173 0.212 A 333 333 0 0 0 0 [[89, 382]] 1.0 6bxi AGC_STK38_HUMAN AGC 2.8e-98 334.1 1 260 260 229 230 231 233 235 118 137 141 209 211 210 212 304 292 287 286 285 284 283 282 281 167 Serine/threonine-protein kinase 38
AGC STK38 STK38_HUMAN 6BXIB Q15208 83 414 465.0 ANP:501 ATPlike Inactive DFGin 7.583 15.179 None -72.08, 165.13 -53.35, 130.13 -138.87, 159.98 66.77, 96.29 126.01, -39.3 out-out out 17.166 Saltbr-out 16.064 HRD-out -84.3, 107.68 -100.32, 27.31 out-out-out SNCooo out-out ActLoopNT-out 8.488 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -97.07, -63.08 APE9-dihe-na 73.07, -157.98 APE8-dihe-in -144.12, 160.82 APE8-rot-out 65.98 APE67-dihe-in -53.15, -35.39 -88.29, 27.93 APE12-dist-out 17.239 APE11-dist-out 14.184 APE10-dist-out 17.741 APE9-dist-out 12.052 None None None XRAY 2.2 0.173 0.212 B 333 332 0 0 0 0 [[89, 382]] 1.0 6bxi AGC_STK38_HUMAN AGC 2.8e-98 334.1 1 260 260 229 230 231 233 235 118 137 141 209 211 210 212 304 292 287 286 285 284 283 282 281 167 Serine/threonine-protein kinase 38
CAMK AURKA AURKA_HUMAN 2DWBA O14965 126 389 403.0 ANP:502 ATPlike Inactive DFGin 5.605 15.114 BLAminus -136.11, 177.41 60.85, 78.38 -89.15, 29.26 286.88, 68.88 -66.25, -4.03 in-in in 9.24 Saltbr-in 3.169 HRD-in -70.6, -46.07 60.68, 4.1 in-in-out SNCiio in-out ActLoopNT-in 3.036 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -134.99, -178.03 APE9-dihe-na -132.27, -116.26 APE8-dihe-in -79.37, 134.9 APE8-rot-out 179.73 APE67-dihe-in -26.2, -44.84 -85.0, -15.78 APE12-dist-in 8.036 APE11-dist-in 12.139 APE10-dist-out 11.162 APE9-dist-out 10.827 None None MSE300,MSE305,MSE373 XRAY 2.5 0.227 0.275 A 285 262 2 0 0 2 [[133, 383]] 1.0 2dwb CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPGA O14965 7 389 403.0 ANP:60401 ATPlike Active DFGin 5.318 15.07 BLAminus -133.54, 176.05 56.91, 81.54 -90.61, 23.9 286.39, 75.22 -62.73, -9.76 in-in in 9.884 Saltbr-in 2.954 HRD-in -72.51, -51.0 67.55, 11.3 in-in-in SNCiii in-in ActLoopNT-in 3.043 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.96, 159.16 APE9-dihe-na 122.67, -152.53 APE8-dihe-in -117.94, 146.39 APE8-rot-in 309.68 APE67-dihe-in -61.83, -12.97 -52.19, -62.88 APE12-dist-in 8.517 APE11-dist-in 11.427 APE10-dist-in 5.724 APE9-dist-in 3.833 None TPO287,TPO288 TPO287,TPO288 XRAY 2.64 0.204 0.245 A 292 267 0 0 0 0 [[133, 383]] 1.0 6vpg CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPIA O14965 104 389 403.0 ANP:60601 ATPlike Inactive DFGin 5.408 15.319 BLAminus -130.78, 176.39 58.02, 80.51 -93.54, 25.65 284.58, 75.71 -64.44, -24.62 in-in in 9.884 Saltbr-in 3.197 HRD-in -68.95, -50.99 70.99, 3.21 in-in-out SNCiio in-out ActLoopNT-in 2.821 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -142.04, 146.83 APE9-dihe-na 91.87, 167.2 APE8-dihe-in -74.18, 122.94 APE8-rot-in 319.25 APE67-dihe-in -55.59, -26.7 -100.93, -9.45 APE12-dist-in 10.01 APE11-dist-in 12.835 APE10-dist-out 16.149 APE9-dist-out 20.056 None None None XRAY 2.0 0.188 0.215 A 292 264 0 0 0 0 [[133, 383]] 1.0 6vpi CAMK_AURKA_HUMAN CAMK 6.9e-78 267.5 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPLA O14965 7 389 403.0 ANP:60602,R7D:60606 ATPlike,Allosteric Inactive DFGin 5.471 15.702 BLAminus -128.47, 179.47 64.6, 81.81 -95.02, 21.48 283.88, 78.68 -63.38, -17.61 out-out out 10.41 Saltbr-out 4.499 HRD-in -80.46, -54.34 74.63, 5.06 out-in-out SNCoio in-out ActLoopNT-in 2.966 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -88.44, -6.25 APE9-dihe-na -62.06, -23.8 APE8-dihe-in -134.19, 108.37 APE8-rot-in 311.29 APE67-dihe-in -61.89, -28.27 -86.38, -9.29 APE12-dist-out 25.894 APE11-dist-out 21.325 APE10-dist-out 23.16 APE9-dist-out 28.004 None TPO288 TPO288 XRAY 1.86 0.169 0.201 A 292 261 4 0 0 4 [[133, 383]] 1.0 6vpl CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPLB O14965 7 389 403.0 ANP:60601,R7D:60605 ATPlike,Allosteric Inactive DFGin 5.583 16.045 BLAminus -127.84, 176.75 65.51, 80.18 -93.8, 23.88 286.09, 77.69 -67.93, -15.19 out-out out 10.656 Saltbr-out 4.558 HRD-in -79.97, -52.06 71.02, 4.97 out-in-out SNCoio in-out ActLoopNT-in 2.944 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -84.27, -7.56 APE9-dihe-na -59.65, -24.89 APE8-dihe-in -135.15, 99.87 APE8-rot-in 315.26 APE67-dihe-in -58.26, -30.91 -76.18, -13.07 APE12-dist-out 25.859 APE11-dist-out 21.401 APE10-dist-out 23.563 APE9-dist-out 28.245 None TPO288 TPO288 XRAY 1.86 0.169 0.201 B 292 261 4 0 0 4 [[133, 383]] 1.0 6vpl CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2C6DA O14965 126 390 403.0 ANP:61391 ATPlike Inactive DFGin 6.257 16.422 None -70.12, 150.14 -40.51, 101.21 -55.1, 131.85 61.77, 102.87 98.63, -164.78 out-out out 13.16 Saltbr-out 13.998 HRD-out -91.98, 166.93 -128.47, 87.17 out-out-out SNCooo out-out ActLoopNT-out 17.933 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 134.8 APE8-dihe-in -71.63, 167.98 APE8-rot-out 60.54 APE67-dihe-in -57.74, -18.95 -51.64, -36.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.044 None None None XRAY 2.2 0.23 0.28 A 275 255 10 0 0 10 [[133, 383]] 1.0 2c6d CAMK_AURKA_HUMAN CAMK 1.5e-79 272.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPJA O14965 104 389 403.0 ANP:60401 ATPlike Inactive DFGout 12.87 10.574 None -110.21, 156.22 -91.65, 36.01 -66.52, 152.83 298.69, 154.8 77.13, 20.04 out-out out 11.11 Saltbr-out 9.286 HRD-out -138.11, 171.42 -106.7, -171.48 out-out-out SNCooo out-out ActLoopNT-out 12.659 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -97.02, 1.42 APE9-dihe-na 78.4, 140.83 APE8-dihe-out -96.06, -166.39 APE8-rot-out 60.44 APE67-dihe-in -59.33, -27.82 -96.84, 6.17 APE12-dist-in 11.648 APE11-dist-in 13.256 APE10-dist-out 10.911 APE9-dist-out 17.215 None None None XRAY 2.1 0.192 0.215 A 292 263 3 0 0 3 [[133, 383]] 1.0 6vpj CAMK_AURKA_HUMAN CAMK 7.7e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPHA O14965 7 389 403.0 ANP:60604 ATPlike Inactive DFGout 13.671 11.556 None -98.71, -169.93 -135.39, 50.18 -66.9, 153.36 295.81, 141.3 65.48, 29.39 out-out out 11.379 Saltbr-out 9.775 HRD-out -105.53, 132.54 -112.81, 142.85 out-out-out SNCooo out-out ActLoopNT-out 14.58 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na -129.35, -34.6 APE9-dihe-na -51.22, -37.08 APE8-dihe-out -65.53, -18.81 APE8-rot-out 65.19 APE67-dihe-in -56.69, -28.96 -65.95, -34.72 APE12-dist-out 14.76 APE11-dist-in 9.582 APE10-dist-out 12.257 APE9-dist-out 21.222 None TPO287,TPO288 CAS247,TPO287,TPO288,CAS290 XRAY 2.14 0.189 0.216 A 292 267 0 0 0 0 [[133, 383]] 1.0 6vph CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK CASK CSKP_HUMAN 3MFRA O14936 5 306 926.0 ANP:500 ATPlike Pseudo DFGin 7.288 14.824 BLAminus -130.01, -163.55 44.45, 79.28 -92.76, 26.16 280.97, 75.37 -59.27, -25.64 in-in in 9.502 Saltbr-in 2.799 HRD-in -78.83, -45.71 73.64, -1.18 in-in-in SNCiii in-in ActLoopNT-in 2.998 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.41, 141.74 APE9-dihe-na 116.11, -155.43 APE8-dihe-in -114.21, 120.95 APE8-rot-in 305.84 APE67-dihe-in -66.35, -20.44 -39.68, -44.71 APE12-dist-in 11.987 APE11-dist-in 12.403 APE10-dist-in 6.658 APE9-dist-in 3.593 P22A,H145E,C146N,G162D None None XRAY 2.0 0.198 0.241 A 351 302 0 0 0 0 [[12, 276]] 1.0 3mfr CAMK_CASK_HUMAN CAMK 2.4e-85 291.9 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3MFSA O14936 4 306 926.0 ANP:500 ATPlike Pseudo DFGin 7.121 14.917 BLAminus -132.54, -159.47 54.72, 71.28 -90.49, 27.88 285.64, 73.35 -63.01, -24.88 in-in in 9.855 Saltbr-in 3.256 HRD-in -74.69, -45.24 69.87, -1.37 in-in-in SNCiii in-in ActLoopNT-in 2.876 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.15, 142.33 APE9-dihe-na 119.56, -149.24 APE8-dihe-in -110.99, 115.07 APE8-rot-in 303.42 APE67-dihe-in -55.02, -32.56 -38.77, -44.89 APE12-dist-in 12.085 APE11-dist-in 12.3 APE10-dist-in 6.637 APE9-dist-in 3.634 P22A,H145E,C146N,G162D None None XRAY 2.1 0.221 0.268 A 351 303 0 0 0 0 [[12, 276]] 1.0 3mfs CAMK_CASK_HUMAN CAMK 2.4e-85 291.9 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3MFUA O14936 5 306 926.0 ANP:500 ATPlike Pseudo DFGin 7.162 14.979 BLAminus -132.46, -169.21 51.97, 75.16 -95.02, 30.45 283.47, 72.96 -64.45, -32.11 in-in in 9.439 Saltbr-in 3.206 HRD-in -76.17, -45.52 71.72, -5.88 in-in-in SNCiii in-in ActLoopNT-in 2.823 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.79, 142.93 APE9-dihe-na 117.49, -160.73 APE8-dihe-in -102.18, 121.4 APE8-rot-in 298.46 APE67-dihe-in -63.89, -19.89 -44.81, -44.73 APE12-dist-in 12.084 APE11-dist-in 12.195 APE10-dist-in 6.449 APE9-dist-in 3.737 P22A,H145E,C146N,G162D None None XRAY 2.3 0.182 0.234 A 351 302 0 0 0 0 [[12, 276]] 1.0 3mfu CAMK_CASK_HUMAN CAMK 2.4e-85 291.9 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 9M6GA O14936 5 312 926.0 ANP:401 ATPlike Pseudo DFGin 7.452 15.114 BLAminus -123.77, -152.06 75.54, 37.97 -87.68, 22.87 280.47, 84.05 -71.57, -12.61 in-in in 9.6 Saltbr-in 2.897 HRD-in -79.25, -45.64 76.25, -8.72 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.23, 151.66 APE9-dihe-na 106.36, -155.68 APE8-dihe-in -120.97, 120.76 APE8-rot-in 297.98 APE67-dihe-in -62.79, -20.16 -47.6, -44.68 APE12-dist-in 12.42 APE11-dist-in 12.215 APE10-dist-in 6.65 APE9-dist-in 3.645 None None None XRAY 1.7 0.167 0.187 A 325 308 0 0 0 0 [[12, 276]] 1.0 9m6g CAMK_CASK_HUMAN CAMK 4.9e-82 281.1 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 9M5YA O14936 3 312 926.0 ANP:401 ATPlike Pseudo DFGin 7.714 15.512 BLAminus -121.67, -150.51 71.79, 35.46 -86.15, 22.59 279.83, 82.24 -67.65, -16.3 in-in in 9.959 Saltbr-in 2.867 HRD-in -79.78, -48.63 75.37, -2.97 in-in-in SNCiii in-in ActLoopNT-in 3.012 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.65, 147.9 APE9-dihe-na 109.7, -155.33 APE8-dihe-in -121.16, 120.88 APE8-rot-in 298.99 APE67-dihe-in -58.84, -21.41 -46.45, -46.8 APE12-dist-in 12.687 APE11-dist-in 12.279 APE10-dist-in 6.857 APE9-dist-in 3.592 None None None XRAY 1.8 0.168 0.197 A 338 310 0 0 0 0 [[12, 276]] 1.0 9m5y CAMK_CASK_HUMAN CAMK 5.6e-82 280.9 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CHEK1 CHK1_HUMAN 5OOPA O14757 5 271 476.0 ANP:301 ATPlike Inactive DFGin 7.048 13.858 BLAminus -117.87, 168.06 78.81, 84.96 -99.9, 22.77 292.72, 82.66 -69.65, -23.48 in-out in 9.592 Saltbr-out 3.669 HRD-in -77.29, -47.33 77.92, -0.19 out-in-in SNCoii in-in ActLoopNT-in 2.894 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.46, 169.24 APE9-dihe-na 115.98, -146.93 APE8-dihe-in -135.24, 119.66 APE8-rot-in 302.63 APE67-dihe-in -65.46, -19.69 -46.47, -46.68 APE12-dist-in 8.889 APE11-dist-in 11.835 APE10-dist-in 6.194 APE9-dist-in 3.474 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.7 0.159 0.197 A 297 261 6 0 0 0 [[9, 265]] 1.0 5oop CAMK_CHEK1_HUMAN CAMK 4.8e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK DAPK1 DAPK1_HUMAN 1IG1A P53355 2 294 1430.0 ANP:300 ATPlike Inactive DFGin 6.604 13.909 BLAminus -125.04, -172.1 54.91, 85.1 -99.27, 28.4 288.12, 76.24 -63.74, -23.2 in-in in 9.031 Saltbr-in 2.75 HRD-in -78.58, -44.7 65.96, 3.14 in-in-out SNCiio in-out ActLoopNT-in 2.921 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -151.68, 130.77 APE9-dihe-na -110.11, -140.22 APE8-dihe-in -82.02, 119.3 APE8-rot-in 301.63 APE67-dihe-in -57.96, -29.17 -38.12, -46.81 APE12-dist-in 11.797 APE11-dist-out 6.564 APE10-dist-out 9.413 APE9-dist-in 4.736 None None None XRAY 1.8 0.19 0.213 A 294 280 0 0 0 0 [[13, 275]] 1.0 1ig1 CAMK_DAPK1_HUMAN CAMK 6.1e-95 323.3 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 1JKKA P53355 2 293 1430.0 ANP:300 ATPlike Inactive DFGin 6.784 14.124 BLAminus -129.05, -171.64 53.69, 79.96 -93.76, 28.82 285.99, 76.67 -62.99, -25.8 in-in in 9.083 Saltbr-in 2.852 HRD-in -75.07, -48.19 66.55, 3.19 in-in-out SNCiio in-out ActLoopNT-in 2.818 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -147.0, 130.95 APE9-dihe-na -112.64, -140.24 APE8-dihe-in -81.46, 116.94 APE8-rot-in 307.06 APE67-dihe-in -60.31, -32.99 -34.91, -46.77 APE12-dist-in 11.783 APE11-dist-out 6.58 APE10-dist-out 9.463 APE9-dist-in 4.776 None None None XRAY 2.4 0.204 0.239 A 294 277 0 0 0 0 [[13, 275]] 1.0 1jkk CAMK_DAPK1_HUMAN CAMK 6.1e-95 323.3 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 1JKLA P53355 2 294 1430.0 ANP:300 ATPlike Inactive DFGin 6.695 14.057 BLAminus -124.2, -176.99 56.35, 84.0 -97.94, 28.61 287.61, 72.21 -64.45, -19.09 in-in in 9.138 Saltbr-in 2.734 HRD-in -79.78, -44.18 66.54, 4.23 in-in-out SNCiio in-out ActLoopNT-in 2.905 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -149.57, 122.41 APE9-dihe-na -98.92, -146.89 APE8-dihe-in -78.98, 121.07 APE8-rot-in 305.85 APE67-dihe-in -59.69, -24.46 -37.84, -49.7 APE12-dist-in 11.685 APE11-dist-out 6.593 APE10-dist-out 9.371 APE9-dist-in 4.342 None None None XRAY 1.62 0.201 0.218 A 294 280 0 0 0 0 [[13, 275]] 1.0 1jkl CAMK_DAPK1_HUMAN CAMK 6.1e-95 323.3 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3EHAA P53355 2 277 1430.0 ANP:60001 ATPlike Inactive DFGin 6.643 13.968 BLAminus -119.49, -175.62 63.64, 76.35 -92.04, 24.1 287.15, 77.48 -66.02, -21.06 in-in in 9.158 Saltbr-in 2.692 HRD-in -77.77, -44.22 68.16, 6.09 in-in-out SNCiio in-out ActLoopNT-in 2.888 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -154.08, 109.66 APE9-dihe-na -88.11, -145.31 APE8-dihe-in -81.75, 125.02 APE8-rot-in 299.42 APE67-dihe-in -58.59, -25.21 -48.84, -41.78 APE12-dist-in 11.47 APE11-dist-out 6.085 APE10-dist-out 9.287 APE9-dist-in 4.222 None None None XRAY 1.6 0.18 0.21 A 294 275 1 0 0 0 [[13, 275]] 1.0 3eha CAMK_DAPK1_HUMAN CAMK 6.1e-95 323.3 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3F5UA P53355 2 277 1430.0 ANP:60296 ATPlike Inactive DFGin 6.68 13.995 BLAminus -122.58, -175.66 63.1, 76.98 -89.92, 20.62 285.03, 75.31 -66.71, -20.92 in-in in 9.054 Saltbr-in 2.688 HRD-in -78.22, -44.99 68.31, 7.38 in-in-out SNCiio in-out ActLoopNT-in 2.898 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -161.85, 115.62 APE9-dihe-na -94.87, -137.37 APE8-dihe-in -88.11, 123.84 APE8-rot-in 295.48 APE67-dihe-in -54.81, -31.05 -45.75, -45.06 APE12-dist-in 11.55 APE11-dist-out 6.151 APE10-dist-out 9.358 APE9-dist-in 4.63 None None None XRAY 2.0 0.18 0.245 A 295 276 0 0 0 0 [[13, 275]] 1.0 3f5u CAMK_DAPK1_HUMAN CAMK 6.2e-95 323.3 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3DFCB P53355 2 277 1430.0 ANP:60296 ATPlike Inactive DFGin 6.707 13.953 BLAminus -118.29, -174.34 63.43, 75.59 -92.23, 26.78 286.33, 80.12 -73.39, -15.17 in-in in 8.97 Saltbr-in 2.527 HRD-in -81.02, -45.28 68.61, 4.35 in-in-out SNCiio in-out ActLoopNT-in 2.938 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -159.6, 115.29 APE9-dihe-na -93.8, -150.98 APE8-dihe-in -71.52, 120.43 APE8-rot-in 314.5 APE67-dihe-in -56.35, -28.25 -48.91, -39.24 APE12-dist-in 10.0 APE11-dist-out 6.581 APE10-dist-out 9.299 APE9-dist-in 4.232 Q23K None None XRAY 1.9 0.168 0.23 B 295 276 0 0 0 0 [[13, 275]] 1.0 3dfc CAMK_DAPK1_HUMAN CAMK 6.8e-95 323.2 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3GU4A P53355 2 277 1430.0 ANP:60296 ATPlike Inactive DFGin 6.686 14.203 BLAminus -120.75, -178.24 63.74, 79.48 -95.12, 25.33 287.4, 76.71 -69.42, -15.77 in-in in 9.154 Saltbr-in 2.755 HRD-in -78.17, -46.9 70.13, 2.93 in-in-out SNCiio in-out ActLoopNT-in 2.893 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -151.92, 117.7 APE9-dihe-na -90.42, -152.95 APE8-dihe-in -78.93, 125.78 APE8-rot-in 285.84 APE67-dihe-in -58.94, -26.13 -43.12, -44.76 APE12-dist-in 9.916 APE11-dist-out 6.699 APE10-dist-out 9.394 APE9-dist-in 4.146 Q23V None None XRAY 1.35 0.185 0.211 A 295 276 0 0 0 0 [[13, 275]] 1.0 3gu4 CAMK_DAPK1_HUMAN CAMK 2.1e-94 321.5 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3GU5A P53355 2 277 1430.0 ANP:60297 ATPlike Inactive DFGin 6.595 14.036 BLAminus -118.63, -175.92 62.35, 83.7 -99.02, 25.46 285.84, 80.17 -66.36, -22.17 in-in in 9.075 Saltbr-in 2.707 HRD-in -79.55, -44.61 67.36, 6.25 in-in-out SNCiio in-out ActLoopNT-in 2.938 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -153.43, 114.75 APE9-dihe-na -95.21, -137.89 APE8-dihe-in -89.62, 125.79 APE8-rot-in 297.58 APE67-dihe-in -53.19, -29.37 -44.73, -43.47 APE12-dist-in 11.313 APE11-dist-out 6.28 APE10-dist-out 9.572 APE9-dist-in 4.755 Q23V None None XRAY 1.65 0.178 0.219 A 295 276 0 0 0 0 [[13, 275]] 1.0 3gu5 CAMK_DAPK1_HUMAN CAMK 2.1e-94 321.5 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK MELK MELK_HUMAN 4BL1A Q14680 2 333 651.0 ANP:1000 ATPlike Inactive DFGin 6.338 13.935 ABAminus -114.35, -16.21 -125.02, 95.86 -105.85, 20.97 306.05, 72.32 -48.23, -28.35 in-in in 8.566 Saltbr-in 2.628 HRD-in -47.49, -61.71 83.33, 5.93 in-in-out SNCiio in-out ActLoopNT-in 3.099 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 125.09 APE8-rot-out 166.93 APE67-dihe-in -51.79, -28.37 -37.56, -42.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.184 0.26 A 347 312 20 0 0 14 [[11, 263]] 1.0 4bl1 CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK PIM1 PIM1_HUMAN 1YXTA P11309 33 306 313.0 ANP:322 ATPlike Active DFGin 6.029 14.245 BLAminus -131.81, 176.98 66.39, 83.69 -99.64, 19.64 287.53, 80.25 -65.72, -15.35 in-in in 8.309 Saltbr-in 2.894 HRD-na-A -67.95, -50.18 66.45, 4.68 in-in-in SNCiii in-in ActLoopNT-in 2.809 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.69, 12.99 APE9-dihe-na -80.03, -158.46 APE8-dihe-in -83.46, 121.7 APE8-rot-in 308.53 APE67-dihe-in -70.36, -3.81 -49.69, -52.76 APE12-dist-in 9.729 APE11-dist-in 8.665 APE10-dist-in 5.279 APE9-dist-in 3.805 None None None XRAY 2.0 0.183 0.216 A 293 274 0 0 0 0 [[38, 290]] 1.0 1yxt CAMK_PIM1_HUMAN CAMK 3.2e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 1XR1A P11309 32 308 313.0 ANP:501 ATPlike Active DFGin 5.888 14.214 BLAminus -138.05, 176.98 59.78, 85.31 -96.55, 16.88 287.93, 82.19 -61.38, -7.19 in-in in 8.717 Saltbr-in 2.833 HRD-na-A -59.95, -51.82 71.23, 5.72 in-in-in SNCiii in-in ActLoopNT-in 2.752 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.05, 45.66 APE9-dihe-na -114.17, -171.15 APE8-dihe-in -64.11, 112.97 APE8-rot-in 299.41 APE67-dihe-in -49.28, -12.21 -42.84, -67.53 APE12-dist-in 9.608 APE11-dist-in 8.695 APE10-dist-in 5.522 APE9-dist-in 4.07 None None None XRAY 2.1 0.267 0.301 A 300 277 0 0 0 0 [[38, 290]] 1.0 1xr1 CAMK_PIM1_HUMAN CAMK 3.4e-65 225.8 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3A99A P11309 33 305 313.0 ANP:501 ATPlike Active DFGin 5.934 14.254 BLAminus -128.38, 171.59 60.85, 87.29 -96.61, 22.08 288.57, 75.78 -65.84, -9.23 in-in in 8.754 Saltbr-in 2.604 HRD-na-A -66.86, -47.45 66.12, 8.26 in-in-in SNCiii in-in ActLoopNT-in 2.889 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.19, 26.41 APE9-dihe-na -87.51, -159.07 APE8-dihe-in -85.64, 119.66 APE8-rot-in 305.41 APE67-dihe-in -70.7, -5.81 -56.65, -39.81 APE12-dist-in 9.612 APE11-dist-in 8.461 APE10-dist-in 5.29 APE9-dist-in 3.778 None None None XRAY 1.6 0.187 0.206 A 320 273 0 0 0 0 [[38, 290]] 1.0 3a99 CAMK_PIM1_HUMAN CAMK 4.3e-65 225.5 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 2BZKB P11309 33 305 313.0 ANP:1306 ATPlike Active DFGin 6.126 14.443 BLAminus -123.86, 174.78 64.57, 79.13 -87.5, 17.23 286.98, 86.61 -67.5, -17.62 in-in in 8.781 Saltbr-in 2.727 HRD-na-A -70.49, -48.81 68.36, 6.4 in-in-in SNCiii in-in ActLoopNT-in 2.813 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.63, 10.91 APE9-dihe-na -77.79, -156.22 APE8-dihe-in -90.85, 124.06 APE8-rot-in 315.85 APE67-dihe-in -68.94, -10.63 -60.69, -42.64 APE12-dist-in 9.464 APE11-dist-in 8.478 APE10-dist-in 4.851 APE9-dist-in 3.782 R250G None None XRAY 2.45 0.191 0.225 B 313 268 5 0 0 0 [[38, 290]] 1.0 2bzk CAMK_PIM1_HUMAN CAMK 1.5e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PLK1 PLK1_HUMAN 8X72A P53350 37 330 603.0 ANP:401 ATPlike Inactive DFGin 5.674 14.562 BLAminus -124.66, -175.79 56.01, 84.34 -93.5, 28.11 290.48, 83.55 -67.08, -22.62 out-in out 10.036 Saltbr-in 3.369 HRD-in -69.02, -52.36 73.21, 2.03 in-in-out SNCiio in-out ActLoopNT-in 2.995 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -79.36, 95.87 APE9-dihe-na 140.51, 168.33 APE8-dihe-in -120.38, 96.0 APE8-rot-in 313.63 APE67-dihe-out -71.46, -55.88 -64.61, 149.56 APE12-dist-in 10.85 APE11-dist-out 7.455 APE10-dist-in 7.653 APE9-dist-out 8.043 None None None XRAY 2.2 0.198 0.25 A 333 294 0 0 0 0 [[53, 305]] 1.0 8x72 CAMK_PLK1_HUMAN CAMK 1.7e-78 269.4 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
CAMK PLK1 PLK1_HUMAN 2OU7A P53350 37 328 603.0 ANP:500 ATPlike Inactive DFGin 5.511 14.626 BLAminus -126.46, 177.9 64.03, 83.89 -94.43, 31.27 293.9, 81.92 -69.65, -29.63 out-in out 10.018 Saltbr-in 3.599 HRD-in -73.43, -50.53 79.22, -6.25 in-in-out SNCiio in-out ActLoopNT-in 2.959 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -86.17, 94.2 APE9-dihe-na 146.34, 174.25 APE8-dihe-in -131.14, 97.57 APE8-rot-in 299.54 APE67-dihe-out -68.04, -58.6 -56.03, 146.92 APE12-dist-in 10.381 APE11-dist-out 7.186 APE10-dist-in 7.436 APE9-dist-out 8.241 T210V None None XRAY 2.4 0.205 0.235 A 335 292 0 0 0 0 [[53, 305]] 1.0 2ou7 CAMK_PLK1_HUMAN CAMK 1.8e-78 269.4 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
CAMK PLK4 PLK4_HUMAN 3COKA O00444 2 266 970.0 ANP:60301 ATPlike Inactive DFGin 6.144 15.397 BLAminus -124.31, 169.68 62.14, 91.45 -100.82, 17.44 292.06, 88.73 -56.38, -36.52 in-out in 9.768 Saltbr-out 4.569 HRD-out -88.33, 122.35 -44.77, 114.93 out-in-none SNCoin in-none ActLoopNT-in 2.788 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.25 0.211 0.261 A 278 232 33 0 0 19 [[12, 265]] 1.0 3cok CAMK_PLK4_HUMAN CAMK 4.8e-82 281.0 1 256 256 153 154 155 157 159 41 60 64 133 135 134 136 193 181 176 175 174 173 172 171 170 90 Serine/threonine-protein kinase PLK4
CAMK PLK4 PLK4_HUMAN 3COKB O00444 2 266 970.0 ANP:60301 ATPlike Inactive DFGin 5.915 15.333 BLAminus -133.97, 164.53 62.63, 97.48 -104.66, 14.21 301.0, 88.72 -54.53, -38.93 in-out in 9.804 Saltbr-out 7.178 HRD-out -90.24, 129.56 -55.53, 110.17 out-in-none SNCoin in-none ActLoopNT-in 2.834 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.25 0.211 0.261 B 278 232 33 0 0 19 [[12, 265]] 1.0 3cok CAMK_PLK4_HUMAN CAMK 4.8e-82 281.0 1 256 256 153 154 155 157 159 41 60 64 133 135 134 136 193 181 176 175 174 173 172 171 170 90 Serine/threonine-protein kinase PLK4
CAMK RPS6KA5-2 KS6A5_HUMAN 3KN5A O75582 415 729 802.0 ANP:400 ATPlike None DFGin 5.469 14.143 BLAminus -120.9, 173.77 65.89, 86.51 -96.46, 22.04 287.59, 69.84 -51.57, -39.89 in-in in 8.867 Saltbr-in 2.809 HRD-in -86.24, -52.51 73.21, 10.94 in-in-none SNCiin in-none ActLoopNT-in 2.989 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.211 0.278 A 325 282 33 0 0 18 [[49, 318], [423, 687]] 2.0 3kn5 CAMK_RPS6KA5-2_HUMAN CAMK 2.1e-87 298.7 5 256 252 564 565 566 568 570 455 468 472 541 543 542 544 604 592 587 586 585 584 583 582 581 499 Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA5-2 KS6A5_HUMAN 3KN5B O75582 415 729 802.0 ANP:400 ATPlike None DFGin 5.769 14.211 BLAminus -127.01, 177.83 61.12, 80.37 -96.03, 24.29 287.04, 69.05 -65.01, -20.75 in-in in 8.872 Saltbr-in 2.738 HRD-in -80.02, -49.37 72.67, 1.66 in-in-none SNCiin in-none ActLoopNT-in 2.867 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.211 0.278 B 325 289 26 0 0 18 [[49, 318], [423, 687]] 2.0 3kn5 CAMK_RPS6KA5-2_HUMAN CAMK 2.1e-87 298.7 5 256 252 564 565 566 568 570 455 468 472 541 543 542 544 604 592 587 586 585 584 583 582 581 499 Ribosomal protein S6 kinase alpha-5
CAMK STK11 STK11_HUMAN 2WTKC Q15831 47 342 433.0 ANP:2 ATPlike Active DFGin 6.192 13.745 BLAminus -119.65, -175.81 55.97, 66.27 -90.3, 25.87 311.18, 25.77 -80.53, -8.11 in-in in 9.443 Saltbr-in 3.361 HRD-in -68.47, -42.92 70.9, -7.9 in-in-in SNCiii in-in ActLoopNT-in 2.648 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na 69.85, 15.07 APE9-dihe-na -72.04, -171.91 APE8-dihe-in -90.01, 115.78 APE8-rot-in 306.68 APE67-dihe-in -55.63, -13.05 -36.08, -60.58 APE12-dist-in 7.784 APE11-dist-in 9.233 APE10-dist-in 5.395 APE9-dist-in 3.173 D194A None None XRAY 2.65 0.24 0.291 C 305 285 3 0 0 0 [[49, 309]] 1.0 2wtk CAMK_STK11_HUMAN CAMK 7.7e-66 228.0 1 256 256 193 194 195 197 199 78 98 102 173 175 174 176 237 223 218 217 216 215 214 213 212 130 Serine/threonine-protein kinase STK11
CAMK STK11 STK11_HUMAN 2WTKF Q15831 45 340 433.0 ANP:4 ATPlike Active DFGin 5.938 13.841 BLAminus -119.11, -173.26 54.53, 62.76 -80.33, 19.16 295.83, 69.09 -48.31, -46.43 in-in in 9.483 Saltbr-in 3.568 HRD-in -68.65, -42.45 72.6, -14.65 in-in-in SNCiii in-in ActLoopNT-in 2.922 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na 45.91, 2.58 APE9-dihe-na -73.83, 178.68 APE8-dihe-in -66.98, 134.68 APE8-rot-in 293.57 APE67-dihe-in -65.1, -33.79 -54.08, -45.39 APE12-dist-in 8.609 APE11-dist-in 9.659 APE10-dist-in 5.793 APE9-dist-in 3.313 D194A None None XRAY 2.65 0.24 0.291 F 305 268 16 0 0 0 [[49, 309]] 1.0 2wtk CAMK_STK11_HUMAN CAMK 7.7e-66 228.0 1 256 256 193 194 195 197 199 78 98 102 173 175 174 176 237 223 218 217 216 215 214 213 212 130 Serine/threonine-protein kinase STK11
CK1 VRK1 VRK1_HUMAN 6AC9A Q99986 21 342 396.0 ANP:401 ATPlike Inactive DFGin 7.921 14.706 BLAminus -114.21, 177.93 70.15, 93.84 -115.1, 19.79 299.42, 81.98 -60.26, -28.75 in-in in 7.95 Saltbr-in 2.779 HRD-in -85.24, -47.15 69.74, 5.52 in-in-out SNCiio in-out ActLoopNT-in 2.799 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -132.17, 15.24 APE9-dihe-na 79.52, -153.87 APE8-dihe-in -97.68, 119.65 APE8-rot-in 299.88 APE67-dihe-in -62.87, -27.26 -44.77, -50.87 APE12-dist-in 9.478 APE11-dist-out 5.963 APE10-dist-out 10.714 APE9-dist-in 3.851 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.07 0.187 0.223 A 370 317 5 0 0 0 [[37, 326]] 1.0 6ac9 CK1_VRK1_HUMAN CK1 8.9e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 6AC9B Q99986 21 341 396.0 ANP:401 ATPlike Inactive DFGin 7.916 14.739 BLAminus -115.54, 178.38 75.12, 91.43 -115.59, 17.29 297.69, 88.6 -57.57, -34.6 in-in in 8.093 Saltbr-in 2.77 HRD-in -83.61, -50.49 74.28, -0.88 in-in-out SNCiio in-out ActLoopNT-in 2.793 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -114.62, 8.0 APE9-dihe-na 78.71, -152.8 APE8-dihe-in -103.98, 122.42 APE8-rot-in 297.61 APE67-dihe-in -64.96, -28.03 -44.02, -51.48 APE12-dist-in 9.99 APE11-dist-out 5.433 APE10-dist-out 10.749 APE9-dist-in 3.727 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.07 0.187 0.223 B 370 316 5 0 0 0 [[37, 326]] 1.0 6ac9 CK1_VRK1_HUMAN CK1 8.9e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 6AC9C Q99986 24 341 396.0 ANP:402 ATPlike Inactive DFGin 7.927 14.325 BLAminus -121.92, 176.09 69.3, 88.62 -104.37, 22.99 293.32, 87.67 -64.92, -32.52 in-in in 7.605 Saltbr-in 2.793 HRD-in -88.58, -46.78 72.09, 4.58 in-in-out SNCiio in-out ActLoopNT-in 2.856 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -67.72, 154.65 APE9-dihe-na 94.16, -162.22 APE8-dihe-in -91.17, 117.25 APE8-rot-in 299.96 APE67-dihe-in -65.18, -24.09 -48.81, -46.56 APE12-dist-out 14.966 APE11-dist-in 13.64 APE10-dist-in 7.925 APE9-dist-in 4.153 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.07 0.187 0.223 C 370 307 11 0 0 0 [[37, 326]] 1.0 6ac9 CK1_VRK1_HUMAN CK1 8.9e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 6AC9D Q99986 23 341 396.0 ANP:402 ATPlike Inactive DFGin 7.739 14.33 BLAminus -116.24, 179.23 65.24, 86.32 -103.3, 26.16 293.03, 86.03 -64.75, -25.98 in-in in 7.722 Saltbr-in 2.797 HRD-in -87.33, -42.3 69.45, 1.55 in-in-out SNCiio in-out ActLoopNT-in 2.992 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -66.0, 154.0 APE9-dihe-na 92.71, -167.74 APE8-dihe-in -86.89, 111.15 APE8-rot-in 299.25 APE67-dihe-in -66.58, -28.49 -43.2, -46.61 APE12-dist-out 14.83 APE11-dist-in 13.447 APE10-dist-in 7.737 APE9-dist-in 4.26 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.07 0.187 0.223 D 370 306 13 0 0 0 [[37, 326]] 1.0 6ac9 CK1_VRK1_HUMAN CK1 8.9e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CMGC CDK1 CDK1_HUMAN 9SKQA P06493 3 288 297.0 ANP:60301 ATPlike Inactive DFGin 7.143 16.032 BLAminus -125.06, -177.1 57.55, 62.82 -86.84, 50.52 271.32, 82.93 -98.1, -26.9 in-out in 9.716 Saltbr-out 5.762 HRD-in -83.48, -58.42 64.77, 13.47 out-in-out SNCoio in-out ActLoopNT-in 2.685 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iiii APE10-dihe-na -142.74, 165.15 APE9-dihe-na 69.23, -36.98 APE8-dihe-out 60.52, 63.14 APE8-rot-out 73.99 APE67-dihe-out 57.27, -80.66 61.32, -166.6 APE12-dist-in 12.703 APE11-dist-in 10.027 APE10-dist-in 7.071 APE9-dist-in 3.731 None TPO161 TPO161 EM 3.4 999.0 999.0 A 302 286 0 0 0 0 [[4, 287]] 1.0 9skq CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
CMGC CDK12 CDK12_HUMAN 4CXAA Q9NYV4 718 1050 1490.0 ANP:2051 ATPlike Inactive DFGin 6.436 15.022 BLAminus -127.47, 178.63 59.83, 84.78 -103.34, 39.58 291.64, 72.71 -78.99, -14.54 in-in in 8.178 Saltbr-in 2.513 HRD-in -89.68, -50.66 63.81, 17.68 in-in-out SNCiio in-out ActLoopNT-in 2.793 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -113.43, 159.2 APE9-dihe-na 63.92, 139.76 APE8-dihe-in -56.37, 145.01 APE8-rot-out 63.76 APE67-dihe-in -64.68, -22.99 -55.23, -40.79 APE12-dist-in 13.212 APE11-dist-in 11.662 APE10-dist-in 7.363 APE9-dist-in 3.506 None TPO893 TPO893 XRAY 3.15 0.224 0.279 A 340 330 3 0 0 1 [[727, 1020]] 1.0 4cxa CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK2 CDK2_HUMAN 9QCVK P24941 1 292 298.0 ANP:60301 ATPlike Inactive DFGin 6.495 15.807 BLAminus -144.96, -178.89 57.85, 64.57 -85.72, 49.93 282.03, 73.0 -84.65, -33.03 in-out in 9.3 Saltbr-out 4.618 HRD-in -70.41, -54.19 69.05, 2.44 out-in-out SNCoio in-out ActLoopNT-in 2.576 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -164.79, 153.04 APE9-dihe-na -68.87, 164.19 APE8-dihe-in -61.62, 153.89 APE8-rot-out 41.16 APE67-dihe-in -67.77, -23.98 -60.52, -33.7 APE12-dist-in 11.155 APE11-dist-out 6.112 APE10-dist-out 8.897 APE9-dist-in 4.078 None None None EM 2.5 999.0 999.0 K 301 292 0 0 0 0 [[4, 286]] 1.0 9qcv CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK7 CDK7_HUMAN 8R99A P50613 10 311 346.0 ANP:401 ATPlike Inactive DFGin 6.921 15.074 BLAminus -136.18, 178.53 62.42, 80.05 -92.8, 32.41 285.07, 70.02 -64.17, -34.45 in-out in 9.457 Saltbr-out 5.606 HRD-in -70.53, -54.5 69.94, 6.7 out-in-out SNCoio in-out ActLoopNT-in 2.711 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -115.64, 148.75 APE9-dihe-na -60.57, 161.29 APE8-dihe-in -48.68, 142.11 APE8-rot-out 161.53 APE67-dihe-in -67.83, -20.09 -55.43, -38.94 APE12-dist-in 10.449 APE11-dist-out 5.162 APE10-dist-out 9.448 APE9-dist-in 3.715 W132R,S164D,T170E None None XRAY 1.81 0.178 0.22 A 371 283 19 0 0 0 [[12, 295]] 1.0 8r99 CMGC_CDK7_HUMAN CMGC 7.3e-78 269.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 9QCVJ P50613 10 346 346.0 ANP:60401 ATPlike Inactive DFGin 6.812 15.58 BLAminus -138.8, -173.47 57.69, 63.92 -85.78, 14.86 277.56, 80.3 -62.91, -29.56 in-out in 8.304 Saltbr-out 4.707 HRD-in -68.14, -50.51 67.46, 2.9 out-in-out SNCoio in-out ActLoopNT-in 2.816 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -128.9, 162.73 APE9-dihe-na -74.02, 167.46 APE8-dihe-in -56.29, 150.3 APE8-rot-out 36.33 APE67-dihe-in -61.72, -30.52 -65.73, -24.93 APE12-dist-in 11.244 APE11-dist-out 5.34 APE10-dist-out 8.996 APE9-dist-in 3.808 None None None EM 2.5 999.0 999.0 J 391 307 0 0 0 0 [[12, 295]] 1.0 9qcv CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 9SKQJ P50613 9 346 346.0 ANP:60401 ATPlike Inactive DFGin 7.089 16.079 BLAminus -134.4, -172.6 54.33, 63.76 -84.59, 21.04 273.82, 84.09 -68.06, -13.54 in-out in 8.685 Saltbr-out 3.604 HRD-in -66.63, -50.41 66.76, -1.97 out-in-out SNCoio in-out ActLoopNT-in 3.021 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -107.15, 155.19 APE9-dihe-na -64.85, 155.06 APE8-dihe-in -50.04, 149.57 APE8-rot-out 168.49 APE67-dihe-in -67.74, -34.69 -63.59, -17.75 APE12-dist-in 10.588 APE11-dist-out 5.67 APE10-dist-out 9.403 APE9-dist-in 3.987 None None None EM 3.4 999.0 999.0 J 391 306 0 0 0 0 [[12, 295]] 1.0 9skq CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BA P50613 1 311 346.0 ANP:401 ATPlike Inactive DFGin 6.667 15.04 None -136.41, -179.13 75.36, -66.57 59.32, 16.33 291.11, 69.78 55.95, 32.69 out-out out 13.486 Saltbr-out 13.754 HRD-in -65.3, -54.78 73.94, 0.68 out-out-out SNCooo out-out ActLoopNT-out 12.55 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -74.63, 115.42 APE9-dihe-na -115.54, -2.31 APE8-dihe-out -56.05, -31.84 APE8-rot-out 157.42 APE67-dihe-in -63.34, -23.16 -66.49, -24.29 APE12-dist-out 18.002 APE11-dist-out 20.187 APE10-dist-out 16.086 APE9-dist-out 11.465 S164D,T170E None None XRAY 2.21 0.195 0.243 A 352 301 10 0 0 0 [[12, 295]] 1.0 8r9b CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BB P50613 3 310 346.0 ANP:402 ATPlike Inactive DFGin 6.563 15.084 None -126.22, 177.01 84.52, -73.28 65.77, 22.93 292.14, 76.04 47.33, 39.02 out-out out 13.607 Saltbr-out 11.882 HRD-in -71.08, -53.54 74.78, -6.63 out-out-out SNCooo out-out ActLoopNT-out 12.936 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -81.04, 115.32 APE9-dihe-na -115.04, 1.93 APE8-dihe-out -60.49, -32.76 APE8-rot-out 168.86 APE67-dihe-in -59.67, -24.77 -68.61, -28.01 APE12-dist-out 17.779 APE11-dist-out 20.186 APE10-dist-out 16.157 APE9-dist-out 11.416 S164D,T170E None None XRAY 2.21 0.195 0.243 B 352 298 10 0 0 0 [[12, 295]] 1.0 8r9b CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BC P50613 8 311 346.0 ANP:402 ATPlike Inactive DFGin 6.451 15.34 None -116.21, 176.78 77.39, -97.04 64.16, 26.01 311.61, 20.83 46.47, 58.36 out-out out 13.104 Saltbr-out 12.133 HRD-in -78.41, -55.45 77.67, -2.52 out-out-out SNCooo out-out ActLoopNT-out 12.922 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 132.76 APE9-dihe-na -87.2, -35.35 APE8-dihe-out -49.87, -35.32 APE8-rot-in 271.7 APE67-dihe-in -63.34, -21.13 -58.67, -34.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.928 APE9-dist-out 10.934 S164D,T170E None None XRAY 2.21 0.195 0.243 C 352 276 28 0 0 12 [[12, 295]] 1.0 8r9b CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BD P50613 9 311 346.0 ANP:402 ATPlike Inactive DFGin 5.186 15.529 None -119.23, -173.72 58.44, -119.7 56.58, 114.74 106.06, 59.9 70.5, -151.21 out-out out 13.062 Saltbr-out 12.354 HRD-in -80.52, -56.05 80.67, -8.56 out-out-out SNCooo out-out ActLoopNT-out 13.055 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -29.49 APE9-dihe-na -113.47, -32.42 APE8-dihe-out -62.11, -27.52 APE8-rot-out 75.68 APE67-dihe-in -62.12, -24.79 -50.05, -35.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.16 APE9-dist-out 11.156 S164D,T170E None None XRAY 2.21 0.195 0.243 D 352 277 26 0 0 10 [[12, 295]] 1.0 8r9b CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK9 CDK9_HUMAN 3MIAA P50750 8 340 372.0 ANP:352 ATPlike Active DFGin 6.803 15.077 BLAminus -137.71, 176.33 64.58, 74.97 -96.55, 26.44 284.7, 90.38 -67.18, -14.54 in-in in 9.313 Saltbr-in 2.689 HRD-in -70.81, -51.43 63.16, 28.9 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.04, 160.49 APE9-dihe-na 82.03, 127.94 APE8-dihe-in -49.75, 143.51 APE8-rot-in 280.63 APE67-dihe-in -52.26, -14.47 -51.96, -57.94 APE12-dist-in 13.258 APE11-dist-in 11.524 APE10-dist-in 6.949 APE9-dist-in 3.523 None TPO186 TPO186 XRAY 3.0 0.219 0.287 A 351 325 8 0 0 0 [[19, 315]] 1.0 3mia CMGC_CDK9_HUMAN CMGC 5.1e-80 274.8 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CMGC CSNK2A1 CSK21_HUMAN 3JUHA P68400 2 335 391.0 ANP:339 ATPlike Active DFGin 7.401 16.242 BLAminus -115.69, -178.29 60.62, 71.57 -93.06, 11.37 295.1, 82.09 -62.22, -22.13 in-in in 9.721 Saltbr-in 2.746 HRD-in -70.06, -49.94 64.15, 21.46 in-in-in SNCiii in-in ActLoopNT-in 2.862 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.98, 153.86 APE9-dihe-na 70.33, -177.46 APE8-dihe-in -104.19, 142.14 APE8-rot-in 291.28 APE67-dihe-in -67.33, -12.83 -40.87, -55.27 APE12-dist-in 12.316 APE11-dist-in 9.578 APE10-dist-in 6.044 APE9-dist-in 3.086 V66A,M163L None None XRAY 1.66 0.158 0.218 A 335 334 0 0 0 0 [[39, 324]] 1.0 3juh CMGC_CSNK2A1_HUMAN CMGC 1.1e-70 244.1 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 3JUHB P68400 2 335 391.0 ANP:339 ATPlike Active DFGin 7.492 16.356 BLAminus -124.69, -176.29 51.46, 71.26 -80.35, 23.48 299.01, 83.37 -80.68, -22.43 in-in in 9.852 Saltbr-in 2.699 HRD-in -76.38, -50.5 78.84, -1.13 in-in-in SNCiii in-in ActLoopNT-in 2.807 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.59, 175.23 APE9-dihe-na 56.07, 138.8 APE8-dihe-in -58.03, 149.04 APE8-rot-in 282.66 APE67-dihe-in -69.98, -19.52 -43.94, -46.02 APE12-dist-in 12.714 APE11-dist-in 9.541 APE10-dist-in 5.884 APE9-dist-in 3.411 V66A,M163L None None XRAY 1.66 0.158 0.218 B 335 334 0 0 0 0 [[39, 324]] 1.0 3juh CMGC_CSNK2A1_HUMAN CMGC 1.1e-70 244.1 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 3NSZA P68400 2 328 391.0 ANP:1000 ATPlike Active DFGin 7.29 16.639 BLAminus -116.89, -174.28 57.53, 72.95 -91.24, 19.04 295.43, 81.74 -67.97, -19.44 in-in in 9.56 Saltbr-in 2.721 HRD-in -71.38, -46.87 68.1, 12.99 in-in-in SNCiii in-in ActLoopNT-in 2.869 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.59, 174.99 APE9-dihe-na 61.7, -173.37 APE8-dihe-in -118.84, 140.8 APE8-rot-in 296.4 APE67-dihe-in -69.07, -13.11 -30.5, -60.15 APE12-dist-in 12.605 APE11-dist-in 10.316 APE10-dist-in 6.145 APE9-dist-in 2.961 None None None XRAY 1.3 0.169 0.187 A 330 327 0 0 0 0 [[39, 324]] 1.0 3nsz CMGC_CSNK2A1_HUMAN CMGC 1.3e-69 240.7 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 1PJKA P68400 2 332 391.0 ANP:340 ATPlike Active DFGin 7.44 16.238 BLAminus -115.92, -179.78 53.21, 80.99 -96.44, 28.53 295.64, 78.1 -72.28, -30.66 in-in in 8.93 Saltbr-in 2.81 HRD-in -80.54, -40.11 57.34, 9.1 in-in-in SNCiii in-in ActLoopNT-in 3.019 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.58, 173.24 APE9-dihe-na 63.2, 174.94 APE8-dihe-in -93.15, 157.9 APE8-rot-in 277.8 APE67-dihe-in -66.77, -23.27 -54.74, -47.48 APE12-dist-in 13.026 APE11-dist-in 10.669 APE10-dist-in 6.368 APE9-dist-in 3.173 None None None XRAY 2.5 0.188 0.257 A 334 331 0 0 0 0 [[39, 324]] 1.0 1pjk CMGC_CSNK2A1_HUMAN CMGC 1.3e-69 240.6 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 2PVRA P68400 2 329 391.0 ANP:6004 ATPlike Active DFGin 7.492 16.497 BLAminus -121.67, -179.6 56.35, 70.32 -89.0, 17.49 296.64, 81.69 -72.81, -15.87 in-in in 9.284 Saltbr-in 2.7 HRD-in -75.03, -46.77 70.22, 6.37 in-in-in SNCiii in-in ActLoopNT-in 2.86 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.8, 175.01 APE9-dihe-na 60.61, 163.14 APE8-dihe-in -93.89, 147.69 APE8-rot-in 305.18 APE67-dihe-in -67.68, -15.16 -34.32, -58.13 APE12-dist-in 12.728 APE11-dist-in 10.346 APE10-dist-in 6.131 APE9-dist-in 3.189 None None None XRAY 1.605 0.187 0.241 A 334 328 0 0 0 0 [[39, 324]] 1.0 2pvr CMGC_CSNK2A1_HUMAN CMGC 1.3e-69 240.6 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 3WOWA P68400 2 335 391.0 ANP:403 ATPlike Inactive DFGin 7.362 16.211 BLAminus -119.7, -164.32 31.16, 87.67 -91.29, 15.78 292.48, 84.38 -76.59, -15.17 in-in in 9.013 Saltbr-in 2.897 HRD-in -75.03, -42.77 66.59, 8.6 in-in-out SNCiio in-out ActLoopNT-in 2.827 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -147.66, 173.4 APE9-dihe-na 59.33, 149.57 APE8-dihe-in -60.19, 149.81 APE8-rot-out 155.74 APE67-dihe-in -68.18, -10.89 -45.04, -52.54 APE12-dist-in 12.463 APE11-dist-in 9.893 APE10-dist-in 6.004 APE9-dist-in 3.238 None None None XRAY 2.5 0.187 0.24 A 340 334 0 0 0 0 [[39, 324]] 1.0 3wow CMGC_CSNK2A1_HUMAN CMGC 1.4e-69 240.5 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 1JWHA P68400 2 337 391.0 ANP:340 ATPlike Inactive DFGin 7.252 16.235 BLAminus -136.81, -165.56 40.66, 74.27 -89.27, 13.16 294.34, 91.77 -66.65, -32.67 in-in in 9.564 Saltbr-in 2.506 HRD-in -80.54, -35.51 50.69, 18.56 in-in-out SNCiio in-out ActLoopNT-in 2.932 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -124.17, 169.91 APE9-dihe-na 68.04, 157.3 APE8-dihe-in -72.41, 153.53 APE8-rot-out 204.94 APE67-dihe-in -51.97, -16.72 -49.32, -64.87 APE12-dist-in 12.731 APE11-dist-in 10.856 APE10-dist-in 6.286 APE9-dist-in 3.369 None None None XRAY 3.1 0.267 0.338 A 337 336 0 0 0 0 [[39, 324]] 1.0 1jwh CMGC_CSNK2A1_HUMAN CMGC 1.4e-69 240.6 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 3U87A P68400 2 331 391.0 ANP:60401 ATPlike Inactive DFGin 7.545 16.231 BLAminus -123.37, -169.57 51.0, 85.39 -106.65, 25.22 299.48, 83.64 -72.72, -19.34 in-in in 9.267 Saltbr-in 2.765 HRD-in -71.91, -49.46 70.99, 8.66 in-in-out SNCiio in-out ActLoopNT-in 2.851 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.96, 169.28 APE9-dihe-na 66.95, 166.44 APE8-dihe-in -75.94, 153.25 APE8-rot-out 174.74 APE67-dihe-in -70.96, -11.07 -53.15, -46.69 APE12-dist-in 12.843 APE11-dist-in 11.035 APE10-dist-in 6.142 APE9-dist-in 3.539 None None None XRAY 2.9 0.187 0.218 A 349 324 0 0 0 0 [[39, 324]] 1.0 3u87 CMGC_CSNK2A1_HUMAN CMGC 1.5e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 3U87B P68400 2 331 391.0 ANP:60401 ATPlike Active DFGin 7.471 16.335 BLAminus -123.33, -169.35 50.94, 85.5 -106.65, 24.88 299.58, 83.47 -72.97, -19.72 in-in in 9.505 Saltbr-in 2.848 HRD-in -72.0, -49.6 70.96, 8.41 in-in-in SNCiii in-in ActLoopNT-in 2.78 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.34, 168.89 APE9-dihe-na 66.61, 166.24 APE8-dihe-in -76.34, 153.62 APE8-rot-in 296.27 APE67-dihe-in -70.99, -10.83 -52.99, -46.79 APE12-dist-in 12.822 APE11-dist-in 10.801 APE10-dist-in 6.15 APE9-dist-in 3.577 None None None XRAY 2.9 0.187 0.218 B 349 324 0 0 0 0 [[39, 324]] 1.0 3u87 CMGC_CSNK2A1_HUMAN CMGC 1.5e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A2 CSK22_HUMAN 8QCGA P19784 7 330 350.0 ANP:401 ATPlike Inactive DFGin 7.292 16.406 BLAminus -116.12, -179.5 60.93, 75.12 -92.44, 17.38 295.14, 82.0 -69.37, -19.53 in-out in 9.997 Saltbr-out 4.596 HRD-in -74.12, -49.68 72.07, 8.96 out-in-in SNCoii in-in ActLoopNT-in 2.89 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.46, 172.69 APE9-dihe-na 61.42, 170.02 APE8-dihe-in -97.67, 147.66 APE8-rot-in 300.74 APE67-dihe-in -69.16, -14.55 -36.76, -56.59 APE12-dist-in 12.627 APE11-dist-in 10.181 APE10-dist-in 6.131 APE9-dist-in 3.12 C336S None None XRAY 1.04 0.151 0.17 A 364 324 0 0 0 0 [[40, 325]] 1.0 8qcg CMGC_CSNK2A2_HUMAN CMGC 1e-69 241.0 1 301 301 175 176 177 179 181 69 82 86 154 156 155 157 215 202 197 196 195 194 193 192 191 115 Casein kinase II subunit alpha'
CMGC CSNK2A2 CSK22_HUMAN 8QCGB P19784 7 333 350.0 ANP:401 ATPlike Active DFGin 7.314 16.209 BLAminus -113.91, -178.96 61.11, 75.42 -92.86, 17.98 298.38, 79.8 -69.62, -20.0 in-in in 9.436 Saltbr-in 2.83 HRD-in -72.51, -49.6 69.57, 9.93 in-in-in SNCiii in-in ActLoopNT-in 2.828 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.91, 170.94 APE9-dihe-na 61.2, 166.37 APE8-dihe-in -93.43, 149.98 APE8-rot-in 300.62 APE67-dihe-in -69.2, -15.18 -40.28, -54.89 APE12-dist-in 12.657 APE11-dist-in 10.295 APE10-dist-in 6.172 APE9-dist-in 3.11 C336S None None XRAY 1.04 0.151 0.17 B 364 327 0 0 0 0 [[40, 325]] 1.0 8qcg CMGC_CSNK2A2_HUMAN CMGC 1e-69 241.0 1 301 301 175 176 177 179 181 69 82 86 154 156 155 157 215 202 197 196 195 194 193 192 191 115 Casein kinase II subunit alpha'
CMGC DYRK1A DYR1A_HUMAN 7A4OA Q13627 136 481 763.0 ANP:501 ATPlike Active DFGin 7.404 15.034 BLAminus -121.6, 173.77 67.88, 73.96 -92.34, 22.26 284.87, 82.1 -70.26, -21.97 in-in in 8.684 Saltbr-in 2.793 HRD-in -65.03, -49.19 79.83, -0.94 in-in-in SNCiii in-in ActLoopNT-in 2.8 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.61, 174.39 APE9-dihe-na 70.74, 151.67 APE8-dihe-in -72.34, 134.57 APE8-rot-in 295.77 APE67-dihe-in -65.19, -24.46 -43.45, -47.13 APE12-dist-in 10.098 APE11-dist-in 12.237 APE10-dist-in 7.723 APE9-dist-in 3.156 None PTR321 PTR321 XRAY 1.9 0.18 0.203 A 382 341 5 0 0 0 [[159, 479]] 1.0 7a4o CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7A4OB Q13627 134 481 763.0 ANP:501 ATPlike Inactive DFGin 7.223 15.047 BLAminus -127.4, 170.29 72.8, 80.08 -93.18, 24.5 286.73, 76.67 -71.46, -26.03 in-in in 8.365 Saltbr-in 2.797 HRD-in -57.9, -49.71 71.19, 2.83 in-in-out SNCiio in-out ActLoopNT-in 2.84 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -84.65, 164.16 APE9-dihe-na 75.07, 150.77 APE8-dihe-in -68.35, 138.34 APE8-rot-in 298.16 APE67-dihe-in -63.89, -24.74 -46.52, -48.39 APE12-dist-out 14.097 APE11-dist-in 11.896 APE10-dist-in 7.537 APE9-dist-in 3.028 None PTR321 PTR321 XRAY 1.9 0.18 0.203 B 382 341 7 0 0 0 [[159, 479]] 1.0 7a4o CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC GSK3B GSK3B_HUMAN 1J1BA P49841 35 388 420.0 ANP:60430 ATPlike Active DFGin 6.767 13.788 BLAminus -136.8, -178.88 61.6, 83.12 -97.64, 25.1 286.09, 80.4 -68.7, -13.11 in-in in 8.566 Saltbr-in 2.59 HRD-in -71.16, -45.98 70.36, 3.88 in-in-in SNCiii in-in ActLoopNT-in 3.009 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -88.52, 175.26 APE9-dihe-na 75.44, 133.64 APE8-dihe-in -75.76, 147.49 APE8-rot-in 306.57 APE67-dihe-inflip 98.15, -33.72 -56.43, 141.52 APE12-dist-in 13.056 APE11-dist-in 10.974 APE10-dist-in 5.893 APE9-dist-in 3.112 None None None XRAY 1.8 0.216 0.242 A 420 354 0 0 0 0 [[56, 340]] 1.0 1j1b CMGC_GSK3B_HUMAN CMGC 3.2e-70 242.8 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 1J1BB P49841 23 386 420.0 ANP:60930 ATPlike Active DFGin 6.609 13.669 BLAminus -136.4, -177.03 61.49, 81.88 -98.08, 27.2 288.49, 82.07 -71.33, -13.14 in-in in 8.457 Saltbr-in 2.713 HRD-in -67.51, -45.87 68.87, 6.43 in-in-in SNCiii in-in ActLoopNT-in 2.962 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -90.88, 174.17 APE9-dihe-na 76.18, 138.08 APE8-dihe-in -76.12, 141.41 APE8-rot-in 301.11 APE67-dihe-inflip 98.0, -37.59 -54.78, 144.25 APE12-dist-in 12.978 APE11-dist-in 11.066 APE10-dist-in 6.011 APE9-dist-in 3.174 None None None XRAY 1.8 0.216 0.242 B 420 364 0 0 0 0 [[56, 340]] 1.0 1j1b CMGC_GSK3B_HUMAN CMGC 3.2e-70 242.8 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 8XN6A P49841 35 384 420.0 ANP:501 ATPlike Active DFGin 6.682 13.862 BLAminus -137.72, 173.39 67.73, 84.48 -99.84, 22.57 287.77, 80.54 -65.33, -24.58 in-in in 8.463 Saltbr-in 2.63 HRD-in -71.05, -47.88 67.82, 15.5 in-in-in SNCiii in-in ActLoopNT-in 3.054 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.0, 164.43 APE9-dihe-na 85.44, 135.36 APE8-dihe-in -74.2, 151.55 APE8-rot-in 291.81 APE67-dihe-in -69.28, -17.83 -36.59, -67.98 APE12-dist-in 12.907 APE11-dist-in 10.787 APE10-dist-in 5.68 APE9-dist-in 3.182 None None None XRAY 2.4 0.194 0.242 A 421 350 0 0 0 0 [[56, 340]] 1.0 8xn6 CMGC_GSK3B_HUMAN CMGC 3.3e-70 242.8 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 8XN6B P49841 26 386 420.0 ANP:501 ATPlike Inactive DFGin 6.538 13.65 BLAminus -128.79, 173.26 73.68, 79.74 -95.9, 22.51 291.63, 80.46 -68.54, -21.83 in-in in 8.329 Saltbr-in 2.823 HRD-in -66.59, -53.03 79.09, 5.6 in-in-out SNCiio in-out ActLoopNT-in 2.951 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -88.32, 165.9 APE9-dihe-na 83.63, 132.42 APE8-dihe-in -59.67, 147.17 APE8-rot-out 189.94 APE67-dihe-in -64.51, -21.68 -60.38, -49.59 APE12-dist-in 13.024 APE11-dist-in 10.97 APE10-dist-in 5.846 APE9-dist-in 3.081 None None None XRAY 2.4 0.194 0.242 B 421 359 2 0 0 0 [[56, 340]] 1.0 8xn6 CMGC_GSK3B_HUMAN CMGC 3.3e-70 242.8 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 1PYXA P49841 35 386 420.0 ANP:1001 ATPlike Active DFGin 6.584 13.622 BLAminus -138.81, -178.07 65.18, 79.92 -98.83, 26.07 289.95, 78.27 -73.24, -7.6 in-in in 8.373 Saltbr-in 2.765 HRD-in -67.79, -47.84 71.28, 6.53 in-in-in SNCiii in-in ActLoopNT-in 2.948 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -86.12, 170.17 APE9-dihe-na 80.64, 129.74 APE8-dihe-in -63.79, 140.05 APE8-rot-in 299.48 APE67-dihe-in -56.43, -21.61 -20.65, -80.28 APE12-dist-in 12.903 APE11-dist-in 10.937 APE10-dist-in 5.784 APE9-dist-in 3.15 None None None XRAY 2.4 0.206 0.233 A 422 343 9 0 0 0 [[56, 340]] 1.0 1pyx CMGC_GSK3B_HUMAN CMGC 3.3e-70 242.8 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 1PYXB P49841 35 383 420.0 ANP:2001 ATPlike Active DFGin 6.593 13.718 BLAminus -140.94, -178.47 65.26, 79.98 -98.11, 22.32 290.75, 76.51 -68.32, -7.73 in-in in 8.488 Saltbr-in 2.666 HRD-in -69.98, -47.18 70.83, 5.6 in-in-in SNCiii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -89.3, 169.41 APE9-dihe-na 81.27, 131.24 APE8-dihe-in -66.67, 140.79 APE8-rot-in 300.74 APE67-dihe-in -56.9, -22.2 -20.58, -79.9 APE12-dist-in 12.838 APE11-dist-in 10.861 APE10-dist-in 5.718 APE9-dist-in 3.132 None None None XRAY 2.4 0.206 0.233 B 422 338 11 0 0 0 [[56, 340]] 1.0 1pyx CMGC_GSK3B_HUMAN CMGC 3.3e-70 242.8 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC MAPK1 MK01_HUMAN 4H3QA P28482 9 360 360.0 ANP:401 ATPlike Inactive DFGin 6.603 15.682 BLAminus -131.43, 178.9 70.32, 68.42 -96.0, 22.91 290.2, 68.59 -63.35, -20.75 in-in in 9.233 Saltbr-in 2.821 HRD-in -71.26, -48.66 68.7, 4.98 in-in-out SNCiio in-out ActLoopNT-in 2.942 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioo APE10-dihe-na -133.14, 155.68 APE9-dihe-na -60.56, -35.88 APE8-dihe-out -124.57, -73.58 APE8-rot-out 150.68 APE67-dihe-out -67.06, -6.51 92.51, -9.23 APE12-dist-in 9.135 APE11-dist-in 11.662 APE10-dist-out 8.752 APE9-dist-out 10.9 R77A,C161S,I255G,E314A None None XRAY 2.2 0.184 0.232 A 362 352 0 0 0 0 [[25, 313]] 1.0 4h3q CMGC_MAPK1_HUMAN CMGC 3.4e-85 291.8 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6OPGA P28482 10 358 360.0 ANP:60401 ATPlike Active DFGin 6.535 14.668 BLAminus -130.49, -173.97 55.35, 72.85 -87.66, 25.26 285.94, 65.79 -65.31, -19.22 in-in in 9.066 Saltbr-in 2.695 HRD-in -72.87, -54.34 77.9, 3.87 in-in-in SNCiii in-in ActLoopNT-in 2.758 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -102.35, 163.88 APE9-dihe-na 79.13, 168.47 APE8-dihe-in -88.92, 138.85 APE8-rot-in 292.11 APE67-dihe-in -68.23, -14.82 -51.35, -45.86 APE12-dist-in 12.57 APE11-dist-in 11.134 APE10-dist-in 6.653 APE9-dist-in 2.942 None TPO185,PTR187 TPO185,PTR187 XRAY 2.9 0.16 0.239 A 354 349 0 0 0 0 [[25, 313]] 1.0 6opg CMGC_MAPK1_HUMAN CMGC 8.6e-86 293.8 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 2Y9QA P28482 9 358 360.0 ANP:1359 ATPlike Inactive DFGin 6.776 15.446 BLAminus -131.56, -173.58 71.27, 62.6 -94.15, 18.41 284.56, 67.7 -60.61, -22.82 in-in in 9.107 Saltbr-in 2.791 HRD-in -69.38, -48.16 75.91, -5.63 in-in-out SNCiio in-out ActLoopNT-in 2.788 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -136.29, 162.19 APE9-dihe-na -69.67, -30.11 APE8-dihe-in -153.45, 140.36 APE8-rot-out 183.83 APE67-dihe-in -69.16, -12.41 -110.3, 4.7 APE12-dist-in 9.663 APE11-dist-in 12.83 APE10-dist-out 9.194 APE9-dist-out 11.509 None None None XRAY 1.55 0.156 0.177 A 362 350 0 0 0 0 [[25, 313]] 1.0 2y9q CMGC_MAPK1_HUMAN CMGC 9.3e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4FMQA P28482 9 358 360.0 ANP:401 ATPlike Inactive DFGin 6.797 15.309 BLAminus -133.64, -170.94 67.61, 66.1 -98.24, 21.64 282.65, 68.61 -61.3, -22.42 in-in in 9.131 Saltbr-in 2.936 HRD-in -73.07, -47.52 74.25, -10.43 in-in-out SNCiio in-out ActLoopNT-in 2.83 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -138.4, 159.9 APE9-dihe-na -70.94, -24.68 APE8-dihe-in -158.11, 141.22 APE8-rot-out 179.47 APE67-dihe-in -66.85, -11.48 -113.88, 6.26 APE12-dist-in 9.474 APE11-dist-in 12.7 APE10-dist-out 9.225 APE9-dist-out 11.64 None None None XRAY 2.098 0.182 0.224 A 362 350 0 0 0 0 [[25, 313]] 1.0 4fmq CMGC_MAPK1_HUMAN CMGC 9.3e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4NIFB P28482 9 360 360.0 ANP:401 ATPlike Inactive DFGin 6.764 15.409 BLAminus -131.87, -169.42 69.51, 63.01 -98.39, 22.71 281.57, 68.87 -63.28, -26.61 in-in in 9.008 Saltbr-in 2.783 HRD-in -68.77, -49.09 76.18, -3.84 in-in-out SNCiio in-out ActLoopNT-in 2.728 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -127.8, 161.08 APE9-dihe-na -75.51, -26.3 APE8-dihe-in -152.23, 138.84 APE8-rot-out 180.18 APE67-dihe-in -71.26, -8.82 -111.88, 5.33 APE12-dist-in 8.2 APE11-dist-in 11.961 APE10-dist-out 8.903 APE9-dist-out 11.513 None None None XRAY 2.15 0.161 0.208 B 362 349 3 0 0 3 [[25, 313]] 1.0 4nif CMGC_MAPK1_HUMAN CMGC 9.3e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4NIFE P28482 10 360 360.0 ANP:401 ATPlike Inactive DFGin 6.799 15.601 BLAminus -132.52, -168.43 65.68, 64.41 -97.79, 21.09 277.61, 67.0 -63.55, -23.2 in-in in 9.17 Saltbr-in 2.713 HRD-in -70.38, -48.01 73.58, -2.52 in-in-out SNCiio in-out ActLoopNT-in 2.729 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -128.04, 157.14 APE9-dihe-na -71.47, -27.38 APE8-dihe-in -153.58, 137.78 APE8-rot-out 179.37 APE67-dihe-in -68.22, -5.95 -110.7, 4.02 APE12-dist-in 8.144 APE11-dist-in 11.929 APE10-dist-out 8.941 APE9-dist-out 11.528 None None None XRAY 2.15 0.161 0.208 E 362 348 3 0 0 3 [[25, 313]] 1.0 4nif CMGC_MAPK1_HUMAN CMGC 9.3e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8PSRA P28482 1 358 360.0 ANP:401 ATPlike Inactive DFGin 6.763 15.116 BLAminus -130.96, -167.28 68.25, 62.57 -95.64, 20.11 282.69, 71.74 -68.98, -15.25 in-in in 8.941 Saltbr-in 2.823 HRD-in -68.74, -46.55 75.16, -5.99 in-in-out SNCiio in-out ActLoopNT-in 2.769 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -133.02, 153.53 APE9-dihe-na -66.89, -30.36 APE8-dihe-in -146.2, 134.03 APE8-rot-out 178.25 APE67-dihe-in -71.02, -10.13 -100.56, 5.83 APE12-dist-in 8.168 APE11-dist-in 11.547 APE10-dist-out 8.889 APE9-dist-out 11.361 None None None XRAY 1.85 0.183 0.209 A 364 354 4 0 0 4 [[25, 313]] 1.0 8psr CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 3TEIA P28482 10 358 360.0 ANP:401 ATPlike Inactive DFGin 6.743 15.947 BLAminus -130.8, -176.53 59.31, 74.36 -93.64, 10.5 288.08, 72.41 -50.44, -31.09 in-in in 9.271 Saltbr-in 3.199 HRD-in -69.93, -52.25 74.6, -17.82 in-in-out SNCiio in-out ActLoopNT-in 2.753 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na 66.02, 77.59 APE9-dihe-na -53.11, -45.5 APE8-dihe-in -109.04, 134.77 APE8-rot-out 40.2 APE67-dihe-in -60.63, -33.66 -94.81, 4.48 APE12-dist-in 8.784 APE11-dist-in 10.993 APE10-dist-out 8.507 APE9-dist-out 11.182 R77A,E314A None None XRAY 2.404 0.199 0.235 A 362 339 10 0 0 7 [[25, 313]] 1.0 3tei CMGC_MAPK1_HUMAN CMGC 1.6e-85 292.9 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4H3PA P28482 11 359 360.0 ANP:401 ATPlike Inactive DFGin 6.749 16.129 BLAminus -129.02, -179.26 65.06, 71.95 -98.46, 28.28 294.01, 75.31 -57.14, -23.59 in-in in 9.601 Saltbr-in 3.052 HRD-in -79.45, -54.12 78.74, 4.99 in-in-out SNCiio in-out ActLoopNT-in 2.727 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -109.42, 169.7 APE9-dihe-na -56.98, -72.96 APE8-dihe-in -103.33, 144.18 APE8-rot-out 6.69 APE67-dihe-in -56.41, -28.74 -91.67, -5.29 APE12-dist-in 8.895 APE11-dist-in 9.185 APE10-dist-out 8.383 APE9-dist-out 9.732 R77A,E314A None None XRAY 2.3 0.18 0.224 A 362 342 7 0 0 7 [[25, 313]] 1.0 4h3p CMGC_MAPK1_HUMAN CMGC 1.6e-85 292.9 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4H3PD P28482 11 359 360.0 ANP:401 ATPlike Inactive DFGin 6.742 16.27 BLAminus -128.42, -178.25 63.92, 70.53 -94.38, 28.0 287.67, 73.89 -60.9, -21.54 in-in in 9.383 Saltbr-in 3.454 HRD-in -75.51, -54.76 82.18, -2.55 in-in-out SNCiio in-out ActLoopNT-in 2.657 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 42.36 APE8-rot-out 66.34 APE67-dihe-in -61.9, -28.03 -63.57, -9.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 R77A,E314A None None XRAY 2.3 0.18 0.224 D 362 338 11 0 0 11 [[25, 313]] 1.0 4h3p CMGC_MAPK1_HUMAN CMGC 1.6e-85 292.9 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8PT0A P28482 11 358 360.0 ANP:401,EAI:403 ATPlike,Allosteric Inactive DFGin 6.703 15.518 BLAminus -130.99, -173.26 73.92, 62.07 -95.1, 17.63 279.55, 70.77 -68.45, -13.49 in-in in 9.141 Saltbr-in 2.87 HRD-in -71.96, -48.9 77.41, -4.12 in-in-out SNCiio in-out ActLoopNT-in 2.692 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -110.07, -36.78 APE9-dihe-na -83.86, 177.79 APE8-dihe-in -68.52, 145.31 APE8-rot-out 191.04 APE67-dihe-in -66.51, -15.78 -105.25, 7.42 APE12-dist-out 6.875 APE11-dist-in 12.443 APE10-dist-out 12.554 APE9-dist-out 9.994 None None None XRAY 1.65 0.178 0.207 A 364 348 0 0 0 0 [[25, 313]] 1.0 8pt0 CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8PT1A P28482 11 359 360.0 ANP:401,E2A:402 ATPlike,Allosteric Inactive DFGin 6.753 15.486 BLAminus -130.01, -175.04 73.39, 64.08 -95.46, 18.76 282.28, 68.91 -63.67, -19.55 in-in in 9.189 Saltbr-in 2.849 HRD-in -70.21, -47.68 76.07, -5.14 in-in-out SNCiio in-out ActLoopNT-in 2.672 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -121.06, -17.86 APE9-dihe-na -106.9, -177.78 APE8-dihe-in -78.1, 145.34 APE8-rot-out 186.54 APE67-dihe-in -67.62, -15.27 -108.68, 6.96 APE12-dist-in 7.171 APE11-dist-in 12.615 APE10-dist-out 12.631 APE9-dist-out 10.275 None None None XRAY 1.8 0.18 0.206 A 364 349 0 0 0 0 [[25, 313]] 1.0 8pt1 CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8PT5A P28482 10 358 360.0 ANP:401,D5R:402 ATPlike,Allosteric Inactive DFGin 6.79 15.304 BLAminus -138.03, -165.34 60.19, 62.86 -94.09, 21.06 289.01, 63.44 -59.86, -23.15 in-in in 9.091 Saltbr-in 2.882 HRD-in -75.18, -47.36 71.89, 2.28 in-in-out SNCiio in-out ActLoopNT-in 2.686 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -138.15, 158.79 APE9-dihe-na -71.62, -19.38 APE8-dihe-in -154.23, 140.23 APE8-rot-out 183.5 APE67-dihe-in -63.22, -13.66 -125.12, 20.04 APE12-dist-in 7.631 APE11-dist-in 11.469 APE10-dist-out 8.739 APE9-dist-out 11.287 None None None XRAY 1.95 0.206 0.235 A 364 336 10 0 0 10 [[25, 313]] 1.0 8pt5 CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8R5FA P28482 11 359 360.0 ANP:401,Y3H:403 ATPlike,Allosteric Inactive DFGin 6.715 15.459 BLAminus -133.12, -173.02 67.59, 67.52 -98.89, 23.72 283.56, 67.1 -69.6, -17.36 in-in in 9.141 Saltbr-in 2.907 HRD-in -75.1, -48.03 76.68, -4.69 in-in-out SNCiio in-out ActLoopNT-in 2.693 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -92.27 APE8-dihe-in -89.34, 137.7 APE8-rot-out 190.9 APE67-dihe-in -68.19, -17.69 -92.76, -0.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.617 None None None XRAY 1.65 0.194 0.218 A 364 337 12 0 0 12 [[25, 313]] 1.0 8r5f CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8PT3A P28482 10 359 360.0 D7O:401,ANP:405 Allosteric,ATPlike Inactive DFGin 6.746 16.295 BLAminus -133.05, 179.18 60.24, 82.09 -94.36, 25.54 283.73, 70.47 -58.59, -24.6 in-out in 9.278 Saltbr-out 4.094 HRD-in -70.52, -51.82 77.79, -2.53 out-in-out SNCoio in-out ActLoopNT-in 2.751 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oiio APE10-dihe-na -134.69, 123.91 APE9-dihe-na -78.34, -33.65 APE8-dihe-in -152.41, 145.11 APE8-rot-out 185.39 APE67-dihe-in -63.56, -20.16 -105.73, 9.6 APE12-dist-out 6.368 APE11-dist-in 8.592 APE10-dist-in 7.973 APE9-dist-out 9.858 None None None XRAY 1.8 0.189 0.222 A 364 344 6 0 0 6 [[25, 313]] 1.0 8pt3 CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK10 MK10_HUMAN 8WGFA P53779 44 400 464.0 ANP:60401 ATPlike Inactive DFGin 3.669 14.04 ABAminus -79.02, -31.55 -136.84, 175.04 -119.07, 8.28 296.56, 96.93 82.35, -157.09 in-out in 9.384 Saltbr-out 5.018 HRD-in -58.91, -63.96 74.85, 1.04 out-out-out SNCooo out-out ActLoopNT-out 7.325 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -90.96, 137.03 APE9-dihe-na -73.55, 128.96 APE8-dihe-in -72.45, 116.03 APE8-rot-in 306.62 APE67-dihe-in -62.34, -20.8 -105.53, -9.26 APE12-dist-out 20.953 APE11-dist-out 15.692 APE10-dist-out 16.374 APE9-dist-out 11.022 None None None XRAY 1.85 0.212 0.266 A 364 345 4 0 0 4 [[64, 359]] 1.0 8wgf CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 1JNKA P53779 45 400 464.0 ANP:1001 ATPlike Inactive DFGin 3.929 14.397 ABAminus -78.22, -57.34 -98.44, 177.55 -110.1, 6.65 294.57, 85.06 91.46, -137.75 in-out in 9.683 Saltbr-out 4.075 HRD-in -45.57, -68.64 69.61, 1.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -66.55, 160.68 APE9-dihe-na -118.58, 134.57 APE8-dihe-in -89.41, 118.53 APE8-rot-in 305.71 APE67-dihe-in -40.1, -24.2 -103.88, -20.46 APE12-dist-out 21.317 APE11-dist-out 17.873 APE10-dist-out 16.746 APE9-dist-out 11.497 None None None XRAY 2.3 0.222 0.274 A 423 346 5 0 0 5 [[64, 359]] 1.0 1jnk CMGC_MAPK10_HUMAN CMGC 2.3e-85 292.5 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 4Z9LA P53779 45 400 464.0 ANP:501,880:502 Allosteric,Type1 Inactive DFGin 4.174 14.445 ABAminus -84.27, -25.72 -124.69, 176.34 -117.02, 11.08 300.14, 92.59 64.94, -148.04 out-out out 10.091 Saltbr-out 4.206 HRD-in -57.93, -67.24 75.49, -7.3 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 141.12 APE8-dihe-in -74.24, 114.86 APE8-rot-in 306.24 APE67-dihe-in -45.55, -30.35 -108.57, -9.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.617 None None None XRAY 2.1 0.201 0.226 A 364 333 12 0 0 10 [[64, 359]] 1.0 4z9l CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK12 MK12_HUMAN 1CM8A P53778 8 353 367.0 ANP:60400 ATPlike Active DFGin 6.965 14.774 BLAminus -109.08, -177.81 49.88, 82.62 -94.66, 21.96 279.65, 74.31 -61.38, -21.21 in-in in 9.0 Saltbr-in 2.777 HRD-in -80.35, -48.18 64.34, 20.91 in-in-in SNCiii in-in ActLoopNT-in 2.793 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.88, 159.85 APE9-dihe-na 73.62, 141.22 APE8-dihe-in -70.32, 134.6 APE8-rot-in 295.09 APE67-dihe-in -62.17, -12.08 -34.13, -61.33 APE12-dist-in 11.604 APE11-dist-in 10.956 APE10-dist-in 6.991 APE9-dist-in 3.072 None TPO183,PTR185 TPO183,PTR185 XRAY 2.4 0.232 0.283 A 367 329 6 0 0 0 [[27, 311]] 1.0 1cm8 CMGC_MAPK12_HUMAN CMGC 5.6e-85 291.2 1 301 301 170 171 172 174 176 56 74 78 150 152 151 153 208 195 190 189 188 187 186 185 184 110 Mitogen-activated protein kinase 12
CMGC MAPK12 MK12_HUMAN 1CM8B P53778 8 353 367.0 ANP:61400 ATPlike Active DFGin 6.965 14.794 BLAminus -106.93, -177.79 50.51, 81.99 -94.3, 22.09 279.91, 74.94 -61.07, -21.75 in-in in 9.031 Saltbr-in 2.759 HRD-in -80.7, -47.04 63.03, 19.82 in-in-in SNCiii in-in ActLoopNT-in 2.817 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.88, 160.62 APE9-dihe-na 73.12, 141.25 APE8-dihe-in -70.38, 133.34 APE8-rot-in 295.67 APE67-dihe-in -62.05, -11.85 -33.55, -61.0 APE12-dist-in 11.613 APE11-dist-in 10.95 APE10-dist-in 6.996 APE9-dist-in 3.048 None TPO183,PTR185 TPO183,PTR185 XRAY 2.4 0.232 0.283 B 367 329 6 0 0 0 [[27, 311]] 1.0 1cm8 CMGC_MAPK12_HUMAN CMGC 5.6e-85 291.2 1 301 301 170 171 172 174 176 56 74 78 150 152 151 153 208 195 190 189 188 187 186 185 184 110 Mitogen-activated protein kinase 12
CMGC MAPK7 MK07_HUMAN 4IC7A Q13164 46 400 816.0 ANP:60501 ATPlike Inactive DFGin 6.963 15.707 BLAminus -112.54, -170.45 61.6, 71.09 -94.22, 5.13 285.3, 80.28 -60.77, -23.83 in-in in 9.45 Saltbr-in 2.911 HRD-in -64.26, -48.71 75.06, -19.07 in-in-out SNCiio in-out ActLoopNT-in 3.184 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na 163.57, 152.54 APE9-dihe-na -166.15, 155.73 APE8-dihe-in -57.6, 140.19 APE8-rot-out 163.75 APE67-dihe-in -65.59, -38.02 -73.56, -13.59 APE12-dist-in 8.83 APE11-dist-out 6.338 APE10-dist-out 8.509 APE9-dist-in 5.809 None None None XRAY 2.6 0.213 0.258 A 442 355 0 0 0 0 [[55, 347]] 1.0 4ic7 CMGC_MAPK7_HUMAN CMGC 1.4e-81 280.1 1 301 301 199 200 201 203 205 84 102 106 179 181 180 182 244 231 226 225 224 223 222 221 220 138 Mitogen-activated protein kinase 7
CMGC MAPK7 MK07_HUMAN 4IC7D Q13164 47 399 816.0 ANP:60501 ATPlike Inactive DFGin 6.921 15.491 BLAminus -111.52, -167.35 56.73, 75.91 -99.28, 4.79 286.66, 84.61 -57.3, -28.24 in-in in 9.382 Saltbr-in 3.274 HRD-in -69.27, -53.54 75.02, -19.96 in-in-out SNCiio in-out ActLoopNT-in 3.043 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -103.14, 107.5 APE9-dihe-na -135.73, 156.83 APE8-dihe-in -63.07, 155.1 APE8-rot-out 142.76 APE67-dihe-in -57.29, -43.39 -78.84, -17.33 APE12-dist-in 8.83 APE11-dist-out 6.981 APE10-dist-out 8.351 APE9-dist-in 5.57 None None None XRAY 2.6 0.213 0.258 D 442 353 0 0 0 0 [[55, 347]] 1.0 4ic7 CMGC_MAPK7_HUMAN CMGC 1.4e-81 280.1 1 301 301 199 200 201 203 205 84 102 106 179 181 180 182 244 231 226 225 224 223 222 221 220 138 Mitogen-activated protein kinase 7
CMGC MAPK8 MK08_HUMAN 6ZR5A P45983 3 362 427.0 ANP:60402 ATPlike Inactive DFGin 3.817 14.226 ABAminus -84.03, -42.55 -114.88, 174.79 -114.82, 8.54 299.13, 101.86 79.5, -168.62 out-out out 10.002 Saltbr-out 5.031 HRD-in -56.29, -55.44 70.4, -2.27 out-out-out SNCooo out-out ActLoopNT-out 6.872 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 107.14 APE8-rot-out 87.08 APE67-dihe-in -67.28, -21.26 -101.91, 26.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.699 0.186 0.256 A 366 348 12 0 0 12 [[26, 321]] 1.0 6zr5 CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 6ZR5B P45983 4 362 427.0 ANP:60400 ATPlike Inactive DFGin 3.867 14.072 ABAminus -85.51, -41.13 -110.19, 172.79 -115.96, 8.05 294.61, 92.39 79.48, -170.78 out-out out 10.021 Saltbr-out 4.224 HRD-in -59.93, -50.9 67.15, -3.15 out-out-out SNCooo out-out ActLoopNT-out 6.849 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -100.6, 89.98 APE9-dihe-na -140.16, 151.66 APE8-dihe-in -87.57, 109.71 APE8-rot-in 298.46 APE67-dihe-in -73.45, -13.54 -100.12, 16.22 APE12-dist-out 17.551 APE11-dist-in 12.898 APE10-dist-out 16.341 APE9-dist-out 11.496 None None None XRAY 2.699 0.186 0.256 B 366 359 0 0 0 0 [[26, 321]] 1.0 6zr5 CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 2XRWA P45983 2 364 427.0 ANP:61367 ATPlike Inactive DFGin 3.816 13.941 ABAminus -85.3, -24.5 -153.59, -177.02 -115.68, 7.02 304.14, 97.05 88.01, -156.78 in-out in 9.886 Saltbr-out 4.635 HRD-in -83.3, -58.4 77.36, -14.29 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.45, -23.57 999.0, -3.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.33 0.166 0.187 A 371 347 16 0 0 16 [[26, 321]] 1.0 2xrw CMGC_MAPK8_HUMAN CMGC 8.5e-85 290.5 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 2XS0A P45983 6 365 427.0 ANP:1367 ATPlike Inactive DFGin 3.754 14.081 ABAminus -75.25, -22.88 -148.14, -178.22 -116.01, 26.92 303.04, 86.85 61.81, -161.42 in-out in 9.735 Saltbr-out 5.55 HRD-in -69.33, -60.51 78.49, -20.02 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 173.45 APE8-rot-out 188.87 APE67-dihe-out -73.26, -26.46 -135.55, 95.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T183V,Y185F None None XRAY 2.6 0.194 0.246 A 386 346 14 0 0 14 [[26, 321]] 1.0 2xs0 CMGC_MAPK8_HUMAN CMGC 4.5e-83 284.9 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 4UX9A P45983 8 363 427.0 ANP:1000 ATPlike Inactive DFGin 6.508 13.598 ABAminus -106.9, -65.56 -75.5, 125.74 -123.36, 16.47 304.33, 124.23 -68.62, -34.25 in-out in 8.85 Saltbr-out 3.673 HRD-in -62.88, -46.37 73.76, -28.18 out-in-in SNCoii in-in ActLoopNT-in 2.694 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -77.3, -23.46 APE9-dihe-na -71.58, 140.2 APE8-dihe-in -64.86, 127.48 APE8-rot-in 308.5 APE67-dihe-in -60.43, -26.76 -33.69, -61.49 APE12-dist-in 11.784 APE11-dist-in 12.426 APE10-dist-in 6.631 APE9-dist-in 4.533 None None None XRAY 2.34 0.202 0.24 A 364 343 7 0 0 5 [[26, 321]] 1.0 4ux9 CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 4UX9C P45983 8 363 427.0 ANP:1000 ATPlike Inactive DFGin 6.956 13.776 ABAminus -110.49, -64.95 -89.1, 120.63 -119.14, 21.23 309.02, 115.06 -68.23, -26.49 in-out in 8.919 Saltbr-out 3.636 HRD-in -66.22, -47.15 71.23, -16.82 out-in-none SNCoin in-none ActLoopNT-in 2.569 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -79.69, -26.4 APE9-dihe-na -76.07, 142.18 APE8-dihe-in -66.37, 127.01 APE8-rot-in 305.02 APE67-dihe-in -64.57, -24.76 -35.27, -55.26 APE12-dist-none 999.0 APE11-dist-in 12.005 APE10-dist-in 6.53 APE9-dist-in 4.621 None None None XRAY 2.34 0.202 0.24 C 364 333 15 0 0 7 [[26, 321]] 1.0 4ux9 CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 4UX9D P45983 9 364 427.0 ANP:1000 ATPlike Inactive DFGin 6.755 13.406 ABAminus -120.6, -55.98 -93.07, 108.1 -98.68, 25.97 301.07, 117.04 -64.8, -33.9 in-in in 9.366 Saltbr-in 2.738 HRD-in -59.8, -49.61 70.57, -12.64 in-in-out SNCiio in-out ActLoopNT-in 2.67 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oioo APE10-dihe-na -95.31, 105.19 APE9-dihe-na -74.34, -56.46 APE8-dihe-in -76.71, 134.72 APE8-rot-out 95.68 APE67-dihe-out -66.63, -26.9 -139.86, 50.27 APE12-dist-out 14.031 APE11-dist-in 13.438 APE10-dist-out 10.823 APE9-dist-out 13.555 None None None XRAY 2.34 0.202 0.24 D 364 344 9 0 0 0 [[26, 321]] 1.0 4ux9 CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 8R5EA P45983 5 363 427.0 ANP:402,Y6K:403 ATPlike,Allosteric Inactive DFGin 4.215 13.884 ABAminus -92.07, -26.65 -133.67, 178.16 -123.93, 6.5 294.94, 97.33 89.15, -162.77 in-out in 9.521 Saltbr-out 4.842 HRD-in -77.17, -59.97 76.05, -10.25 out-out-out SNCooo out-out ActLoopNT-out 6.79 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -62.14, 143.17 APE9-dihe-na -120.32, 118.65 APE8-dihe-in -75.39, 123.94 APE8-rot-in 299.29 APE67-dihe-in -61.41, -23.9 -115.12, 4.11 APE12-dist-out 18.707 APE11-dist-out 15.325 APE10-dist-out 16.68 APE9-dist-out 11.244 None None None XRAY 1.7 0.177 0.222 A 366 359 0 0 0 0 [[26, 321]] 1.0 8r5e CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 4QTDA P45983 6 363 427.0 38Z:424,ANP:425 Type1,Allosteric Inactive DFGin 4.279 13.95 ABAminus -89.69, -21.2 -135.34, 171.77 -115.48, 9.24 298.02, 89.8 87.52, -156.74 in-out in 9.593 Saltbr-out 4.153 HRD-in -75.36, -55.62 72.51, -12.26 out-out-out SNCooo out-out ActLoopNT-out 6.689 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -117.32, 137.81 APE9-dihe-na -80.42, 132.23 APE8-dihe-in -83.54, 120.1 APE8-rot-in 296.41 APE67-dihe-in -61.39, -20.52 -109.55, -3.05 APE12-dist-out 21.14 APE11-dist-out 16.032 APE10-dist-out 16.517 APE9-dist-out 11.147 None None None XRAY 1.5 0.167 0.192 A 364 355 3 0 0 3 [[26, 321]] 1.0 4qtd CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 9FT9A P45983 7 363 427.0 ANP:401 ATPlike Inactive DFGin 6.201 13.681 BLAminus -138.37, -170.04 58.94, 78.24 -92.66, 22.82 315.32, 103.73 -63.89, -26.18 in-out in 8.542 Saltbr-out 3.842 HRD-in -66.92, -47.02 65.13, 0.51 out-in-out SNCoio in-out ActLoopNT-in 2.827 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -150.17, 156.5 APE9-dihe-na -75.27, -52.01 APE8-dihe-in -88.35, 100.07 APE8-rot-in 310.81 APE67-dihe-in -64.72, -11.39 -102.84, 1.94 APE12-dist-out 5.91 APE11-dist-in 10.581 APE10-dist-out 8.079 APE9-dist-out 10.949 None None None XRAY 2.35 0.234 0.27 A 360 357 0 0 0 0 [[26, 321]] 1.0 9ft9 CMGC_MAPK8_HUMAN CMGC 4.1e-84 288.2 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 4UX9B P45983 8 362 427.0 ANP:1000 ATPlike Inactive DFGin 6.827 14.001 None -95.23, -79.97 -82.17, 124.02 -113.22, 13.68 297.81, 107.19 -60.29, -32.64 in-in in 8.603 Saltbr-in 2.942 HRD-in -59.44, -53.0 79.08, -24.85 in-in-in SNCiii in-in ActLoopNT-in 2.582 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -58.47, -40.48 APE9-dihe-na -78.17, 138.93 APE8-dihe-in -64.59, 122.35 APE8-rot-in 308.57 APE67-dihe-in -67.83, -19.56 -32.59, -57.13 APE12-dist-in 12.361 APE11-dist-in 12.149 APE10-dist-in 6.527 APE9-dist-in 4.691 None None None XRAY 2.34 0.202 0.24 B 364 327 14 0 0 6 [[26, 321]] 1.0 4ux9 CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC PRP4K PRP4K_HUMAN 4IIRA Q13523 668 1005 1007.0 ANP:1101 ATPlike Inactive DFGin 6.315 14.281 BLAminus -120.02, 179.88 56.46, 83.55 -99.74, 23.13 289.68, 86.8 -67.87, -30.41 in-in in 8.339 Saltbr-in 2.91 HRD-in -69.64, -43.63 60.41, 19.82 in-in-out SNCiio in-out ActLoopNT-in 2.778 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -71.08, 135.09 APE9-dihe-na 76.0, 140.17 APE8-dihe-in -53.9, 125.75 APE8-rot-in 292.63 APE67-dihe-in -65.92, -24.69 -31.89, -51.26 APE12-dist-out 15.663 APE11-dist-in 11.805 APE10-dist-out 8.892 APE9-dist-in 3.194 None PTR849 PTR849 XRAY 2.0 0.244 0.265 A 358 326 12 0 0 0 [[687, 1003]] 1.0 4iir CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
CMGC PRP4K PRP4K_HUMAN 4IIRB Q13523 670 1005 1007.0 ANP:1101 ATPlike Inactive DFGin 6.312 13.999 BLAminus -118.84, -178.78 57.41, 86.51 -103.95, 25.37 293.04, 89.03 -68.57, -33.53 in-in in 8.481 Saltbr-in 2.795 HRD-in -68.12, -42.18 57.06, 24.08 in-in-out SNCiio in-out ActLoopNT-in 2.804 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -73.62, 140.27 APE9-dihe-na 75.42, 141.56 APE8-dihe-in -56.4, 124.9 APE8-rot-in 292.41 APE67-dihe-in -64.45, -24.58 -31.45, -51.6 APE12-dist-out 15.602 APE11-dist-in 11.812 APE10-dist-out 8.604 APE9-dist-in 3.219 None PTR849 PTR849 XRAY 2.0 0.244 0.265 B 358 328 8 0 0 0 [[687, 1003]] 1.0 4iir CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
CMGC SRPK1 SRPK1_HUMAN 3BEGA Q96SB4 69 655 655.0 ANP:656 ATPlike Inactive DFGin 5.24 13.846 BLAminus -114.77, -153.39 33.98, 76.85 -81.15, -2.34 268.31, 108.69 -69.77, 18.55 in-none in 9.999 Saltbr-none 999.0 HRD-in -104.12, -37.12 72.24, -11.76 none-in-out SNCnio in-out ActLoopNT-in 3.285 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -116.54, 166.61 APE9-dihe-na 69.15, 140.92 APE8-dihe-in -77.27, 142.01 APE8-rot-out 16.0 APE67-dihe-in -60.83, 1.46 -31.99, -68.49 APE12-dist-in 12.995 APE11-dist-in 10.441 APE10-dist-in 7.835 APE9-dist-in 3.062 None None None XRAY 2.9 0.24 0.298 A 381 348 21 0 0 0 [[80, 653]] 1.0 3beg CMGC_SRPK1_HUMAN CMGC 1.7e-139 470.1 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
OTHER EIF2AK2 E2AK2_HUMAN 2A19B P19525 258 541 551.0 ANP:61640 ATPlike Inactive DFGin 6.285 14.335 ABAminus -120.94, -28.83 -115.8, 107.84 -103.04, 22.08 287.72, 80.44 -61.97, -26.4 in-in in 8.248 Saltbr-in 2.731 HRD-in -80.45, -51.29 75.68, -7.45 in-in-out SNCiio in-out ActLoopNT-in 3.061 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -131.92, 139.76 APE9-dihe-na 107.67, -147.72 APE8-dihe-in -73.7, 128.56 APE8-rot-out 9.97 APE67-dihe-in -50.1, -40.95 -103.24, -6.7 APE12-dist-in 12.545 APE11-dist-in 10.841 APE10-dist-out 10.336 APE9-dist-out 9.852 H412N,C551A TPO446 TPO446 XRAY 2.5 0.234 0.286 B 284 262 9 0 0 0 [[175, 537]] 1.0 2a19 OTHER_EIF2AK2_HUMAN OTHER 6.2e-47 166.4 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 2A19C P19525 258 541 551.0 ANP:62640 ATPlike Inactive DFGin 6.941 14.558 ABAminus -118.27, -31.05 -99.56, 112.7 -116.24, 24.93 286.16, 84.97 -61.15, -35.53 in-in in 7.696 Saltbr-in 3.422 HRD-out -95.69, 102.36 -63.67, -30.07 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 H412N,C551A TPO446 TPO446 XRAY 2.5 0.234 0.286 C 284 202 69 0 0 22 [[175, 537]] 1.0 2a19 OTHER_EIF2AK2_HUMAN OTHER 6.2e-47 166.4 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER TP53RK PRPK_HUMAN 6WQXC Q96S44 17 247 253.0 ANP:301 ATPlike Active DFGin 5.95 14.251 BLAminus -146.19, 177.42 55.9, 80.94 -109.82, 15.46 288.95, 83.65 -50.48, -21.92 in-in in 7.493 Saltbr-in 2.923 HRD-in -69.98, -47.0 96.04, -14.43 in-in-na SNCiia in-na ActLoopNT-in 2.804 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -67.54, -42.02 APE9-dihe-na -66.2, -40.19 APE8-dihe-na -55.79, -43.62 APE8-rot-na 183.14 APE67-dihe-na -65.72, -35.03 -54.78, -48.19 APE12-dist-na 16.724 APE11-dist-na 12.036 APE10-dist-na 14.577 APE9-dist-na 11.741 None None None XRAY 2.53 0.214 0.265 C 267 231 6 0 0 0 [[32, 253]] 1.0 6wqx OTHER_TP53RK_HUMAN TP53RK 1.2e-114 387.3 1 224 224 182 183 184 186 188 60 84 88 159 161 160 162 199 205 200 199 198 197 196 195 194 114 EKC/KEOPS complex subunit TP53RK
OTHER TP53RK PRPK_HUMAN 6WQXD Q96S44 18 247 253.0 ANP:301 ATPlike Active DFGin 6.043 14.258 BLAminus -133.24, 171.19 66.42, 73.64 -108.34, 16.47 289.91, 91.17 -66.2, -15.73 in-in in 7.377 Saltbr-in 2.505 HRD-in -60.03, -49.96 100.64, -20.8 in-in-na SNCiia in-na ActLoopNT-in 2.816 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -66.35, -39.45 APE9-dihe-na -58.51, -49.84 APE8-dihe-na -58.36, -37.8 APE8-rot-na 168.78 APE67-dihe-na -71.45, -37.84 -63.19, -40.46 APE12-dist-na 16.676 APE11-dist-na 12.07 APE10-dist-na 14.499 APE9-dist-na 11.469 None None None XRAY 2.53 0.214 0.265 D 267 230 6 0 0 0 [[32, 253]] 1.0 6wqx OTHER_TP53RK_HUMAN TP53RK 1.2e-114 387.3 1 224 224 182 183 184 186 188 60 84 88 159 161 160 162 199 205 200 199 198 197 196 195 194 114 EKC/KEOPS complex subunit TP53RK
OTHER WNK1 WNK1_HUMAN 5WDYA Q9H4A3 208 481 2382.0 ANP:901,A6S:902 ATPlike,Type3 None DFGin 7.965 14.31 BLAminus -123.5, -167.41 55.36, 79.67 -97.29, 28.92 280.94, 63.73 -64.29, -44.25 na-na na 15.412 Saltbr-na 999.0 HRD-in -68.16, -49.86 71.58, -14.71 na-in-none SNCain in-none ActLoopNT-in 3.014 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -108.13, -60.96 999.0, 157.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S378D,E396A,E397A,K398A None None XRAY 2.458 0.231 0.285 A 279 260 14 0 0 9 [[220, 479]] 1.0 5wdy OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1 260 260 367 368 369 371 373 250 268 272 346 348 347 349 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 5WDYB Q9H4A3 206 480 2382.0 ANP:502,A6S:503 ATPlike,Type3 Inactive DFGin 7.37 14.504 BLAminus -142.95, -168.2 54.59, 81.56 -95.94, 38.03 311.01, 0.7 -70.23, -38.22 na-na na 15.664 Saltbr-na 999.0 HRD-in -73.48, -49.35 66.41, -10.51 na-in-out SNCaio in-out ActLoopNT-in 2.856 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -28.04 APE8-rot-out 62.13 APE67-dihe-out -96.17, -54.53 -53.63, 160.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S378D,E396A,E397A,K398A None None XRAY 2.458 0.231 0.285 B 279 259 16 0 0 9 [[220, 479]] 1.0 5wdy OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1 260 260 367 368 369 371 373 250 268 272 346 348 347 349 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 5WE8A Q9H4A3 209 483 2382.0 ANP:502,A7Y:503 ATPlike,Type3 Inactive DFGin 7.241 14.032 BLAminus -121.41, -171.4 57.02, 71.32 -89.03, 25.94 306.74, 15.86 -67.83, -33.81 na-na na 15.506 Saltbr-na 999.0 HRD-in -66.1, -48.39 70.94, -12.37 na-in-out SNCaio in-out ActLoopNT-in 2.847 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -77.54, 145.45 APE9-dihe-na 132.01, 166.25 APE8-dihe-in -145.73, 139.85 APE8-rot-out 178.66 APE67-dihe-out -92.59, -40.75 -69.19, 149.7 APE12-dist-out 20.134 APE11-dist-out 22.408 APE10-dist-out 25.402 APE9-dist-out 25.928 S378D,E396A,E397A,K398A None None XRAY 2.006 0.205 0.247 A 279 270 5 0 0 0 [[220, 479]] 1.0 5we8 OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1 260 260 367 368 369 371 373 250 268 272 346 348 347 349 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 5WE8B Q9H4A3 207 480 2382.0 ANP:502,A7Y:503 ATPlike,Type3 Inactive DFGin 7.576 14.733 BLAminus -124.5, -174.3 56.61, 76.82 -93.57, 20.89 272.49, 56.06 -64.65, -35.23 na-na na 15.252 Saltbr-na 999.0 HRD-in -64.68, -49.22 72.3, -10.07 na-in-out SNCaio in-out ActLoopNT-in 2.82 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -86.7, 136.01 APE9-dihe-na 147.23, 150.88 APE8-dihe-in -131.74, 126.21 APE8-rot-in 297.77 APE67-dihe-out -91.94, -28.57 -59.79, 145.49 APE12-dist-out 19.935 APE11-dist-out 22.726 APE10-dist-out 25.875 APE9-dist-out 25.614 S378D,E396A,E397A,K398A None None XRAY 2.006 0.205 0.247 B 279 272 2 0 0 0 [[220, 479]] 1.0 5we8 OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1 260 260 367 368 369 371 373 250 268 272 346 348 347 349 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 5TF9A Q9H4A3 210 483 2382.0 7AV:501,ANP:502 Type3,ATPlike Inactive DFGin 7.799 14.806 BLAminus -124.68, -165.52 44.5, 74.88 -89.64, 28.71 274.12, 71.89 -66.6, -24.41 na-na na 15.637 Saltbr-na 999.0 HRD-in -62.68, -52.45 73.71, -6.51 na-in-out SNCaio in-out ActLoopNT-in 2.868 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 175.52 APE8-dihe-in -127.14, 129.36 APE8-rot-out 176.04 APE67-dihe-out -84.82, -53.84 -65.86, 145.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 27.092 None None None XRAY 2.5 0.198 0.266 A 279 262 12 0 0 9 [[220, 479]] 1.0 5tf9 OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1 260 260 367 368 369 371 373 250 268 272 346 348 347 349 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 5TF9B Q9H4A3 206 480 2382.0 7AV:501,ANP:502 Type3,ATPlike Inactive DFGin 7.745 14.581 BLAminus -133.01, -172.41 51.04, 69.52 -83.58, 20.61 265.53, 72.73 -66.77, -27.15 na-na na 14.861 Saltbr-na 999.0 HRD-in -69.24, -45.67 70.25, -7.52 na-in-out SNCaio in-out ActLoopNT-in 2.902 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -166.32 APE8-dihe-in -143.09, 133.87 APE8-rot-in 278.07 APE67-dihe-out -99.53, -28.5 -65.98, 144.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 26.599 None None None XRAY 2.5 0.198 0.266 B 279 266 9 0 0 9 [[220, 479]] 1.0 5tf9 OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1 260 260 367 368 369 371 373 250 268 272 346 348 347 349 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK3 WNK3_HUMAN 5O26A Q9BYP7 135 414 1800.0 ANP:501 ATPlike Active DFGin 6.954 12.201 BLAminus -125.28, -164.72 58.79, 65.89 -88.2, 18.66 305.61, 176.73 -69.56, -20.03 na-na na 15.898 Saltbr-na 999.0 HRD-in -66.1, -48.87 66.45, 11.22 na-in-in SNCaii in-in ActLoopNT-in 3.021 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.2, 167.0 APE9-dihe-na 127.63, -163.54 APE8-dihe-in -104.53, 119.98 APE8-rot-in 309.3 APE67-dihe-in -64.09, -19.44 -52.49, -34.59 APE12-dist-in 8.873 APE11-dist-in 11.829 APE10-dist-in 6.326 APE9-dist-in 3.706 None SEP304,SEP308 SEP304,SEP308 XRAY 2.379 0.231 0.278 A 284 273 7 0 0 0 [[146, 405]] 1.0 5o26 OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
OTHER WNK3 WNK3_HUMAN 5O26B Q9BYP7 136 413 1800.0 ANP:501 ATPlike Active DFGin 7.182 12.078 BLAminus -111.0, -167.63 57.49, 63.76 -86.7, 17.71 307.84, 173.05 -70.2, -27.96 na-na na 15.641 Saltbr-na 999.0 HRD-in -66.99, -53.82 74.22, 8.4 na-in-in SNCaii in-in ActLoopNT-in 3.073 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.41, 145.08 APE9-dihe-na 140.9, -162.45 APE8-dihe-in -99.46, 120.61 APE8-rot-in 305.94 APE67-dihe-in -65.71, -19.72 -54.06, -31.08 APE12-dist-in 8.136 APE11-dist-in 11.827 APE10-dist-in 6.044 APE9-dist-in 3.51 None SEP304,SEP308 SEP304,SEP308 XRAY 2.379 0.231 0.278 B 284 267 11 0 0 0 [[146, 405]] 1.0 5o26 OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
STE MAP2K1 MP2K1_HUMAN 5YT3C Q02750 40 382 393.0 ANP:401 ATPlike Inactive DFGin 5.791 13.739 BLBplus -158.87, 169.48 60.29, 28.47 -79.68, 102.42 54.67, 117.74 -64.84, 999.0 out-none out 15.495 Saltbr-none 999.0 HRD-in -68.06, -45.57 70.46, -13.87 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 133.64 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S218D,S222D,T292A,S298A None None XRAY 2.9 0.213 0.289 C 350 288 55 0 0 17 [[68, 361]] 1.0 5yt3 STE_MAP2K1_HUMAN STE 4.7e-97 330.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 6V2WB Q02750 40 383 393.0 ANP:801 ATPlike Inactive DFGin 5.839 13.801 BLBplus -157.59, 169.08 49.06, 44.93 -84.24, 160.32 41.65, 89.8 -73.89, 81.99 out-out out 15.498 Saltbr-out 15.901 HRD-in -69.45, -57.02 68.3, 7.65 out-out-out SNCooo out-out ActLoopNT-out 8.701 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -54.4, 144.31 APE9-dihe-na -89.17, -161.86 APE8-dihe-out -115.14, -20.62 APE8-rot-out 48.82 APE67-dihe-out -139.36, 135.26 -146.31, 162.2 APE12-dist-out 17.533 APE11-dist-out 22.736 APE10-dist-out 24.016 APE9-dist-out 13.645 S218A,S222A None None XRAY 3.12 0.189 0.237 B 397 312 32 0 0 0 [[68, 361]] 1.0 6v2w STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3SLSA Q02750 45 383 393.0 ANP:60400,77D:60500 ATPlike,Type3 Inactive DFGin 6.067 13.828 BLBplus -140.19, 178.66 54.09, 43.7 -94.25, 127.95 47.57, 97.28 -65.93, 145.27 out-out out 15.765 Saltbr-out 16.219 HRD-in -71.97, -60.22 78.51, -3.12 out-out-out SNCooo out-out ActLoopNT-out 8.437 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nooo APE10-dihe-na -93.38, -0.96 APE9-dihe-na -118.58, -150.08 APE8-dihe-out -118.64, -9.13 APE8-rot-out 48.38 APE67-dihe-out -141.57, 136.87 -142.17, 156.77 APE12-dist-none 999.0 APE11-dist-out 20.727 APE10-dist-out 20.295 APE9-dist-out 13.917 None None None XRAY 2.3 0.21 0.287 A 304 288 7 0 0 6 [[68, 361]] 1.0 3sls STE_MAP2K1_HUMAN STE 1.4e-98 335.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3SLSB Q02750 45 383 393.0 ANP:60400,77D:60500 ATPlike,Type3 Inactive DFGin 6.221 13.815 BLBplus -143.68, 175.58 56.27, 41.79 -94.32, 130.27 43.79, 91.06 -64.4, 146.65 out-out out 15.816 Saltbr-out 15.927 HRD-in -71.99, -58.98 74.88, -1.55 out-out-out SNCooo out-out ActLoopNT-out 7.506 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nooo APE10-dihe-na -110.34, -17.81 APE9-dihe-na 107.94, -164.16 APE8-dihe-out -114.29, -25.66 APE8-rot-out 168.01 APE67-dihe-out -146.37, 136.37 -123.32, 171.0 APE12-dist-none 999.0 APE11-dist-out 19.137 APE10-dist-out 21.303 APE9-dist-out 13.595 None None None XRAY 2.3 0.21 0.287 B 304 290 5 0 0 5 [[68, 361]] 1.0 3sls STE_MAP2K1_HUMAN STE 1.4e-98 335.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B3MA Q02750 37 382 393.0 ANP:60402,SU5:60403 ATPlike,Type3 Inactive DFGin 6.126 13.37 BLBplus -148.65, 168.81 60.69, 38.17 -87.91, 154.07 39.86, 88.52 -71.49, 59.19 out-out out 15.314 Saltbr-out 14.994 HRD-in -70.73, -50.42 71.08, -9.53 out-out-out SNCooo out-out ActLoopNT-out 8.955 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -121.3 APE8-dihe-out -86.65, -7.6 APE8-rot-out 192.68 APE67-dihe-out -130.89, 138.61 -149.99, 133.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.675 None None None XRAY 2.3 0.22 0.268 A 326 297 5 0 0 5 [[68, 361]] 1.0 7b3m STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B3MB Q02750 37 382 393.0 ANP:60402,SU5:60403 ATPlike,Type3 Inactive DFGin 6.095 13.35 BLBplus -147.84, 168.76 59.95, 38.27 -86.94, 152.02 37.7, 89.9 -70.97, 59.7 out-out out 15.264 Saltbr-out 14.844 HRD-in -70.51, -50.26 71.48, -11.7 out-out-out SNCooo out-out ActLoopNT-out 8.913 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -133.25 APE8-dihe-out -83.19, -28.76 APE8-rot-in 262.25 APE67-dihe-out -150.63, 137.62 -127.52, 158.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.084 None None None XRAY 2.3 0.22 0.268 B 326 298 4 0 0 4 [[68, 361]] 1.0 7b3m STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B7RA Q02750 37 382 393.0 ANP:60401,T1K:60403 ATPlike,Type3 Inactive DFGin 6.142 13.168 BLBplus -135.79, 174.07 60.45, 39.3 -91.52, 155.87 43.71, 91.25 -77.25, 65.03 out-out out 15.299 Saltbr-out 15.464 HRD-in -68.45, -57.29 78.52, -6.73 out-out-out SNCooo out-out ActLoopNT-out 8.935 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -104.92 APE8-dihe-out -68.21, -24.42 APE8-rot-out 184.14 APE67-dihe-out -122.45, 137.43 -138.43, 139.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.332 None None None XRAY 1.7 0.195 0.218 A 326 297 5 0 0 5 [[68, 361]] 1.0 7b7r STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B7RB Q02750 39 382 393.0 ANP:60401,T1K:60403 ATPlike,Type3 Inactive DFGin 6.034 13.131 BLBplus -135.72, 177.16 59.39, 36.14 -85.12, 154.58 37.29, 94.77 -80.68, 71.22 out-out out 15.295 Saltbr-out 15.378 HRD-in -70.94, -55.67 77.08, -4.68 out-out-out SNCooo out-out ActLoopNT-out 8.9 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -49.75 APE8-rot-out 171.35 APE67-dihe-out -144.02, 141.19 -140.4, 157.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.195 0.218 B 326 295 5 0 0 5 [[68, 361]] 1.0 7b7r STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B94A Q02750 37 382 393.0 ANP:60401,T3W:60403 ATPlike,Type3 Inactive DFGin 5.992 13.478 BLBplus -132.63, 177.07 57.77, 37.37 -87.97, 156.39 42.38, 94.42 -75.9, 68.49 out-out out 15.532 Saltbr-out 15.193 HRD-in -65.24, -55.1 71.13, -2.53 out-out-out SNCooo out-out ActLoopNT-out 8.887 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 176.47 APE8-dihe-out -89.38, 6.07 APE8-rot-in 312.59 APE67-dihe-out -115.47, 140.44 -116.58, 113.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.599 None None None XRAY 2.0 0.218 0.265 A 326 297 5 0 0 5 [[68, 361]] 1.0 7b94 STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B94B Q02750 41 382 393.0 ANP:60401,T3W:60403 ATPlike,Type3 Inactive DFGin 5.853 13.51 BLBplus -134.32, 175.36 55.61, 39.25 -86.46, 153.65 39.68, 92.62 -72.74, 66.29 out-out out 15.117 Saltbr-out 14.548 HRD-in -66.3, -53.58 77.63, -11.98 out-out-out SNCooo out-out ActLoopNT-out 8.617 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -40.61 APE8-rot-out 185.17 APE67-dihe-out -147.87, 139.4 -127.59, 154.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.218 0.265 B 326 293 5 0 0 5 [[68, 361]] 1.0 7b94 STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B9LA Q02750 37 382 393.0 ANP:60401,T4N:60402 ATPlike,Type3 Inactive DFGin 6.143 13.385 BLBplus -137.56, 174.87 57.48, 45.06 -95.99, 156.93 43.03, 91.55 -78.34, 66.31 out-out out 15.272 Saltbr-out 15.243 HRD-in -67.86, -56.92 79.15, -7.52 out-out-none SNCoon out-none ActLoopNT-out 8.968 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -119.38, 141.01 999.0, 135.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.194 0.214 A 326 295 7 0 0 7 [[68, 361]] 1.0 7b9l STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B9LB Q02750 41 381 393.0 ANP:60401,T4N:60402 ATPlike,Type3 Inactive DFGin 5.958 13.456 BLBplus -136.66, 175.43 56.67, 43.08 -92.39, 158.5 42.85, 91.66 -74.84, 62.99 out-out out 15.156 Saltbr-out 14.936 HRD-in -69.72, -56.61 80.29, -8.28 out-out-none SNCoon out-none ActLoopNT-out 8.692 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -146.85, 137.07 999.0, 132.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.194 0.214 B 326 291 6 0 0 6 [[68, 361]] 1.0 7b9l STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3ORNA Q02750 62 380 393.0 ANP:60001,3OR:60400 ATPlike,Type3 Inactive DFGin 6.029 13.804 BLBplus -141.26, -171.81 51.14, 43.91 -94.56, 165.92 40.22, 96.28 -82.7, 73.49 out-out out 15.345 Saltbr-out 15.245 HRD-in -75.72, -51.63 76.11, -2.33 out-out-out SNCooo out-out ActLoopNT-out 9.248 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -90.01, 161.45 APE9-dihe-na 75.09, 172.06 APE8-dihe-out -101.08, -27.15 APE8-rot-out 71.34 APE67-dihe-out -133.03, 139.32 -108.61, 153.73 APE12-dist-out 16.856 APE11-dist-out 20.622 APE10-dist-out 18.566 APE9-dist-out 13.045 None None None XRAY 2.8 0.236 0.277 A 307 279 8 0 0 0 [[68, 361]] 1.0 3orn STE_MAP2K1_HUMAN STE 9.7e-99 335.8 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3WIGA Q02750 62 380 393.0 ANP:60401,CHU:60403 ATPlike,Type3 Inactive DFGin 6.265 14.016 BLBplus -143.18, 168.24 57.0, 43.27 -87.61, 167.58 35.17, 91.44 -81.11, 80.9 out-out out 15.223 Saltbr-out 15.235 HRD-in -81.12, -52.72 78.66, -9.66 out-out-out SNCooo out-out ActLoopNT-out 9.252 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -106.56, 160.96 APE9-dihe-na 79.87, 168.49 APE8-dihe-out -95.77, -24.16 APE8-rot-out 58.57 APE67-dihe-out -134.06, 137.9 -112.83, 153.13 APE12-dist-out 16.507 APE11-dist-out 20.149 APE10-dist-out 18.501 APE9-dist-out 12.948 None None None XRAY 2.7 0.217 0.25 A 307 277 10 0 0 0 [[68, 361]] 1.0 3wig STE_MAP2K1_HUMAN STE 9.7e-99 335.8 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4U80A Q02750 62 379 393.0 ANP:60501,3EX:60502 ATPlike,Type3 Inactive DFGin 6.142 13.358 BLBplus -137.92, -179.3 57.25, 41.8 -100.21, 164.46 49.55, 87.81 -82.1, 69.9 out-out out 15.391 Saltbr-out 16.174 HRD-in -63.5, -60.19 86.1, -12.96 out-out-out SNCooo out-out ActLoopNT-out 9.174 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnoo APE10-dihe-na 999.0, -56.89 APE9-dihe-na 91.88, -152.59 APE8-dihe-out -126.68, 10.89 APE8-rot-in 310.84 APE67-dihe-out -98.05, 140.26 -155.43, 115.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.557 APE9-dist-out 13.427 None None None XRAY 2.8 0.167 0.224 A 341 285 33 0 0 3 [[68, 361]] 1.0 4u80 STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4LMNA Q02750 62 382 393.0 ANP:60501,EUI:60503 ATPlike,Type3 Inactive DFGin 6.109 13.407 BLBplus -150.33, -178.45 56.52, 30.25 -84.69, 155.37 45.37, 87.33 -80.58, 74.43 out-out out 15.56 Saltbr-out 15.776 HRD-in -60.71, -57.05 86.56, -12.8 out-out-out SNCooo out-out ActLoopNT-out 9.013 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -106.36, -106.55 APE9-dihe-na -110.69, -4.9 APE8-dihe-out -94.39, -2.53 APE8-rot-out 38.79 APE67-dihe-out -120.37, 128.01 -144.86, 111.2 APE12-dist-out 20.474 APE11-dist-out 19.732 APE10-dist-out 22.049 APE9-dist-out 15.311 None None None XRAY 2.8 0.193 0.233 A 341 291 30 0 0 0 [[68, 361]] 1.0 4lmn STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7UMBC Q02750 41 381 393.0 ANP:401,U9F:402 ATPlike,Type3 Inactive DFGin 6.169 13.767 BLBplus -162.24, 171.11 70.21, 49.7 -113.95, 160.88 44.65, 94.08 -79.06, 81.13 out-out out 15.559 Saltbr-out 15.273 HRD-in -66.12, -48.09 76.83, -9.86 out-out-out SNCooo out-out ActLoopNT-out 9.591 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -127.94, 139.36 APE9-dihe-na -138.86, -160.81 APE8-dihe-out -82.2, -18.64 APE8-rot-out 50.9 APE67-dihe-out -106.39, 139.13 -104.8, 110.61 APE12-dist-out 16.699 APE11-dist-out 19.666 APE10-dist-out 21.57 APE9-dist-out 14.915 None None None XRAY 3.231 0.231 0.268 C 384 303 38 0 0 0 [[68, 361]] 1.0 7umb STE_MAP2K1_HUMAN STE 2.3e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 6PP9B Q02750 38 383 393.0 ANP:801,LCJ:803 ATPlike,Type3 Inactive DFGin 6.051 13.85 BLBplus -152.52, 171.62 57.53, 41.01 -92.48, 164.33 45.1, 87.01 -81.4, 67.83 out-out out 15.469 Saltbr-out 15.325 HRD-in -69.19, -57.7 73.02, -1.06 out-out-out SNCooo out-out ActLoopNT-out 8.325 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -150.75, 155.46 APE9-dihe-na -104.35, -179.3 APE8-dihe-out -103.86, -21.71 APE8-rot-out 60.0 APE67-dihe-out -161.36, 138.21 -120.01, -175.99 APE12-dist-out 17.629 APE11-dist-out 18.098 APE10-dist-out 21.191 APE9-dist-out 12.184 S218A,S222A None None XRAY 2.59 0.222 0.245 B 397 314 32 0 0 0 [[68, 361]] 1.0 6pp9 STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0VB Q02750 42 383 393.0 ANP:801,EUI:803 ATPlike,Type3 Inactive DFGin 6.038 13.738 BLBplus -152.98, 176.74 51.89, 40.05 -97.58, 155.01 48.54, 94.68 -74.32, 76.65 out-out out 15.356 Saltbr-out 15.248 HRD-in -53.62, -41.23 79.48, -8.01 out-out-out SNCooo out-out ActLoopNT-out 8.451 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -59.78, 136.18 APE9-dihe-na -90.07, -164.06 APE8-dihe-out -111.55, -13.91 APE8-rot-out 80.18 APE67-dihe-out -157.27, 123.12 -113.49, 175.2 APE12-dist-out 17.753 APE11-dist-out 19.587 APE10-dist-out 21.216 APE9-dist-out 13.438 S218A,S222A None None XRAY 3.16 0.188 0.234 B 397 310 32 0 0 0 [[68, 361]] 1.0 7m0v STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0WB Q02750 42 383 393.0 ANP:801,QOA:803 ATPlike,Type3 Inactive DFGin 6.148 14.055 BLBplus -157.1, -177.15 57.47, 39.21 -94.37, 139.97 49.64, 89.26 -60.24, 75.28 out-out out 15.239 Saltbr-out 15.181 HRD-in -60.24, -53.72 67.58, 4.61 out-out-out SNCooo out-out ActLoopNT-out 8.866 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -57.72, 142.94 APE9-dihe-na -85.2, -169.93 APE8-dihe-out -102.45, -22.28 APE8-rot-out 37.77 APE67-dihe-out -129.82, 144.3 -151.67, 158.88 APE12-dist-out 17.512 APE11-dist-out 22.657 APE10-dist-out 23.477 APE9-dist-out 13.59 S218A,S222A None None XRAY 3.09 0.197 0.233 B 397 310 32 0 0 0 [[68, 361]] 1.0 7m0w STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0XB Q02750 40 383 393.0 ANP:801,4BM:803 ATPlike,Type3 Inactive DFGin 6.04 13.707 BLBplus -145.13, 173.52 62.48, 32.29 -85.3, 166.26 43.84, 89.91 -82.62, 63.8 out-out out 15.219 Saltbr-out 15.128 HRD-in -57.93, -57.46 71.94, -0.74 out-out-out SNCooo out-out ActLoopNT-out 8.331 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -140.02, 147.44 APE9-dihe-na -87.47, -179.23 APE8-dihe-out -111.82, -15.11 APE8-rot-out 56.07 APE67-dihe-out -151.04, 140.91 -141.23, 175.81 APE12-dist-out 17.795 APE11-dist-out 17.919 APE10-dist-out 21.393 APE9-dist-out 11.986 S218A,S222A None None XRAY 2.47 0.18 0.215 B 397 312 32 0 0 0 [[68, 361]] 1.0 7m0x STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0YB Q02750 43 382 393.0 ANP:401,QOM:404 ATPlike,Type3 Inactive DFGin 5.931 13.967 BLBplus -158.94, 162.56 56.25, 36.06 -89.69, 147.0 54.27, 82.92 -67.13, 108.1 out-out out 15.493 Saltbr-out 15.962 HRD-in -58.74, -61.39 74.04, 6.51 out-out-out SNCooo out-out ActLoopNT-out 9.402 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -63.76, 140.76 APE9-dihe-na -82.11, -165.89 APE8-dihe-out -109.48, -23.44 APE8-rot-out 48.75 APE67-dihe-out -133.69, 134.38 -151.5, 158.4 APE12-dist-out 17.381 APE11-dist-out 22.453 APE10-dist-out 23.379 APE9-dist-out 13.66 S218A,S222A None None XRAY 3.45 0.196 0.218 B 397 308 32 0 0 0 [[68, 361]] 1.0 7m0y STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0ZB Q02750 42 383 393.0 ANP:401,CHU:402 ATPlike,Type3 Inactive DFGin 6.106 14.107 BLBplus -160.77, 175.85 59.87, 41.63 -97.41, 152.84 45.88, 80.73 -66.99, 92.55 out-out out 15.493 Saltbr-out 15.371 HRD-in -96.91, -40.79 69.65, -8.88 out-out-out SNCooo out-out ActLoopNT-out 9.612 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -66.4, 138.99 APE9-dihe-na -84.75, -165.15 APE8-dihe-out -106.74, -38.37 APE8-rot-out 38.19 APE67-dihe-out -129.38, 138.55 -136.73, 157.33 APE12-dist-out 17.213 APE11-dist-out 22.382 APE10-dist-out 23.613 APE9-dist-out 13.603 S218A,S222A None None XRAY 3.12 0.193 0.225 B 397 310 32 0 0 0 [[68, 361]] 1.0 7m0z STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXHA Q02750 39 381 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.113 14.205 BLBplus -138.52, 176.84 56.32, 45.26 -98.43, 166.79 48.45, 76.71 -79.29, 73.17 out-out out 15.389 Saltbr-out 15.461 HRD-in -79.27, -55.22 75.38, 2.3 out-out-out SNCooo out-out ActLoopNT-out 9.391 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -141.27, 126.74 APE9-dihe-na -91.23, -150.48 APE8-dihe-out -108.84, -16.83 APE8-rot-out 178.7 APE67-dihe-out -130.79, 128.8 -115.86, 151.78 APE12-dist-out 17.417 APE11-dist-out 17.624 APE10-dist-out 20.898 APE9-dist-out 13.154 None None None XRAY 2.81 0.206 0.253 A 310 299 0 0 0 0 [[68, 361]] 1.0 9axh STE_MAP2K1_HUMAN STE 1.5e-98 335.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXHB Q02750 38 381 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.028 13.959 BLBplus -143.4, 172.79 59.61, 49.11 -104.03, 163.1 47.48, 79.51 -74.37, 70.81 out-out out 15.415 Saltbr-out 14.817 HRD-in -76.49, -58.47 81.39, -4.23 out-out-out SNCooo out-out ActLoopNT-out 9.322 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -140.95, 129.53 APE9-dihe-na -95.7, -172.17 APE8-dihe-out -83.87, -23.26 APE8-rot-out 67.32 APE67-dihe-out -134.03, 129.22 -119.03, 156.34 APE12-dist-out 17.307 APE11-dist-out 17.575 APE10-dist-out 20.9 APE9-dist-out 12.718 None None None XRAY 2.81 0.206 0.253 B 310 300 0 0 0 0 [[68, 361]] 1.0 9axh STE_MAP2K1_HUMAN STE 1.5e-98 335.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXMA Q02750 38 382 393.0 A1AHE:60401,ANP:60403 Type1,ATPlike Inactive DFGin 6.204 13.999 BLBplus -146.84, 170.95 57.84, 58.3 -113.46, 158.4 47.1, 81.42 -71.93, 78.64 out-out out 15.426 Saltbr-out 15.513 HRD-in -80.25, -54.29 71.05, 3.5 out-out-out SNCooo out-out ActLoopNT-out 9.11 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -58.81, 135.38 APE9-dihe-na -86.44, -174.93 APE8-dihe-out -114.7, -19.48 APE8-rot-out 61.33 APE67-dihe-out -156.42, 133.96 -137.25, 175.14 APE12-dist-out 17.347 APE11-dist-out 22.123 APE10-dist-out 24.223 APE9-dist-out 13.241 S218A,S222A None None XRAY 2.42 0.263 0.301 A 310 301 0 0 0 0 [[68, 361]] 1.0 9axm STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXXA Q02750 41 382 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.157 14.473 BLBplus -142.21, 167.57 61.94, 40.19 -92.82, 170.58 38.95, 89.02 -82.21, 74.48 out-out out 15.925 Saltbr-out 15.661 HRD-in -77.34, -56.94 85.02, -11.71 out-out-out SNCooo out-out ActLoopNT-out 9.623 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -70.01, 140.02 APE9-dihe-na -107.63, 178.58 APE8-dihe-out -103.64, -13.88 APE8-rot-out 56.98 APE67-dihe-out -152.18, 145.48 -132.34, 175.09 APE12-dist-out 18.633 APE11-dist-out 16.086 APE10-dist-out 21.091 APE9-dist-out 12.771 S218A,S222A None None XRAY 2.07 0.215 0.248 A 310 298 0 0 0 0 [[68, 361]] 1.0 9axx STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXXC Q02750 37 378 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.066 14.251 BLBplus -153.34, 165.37 62.85, 41.08 -93.54, 164.6 44.67, 86.41 -75.31, 71.49 out-out out 15.517 Saltbr-out 15.022 HRD-in -80.68, -38.87 53.15, 7.3 out-out-out SNCooo out-out ActLoopNT-out 9.691 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -68.91, 127.09 APE9-dihe-na -100.27, 169.31 APE8-dihe-out -98.12, -23.61 APE8-rot-out 61.42 APE67-dihe-out -153.77, 146.66 -125.41, 178.29 APE12-dist-out 18.45 APE11-dist-out 16.119 APE10-dist-out 21.581 APE9-dist-out 12.749 S218A,S222A None None XRAY 2.07 0.215 0.248 C 310 297 1 0 0 0 [[68, 361]] 1.0 9axx STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AYAB Q02750 42 382 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.209 14.117 BLBplus -156.4, 169.03 57.59, 47.08 -100.39, 159.82 46.95, 83.0 -73.48, 80.99 out-out out 15.444 Saltbr-out 14.957 HRD-in -72.22, -50.64 78.5, -7.92 out-out-out SNCooo out-out ActLoopNT-out 9.725 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -67.32, 133.53 APE9-dihe-na -94.07, -169.54 APE8-dihe-out -110.54, -56.8 APE8-rot-out 71.18 APE67-dihe-out -155.6, 139.89 -98.61, 175.74 APE12-dist-out 17.221 APE11-dist-out 22.149 APE10-dist-out 24.195 APE9-dist-out 13.766 S218A,S222A None None XRAY 2.59 0.214 0.257 B 310 297 0 0 0 0 [[68, 361]] 1.0 9aya STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AYAD Q02750 39 382 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.236 14.114 BLBplus -150.42, 169.48 62.14, 35.37 -84.74, 166.85 39.42, 88.37 -83.08, 73.44 out-out out 15.382 Saltbr-out 15.287 HRD-in -84.82, -56.5 86.5, -11.08 out-out-out SNCooo out-out ActLoopNT-out 9.653 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 132.69 APE8-dihe-out -103.38, -24.48 APE8-rot-out 47.89 APE67-dihe-out -161.23, 135.82 -100.94, -174.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.749 S218A,S222A None None XRAY 2.59 0.214 0.257 D 310 293 7 0 0 3 [[68, 361]] 1.0 9aya STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AY7B Q02750 33 383 393.0 A1AHE:401,ANP:402 Type1,ATPlike Inactive DFGin 6.131 14.268 BLBplus -154.96, 169.08 61.0, 36.72 -91.6, 162.02 49.73, 81.71 -77.61, 77.19 out-out out 15.513 Saltbr-out 15.402 HRD-in -75.89, -55.94 83.29, -11.88 out-out-out SNCooo out-out ActLoopNT-out 9.576 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -66.62, 136.57 APE9-dihe-na -89.93, -175.43 APE8-dihe-out -113.57, -10.62 APE8-rot-out 51.26 APE67-dihe-out -146.5, 144.85 -157.42, 170.13 APE12-dist-out 17.344 APE11-dist-out 22.114 APE10-dist-out 24.207 APE9-dist-out 13.729 S218A,S222A None None XRAY 2.41 0.203 0.236 B 394 322 29 0 0 0 [[68, 361]] 1.0 9ay7 STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0UH Q02750 30 380 393.0 CHU:401,ANP:402 Type1,ATPlike Inactive DFGin 6.226 14.24 BLBplus -153.68, 170.44 61.41, 47.24 -102.95, 164.39 45.69, 94.01 -79.55, 83.41 out-out out 15.581 Saltbr-out 15.785 HRD-in -74.86, -48.68 73.9, -6.25 out-out-out SNCooo out-out ActLoopNT-out 9.583 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -141.84, 152.52 APE9-dihe-na -130.16, 177.33 APE8-dihe-out -105.34, -25.09 APE8-rot-out 37.73 APE67-dihe-out -147.39, 136.35 -136.55, 176.51 APE12-dist-out 17.387 APE11-dist-out 17.659 APE10-dist-out 22.215 APE9-dist-out 12.997 S218A,S222A None None XRAY 2.91 0.232 0.264 H 395 315 36 0 0 0 [[68, 361]] 1.0 9o0u STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0VB Q02750 30 380 393.0 CHU:401,ANP:402 Type1,ATPlike Inactive DFGin 6.193 14.125 BLBplus -151.85, 167.5 59.4, 48.24 -102.03, 163.4 46.52, 86.88 -79.89, 84.21 out-out out 15.595 Saltbr-out 16.841 HRD-in -72.2, -48.2 74.46, -6.51 out-out-out SNCooo out-out ActLoopNT-out 9.706 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -135.59, 156.7 APE9-dihe-na -122.67, 146.4 APE8-dihe-out -101.77, -26.6 APE8-rot-in 280.72 APE67-dihe-out -147.98, 135.29 -136.69, 175.09 APE12-dist-out 16.923 APE11-dist-out 17.129 APE10-dist-out 21.862 APE9-dist-out 12.429 S218A,S222A None None XRAY 3.5 0.208 0.254 B 395 322 29 0 0 0 [[68, 361]] 1.0 9o0v STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0VH Q02750 30 380 393.0 CHU:401,ANP:402 Type1,ATPlike Inactive DFGin 6.349 14.227 BLBplus -152.81, 169.25 61.22, 47.15 -103.13, 164.19 45.91, 94.17 -79.63, 83.31 out-out out 15.632 Saltbr-out 15.916 HRD-in -74.73, -48.72 73.54, -6.07 out-out-out SNCooo out-out ActLoopNT-out 9.507 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -142.21, 151.98 APE9-dihe-na -130.61, 176.34 APE8-dihe-out -105.52, -25.24 APE8-rot-out 37.89 APE67-dihe-out -147.93, 136.16 -136.73, 176.12 APE12-dist-out 17.277 APE11-dist-out 17.584 APE10-dist-out 22.152 APE9-dist-out 13.001 S218A,S222A None None XRAY 3.5 0.208 0.254 H 395 318 33 0 0 0 [[68, 361]] 1.0 9o0v STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4U7ZA Q02750 62 382 393.0 3EW:60502,ANP:60503 Type3,ATPlike Inactive DFGin 6.216 13.669 BLBplus -143.34, -175.79 52.44, 38.8 -93.27, 161.31 44.21, 87.69 -81.82, 73.69 out-out out 15.334 Saltbr-out 16.14 HRD-in -66.47, -61.07 88.23, -17.21 out-out-out SNCooo out-out ActLoopNT-out 9.199 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_onoo APE10-dihe-na 999.0, -56.79 APE9-dihe-na 112.87, -133.38 APE8-dihe-out -132.3, 18.52 APE8-rot-out 53.52 APE67-dihe-out -108.34, 133.35 -145.71, 114.06 APE12-dist-out 17.933 APE11-dist-none 999.0 APE10-dist-out 19.601 APE9-dist-out 13.953 None None None XRAY 2.805 0.163 0.214 A 341 290 31 0 0 1 [[68, 361]] 1.0 4u7z STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4U81A Q02750 62 382 393.0 3EY:60502,ANP:60503 Type3,ATPlike Inactive DFGin 6.368 13.575 BLBplus -142.15, -179.17 57.69, 35.98 -93.9, 164.88 44.15, 86.95 -87.34, 72.9 out-out out 15.275 Saltbr-out 15.416 HRD-in -63.27, -55.06 80.23, -11.72 out-out-out SNCooo out-out ActLoopNT-out 9.324 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -28.47 APE9-dihe-na 110.81, -177.13 APE8-dihe-out -114.66, 19.88 APE8-rot-out 189.5 APE67-dihe-out -109.38, 142.31 -159.49, 131.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.684 APE9-dist-out 12.969 None None None XRAY 2.701 0.169 0.218 A 341 288 33 0 0 3 [[68, 361]] 1.0 4u81 STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9ECUB Q02750 43 383 393.0 A1BIS:401,ANP:402 Type3,ATPlike Inactive DFGin 5.939 13.778 BLBplus -142.06, 162.17 53.85, 47.21 -95.43, 152.31 51.94, 84.92 -79.97, 96.68 out-out out 15.512 Saltbr-out 16.13 HRD-in -66.75, -57.05 86.44, -9.92 out-out-out SNCooo out-out ActLoopNT-out 9.377 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -121.25, 157.88 APE9-dihe-na -135.0, 168.26 APE8-dihe-out -68.75, -42.35 APE8-rot-in 291.8 APE67-dihe-out -146.65, 140.6 -150.67, 174.43 APE12-dist-out 21.121 APE11-dist-out 17.894 APE10-dist-out 23.135 APE9-dist-out 13.656 None None None XRAY 3.46 0.202 0.237 B 393 309 32 0 0 0 [[68, 361]] 1.0 9ecu STE_MAP2K1_HUMAN STE 2.4e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXYB Q02750 40 383 393.0 A1AHE:401,ANP:402 Type3,ATPlike Inactive DFGin 5.938 14.134 BLBplus -149.11, 165.49 51.9, 40.29 -92.3, 159.5 54.58, 76.32 -75.9, 70.87 out-out out 15.399 Saltbr-out 14.988 HRD-in -57.0, -47.47 79.88, -10.87 out-out-out SNCooo out-out ActLoopNT-out 9.337 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -115.09, 128.49 APE9-dihe-na -79.18, 173.05 APE8-dihe-out -111.11, -19.81 APE8-rot-out 47.95 APE67-dihe-out -148.5, 141.81 -130.51, 175.5 APE12-dist-out 18.176 APE11-dist-out 19.731 APE10-dist-out 22.785 APE9-dist-out 13.229 S218A,S222A None None XRAY 3.6 0.19 0.237 B 394 312 32 0 0 0 [[68, 361]] 1.0 9axy STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0VD Q02750 31 380 393.0 CHU:401,ANP:402 Type3,ATPlike Inactive DFGin 6.373 14.325 BLBplus -154.54, 169.16 62.18, 48.49 -103.44, 163.24 44.6, 81.5 -80.27, 83.26 out-out out 16.084 Saltbr-out 14.605 HRD-in -72.92, -47.49 72.01, -5.54 out-out-out SNCooo out-out ActLoopNT-out 9.498 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -145.24, 151.58 APE9-dihe-na -129.14, 150.7 APE8-dihe-out -101.27, -25.48 APE8-rot-in 295.39 APE67-dihe-out -149.5, 133.8 -134.87, 174.51 APE12-dist-out 17.681 APE11-dist-out 17.587 APE10-dist-out 22.613 APE9-dist-out 12.734 S218A,S222A None None XRAY 3.5 0.208 0.254 D 395 315 35 0 0 0 [[68, 361]] 1.0 9o0v STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0VF Q02750 30 380 393.0 CHU:401,ANP:402 Type3,ATPlike Inactive DFGin 6.348 14.297 BLBplus -150.02, 162.92 66.4, 48.22 -102.89, 163.79 46.62, 89.05 -79.32, 84.9 out-out out 15.51 Saltbr-out 15.882 HRD-in -75.24, -46.98 72.8, -6.4 out-out-out SNCooo out-out ActLoopNT-out 9.801 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -127.4, 126.99 APE9-dihe-na -155.92, 117.08 APE8-dihe-out -98.23, -9.95 APE8-rot-in 320.72 APE67-dihe-out -148.49, 134.6 -133.67, 172.28 APE12-dist-out 18.674 APE11-dist-out 16.74 APE10-dist-out 21.344 APE9-dist-out 12.703 S218A,S222A None None XRAY 3.5 0.208 0.254 F 395 322 29 0 0 0 [[68, 361]] 1.0 9o0v STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0TB Q02750 42 383 393.0 3EW:401,ANP:402 Type3,ATPlike Inactive DFGin 6.075 13.71 BLBplus -159.9, -178.5 64.02, 41.63 -104.3, 143.17 46.34, 100.82 -64.54, 70.24 out-out out 15.478 Saltbr-out 16.332 HRD-in -53.73, -55.69 69.68, 5.22 out-out-out SNCooo out-out ActLoopNT-out 8.871 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -40.91, 141.26 APE9-dihe-na -101.18, -177.28 APE8-dihe-out -68.44, -50.32 APE8-rot-in 321.79 APE67-dihe-out -148.38, 132.66 -145.97, 175.15 APE12-dist-out 17.166 APE11-dist-out 22.648 APE10-dist-out 23.709 APE9-dist-out 13.864 S218A,S222A None None XRAY 3.19 0.199 0.254 B 397 310 32 0 0 0 [[68, 361]] 1.0 7m0t STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0UB Q02750 43 385 393.0 QO7:501,ANP:502 Type3,ATPlike Inactive DFGin 6.178 13.84 BLBplus -152.87, -177.82 54.02, 43.66 -96.33, 148.45 42.9, 86.91 -71.94, 82.66 out-out out 15.493 Saltbr-out 15.664 HRD-in -60.41, -57.85 71.46, -3.21 out-out-out SNCooo out-out ActLoopNT-out 9.048 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -60.78, 138.09 APE9-dihe-na -86.76, -175.69 APE8-dihe-out -100.26, -15.57 APE8-rot-out 49.06 APE67-dihe-out -118.78, 147.11 -163.65, 150.46 APE12-dist-out 17.201 APE11-dist-out 22.359 APE10-dist-out 23.566 APE9-dist-out 13.638 S218A,S222A None None XRAY 3.09 0.193 0.23 B 397 311 32 0 0 0 [[68, 361]] 1.0 7m0u STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 5YT3B Q02750 40 382 393.0 ANP:401 ATPlike Inactive DFGin 5.896 14.534 None -102.15, -169.78 -40.15, 149.52 -75.91, 143.56 303.08, 84.8 -64.88, 94.03 out-out out 16.359 Saltbr-out 14.866 HRD-out -104.42, 23.77 -144.46, 111.13 out-out-out SNCooo out-out ActLoopNT-out 8.021 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -80.58, -32.09 APE9-dihe-na -86.11, -15.83 APE8-dihe-out 58.15, 64.44 APE8-rot-in 310.76 APE67-dihe-out -122.56, 143.11 -138.66, 139.98 APE12-dist-out 19.055 APE11-dist-out 14.055 APE10-dist-out 18.84 APE9-dist-out 25.91 S218D,S222D,T292A,S298A None None XRAY 2.9 0.213 0.289 B 350 311 32 0 0 0 [[68, 361]] 1.0 5yt3 STE_MAP2K1_HUMAN STE 4.7e-97 330.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 5YT3D Q02750 39 382 393.0 ANP:401 ATPlike Inactive DFGin 5.75 14.718 None -77.53, 172.31 -71.81, 159.92 -66.82, 141.72 314.31, 87.77 -59.96, 135.61 out-out out 16.872 Saltbr-out 15.006 HRD-out -106.97, -11.01 -97.02, 107.72 out-out-out SNCooo out-out ActLoopNT-out 8.244 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -63.82, -51.0 APE9-dihe-na -70.37, -13.35 APE8-dihe-out 47.35, 74.88 APE8-rot-out 143.99 APE67-dihe-out -134.73, 126.26 -143.64, 140.67 APE12-dist-out 19.339 APE11-dist-out 14.382 APE10-dist-out 19.155 APE9-dist-out 26.168 S218D,S222D,T292A,S298A None None XRAY 2.9 0.213 0.289 D 350 309 35 0 0 0 [[68, 361]] 1.0 5yt3 STE_MAP2K1_HUMAN STE 4.7e-97 330.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 5YT3A Q02750 39 382 393.0 ANP:401 ATPlike Inactive DFGinter 6.357 10.383 None -128.68, 173.26 63.68, 38.66 -52.93, -21.76 28.6, 36.22 -61.84, 114.84 out-out out 16.315 Saltbr-out 14.589 HRD-in -77.7, -42.23 58.41, 13.61 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 70.97 APE8-rot-none 999.0 APE67-dihe-out -132.4, 139.8 -149.07, 91.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S218D,S222D,T292A,S298A None None XRAY 2.9 0.213 0.289 A 350 297 47 0 0 14 [[68, 361]] 1.0 5yt3 STE_MAP2K1_HUMAN STE 4.7e-97 330.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7F2XA Q02750 45 382 393.0 ANP:60501 ATPlike Inactive None 14.578 16.496 None -71.03, 160.3 -74.32, 105.83 -69.14, -7.13 285.96, 1.01 -79.69, -8.9 out-out out 16.361 Saltbr-out 16.873 HRD-out -123.25, -2.01 -136.26, 151.99 out-out-out SNCooo out-out ActLoopNT-out 10.375 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -84.56, -47.24 APE9-dihe-na 151.04, 109.57 APE8-dihe-in -68.48, 129.23 APE8-rot-in 304.12 APE67-dihe-out -103.66, 129.16 -127.47, 104.31 APE12-dist-out 14.456 APE11-dist-out 17.673 APE10-dist-out 20.308 APE9-dist-out 25.523 None None None XRAY 2.007 0.216 0.232 A 321 300 0 0 0 0 [[68, 361]] 1.0 7f2x STE_MAP2K1_HUMAN STE 1.4e-97 332.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K4 MP2K4_HUMAN 3ALNA P45985 83 389 399.0 ANP:1 ATPlike Inactive DFGin 6.517 13.393 BLBplus -161.78, 169.91 72.82, 15.08 -92.63, 122.04 60.81, 71.89 121.07, -111.8 na-na na 15.525 Saltbr-na 999.0 HRD-in -50.15, -58.45 86.79, 0.09 na-out-none SNCaon out-none ActLoopNT-out 11.094 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.289 0.378 A 327 270 37 0 0 20 [[102, 367]] 1.0 3aln STE_MAP2K4_HUMAN STE 6.8e-86 293.8 4 257 254 246 247 248 250 252 131 148 152 226 228 227 229 289 273 268 267 266 265 264 263 262 179 Dual specificity mitogen-activated protein kinase kinase 4
STE MAP2K4 MP2K4_HUMAN 3ALNB P45985 84 390 399.0 ANP:1 ATPlike Inactive DFGin 7.062 13.613 BLBplus -140.58, 160.03 87.63, 22.27 -95.55, 159.55 58.77, 88.3 94.56, -147.05 na-na na 15.267 Saltbr-na 14.949 HRD-in -87.89, -53.1 65.57, 1.61 na-out-none SNCaon out-none ActLoopNT-out 8.255 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.289 0.378 B 327 263 44 0 0 19 [[102, 367]] 1.0 3aln STE_MAP2K4_HUMAN STE 6.8e-86 293.8 4 257 254 246 247 248 250 252 131 148 152 226 228 227 229 289 273 268 267 266 265 264 263 262 179 Dual specificity mitogen-activated protein kinase kinase 4
STE MAP2K4 MP2K4_HUMAN 3ALOA P45985 95 389 399.0 ANP:406 ATPlike Inactive DFGin 6.887 13.729 BLBplus -112.59, -177.7 66.85, 21.6 -92.73, 167.28 50.76, 92.54 73.18, -126.21 na-na na 15.89 Saltbr-na 16.476 HRD-in -52.75, -64.74 82.96, 2.2 na-out-out SNCaoo out-out ActLoopNT-out 8.257 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na -57.34, 98.51 APE9-dihe-na 135.89, -16.86 APE8-dihe-out -126.39, -33.94 APE8-rot-na 70.02 APE67-dihe-out -48.7, -17.03 -94.49, 137.34 APE12-dist-out 18.454 APE11-dist-out 19.517 APE10-dist-out 20.495 APE9-dist-out 23.026 None None None XRAY 2.6 0.209 0.271 A 327 289 6 0 0 0 [[102, 367]] 1.0 3alo STE_MAP2K4_HUMAN STE 6.8e-86 293.8 4 257 254 246 247 248 250 252 131 148 152 226 228 227 229 289 273 268 267 266 265 264 263 262 179 Dual specificity mitogen-activated protein kinase kinase 4
STE MAP2K4 MP2K4_HUMAN 3ALNC P45985 100 390 399.0 ANP:1 ATPlike Inactive None 999.0 11.66 None -139.2, 85.12 54.71, 167.37 -67.61, 999.0 74.38, 108.84 999.0, 999.0 na-na na 999.0 Saltbr-na 999.0 HRD-none 999.0, 999.0 999.0, 999.0 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.289 0.378 C 327 183 108 0 0 25 [[102, 367]] 1.0 3aln STE_MAP2K4_HUMAN STE 6.8e-86 293.8 4 257 254 246 247 248 250 252 131 148 152 226 228 227 229 289 273 268 267 266 265 264 263 262 179 Dual specificity mitogen-activated protein kinase kinase 4
STE MAP4K1 M4K1_HUMAN 6CQDA Q92918 2 293 833.0 ANP:60301 ATPlike Inactive DFGin 6.032 13.886 BLAminus -140.97, 178.85 65.6, 83.06 -106.07, 25.72 286.0, 93.85 -58.74, -52.87 in-in in 8.588 Saltbr-in 2.603 HRD-in -75.86, -49.25 70.86, -6.64 in-out-out SNCioo out-out ActLoopNT-out 5.612 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -107.43, -47.34 APE9-dihe-na -128.13, -155.64 APE8-dihe-in -106.29, 135.18 APE8-rot-out 173.28 APE67-dihe-in -57.05, -28.95 -70.03, -34.9 APE12-dist-out 19.71 APE11-dist-out 23.507 APE10-dist-out 22.083 APE9-dist-out 27.312 None None None XRAY 2.12 0.206 0.25 A 297 288 4 0 0 0 [[17, 274]] 1.0 6cqd STE_MAP4K1_HUMAN STE 4.2e-92 314.0 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6CQDB Q92918 4 293 833.0 ANP:60302 ATPlike Inactive DFGin 6.101 14.229 BLAminus -144.26, -175.8 58.68, 77.54 -93.97, 33.74 292.79, 90.96 -66.13, -50.88 in-in in 9.463 Saltbr-in 3.209 HRD-in -76.3, -46.87 66.26, 5.48 in-out-out SNCioo out-out ActLoopNT-out 6.073 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -81.26, 126.5 APE9-dihe-na -81.79, -144.73 APE8-dihe-in -66.65, 145.16 APE8-rot-out 188.81 APE67-dihe-in -66.31, -22.65 -105.18, -2.62 APE12-dist-out 20.763 APE11-dist-out 21.959 APE10-dist-out 21.41 APE9-dist-out 27.357 None None None XRAY 2.12 0.206 0.25 B 297 290 0 0 0 0 [[17, 274]] 1.0 6cqd STE_MAP4K1_HUMAN STE 4.2e-92 314.0 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K4 M4K4_HUMAN 4U40A O95819 17 311 1239.0 ANP:401 ATPlike Inactive DFGin 3.837 14.39 BLBplus -136.79, 156.81 66.63, 45.06 -75.84, 145.72 56.03, 93.39 -61.09, 117.37 out-out out 11.64 Saltbr-out 10.489 HRD-in -68.35, -49.63 65.89, 2.04 out-out-out SNCooo out-out ActLoopNT-out 9.628 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -76.11, -36.45 APE9-dihe-na 89.46, 175.41 APE8-dihe-in -63.67, 133.35 APE8-rot-out 188.73 APE67-dihe-in -61.71, -22.93 -96.09, -7.57 APE12-dist-out 14.877 APE11-dist-out 14.965 APE10-dist-out 15.978 APE9-dist-out 9.477 None None None XRAY 2.3 0.201 0.262 A 332 295 0 0 0 0 [[25, 289]] 1.0 4u40 STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
STE OXSR1 OXSR1_HUMAN 3DAKA O95747 6 295 527.0 ANP:1 ATPlike Inactive DFGin 5.129 16.177 BLBtrans -100.04, 163.42 76.18, 16.7 -60.44, 136.33 171.32, 70.03 96.86, -127.31 out-out out 12.585 Saltbr-out 12.035 HRD-in -76.04, -45.57 81.12, -26.2 out-out-out SNCooo out-out ActLoopNT-out 8.169 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -91.06 APE9-dihe-na 161.92, -137.1 APE8-dihe-in -95.05, 112.91 APE8-rot-in 254.7 APE67-dihe-in -56.68, -24.99 -85.34, 38.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 29.384 APE9-dist-out 30.051 None None None XRAY 2.25 0.199 0.267 A 290 279 11 0 0 11 [[17, 291]] 1.0 3dak STE_OXSR1_HUMAN STE 6e-94 320.1 1 257 257 163 164 165 167 169 46 63 67 143 145 144 146 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 3DAKB O95747 6 295 527.0 ANP:1 ATPlike Inactive DFGin 5.332 16.237 BLBtrans -104.22, 159.58 79.05, 11.08 -51.8, 136.57 175.99, 64.12 96.31, -131.54 out-out out 12.456 Saltbr-out 12.083 HRD-in -78.09, -47.02 83.9, -24.13 out-out-none SNCoon out-none ActLoopNT-out 8.147 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 130.99 APE8-rot-in 294.38 APE67-dihe-in -53.25, -31.09 -85.79, 34.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.25 0.199 0.267 B 290 278 12 0 0 12 [[17, 291]] 1.0 3dak STE_OXSR1_HUMAN STE 6e-94 320.1 1 257 257 163 164 165 167 169 46 63 67 143 145 144 146 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 3DAKC O95747 7 295 527.0 ANP:1 ATPlike Inactive DFGin 5.2 16.258 BLBtrans -99.19, 165.37 77.39, 13.36 -54.55, 139.89 174.92, 66.03 90.2, -129.87 out-out out 12.795 Saltbr-out 12.192 HRD-in -79.55, -55.89 92.02, -15.23 out-out-out SNCooo out-out ActLoopNT-out 8.072 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -81.49, 148.28 APE9-dihe-na 113.95, 160.67 APE8-dihe-in -84.39, 122.06 APE8-rot-out 195.33 APE67-dihe-in -62.35, -26.54 -78.99, 38.41 APE12-dist-out 26.325 APE11-dist-out 28.851 APE10-dist-out 33.354 APE9-dist-out 31.678 None None None XRAY 2.25 0.199 0.267 C 290 281 8 0 0 8 [[17, 291]] 1.0 3dak STE_OXSR1_HUMAN STE 6e-94 320.1 1 257 257 163 164 165 167 169 46 63 67 143 145 144 146 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 3DAKD O95747 7 295 527.0 ANP:1 ATPlike Inactive DFGin 5.521 16.6 BLBtrans -91.03, 168.13 66.29, 18.87 -59.74, 133.08 178.71, 62.0 94.13, -120.8 out-out out 12.738 Saltbr-out 12.031 HRD-in -82.87, -52.16 83.38, -16.35 out-out-out SNCooo out-out ActLoopNT-out 8.249 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -78.42, 169.6 APE9-dihe-na 94.12, 158.49 APE8-dihe-in -86.45, 138.34 APE8-rot-out 182.04 APE67-dihe-in -59.03, -28.5 -85.94, 35.36 APE12-dist-none 999.0 APE11-dist-out 29.808 APE10-dist-out 33.489 APE9-dist-out 31.915 None None None XRAY 2.25 0.199 0.267 D 290 284 5 0 0 5 [[17, 291]] 1.0 3dak STE_OXSR1_HUMAN STE 6e-94 320.1 1 257 257 163 164 165 167 169 46 63 67 143 145 144 146 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 2VWIB O95747 9 292 527.0 ANP:1295 ATPlike Inactive DFGin 5.287 16.427 BLBtrans -100.18, 160.58 80.18, 12.17 -59.65, 137.68 171.88, 72.09 96.85, -127.69 out-out out 12.997 Saltbr-out 12.206 HRD-in -71.44, -47.93 86.11, -20.42 out-out-none SNCoon out-none ActLoopNT-out 7.967 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 75.95 APE8-rot-in 320.74 APE67-dihe-in -62.37, -32.44 -100.52, 20.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.15 0.253 0.287 B 303 264 20 0 0 12 [[17, 291]] 1.0 2vwi STE_OXSR1_HUMAN STE 7.1e-94 319.8 1 257 257 163 164 165 167 169 46 63 67 143 145 144 146 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 2VWIC O95747 9 292 527.0 ANP:1294 ATPlike Inactive DFGin 5.301 16.228 BLBtrans -96.83, 164.86 72.67, 17.81 -61.87, 137.0 171.22, 69.43 96.65, -124.96 out-out out 12.818 Saltbr-out 12.435 HRD-in -77.27, -48.25 84.09, -19.76 out-out-out SNCooo out-out ActLoopNT-out 7.978 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 143.21 APE9-dihe-na 99.05, -143.58 APE8-dihe-in -115.19, 90.11 APE8-rot-out 49.11 APE67-dihe-in -67.35, -20.96 -80.96, 15.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 29.087 APE9-dist-out 29.408 None None None XRAY 2.15 0.253 0.287 C 303 271 13 0 0 5 [[17, 291]] 1.0 2vwi STE_OXSR1_HUMAN STE 7.1e-94 319.8 1 257 257 163 164 165 167 169 46 63 67 143 145 144 146 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 2VWID O95747 6 298 527.0 ANP:1300 ATPlike Inactive DFGin 5.179 16.223 BLBtrans -101.51, 161.03 73.3, 16.0 -58.73, 139.72 167.14, 71.27 94.08, -129.9 out-out out 12.663 Saltbr-out 12.411 HRD-in -67.92, -49.61 77.45, -14.4 out-out-out SNCooo out-out ActLoopNT-out 7.943 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -84.67, 122.36 APE9-dihe-na 118.58, -169.41 APE8-dihe-in -120.4, 114.0 APE8-rot-in 321.26 APE67-dihe-in -59.9, -22.77 -41.25, -46.54 APE12-dist-out 29.134 APE11-dist-out 28.073 APE10-dist-out 29.314 APE9-dist-out 29.161 None None None XRAY 2.15 0.253 0.287 D 303 284 9 0 0 9 [[17, 291]] 1.0 2vwi STE_OXSR1_HUMAN STE 7.1e-94 319.8 1 257 257 163 164 165 167 169 46 63 67 143 145 144 146 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 2VWIA O95747 13 292 527.0 ANP:1294 ATPlike Inactive DFGin 8.898 15.601 None -61.18, 158.62 -55.34, 143.64 -131.37, -0.25 74.39, 103.15 -56.05, -46.66 none-none none 999.0 Saltbr-none 999.0 HRD-in -71.19, -49.86 82.28, -11.12 none-out-out SNCnoo out-out ActLoopNT-out 5.998 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -154.6 APE8-dihe-in -114.29, 105.56 APE8-rot-out 57.55 APE67-dihe-in -58.83, -26.11 -92.35, 9.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 28.136 None None None XRAY 2.15 0.253 0.287 A 303 237 43 0 0 15 [[17, 291]] 1.0 2vwi STE_OXSR1_HUMAN STE 7.1e-94 319.8 1 257 257 163 164 165 167 169 46 63 67 143 145 144 146 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE PAK1 PAK1_HUMAN 3Q4ZA Q13153 251 545 545.0 ANP:60800 ATPlike Inactive DFGin 6.086 15.982 BLAminus -129.5, -163.35 61.16, 72.73 -92.37, 13.66 295.77, 79.36 -60.94, -29.11 out-none out 10.187 Saltbr-none 999.0 HRD-in -71.1, -48.5 65.7, -2.93 none-in-in SNCnii in-in ActLoopNT-in 2.767 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.35, 142.5 APE9-dihe-na 131.45, -160.89 APE8-dihe-in -120.18, 125.75 APE8-rot-in 304.74 APE67-dihe-in -64.8, -21.76 -41.32, -52.02 APE12-dist-in 9.957 APE11-dist-in 11.743 APE10-dist-in 6.028 APE9-dist-in 3.332 S259I,K299R,D389N,L516I None None XRAY 1.887 0.186 0.231 A 306 281 12 0 0 0 [[270, 521]] 1.0 3q4z STE_PAK1_HUMAN STE 2e-93 318.4 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK4 PAK4_HUMAN 4FIFA O96013 296 589 591.0 ANP:1000 ATPlike Active DFGin 6.132 13.879 BLAminus -134.27, -172.64 55.78, 65.69 -91.22, 11.11 299.57, 98.92 -61.37, -20.58 in-in in 7.046 Saltbr-in 3.112 HRD-in -73.18, -47.2 74.11, -8.39 in-in-in SNCiii in-in ActLoopNT-in 2.852 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.08, 134.89 APE9-dihe-na 136.18, -173.61 APE8-dihe-in -102.98, 119.55 APE8-rot-in 312.46 APE67-dihe-in -69.75, -26.2 -30.93, -52.34 APE12-dist-in 9.318 APE11-dist-in 11.709 APE10-dist-in 5.875 APE9-dist-in 3.299 None SEP474 SEP474 XRAY 2.6 0.207 0.227 A 346 294 0 0 0 0 [[321, 572]] 1.0 4fif STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIFB O96013 297 589 591.0 ANP:1000 ATPlike Active DFGin 5.899 13.85 BLAminus -129.09, -170.37 52.27, 68.51 -93.51, 10.45 301.97, 96.23 -63.09, -15.01 in-in in 7.007 Saltbr-in 3.167 HRD-in -65.39, -48.9 75.1, -7.5 in-in-in SNCiii in-in ActLoopNT-in 2.801 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.88, 134.77 APE9-dihe-na 136.42, -174.06 APE8-dihe-in -101.96, 121.94 APE8-rot-in 314.36 APE67-dihe-in -72.79, -21.56 -33.03, -50.98 APE12-dist-in 9.238 APE11-dist-in 11.712 APE10-dist-in 5.886 APE9-dist-in 3.335 None SEP474 SEP474 XRAY 2.6 0.207 0.227 B 346 293 0 0 0 0 [[321, 572]] 1.0 4fif STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIGA O96013 298 590 591.0 ANP:1001 ATPlike Inactive DFGin 5.976 13.995 BLAminus -134.45, -166.25 59.06, 57.3 -88.34, 9.13 298.9, 106.14 -61.58, -20.66 in-in in 7.133 Saltbr-in 3.168 HRD-in -77.25, -46.66 72.07, -3.1 in-in-out SNCiio in-out ActLoopNT-in 2.86 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.47, 161.1 APE9-dihe-na 110.61, 163.55 APE8-dihe-in -79.54, 130.34 APE8-rot-out 29.96 APE67-dihe-in -76.38, -28.34 -35.31, -49.63 APE12-dist-in 9.418 APE11-dist-in 11.569 APE10-dist-in 5.635 APE9-dist-in 3.369 None SEP474 SEP474 XRAY 3.01 0.197 0.221 A 346 293 0 0 0 0 [[321, 572]] 1.0 4fig STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4JDIA O96013 300 589 591.0 ANP:1000 ATPlike Active DFGin 6.291 14.47 BLAminus -134.26, 177.87 63.72, 71.58 -94.6, 13.78 289.77, 79.71 -54.15, -28.77 in-in in 6.959 Saltbr-in 2.737 HRD-in -72.82, -49.09 73.48, 2.76 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.62, 145.0 APE9-dihe-na 130.41, -160.49 APE8-dihe-in -120.53, 123.45 APE8-rot-in 305.94 APE67-dihe-in -63.49, -22.51 -36.89, -56.07 APE12-dist-in 8.769 APE11-dist-in 11.535 APE10-dist-in 5.874 APE9-dist-in 3.327 None SEP474 SEP474 XRAY 1.85 0.194 0.233 A 346 290 0 0 0 0 [[321, 572]] 1.0 4jdi STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 5UPKB O96013 300 588 591.0 ANP:60600 ATPlike Active DFGin 6.272 14.139 BLAminus -132.3, -169.35 61.71, 61.5 -87.86, 7.28 293.59, 93.96 -55.36, -28.3 in-in in 7.077 Saltbr-in 3.329 HRD-in -65.35, -49.16 70.36, 11.54 in-in-in SNCiii in-in ActLoopNT-in 2.997 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.55, 149.52 APE9-dihe-na 120.09, -163.11 APE8-dihe-in -119.51, 121.87 APE8-rot-in 313.98 APE67-dihe-in -69.89, -18.98 -32.47, -57.41 APE12-dist-in 8.623 APE11-dist-in 11.267 APE10-dist-in 5.616 APE9-dist-in 3.426 None SEP474 SEP474 XRAY 2.4 0.22 0.264 B 346 289 0 0 0 0 [[321, 572]] 1.0 5upk STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIEA O96013 49 590 591.0 ANP:1001 ATPlike Inactive DFGin 6.278 14.03 BLAminus -142.71, -177.86 63.75, 67.7 -92.97, 13.53 295.29, 98.36 -64.15, -7.0 in-out in 6.991 Saltbr-out 3.974 HRD-in -74.78, -36.69 67.65, -13.13 out-in-out SNCoio in-out ActLoopNT-in 2.856 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -135.98, 139.97 APE9-dihe-na 123.6, -177.34 APE8-dihe-in -84.44, 139.76 APE8-rot-out 19.51 APE67-dihe-in -74.38, -37.99 -51.24, -48.18 APE12-dist-in 9.515 APE11-dist-in 11.685 APE10-dist-in 5.909 APE9-dist-in 3.508 None SEP474 SEP474 XRAY 3.11 0.257 0.276 A 423 301 0 0 0 0 [[321, 572]] 1.0 4fie STE_PAK4_HUMAN STE 5.6e-88 300.6 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIEB O96013 49 590 591.0 ANP:1001 ATPlike Inactive DFGin 6.278 14.031 BLAminus -142.24, -177.62 63.59, 67.55 -92.7, 13.49 295.33, 98.22 -64.04, -7.21 in-out in 6.989 Saltbr-out 3.957 HRD-in -74.95, -36.21 66.97, -12.74 out-in-out SNCoio in-out ActLoopNT-in 2.857 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.0, 139.86 APE9-dihe-na 123.6, -177.41 APE8-dihe-in -84.57, 139.76 APE8-rot-out 19.62 APE67-dihe-in -74.42, -37.89 -51.19, -48.15 APE12-dist-in 9.515 APE11-dist-in 11.689 APE10-dist-in 5.912 APE9-dist-in 3.51 None SEP474 SEP474 XRAY 3.11 0.257 0.276 B 423 301 0 0 0 0 [[321, 572]] 1.0 4fie STE_PAK4_HUMAN STE 5.6e-88 300.6 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 7S46A O96013 300 589 591.0 ANP:600 ATPlike Active DFGin 9.021 14.349 BLAminus -133.61, -177.07 54.75, 76.68 -92.18, 14.46 286.49, 80.35 -59.04, -19.55 in-in in 7.534 Saltbr-in 2.867 HRD-in -69.43, -50.5 76.76, 2.96 in-in-in SNCiii in-in ActLoopNT-in 2.922 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.73, 132.58 APE9-dihe-na 145.82, -167.86 APE8-dihe-in -110.13, 128.57 APE8-rot-in 305.26 APE67-dihe-in -70.79, -21.11 -38.41, -55.32 APE12-dist-in 9.02 APE11-dist-in 11.537 APE10-dist-in 5.793 APE9-dist-in 3.286 D440N,S474E None None XRAY 2.1 0.182 0.22 A 346 290 0 0 0 0 [[321, 572]] 1.0 7s46 STE_PAK4_HUMAN STE 5.5e-87 297.4 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 7S47A O96013 300 589 591.0 ANP:600 ATPlike Active DFGin 9.217 14.646 BLAminus -126.8, -179.34 54.51, 73.91 -89.97, 15.41 285.81, 78.05 -59.21, -18.99 in-in in 7.79 Saltbr-in 2.931 HRD-in -66.64, -48.47 70.7, 6.89 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.53, 138.41 APE9-dihe-na 140.72, -164.27 APE8-dihe-in -114.61, 124.35 APE8-rot-in 304.9 APE67-dihe-in -66.22, -20.32 -36.39, -56.83 APE12-dist-in 9.039 APE11-dist-in 11.45 APE10-dist-in 5.747 APE9-dist-in 3.401 D440N,S474E None None XRAY 2.0 0.196 0.237 A 383 290 0 0 0 0 [[321, 572]] 1.0 7s47 STE_PAK4_HUMAN STE 7.5e-87 297.0 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIGB O96013 298 590 591.0 ANP:602 ATPlike Inactive DFGin 5.979 13.845 None -136.1, -40.27 -82.41, 70.29 -85.54, 12.48 305.29, 106.7 -66.77, -24.27 in-in in 7.007 Saltbr-in 3.047 HRD-in -63.37, -48.9 73.21, -4.05 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.8, 141.64 APE9-dihe-na 130.69, -165.45 APE8-dihe-in -110.43, 122.9 APE8-rot-in 324.7 APE67-dihe-in -77.33, -31.89 -29.23, -51.11 APE12-dist-in 9.706 APE11-dist-in 11.743 APE10-dist-in 5.92 APE9-dist-in 3.386 None SEP474 SEP474 XRAY 3.01 0.197 0.221 B 346 293 0 0 0 0 [[321, 572]] 1.0 4fig STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE STK24 STK24_HUMAN 4QMLA Q9Y6E0 30 310 443.0 ANP:60403 ATPlike Active DFGin 6.598 15.178 BLAminus -130.38, 172.22 70.9, 79.24 -104.53, 20.01 285.96, 83.16 -61.35, -25.21 in-in in 9.065 Saltbr-in 2.927 HRD-in -70.82, -51.82 74.23, -2.97 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.04, 155.96 APE9-dihe-na 125.92, -168.67 APE8-dihe-in -115.63, 119.31 APE8-rot-in 310.36 APE67-dihe-in -60.1, -29.49 -47.33, -42.77 APE12-dist-in 8.276 APE11-dist-in 11.051 APE10-dist-in 5.558 APE9-dist-in 3.386 None TPO190 TPO190 XRAY 1.882 0.19 0.23 A 310 281 0 0 0 0 [[36, 286]] 1.0 4qml STE_STK24_HUMAN STE 3.9e-100 340.4 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK3 STK3_HUMAN 6AO5A Q13188 28 488 491.0 ANP:501 ATPlike Inactive DFGin 5.762 13.255 BLAplus -144.87, 157.4 64.61, 76.09 -109.93, -46.63 13.82, 108.09 -89.31, 27.29 out-out out 12.908 Saltbr-out 12.116 HRD-in -60.56, -48.36 76.32, -35.33 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nooo APE10-dihe-na -164.34, 157.95 APE9-dihe-na -118.75, -167.2 APE8-dihe-in -63.94, 121.38 APE8-rot-out 166.95 APE67-dihe-out -86.4, -39.81 -115.82, 59.17 APE12-dist-none 999.0 APE11-dist-out 17.895 APE10-dist-out 16.152 APE9-dist-out 11.062 D146N None None XRAY 2.955 0.236 0.256 A 362 321 27 0 0 12 [[27, 278]] 1.0 6ao5 STE_STK3_HUMAN STE 3.6e-100 340.7 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 4LGDA Q13188 16 488 491.0 ANP:501 ATPlike Inactive DFGin 6.018 17.02 BLBminus -145.52, -179.3 43.95, 67.54 -70.27, 152.23 281.57, 44.13 -80.59, 163.91 out-out out 10.889 Saltbr-out 5.794 HRD-in -73.7, -41.12 68.58, 5.1 out-out-out SNCooo out-out ActLoopNT-out 8.717 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -60.16, -34.45 APE9-dihe-na -67.84, -18.95 APE8-dihe-in -138.32, 78.16 APE8-rot-in 307.08 APE67-dihe-in -67.01, -21.51 -99.04, 14.35 APE12-dist-in 12.457 APE11-dist-in 10.195 APE10-dist-out 15.269 APE9-dist-out 12.752 D146N None None XRAY 3.05 0.202 0.244 A 378 350 0 0 0 0 [[27, 278]] 1.0 4lgd STE_STK3_HUMAN STE 4.1e-100 340.6 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 4LGDB Q13188 10 488 491.0 ANP:501 ATPlike Inactive DFGin 6.16 16.692 BLBminus -138.64, 169.86 44.76, 62.12 -62.36, 151.89 285.61, 26.54 -88.9, 160.74 out-out out 10.736 Saltbr-out 6.022 HRD-in -77.36, -41.29 64.17, 12.1 out-out-out SNCooo out-out ActLoopNT-out 9.006 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -74.54, -22.15 APE9-dihe-na -64.82, -19.37 APE8-dihe-in -144.49, 84.11 APE8-rot-in 305.11 APE67-dihe-in -63.85, -34.86 -100.76, 15.67 APE12-dist-in 12.595 APE11-dist-in 10.253 APE10-dist-out 15.046 APE9-dist-out 12.722 D146N None None XRAY 3.05 0.202 0.244 B 378 350 0 0 0 0 [[27, 278]] 1.0 4lgd STE_STK3_HUMAN STE 4.1e-100 340.6 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 4LGDC Q13188 12 490 491.0 ANP:501 ATPlike Inactive DFGin 6.359 17.118 BLBminus -149.78, 166.61 51.14, 65.46 -62.65, 153.33 284.02, 26.74 -77.49, 169.34 out-out out 10.55 Saltbr-out 5.611 HRD-in -72.97, -46.37 72.83, -1.88 out-out-out SNCooo out-out ActLoopNT-out 9.037 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -57.36, -33.07 APE9-dihe-na -66.61, -18.79 APE8-dihe-in -138.0, 80.15 APE8-rot-in 301.29 APE67-dihe-in -70.28, -28.9 -100.7, 15.38 APE12-dist-in 12.447 APE11-dist-in 10.03 APE10-dist-out 15.197 APE9-dist-out 12.67 D146N None None XRAY 3.05 0.202 0.244 C 378 349 7 0 0 0 [[27, 278]] 1.0 4lgd STE_STK3_HUMAN STE 4.1e-100 340.6 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 4LGDD Q13188 11 489 491.0 ANP:501 ATPlike Inactive DFGin 6.268 16.891 BLBminus -143.39, 170.34 44.57, 62.98 -62.31, 161.36 279.47, 45.38 -101.43, 151.87 out-out out 10.794 Saltbr-out 6.287 HRD-in -67.38, -41.94 64.94, 10.19 out-out-out SNCooo out-out ActLoopNT-out 8.791 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -65.98, -30.48 APE9-dihe-na -65.09, -18.33 APE8-dihe-in -145.24, 79.51 APE8-rot-in 304.52 APE67-dihe-in -64.33, -26.69 -98.63, 11.94 APE12-dist-in 12.433 APE11-dist-in 10.306 APE10-dist-out 15.377 APE9-dist-out 12.751 D146N None None XRAY 3.05 0.202 0.244 D 378 338 0 0 0 0 [[27, 278]] 1.0 4lgd STE_STK3_HUMAN STE 4.1e-100 340.6 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STE STRADA STRAA_HUMAN 2WTKB Q7RTN6 61 431 431.0 ANP:432 ATPlike Pseudo DFGin 5.116 13.443 BLAminus -117.01, -150.73 71.3, 24.64 -54.34, -28.38 297.58, 14.45 -57.14, -26.88 out-none out 10.016 Saltbr-none 999.0 HRD-in -75.87, -56.89 78.73, -4.32 none-in-out SNCnio in-out ActLoopNT-in 2.921 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_iooo APE10-dihe-na -50.59, -53.43 APE9-dihe-na -67.53, -3.25 APE8-dihe-out -106.64, -20.66 APE8-rot-na 143.84 APE67-dihe-in -56.31, -21.98 -28.24, -53.75 APE12-dist-in 8.271 APE11-dist-out 7.456 APE10-dist-out 12.843 APE9-dist-out 9.371 None None None XRAY 2.65 0.24 0.291 B 373 311 52 0 0 0 [[69, 379]] 1.0 2wtk STE_STRADA_HUMAN STE 4e-87 298.0 1 257 257 212 213 214 216 218 100 118 122 192 194 193 195 261 247 242 241 240 239 238 237 236 148 STE20-related kinase adapter protein alpha
STE STRADA STRAA_HUMAN 2WTKE Q7RTN6 60 431 431.0 ANP:432 ATPlike Pseudo DFGin 5.076 13.591 BLAminus -114.47, -147.76 66.21, 35.38 -66.23, -19.97 288.54, 169.08 -50.33, -33.69 in-none in 9.934 Saltbr-none 999.0 HRD-in -67.35, -61.05 78.73, -1.12 none-in-out SNCnio in-out ActLoopNT-in 2.861 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_iooo APE10-dihe-na -48.76, -50.43 APE9-dihe-na -62.69, -41.12 APE8-dihe-out -68.21, -28.45 APE8-rot-na 167.78 APE67-dihe-in -49.8, -37.77 -23.43, -57.21 APE12-dist-in 8.119 APE11-dist-out 7.643 APE10-dist-out 12.951 APE9-dist-out 9.418 None None None XRAY 2.65 0.24 0.291 E 373 308 52 0 0 0 [[69, 379]] 1.0 2wtk STE_STRADA_HUMAN STE 4e-87 298.0 1 257 257 212 213 214 216 218 100 118 122 192 194 193 195 261 247 242 241 240 239 238 237 236 148 STE20-related kinase adapter protein alpha
STE TNIK TNIK_HUMAN 7XZRB Q9UKE5 12 312 1360.0 ANP:1401 ATPlike Active DFGin 6.439 15.163 BLAminus -131.61, 176.54 70.33, 83.31 -101.27, 21.61 286.01, 77.74 -67.8, -30.96 in-in in 9.126 Saltbr-in 2.582 HRD-in -64.36, -58.64 76.74, 3.35 in-in-in SNCiii in-in ActLoopNT-in 2.931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.27, 150.43 APE9-dihe-na 126.35, -168.16 APE8-dihe-in -105.07, 123.33 APE8-rot-in 308.43 APE67-dihe-in -61.4, -25.19 -44.62, -54.45 APE12-dist-in 8.7 APE11-dist-in 11.705 APE10-dist-in 6.078 APE9-dist-in 3.705 None TPO181,TPO187 TPO181,TPO187 XRAY 2.26 0.184 0.226 B 306 301 0 0 0 0 [[25, 289]] 1.0 7xzr STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 7XZRA Q9UKE5 12 310 1360.0 ANP:1401 Type1.5_Front Active DFGin 6.274 14.193 BLAminus -134.39, 177.59 74.52, 87.23 -110.98, 20.38 291.6, 89.06 -61.78, -40.23 in-in in 8.591 Saltbr-in 2.844 HRD-in -69.77, -51.11 71.86, 1.74 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.22, 154.28 APE9-dihe-na 131.69, -173.17 APE8-dihe-in -101.89, 120.07 APE8-rot-in 317.88 APE67-dihe-in -57.93, -30.58 -42.35, -51.61 APE12-dist-in 8.595 APE11-dist-in 12.046 APE10-dist-in 6.44 APE9-dist-in 4.307 None TPO181,TPO187 TPO181,TPO187 XRAY 2.26 0.184 0.226 A 306 299 0 0 0 0 [[25, 289]] 1.0 7xzr STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TKL ACVR1 ACVR1_HUMAN 6UNQA Q04771 206 496 509.0 ANP:501 ATPlike Inactive DFGin 7.42 13.337 BLAminus -125.65, 175.43 76.87, 82.94 -97.73, 22.73 293.77, 158.03 -74.66, -11.32 in-out in 8.409 Saltbr-out 4.371 HRD-in -82.52, -56.03 82.09, -4.01 out-in-out SNCoio in-out ActLoopNT-in 2.814 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.89, 171.23 APE9-dihe-na -69.6, 161.61 APE8-dihe-in -54.69, 120.18 APE8-rot-in 304.53 APE67-dihe-in -58.55, -27.57 -58.47, -38.91 APE12-dist-in 10.463 APE11-dist-out 6.668 APE10-dist-out 9.075 APE9-dist-in 3.923 K493A None None XRAY 2.4 0.221 0.283 A 330 289 3 0 0 0 [[207, 497]] 1.0 6unq TKL_ACVR1_HUMAN TKL 5e-85 291.3 2 266 265 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 6UNRA Q04771 208 496 509.0 ANP:501 ATPlike Inactive DFGin 7.292 13.342 BLAminus -137.01, 173.22 63.77, 86.25 -97.63, 26.62 300.72, 163.44 -66.11, -21.39 in-out in 8.4 Saltbr-out 4.744 HRD-in -74.93, -61.2 87.34, -7.73 out-in-out SNCoio in-out ActLoopNT-in 2.837 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -115.39, 160.07 APE9-dihe-na -63.13, 170.03 APE8-dihe-in -59.34, 121.87 APE8-rot-in 302.11 APE67-dihe-in -65.55, -35.42 -57.38, -33.57 APE12-dist-in 10.451 APE11-dist-out 6.838 APE10-dist-out 9.11 APE9-dist-in 3.93 None None None XRAY 2.2 0.246 0.302 A 330 286 4 0 0 0 [[207, 497]] 1.0 6unr TKL_ACVR1_HUMAN TKL 7.3e-85 290.8 2 266 265 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ARAF ARAF_HUMAN 9AXMB P10398 302 574 606.0 ANP:60602 ATPlike Inactive DFGin 4.597 13.327 BLBplus -134.26, 172.61 61.7, 46.72 -103.54, 150.88 54.31, 89.4 54.71, 36.64 out-out out 11.556 Saltbr-out 10.494 HRD-in -66.55, -46.59 76.65, -12.19 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -153.94 APE8-dihe-in -77.25, 142.54 APE8-rot-out 182.59 APE67-dihe-in -67.09, -22.55 -72.82, -26.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.524 Y301D,Y302D None None XRAY 2.42 0.263 0.301 B 280 254 19 0 0 17 [[310, 569]] 1.0 9axm TKL_ARAF_HUMAN TKL 1.1e-77 267.1 2 266 265 446 447 448 450 452 336 354 358 426 428 427 429 491 476 471 470 469 468 467 466 465 383 Serine/threonine-protein kinase A-Raf
TKL BRAF BRAF_HUMAN 9AXXB P15056 449 721 766.0 ANP:60801 ATPlike Inactive DFGin 6.272 14.156 BLAminus -118.96, -160.68 44.13, 79.21 -91.3, 29.71 285.28, 70.2 -64.85, -24.03 in-out in 8.968 Saltbr-out 6.042 HRD-in -74.42, -44.59 66.93, 5.21 out-in-in SNCoii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.1, 120.32 APE9-dihe-na 137.74, -165.97 APE8-dihe-in -102.01, 122.38 APE8-rot-in 304.65 APE67-dihe-in -63.13, -30.61 -66.04, -26.1 APE12-dist-in 13.099 APE11-dist-in 12.628 APE10-dist-in 7.472 APE9-dist-in 5.708 None None None XRAY 2.07 0.215 0.248 B 280 261 12 0 0 6 [[457, 716]] 1.0 9axx TKL_BRAF_HUMAN TKL 7.8e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 9AXYA P15056 448 722 766.0 ANP:801 ATPlike Inactive DFGin 5.917 13.541 BLBplus -133.51, 174.13 59.27, 33.71 -86.77, 154.56 49.71, 87.92 69.37, -142.48 out-out out 14.096 Saltbr-out 13.007 HRD-in -70.93, -41.64 75.57, -39.02 out-out-out SNCooo out-out ActLoopNT-out 9.069 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -141.06, 145.96 APE9-dihe-na 71.75, -130.61 APE8-dihe-in -87.56, 149.58 APE8-rot-out 200.58 APE67-dihe-in -69.57, -29.74 -96.77, -9.15 APE12-dist-out 14.194 APE11-dist-out 15.515 APE10-dist-out 11.663 APE9-dist-out 9.677 None None None XRAY 3.6 0.19 0.237 A 280 275 0 0 0 0 [[457, 716]] 1.0 9axy TKL_BRAF_HUMAN TKL 7.8e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 6PP9A P15056 447 722 766.0 ANP:801 ATPlike Inactive DFGin 5.342 13.498 BLBplus -130.79, 177.54 57.37, 43.96 -96.57, 156.54 49.86, 89.0 63.47, -135.71 out-out out 14.313 Saltbr-out 12.69 HRD-in -66.97, -47.8 65.51, 3.6 out-out-out SNCooo out-out ActLoopNT-out 9.256 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -142.44, 146.23 APE9-dihe-na 73.26, -154.57 APE8-dihe-in -71.36, 154.2 APE8-rot-out 182.15 APE67-dihe-in -61.64, -19.53 -112.25, -5.75 APE12-dist-out 15.201 APE11-dist-out 15.9 APE10-dist-out 12.693 APE9-dist-out 10.139 None None None XRAY 2.59 0.222 0.245 A 283 276 0 0 0 0 [[457, 716]] 1.0 6pp9 TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 6V2WA P15056 447 721 766.0 ANP:801 ATPlike Inactive DFGin 5.532 13.704 BLBplus -135.72, 175.83 57.63, 35.46 -91.96, 158.82 53.8, 96.09 64.15, -137.39 out-out out 14.475 Saltbr-out 12.433 HRD-in -69.37, -44.53 66.04, 8.13 out-out-out SNCooo out-out ActLoopNT-out 8.99 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -146.39, 170.31 APE9-dihe-na 111.41, -172.95 APE8-dihe-in -92.84, 135.37 APE8-rot-out 52.69 APE67-dihe-in -65.1, -26.74 -72.43, -22.76 APE12-dist-out 14.729 APE11-dist-out 14.898 APE10-dist-out 12.159 APE9-dist-out 6.256 None None None XRAY 3.12 0.189 0.237 A 283 275 0 0 0 0 [[457, 716]] 1.0 6v2w TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0TA P15056 448 721 766.0 ANP:801 ATPlike Inactive DFGin 5.483 13.645 BLBplus -101.53, -171.54 49.12, 40.35 -93.39, 158.36 49.68, 91.24 67.74, -141.33 out-out out 14.633 Saltbr-out 13.418 HRD-in -63.36, -50.98 81.19, -14.99 out-out-out SNCooo out-out ActLoopNT-out 9.096 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iooo APE10-dihe-na -146.63, 169.35 APE9-dihe-na 113.78, -178.56 APE8-dihe-in -87.12, 141.18 APE8-rot-out 208.64 APE67-dihe-out -59.38, 160.81 -70.93, -34.96 APE12-dist-in 13.663 APE11-dist-out 15.277 APE10-dist-out 12.449 APE9-dist-out 6.689 None None None XRAY 3.19 0.199 0.254 A 283 274 0 0 0 0 [[457, 716]] 1.0 7m0t TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0UA P15056 449 722 766.0 ANP:801 ATPlike Inactive DFGin 5.826 13.545 BLBplus -114.76, -174.76 53.19, 33.71 -86.73, 158.23 49.19, 93.22 61.58, -136.88 out-out out 14.508 Saltbr-out 13.628 HRD-in -66.62, -51.93 79.28, -5.3 out-out-out SNCooo out-out ActLoopNT-out 8.968 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -137.94, 171.17 APE9-dihe-na 125.59, 173.92 APE8-dihe-in -78.53, 136.46 APE8-rot-out 49.62 APE67-dihe-in -63.36, -26.84 -75.55, -22.51 APE12-dist-out 14.59 APE11-dist-out 14.476 APE10-dist-out 12.102 APE9-dist-out 6.331 None None None XRAY 3.09 0.193 0.23 A 283 274 0 0 0 0 [[457, 716]] 1.0 7m0u TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0VA P15056 449 722 766.0 ANP:801 ATPlike Inactive DFGin 5.741 13.29 BLBplus -118.84, -178.01 61.17, 44.22 -99.98, 160.93 40.29, 99.45 62.33, -140.62 out-out out 14.111 Saltbr-out 13.141 HRD-in -76.68, -47.66 79.51, -34.29 out-out-out SNCooo out-out ActLoopNT-out 9.324 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -140.71, 145.59 APE9-dihe-na 81.77, -131.39 APE8-dihe-in -106.29, 148.31 APE8-rot-out 201.4 APE67-dihe-in -54.29, -30.39 -107.29, -13.89 APE12-dist-in 13.909 APE11-dist-out 15.777 APE10-dist-out 12.613 APE9-dist-out 10.163 None None None XRAY 3.16 0.188 0.234 A 283 274 0 0 0 0 [[457, 716]] 1.0 7m0v TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0WA P15056 448 721 766.0 ANP:801 ATPlike Inactive DFGin 5.7 13.563 BLBplus -128.57, -174.24 58.52, 36.11 -93.32, 163.98 47.26, 91.72 57.0, -141.37 out-out out 14.273 Saltbr-out 13.044 HRD-in -64.47, -50.11 78.2, -6.17 out-out-out SNCooo out-out ActLoopNT-out 8.98 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -140.16, 158.71 APE9-dihe-na 121.26, -178.69 APE8-dihe-in -87.94, 138.93 APE8-rot-out 43.99 APE67-dihe-in -65.6, -30.89 -79.08, -13.62 APE12-dist-out 14.335 APE11-dist-out 15.342 APE10-dist-out 12.134 APE9-dist-out 6.651 None None None XRAY 3.09 0.197 0.233 A 283 274 0 0 0 0 [[457, 716]] 1.0 7m0w TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0XA P15056 447 722 766.0 ANP:801 ATPlike Inactive DFGin 5.445 13.495 BLBplus -123.82, 174.92 60.79, 42.33 -96.45, 161.16 49.04, 90.67 58.85, -140.33 out-out out 14.265 Saltbr-out 13.063 HRD-in -65.53, -50.34 78.03, -10.0 out-out-out SNCooo out-out ActLoopNT-out 9.245 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -141.24, 149.26 APE9-dihe-na 65.43, -162.66 APE8-dihe-in -61.59, 142.77 APE8-rot-out 179.57 APE67-dihe-in -62.52, -26.23 -97.92, -3.07 APE12-dist-out 15.152 APE11-dist-out 15.966 APE10-dist-out 12.626 APE9-dist-out 10.084 None None None XRAY 2.47 0.18 0.215 A 283 276 0 0 0 0 [[457, 716]] 1.0 7m0x TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0YA P15056 447 721 766.0 ANP:801 ATPlike Inactive DFGin 5.925 13.72 BLBplus -130.12, 178.08 53.67, 39.87 -94.09, 143.26 51.07, 86.66 77.46, -140.33 out-out out 14.454 Saltbr-out 12.42 HRD-in -66.6, -53.86 81.89, -14.1 out-out-out SNCooo out-out ActLoopNT-out 8.968 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -138.96, 162.77 APE9-dihe-na 110.62, -175.34 APE8-dihe-in -77.87, 138.5 APE8-rot-out 52.44 APE67-dihe-in -64.93, -32.89 -83.52, -17.07 APE12-dist-out 14.226 APE11-dist-out 15.27 APE10-dist-out 12.007 APE9-dist-out 6.781 None None None XRAY 3.45 0.196 0.218 A 283 275 0 0 0 0 [[457, 716]] 1.0 7m0y TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0ZA P15056 449 721 766.0 ANP:801 ATPlike Inactive DFGin 5.591 13.558 BLBplus -131.23, -177.35 57.24, 31.09 -88.02, 155.4 49.99, 89.35 66.37, -137.56 out-out out 14.378 Saltbr-out 12.797 HRD-in -63.1, -49.11 70.7, -2.29 out-out-out SNCooo out-out ActLoopNT-out 8.934 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -140.88, 158.66 APE9-dihe-na 126.45, -167.01 APE8-dihe-in -93.79, 132.25 APE8-rot-out 208.38 APE67-dihe-in -66.35, -24.31 -75.16, -20.55 APE12-dist-in 12.987 APE11-dist-out 14.918 APE10-dist-out 11.822 APE9-dist-out 6.385 None None None XRAY 3.12 0.193 0.225 A 283 273 0 0 0 0 [[457, 716]] 1.0 7m0z TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 9ECUA P15056 447 722 766.0 ANP:801 ATPlike Inactive DFGin 5.395 13.556 BLBplus -125.65, 169.46 60.46, 40.01 -87.45, 154.95 47.27, 91.45 64.75, -132.56 out-out out 13.975 Saltbr-out 13.736 HRD-in -64.53, -58.29 87.19, -19.63 out-out-out SNCooo out-out ActLoopNT-out 9.233 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -128.75, 123.72 APE9-dihe-na 163.56, -169.21 APE8-dihe-in -104.16, 118.8 APE8-rot-in 298.64 APE67-dihe-in -60.82, -35.98 -59.26, -34.28 APE12-dist-out 14.691 APE11-dist-out 15.132 APE10-dist-out 11.51 APE9-dist-out 6.31 None None None XRAY 3.46 0.202 0.237 A 284 276 0 0 0 0 [[457, 716]] 1.0 9ecu TKL_BRAF_HUMAN TKL 8.2e-82 280.6 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL IRAK4 IRAK4_HUMAN 2OIDA Q9NWZ3 164 458 460.0 ANP:1 ATPlike Inactive DFGin 6.966 14.684 BLAminus -127.55, 175.38 65.24, 82.27 -102.22, 23.11 306.08, 83.19 -64.75, -29.47 out-out out 11.832 Saltbr-out 5.69 HRD-in -73.12, -50.9 80.09, -6.55 out-in-in SNCoii in-in ActLoopNT-in 2.823 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.88, 151.66 APE9-dihe-na 147.16, -164.5 APE8-dihe-in -113.74, 115.19 APE8-rot-in 308.34 APE67-dihe-in -64.44, -17.27 -37.39, -54.71 APE12-dist-in 9.826 APE11-dist-in 11.538 APE10-dist-in 6.072 APE9-dist-in 3.807 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.244 0.295 A 301 266 29 0 0 4 [[183, 456]] 1.0 2oid TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OIDB Q9NWZ3 164 459 460.0 ANP:2 ATPlike Inactive DFGin 6.94 14.71 BLAminus -122.34, 171.98 72.6, 82.12 -104.43, 15.54 299.16, 90.11 -59.64, -29.05 in-out in 8.908 Saltbr-out 3.93 HRD-in -75.58, -47.6 78.52, -5.87 out-in-in SNCoii in-in ActLoopNT-in 2.73 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.71, 158.05 APE9-dihe-na 142.8, -157.21 APE8-dihe-in -121.23, 117.8 APE8-rot-in 309.19 APE67-dihe-in -67.67, -11.87 -44.28, -49.35 APE12-dist-in 10.19 APE11-dist-in 11.743 APE10-dist-in 6.522 APE9-dist-in 3.723 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.244 0.295 B 301 274 22 0 0 6 [[183, 456]] 1.0 2oid TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OIDC Q9NWZ3 166 458 460.0 ANP:3 ATPlike Inactive DFGin 6.806 13.973 BLAminus -130.4, 175.52 61.07, 75.53 -96.05, 32.37 309.84, 82.72 -74.67, -28.22 in-out in 8.901 Saltbr-out 4.024 HRD-in -62.6, -55.98 80.8, 1.53 out-in-in SNCoii in-in ActLoopNT-in 3.032 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.92, 158.28 APE9-dihe-na 138.01, -176.06 APE8-dihe-in -106.21, 116.22 APE8-rot-in 304.08 APE67-dihe-in -63.21, -15.57 -55.27, -41.4 APE12-dist-in 9.687 APE11-dist-in 11.42 APE10-dist-in 6.361 APE9-dist-in 3.878 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.244 0.295 C 301 259 34 0 0 6 [[183, 456]] 1.0 2oid TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OIDD Q9NWZ3 164 459 460.0 ANP:4 ATPlike Active DFGin 6.56 13.972 BLAminus -129.12, -177.03 59.13, 109.88 -131.38, 17.54 304.54, 87.5 -68.37, -4.63 in-in in 8.15 Saltbr-in 3.52 HRD-in -75.54, -51.34 70.58, 2.03 in-in-in SNCiii in-in ActLoopNT-in 2.765 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.72, 147.52 APE9-dihe-na 139.0, -173.6 APE8-dihe-in -107.1, 118.58 APE8-rot-in 309.04 APE67-dihe-in -62.68, -15.82 -47.4, -49.91 APE12-dist-in 9.75 APE11-dist-in 11.44 APE10-dist-in 5.928 APE9-dist-in 3.97 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.244 0.295 D 301 277 19 0 0 3 [[183, 456]] 1.0 2oid TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6EGFB Q9NWZ3 164 460 460.0 ANP:501 ATPlike Inactive DFGin 5.613 16.883 BLBtrans -116.63, 167.73 64.0, 27.84 -68.07, 138.11 161.96, 71.15 80.16, -16.86 out-out out 13.646 Saltbr-out 13.39 HRD-in -72.08, -42.87 70.74, 1.24 out-out-out SNCooo out-out ActLoopNT-out 6.113 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 31.47 APE8-rot-out 178.98 APE67-dihe-in -65.08, -16.47 -76.23, -17.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.61 0.206 0.229 B 302 285 12 0 0 12 [[183, 456]] 1.0 6egf TKL_IRAK4_HUMAN TKL 2.6e-83 285.5 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL KSR1 KSR1_HUMAN 9AXHC Q8IVT5 614 881 923.0 ANP:60901 ATPlike Pseudo DFGin 5.23 13.239 BLBplus -124.42, 164.81 64.66, 43.46 -90.48, 143.73 53.91, 91.43 61.22, 55.23 out-none out 14.31 Saltbr-none 999.0 HRD-in -67.1, -51.8 77.02, -11.89 none-out-out SNCnoo out-out ActLoopNT-out 7.657 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -64.2, -39.05 APE9-dihe-na -59.17, -48.89 APE8-dihe-out -66.09, -38.64 APE8-rot-na 184.07 APE67-dihe-in -61.76, -22.42 -60.74, -36.73 APE12-dist-out 16.89 APE11-dist-out 15.959 APE10-dist-out 20.499 APE9-dist-out 12.219 None None None XRAY 2.81 0.206 0.253 C 283 259 10 0 0 7 [[613, 879]] 1.0 9axh TKL_KSR1_HUMAN TKL 2.1e-68 236.7 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 9AXHD Q8IVT5 613 881 923.0 ANP:60901 ATPlike Pseudo DFGin 5.246 13.229 BLBplus -126.56, 169.35 63.03, 47.69 -96.52, 141.09 54.28, 88.59 76.52, 29.36 out-none out 14.488 Saltbr-none 999.0 HRD-in -67.9, -47.78 73.32, -2.62 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -60.7, -40.23 APE9-dihe-na -60.83, -42.14 APE8-dihe-out -70.49, -38.33 APE8-rot-na 183.99 APE67-dihe-in -64.38, -16.08 -60.51, -36.42 APE12-dist-out 17.087 APE11-dist-out 16.228 APE10-dist-out 20.701 APE9-dist-out 12.597 None None None XRAY 2.81 0.206 0.253 D 283 249 20 0 0 13 [[613, 879]] 1.0 9axh TKL_KSR1_HUMAN TKL 2.1e-68 236.7 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JUWB Q8IVT5 601 881 923.0 ANP:901 ATPlike Pseudo DFGin 5.479 13.436 BLBplus -116.78, 175.7 58.02, 37.9 -91.13, 161.87 61.57, 85.28 62.4, -8.11 out-none out 13.34 Saltbr-none 999.0 HRD-in -64.36, -50.52 68.6, 3.9 none-out-out SNCnoo out-out ActLoopNT-out 7.126 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -75.12, -46.44 APE9-dihe-na -49.25, -41.63 APE8-dihe-out -65.16, -50.29 APE8-rot-na 182.96 APE67-dihe-in -55.58, -30.38 -61.8, -31.6 APE12-dist-out 17.682 APE11-dist-out 16.599 APE10-dist-out 21.026 APE9-dist-out 12.834 None None None XRAY 2.88 0.245 0.286 B 334 277 4 0 0 4 [[613, 879]] 1.0 7juw TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JUXA Q8IVT5 600 881 923.0 ANP:901 ATPlike Pseudo DFGin 5.302 12.887 BLBplus -130.76, 153.55 60.79, 41.41 -77.85, 152.64 59.13, 80.46 58.16, 12.6 out-none out 13.586 Saltbr-none 999.0 HRD-out -82.48, 84.18 -62.97, 148.26 none-out-out SNCnoo out-out ActLoopNT-out 7.062 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -85.2, -42.07 APE9-dihe-na -55.8, -29.41 APE8-dihe-out -77.82, -37.67 APE8-rot-na 188.53 APE67-dihe-in -61.89, -19.45 -62.94, -36.24 APE12-dist-out 17.427 APE11-dist-out 16.235 APE10-dist-out 20.624 APE9-dist-out 14.057 None None None XRAY 3.34 0.265 0.283 A 334 278 4 0 0 4 [[613, 879]] 1.0 7jux TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JUYB Q8IVT5 601 881 923.0 ANP:901 ATPlike Pseudo DFGin 5.613 13.191 BLBplus -117.18, 175.18 57.71, 38.02 -91.22, 161.18 61.47, 85.63 62.09, -7.96 out-none out 13.395 Saltbr-none 999.0 HRD-in -64.77, -50.93 68.2, 3.89 none-out-out SNCnoo out-out ActLoopNT-out 7.067 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -74.87, -46.12 APE9-dihe-na -49.26, -41.38 APE8-dihe-out -64.88, -49.41 APE8-rot-na 183.95 APE67-dihe-in -56.03, -30.73 -61.35, -31.75 APE12-dist-out 17.556 APE11-dist-out 16.525 APE10-dist-out 20.947 APE9-dist-out 12.77 None None None XRAY 3.096 0.248 0.257 B 334 276 5 0 0 5 [[613, 879]] 1.0 7juy TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JUZA Q8IVT5 601 881 923.0 ANP:901 ATPlike Pseudo DFGin 5.251 13.144 BLBplus -120.58, 157.85 65.97, 36.71 -81.68, 149.84 60.82, 87.44 61.36, 0.32 out-none out 13.842 Saltbr-none 999.0 HRD-in -63.05, -49.06 69.65, 1.96 none-out-out SNCnoo out-out ActLoopNT-out 6.963 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -71.77, -43.35 APE9-dihe-na -54.66, -39.8 APE8-dihe-out -69.49, -39.39 APE8-rot-na 184.11 APE67-dihe-in -64.95, -32.88 -59.75, -32.59 APE12-dist-out 17.573 APE11-dist-out 16.418 APE10-dist-out 20.831 APE9-dist-out 12.592 None None None XRAY 3.21 0.255 0.272 A 334 273 8 0 0 8 [[613, 879]] 1.0 7juz TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JV0A Q8IVT5 601 881 923.0 ANP:901 ATPlike Pseudo DFGin 5.544 13.231 BLBplus -113.37, 179.62 53.84, 36.37 -87.67, 157.34 63.1, 86.33 73.66, -16.65 out-none out 13.335 Saltbr-none 999.0 HRD-in -63.7, -53.29 73.57, 2.92 none-out-out SNCnoo out-out ActLoopNT-out 7.005 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -74.36, -44.01 APE9-dihe-na -53.64, -41.33 APE8-dihe-out -66.6, -51.73 APE8-rot-na 184.61 APE67-dihe-in -59.37, -29.99 -47.75, -40.44 APE12-dist-out 17.632 APE11-dist-out 16.659 APE10-dist-out 21.083 APE9-dist-out 12.781 None None None XRAY 3.63 0.247 0.26 A 334 276 5 0 0 5 [[613, 879]] 1.0 7jv0 TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JV1D Q8IVT5 600 881 923.0 ANP:901 ATPlike Pseudo DFGin 4.998 13.028 BLBplus -130.92, 154.93 60.0, 40.35 -76.18, 155.67 58.85, 79.94 54.95, 12.06 out-none out 13.786 Saltbr-none 999.0 HRD-out -81.07, 84.18 -62.62, 147.5 none-out-out SNCnoo out-out ActLoopNT-out 6.808 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -83.95, -45.7 APE9-dihe-na -55.75, -29.37 APE8-dihe-out -76.69, -37.65 APE8-rot-na 188.09 APE67-dihe-in -60.65, -19.03 -62.72, -36.82 APE12-dist-out 17.487 APE11-dist-out 16.348 APE10-dist-out 20.808 APE9-dist-out 14.145 None None None XRAY 3.62 0.278 0.303 D 334 275 7 0 0 7 [[613, 879]] 1.0 7jv1 TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR2 KSR2_HUMAN 7JURB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.534 13.444 BLBplus -136.74, 172.29 64.43, 21.01 -64.29, 145.08 51.43, 88.21 72.32, -17.93 out-none out 13.058 Saltbr-none 999.0 HRD-in -74.46, -55.37 71.55, 3.38 none-out-out SNCnoo out-out ActLoopNT-out 7.607 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -61.97, 131.45 APE9-dihe-na 84.3, -3.37 APE8-dihe-out -70.0, -57.71 APE8-rot-na 184.79 APE67-dihe-in -71.0, 1.52 -53.02, -42.72 APE12-dist-out 18.483 APE11-dist-out 15.136 APE10-dist-out 19.742 APE9-dist-out 12.323 None None None XRAY 2.82 0.237 0.277 B 342 277 4 0 0 3 [[665, 930]] 1.0 7jur TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JUSB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.883 13.383 BLBplus -127.91, 171.08 62.77, 22.74 -63.47, 150.27 47.2, 86.11 68.89, -21.25 out-none out 13.513 Saltbr-none 999.0 HRD-in -73.66, -56.88 73.44, -2.22 none-out-out SNCnoo out-out ActLoopNT-out 7.508 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -57.38, 137.79 APE9-dihe-na 90.37, -24.33 APE8-dihe-out -66.74, -57.02 APE8-rot-na 187.61 APE67-dihe-in -75.11, -1.38 -58.95, -34.29 APE12-dist-out 18.421 APE11-dist-out 15.077 APE10-dist-out 19.629 APE9-dist-out 12.036 None None None XRAY 2.99 0.249 0.265 B 342 276 5 0 0 4 [[665, 930]] 1.0 7jus TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JUTB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.556 12.961 BLBplus -137.17, 153.82 70.92, 32.74 -74.86, 135.77 48.5, 88.18 74.13, -4.82 out-none out 14.209 Saltbr-none 999.0 HRD-in -85.35, -39.03 46.26, 13.05 none-out-out SNCnoo out-out ActLoopNT-out 7.196 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -53.57, -55.36 APE9-dihe-na -91.09, 3.18 APE8-dihe-out -71.8, -46.41 APE8-rot-na 181.21 APE67-dihe-in -68.18, -7.53 -62.86, -41.09 APE12-dist-out 18.127 APE11-dist-out 15.431 APE10-dist-out 19.558 APE9-dist-out 11.925 None None None XRAY 3.09 0.259 0.3 B 342 277 4 0 0 3 [[665, 930]] 1.0 7jut TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JUUB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.773 13.221 BLBplus -133.64, 151.36 70.73, 33.64 -75.25, 133.98 46.29, 83.15 80.08, -8.46 out-none out 14.433 Saltbr-none 999.0 HRD-in -73.56, -47.69 67.59, 2.06 none-out-out SNCnoo out-out ActLoopNT-out 7.385 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -58.47, -51.54 APE9-dihe-na -86.76, 0.87 APE8-dihe-out -74.62, -44.43 APE8-rot-na 183.38 APE67-dihe-in -73.96, -6.37 -64.52, -36.97 APE12-dist-out 18.347 APE11-dist-out 15.59 APE10-dist-out 19.794 APE9-dist-out 12.093 None None None XRAY 3.19 0.242 0.258 B 342 277 4 0 0 3 [[665, 930]] 1.0 7juu TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JUVB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.981 13.017 BLBplus -127.69, 170.94 63.29, 22.28 -64.16, 148.8 47.81, 86.58 68.48, -22.21 out-none out 13.605 Saltbr-none 999.0 HRD-in -73.05, -56.86 73.65, -2.34 none-out-out SNCnoo out-out ActLoopNT-out 7.503 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -57.84, 138.27 APE9-dihe-na 90.88, -24.23 APE8-dihe-out -67.14, -55.82 APE8-rot-na 188.73 APE67-dihe-in -75.46, -2.03 -58.92, -34.4 APE12-dist-out 18.296 APE11-dist-out 15.175 APE10-dist-out 19.835 APE9-dist-out 12.199 None None None XRAY 3.36 0.242 0.255 B 342 277 4 0 0 3 [[665, 930]] 1.0 7juv TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7UMBB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.511 13.333 BLBplus -122.69, -178.17 55.62, 31.28 -75.96, 141.02 47.41, 88.89 74.01, -10.38 out-none out 13.077 Saltbr-none 999.0 HRD-in -83.2, -50.32 69.21, 5.46 none-out-out SNCnoo out-out ActLoopNT-out 7.53 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -52.68, 124.31 APE9-dihe-na 106.73, -20.32 APE8-dihe-out -71.55, -49.08 APE8-rot-na 185.38 APE67-dihe-in -79.33, 2.43 -65.58, -32.18 APE12-dist-out 18.119 APE11-dist-out 15.398 APE10-dist-out 19.723 APE9-dist-out 12.009 None None None XRAY 3.231 0.231 0.268 B 342 277 4 0 0 3 [[665, 930]] 1.0 7umb TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL LIMK1 LIMK1_HUMAN 5HVJA P53667 329 633 647.0 ANP:1000 ATPlike Inactive DFGin 6.167 14.018 BLAminus -132.74, -177.4 60.53, 87.07 -109.1, 23.76 308.69, 90.48 -66.78, -25.98 in-in in 8.119 Saltbr-in 2.787 HRD-in -65.97, -50.93 68.53, 0.88 in-in-out SNCiio in-out ActLoopNT-in 2.943 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oiio APE10-dihe-na -124.58, 95.6 APE9-dihe-na 76.06, -115.03 APE8-dihe-in -111.26, 122.06 APE8-rot-na 224.18 APE67-dihe-in -69.88, -30.27 -73.34, -10.37 APE12-dist-out 14.758 APE11-dist-in 11.813 APE10-dist-in 6.925 APE9-dist-out 6.372 D460N None None XRAY 2.2 0.208 0.252 A 315 283 22 0 0 22 [[339, 606]] 1.0 5hvj TKL_LIMK1_HUMAN TKL 3e-76 262.4 3 266 264 477 478 479 481 483 368 384 388 457 459 458 460 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL LIMK1 LIMK1_HUMAN 5HVKA P53667 329 634 647.0 ANP:61001 ATPlike Active DFGin 6.405 13.646 BLAminus -145.46, 176.84 65.07, 82.49 -109.26, 24.73 304.62, 92.73 -71.79, -22.73 in-in in 7.795 Saltbr-in 3.159 HRD-in -70.8, -44.42 59.42, 18.52 in-in-in SNCiii in-in ActLoopNT-in 3.324 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -139.63, 151.17 APE9-dihe-na 143.88, 171.7 APE8-dihe-in -71.51, 120.27 APE8-rot-na 199.31 APE67-dihe-in -66.59, -36.22 -54.03, -34.34 APE12-dist-in 9.301 APE11-dist-in 11.081 APE10-dist-in 5.636 APE9-dist-in 3.574 D460N TPO508 TPO508 XRAY 3.5 0.275 0.31 A 315 293 13 0 0 13 [[339, 606]] 1.0 5hvk TKL_LIMK1_HUMAN TKL 3e-76 262.4 3 266 264 477 478 479 481 483 368 384 388 457 459 458 460 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL LIMK1 LIMK1_HUMAN 5HVKC P53667 329 633 647.0 ANP:60701 ATPlike Inactive DFGin 6.078 13.934 None -149.69, 172.69 -101.87, 169.41 -110.21, 23.25 306.34, 92.8 -73.91, -25.16 in-out in 7.891 Saltbr-out 3.644 HRD-in -72.39, -44.63 59.79, 17.6 out-in-in SNCoii in-in ActLoopNT-in 3.07 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -140.53, 148.22 APE9-dihe-na 140.89, 172.08 APE8-dihe-in -72.12, 119.75 APE8-rot-na 199.66 APE67-dihe-in -64.48, -35.33 -54.5, -33.22 APE12-dist-in 8.669 APE11-dist-in 11.199 APE10-dist-in 5.899 APE9-dist-in 3.542 D460N TPO508 TPO508 XRAY 3.5 0.275 0.31 C 315 291 14 0 0 14 [[339, 606]] 1.0 5hvk TKL_LIMK1_HUMAN TKL 3e-76 262.4 3 266 264 477 478 479 481 483 368 384 388 457 459 458 460 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL LRRK2 LRRK2_HUMAN 8VH5A Q5S007 12 2527 2527.0 ANP:2602 ATPlike Inactive DFGinter 9.746 8.455 None -88.01, 106.84 -81.35, 17.64 -78.83, -10.5 197.42, 64.93 -68.71, -22.79 out-out out 11.326 Saltbr-out 8.123 HRD-in -105.05, -49.61 72.56, -5.72 out-out-out SNCooo out-out ActLoopNT-out 8.961 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -67.06, -23.38 APE9-dihe-na 73.72, 168.0 APE8-dihe-in -68.8, 143.98 APE8-rot-out 58.99 APE67-dihe-in -65.74, -54.3 -73.05, -29.17 APE12-dist-in 9.633 APE11-dist-in 8.416 APE10-dist-out 13.344 APE9-dist-in 3.861 None None None EM 4.0 999.0 999.0 A 2527 2221 8 0 0 8 [[1875, 2134]] 1.0 8vh5 TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8VH5C Q5S007 12 2527 2527.0 ANP:2602 ATPlike Inactive DFGinter 9.746 8.455 None -88.01, 106.86 -81.36, 17.7 -78.84, -10.6 197.4, 64.92 -68.66, -22.76 out-out out 11.325 Saltbr-out 8.122 HRD-in -104.99, -49.63 72.52, -5.67 out-out-out SNCooo out-out ActLoopNT-out 8.961 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -66.98, -23.42 APE9-dihe-na 73.64, 168.02 APE8-dihe-in -68.73, 143.93 APE8-rot-out 59.0 APE67-dihe-in -65.76, -54.24 -73.07, -29.13 APE12-dist-in 9.633 APE11-dist-in 8.418 APE10-dist-out 13.345 APE9-dist-in 3.862 None None None EM 4.0 999.0 999.0 C 2527 2221 8 0 0 8 [[1875, 2134]] 1.0 8vh5 TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8VH4A Q5S007 12 2527 2527.0 ANP:2602 ATPlike Inactive None 999.0 999.0 None -94.14, 87.28 -74.17, 5.0 -60.35, -20.37 999.0, 999.0 -59.12, -33.8 out-none out 12.056 Saltbr-none 999.0 HRD-in -102.88, -51.08 73.15, -5.33 none-out-out SNCnoo out-out ActLoopNT-out 8.75 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -76.21, -33.07 APE9-dihe-na 74.7, 171.21 APE8-dihe-in -59.82, 149.42 APE8-rot-out 184.58 APE67-dihe-in -66.4, -59.35 -67.96, -43.48 APE12-dist-in 10.222 APE11-dist-in 9.448 APE10-dist-out 13.491 APE9-dist-in 4.057 None None None EM 4.1 999.0 999.0 A 2527 2235 8 0 0 8 [[1875, 2134]] 1.0 8vh4 TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL RAF1 RAF1_HUMAN 9AY7A P04049 343 612 648.0 ANP:701 ATPlike Inactive DFGin 5.805 13.462 BLBplus -133.55, 174.37 58.47, 38.44 -90.49, 142.18 44.05, 90.72 78.29, -134.9 out-out out 14.07 Saltbr-out 12.738 HRD-in -73.02, -44.7 76.86, -25.12 out-out-out SNCooo out-out ActLoopNT-out 9.182 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -145.48, 130.61 APE9-dihe-na 129.03, -169.57 APE8-dihe-in -79.63, 137.79 APE8-rot-in 302.79 APE67-dihe-in -63.4, -34.24 -69.33, -38.68 APE12-dist-out 15.236 APE11-dist-out 15.056 APE10-dist-out 10.624 APE9-dist-out 6.306 Y340D,Y341D None None XRAY 2.41 0.203 0.236 A 280 260 10 0 0 6 [[349, 608]] 1.0 9ay7 TKL_RAF1_HUMAN TKL 2.6e-81 279.0 3 266 264 485 486 487 489 491 375 393 397 465 467 466 468 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
TKL TGFBR2 TGFR2_HUMAN 5E92A P37173 240 543 567.0 ANP:601 ATPlike Active DFGin 7.396 13.303 BLAminus -134.93, 178.1 63.07, 87.04 -105.26, 16.76 300.78, 96.96 -60.58, -26.14 in-in in 7.67 Saltbr-in 2.752 HRD-in -64.87, -46.8 71.14, -4.53 in-in-in SNCiii in-in ActLoopNT-in 2.982 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.21, 144.17 APE9-dihe-na 126.96, -149.92 APE8-dihe-in -116.55, 119.38 APE8-rot-in 300.41 APE67-dihe-in -54.91, -33.03 -42.96, -45.47 APE12-dist-in 11.788 APE11-dist-in 12.049 APE10-dist-in 6.089 APE9-dist-in 3.401 E431A,R433A,E485A,K488A,R493A,R495A None None XRAY 2.08 0.204 0.231 A 316 298 6 0 0 0 [[244, 540]] 1.0 5e92 TKL_TGFBR2_HUMAN TKL 1.9e-77 266.3 2 266 265 396 397 398 400 402 277 290 294 376 378 377 379 446 428 423 422 421 420 419 418 417 326 TGF-beta receptor type-2
TYR EGFR EGFR_HUMAN 3VJNA P00533 697 1018 1210.0 ANP:2001 ATPlike Inactive DFGin 6.07 15.553 BLAminus -140.47, -172.56 66.89, 81.42 -96.27, 22.36 285.26, 99.8 -61.68, -24.37 in-out in 8.864 Saltbr-out 4.159 HRD-in -62.92, -47.49 66.12, 0.14 out-in-in SNCoii in-in ActLoopNT-in 2.902 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.98, 116.83 APE9-dihe-in -113.71, 140.82 APE8-dihe-in -56.67, 106.47 APE8-rot-na 28.1 APE67-dihe-in -67.09, -6.37 -61.28, -43.59 APE12-dist-na 11.779 APE11-dist-na 9.748 APE10-dist-na 10.983 APE9-dist-in 5.988 G719S,T790M None None XRAY 2.34 0.197 0.244 A 334 297 4 0 0 0 [[712, 970]] 1.0 3vjn TYR_EGFR_HUMAN TYR 7.9e-87 296.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8DSWA P00533 696 1017 1210.0 ANP:61104 ATPlike Inactive DFGin 5.926 15.858 BLAminus -139.88, -174.48 62.3, 80.03 -97.39, 21.12 300.26, 86.52 -53.52, -37.16 none-none none 999.0 Saltbr-none 999.0 HRD-in -81.01, -46.59 69.43, -1.39 none-in-none SNCnin in-none ActLoopNT-in 2.921 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 105.32 APE8-dihe-in -90.45, 95.73 APE8-rot-na 32.83 APE67-dihe-in -75.5, -1.32 -70.5, -35.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.219 None None None XRAY 2.39 0.197 0.246 A 335 301 12 0 0 9 [[712, 970]] 1.0 8dsw TYR_EGFR_HUMAN TYR 1.9e-85 292.3 3 259 257 854 855 856 858 860 745 -9999 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITXA P00533 697 1019 1210.0 ANP:2020 ATPlike Active DFGin 5.874 15.737 BLAminus -136.31, -171.94 65.34, 93.22 -111.54, 18.75 298.27, 92.75 -59.44, 2.06 in-in in 9.241 Saltbr-in 3.583 HRD-in -62.41, -44.72 61.37, 7.79 in-in-in SNCiii in-in ActLoopNT-in 2.642 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.73, 124.39 APE9-dihe-in -125.4, 144.12 APE8-dihe-in -79.64, 94.32 APE8-rot-na 30.37 APE67-dihe-in -65.37, -0.17 -61.69, -47.61 APE12-dist-na 11.888 APE11-dist-na 10.151 APE10-dist-na 11.134 APE9-dist-in 7.058 None None None XRAY 2.98 0.191 0.261 A 327 307 4 0 0 4 [[712, 970]] 1.0 2itx TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3VJOA P00533 696 1018 1210.0 ANP:2001 ATPlike Inactive DFGin 6.021 15.946 BLAminus -140.25, -165.5 56.51, 77.02 -90.26, 19.04 285.97, 94.98 -60.96, -7.67 in-out in 9.402 Saltbr-out 4.55 HRD-in -69.17, -43.62 63.06, 0.57 out-in-in SNCoii in-in ActLoopNT-in 2.921 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.49, 106.7 APE9-dihe-in -122.63, 146.56 APE8-dihe-in -79.91, 93.84 APE8-rot-na 34.61 APE67-dihe-in -67.26, -9.93 -59.74, -34.59 APE12-dist-na 12.246 APE11-dist-na 10.097 APE10-dist-na 10.762 APE9-dist-in 6.771 None None None XRAY 2.64 0.19 0.228 A 334 298 5 0 0 0 [[712, 970]] 1.0 3vjo TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITNA P00533 696 1019 1210.0 ANP:2021 ATPlike None DFGin 6.283 15.235 BLAminus -127.19, -173.38 63.95, 79.84 -96.65, 10.56 295.4, 91.5 -73.87, 28.38 in-in in 8.274 Saltbr-in 3.408 HRD-in -81.37, -44.82 70.79, -0.2 in-in-none SNCiin in-none ActLoopNT-in 2.843 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 98.73 APE8-dihe-in -79.18, 91.37 APE8-rot-na 30.4 APE67-dihe-in -69.96, -4.57 -72.15, -41.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.674 G719S None None XRAY 2.47 0.201 0.267 A 327 304 9 0 0 9 [[712, 970]] 1.0 2itn TYR_EGFR_HUMAN TYR 9.6e-87 296.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITVA P00533 696 1019 1210.0 ANP:2020 ATPlike None DFGin 6.216 15.481 BLAminus -132.41, -173.63 61.69, 81.35 -94.21, 13.19 293.51, 90.37 -58.84, 7.8 in-in in 8.584 Saltbr-in 3.462 HRD-in -75.87, -46.5 68.4, 1.6 in-in-none SNCiin in-none ActLoopNT-in 2.737 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.23 APE8-dihe-in -83.21, 92.63 APE8-rot-na 31.24 APE67-dihe-in -66.41, -6.91 -75.93, -39.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.569 L858R None None XRAY 2.47 0.197 0.242 A 327 303 9 0 0 9 [[712, 970]] 1.0 2itv TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2EB3A P00533 696 1018 1210.0 ANP:2001 ATPlike Inactive DFGin 4.666 14.869 BLAplus -146.31, -170.86 55.73, 31.55 -96.53, 44.19 45.64, 108.62 -72.56, -59.05 in-in in 8.594 Saltbr-in 3.443 HRD-out -53.85, 138.27 -123.62, 23.93 in-in-none SNCiin in-none ActLoopNT-in 2.585 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 154.55 APE8-dihe-in -88.38, 74.74 APE8-rot-na 41.16 APE67-dihe-in -67.41, -11.07 -62.2, -31.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.893 None None None XRAY 2.84 0.19 0.236 A 334 294 15 0 0 14 [[712, 970]] 1.0 2eb3 TYR_EGFR_HUMAN TYR 1.2e-86 296.3 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1LB P00533 702 1008 1210.0 ANP:1102 ATPlike Inactive DFGin 4.326 15.477 BLBplus -134.87, 177.11 52.28, 41.66 -92.52, 151.37 118.41, 82.73 79.24, 7.39 out-out out 13.751 Saltbr-out 14.766 HRD-in -69.63, -50.82 67.27, 3.74 out-out-out SNCooo out-out ActLoopNT-out 8.694 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -67.98 APE8-dihe-in -90.55, 79.54 APE8-rot-na 36.74 APE67-dihe-in -76.92, -3.19 -66.82, -38.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.382 T790M,V948R None None XRAY 2.8 0.203 0.237 B 327 292 15 0 0 15 [[712, 970]] 1.0 6p1l TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6WAKA P00533 702 1013 1210.0 ANP:1101 ATPlike Inactive DFGin 3.68 14.038 BLBplus -119.87, 174.58 64.54, 16.96 -69.25, 144.86 73.85, 86.13 77.2, -6.44 out-out out 14.19 Saltbr-out 14.87 HRD-in -68.06, -64.5 89.93, -15.8 out-out-out SNCooo out-out ActLoopNT-out 6.056 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -95.75, -0.13 APE9-dihe-in -104.56, 101.78 APE8-dihe-in -62.85, 69.07 APE8-rot-na 27.65 APE67-dihe-in -73.63, -8.28 -54.79, -35.95 APE12-dist-na 999.0 APE11-dist-na 15.624 APE10-dist-na 11.34 APE9-dist-in 7.772 T790M,V948R None None XRAY 2.4 0.219 0.23 A 328 297 10 0 0 10 [[712, 970]] 1.0 6wak TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6WAKD P00533 701 1014 1210.0 ANP:1101 ATPlike Inactive DFGin 3.881 14.667 BLBplus -128.56, 164.59 71.9, 35.94 -89.47, 146.64 77.53, 95.38 87.93, -24.37 out-out out 13.753 Saltbr-out 11.845 HRD-in -75.5, -62.2 82.94, 0.35 out-out-out SNCooo out-out ActLoopNT-out 6.735 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.69 APE8-dihe-in -82.11, 67.25 APE8-rot-na 35.47 APE67-dihe-in -67.78, -4.44 -51.76, -45.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.046 T790M,V948R None None XRAY 2.4 0.219 0.23 D 328 297 17 0 0 14 [[712, 970]] 1.0 6wak TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8FV3A P00533 701 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 3.96 13.397 BLBplus -132.16, 169.96 65.72, 32.0 -78.17, 140.3 56.84, 82.43 67.0, 6.27 out-out out 13.544 Saltbr-out 14.732 HRD-in -69.71, -62.71 86.1, -12.85 out-out-none SNCoon out-none ActLoopNT-out 6.542 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 27.23 APE9-dihe-in -63.25, 122.03 APE8-dihe-in -75.98, 67.82 APE8-rot-na 29.66 APE67-dihe-in -76.37, -3.74 -56.38, -36.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.726 APE9-dist-in 7.987 T790M,V948R None None XRAY 2.1 0.191 0.226 A 328 299 14 0 0 12 [[712, 970]] 1.0 8fv3 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8FV4C P00533 702 1013 1210.0 ANP:1102 ATPlike Inactive DFGin 4.082 13.558 BLBplus -127.73, 168.23 73.07, 11.78 -61.24, 145.82 61.45, 98.91 81.41, -31.2 out-out out 13.742 Saltbr-out 16.115 HRD-in -67.13, -63.64 88.26, -13.01 out-out-out SNCooo out-out ActLoopNT-out 6.584 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -45.21, -49.43 APE9-dihe-in -74.91, 126.99 APE8-dihe-in -76.17, 58.7 APE8-rot-na 28.97 APE67-dihe-in -74.88, -4.9 -52.62, -40.92 APE12-dist-na 999.0 APE11-dist-na 16.262 APE10-dist-na 12.232 APE9-dist-out 8.1 T790M,V948R None None XRAY 2.2 0.204 0.261 C 328 296 11 0 0 11 [[712, 970]] 1.0 8fv4 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO3B P00533 702 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 3.657 14.934 BLBplus -134.55, 162.66 68.08, 49.36 -93.73, 164.43 101.15, 105.54 56.1, 2.84 out-out out 13.767 Saltbr-out 13.971 HRD-in -68.15, -46.1 73.95, -11.19 out-out-out SNCooo out-out ActLoopNT-out 6.842 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 106.24 APE8-dihe-in -74.12, 71.61 APE8-rot-na 27.49 APE67-dihe-in -65.2, -1.6 -53.66, -41.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.13 T790M,V948R None None XRAY 2.49 0.231 0.269 B 328 291 18 0 0 13 [[712, 970]] 1.0 8to3 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO4B P00533 702 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 4.321 13.838 BLBplus -145.22, 172.21 45.08, 44.37 -91.4, 153.78 67.05, 82.38 64.94, 7.17 out-out out 14.011 Saltbr-out 13.48 HRD-in -63.39, -70.27 96.97, -15.43 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.51 APE8-dihe-in -77.84, 67.96 APE8-rot-na 10.85 APE67-dihe-in -65.93, -24.75 -51.27, -47.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.537 T790M,V948R None None XRAY 2.99 0.176 0.231 B 328 290 18 0 0 14 [[712, 970]] 1.0 8to4 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4ZSED P00533 701 1015 1210.0 ANP:4001 ATPlike Inactive DFGin 4.481 13.699 BLBplus -139.61, 164.7 66.53, 26.19 -71.23, 138.48 53.66, 91.47 74.43, 7.23 out-out out 13.877 Saltbr-out 13.686 HRD-in -70.41, -53.51 80.03, -13.83 out-out-none SNCoon out-none ActLoopNT-out 6.522 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.0 APE8-dihe-in -83.67, 68.18 APE8-rot-na 28.71 APE67-dihe-in -64.05, -23.47 -60.9, -39.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.989 T790M,V948R None None XRAY 1.97 0.191 0.213 D 331 297 14 0 0 12 [[712, 970]] 1.0 4zse TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5D41B P00533 701 1014 1210.0 ANP:2001 ATPlike Inactive DFGin 3.946 14.283 BLBplus -122.59, 173.39 56.77, 40.3 -84.43, 150.38 61.52, 86.97 79.88, -36.14 out-out out 13.666 Saltbr-out 11.144 HRD-in -72.27, -56.38 80.95, -10.72 out-out-out SNCooo out-out ActLoopNT-out 6.673 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -30.97 APE9-dihe-in -100.3, 124.18 APE8-dihe-in -72.86, 61.7 APE8-rot-na 30.04 APE67-dihe-in -79.76, 0.67 -51.2, -39.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.501 APE9-dist-out 8.352 T790M,V948R None None XRAY 2.31 0.175 0.207 B 331 302 12 0 0 12 [[712, 970]] 1.0 5d41 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5X2AD P00533 701 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 4.567 13.491 BLBplus -132.47, 164.02 73.22, 18.47 -66.23, 142.03 48.39, 91.71 77.4, 1.26 out-out out 13.992 Saltbr-out 14.35 HRD-in -72.94, -56.49 82.37, -10.91 out-out-out SNCooo out-out ActLoopNT-out 6.463 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 3.06 APE9-dihe-in -69.62, 129.82 APE8-dihe-in -83.4, 65.28 APE8-rot-na 22.72 APE67-dihe-in -72.49, -3.02 -53.67, -40.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.897 APE9-dist-out 8.235 T790M,V948R None None XRAY 1.85 0.176 0.219 D 331 297 13 0 0 10 [[712, 970]] 1.0 5x2a TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXKB P00533 700 1007 1210.0 ANP:1101 ATPlike Inactive DFGin 4.788 14.304 BLBplus -133.99, 169.66 58.32, 39.23 -93.88, 160.42 49.41, 87.38 74.89, 999.0 out-out out 13.49 Saltbr-out 12.394 HRD-in -66.37, -58.14 81.2, -5.32 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.52 APE8-dihe-in -80.54, 72.01 APE8-rot-na 30.24 APE67-dihe-in -73.85, -4.26 -53.45, -45.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.541 T790M,V948R None None XRAY 3.1 0.223 0.261 B 331 290 18 0 0 18 [[712, 970]] 1.0 7jxk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXMC P00533 702 1006 1210.0 ANP:1101 ATPlike Inactive DFGin 4.283 13.994 BLBplus -133.09, 168.24 59.36, 33.1 -80.78, 143.72 58.15, 87.09 66.36, 74.02 out-out out 13.963 Saltbr-out 13.118 HRD-in -67.9, -61.75 83.53, -6.82 out-out-none SNCoon out-none ActLoopNT-out 9.008 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.47 APE8-dihe-in -77.6, 66.96 APE8-rot-na 35.92 APE67-dihe-in -75.2, -5.27 -47.14, -42.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.517 T790M,V948R None None XRAY 2.192 0.228 0.271 C 331 285 20 0 0 15 [[712, 970]] 1.0 7jxm TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CNOB P00533 698 1015 1210.0 ANP:61001 ATPlike Inactive DFGin 3.889 14.151 BLBplus -128.77, 161.65 68.19, 38.17 -78.09, 143.32 56.13, 92.23 54.89, 36.11 out-out out 13.877 Saltbr-out 12.607 HRD-in -79.53, -48.18 74.57, -9.86 out-out-out SNCooo out-out ActLoopNT-out 8.188 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 114.62 APE9-dihe-in -83.89, 124.6 APE8-dihe-in -81.17, 61.86 APE8-rot-na 30.73 APE67-dihe-in -73.98, -7.26 -47.13, -40.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.092 APE9-dist-out 8.401 V948R None None XRAY 1.55 0.176 0.203 B 330 302 16 0 0 12 [[712, 970]] 1.0 5cno TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CNNA P00533 699 1014 1210.0 ANP:61101 ATPlike Inactive DFGin 3.97 14.17 BLBplus -125.09, 165.12 65.79, 30.65 -73.26, 142.49 57.23, 92.2 61.04, 28.88 out-out out 14.419 Saltbr-out 11.397 HRD-in -77.1, -52.71 74.61, -9.55 out-out-none SNCoon out-none ActLoopNT-out 8.169 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 61.56 APE9-dihe-in -85.48, 136.67 APE8-dihe-in -75.32, 67.13 APE8-rot-na 28.89 APE67-dihe-in -79.02, -2.66 -49.07, -38.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.997 APE9-dist-in 7.994 I706Q None None XRAY 1.9 0.183 0.211 A 350 300 16 0 0 13 [[712, 970]] 1.0 5cnn TYR_EGFR_HUMAN TYR 1.3e-87 299.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1DB P00533 702 1013 1210.0 ANP:1101,NQ1:1102 ATPlike,Type3 Inactive DFGin 4.737 14.03 BLBplus -133.29, 171.5 64.7, 17.77 -68.3, 145.06 52.12, 92.58 81.65, -14.38 out-out out 13.79 Saltbr-out 14.416 HRD-in -75.11, -58.04 81.02, -12.96 out-out-out SNCooo out-out ActLoopNT-out 6.39 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -53.71 APE8-dihe-in -78.39, 61.97 APE8-rot-na 34.06 APE67-dihe-in -73.46, -6.67 -54.96, -43.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.356 None None None XRAY 2.4 0.195 0.213 B 327 300 12 0 0 12 [[712, 970]] 1.0 6p1d TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1LA P00533 701 1007 1210.0 ANP:1102,9LL:1103 ATPlike,Type3 Inactive DFGin 5.09 14.609 BLBplus -137.99, 174.26 51.86, 38.49 -97.68, 160.33 56.12, 79.32 80.95, 13.49 out-out out 13.09 Saltbr-out 11.075 HRD-in -66.81, -53.87 69.64, 3.15 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.91 APE8-dihe-in -92.34, 76.37 APE8-rot-na 35.99 APE67-dihe-in -76.25, -4.78 -68.05, -35.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.361 T790M,V948R None None XRAY 2.8 0.203 0.237 A 327 288 19 0 0 17 [[712, 970]] 1.0 6p1l TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1LC P00533 702 1005 1210.0 ANP:1102,9LL:1103 ATPlike,Type3 Inactive DFGin 4.947 14.346 BLBplus -138.12, 175.57 52.19, 39.44 -97.35, 162.11 56.76, 79.57 81.63, 13.51 out-out out 13.069 Saltbr-out 12.69 HRD-in -65.46, -53.47 68.76, 3.35 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -21.1 APE8-dihe-in -91.14, 76.85 APE8-rot-na 36.16 APE67-dihe-in -74.42, -4.16 -69.53, -34.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.035 T790M,V948R None None XRAY 2.8 0.203 0.237 C 327 280 24 0 0 17 [[712, 970]] 1.0 6p1l TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1LD P00533 702 1015 1210.0 ANP:1102,9LL:1103 ATPlike,Type3 Inactive DFGin 5.193 14.634 BLBplus -136.45, 175.46 51.75, 39.49 -96.95, 158.96 56.24, 81.53 81.72, 11.0 out-out out 13.155 Saltbr-out 10.982 HRD-in -66.43, -53.42 65.79, 5.44 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.86 APE8-dihe-in -92.75, 77.55 APE8-rot-na 35.81 APE67-dihe-in -75.19, -4.23 -67.58, -35.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.094 T790M,V948R None None XRAY 2.8 0.203 0.237 D 327 296 17 0 0 17 [[712, 970]] 1.0 6p1l TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P8QA P00533 699 1019 1210.0 ANP:2001,O57:2002 ATPlike,Type3 Inactive DFGin 5.291 14.467 BLBplus -136.39, 166.39 65.62, 19.67 -68.64, 141.86 47.45, 96.29 88.91, -15.41 out-out out 13.793 Saltbr-out 13.394 HRD-in -77.48, -60.3 86.7, -15.68 out-out-none SNCoon out-none ActLoopNT-out 6.927 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 121.69 APE8-dihe-in -82.28, 70.48 APE8-rot-na 31.78 APE67-dihe-in -69.54, -10.7 -59.7, -40.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.523 T790M,V948R None None XRAY 1.9 0.169 0.195 A 327 309 12 0 0 12 [[712, 970]] 1.0 6p8q TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6XL4D P00533 700 1013 1210.0 ANP:1102,NQ1:1103 ATPlike,Type3 Inactive DFGin 4.89 14.247 BLBplus -133.2, 175.82 65.76, 18.85 -77.15, 145.6 52.8, 92.59 74.56, -2.19 out-out out 13.624 Saltbr-out 15.83 HRD-in -71.69, -57.79 76.59, -4.88 out-out-none SNCoon out-none ActLoopNT-out 6.478 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.17 APE8-dihe-in -78.79, 71.74 APE8-rot-na 31.74 APE67-dihe-in -74.38, -1.99 -55.71, -41.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.77 T790M,V948R None None XRAY 2.06 0.216 0.252 D 328 300 14 0 0 11 [[712, 970]] 1.0 6xl4 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO4C P00533 702 1013 1210.0 ANP:1102,IXR:1103 ATPlike,Type3 Inactive DFGin 5.324 14.703 BLBplus -141.27, 171.12 64.77, 53.38 -109.59, 167.64 42.74, 100.72 59.4, 999.0 out-out out 13.294 Saltbr-out 12.35 HRD-in -63.29, -59.94 84.01, 4.45 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.05 APE8-dihe-in -90.09, 61.93 APE8-rot-na 21.85 APE67-dihe-in -81.47, -6.07 -53.96, -24.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.836 T790M,V948R None None XRAY 2.99 0.176 0.231 C 328 289 18 0 0 18 [[712, 970]] 1.0 8to4 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO4D P00533 702 1005 1210.0 ANP:1102,IXR:1103 ATPlike,Type3 Inactive DFGin 4.551 14.188 BLBplus -127.27, 157.13 78.08, 44.22 -85.23, -172.29 38.08, 100.01 106.69, 999.0 out-out out 13.656 Saltbr-out 10.825 HRD-in -72.87, -44.75 69.45, -7.84 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 105.73 APE8-dihe-in -81.92, 60.79 APE8-rot-na 34.7 APE67-dihe-in -66.67, -11.33 -39.66, -48.35 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.66 T790M,V948R None None XRAY 2.99 0.176 0.231 D 328 283 20 0 0 18 [[712, 970]] 1.0 8to4 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5D41A P00533 698 1014 1210.0 ANP:1102,57N:1103 ATPlike,Type3 Inactive DFGin 4.968 14.448 BLBplus -130.27, 169.23 61.95, 37.88 -93.29, 173.71 50.74, 86.35 79.65, -10.55 out-out out 12.815 Saltbr-out 11.374 HRD-in -77.25, -55.76 78.51, -14.31 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 155.57 APE8-dihe-in -80.12, 74.82 APE8-rot-na 31.53 APE67-dihe-in -75.45, -3.11 -51.46, -43.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8 T790M,V948R None None XRAY 2.31 0.175 0.207 A 331 300 17 0 0 17 [[712, 970]] 1.0 5d41 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6DUKA P00533 701 1006 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.416 14.801 BLBplus -133.89, 165.03 66.94, 37.08 -93.36, 166.29 58.42, 86.37 91.91, 6.11 out-out out 13.918 Saltbr-out 14.179 HRD-in -76.73, -64.87 85.37, -18.97 out-out-out SNCooo out-out ActLoopNT-out 7.438 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.39, -10.84 APE9-dihe-in -125.5, 116.79 APE8-dihe-in -80.16, 76.04 APE8-rot-na 31.69 APE67-dihe-in -76.14, -1.34 -58.18, -44.83 APE12-dist-na 17.364 APE11-dist-na 15.202 APE10-dist-na 11.776 APE9-dist-in 7.311 T790M,V948R None None XRAY 2.2 0.191 0.223 A 331 306 0 0 0 0 [[712, 970]] 1.0 6duk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6DUKB P00533 699 1007 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.681 14.65 BLBplus -136.44, 165.42 61.83, 36.22 -89.54, 161.73 53.44, 89.67 90.48, 19.39 out-out out 13.812 Saltbr-out 14.733 HRD-in -68.48, -61.78 82.94, -15.18 out-out-none SNCoon out-none ActLoopNT-out 7.292 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.53 APE8-dihe-in -76.17, 63.91 APE8-rot-na 26.99 APE67-dihe-in -79.83, -2.27 -51.77, -41.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.922 T790M,V948R None None XRAY 2.2 0.191 0.223 B 331 296 13 0 0 13 [[712, 970]] 1.0 6duk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6DUKC P00533 699 1007 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.661 14.391 BLBplus -137.36, 170.05 61.14, 32.95 -87.42, 165.36 52.89, 84.68 86.51, 15.0 out-out out 13.749 Saltbr-out 12.387 HRD-in -66.04, -61.2 80.35, -9.27 out-out-none SNCoon out-none ActLoopNT-out 8.286 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 116.92 APE8-dihe-in -77.64, 67.39 APE8-rot-na 32.93 APE67-dihe-in -71.69, -8.16 -55.72, -42.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.823 T790M,V948R None None XRAY 2.2 0.191 0.223 C 331 295 14 0 0 14 [[712, 970]] 1.0 6duk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6DUKD P00533 701 1007 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.605 14.634 BLBplus -137.83, 165.45 65.63, 29.61 -82.3, 167.28 56.12, 84.13 94.16, 13.47 out-out out 14.053 Saltbr-out 14.886 HRD-in -74.03, -57.71 81.46, -18.53 out-out-out SNCooo out-out ActLoopNT-out 7.321 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -76.03, 11.31 APE9-dihe-in -134.89, 121.24 APE8-dihe-in -86.59, 77.19 APE8-rot-na 34.21 APE67-dihe-in -72.84, -7.51 -59.65, -43.13 APE12-dist-na 17.747 APE11-dist-na 15.555 APE10-dist-na 11.903 APE9-dist-in 7.539 T790M,V948R None None XRAY 2.2 0.191 0.223 D 331 307 0 0 0 0 [[712, 970]] 1.0 6duk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6DUKE P00533 698 1007 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.706 14.387 BLBplus -132.31, 167.27 63.11, 42.82 -102.17, 159.55 52.62, 85.09 88.84, 16.78 out-out out 13.768 Saltbr-out 14.361 HRD-in -70.33, -59.21 85.76, -23.74 out-out-none SNCoon out-none ActLoopNT-out 7.686 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 1.83 APE9-dihe-in -127.74, 112.92 APE8-dihe-in -68.38, 64.27 APE8-rot-na 21.48 APE67-dihe-in -73.72, -8.33 -52.7, -41.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.291 APE9-dist-in 7.941 T790M,V948R None None XRAY 2.2 0.191 0.223 E 331 298 12 0 0 12 [[712, 970]] 1.0 6duk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6DUKF P00533 701 1009 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.653 14.612 BLBplus -133.82, 164.75 63.96, 32.85 -83.32, 163.7 53.83, 93.49 88.31, 19.42 out-out out 14.108 Saltbr-out 15.144 HRD-in -67.38, -62.37 88.35, -19.9 out-out-none SNCoon out-none ActLoopNT-out 7.319 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.72 APE8-dihe-in -80.72, 70.63 APE8-rot-na 32.98 APE67-dihe-in -75.6, -2.87 -62.49, -36.24 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.841 T790M,V948R None None XRAY 2.2 0.191 0.223 F 331 298 11 0 0 11 [[712, 970]] 1.0 6duk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXKD P00533 700 1007 1210.0 ANP:1101,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.861 14.45 BLBplus -134.29, 170.65 60.11, 37.92 -95.07, 160.21 48.8, 86.41 74.63, 26.88 out-out out 13.457 Saltbr-out 11.763 HRD-in -66.46, -59.56 80.54, -6.1 out-out-none SNCoon out-none ActLoopNT-out 8.903 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.41 APE8-dihe-in -81.29, 71.57 APE8-rot-na 30.4 APE67-dihe-in -73.66, -4.05 -53.54, -44.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.472 T790M,V948R None None XRAY 3.1 0.223 0.261 D 331 294 14 0 0 14 [[712, 970]] 1.0 7jxk TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXMD P00533 700 1007 1210.0 ANP:1101,9LL:1103 ATPlike,Type3 Inactive DFGin 4.952 14.337 BLBplus -135.28, 170.25 61.86, 31.57 -85.27, 155.14 53.77, 85.22 78.23, 19.31 out-out out 13.049 Saltbr-out 11.894 HRD-in -66.52, -63.02 84.71, -6.37 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.04 APE8-dihe-in -80.42, 66.88 APE8-rot-na 32.97 APE67-dihe-in -76.05, -3.45 -51.47, -42.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.762 T790M,V948R None None XRAY 2.192 0.228 0.271 D 331 291 17 0 0 17 [[712, 970]] 1.0 7jxm TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXPA P00533 700 1007 1210.0 ANP:1101,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.747 14.617 BLBplus -136.18, 166.76 64.66, 34.04 -92.53, 168.9 56.02, 85.41 85.63, 11.86 out-out out 13.988 Saltbr-out 14.307 HRD-in -74.54, -64.28 89.28, -17.63 out-out-out SNCooo out-out ActLoopNT-out 7.509 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -97.63, -15.8 APE9-dihe-in -113.05, 126.54 APE8-dihe-in -83.29, 68.9 APE8-rot-na 33.94 APE67-dihe-in -74.36, -3.96 -52.3, -47.62 APE12-dist-na 17.096 APE11-dist-na 14.956 APE10-dist-na 11.693 APE9-dist-in 7.406 T790M,V948R None None XRAY 2.16 0.214 0.247 A 331 308 0 0 0 0 [[712, 970]] 1.0 7jxp TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXPB P00533 700 1007 1210.0 ANP:1101,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.671 14.511 BLBplus -135.21, 165.17 64.35, 37.85 -90.15, 169.17 53.82, 91.67 84.59, 7.68 out-out out 13.756 Saltbr-out 13.888 HRD-in -70.65, -63.17 87.36, -17.28 out-out-out SNCooo out-out ActLoopNT-out 7.592 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -97.44, -17.16 APE9-dihe-in -126.66, 129.43 APE8-dihe-in -78.52, 67.74 APE8-rot-na 34.72 APE67-dihe-in -76.32, -3.64 -51.52, -45.13 APE12-dist-na 17.438 APE11-dist-na 15.214 APE10-dist-na 12.275 APE9-dist-in 7.617 T790M,V948R None None XRAY 2.16 0.214 0.247 B 331 308 0 0 0 0 [[712, 970]] 1.0 7jxp TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXPD P00533 700 1007 1210.0 ANP:1101,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.766 14.661 BLBplus -135.69, 167.35 65.6, 33.96 -89.97, 168.72 55.6, 87.2 84.96, 9.82 out-out out 13.526 Saltbr-out 11.283 HRD-in -71.06, -65.03 87.13, -14.24 out-out-none SNCoon out-none ActLoopNT-out 8.004 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.01 APE8-dihe-in -77.89, 69.26 APE8-rot-na 33.29 APE67-dihe-in -74.9, -2.69 -52.27, -42.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.744 T790M,V948R None None XRAY 2.16 0.214 0.247 D 331 294 14 0 0 14 [[712, 970]] 1.0 7jxp TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXPF P00533 700 1007 1210.0 ANP:1101,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.974 14.702 BLBplus -136.82, 166.82 61.14, 36.57 -93.57, 171.83 53.4, 92.66 83.03, -0.51 out-out out 13.674 Saltbr-out 11.57 HRD-in -71.01, -63.71 87.17, -13.68 out-out-none SNCoon out-none ActLoopNT-out 9.118 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.33 APE8-dihe-in -78.62, 69.48 APE8-rot-na 32.72 APE67-dihe-in -72.69, -4.28 -52.16, -45.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.621 T790M,V948R None None XRAY 2.16 0.214 0.247 F 331 294 14 0 0 14 [[712, 970]] 1.0 7jxp TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXQB P00533 701 1007 1210.0 ANP:1102,VNS:1103 ATPlike,Type3 Inactive DFGin 4.915 14.438 BLBplus -136.8, 171.78 58.87, 35.86 -91.33, 162.29 51.51, 87.21 80.67, 16.0 out-out out 13.335 Saltbr-out 12.698 HRD-in -67.21, -58.71 77.88, -12.51 out-out-none SNCoon out-none ActLoopNT-out 8.896 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -177.71 APE9-dihe-in -105.47, 135.84 APE8-dihe-in -83.2, 67.78 APE8-rot-na 33.37 APE67-dihe-in -74.22, -7.65 -49.73, -41.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.734 APE9-dist-in 7.645 T790M,V948R None None XRAY 1.83 0.185 0.218 B 331 297 10 0 0 10 [[712, 970]] 1.0 7jxq TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXQD P00533 700 1007 1210.0 ANP:1102,VNS:1103 ATPlike,Type3 Inactive DFGin 4.844 14.328 BLBplus -136.14, 172.56 58.98, 36.18 -92.84, 162.13 51.55, 88.05 79.36, 17.26 out-out out 13.42 Saltbr-out 11.89 HRD-in -65.12, -58.0 78.92, -12.53 out-out-none SNCoon out-none ActLoopNT-out 8.94 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.09 APE8-dihe-in -80.19, 68.24 APE8-rot-na 33.29 APE67-dihe-in -74.77, -5.19 -50.69, -44.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.579 T790M,V948R None None XRAY 1.83 0.185 0.218 D 331 298 10 0 0 10 [[712, 970]] 1.0 7jxq TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7LTXA P00533 700 1007 1210.0 ANP:1101,YFA:1103 ATPlike,Type3 Inactive DFGin 5.248 14.564 BLBplus -135.35, 163.04 64.03, 33.94 -82.37, 179.4 48.16, 87.26 -162.42, -162.89 out-out out 13.182 Saltbr-out 10.599 HRD-in -67.02, -61.48 82.46, -5.8 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.93 APE8-dihe-in -80.94, 68.72 APE8-rot-na 31.43 APE67-dihe-in -70.18, -9.53 -51.9, -44.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.02 T790M,V948R None None XRAY 2.3 0.187 0.216 A 331 292 16 0 0 16 [[712, 970]] 1.0 7ltx TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7LTXB P00533 700 1007 1210.0 ANP:1101,YFA:1103 ATPlike,Type3 Inactive DFGin 5.197 14.495 BLBplus -136.17, 169.66 62.42, 34.77 -78.22, 170.05 42.44, 90.17 -152.16, -165.64 out-out out 13.123 Saltbr-out 10.226 HRD-in -65.63, -61.11 82.51, -6.05 out-out-none SNCoon out-none ActLoopNT-out 9.239 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.13 APE8-dihe-in -82.01, 66.41 APE8-rot-na 31.46 APE67-dihe-in -73.58, -7.26 -49.71, -42.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.829 T790M,V948R None None XRAY 2.3 0.187 0.216 B 331 293 15 0 0 15 [[712, 970]] 1.0 7ltx TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7LTXC P00533 700 1007 1210.0 ANP:1101,YFA:1103 ATPlike,Type3 Inactive DFGin 5.123 14.511 BLBplus -136.55, 165.71 63.6, 32.17 -87.45, 156.27 46.73, 94.27 148.1, 156.05 out-out out 13.071 Saltbr-out 10.076 HRD-in -65.09, -59.89 81.29, -6.26 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.8 APE8-dihe-in -79.63, 67.92 APE8-rot-na 31.3 APE67-dihe-in -72.94, -5.81 -52.93, -44.7 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.864 T790M,V948R None None XRAY 2.3 0.187 0.216 C 331 292 16 0 0 16 [[712, 970]] 1.0 7ltx TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7LTXD P00533 700 1007 1210.0 ANP:1101,YFA:1103 ATPlike,Type3 Inactive DFGin 5.346 14.443 BLBplus -137.08, 165.99 63.56, 34.05 -81.77, 167.16 44.82, 94.68 -177.57, 165.83 out-out out 12.986 Saltbr-out 10.34 HRD-in -68.33, -62.57 83.39, -4.99 out-out-none SNCoon out-none ActLoopNT-out 9.494 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.9 APE8-dihe-in -80.86, 67.56 APE8-rot-na 30.12 APE67-dihe-in -73.23, -5.97 -50.49, -42.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.917 T790M,V948R None None XRAY 2.3 0.187 0.216 D 331 293 15 0 0 15 [[712, 970]] 1.0 7ltx TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8GB4A P00533 700 1007 1210.0 ANP:1102,YW5:1103 ATPlike,Type3 Inactive DFGin 4.738 14.778 BLBplus -140.96, 174.92 57.37, 44.23 -99.53, 158.98 50.67, 86.24 74.62, 16.37 out-out out 13.355 Saltbr-out 11.698 HRD-in -69.91, -59.18 79.33, -9.52 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.01 APE8-dihe-in -76.27, 67.14 APE8-rot-na 30.24 APE67-dihe-in -75.65, -5.48 -58.37, -41.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.058 T790M,V948R None None XRAY 2.59 0.23 0.254 A 331 292 16 0 0 16 [[712, 970]] 1.0 8gb4 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8GB4B P00533 700 1007 1210.0 ANP:1102,YW5:1103 ATPlike,Type3 Inactive DFGin 4.858 14.681 BLBplus -140.61, 174.15 57.09, 43.59 -100.33, 162.57 51.99, 86.76 77.41, 18.84 out-out out 13.39 Saltbr-out 10.531 HRD-in -69.24, -58.17 79.24, -10.08 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.16 APE8-rot-na 30.06 APE67-dihe-in -75.09, -5.85 -58.81, -39.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,V948R None None XRAY 2.59 0.23 0.254 B 331 290 18 0 0 18 [[712, 970]] 1.0 8gb4 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8GB4C P00533 700 1012 1210.0 ANP:1102,YW5:1103 ATPlike,Type3 Inactive DFGin 4.732 14.602 BLBplus -141.16, 174.43 57.44, 44.8 -99.46, 158.79 49.11, 85.48 74.36, 22.53 out-out out 13.185 Saltbr-out 11.537 HRD-in -70.07, -59.0 77.64, -8.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.65 APE8-dihe-in -76.99, 66.94 APE8-rot-na 30.24 APE67-dihe-in -75.42, -5.6 -59.05, -41.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.014 T790M,V948R None None XRAY 2.59 0.23 0.254 C 331 297 16 0 0 16 [[712, 970]] 1.0 8gb4 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8GB4D P00533 700 1007 1210.0 ANP:1102,YW5:1103 ATPlike,Type3 Inactive DFGin 4.686 14.698 BLBplus -141.21, 175.0 57.29, 43.49 -99.79, 159.92 51.61, 87.18 76.57, 22.15 out-out out 13.561 Saltbr-out 10.91 HRD-in -69.19, -58.43 79.07, -10.45 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 65.97 APE8-rot-na 30.21 APE67-dihe-in -74.96, -5.48 -59.31, -40.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,V948R None None XRAY 2.59 0.23 0.254 D 331 291 17 0 0 17 [[712, 970]] 1.0 8gb4 TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7K1IA P00533 700 1007 1210.0 ANP:1102,VNS:1103 ATPlike,Type3 Inactive DFGin 4.837 14.412 BLBplus -124.92, 173.52 55.34, 38.4 -93.27, 168.4 51.69, 86.03 70.99, 11.24 out-out out 13.596 Saltbr-out 12.212 HRD-in -68.02, -55.76 76.66, -7.58 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.86 APE8-dihe-in -84.0, 73.03 APE8-rot-na 29.2 APE67-dihe-in -72.27, -9.54 -58.41, -42.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.42 L858R,V948R None None XRAY 3.202 0.266 0.311 A 331 288 20 0 0 17 [[712, 970]] 1.0 7k1i TYR_EGFR_HUMAN TYR 8.5e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1DC P00533 702 1006 1210.0 NQ1:1101,ANP:1102 Type3,ATPlike Inactive DFGin 5.383 14.459 BLBplus -142.0, 171.97 66.8, 29.01 -86.08, 152.7 44.82, 92.23 73.36, -11.9 out-out out 13.614 Saltbr-out 13.736 HRD-in -69.23, -60.69 76.65, -2.9 out-out-none SNCoon out-none ActLoopNT-out 6.785 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 96.45 APE8-dihe-in -76.51, 79.09 APE8-rot-na 31.04 APE67-dihe-in -75.49, -1.74 -58.74, -40.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.258 None None None XRAY 2.4 0.195 0.213 C 327 292 13 0 0 13 [[712, 970]] 1.0 6p1d TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1DD P00533 701 1008 1210.0 NQ1:1101,ANP:1102 Type3,ATPlike Inactive DFGin 4.796 14.102 BLBplus -132.01, 171.13 65.01, 17.93 -68.87, 143.86 51.94, 90.04 79.55, -15.22 out-out out 13.622 Saltbr-out 13.734 HRD-in -75.21, -58.43 80.83, -11.58 out-out-none SNCoon out-none ActLoopNT-out 6.633 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.5 APE8-dihe-in -78.23, 70.43 APE8-rot-na 33.16 APE67-dihe-in -74.16, -5.23 -50.48, -45.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.251 None None None XRAY 2.4 0.195 0.213 D 327 295 13 0 0 13 [[712, 970]] 1.0 6p1d TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXQA P00533 700 1007 1210.0 VNS:1102,ANP:1103 Type3,ATPlike Inactive DFGin 4.86 14.542 BLBplus -136.59, 171.99 58.78, 36.07 -93.08, 163.3 53.5, 85.99 81.0, 16.2 out-out out 13.6 Saltbr-out 11.402 HRD-in -66.89, -59.97 80.26, -12.87 out-out-out SNCooo out-out ActLoopNT-out 8.834 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 0.37 APE9-dihe-in -62.95, 136.95 APE8-dihe-in -80.94, 64.03 APE8-rot-na 32.82 APE67-dihe-in -75.31, -4.79 -52.17, -43.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.411 APE9-dist-out 8.21 T790M,V948R None None XRAY 1.83 0.185 0.218 A 331 296 12 0 0 12 [[712, 970]] 1.0 7jxq TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXQC P00533 700 1007 1210.0 VNS:1102,ANP:1103 Type3,ATPlike Inactive DFGin 4.785 14.453 BLBplus -135.56, 173.47 59.34, 36.33 -94.04, 161.61 52.57, 85.94 80.36, 16.26 out-out out 13.527 Saltbr-out 12.033 HRD-in -65.88, -57.49 78.82, -12.32 out-out-none SNCoon out-none ActLoopNT-out 8.819 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.15 APE8-dihe-in -80.46, 67.52 APE8-rot-na 31.26 APE67-dihe-in -73.66, -6.11 -51.25, -43.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.434 T790M,V948R None None XRAY 1.83 0.185 0.218 C 331 298 10 0 0 10 [[712, 970]] 1.0 7jxq TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1DA P00533 700 1021 1210.0 ANP:1101 ATPlike Inactive DFGin 5.301 16.437 BLBtrans -129.26, 172.58 65.52, 23.29 -64.33, 142.93 151.16, 79.23 78.73, -15.31 out-out out 13.52 Saltbr-out 12.421 HRD-in -76.98, -57.73 83.77, -12.82 out-out-none SNCoon out-none ActLoopNT-out 7.141 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 149.92 APE9-dihe-in -115.71, 137.77 APE8-dihe-in -79.58, 71.21 APE8-rot-na 32.94 APE67-dihe-in -73.74, -5.13 -51.22, -45.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.184 APE9-dist-in 7.677 None None None XRAY 2.4 0.195 0.213 A 327 309 13 0 0 13 [[712, 970]] 1.0 6p1d TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6WAKB P00533 701 1020 1210.0 ANP:1101 ATPlike Inactive DFGin 5.177 16.231 BLBtrans -117.23, 173.55 69.28, 15.65 -59.01, 135.6 148.98, 94.52 90.59, -20.79 out-out out 13.949 Saltbr-out 13.543 HRD-in -74.15, -58.44 85.37, -10.97 out-out-none SNCoon out-none ActLoopNT-out 6.481 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -3.86 APE9-dihe-in -108.7, 124.16 APE8-dihe-in -81.26, 64.66 APE8-rot-na 31.83 APE67-dihe-in -71.85, -2.7 -48.1, -51.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.366 APE9-dist-in 7.826 T790M,V948R None None XRAY 2.4 0.219 0.23 B 328 316 4 0 0 4 [[712, 970]] 1.0 6wak TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6WXNB P00533 701 1021 1210.0 ANP:1101 ATPlike Inactive DFGin 5.283 16.295 BLBtrans -123.51, 174.07 66.96, 19.19 -61.23, 137.15 158.07, 75.44 91.96, -18.66 out-out out 13.565 Saltbr-out 13.523 HRD-in -75.09, -55.39 80.46, -8.33 out-out-none SNCoon out-none ActLoopNT-out 6.48 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -21.86 APE9-dihe-in -115.99, 110.82 APE8-dihe-in -78.55, 77.75 APE8-rot-na 31.2 APE67-dihe-in -73.85, -5.28 -56.42, -42.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.825 APE9-dist-in 7.844 T790M,V948R None None XRAY 1.76 0.209 0.235 B 328 303 11 0 0 11 [[712, 970]] 1.0 6wxn TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8FV3B P00533 701 1021 1210.0 ANP:1102 ATPlike Inactive DFGin 5.439 16.496 BLBtrans -118.64, 177.37 63.4, 20.55 -58.75, 145.81 159.38, 77.34 77.7, -11.94 out-out out 13.907 Saltbr-out 12.609 HRD-in -79.27, -57.12 85.07, -16.18 out-out-none SNCoon out-none ActLoopNT-out 6.551 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -85.47 APE9-dihe-in -94.5, 111.51 APE8-dihe-in -78.45, 79.51 APE8-rot-na 26.67 APE67-dihe-in -72.96, -7.53 -57.83, -45.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.158 APE9-dist-in 7.609 T790M,V948R None None XRAY 2.1 0.191 0.226 B 328 307 12 0 0 12 [[712, 970]] 1.0 8fv3 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8FV3D P00533 701 1008 1210.0 ANP:1102 ATPlike Inactive DFGin 5.123 16.069 BLBtrans -118.91, 178.66 63.22, 20.1 -58.76, 136.59 151.59, 72.8 86.53, -14.56 out-out out 13.636 Saltbr-out 11.878 HRD-in -77.73, -54.76 83.51, -15.49 out-out-none SNCoon out-none ActLoopNT-out 6.686 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -35.35 APE9-dihe-in -75.26, 139.37 APE8-dihe-in -77.41, 75.08 APE8-rot-na 30.35 APE67-dihe-in -77.52, -1.37 -56.44, -41.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.989 APE9-dist-in 7.856 T790M,V948R None None XRAY 2.1 0.191 0.226 D 328 295 13 0 0 12 [[712, 970]] 1.0 8fv3 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8FV4A P00533 701 1013 1210.0 ANP:1102 ATPlike Inactive DFGin 5.115 16.083 BLBtrans -131.04, 178.71 63.39, 21.89 -65.77, 133.12 153.56, 67.25 81.77, -5.74 out-out out 13.965 Saltbr-out 14.366 HRD-in -75.29, -65.35 93.54, -10.41 out-out-out SNCooo out-out ActLoopNT-out 6.614 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.22 APE8-dihe-in -79.99, 70.44 APE8-rot-na 34.65 APE67-dihe-in -69.8, 5.09 -60.12, -39.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.027 T790M,V948R None None XRAY 2.2 0.204 0.261 A 328 298 15 0 0 13 [[712, 970]] 1.0 8fv4 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO3C P00533 702 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 5.753 16.533 BLBtrans -133.38, -174.65 59.98, 24.74 -65.74, 136.64 157.32, 80.88 79.44, -13.7 out-out out 13.655 Saltbr-out 13.531 HRD-in -66.43, -56.05 80.37, -11.56 out-out-out SNCooo out-out ActLoopNT-out 6.373 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.97 APE8-dihe-in -84.11, 59.51 APE8-rot-na 29.31 APE67-dihe-in -74.18, -0.3 -51.78, -42.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.174 T790M,V948R None None XRAY 2.49 0.231 0.269 C 328 295 16 0 0 13 [[712, 970]] 1.0 8to3 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO3D P00533 702 1008 1210.0 ANP:1102 ATPlike Inactive DFGin 6.266 16.712 BLBtrans -127.69, 172.31 68.6, 30.15 -69.25, 140.14 165.75, 69.84 67.25, -4.22 out-out out 14.386 Saltbr-out 13.199 HRD-in -68.61, -53.44 82.24, -15.94 out-out-out SNCooo out-out ActLoopNT-out 6.552 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 120.24 APE8-dihe-in -79.84, 75.73 APE8-rot-na 31.27 APE67-dihe-in -78.58, -0.75 -60.94, -39.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.144 T790M,V948R None None XRAY 2.49 0.231 0.269 D 328 293 14 0 0 13 [[712, 970]] 1.0 8to3 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO4A P00533 701 1021 1210.0 ANP:1102 ATPlike Inactive DFGin 5.629 16.547 BLBtrans -124.14, -173.94 46.92, 31.67 -57.81, 155.21 158.64, 67.25 48.87, 11.58 out-out out 13.96 Saltbr-out 13.561 HRD-in -72.61, -58.43 93.96, -37.09 out-out-none SNCoon out-none ActLoopNT-out 6.932 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 82.65 APE8-dihe-in -66.65, 104.87 APE8-rot-na 26.84 APE67-dihe-in -69.56, -10.93 -75.01, -49.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.724 T790M,V948R None None XRAY 2.99 0.176 0.231 A 328 300 16 0 0 13 [[712, 970]] 1.0 8to4 TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4ZSEA P00533 699 1007 1210.0 ANP:1101 ATPlike Inactive DFGin 5.335 16.18 BLBtrans -132.89, 171.35 59.18, 30.95 -64.3, 136.47 153.66, 69.99 84.54, -7.18 out-out out 13.41 Saltbr-out 12.542 HRD-in -69.44, -53.13 80.36, -12.32 out-out-none SNCoon out-none ActLoopNT-out 6.5 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 151.84 APE9-dihe-in -73.75, 154.61 APE8-dihe-in -84.04, 78.01 APE8-rot-na 31.44 APE67-dihe-in -73.82, -9.83 -53.67, -42.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.754 APE9-dist-in 7.631 T790M,V948R None None XRAY 1.97 0.191 0.213 A 331 297 12 0 0 12 [[712, 970]] 1.0 4zse TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4ZSEB P00533 698 1022 1210.0 ANP:2001 ATPlike Inactive DFGin 5.443 16.534 BLBtrans -132.18, 168.84 69.74, 21.23 -63.33, 134.02 158.02, 77.95 88.87, -12.59 out-out out 13.594 Saltbr-out 12.729 HRD-in -70.54, -56.98 84.69, -9.62 out-out-none SNCoon out-none ActLoopNT-out 6.279 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -169.23 APE9-dihe-in -113.21, 138.46 APE8-dihe-in -83.6, 77.16 APE8-rot-na 29.29 APE67-dihe-in -64.08, -26.4 -59.09, -39.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.095 APE9-dist-in 7.664 T790M,V948R None None XRAY 1.97 0.191 0.213 B 331 313 12 0 0 12 [[712, 970]] 1.0 4zse TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4ZSEC P00533 700 1013 1210.0 ANP:3001 ATPlike Inactive DFGin 5.527 16.551 BLBtrans -132.06, 169.7 72.1, 15.79 -57.63, 131.91 161.52, 79.23 90.56, -14.81 out-out out 13.464 Saltbr-out 12.84 HRD-in -70.03, -52.52 81.38, -14.98 out-out-none SNCoon out-none ActLoopNT-out 6.218 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.83 APE8-dihe-in -83.98, 70.07 APE8-rot-na 31.43 APE67-dihe-in -69.54, -11.42 -60.89, -38.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.916 T790M,V948R None None XRAY 1.97 0.191 0.213 C 331 301 13 0 0 13 [[712, 970]] 1.0 4zse TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXMA P00533 700 1007 1210.0 ANP:1101 ATPlike Inactive DFGin 4.958 16.172 BLBtrans -132.35, 172.29 62.1, 35.15 -75.21, 146.26 142.71, 77.54 74.06, -11.26 out-out out 13.894 Saltbr-out 13.34 HRD-in -71.64, -59.02 81.62, -5.92 out-out-none SNCoon out-none ActLoopNT-out 8.072 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 131.88 APE8-dihe-in -79.6, 70.11 APE8-rot-na 34.33 APE67-dihe-in -76.06, -4.61 -47.57, -45.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.53 T790M,V948R None None XRAY 2.192 0.228 0.271 A 331 287 18 0 0 14 [[712, 970]] 1.0 7jxm TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2GS7A P00533 703 1012 1210.0 ANP:60301 ATPlike Inactive DFGin 5.373 16.634 BLBtrans -99.51, 171.1 60.81, 33.31 -69.51, 142.46 163.35, 73.66 92.75, -41.51 out-out out 14.089 Saltbr-out 13.075 HRD-in -69.91, -45.27 73.69, -18.97 out-out-out SNCooo out-out ActLoopNT-out 6.362 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 134.47 APE9-dihe-in -142.48, 136.32 APE8-dihe-in -67.69, 63.71 APE8-rot-na 37.05 APE67-dihe-in -69.28, 11.68 -49.57, -49.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.012 APE9-dist-out 8.2 V948R None None XRAY 2.6 0.258 0.298 A 330 281 4 0 0 4 [[712, 970]] 1.0 2gs7 TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2GS7B P00533 701 1016 1210.0 ANP:60302 ATPlike Inactive DFGin 5.284 16.349 BLBtrans -104.25, 165.26 71.85, 26.96 -61.96, 139.7 163.92, 72.26 85.01, -32.88 out-out out 13.995 Saltbr-out 14.309 HRD-in -67.25, -42.1 68.95, -3.07 out-out-none SNCoon out-none ActLoopNT-out 6.473 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 151.84 APE9-dihe-in -148.05, 134.8 APE8-dihe-in -62.95, 72.83 APE8-rot-na 33.79 APE67-dihe-in -67.93, 1.22 -55.72, -45.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.13 APE9-dist-in 7.902 V948R None None XRAY 2.6 0.258 0.298 B 330 288 3 0 0 3 [[712, 970]] 1.0 2gs7 TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3GT8A P00533 700 1014 1210.0 ANP:60002 ATPlike Inactive DFGin 4.993 16.39 BLBtrans -126.87, 160.91 79.29, 15.25 -62.33, 143.15 149.45, 88.24 77.42, 3.92 out-out out 14.088 Saltbr-out 14.957 HRD-in -72.04, -61.33 88.51, -0.69 out-out-none SNCoon out-none ActLoopNT-out 6.56 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 19.46 APE8-rot-na 342.23 APE67-dihe-in -68.79, -19.52 -40.63, -50.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V948R None None XRAY 2.955 0.219 0.275 A 330 300 15 0 0 15 [[712, 970]] 1.0 3gt8 TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3GT8B P00533 701 1007 1210.0 ANP:60001 ATPlike Inactive DFGin 5.247 16.102 BLBtrans -113.7, -174.86 52.25, 31.77 -67.43, 143.58 157.41, 75.54 60.22, 2.12 out-out out 13.355 Saltbr-out 13.716 HRD-in -65.21, -59.58 85.13, -27.25 out-out-none SNCoon out-none ActLoopNT-out 6.384 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 3.18 APE8-rot-na 352.22 APE67-dihe-in -64.44, -9.93 -42.76, -50.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V948R None None XRAY 2.955 0.219 0.275 B 330 292 15 0 0 15 [[712, 970]] 1.0 3gt8 TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3GT8C P00533 699 1007 1210.0 ANP:60003 ATPlike Inactive DFGin 4.731 16.042 BLBtrans -111.03, -172.93 50.46, 27.13 -68.53, 136.25 146.08, 72.89 59.13, 17.74 out-out out 14.315 Saltbr-out 13.283 HRD-in -57.94, -53.03 83.1, -30.64 out-out-none SNCoon out-none ActLoopNT-out 6.516 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 131.04 APE8-dihe-in -73.71, 55.48 APE8-rot-na 345.44 APE67-dihe-in -72.77, 4.68 -41.49, -48.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.982 V948R None None XRAY 2.955 0.219 0.275 C 330 296 13 0 0 13 [[712, 970]] 1.0 3gt8 TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3GT8D P00533 701 1010 1210.0 ANP:60004 ATPlike Inactive DFGin 5.236 16.347 BLBtrans -129.98, 167.43 62.52, 32.14 -70.14, 140.82 152.86, 71.47 77.5, -20.57 out-out out 14.059 Saltbr-out 13.514 HRD-in -61.66, -53.51 87.8, -16.84 out-out-none SNCoon out-none ActLoopNT-out 6.797 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 30.46 APE8-rot-na 344.36 APE67-dihe-in -63.75, 2.23 -59.31, -42.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V948R None None XRAY 2.955 0.219 0.275 D 330 295 15 0 0 15 [[712, 970]] 1.0 3gt8 TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CNOA P00533 700 1015 1210.0 ANP:61001 ATPlike Inactive DFGin 5.504 16.161 BLBtrans -118.04, 171.2 68.22, 21.52 -56.79, 132.54 171.14, 68.18 99.53, -19.86 out-out out 13.718 Saltbr-out 12.944 HRD-in -82.44, -48.26 77.49, -9.43 out-out-out SNCooo out-out ActLoopNT-out 6.341 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 122.24 APE9-dihe-in -77.97, 140.5 APE8-dihe-in -80.47, 64.47 APE8-rot-na 27.48 APE67-dihe-in -78.06, -5.87 -50.51, -36.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.588 APE9-dist-out 8.271 V948R None None XRAY 1.55 0.176 0.203 A 330 300 16 0 0 11 [[712, 970]] 1.0 5cno TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CNNB P00533 700 1014 1210.0 ANP:61101 ATPlike Inactive DFGin 5.571 16.39 BLBtrans -117.7, 174.34 67.16, 24.17 -60.91, 135.45 168.23, 72.49 97.23, -21.68 out-out out 13.788 Saltbr-out 12.759 HRD-in -80.25, -51.08 77.81, -11.48 out-out-out SNCooo out-out ActLoopNT-out 6.374 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -75.45 APE9-dihe-in -63.67, 125.67 APE8-dihe-in -78.86, 65.92 APE8-rot-na 30.44 APE67-dihe-in -73.57, -5.24 -51.98, -40.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.086 APE9-dist-out 8.279 I706Q None None XRAY 1.9 0.183 0.211 B 350 304 11 0 0 11 [[712, 970]] 1.0 5cnn TYR_EGFR_HUMAN TYR 1.3e-87 299.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5X2AB P00533 700 1022 1210.0 7XO:1105,ANP:1106 Type1,ATPlike Inactive DFGin 5.521 16.379 BLBtrans -118.08, 178.13 68.28, 22.21 -63.57, 132.1 161.37, 67.84 99.95, -15.3 out-out out 13.892 Saltbr-out 13.505 HRD-in -67.87, -49.57 81.65, -13.01 out-out-out SNCooo out-out ActLoopNT-out 6.364 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -63.35, -22.61 APE9-dihe-in -95.03, 108.56 APE8-dihe-in -83.98, 72.85 APE8-rot-na 21.28 APE67-dihe-in -71.39, -9.89 -59.75, -39.3 APE12-dist-na 15.726 APE11-dist-na 13.245 APE10-dist-na 9.274 APE9-dist-in 7.568 T790M,V948R None None XRAY 1.85 0.176 0.219 B 331 322 0 0 0 0 [[712, 970]] 1.0 5x2a TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5X2AA P00533 700 1011 1210.0 7XO:1107,ANP:1108 Type1,Allosteric Inactive DFGin 5.565 16.303 BLBtrans -120.52, 179.71 70.51, 14.21 -61.87, 136.6 165.52, 70.66 90.66, -18.93 out-out out 13.778 Saltbr-out 13.104 HRD-in -79.48, -46.8 73.07, -8.08 out-out-none SNCoon out-none ActLoopNT-out 6.728 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 152.51 APE8-dihe-in -84.48, 76.35 APE8-rot-na 26.1 APE67-dihe-in -71.21, -12.48 -60.14, -38.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.762 T790M,V948R None None XRAY 1.85 0.176 0.219 A 331 297 13 0 0 13 [[712, 970]] 1.0 5x2a TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EPHA2 EPHA2_HUMAN 1MQBA P29317 605 887 976.0 ANP:1000 ATPlike Inactive DFGin 5.712 14.924 BLAminus -127.53, -172.03 57.53, 74.63 -109.94, 122.74 306.64, 100.38 176.53, 104.78 in-out in 8.465 Saltbr-out 5.675 HRD-in -62.1, -45.48 77.42, -17.66 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -37.06 APE9-dihe-in -88.14, 119.95 APE8-dihe-in -73.81, 144.85 APE8-rot-na 33.04 APE67-dihe-in -82.72, 0.0 -54.3, -43.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.553 APE9-dist-in 5.598 None None None XRAY 2.3 0.237 0.288 A 333 263 20 0 0 17 [[613, 873]] 1.0 1mqb TYR_EPHA2_HUMAN TYR 7.4e-108 365.7 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 1MQBB P29317 602 883 976.0 ANP:1001 ATPlike None DFGin 5.691 14.889 BLAminus -139.65, -173.77 51.28, 81.33 -92.67, 10.65 292.99, 95.58 -41.77, -44.65 in-in in 8.273 Saltbr-in 2.64 HRD-in -72.65, -50.06 79.19, -16.04 in-in-none SNCiin in-none ActLoopNT-in 2.992 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -50.3 APE9-dihe-in -134.32, 148.66 APE8-dihe-in -83.15, 83.63 APE8-rot-na 31.61 APE67-dihe-in -80.07, -2.61 -53.54, -47.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.328 APE9-dist-in 6.633 None None None XRAY 2.3 0.237 0.288 B 333 265 17 0 0 13 [[613, 873]] 1.0 1mqb TYR_EPHA2_HUMAN TYR 7.4e-108 365.7 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 5I9WA P29317 605 895 976.0 ANP:1001 ATPlike Inactive DFGin 6.244 15.281 BLBminus -125.95, -162.36 67.3, 57.63 -98.89, 156.85 294.37, 103.89 164.47, 175.48 in-in in 8.347 Saltbr-in 2.764 HRD-in -75.49, -48.49 78.15, -15.84 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.31 APE8-dihe-in -84.75, 145.17 APE8-rot-na 35.12 APE67-dihe-in -78.8, -3.01 -55.81, -43.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.342 None None None XRAY 1.359 0.17 0.18 A 306 267 24 0 0 18 [[613, 873]] 1.0 5i9w TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA3 EPHA3_HUMAN 2QOCA P29320 613 906 983.0 ANP:949 ATPlike Inactive DFGin 4.995 15.445 BLAminus -141.69, -171.73 58.63, 84.29 -97.26, 21.84 297.12, 103.61 -61.69, -31.71 in-out in 9.495 Saltbr-out 6.048 HRD-in -71.05, -48.03 74.01, -8.74 out-in-none SNCoin in-none ActLoopNT-in 3.023 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 135.66 APE9-dihe-in -81.0, 137.87 APE8-dihe-in -77.44, 99.9 APE8-rot-na 34.81 APE67-dihe-in -63.09, -22.76 -54.0, -44.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.214 APE9-dist-in 5.514 None None None XRAY 1.25 0.17 0.186 A 344 283 11 0 0 11 [[621, 880]] 1.0 2qoc TYR_EPHA3_HUMAN TYR 8.4e-111 375.4 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 3FXXA P29320 606 904 983.0 ANP:992 ATPlike Inactive DFGin 4.9 15.171 BLAminus -132.57, -176.13 56.24, 78.37 -91.43, 22.66 298.54, 96.01 -59.15, -30.35 in-out in 9.376 Saltbr-out 4.254 HRD-in -72.67, -46.91 76.32, -4.64 out-in-in SNCoii in-in ActLoopNT-in 2.804 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.39, 147.18 APE9-dihe-in -116.01, 151.61 APE8-dihe-in -77.44, 77.25 APE8-rot-na 30.85 APE67-dihe-in -60.25, -20.23 -50.19, -49.06 APE12-dist-na 999.0 APE11-dist-na 8.999 APE10-dist-na 10.183 APE9-dist-in 6.238 A608T None None XRAY 1.7 0.168 0.194 A 371 288 9 0 0 9 [[621, 880]] 1.0 3fxx TYR_EPHA3_HUMAN TYR 1.1e-110 375.1 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2QO7A P29320 595 904 983.0 ANP:1000 ATPlike Inactive DFGin 5.481 15.556 BLAminus -130.76, -168.32 68.6, 58.57 -92.37, 46.9 297.61, 96.94 -87.84, 999.0 in-out in 8.4 Saltbr-out 4.348 HRD-in -73.41, -45.48 73.79, -12.75 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 85.99 APE8-rot-na 29.77 APE67-dihe-in -61.7, -25.84 -53.26, -41.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None PTR701 PTR701 XRAY 1.605 0.186 0.224 A 373 279 20 0 0 20 [[621, 880]] 1.0 2qo7 TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2QO9A P29320 608 904 983.0 ANP:948 ATPlike Inactive DFGin 5.205 15.375 BLAminus -133.34, -177.89 59.05, 80.14 -92.65, 15.74 295.85, 100.25 -55.83, -40.55 in-out in 9.235 Saltbr-out 4.23 HRD-in -71.62, -45.86 73.18, -10.67 out-in-out SNCoio in-out ActLoopNT-in 2.997 ActLoopCT-out TYR APEdihe_noiai APEdist_aaai APE10-dihe-none 999.0, 105.46 APE9-dihe-out 41.85, 78.2 APE8-dihe-in -71.02, 94.17 APE8-rot-na 29.94 APE67-dihe-in -61.69, -23.23 -54.76, -43.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.168 APE9-dist-in 5.854 None None None XRAY 1.55 0.183 0.211 A 373 277 13 0 0 13 [[621, 880]] 1.0 2qo9 TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2QOQA P29320 595 906 983.0 ANP:948 ATPlike None DFGin 5.36 15.575 BLAminus -132.4, -170.9 64.35, 72.55 -105.5, 56.47 301.01, 91.74 -101.2, 999.0 in-in in 8.635 Saltbr-in 2.727 HRD-in -73.3, -48.21 73.66, -6.72 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 133.24 APE9-dihe-in -154.49, 111.52 APE8-dihe-in -76.14, 92.58 APE8-rot-na 29.51 APE67-dihe-in -62.32, -22.8 -60.77, -45.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.743 None PTR701 PTR701 XRAY 1.6 0.19 0.219 A 373 285 18 0 0 18 [[621, 880]] 1.0 2qoq TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR ERBB3 ERBB3_HUMAN 3KEXA P21860 698 994 1342.0 ANP:60001 ATPlike Pseudo DFGin 5.66 12.692 BLBplus -136.97, 172.9 58.22, 40.12 -96.04, 155.03 48.2, 92.31 69.55, -19.76 out-na out 15.235 Saltbr-na 999.0 HRD-in -90.16, -54.52 74.78, -7.72 na-out-out SNCaoo out-out ActLoopNT-out 6.728 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.57 APE8-dihe-out -99.2, 24.49 APE8-rot-na 333.43 APE67-dihe-in -74.24, 11.38 -68.56, -18.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.774 None None None XRAY 2.797 0.243 0.283 A 325 292 5 0 0 5 [[709, 967]] 1.0 3kex TYR_ERBB3_HUMAN TYR 6e-80 274.2 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 3KEXB P21860 698 988 1342.0 ANP:60002 ATPlike Pseudo DFGin 5.652 12.673 BLBplus -137.46, 172.26 58.51, 39.18 -94.14, 155.27 47.87, 93.32 68.94, -19.33 out-na out 15.232 Saltbr-na 999.0 HRD-in -90.89, -54.23 74.6, -7.22 na-out-out SNCaoo out-out ActLoopNT-out 6.727 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 145.38 APE8-dihe-out -51.8, -10.63 APE8-rot-na 330.98 APE67-dihe-in -73.43, 11.3 -67.12, -27.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.215 None None None XRAY 2.797 0.243 0.283 B 325 283 7 0 0 7 [[709, 967]] 1.0 3kex TYR_ERBB3_HUMAN TYR 6e-80 274.2 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIWA P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.665 12.919 BLBplus -124.68, 170.7 61.91, 32.93 -86.72, 138.2 53.99, 90.7 80.0, -6.46 out-na out 15.12 Saltbr-na 999.0 HRD-in -76.0, -53.69 67.87, 2.11 na-out-none SNCaon out-none ActLoopNT-out 6.632 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -2.58 APE8-rot-na 28.66 APE67-dihe-in -88.2, -5.19 -70.28, -23.24 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 3.1 0.233 0.287 A 326 269 12 0 0 12 [[709, 967]] 1.0 4riw TYR_ERBB3_HUMAN TYR 6.1e-80 274.2 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIWC P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.618 13.032 BLBplus -125.06, 170.64 62.1, 33.09 -86.97, 138.33 54.47, 90.5 80.01, -6.38 out-na out 15.49 Saltbr-na 999.0 HRD-in -75.9, -53.21 67.39, 0.69 na-out-out SNCaoo out-out ActLoopNT-out 6.393 ActLoopCT-out TYR APEdihe_oioai APEdist_aaao APE10-dihe-out -113.39, 20.05 APE9-dihe-in -68.39, 127.6 APE8-dihe-out -63.99, -4.42 APE8-rot-na 333.17 APE67-dihe-in -86.76, -6.22 -71.15, -22.24 APE12-dist-na 21.544 APE11-dist-na 20.419 APE10-dist-na 15.408 APE9-dist-out 10.083 None None None XRAY 3.1 0.233 0.287 C 326 275 6 0 0 0 [[709, 967]] 1.0 4riw TYR_ERBB3_HUMAN TYR 6.1e-80 274.2 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 3LMGA P21860 699 978 1342.0 ANP:60301 ATPlike Pseudo DFGin 5.728 12.964 BLBplus -117.83, 170.87 63.58, 24.7 -69.26, 132.03 43.93, 98.75 70.87, 7.13 out-na out 15.578 Saltbr-na 999.0 HRD-in -64.67, -52.37 74.61, 1.05 na-out-out SNCaoo out-out ActLoopNT-out 6.623 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 104.53 APE8-dihe-out -45.34, -17.97 APE8-rot-na 330.0 APE67-dihe-in -71.66, -7.63 -57.32, -31.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.464 None None None XRAY 2.8 0.255 0.285 A 344 268 12 0 0 9 [[709, 967]] 1.0 3lmg TYR_ERBB3_HUMAN TYR 7.3e-80 274.0 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 3LMGB P21860 699 978 1342.0 ANP:60301 ATPlike Pseudo DFGin 5.789 12.844 BLBplus -113.43, 165.54 66.13, 22.95 -73.3, 147.22 48.63, 94.29 81.01, -18.45 out-na out 15.381 Saltbr-na 999.0 HRD-in -77.74, -52.9 74.69, -13.1 na-out-none SNCaon out-none ActLoopNT-out 6.805 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -22.84 APE8-rot-na 330.0 APE67-dihe-in -67.55, -12.53 -55.83, -37.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.255 0.285 B 344 268 12 0 0 9 [[709, 967]] 1.0 3lmg TYR_ERBB3_HUMAN TYR 7.3e-80 274.0 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIYA P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.753 12.868 BLBplus -123.9, 168.71 62.98, 31.45 -82.39, 142.59 52.35, 86.17 78.8, -6.78 out-na out 15.044 Saltbr-na 999.0 HRD-in -75.26, -54.75 69.16, 2.85 na-out-none SNCaon out-none ActLoopNT-out 6.45 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -9.22 APE8-rot-na 31.12 APE67-dihe-in -85.56, -1.17 -67.69, -25.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 E928G None None XRAY 2.981 0.221 0.267 A 326 269 12 0 0 12 [[709, 967]] 1.0 4riy TYR_ERBB3_HUMAN TYR 1.3e-79 273.1 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIYC P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.577 13.185 BLBplus -124.39, 168.66 63.11, 31.61 -82.48, 141.95 52.91, 86.81 78.36, -7.08 out-na out 15.605 Saltbr-na 999.0 HRD-in -74.67, -54.96 68.56, 2.02 na-out-out SNCaoo out-out ActLoopNT-out 6.525 ActLoopCT-out TYR APEdihe_oioai APEdist_aaao APE10-dihe-out -99.97, 8.97 APE9-dihe-in -62.65, 132.93 APE8-dihe-out -66.25, -9.79 APE8-rot-na 341.07 APE67-dihe-in -85.25, -1.58 -67.21, -25.34 APE12-dist-na 22.285 APE11-dist-na 20.535 APE10-dist-na 15.613 APE9-dist-out 10.163 E928G None None XRAY 2.981 0.221 0.267 C 326 275 6 0 0 0 [[709, 967]] 1.0 4riy TYR_ERBB3_HUMAN TYR 1.3e-79 273.1 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIXA P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.534 12.788 BLBplus -125.2, 170.11 60.89, 28.84 -82.14, 140.77 56.51, 90.87 77.72, -6.25 out-na out 15.04 Saltbr-na 999.0 HRD-in -77.1, -53.12 66.52, 0.72 na-out-none SNCaon out-none ActLoopNT-out 6.513 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -5.5 APE8-rot-na 30.9 APE67-dihe-in -82.84, -10.3 -67.07, -25.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q809R None None XRAY 3.1 0.21 0.258 A 326 269 12 0 0 12 [[709, 967]] 1.0 4rix TYR_ERBB3_HUMAN TYR 9.7e-80 273.5 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIXC P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.557 13.116 BLBplus -126.64, 170.72 61.2, 28.92 -82.69, 140.73 56.76, 91.32 77.44, -6.2 out-na out 15.473 Saltbr-na 999.0 HRD-in -76.48, -52.61 66.58, -0.13 na-out-out SNCaoo out-out ActLoopNT-out 6.372 ActLoopCT-out TYR APEdihe_oioai APEdist_aaao APE10-dihe-out -112.15, 5.58 APE9-dihe-in -58.87, 135.06 APE8-dihe-out -71.85, -6.39 APE8-rot-na 348.17 APE67-dihe-in -82.4, -10.58 -67.81, -25.66 APE12-dist-na 21.658 APE11-dist-na 20.612 APE10-dist-na 15.605 APE9-dist-out 9.969 Q809R None None XRAY 3.1 0.21 0.258 C 326 275 6 0 0 0 [[709, 967]] 1.0 4rix TYR_ERBB3_HUMAN TYR 9.7e-80 273.5 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR FGFR2 FGFR2_HUMAN 5UGLA P21802 468 764 821.0 ANP:802 ATPlike Inactive DFGin 6.732 14.464 BLAminus -137.83, -175.53 60.75, 66.42 -85.03, 17.04 287.79, 92.86 -66.15, -23.38 in-in in 7.669 Saltbr-in 2.761 HRD-in -76.2, -48.26 75.23, -6.81 in-in-out SNCiio in-out ActLoopNT-in 2.865 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.99, 26.82 APE9-dihe-in -107.7, 135.68 APE8-dihe-in -52.5, 118.32 APE8-rot-na 330.79 APE67-dihe-in -70.92, -8.04 -59.23, -38.34 APE12-dist-na 14.887 APE11-dist-na 10.816 APE10-dist-na 7.642 APE9-dist-in 5.103 D650V None None XRAY 1.861 0.221 0.258 A 324 285 12 0 0 0 [[481, 759]] 1.0 5ugl TYR_FGFR2_HUMAN TYR 4.3e-104 353.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5UGLB P21802 467 764 821.0 ANP:802 ATPlike Inactive DFGin 6.738 14.48 BLAminus -137.57, -172.18 55.78, 69.64 -87.75, 15.81 286.63, 92.96 -64.54, -22.36 in-in in 7.653 Saltbr-in 2.718 HRD-in -74.83, -48.38 75.49, -7.57 in-in-out SNCiio in-out ActLoopNT-in 2.868 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.07, 25.73 APE9-dihe-in -107.84, 135.51 APE8-dihe-in -51.06, 118.2 APE8-rot-na 329.13 APE67-dihe-in -71.28, -8.69 -57.7, -39.45 APE12-dist-na 999.0 APE11-dist-na 10.831 APE10-dist-na 7.669 APE9-dist-in 5.084 D650V None None XRAY 1.861 0.221 0.258 B 324 271 27 0 0 11 [[481, 759]] 1.0 5ugl TYR_FGFR2_HUMAN TYR 4.3e-104 353.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR HCK HCK_HUMAN 1AD5A P08631 79 526 526.0 ANP:60001 ATPlike Inactive DFGin 6.878 13.556 BLAminus -111.54, 157.75 55.86, 95.53 -99.86, -56.89 321.06, 144.41 -91.88, 132.97 out-out out 13.592 Saltbr-out 14.452 HRD-out -92.59, 96.14 -56.64, -30.38 out-out-out SNCooo out-out ActLoopNT-out 11.414 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -107.24, 53.46 APE9-dihe-in -96.28, 143.43 APE8-dihe-out -62.47, 38.68 APE8-rot-na 35.25 APE67-dihe-in -59.4, -26.12 -40.35, -46.47 APE12-dist-na 11.659 APE11-dist-na 16.604 APE10-dist-na 16.133 APE9-dist-out 10.414 None PTR522 PTR522 XRAY 2.6 0.239 0.307 A 438 438 0 0 0 0 [[262, 513]] 1.0 1ad5 TYR_HCK_HUMAN TYR 1.4e-88 303.1 1 260 260 398 399 400 402 404 290 305 309 378 380 379 381 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 1AD5B P08631 79 526 526.0 ANP:60532 ATPlike Inactive DFGin 6.635 13.529 BLAminus -108.53, 152.83 57.68, 95.37 -100.87, -57.78 321.85, 133.69 -88.86, 132.45 out-out out 13.591 Saltbr-out 14.334 HRD-out -97.62, 96.0 -55.31, -32.54 out-out-out SNCooo out-out ActLoopNT-out 11.48 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.78, 54.95 APE9-dihe-in -97.18, 143.16 APE8-dihe-out -68.08, 36.88 APE8-rot-na 32.16 APE67-dihe-in -59.62, -27.02 -36.62, -45.49 APE12-dist-na 11.684 APE11-dist-na 16.585 APE10-dist-na 16.206 APE9-dist-out 10.534 None PTR522 PTR522 XRAY 2.6 0.239 0.307 B 438 438 0 0 0 0 [[262, 513]] 1.0 1ad5 TYR_HCK_HUMAN TYR 1.4e-88 303.1 1 260 260 398 399 400 402 404 290 305 309 378 380 379 381 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR IGF1R IGF1R_HUMAN 1JQHA P08069 984 1286 1367.0 ANP:301 ATPlike Inactive DFGin 5.69 16.569 None -66.7, 163.88 -59.45, 151.32 -140.18, 178.07 43.94, 89.38 -106.76, 173.06 in-out in 9.977 Saltbr-out 6.056 HRD-in -50.88, -56.96 74.77, -3.78 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -84.24, 106.81 APE9-dihe-in -58.88, 134.76 APE8-dihe-in -78.96, 121.64 APE8-rot-na 37.96 APE67-dihe-in -60.45, -7.73 -52.46, -43.95 APE12-dist-na 7.157 APE11-dist-na 11.3 APE10-dist-na 15.597 APE9-dist-in 5.8 E979G,Y980S None None XRAY 2.1 0.195 0.219 A 308 291 12 0 0 7 [[999, 1268]] 1.0 1jqh TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 1JQHB P08069 984 1286 1367.0 ANP:302 ATPlike Inactive DFGin 5.687 16.554 None -65.78, 164.4 -59.98, 151.89 -140.81, 178.2 43.68, 89.42 -109.69, -174.77 in-out in 9.988 Saltbr-out 6.019 HRD-in -51.69, -56.66 74.32, -2.97 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.6, 107.67 APE9-dihe-in -58.75, 135.36 APE8-dihe-in -79.54, 122.52 APE8-rot-na 37.69 APE67-dihe-in -59.25, -7.46 -52.18, -45.28 APE12-dist-na 6.817 APE11-dist-na 10.932 APE10-dist-na 15.216 APE9-dist-in 5.768 E979G,Y980S None None XRAY 2.1 0.195 0.219 B 308 287 16 0 0 7 [[999, 1268]] 1.0 1jqh TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 1JQHC P08069 984 1286 1367.0 ANP:303 ATPlike Inactive DFGin 5.698 16.558 None -65.47, 162.73 -58.75, 151.62 -140.8, 179.03 43.87, 88.98 -110.24, -177.72 in-out in 9.999 Saltbr-out 6.035 HRD-in -53.2, -57.0 74.59, -2.63 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.9, 107.89 APE9-dihe-in -58.88, 134.76 APE8-dihe-in -79.04, 122.75 APE8-rot-na 38.27 APE67-dihe-in -60.34, -8.42 -53.61, -43.61 APE12-dist-na 6.926 APE11-dist-na 10.986 APE10-dist-na 15.245 APE9-dist-in 5.774 E979G,Y980S None None XRAY 2.1 0.195 0.219 C 308 291 12 0 0 7 [[999, 1268]] 1.0 1jqh TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR INSR INSR_HUMAN 1IR3A P06213 1008 1310 1382.0 ANP:60300 ATPlike Inactive DFGin 6.128 14.366 BLAminus -133.72, -168.17 47.48, 85.02 -100.33, 24.62 303.32, 104.39 -58.78, -39.74 in-out in 8.923 Saltbr-out 4.393 HRD-in -68.06, -49.87 71.52, -7.17 out-in-in SNCoii in-in ActLoopNT-in 2.902 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.98, 116.19 APE9-dihe-in -117.81, 138.98 APE8-dihe-in -77.82, 71.42 APE8-rot-na 34.55 APE67-dihe-in -66.85, -13.55 -40.74, -47.32 APE12-dist-na 14.511 APE11-dist-na 10.427 APE10-dist-na 9.764 APE9-dist-in 6.771 C1008S,Y1011F PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 1.9 0.194 0.226 A 306 303 0 0 0 0 [[1023, 1292]] 1.0 1ir3 TYR_INSR_HUMAN TYR 1.4e-96 328.7 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR LCK LCK_HUMAN 1QPCA P06239 231 502 509.0 ANP:904 ATPlike Active DFGin 6.61 14.416 BLAminus -133.73, 179.02 58.4, 83.48 -97.79, 21.23 295.19, 99.8 -60.65, -35.99 in-in in 8.702 Saltbr-in 3.096 HRD-in -103.01, -49.32 74.3, -4.36 in-in-in SNCiii in-in ActLoopNT-in 2.921 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.97, 142.08 APE9-dihe-in -126.79, 156.19 APE8-dihe-in -63.13, 117.89 APE8-rot-na 333.56 APE67-dihe-in -65.85, -20.96 -57.94, -43.39 APE12-dist-na 14.856 APE11-dist-na 10.005 APE10-dist-na 12.788 APE9-dist-in 6.784 None PTR394 PTR394 XRAY 1.6 0.2 0.23 A 279 272 0 0 0 0 [[245, 496]] 1.0 1qpc TYR_LCK_HUMAN TYR 1.4e-94 322.2 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
TYR MERTK MERTK_HUMAN 2P0CA Q12866 575 861 999.0 ANP:1 ATPlike Inactive DFGin 5.924 13.136 BLBplus -137.27, 178.6 60.37, 23.32 -81.61, 167.49 49.71, 91.11 85.65, -47.4 out-none out 13.649 Saltbr-none 999.0 HRD-in -80.53, -55.62 75.56, -3.56 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 51.71 APE8-rot-na 32.28 APE67-dihe-in -80.87, -2.88 -33.63, -45.94 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.208 0.274 A 313 249 38 0 0 18 [[587, 856]] 1.0 2p0c TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 2P0CB Q12866 575 861 999.0 ANP:2 ATPlike Inactive DFGin 6.034 13.332 BLBplus -140.6, 176.88 63.43, 26.39 -92.68, 153.87 48.18, 81.79 87.34, -0.94 out-none out 13.973 Saltbr-none 999.0 HRD-in -83.37, -59.67 75.95, 2.32 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.74 APE8-rot-na 27.11 APE67-dihe-in -70.68, -3.16 -43.98, -45.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.208 0.274 B 313 248 39 0 0 18 [[587, 856]] 1.0 2p0c TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MST1R RON_HUMAN 3PLSA Q04912 1060 1357 1400.0 ANP:1358 ATPlike Inactive DFGin 6.296 13.436 BLBplus -158.57, 169.48 54.59, 28.32 -75.35, 163.89 46.83, 88.44 77.37, 8.52 out-out out 14.502 Saltbr-out 15.681 HRD-in -64.04, -56.3 78.09, -13.1 out-out-out SNCooo out-out ActLoopNT-out 7.396 ActLoopCT-out TYR APEdihe_oioai APEdist_aaao APE10-dihe-out -133.31, 27.58 APE9-dihe-in -79.04, 151.37 APE8-dihe-out -60.01, -26.4 APE8-rot-na 344.59 APE67-dihe-in -77.79, -6.02 -43.7, -39.07 APE12-dist-na 21.53 APE11-dist-na 22.492 APE10-dist-na 18.033 APE9-dist-out 10.623 M1254T None None XRAY 2.24 0.235 0.29 A 298 298 0 0 0 0 [[1082, 1343]] 1.0 3pls TYR_MST1R_HUMAN TYR 3.8e-88 301.1 4 260 257 1225 1226 1227 1229 1231 1114 1131 1135 1205 1207 1206 1208 1269 1257 1252 1251 1250 1249 1248 1247 1246 1162 Macrophage-stimulating protein receptor
TYR MST1R RON_HUMAN 8ZKDA Q04912 1060 1357 1400.0 ANP:1401 ATPlike Inactive DFGin 5.963 13.445 BLBplus -136.42, 163.89 75.82, 17.06 -71.65, 165.79 57.65, 82.07 74.72, 11.98 out-out out 14.72 Saltbr-out 14.955 HRD-in -65.95, -60.68 80.92, -14.74 out-out-out SNCooo out-out ActLoopNT-out 7.373 ActLoopCT-out TYR APEdihe_iooai APEdist_aaao APE10-dihe-in -84.37, 161.73 APE9-dihe-out -52.23, -44.7 APE8-dihe-out -56.31, -27.37 APE8-rot-na 334.62 APE67-dihe-in -83.51, -2.98 -41.89, -46.09 APE12-dist-na 22.059 APE11-dist-na 19.032 APE10-dist-na 14.222 APE9-dist-out 10.029 None None None XRAY 2.05 0.18 0.231 A 298 298 0 0 0 0 [[1082, 1343]] 1.0 8zkd TYR_MST1R_HUMAN TYR 3.8e-88 301.1 4 260 257 1225 1226 1227 1229 1231 1114 1131 1135 1205 1207 1206 1208 1269 1257 1252 1251 1250 1249 1248 1247 1246 1162 Macrophage-stimulating protein receptor
TYR SRC SRC_HUMAN 2SRCA P12931 87 536 536.0 ANP:60001 ATPlike Inactive DFGin 5.923 13.597 BLBplus -121.59, 173.63 47.36, 36.7 -81.78, 143.05 40.4, 84.17 86.45, -40.21 out-out out 14.118 Saltbr-out 13.928 HRD-in -73.32, -58.33 81.61, -7.89 out-out-out SNCooo out-out ActLoopNT-out 7.541 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.49, -13.33 APE9-dihe-in -91.46, 129.38 APE8-dihe-in -79.29, 62.74 APE8-rot-na 33.55 APE67-dihe-in -68.18, -15.62 -55.52, -29.75 APE12-dist-na 17.379 APE11-dist-na 18.743 APE10-dist-na 13.455 APE9-dist-out 8.746 None PTR530 PTR530 XRAY 1.5 0.226 0.281 A 452 450 0 0 0 0 [[270, 521]] 1.0 2src TYR_SRC_HUMAN TYR 6.7e-94 320.2 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SYK KSYK_HUMAN 4FL1A P43405 363 635 635.0 ANP:701 ATPlike Active DFGin 6.669 15.063 BLAminus -122.6, -175.53 56.16, 78.38 -92.62, 24.67 287.04, 93.75 -57.67, -38.36 in-in in 8.059 Saltbr-in 2.683 HRD-in -76.27, -50.57 71.77, 3.28 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.55, 85.11 APE9-dihe-in -99.28, 138.37 APE8-dihe-in -79.64, 69.72 APE8-rot-na 29.68 APE67-dihe-in -60.65, -16.95 -44.16, -41.68 APE12-dist-na 13.816 APE11-dist-na 10.806 APE10-dist-na 10.412 APE9-dist-in 7.132 None None None XRAY 1.79 0.197 0.225 A 291 268 5 0 0 0 [[370, 628]] 1.0 4fl1 TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4FL3A P43405 9 635 635.0 ANP:701 ATPlike Inactive DFGin 5.271 12.411 BLBplus -116.27, 169.06 58.02, 22.77 -60.26, 128.95 39.87, 90.8 70.36, 3.28 out-out out 13.347 Saltbr-out 12.957 HRD-in -71.66, -54.51 80.39, -19.8 out-out-none SNCoon out-none ActLoopNT-out 7.03 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 2.25 APE8-rot-na 29.04 APE67-dihe-in -63.72, -20.72 -59.66, -31.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y348F,Y352F None None XRAY 1.9 0.18 0.208 A 635 538 13 0 0 13 [[370, 628]] 1.0 4fl3 TYR_SYK_HUMAN TYR 5.1e-89 304.2 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4FL2A P43405 9 635 635.0 ANP:702 ATPlike Inactive DFGin 5.428 12.328 BLBplus -115.2, 163.41 55.5, 31.26 -66.72, 128.2 35.56, 90.39 65.72, 13.6 out-out out 13.491 Saltbr-out 13.203 HRD-in -70.05, -49.77 75.03, -15.27 out-out-out SNCooo out-out ActLoopNT-out 7.194 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -115.16, 144.55 APE9-dihe-in -104.91, 94.8 APE8-dihe-out -50.62, -30.17 APE8-rot-na 333.32 APE67-dihe-in -61.99, -18.29 -62.08, -21.97 APE12-dist-na 15.556 APE11-dist-na 19.206 APE10-dist-na 15.736 APE9-dist-out 11.527 None None None XRAY 2.19 0.184 0.228 A 636 555 0 0 0 0 [[370, 628]] 1.0 4fl2 TYR_SYK_HUMAN TYR 5.1e-89 304.2 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR ZAP70 ZAP70_HUMAN 2OZOA P43403 2 606 619.0 ANP:60615 ATPlike Inactive DFGin 5.897 12.889 BLAplus -127.72, 179.11 41.99, 48.0 -92.67, 86.43 47.29, 92.46 138.54, -47.19 out-out out 14.182 Saltbr-out 12.481 HRD-in -87.29, -57.15 80.94, -19.73 out-out-out SNCooo out-out ActLoopNT-out 7.529 ActLoopCT-out TYR APEdihe_nnnao APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 93.52 APE8-rot-na 331.14 APE67-dihe-out -88.9, 16.07 -148.01, 51.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y315F,Y319F,D461N None None XRAY 2.6 0.26 0.29 A 613 538 14 0 0 14 [[338, 595]] 1.0 2ozo TYR_ZAP70_HUMAN TYR 8.5e-89 303.4 6 259 254 478 479 480 482 484 369 386 390 458 460 459 461 521 509 504 503 502 501 500 499 498 415 Tyrosine-protein kinase ZAP-70
TYR ZAP70 ZAP70_HUMAN 4K2RA P43403 2 606 619.0 ANP:60702 ATPlike Inactive DFGin 5.928 12.438 BLAplus -138.85, 178.0 51.18, 49.01 -84.24, -35.32 31.27, 105.54 -104.96, 20.24 out-out out 14.113 Saltbr-out 13.985 HRD-out -89.83, 129.13 -108.05, -14.5 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -15.2 APE8-dihe-out -67.79, 10.24 APE8-rot-na 350.79 APE67-dihe-in -82.13, -29.45 -101.33, 20.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 12.27 D461N None None XRAY 3.0 0.213 0.287 A 614 543 17 0 0 17 [[338, 595]] 1.0 4k2r TYR_ZAP70_HUMAN TYR 8.6e-89 303.4 6 259 254 478 479 480 482 484 369 386 390 458 460 459 461 521 509 504 503 502 501 500 499 498 415 Tyrosine-protein kinase ZAP-70

Ligand: ANP

Total number of chains: 536
Active chains: 102
Total number of genes: 123
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 231 43.1% 8QCGA
DFGin BLBplus 158 29.5% 2SRCA
DFGin None 35 6.5% 6BXIA
DFGin ABAminus 34 6.3% 8R5EA
DFGin BLBtrans 34 6.3% 5X2AB
None None 12 2.2% 4IX5A
DFGin BLBminus 11 2.1% 4LGDA
DFGinter None 10 1.9% 7OPOG
DFGout None 6 1.1% 4I94A
DFGin BLAplus 5 0.9% 2OZOA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CKA1 CSK21_ARATH 6XX7A Q08467 77 406 409.0 ANP:60401 ATPlike Active DFGin 7.522 16.054 BLAminus -117.69, -174.69 54.04, 89.21 -108.75, 22.96 298.46, 82.8 -72.45, -17.87 in-in in 9.197 Saltbr-in 3.111 HRD-in -78.14, -48.74 65.41, 21.05 in-in-in SNCiii in-in ActLoopNT-in 2.834 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.12, 170.49 APE9-dihe-na 62.76, -171.63 APE8-dihe-in -114.91, 151.01 APE8-rot-in 304.83 APE67-dihe-in -66.49, -17.41 -50.66, -50.22 APE12-dist-in 12.585 APE11-dist-in 10.283 APE10-dist-in 6.188 APE9-dist-in 3.134 None None None XRAY 2.4 0.198 0.246 A 342 330 0 0 0 0 [[110, 395]] 1.0 6xx7 Arabidopsis thaliana CMGC_CKA1_ARATH CMGC 2.6e-65 226.5 1 301 301 245 246 247 249 251 139 152 156 224 226 225 227 285 272 267 266 265 264 263 262 261 185 Casein kinase II subunit alpha-1
CMGC MPK4 MPK4_ARATH 7W5CA Q39024 18 372 376.0 ANP:401 ATPlike Inactive DFGin 6.744 16.225 BLAminus -128.66, -171.29 63.4, 64.26 -92.17, 14.29 279.32, 65.56 -68.22, -18.9 in-in in 9.01 Saltbr-in 3.579 HRD-in -71.53, -46.63 78.29, -8.64 in-in-out SNCiio in-out ActLoopNT-in 2.703 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -115.93, 157.72 APE9-dihe-na -84.69, 1.94 APE8-dihe-in -132.03, 98.21 APE8-rot-out 46.99 APE67-dihe-in -68.07, -19.68 -80.43, -5.49 APE12-dist-out 6.233 APE11-dist-in 10.904 APE10-dist-out 8.979 APE9-dist-out 11.674 None None None XRAY 2.201 0.179 0.225 A 355 355 0 0 0 0 [[44, 329]] 1.0 7w5c Arabidopsis thaliana CMGC_MPK4_ARATH CMGC 1.3e-82 283.5 4 301 298 186 187 188 190 192 72 90 94 166 168 167 169 226 213 208 207 206 205 204 203 202 125 Mitogen-activated protein kinase 4
OTHER BSK8 BSK8_ARATH 4I94A Q9FHD7 40 328 487.0 ANP:60401 ATPlike Pseudo DFGout 11.087 4.579 None -62.85, 129.32 -64.9, -25.87 -61.66, -30.07 297.42, 140.17 -78.36, -1.16 out-out out 12.492 Saltbr-out 11.168 HRD-na-V -138.88, 128.41 -94.79, 85.21 out-out-out SNCooo out-out ActLoopNT-out 8.116 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -112.72, -1.39 APE9-dihe-na -99.73, 174.6 APE8-dihe-in -44.04, 124.87 APE8-rot-na 191.2 APE67-dihe-in -63.8, -11.97 -65.3, -25.56 APE12-dist-in 9.651 APE11-dist-in 13.035 APE10-dist-out 13.738 APE9-dist-out 9.019 None None None XRAY 1.8 0.176 0.218 A 300 289 0 0 0 0 [[64, 311]] 1.0 4i94 Arabidopsis thaliana OTHER_BSK8_ARATH TKL 1.8e-32 119.0 14 264 251 198 199 200 202 204 87 103 107 178 180 179 181 234 222 217 216 215 214 213 212 211 133 Serine/threonine-protein kinase BSK8
OTHER BSK8 BSK8_ARATH 4I94B Q9FHD7 40 328 487.0 ANP:60401 ATPlike Pseudo DFGout 11.167 4.564 None -61.22, 131.83 -70.76, -19.93 -64.01, -28.32 298.7, 142.58 -77.56, -3.78 out-out out 12.61 Saltbr-out 11.562 HRD-na-V -138.23, 125.02 -91.22, 87.17 out-out-out SNCooo out-out ActLoopNT-out 8.121 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -107.48, -5.73 APE9-dihe-na -87.26, 179.81 APE8-dihe-in -41.52, 121.65 APE8-rot-na 191.74 APE67-dihe-in -60.71, -19.43 -60.4, -25.91 APE12-dist-in 9.638 APE11-dist-in 12.966 APE10-dist-out 14.136 APE9-dist-out 9.048 None None None XRAY 1.8 0.176 0.218 B 300 289 0 0 0 0 [[64, 311]] 1.0 4i94 Arabidopsis thaliana OTHER_BSK8_ARATH TKL 1.8e-32 119.0 14 264 251 198 199 200 202 204 87 103 107 178 180 179 181 234 222 217 216 215 214 213 212 211 133 Serine/threonine-protein kinase BSK8
TKL BAK1 BAK1_ARATH 3UIMA Q94F62 272 573 615.0 ANP:1000 ATPlike Inactive DFGin 8.852 13.207 BLAminus -115.13, -165.77 41.37, 88.34 -98.5, 43.81 308.93, 97.2 -70.58, -44.49 in-out in 8.281 Saltbr-out 5.242 HRD-in -79.94, -53.3 85.37, -6.05 out-in-none SNCoin in-none ActLoopNT-in 2.641 ActLoopCT-none nonTYR APEdihe_aaini APEdist_iiii APE10-dihe-na -138.37, 177.14 APE9-dihe-na 106.88, -163.48 APE8-dihe-in -113.09, 162.35 APE8-rot-none 999.0 APE67-dihe-in -50.4, -34.12 -54.05, -40.71 APE12-dist-in 10.912 APE11-dist-in 11.3 APE10-dist-in 7.414 APE9-dist-in 5.319 None SEP290,TPO312,TPO446,TPO449,TPO450,TPO455 SEP290,TPO312,TPO446,TPO449,TPO450,TPO455 XRAY 2.2 0.237 0.277 A 326 297 5 0 0 0 [[288, 565]] 1.0 3uim Arabidopsis thaliana TKL_BAK1_ARATH TKL 5.8e-64 222.2 4 266 263 433 434 435 437 439 317 334 338 413 415 414 416 474 462 457 456 455 454 453 452 451 364 BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1
TKL BRI1 BRI1_ARATH 5LPVA O22476 867 1160 1196.0 ANP:1200 ATPlike Active DFGin 5.144 14.999 BLAminus -125.7, -177.27 57.44, 79.7 -100.2, 28.83 289.11, 69.34 -64.8, -27.23 in-in in 8.616 Saltbr-in 2.692 HRD-in -72.39, -48.96 69.78, 4.25 in-in-in SNCiii in-in ActLoopNT-in 2.973 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.4, 152.93 APE9-dihe-na 138.14, -175.87 APE8-dihe-in -122.84, 131.25 APE8-rot-in 310.37 APE67-dihe-inflip 103.25, -12.92 -53.02, 126.73 APE12-dist-in 9.499 APE11-dist-in 11.435 APE10-dist-in 5.667 APE9-dist-in 3.671 T872A TPO1039,SEP1042,SEP1044 TPO1039,SEP1042,SEP1044 XRAY 2.7 0.193 0.233 A 296 285 9 0 0 0 [[882, 1157]] 1.0 5lpv Arabidopsis thaliana TKL_BRI1_ARATH TKL 2e-63 220.4 4 266 263 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL BRI1 BRI1_ARATH 4OH4A O22476 863 1160 1196.0 ANP:61201 ATPlike Active DFGin 5.109 14.621 BLAminus -140.27, -170.9 60.42, 81.58 -96.75, 17.94 285.65, 72.49 -62.14, -24.45 in-in in 8.43 Saltbr-in 2.981 HRD-in -67.48, -45.07 71.79, 0.23 in-in-in SNCiii in-in ActLoopNT-in 2.871 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.28, 137.25 APE9-dihe-na 143.97, 175.71 APE8-dihe-in -113.05, 131.41 APE8-rot-in 300.18 APE67-dihe-inflip 103.6, -22.59 -52.56, 134.8 APE12-dist-in 10.688 APE11-dist-in 12.06 APE10-dist-in 6.328 APE9-dist-in 4.124 None TPO1039,SEP1042,SEP1044,SEP1060 TPO1039,SEP1042,SEP1044,SEP1060 XRAY 2.25 0.203 0.236 A 333 292 6 0 0 0 [[882, 1157]] 1.0 4oh4 Arabidopsis thaliana TKL_BRI1_ARATH TKL 3e-63 219.8 4 266 263 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL BRI1 BRI1_ARATH 4OH4B O22476 867 1160 1196.0 ANP:61201 ATPlike Active DFGin 5.028 14.866 BLAminus -128.92, -179.57 66.05, 81.1 -97.08, 13.19 285.07, 69.22 -52.61, -27.46 in-in in 8.604 Saltbr-in 2.585 HRD-in -68.96, -46.37 73.67, -10.15 in-in-in SNCiii in-in ActLoopNT-in 2.87 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.43, 142.85 APE9-dihe-na 162.33, 170.81 APE8-dihe-in -132.62, 128.73 APE8-rot-in 297.7 APE67-dihe-inflip 104.71, -30.59 -48.41, 132.44 APE12-dist-in 9.471 APE11-dist-in 10.311 APE10-dist-in 5.146 APE9-dist-in 4.053 None TPO1039,SEP1042,SEP1044,SEP1060 TPO1039,SEP1042,SEP1044,SEP1060 XRAY 2.25 0.203 0.236 B 333 283 11 0 0 0 [[882, 1157]] 1.0 4oh4 Arabidopsis thaliana TKL_BRI1_ARATH TKL 3e-63 219.8 4 266 263 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL BRI1 BRI1_ARATH 4Q5JA O22476 863 1160 1196.0 ANP:61201 ATPlike Active DFGin 5.066 14.74 BLAminus -137.9, 174.67 63.19, 85.3 -100.14, 20.42 284.87, 74.71 -62.5, -33.31 in-in in 8.354 Saltbr-in 3.257 HRD-in -68.22, -43.45 65.77, 3.93 in-in-in SNCiii in-in ActLoopNT-in 2.662 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.48, 139.01 APE9-dihe-na 175.24, 173.84 APE8-dihe-in -115.42, 129.74 APE8-rot-in 289.59 APE67-dihe-inflip 96.87, -1.52 -53.59, 124.31 APE12-dist-in 10.51 APE11-dist-in 12.065 APE10-dist-in 6.236 APE9-dist-in 4.467 None TPO1039,SEP1042,SEP1044,SEP1060 MSE925,MSE928,MSE959,MSE1010,MSE1030,MSE1034,MSE1037,TPO1039,SEP1042,SEP1044,SEP1060,MSE1117,MSE1148,MSE1152,MSE1154 XRAY 2.772 0.203 0.259 A 341 287 11 0 0 0 [[882, 1157]] 1.0 4q5j Arabidopsis thaliana TKL_BRI1_ARATH TKL 3.2e-63 219.7 4 266 263 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL BRI1 BRI1_ARATH 4Q5JB O22476 867 1160 1196.0 ANP:61201 ATPlike Active DFGin 5.259 14.8 BLAminus -126.47, -178.56 58.45, 93.89 -112.89, 22.9 283.23, 71.66 -57.4, -19.56 in-in in 8.732 Saltbr-in 3.184 HRD-in -81.55, -35.96 67.72, -5.15 in-in-in SNCiii in-in ActLoopNT-in 2.775 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -167.14, 134.16 APE9-dihe-na 157.62, 164.27 APE8-dihe-in -126.08, 123.8 APE8-rot-in 304.99 APE67-dihe-inflip 120.44, -28.11 -46.98, 122.06 APE12-dist-in 9.403 APE11-dist-in 10.636 APE10-dist-in 5.512 APE9-dist-in 4.081 None TPO1039,SEP1042,SEP1044,SEP1060 MSE925,MSE928,MSE959,MSE1010,MSE1030,MSE1034,MSE1037,TPO1039,SEP1042,SEP1044,SEP1060,MSE1117,MSE1148,MSE1152,MSE1154 XRAY 2.772 0.203 0.259 B 341 283 11 0 0 0 [[882, 1157]] 1.0 4q5j Arabidopsis thaliana TKL_BRI1_ARATH TKL 3.2e-63 219.7 4 266 263 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL CARK1 CARK1_ARATH 5XD6A Q9LUT0 50 350 364.0 ANP:61000 ATPlike Inactive DFGin 5.287 13.989 None -82.23, -179.6 -66.2, 154.72 -113.7, 177.91 45.1, 88.76 -91.38, 112.57 out-na out 13.41 Saltbr-na 13.476 HRD-in -67.99, -48.34 77.3, -6.84 na-out-none SNCaon out-none ActLoopNT-out 8.296 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 12.83 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.898 0.218 0.251 A 305 278 23 0 0 17 [[67, 347]] 1.0 5xd6 Arabidopsis thaliana TKL_CARK1_ARATH TKL 9e-61 211.7 4 266 263 216 217 218 220 222 97 112 116 196 198 197 199 258 246 241 240 239 238 237 236 235 142 Protein CYTOSOLIC ABA RECEPTOR KINASE 1
TKL CARK1 CARK1_ARATH 5XD6B Q9LUT0 50 350 364.0 ANP:61000 ATPlike Inactive DFGin 5.63 13.93 None -77.44, -177.16 -70.67, 157.78 -117.63, 177.11 50.67, 89.87 -85.72, 109.22 out-na out 13.676 Saltbr-na 14.086 HRD-in -75.16, -46.81 74.28, -9.17 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -2.12 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.898 0.218 0.251 B 305 282 19 0 0 19 [[67, 347]] 1.0 5xd6 Arabidopsis thaliana TKL_CARK1_ARATH TKL 9e-61 211.7 4 266 263 216 217 218 220 222 97 112 116 196 198 197 199 258 246 241 240 239 238 237 236 235 142 Protein CYTOSOLIC ABA RECEPTOR KINASE 1
TKL SOBIR1 SBIR1_ARATH 7CTVA Q9SKB2 326 639 641.0 ANP:60702 ATPlike Inactive DFGin 6.661 13.885 BLBminus -141.13, -179.6 54.72, 58.77 -66.01, 150.7 286.65, 72.17 -81.72, 124.12 out-none out 15.112 Saltbr-none 999.0 HRD-out -87.3, 102.63 -86.62, 6.82 none-out-out SNCnoo out-out ActLoopNT-out 9.521 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -76.63, -5.1 APE9-dihe-na 65.07, 35.87 APE8-dihe-out -126.08, 24.51 APE8-rot-out 59.01 APE67-dihe-in -54.76, -18.48 -67.58, -32.17 APE12-dist-out 20.762 APE11-dist-out 20.491 APE10-dist-out 17.179 APE9-dist-out 13.97 D489A None None XRAY 2.886 0.218 0.239 A 336 297 17 0 0 0 [[343, 638]] 1.0 7ctv Arabidopsis thaliana TKL_SOBIR1_ARATH TKL 8.4e-57 198.7 4 266 263 506 507 508 510 512 377 407 411 486 488 487 489 548 536 531 530 529 528 527 526 525 437 Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1
TKL SOBIR1 SBIR1_ARATH 7CTVB Q9SKB2 326 640 641.0 ANP:60702 ATPlike Inactive DFGin 6.421 13.87 BLBminus -144.86, -178.02 49.22, 64.23 -62.65, 147.84 294.25, 70.22 -69.54, 92.84 out-none out 15.253 Saltbr-none 999.0 HRD-out -90.69, 89.36 -71.79, -21.49 none-out-out SNCnoo out-out ActLoopNT-out 9.121 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -77.41, -5.23 APE9-dihe-na 69.76, 25.67 APE8-dihe-out -112.95, 17.98 APE8-rot-out 72.42 APE67-dihe-in -62.91, -23.09 -65.66, -31.24 APE12-dist-out 20.132 APE11-dist-out 19.759 APE10-dist-out 16.431 APE9-dist-out 13.633 D489A None None XRAY 2.886 0.218 0.239 B 336 292 23 0 0 0 [[343, 638]] 1.0 7ctv Arabidopsis thaliana TKL_SOBIR1_ARATH TKL 8.4e-57 198.7 4 266 263 506 507 508 510 512 377 407 411 486 488 487 489 548 536 531 530 529 528 527 526 525 437 Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1
TKL SOBIR1 SBIR1_ARATH 7CTXA Q9SKB2 326 639 641.0 ANP:60701 ATPlike Inactive DFGin 5.925 13.958 BLBplus -138.51, 171.55 56.64, 47.79 -120.23, 164.88 60.27, 92.94 88.0, -43.52 out-out out 14.426 Saltbr-out 14.62 HRD-in -69.62, -53.51 75.07, -7.08 out-out-out SNCooo out-out ActLoopNT-out 8.647 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -78.29, -6.92 APE9-dihe-na 74.92, 27.29 APE8-dihe-out -123.12, 22.17 APE8-rot-out 54.06 APE67-dihe-in -63.92, -13.63 -66.83, -19.82 APE12-dist-out 21.872 APE11-dist-out 21.46 APE10-dist-out 18.282 APE9-dist-out 14.121 None None None XRAY 2.907 0.226 0.243 A 323 293 8 0 0 0 [[343, 638]] 1.0 7ctx Arabidopsis thaliana TKL_SOBIR1_ARATH TKL 1.3e-59 207.9 4 266 263 506 507 508 510 512 377 407 411 486 488 487 489 548 536 531 530 529 528 527 526 525 437 Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1
TKL SOBIR1 SBIR1_ARATH 7CTXB Q9SKB2 326 640 641.0 ANP:60701 ATPlike Inactive DFGin 5.875 13.993 BLBplus -137.44, 176.16 58.26, 44.88 -125.18, 162.12 65.68, 87.66 87.14, -0.96 out-out out 14.063 Saltbr-out 13.631 HRD-in -66.8, -55.86 75.55, -4.98 out-out-out SNCooo out-out ActLoopNT-out 8.85 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -76.44, -5.32 APE9-dihe-na 71.29, 28.46 APE8-dihe-out -125.93, 28.87 APE8-rot-out 53.38 APE67-dihe-in -62.75, -12.89 -73.08, -23.74 APE12-dist-out 21.618 APE11-dist-out 21.328 APE10-dist-out 18.191 APE9-dist-out 14.316 None None None XRAY 2.907 0.226 0.243 B 323 297 5 0 0 0 [[343, 638]] 1.0 7ctx Arabidopsis thaliana TKL_SOBIR1_ARATH TKL 1.3e-59 207.9 4 266 263 506 507 508 510 512 377 407 411 486 488 487 489 548 536 531 530 529 528 527 526 525 437 Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1
AGC PRKACA KAPCA_BOVIN 9DW5G P00517 13 351 351.0 ANP:403 ATPlike Inactive DFGin 7.334 15.877 BLAminus -126.22, -169.89 60.75, 61.77 -87.02, 21.16 273.51, 93.96 -63.0, -33.74 out-none out 10.252 Saltbr-none 999.0 HRD-in -80.85, -56.62 73.43, -6.68 none-in-in SNCnii in-in ActLoopNT-in 2.782 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -167.11, -173.97 APE9-dihe-na 106.0, -157.25 APE8-dihe-in -108.29, 136.12 APE8-rot-in 326.0 APE67-dihe-in -63.46, -43.06 -59.57, -33.75 APE12-dist-in 9.113 APE11-dist-in 11.955 APE10-dist-in 6.81 APE9-dist-in 4.563 None TPO198 TPO198 EM 3.8 999.0 999.0 G 351 330 0 0 0 0 [[44, 298]] 1.0 9dw5 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 9DW8G P00517 15 329 351.0 ANP:403 ATPlike None DFGin 6.07 14.235 BLAminus -131.43, -174.72 59.27, 66.66 -86.28, 33.46 293.19, 93.28 -61.23, -49.05 in-none in 9.911 Saltbr-none 999.0 HRD-in -98.32, -49.71 57.42, 11.15 none-in-in SNCnii in-in ActLoopNT-in 2.961 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -168.06, 160.73 APE9-dihe-na 123.3, -175.7 APE8-dihe-in -89.52, 132.72 APE8-rot-in 298.44 APE67-dihe-in -69.93, -27.98 -56.75, -38.6 APE12-dist-in 8.7 APE11-dist-in 11.593 APE10-dist-in 6.411 APE9-dist-in 4.803 None TPO198 TPO198 EM 3.5 999.0 999.0 G 351 309 0 0 0 0 [[44, 298]] 1.0 9dw8 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 9DW7G P00517 13 351 351.0 ANP:403 ATPlike Inactive None 999.0 999.0 None -155.4, -162.2 59.11, 63.62 -70.57, 12.19 999.0, 999.0 -65.51, -34.83 out-none out 10.971 Saltbr-none 999.0 HRD-in -65.14, -55.26 50.7, 27.28 none-in-out SNCnio in-out ActLoopNT-in 2.575 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iiio APE10-dihe-na -166.96, 170.69 APE9-dihe-na 108.98, -156.8 APE8-dihe-in -102.79, 139.06 APE8-rot-none 999.0 APE67-dihe-in -58.63, -28.81 -67.98, -6.96 APE12-dist-in 9.228 APE11-dist-in 10.267 APE10-dist-in 6.438 APE9-dist-out 6.202 None None None EM 6.0 999.0 999.0 G 351 339 0 0 0 0 [[44, 298]] 1.0 9dw7 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
TYR LET23 LET23_CAEEL 5WNOA P24348 876 1190 1323.0 ANP:1201 ATPlike Inactive DFGin 6.247 12.877 BLBplus -129.17, 177.47 55.99, 43.49 -103.44, 159.44 53.09, 86.5 67.88, 29.06 out-out out 14.465 Saltbr-out 14.517 HRD-in -74.41, -38.75 70.96, -11.0 out-out-out SNCooo out-out ActLoopNT-out 7.638 ActLoopCT-out TYR APEdihe_nooai APEdist_aaao APE10-dihe-none 999.0, -139.66 APE9-dihe-out -62.23, -13.83 APE8-dihe-out -67.85, 10.53 APE8-rot-na 999.0 APE67-dihe-in -61.61, -23.35 -63.66, -29.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.694 APE9-dist-out 10.859 None None None XRAY 2.386 0.217 0.247 A 330 302 13 0 0 12 [[885, 1143]] 1.0 5wno Caenorhabditis elegans TYR_LET23_CAEEL TYR 1.6e-78 269.6 2 260 259 1027 1028 1029 1031 1033 919 934 938 1007 1009 1008 1010 1069 1057 1052 1051 1050 1049 1048 1047 1046 964 Receptor tyrosine-protein kinase let-23
CMGC CK2 Q5KF69_CRYD1 6ISEA Q5KF69 5 331 336.0 ANP:403 ATPlike Active DFGin 7.339 16.208 BLAminus -129.3, -170.99 44.36, 71.77 -91.05, 22.67 299.01, 82.29 -66.02, -23.99 in-in in 9.482 Saltbr-in 3.336 HRD-in -65.48, -54.09 76.82, 9.27 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.0, -19.23 APE9-dihe-na -99.69, -172.72 APE8-dihe-in -80.09, 147.5 APE8-rot-in 301.93 APE67-dihe-in -61.24, -16.59 -47.75, -58.81 APE12-dist-in 12.687 APE11-dist-in 10.631 APE10-dist-in 6.144 APE9-dist-in 3.609 None None None XRAY 2.8 0.198 0.23 A 338 327 0 0 0 0 [[38, 323]] 1.0 6ise Cryptococcus deneoformans CMGC_CK2_CRYD1 CMGC 6e-64 222.0 1 301 301 173 174 175 177 179 67 80 84 152 154 153 155 213 200 195 194 193 192 191 190 189 113 Casein kinase II subunit alpha
CMGC CK2 Q5KF69_CRYD1 6ISEB Q5KF69 5 331 336.0 ANP:403 ATPlike Active DFGin 7.308 16.238 BLAminus -133.11, -171.48 44.36, 73.35 -91.98, 23.51 299.28, 79.86 -68.68, -21.78 in-in in 9.591 Saltbr-in 3.496 HRD-in -67.7, -51.8 75.87, 7.92 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.38, 168.0 APE9-dihe-na 74.76, -173.48 APE8-dihe-in -110.86, 148.66 APE8-rot-in 271.82 APE67-dihe-in -65.62, -23.31 -54.68, -45.78 APE12-dist-in 12.576 APE11-dist-in 10.311 APE10-dist-in 6.266 APE9-dist-in 3.367 None None None XRAY 2.8 0.198 0.23 B 338 327 0 0 0 0 [[38, 323]] 1.0 6ise Cryptococcus deneoformans CMGC_CK2_CRYD1 CMGC 6e-64 222.0 1 301 301 173 174 175 177 179 67 80 84 152 154 153 155 213 200 195 194 193 192 191 190 189 113 Casein kinase II subunit alpha
CMGC CKA1 J9VNH4_CRYN9 6KO6B J9VNH4 5 334 338.0 ANP:401 ATPlike Active DFGin 7.298 16.236 BLAminus -115.02, -165.9 52.87, 72.55 -94.97, 21.12 299.2, 77.23 -71.99, -18.35 in-in in 9.324 Saltbr-in 3.151 HRD-in -64.53, -49.64 63.27, 19.41 in-in-in SNCiii in-in ActLoopNT-in 3.055 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.45, 156.98 APE9-dihe-na 76.83, -179.82 APE8-dihe-in -92.38, 159.35 APE8-rot-in 277.62 APE67-dihe-in -71.62, -13.46 -53.06, -52.26 APE12-dist-in 12.792 APE11-dist-in 10.474 APE10-dist-in 6.177 APE9-dist-in 3.249 None None None XRAY 2.4 0.238 0.268 B 338 330 0 0 0 0 [[38, 323]] 1.0 6ko6 Cryptococcus neoformans CMGC_CKA1_CRYN9 CMGC 6e-64 222.0 1 301 301 173 174 175 177 179 67 80 84 152 154 153 155 213 200 195 194 193 192 191 190 189 113 Casein kinase II subunit alpha
CAMK CDPK1 A3FQ16_CRYPI 3IGOA A3FQ16 70 537 538.0 ANP:60610 ATPlike Inactive DFGin 6.707 13.465 BLBplus -121.25, 174.97 67.47, 60.04 -154.02, 168.86 59.26, 84.09 92.58, -14.73 out-out out 14.209 Saltbr-out 13.065 HRD-in -63.43, -55.21 83.61, -21.71 out-out-out SNCooo out-out ActLoopNT-out 9.03 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 153.6 APE8-rot-out 169.15 APE67-dihe-in -51.84, -35.84 -53.96, -31.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.25 0.205 0.258 A 486 445 8 0 0 7 [[76, 332]] 1.0 3igo Cryptosporidium parvum CAMK_CDPK1_CRYPI CAMK 3.4e-90 308.1 1 256 256 218 219 220 222 224 105 123 127 195 197 196 198 256 245 240 239 238 237 236 235 234 153 non-specific serine/threonine protein kinase
CAMK CDPK3 Q5CS01_CRYPI 3LIJA Q5CS01 42 516 523.0 ANP:60522 ATPlike Inactive DFGin 7.034 14.655 BLAminus -127.46, 177.5 59.13, 85.54 -100.29, 19.94 282.89, 79.61 -59.37, -32.9 out-out out 10.177 Saltbr-out 5.256 HRD-in -74.61, -49.83 71.32, -4.41 out-in-in SNCoii in-in ActLoopNT-in 2.936 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.48, 149.72 APE9-dihe-na 141.55, -153.66 APE8-dihe-in -128.1, 132.61 APE8-rot-in 307.4 APE67-dihe-in -65.62, -35.53 -34.47, -55.78 APE12-dist-in 8.691 APE11-dist-in 11.66 APE10-dist-in 5.782 APE9-dist-in 3.569 None None None XRAY 1.9 0.203 0.229 A 494 461 8 0 0 0 [[62, 318]] 1.0 3lij Cryptosporidium parvum CAMK_CDPK3_CRYPI CAMK 2.7e-91 311.6 1 256 256 204 205 206 208 210 91 109 113 181 183 182 184 242 231 226 225 224 223 222 221 220 139 Calcium-dependent protein kinase 1
CAMK CDPK4-2 Q5CZ29_CRYPI 3HKOA Q5CZ29 126 452 824.0 ANP:60329 ATPlike Inactive DFGin 5.952 15.583 ABAminus -120.43, 2.55 -135.28, 127.73 -128.94, 23.59 286.29, 84.57 -62.1, -26.95 out-out out 10.111 Saltbr-out 4.434 HRD-in -76.09, -50.74 72.63, 1.72 out-in-out SNCoio in-out ActLoopNT-in 2.773 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, -104.24 APE9-dihe-na 126.39, -179.13 APE8-dihe-in -75.92, 124.68 APE8-rot-in 280.37 APE67-dihe-in -53.45, -34.89 -49.78, -39.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.406 APE9-dist-in 3.722 None None None XRAY 1.8 0.204 0.246 A 345 314 13 0 0 8 [[135, 237], [261, 441]] 2.0 3hko Cryptosporidium parvum CAMK_CDPK4-2_CRYPI CAMK 1.5e-19 241.1 1 89 250 319 320 321 323 325 164 185 189 297 299 298 300 365 351 346 345 344 343 342 341 340 215 non-specific serine/threonine protein kinase
CMGC BSK JNK_DROME 5AWMA P92208 7 362 372.0 ANP:401 ATPlike Inactive DFGin 3.968 14.304 ABAminus -88.58, -21.58 -138.57, 174.5 -114.07, -2.87 300.82, 95.37 86.6, -153.47 out-out out 10.429 Saltbr-out 5.258 HRD-in -75.17, -58.38 75.26, -11.27 out-out-out SNCooo out-out ActLoopNT-out 6.357 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -11.69 APE9-dihe-na -122.62, 142.03 APE8-dihe-in -71.85, 116.06 APE8-rot-in 300.48 APE67-dihe-in -65.6, -18.22 -112.19, 0.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.382 APE9-dist-out 11.166 None None None XRAY 1.79 0.179 0.22 A 394 345 9 0 0 3 [[24, 320]] 1.0 5awm Drosophila melanogaster CMGC_BSK_DROME CMGC 8.1e-82 280.8 1 301 301 166 167 168 170 172 53 71 75 146 148 147 149 205 193 188 187 186 185 184 183 182 107 Stress-activated protein kinase JNK
STE DSOR1 DSOR1_DROME 8BW9C Q24324 81 384 396.0 ANP:60401,QOM:60402 ATPlike,Type3 Inactive DFGin 5.477 14.249 BLBplus -159.47, 168.77 62.79, 56.43 -107.18, 135.07 48.27, 89.36 -64.21, 107.83 out-out out 15.559 Saltbr-out 19.84 HRD-in -58.37, -64.17 71.81, -9.38 out-out-out SNCooo out-out ActLoopNT-out 8.849 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -115.48, -57.78 APE9-dihe-na 75.76, 170.55 APE8-dihe-out -89.06, -0.85 APE8-rot-out 170.28 APE67-dihe-out -125.12, 142.75 -125.31, 123.31 APE12-dist-out 17.384 APE11-dist-out 19.526 APE10-dist-out 21.999 APE9-dist-out 14.644 None None None EM 3.32 999.0 999.0 C 396 280 24 0 0 0 [[87, 364]] 1.0 8bw9 Drosophila melanogaster STE_DSOR1_DROME STE 2.5e-90 308.3 2 256 255 226 227 228 230 232 116 133 137 206 208 207 209 264 252 247 246 245 244 243 242 241 163 Dual specificity mitogen-activated protein kinase kinase dSOR1
TYR PTK2 FAK1_CHICK 2J0LA Q00944 411 686 1053.0 ANP:1689 ATPlike Inactive DFGin 7.042 15.595 BLAminus -124.12, -151.88 51.86, 82.15 -108.03, 32.91 286.36, 85.03 -71.96, -36.63 in-in in 7.824 Saltbr-in 2.777 HRD-in -78.92, -53.9 78.76, -8.92 in-in-out SNCiio in-out ActLoopNT-in 2.956 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -71.98, 100.38 APE9-dihe-in -65.3, 130.79 APE8-dihe-in -75.31, 71.06 APE8-rot-na 28.66 APE67-dihe-in -69.29, -16.82 -49.9, -41.21 APE12-dist-na 11.387 APE11-dist-na 10.256 APE10-dist-na 13.533 APE9-dist-out 8.279 None PTR576,PTR577 PTR576,PTR577 XRAY 2.3 0.217 0.263 A 276 276 0 0 0 0 [[422, 678]] 1.0 2j0l Gallus gallus TYR_PTK2_CHICK TYR 2.6e-93 318.0 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 6TY4A Q00944 34 686 1053.0 ANP:702 ATPlike Active DFGin 7.546 15.951 BLAminus -124.05, -151.88 51.86, 82.13 -107.99, 32.9 286.39, 85.0 -72.01, -36.58 in-in in 8.437 Saltbr-in 3.562 HRD-in -70.16, -30.0 74.19, -18.38 in-in-in SNCiii in-in ActLoopNT-in 2.815 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.31, 66.54 APE9-dihe-in -63.31, 139.75 APE8-dihe-in -64.41, 127.23 APE8-rot-na 22.65 APE67-dihe-in -56.19, -42.03 -70.19, -41.73 APE12-dist-na 11.489 APE11-dist-na 10.184 APE10-dist-na 13.636 APE9-dist-in 7.205 None None None EM 5.96 999.0 999.0 A 658 621 0 0 0 0 [[422, 678]] 1.0 6ty4 Gallus gallus TYR_PTK2_CHICK TYR 1.5e-91 312.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 6TY4B Q00944 34 686 1053.0 ANP:702 ATPlike Active DFGin 7.546 15.95 BLAminus -124.03, -151.9 51.82, 82.14 -107.99, 32.89 286.33, 85.06 -71.97, -36.56 in-in in 8.436 Saltbr-in 3.562 HRD-in -70.15, -30.0 74.26, -18.38 in-in-in SNCiii in-in ActLoopNT-in 2.815 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.3, 66.56 APE9-dihe-in -63.34, 139.79 APE8-dihe-in -64.42, 127.23 APE8-rot-na 22.65 APE67-dihe-in -56.21, -42.01 -70.19, -41.71 APE12-dist-na 11.489 APE11-dist-na 10.183 APE10-dist-na 13.636 APE9-dist-in 7.205 None None None EM 5.96 999.0 999.0 B 658 621 0 0 0 0 [[422, 678]] 1.0 6ty4 Gallus gallus TYR_PTK2_CHICK TYR 1.5e-91 312.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
AGC AKT1 AKT1_HUMAN 4EKKA P31749 144 477 480.0 ANP:60501 ATPlike Active DFGin 6.048 13.113 BLAminus -112.5, -177.27 66.46, 90.66 -111.95, 23.34 296.26, 86.16 -69.26, -23.9 in-in in 8.651 Saltbr-in 2.978 HRD-in -63.51, -40.13 66.5, -18.58 in-in-in SNCiii in-in ActLoopNT-in 3.05 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.71, 172.01 APE9-dihe-na 121.09, -152.4 APE8-dihe-in -119.32, 125.09 APE8-rot-in 285.38 APE67-dihe-in -63.61, -25.53 -44.69, -42.52 APE12-dist-in 8.814 APE11-dist-in 11.718 APE10-dist-in 6.07 APE9-dist-in 4.069 S473D TPO308 TPO308 XRAY 2.8 0.22 0.28 A 341 319 0 0 0 0 [[150, 408]] 1.0 4ekk Homo sapiens AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT1 AKT1_HUMAN 4EKKB P31749 144 477 480.0 ANP:60501 ATPlike Active DFGin 6.075 13.046 BLAminus -112.98, 175.61 60.18, 117.01 -127.72, 18.67 304.81, 92.19 -54.85, -36.32 in-in in 8.766 Saltbr-in 2.665 HRD-in -65.56, -47.0 73.75, -27.2 in-in-in SNCiii in-in ActLoopNT-in 2.819 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.2, 164.76 APE9-dihe-na 136.6, -155.35 APE8-dihe-in -114.57, 129.15 APE8-rot-in 273.31 APE67-dihe-in -63.86, -22.96 -45.74, -46.48 APE12-dist-in 8.77 APE11-dist-in 11.686 APE10-dist-in 6.125 APE9-dist-in 4.285 S473D TPO308 TPO308 XRAY 2.8 0.22 0.28 B 341 319 0 0 0 0 [[150, 408]] 1.0 4ekk Homo sapiens AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 1O6KA P31751 146 479 481.0 ANP:1480 ATPlike Active DFGin 6.146 12.734 BLAminus -120.8, -176.05 56.87, 82.9 -98.82, 24.49 299.36, 92.56 -61.37, -25.29 in-in in 8.749 Saltbr-in 2.796 HRD-in -73.34, -45.79 65.54, -9.2 in-in-in SNCiii in-in ActLoopNT-in 3.027 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.85, 170.7 APE9-dihe-na 130.02, -155.15 APE8-dihe-in -119.36, 127.57 APE8-rot-in 291.96 APE67-dihe-in -68.55, -16.48 -36.55, -56.12 APE12-dist-in 8.193 APE11-dist-in 11.759 APE10-dist-in 6.119 APE9-dist-in 3.921 S474D TPO309 TPO309 XRAY 1.7 0.205 0.234 A 336 318 0 0 0 0 [[152, 409]] 1.0 1o6k Homo sapiens AGC_AKT2_HUMAN AGC 1.7e-99 338.1 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC AKT2 AKT2_HUMAN 1O6LA P31751 146 477 481.0 ANP:61480 ATPlike Active DFGin 6.258 12.925 BLAminus -121.53, -178.18 58.41, 83.34 -98.83, 24.71 297.57, 89.85 -63.5, -19.94 in-in in 8.794 Saltbr-in 2.76 HRD-in -74.06, -43.29 62.88, -5.6 in-in-in SNCiii in-in ActLoopNT-in 3.006 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.79, 169.91 APE9-dihe-na 133.49, -153.33 APE8-dihe-in -120.8, 127.55 APE8-rot-in 289.07 APE67-dihe-in -68.04, -17.15 -37.13, -54.04 APE12-dist-in 8.173 APE11-dist-in 11.74 APE10-dist-in 6.122 APE9-dist-in 3.747 None TPO309 TPO309 XRAY 1.6 0.198 0.227 A 337 312 0 0 0 0 [[152, 409]] 1.0 1o6l Homo sapiens AGC_AKT2_HUMAN AGC 1.8e-99 338.1 1 260 260 292 293 294 296 298 181 200 204 272 274 273 275 332 320 315 314 313 312 311 310 309 230 RAC-beta serine/threonine-protein kinase
AGC GRK5 GRK5_HUMAN 4TNDA P34947 15 543 590.0 ANP:601 ATPlike Active DFGin 5.282 13.172 BLAminus -119.9, 173.82 59.88, 73.64 -89.53, 7.87 278.21, 112.8 -54.71, -33.69 in-in in 9.193 Saltbr-in 3.053 HRD-in -67.8, -56.87 74.64, -6.61 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.25, 150.21 APE9-dihe-na 143.02, -165.26 APE8-dihe-in -107.11, 142.28 APE8-rot-in 314.69 APE67-dihe-inflip 92.64, -22.22 -59.58, 132.94 APE12-dist-in 10.302 APE11-dist-in 12.056 APE10-dist-in 6.23 APE9-dist-in 4.255 None None None XRAY 1.802 0.174 0.205 A 590 529 0 0 0 0 [[186, 448]] 1.0 4tnd Homo sapiens AGC_GRK5_HUMAN AGC 1.1e-83 286.4 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK6 GRK6_HUMAN 2ACXA P43250 14 532 576.0 ANP:577 ATPlike Active DFGin 6.207 13.284 BLAminus -133.82, 164.79 58.79, 76.03 -96.19, 24.41 281.42, 82.4 -59.68, -24.05 in-in in 9.341 Saltbr-in 3.219 HRD-in -78.26, -56.85 77.2, -1.95 in-in-in SNCiii in-in ActLoopNT-in 2.971 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.49, 157.4 APE9-dihe-na 123.02, -168.26 APE8-dihe-in -95.03, 140.31 APE8-rot-in 303.17 APE67-dihe-in -86.56, -0.13 -45.11, -52.69 APE12-dist-in 10.478 APE11-dist-in 11.834 APE10-dist-in 6.083 APE9-dist-in 3.906 C561S,C562S,C565S None None XRAY 2.6 0.204 0.243 A 576 495 0 0 0 0 [[186, 448]] 1.0 2acx Homo sapiens AGC_GRK6_HUMAN AGC 2e-85 292.1 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 6
AGC GRK6 GRK6_HUMAN 2ACXB P43250 14 535 576.0 ANP:577 ATPlike Active DFGin 6.09 13.146 BLAminus -128.37, 163.87 55.35, 87.14 -100.56, 21.26 285.61, 77.77 -55.4, -30.56 in-in in 9.231 Saltbr-in 2.439 HRD-in -77.3, -59.12 75.78, 1.97 in-in-in SNCiii in-in ActLoopNT-in 2.977 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.83, 161.38 APE9-dihe-na 125.99, -167.44 APE8-dihe-in -95.89, 144.8 APE8-rot-in 307.19 APE67-dihe-in -70.72, -14.39 -48.06, -55.51 APE12-dist-in 10.477 APE11-dist-in 11.872 APE10-dist-in 6.167 APE9-dist-in 3.71 C561S,C562S,C565S None None XRAY 2.6 0.204 0.243 B 576 492 5 0 0 0 [[186, 448]] 1.0 2acx Homo sapiens AGC_GRK6_HUMAN AGC 2e-85 292.1 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 6
AGC PRKCB KPCB_HUMAN 8SE1A P05771 19 668 671.0 ANP:60706 ATPlike Active DFGin 6.007 12.839 BLAminus -130.5, -169.38 54.07, 70.37 -91.85, 35.76 301.77, 99.49 -89.35, 3.84 in-in in 8.337 Saltbr-in 2.524 HRD-in -91.65, -37.95 43.68, 28.8 in-in-in SNCiii in-in ActLoopNT-in 3.16 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.86, 170.42 APE9-dihe-na 126.28, -151.58 APE8-dihe-in -120.81, 128.88 APE8-rot-in 299.44 APE67-dihe-in -79.06, -41.06 -50.17, -27.42 APE12-dist-in 8.88 APE11-dist-in 12.178 APE10-dist-in 6.66 APE9-dist-in 3.611 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 3.32 0.202 0.256 A 674 607 0 0 0 0 [[342, 600]] 1.0 8se1 Homo sapiens AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC PRKCB KPCB_HUMAN 8SE1B P05771 19 668 671.0 ANP:60706 ATPlike Active DFGin 6.093 12.778 BLAminus -130.75, -169.0 53.85, 70.09 -92.15, 34.96 301.62, 99.67 -90.48, 2.45 in-in in 8.312 Saltbr-in 2.216 HRD-in -89.42, -35.84 47.27, 23.7 in-in-in SNCiii in-in ActLoopNT-in 3.284 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.83, 169.92 APE9-dihe-na 126.33, -152.59 APE8-dihe-in -121.43, 128.62 APE8-rot-in 299.3 APE67-dihe-in -78.67, -41.09 -50.34, -26.64 APE12-dist-in 8.722 APE11-dist-in 12.182 APE10-dist-in 6.709 APE9-dist-in 3.767 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 3.32 0.202 0.256 B 674 631 0 0 0 0 [[342, 600]] 1.0 8se1 Homo sapiens AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC PRKCB KPCB_HUMAN 8SE2B P05771 30 671 671.0 ANP:701 ATPlike Active DFGin 5.706 12.737 BLAminus -122.79, -175.57 50.54, 85.22 -103.07, 33.77 300.25, 95.58 -78.87, -5.25 in-in in 8.251 Saltbr-in 2.675 HRD-in -90.05, -48.77 75.62, -5.68 in-in-in SNCiii in-in ActLoopNT-in 3.126 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.22, 161.28 APE9-dihe-na 125.49, -179.08 APE8-dihe-in -100.09, 129.99 APE8-rot-in 297.02 APE67-dihe-in -66.56, -21.71 -49.98, -38.79 APE12-dist-in 8.634 APE11-dist-in 11.712 APE10-dist-in 6.223 APE9-dist-in 3.606 None TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 2.95 0.196 0.252 B 672 589 0 0 0 0 [[342, 600]] 1.0 8se2 Homo sapiens AGC_PRKCB_HUMAN AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
AGC PRKCI KPCI_HUMAN 8R3YI P41743 248 585 596.0 ANP:60601 ATPlike Inactive DFGin 6.372 12.488 ABAminus -142.84, 3.21 -114.63, 115.49 -97.57, 12.92 307.39, 117.32 -57.63, -54.79 in-out in 9.816 Saltbr-out 4.241 HRD-in -70.43, -26.71 66.29, -17.13 out-in-in SNCoii in-in ActLoopNT-in 2.908 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.32, 161.33 APE9-dihe-na 102.59, 162.36 APE8-dihe-in -70.48, 133.74 APE8-rot-in 297.7 APE67-dihe-in -64.44, -18.95 -54.13, -38.16 APE12-dist-in 8.863 APE11-dist-in 11.282 APE10-dist-in 5.856 APE9-dist-in 3.498 None TPO412,TPO564 TPO412,TPO564 EM 3.68 999.0 999.0 I 338 338 0 0 0 0 [[254, 522]] 1.0 8r3y Homo sapiens AGC_PRKCI_HUMAN AGC 1e-95 325.7 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 5LI1A P41743 248 589 596.0 ANP:60601 ATPlike Active DFGin 5.079 11.961 BLAminus -129.24, 176.98 73.22, 90.17 -103.83, 11.43 308.18, 130.49 -69.42, -18.98 in-in in 8.413 Saltbr-in 2.816 HRD-in -77.28, -52.44 73.77, 3.75 in-in-in SNCiii in-in ActLoopNT-in 2.975 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.65, 168.01 APE9-dihe-na 127.57, -168.6 APE8-dihe-in -111.48, 126.0 APE8-rot-in 296.01 APE67-dihe-in -54.62, -31.15 -46.95, -45.66 APE12-dist-in 8.752 APE11-dist-in 11.822 APE10-dist-in 6.31 APE9-dist-in 3.517 None TPO412,SEP484,TPO564 TPO412,SEP484,TPO564 XRAY 2.0 0.154 0.217 A 354 332 10 0 0 0 [[254, 522]] 1.0 5li1 Homo sapiens AGC_PRKCI_HUMAN AGC 1.2e-95 325.5 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKG1 KGP1_HUMAN 6BG2A Q13976 336 671 671.0 ANP:700 ATPlike Active DFGin 5.811 14.714 BLAminus -124.15, 169.14 66.07, 88.5 -100.57, 30.98 280.35, 66.41 -65.35, -25.12 in-in in 9.522 Saltbr-in 2.883 HRD-in -85.83, -52.95 73.29, 9.38 in-in-in SNCiii in-in ActLoopNT-in 2.851 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.93, 165.57 APE9-dihe-na 117.74, 172.78 APE8-dihe-in -83.6, 129.51 APE8-rot-in 307.46 APE67-dihe-in -66.9, -19.23 -49.63, -41.3 APE12-dist-in 8.235 APE11-dist-in 11.512 APE10-dist-in 6.041 APE9-dist-in 4.269 None TPO517 TPO517 XRAY 1.83 0.188 0.215 A 347 336 0 0 0 0 [[360, 619]] 1.0 6bg2 Homo sapiens AGC_PRKG1_HUMAN AGC 2.6e-84 288.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 6BG2B Q13976 346 671 671.0 ANP:700 ATPlike Active DFGin 6.001 13.81 BLAminus -122.67, 175.58 65.94, 84.43 -99.77, 30.78 285.96, 70.42 -64.93, -24.07 in-in in 8.944 Saltbr-in 2.743 HRD-in -86.95, -52.47 73.99, 7.96 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.61, 163.67 APE9-dihe-na 118.96, 172.39 APE8-dihe-in -86.94, 131.94 APE8-rot-in 306.51 APE67-dihe-in -68.79, -20.88 -48.58, -41.68 APE12-dist-in 7.826 APE11-dist-in 11.215 APE10-dist-in 5.769 APE9-dist-in 4.008 None TPO517 TPO517 XRAY 1.83 0.188 0.215 B 347 326 0 0 0 0 [[360, 619]] 1.0 6bg2 Homo sapiens AGC_PRKG1_HUMAN AGC 2.6e-84 288.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 6BG2C Q13976 337 671 671.0 ANP:700 ATPlike Active DFGin 5.746 14.057 BLAminus -122.99, 175.03 65.66, 84.22 -99.61, 30.7 281.62, 66.26 -64.81, -23.57 in-in in 8.742 Saltbr-in 2.723 HRD-in -85.99, -53.51 74.31, 7.4 in-in-in SNCiii in-in ActLoopNT-in 2.951 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.66, 165.85 APE9-dihe-na 118.46, 173.18 APE8-dihe-in -87.41, 130.75 APE8-rot-in 306.63 APE67-dihe-in -67.71, -19.03 -48.39, -42.55 APE12-dist-in 7.972 APE11-dist-in 11.385 APE10-dist-in 5.857 APE9-dist-in 3.861 None TPO517 TPO517 XRAY 1.83 0.188 0.215 C 347 335 0 0 0 0 [[360, 619]] 1.0 6bg2 Homo sapiens AGC_PRKG1_HUMAN AGC 2.6e-84 288.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 6BG2D Q13976 344 671 671.0 ANP:700 ATPlike Active DFGin 5.71 14.012 BLAminus -124.49, 174.79 65.67, 84.87 -99.37, 30.45 283.38, 66.11 -64.13, -22.3 in-in in 8.754 Saltbr-in 2.644 HRD-in -85.68, -52.69 74.16, 8.99 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.92, 166.42 APE9-dihe-na 119.53, 169.97 APE8-dihe-in -84.81, 130.45 APE8-rot-in 305.19 APE67-dihe-in -66.29, -19.88 -48.13, -43.31 APE12-dist-in 7.988 APE11-dist-in 11.327 APE10-dist-in 5.784 APE9-dist-in 3.81 None TPO517 TPO517 XRAY 1.83 0.188 0.215 D 347 328 0 0 0 0 [[360, 619]] 1.0 6bg2 Homo sapiens AGC_PRKG1_HUMAN AGC 2.6e-84 288.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7LV3A Q13976 57 671 671.0 ANP:60803 ATPlike Active DFGin 5.851 14.036 BLAminus -116.97, 177.04 63.26, 88.72 -106.87, 28.72 283.22, 63.7 -62.95, -24.33 in-in in 8.624 Saltbr-in 2.891 HRD-in -87.82, -54.22 74.26, 7.32 in-in-in SNCiii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.28, 149.98 APE9-dihe-na 157.95, -145.59 APE8-dihe-in -124.73, 128.61 APE8-rot-in 299.79 APE67-dihe-in -58.37, -20.06 -47.89, -51.97 APE12-dist-in 7.972 APE11-dist-in 11.057 APE10-dist-in 5.469 APE9-dist-in 3.811 None TPO517 TPO517 XRAY 2.41 0.201 0.238 A 617 600 0 0 0 0 [[360, 619]] 1.0 7lv3 Homo sapiens AGC_PRKG1_HUMAN AGC 1.3e-83 286.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7LV3B Q13976 58 671 671.0 ANP:60803 ATPlike Active DFGin 5.634 13.962 BLAminus -116.52, 178.28 63.3, 90.17 -108.68, 29.08 283.48, 65.02 -62.88, -23.93 in-in in 8.883 Saltbr-in 2.824 HRD-in -86.48, -52.9 74.97, 7.4 in-in-in SNCiii in-in ActLoopNT-in 2.959 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.28, 149.21 APE9-dihe-na 157.62, -145.94 APE8-dihe-in -123.75, 129.22 APE8-rot-in 300.73 APE67-dihe-in -59.05, -19.44 -46.41, -52.49 APE12-dist-in 8.134 APE11-dist-in 11.198 APE10-dist-in 5.604 APE9-dist-in 3.787 None TPO517 TPO517 XRAY 2.41 0.201 0.238 B 617 593 0 0 0 0 [[360, 619]] 1.0 7lv3 Homo sapiens AGC_PRKG1_HUMAN AGC 1.3e-83 286.3 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC ROCK1 ROCK1_HUMAN 2V55A Q13464 6 404 1354.0 ANP:1480 ATPlike Active DFGin 5.88 13.604 BLAminus -137.29, -177.31 60.22, 109.9 -132.74, 24.25 290.89, 71.12 -53.92, -52.21 in-in in 9.076 Saltbr-in 2.708 HRD-in -79.75, -71.28 93.49, -31.37 in-in-in SNCiii in-in ActLoopNT-in 3.281 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.46, 139.75 APE9-dihe-na 103.51, 160.5 APE8-dihe-in -55.22, 144.8 APE8-rot-in 285.63 APE67-dihe-in -74.86, -38.79 -80.34, -13.24 APE12-dist-in 10.324 APE11-dist-in 11.278 APE10-dist-in 5.647 APE9-dist-in 4.131 None None None XRAY 3.705 0.238 0.269 A 406 393 0 0 0 0 [[76, 338]] 1.0 2v55 Homo sapiens AGC_ROCK1_HUMAN AGC 3.3e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 2V55C Q13464 6 404 1354.0 ANP:1480 ATPlike Active DFGin 5.884 13.608 BLAminus -137.56, -177.44 62.15, 108.48 -130.26, 22.71 291.3, 72.92 -54.95, -50.69 in-in in 9.111 Saltbr-in 2.706 HRD-in -78.29, -71.79 95.11, -31.46 in-in-in SNCiii in-in ActLoopNT-in 3.247 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.41, 139.12 APE9-dihe-na 103.28, 159.31 APE8-dihe-in -53.48, 142.5 APE8-rot-in 287.35 APE67-dihe-in -76.24, -37.92 -78.8, -11.99 APE12-dist-in 10.28 APE11-dist-in 11.269 APE10-dist-in 5.623 APE9-dist-in 4.097 None None None XRAY 3.705 0.238 0.269 C 406 396 0 0 0 0 [[76, 338]] 1.0 2v55 Homo sapiens AGC_ROCK1_HUMAN AGC 3.3e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC RPS6KA1-1 KS6A1_HUMAN 8XOVA Q15418 56 340 735.0 ANP:401 ATPlike Inactive DFGin 9.532 13.12 BLAplus -128.25, 170.81 61.53, 44.51 -100.37, -14.37 34.15, 82.03 -83.22, -24.55 out-out out 11.134 Saltbr-out 8.897 HRD-in -75.5, -43.57 69.32, -59.52 out-out-out SNCooo out-out ActLoopNT-out 9.509 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioo APE10-dihe-na -98.67, 154.58 APE9-dihe-na -175.48, 178.84 APE8-dihe-in -87.06, 119.03 APE8-rot-in 310.44 APE67-dihe-in -48.48, -27.39 -73.46, -38.49 APE12-dist-none 999.0 APE11-dist-in 10.42 APE10-dist-out 11.512 APE9-dist-out 7.639 None None None XRAY 2.55 0.206 0.252 A 321 261 24 0 0 9 [[62, 321], [418, 675]] 2.0 8xov Homo sapiens AGC_RPS6KA1-1_HUMAN AGC 1.5e-95 325.1 1 260 260 204 205 206 208 210 94 112 116 184 186 185 187 244 232 227 226 225 224 223 222 221 142 Ribosomal protein S6 kinase alpha-1
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOA P51812 45 348 740.0 ANP:401 ATPlike Inactive DFGin 5.64 11.283 None -75.51, -9.72 -147.12, 169.74 -135.13, 44.64 43.61, 79.33 88.97, 14.8 none-none none 999.0 Saltbr-none 999.0 HRD-in -69.31, -36.27 72.22, -63.18 none-out-out SNCnoo out-out ActLoopNT-out 10.019 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.25 APE8-rot-out 57.51 APE67-dihe-in -58.48, -32.95 -79.53, -17.69 APE12-dist-out 16.181 APE11-dist-out 18.834 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 A 317 295 9 0 0 2 [[68, 327], [422, 679]] 2.0 7opo Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOE P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGin 5.828 11.217 None -75.62, -9.94 -146.57, 168.73 -137.15, 44.22 42.0, 80.75 88.39, 15.03 none-none none 999.0 Saltbr-none 999.0 HRD-in -66.39, -31.42 74.68, -62.95 none-out-out SNCnoo out-out ActLoopNT-out 10.132 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 163.55 APE8-rot-out 177.27 APE67-dihe-in -61.67, -34.26 -80.52, -22.56 APE12-dist-out 16.151 APE11-dist-out 17.693 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 E 317 293 10 0 0 2 [[68, 327], [422, 679]] 2.0 7opo Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOI P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGin 5.742 11.315 None -74.55, -8.16 -143.05, 166.95 -136.59, 41.95 46.16, 81.46 88.21, 13.52 none-none none 999.0 Saltbr-none 999.0 HRD-in -66.43, -31.99 74.45, -63.8 none-out-out SNCnoo out-out ActLoopNT-out 10.224 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_onnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 118.34 APE8-rot-out 174.05 APE67-dihe-in -60.03, -34.02 -108.65, -14.12 APE12-dist-out 16.688 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 I 317 292 11 0 0 3 [[68, 327], [422, 679]] 2.0 7opo Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOK P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGin 5.743 11.055 None -76.12, -10.81 -146.65, 168.53 -136.2, 45.6 41.69, 77.26 88.29, 15.08 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.92, -32.34 73.01, -61.24 none-out-out SNCnoo out-out ActLoopNT-out 9.952 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 7.45 APE8-rot-out 57.97 APE67-dihe-in -59.53, -34.14 -77.79, -20.27 APE12-dist-out 17.117 APE11-dist-out 17.377 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 K 317 293 10 0 0 2 [[68, 327], [422, 679]] 2.0 7opo Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOC P51812 46 347 740.0 ANP:401 ATPlike Inactive DFGinter 5.815 10.993 None -75.13, -10.43 -146.35, 169.25 -135.79, 44.23 43.29, 81.79 87.07, 14.29 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.74, -32.6 74.07, -63.87 none-out-out SNCnoo out-out ActLoopNT-out 10.165 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -61.13, 122.89 APE9-dihe-na 75.62, 166.95 APE8-dihe-in -113.03, 115.92 APE8-rot-out 46.3 APE67-dihe-in -62.7, -36.2 -57.15, -32.55 APE12-dist-out 16.312 APE11-dist-out 16.934 APE10-dist-out 13.494 APE9-dist-out 6.87 None None None XRAY 2.75 0.209 0.232 C 317 295 7 0 0 0 [[68, 327], [422, 679]] 2.0 7opo Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOG P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGinter 6.68 10.963 None -75.68, -10.29 -146.32, 168.68 -137.91, 45.72 44.25, 84.07 86.95, 15.93 out-out out 19.338 Saltbr-out 19.753 HRD-in -66.3, -31.74 74.35, -64.56 out-out-out SNCooo out-out ActLoopNT-out 10.112 ActLoopCT-out nonTYR APEdihe_aanni APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 105.02 APE8-rot-none 999.0 APE67-dihe-in -58.75, -33.49 -86.55, -15.46 APE12-dist-out 16.986 APE11-dist-out 17.767 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 G 317 301 2 0 0 2 [[68, 327], [422, 679]] 2.0 7opo Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.4e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA6-1 KS6A6_HUMAN 6G77A Q9UK32 51 349 745.0 ANP:401,ANP:402 Allosteric,ATPlike Inactive DFGin 5.984 11.252 None -84.57, 1.64 -160.36, 173.95 -140.73, 41.08 33.77, 88.9 86.89, 20.77 none-none none 999.0 Saltbr-none 999.0 HRD-in -75.55, -32.96 78.36, -52.1 none-out-out SNCnoo out-out ActLoopNT-out 9.958 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 55.72, -148.34 APE9-dihe-na -103.74, -158.66 APE8-dihe-in -91.11, 113.9 APE8-rot-in 297.76 APE67-dihe-in -53.19, -20.32 -55.54, -41.19 APE12-dist-in 13.732 APE11-dist-out 15.871 APE10-dist-out 13.504 APE9-dist-in 5.532 None None None XRAY 2.499 0.188 0.233 A 307 291 8 0 0 0 [[73, 330], [426, 683]] 2.0 6g77 Homo sapiens AGC_RPS6KA6-1_HUMAN AGC 1.1e-97 332.1 1 260 260 215 216 217 219 221 105 123 127 195 197 196 198 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G77B Q9UK32 51 349 745.0 ANP:401,ANP:402 Allosteric,ATPlike Inactive DFGin 5.612 11.311 None -84.74, -2.79 -145.41, 176.89 -143.69, 39.64 45.89, 82.52 94.84, 15.56 none-none none 999.0 Saltbr-none 999.0 HRD-in -77.95, -30.79 74.87, -47.1 none-out-out SNCnoo out-out ActLoopNT-out 10.071 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 55.75, -144.28 APE9-dihe-na -119.2, -153.74 APE8-dihe-in -83.74, 120.03 APE8-rot-in 297.54 APE67-dihe-in -52.98, -34.42 -57.71, -42.71 APE12-dist-in 13.915 APE11-dist-out 16.086 APE10-dist-out 13.633 APE9-dist-in 5.522 None None None XRAY 2.499 0.188 0.233 B 307 291 8 0 0 0 [[73, 330], [426, 683]] 2.0 6g77 Homo sapiens AGC_RPS6KA6-1_HUMAN AGC 1.1e-97 332.1 1 260 260 215 216 217 219 221 105 123 127 195 197 196 198 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G76B Q9UK32 51 349 745.0 ANP:401 ATPlike Inactive DFGinter 5.797 10.982 None -66.14, -24.76 -146.8, 171.15 -130.39, 64.5 31.65, 91.02 69.21, 34.12 none-none none 999.0 Saltbr-none 999.0 HRD-in -64.7, -28.83 65.1, -58.97 none-out-none SNCnon out-none ActLoopNT-out 9.714 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -65.75, -19.3 999.0, -17.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP232 SEP232 XRAY 3.0 0.226 0.268 B 307 269 30 0 0 11 [[73, 330], [426, 683]] 2.0 6g76 Homo sapiens AGC_RPS6KA6-1_HUMAN AGC 1.1e-97 332.1 1 260 260 215 216 217 219 221 105 123 127 195 197 196 198 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G78A Q9UK32 51 349 745.0 ANP:401 ATPlike Inactive DFGinter 6.269 10.634 None -86.41, -10.47 -141.48, -170.45 -156.88, 52.15 42.27, 88.32 84.48, 16.59 none-none none 999.0 Saltbr-none 999.0 HRD-in -69.26, -28.88 63.94, -61.25 none-out-out SNCnoo out-out ActLoopNT-out 9.59 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 82.23 APE8-dihe-out 57.69, 79.35 APE8-rot-in 324.77 APE67-dihe-in -47.93, -24.91 -65.59, -33.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 7.912 S232E None None XRAY 2.5 0.227 0.24 A 307 283 16 0 0 8 [[73, 330], [426, 683]] 2.0 6g78 Homo sapiens AGC_RPS6KA6-1_HUMAN AGC 1.4e-97 331.8 1 260 260 215 216 217 219 221 105 123 127 195 197 196 198 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G78B Q9UK32 51 349 745.0 ANP:401 ATPlike Inactive DFGinter 5.64 10.738 None -79.92, -10.17 -139.49, -179.53 -146.16, 53.91 40.8, 75.5 84.23, 17.04 none-none none 999.0 Saltbr-none 999.0 HRD-in -71.51, -26.87 55.09, -79.87 none-out-out SNCnoo out-out ActLoopNT-out 9.839 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -162.93 APE8-dihe-in -60.6, 118.59 APE8-rot-in 321.37 APE67-dihe-in -66.02, -21.47 -64.56, -33.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.845 S232E None None XRAY 2.5 0.227 0.24 B 307 281 18 0 0 10 [[73, 330], [426, 683]] 2.0 6g78 Homo sapiens AGC_RPS6KA6-1_HUMAN AGC 1.4e-97 331.8 1 260 260 215 216 217 219 221 105 123 127 195 197 196 198 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G76A Q9UK32 51 349 745.0 ANP:401,ANP:402 ATPlike,Allosteric Inactive DFGinter 6.261 10.877 None -85.39, -13.66 -143.61, 178.12 -143.21, 50.96 33.86, 88.85 75.03, 27.38 none-none none 999.0 Saltbr-none 999.0 HRD-in -70.26, -5.92 45.43, -59.01 none-out-out SNCnoo out-out ActLoopNT-out 9.842 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 52.64, -135.92 APE9-dihe-na -103.88, -148.96 APE8-dihe-in -100.12, 127.8 APE8-rot-in 306.8 APE67-dihe-in -56.57, -28.02 -70.04, -37.97 APE12-dist-in 13.909 APE11-dist-out 16.247 APE10-dist-out 12.746 APE9-dist-in 5.596 None SEP232 SEP232 XRAY 3.0 0.226 0.268 A 307 291 8 0 0 0 [[73, 330], [426, 683]] 2.0 6g76 Homo sapiens AGC_RPS6KA6-1_HUMAN AGC 1.1e-97 332.1 1 260 260 215 216 217 219 221 105 123 127 195 197 196 198 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC SGK1 SGK1_HUMAN 2R5TA O00141 82 378 431.0 ANP:500 ATPlike Inactive DFGinter 10.249 5.74 None -86.79, -16.14 -72.2, 135.26 -125.95, 20.0 58.26, 94.07 102.37, 6.12 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.44, -44.78 83.3, -51.0 none-out-out SNCnoo out-out ActLoopNT-out 9.243 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na 54.74, 50.94 APE9-dihe-na -69.27, 152.13 APE8-dihe-in -51.76, 128.99 APE8-rot-in 305.39 APE67-dihe-out -166.98, 160.95 -53.6, 132.16 APE12-dist-out 29.883 APE11-dist-out 30.65 APE10-dist-out 28.034 APE9-dist-out 16.248 S74A,S78A,S397A,S401A None None XRAY 1.9 0.193 0.215 A 373 284 13 0 0 0 [[98, 355]] 1.0 2r5t Homo sapiens AGC_SGK1_HUMAN AGC 4.6e-99 336.7 1 260 260 239 240 241 243 245 127 146 150 219 221 220 222 279 267 262 261 260 259 258 257 256 177 Serine/threonine-protein kinase Sgk1
AGC STK38 STK38_HUMAN 6BXIA Q15208 82 414 465.0 ANP:501 ATPlike Inactive DFGin 7.624 15.242 None -66.11, 165.54 -58.06, 132.91 -140.43, 160.91 66.01, 93.84 127.58, -39.07 out-out out 17.224 Saltbr-out 15.803 HRD-out -81.74, 95.52 -90.45, 26.47 out-out-out SNCooo out-out ActLoopNT-out 8.463 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -99.6, -60.62 APE9-dihe-na 67.05, -156.06 APE8-dihe-in -145.17, 163.6 APE8-rot-out 65.89 APE67-dihe-in -50.28, -35.19 -91.75, 25.88 APE12-dist-out 17.338 APE11-dist-out 14.208 APE10-dist-out 17.77 APE9-dist-out 12.101 None None None XRAY 2.2 0.173 0.212 A 333 333 0 0 0 0 [[89, 382]] 1.0 6bxi Homo sapiens AGC_STK38_HUMAN AGC 2.8e-98 334.1 1 260 260 229 230 231 233 235 118 137 141 209 211 210 212 304 292 287 286 285 284 283 282 281 167 Serine/threonine-protein kinase 38
AGC STK38 STK38_HUMAN 6BXIB Q15208 83 414 465.0 ANP:501 ATPlike Inactive DFGin 7.583 15.179 None -72.08, 165.13 -53.35, 130.13 -138.87, 159.98 66.77, 96.29 126.01, -39.3 out-out out 17.166 Saltbr-out 16.064 HRD-out -84.3, 107.68 -100.32, 27.31 out-out-out SNCooo out-out ActLoopNT-out 8.488 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -97.07, -63.08 APE9-dihe-na 73.07, -157.98 APE8-dihe-in -144.12, 160.82 APE8-rot-out 65.98 APE67-dihe-in -53.15, -35.39 -88.29, 27.93 APE12-dist-out 17.239 APE11-dist-out 14.184 APE10-dist-out 17.741 APE9-dist-out 12.052 None None None XRAY 2.2 0.173 0.212 B 333 332 0 0 0 0 [[89, 382]] 1.0 6bxi Homo sapiens AGC_STK38_HUMAN AGC 2.8e-98 334.1 1 260 260 229 230 231 233 235 118 137 141 209 211 210 212 304 292 287 286 285 284 283 282 281 167 Serine/threonine-protein kinase 38
CAMK AURKA AURKA_HUMAN 2DWBA O14965 126 389 403.0 ANP:502 ATPlike Inactive DFGin 5.605 15.114 BLAminus -136.11, 177.41 60.85, 78.38 -89.15, 29.26 286.88, 68.88 -66.25, -4.03 in-in in 9.24 Saltbr-in 3.169 HRD-in -70.6, -46.07 60.68, 4.1 in-in-out SNCiio in-out ActLoopNT-in 3.036 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -134.99, -178.03 APE9-dihe-na -132.27, -116.26 APE8-dihe-in -79.37, 134.9 APE8-rot-out 179.73 APE67-dihe-in -26.2, -44.84 -85.0, -15.78 APE12-dist-in 8.036 APE11-dist-in 12.139 APE10-dist-out 11.162 APE9-dist-out 10.827 None None MSE300,MSE305,MSE373 XRAY 2.5 0.227 0.275 A 285 262 2 0 0 2 [[133, 383]] 1.0 2dwb Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPGA O14965 7 389 403.0 ANP:60401 ATPlike Active DFGin 5.318 15.07 BLAminus -133.54, 176.05 56.91, 81.54 -90.61, 23.9 286.39, 75.22 -62.73, -9.76 in-in in 9.884 Saltbr-in 2.954 HRD-in -72.51, -51.0 67.55, 11.3 in-in-in SNCiii in-in ActLoopNT-in 3.043 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.96, 159.16 APE9-dihe-na 122.67, -152.53 APE8-dihe-in -117.94, 146.39 APE8-rot-in 309.68 APE67-dihe-in -61.83, -12.97 -52.19, -62.88 APE12-dist-in 8.517 APE11-dist-in 11.427 APE10-dist-in 5.724 APE9-dist-in 3.833 None TPO287,TPO288 TPO287,TPO288 XRAY 2.64 0.204 0.245 A 292 267 0 0 0 0 [[133, 383]] 1.0 6vpg Homo sapiens CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPIA O14965 104 389 403.0 ANP:60601 ATPlike Inactive DFGin 5.408 15.319 BLAminus -130.78, 176.39 58.02, 80.51 -93.54, 25.65 284.58, 75.71 -64.44, -24.62 in-in in 9.884 Saltbr-in 3.197 HRD-in -68.95, -50.99 70.99, 3.21 in-in-out SNCiio in-out ActLoopNT-in 2.821 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -142.04, 146.83 APE9-dihe-na 91.87, 167.2 APE8-dihe-in -74.18, 122.94 APE8-rot-in 319.25 APE67-dihe-in -55.59, -26.7 -100.93, -9.45 APE12-dist-in 10.01 APE11-dist-in 12.835 APE10-dist-out 16.149 APE9-dist-out 20.056 None None None XRAY 2.0 0.188 0.215 A 292 264 0 0 0 0 [[133, 383]] 1.0 6vpi Homo sapiens CAMK_AURKA_HUMAN CAMK 6.9e-78 267.5 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPLA O14965 7 389 403.0 ANP:60602,R7D:60606 ATPlike,Allosteric Inactive DFGin 5.471 15.702 BLAminus -128.47, 179.47 64.6, 81.81 -95.02, 21.48 283.88, 78.68 -63.38, -17.61 out-out out 10.41 Saltbr-out 4.499 HRD-in -80.46, -54.34 74.63, 5.06 out-in-out SNCoio in-out ActLoopNT-in 2.966 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -88.44, -6.25 APE9-dihe-na -62.06, -23.8 APE8-dihe-in -134.19, 108.37 APE8-rot-in 311.29 APE67-dihe-in -61.89, -28.27 -86.38, -9.29 APE12-dist-out 25.894 APE11-dist-out 21.325 APE10-dist-out 23.16 APE9-dist-out 28.004 None TPO288 TPO288 XRAY 1.86 0.169 0.201 A 292 261 4 0 0 4 [[133, 383]] 1.0 6vpl Homo sapiens CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPLB O14965 7 389 403.0 ANP:60601,R7D:60605 ATPlike,Allosteric Inactive DFGin 5.583 16.045 BLAminus -127.84, 176.75 65.51, 80.18 -93.8, 23.88 286.09, 77.69 -67.93, -15.19 out-out out 10.656 Saltbr-out 4.558 HRD-in -79.97, -52.06 71.02, 4.97 out-in-out SNCoio in-out ActLoopNT-in 2.944 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -84.27, -7.56 APE9-dihe-na -59.65, -24.89 APE8-dihe-in -135.15, 99.87 APE8-rot-in 315.26 APE67-dihe-in -58.26, -30.91 -76.18, -13.07 APE12-dist-out 25.859 APE11-dist-out 21.401 APE10-dist-out 23.563 APE9-dist-out 28.245 None TPO288 TPO288 XRAY 1.86 0.169 0.201 B 292 261 4 0 0 4 [[133, 383]] 1.0 6vpl Homo sapiens CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2C6DA O14965 126 390 403.0 ANP:61391 ATPlike Inactive DFGin 6.257 16.422 None -70.12, 150.14 -40.51, 101.21 -55.1, 131.85 61.77, 102.87 98.63, -164.78 out-out out 13.16 Saltbr-out 13.998 HRD-out -91.98, 166.93 -128.47, 87.17 out-out-out SNCooo out-out ActLoopNT-out 17.933 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 134.8 APE8-dihe-in -71.63, 167.98 APE8-rot-out 60.54 APE67-dihe-in -57.74, -18.95 -51.64, -36.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.044 None None None XRAY 2.2 0.23 0.28 A 275 255 10 0 0 10 [[133, 383]] 1.0 2c6d Homo sapiens CAMK_AURKA_HUMAN CAMK 1.5e-79 272.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPJA O14965 104 389 403.0 ANP:60401 ATPlike Inactive DFGout 12.87 10.574 None -110.21, 156.22 -91.65, 36.01 -66.52, 152.83 298.69, 154.8 77.13, 20.04 out-out out 11.11 Saltbr-out 9.286 HRD-out -138.11, 171.42 -106.7, -171.48 out-out-out SNCooo out-out ActLoopNT-out 12.659 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -97.02, 1.42 APE9-dihe-na 78.4, 140.83 APE8-dihe-out -96.06, -166.39 APE8-rot-out 60.44 APE67-dihe-in -59.33, -27.82 -96.84, 6.17 APE12-dist-in 11.648 APE11-dist-in 13.256 APE10-dist-out 10.911 APE9-dist-out 17.215 None None None XRAY 2.1 0.192 0.215 A 292 263 3 0 0 3 [[133, 383]] 1.0 6vpj Homo sapiens CAMK_AURKA_HUMAN CAMK 7.7e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6VPHA O14965 7 389 403.0 ANP:60604 ATPlike Inactive DFGout 13.671 11.556 None -98.71, -169.93 -135.39, 50.18 -66.9, 153.36 295.81, 141.3 65.48, 29.39 out-out out 11.379 Saltbr-out 9.775 HRD-out -105.53, 132.54 -112.81, 142.85 out-out-out SNCooo out-out ActLoopNT-out 14.58 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na -129.35, -34.6 APE9-dihe-na -51.22, -37.08 APE8-dihe-out -65.53, -18.81 APE8-rot-out 65.19 APE67-dihe-in -56.69, -28.96 -65.95, -34.72 APE12-dist-out 14.76 APE11-dist-in 9.582 APE10-dist-out 12.257 APE9-dist-out 21.222 None TPO287,TPO288 CAS247,TPO287,TPO288,CAS290 XRAY 2.14 0.189 0.216 A 292 267 0 0 0 0 [[133, 383]] 1.0 6vph Homo sapiens CAMK_AURKA_HUMAN CAMK 8.4e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK CASK CSKP_HUMAN 3MFRA O14936 5 306 926.0 ANP:500 ATPlike Pseudo DFGin 7.288 14.824 BLAminus -130.01, -163.55 44.45, 79.28 -92.76, 26.16 280.97, 75.37 -59.27, -25.64 in-in in 9.502 Saltbr-in 2.799 HRD-in -78.83, -45.71 73.64, -1.18 in-in-in SNCiii in-in ActLoopNT-in 2.998 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.41, 141.74 APE9-dihe-na 116.11, -155.43 APE8-dihe-in -114.21, 120.95 APE8-rot-in 305.84 APE67-dihe-in -66.35, -20.44 -39.68, -44.71 APE12-dist-in 11.987 APE11-dist-in 12.403 APE10-dist-in 6.658 APE9-dist-in 3.593 P22A,H145E,C146N,G162D None None XRAY 2.0 0.198 0.241 A 351 302 0 0 0 0 [[12, 276]] 1.0 3mfr Homo sapiens CAMK_CASK_HUMAN CAMK 2.4e-85 291.9 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3MFSA O14936 4 306 926.0 ANP:500 ATPlike Pseudo DFGin 7.121 14.917 BLAminus -132.54, -159.47 54.72, 71.28 -90.49, 27.88 285.64, 73.35 -63.01, -24.88 in-in in 9.855 Saltbr-in 3.256 HRD-in -74.69, -45.24 69.87, -1.37 in-in-in SNCiii in-in ActLoopNT-in 2.876 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.15, 142.33 APE9-dihe-na 119.56, -149.24 APE8-dihe-in -110.99, 115.07 APE8-rot-in 303.42 APE67-dihe-in -55.02, -32.56 -38.77, -44.89 APE12-dist-in 12.085 APE11-dist-in 12.3 APE10-dist-in 6.637 APE9-dist-in 3.634 P22A,H145E,C146N,G162D None None XRAY 2.1 0.221 0.268 A 351 303 0 0 0 0 [[12, 276]] 1.0 3mfs Homo sapiens CAMK_CASK_HUMAN CAMK 2.4e-85 291.9 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 3MFUA O14936 5 306 926.0 ANP:500 ATPlike Pseudo DFGin 7.162 14.979 BLAminus -132.46, -169.21 51.97, 75.16 -95.02, 30.45 283.47, 72.96 -64.45, -32.11 in-in in 9.439 Saltbr-in 3.206 HRD-in -76.17, -45.52 71.72, -5.88 in-in-in SNCiii in-in ActLoopNT-in 2.823 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.79, 142.93 APE9-dihe-na 117.49, -160.73 APE8-dihe-in -102.18, 121.4 APE8-rot-in 298.46 APE67-dihe-in -63.89, -19.89 -44.81, -44.73 APE12-dist-in 12.084 APE11-dist-in 12.195 APE10-dist-in 6.449 APE9-dist-in 3.737 P22A,H145E,C146N,G162D None None XRAY 2.3 0.182 0.234 A 351 302 0 0 0 0 [[12, 276]] 1.0 3mfu Homo sapiens CAMK_CASK_HUMAN CAMK 2.4e-85 291.9 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 9M6GA O14936 5 312 926.0 ANP:401 ATPlike Pseudo DFGin 7.452 15.114 BLAminus -123.77, -152.06 75.54, 37.97 -87.68, 22.87 280.47, 84.05 -71.57, -12.61 in-in in 9.6 Saltbr-in 2.897 HRD-in -79.25, -45.64 76.25, -8.72 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.23, 151.66 APE9-dihe-na 106.36, -155.68 APE8-dihe-in -120.97, 120.76 APE8-rot-in 297.98 APE67-dihe-in -62.79, -20.16 -47.6, -44.68 APE12-dist-in 12.42 APE11-dist-in 12.215 APE10-dist-in 6.65 APE9-dist-in 3.645 None None None XRAY 1.7 0.167 0.187 A 325 308 0 0 0 0 [[12, 276]] 1.0 9m6g Homo sapiens CAMK_CASK_HUMAN CAMK 4.9e-82 281.1 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CASK CSKP_HUMAN 9M5YA O14936 3 312 926.0 ANP:401 ATPlike Pseudo DFGin 7.714 15.512 BLAminus -121.67, -150.51 71.79, 35.46 -86.15, 22.59 279.83, 82.24 -67.65, -16.3 in-in in 9.959 Saltbr-in 2.867 HRD-in -79.78, -48.63 75.37, -2.97 in-in-in SNCiii in-in ActLoopNT-in 3.012 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.65, 147.9 APE9-dihe-na 109.7, -155.33 APE8-dihe-in -121.16, 120.88 APE8-rot-in 298.99 APE67-dihe-in -58.84, -21.41 -46.45, -46.8 APE12-dist-in 12.687 APE11-dist-in 12.279 APE10-dist-in 6.857 APE9-dist-in 3.592 None None None XRAY 1.8 0.168 0.197 A 338 310 0 0 0 0 [[12, 276]] 1.0 9m5y Homo sapiens CAMK_CASK_HUMAN CAMK 5.6e-82 280.9 1 256 256 161 162 163 165 167 41 62 66 138 140 139 141 201 189 184 183 182 181 180 179 178 92 Peripheral plasma membrane protein CASK
CAMK CHEK1 CHK1_HUMAN 5OOPA O14757 5 271 476.0 ANP:301 ATPlike Inactive DFGin 7.048 13.858 BLAminus -117.87, 168.06 78.81, 84.96 -99.9, 22.77 292.72, 82.66 -69.65, -23.48 in-out in 9.592 Saltbr-out 3.669 HRD-in -77.29, -47.33 77.92, -0.19 out-in-in SNCoii in-in ActLoopNT-in 2.894 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.46, 169.24 APE9-dihe-na 115.98, -146.93 APE8-dihe-in -135.24, 119.66 APE8-rot-in 302.63 APE67-dihe-in -65.46, -19.69 -46.47, -46.68 APE12-dist-in 8.889 APE11-dist-in 11.835 APE10-dist-in 6.194 APE9-dist-in 3.474 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.7 0.159 0.197 A 297 261 6 0 0 0 [[9, 265]] 1.0 5oop Homo sapiens CAMK_CHEK1_HUMAN CAMK 4.8e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK DAPK1 DAPK1_HUMAN 1IG1A P53355 2 294 1430.0 ANP:300 ATPlike Inactive DFGin 6.604 13.909 BLAminus -125.04, -172.1 54.91, 85.1 -99.27, 28.4 288.12, 76.24 -63.74, -23.2 in-in in 9.031 Saltbr-in 2.75 HRD-in -78.58, -44.7 65.96, 3.14 in-in-out SNCiio in-out ActLoopNT-in 2.921 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -151.68, 130.77 APE9-dihe-na -110.11, -140.22 APE8-dihe-in -82.02, 119.3 APE8-rot-in 301.63 APE67-dihe-in -57.96, -29.17 -38.12, -46.81 APE12-dist-in 11.797 APE11-dist-out 6.564 APE10-dist-out 9.413 APE9-dist-in 4.736 None None None XRAY 1.8 0.19 0.213 A 294 280 0 0 0 0 [[13, 275]] 1.0 1ig1 Homo sapiens CAMK_DAPK1_HUMAN CAMK 6.1e-95 323.3 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 1JKKA P53355 2 293 1430.0 ANP:300 ATPlike Inactive DFGin 6.784 14.124 BLAminus -129.05, -171.64 53.69, 79.96 -93.76, 28.82 285.99, 76.67 -62.99, -25.8 in-in in 9.083 Saltbr-in 2.852 HRD-in -75.07, -48.19 66.55, 3.19 in-in-out SNCiio in-out ActLoopNT-in 2.818 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -147.0, 130.95 APE9-dihe-na -112.64, -140.24 APE8-dihe-in -81.46, 116.94 APE8-rot-in 307.06 APE67-dihe-in -60.31, -32.99 -34.91, -46.77 APE12-dist-in 11.783 APE11-dist-out 6.58 APE10-dist-out 9.463 APE9-dist-in 4.776 None None None XRAY 2.4 0.204 0.239 A 294 277 0 0 0 0 [[13, 275]] 1.0 1jkk Homo sapiens CAMK_DAPK1_HUMAN CAMK 6.1e-95 323.3 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 1JKLA P53355 2 294 1430.0 ANP:300 ATPlike Inactive DFGin 6.695 14.057 BLAminus -124.2, -176.99 56.35, 84.0 -97.94, 28.61 287.61, 72.21 -64.45, -19.09 in-in in 9.138 Saltbr-in 2.734 HRD-in -79.78, -44.18 66.54, 4.23 in-in-out SNCiio in-out ActLoopNT-in 2.905 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -149.57, 122.41 APE9-dihe-na -98.92, -146.89 APE8-dihe-in -78.98, 121.07 APE8-rot-in 305.85 APE67-dihe-in -59.69, -24.46 -37.84, -49.7 APE12-dist-in 11.685 APE11-dist-out 6.593 APE10-dist-out 9.371 APE9-dist-in 4.342 None None None XRAY 1.62 0.201 0.218 A 294 280 0 0 0 0 [[13, 275]] 1.0 1jkl Homo sapiens CAMK_DAPK1_HUMAN CAMK 6.1e-95 323.3 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3EHAA P53355 2 277 1430.0 ANP:60001 ATPlike Inactive DFGin 6.643 13.968 BLAminus -119.49, -175.62 63.64, 76.35 -92.04, 24.1 287.15, 77.48 -66.02, -21.06 in-in in 9.158 Saltbr-in 2.692 HRD-in -77.77, -44.22 68.16, 6.09 in-in-out SNCiio in-out ActLoopNT-in 2.888 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -154.08, 109.66 APE9-dihe-na -88.11, -145.31 APE8-dihe-in -81.75, 125.02 APE8-rot-in 299.42 APE67-dihe-in -58.59, -25.21 -48.84, -41.78 APE12-dist-in 11.47 APE11-dist-out 6.085 APE10-dist-out 9.287 APE9-dist-in 4.222 None None None XRAY 1.6 0.18 0.21 A 294 275 1 0 0 0 [[13, 275]] 1.0 3eha Homo sapiens CAMK_DAPK1_HUMAN CAMK 6.1e-95 323.3 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3F5UA P53355 2 277 1430.0 ANP:60296 ATPlike Inactive DFGin 6.68 13.995 BLAminus -122.58, -175.66 63.1, 76.98 -89.92, 20.62 285.03, 75.31 -66.71, -20.92 in-in in 9.054 Saltbr-in 2.688 HRD-in -78.22, -44.99 68.31, 7.38 in-in-out SNCiio in-out ActLoopNT-in 2.898 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -161.85, 115.62 APE9-dihe-na -94.87, -137.37 APE8-dihe-in -88.11, 123.84 APE8-rot-in 295.48 APE67-dihe-in -54.81, -31.05 -45.75, -45.06 APE12-dist-in 11.55 APE11-dist-out 6.151 APE10-dist-out 9.358 APE9-dist-in 4.63 None None None XRAY 2.0 0.18 0.245 A 295 276 0 0 0 0 [[13, 275]] 1.0 3f5u Homo sapiens CAMK_DAPK1_HUMAN CAMK 6.2e-95 323.3 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3DFCB P53355 2 277 1430.0 ANP:60296 ATPlike Inactive DFGin 6.707 13.953 BLAminus -118.29, -174.34 63.43, 75.59 -92.23, 26.78 286.33, 80.12 -73.39, -15.17 in-in in 8.97 Saltbr-in 2.527 HRD-in -81.02, -45.28 68.61, 4.35 in-in-out SNCiio in-out ActLoopNT-in 2.938 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -159.6, 115.29 APE9-dihe-na -93.8, -150.98 APE8-dihe-in -71.52, 120.43 APE8-rot-in 314.5 APE67-dihe-in -56.35, -28.25 -48.91, -39.24 APE12-dist-in 10.0 APE11-dist-out 6.581 APE10-dist-out 9.299 APE9-dist-in 4.232 Q23K None None XRAY 1.9 0.168 0.23 B 295 276 0 0 0 0 [[13, 275]] 1.0 3dfc Homo sapiens CAMK_DAPK1_HUMAN CAMK 6.8e-95 323.2 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3GU4A P53355 2 277 1430.0 ANP:60296 ATPlike Inactive DFGin 6.686 14.203 BLAminus -120.75, -178.24 63.74, 79.48 -95.12, 25.33 287.4, 76.71 -69.42, -15.77 in-in in 9.154 Saltbr-in 2.755 HRD-in -78.17, -46.9 70.13, 2.93 in-in-out SNCiio in-out ActLoopNT-in 2.893 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -151.92, 117.7 APE9-dihe-na -90.42, -152.95 APE8-dihe-in -78.93, 125.78 APE8-rot-in 285.84 APE67-dihe-in -58.94, -26.13 -43.12, -44.76 APE12-dist-in 9.916 APE11-dist-out 6.699 APE10-dist-out 9.394 APE9-dist-in 4.146 Q23V None None XRAY 1.35 0.185 0.211 A 295 276 0 0 0 0 [[13, 275]] 1.0 3gu4 Homo sapiens CAMK_DAPK1_HUMAN CAMK 2.1e-94 321.5 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3GU5A P53355 2 277 1430.0 ANP:60297 ATPlike Inactive DFGin 6.595 14.036 BLAminus -118.63, -175.92 62.35, 83.7 -99.02, 25.46 285.84, 80.17 -66.36, -22.17 in-in in 9.075 Saltbr-in 2.707 HRD-in -79.55, -44.61 67.36, 6.25 in-in-out SNCiio in-out ActLoopNT-in 2.938 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -153.43, 114.75 APE9-dihe-na -95.21, -137.89 APE8-dihe-in -89.62, 125.79 APE8-rot-in 297.58 APE67-dihe-in -53.19, -29.37 -44.73, -43.47 APE12-dist-in 11.313 APE11-dist-out 6.28 APE10-dist-out 9.572 APE9-dist-in 4.755 Q23V None None XRAY 1.65 0.178 0.219 A 295 276 0 0 0 0 [[13, 275]] 1.0 3gu5 Homo sapiens CAMK_DAPK1_HUMAN CAMK 2.1e-94 321.5 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK MELK MELK_HUMAN 4BL1A Q14680 2 333 651.0 ANP:1000 ATPlike Inactive DFGin 6.338 13.935 ABAminus -114.35, -16.21 -125.02, 95.86 -105.85, 20.97 306.05, 72.32 -48.23, -28.35 in-in in 8.566 Saltbr-in 2.628 HRD-in -47.49, -61.71 83.33, 5.93 in-in-out SNCiio in-out ActLoopNT-in 3.099 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 125.09 APE8-rot-out 166.93 APE67-dihe-in -51.79, -28.37 -37.56, -42.24 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.184 0.26 A 347 312 20 0 0 14 [[11, 263]] 1.0 4bl1 Homo sapiens CAMK_MELK_HUMAN CAMK 1.1e-88 303.0 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK PIM1 PIM1_HUMAN 1YXTA P11309 33 306 313.0 ANP:322 ATPlike Active DFGin 6.029 14.245 BLAminus -131.81, 176.98 66.39, 83.69 -99.64, 19.64 287.53, 80.25 -65.72, -15.35 in-in in 8.309 Saltbr-in 2.894 HRD-na-A -67.95, -50.18 66.45, 4.68 in-in-in SNCiii in-in ActLoopNT-in 2.809 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.69, 12.99 APE9-dihe-na -80.03, -158.46 APE8-dihe-in -83.46, 121.7 APE8-rot-in 308.53 APE67-dihe-in -70.36, -3.81 -49.69, -52.76 APE12-dist-in 9.729 APE11-dist-in 8.665 APE10-dist-in 5.279 APE9-dist-in 3.805 None None None XRAY 2.0 0.183 0.216 A 293 274 0 0 0 0 [[38, 290]] 1.0 1yxt Homo sapiens CAMK_PIM1_HUMAN CAMK 3.2e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 1XR1A P11309 32 308 313.0 ANP:501 ATPlike Active DFGin 5.888 14.214 BLAminus -138.05, 176.98 59.78, 85.31 -96.55, 16.88 287.93, 82.19 -61.38, -7.19 in-in in 8.717 Saltbr-in 2.833 HRD-na-A -59.95, -51.82 71.23, 5.72 in-in-in SNCiii in-in ActLoopNT-in 2.752 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.05, 45.66 APE9-dihe-na -114.17, -171.15 APE8-dihe-in -64.11, 112.97 APE8-rot-in 299.41 APE67-dihe-in -49.28, -12.21 -42.84, -67.53 APE12-dist-in 9.608 APE11-dist-in 8.695 APE10-dist-in 5.522 APE9-dist-in 4.07 None None None XRAY 2.1 0.267 0.301 A 300 277 0 0 0 0 [[38, 290]] 1.0 1xr1 Homo sapiens CAMK_PIM1_HUMAN CAMK 3.4e-65 225.8 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 3A99A P11309 33 305 313.0 ANP:501 ATPlike Active DFGin 5.934 14.254 BLAminus -128.38, 171.59 60.85, 87.29 -96.61, 22.08 288.57, 75.78 -65.84, -9.23 in-in in 8.754 Saltbr-in 2.604 HRD-na-A -66.86, -47.45 66.12, 8.26 in-in-in SNCiii in-in ActLoopNT-in 2.889 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.19, 26.41 APE9-dihe-na -87.51, -159.07 APE8-dihe-in -85.64, 119.66 APE8-rot-in 305.41 APE67-dihe-in -70.7, -5.81 -56.65, -39.81 APE12-dist-in 9.612 APE11-dist-in 8.461 APE10-dist-in 5.29 APE9-dist-in 3.778 None None None XRAY 1.6 0.187 0.206 A 320 273 0 0 0 0 [[38, 290]] 1.0 3a99 Homo sapiens CAMK_PIM1_HUMAN CAMK 4.3e-65 225.5 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 2BZKB P11309 33 305 313.0 ANP:1306 ATPlike Active DFGin 6.126 14.443 BLAminus -123.86, 174.78 64.57, 79.13 -87.5, 17.23 286.98, 86.61 -67.5, -17.62 in-in in 8.781 Saltbr-in 2.727 HRD-na-A -70.49, -48.81 68.36, 6.4 in-in-in SNCiii in-in ActLoopNT-in 2.813 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.63, 10.91 APE9-dihe-na -77.79, -156.22 APE8-dihe-in -90.85, 124.06 APE8-rot-in 315.85 APE67-dihe-in -68.94, -10.63 -60.69, -42.64 APE12-dist-in 9.464 APE11-dist-in 8.478 APE10-dist-in 4.851 APE9-dist-in 3.782 R250G None None XRAY 2.45 0.191 0.225 B 313 268 5 0 0 0 [[38, 290]] 1.0 2bzk Homo sapiens CAMK_PIM1_HUMAN CAMK 1.5e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PLK1 PLK1_HUMAN 8X72A P53350 37 330 603.0 ANP:401 ATPlike Inactive DFGin 5.674 14.562 BLAminus -124.66, -175.79 56.01, 84.34 -93.5, 28.11 290.48, 83.55 -67.08, -22.62 out-in out 10.036 Saltbr-in 3.369 HRD-in -69.02, -52.36 73.21, 2.03 in-in-out SNCiio in-out ActLoopNT-in 2.995 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -79.36, 95.87 APE9-dihe-na 140.51, 168.33 APE8-dihe-in -120.38, 96.0 APE8-rot-in 313.63 APE67-dihe-out -71.46, -55.88 -64.61, 149.56 APE12-dist-in 10.85 APE11-dist-out 7.455 APE10-dist-in 7.653 APE9-dist-out 8.043 None None None XRAY 2.2 0.198 0.25 A 333 294 0 0 0 0 [[53, 305]] 1.0 8x72 Homo sapiens CAMK_PLK1_HUMAN CAMK 1.7e-78 269.4 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
CAMK PLK1 PLK1_HUMAN 2OU7A P53350 37 328 603.0 ANP:500 ATPlike Inactive DFGin 5.511 14.626 BLAminus -126.46, 177.9 64.03, 83.89 -94.43, 31.27 293.9, 81.92 -69.65, -29.63 out-in out 10.018 Saltbr-in 3.599 HRD-in -73.43, -50.53 79.22, -6.25 in-in-out SNCiio in-out ActLoopNT-in 2.959 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_ioio APE10-dihe-na -86.17, 94.2 APE9-dihe-na 146.34, 174.25 APE8-dihe-in -131.14, 97.57 APE8-rot-in 299.54 APE67-dihe-out -68.04, -58.6 -56.03, 146.92 APE12-dist-in 10.381 APE11-dist-out 7.186 APE10-dist-in 7.436 APE9-dist-out 8.241 T210V None None XRAY 2.4 0.205 0.235 A 335 292 0 0 0 0 [[53, 305]] 1.0 2ou7 Homo sapiens CAMK_PLK1_HUMAN CAMK 1.8e-78 269.4 1 256 256 193 194 195 197 199 82 101 105 173 175 174 176 233 221 216 215 214 213 212 211 210 131 Serine/threonine-protein kinase PLK1
CAMK PLK4 PLK4_HUMAN 3COKA O00444 2 266 970.0 ANP:60301 ATPlike Inactive DFGin 6.144 15.397 BLAminus -124.31, 169.68 62.14, 91.45 -100.82, 17.44 292.06, 88.73 -56.38, -36.52 in-out in 9.768 Saltbr-out 4.569 HRD-out -88.33, 122.35 -44.77, 114.93 out-in-none SNCoin in-none ActLoopNT-in 2.788 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.25 0.211 0.261 A 278 232 33 0 0 19 [[12, 265]] 1.0 3cok Homo sapiens CAMK_PLK4_HUMAN CAMK 4.8e-82 281.0 1 256 256 153 154 155 157 159 41 60 64 133 135 134 136 193 181 176 175 174 173 172 171 170 90 Serine/threonine-protein kinase PLK4
CAMK PLK4 PLK4_HUMAN 3COKB O00444 2 266 970.0 ANP:60301 ATPlike Inactive DFGin 5.915 15.333 BLAminus -133.97, 164.53 62.63, 97.48 -104.66, 14.21 301.0, 88.72 -54.53, -38.93 in-out in 9.804 Saltbr-out 7.178 HRD-out -90.24, 129.56 -55.53, 110.17 out-in-none SNCoin in-none ActLoopNT-in 2.834 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.25 0.211 0.261 B 278 232 33 0 0 19 [[12, 265]] 1.0 3cok Homo sapiens CAMK_PLK4_HUMAN CAMK 4.8e-82 281.0 1 256 256 153 154 155 157 159 41 60 64 133 135 134 136 193 181 176 175 174 173 172 171 170 90 Serine/threonine-protein kinase PLK4
CAMK RPS6KA5-2 KS6A5_HUMAN 3KN5A O75582 415 729 802.0 ANP:400 ATPlike None DFGin 5.469 14.143 BLAminus -120.9, 173.77 65.89, 86.51 -96.46, 22.04 287.59, 69.84 -51.57, -39.89 in-in in 8.867 Saltbr-in 2.809 HRD-in -86.24, -52.51 73.21, 10.94 in-in-none SNCiin in-none ActLoopNT-in 2.989 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.211 0.278 A 325 282 33 0 0 18 [[49, 318], [423, 687]] 2.0 3kn5 Homo sapiens CAMK_RPS6KA5-2_HUMAN CAMK 2.1e-87 298.7 5 256 252 564 565 566 568 570 455 468 472 541 543 542 544 604 592 587 586 585 584 583 582 581 499 Ribosomal protein S6 kinase alpha-5
CAMK RPS6KA5-2 KS6A5_HUMAN 3KN5B O75582 415 729 802.0 ANP:400 ATPlike None DFGin 5.769 14.211 BLAminus -127.01, 177.83 61.12, 80.37 -96.03, 24.29 287.04, 69.05 -65.01, -20.75 in-in in 8.872 Saltbr-in 2.738 HRD-in -80.02, -49.37 72.67, 1.66 in-in-none SNCiin in-none ActLoopNT-in 2.867 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.211 0.278 B 325 289 26 0 0 18 [[49, 318], [423, 687]] 2.0 3kn5 Homo sapiens CAMK_RPS6KA5-2_HUMAN CAMK 2.1e-87 298.7 5 256 252 564 565 566 568 570 455 468 472 541 543 542 544 604 592 587 586 585 584 583 582 581 499 Ribosomal protein S6 kinase alpha-5
CAMK STK11 STK11_HUMAN 2WTKC Q15831 47 342 433.0 ANP:2 ATPlike Active DFGin 6.192 13.745 BLAminus -119.65, -175.81 55.97, 66.27 -90.3, 25.87 311.18, 25.77 -80.53, -8.11 in-in in 9.443 Saltbr-in 3.361 HRD-in -68.47, -42.92 70.9, -7.9 in-in-in SNCiii in-in ActLoopNT-in 2.648 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na 69.85, 15.07 APE9-dihe-na -72.04, -171.91 APE8-dihe-in -90.01, 115.78 APE8-rot-in 306.68 APE67-dihe-in -55.63, -13.05 -36.08, -60.58 APE12-dist-in 7.784 APE11-dist-in 9.233 APE10-dist-in 5.395 APE9-dist-in 3.173 D194A None None XRAY 2.65 0.24 0.291 C 305 285 3 0 0 0 [[49, 309]] 1.0 2wtk Homo sapiens CAMK_STK11_HUMAN CAMK 7.7e-66 228.0 1 256 256 193 194 195 197 199 78 98 102 173 175 174 176 237 223 218 217 216 215 214 213 212 130 Serine/threonine-protein kinase STK11
CAMK STK11 STK11_HUMAN 2WTKF Q15831 45 340 433.0 ANP:4 ATPlike Active DFGin 5.938 13.841 BLAminus -119.11, -173.26 54.53, 62.76 -80.33, 19.16 295.83, 69.09 -48.31, -46.43 in-in in 9.483 Saltbr-in 3.568 HRD-in -68.65, -42.45 72.6, -14.65 in-in-in SNCiii in-in ActLoopNT-in 2.922 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na 45.91, 2.58 APE9-dihe-na -73.83, 178.68 APE8-dihe-in -66.98, 134.68 APE8-rot-in 293.57 APE67-dihe-in -65.1, -33.79 -54.08, -45.39 APE12-dist-in 8.609 APE11-dist-in 9.659 APE10-dist-in 5.793 APE9-dist-in 3.313 D194A None None XRAY 2.65 0.24 0.291 F 305 268 16 0 0 0 [[49, 309]] 1.0 2wtk Homo sapiens CAMK_STK11_HUMAN CAMK 7.7e-66 228.0 1 256 256 193 194 195 197 199 78 98 102 173 175 174 176 237 223 218 217 216 215 214 213 212 130 Serine/threonine-protein kinase STK11
CK1 VRK1 VRK1_HUMAN 6AC9A Q99986 21 342 396.0 ANP:401 ATPlike Inactive DFGin 7.921 14.706 BLAminus -114.21, 177.93 70.15, 93.84 -115.1, 19.79 299.42, 81.98 -60.26, -28.75 in-in in 7.95 Saltbr-in 2.779 HRD-in -85.24, -47.15 69.74, 5.52 in-in-out SNCiio in-out ActLoopNT-in 2.799 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -132.17, 15.24 APE9-dihe-na 79.52, -153.87 APE8-dihe-in -97.68, 119.65 APE8-rot-in 299.88 APE67-dihe-in -62.87, -27.26 -44.77, -50.87 APE12-dist-in 9.478 APE11-dist-out 5.963 APE10-dist-out 10.714 APE9-dist-in 3.851 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.07 0.187 0.223 A 370 317 5 0 0 0 [[37, 326]] 1.0 6ac9 Homo sapiens CK1_VRK1_HUMAN CK1 8.9e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 6AC9B Q99986 21 341 396.0 ANP:401 ATPlike Inactive DFGin 7.916 14.739 BLAminus -115.54, 178.38 75.12, 91.43 -115.59, 17.29 297.69, 88.6 -57.57, -34.6 in-in in 8.093 Saltbr-in 2.77 HRD-in -83.61, -50.49 74.28, -0.88 in-in-out SNCiio in-out ActLoopNT-in 2.793 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -114.62, 8.0 APE9-dihe-na 78.71, -152.8 APE8-dihe-in -103.98, 122.42 APE8-rot-in 297.61 APE67-dihe-in -64.96, -28.03 -44.02, -51.48 APE12-dist-in 9.99 APE11-dist-out 5.433 APE10-dist-out 10.749 APE9-dist-in 3.727 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.07 0.187 0.223 B 370 316 5 0 0 0 [[37, 326]] 1.0 6ac9 Homo sapiens CK1_VRK1_HUMAN CK1 8.9e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 6AC9C Q99986 24 341 396.0 ANP:402 ATPlike Inactive DFGin 7.927 14.325 BLAminus -121.92, 176.09 69.3, 88.62 -104.37, 22.99 293.32, 87.67 -64.92, -32.52 in-in in 7.605 Saltbr-in 2.793 HRD-in -88.58, -46.78 72.09, 4.58 in-in-out SNCiio in-out ActLoopNT-in 2.856 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -67.72, 154.65 APE9-dihe-na 94.16, -162.22 APE8-dihe-in -91.17, 117.25 APE8-rot-in 299.96 APE67-dihe-in -65.18, -24.09 -48.81, -46.56 APE12-dist-out 14.966 APE11-dist-in 13.64 APE10-dist-in 7.925 APE9-dist-in 4.153 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.07 0.187 0.223 C 370 307 11 0 0 0 [[37, 326]] 1.0 6ac9 Homo sapiens CK1_VRK1_HUMAN CK1 8.9e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CK1 VRK1 VRK1_HUMAN 6AC9D Q99986 23 341 396.0 ANP:402 ATPlike Inactive DFGin 7.739 14.33 BLAminus -116.24, 179.23 65.24, 86.32 -103.3, 26.16 293.03, 86.03 -64.75, -25.98 in-in in 7.722 Saltbr-in 2.797 HRD-in -87.33, -42.3 69.45, 1.55 in-in-out SNCiio in-out ActLoopNT-in 2.992 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -66.0, 154.0 APE9-dihe-na 92.71, -167.74 APE8-dihe-in -86.89, 111.15 APE8-rot-in 299.25 APE67-dihe-in -66.58, -28.49 -43.2, -46.61 APE12-dist-out 14.83 APE11-dist-in 13.447 APE10-dist-in 7.737 APE9-dist-in 4.26 K34A,K35A,E36A,E212A,K214A,E215A,E292A,K293A,K295A,K359A,K360A None None XRAY 2.07 0.187 0.223 D 370 306 13 0 0 0 [[37, 326]] 1.0 6ac9 Homo sapiens CK1_VRK1_HUMAN CK1 8.9e-105 355.8 1 261 261 196 197 198 200 202 71 83 87 174 176 175 177 243 231 226 225 224 223 222 221 220 132 Serine/threonine-protein kinase VRK1
CMGC CDK1 CDK1_HUMAN 9SKQA P06493 3 288 297.0 ANP:60301 ATPlike Inactive DFGin 7.143 16.032 BLAminus -125.06, -177.1 57.55, 62.82 -86.84, 50.52 271.32, 82.93 -98.1, -26.9 in-out in 9.716 Saltbr-out 5.762 HRD-in -83.48, -58.42 64.77, 13.47 out-in-out SNCoio in-out ActLoopNT-in 2.685 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iiii APE10-dihe-na -142.74, 165.15 APE9-dihe-na 69.23, -36.98 APE8-dihe-out 60.52, 63.14 APE8-rot-out 73.99 APE67-dihe-out 57.27, -80.66 61.32, -166.6 APE12-dist-in 12.703 APE11-dist-in 10.027 APE10-dist-in 7.071 APE9-dist-in 3.731 None TPO161 TPO161 EM 3.4 999.0 999.0 A 302 286 0 0 0 0 [[4, 287]] 1.0 9skq Homo sapiens CMGC_CDK1_HUMAN CMGC 2.7e-87 298.9 1 301 301 145 146 147 149 151 33 51 55 125 127 126 128 186 173 168 167 166 165 164 163 162 81 Cyclin-dependent kinase 1
CMGC CDK12 CDK12_HUMAN 4CXAA Q9NYV4 718 1050 1490.0 ANP:2051 ATPlike Inactive DFGin 6.436 15.022 BLAminus -127.47, 178.63 59.83, 84.78 -103.34, 39.58 291.64, 72.71 -78.99, -14.54 in-in in 8.178 Saltbr-in 2.513 HRD-in -89.68, -50.66 63.81, 17.68 in-in-out SNCiio in-out ActLoopNT-in 2.793 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -113.43, 159.2 APE9-dihe-na 63.92, 139.76 APE8-dihe-in -56.37, 145.01 APE8-rot-out 63.76 APE67-dihe-in -64.68, -22.99 -55.23, -40.79 APE12-dist-in 13.212 APE11-dist-in 11.662 APE10-dist-in 7.363 APE9-dist-in 3.506 None TPO893 TPO893 XRAY 3.15 0.224 0.279 A 340 330 3 0 0 1 [[727, 1020]] 1.0 4cxa Homo sapiens CMGC_CDK12_HUMAN CMGC 2.6e-84 289.0 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK2 CDK2_HUMAN 9QCVK P24941 1 292 298.0 ANP:60301 ATPlike Inactive DFGin 6.495 15.807 BLAminus -144.96, -178.89 57.85, 64.57 -85.72, 49.93 282.03, 73.0 -84.65, -33.03 in-out in 9.3 Saltbr-out 4.618 HRD-in -70.41, -54.19 69.05, 2.44 out-in-out SNCoio in-out ActLoopNT-in 2.576 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -164.79, 153.04 APE9-dihe-na -68.87, 164.19 APE8-dihe-in -61.62, 153.89 APE8-rot-out 41.16 APE67-dihe-in -67.77, -23.98 -60.52, -33.7 APE12-dist-in 11.155 APE11-dist-out 6.112 APE10-dist-out 8.897 APE9-dist-in 4.078 None None None EM 2.5 999.0 999.0 K 301 292 0 0 0 0 [[4, 286]] 1.0 9qcv Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK7 CDK7_HUMAN 8R99A P50613 10 311 346.0 ANP:401 ATPlike Inactive DFGin 6.921 15.074 BLAminus -136.18, 178.53 62.42, 80.05 -92.8, 32.41 285.07, 70.02 -64.17, -34.45 in-out in 9.457 Saltbr-out 5.606 HRD-in -70.53, -54.5 69.94, 6.7 out-in-out SNCoio in-out ActLoopNT-in 2.711 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -115.64, 148.75 APE9-dihe-na -60.57, 161.29 APE8-dihe-in -48.68, 142.11 APE8-rot-out 161.53 APE67-dihe-in -67.83, -20.09 -55.43, -38.94 APE12-dist-in 10.449 APE11-dist-out 5.162 APE10-dist-out 9.448 APE9-dist-in 3.715 W132R,S164D,T170E None None XRAY 1.81 0.178 0.22 A 371 283 19 0 0 0 [[12, 295]] 1.0 8r99 Homo sapiens CMGC_CDK7_HUMAN CMGC 7.3e-78 269.6 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 9QCVJ P50613 10 346 346.0 ANP:60401 ATPlike Inactive DFGin 6.812 15.58 BLAminus -138.8, -173.47 57.69, 63.92 -85.78, 14.86 277.56, 80.3 -62.91, -29.56 in-out in 8.304 Saltbr-out 4.707 HRD-in -68.14, -50.51 67.46, 2.9 out-in-out SNCoio in-out ActLoopNT-in 2.816 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -128.9, 162.73 APE9-dihe-na -74.02, 167.46 APE8-dihe-in -56.29, 150.3 APE8-rot-out 36.33 APE67-dihe-in -61.72, -30.52 -65.73, -24.93 APE12-dist-in 11.244 APE11-dist-out 5.34 APE10-dist-out 8.996 APE9-dist-in 3.808 None None None EM 2.5 999.0 999.0 J 391 307 0 0 0 0 [[12, 295]] 1.0 9qcv Homo sapiens CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 9SKQJ P50613 9 346 346.0 ANP:60401 ATPlike Inactive DFGin 7.089 16.079 BLAminus -134.4, -172.6 54.33, 63.76 -84.59, 21.04 273.82, 84.09 -68.06, -13.54 in-out in 8.685 Saltbr-out 3.604 HRD-in -66.63, -50.41 66.76, -1.97 out-in-out SNCoio in-out ActLoopNT-in 3.021 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -107.15, 155.19 APE9-dihe-na -64.85, 155.06 APE8-dihe-in -50.04, 149.57 APE8-rot-out 168.49 APE67-dihe-in -67.74, -34.69 -63.59, -17.75 APE12-dist-in 10.588 APE11-dist-out 5.67 APE10-dist-out 9.403 APE9-dist-in 3.987 None None None EM 3.4 999.0 999.0 J 391 306 0 0 0 0 [[12, 295]] 1.0 9skq Homo sapiens CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BA P50613 1 311 346.0 ANP:401 ATPlike Inactive DFGin 6.667 15.04 None -136.41, -179.13 75.36, -66.57 59.32, 16.33 291.11, 69.78 55.95, 32.69 out-out out 13.486 Saltbr-out 13.754 HRD-in -65.3, -54.78 73.94, 0.68 out-out-out SNCooo out-out ActLoopNT-out 12.55 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -74.63, 115.42 APE9-dihe-na -115.54, -2.31 APE8-dihe-out -56.05, -31.84 APE8-rot-out 157.42 APE67-dihe-in -63.34, -23.16 -66.49, -24.29 APE12-dist-out 18.002 APE11-dist-out 20.187 APE10-dist-out 16.086 APE9-dist-out 11.465 S164D,T170E None None XRAY 2.21 0.195 0.243 A 352 301 10 0 0 0 [[12, 295]] 1.0 8r9b Homo sapiens CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BB P50613 3 310 346.0 ANP:402 ATPlike Inactive DFGin 6.563 15.084 None -126.22, 177.01 84.52, -73.28 65.77, 22.93 292.14, 76.04 47.33, 39.02 out-out out 13.607 Saltbr-out 11.882 HRD-in -71.08, -53.54 74.78, -6.63 out-out-out SNCooo out-out ActLoopNT-out 12.936 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -81.04, 115.32 APE9-dihe-na -115.04, 1.93 APE8-dihe-out -60.49, -32.76 APE8-rot-out 168.86 APE67-dihe-in -59.67, -24.77 -68.61, -28.01 APE12-dist-out 17.779 APE11-dist-out 20.186 APE10-dist-out 16.157 APE9-dist-out 11.416 S164D,T170E None None XRAY 2.21 0.195 0.243 B 352 298 10 0 0 0 [[12, 295]] 1.0 8r9b Homo sapiens CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BC P50613 8 311 346.0 ANP:402 ATPlike Inactive DFGin 6.451 15.34 None -116.21, 176.78 77.39, -97.04 64.16, 26.01 311.61, 20.83 46.47, 58.36 out-out out 13.104 Saltbr-out 12.133 HRD-in -78.41, -55.45 77.67, -2.52 out-out-out SNCooo out-out ActLoopNT-out 12.922 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 132.76 APE9-dihe-na -87.2, -35.35 APE8-dihe-out -49.87, -35.32 APE8-rot-in 271.7 APE67-dihe-in -63.34, -21.13 -58.67, -34.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.928 APE9-dist-out 10.934 S164D,T170E None None XRAY 2.21 0.195 0.243 C 352 276 28 0 0 12 [[12, 295]] 1.0 8r9b Homo sapiens CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 8R9BD P50613 9 311 346.0 ANP:402 ATPlike Inactive DFGin 5.186 15.529 None -119.23, -173.72 58.44, -119.7 56.58, 114.74 106.06, 59.9 70.5, -151.21 out-out out 13.062 Saltbr-out 12.354 HRD-in -80.52, -56.05 80.67, -8.56 out-out-out SNCooo out-out ActLoopNT-out 13.055 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -29.49 APE9-dihe-na -113.47, -32.42 APE8-dihe-out -62.11, -27.52 APE8-rot-out 75.68 APE67-dihe-in -62.12, -24.79 -50.05, -35.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.16 APE9-dist-out 11.156 S164D,T170E None None XRAY 2.21 0.195 0.243 D 352 277 26 0 0 10 [[12, 295]] 1.0 8r9b Homo sapiens CMGC_CDK7_HUMAN CMGC 5.9e-78 269.9 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK9 CDK9_HUMAN 3MIAA P50750 8 340 372.0 ANP:352 ATPlike Active DFGin 6.803 15.077 BLAminus -137.71, 176.33 64.58, 74.97 -96.55, 26.44 284.7, 90.38 -67.18, -14.54 in-in in 9.313 Saltbr-in 2.689 HRD-in -70.81, -51.43 63.16, 28.9 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.04, 160.49 APE9-dihe-na 82.03, 127.94 APE8-dihe-in -49.75, 143.51 APE8-rot-in 280.63 APE67-dihe-in -52.26, -14.47 -51.96, -57.94 APE12-dist-in 13.258 APE11-dist-in 11.524 APE10-dist-in 6.949 APE9-dist-in 3.523 None TPO186 TPO186 XRAY 3.0 0.219 0.287 A 351 325 8 0 0 0 [[19, 315]] 1.0 3mia Homo sapiens CMGC_CDK9_HUMAN CMGC 5.1e-80 274.8 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CMGC CSNK2A1 CSK21_HUMAN 3JUHA P68400 2 335 391.0 ANP:339 ATPlike Active DFGin 7.401 16.242 BLAminus -115.69, -178.29 60.62, 71.57 -93.06, 11.37 295.1, 82.09 -62.22, -22.13 in-in in 9.721 Saltbr-in 2.746 HRD-in -70.06, -49.94 64.15, 21.46 in-in-in SNCiii in-in ActLoopNT-in 2.862 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.98, 153.86 APE9-dihe-na 70.33, -177.46 APE8-dihe-in -104.19, 142.14 APE8-rot-in 291.28 APE67-dihe-in -67.33, -12.83 -40.87, -55.27 APE12-dist-in 12.316 APE11-dist-in 9.578 APE10-dist-in 6.044 APE9-dist-in 3.086 V66A,M163L None None XRAY 1.66 0.158 0.218 A 335 334 0 0 0 0 [[39, 324]] 1.0 3juh Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.1e-70 244.1 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 3JUHB P68400 2 335 391.0 ANP:339 ATPlike Active DFGin 7.492 16.356 BLAminus -124.69, -176.29 51.46, 71.26 -80.35, 23.48 299.01, 83.37 -80.68, -22.43 in-in in 9.852 Saltbr-in 2.699 HRD-in -76.38, -50.5 78.84, -1.13 in-in-in SNCiii in-in ActLoopNT-in 2.807 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.59, 175.23 APE9-dihe-na 56.07, 138.8 APE8-dihe-in -58.03, 149.04 APE8-rot-in 282.66 APE67-dihe-in -69.98, -19.52 -43.94, -46.02 APE12-dist-in 12.714 APE11-dist-in 9.541 APE10-dist-in 5.884 APE9-dist-in 3.411 V66A,M163L None None XRAY 1.66 0.158 0.218 B 335 334 0 0 0 0 [[39, 324]] 1.0 3juh Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.1e-70 244.1 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 3NSZA P68400 2 328 391.0 ANP:1000 ATPlike Active DFGin 7.29 16.639 BLAminus -116.89, -174.28 57.53, 72.95 -91.24, 19.04 295.43, 81.74 -67.97, -19.44 in-in in 9.56 Saltbr-in 2.721 HRD-in -71.38, -46.87 68.1, 12.99 in-in-in SNCiii in-in ActLoopNT-in 2.869 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.59, 174.99 APE9-dihe-na 61.7, -173.37 APE8-dihe-in -118.84, 140.8 APE8-rot-in 296.4 APE67-dihe-in -69.07, -13.11 -30.5, -60.15 APE12-dist-in 12.605 APE11-dist-in 10.316 APE10-dist-in 6.145 APE9-dist-in 2.961 None None None XRAY 1.3 0.169 0.187 A 330 327 0 0 0 0 [[39, 324]] 1.0 3nsz Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.3e-69 240.7 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 1PJKA P68400 2 332 391.0 ANP:340 ATPlike Active DFGin 7.44 16.238 BLAminus -115.92, -179.78 53.21, 80.99 -96.44, 28.53 295.64, 78.1 -72.28, -30.66 in-in in 8.93 Saltbr-in 2.81 HRD-in -80.54, -40.11 57.34, 9.1 in-in-in SNCiii in-in ActLoopNT-in 3.019 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.58, 173.24 APE9-dihe-na 63.2, 174.94 APE8-dihe-in -93.15, 157.9 APE8-rot-in 277.8 APE67-dihe-in -66.77, -23.27 -54.74, -47.48 APE12-dist-in 13.026 APE11-dist-in 10.669 APE10-dist-in 6.368 APE9-dist-in 3.173 None None None XRAY 2.5 0.188 0.257 A 334 331 0 0 0 0 [[39, 324]] 1.0 1pjk Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.3e-69 240.6 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 2PVRA P68400 2 329 391.0 ANP:6004 ATPlike Active DFGin 7.492 16.497 BLAminus -121.67, -179.6 56.35, 70.32 -89.0, 17.49 296.64, 81.69 -72.81, -15.87 in-in in 9.284 Saltbr-in 2.7 HRD-in -75.03, -46.77 70.22, 6.37 in-in-in SNCiii in-in ActLoopNT-in 2.86 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.8, 175.01 APE9-dihe-na 60.61, 163.14 APE8-dihe-in -93.89, 147.69 APE8-rot-in 305.18 APE67-dihe-in -67.68, -15.16 -34.32, -58.13 APE12-dist-in 12.728 APE11-dist-in 10.346 APE10-dist-in 6.131 APE9-dist-in 3.189 None None None XRAY 1.605 0.187 0.241 A 334 328 0 0 0 0 [[39, 324]] 1.0 2pvr Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.3e-69 240.6 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 3WOWA P68400 2 335 391.0 ANP:403 ATPlike Inactive DFGin 7.362 16.211 BLAminus -119.7, -164.32 31.16, 87.67 -91.29, 15.78 292.48, 84.38 -76.59, -15.17 in-in in 9.013 Saltbr-in 2.897 HRD-in -75.03, -42.77 66.59, 8.6 in-in-out SNCiio in-out ActLoopNT-in 2.827 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -147.66, 173.4 APE9-dihe-na 59.33, 149.57 APE8-dihe-in -60.19, 149.81 APE8-rot-out 155.74 APE67-dihe-in -68.18, -10.89 -45.04, -52.54 APE12-dist-in 12.463 APE11-dist-in 9.893 APE10-dist-in 6.004 APE9-dist-in 3.238 None None None XRAY 2.5 0.187 0.24 A 340 334 0 0 0 0 [[39, 324]] 1.0 3wow Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.4e-69 240.5 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 1JWHA P68400 2 337 391.0 ANP:340 ATPlike Inactive DFGin 7.252 16.235 BLAminus -136.81, -165.56 40.66, 74.27 -89.27, 13.16 294.34, 91.77 -66.65, -32.67 in-in in 9.564 Saltbr-in 2.506 HRD-in -80.54, -35.51 50.69, 18.56 in-in-out SNCiio in-out ActLoopNT-in 2.932 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -124.17, 169.91 APE9-dihe-na 68.04, 157.3 APE8-dihe-in -72.41, 153.53 APE8-rot-out 204.94 APE67-dihe-in -51.97, -16.72 -49.32, -64.87 APE12-dist-in 12.731 APE11-dist-in 10.856 APE10-dist-in 6.286 APE9-dist-in 3.369 None None None XRAY 3.1 0.267 0.338 A 337 336 0 0 0 0 [[39, 324]] 1.0 1jwh Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.4e-69 240.6 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 3U87A P68400 2 331 391.0 ANP:60401 ATPlike Inactive DFGin 7.545 16.231 BLAminus -123.37, -169.57 51.0, 85.39 -106.65, 25.22 299.48, 83.64 -72.72, -19.34 in-in in 9.267 Saltbr-in 2.765 HRD-in -71.91, -49.46 70.99, 8.66 in-in-out SNCiio in-out ActLoopNT-in 2.851 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.96, 169.28 APE9-dihe-na 66.95, 166.44 APE8-dihe-in -75.94, 153.25 APE8-rot-out 174.74 APE67-dihe-in -70.96, -11.07 -53.15, -46.69 APE12-dist-in 12.843 APE11-dist-in 11.035 APE10-dist-in 6.142 APE9-dist-in 3.539 None None None XRAY 2.9 0.187 0.218 A 349 324 0 0 0 0 [[39, 324]] 1.0 3u87 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.5e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 3U87B P68400 2 331 391.0 ANP:60401 ATPlike Active DFGin 7.471 16.335 BLAminus -123.33, -169.35 50.94, 85.5 -106.65, 24.88 299.58, 83.47 -72.97, -19.72 in-in in 9.505 Saltbr-in 2.848 HRD-in -72.0, -49.6 70.96, 8.41 in-in-in SNCiii in-in ActLoopNT-in 2.78 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.34, 168.89 APE9-dihe-na 66.61, 166.24 APE8-dihe-in -76.34, 153.62 APE8-rot-in 296.27 APE67-dihe-in -70.99, -10.83 -52.99, -46.79 APE12-dist-in 12.822 APE11-dist-in 10.801 APE10-dist-in 6.15 APE9-dist-in 3.577 None None None XRAY 2.9 0.187 0.218 B 349 324 0 0 0 0 [[39, 324]] 1.0 3u87 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.5e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A2 CSK22_HUMAN 8QCGA P19784 7 330 350.0 ANP:401 ATPlike Inactive DFGin 7.292 16.406 BLAminus -116.12, -179.5 60.93, 75.12 -92.44, 17.38 295.14, 82.0 -69.37, -19.53 in-out in 9.997 Saltbr-out 4.596 HRD-in -74.12, -49.68 72.07, 8.96 out-in-in SNCoii in-in ActLoopNT-in 2.89 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.46, 172.69 APE9-dihe-na 61.42, 170.02 APE8-dihe-in -97.67, 147.66 APE8-rot-in 300.74 APE67-dihe-in -69.16, -14.55 -36.76, -56.59 APE12-dist-in 12.627 APE11-dist-in 10.181 APE10-dist-in 6.131 APE9-dist-in 3.12 C336S None None XRAY 1.04 0.151 0.17 A 364 324 0 0 0 0 [[40, 325]] 1.0 8qcg Homo sapiens CMGC_CSNK2A2_HUMAN CMGC 1e-69 241.0 1 301 301 175 176 177 179 181 69 82 86 154 156 155 157 215 202 197 196 195 194 193 192 191 115 Casein kinase II subunit alpha'
CMGC CSNK2A2 CSK22_HUMAN 8QCGB P19784 7 333 350.0 ANP:401 ATPlike Active DFGin 7.314 16.209 BLAminus -113.91, -178.96 61.11, 75.42 -92.86, 17.98 298.38, 79.8 -69.62, -20.0 in-in in 9.436 Saltbr-in 2.83 HRD-in -72.51, -49.6 69.57, 9.93 in-in-in SNCiii in-in ActLoopNT-in 2.828 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.91, 170.94 APE9-dihe-na 61.2, 166.37 APE8-dihe-in -93.43, 149.98 APE8-rot-in 300.62 APE67-dihe-in -69.2, -15.18 -40.28, -54.89 APE12-dist-in 12.657 APE11-dist-in 10.295 APE10-dist-in 6.172 APE9-dist-in 3.11 C336S None None XRAY 1.04 0.151 0.17 B 364 327 0 0 0 0 [[40, 325]] 1.0 8qcg Homo sapiens CMGC_CSNK2A2_HUMAN CMGC 1e-69 241.0 1 301 301 175 176 177 179 181 69 82 86 154 156 155 157 215 202 197 196 195 194 193 192 191 115 Casein kinase II subunit alpha'
CMGC DYRK1A DYR1A_HUMAN 7A4OA Q13627 136 481 763.0 ANP:501 ATPlike Active DFGin 7.404 15.034 BLAminus -121.6, 173.77 67.88, 73.96 -92.34, 22.26 284.87, 82.1 -70.26, -21.97 in-in in 8.684 Saltbr-in 2.793 HRD-in -65.03, -49.19 79.83, -0.94 in-in-in SNCiii in-in ActLoopNT-in 2.8 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.61, 174.39 APE9-dihe-na 70.74, 151.67 APE8-dihe-in -72.34, 134.57 APE8-rot-in 295.77 APE67-dihe-in -65.19, -24.46 -43.45, -47.13 APE12-dist-in 10.098 APE11-dist-in 12.237 APE10-dist-in 7.723 APE9-dist-in 3.156 None PTR321 PTR321 XRAY 1.9 0.18 0.203 A 382 341 5 0 0 0 [[159, 479]] 1.0 7a4o Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK1A DYR1A_HUMAN 7A4OB Q13627 134 481 763.0 ANP:501 ATPlike Inactive DFGin 7.223 15.047 BLAminus -127.4, 170.29 72.8, 80.08 -93.18, 24.5 286.73, 76.67 -71.46, -26.03 in-in in 8.365 Saltbr-in 2.797 HRD-in -57.9, -49.71 71.19, 2.83 in-in-out SNCiio in-out ActLoopNT-in 2.84 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -84.65, 164.16 APE9-dihe-na 75.07, 150.77 APE8-dihe-in -68.35, 138.34 APE8-rot-in 298.16 APE67-dihe-in -63.89, -24.74 -46.52, -48.39 APE12-dist-out 14.097 APE11-dist-in 11.896 APE10-dist-in 7.537 APE9-dist-in 3.028 None PTR321 PTR321 XRAY 1.9 0.18 0.203 B 382 341 7 0 0 0 [[159, 479]] 1.0 7a4o Homo sapiens CMGC_DYRK1A_HUMAN CMGC 1e-90 310.0 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC GSK3B GSK3B_HUMAN 1J1BA P49841 35 388 420.0 ANP:60430 ATPlike Active DFGin 6.767 13.788 BLAminus -136.8, -178.88 61.6, 83.12 -97.64, 25.1 286.09, 80.4 -68.7, -13.11 in-in in 8.566 Saltbr-in 2.59 HRD-in -71.16, -45.98 70.36, 3.88 in-in-in SNCiii in-in ActLoopNT-in 3.009 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -88.52, 175.26 APE9-dihe-na 75.44, 133.64 APE8-dihe-in -75.76, 147.49 APE8-rot-in 306.57 APE67-dihe-inflip 98.15, -33.72 -56.43, 141.52 APE12-dist-in 13.056 APE11-dist-in 10.974 APE10-dist-in 5.893 APE9-dist-in 3.112 None None None XRAY 1.8 0.216 0.242 A 420 354 0 0 0 0 [[56, 340]] 1.0 1j1b Homo sapiens CMGC_GSK3B_HUMAN CMGC 3.2e-70 242.8 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 1J1BB P49841 23 386 420.0 ANP:60930 ATPlike Active DFGin 6.609 13.669 BLAminus -136.4, -177.03 61.49, 81.88 -98.08, 27.2 288.49, 82.07 -71.33, -13.14 in-in in 8.457 Saltbr-in 2.713 HRD-in -67.51, -45.87 68.87, 6.43 in-in-in SNCiii in-in ActLoopNT-in 2.962 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -90.88, 174.17 APE9-dihe-na 76.18, 138.08 APE8-dihe-in -76.12, 141.41 APE8-rot-in 301.11 APE67-dihe-inflip 98.0, -37.59 -54.78, 144.25 APE12-dist-in 12.978 APE11-dist-in 11.066 APE10-dist-in 6.011 APE9-dist-in 3.174 None None None XRAY 1.8 0.216 0.242 B 420 364 0 0 0 0 [[56, 340]] 1.0 1j1b Homo sapiens CMGC_GSK3B_HUMAN CMGC 3.2e-70 242.8 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 8XN6A P49841 35 384 420.0 ANP:501 ATPlike Active DFGin 6.682 13.862 BLAminus -137.72, 173.39 67.73, 84.48 -99.84, 22.57 287.77, 80.54 -65.33, -24.58 in-in in 8.463 Saltbr-in 2.63 HRD-in -71.05, -47.88 67.82, 15.5 in-in-in SNCiii in-in ActLoopNT-in 3.054 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.0, 164.43 APE9-dihe-na 85.44, 135.36 APE8-dihe-in -74.2, 151.55 APE8-rot-in 291.81 APE67-dihe-in -69.28, -17.83 -36.59, -67.98 APE12-dist-in 12.907 APE11-dist-in 10.787 APE10-dist-in 5.68 APE9-dist-in 3.182 None None None XRAY 2.4 0.194 0.242 A 421 350 0 0 0 0 [[56, 340]] 1.0 8xn6 Homo sapiens CMGC_GSK3B_HUMAN CMGC 3.3e-70 242.8 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 8XN6B P49841 26 386 420.0 ANP:501 ATPlike Inactive DFGin 6.538 13.65 BLAminus -128.79, 173.26 73.68, 79.74 -95.9, 22.51 291.63, 80.46 -68.54, -21.83 in-in in 8.329 Saltbr-in 2.823 HRD-in -66.59, -53.03 79.09, 5.6 in-in-out SNCiio in-out ActLoopNT-in 2.951 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -88.32, 165.9 APE9-dihe-na 83.63, 132.42 APE8-dihe-in -59.67, 147.17 APE8-rot-out 189.94 APE67-dihe-in -64.51, -21.68 -60.38, -49.59 APE12-dist-in 13.024 APE11-dist-in 10.97 APE10-dist-in 5.846 APE9-dist-in 3.081 None None None XRAY 2.4 0.194 0.242 B 421 359 2 0 0 0 [[56, 340]] 1.0 8xn6 Homo sapiens CMGC_GSK3B_HUMAN CMGC 3.3e-70 242.8 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 1PYXA P49841 35 386 420.0 ANP:1001 ATPlike Active DFGin 6.584 13.622 BLAminus -138.81, -178.07 65.18, 79.92 -98.83, 26.07 289.95, 78.27 -73.24, -7.6 in-in in 8.373 Saltbr-in 2.765 HRD-in -67.79, -47.84 71.28, 6.53 in-in-in SNCiii in-in ActLoopNT-in 2.948 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -86.12, 170.17 APE9-dihe-na 80.64, 129.74 APE8-dihe-in -63.79, 140.05 APE8-rot-in 299.48 APE67-dihe-in -56.43, -21.61 -20.65, -80.28 APE12-dist-in 12.903 APE11-dist-in 10.937 APE10-dist-in 5.784 APE9-dist-in 3.15 None None None XRAY 2.4 0.206 0.233 A 422 343 9 0 0 0 [[56, 340]] 1.0 1pyx Homo sapiens CMGC_GSK3B_HUMAN CMGC 3.3e-70 242.8 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 1PYXB P49841 35 383 420.0 ANP:2001 ATPlike Active DFGin 6.593 13.718 BLAminus -140.94, -178.47 65.26, 79.98 -98.11, 22.32 290.75, 76.51 -68.32, -7.73 in-in in 8.488 Saltbr-in 2.666 HRD-in -69.98, -47.18 70.83, 5.6 in-in-in SNCiii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -89.3, 169.41 APE9-dihe-na 81.27, 131.24 APE8-dihe-in -66.67, 140.79 APE8-rot-in 300.74 APE67-dihe-in -56.9, -22.2 -20.58, -79.9 APE12-dist-in 12.838 APE11-dist-in 10.861 APE10-dist-in 5.718 APE9-dist-in 3.132 None None None XRAY 2.4 0.206 0.233 B 422 338 11 0 0 0 [[56, 340]] 1.0 1pyx Homo sapiens CMGC_GSK3B_HUMAN CMGC 3.3e-70 242.8 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC MAPK1 MK01_HUMAN 4H3QA P28482 9 360 360.0 ANP:401 ATPlike Inactive DFGin 6.603 15.682 BLAminus -131.43, 178.9 70.32, 68.42 -96.0, 22.91 290.2, 68.59 -63.35, -20.75 in-in in 9.233 Saltbr-in 2.821 HRD-in -71.26, -48.66 68.7, 4.98 in-in-out SNCiio in-out ActLoopNT-in 2.942 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_iioo APE10-dihe-na -133.14, 155.68 APE9-dihe-na -60.56, -35.88 APE8-dihe-out -124.57, -73.58 APE8-rot-out 150.68 APE67-dihe-out -67.06, -6.51 92.51, -9.23 APE12-dist-in 9.135 APE11-dist-in 11.662 APE10-dist-out 8.752 APE9-dist-out 10.9 R77A,C161S,I255G,E314A None None XRAY 2.2 0.184 0.232 A 362 352 0 0 0 0 [[25, 313]] 1.0 4h3q Homo sapiens CMGC_MAPK1_HUMAN CMGC 3.4e-85 291.8 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 6OPGA P28482 10 358 360.0 ANP:60401 ATPlike Active DFGin 6.535 14.668 BLAminus -130.49, -173.97 55.35, 72.85 -87.66, 25.26 285.94, 65.79 -65.31, -19.22 in-in in 9.066 Saltbr-in 2.695 HRD-in -72.87, -54.34 77.9, 3.87 in-in-in SNCiii in-in ActLoopNT-in 2.758 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -102.35, 163.88 APE9-dihe-na 79.13, 168.47 APE8-dihe-in -88.92, 138.85 APE8-rot-in 292.11 APE67-dihe-in -68.23, -14.82 -51.35, -45.86 APE12-dist-in 12.57 APE11-dist-in 11.134 APE10-dist-in 6.653 APE9-dist-in 2.942 None TPO185,PTR187 TPO185,PTR187 XRAY 2.9 0.16 0.239 A 354 349 0 0 0 0 [[25, 313]] 1.0 6opg Homo sapiens CMGC_MAPK1_HUMAN CMGC 8.6e-86 293.8 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 2Y9QA P28482 9 358 360.0 ANP:1359 ATPlike Inactive DFGin 6.776 15.446 BLAminus -131.56, -173.58 71.27, 62.6 -94.15, 18.41 284.56, 67.7 -60.61, -22.82 in-in in 9.107 Saltbr-in 2.791 HRD-in -69.38, -48.16 75.91, -5.63 in-in-out SNCiio in-out ActLoopNT-in 2.788 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -136.29, 162.19 APE9-dihe-na -69.67, -30.11 APE8-dihe-in -153.45, 140.36 APE8-rot-out 183.83 APE67-dihe-in -69.16, -12.41 -110.3, 4.7 APE12-dist-in 9.663 APE11-dist-in 12.83 APE10-dist-out 9.194 APE9-dist-out 11.509 None None None XRAY 1.55 0.156 0.177 A 362 350 0 0 0 0 [[25, 313]] 1.0 2y9q Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.3e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4FMQA P28482 9 358 360.0 ANP:401 ATPlike Inactive DFGin 6.797 15.309 BLAminus -133.64, -170.94 67.61, 66.1 -98.24, 21.64 282.65, 68.61 -61.3, -22.42 in-in in 9.131 Saltbr-in 2.936 HRD-in -73.07, -47.52 74.25, -10.43 in-in-out SNCiio in-out ActLoopNT-in 2.83 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -138.4, 159.9 APE9-dihe-na -70.94, -24.68 APE8-dihe-in -158.11, 141.22 APE8-rot-out 179.47 APE67-dihe-in -66.85, -11.48 -113.88, 6.26 APE12-dist-in 9.474 APE11-dist-in 12.7 APE10-dist-out 9.225 APE9-dist-out 11.64 None None None XRAY 2.098 0.182 0.224 A 362 350 0 0 0 0 [[25, 313]] 1.0 4fmq Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.3e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4NIFB P28482 9 360 360.0 ANP:401 ATPlike Inactive DFGin 6.764 15.409 BLAminus -131.87, -169.42 69.51, 63.01 -98.39, 22.71 281.57, 68.87 -63.28, -26.61 in-in in 9.008 Saltbr-in 2.783 HRD-in -68.77, -49.09 76.18, -3.84 in-in-out SNCiio in-out ActLoopNT-in 2.728 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -127.8, 161.08 APE9-dihe-na -75.51, -26.3 APE8-dihe-in -152.23, 138.84 APE8-rot-out 180.18 APE67-dihe-in -71.26, -8.82 -111.88, 5.33 APE12-dist-in 8.2 APE11-dist-in 11.961 APE10-dist-out 8.903 APE9-dist-out 11.513 None None None XRAY 2.15 0.161 0.208 B 362 349 3 0 0 3 [[25, 313]] 1.0 4nif Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.3e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4NIFE P28482 10 360 360.0 ANP:401 ATPlike Inactive DFGin 6.799 15.601 BLAminus -132.52, -168.43 65.68, 64.41 -97.79, 21.09 277.61, 67.0 -63.55, -23.2 in-in in 9.17 Saltbr-in 2.713 HRD-in -70.38, -48.01 73.58, -2.52 in-in-out SNCiio in-out ActLoopNT-in 2.729 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -128.04, 157.14 APE9-dihe-na -71.47, -27.38 APE8-dihe-in -153.58, 137.78 APE8-rot-out 179.37 APE67-dihe-in -68.22, -5.95 -110.7, 4.02 APE12-dist-in 8.144 APE11-dist-in 11.929 APE10-dist-out 8.941 APE9-dist-out 11.528 None None None XRAY 2.15 0.161 0.208 E 362 348 3 0 0 3 [[25, 313]] 1.0 4nif Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.3e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8PSRA P28482 1 358 360.0 ANP:401 ATPlike Inactive DFGin 6.763 15.116 BLAminus -130.96, -167.28 68.25, 62.57 -95.64, 20.11 282.69, 71.74 -68.98, -15.25 in-in in 8.941 Saltbr-in 2.823 HRD-in -68.74, -46.55 75.16, -5.99 in-in-out SNCiio in-out ActLoopNT-in 2.769 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -133.02, 153.53 APE9-dihe-na -66.89, -30.36 APE8-dihe-in -146.2, 134.03 APE8-rot-out 178.25 APE67-dihe-in -71.02, -10.13 -100.56, 5.83 APE12-dist-in 8.168 APE11-dist-in 11.547 APE10-dist-out 8.889 APE9-dist-out 11.361 None None None XRAY 1.85 0.183 0.209 A 364 354 4 0 0 4 [[25, 313]] 1.0 8psr Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 3TEIA P28482 10 358 360.0 ANP:401 ATPlike Inactive DFGin 6.743 15.947 BLAminus -130.8, -176.53 59.31, 74.36 -93.64, 10.5 288.08, 72.41 -50.44, -31.09 in-in in 9.271 Saltbr-in 3.199 HRD-in -69.93, -52.25 74.6, -17.82 in-in-out SNCiio in-out ActLoopNT-in 2.753 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na 66.02, 77.59 APE9-dihe-na -53.11, -45.5 APE8-dihe-in -109.04, 134.77 APE8-rot-out 40.2 APE67-dihe-in -60.63, -33.66 -94.81, 4.48 APE12-dist-in 8.784 APE11-dist-in 10.993 APE10-dist-out 8.507 APE9-dist-out 11.182 R77A,E314A None None XRAY 2.404 0.199 0.235 A 362 339 10 0 0 7 [[25, 313]] 1.0 3tei Homo sapiens CMGC_MAPK1_HUMAN CMGC 1.6e-85 292.9 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4H3PA P28482 11 359 360.0 ANP:401 ATPlike Inactive DFGin 6.749 16.129 BLAminus -129.02, -179.26 65.06, 71.95 -98.46, 28.28 294.01, 75.31 -57.14, -23.59 in-in in 9.601 Saltbr-in 3.052 HRD-in -79.45, -54.12 78.74, 4.99 in-in-out SNCiio in-out ActLoopNT-in 2.727 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -109.42, 169.7 APE9-dihe-na -56.98, -72.96 APE8-dihe-in -103.33, 144.18 APE8-rot-out 6.69 APE67-dihe-in -56.41, -28.74 -91.67, -5.29 APE12-dist-in 8.895 APE11-dist-in 9.185 APE10-dist-out 8.383 APE9-dist-out 9.732 R77A,E314A None None XRAY 2.3 0.18 0.224 A 362 342 7 0 0 7 [[25, 313]] 1.0 4h3p Homo sapiens CMGC_MAPK1_HUMAN CMGC 1.6e-85 292.9 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4H3PD P28482 11 359 360.0 ANP:401 ATPlike Inactive DFGin 6.742 16.27 BLAminus -128.42, -178.25 63.92, 70.53 -94.38, 28.0 287.67, 73.89 -60.9, -21.54 in-in in 9.383 Saltbr-in 3.454 HRD-in -75.51, -54.76 82.18, -2.55 in-in-out SNCiio in-out ActLoopNT-in 2.657 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 42.36 APE8-rot-out 66.34 APE67-dihe-in -61.9, -28.03 -63.57, -9.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 R77A,E314A None None XRAY 2.3 0.18 0.224 D 362 338 11 0 0 11 [[25, 313]] 1.0 4h3p Homo sapiens CMGC_MAPK1_HUMAN CMGC 1.6e-85 292.9 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8PT0A P28482 11 358 360.0 ANP:401,EAI:403 ATPlike,Allosteric Inactive DFGin 6.703 15.518 BLAminus -130.99, -173.26 73.92, 62.07 -95.1, 17.63 279.55, 70.77 -68.45, -13.49 in-in in 9.141 Saltbr-in 2.87 HRD-in -71.96, -48.9 77.41, -4.12 in-in-out SNCiio in-out ActLoopNT-in 2.692 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -110.07, -36.78 APE9-dihe-na -83.86, 177.79 APE8-dihe-in -68.52, 145.31 APE8-rot-out 191.04 APE67-dihe-in -66.51, -15.78 -105.25, 7.42 APE12-dist-out 6.875 APE11-dist-in 12.443 APE10-dist-out 12.554 APE9-dist-out 9.994 None None None XRAY 1.65 0.178 0.207 A 364 348 0 0 0 0 [[25, 313]] 1.0 8pt0 Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8PT1A P28482 11 359 360.0 ANP:401,E2A:402 ATPlike,Allosteric Inactive DFGin 6.753 15.486 BLAminus -130.01, -175.04 73.39, 64.08 -95.46, 18.76 282.28, 68.91 -63.67, -19.55 in-in in 9.189 Saltbr-in 2.849 HRD-in -70.21, -47.68 76.07, -5.14 in-in-out SNCiio in-out ActLoopNT-in 2.672 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -121.06, -17.86 APE9-dihe-na -106.9, -177.78 APE8-dihe-in -78.1, 145.34 APE8-rot-out 186.54 APE67-dihe-in -67.62, -15.27 -108.68, 6.96 APE12-dist-in 7.171 APE11-dist-in 12.615 APE10-dist-out 12.631 APE9-dist-out 10.275 None None None XRAY 1.8 0.18 0.206 A 364 349 0 0 0 0 [[25, 313]] 1.0 8pt1 Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8PT5A P28482 10 358 360.0 ANP:401,D5R:402 ATPlike,Allosteric Inactive DFGin 6.79 15.304 BLAminus -138.03, -165.34 60.19, 62.86 -94.09, 21.06 289.01, 63.44 -59.86, -23.15 in-in in 9.091 Saltbr-in 2.882 HRD-in -75.18, -47.36 71.89, 2.28 in-in-out SNCiio in-out ActLoopNT-in 2.686 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -138.15, 158.79 APE9-dihe-na -71.62, -19.38 APE8-dihe-in -154.23, 140.23 APE8-rot-out 183.5 APE67-dihe-in -63.22, -13.66 -125.12, 20.04 APE12-dist-in 7.631 APE11-dist-in 11.469 APE10-dist-out 8.739 APE9-dist-out 11.287 None None None XRAY 1.95 0.206 0.235 A 364 336 10 0 0 10 [[25, 313]] 1.0 8pt5 Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8R5FA P28482 11 359 360.0 ANP:401,Y3H:403 ATPlike,Allosteric Inactive DFGin 6.715 15.459 BLAminus -133.12, -173.02 67.59, 67.52 -98.89, 23.72 283.56, 67.1 -69.6, -17.36 in-in in 9.141 Saltbr-in 2.907 HRD-in -75.1, -48.03 76.68, -4.69 in-in-out SNCiio in-out ActLoopNT-in 2.693 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -92.27 APE8-dihe-in -89.34, 137.7 APE8-rot-out 190.9 APE67-dihe-in -68.19, -17.69 -92.76, -0.83 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.617 None None None XRAY 1.65 0.194 0.218 A 364 337 12 0 0 12 [[25, 313]] 1.0 8r5f Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8PT3A P28482 10 359 360.0 D7O:401,ANP:405 Allosteric,ATPlike Inactive DFGin 6.746 16.295 BLAminus -133.05, 179.18 60.24, 82.09 -94.36, 25.54 283.73, 70.47 -58.59, -24.6 in-out in 9.278 Saltbr-out 4.094 HRD-in -70.52, -51.82 77.79, -2.53 out-in-out SNCoio in-out ActLoopNT-in 2.751 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oiio APE10-dihe-na -134.69, 123.91 APE9-dihe-na -78.34, -33.65 APE8-dihe-in -152.41, 145.11 APE8-rot-out 185.39 APE67-dihe-in -63.56, -20.16 -105.73, 9.6 APE12-dist-out 6.368 APE11-dist-in 8.592 APE10-dist-in 7.973 APE9-dist-out 9.858 None None None XRAY 1.8 0.189 0.222 A 364 344 6 0 0 6 [[25, 313]] 1.0 8pt3 Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.5e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK10 MK10_HUMAN 8WGFA P53779 44 400 464.0 ANP:60401 ATPlike Inactive DFGin 3.669 14.04 ABAminus -79.02, -31.55 -136.84, 175.04 -119.07, 8.28 296.56, 96.93 82.35, -157.09 in-out in 9.384 Saltbr-out 5.018 HRD-in -58.91, -63.96 74.85, 1.04 out-out-out SNCooo out-out ActLoopNT-out 7.325 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -90.96, 137.03 APE9-dihe-na -73.55, 128.96 APE8-dihe-in -72.45, 116.03 APE8-rot-in 306.62 APE67-dihe-in -62.34, -20.8 -105.53, -9.26 APE12-dist-out 20.953 APE11-dist-out 15.692 APE10-dist-out 16.374 APE9-dist-out 11.022 None None None XRAY 1.85 0.212 0.266 A 364 345 4 0 0 4 [[64, 359]] 1.0 8wgf Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 1JNKA P53779 45 400 464.0 ANP:1001 ATPlike Inactive DFGin 3.929 14.397 ABAminus -78.22, -57.34 -98.44, 177.55 -110.1, 6.65 294.57, 85.06 91.46, -137.75 in-out in 9.683 Saltbr-out 4.075 HRD-in -45.57, -68.64 69.61, 1.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -66.55, 160.68 APE9-dihe-na -118.58, 134.57 APE8-dihe-in -89.41, 118.53 APE8-rot-in 305.71 APE67-dihe-in -40.1, -24.2 -103.88, -20.46 APE12-dist-out 21.317 APE11-dist-out 17.873 APE10-dist-out 16.746 APE9-dist-out 11.497 None None None XRAY 2.3 0.222 0.274 A 423 346 5 0 0 5 [[64, 359]] 1.0 1jnk Homo sapiens CMGC_MAPK10_HUMAN CMGC 2.3e-85 292.5 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 4Z9LA P53779 45 400 464.0 ANP:501,880:502 Allosteric,Type1 Inactive DFGin 4.174 14.445 ABAminus -84.27, -25.72 -124.69, 176.34 -117.02, 11.08 300.14, 92.59 64.94, -148.04 out-out out 10.091 Saltbr-out 4.206 HRD-in -57.93, -67.24 75.49, -7.3 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 141.12 APE8-dihe-in -74.24, 114.86 APE8-rot-in 306.24 APE67-dihe-in -45.55, -30.35 -108.57, -9.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.617 None None None XRAY 2.1 0.201 0.226 A 364 333 12 0 0 10 [[64, 359]] 1.0 4z9l Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK12 MK12_HUMAN 1CM8A P53778 8 353 367.0 ANP:60400 ATPlike Active DFGin 6.965 14.774 BLAminus -109.08, -177.81 49.88, 82.62 -94.66, 21.96 279.65, 74.31 -61.38, -21.21 in-in in 9.0 Saltbr-in 2.777 HRD-in -80.35, -48.18 64.34, 20.91 in-in-in SNCiii in-in ActLoopNT-in 2.793 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.88, 159.85 APE9-dihe-na 73.62, 141.22 APE8-dihe-in -70.32, 134.6 APE8-rot-in 295.09 APE67-dihe-in -62.17, -12.08 -34.13, -61.33 APE12-dist-in 11.604 APE11-dist-in 10.956 APE10-dist-in 6.991 APE9-dist-in 3.072 None TPO183,PTR185 TPO183,PTR185 XRAY 2.4 0.232 0.283 A 367 329 6 0 0 0 [[27, 311]] 1.0 1cm8 Homo sapiens CMGC_MAPK12_HUMAN CMGC 5.6e-85 291.2 1 301 301 170 171 172 174 176 56 74 78 150 152 151 153 208 195 190 189 188 187 186 185 184 110 Mitogen-activated protein kinase 12
CMGC MAPK12 MK12_HUMAN 1CM8B P53778 8 353 367.0 ANP:61400 ATPlike Active DFGin 6.965 14.794 BLAminus -106.93, -177.79 50.51, 81.99 -94.3, 22.09 279.91, 74.94 -61.07, -21.75 in-in in 9.031 Saltbr-in 2.759 HRD-in -80.7, -47.04 63.03, 19.82 in-in-in SNCiii in-in ActLoopNT-in 2.817 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.88, 160.62 APE9-dihe-na 73.12, 141.25 APE8-dihe-in -70.38, 133.34 APE8-rot-in 295.67 APE67-dihe-in -62.05, -11.85 -33.55, -61.0 APE12-dist-in 11.613 APE11-dist-in 10.95 APE10-dist-in 6.996 APE9-dist-in 3.048 None TPO183,PTR185 TPO183,PTR185 XRAY 2.4 0.232 0.283 B 367 329 6 0 0 0 [[27, 311]] 1.0 1cm8 Homo sapiens CMGC_MAPK12_HUMAN CMGC 5.6e-85 291.2 1 301 301 170 171 172 174 176 56 74 78 150 152 151 153 208 195 190 189 188 187 186 185 184 110 Mitogen-activated protein kinase 12
CMGC MAPK7 MK07_HUMAN 4IC7A Q13164 46 400 816.0 ANP:60501 ATPlike Inactive DFGin 6.963 15.707 BLAminus -112.54, -170.45 61.6, 71.09 -94.22, 5.13 285.3, 80.28 -60.77, -23.83 in-in in 9.45 Saltbr-in 2.911 HRD-in -64.26, -48.71 75.06, -19.07 in-in-out SNCiio in-out ActLoopNT-in 3.184 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na 163.57, 152.54 APE9-dihe-na -166.15, 155.73 APE8-dihe-in -57.6, 140.19 APE8-rot-out 163.75 APE67-dihe-in -65.59, -38.02 -73.56, -13.59 APE12-dist-in 8.83 APE11-dist-out 6.338 APE10-dist-out 8.509 APE9-dist-in 5.809 None None None XRAY 2.6 0.213 0.258 A 442 355 0 0 0 0 [[55, 347]] 1.0 4ic7 Homo sapiens CMGC_MAPK7_HUMAN CMGC 1.4e-81 280.1 1 301 301 199 200 201 203 205 84 102 106 179 181 180 182 244 231 226 225 224 223 222 221 220 138 Mitogen-activated protein kinase 7
CMGC MAPK7 MK07_HUMAN 4IC7D Q13164 47 399 816.0 ANP:60501 ATPlike Inactive DFGin 6.921 15.491 BLAminus -111.52, -167.35 56.73, 75.91 -99.28, 4.79 286.66, 84.61 -57.3, -28.24 in-in in 9.382 Saltbr-in 3.274 HRD-in -69.27, -53.54 75.02, -19.96 in-in-out SNCiio in-out ActLoopNT-in 3.043 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -103.14, 107.5 APE9-dihe-na -135.73, 156.83 APE8-dihe-in -63.07, 155.1 APE8-rot-out 142.76 APE67-dihe-in -57.29, -43.39 -78.84, -17.33 APE12-dist-in 8.83 APE11-dist-out 6.981 APE10-dist-out 8.351 APE9-dist-in 5.57 None None None XRAY 2.6 0.213 0.258 D 442 353 0 0 0 0 [[55, 347]] 1.0 4ic7 Homo sapiens CMGC_MAPK7_HUMAN CMGC 1.4e-81 280.1 1 301 301 199 200 201 203 205 84 102 106 179 181 180 182 244 231 226 225 224 223 222 221 220 138 Mitogen-activated protein kinase 7
CMGC MAPK8 MK08_HUMAN 6ZR5A P45983 3 362 427.0 ANP:60402 ATPlike Inactive DFGin 3.817 14.226 ABAminus -84.03, -42.55 -114.88, 174.79 -114.82, 8.54 299.13, 101.86 79.5, -168.62 out-out out 10.002 Saltbr-out 5.031 HRD-in -56.29, -55.44 70.4, -2.27 out-out-out SNCooo out-out ActLoopNT-out 6.872 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 107.14 APE8-rot-out 87.08 APE67-dihe-in -67.28, -21.26 -101.91, 26.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.699 0.186 0.256 A 366 348 12 0 0 12 [[26, 321]] 1.0 6zr5 Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 6ZR5B P45983 4 362 427.0 ANP:60400 ATPlike Inactive DFGin 3.867 14.072 ABAminus -85.51, -41.13 -110.19, 172.79 -115.96, 8.05 294.61, 92.39 79.48, -170.78 out-out out 10.021 Saltbr-out 4.224 HRD-in -59.93, -50.9 67.15, -3.15 out-out-out SNCooo out-out ActLoopNT-out 6.849 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -100.6, 89.98 APE9-dihe-na -140.16, 151.66 APE8-dihe-in -87.57, 109.71 APE8-rot-in 298.46 APE67-dihe-in -73.45, -13.54 -100.12, 16.22 APE12-dist-out 17.551 APE11-dist-in 12.898 APE10-dist-out 16.341 APE9-dist-out 11.496 None None None XRAY 2.699 0.186 0.256 B 366 359 0 0 0 0 [[26, 321]] 1.0 6zr5 Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 2XRWA P45983 2 364 427.0 ANP:61367 ATPlike Inactive DFGin 3.816 13.941 ABAminus -85.3, -24.5 -153.59, -177.02 -115.68, 7.02 304.14, 97.05 88.01, -156.78 in-out in 9.886 Saltbr-out 4.635 HRD-in -83.3, -58.4 77.36, -14.29 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.45, -23.57 999.0, -3.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.33 0.166 0.187 A 371 347 16 0 0 16 [[26, 321]] 1.0 2xrw Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.5e-85 290.5 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 2XS0A P45983 6 365 427.0 ANP:1367 ATPlike Inactive DFGin 3.754 14.081 ABAminus -75.25, -22.88 -148.14, -178.22 -116.01, 26.92 303.04, 86.85 61.81, -161.42 in-out in 9.735 Saltbr-out 5.55 HRD-in -69.33, -60.51 78.49, -20.02 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 173.45 APE8-rot-out 188.87 APE67-dihe-out -73.26, -26.46 -135.55, 95.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T183V,Y185F None None XRAY 2.6 0.194 0.246 A 386 346 14 0 0 14 [[26, 321]] 1.0 2xs0 Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.5e-83 284.9 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 4UX9A P45983 8 363 427.0 ANP:1000 ATPlike Inactive DFGin 6.508 13.598 ABAminus -106.9, -65.56 -75.5, 125.74 -123.36, 16.47 304.33, 124.23 -68.62, -34.25 in-out in 8.85 Saltbr-out 3.673 HRD-in -62.88, -46.37 73.76, -28.18 out-in-in SNCoii in-in ActLoopNT-in 2.694 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -77.3, -23.46 APE9-dihe-na -71.58, 140.2 APE8-dihe-in -64.86, 127.48 APE8-rot-in 308.5 APE67-dihe-in -60.43, -26.76 -33.69, -61.49 APE12-dist-in 11.784 APE11-dist-in 12.426 APE10-dist-in 6.631 APE9-dist-in 4.533 None None None XRAY 2.34 0.202 0.24 A 364 343 7 0 0 5 [[26, 321]] 1.0 4ux9 Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 4UX9C P45983 8 363 427.0 ANP:1000 ATPlike Inactive DFGin 6.956 13.776 ABAminus -110.49, -64.95 -89.1, 120.63 -119.14, 21.23 309.02, 115.06 -68.23, -26.49 in-out in 8.919 Saltbr-out 3.636 HRD-in -66.22, -47.15 71.23, -16.82 out-in-none SNCoin in-none ActLoopNT-in 2.569 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -79.69, -26.4 APE9-dihe-na -76.07, 142.18 APE8-dihe-in -66.37, 127.01 APE8-rot-in 305.02 APE67-dihe-in -64.57, -24.76 -35.27, -55.26 APE12-dist-none 999.0 APE11-dist-in 12.005 APE10-dist-in 6.53 APE9-dist-in 4.621 None None None XRAY 2.34 0.202 0.24 C 364 333 15 0 0 7 [[26, 321]] 1.0 4ux9 Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 4UX9D P45983 9 364 427.0 ANP:1000 ATPlike Inactive DFGin 6.755 13.406 ABAminus -120.6, -55.98 -93.07, 108.1 -98.68, 25.97 301.07, 117.04 -64.8, -33.9 in-in in 9.366 Saltbr-in 2.738 HRD-in -59.8, -49.61 70.57, -12.64 in-in-out SNCiio in-out ActLoopNT-in 2.67 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oioo APE10-dihe-na -95.31, 105.19 APE9-dihe-na -74.34, -56.46 APE8-dihe-in -76.71, 134.72 APE8-rot-out 95.68 APE67-dihe-out -66.63, -26.9 -139.86, 50.27 APE12-dist-out 14.031 APE11-dist-in 13.438 APE10-dist-out 10.823 APE9-dist-out 13.555 None None None XRAY 2.34 0.202 0.24 D 364 344 9 0 0 0 [[26, 321]] 1.0 4ux9 Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 8R5EA P45983 5 363 427.0 ANP:402,Y6K:403 ATPlike,Allosteric Inactive DFGin 4.215 13.884 ABAminus -92.07, -26.65 -133.67, 178.16 -123.93, 6.5 294.94, 97.33 89.15, -162.77 in-out in 9.521 Saltbr-out 4.842 HRD-in -77.17, -59.97 76.05, -10.25 out-out-out SNCooo out-out ActLoopNT-out 6.79 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -62.14, 143.17 APE9-dihe-na -120.32, 118.65 APE8-dihe-in -75.39, 123.94 APE8-rot-in 299.29 APE67-dihe-in -61.41, -23.9 -115.12, 4.11 APE12-dist-out 18.707 APE11-dist-out 15.325 APE10-dist-out 16.68 APE9-dist-out 11.244 None None None XRAY 1.7 0.177 0.222 A 366 359 0 0 0 0 [[26, 321]] 1.0 8r5e Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 4QTDA P45983 6 363 427.0 38Z:424,ANP:425 Type1,Allosteric Inactive DFGin 4.279 13.95 ABAminus -89.69, -21.2 -135.34, 171.77 -115.48, 9.24 298.02, 89.8 87.52, -156.74 in-out in 9.593 Saltbr-out 4.153 HRD-in -75.36, -55.62 72.51, -12.26 out-out-out SNCooo out-out ActLoopNT-out 6.689 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -117.32, 137.81 APE9-dihe-na -80.42, 132.23 APE8-dihe-in -83.54, 120.1 APE8-rot-in 296.41 APE67-dihe-in -61.39, -20.52 -109.55, -3.05 APE12-dist-out 21.14 APE11-dist-out 16.032 APE10-dist-out 16.517 APE9-dist-out 11.147 None None None XRAY 1.5 0.167 0.192 A 364 355 3 0 0 3 [[26, 321]] 1.0 4qtd Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 9FT9A P45983 7 363 427.0 ANP:401 ATPlike Inactive DFGin 6.201 13.681 BLAminus -138.37, -170.04 58.94, 78.24 -92.66, 22.82 315.32, 103.73 -63.89, -26.18 in-out in 8.542 Saltbr-out 3.842 HRD-in -66.92, -47.02 65.13, 0.51 out-in-out SNCoio in-out ActLoopNT-in 2.827 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -150.17, 156.5 APE9-dihe-na -75.27, -52.01 APE8-dihe-in -88.35, 100.07 APE8-rot-in 310.81 APE67-dihe-in -64.72, -11.39 -102.84, 1.94 APE12-dist-out 5.91 APE11-dist-in 10.581 APE10-dist-out 8.079 APE9-dist-out 10.949 None None None XRAY 2.35 0.234 0.27 A 360 357 0 0 0 0 [[26, 321]] 1.0 9ft9 Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.1e-84 288.2 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 4UX9B P45983 8 362 427.0 ANP:1000 ATPlike Inactive DFGin 6.827 14.001 None -95.23, -79.97 -82.17, 124.02 -113.22, 13.68 297.81, 107.19 -60.29, -32.64 in-in in 8.603 Saltbr-in 2.942 HRD-in -59.44, -53.0 79.08, -24.85 in-in-in SNCiii in-in ActLoopNT-in 2.582 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -58.47, -40.48 APE9-dihe-na -78.17, 138.93 APE8-dihe-in -64.59, 122.35 APE8-rot-in 308.57 APE67-dihe-in -67.83, -19.56 -32.59, -57.13 APE12-dist-in 12.361 APE11-dist-in 12.149 APE10-dist-in 6.527 APE9-dist-in 4.691 None None None XRAY 2.34 0.202 0.24 B 364 327 14 0 0 6 [[26, 321]] 1.0 4ux9 Homo sapiens CMGC_MAPK8_HUMAN CMGC 4.3e-84 288.2 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC PRP4K PRP4K_HUMAN 4IIRA Q13523 668 1005 1007.0 ANP:1101 ATPlike Inactive DFGin 6.315 14.281 BLAminus -120.02, 179.88 56.46, 83.55 -99.74, 23.13 289.68, 86.8 -67.87, -30.41 in-in in 8.339 Saltbr-in 2.91 HRD-in -69.64, -43.63 60.41, 19.82 in-in-out SNCiio in-out ActLoopNT-in 2.778 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -71.08, 135.09 APE9-dihe-na 76.0, 140.17 APE8-dihe-in -53.9, 125.75 APE8-rot-in 292.63 APE67-dihe-in -65.92, -24.69 -31.89, -51.26 APE12-dist-out 15.663 APE11-dist-in 11.805 APE10-dist-out 8.892 APE9-dist-in 3.194 None PTR849 PTR849 XRAY 2.0 0.244 0.265 A 358 326 12 0 0 0 [[687, 1003]] 1.0 4iir Homo sapiens CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
CMGC PRP4K PRP4K_HUMAN 4IIRB Q13523 670 1005 1007.0 ANP:1101 ATPlike Inactive DFGin 6.312 13.999 BLAminus -118.84, -178.78 57.41, 86.51 -103.95, 25.37 293.04, 89.03 -68.57, -33.53 in-in in 8.481 Saltbr-in 2.795 HRD-in -68.12, -42.18 57.06, 24.08 in-in-out SNCiio in-out ActLoopNT-in 2.804 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -73.62, 140.27 APE9-dihe-na 75.42, 141.56 APE8-dihe-in -56.4, 124.9 APE8-rot-in 292.41 APE67-dihe-in -64.45, -24.58 -31.45, -51.6 APE12-dist-out 15.602 APE11-dist-in 11.812 APE10-dist-out 8.604 APE9-dist-in 3.219 None PTR849 PTR849 XRAY 2.0 0.244 0.265 B 358 328 8 0 0 0 [[687, 1003]] 1.0 4iir Homo sapiens CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
CMGC SRPK1 SRPK1_HUMAN 3BEGA Q96SB4 69 655 655.0 ANP:656 ATPlike Inactive DFGin 5.24 13.846 BLAminus -114.77, -153.39 33.98, 76.85 -81.15, -2.34 268.31, 108.69 -69.77, 18.55 in-none in 9.999 Saltbr-none 999.0 HRD-in -104.12, -37.12 72.24, -11.76 none-in-out SNCnio in-out ActLoopNT-in 3.285 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -116.54, 166.61 APE9-dihe-na 69.15, 140.92 APE8-dihe-in -77.27, 142.01 APE8-rot-out 16.0 APE67-dihe-in -60.83, 1.46 -31.99, -68.49 APE12-dist-in 12.995 APE11-dist-in 10.441 APE10-dist-in 7.835 APE9-dist-in 3.062 None None None XRAY 2.9 0.24 0.298 A 381 348 21 0 0 0 [[80, 653]] 1.0 3beg Homo sapiens CMGC_SRPK1_HUMAN CMGC 1.7e-139 470.1 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
OTHER EIF2AK2 E2AK2_HUMAN 2A19B P19525 258 541 551.0 ANP:61640 ATPlike Inactive DFGin 6.285 14.335 ABAminus -120.94, -28.83 -115.8, 107.84 -103.04, 22.08 287.72, 80.44 -61.97, -26.4 in-in in 8.248 Saltbr-in 2.731 HRD-in -80.45, -51.29 75.68, -7.45 in-in-out SNCiio in-out ActLoopNT-in 3.061 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -131.92, 139.76 APE9-dihe-na 107.67, -147.72 APE8-dihe-in -73.7, 128.56 APE8-rot-out 9.97 APE67-dihe-in -50.1, -40.95 -103.24, -6.7 APE12-dist-in 12.545 APE11-dist-in 10.841 APE10-dist-out 10.336 APE9-dist-out 9.852 H412N,C551A TPO446 TPO446 XRAY 2.5 0.234 0.286 B 284 262 9 0 0 0 [[175, 537]] 1.0 2a19 Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 6.2e-47 166.4 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 2A19C P19525 258 541 551.0 ANP:62640 ATPlike Inactive DFGin 6.941 14.558 ABAminus -118.27, -31.05 -99.56, 112.7 -116.24, 24.93 286.16, 84.97 -61.15, -35.53 in-in in 7.696 Saltbr-in 3.422 HRD-out -95.69, 102.36 -63.67, -30.07 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 H412N,C551A TPO446 TPO446 XRAY 2.5 0.234 0.286 C 284 202 69 0 0 22 [[175, 537]] 1.0 2a19 Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 6.2e-47 166.4 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER TP53RK PRPK_HUMAN 6WQXC Q96S44 17 247 253.0 ANP:301 ATPlike Active DFGin 5.95 14.251 BLAminus -146.19, 177.42 55.9, 80.94 -109.82, 15.46 288.95, 83.65 -50.48, -21.92 in-in in 7.493 Saltbr-in 2.923 HRD-in -69.98, -47.0 96.04, -14.43 in-in-na SNCiia in-na ActLoopNT-in 2.804 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -67.54, -42.02 APE9-dihe-na -66.2, -40.19 APE8-dihe-na -55.79, -43.62 APE8-rot-na 183.14 APE67-dihe-na -65.72, -35.03 -54.78, -48.19 APE12-dist-na 16.724 APE11-dist-na 12.036 APE10-dist-na 14.577 APE9-dist-na 11.741 None None None XRAY 2.53 0.214 0.265 C 267 231 6 0 0 0 [[32, 253]] 1.0 6wqx Homo sapiens OTHER_TP53RK_HUMAN TP53RK 1.2e-114 387.3 1 224 224 182 183 184 186 188 60 84 88 159 161 160 162 199 205 200 199 198 197 196 195 194 114 EKC/KEOPS complex subunit TP53RK
OTHER TP53RK PRPK_HUMAN 6WQXD Q96S44 18 247 253.0 ANP:301 ATPlike Active DFGin 6.043 14.258 BLAminus -133.24, 171.19 66.42, 73.64 -108.34, 16.47 289.91, 91.17 -66.2, -15.73 in-in in 7.377 Saltbr-in 2.505 HRD-in -60.03, -49.96 100.64, -20.8 in-in-na SNCiia in-na ActLoopNT-in 2.816 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -66.35, -39.45 APE9-dihe-na -58.51, -49.84 APE8-dihe-na -58.36, -37.8 APE8-rot-na 168.78 APE67-dihe-na -71.45, -37.84 -63.19, -40.46 APE12-dist-na 16.676 APE11-dist-na 12.07 APE10-dist-na 14.499 APE9-dist-na 11.469 None None None XRAY 2.53 0.214 0.265 D 267 230 6 0 0 0 [[32, 253]] 1.0 6wqx Homo sapiens OTHER_TP53RK_HUMAN TP53RK 1.2e-114 387.3 1 224 224 182 183 184 186 188 60 84 88 159 161 160 162 199 205 200 199 198 197 196 195 194 114 EKC/KEOPS complex subunit TP53RK
OTHER WNK1 WNK1_HUMAN 5WDYA Q9H4A3 208 481 2382.0 ANP:901,A6S:902 ATPlike,Type3 None DFGin 7.965 14.31 BLAminus -123.5, -167.41 55.36, 79.67 -97.29, 28.92 280.94, 63.73 -64.29, -44.25 na-na na 15.412 Saltbr-na 999.0 HRD-in -68.16, -49.86 71.58, -14.71 na-in-none SNCain in-none ActLoopNT-in 3.014 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -108.13, -60.96 999.0, 157.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S378D,E396A,E397A,K398A None None XRAY 2.458 0.231 0.285 A 279 260 14 0 0 9 [[220, 479]] 1.0 5wdy Homo sapiens OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1 260 260 367 368 369 371 373 250 268 272 346 348 347 349 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 5WDYB Q9H4A3 206 480 2382.0 ANP:502,A6S:503 ATPlike,Type3 Inactive DFGin 7.37 14.504 BLAminus -142.95, -168.2 54.59, 81.56 -95.94, 38.03 311.01, 0.7 -70.23, -38.22 na-na na 15.664 Saltbr-na 999.0 HRD-in -73.48, -49.35 66.41, -10.51 na-in-out SNCaio in-out ActLoopNT-in 2.856 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -28.04 APE8-rot-out 62.13 APE67-dihe-out -96.17, -54.53 -53.63, 160.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S378D,E396A,E397A,K398A None None XRAY 2.458 0.231 0.285 B 279 259 16 0 0 9 [[220, 479]] 1.0 5wdy Homo sapiens OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1 260 260 367 368 369 371 373 250 268 272 346 348 347 349 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 5WE8A Q9H4A3 209 483 2382.0 ANP:502,A7Y:503 ATPlike,Type3 Inactive DFGin 7.241 14.032 BLAminus -121.41, -171.4 57.02, 71.32 -89.03, 25.94 306.74, 15.86 -67.83, -33.81 na-na na 15.506 Saltbr-na 999.0 HRD-in -66.1, -48.39 70.94, -12.37 na-in-out SNCaio in-out ActLoopNT-in 2.847 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -77.54, 145.45 APE9-dihe-na 132.01, 166.25 APE8-dihe-in -145.73, 139.85 APE8-rot-out 178.66 APE67-dihe-out -92.59, -40.75 -69.19, 149.7 APE12-dist-out 20.134 APE11-dist-out 22.408 APE10-dist-out 25.402 APE9-dist-out 25.928 S378D,E396A,E397A,K398A None None XRAY 2.006 0.205 0.247 A 279 270 5 0 0 0 [[220, 479]] 1.0 5we8 Homo sapiens OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1 260 260 367 368 369 371 373 250 268 272 346 348 347 349 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 5WE8B Q9H4A3 207 480 2382.0 ANP:502,A7Y:503 ATPlike,Type3 Inactive DFGin 7.576 14.733 BLAminus -124.5, -174.3 56.61, 76.82 -93.57, 20.89 272.49, 56.06 -64.65, -35.23 na-na na 15.252 Saltbr-na 999.0 HRD-in -64.68, -49.22 72.3, -10.07 na-in-out SNCaio in-out ActLoopNT-in 2.82 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -86.7, 136.01 APE9-dihe-na 147.23, 150.88 APE8-dihe-in -131.74, 126.21 APE8-rot-in 297.77 APE67-dihe-out -91.94, -28.57 -59.79, 145.49 APE12-dist-out 19.935 APE11-dist-out 22.726 APE10-dist-out 25.875 APE9-dist-out 25.614 S378D,E396A,E397A,K398A None None XRAY 2.006 0.205 0.247 B 279 272 2 0 0 0 [[220, 479]] 1.0 5we8 Homo sapiens OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1 260 260 367 368 369 371 373 250 268 272 346 348 347 349 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 5TF9A Q9H4A3 210 483 2382.0 7AV:501,ANP:502 Type3,ATPlike Inactive DFGin 7.799 14.806 BLAminus -124.68, -165.52 44.5, 74.88 -89.64, 28.71 274.12, 71.89 -66.6, -24.41 na-na na 15.637 Saltbr-na 999.0 HRD-in -62.68, -52.45 73.71, -6.51 na-in-out SNCaio in-out ActLoopNT-in 2.868 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 175.52 APE8-dihe-in -127.14, 129.36 APE8-rot-out 176.04 APE67-dihe-out -84.82, -53.84 -65.86, 145.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 27.092 None None None XRAY 2.5 0.198 0.266 A 279 262 12 0 0 9 [[220, 479]] 1.0 5tf9 Homo sapiens OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1 260 260 367 368 369 371 373 250 268 272 346 348 347 349 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_HUMAN 5TF9B Q9H4A3 206 480 2382.0 7AV:501,ANP:502 Type3,ATPlike Inactive DFGin 7.745 14.581 BLAminus -133.01, -172.41 51.04, 69.52 -83.58, 20.61 265.53, 72.73 -66.77, -27.15 na-na na 14.861 Saltbr-na 999.0 HRD-in -69.24, -45.67 70.25, -7.52 na-in-out SNCaio in-out ActLoopNT-in 2.902 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -166.32 APE8-dihe-in -143.09, 133.87 APE8-rot-in 278.07 APE67-dihe-out -99.53, -28.5 -65.98, 144.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 26.599 None None None XRAY 2.5 0.198 0.266 B 279 266 9 0 0 9 [[220, 479]] 1.0 5tf9 Homo sapiens OTHER_WNK1_HUMAN WNK 1.9e-177 593.7 1 260 260 367 368 369 371 373 250 268 272 346 348 347 349 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK3 WNK3_HUMAN 5O26A Q9BYP7 135 414 1800.0 ANP:501 ATPlike Active DFGin 6.954 12.201 BLAminus -125.28, -164.72 58.79, 65.89 -88.2, 18.66 305.61, 176.73 -69.56, -20.03 na-na na 15.898 Saltbr-na 999.0 HRD-in -66.1, -48.87 66.45, 11.22 na-in-in SNCaii in-in ActLoopNT-in 3.021 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.2, 167.0 APE9-dihe-na 127.63, -163.54 APE8-dihe-in -104.53, 119.98 APE8-rot-in 309.3 APE67-dihe-in -64.09, -19.44 -52.49, -34.59 APE12-dist-in 8.873 APE11-dist-in 11.829 APE10-dist-in 6.326 APE9-dist-in 3.706 None SEP304,SEP308 SEP304,SEP308 XRAY 2.379 0.231 0.278 A 284 273 7 0 0 0 [[146, 405]] 1.0 5o26 Homo sapiens OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
OTHER WNK3 WNK3_HUMAN 5O26B Q9BYP7 136 413 1800.0 ANP:501 ATPlike Active DFGin 7.182 12.078 BLAminus -111.0, -167.63 57.49, 63.76 -86.7, 17.71 307.84, 173.05 -70.2, -27.96 na-na na 15.641 Saltbr-na 999.0 HRD-in -66.99, -53.82 74.22, 8.4 na-in-in SNCaii in-in ActLoopNT-in 3.073 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.41, 145.08 APE9-dihe-na 140.9, -162.45 APE8-dihe-in -99.46, 120.61 APE8-rot-in 305.94 APE67-dihe-in -65.71, -19.72 -54.06, -31.08 APE12-dist-in 8.136 APE11-dist-in 11.827 APE10-dist-in 6.044 APE9-dist-in 3.51 None SEP304,SEP308 SEP304,SEP308 XRAY 2.379 0.231 0.278 B 284 267 11 0 0 0 [[146, 405]] 1.0 5o26 Homo sapiens OTHER_WNK3_HUMAN WNK 2.6e-178 596.6 1 260 260 293 294 295 297 299 176 194 198 272 274 273 275 330 319 314 313 312 311 310 309 308 228 Serine/threonine-protein kinase WNK3
STE MAP2K1 MP2K1_HUMAN 5YT3C Q02750 40 382 393.0 ANP:401 ATPlike Inactive DFGin 5.791 13.739 BLBplus -158.87, 169.48 60.29, 28.47 -79.68, 102.42 54.67, 117.74 -64.84, 999.0 out-none out 15.495 Saltbr-none 999.0 HRD-in -68.06, -45.57 70.46, -13.87 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 133.64 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S218D,S222D,T292A,S298A None None XRAY 2.9 0.213 0.289 C 350 288 55 0 0 17 [[68, 361]] 1.0 5yt3 Homo sapiens STE_MAP2K1_HUMAN STE 4.7e-97 330.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 6V2WB Q02750 40 383 393.0 ANP:801 ATPlike Inactive DFGin 5.839 13.801 BLBplus -157.59, 169.08 49.06, 44.93 -84.24, 160.32 41.65, 89.8 -73.89, 81.99 out-out out 15.498 Saltbr-out 15.901 HRD-in -69.45, -57.02 68.3, 7.65 out-out-out SNCooo out-out ActLoopNT-out 8.701 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -54.4, 144.31 APE9-dihe-na -89.17, -161.86 APE8-dihe-out -115.14, -20.62 APE8-rot-out 48.82 APE67-dihe-out -139.36, 135.26 -146.31, 162.2 APE12-dist-out 17.533 APE11-dist-out 22.736 APE10-dist-out 24.016 APE9-dist-out 13.645 S218A,S222A None None XRAY 3.12 0.189 0.237 B 397 312 32 0 0 0 [[68, 361]] 1.0 6v2w Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3SLSA Q02750 45 383 393.0 ANP:60400,77D:60500 ATPlike,Type3 Inactive DFGin 6.067 13.828 BLBplus -140.19, 178.66 54.09, 43.7 -94.25, 127.95 47.57, 97.28 -65.93, 145.27 out-out out 15.765 Saltbr-out 16.219 HRD-in -71.97, -60.22 78.51, -3.12 out-out-out SNCooo out-out ActLoopNT-out 8.437 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nooo APE10-dihe-na -93.38, -0.96 APE9-dihe-na -118.58, -150.08 APE8-dihe-out -118.64, -9.13 APE8-rot-out 48.38 APE67-dihe-out -141.57, 136.87 -142.17, 156.77 APE12-dist-none 999.0 APE11-dist-out 20.727 APE10-dist-out 20.295 APE9-dist-out 13.917 None None None XRAY 2.3 0.21 0.287 A 304 288 7 0 0 6 [[68, 361]] 1.0 3sls Homo sapiens STE_MAP2K1_HUMAN STE 1.4e-98 335.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3SLSB Q02750 45 383 393.0 ANP:60400,77D:60500 ATPlike,Type3 Inactive DFGin 6.221 13.815 BLBplus -143.68, 175.58 56.27, 41.79 -94.32, 130.27 43.79, 91.06 -64.4, 146.65 out-out out 15.816 Saltbr-out 15.927 HRD-in -71.99, -58.98 74.88, -1.55 out-out-out SNCooo out-out ActLoopNT-out 7.506 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nooo APE10-dihe-na -110.34, -17.81 APE9-dihe-na 107.94, -164.16 APE8-dihe-out -114.29, -25.66 APE8-rot-out 168.01 APE67-dihe-out -146.37, 136.37 -123.32, 171.0 APE12-dist-none 999.0 APE11-dist-out 19.137 APE10-dist-out 21.303 APE9-dist-out 13.595 None None None XRAY 2.3 0.21 0.287 B 304 290 5 0 0 5 [[68, 361]] 1.0 3sls Homo sapiens STE_MAP2K1_HUMAN STE 1.4e-98 335.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B3MA Q02750 37 382 393.0 ANP:60402,SU5:60403 ATPlike,Type3 Inactive DFGin 6.126 13.37 BLBplus -148.65, 168.81 60.69, 38.17 -87.91, 154.07 39.86, 88.52 -71.49, 59.19 out-out out 15.314 Saltbr-out 14.994 HRD-in -70.73, -50.42 71.08, -9.53 out-out-out SNCooo out-out ActLoopNT-out 8.955 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -121.3 APE8-dihe-out -86.65, -7.6 APE8-rot-out 192.68 APE67-dihe-out -130.89, 138.61 -149.99, 133.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.675 None None None XRAY 2.3 0.22 0.268 A 326 297 5 0 0 5 [[68, 361]] 1.0 7b3m Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B3MB Q02750 37 382 393.0 ANP:60402,SU5:60403 ATPlike,Type3 Inactive DFGin 6.095 13.35 BLBplus -147.84, 168.76 59.95, 38.27 -86.94, 152.02 37.7, 89.9 -70.97, 59.7 out-out out 15.264 Saltbr-out 14.844 HRD-in -70.51, -50.26 71.48, -11.7 out-out-out SNCooo out-out ActLoopNT-out 8.913 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -133.25 APE8-dihe-out -83.19, -28.76 APE8-rot-in 262.25 APE67-dihe-out -150.63, 137.62 -127.52, 158.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.084 None None None XRAY 2.3 0.22 0.268 B 326 298 4 0 0 4 [[68, 361]] 1.0 7b3m Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B7RA Q02750 37 382 393.0 ANP:60401,T1K:60403 ATPlike,Type3 Inactive DFGin 6.142 13.168 BLBplus -135.79, 174.07 60.45, 39.3 -91.52, 155.87 43.71, 91.25 -77.25, 65.03 out-out out 15.299 Saltbr-out 15.464 HRD-in -68.45, -57.29 78.52, -6.73 out-out-out SNCooo out-out ActLoopNT-out 8.935 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -104.92 APE8-dihe-out -68.21, -24.42 APE8-rot-out 184.14 APE67-dihe-out -122.45, 137.43 -138.43, 139.59 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.332 None None None XRAY 1.7 0.195 0.218 A 326 297 5 0 0 5 [[68, 361]] 1.0 7b7r Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B7RB Q02750 39 382 393.0 ANP:60401,T1K:60403 ATPlike,Type3 Inactive DFGin 6.034 13.131 BLBplus -135.72, 177.16 59.39, 36.14 -85.12, 154.58 37.29, 94.77 -80.68, 71.22 out-out out 15.295 Saltbr-out 15.378 HRD-in -70.94, -55.67 77.08, -4.68 out-out-out SNCooo out-out ActLoopNT-out 8.9 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -49.75 APE8-rot-out 171.35 APE67-dihe-out -144.02, 141.19 -140.4, 157.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.195 0.218 B 326 295 5 0 0 5 [[68, 361]] 1.0 7b7r Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B94A Q02750 37 382 393.0 ANP:60401,T3W:60403 ATPlike,Type3 Inactive DFGin 5.992 13.478 BLBplus -132.63, 177.07 57.77, 37.37 -87.97, 156.39 42.38, 94.42 -75.9, 68.49 out-out out 15.532 Saltbr-out 15.193 HRD-in -65.24, -55.1 71.13, -2.53 out-out-out SNCooo out-out ActLoopNT-out 8.887 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 176.47 APE8-dihe-out -89.38, 6.07 APE8-rot-in 312.59 APE67-dihe-out -115.47, 140.44 -116.58, 113.1 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.599 None None None XRAY 2.0 0.218 0.265 A 326 297 5 0 0 5 [[68, 361]] 1.0 7b94 Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B94B Q02750 41 382 393.0 ANP:60401,T3W:60403 ATPlike,Type3 Inactive DFGin 5.853 13.51 BLBplus -134.32, 175.36 55.61, 39.25 -86.46, 153.65 39.68, 92.62 -72.74, 66.29 out-out out 15.117 Saltbr-out 14.548 HRD-in -66.3, -53.58 77.63, -11.98 out-out-out SNCooo out-out ActLoopNT-out 8.617 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -40.61 APE8-rot-out 185.17 APE67-dihe-out -147.87, 139.4 -127.59, 154.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.218 0.265 B 326 293 5 0 0 5 [[68, 361]] 1.0 7b94 Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B9LA Q02750 37 382 393.0 ANP:60401,T4N:60402 ATPlike,Type3 Inactive DFGin 6.143 13.385 BLBplus -137.56, 174.87 57.48, 45.06 -95.99, 156.93 43.03, 91.55 -78.34, 66.31 out-out out 15.272 Saltbr-out 15.243 HRD-in -67.86, -56.92 79.15, -7.52 out-out-none SNCoon out-none ActLoopNT-out 8.968 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -119.38, 141.01 999.0, 135.92 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.194 0.214 A 326 295 7 0 0 7 [[68, 361]] 1.0 7b9l Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7B9LB Q02750 41 381 393.0 ANP:60401,T4N:60402 ATPlike,Type3 Inactive DFGin 5.958 13.456 BLBplus -136.66, 175.43 56.67, 43.08 -92.39, 158.5 42.85, 91.66 -74.84, 62.99 out-out out 15.156 Saltbr-out 14.936 HRD-in -69.72, -56.61 80.29, -8.28 out-out-none SNCoon out-none ActLoopNT-out 8.692 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -146.85, 137.07 999.0, 132.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.194 0.214 B 326 291 6 0 0 6 [[68, 361]] 1.0 7b9l Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-98 335.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3ORNA Q02750 62 380 393.0 ANP:60001,3OR:60400 ATPlike,Type3 Inactive DFGin 6.029 13.804 BLBplus -141.26, -171.81 51.14, 43.91 -94.56, 165.92 40.22, 96.28 -82.7, 73.49 out-out out 15.345 Saltbr-out 15.245 HRD-in -75.72, -51.63 76.11, -2.33 out-out-out SNCooo out-out ActLoopNT-out 9.248 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -90.01, 161.45 APE9-dihe-na 75.09, 172.06 APE8-dihe-out -101.08, -27.15 APE8-rot-out 71.34 APE67-dihe-out -133.03, 139.32 -108.61, 153.73 APE12-dist-out 16.856 APE11-dist-out 20.622 APE10-dist-out 18.566 APE9-dist-out 13.045 None None None XRAY 2.8 0.236 0.277 A 307 279 8 0 0 0 [[68, 361]] 1.0 3orn Homo sapiens STE_MAP2K1_HUMAN STE 9.7e-99 335.8 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3WIGA Q02750 62 380 393.0 ANP:60401,CHU:60403 ATPlike,Type3 Inactive DFGin 6.265 14.016 BLBplus -143.18, 168.24 57.0, 43.27 -87.61, 167.58 35.17, 91.44 -81.11, 80.9 out-out out 15.223 Saltbr-out 15.235 HRD-in -81.12, -52.72 78.66, -9.66 out-out-out SNCooo out-out ActLoopNT-out 9.252 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -106.56, 160.96 APE9-dihe-na 79.87, 168.49 APE8-dihe-out -95.77, -24.16 APE8-rot-out 58.57 APE67-dihe-out -134.06, 137.9 -112.83, 153.13 APE12-dist-out 16.507 APE11-dist-out 20.149 APE10-dist-out 18.501 APE9-dist-out 12.948 None None None XRAY 2.7 0.217 0.25 A 307 277 10 0 0 0 [[68, 361]] 1.0 3wig Homo sapiens STE_MAP2K1_HUMAN STE 9.7e-99 335.8 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4U80A Q02750 62 379 393.0 ANP:60501,3EX:60502 ATPlike,Type3 Inactive DFGin 6.142 13.358 BLBplus -137.92, -179.3 57.25, 41.8 -100.21, 164.46 49.55, 87.81 -82.1, 69.9 out-out out 15.391 Saltbr-out 16.174 HRD-in -63.5, -60.19 86.1, -12.96 out-out-out SNCooo out-out ActLoopNT-out 9.174 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnoo APE10-dihe-na 999.0, -56.89 APE9-dihe-na 91.88, -152.59 APE8-dihe-out -126.68, 10.89 APE8-rot-in 310.84 APE67-dihe-out -98.05, 140.26 -155.43, 115.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.557 APE9-dist-out 13.427 None None None XRAY 2.8 0.167 0.224 A 341 285 33 0 0 3 [[68, 361]] 1.0 4u80 Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4LMNA Q02750 62 382 393.0 ANP:60501,EUI:60503 ATPlike,Type3 Inactive DFGin 6.109 13.407 BLBplus -150.33, -178.45 56.52, 30.25 -84.69, 155.37 45.37, 87.33 -80.58, 74.43 out-out out 15.56 Saltbr-out 15.776 HRD-in -60.71, -57.05 86.56, -12.8 out-out-out SNCooo out-out ActLoopNT-out 9.013 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -106.36, -106.55 APE9-dihe-na -110.69, -4.9 APE8-dihe-out -94.39, -2.53 APE8-rot-out 38.79 APE67-dihe-out -120.37, 128.01 -144.86, 111.2 APE12-dist-out 20.474 APE11-dist-out 19.732 APE10-dist-out 22.049 APE9-dist-out 15.311 None None None XRAY 2.8 0.193 0.233 A 341 291 30 0 0 0 [[68, 361]] 1.0 4lmn Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7UMBC Q02750 41 381 393.0 ANP:401,U9F:402 ATPlike,Type3 Inactive DFGin 6.169 13.767 BLBplus -162.24, 171.11 70.21, 49.7 -113.95, 160.88 44.65, 94.08 -79.06, 81.13 out-out out 15.559 Saltbr-out 15.273 HRD-in -66.12, -48.09 76.83, -9.86 out-out-out SNCooo out-out ActLoopNT-out 9.591 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -127.94, 139.36 APE9-dihe-na -138.86, -160.81 APE8-dihe-out -82.2, -18.64 APE8-rot-out 50.9 APE67-dihe-out -106.39, 139.13 -104.8, 110.61 APE12-dist-out 16.699 APE11-dist-out 19.666 APE10-dist-out 21.57 APE9-dist-out 14.915 None None None XRAY 3.231 0.231 0.268 C 384 303 38 0 0 0 [[68, 361]] 1.0 7umb Homo sapiens STE_MAP2K1_HUMAN STE 2.3e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 6PP9B Q02750 38 383 393.0 ANP:801,LCJ:803 ATPlike,Type3 Inactive DFGin 6.051 13.85 BLBplus -152.52, 171.62 57.53, 41.01 -92.48, 164.33 45.1, 87.01 -81.4, 67.83 out-out out 15.469 Saltbr-out 15.325 HRD-in -69.19, -57.7 73.02, -1.06 out-out-out SNCooo out-out ActLoopNT-out 8.325 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -150.75, 155.46 APE9-dihe-na -104.35, -179.3 APE8-dihe-out -103.86, -21.71 APE8-rot-out 60.0 APE67-dihe-out -161.36, 138.21 -120.01, -175.99 APE12-dist-out 17.629 APE11-dist-out 18.098 APE10-dist-out 21.191 APE9-dist-out 12.184 S218A,S222A None None XRAY 2.59 0.222 0.245 B 397 314 32 0 0 0 [[68, 361]] 1.0 6pp9 Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0VB Q02750 42 383 393.0 ANP:801,EUI:803 ATPlike,Type3 Inactive DFGin 6.038 13.738 BLBplus -152.98, 176.74 51.89, 40.05 -97.58, 155.01 48.54, 94.68 -74.32, 76.65 out-out out 15.356 Saltbr-out 15.248 HRD-in -53.62, -41.23 79.48, -8.01 out-out-out SNCooo out-out ActLoopNT-out 8.451 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -59.78, 136.18 APE9-dihe-na -90.07, -164.06 APE8-dihe-out -111.55, -13.91 APE8-rot-out 80.18 APE67-dihe-out -157.27, 123.12 -113.49, 175.2 APE12-dist-out 17.753 APE11-dist-out 19.587 APE10-dist-out 21.216 APE9-dist-out 13.438 S218A,S222A None None XRAY 3.16 0.188 0.234 B 397 310 32 0 0 0 [[68, 361]] 1.0 7m0v Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0WB Q02750 42 383 393.0 ANP:801,QOA:803 ATPlike,Type3 Inactive DFGin 6.148 14.055 BLBplus -157.1, -177.15 57.47, 39.21 -94.37, 139.97 49.64, 89.26 -60.24, 75.28 out-out out 15.239 Saltbr-out 15.181 HRD-in -60.24, -53.72 67.58, 4.61 out-out-out SNCooo out-out ActLoopNT-out 8.866 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -57.72, 142.94 APE9-dihe-na -85.2, -169.93 APE8-dihe-out -102.45, -22.28 APE8-rot-out 37.77 APE67-dihe-out -129.82, 144.3 -151.67, 158.88 APE12-dist-out 17.512 APE11-dist-out 22.657 APE10-dist-out 23.477 APE9-dist-out 13.59 S218A,S222A None None XRAY 3.09 0.197 0.233 B 397 310 32 0 0 0 [[68, 361]] 1.0 7m0w Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0XB Q02750 40 383 393.0 ANP:801,4BM:803 ATPlike,Type3 Inactive DFGin 6.04 13.707 BLBplus -145.13, 173.52 62.48, 32.29 -85.3, 166.26 43.84, 89.91 -82.62, 63.8 out-out out 15.219 Saltbr-out 15.128 HRD-in -57.93, -57.46 71.94, -0.74 out-out-out SNCooo out-out ActLoopNT-out 8.331 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -140.02, 147.44 APE9-dihe-na -87.47, -179.23 APE8-dihe-out -111.82, -15.11 APE8-rot-out 56.07 APE67-dihe-out -151.04, 140.91 -141.23, 175.81 APE12-dist-out 17.795 APE11-dist-out 17.919 APE10-dist-out 21.393 APE9-dist-out 11.986 S218A,S222A None None XRAY 2.47 0.18 0.215 B 397 312 32 0 0 0 [[68, 361]] 1.0 7m0x Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0YB Q02750 43 382 393.0 ANP:401,QOM:404 ATPlike,Type3 Inactive DFGin 5.931 13.967 BLBplus -158.94, 162.56 56.25, 36.06 -89.69, 147.0 54.27, 82.92 -67.13, 108.1 out-out out 15.493 Saltbr-out 15.962 HRD-in -58.74, -61.39 74.04, 6.51 out-out-out SNCooo out-out ActLoopNT-out 9.402 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -63.76, 140.76 APE9-dihe-na -82.11, -165.89 APE8-dihe-out -109.48, -23.44 APE8-rot-out 48.75 APE67-dihe-out -133.69, 134.38 -151.5, 158.4 APE12-dist-out 17.381 APE11-dist-out 22.453 APE10-dist-out 23.379 APE9-dist-out 13.66 S218A,S222A None None XRAY 3.45 0.196 0.218 B 397 308 32 0 0 0 [[68, 361]] 1.0 7m0y Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0ZB Q02750 42 383 393.0 ANP:401,CHU:402 ATPlike,Type3 Inactive DFGin 6.106 14.107 BLBplus -160.77, 175.85 59.87, 41.63 -97.41, 152.84 45.88, 80.73 -66.99, 92.55 out-out out 15.493 Saltbr-out 15.371 HRD-in -96.91, -40.79 69.65, -8.88 out-out-out SNCooo out-out ActLoopNT-out 9.612 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -66.4, 138.99 APE9-dihe-na -84.75, -165.15 APE8-dihe-out -106.74, -38.37 APE8-rot-out 38.19 APE67-dihe-out -129.38, 138.55 -136.73, 157.33 APE12-dist-out 17.213 APE11-dist-out 22.382 APE10-dist-out 23.613 APE9-dist-out 13.603 S218A,S222A None None XRAY 3.12 0.193 0.225 B 397 310 32 0 0 0 [[68, 361]] 1.0 7m0z Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXHA Q02750 39 381 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.113 14.205 BLBplus -138.52, 176.84 56.32, 45.26 -98.43, 166.79 48.45, 76.71 -79.29, 73.17 out-out out 15.389 Saltbr-out 15.461 HRD-in -79.27, -55.22 75.38, 2.3 out-out-out SNCooo out-out ActLoopNT-out 9.391 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -141.27, 126.74 APE9-dihe-na -91.23, -150.48 APE8-dihe-out -108.84, -16.83 APE8-rot-out 178.7 APE67-dihe-out -130.79, 128.8 -115.86, 151.78 APE12-dist-out 17.417 APE11-dist-out 17.624 APE10-dist-out 20.898 APE9-dist-out 13.154 None None None XRAY 2.81 0.206 0.253 A 310 299 0 0 0 0 [[68, 361]] 1.0 9axh Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-98 335.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXHB Q02750 38 381 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.028 13.959 BLBplus -143.4, 172.79 59.61, 49.11 -104.03, 163.1 47.48, 79.51 -74.37, 70.81 out-out out 15.415 Saltbr-out 14.817 HRD-in -76.49, -58.47 81.39, -4.23 out-out-out SNCooo out-out ActLoopNT-out 9.322 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -140.95, 129.53 APE9-dihe-na -95.7, -172.17 APE8-dihe-out -83.87, -23.26 APE8-rot-out 67.32 APE67-dihe-out -134.03, 129.22 -119.03, 156.34 APE12-dist-out 17.307 APE11-dist-out 17.575 APE10-dist-out 20.9 APE9-dist-out 12.718 None None None XRAY 2.81 0.206 0.253 B 310 300 0 0 0 0 [[68, 361]] 1.0 9axh Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-98 335.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXMA Q02750 38 382 393.0 A1AHE:60401,ANP:60403 Type1,ATPlike Inactive DFGin 6.204 13.999 BLBplus -146.84, 170.95 57.84, 58.3 -113.46, 158.4 47.1, 81.42 -71.93, 78.64 out-out out 15.426 Saltbr-out 15.513 HRD-in -80.25, -54.29 71.05, 3.5 out-out-out SNCooo out-out ActLoopNT-out 9.11 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -58.81, 135.38 APE9-dihe-na -86.44, -174.93 APE8-dihe-out -114.7, -19.48 APE8-rot-out 61.33 APE67-dihe-out -156.42, 133.96 -137.25, 175.14 APE12-dist-out 17.347 APE11-dist-out 22.123 APE10-dist-out 24.223 APE9-dist-out 13.241 S218A,S222A None None XRAY 2.42 0.263 0.301 A 310 301 0 0 0 0 [[68, 361]] 1.0 9axm Homo sapiens STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXXA Q02750 41 382 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.157 14.473 BLBplus -142.21, 167.57 61.94, 40.19 -92.82, 170.58 38.95, 89.02 -82.21, 74.48 out-out out 15.925 Saltbr-out 15.661 HRD-in -77.34, -56.94 85.02, -11.71 out-out-out SNCooo out-out ActLoopNT-out 9.623 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -70.01, 140.02 APE9-dihe-na -107.63, 178.58 APE8-dihe-out -103.64, -13.88 APE8-rot-out 56.98 APE67-dihe-out -152.18, 145.48 -132.34, 175.09 APE12-dist-out 18.633 APE11-dist-out 16.086 APE10-dist-out 21.091 APE9-dist-out 12.771 S218A,S222A None None XRAY 2.07 0.215 0.248 A 310 298 0 0 0 0 [[68, 361]] 1.0 9axx Homo sapiens STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXXC Q02750 37 378 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.066 14.251 BLBplus -153.34, 165.37 62.85, 41.08 -93.54, 164.6 44.67, 86.41 -75.31, 71.49 out-out out 15.517 Saltbr-out 15.022 HRD-in -80.68, -38.87 53.15, 7.3 out-out-out SNCooo out-out ActLoopNT-out 9.691 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -68.91, 127.09 APE9-dihe-na -100.27, 169.31 APE8-dihe-out -98.12, -23.61 APE8-rot-out 61.42 APE67-dihe-out -153.77, 146.66 -125.41, 178.29 APE12-dist-out 18.45 APE11-dist-out 16.119 APE10-dist-out 21.581 APE9-dist-out 12.749 S218A,S222A None None XRAY 2.07 0.215 0.248 C 310 297 1 0 0 0 [[68, 361]] 1.0 9axx Homo sapiens STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AYAB Q02750 42 382 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.209 14.117 BLBplus -156.4, 169.03 57.59, 47.08 -100.39, 159.82 46.95, 83.0 -73.48, 80.99 out-out out 15.444 Saltbr-out 14.957 HRD-in -72.22, -50.64 78.5, -7.92 out-out-out SNCooo out-out ActLoopNT-out 9.725 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -67.32, 133.53 APE9-dihe-na -94.07, -169.54 APE8-dihe-out -110.54, -56.8 APE8-rot-out 71.18 APE67-dihe-out -155.6, 139.89 -98.61, 175.74 APE12-dist-out 17.221 APE11-dist-out 22.149 APE10-dist-out 24.195 APE9-dist-out 13.766 S218A,S222A None None XRAY 2.59 0.214 0.257 B 310 297 0 0 0 0 [[68, 361]] 1.0 9aya Homo sapiens STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AYAD Q02750 39 382 393.0 A1AHE:60401,ANP:60402 Type1,ATPlike Inactive DFGin 6.236 14.114 BLBplus -150.42, 169.48 62.14, 35.37 -84.74, 166.85 39.42, 88.37 -83.08, 73.44 out-out out 15.382 Saltbr-out 15.287 HRD-in -84.82, -56.5 86.5, -11.08 out-out-out SNCooo out-out ActLoopNT-out 9.653 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 132.69 APE8-dihe-out -103.38, -24.48 APE8-rot-out 47.89 APE67-dihe-out -161.23, 135.82 -100.94, -174.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.749 S218A,S222A None None XRAY 2.59 0.214 0.257 D 310 293 7 0 0 3 [[68, 361]] 1.0 9aya Homo sapiens STE_MAP2K1_HUMAN STE 6.5e-98 333.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AY7B Q02750 33 383 393.0 A1AHE:401,ANP:402 Type1,ATPlike Inactive DFGin 6.131 14.268 BLBplus -154.96, 169.08 61.0, 36.72 -91.6, 162.02 49.73, 81.71 -77.61, 77.19 out-out out 15.513 Saltbr-out 15.402 HRD-in -75.89, -55.94 83.29, -11.88 out-out-out SNCooo out-out ActLoopNT-out 9.576 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -66.62, 136.57 APE9-dihe-na -89.93, -175.43 APE8-dihe-out -113.57, -10.62 APE8-rot-out 51.26 APE67-dihe-out -146.5, 144.85 -157.42, 170.13 APE12-dist-out 17.344 APE11-dist-out 22.114 APE10-dist-out 24.207 APE9-dist-out 13.729 S218A,S222A None None XRAY 2.41 0.203 0.236 B 394 322 29 0 0 0 [[68, 361]] 1.0 9ay7 Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0UH Q02750 30 380 393.0 CHU:401,ANP:402 Type1,ATPlike Inactive DFGin 6.226 14.24 BLBplus -153.68, 170.44 61.41, 47.24 -102.95, 164.39 45.69, 94.01 -79.55, 83.41 out-out out 15.581 Saltbr-out 15.785 HRD-in -74.86, -48.68 73.9, -6.25 out-out-out SNCooo out-out ActLoopNT-out 9.583 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -141.84, 152.52 APE9-dihe-na -130.16, 177.33 APE8-dihe-out -105.34, -25.09 APE8-rot-out 37.73 APE67-dihe-out -147.39, 136.35 -136.55, 176.51 APE12-dist-out 17.387 APE11-dist-out 17.659 APE10-dist-out 22.215 APE9-dist-out 12.997 S218A,S222A None None XRAY 2.91 0.232 0.264 H 395 315 36 0 0 0 [[68, 361]] 1.0 9o0u Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0VB Q02750 30 380 393.0 CHU:401,ANP:402 Type1,ATPlike Inactive DFGin 6.193 14.125 BLBplus -151.85, 167.5 59.4, 48.24 -102.03, 163.4 46.52, 86.88 -79.89, 84.21 out-out out 15.595 Saltbr-out 16.841 HRD-in -72.2, -48.2 74.46, -6.51 out-out-out SNCooo out-out ActLoopNT-out 9.706 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -135.59, 156.7 APE9-dihe-na -122.67, 146.4 APE8-dihe-out -101.77, -26.6 APE8-rot-in 280.72 APE67-dihe-out -147.98, 135.29 -136.69, 175.09 APE12-dist-out 16.923 APE11-dist-out 17.129 APE10-dist-out 21.862 APE9-dist-out 12.429 S218A,S222A None None XRAY 3.5 0.208 0.254 B 395 322 29 0 0 0 [[68, 361]] 1.0 9o0v Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0VH Q02750 30 380 393.0 CHU:401,ANP:402 Type1,ATPlike Inactive DFGin 6.349 14.227 BLBplus -152.81, 169.25 61.22, 47.15 -103.13, 164.19 45.91, 94.17 -79.63, 83.31 out-out out 15.632 Saltbr-out 15.916 HRD-in -74.73, -48.72 73.54, -6.07 out-out-out SNCooo out-out ActLoopNT-out 9.507 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -142.21, 151.98 APE9-dihe-na -130.61, 176.34 APE8-dihe-out -105.52, -25.24 APE8-rot-out 37.89 APE67-dihe-out -147.93, 136.16 -136.73, 176.12 APE12-dist-out 17.277 APE11-dist-out 17.584 APE10-dist-out 22.152 APE9-dist-out 13.001 S218A,S222A None None XRAY 3.5 0.208 0.254 H 395 318 33 0 0 0 [[68, 361]] 1.0 9o0v Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4U7ZA Q02750 62 382 393.0 3EW:60502,ANP:60503 Type3,ATPlike Inactive DFGin 6.216 13.669 BLBplus -143.34, -175.79 52.44, 38.8 -93.27, 161.31 44.21, 87.69 -81.82, 73.69 out-out out 15.334 Saltbr-out 16.14 HRD-in -66.47, -61.07 88.23, -17.21 out-out-out SNCooo out-out ActLoopNT-out 9.199 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_onoo APE10-dihe-na 999.0, -56.79 APE9-dihe-na 112.87, -133.38 APE8-dihe-out -132.3, 18.52 APE8-rot-out 53.52 APE67-dihe-out -108.34, 133.35 -145.71, 114.06 APE12-dist-out 17.933 APE11-dist-none 999.0 APE10-dist-out 19.601 APE9-dist-out 13.953 None None None XRAY 2.805 0.163 0.214 A 341 290 31 0 0 1 [[68, 361]] 1.0 4u7z Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4U81A Q02750 62 382 393.0 3EY:60502,ANP:60503 Type3,ATPlike Inactive DFGin 6.368 13.575 BLBplus -142.15, -179.17 57.69, 35.98 -93.9, 164.88 44.15, 86.95 -87.34, 72.9 out-out out 15.275 Saltbr-out 15.416 HRD-in -63.27, -55.06 80.23, -11.72 out-out-out SNCooo out-out ActLoopNT-out 9.324 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -28.47 APE9-dihe-na 110.81, -177.13 APE8-dihe-out -114.66, 19.88 APE8-rot-out 189.5 APE67-dihe-out -109.38, 142.31 -159.49, 131.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.684 APE9-dist-out 12.969 None None None XRAY 2.701 0.169 0.218 A 341 288 33 0 0 3 [[68, 361]] 1.0 4u81 Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9ECUB Q02750 43 383 393.0 A1BIS:401,ANP:402 Type3,ATPlike Inactive DFGin 5.939 13.778 BLBplus -142.06, 162.17 53.85, 47.21 -95.43, 152.31 51.94, 84.92 -79.97, 96.68 out-out out 15.512 Saltbr-out 16.13 HRD-in -66.75, -57.05 86.44, -9.92 out-out-out SNCooo out-out ActLoopNT-out 9.377 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -121.25, 157.88 APE9-dihe-na -135.0, 168.26 APE8-dihe-out -68.75, -42.35 APE8-rot-in 291.8 APE67-dihe-out -146.65, 140.6 -150.67, 174.43 APE12-dist-out 21.121 APE11-dist-out 17.894 APE10-dist-out 23.135 APE9-dist-out 13.656 None None None XRAY 3.46 0.202 0.237 B 393 309 32 0 0 0 [[68, 361]] 1.0 9ecu Homo sapiens STE_MAP2K1_HUMAN STE 2.4e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9AXYB Q02750 40 383 393.0 A1AHE:401,ANP:402 Type3,ATPlike Inactive DFGin 5.938 14.134 BLBplus -149.11, 165.49 51.9, 40.29 -92.3, 159.5 54.58, 76.32 -75.9, 70.87 out-out out 15.399 Saltbr-out 14.988 HRD-in -57.0, -47.47 79.88, -10.87 out-out-out SNCooo out-out ActLoopNT-out 9.337 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -115.09, 128.49 APE9-dihe-na -79.18, 173.05 APE8-dihe-out -111.11, -19.81 APE8-rot-out 47.95 APE67-dihe-out -148.5, 141.81 -130.51, 175.5 APE12-dist-out 18.176 APE11-dist-out 19.731 APE10-dist-out 22.785 APE9-dist-out 13.229 S218A,S222A None None XRAY 3.6 0.19 0.237 B 394 312 32 0 0 0 [[68, 361]] 1.0 9axy Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0VD Q02750 31 380 393.0 CHU:401,ANP:402 Type3,ATPlike Inactive DFGin 6.373 14.325 BLBplus -154.54, 169.16 62.18, 48.49 -103.44, 163.24 44.6, 81.5 -80.27, 83.26 out-out out 16.084 Saltbr-out 14.605 HRD-in -72.92, -47.49 72.01, -5.54 out-out-out SNCooo out-out ActLoopNT-out 9.498 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -145.24, 151.58 APE9-dihe-na -129.14, 150.7 APE8-dihe-out -101.27, -25.48 APE8-rot-in 295.39 APE67-dihe-out -149.5, 133.8 -134.87, 174.51 APE12-dist-out 17.681 APE11-dist-out 17.587 APE10-dist-out 22.613 APE9-dist-out 12.734 S218A,S222A None None XRAY 3.5 0.208 0.254 D 395 315 35 0 0 0 [[68, 361]] 1.0 9o0v Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 9O0VF Q02750 30 380 393.0 CHU:401,ANP:402 Type3,ATPlike Inactive DFGin 6.348 14.297 BLBplus -150.02, 162.92 66.4, 48.22 -102.89, 163.79 46.62, 89.05 -79.32, 84.9 out-out out 15.51 Saltbr-out 15.882 HRD-in -75.24, -46.98 72.8, -6.4 out-out-out SNCooo out-out ActLoopNT-out 9.801 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -127.4, 126.99 APE9-dihe-na -155.92, 117.08 APE8-dihe-out -98.23, -9.95 APE8-rot-in 320.72 APE67-dihe-out -148.49, 134.6 -133.67, 172.28 APE12-dist-out 18.674 APE11-dist-out 16.74 APE10-dist-out 21.344 APE9-dist-out 12.703 S218A,S222A None None XRAY 3.5 0.208 0.254 F 395 322 29 0 0 0 [[68, 361]] 1.0 9o0v Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0TB Q02750 42 383 393.0 3EW:401,ANP:402 Type3,ATPlike Inactive DFGin 6.075 13.71 BLBplus -159.9, -178.5 64.02, 41.63 -104.3, 143.17 46.34, 100.82 -64.54, 70.24 out-out out 15.478 Saltbr-out 16.332 HRD-in -53.73, -55.69 69.68, 5.22 out-out-out SNCooo out-out ActLoopNT-out 8.871 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -40.91, 141.26 APE9-dihe-na -101.18, -177.28 APE8-dihe-out -68.44, -50.32 APE8-rot-in 321.79 APE67-dihe-out -148.38, 132.66 -145.97, 175.15 APE12-dist-out 17.166 APE11-dist-out 22.648 APE10-dist-out 23.709 APE9-dist-out 13.864 S218A,S222A None None XRAY 3.19 0.199 0.254 B 397 310 32 0 0 0 [[68, 361]] 1.0 7m0t Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7M0UB Q02750 43 385 393.0 QO7:501,ANP:502 Type3,ATPlike Inactive DFGin 6.178 13.84 BLBplus -152.87, -177.82 54.02, 43.66 -96.33, 148.45 42.9, 86.91 -71.94, 82.66 out-out out 15.493 Saltbr-out 15.664 HRD-in -60.41, -57.85 71.46, -3.21 out-out-out SNCooo out-out ActLoopNT-out 9.048 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -60.78, 138.09 APE9-dihe-na -86.76, -175.69 APE8-dihe-out -100.26, -15.57 APE8-rot-out 49.06 APE67-dihe-out -118.78, 147.11 -163.65, 150.46 APE12-dist-out 17.201 APE11-dist-out 22.359 APE10-dist-out 23.566 APE9-dist-out 13.638 S218A,S222A None None XRAY 3.09 0.193 0.23 B 397 311 32 0 0 0 [[68, 361]] 1.0 7m0u Homo sapiens STE_MAP2K1_HUMAN STE 1.1e-96 329.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 5YT3B Q02750 40 382 393.0 ANP:401 ATPlike Inactive DFGin 5.896 14.534 None -102.15, -169.78 -40.15, 149.52 -75.91, 143.56 303.08, 84.8 -64.88, 94.03 out-out out 16.359 Saltbr-out 14.866 HRD-out -104.42, 23.77 -144.46, 111.13 out-out-out SNCooo out-out ActLoopNT-out 8.021 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -80.58, -32.09 APE9-dihe-na -86.11, -15.83 APE8-dihe-out 58.15, 64.44 APE8-rot-in 310.76 APE67-dihe-out -122.56, 143.11 -138.66, 139.98 APE12-dist-out 19.055 APE11-dist-out 14.055 APE10-dist-out 18.84 APE9-dist-out 25.91 S218D,S222D,T292A,S298A None None XRAY 2.9 0.213 0.289 B 350 311 32 0 0 0 [[68, 361]] 1.0 5yt3 Homo sapiens STE_MAP2K1_HUMAN STE 4.7e-97 330.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 5YT3D Q02750 39 382 393.0 ANP:401 ATPlike Inactive DFGin 5.75 14.718 None -77.53, 172.31 -71.81, 159.92 -66.82, 141.72 314.31, 87.77 -59.96, 135.61 out-out out 16.872 Saltbr-out 15.006 HRD-out -106.97, -11.01 -97.02, 107.72 out-out-out SNCooo out-out ActLoopNT-out 8.244 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -63.82, -51.0 APE9-dihe-na -70.37, -13.35 APE8-dihe-out 47.35, 74.88 APE8-rot-out 143.99 APE67-dihe-out -134.73, 126.26 -143.64, 140.67 APE12-dist-out 19.339 APE11-dist-out 14.382 APE10-dist-out 19.155 APE9-dist-out 26.168 S218D,S222D,T292A,S298A None None XRAY 2.9 0.213 0.289 D 350 309 35 0 0 0 [[68, 361]] 1.0 5yt3 Homo sapiens STE_MAP2K1_HUMAN STE 4.7e-97 330.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 5YT3A Q02750 39 382 393.0 ANP:401 ATPlike Inactive DFGinter 6.357 10.383 None -128.68, 173.26 63.68, 38.66 -52.93, -21.76 28.6, 36.22 -61.84, 114.84 out-out out 16.315 Saltbr-out 14.589 HRD-in -77.7, -42.23 58.41, 13.61 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 70.97 APE8-rot-none 999.0 APE67-dihe-out -132.4, 139.8 -149.07, 91.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S218D,S222D,T292A,S298A None None XRAY 2.9 0.213 0.289 A 350 297 47 0 0 14 [[68, 361]] 1.0 5yt3 Homo sapiens STE_MAP2K1_HUMAN STE 4.7e-97 330.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 7F2XA Q02750 45 382 393.0 ANP:60501 ATPlike Inactive None 14.578 16.496 None -71.03, 160.3 -74.32, 105.83 -69.14, -7.13 285.96, 1.01 -79.69, -8.9 out-out out 16.361 Saltbr-out 16.873 HRD-out -123.25, -2.01 -136.26, 151.99 out-out-out SNCooo out-out ActLoopNT-out 10.375 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -84.56, -47.24 APE9-dihe-na 151.04, 109.57 APE8-dihe-in -68.48, 129.23 APE8-rot-in 304.12 APE67-dihe-out -103.66, 129.16 -127.47, 104.31 APE12-dist-out 14.456 APE11-dist-out 17.673 APE10-dist-out 20.308 APE9-dist-out 25.523 None None None XRAY 2.007 0.216 0.232 A 321 300 0 0 0 0 [[68, 361]] 1.0 7f2x Homo sapiens STE_MAP2K1_HUMAN STE 1.4e-97 332.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K4 MP2K4_HUMAN 3ALNA P45985 83 389 399.0 ANP:1 ATPlike Inactive DFGin 6.517 13.393 BLBplus -161.78, 169.91 72.82, 15.08 -92.63, 122.04 60.81, 71.89 121.07, -111.8 na-na na 15.525 Saltbr-na 999.0 HRD-in -50.15, -58.45 86.79, 0.09 na-out-none SNCaon out-none ActLoopNT-out 11.094 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.289 0.378 A 327 270 37 0 0 20 [[102, 367]] 1.0 3aln Homo sapiens STE_MAP2K4_HUMAN STE 6.8e-86 293.8 4 257 254 246 247 248 250 252 131 148 152 226 228 227 229 289 273 268 267 266 265 264 263 262 179 Dual specificity mitogen-activated protein kinase kinase 4
STE MAP2K4 MP2K4_HUMAN 3ALNB P45985 84 390 399.0 ANP:1 ATPlike Inactive DFGin 7.062 13.613 BLBplus -140.58, 160.03 87.63, 22.27 -95.55, 159.55 58.77, 88.3 94.56, -147.05 na-na na 15.267 Saltbr-na 14.949 HRD-in -87.89, -53.1 65.57, 1.61 na-out-none SNCaon out-none ActLoopNT-out 8.255 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.289 0.378 B 327 263 44 0 0 19 [[102, 367]] 1.0 3aln Homo sapiens STE_MAP2K4_HUMAN STE 6.8e-86 293.8 4 257 254 246 247 248 250 252 131 148 152 226 228 227 229 289 273 268 267 266 265 264 263 262 179 Dual specificity mitogen-activated protein kinase kinase 4
STE MAP2K4 MP2K4_HUMAN 3ALOA P45985 95 389 399.0 ANP:406 ATPlike Inactive DFGin 6.887 13.729 BLBplus -112.59, -177.7 66.85, 21.6 -92.73, 167.28 50.76, 92.54 73.18, -126.21 na-na na 15.89 Saltbr-na 16.476 HRD-in -52.75, -64.74 82.96, 2.2 na-out-out SNCaoo out-out ActLoopNT-out 8.257 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na -57.34, 98.51 APE9-dihe-na 135.89, -16.86 APE8-dihe-out -126.39, -33.94 APE8-rot-na 70.02 APE67-dihe-out -48.7, -17.03 -94.49, 137.34 APE12-dist-out 18.454 APE11-dist-out 19.517 APE10-dist-out 20.495 APE9-dist-out 23.026 None None None XRAY 2.6 0.209 0.271 A 327 289 6 0 0 0 [[102, 367]] 1.0 3alo Homo sapiens STE_MAP2K4_HUMAN STE 6.8e-86 293.8 4 257 254 246 247 248 250 252 131 148 152 226 228 227 229 289 273 268 267 266 265 264 263 262 179 Dual specificity mitogen-activated protein kinase kinase 4
STE MAP2K4 MP2K4_HUMAN 3ALNC P45985 100 390 399.0 ANP:1 ATPlike Inactive None 999.0 11.66 None -139.2, 85.12 54.71, 167.37 -67.61, 999.0 74.38, 108.84 999.0, 999.0 na-na na 999.0 Saltbr-na 999.0 HRD-none 999.0, 999.0 999.0, 999.0 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.289 0.378 C 327 183 108 0 0 25 [[102, 367]] 1.0 3aln Homo sapiens STE_MAP2K4_HUMAN STE 6.8e-86 293.8 4 257 254 246 247 248 250 252 131 148 152 226 228 227 229 289 273 268 267 266 265 264 263 262 179 Dual specificity mitogen-activated protein kinase kinase 4
STE MAP4K1 M4K1_HUMAN 6CQDA Q92918 2 293 833.0 ANP:60301 ATPlike Inactive DFGin 6.032 13.886 BLAminus -140.97, 178.85 65.6, 83.06 -106.07, 25.72 286.0, 93.85 -58.74, -52.87 in-in in 8.588 Saltbr-in 2.603 HRD-in -75.86, -49.25 70.86, -6.64 in-out-out SNCioo out-out ActLoopNT-out 5.612 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -107.43, -47.34 APE9-dihe-na -128.13, -155.64 APE8-dihe-in -106.29, 135.18 APE8-rot-out 173.28 APE67-dihe-in -57.05, -28.95 -70.03, -34.9 APE12-dist-out 19.71 APE11-dist-out 23.507 APE10-dist-out 22.083 APE9-dist-out 27.312 None None None XRAY 2.12 0.206 0.25 A 297 288 4 0 0 0 [[17, 274]] 1.0 6cqd Homo sapiens STE_MAP4K1_HUMAN STE 4.2e-92 314.0 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 6CQDB Q92918 4 293 833.0 ANP:60302 ATPlike Inactive DFGin 6.101 14.229 BLAminus -144.26, -175.8 58.68, 77.54 -93.97, 33.74 292.79, 90.96 -66.13, -50.88 in-in in 9.463 Saltbr-in 3.209 HRD-in -76.3, -46.87 66.26, 5.48 in-out-out SNCioo out-out ActLoopNT-out 6.073 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -81.26, 126.5 APE9-dihe-na -81.79, -144.73 APE8-dihe-in -66.65, 145.16 APE8-rot-out 188.81 APE67-dihe-in -66.31, -22.65 -105.18, -2.62 APE12-dist-out 20.763 APE11-dist-out 21.959 APE10-dist-out 21.41 APE9-dist-out 27.357 None None None XRAY 2.12 0.206 0.25 B 297 290 0 0 0 0 [[17, 274]] 1.0 6cqd Homo sapiens STE_MAP4K1_HUMAN STE 4.2e-92 314.0 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K4 M4K4_HUMAN 4U40A O95819 17 311 1239.0 ANP:401 ATPlike Inactive DFGin 3.837 14.39 BLBplus -136.79, 156.81 66.63, 45.06 -75.84, 145.72 56.03, 93.39 -61.09, 117.37 out-out out 11.64 Saltbr-out 10.489 HRD-in -68.35, -49.63 65.89, 2.04 out-out-out SNCooo out-out ActLoopNT-out 9.628 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -76.11, -36.45 APE9-dihe-na 89.46, 175.41 APE8-dihe-in -63.67, 133.35 APE8-rot-out 188.73 APE67-dihe-in -61.71, -22.93 -96.09, -7.57 APE12-dist-out 14.877 APE11-dist-out 14.965 APE10-dist-out 15.978 APE9-dist-out 9.477 None None None XRAY 2.3 0.201 0.262 A 332 295 0 0 0 0 [[25, 289]] 1.0 4u40 Homo sapiens STE_MAP4K4_HUMAN STE 1.7e-102 348.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
STE OXSR1 OXSR1_HUMAN 3DAKA O95747 6 295 527.0 ANP:1 ATPlike Inactive DFGin 5.129 16.177 BLBtrans -100.04, 163.42 76.18, 16.7 -60.44, 136.33 171.32, 70.03 96.86, -127.31 out-out out 12.585 Saltbr-out 12.035 HRD-in -76.04, -45.57 81.12, -26.2 out-out-out SNCooo out-out ActLoopNT-out 8.169 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -91.06 APE9-dihe-na 161.92, -137.1 APE8-dihe-in -95.05, 112.91 APE8-rot-in 254.7 APE67-dihe-in -56.68, -24.99 -85.34, 38.29 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 29.384 APE9-dist-out 30.051 None None None XRAY 2.25 0.199 0.267 A 290 279 11 0 0 11 [[17, 291]] 1.0 3dak Homo sapiens STE_OXSR1_HUMAN STE 6e-94 320.1 1 257 257 163 164 165 167 169 46 63 67 143 145 144 146 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 3DAKB O95747 6 295 527.0 ANP:1 ATPlike Inactive DFGin 5.332 16.237 BLBtrans -104.22, 159.58 79.05, 11.08 -51.8, 136.57 175.99, 64.12 96.31, -131.54 out-out out 12.456 Saltbr-out 12.083 HRD-in -78.09, -47.02 83.9, -24.13 out-out-none SNCoon out-none ActLoopNT-out 8.147 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 130.99 APE8-rot-in 294.38 APE67-dihe-in -53.25, -31.09 -85.79, 34.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.25 0.199 0.267 B 290 278 12 0 0 12 [[17, 291]] 1.0 3dak Homo sapiens STE_OXSR1_HUMAN STE 6e-94 320.1 1 257 257 163 164 165 167 169 46 63 67 143 145 144 146 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 3DAKC O95747 7 295 527.0 ANP:1 ATPlike Inactive DFGin 5.2 16.258 BLBtrans -99.19, 165.37 77.39, 13.36 -54.55, 139.89 174.92, 66.03 90.2, -129.87 out-out out 12.795 Saltbr-out 12.192 HRD-in -79.55, -55.89 92.02, -15.23 out-out-out SNCooo out-out ActLoopNT-out 8.072 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -81.49, 148.28 APE9-dihe-na 113.95, 160.67 APE8-dihe-in -84.39, 122.06 APE8-rot-out 195.33 APE67-dihe-in -62.35, -26.54 -78.99, 38.41 APE12-dist-out 26.325 APE11-dist-out 28.851 APE10-dist-out 33.354 APE9-dist-out 31.678 None None None XRAY 2.25 0.199 0.267 C 290 281 8 0 0 8 [[17, 291]] 1.0 3dak Homo sapiens STE_OXSR1_HUMAN STE 6e-94 320.1 1 257 257 163 164 165 167 169 46 63 67 143 145 144 146 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 3DAKD O95747 7 295 527.0 ANP:1 ATPlike Inactive DFGin 5.521 16.6 BLBtrans -91.03, 168.13 66.29, 18.87 -59.74, 133.08 178.71, 62.0 94.13, -120.8 out-out out 12.738 Saltbr-out 12.031 HRD-in -82.87, -52.16 83.38, -16.35 out-out-out SNCooo out-out ActLoopNT-out 8.249 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -78.42, 169.6 APE9-dihe-na 94.12, 158.49 APE8-dihe-in -86.45, 138.34 APE8-rot-out 182.04 APE67-dihe-in -59.03, -28.5 -85.94, 35.36 APE12-dist-none 999.0 APE11-dist-out 29.808 APE10-dist-out 33.489 APE9-dist-out 31.915 None None None XRAY 2.25 0.199 0.267 D 290 284 5 0 0 5 [[17, 291]] 1.0 3dak Homo sapiens STE_OXSR1_HUMAN STE 6e-94 320.1 1 257 257 163 164 165 167 169 46 63 67 143 145 144 146 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 2VWIB O95747 9 292 527.0 ANP:1295 ATPlike Inactive DFGin 5.287 16.427 BLBtrans -100.18, 160.58 80.18, 12.17 -59.65, 137.68 171.88, 72.09 96.85, -127.69 out-out out 12.997 Saltbr-out 12.206 HRD-in -71.44, -47.93 86.11, -20.42 out-out-none SNCoon out-none ActLoopNT-out 7.967 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 75.95 APE8-rot-in 320.74 APE67-dihe-in -62.37, -32.44 -100.52, 20.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.15 0.253 0.287 B 303 264 20 0 0 12 [[17, 291]] 1.0 2vwi Homo sapiens STE_OXSR1_HUMAN STE 7.1e-94 319.8 1 257 257 163 164 165 167 169 46 63 67 143 145 144 146 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 2VWIC O95747 9 292 527.0 ANP:1294 ATPlike Inactive DFGin 5.301 16.228 BLBtrans -96.83, 164.86 72.67, 17.81 -61.87, 137.0 171.22, 69.43 96.65, -124.96 out-out out 12.818 Saltbr-out 12.435 HRD-in -77.27, -48.25 84.09, -19.76 out-out-out SNCooo out-out ActLoopNT-out 7.978 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 143.21 APE9-dihe-na 99.05, -143.58 APE8-dihe-in -115.19, 90.11 APE8-rot-out 49.11 APE67-dihe-in -67.35, -20.96 -80.96, 15.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 29.087 APE9-dist-out 29.408 None None None XRAY 2.15 0.253 0.287 C 303 271 13 0 0 5 [[17, 291]] 1.0 2vwi Homo sapiens STE_OXSR1_HUMAN STE 7.1e-94 319.8 1 257 257 163 164 165 167 169 46 63 67 143 145 144 146 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 2VWID O95747 6 298 527.0 ANP:1300 ATPlike Inactive DFGin 5.179 16.223 BLBtrans -101.51, 161.03 73.3, 16.0 -58.73, 139.72 167.14, 71.27 94.08, -129.9 out-out out 12.663 Saltbr-out 12.411 HRD-in -67.92, -49.61 77.45, -14.4 out-out-out SNCooo out-out ActLoopNT-out 7.943 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -84.67, 122.36 APE9-dihe-na 118.58, -169.41 APE8-dihe-in -120.4, 114.0 APE8-rot-in 321.26 APE67-dihe-in -59.9, -22.77 -41.25, -46.54 APE12-dist-out 29.134 APE11-dist-out 28.073 APE10-dist-out 29.314 APE9-dist-out 29.161 None None None XRAY 2.15 0.253 0.287 D 303 284 9 0 0 9 [[17, 291]] 1.0 2vwi Homo sapiens STE_OXSR1_HUMAN STE 7.1e-94 319.8 1 257 257 163 164 165 167 169 46 63 67 143 145 144 146 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE OXSR1 OXSR1_HUMAN 2VWIA O95747 13 292 527.0 ANP:1294 ATPlike Inactive DFGin 8.898 15.601 None -61.18, 158.62 -55.34, 143.64 -131.37, -0.25 74.39, 103.15 -56.05, -46.66 none-none none 999.0 Saltbr-none 999.0 HRD-in -71.19, -49.86 82.28, -11.12 none-out-out SNCnoo out-out ActLoopNT-out 5.998 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -154.6 APE8-dihe-in -114.29, 105.56 APE8-rot-out 57.55 APE67-dihe-in -58.83, -26.11 -92.35, 9.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 28.136 None None None XRAY 2.15 0.253 0.287 A 303 237 43 0 0 15 [[17, 291]] 1.0 2vwi Homo sapiens STE_OXSR1_HUMAN STE 7.1e-94 319.8 1 257 257 163 164 165 167 169 46 63 67 143 145 144 146 209 196 191 190 189 188 187 186 185 93 Serine/threonine-protein kinase OSR1
STE PAK1 PAK1_HUMAN 3Q4ZA Q13153 251 545 545.0 ANP:60800 ATPlike Inactive DFGin 6.086 15.982 BLAminus -129.5, -163.35 61.16, 72.73 -92.37, 13.66 295.77, 79.36 -60.94, -29.11 out-none out 10.187 Saltbr-none 999.0 HRD-in -71.1, -48.5 65.7, -2.93 none-in-in SNCnii in-in ActLoopNT-in 2.767 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.35, 142.5 APE9-dihe-na 131.45, -160.89 APE8-dihe-in -120.18, 125.75 APE8-rot-in 304.74 APE67-dihe-in -64.8, -21.76 -41.32, -52.02 APE12-dist-in 9.957 APE11-dist-in 11.743 APE10-dist-in 6.028 APE9-dist-in 3.332 S259I,K299R,D389N,L516I None None XRAY 1.887 0.186 0.231 A 306 281 12 0 0 0 [[270, 521]] 1.0 3q4z Homo sapiens STE_PAK1_HUMAN STE 2e-93 318.4 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK4 PAK4_HUMAN 4FIFA O96013 296 589 591.0 ANP:1000 ATPlike Active DFGin 6.132 13.879 BLAminus -134.27, -172.64 55.78, 65.69 -91.22, 11.11 299.57, 98.92 -61.37, -20.58 in-in in 7.046 Saltbr-in 3.112 HRD-in -73.18, -47.2 74.11, -8.39 in-in-in SNCiii in-in ActLoopNT-in 2.852 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.08, 134.89 APE9-dihe-na 136.18, -173.61 APE8-dihe-in -102.98, 119.55 APE8-rot-in 312.46 APE67-dihe-in -69.75, -26.2 -30.93, -52.34 APE12-dist-in 9.318 APE11-dist-in 11.709 APE10-dist-in 5.875 APE9-dist-in 3.299 None SEP474 SEP474 XRAY 2.6 0.207 0.227 A 346 294 0 0 0 0 [[321, 572]] 1.0 4fif Homo sapiens STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIFB O96013 297 589 591.0 ANP:1000 ATPlike Active DFGin 5.899 13.85 BLAminus -129.09, -170.37 52.27, 68.51 -93.51, 10.45 301.97, 96.23 -63.09, -15.01 in-in in 7.007 Saltbr-in 3.167 HRD-in -65.39, -48.9 75.1, -7.5 in-in-in SNCiii in-in ActLoopNT-in 2.801 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.88, 134.77 APE9-dihe-na 136.42, -174.06 APE8-dihe-in -101.96, 121.94 APE8-rot-in 314.36 APE67-dihe-in -72.79, -21.56 -33.03, -50.98 APE12-dist-in 9.238 APE11-dist-in 11.712 APE10-dist-in 5.886 APE9-dist-in 3.335 None SEP474 SEP474 XRAY 2.6 0.207 0.227 B 346 293 0 0 0 0 [[321, 572]] 1.0 4fif Homo sapiens STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIGA O96013 298 590 591.0 ANP:1001 ATPlike Inactive DFGin 5.976 13.995 BLAminus -134.45, -166.25 59.06, 57.3 -88.34, 9.13 298.9, 106.14 -61.58, -20.66 in-in in 7.133 Saltbr-in 3.168 HRD-in -77.25, -46.66 72.07, -3.1 in-in-out SNCiio in-out ActLoopNT-in 2.86 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.47, 161.1 APE9-dihe-na 110.61, 163.55 APE8-dihe-in -79.54, 130.34 APE8-rot-out 29.96 APE67-dihe-in -76.38, -28.34 -35.31, -49.63 APE12-dist-in 9.418 APE11-dist-in 11.569 APE10-dist-in 5.635 APE9-dist-in 3.369 None SEP474 SEP474 XRAY 3.01 0.197 0.221 A 346 293 0 0 0 0 [[321, 572]] 1.0 4fig Homo sapiens STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4JDIA O96013 300 589 591.0 ANP:1000 ATPlike Active DFGin 6.291 14.47 BLAminus -134.26, 177.87 63.72, 71.58 -94.6, 13.78 289.77, 79.71 -54.15, -28.77 in-in in 6.959 Saltbr-in 2.737 HRD-in -72.82, -49.09 73.48, 2.76 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.62, 145.0 APE9-dihe-na 130.41, -160.49 APE8-dihe-in -120.53, 123.45 APE8-rot-in 305.94 APE67-dihe-in -63.49, -22.51 -36.89, -56.07 APE12-dist-in 8.769 APE11-dist-in 11.535 APE10-dist-in 5.874 APE9-dist-in 3.327 None SEP474 SEP474 XRAY 1.85 0.194 0.233 A 346 290 0 0 0 0 [[321, 572]] 1.0 4jdi Homo sapiens STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 5UPKB O96013 300 588 591.0 ANP:60600 ATPlike Active DFGin 6.272 14.139 BLAminus -132.3, -169.35 61.71, 61.5 -87.86, 7.28 293.59, 93.96 -55.36, -28.3 in-in in 7.077 Saltbr-in 3.329 HRD-in -65.35, -49.16 70.36, 11.54 in-in-in SNCiii in-in ActLoopNT-in 2.997 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.55, 149.52 APE9-dihe-na 120.09, -163.11 APE8-dihe-in -119.51, 121.87 APE8-rot-in 313.98 APE67-dihe-in -69.89, -18.98 -32.47, -57.41 APE12-dist-in 8.623 APE11-dist-in 11.267 APE10-dist-in 5.616 APE9-dist-in 3.426 None SEP474 SEP474 XRAY 2.4 0.22 0.264 B 346 289 0 0 0 0 [[321, 572]] 1.0 5upk Homo sapiens STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIEA O96013 49 590 591.0 ANP:1001 ATPlike Inactive DFGin 6.278 14.03 BLAminus -142.71, -177.86 63.75, 67.7 -92.97, 13.53 295.29, 98.36 -64.15, -7.0 in-out in 6.991 Saltbr-out 3.974 HRD-in -74.78, -36.69 67.65, -13.13 out-in-out SNCoio in-out ActLoopNT-in 2.856 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -135.98, 139.97 APE9-dihe-na 123.6, -177.34 APE8-dihe-in -84.44, 139.76 APE8-rot-out 19.51 APE67-dihe-in -74.38, -37.99 -51.24, -48.18 APE12-dist-in 9.515 APE11-dist-in 11.685 APE10-dist-in 5.909 APE9-dist-in 3.508 None SEP474 SEP474 XRAY 3.11 0.257 0.276 A 423 301 0 0 0 0 [[321, 572]] 1.0 4fie Homo sapiens STE_PAK4_HUMAN STE 5.6e-88 300.6 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIEB O96013 49 590 591.0 ANP:1001 ATPlike Inactive DFGin 6.278 14.031 BLAminus -142.24, -177.62 63.59, 67.55 -92.7, 13.49 295.33, 98.22 -64.04, -7.21 in-out in 6.989 Saltbr-out 3.957 HRD-in -74.95, -36.21 66.97, -12.74 out-in-out SNCoio in-out ActLoopNT-in 2.857 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.0, 139.86 APE9-dihe-na 123.6, -177.41 APE8-dihe-in -84.57, 139.76 APE8-rot-out 19.62 APE67-dihe-in -74.42, -37.89 -51.19, -48.15 APE12-dist-in 9.515 APE11-dist-in 11.689 APE10-dist-in 5.912 APE9-dist-in 3.51 None SEP474 SEP474 XRAY 3.11 0.257 0.276 B 423 301 0 0 0 0 [[321, 572]] 1.0 4fie Homo sapiens STE_PAK4_HUMAN STE 5.6e-88 300.6 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 7S46A O96013 300 589 591.0 ANP:600 ATPlike Active DFGin 9.021 14.349 BLAminus -133.61, -177.07 54.75, 76.68 -92.18, 14.46 286.49, 80.35 -59.04, -19.55 in-in in 7.534 Saltbr-in 2.867 HRD-in -69.43, -50.5 76.76, 2.96 in-in-in SNCiii in-in ActLoopNT-in 2.922 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.73, 132.58 APE9-dihe-na 145.82, -167.86 APE8-dihe-in -110.13, 128.57 APE8-rot-in 305.26 APE67-dihe-in -70.79, -21.11 -38.41, -55.32 APE12-dist-in 9.02 APE11-dist-in 11.537 APE10-dist-in 5.793 APE9-dist-in 3.286 D440N,S474E None None XRAY 2.1 0.182 0.22 A 346 290 0 0 0 0 [[321, 572]] 1.0 7s46 Homo sapiens STE_PAK4_HUMAN STE 5.5e-87 297.4 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 7S47A O96013 300 589 591.0 ANP:600 ATPlike Active DFGin 9.217 14.646 BLAminus -126.8, -179.34 54.51, 73.91 -89.97, 15.41 285.81, 78.05 -59.21, -18.99 in-in in 7.79 Saltbr-in 2.931 HRD-in -66.64, -48.47 70.7, 6.89 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.53, 138.41 APE9-dihe-na 140.72, -164.27 APE8-dihe-in -114.61, 124.35 APE8-rot-in 304.9 APE67-dihe-in -66.22, -20.32 -36.39, -56.83 APE12-dist-in 9.039 APE11-dist-in 11.45 APE10-dist-in 5.747 APE9-dist-in 3.401 D440N,S474E None None XRAY 2.0 0.196 0.237 A 383 290 0 0 0 0 [[321, 572]] 1.0 7s47 Homo sapiens STE_PAK4_HUMAN STE 7.5e-87 297.0 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE PAK4 PAK4_HUMAN 4FIGB O96013 298 590 591.0 ANP:602 ATPlike Inactive DFGin 5.979 13.845 None -136.1, -40.27 -82.41, 70.29 -85.54, 12.48 305.29, 106.7 -66.77, -24.27 in-in in 7.007 Saltbr-in 3.047 HRD-in -63.37, -48.9 73.21, -4.05 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.8, 141.64 APE9-dihe-na 130.69, -165.45 APE8-dihe-in -110.43, 122.9 APE8-rot-in 324.7 APE67-dihe-in -77.33, -31.89 -29.23, -51.11 APE12-dist-in 9.706 APE11-dist-in 11.743 APE10-dist-in 5.92 APE9-dist-in 3.386 None SEP474 SEP474 XRAY 3.01 0.197 0.221 B 346 293 0 0 0 0 [[321, 572]] 1.0 4fig Homo sapiens STE_PAK4_HUMAN STE 3.1e-88 301.5 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE STK24 STK24_HUMAN 4QMLA Q9Y6E0 30 310 443.0 ANP:60403 ATPlike Active DFGin 6.598 15.178 BLAminus -130.38, 172.22 70.9, 79.24 -104.53, 20.01 285.96, 83.16 -61.35, -25.21 in-in in 9.065 Saltbr-in 2.927 HRD-in -70.82, -51.82 74.23, -2.97 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.04, 155.96 APE9-dihe-na 125.92, -168.67 APE8-dihe-in -115.63, 119.31 APE8-rot-in 310.36 APE67-dihe-in -60.1, -29.49 -47.33, -42.77 APE12-dist-in 8.276 APE11-dist-in 11.051 APE10-dist-in 5.558 APE9-dist-in 3.386 None TPO190 TPO190 XRAY 1.882 0.19 0.23 A 310 281 0 0 0 0 [[36, 286]] 1.0 4qml Homo sapiens STE_STK24_HUMAN STE 3.9e-100 340.4 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK3 STK3_HUMAN 6AO5A Q13188 28 488 491.0 ANP:501 ATPlike Inactive DFGin 5.762 13.255 BLAplus -144.87, 157.4 64.61, 76.09 -109.93, -46.63 13.82, 108.09 -89.31, 27.29 out-out out 12.908 Saltbr-out 12.116 HRD-in -60.56, -48.36 76.32, -35.33 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nooo APE10-dihe-na -164.34, 157.95 APE9-dihe-na -118.75, -167.2 APE8-dihe-in -63.94, 121.38 APE8-rot-out 166.95 APE67-dihe-out -86.4, -39.81 -115.82, 59.17 APE12-dist-none 999.0 APE11-dist-out 17.895 APE10-dist-out 16.152 APE9-dist-out 11.062 D146N None None XRAY 2.955 0.236 0.256 A 362 321 27 0 0 12 [[27, 278]] 1.0 6ao5 Homo sapiens STE_STK3_HUMAN STE 3.6e-100 340.7 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 4LGDA Q13188 16 488 491.0 ANP:501 ATPlike Inactive DFGin 6.018 17.02 BLBminus -145.52, -179.3 43.95, 67.54 -70.27, 152.23 281.57, 44.13 -80.59, 163.91 out-out out 10.889 Saltbr-out 5.794 HRD-in -73.7, -41.12 68.58, 5.1 out-out-out SNCooo out-out ActLoopNT-out 8.717 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -60.16, -34.45 APE9-dihe-na -67.84, -18.95 APE8-dihe-in -138.32, 78.16 APE8-rot-in 307.08 APE67-dihe-in -67.01, -21.51 -99.04, 14.35 APE12-dist-in 12.457 APE11-dist-in 10.195 APE10-dist-out 15.269 APE9-dist-out 12.752 D146N None None XRAY 3.05 0.202 0.244 A 378 350 0 0 0 0 [[27, 278]] 1.0 4lgd Homo sapiens STE_STK3_HUMAN STE 4.1e-100 340.6 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 4LGDB Q13188 10 488 491.0 ANP:501 ATPlike Inactive DFGin 6.16 16.692 BLBminus -138.64, 169.86 44.76, 62.12 -62.36, 151.89 285.61, 26.54 -88.9, 160.74 out-out out 10.736 Saltbr-out 6.022 HRD-in -77.36, -41.29 64.17, 12.1 out-out-out SNCooo out-out ActLoopNT-out 9.006 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -74.54, -22.15 APE9-dihe-na -64.82, -19.37 APE8-dihe-in -144.49, 84.11 APE8-rot-in 305.11 APE67-dihe-in -63.85, -34.86 -100.76, 15.67 APE12-dist-in 12.595 APE11-dist-in 10.253 APE10-dist-out 15.046 APE9-dist-out 12.722 D146N None None XRAY 3.05 0.202 0.244 B 378 350 0 0 0 0 [[27, 278]] 1.0 4lgd Homo sapiens STE_STK3_HUMAN STE 4.1e-100 340.6 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 4LGDC Q13188 12 490 491.0 ANP:501 ATPlike Inactive DFGin 6.359 17.118 BLBminus -149.78, 166.61 51.14, 65.46 -62.65, 153.33 284.02, 26.74 -77.49, 169.34 out-out out 10.55 Saltbr-out 5.611 HRD-in -72.97, -46.37 72.83, -1.88 out-out-out SNCooo out-out ActLoopNT-out 9.037 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -57.36, -33.07 APE9-dihe-na -66.61, -18.79 APE8-dihe-in -138.0, 80.15 APE8-rot-in 301.29 APE67-dihe-in -70.28, -28.9 -100.7, 15.38 APE12-dist-in 12.447 APE11-dist-in 10.03 APE10-dist-out 15.197 APE9-dist-out 12.67 D146N None None XRAY 3.05 0.202 0.244 C 378 349 7 0 0 0 [[27, 278]] 1.0 4lgd Homo sapiens STE_STK3_HUMAN STE 4.1e-100 340.6 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STE STK3 STK3_HUMAN 4LGDD Q13188 11 489 491.0 ANP:501 ATPlike Inactive DFGin 6.268 16.891 BLBminus -143.39, 170.34 44.57, 62.98 -62.31, 161.36 279.47, 45.38 -101.43, 151.87 out-out out 10.794 Saltbr-out 6.287 HRD-in -67.38, -41.94 64.94, 10.19 out-out-out SNCooo out-out ActLoopNT-out 8.791 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -65.98, -30.48 APE9-dihe-na -65.09, -18.33 APE8-dihe-in -145.24, 79.51 APE8-rot-in 304.52 APE67-dihe-in -64.33, -26.69 -98.63, 11.94 APE12-dist-in 12.433 APE11-dist-in 10.306 APE10-dist-out 15.377 APE9-dist-out 12.751 D146N None None XRAY 3.05 0.202 0.244 D 378 338 0 0 0 0 [[27, 278]] 1.0 4lgd Homo sapiens STE_STK3_HUMAN STE 4.1e-100 340.6 2 257 256 163 164 165 167 169 56 70 74 143 145 144 146 203 191 186 185 184 183 182 181 180 100 Serine/threonine-protein kinase 3
STE STRADA STRAA_HUMAN 2WTKB Q7RTN6 61 431 431.0 ANP:432 ATPlike Pseudo DFGin 5.116 13.443 BLAminus -117.01, -150.73 71.3, 24.64 -54.34, -28.38 297.58, 14.45 -57.14, -26.88 out-none out 10.016 Saltbr-none 999.0 HRD-in -75.87, -56.89 78.73, -4.32 none-in-out SNCnio in-out ActLoopNT-in 2.921 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_iooo APE10-dihe-na -50.59, -53.43 APE9-dihe-na -67.53, -3.25 APE8-dihe-out -106.64, -20.66 APE8-rot-na 143.84 APE67-dihe-in -56.31, -21.98 -28.24, -53.75 APE12-dist-in 8.271 APE11-dist-out 7.456 APE10-dist-out 12.843 APE9-dist-out 9.371 None None None XRAY 2.65 0.24 0.291 B 373 311 52 0 0 0 [[69, 379]] 1.0 2wtk Homo sapiens STE_STRADA_HUMAN STE 4e-87 298.0 1 257 257 212 213 214 216 218 100 118 122 192 194 193 195 261 247 242 241 240 239 238 237 236 148 STE20-related kinase adapter protein alpha
STE STRADA STRAA_HUMAN 2WTKE Q7RTN6 60 431 431.0 ANP:432 ATPlike Pseudo DFGin 5.076 13.591 BLAminus -114.47, -147.76 66.21, 35.38 -66.23, -19.97 288.54, 169.08 -50.33, -33.69 in-none in 9.934 Saltbr-none 999.0 HRD-in -67.35, -61.05 78.73, -1.12 none-in-out SNCnio in-out ActLoopNT-in 2.861 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_iooo APE10-dihe-na -48.76, -50.43 APE9-dihe-na -62.69, -41.12 APE8-dihe-out -68.21, -28.45 APE8-rot-na 167.78 APE67-dihe-in -49.8, -37.77 -23.43, -57.21 APE12-dist-in 8.119 APE11-dist-out 7.643 APE10-dist-out 12.951 APE9-dist-out 9.418 None None None XRAY 2.65 0.24 0.291 E 373 308 52 0 0 0 [[69, 379]] 1.0 2wtk Homo sapiens STE_STRADA_HUMAN STE 4e-87 298.0 1 257 257 212 213 214 216 218 100 118 122 192 194 193 195 261 247 242 241 240 239 238 237 236 148 STE20-related kinase adapter protein alpha
STE TNIK TNIK_HUMAN 7XZRB Q9UKE5 12 312 1360.0 ANP:1401 ATPlike Active DFGin 6.439 15.163 BLAminus -131.61, 176.54 70.33, 83.31 -101.27, 21.61 286.01, 77.74 -67.8, -30.96 in-in in 9.126 Saltbr-in 2.582 HRD-in -64.36, -58.64 76.74, 3.35 in-in-in SNCiii in-in ActLoopNT-in 2.931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.27, 150.43 APE9-dihe-na 126.35, -168.16 APE8-dihe-in -105.07, 123.33 APE8-rot-in 308.43 APE67-dihe-in -61.4, -25.19 -44.62, -54.45 APE12-dist-in 8.7 APE11-dist-in 11.705 APE10-dist-in 6.078 APE9-dist-in 3.705 None TPO181,TPO187 TPO181,TPO187 XRAY 2.26 0.184 0.226 B 306 301 0 0 0 0 [[25, 289]] 1.0 7xzr Homo sapiens STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 7XZRA Q9UKE5 12 310 1360.0 ANP:1401 Type1.5_Front Active DFGin 6.274 14.193 BLAminus -134.39, 177.59 74.52, 87.23 -110.98, 20.38 291.6, 89.06 -61.78, -40.23 in-in in 8.591 Saltbr-in 2.844 HRD-in -69.77, -51.11 71.86, 1.74 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.22, 154.28 APE9-dihe-na 131.69, -173.17 APE8-dihe-in -101.89, 120.07 APE8-rot-in 317.88 APE67-dihe-in -57.93, -30.58 -42.35, -51.61 APE12-dist-in 8.595 APE11-dist-in 12.046 APE10-dist-in 6.44 APE9-dist-in 4.307 None TPO181,TPO187 TPO181,TPO187 XRAY 2.26 0.184 0.226 A 306 299 0 0 0 0 [[25, 289]] 1.0 7xzr Homo sapiens STE_TNIK_HUMAN STE 3e-105 357.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TKL ACVR1 ACVR1_HUMAN 6UNQA Q04771 206 496 509.0 ANP:501 ATPlike Inactive DFGin 7.42 13.337 BLAminus -125.65, 175.43 76.87, 82.94 -97.73, 22.73 293.77, 158.03 -74.66, -11.32 in-out in 8.409 Saltbr-out 4.371 HRD-in -82.52, -56.03 82.09, -4.01 out-in-out SNCoio in-out ActLoopNT-in 2.814 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -122.89, 171.23 APE9-dihe-na -69.6, 161.61 APE8-dihe-in -54.69, 120.18 APE8-rot-in 304.53 APE67-dihe-in -58.55, -27.57 -58.47, -38.91 APE12-dist-in 10.463 APE11-dist-out 6.668 APE10-dist-out 9.075 APE9-dist-in 3.923 K493A None None XRAY 2.4 0.221 0.283 A 330 289 3 0 0 0 [[207, 497]] 1.0 6unq Homo sapiens TKL_ACVR1_HUMAN TKL 5e-85 291.3 2 266 265 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 6UNRA Q04771 208 496 509.0 ANP:501 ATPlike Inactive DFGin 7.292 13.342 BLAminus -137.01, 173.22 63.77, 86.25 -97.63, 26.62 300.72, 163.44 -66.11, -21.39 in-out in 8.4 Saltbr-out 4.744 HRD-in -74.93, -61.2 87.34, -7.73 out-in-out SNCoio in-out ActLoopNT-in 2.837 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -115.39, 160.07 APE9-dihe-na -63.13, 170.03 APE8-dihe-in -59.34, 121.87 APE8-rot-in 302.11 APE67-dihe-in -65.55, -35.42 -57.38, -33.57 APE12-dist-in 10.451 APE11-dist-out 6.838 APE10-dist-out 9.11 APE9-dist-in 3.93 None None None XRAY 2.2 0.246 0.302 A 330 286 4 0 0 0 [[207, 497]] 1.0 6unr Homo sapiens TKL_ACVR1_HUMAN TKL 7.3e-85 290.8 2 266 265 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ARAF ARAF_HUMAN 9AXMB P10398 302 574 606.0 ANP:60602 ATPlike Inactive DFGin 4.597 13.327 BLBplus -134.26, 172.61 61.7, 46.72 -103.54, 150.88 54.31, 89.4 54.71, 36.64 out-out out 11.556 Saltbr-out 10.494 HRD-in -66.55, -46.59 76.65, -12.19 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -153.94 APE8-dihe-in -77.25, 142.54 APE8-rot-out 182.59 APE67-dihe-in -67.09, -22.55 -72.82, -26.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.524 Y301D,Y302D None None XRAY 2.42 0.263 0.301 B 280 254 19 0 0 17 [[310, 569]] 1.0 9axm Homo sapiens TKL_ARAF_HUMAN TKL 1.1e-77 267.1 2 266 265 446 447 448 450 452 336 354 358 426 428 427 429 491 476 471 470 469 468 467 466 465 383 Serine/threonine-protein kinase A-Raf
TKL BRAF BRAF_HUMAN 9AXXB P15056 449 721 766.0 ANP:60801 ATPlike Inactive DFGin 6.272 14.156 BLAminus -118.96, -160.68 44.13, 79.21 -91.3, 29.71 285.28, 70.2 -64.85, -24.03 in-out in 8.968 Saltbr-out 6.042 HRD-in -74.42, -44.59 66.93, 5.21 out-in-in SNCoii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.1, 120.32 APE9-dihe-na 137.74, -165.97 APE8-dihe-in -102.01, 122.38 APE8-rot-in 304.65 APE67-dihe-in -63.13, -30.61 -66.04, -26.1 APE12-dist-in 13.099 APE11-dist-in 12.628 APE10-dist-in 7.472 APE9-dist-in 5.708 None None None XRAY 2.07 0.215 0.248 B 280 261 12 0 0 6 [[457, 716]] 1.0 9axx Homo sapiens TKL_BRAF_HUMAN TKL 7.8e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 9AXYA P15056 448 722 766.0 ANP:801 ATPlike Inactive DFGin 5.917 13.541 BLBplus -133.51, 174.13 59.27, 33.71 -86.77, 154.56 49.71, 87.92 69.37, -142.48 out-out out 14.096 Saltbr-out 13.007 HRD-in -70.93, -41.64 75.57, -39.02 out-out-out SNCooo out-out ActLoopNT-out 9.069 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -141.06, 145.96 APE9-dihe-na 71.75, -130.61 APE8-dihe-in -87.56, 149.58 APE8-rot-out 200.58 APE67-dihe-in -69.57, -29.74 -96.77, -9.15 APE12-dist-out 14.194 APE11-dist-out 15.515 APE10-dist-out 11.663 APE9-dist-out 9.677 None None None XRAY 3.6 0.19 0.237 A 280 275 0 0 0 0 [[457, 716]] 1.0 9axy Homo sapiens TKL_BRAF_HUMAN TKL 7.8e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 6PP9A P15056 447 722 766.0 ANP:801 ATPlike Inactive DFGin 5.342 13.498 BLBplus -130.79, 177.54 57.37, 43.96 -96.57, 156.54 49.86, 89.0 63.47, -135.71 out-out out 14.313 Saltbr-out 12.69 HRD-in -66.97, -47.8 65.51, 3.6 out-out-out SNCooo out-out ActLoopNT-out 9.256 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -142.44, 146.23 APE9-dihe-na 73.26, -154.57 APE8-dihe-in -71.36, 154.2 APE8-rot-out 182.15 APE67-dihe-in -61.64, -19.53 -112.25, -5.75 APE12-dist-out 15.201 APE11-dist-out 15.9 APE10-dist-out 12.693 APE9-dist-out 10.139 None None None XRAY 2.59 0.222 0.245 A 283 276 0 0 0 0 [[457, 716]] 1.0 6pp9 Homo sapiens TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 6V2WA P15056 447 721 766.0 ANP:801 ATPlike Inactive DFGin 5.532 13.704 BLBplus -135.72, 175.83 57.63, 35.46 -91.96, 158.82 53.8, 96.09 64.15, -137.39 out-out out 14.475 Saltbr-out 12.433 HRD-in -69.37, -44.53 66.04, 8.13 out-out-out SNCooo out-out ActLoopNT-out 8.99 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -146.39, 170.31 APE9-dihe-na 111.41, -172.95 APE8-dihe-in -92.84, 135.37 APE8-rot-out 52.69 APE67-dihe-in -65.1, -26.74 -72.43, -22.76 APE12-dist-out 14.729 APE11-dist-out 14.898 APE10-dist-out 12.159 APE9-dist-out 6.256 None None None XRAY 3.12 0.189 0.237 A 283 275 0 0 0 0 [[457, 716]] 1.0 6v2w Homo sapiens TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0TA P15056 448 721 766.0 ANP:801 ATPlike Inactive DFGin 5.483 13.645 BLBplus -101.53, -171.54 49.12, 40.35 -93.39, 158.36 49.68, 91.24 67.74, -141.33 out-out out 14.633 Saltbr-out 13.418 HRD-in -63.36, -50.98 81.19, -14.99 out-out-out SNCooo out-out ActLoopNT-out 9.096 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iooo APE10-dihe-na -146.63, 169.35 APE9-dihe-na 113.78, -178.56 APE8-dihe-in -87.12, 141.18 APE8-rot-out 208.64 APE67-dihe-out -59.38, 160.81 -70.93, -34.96 APE12-dist-in 13.663 APE11-dist-out 15.277 APE10-dist-out 12.449 APE9-dist-out 6.689 None None None XRAY 3.19 0.199 0.254 A 283 274 0 0 0 0 [[457, 716]] 1.0 7m0t Homo sapiens TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0UA P15056 449 722 766.0 ANP:801 ATPlike Inactive DFGin 5.826 13.545 BLBplus -114.76, -174.76 53.19, 33.71 -86.73, 158.23 49.19, 93.22 61.58, -136.88 out-out out 14.508 Saltbr-out 13.628 HRD-in -66.62, -51.93 79.28, -5.3 out-out-out SNCooo out-out ActLoopNT-out 8.968 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -137.94, 171.17 APE9-dihe-na 125.59, 173.92 APE8-dihe-in -78.53, 136.46 APE8-rot-out 49.62 APE67-dihe-in -63.36, -26.84 -75.55, -22.51 APE12-dist-out 14.59 APE11-dist-out 14.476 APE10-dist-out 12.102 APE9-dist-out 6.331 None None None XRAY 3.09 0.193 0.23 A 283 274 0 0 0 0 [[457, 716]] 1.0 7m0u Homo sapiens TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0VA P15056 449 722 766.0 ANP:801 ATPlike Inactive DFGin 5.741 13.29 BLBplus -118.84, -178.01 61.17, 44.22 -99.98, 160.93 40.29, 99.45 62.33, -140.62 out-out out 14.111 Saltbr-out 13.141 HRD-in -76.68, -47.66 79.51, -34.29 out-out-out SNCooo out-out ActLoopNT-out 9.324 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -140.71, 145.59 APE9-dihe-na 81.77, -131.39 APE8-dihe-in -106.29, 148.31 APE8-rot-out 201.4 APE67-dihe-in -54.29, -30.39 -107.29, -13.89 APE12-dist-in 13.909 APE11-dist-out 15.777 APE10-dist-out 12.613 APE9-dist-out 10.163 None None None XRAY 3.16 0.188 0.234 A 283 274 0 0 0 0 [[457, 716]] 1.0 7m0v Homo sapiens TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0WA P15056 448 721 766.0 ANP:801 ATPlike Inactive DFGin 5.7 13.563 BLBplus -128.57, -174.24 58.52, 36.11 -93.32, 163.98 47.26, 91.72 57.0, -141.37 out-out out 14.273 Saltbr-out 13.044 HRD-in -64.47, -50.11 78.2, -6.17 out-out-out SNCooo out-out ActLoopNT-out 8.98 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -140.16, 158.71 APE9-dihe-na 121.26, -178.69 APE8-dihe-in -87.94, 138.93 APE8-rot-out 43.99 APE67-dihe-in -65.6, -30.89 -79.08, -13.62 APE12-dist-out 14.335 APE11-dist-out 15.342 APE10-dist-out 12.134 APE9-dist-out 6.651 None None None XRAY 3.09 0.197 0.233 A 283 274 0 0 0 0 [[457, 716]] 1.0 7m0w Homo sapiens TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0XA P15056 447 722 766.0 ANP:801 ATPlike Inactive DFGin 5.445 13.495 BLBplus -123.82, 174.92 60.79, 42.33 -96.45, 161.16 49.04, 90.67 58.85, -140.33 out-out out 14.265 Saltbr-out 13.063 HRD-in -65.53, -50.34 78.03, -10.0 out-out-out SNCooo out-out ActLoopNT-out 9.245 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -141.24, 149.26 APE9-dihe-na 65.43, -162.66 APE8-dihe-in -61.59, 142.77 APE8-rot-out 179.57 APE67-dihe-in -62.52, -26.23 -97.92, -3.07 APE12-dist-out 15.152 APE11-dist-out 15.966 APE10-dist-out 12.626 APE9-dist-out 10.084 None None None XRAY 2.47 0.18 0.215 A 283 276 0 0 0 0 [[457, 716]] 1.0 7m0x Homo sapiens TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0YA P15056 447 721 766.0 ANP:801 ATPlike Inactive DFGin 5.925 13.72 BLBplus -130.12, 178.08 53.67, 39.87 -94.09, 143.26 51.07, 86.66 77.46, -140.33 out-out out 14.454 Saltbr-out 12.42 HRD-in -66.6, -53.86 81.89, -14.1 out-out-out SNCooo out-out ActLoopNT-out 8.968 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -138.96, 162.77 APE9-dihe-na 110.62, -175.34 APE8-dihe-in -77.87, 138.5 APE8-rot-out 52.44 APE67-dihe-in -64.93, -32.89 -83.52, -17.07 APE12-dist-out 14.226 APE11-dist-out 15.27 APE10-dist-out 12.007 APE9-dist-out 6.781 None None None XRAY 3.45 0.196 0.218 A 283 275 0 0 0 0 [[457, 716]] 1.0 7m0y Homo sapiens TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 7M0ZA P15056 449 721 766.0 ANP:801 ATPlike Inactive DFGin 5.591 13.558 BLBplus -131.23, -177.35 57.24, 31.09 -88.02, 155.4 49.99, 89.35 66.37, -137.56 out-out out 14.378 Saltbr-out 12.797 HRD-in -63.1, -49.11 70.7, -2.29 out-out-out SNCooo out-out ActLoopNT-out 8.934 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -140.88, 158.66 APE9-dihe-na 126.45, -167.01 APE8-dihe-in -93.79, 132.25 APE8-rot-out 208.38 APE67-dihe-in -66.35, -24.31 -75.16, -20.55 APE12-dist-in 12.987 APE11-dist-out 14.918 APE10-dist-out 11.822 APE9-dist-out 6.385 None None None XRAY 3.12 0.193 0.225 A 283 273 0 0 0 0 [[457, 716]] 1.0 7m0z Homo sapiens TKL_BRAF_HUMAN TKL 8.1e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 9ECUA P15056 447 722 766.0 ANP:801 ATPlike Inactive DFGin 5.395 13.556 BLBplus -125.65, 169.46 60.46, 40.01 -87.45, 154.95 47.27, 91.45 64.75, -132.56 out-out out 13.975 Saltbr-out 13.736 HRD-in -64.53, -58.29 87.19, -19.63 out-out-out SNCooo out-out ActLoopNT-out 9.233 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -128.75, 123.72 APE9-dihe-na 163.56, -169.21 APE8-dihe-in -104.16, 118.8 APE8-rot-in 298.64 APE67-dihe-in -60.82, -35.98 -59.26, -34.28 APE12-dist-out 14.691 APE11-dist-out 15.132 APE10-dist-out 11.51 APE9-dist-out 6.31 None None None XRAY 3.46 0.202 0.237 A 284 276 0 0 0 0 [[457, 716]] 1.0 9ecu Homo sapiens TKL_BRAF_HUMAN TKL 8.2e-82 280.6 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL IRAK4 IRAK4_HUMAN 2OIDA Q9NWZ3 164 458 460.0 ANP:1 ATPlike Inactive DFGin 6.966 14.684 BLAminus -127.55, 175.38 65.24, 82.27 -102.22, 23.11 306.08, 83.19 -64.75, -29.47 out-out out 11.832 Saltbr-out 5.69 HRD-in -73.12, -50.9 80.09, -6.55 out-in-in SNCoii in-in ActLoopNT-in 2.823 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.88, 151.66 APE9-dihe-na 147.16, -164.5 APE8-dihe-in -113.74, 115.19 APE8-rot-in 308.34 APE67-dihe-in -64.44, -17.27 -37.39, -54.71 APE12-dist-in 9.826 APE11-dist-in 11.538 APE10-dist-in 6.072 APE9-dist-in 3.807 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.244 0.295 A 301 266 29 0 0 4 [[183, 456]] 1.0 2oid Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OIDB Q9NWZ3 164 459 460.0 ANP:2 ATPlike Inactive DFGin 6.94 14.71 BLAminus -122.34, 171.98 72.6, 82.12 -104.43, 15.54 299.16, 90.11 -59.64, -29.05 in-out in 8.908 Saltbr-out 3.93 HRD-in -75.58, -47.6 78.52, -5.87 out-in-in SNCoii in-in ActLoopNT-in 2.73 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.71, 158.05 APE9-dihe-na 142.8, -157.21 APE8-dihe-in -121.23, 117.8 APE8-rot-in 309.19 APE67-dihe-in -67.67, -11.87 -44.28, -49.35 APE12-dist-in 10.19 APE11-dist-in 11.743 APE10-dist-in 6.522 APE9-dist-in 3.723 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.244 0.295 B 301 274 22 0 0 6 [[183, 456]] 1.0 2oid Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OIDC Q9NWZ3 166 458 460.0 ANP:3 ATPlike Inactive DFGin 6.806 13.973 BLAminus -130.4, 175.52 61.07, 75.53 -96.05, 32.37 309.84, 82.72 -74.67, -28.22 in-out in 8.901 Saltbr-out 4.024 HRD-in -62.6, -55.98 80.8, 1.53 out-in-in SNCoii in-in ActLoopNT-in 3.032 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.92, 158.28 APE9-dihe-na 138.01, -176.06 APE8-dihe-in -106.21, 116.22 APE8-rot-in 304.08 APE67-dihe-in -63.21, -15.57 -55.27, -41.4 APE12-dist-in 9.687 APE11-dist-in 11.42 APE10-dist-in 6.361 APE9-dist-in 3.878 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.244 0.295 C 301 259 34 0 0 6 [[183, 456]] 1.0 2oid Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 2OIDD Q9NWZ3 164 459 460.0 ANP:4 ATPlike Active DFGin 6.56 13.972 BLAminus -129.12, -177.03 59.13, 109.88 -131.38, 17.54 304.54, 87.5 -68.37, -4.63 in-in in 8.15 Saltbr-in 3.52 HRD-in -75.54, -51.34 70.58, 2.03 in-in-in SNCiii in-in ActLoopNT-in 2.765 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.72, 147.52 APE9-dihe-na 139.0, -173.6 APE8-dihe-in -107.1, 118.58 APE8-rot-in 309.04 APE67-dihe-in -62.68, -15.82 -47.4, -49.91 APE12-dist-in 9.75 APE11-dist-in 11.44 APE10-dist-in 5.928 APE9-dist-in 3.97 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.3 0.244 0.295 D 301 277 19 0 0 3 [[183, 456]] 1.0 2oid Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6EGFB Q9NWZ3 164 460 460.0 ANP:501 ATPlike Inactive DFGin 5.613 16.883 BLBtrans -116.63, 167.73 64.0, 27.84 -68.07, 138.11 161.96, 71.15 80.16, -16.86 out-out out 13.646 Saltbr-out 13.39 HRD-in -72.08, -42.87 70.74, 1.24 out-out-out SNCooo out-out ActLoopNT-out 6.113 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 31.47 APE8-rot-out 178.98 APE67-dihe-in -65.08, -16.47 -76.23, -17.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.61 0.206 0.229 B 302 285 12 0 0 12 [[183, 456]] 1.0 6egf Homo sapiens TKL_IRAK4_HUMAN TKL 2.6e-83 285.5 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL KSR1 KSR1_HUMAN 9AXHC Q8IVT5 614 881 923.0 ANP:60901 ATPlike Pseudo DFGin 5.23 13.239 BLBplus -124.42, 164.81 64.66, 43.46 -90.48, 143.73 53.91, 91.43 61.22, 55.23 out-none out 14.31 Saltbr-none 999.0 HRD-in -67.1, -51.8 77.02, -11.89 none-out-out SNCnoo out-out ActLoopNT-out 7.657 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -64.2, -39.05 APE9-dihe-na -59.17, -48.89 APE8-dihe-out -66.09, -38.64 APE8-rot-na 184.07 APE67-dihe-in -61.76, -22.42 -60.74, -36.73 APE12-dist-out 16.89 APE11-dist-out 15.959 APE10-dist-out 20.499 APE9-dist-out 12.219 None None None XRAY 2.81 0.206 0.253 C 283 259 10 0 0 7 [[613, 879]] 1.0 9axh Homo sapiens TKL_KSR1_HUMAN TKL 2.1e-68 236.7 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 9AXHD Q8IVT5 613 881 923.0 ANP:60901 ATPlike Pseudo DFGin 5.246 13.229 BLBplus -126.56, 169.35 63.03, 47.69 -96.52, 141.09 54.28, 88.59 76.52, 29.36 out-none out 14.488 Saltbr-none 999.0 HRD-in -67.9, -47.78 73.32, -2.62 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -60.7, -40.23 APE9-dihe-na -60.83, -42.14 APE8-dihe-out -70.49, -38.33 APE8-rot-na 183.99 APE67-dihe-in -64.38, -16.08 -60.51, -36.42 APE12-dist-out 17.087 APE11-dist-out 16.228 APE10-dist-out 20.701 APE9-dist-out 12.597 None None None XRAY 2.81 0.206 0.253 D 283 249 20 0 0 13 [[613, 879]] 1.0 9axh Homo sapiens TKL_KSR1_HUMAN TKL 2.1e-68 236.7 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JUWB Q8IVT5 601 881 923.0 ANP:901 ATPlike Pseudo DFGin 5.479 13.436 BLBplus -116.78, 175.7 58.02, 37.9 -91.13, 161.87 61.57, 85.28 62.4, -8.11 out-none out 13.34 Saltbr-none 999.0 HRD-in -64.36, -50.52 68.6, 3.9 none-out-out SNCnoo out-out ActLoopNT-out 7.126 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -75.12, -46.44 APE9-dihe-na -49.25, -41.63 APE8-dihe-out -65.16, -50.29 APE8-rot-na 182.96 APE67-dihe-in -55.58, -30.38 -61.8, -31.6 APE12-dist-out 17.682 APE11-dist-out 16.599 APE10-dist-out 21.026 APE9-dist-out 12.834 None None None XRAY 2.88 0.245 0.286 B 334 277 4 0 0 4 [[613, 879]] 1.0 7juw Homo sapiens TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JUXA Q8IVT5 600 881 923.0 ANP:901 ATPlike Pseudo DFGin 5.302 12.887 BLBplus -130.76, 153.55 60.79, 41.41 -77.85, 152.64 59.13, 80.46 58.16, 12.6 out-none out 13.586 Saltbr-none 999.0 HRD-out -82.48, 84.18 -62.97, 148.26 none-out-out SNCnoo out-out ActLoopNT-out 7.062 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -85.2, -42.07 APE9-dihe-na -55.8, -29.41 APE8-dihe-out -77.82, -37.67 APE8-rot-na 188.53 APE67-dihe-in -61.89, -19.45 -62.94, -36.24 APE12-dist-out 17.427 APE11-dist-out 16.235 APE10-dist-out 20.624 APE9-dist-out 14.057 None None None XRAY 3.34 0.265 0.283 A 334 278 4 0 0 4 [[613, 879]] 1.0 7jux Homo sapiens TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JUYB Q8IVT5 601 881 923.0 ANP:901 ATPlike Pseudo DFGin 5.613 13.191 BLBplus -117.18, 175.18 57.71, 38.02 -91.22, 161.18 61.47, 85.63 62.09, -7.96 out-none out 13.395 Saltbr-none 999.0 HRD-in -64.77, -50.93 68.2, 3.89 none-out-out SNCnoo out-out ActLoopNT-out 7.067 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -74.87, -46.12 APE9-dihe-na -49.26, -41.38 APE8-dihe-out -64.88, -49.41 APE8-rot-na 183.95 APE67-dihe-in -56.03, -30.73 -61.35, -31.75 APE12-dist-out 17.556 APE11-dist-out 16.525 APE10-dist-out 20.947 APE9-dist-out 12.77 None None None XRAY 3.096 0.248 0.257 B 334 276 5 0 0 5 [[613, 879]] 1.0 7juy Homo sapiens TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JUZA Q8IVT5 601 881 923.0 ANP:901 ATPlike Pseudo DFGin 5.251 13.144 BLBplus -120.58, 157.85 65.97, 36.71 -81.68, 149.84 60.82, 87.44 61.36, 0.32 out-none out 13.842 Saltbr-none 999.0 HRD-in -63.05, -49.06 69.65, 1.96 none-out-out SNCnoo out-out ActLoopNT-out 6.963 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -71.77, -43.35 APE9-dihe-na -54.66, -39.8 APE8-dihe-out -69.49, -39.39 APE8-rot-na 184.11 APE67-dihe-in -64.95, -32.88 -59.75, -32.59 APE12-dist-out 17.573 APE11-dist-out 16.418 APE10-dist-out 20.831 APE9-dist-out 12.592 None None None XRAY 3.21 0.255 0.272 A 334 273 8 0 0 8 [[613, 879]] 1.0 7juz Homo sapiens TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JV0A Q8IVT5 601 881 923.0 ANP:901 ATPlike Pseudo DFGin 5.544 13.231 BLBplus -113.37, 179.62 53.84, 36.37 -87.67, 157.34 63.1, 86.33 73.66, -16.65 out-none out 13.335 Saltbr-none 999.0 HRD-in -63.7, -53.29 73.57, 2.92 none-out-out SNCnoo out-out ActLoopNT-out 7.005 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -74.36, -44.01 APE9-dihe-na -53.64, -41.33 APE8-dihe-out -66.6, -51.73 APE8-rot-na 184.61 APE67-dihe-in -59.37, -29.99 -47.75, -40.44 APE12-dist-out 17.632 APE11-dist-out 16.659 APE10-dist-out 21.083 APE9-dist-out 12.781 None None None XRAY 3.63 0.247 0.26 A 334 276 5 0 0 5 [[613, 879]] 1.0 7jv0 Homo sapiens TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR1 KSR1_HUMAN 7JV1D Q8IVT5 600 881 923.0 ANP:901 ATPlike Pseudo DFGin 4.998 13.028 BLBplus -130.92, 154.93 60.0, 40.35 -76.18, 155.67 58.85, 79.94 54.95, 12.06 out-none out 13.786 Saltbr-none 999.0 HRD-out -81.07, 84.18 -62.62, 147.5 none-out-out SNCnoo out-out ActLoopNT-out 6.808 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -83.95, -45.7 APE9-dihe-na -55.75, -29.37 APE8-dihe-out -76.69, -37.65 APE8-rot-na 188.09 APE67-dihe-in -60.65, -19.03 -62.72, -36.82 APE12-dist-out 17.487 APE11-dist-out 16.348 APE10-dist-out 20.808 APE9-dist-out 14.145 None None None XRAY 3.62 0.278 0.303 D 334 275 7 0 0 7 [[613, 879]] 1.0 7jv1 Homo sapiens TKL_KSR1_HUMAN TKL 3.8e-68 235.9 2 267 266 749 750 751 753 755 639 657 661 730 732 731 733 803 782 777 776 775 774 773 772 771 687 Kinase suppressor of Ras 1
TKL KSR2 KSR2_HUMAN 7JURB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.534 13.444 BLBplus -136.74, 172.29 64.43, 21.01 -64.29, 145.08 51.43, 88.21 72.32, -17.93 out-none out 13.058 Saltbr-none 999.0 HRD-in -74.46, -55.37 71.55, 3.38 none-out-out SNCnoo out-out ActLoopNT-out 7.607 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -61.97, 131.45 APE9-dihe-na 84.3, -3.37 APE8-dihe-out -70.0, -57.71 APE8-rot-na 184.79 APE67-dihe-in -71.0, 1.52 -53.02, -42.72 APE12-dist-out 18.483 APE11-dist-out 15.136 APE10-dist-out 19.742 APE9-dist-out 12.323 None None None XRAY 2.82 0.237 0.277 B 342 277 4 0 0 3 [[665, 930]] 1.0 7jur Homo sapiens TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JUSB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.883 13.383 BLBplus -127.91, 171.08 62.77, 22.74 -63.47, 150.27 47.2, 86.11 68.89, -21.25 out-none out 13.513 Saltbr-none 999.0 HRD-in -73.66, -56.88 73.44, -2.22 none-out-out SNCnoo out-out ActLoopNT-out 7.508 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -57.38, 137.79 APE9-dihe-na 90.37, -24.33 APE8-dihe-out -66.74, -57.02 APE8-rot-na 187.61 APE67-dihe-in -75.11, -1.38 -58.95, -34.29 APE12-dist-out 18.421 APE11-dist-out 15.077 APE10-dist-out 19.629 APE9-dist-out 12.036 None None None XRAY 2.99 0.249 0.265 B 342 276 5 0 0 4 [[665, 930]] 1.0 7jus Homo sapiens TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JUTB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.556 12.961 BLBplus -137.17, 153.82 70.92, 32.74 -74.86, 135.77 48.5, 88.18 74.13, -4.82 out-none out 14.209 Saltbr-none 999.0 HRD-in -85.35, -39.03 46.26, 13.05 none-out-out SNCnoo out-out ActLoopNT-out 7.196 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -53.57, -55.36 APE9-dihe-na -91.09, 3.18 APE8-dihe-out -71.8, -46.41 APE8-rot-na 181.21 APE67-dihe-in -68.18, -7.53 -62.86, -41.09 APE12-dist-out 18.127 APE11-dist-out 15.431 APE10-dist-out 19.558 APE9-dist-out 11.925 None None None XRAY 3.09 0.259 0.3 B 342 277 4 0 0 3 [[665, 930]] 1.0 7jut Homo sapiens TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JUUB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.773 13.221 BLBplus -133.64, 151.36 70.73, 33.64 -75.25, 133.98 46.29, 83.15 80.08, -8.46 out-none out 14.433 Saltbr-none 999.0 HRD-in -73.56, -47.69 67.59, 2.06 none-out-out SNCnoo out-out ActLoopNT-out 7.385 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -58.47, -51.54 APE9-dihe-na -86.76, 0.87 APE8-dihe-out -74.62, -44.43 APE8-rot-na 183.38 APE67-dihe-in -73.96, -6.37 -64.52, -36.97 APE12-dist-out 18.347 APE11-dist-out 15.59 APE10-dist-out 19.794 APE9-dist-out 12.093 None None None XRAY 3.19 0.242 0.258 B 342 277 4 0 0 3 [[665, 930]] 1.0 7juu Homo sapiens TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7JUVB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.981 13.017 BLBplus -127.69, 170.94 63.29, 22.28 -64.16, 148.8 47.81, 86.58 68.48, -22.21 out-none out 13.605 Saltbr-none 999.0 HRD-in -73.05, -56.86 73.65, -2.34 none-out-out SNCnoo out-out ActLoopNT-out 7.503 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -57.84, 138.27 APE9-dihe-na 90.88, -24.23 APE8-dihe-out -67.14, -55.82 APE8-rot-na 188.73 APE67-dihe-in -75.46, -2.03 -58.92, -34.4 APE12-dist-out 18.296 APE11-dist-out 15.175 APE10-dist-out 19.835 APE9-dist-out 12.199 None None None XRAY 3.36 0.242 0.255 B 342 277 4 0 0 3 [[665, 930]] 1.0 7juv Homo sapiens TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL KSR2 KSR2_HUMAN 7UMBB Q6VAB6 652 932 950.0 ANP:1001 ATPlike Pseudo DFGin 5.511 13.333 BLBplus -122.69, -178.17 55.62, 31.28 -75.96, 141.02 47.41, 88.89 74.01, -10.38 out-none out 13.077 Saltbr-none 999.0 HRD-in -83.2, -50.32 69.21, 5.46 none-out-out SNCnoo out-out ActLoopNT-out 7.53 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -52.68, 124.31 APE9-dihe-na 106.73, -20.32 APE8-dihe-out -71.55, -49.08 APE8-rot-na 185.38 APE67-dihe-in -79.33, 2.43 -65.58, -32.18 APE12-dist-out 18.119 APE11-dist-out 15.398 APE10-dist-out 19.723 APE9-dist-out 12.009 None None None XRAY 3.231 0.231 0.268 B 342 277 4 0 0 3 [[665, 930]] 1.0 7umb Homo sapiens TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL LIMK1 LIMK1_HUMAN 5HVJA P53667 329 633 647.0 ANP:1000 ATPlike Inactive DFGin 6.167 14.018 BLAminus -132.74, -177.4 60.53, 87.07 -109.1, 23.76 308.69, 90.48 -66.78, -25.98 in-in in 8.119 Saltbr-in 2.787 HRD-in -65.97, -50.93 68.53, 0.88 in-in-out SNCiio in-out ActLoopNT-in 2.943 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oiio APE10-dihe-na -124.58, 95.6 APE9-dihe-na 76.06, -115.03 APE8-dihe-in -111.26, 122.06 APE8-rot-na 224.18 APE67-dihe-in -69.88, -30.27 -73.34, -10.37 APE12-dist-out 14.758 APE11-dist-in 11.813 APE10-dist-in 6.925 APE9-dist-out 6.372 D460N None None XRAY 2.2 0.208 0.252 A 315 283 22 0 0 22 [[339, 606]] 1.0 5hvj Homo sapiens TKL_LIMK1_HUMAN TKL 3e-76 262.4 3 266 264 477 478 479 481 483 368 384 388 457 459 458 460 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL LIMK1 LIMK1_HUMAN 5HVKA P53667 329 634 647.0 ANP:61001 ATPlike Active DFGin 6.405 13.646 BLAminus -145.46, 176.84 65.07, 82.49 -109.26, 24.73 304.62, 92.73 -71.79, -22.73 in-in in 7.795 Saltbr-in 3.159 HRD-in -70.8, -44.42 59.42, 18.52 in-in-in SNCiii in-in ActLoopNT-in 3.324 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -139.63, 151.17 APE9-dihe-na 143.88, 171.7 APE8-dihe-in -71.51, 120.27 APE8-rot-na 199.31 APE67-dihe-in -66.59, -36.22 -54.03, -34.34 APE12-dist-in 9.301 APE11-dist-in 11.081 APE10-dist-in 5.636 APE9-dist-in 3.574 D460N TPO508 TPO508 XRAY 3.5 0.275 0.31 A 315 293 13 0 0 13 [[339, 606]] 1.0 5hvk Homo sapiens TKL_LIMK1_HUMAN TKL 3e-76 262.4 3 266 264 477 478 479 481 483 368 384 388 457 459 458 460 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL LIMK1 LIMK1_HUMAN 5HVKC P53667 329 633 647.0 ANP:60701 ATPlike Inactive DFGin 6.078 13.934 None -149.69, 172.69 -101.87, 169.41 -110.21, 23.25 306.34, 92.8 -73.91, -25.16 in-out in 7.891 Saltbr-out 3.644 HRD-in -72.39, -44.63 59.79, 17.6 out-in-in SNCoii in-in ActLoopNT-in 3.07 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -140.53, 148.22 APE9-dihe-na 140.89, 172.08 APE8-dihe-in -72.12, 119.75 APE8-rot-na 199.66 APE67-dihe-in -64.48, -35.33 -54.5, -33.22 APE12-dist-in 8.669 APE11-dist-in 11.199 APE10-dist-in 5.899 APE9-dist-in 3.542 D460N TPO508 TPO508 XRAY 3.5 0.275 0.31 C 315 291 14 0 0 14 [[339, 606]] 1.0 5hvk Homo sapiens TKL_LIMK1_HUMAN TKL 3e-76 262.4 3 266 264 477 478 479 481 483 368 384 388 457 459 458 460 531 519 514 513 512 511 510 509 508 414 LIM domain kinase 1
TKL LRRK2 LRRK2_HUMAN 8VH5A Q5S007 12 2527 2527.0 ANP:2602 ATPlike Inactive DFGinter 9.746 8.455 None -88.01, 106.84 -81.35, 17.64 -78.83, -10.5 197.42, 64.93 -68.71, -22.79 out-out out 11.326 Saltbr-out 8.123 HRD-in -105.05, -49.61 72.56, -5.72 out-out-out SNCooo out-out ActLoopNT-out 8.961 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -67.06, -23.38 APE9-dihe-na 73.72, 168.0 APE8-dihe-in -68.8, 143.98 APE8-rot-out 58.99 APE67-dihe-in -65.74, -54.3 -73.05, -29.17 APE12-dist-in 9.633 APE11-dist-in 8.416 APE10-dist-out 13.344 APE9-dist-in 3.861 None None None EM 4.0 999.0 999.0 A 2527 2221 8 0 0 8 [[1875, 2134]] 1.0 8vh5 Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8VH5C Q5S007 12 2527 2527.0 ANP:2602 ATPlike Inactive DFGinter 9.746 8.455 None -88.01, 106.86 -81.36, 17.7 -78.84, -10.6 197.4, 64.92 -68.66, -22.76 out-out out 11.325 Saltbr-out 8.122 HRD-in -104.99, -49.63 72.52, -5.67 out-out-out SNCooo out-out ActLoopNT-out 8.961 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -66.98, -23.42 APE9-dihe-na 73.64, 168.02 APE8-dihe-in -68.73, 143.93 APE8-rot-out 59.0 APE67-dihe-in -65.76, -54.24 -73.07, -29.13 APE12-dist-in 9.633 APE11-dist-in 8.418 APE10-dist-out 13.345 APE9-dist-in 3.862 None None None EM 4.0 999.0 999.0 C 2527 2221 8 0 0 8 [[1875, 2134]] 1.0 8vh5 Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8VH4A Q5S007 12 2527 2527.0 ANP:2602 ATPlike Inactive None 999.0 999.0 None -94.14, 87.28 -74.17, 5.0 -60.35, -20.37 999.0, 999.0 -59.12, -33.8 out-none out 12.056 Saltbr-none 999.0 HRD-in -102.88, -51.08 73.15, -5.33 none-out-out SNCnoo out-out ActLoopNT-out 8.75 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -76.21, -33.07 APE9-dihe-na 74.7, 171.21 APE8-dihe-in -59.82, 149.42 APE8-rot-out 184.58 APE67-dihe-in -66.4, -59.35 -67.96, -43.48 APE12-dist-in 10.222 APE11-dist-in 9.448 APE10-dist-out 13.491 APE9-dist-in 4.057 None None None EM 4.1 999.0 999.0 A 2527 2235 8 0 0 8 [[1875, 2134]] 1.0 8vh4 Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL RAF1 RAF1_HUMAN 9AY7A P04049 343 612 648.0 ANP:701 ATPlike Inactive DFGin 5.805 13.462 BLBplus -133.55, 174.37 58.47, 38.44 -90.49, 142.18 44.05, 90.72 78.29, -134.9 out-out out 14.07 Saltbr-out 12.738 HRD-in -73.02, -44.7 76.86, -25.12 out-out-out SNCooo out-out ActLoopNT-out 9.182 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -145.48, 130.61 APE9-dihe-na 129.03, -169.57 APE8-dihe-in -79.63, 137.79 APE8-rot-in 302.79 APE67-dihe-in -63.4, -34.24 -69.33, -38.68 APE12-dist-out 15.236 APE11-dist-out 15.056 APE10-dist-out 10.624 APE9-dist-out 6.306 Y340D,Y341D None None XRAY 2.41 0.203 0.236 A 280 260 10 0 0 6 [[349, 608]] 1.0 9ay7 Homo sapiens TKL_RAF1_HUMAN TKL 2.6e-81 279.0 3 266 264 485 486 487 489 491 375 393 397 465 467 466 468 530 515 510 509 508 507 506 505 504 422 RAF proto-oncogene serine/threonine-protein kinase
TKL TGFBR2 TGFR2_HUMAN 5E92A P37173 240 543 567.0 ANP:601 ATPlike Active DFGin 7.396 13.303 BLAminus -134.93, 178.1 63.07, 87.04 -105.26, 16.76 300.78, 96.96 -60.58, -26.14 in-in in 7.67 Saltbr-in 2.752 HRD-in -64.87, -46.8 71.14, -4.53 in-in-in SNCiii in-in ActLoopNT-in 2.982 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.21, 144.17 APE9-dihe-na 126.96, -149.92 APE8-dihe-in -116.55, 119.38 APE8-rot-in 300.41 APE67-dihe-in -54.91, -33.03 -42.96, -45.47 APE12-dist-in 11.788 APE11-dist-in 12.049 APE10-dist-in 6.089 APE9-dist-in 3.401 E431A,R433A,E485A,K488A,R493A,R495A None None XRAY 2.08 0.204 0.231 A 316 298 6 0 0 0 [[244, 540]] 1.0 5e92 Homo sapiens TKL_TGFBR2_HUMAN TKL 1.9e-77 266.3 2 266 265 396 397 398 400 402 277 290 294 376 378 377 379 446 428 423 422 421 420 419 418 417 326 TGF-beta receptor type-2
TYR EGFR EGFR_HUMAN 3VJNA P00533 697 1018 1210.0 ANP:2001 ATPlike Inactive DFGin 6.07 15.553 BLAminus -140.47, -172.56 66.89, 81.42 -96.27, 22.36 285.26, 99.8 -61.68, -24.37 in-out in 8.864 Saltbr-out 4.159 HRD-in -62.92, -47.49 66.12, 0.14 out-in-in SNCoii in-in ActLoopNT-in 2.902 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.98, 116.83 APE9-dihe-in -113.71, 140.82 APE8-dihe-in -56.67, 106.47 APE8-rot-na 28.1 APE67-dihe-in -67.09, -6.37 -61.28, -43.59 APE12-dist-na 11.779 APE11-dist-na 9.748 APE10-dist-na 10.983 APE9-dist-in 5.988 G719S,T790M None None XRAY 2.34 0.197 0.244 A 334 297 4 0 0 0 [[712, 970]] 1.0 3vjn Homo sapiens TYR_EGFR_HUMAN TYR 7.9e-87 296.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8DSWA P00533 696 1017 1210.0 ANP:61104 ATPlike Inactive DFGin 5.926 15.858 BLAminus -139.88, -174.48 62.3, 80.03 -97.39, 21.12 300.26, 86.52 -53.52, -37.16 none-none none 999.0 Saltbr-none 999.0 HRD-in -81.01, -46.59 69.43, -1.39 none-in-none SNCnin in-none ActLoopNT-in 2.921 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 105.32 APE8-dihe-in -90.45, 95.73 APE8-rot-na 32.83 APE67-dihe-in -75.5, -1.32 -70.5, -35.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.219 None None None XRAY 2.39 0.197 0.246 A 335 301 12 0 0 9 [[712, 970]] 1.0 8dsw Homo sapiens TYR_EGFR_HUMAN TYR 1.9e-85 292.3 3 259 257 854 855 856 858 860 745 -9999 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITXA P00533 697 1019 1210.0 ANP:2020 ATPlike Active DFGin 5.874 15.737 BLAminus -136.31, -171.94 65.34, 93.22 -111.54, 18.75 298.27, 92.75 -59.44, 2.06 in-in in 9.241 Saltbr-in 3.583 HRD-in -62.41, -44.72 61.37, 7.79 in-in-in SNCiii in-in ActLoopNT-in 2.642 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.73, 124.39 APE9-dihe-in -125.4, 144.12 APE8-dihe-in -79.64, 94.32 APE8-rot-na 30.37 APE67-dihe-in -65.37, -0.17 -61.69, -47.61 APE12-dist-na 11.888 APE11-dist-na 10.151 APE10-dist-na 11.134 APE9-dist-in 7.058 None None None XRAY 2.98 0.191 0.261 A 327 307 4 0 0 4 [[712, 970]] 1.0 2itx Homo sapiens TYR_EGFR_HUMAN TYR 1e-87 299.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3VJOA P00533 696 1018 1210.0 ANP:2001 ATPlike Inactive DFGin 6.021 15.946 BLAminus -140.25, -165.5 56.51, 77.02 -90.26, 19.04 285.97, 94.98 -60.96, -7.67 in-out in 9.402 Saltbr-out 4.55 HRD-in -69.17, -43.62 63.06, 0.57 out-in-in SNCoii in-in ActLoopNT-in 2.921 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -101.49, 106.7 APE9-dihe-in -122.63, 146.56 APE8-dihe-in -79.91, 93.84 APE8-rot-na 34.61 APE67-dihe-in -67.26, -9.93 -59.74, -34.59 APE12-dist-na 12.246 APE11-dist-na 10.097 APE10-dist-na 10.762 APE9-dist-in 6.771 None None None XRAY 2.64 0.19 0.228 A 334 298 5 0 0 0 [[712, 970]] 1.0 3vjo Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-87 299.7 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITNA P00533 696 1019 1210.0 ANP:2021 ATPlike None DFGin 6.283 15.235 BLAminus -127.19, -173.38 63.95, 79.84 -96.65, 10.56 295.4, 91.5 -73.87, 28.38 in-in in 8.274 Saltbr-in 3.408 HRD-in -81.37, -44.82 70.79, -0.2 in-in-none SNCiin in-none ActLoopNT-in 2.843 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 98.73 APE8-dihe-in -79.18, 91.37 APE8-rot-na 30.4 APE67-dihe-in -69.96, -4.57 -72.15, -41.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.674 G719S None None XRAY 2.47 0.201 0.267 A 327 304 9 0 0 9 [[712, 970]] 1.0 2itn Homo sapiens TYR_EGFR_HUMAN TYR 9.6e-87 296.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2ITVA P00533 696 1019 1210.0 ANP:2020 ATPlike None DFGin 6.216 15.481 BLAminus -132.41, -173.63 61.69, 81.35 -94.21, 13.19 293.51, 90.37 -58.84, 7.8 in-in in 8.584 Saltbr-in 3.462 HRD-in -75.87, -46.5 68.4, 1.6 in-in-none SNCiin in-none ActLoopNT-in 2.737 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.23 APE8-dihe-in -83.21, 92.63 APE8-rot-na 31.24 APE67-dihe-in -66.41, -6.91 -75.93, -39.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.569 L858R None None XRAY 2.47 0.197 0.242 A 327 303 9 0 0 9 [[712, 970]] 1.0 2itv Homo sapiens TYR_EGFR_HUMAN TYR 1.1e-86 296.4 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2EB3A P00533 696 1018 1210.0 ANP:2001 ATPlike Inactive DFGin 4.666 14.869 BLAplus -146.31, -170.86 55.73, 31.55 -96.53, 44.19 45.64, 108.62 -72.56, -59.05 in-in in 8.594 Saltbr-in 3.443 HRD-out -53.85, 138.27 -123.62, 23.93 in-in-none SNCiin in-none ActLoopNT-in 2.585 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 154.55 APE8-dihe-in -88.38, 74.74 APE8-rot-na 41.16 APE67-dihe-in -67.41, -11.07 -62.2, -31.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.893 None None None XRAY 2.84 0.19 0.236 A 334 294 15 0 0 14 [[712, 970]] 1.0 2eb3 Homo sapiens TYR_EGFR_HUMAN TYR 1.2e-86 296.3 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1LB P00533 702 1008 1210.0 ANP:1102 ATPlike Inactive DFGin 4.326 15.477 BLBplus -134.87, 177.11 52.28, 41.66 -92.52, 151.37 118.41, 82.73 79.24, 7.39 out-out out 13.751 Saltbr-out 14.766 HRD-in -69.63, -50.82 67.27, 3.74 out-out-out SNCooo out-out ActLoopNT-out 8.694 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -67.98 APE8-dihe-in -90.55, 79.54 APE8-rot-na 36.74 APE67-dihe-in -76.92, -3.19 -66.82, -38.04 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.382 T790M,V948R None None XRAY 2.8 0.203 0.237 B 327 292 15 0 0 15 [[712, 970]] 1.0 6p1l Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6WAKA P00533 702 1013 1210.0 ANP:1101 ATPlike Inactive DFGin 3.68 14.038 BLBplus -119.87, 174.58 64.54, 16.96 -69.25, 144.86 73.85, 86.13 77.2, -6.44 out-out out 14.19 Saltbr-out 14.87 HRD-in -68.06, -64.5 89.93, -15.8 out-out-out SNCooo out-out ActLoopNT-out 6.056 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -95.75, -0.13 APE9-dihe-in -104.56, 101.78 APE8-dihe-in -62.85, 69.07 APE8-rot-na 27.65 APE67-dihe-in -73.63, -8.28 -54.79, -35.95 APE12-dist-na 999.0 APE11-dist-na 15.624 APE10-dist-na 11.34 APE9-dist-in 7.772 T790M,V948R None None XRAY 2.4 0.219 0.23 A 328 297 10 0 0 10 [[712, 970]] 1.0 6wak Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6WAKD P00533 701 1014 1210.0 ANP:1101 ATPlike Inactive DFGin 3.881 14.667 BLBplus -128.56, 164.59 71.9, 35.94 -89.47, 146.64 77.53, 95.38 87.93, -24.37 out-out out 13.753 Saltbr-out 11.845 HRD-in -75.5, -62.2 82.94, 0.35 out-out-out SNCooo out-out ActLoopNT-out 6.735 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.69 APE8-dihe-in -82.11, 67.25 APE8-rot-na 35.47 APE67-dihe-in -67.78, -4.44 -51.76, -45.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.046 T790M,V948R None None XRAY 2.4 0.219 0.23 D 328 297 17 0 0 14 [[712, 970]] 1.0 6wak Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8FV3A P00533 701 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 3.96 13.397 BLBplus -132.16, 169.96 65.72, 32.0 -78.17, 140.3 56.84, 82.43 67.0, 6.27 out-out out 13.544 Saltbr-out 14.732 HRD-in -69.71, -62.71 86.1, -12.85 out-out-none SNCoon out-none ActLoopNT-out 6.542 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 27.23 APE9-dihe-in -63.25, 122.03 APE8-dihe-in -75.98, 67.82 APE8-rot-na 29.66 APE67-dihe-in -76.37, -3.74 -56.38, -36.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.726 APE9-dist-in 7.987 T790M,V948R None None XRAY 2.1 0.191 0.226 A 328 299 14 0 0 12 [[712, 970]] 1.0 8fv3 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8FV4C P00533 702 1013 1210.0 ANP:1102 ATPlike Inactive DFGin 4.082 13.558 BLBplus -127.73, 168.23 73.07, 11.78 -61.24, 145.82 61.45, 98.91 81.41, -31.2 out-out out 13.742 Saltbr-out 16.115 HRD-in -67.13, -63.64 88.26, -13.01 out-out-out SNCooo out-out ActLoopNT-out 6.584 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -45.21, -49.43 APE9-dihe-in -74.91, 126.99 APE8-dihe-in -76.17, 58.7 APE8-rot-na 28.97 APE67-dihe-in -74.88, -4.9 -52.62, -40.92 APE12-dist-na 999.0 APE11-dist-na 16.262 APE10-dist-na 12.232 APE9-dist-out 8.1 T790M,V948R None None XRAY 2.2 0.204 0.261 C 328 296 11 0 0 11 [[712, 970]] 1.0 8fv4 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO3B P00533 702 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 3.657 14.934 BLBplus -134.55, 162.66 68.08, 49.36 -93.73, 164.43 101.15, 105.54 56.1, 2.84 out-out out 13.767 Saltbr-out 13.971 HRD-in -68.15, -46.1 73.95, -11.19 out-out-out SNCooo out-out ActLoopNT-out 6.842 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 106.24 APE8-dihe-in -74.12, 71.61 APE8-rot-na 27.49 APE67-dihe-in -65.2, -1.6 -53.66, -41.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.13 T790M,V948R None None XRAY 2.49 0.231 0.269 B 328 291 18 0 0 13 [[712, 970]] 1.0 8to3 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO4B P00533 702 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 4.321 13.838 BLBplus -145.22, 172.21 45.08, 44.37 -91.4, 153.78 67.05, 82.38 64.94, 7.17 out-out out 14.011 Saltbr-out 13.48 HRD-in -63.39, -70.27 96.97, -15.43 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.51 APE8-dihe-in -77.84, 67.96 APE8-rot-na 10.85 APE67-dihe-in -65.93, -24.75 -51.27, -47.41 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.537 T790M,V948R None None XRAY 2.99 0.176 0.231 B 328 290 18 0 0 14 [[712, 970]] 1.0 8to4 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4ZSED P00533 701 1015 1210.0 ANP:4001 ATPlike Inactive DFGin 4.481 13.699 BLBplus -139.61, 164.7 66.53, 26.19 -71.23, 138.48 53.66, 91.47 74.43, 7.23 out-out out 13.877 Saltbr-out 13.686 HRD-in -70.41, -53.51 80.03, -13.83 out-out-none SNCoon out-none ActLoopNT-out 6.522 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.0 APE8-dihe-in -83.67, 68.18 APE8-rot-na 28.71 APE67-dihe-in -64.05, -23.47 -60.9, -39.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.989 T790M,V948R None None XRAY 1.97 0.191 0.213 D 331 297 14 0 0 12 [[712, 970]] 1.0 4zse Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5D41B P00533 701 1014 1210.0 ANP:2001 ATPlike Inactive DFGin 3.946 14.283 BLBplus -122.59, 173.39 56.77, 40.3 -84.43, 150.38 61.52, 86.97 79.88, -36.14 out-out out 13.666 Saltbr-out 11.144 HRD-in -72.27, -56.38 80.95, -10.72 out-out-out SNCooo out-out ActLoopNT-out 6.673 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -30.97 APE9-dihe-in -100.3, 124.18 APE8-dihe-in -72.86, 61.7 APE8-rot-na 30.04 APE67-dihe-in -79.76, 0.67 -51.2, -39.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.501 APE9-dist-out 8.352 T790M,V948R None None XRAY 2.31 0.175 0.207 B 331 302 12 0 0 12 [[712, 970]] 1.0 5d41 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5X2AD P00533 701 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 4.567 13.491 BLBplus -132.47, 164.02 73.22, 18.47 -66.23, 142.03 48.39, 91.71 77.4, 1.26 out-out out 13.992 Saltbr-out 14.35 HRD-in -72.94, -56.49 82.37, -10.91 out-out-out SNCooo out-out ActLoopNT-out 6.463 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 3.06 APE9-dihe-in -69.62, 129.82 APE8-dihe-in -83.4, 65.28 APE8-rot-na 22.72 APE67-dihe-in -72.49, -3.02 -53.67, -40.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.897 APE9-dist-out 8.235 T790M,V948R None None XRAY 1.85 0.176 0.219 D 331 297 13 0 0 10 [[712, 970]] 1.0 5x2a Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXKB P00533 700 1007 1210.0 ANP:1101 ATPlike Inactive DFGin 4.788 14.304 BLBplus -133.99, 169.66 58.32, 39.23 -93.88, 160.42 49.41, 87.38 74.89, 999.0 out-out out 13.49 Saltbr-out 12.394 HRD-in -66.37, -58.14 81.2, -5.32 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.52 APE8-dihe-in -80.54, 72.01 APE8-rot-na 30.24 APE67-dihe-in -73.85, -4.26 -53.45, -45.93 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.541 T790M,V948R None None XRAY 3.1 0.223 0.261 B 331 290 18 0 0 18 [[712, 970]] 1.0 7jxk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXMC P00533 702 1006 1210.0 ANP:1101 ATPlike Inactive DFGin 4.283 13.994 BLBplus -133.09, 168.24 59.36, 33.1 -80.78, 143.72 58.15, 87.09 66.36, 74.02 out-out out 13.963 Saltbr-out 13.118 HRD-in -67.9, -61.75 83.53, -6.82 out-out-none SNCoon out-none ActLoopNT-out 9.008 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.47 APE8-dihe-in -77.6, 66.96 APE8-rot-na 35.92 APE67-dihe-in -75.2, -5.27 -47.14, -42.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.517 T790M,V948R None None XRAY 2.192 0.228 0.271 C 331 285 20 0 0 15 [[712, 970]] 1.0 7jxm Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CNOB P00533 698 1015 1210.0 ANP:61001 ATPlike Inactive DFGin 3.889 14.151 BLBplus -128.77, 161.65 68.19, 38.17 -78.09, 143.32 56.13, 92.23 54.89, 36.11 out-out out 13.877 Saltbr-out 12.607 HRD-in -79.53, -48.18 74.57, -9.86 out-out-out SNCooo out-out ActLoopNT-out 8.188 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 114.62 APE9-dihe-in -83.89, 124.6 APE8-dihe-in -81.17, 61.86 APE8-rot-na 30.73 APE67-dihe-in -73.98, -7.26 -47.13, -40.74 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.092 APE9-dist-out 8.401 V948R None None XRAY 1.55 0.176 0.203 B 330 302 16 0 0 12 [[712, 970]] 1.0 5cno Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CNNA P00533 699 1014 1210.0 ANP:61101 ATPlike Inactive DFGin 3.97 14.17 BLBplus -125.09, 165.12 65.79, 30.65 -73.26, 142.49 57.23, 92.2 61.04, 28.88 out-out out 14.419 Saltbr-out 11.397 HRD-in -77.1, -52.71 74.61, -9.55 out-out-none SNCoon out-none ActLoopNT-out 8.169 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 61.56 APE9-dihe-in -85.48, 136.67 APE8-dihe-in -75.32, 67.13 APE8-rot-na 28.89 APE67-dihe-in -79.02, -2.66 -49.07, -38.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.997 APE9-dist-in 7.994 I706Q None None XRAY 1.9 0.183 0.211 A 350 300 16 0 0 13 [[712, 970]] 1.0 5cnn Homo sapiens TYR_EGFR_HUMAN TYR 1.3e-87 299.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1DB P00533 702 1013 1210.0 ANP:1101,NQ1:1102 ATPlike,Type3 Inactive DFGin 4.737 14.03 BLBplus -133.29, 171.5 64.7, 17.77 -68.3, 145.06 52.12, 92.58 81.65, -14.38 out-out out 13.79 Saltbr-out 14.416 HRD-in -75.11, -58.04 81.02, -12.96 out-out-out SNCooo out-out ActLoopNT-out 6.39 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -53.71 APE8-dihe-in -78.39, 61.97 APE8-rot-na 34.06 APE67-dihe-in -73.46, -6.67 -54.96, -43.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.356 None None None XRAY 2.4 0.195 0.213 B 327 300 12 0 0 12 [[712, 970]] 1.0 6p1d Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1LA P00533 701 1007 1210.0 ANP:1102,9LL:1103 ATPlike,Type3 Inactive DFGin 5.09 14.609 BLBplus -137.99, 174.26 51.86, 38.49 -97.68, 160.33 56.12, 79.32 80.95, 13.49 out-out out 13.09 Saltbr-out 11.075 HRD-in -66.81, -53.87 69.64, 3.15 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.91 APE8-dihe-in -92.34, 76.37 APE8-rot-na 35.99 APE67-dihe-in -76.25, -4.78 -68.05, -35.38 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.361 T790M,V948R None None XRAY 2.8 0.203 0.237 A 327 288 19 0 0 17 [[712, 970]] 1.0 6p1l Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1LC P00533 702 1005 1210.0 ANP:1102,9LL:1103 ATPlike,Type3 Inactive DFGin 4.947 14.346 BLBplus -138.12, 175.57 52.19, 39.44 -97.35, 162.11 56.76, 79.57 81.63, 13.51 out-out out 13.069 Saltbr-out 12.69 HRD-in -65.46, -53.47 68.76, 3.35 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -21.1 APE8-dihe-in -91.14, 76.85 APE8-rot-na 36.16 APE67-dihe-in -74.42, -4.16 -69.53, -34.23 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.035 T790M,V948R None None XRAY 2.8 0.203 0.237 C 327 280 24 0 0 17 [[712, 970]] 1.0 6p1l Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1LD P00533 702 1015 1210.0 ANP:1102,9LL:1103 ATPlike,Type3 Inactive DFGin 5.193 14.634 BLBplus -136.45, 175.46 51.75, 39.49 -96.95, 158.96 56.24, 81.53 81.72, 11.0 out-out out 13.155 Saltbr-out 10.982 HRD-in -66.43, -53.42 65.79, 5.44 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.86 APE8-dihe-in -92.75, 77.55 APE8-rot-na 35.81 APE67-dihe-in -75.19, -4.23 -67.58, -35.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.094 T790M,V948R None None XRAY 2.8 0.203 0.237 D 327 296 17 0 0 17 [[712, 970]] 1.0 6p1l Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P8QA P00533 699 1019 1210.0 ANP:2001,O57:2002 ATPlike,Type3 Inactive DFGin 5.291 14.467 BLBplus -136.39, 166.39 65.62, 19.67 -68.64, 141.86 47.45, 96.29 88.91, -15.41 out-out out 13.793 Saltbr-out 13.394 HRD-in -77.48, -60.3 86.7, -15.68 out-out-none SNCoon out-none ActLoopNT-out 6.927 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 121.69 APE8-dihe-in -82.28, 70.48 APE8-rot-na 31.78 APE67-dihe-in -69.54, -10.7 -59.7, -40.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.523 T790M,V948R None None XRAY 1.9 0.169 0.195 A 327 309 12 0 0 12 [[712, 970]] 1.0 6p8q Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6XL4D P00533 700 1013 1210.0 ANP:1102,NQ1:1103 ATPlike,Type3 Inactive DFGin 4.89 14.247 BLBplus -133.2, 175.82 65.76, 18.85 -77.15, 145.6 52.8, 92.59 74.56, -2.19 out-out out 13.624 Saltbr-out 15.83 HRD-in -71.69, -57.79 76.59, -4.88 out-out-none SNCoon out-none ActLoopNT-out 6.478 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.17 APE8-dihe-in -78.79, 71.74 APE8-rot-na 31.74 APE67-dihe-in -74.38, -1.99 -55.71, -41.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.77 T790M,V948R None None XRAY 2.06 0.216 0.252 D 328 300 14 0 0 11 [[712, 970]] 1.0 6xl4 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO4C P00533 702 1013 1210.0 ANP:1102,IXR:1103 ATPlike,Type3 Inactive DFGin 5.324 14.703 BLBplus -141.27, 171.12 64.77, 53.38 -109.59, 167.64 42.74, 100.72 59.4, 999.0 out-out out 13.294 Saltbr-out 12.35 HRD-in -63.29, -59.94 84.01, 4.45 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 130.05 APE8-dihe-in -90.09, 61.93 APE8-rot-na 21.85 APE67-dihe-in -81.47, -6.07 -53.96, -24.6 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.836 T790M,V948R None None XRAY 2.99 0.176 0.231 C 328 289 18 0 0 18 [[712, 970]] 1.0 8to4 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO4D P00533 702 1005 1210.0 ANP:1102,IXR:1103 ATPlike,Type3 Inactive DFGin 4.551 14.188 BLBplus -127.27, 157.13 78.08, 44.22 -85.23, -172.29 38.08, 100.01 106.69, 999.0 out-out out 13.656 Saltbr-out 10.825 HRD-in -72.87, -44.75 69.45, -7.84 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 105.73 APE8-dihe-in -81.92, 60.79 APE8-rot-na 34.7 APE67-dihe-in -66.67, -11.33 -39.66, -48.35 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.66 T790M,V948R None None XRAY 2.99 0.176 0.231 D 328 283 20 0 0 18 [[712, 970]] 1.0 8to4 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5D41A P00533 698 1014 1210.0 ANP:1102,57N:1103 ATPlike,Type3 Inactive DFGin 4.968 14.448 BLBplus -130.27, 169.23 61.95, 37.88 -93.29, 173.71 50.74, 86.35 79.65, -10.55 out-out out 12.815 Saltbr-out 11.374 HRD-in -77.25, -55.76 78.51, -14.31 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 155.57 APE8-dihe-in -80.12, 74.82 APE8-rot-na 31.53 APE67-dihe-in -75.45, -3.11 -51.46, -43.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8 T790M,V948R None None XRAY 2.31 0.175 0.207 A 331 300 17 0 0 17 [[712, 970]] 1.0 5d41 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6DUKA P00533 701 1006 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.416 14.801 BLBplus -133.89, 165.03 66.94, 37.08 -93.36, 166.29 58.42, 86.37 91.91, 6.11 out-out out 13.918 Saltbr-out 14.179 HRD-in -76.73, -64.87 85.37, -18.97 out-out-out SNCooo out-out ActLoopNT-out 7.438 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.39, -10.84 APE9-dihe-in -125.5, 116.79 APE8-dihe-in -80.16, 76.04 APE8-rot-na 31.69 APE67-dihe-in -76.14, -1.34 -58.18, -44.83 APE12-dist-na 17.364 APE11-dist-na 15.202 APE10-dist-na 11.776 APE9-dist-in 7.311 T790M,V948R None None XRAY 2.2 0.191 0.223 A 331 306 0 0 0 0 [[712, 970]] 1.0 6duk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6DUKB P00533 699 1007 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.681 14.65 BLBplus -136.44, 165.42 61.83, 36.22 -89.54, 161.73 53.44, 89.67 90.48, 19.39 out-out out 13.812 Saltbr-out 14.733 HRD-in -68.48, -61.78 82.94, -15.18 out-out-none SNCoon out-none ActLoopNT-out 7.292 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 128.53 APE8-dihe-in -76.17, 63.91 APE8-rot-na 26.99 APE67-dihe-in -79.83, -2.27 -51.77, -41.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.922 T790M,V948R None None XRAY 2.2 0.191 0.223 B 331 296 13 0 0 13 [[712, 970]] 1.0 6duk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6DUKC P00533 699 1007 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.661 14.391 BLBplus -137.36, 170.05 61.14, 32.95 -87.42, 165.36 52.89, 84.68 86.51, 15.0 out-out out 13.749 Saltbr-out 12.387 HRD-in -66.04, -61.2 80.35, -9.27 out-out-none SNCoon out-none ActLoopNT-out 8.286 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 116.92 APE8-dihe-in -77.64, 67.39 APE8-rot-na 32.93 APE67-dihe-in -71.69, -8.16 -55.72, -42.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.823 T790M,V948R None None XRAY 2.2 0.191 0.223 C 331 295 14 0 0 14 [[712, 970]] 1.0 6duk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6DUKD P00533 701 1007 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.605 14.634 BLBplus -137.83, 165.45 65.63, 29.61 -82.3, 167.28 56.12, 84.13 94.16, 13.47 out-out out 14.053 Saltbr-out 14.886 HRD-in -74.03, -57.71 81.46, -18.53 out-out-out SNCooo out-out ActLoopNT-out 7.321 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -76.03, 11.31 APE9-dihe-in -134.89, 121.24 APE8-dihe-in -86.59, 77.19 APE8-rot-na 34.21 APE67-dihe-in -72.84, -7.51 -59.65, -43.13 APE12-dist-na 17.747 APE11-dist-na 15.555 APE10-dist-na 11.903 APE9-dist-in 7.539 T790M,V948R None None XRAY 2.2 0.191 0.223 D 331 307 0 0 0 0 [[712, 970]] 1.0 6duk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6DUKE P00533 698 1007 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.706 14.387 BLBplus -132.31, 167.27 63.11, 42.82 -102.17, 159.55 52.62, 85.09 88.84, 16.78 out-out out 13.768 Saltbr-out 14.361 HRD-in -70.33, -59.21 85.76, -23.74 out-out-none SNCoon out-none ActLoopNT-out 7.686 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 1.83 APE9-dihe-in -127.74, 112.92 APE8-dihe-in -68.38, 64.27 APE8-rot-na 21.48 APE67-dihe-in -73.72, -8.33 -52.7, -41.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.291 APE9-dist-in 7.941 T790M,V948R None None XRAY 2.2 0.191 0.223 E 331 298 12 0 0 12 [[712, 970]] 1.0 6duk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6DUKF P00533 701 1009 1210.0 ANP:1102,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.653 14.612 BLBplus -133.82, 164.75 63.96, 32.85 -83.32, 163.7 53.83, 93.49 88.31, 19.42 out-out out 14.108 Saltbr-out 15.144 HRD-in -67.38, -62.37 88.35, -19.9 out-out-none SNCoon out-none ActLoopNT-out 7.319 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 115.72 APE8-dihe-in -80.72, 70.63 APE8-rot-na 32.98 APE67-dihe-in -75.6, -2.87 -62.49, -36.24 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.841 T790M,V948R None None XRAY 2.2 0.191 0.223 F 331 298 11 0 0 11 [[712, 970]] 1.0 6duk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXKD P00533 700 1007 1210.0 ANP:1101,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.861 14.45 BLBplus -134.29, 170.65 60.11, 37.92 -95.07, 160.21 48.8, 86.41 74.63, 26.88 out-out out 13.457 Saltbr-out 11.763 HRD-in -66.46, -59.56 80.54, -6.1 out-out-none SNCoon out-none ActLoopNT-out 8.903 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.41 APE8-dihe-in -81.29, 71.57 APE8-rot-na 30.4 APE67-dihe-in -73.66, -4.05 -53.54, -44.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.472 T790M,V948R None None XRAY 3.1 0.223 0.261 D 331 294 14 0 0 14 [[712, 970]] 1.0 7jxk Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXMD P00533 700 1007 1210.0 ANP:1101,9LL:1103 ATPlike,Type3 Inactive DFGin 4.952 14.337 BLBplus -135.28, 170.25 61.86, 31.57 -85.27, 155.14 53.77, 85.22 78.23, 19.31 out-out out 13.049 Saltbr-out 11.894 HRD-in -66.52, -63.02 84.71, -6.37 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.04 APE8-dihe-in -80.42, 66.88 APE8-rot-na 32.97 APE67-dihe-in -76.05, -3.45 -51.47, -42.13 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.762 T790M,V948R None None XRAY 2.192 0.228 0.271 D 331 291 17 0 0 17 [[712, 970]] 1.0 7jxm Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXPA P00533 700 1007 1210.0 ANP:1101,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.747 14.617 BLBplus -136.18, 166.76 64.66, 34.04 -92.53, 168.9 56.02, 85.41 85.63, 11.86 out-out out 13.988 Saltbr-out 14.307 HRD-in -74.54, -64.28 89.28, -17.63 out-out-out SNCooo out-out ActLoopNT-out 7.509 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -97.63, -15.8 APE9-dihe-in -113.05, 126.54 APE8-dihe-in -83.29, 68.9 APE8-rot-na 33.94 APE67-dihe-in -74.36, -3.96 -52.3, -47.62 APE12-dist-na 17.096 APE11-dist-na 14.956 APE10-dist-na 11.693 APE9-dist-in 7.406 T790M,V948R None None XRAY 2.16 0.214 0.247 A 331 308 0 0 0 0 [[712, 970]] 1.0 7jxp Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXPB P00533 700 1007 1210.0 ANP:1101,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.671 14.511 BLBplus -135.21, 165.17 64.35, 37.85 -90.15, 169.17 53.82, 91.67 84.59, 7.68 out-out out 13.756 Saltbr-out 13.888 HRD-in -70.65, -63.17 87.36, -17.28 out-out-out SNCooo out-out ActLoopNT-out 7.592 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -97.44, -17.16 APE9-dihe-in -126.66, 129.43 APE8-dihe-in -78.52, 67.74 APE8-rot-na 34.72 APE67-dihe-in -76.32, -3.64 -51.52, -45.13 APE12-dist-na 17.438 APE11-dist-na 15.214 APE10-dist-na 12.275 APE9-dist-in 7.617 T790M,V948R None None XRAY 2.16 0.214 0.247 B 331 308 0 0 0 0 [[712, 970]] 1.0 7jxp Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXPD P00533 700 1007 1210.0 ANP:1101,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.766 14.661 BLBplus -135.69, 167.35 65.6, 33.96 -89.97, 168.72 55.6, 87.2 84.96, 9.82 out-out out 13.526 Saltbr-out 11.283 HRD-in -71.06, -65.03 87.13, -14.24 out-out-none SNCoon out-none ActLoopNT-out 8.004 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.01 APE8-dihe-in -77.89, 69.26 APE8-rot-na 33.29 APE67-dihe-in -74.9, -2.69 -52.27, -42.76 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.744 T790M,V948R None None XRAY 2.16 0.214 0.247 D 331 294 14 0 0 14 [[712, 970]] 1.0 7jxp Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXPF P00533 700 1007 1210.0 ANP:1101,JBJ:1103 ATPlike,Type3 Inactive DFGin 4.974 14.702 BLBplus -136.82, 166.82 61.14, 36.57 -93.57, 171.83 53.4, 92.66 83.03, -0.51 out-out out 13.674 Saltbr-out 11.57 HRD-in -71.01, -63.71 87.17, -13.68 out-out-none SNCoon out-none ActLoopNT-out 9.118 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.33 APE8-dihe-in -78.62, 69.48 APE8-rot-na 32.72 APE67-dihe-in -72.69, -4.28 -52.16, -45.07 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.621 T790M,V948R None None XRAY 2.16 0.214 0.247 F 331 294 14 0 0 14 [[712, 970]] 1.0 7jxp Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXQB P00533 701 1007 1210.0 ANP:1102,VNS:1103 ATPlike,Type3 Inactive DFGin 4.915 14.438 BLBplus -136.8, 171.78 58.87, 35.86 -91.33, 162.29 51.51, 87.21 80.67, 16.0 out-out out 13.335 Saltbr-out 12.698 HRD-in -67.21, -58.71 77.88, -12.51 out-out-none SNCoon out-none ActLoopNT-out 8.896 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -177.71 APE9-dihe-in -105.47, 135.84 APE8-dihe-in -83.2, 67.78 APE8-rot-na 33.37 APE67-dihe-in -74.22, -7.65 -49.73, -41.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.734 APE9-dist-in 7.645 T790M,V948R None None XRAY 1.83 0.185 0.218 B 331 297 10 0 0 10 [[712, 970]] 1.0 7jxq Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXQD P00533 700 1007 1210.0 ANP:1102,VNS:1103 ATPlike,Type3 Inactive DFGin 4.844 14.328 BLBplus -136.14, 172.56 58.98, 36.18 -92.84, 162.13 51.55, 88.05 79.36, 17.26 out-out out 13.42 Saltbr-out 11.89 HRD-in -65.12, -58.0 78.92, -12.53 out-out-none SNCoon out-none ActLoopNT-out 8.94 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.09 APE8-dihe-in -80.19, 68.24 APE8-rot-na 33.29 APE67-dihe-in -74.77, -5.19 -50.69, -44.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.579 T790M,V948R None None XRAY 1.83 0.185 0.218 D 331 298 10 0 0 10 [[712, 970]] 1.0 7jxq Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7LTXA P00533 700 1007 1210.0 ANP:1101,YFA:1103 ATPlike,Type3 Inactive DFGin 5.248 14.564 BLBplus -135.35, 163.04 64.03, 33.94 -82.37, 179.4 48.16, 87.26 -162.42, -162.89 out-out out 13.182 Saltbr-out 10.599 HRD-in -67.02, -61.48 82.46, -5.8 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.93 APE8-dihe-in -80.94, 68.72 APE8-rot-na 31.43 APE67-dihe-in -70.18, -9.53 -51.9, -44.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.02 T790M,V948R None None XRAY 2.3 0.187 0.216 A 331 292 16 0 0 16 [[712, 970]] 1.0 7ltx Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7LTXB P00533 700 1007 1210.0 ANP:1101,YFA:1103 ATPlike,Type3 Inactive DFGin 5.197 14.495 BLBplus -136.17, 169.66 62.42, 34.77 -78.22, 170.05 42.44, 90.17 -152.16, -165.64 out-out out 13.123 Saltbr-out 10.226 HRD-in -65.63, -61.11 82.51, -6.05 out-out-none SNCoon out-none ActLoopNT-out 9.239 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 125.13 APE8-dihe-in -82.01, 66.41 APE8-rot-na 31.46 APE67-dihe-in -73.58, -7.26 -49.71, -42.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.829 T790M,V948R None None XRAY 2.3 0.187 0.216 B 331 293 15 0 0 15 [[712, 970]] 1.0 7ltx Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7LTXC P00533 700 1007 1210.0 ANP:1101,YFA:1103 ATPlike,Type3 Inactive DFGin 5.123 14.511 BLBplus -136.55, 165.71 63.6, 32.17 -87.45, 156.27 46.73, 94.27 148.1, 156.05 out-out out 13.071 Saltbr-out 10.076 HRD-in -65.09, -59.89 81.29, -6.26 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.8 APE8-dihe-in -79.63, 67.92 APE8-rot-na 31.3 APE67-dihe-in -72.94, -5.81 -52.93, -44.7 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.864 T790M,V948R None None XRAY 2.3 0.187 0.216 C 331 292 16 0 0 16 [[712, 970]] 1.0 7ltx Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7LTXD P00533 700 1007 1210.0 ANP:1101,YFA:1103 ATPlike,Type3 Inactive DFGin 5.346 14.443 BLBplus -137.08, 165.99 63.56, 34.05 -81.77, 167.16 44.82, 94.68 -177.57, 165.83 out-out out 12.986 Saltbr-out 10.34 HRD-in -68.33, -62.57 83.39, -4.99 out-out-none SNCoon out-none ActLoopNT-out 9.494 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.9 APE8-dihe-in -80.86, 67.56 APE8-rot-na 30.12 APE67-dihe-in -73.23, -5.97 -50.49, -42.58 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.917 T790M,V948R None None XRAY 2.3 0.187 0.216 D 331 293 15 0 0 15 [[712, 970]] 1.0 7ltx Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8GB4A P00533 700 1007 1210.0 ANP:1102,YW5:1103 ATPlike,Type3 Inactive DFGin 4.738 14.778 BLBplus -140.96, 174.92 57.37, 44.23 -99.53, 158.98 50.67, 86.24 74.62, 16.37 out-out out 13.355 Saltbr-out 11.698 HRD-in -69.91, -59.18 79.33, -9.52 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.01 APE8-dihe-in -76.27, 67.14 APE8-rot-na 30.24 APE67-dihe-in -75.65, -5.48 -58.37, -41.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.058 T790M,V948R None None XRAY 2.59 0.23 0.254 A 331 292 16 0 0 16 [[712, 970]] 1.0 8gb4 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8GB4B P00533 700 1007 1210.0 ANP:1102,YW5:1103 ATPlike,Type3 Inactive DFGin 4.858 14.681 BLBplus -140.61, 174.15 57.09, 43.59 -100.33, 162.57 51.99, 86.76 77.41, 18.84 out-out out 13.39 Saltbr-out 10.531 HRD-in -69.24, -58.17 79.24, -10.08 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.16 APE8-rot-na 30.06 APE67-dihe-in -75.09, -5.85 -58.81, -39.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,V948R None None XRAY 2.59 0.23 0.254 B 331 290 18 0 0 18 [[712, 970]] 1.0 8gb4 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8GB4C P00533 700 1012 1210.0 ANP:1102,YW5:1103 ATPlike,Type3 Inactive DFGin 4.732 14.602 BLBplus -141.16, 174.43 57.44, 44.8 -99.46, 158.79 49.11, 85.48 74.36, 22.53 out-out out 13.185 Saltbr-out 11.537 HRD-in -70.07, -59.0 77.64, -8.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 127.65 APE8-dihe-in -76.99, 66.94 APE8-rot-na 30.24 APE67-dihe-in -75.42, -5.6 -59.05, -41.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.014 T790M,V948R None None XRAY 2.59 0.23 0.254 C 331 297 16 0 0 16 [[712, 970]] 1.0 8gb4 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8GB4D P00533 700 1007 1210.0 ANP:1102,YW5:1103 ATPlike,Type3 Inactive DFGin 4.686 14.698 BLBplus -141.21, 175.0 57.29, 43.49 -99.79, 159.92 51.61, 87.18 76.57, 22.15 out-out out 13.561 Saltbr-out 10.91 HRD-in -69.19, -58.43 79.07, -10.45 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 65.97 APE8-rot-na 30.21 APE67-dihe-in -74.96, -5.48 -59.31, -40.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 T790M,V948R None None XRAY 2.59 0.23 0.254 D 331 291 17 0 0 17 [[712, 970]] 1.0 8gb4 Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7K1IA P00533 700 1007 1210.0 ANP:1102,VNS:1103 ATPlike,Type3 Inactive DFGin 4.837 14.412 BLBplus -124.92, 173.52 55.34, 38.4 -93.27, 168.4 51.69, 86.03 70.99, 11.24 out-out out 13.596 Saltbr-out 12.212 HRD-in -68.02, -55.76 76.66, -7.58 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 142.86 APE8-dihe-in -84.0, 73.03 APE8-rot-na 29.2 APE67-dihe-in -72.27, -9.54 -58.41, -42.03 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.42 L858R,V948R None None XRAY 3.202 0.266 0.311 A 331 288 20 0 0 17 [[712, 970]] 1.0 7k1i Homo sapiens TYR_EGFR_HUMAN TYR 8.5e-87 296.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1DC P00533 702 1006 1210.0 NQ1:1101,ANP:1102 Type3,ATPlike Inactive DFGin 5.383 14.459 BLBplus -142.0, 171.97 66.8, 29.01 -86.08, 152.7 44.82, 92.23 73.36, -11.9 out-out out 13.614 Saltbr-out 13.736 HRD-in -69.23, -60.69 76.65, -2.9 out-out-none SNCoon out-none ActLoopNT-out 6.785 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 96.45 APE8-dihe-in -76.51, 79.09 APE8-rot-na 31.04 APE67-dihe-in -75.49, -1.74 -58.74, -40.16 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.258 None None None XRAY 2.4 0.195 0.213 C 327 292 13 0 0 13 [[712, 970]] 1.0 6p1d Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1DD P00533 701 1008 1210.0 NQ1:1101,ANP:1102 Type3,ATPlike Inactive DFGin 4.796 14.102 BLBplus -132.01, 171.13 65.01, 17.93 -68.87, 143.86 51.94, 90.04 79.55, -15.22 out-out out 13.622 Saltbr-out 13.734 HRD-in -75.21, -58.43 80.83, -11.58 out-out-none SNCoon out-none ActLoopNT-out 6.633 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 114.5 APE8-dihe-in -78.23, 70.43 APE8-rot-na 33.16 APE67-dihe-in -74.16, -5.23 -50.48, -45.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.251 None None None XRAY 2.4 0.195 0.213 D 327 295 13 0 0 13 [[712, 970]] 1.0 6p1d Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXQA P00533 700 1007 1210.0 VNS:1102,ANP:1103 Type3,ATPlike Inactive DFGin 4.86 14.542 BLBplus -136.59, 171.99 58.78, 36.07 -93.08, 163.3 53.5, 85.99 81.0, 16.2 out-out out 13.6 Saltbr-out 11.402 HRD-in -66.89, -59.97 80.26, -12.87 out-out-out SNCooo out-out ActLoopNT-out 8.834 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 0.37 APE9-dihe-in -62.95, 136.95 APE8-dihe-in -80.94, 64.03 APE8-rot-na 32.82 APE67-dihe-in -75.31, -4.79 -52.17, -43.0 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.411 APE9-dist-out 8.21 T790M,V948R None None XRAY 1.83 0.185 0.218 A 331 296 12 0 0 12 [[712, 970]] 1.0 7jxq Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXQC P00533 700 1007 1210.0 VNS:1102,ANP:1103 Type3,ATPlike Inactive DFGin 4.785 14.453 BLBplus -135.56, 173.47 59.34, 36.33 -94.04, 161.61 52.57, 85.94 80.36, 16.26 out-out out 13.527 Saltbr-out 12.033 HRD-in -65.88, -57.49 78.82, -12.32 out-out-none SNCoon out-none ActLoopNT-out 8.819 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.15 APE8-dihe-in -80.46, 67.52 APE8-rot-na 31.26 APE67-dihe-in -73.66, -6.11 -51.25, -43.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.434 T790M,V948R None None XRAY 1.83 0.185 0.218 C 331 298 10 0 0 10 [[712, 970]] 1.0 7jxq Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6P1DA P00533 700 1021 1210.0 ANP:1101 ATPlike Inactive DFGin 5.301 16.437 BLBtrans -129.26, 172.58 65.52, 23.29 -64.33, 142.93 151.16, 79.23 78.73, -15.31 out-out out 13.52 Saltbr-out 12.421 HRD-in -76.98, -57.73 83.77, -12.82 out-out-none SNCoon out-none ActLoopNT-out 7.141 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 149.92 APE9-dihe-in -115.71, 137.77 APE8-dihe-in -79.58, 71.21 APE8-rot-na 32.94 APE67-dihe-in -73.74, -5.13 -51.22, -45.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.184 APE9-dist-in 7.677 None None None XRAY 2.4 0.195 0.213 A 327 309 13 0 0 13 [[712, 970]] 1.0 6p1d Homo sapiens TYR_EGFR_HUMAN TYR 6e-88 300.6 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6WAKB P00533 701 1020 1210.0 ANP:1101 ATPlike Inactive DFGin 5.177 16.231 BLBtrans -117.23, 173.55 69.28, 15.65 -59.01, 135.6 148.98, 94.52 90.59, -20.79 out-out out 13.949 Saltbr-out 13.543 HRD-in -74.15, -58.44 85.37, -10.97 out-out-none SNCoon out-none ActLoopNT-out 6.481 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -3.86 APE9-dihe-in -108.7, 124.16 APE8-dihe-in -81.26, 64.66 APE8-rot-na 31.83 APE67-dihe-in -71.85, -2.7 -48.1, -51.02 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.366 APE9-dist-in 7.826 T790M,V948R None None XRAY 2.4 0.219 0.23 B 328 316 4 0 0 4 [[712, 970]] 1.0 6wak Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 6WXNB P00533 701 1021 1210.0 ANP:1101 ATPlike Inactive DFGin 5.283 16.295 BLBtrans -123.51, 174.07 66.96, 19.19 -61.23, 137.15 158.07, 75.44 91.96, -18.66 out-out out 13.565 Saltbr-out 13.523 HRD-in -75.09, -55.39 80.46, -8.33 out-out-none SNCoon out-none ActLoopNT-out 6.48 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -21.86 APE9-dihe-in -115.99, 110.82 APE8-dihe-in -78.55, 77.75 APE8-rot-na 31.2 APE67-dihe-in -73.85, -5.28 -56.42, -42.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.825 APE9-dist-in 7.844 T790M,V948R None None XRAY 1.76 0.209 0.235 B 328 303 11 0 0 11 [[712, 970]] 1.0 6wxn Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8FV3B P00533 701 1021 1210.0 ANP:1102 ATPlike Inactive DFGin 5.439 16.496 BLBtrans -118.64, 177.37 63.4, 20.55 -58.75, 145.81 159.38, 77.34 77.7, -11.94 out-out out 13.907 Saltbr-out 12.609 HRD-in -79.27, -57.12 85.07, -16.18 out-out-none SNCoon out-none ActLoopNT-out 6.551 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -85.47 APE9-dihe-in -94.5, 111.51 APE8-dihe-in -78.45, 79.51 APE8-rot-na 26.67 APE67-dihe-in -72.96, -7.53 -57.83, -45.1 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.158 APE9-dist-in 7.609 T790M,V948R None None XRAY 2.1 0.191 0.226 B 328 307 12 0 0 12 [[712, 970]] 1.0 8fv3 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8FV3D P00533 701 1008 1210.0 ANP:1102 ATPlike Inactive DFGin 5.123 16.069 BLBtrans -118.91, 178.66 63.22, 20.1 -58.76, 136.59 151.59, 72.8 86.53, -14.56 out-out out 13.636 Saltbr-out 11.878 HRD-in -77.73, -54.76 83.51, -15.49 out-out-none SNCoon out-none ActLoopNT-out 6.686 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -35.35 APE9-dihe-in -75.26, 139.37 APE8-dihe-in -77.41, 75.08 APE8-rot-na 30.35 APE67-dihe-in -77.52, -1.37 -56.44, -41.73 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 12.989 APE9-dist-in 7.856 T790M,V948R None None XRAY 2.1 0.191 0.226 D 328 295 13 0 0 12 [[712, 970]] 1.0 8fv3 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8FV4A P00533 701 1013 1210.0 ANP:1102 ATPlike Inactive DFGin 5.115 16.083 BLBtrans -131.04, 178.71 63.39, 21.89 -65.77, 133.12 153.56, 67.25 81.77, -5.74 out-out out 13.965 Saltbr-out 14.366 HRD-in -75.29, -65.35 93.54, -10.41 out-out-out SNCooo out-out ActLoopNT-out 6.614 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.22 APE8-dihe-in -79.99, 70.44 APE8-rot-na 34.65 APE67-dihe-in -69.8, 5.09 -60.12, -39.98 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.027 T790M,V948R None None XRAY 2.2 0.204 0.261 A 328 298 15 0 0 13 [[712, 970]] 1.0 8fv4 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO3C P00533 702 1014 1210.0 ANP:1102 ATPlike Inactive DFGin 5.753 16.533 BLBtrans -133.38, -174.65 59.98, 24.74 -65.74, 136.64 157.32, 80.88 79.44, -13.7 out-out out 13.655 Saltbr-out 13.531 HRD-in -66.43, -56.05 80.37, -11.56 out-out-out SNCooo out-out ActLoopNT-out 6.373 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.97 APE8-dihe-in -84.11, 59.51 APE8-rot-na 29.31 APE67-dihe-in -74.18, -0.3 -51.78, -42.05 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.174 T790M,V948R None None XRAY 2.49 0.231 0.269 C 328 295 16 0 0 13 [[712, 970]] 1.0 8to3 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO3D P00533 702 1008 1210.0 ANP:1102 ATPlike Inactive DFGin 6.266 16.712 BLBtrans -127.69, 172.31 68.6, 30.15 -69.25, 140.14 165.75, 69.84 67.25, -4.22 out-out out 14.386 Saltbr-out 13.199 HRD-in -68.61, -53.44 82.24, -15.94 out-out-out SNCooo out-out ActLoopNT-out 6.552 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 120.24 APE8-dihe-in -79.84, 75.73 APE8-rot-na 31.27 APE67-dihe-in -78.58, -0.75 -60.94, -39.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.144 T790M,V948R None None XRAY 2.49 0.231 0.269 D 328 293 14 0 0 13 [[712, 970]] 1.0 8to3 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 8TO4A P00533 701 1021 1210.0 ANP:1102 ATPlike Inactive DFGin 5.629 16.547 BLBtrans -124.14, -173.94 46.92, 31.67 -57.81, 155.21 158.64, 67.25 48.87, 11.58 out-out out 13.96 Saltbr-out 13.561 HRD-in -72.61, -58.43 93.96, -37.09 out-out-none SNCoon out-none ActLoopNT-out 6.932 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 82.65 APE8-dihe-in -66.65, 104.87 APE8-rot-na 26.84 APE67-dihe-in -69.56, -10.93 -75.01, -49.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.724 T790M,V948R None None XRAY 2.99 0.176 0.231 A 328 300 16 0 0 13 [[712, 970]] 1.0 8to4 Homo sapiens TYR_EGFR_HUMAN TYR 6.1e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4ZSEA P00533 699 1007 1210.0 ANP:1101 ATPlike Inactive DFGin 5.335 16.18 BLBtrans -132.89, 171.35 59.18, 30.95 -64.3, 136.47 153.66, 69.99 84.54, -7.18 out-out out 13.41 Saltbr-out 12.542 HRD-in -69.44, -53.13 80.36, -12.32 out-out-none SNCoon out-none ActLoopNT-out 6.5 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 151.84 APE9-dihe-in -73.75, 154.61 APE8-dihe-in -84.04, 78.01 APE8-rot-na 31.44 APE67-dihe-in -73.82, -9.83 -53.67, -42.49 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.754 APE9-dist-in 7.631 T790M,V948R None None XRAY 1.97 0.191 0.213 A 331 297 12 0 0 12 [[712, 970]] 1.0 4zse Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4ZSEB P00533 698 1022 1210.0 ANP:2001 ATPlike Inactive DFGin 5.443 16.534 BLBtrans -132.18, 168.84 69.74, 21.23 -63.33, 134.02 158.02, 77.95 88.87, -12.59 out-out out 13.594 Saltbr-out 12.729 HRD-in -70.54, -56.98 84.69, -9.62 out-out-none SNCoon out-none ActLoopNT-out 6.279 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -169.23 APE9-dihe-in -113.21, 138.46 APE8-dihe-in -83.6, 77.16 APE8-rot-na 29.29 APE67-dihe-in -64.08, -26.4 -59.09, -39.81 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.095 APE9-dist-in 7.664 T790M,V948R None None XRAY 1.97 0.191 0.213 B 331 313 12 0 0 12 [[712, 970]] 1.0 4zse Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4ZSEC P00533 700 1013 1210.0 ANP:3001 ATPlike Inactive DFGin 5.527 16.551 BLBtrans -132.06, 169.7 72.1, 15.79 -57.63, 131.91 161.52, 79.23 90.56, -14.81 out-out out 13.464 Saltbr-out 12.84 HRD-in -70.03, -52.52 81.38, -14.98 out-out-none SNCoon out-none ActLoopNT-out 6.218 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 117.83 APE8-dihe-in -83.98, 70.07 APE8-rot-na 31.43 APE67-dihe-in -69.54, -11.42 -60.89, -38.4 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.916 T790M,V948R None None XRAY 1.97 0.191 0.213 C 331 301 13 0 0 13 [[712, 970]] 1.0 4zse Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 7JXMA P00533 700 1007 1210.0 ANP:1101 ATPlike Inactive DFGin 4.958 16.172 BLBtrans -132.35, 172.29 62.1, 35.15 -75.21, 146.26 142.71, 77.54 74.06, -11.26 out-out out 13.894 Saltbr-out 13.34 HRD-in -71.64, -59.02 81.62, -5.92 out-out-none SNCoon out-none ActLoopNT-out 8.072 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 131.88 APE8-dihe-in -79.6, 70.11 APE8-rot-na 34.33 APE67-dihe-in -76.06, -4.61 -47.57, -45.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.53 T790M,V948R None None XRAY 2.192 0.228 0.271 A 331 287 18 0 0 14 [[712, 970]] 1.0 7jxm Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2GS7A P00533 703 1012 1210.0 ANP:60301 ATPlike Inactive DFGin 5.373 16.634 BLBtrans -99.51, 171.1 60.81, 33.31 -69.51, 142.46 163.35, 73.66 92.75, -41.51 out-out out 14.089 Saltbr-out 13.075 HRD-in -69.91, -45.27 73.69, -18.97 out-out-out SNCooo out-out ActLoopNT-out 6.362 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 134.47 APE9-dihe-in -142.48, 136.32 APE8-dihe-in -67.69, 63.71 APE8-rot-na 37.05 APE67-dihe-in -69.28, 11.68 -49.57, -49.09 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.012 APE9-dist-out 8.2 V948R None None XRAY 2.6 0.258 0.298 A 330 281 4 0 0 4 [[712, 970]] 1.0 2gs7 Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2GS7B P00533 701 1016 1210.0 ANP:60302 ATPlike Inactive DFGin 5.284 16.349 BLBtrans -104.25, 165.26 71.85, 26.96 -61.96, 139.7 163.92, 72.26 85.01, -32.88 out-out out 13.995 Saltbr-out 14.309 HRD-in -67.25, -42.1 68.95, -3.07 out-out-none SNCoon out-none ActLoopNT-out 6.473 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 151.84 APE9-dihe-in -148.05, 134.8 APE8-dihe-in -62.95, 72.83 APE8-rot-na 33.79 APE67-dihe-in -67.93, 1.22 -55.72, -45.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.13 APE9-dist-in 7.902 V948R None None XRAY 2.6 0.258 0.298 B 330 288 3 0 0 3 [[712, 970]] 1.0 2gs7 Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3GT8A P00533 700 1014 1210.0 ANP:60002 ATPlike Inactive DFGin 4.993 16.39 BLBtrans -126.87, 160.91 79.29, 15.25 -62.33, 143.15 149.45, 88.24 77.42, 3.92 out-out out 14.088 Saltbr-out 14.957 HRD-in -72.04, -61.33 88.51, -0.69 out-out-none SNCoon out-none ActLoopNT-out 6.56 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 19.46 APE8-rot-na 342.23 APE67-dihe-in -68.79, -19.52 -40.63, -50.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V948R None None XRAY 2.955 0.219 0.275 A 330 300 15 0 0 15 [[712, 970]] 1.0 3gt8 Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3GT8B P00533 701 1007 1210.0 ANP:60001 ATPlike Inactive DFGin 5.247 16.102 BLBtrans -113.7, -174.86 52.25, 31.77 -67.43, 143.58 157.41, 75.54 60.22, 2.12 out-out out 13.355 Saltbr-out 13.716 HRD-in -65.21, -59.58 85.13, -27.25 out-out-none SNCoon out-none ActLoopNT-out 6.384 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 3.18 APE8-rot-na 352.22 APE67-dihe-in -64.44, -9.93 -42.76, -50.36 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V948R None None XRAY 2.955 0.219 0.275 B 330 292 15 0 0 15 [[712, 970]] 1.0 3gt8 Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3GT8C P00533 699 1007 1210.0 ANP:60003 ATPlike Inactive DFGin 4.731 16.042 BLBtrans -111.03, -172.93 50.46, 27.13 -68.53, 136.25 146.08, 72.89 59.13, 17.74 out-out out 14.315 Saltbr-out 13.283 HRD-in -57.94, -53.03 83.1, -30.64 out-out-none SNCoon out-none ActLoopNT-out 6.516 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 131.04 APE8-dihe-in -73.71, 55.48 APE8-rot-na 345.44 APE67-dihe-in -72.77, 4.68 -41.49, -48.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.982 V948R None None XRAY 2.955 0.219 0.275 C 330 296 13 0 0 13 [[712, 970]] 1.0 3gt8 Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3GT8D P00533 701 1010 1210.0 ANP:60004 ATPlike Inactive DFGin 5.236 16.347 BLBtrans -129.98, 167.43 62.52, 32.14 -70.14, 140.82 152.86, 71.47 77.5, -20.57 out-out out 14.059 Saltbr-out 13.514 HRD-in -61.66, -53.51 87.8, -16.84 out-out-none SNCoon out-none ActLoopNT-out 6.797 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 30.46 APE8-rot-na 344.36 APE67-dihe-in -63.75, 2.23 -59.31, -42.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V948R None None XRAY 2.955 0.219 0.275 D 330 295 15 0 0 15 [[712, 970]] 1.0 3gt8 Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CNOA P00533 700 1015 1210.0 ANP:61001 ATPlike Inactive DFGin 5.504 16.161 BLBtrans -118.04, 171.2 68.22, 21.52 -56.79, 132.54 171.14, 68.18 99.53, -19.86 out-out out 13.718 Saltbr-out 12.944 HRD-in -82.44, -48.26 77.49, -9.43 out-out-out SNCooo out-out ActLoopNT-out 6.341 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 122.24 APE9-dihe-in -77.97, 140.5 APE8-dihe-in -80.47, 64.47 APE8-rot-na 27.48 APE67-dihe-in -78.06, -5.87 -50.51, -36.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.588 APE9-dist-out 8.271 V948R None None XRAY 1.55 0.176 0.203 A 330 300 16 0 0 11 [[712, 970]] 1.0 5cno Homo sapiens TYR_EGFR_HUMAN TYR 8.1e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5CNNB P00533 700 1014 1210.0 ANP:61101 ATPlike Inactive DFGin 5.571 16.39 BLBtrans -117.7, 174.34 67.16, 24.17 -60.91, 135.45 168.23, 72.49 97.23, -21.68 out-out out 13.788 Saltbr-out 12.759 HRD-in -80.25, -51.08 77.81, -11.48 out-out-out SNCooo out-out ActLoopNT-out 6.374 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, -75.45 APE9-dihe-in -63.67, 125.67 APE8-dihe-in -78.86, 65.92 APE8-rot-na 30.44 APE67-dihe-in -73.57, -5.24 -51.98, -40.78 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 13.086 APE9-dist-out 8.279 I706Q None None XRAY 1.9 0.183 0.211 B 350 304 11 0 0 11 [[712, 970]] 1.0 5cnn Homo sapiens TYR_EGFR_HUMAN TYR 1.3e-87 299.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5X2AB P00533 700 1022 1210.0 7XO:1105,ANP:1106 Type1,ATPlike Inactive DFGin 5.521 16.379 BLBtrans -118.08, 178.13 68.28, 22.21 -63.57, 132.1 161.37, 67.84 99.95, -15.3 out-out out 13.892 Saltbr-out 13.505 HRD-in -67.87, -49.57 81.65, -13.01 out-out-out SNCooo out-out ActLoopNT-out 6.364 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -63.35, -22.61 APE9-dihe-in -95.03, 108.56 APE8-dihe-in -83.98, 72.85 APE8-rot-na 21.28 APE67-dihe-in -71.39, -9.89 -59.75, -39.3 APE12-dist-na 15.726 APE11-dist-na 13.245 APE10-dist-na 9.274 APE9-dist-in 7.568 T790M,V948R None None XRAY 1.85 0.176 0.219 B 331 322 0 0 0 0 [[712, 970]] 1.0 5x2a Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5X2AA P00533 700 1011 1210.0 7XO:1107,ANP:1108 Type1,Allosteric Inactive DFGin 5.565 16.303 BLBtrans -120.52, 179.71 70.51, 14.21 -61.87, 136.6 165.52, 70.66 90.66, -18.93 out-out out 13.778 Saltbr-out 13.104 HRD-in -79.48, -46.8 73.07, -8.08 out-out-none SNCoon out-none ActLoopNT-out 6.728 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 152.51 APE8-dihe-in -84.48, 76.35 APE8-rot-na 26.1 APE67-dihe-in -71.21, -12.48 -60.14, -38.61 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.762 T790M,V948R None None XRAY 1.85 0.176 0.219 A 331 297 13 0 0 13 [[712, 970]] 1.0 5x2a Homo sapiens TYR_EGFR_HUMAN TYR 6.3e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EPHA2 EPHA2_HUMAN 1MQBA P29317 605 887 976.0 ANP:1000 ATPlike Inactive DFGin 5.712 14.924 BLAminus -127.53, -172.03 57.53, 74.63 -109.94, 122.74 306.64, 100.38 176.53, 104.78 in-out in 8.465 Saltbr-out 5.675 HRD-in -62.1, -45.48 77.42, -17.66 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -37.06 APE9-dihe-in -88.14, 119.95 APE8-dihe-in -73.81, 144.85 APE8-rot-na 33.04 APE67-dihe-in -82.72, 0.0 -54.3, -43.91 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 9.553 APE9-dist-in 5.598 None None None XRAY 2.3 0.237 0.288 A 333 263 20 0 0 17 [[613, 873]] 1.0 1mqb Homo sapiens TYR_EPHA2_HUMAN TYR 7.4e-108 365.7 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 1MQBB P29317 602 883 976.0 ANP:1001 ATPlike None DFGin 5.691 14.889 BLAminus -139.65, -173.77 51.28, 81.33 -92.67, 10.65 292.99, 95.58 -41.77, -44.65 in-in in 8.273 Saltbr-in 2.64 HRD-in -72.65, -50.06 79.19, -16.04 in-in-none SNCiin in-none ActLoopNT-in 2.992 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, -50.3 APE9-dihe-in -134.32, 148.66 APE8-dihe-in -83.15, 83.63 APE8-rot-na 31.61 APE67-dihe-in -80.07, -2.61 -53.54, -47.95 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.328 APE9-dist-in 6.633 None None None XRAY 2.3 0.237 0.288 B 333 265 17 0 0 13 [[613, 873]] 1.0 1mqb Homo sapiens TYR_EPHA2_HUMAN TYR 7.4e-108 365.7 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA2 EPHA2_HUMAN 5I9WA P29317 605 895 976.0 ANP:1001 ATPlike Inactive DFGin 6.244 15.281 BLBminus -125.95, -162.36 67.3, 57.63 -98.89, 156.85 294.37, 103.89 164.47, 175.48 in-in in 8.347 Saltbr-in 2.764 HRD-in -75.49, -48.49 78.15, -15.84 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 123.31 APE8-dihe-in -84.75, 145.17 APE8-rot-na 35.12 APE67-dihe-in -78.8, -3.01 -55.81, -43.34 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 5.342 None None None XRAY 1.359 0.17 0.18 A 306 267 24 0 0 18 [[613, 873]] 1.0 5i9w Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHA3 EPHA3_HUMAN 2QOCA P29320 613 906 983.0 ANP:949 ATPlike Inactive DFGin 4.995 15.445 BLAminus -141.69, -171.73 58.63, 84.29 -97.26, 21.84 297.12, 103.61 -61.69, -31.71 in-out in 9.495 Saltbr-out 6.048 HRD-in -71.05, -48.03 74.01, -8.74 out-in-none SNCoin in-none ActLoopNT-in 3.023 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 135.66 APE9-dihe-in -81.0, 137.87 APE8-dihe-in -77.44, 99.9 APE8-rot-na 34.81 APE67-dihe-in -63.09, -22.76 -54.0, -44.21 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.214 APE9-dist-in 5.514 None None None XRAY 1.25 0.17 0.186 A 344 283 11 0 0 11 [[621, 880]] 1.0 2qoc Homo sapiens TYR_EPHA3_HUMAN TYR 8.4e-111 375.4 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 3FXXA P29320 606 904 983.0 ANP:992 ATPlike Inactive DFGin 4.9 15.171 BLAminus -132.57, -176.13 56.24, 78.37 -91.43, 22.66 298.54, 96.01 -59.15, -30.35 in-out in 9.376 Saltbr-out 4.254 HRD-in -72.67, -46.91 76.32, -4.64 out-in-in SNCoii in-in ActLoopNT-in 2.804 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -67.39, 147.18 APE9-dihe-in -116.01, 151.61 APE8-dihe-in -77.44, 77.25 APE8-rot-na 30.85 APE67-dihe-in -60.25, -20.23 -50.19, -49.06 APE12-dist-na 999.0 APE11-dist-na 8.999 APE10-dist-na 10.183 APE9-dist-in 6.238 A608T None None XRAY 1.7 0.168 0.194 A 371 288 9 0 0 9 [[621, 880]] 1.0 3fxx Homo sapiens TYR_EPHA3_HUMAN TYR 1.1e-110 375.1 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2QO7A P29320 595 904 983.0 ANP:1000 ATPlike Inactive DFGin 5.481 15.556 BLAminus -130.76, -168.32 68.6, 58.57 -92.37, 46.9 297.61, 96.94 -87.84, 999.0 in-out in 8.4 Saltbr-out 4.348 HRD-in -73.41, -45.48 73.79, -12.75 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 85.99 APE8-rot-na 29.77 APE67-dihe-in -61.7, -25.84 -53.26, -41.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None PTR701 PTR701 XRAY 1.605 0.186 0.224 A 373 279 20 0 0 20 [[621, 880]] 1.0 2qo7 Homo sapiens TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2QO9A P29320 608 904 983.0 ANP:948 ATPlike Inactive DFGin 5.205 15.375 BLAminus -133.34, -177.89 59.05, 80.14 -92.65, 15.74 295.85, 100.25 -55.83, -40.55 in-out in 9.235 Saltbr-out 4.23 HRD-in -71.62, -45.86 73.18, -10.67 out-in-out SNCoio in-out ActLoopNT-in 2.997 ActLoopCT-out TYR APEdihe_noiai APEdist_aaai APE10-dihe-none 999.0, 105.46 APE9-dihe-out 41.85, 78.2 APE8-dihe-in -71.02, 94.17 APE8-rot-na 29.94 APE67-dihe-in -61.69, -23.23 -54.76, -43.22 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.168 APE9-dist-in 5.854 None None None XRAY 1.55 0.183 0.211 A 373 277 13 0 0 13 [[621, 880]] 1.0 2qo9 Homo sapiens TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR EPHA3 EPHA3_HUMAN 2QOQA P29320 595 906 983.0 ANP:948 ATPlike None DFGin 5.36 15.575 BLAminus -132.4, -170.9 64.35, 72.55 -105.5, 56.47 301.01, 91.74 -101.2, 999.0 in-in in 8.635 Saltbr-in 2.727 HRD-in -73.3, -48.21 73.66, -6.72 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 133.24 APE9-dihe-in -154.49, 111.52 APE8-dihe-in -76.14, 92.58 APE8-rot-na 29.51 APE67-dihe-in -62.32, -22.8 -60.77, -45.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.743 None PTR701 PTR701 XRAY 1.6 0.19 0.219 A 373 285 18 0 0 18 [[621, 880]] 1.0 2qoq Homo sapiens TYR_EPHA3_HUMAN TYR 1.1e-110 375.0 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 806 794 789 788 787 786 785 784 783 700 Ephrin type-A receptor 3
TYR ERBB3 ERBB3_HUMAN 3KEXA P21860 698 994 1342.0 ANP:60001 ATPlike Pseudo DFGin 5.66 12.692 BLBplus -136.97, 172.9 58.22, 40.12 -96.04, 155.03 48.2, 92.31 69.55, -19.76 out-na out 15.235 Saltbr-na 999.0 HRD-in -90.16, -54.52 74.78, -7.72 na-out-out SNCaoo out-out ActLoopNT-out 6.728 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 138.57 APE8-dihe-out -99.2, 24.49 APE8-rot-na 333.43 APE67-dihe-in -74.24, 11.38 -68.56, -18.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.774 None None None XRAY 2.797 0.243 0.283 A 325 292 5 0 0 5 [[709, 967]] 1.0 3kex Homo sapiens TYR_ERBB3_HUMAN TYR 6e-80 274.2 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 3KEXB P21860 698 988 1342.0 ANP:60002 ATPlike Pseudo DFGin 5.652 12.673 BLBplus -137.46, 172.26 58.51, 39.18 -94.14, 155.27 47.87, 93.32 68.94, -19.33 out-na out 15.232 Saltbr-na 999.0 HRD-in -90.89, -54.23 74.6, -7.22 na-out-out SNCaoo out-out ActLoopNT-out 6.727 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 145.38 APE8-dihe-out -51.8, -10.63 APE8-rot-na 330.98 APE67-dihe-in -73.43, 11.3 -67.12, -27.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.215 None None None XRAY 2.797 0.243 0.283 B 325 283 7 0 0 7 [[709, 967]] 1.0 3kex Homo sapiens TYR_ERBB3_HUMAN TYR 6e-80 274.2 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIWA P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.665 12.919 BLBplus -124.68, 170.7 61.91, 32.93 -86.72, 138.2 53.99, 90.7 80.0, -6.46 out-na out 15.12 Saltbr-na 999.0 HRD-in -76.0, -53.69 67.87, 2.11 na-out-none SNCaon out-none ActLoopNT-out 6.632 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -2.58 APE8-rot-na 28.66 APE67-dihe-in -88.2, -5.19 -70.28, -23.24 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 3.1 0.233 0.287 A 326 269 12 0 0 12 [[709, 967]] 1.0 4riw Homo sapiens TYR_ERBB3_HUMAN TYR 6.1e-80 274.2 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIWC P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.618 13.032 BLBplus -125.06, 170.64 62.1, 33.09 -86.97, 138.33 54.47, 90.5 80.01, -6.38 out-na out 15.49 Saltbr-na 999.0 HRD-in -75.9, -53.21 67.39, 0.69 na-out-out SNCaoo out-out ActLoopNT-out 6.393 ActLoopCT-out TYR APEdihe_oioai APEdist_aaao APE10-dihe-out -113.39, 20.05 APE9-dihe-in -68.39, 127.6 APE8-dihe-out -63.99, -4.42 APE8-rot-na 333.17 APE67-dihe-in -86.76, -6.22 -71.15, -22.24 APE12-dist-na 21.544 APE11-dist-na 20.419 APE10-dist-na 15.408 APE9-dist-out 10.083 None None None XRAY 3.1 0.233 0.287 C 326 275 6 0 0 0 [[709, 967]] 1.0 4riw Homo sapiens TYR_ERBB3_HUMAN TYR 6.1e-80 274.2 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 3LMGA P21860 699 978 1342.0 ANP:60301 ATPlike Pseudo DFGin 5.728 12.964 BLBplus -117.83, 170.87 63.58, 24.7 -69.26, 132.03 43.93, 98.75 70.87, 7.13 out-na out 15.578 Saltbr-na 999.0 HRD-in -64.67, -52.37 74.61, 1.05 na-out-out SNCaoo out-out ActLoopNT-out 6.623 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 104.53 APE8-dihe-out -45.34, -17.97 APE8-rot-na 330.0 APE67-dihe-in -71.66, -7.63 -57.32, -31.37 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.464 None None None XRAY 2.8 0.255 0.285 A 344 268 12 0 0 9 [[709, 967]] 1.0 3lmg Homo sapiens TYR_ERBB3_HUMAN TYR 7.3e-80 274.0 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 3LMGB P21860 699 978 1342.0 ANP:60301 ATPlike Pseudo DFGin 5.789 12.844 BLBplus -113.43, 165.54 66.13, 22.95 -73.3, 147.22 48.63, 94.29 81.01, -18.45 out-na out 15.381 Saltbr-na 999.0 HRD-in -77.74, -52.9 74.69, -13.1 na-out-none SNCaon out-none ActLoopNT-out 6.805 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -22.84 APE8-rot-na 330.0 APE67-dihe-in -67.55, -12.53 -55.83, -37.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.255 0.285 B 344 268 12 0 0 9 [[709, 967]] 1.0 3lmg Homo sapiens TYR_ERBB3_HUMAN TYR 7.3e-80 274.0 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIYA P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.753 12.868 BLBplus -123.9, 168.71 62.98, 31.45 -82.39, 142.59 52.35, 86.17 78.8, -6.78 out-na out 15.044 Saltbr-na 999.0 HRD-in -75.26, -54.75 69.16, 2.85 na-out-none SNCaon out-none ActLoopNT-out 6.45 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -9.22 APE8-rot-na 31.12 APE67-dihe-in -85.56, -1.17 -67.69, -25.89 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 E928G None None XRAY 2.981 0.221 0.267 A 326 269 12 0 0 12 [[709, 967]] 1.0 4riy Homo sapiens TYR_ERBB3_HUMAN TYR 1.3e-79 273.1 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIYC P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.577 13.185 BLBplus -124.39, 168.66 63.11, 31.61 -82.48, 141.95 52.91, 86.81 78.36, -7.08 out-na out 15.605 Saltbr-na 999.0 HRD-in -74.67, -54.96 68.56, 2.02 na-out-out SNCaoo out-out ActLoopNT-out 6.525 ActLoopCT-out TYR APEdihe_oioai APEdist_aaao APE10-dihe-out -99.97, 8.97 APE9-dihe-in -62.65, 132.93 APE8-dihe-out -66.25, -9.79 APE8-rot-na 341.07 APE67-dihe-in -85.25, -1.58 -67.21, -25.34 APE12-dist-na 22.285 APE11-dist-na 20.535 APE10-dist-na 15.613 APE9-dist-out 10.163 E928G None None XRAY 2.981 0.221 0.267 C 326 275 6 0 0 0 [[709, 967]] 1.0 4riy Homo sapiens TYR_ERBB3_HUMAN TYR 1.3e-79 273.1 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIXA P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.534 12.788 BLBplus -125.2, 170.11 60.89, 28.84 -82.14, 140.77 56.51, 90.87 77.72, -6.25 out-na out 15.04 Saltbr-na 999.0 HRD-in -77.1, -53.12 66.52, 0.72 na-out-none SNCaon out-none ActLoopNT-out 6.513 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -5.5 APE8-rot-na 30.9 APE67-dihe-in -82.84, -10.3 -67.07, -25.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Q809R None None XRAY 3.1 0.21 0.258 A 326 269 12 0 0 12 [[709, 967]] 1.0 4rix Homo sapiens TYR_ERBB3_HUMAN TYR 9.7e-80 273.5 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR ERBB3 ERBB3_HUMAN 4RIXC P21860 699 979 1342.0 ANP:61101 ATPlike Pseudo DFGin 5.557 13.116 BLBplus -126.64, 170.72 61.2, 28.92 -82.69, 140.73 56.76, 91.32 77.44, -6.2 out-na out 15.473 Saltbr-na 999.0 HRD-in -76.48, -52.61 66.58, -0.13 na-out-out SNCaoo out-out ActLoopNT-out 6.372 ActLoopCT-out TYR APEdihe_oioai APEdist_aaao APE10-dihe-out -112.15, 5.58 APE9-dihe-in -58.87, 135.06 APE8-dihe-out -71.85, -6.39 APE8-rot-na 348.17 APE67-dihe-in -82.4, -10.58 -67.81, -25.66 APE12-dist-na 21.658 APE11-dist-na 20.612 APE10-dist-na 15.605 APE9-dist-out 9.969 Q809R None None XRAY 3.1 0.21 0.258 C 326 275 6 0 0 0 [[709, 967]] 1.0 4rix Homo sapiens TYR_ERBB3_HUMAN TYR 9.7e-80 273.5 2 260 259 851 852 853 855 857 742 759 763 831 833 832 834 893 881 876 875 874 873 872 871 870 788 Receptor tyrosine-protein kinase erbB-3
TYR FGFR2 FGFR2_HUMAN 5UGLA P21802 468 764 821.0 ANP:802 ATPlike Inactive DFGin 6.732 14.464 BLAminus -137.83, -175.53 60.75, 66.42 -85.03, 17.04 287.79, 92.86 -66.15, -23.38 in-in in 7.669 Saltbr-in 2.761 HRD-in -76.2, -48.26 75.23, -6.81 in-in-out SNCiio in-out ActLoopNT-in 2.865 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.99, 26.82 APE9-dihe-in -107.7, 135.68 APE8-dihe-in -52.5, 118.32 APE8-rot-na 330.79 APE67-dihe-in -70.92, -8.04 -59.23, -38.34 APE12-dist-na 14.887 APE11-dist-na 10.816 APE10-dist-na 7.642 APE9-dist-in 5.103 D650V None None XRAY 1.861 0.221 0.258 A 324 285 12 0 0 0 [[481, 759]] 1.0 5ugl Homo sapiens TYR_FGFR2_HUMAN TYR 4.3e-104 353.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR FGFR2 FGFR2_HUMAN 5UGLB P21802 467 764 821.0 ANP:802 ATPlike Inactive DFGin 6.738 14.48 BLAminus -137.57, -172.18 55.78, 69.64 -87.75, 15.81 286.63, 92.96 -64.54, -22.36 in-in in 7.653 Saltbr-in 2.718 HRD-in -74.83, -48.38 75.49, -7.57 in-in-out SNCiio in-out ActLoopNT-in 2.868 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -111.07, 25.73 APE9-dihe-in -107.84, 135.51 APE8-dihe-in -51.06, 118.2 APE8-rot-na 329.13 APE67-dihe-in -71.28, -8.69 -57.7, -39.45 APE12-dist-na 999.0 APE11-dist-na 10.831 APE10-dist-na 7.669 APE9-dist-in 5.084 D650V None None XRAY 1.861 0.221 0.258 B 324 271 27 0 0 11 [[481, 759]] 1.0 5ugl Homo sapiens TYR_FGFR2_HUMAN TYR 4.3e-104 353.4 1 260 260 643 644 645 647 649 517 534 538 623 625 624 626 685 673 668 667 666 665 664 663 662 565 Fibroblast growth factor receptor 2
TYR HCK HCK_HUMAN 1AD5A P08631 79 526 526.0 ANP:60001 ATPlike Inactive DFGin 6.878 13.556 BLAminus -111.54, 157.75 55.86, 95.53 -99.86, -56.89 321.06, 144.41 -91.88, 132.97 out-out out 13.592 Saltbr-out 14.452 HRD-out -92.59, 96.14 -56.64, -30.38 out-out-out SNCooo out-out ActLoopNT-out 11.414 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -107.24, 53.46 APE9-dihe-in -96.28, 143.43 APE8-dihe-out -62.47, 38.68 APE8-rot-na 35.25 APE67-dihe-in -59.4, -26.12 -40.35, -46.47 APE12-dist-na 11.659 APE11-dist-na 16.604 APE10-dist-na 16.133 APE9-dist-out 10.414 None PTR522 PTR522 XRAY 2.6 0.239 0.307 A 438 438 0 0 0 0 [[262, 513]] 1.0 1ad5 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-88 303.1 1 260 260 398 399 400 402 404 290 305 309 378 380 379 381 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 1AD5B P08631 79 526 526.0 ANP:60532 ATPlike Inactive DFGin 6.635 13.529 BLAminus -108.53, 152.83 57.68, 95.37 -100.87, -57.78 321.85, 133.69 -88.86, 132.45 out-out out 13.591 Saltbr-out 14.334 HRD-out -97.62, 96.0 -55.31, -32.54 out-out-out SNCooo out-out ActLoopNT-out 11.48 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -102.78, 54.95 APE9-dihe-in -97.18, 143.16 APE8-dihe-out -68.08, 36.88 APE8-rot-na 32.16 APE67-dihe-in -59.62, -27.02 -36.62, -45.49 APE12-dist-na 11.684 APE11-dist-na 16.585 APE10-dist-na 16.206 APE9-dist-out 10.534 None PTR522 PTR522 XRAY 2.6 0.239 0.307 B 438 438 0 0 0 0 [[262, 513]] 1.0 1ad5 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-88 303.1 1 260 260 398 399 400 402 404 290 305 309 378 380 379 381 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR IGF1R IGF1R_HUMAN 1JQHA P08069 984 1286 1367.0 ANP:301 ATPlike Inactive DFGin 5.69 16.569 None -66.7, 163.88 -59.45, 151.32 -140.18, 178.07 43.94, 89.38 -106.76, 173.06 in-out in 9.977 Saltbr-out 6.056 HRD-in -50.88, -56.96 74.77, -3.78 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -84.24, 106.81 APE9-dihe-in -58.88, 134.76 APE8-dihe-in -78.96, 121.64 APE8-rot-na 37.96 APE67-dihe-in -60.45, -7.73 -52.46, -43.95 APE12-dist-na 7.157 APE11-dist-na 11.3 APE10-dist-na 15.597 APE9-dist-in 5.8 E979G,Y980S None None XRAY 2.1 0.195 0.219 A 308 291 12 0 0 7 [[999, 1268]] 1.0 1jqh Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 1JQHB P08069 984 1286 1367.0 ANP:302 ATPlike Inactive DFGin 5.687 16.554 None -65.78, 164.4 -59.98, 151.89 -140.81, 178.2 43.68, 89.42 -109.69, -174.77 in-out in 9.988 Saltbr-out 6.019 HRD-in -51.69, -56.66 74.32, -2.97 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -83.6, 107.67 APE9-dihe-in -58.75, 135.36 APE8-dihe-in -79.54, 122.52 APE8-rot-na 37.69 APE67-dihe-in -59.25, -7.46 -52.18, -45.28 APE12-dist-na 6.817 APE11-dist-na 10.932 APE10-dist-na 15.216 APE9-dist-in 5.768 E979G,Y980S None None XRAY 2.1 0.195 0.219 B 308 287 16 0 0 7 [[999, 1268]] 1.0 1jqh Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 1JQHC P08069 984 1286 1367.0 ANP:303 ATPlike Inactive DFGin 5.698 16.558 None -65.47, 162.73 -58.75, 151.62 -140.8, 179.03 43.87, 88.98 -110.24, -177.72 in-out in 9.999 Saltbr-out 6.035 HRD-in -53.2, -57.0 74.59, -2.63 out-none-in SNConi none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.9, 107.89 APE9-dihe-in -58.88, 134.76 APE8-dihe-in -79.04, 122.75 APE8-rot-na 38.27 APE67-dihe-in -60.34, -8.42 -53.61, -43.61 APE12-dist-na 6.926 APE11-dist-na 10.986 APE10-dist-na 15.245 APE9-dist-in 5.774 E979G,Y980S None None XRAY 2.1 0.195 0.219 C 308 291 12 0 0 7 [[999, 1268]] 1.0 1jqh Homo sapiens TYR_IGF1R_HUMAN TYR 1.9e-95 325.0 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR INSR INSR_HUMAN 1IR3A P06213 1008 1310 1382.0 ANP:60300 ATPlike Inactive DFGin 6.128 14.366 BLAminus -133.72, -168.17 47.48, 85.02 -100.33, 24.62 303.32, 104.39 -58.78, -39.74 in-out in 8.923 Saltbr-out 4.393 HRD-in -68.06, -49.87 71.52, -7.17 out-in-in SNCoii in-in ActLoopNT-in 2.902 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -78.98, 116.19 APE9-dihe-in -117.81, 138.98 APE8-dihe-in -77.82, 71.42 APE8-rot-na 34.55 APE67-dihe-in -66.85, -13.55 -40.74, -47.32 APE12-dist-na 14.511 APE11-dist-na 10.427 APE10-dist-na 9.764 APE9-dist-in 6.771 C1008S,Y1011F PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 1.9 0.194 0.226 A 306 303 0 0 0 0 [[1023, 1292]] 1.0 1ir3 Homo sapiens TYR_INSR_HUMAN TYR 1.4e-96 328.7 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR LCK LCK_HUMAN 1QPCA P06239 231 502 509.0 ANP:904 ATPlike Active DFGin 6.61 14.416 BLAminus -133.73, 179.02 58.4, 83.48 -97.79, 21.23 295.19, 99.8 -60.65, -35.99 in-in in 8.702 Saltbr-in 3.096 HRD-in -103.01, -49.32 74.3, -4.36 in-in-in SNCiii in-in ActLoopNT-in 2.921 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -120.97, 142.08 APE9-dihe-in -126.79, 156.19 APE8-dihe-in -63.13, 117.89 APE8-rot-na 333.56 APE67-dihe-in -65.85, -20.96 -57.94, -43.39 APE12-dist-na 14.856 APE11-dist-na 10.005 APE10-dist-na 12.788 APE9-dist-in 6.784 None PTR394 PTR394 XRAY 1.6 0.2 0.23 A 279 272 0 0 0 0 [[245, 496]] 1.0 1qpc Homo sapiens TYR_LCK_HUMAN TYR 1.4e-94 322.2 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
TYR MERTK MERTK_HUMAN 2P0CA Q12866 575 861 999.0 ANP:1 ATPlike Inactive DFGin 5.924 13.136 BLBplus -137.27, 178.6 60.37, 23.32 -81.61, 167.49 49.71, 91.11 85.65, -47.4 out-none out 13.649 Saltbr-none 999.0 HRD-in -80.53, -55.62 75.56, -3.56 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 51.71 APE8-rot-na 32.28 APE67-dihe-in -80.87, -2.88 -33.63, -45.94 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.208 0.274 A 313 249 38 0 0 18 [[587, 856]] 1.0 2p0c Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 2P0CB Q12866 575 861 999.0 ANP:2 ATPlike Inactive DFGin 6.034 13.332 BLBplus -140.6, 176.88 63.43, 26.39 -92.68, 153.87 48.18, 81.79 87.34, -0.94 out-none out 13.973 Saltbr-none 999.0 HRD-in -83.37, -59.67 75.95, 2.32 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.74 APE8-rot-na 27.11 APE67-dihe-in -70.68, -3.16 -43.98, -45.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.208 0.274 B 313 248 39 0 0 18 [[587, 856]] 1.0 2p0c Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MST1R RON_HUMAN 3PLSA Q04912 1060 1357 1400.0 ANP:1358 ATPlike Inactive DFGin 6.296 13.436 BLBplus -158.57, 169.48 54.59, 28.32 -75.35, 163.89 46.83, 88.44 77.37, 8.52 out-out out 14.502 Saltbr-out 15.681 HRD-in -64.04, -56.3 78.09, -13.1 out-out-out SNCooo out-out ActLoopNT-out 7.396 ActLoopCT-out TYR APEdihe_oioai APEdist_aaao APE10-dihe-out -133.31, 27.58 APE9-dihe-in -79.04, 151.37 APE8-dihe-out -60.01, -26.4 APE8-rot-na 344.59 APE67-dihe-in -77.79, -6.02 -43.7, -39.07 APE12-dist-na 21.53 APE11-dist-na 22.492 APE10-dist-na 18.033 APE9-dist-out 10.623 M1254T None None XRAY 2.24 0.235 0.29 A 298 298 0 0 0 0 [[1082, 1343]] 1.0 3pls Homo sapiens TYR_MST1R_HUMAN TYR 3.8e-88 301.1 4 260 257 1225 1226 1227 1229 1231 1114 1131 1135 1205 1207 1206 1208 1269 1257 1252 1251 1250 1249 1248 1247 1246 1162 Macrophage-stimulating protein receptor
TYR MST1R RON_HUMAN 8ZKDA Q04912 1060 1357 1400.0 ANP:1401 ATPlike Inactive DFGin 5.963 13.445 BLBplus -136.42, 163.89 75.82, 17.06 -71.65, 165.79 57.65, 82.07 74.72, 11.98 out-out out 14.72 Saltbr-out 14.955 HRD-in -65.95, -60.68 80.92, -14.74 out-out-out SNCooo out-out ActLoopNT-out 7.373 ActLoopCT-out TYR APEdihe_iooai APEdist_aaao APE10-dihe-in -84.37, 161.73 APE9-dihe-out -52.23, -44.7 APE8-dihe-out -56.31, -27.37 APE8-rot-na 334.62 APE67-dihe-in -83.51, -2.98 -41.89, -46.09 APE12-dist-na 22.059 APE11-dist-na 19.032 APE10-dist-na 14.222 APE9-dist-out 10.029 None None None XRAY 2.05 0.18 0.231 A 298 298 0 0 0 0 [[1082, 1343]] 1.0 8zkd Homo sapiens TYR_MST1R_HUMAN TYR 3.8e-88 301.1 4 260 257 1225 1226 1227 1229 1231 1114 1131 1135 1205 1207 1206 1208 1269 1257 1252 1251 1250 1249 1248 1247 1246 1162 Macrophage-stimulating protein receptor
TYR SRC SRC_HUMAN 2SRCA P12931 87 536 536.0 ANP:60001 ATPlike Inactive DFGin 5.923 13.597 BLBplus -121.59, 173.63 47.36, 36.7 -81.78, 143.05 40.4, 84.17 86.45, -40.21 out-out out 14.118 Saltbr-out 13.928 HRD-in -73.32, -58.33 81.61, -7.89 out-out-out SNCooo out-out ActLoopNT-out 7.541 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.49, -13.33 APE9-dihe-in -91.46, 129.38 APE8-dihe-in -79.29, 62.74 APE8-rot-na 33.55 APE67-dihe-in -68.18, -15.62 -55.52, -29.75 APE12-dist-na 17.379 APE11-dist-na 18.743 APE10-dist-na 13.455 APE9-dist-out 8.746 None PTR530 PTR530 XRAY 1.5 0.226 0.281 A 452 450 0 0 0 0 [[270, 521]] 1.0 2src Homo sapiens TYR_SRC_HUMAN TYR 6.7e-94 320.2 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR SYK KSYK_HUMAN 4FL1A P43405 363 635 635.0 ANP:701 ATPlike Active DFGin 6.669 15.063 BLAminus -122.6, -175.53 56.16, 78.38 -92.62, 24.67 287.04, 93.75 -57.67, -38.36 in-in in 8.059 Saltbr-in 2.683 HRD-in -76.27, -50.57 71.77, 3.28 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -89.55, 85.11 APE9-dihe-in -99.28, 138.37 APE8-dihe-in -79.64, 69.72 APE8-rot-na 29.68 APE67-dihe-in -60.65, -16.95 -44.16, -41.68 APE12-dist-na 13.816 APE11-dist-na 10.806 APE10-dist-na 10.412 APE9-dist-in 7.132 None None None XRAY 1.79 0.197 0.225 A 291 268 5 0 0 0 [[370, 628]] 1.0 4fl1 Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4FL3A P43405 9 635 635.0 ANP:701 ATPlike Inactive DFGin 5.271 12.411 BLBplus -116.27, 169.06 58.02, 22.77 -60.26, 128.95 39.87, 90.8 70.36, 3.28 out-out out 13.347 Saltbr-out 12.957 HRD-in -71.66, -54.51 80.39, -19.8 out-out-none SNCoon out-none ActLoopNT-out 7.03 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 2.25 APE8-rot-na 29.04 APE67-dihe-in -63.72, -20.72 -59.66, -31.5 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y348F,Y352F None None XRAY 1.9 0.18 0.208 A 635 538 13 0 0 13 [[370, 628]] 1.0 4fl3 Homo sapiens TYR_SYK_HUMAN TYR 5.1e-89 304.2 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4FL2A P43405 9 635 635.0 ANP:702 ATPlike Inactive DFGin 5.428 12.328 BLBplus -115.2, 163.41 55.5, 31.26 -66.72, 128.2 35.56, 90.39 65.72, 13.6 out-out out 13.491 Saltbr-out 13.203 HRD-in -70.05, -49.77 75.03, -15.27 out-out-out SNCooo out-out ActLoopNT-out 7.194 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -115.16, 144.55 APE9-dihe-in -104.91, 94.8 APE8-dihe-out -50.62, -30.17 APE8-rot-na 333.32 APE67-dihe-in -61.99, -18.29 -62.08, -21.97 APE12-dist-na 15.556 APE11-dist-na 19.206 APE10-dist-na 15.736 APE9-dist-out 11.527 None None None XRAY 2.19 0.184 0.228 A 636 555 0 0 0 0 [[370, 628]] 1.0 4fl2 Homo sapiens TYR_SYK_HUMAN TYR 5.1e-89 304.2 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR ZAP70 ZAP70_HUMAN 2OZOA P43403 2 606 619.0 ANP:60615 ATPlike Inactive DFGin 5.897 12.889 BLAplus -127.72, 179.11 41.99, 48.0 -92.67, 86.43 47.29, 92.46 138.54, -47.19 out-out out 14.182 Saltbr-out 12.481 HRD-in -87.29, -57.15 80.94, -19.73 out-out-out SNCooo out-out ActLoopNT-out 7.529 ActLoopCT-out TYR APEdihe_nnnao APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 93.52 APE8-rot-na 331.14 APE67-dihe-out -88.9, 16.07 -148.01, 51.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y315F,Y319F,D461N None None XRAY 2.6 0.26 0.29 A 613 538 14 0 0 14 [[338, 595]] 1.0 2ozo Homo sapiens TYR_ZAP70_HUMAN TYR 8.5e-89 303.4 6 259 254 478 479 480 482 484 369 386 390 458 460 459 461 521 509 504 503 502 501 500 499 498 415 Tyrosine-protein kinase ZAP-70
TYR ZAP70 ZAP70_HUMAN 4K2RA P43403 2 606 619.0 ANP:60702 ATPlike Inactive DFGin 5.928 12.438 BLAplus -138.85, 178.0 51.18, 49.01 -84.24, -35.32 31.27, 105.54 -104.96, 20.24 out-out out 14.113 Saltbr-out 13.985 HRD-out -89.83, 129.13 -108.05, -14.5 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -15.2 APE8-dihe-out -67.79, 10.24 APE8-rot-na 350.79 APE67-dihe-in -82.13, -29.45 -101.33, 20.29 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 12.27 D461N None None XRAY 3.0 0.213 0.287 A 614 543 17 0 0 17 [[338, 595]] 1.0 4k2r Homo sapiens TYR_ZAP70_HUMAN TYR 8.6e-89 303.4 6 259 254 478 479 480 482 484 369 386 390 458 460 459 461 521 509 504 503 502 501 500 499 498 415 Tyrosine-protein kinase ZAP-70
OTHER LPL0262 Q5WZW9_LEGPL 5CKWA Q5WZW9 15 404 961.0 ANP:60501 ATPlike Active DFGin 5.948 12.719 BLAminus -133.44, 169.43 70.28, 94.79 -117.83, 12.87 299.33, 117.8 -55.88, -8.97 in-in in 6.71 Saltbr-in 2.716 HRD-na-Q -80.53, -48.66 73.11, 5.26 in-in-in SNCiii in-in ActLoopNT-in 2.927 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -69.26, -22.18 APE9-dihe-na -101.55, 179.41 APE8-dihe-in -117.11, 122.15 APE8-rot-in 302.21 APE67-dihe-in -64.67, -9.61 -57.44, -37.84 APE12-dist-in 11.762 APE11-dist-in 9.709 APE10-dist-in 4.647 APE9-dist-in 3.347 None None None XRAY 2.49 0.207 0.258 A 451 378 5 0 0 0 [[75, 309]] 1.0 5ckw Legionella pneumophila OTHER_LPL0262_LEGPL NEK 4.8e-15 62.8 10 222 213 212 213 214 216 218 104 119 123 192 194 193 195 249 237 232 231 230 229 228 227 226 146 non-specific serine/threonine protein kinase
OTHER LPL0262 Q5WZW9_LEGPL 5CKWB Q5WZW9 1 404 961.0 ANP:60501 ATPlike Active DFGin 6.189 12.674 BLAminus -144.06, 165.73 65.65, 85.18 -109.61, 21.73 306.46, 113.14 -57.87, -17.2 in-in in 6.769 Saltbr-in 2.882 HRD-na-Q -82.05, -45.94 73.24, -7.24 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -76.56, -19.65 APE9-dihe-na -103.71, -175.8 APE8-dihe-in -130.62, 116.65 APE8-rot-in 293.03 APE67-dihe-in -65.48, -28.87 -48.06, -39.07 APE12-dist-in 11.529 APE11-dist-in 9.586 APE10-dist-in 4.483 APE9-dist-in 3.458 None None None XRAY 2.49 0.207 0.258 B 451 399 5 0 0 0 [[75, 309]] 1.0 5ckw Legionella pneumophila OTHER_LPL0262_LEGPL NEK 4.8e-15 62.8 10 222 213 212 213 214 216 218 104 119 123 192 194 193 195 249 237 232 231 230 229 228 227 226 146 non-specific serine/threonine protein kinase
CMGC MAPK A0A3Q8ITZ9_LEIDO 4QNYA A0A3Q8ITZ9 4 350 408.0 ANP:402 ATPlike Inactive DFGin 6.165 14.704 BLAminus -127.76, -174.94 61.93, 78.26 -95.74, 34.98 293.98, 91.09 -76.44, -18.02 in-in in 9.348 Saltbr-in 2.729 HRD-in -68.82, -45.36 71.54, -13.83 in-in-out SNCiio in-out ActLoopNT-in 2.741 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oooo APE10-dihe-na -132.18, 155.62 APE9-dihe-na -94.67, -21.05 APE8-dihe-in -141.24, 100.95 APE8-rot-na 183.02 APE67-dihe-in -68.06, -10.3 -112.98, 4.12 APE12-dist-out 16.023 APE11-dist-out 14.67 APE10-dist-out 11.69 APE9-dist-out 12.567 None None None XRAY 2.257 0.237 0.285 A 354 333 3 0 0 3 [[21, 310]] 1.0 4qny Leishmania donovani CMGC_MAPK_LEIDO CMGC 5.8e-75 258.3 3 301 299 166 167 168 170 172 51 70 74 146 148 147 149 207 194 189 188 187 186 185 184 183 105 Mitogen activated protein kinase, putative
CMGC MAPK A0A3Q8ITZ9_LEIDO 4QNYB A0A3Q8ITZ9 4 350 408.0 ANP:403 ATPlike Inactive DFGin 6.138 14.789 BLAminus -126.8, -176.12 61.38, 78.86 -95.33, 36.88 294.2, 91.77 -77.29, -21.88 in-in in 9.453 Saltbr-in 2.831 HRD-in -69.33, -48.45 68.04, -9.32 in-in-out SNCiio in-out ActLoopNT-in 2.581 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oooo APE10-dihe-na -133.75, 152.71 APE9-dihe-na -90.5, -19.94 APE8-dihe-in -141.35, 99.54 APE8-rot-na 186.55 APE67-dihe-in -67.94, -11.27 -112.59, 3.99 APE12-dist-out 16.148 APE11-dist-out 14.749 APE10-dist-out 11.684 APE9-dist-out 12.642 None None None XRAY 2.257 0.237 0.285 B 354 339 2 0 0 2 [[21, 310]] 1.0 4qny Leishmania donovani CMGC_MAPK_LEIDO CMGC 5.8e-75 258.3 3 301 299 166 167 168 170 172 51 70 74 146 148 147 149 207 194 189 188 187 186 185 184 183 105 Mitogen activated protein kinase, putative
TKL LYK3 LYK3_MEDTR 9GFZA Q6UD73 302 596 620.0 ANP:601 ATPlike Inactive DFGin 5.896 16.319 BLBtrans -112.0, 159.57 61.3, 42.0 -77.09, 135.77 153.85, 71.13 82.14, -2.66 out-out out 14.795 Saltbr-out 16.343 HRD-in -69.33, -37.57 70.07, -2.36 out-out-out SNCooo out-out ActLoopNT-out 6.107 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -140.09, 130.62 APE9-dihe-na 119.67, 164.52 APE8-dihe-in -118.67, 135.65 APE8-rot-in 301.27 APE67-dihe-inflip 89.4, -18.92 -56.77, 138.93 APE12-dist-out 14.646 APE11-dist-in 13.079 APE10-dist-out 9.194 APE9-dist-in 4.309 D459N None None XRAY 2.5 0.211 0.257 A 296 288 7 0 0 4 [[321, 594]] 1.0 9gfz Medicago truncatula TKL_LYK3_MEDTR TKL 3.5e-59 206.5 3 264 262 458 459 460 462 464 349 362 366 438 440 439 441 499 487 482 481 480 479 478 477 476 391 LysM domain receptor-like kinase 3
TKL LYR4 G7K7K0_MEDTR 8PS7B G7K7K0 340 636 660.0 ANP:703 ATPlike Pseudo DFGin 7.768 15.066 BLBminus -155.57, -174.44 55.36, 56.3 -70.81, 152.24 289.97, 66.8 93.85, 156.74 out-out out 15.961 Saltbr-out 14.036 HRD-in -57.6, -55.05 79.6, -10.79 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -72.46, -42.72 APE9-dihe-na -56.2, -52.66 APE8-dihe-out -56.27, -29.69 APE8-rot-out 59.05 APE67-dihe-in -100.31, -14.89 -66.25, -40.12 APE12-dist-in 9.702 APE11-dist-in 13.647 APE10-dist-out 15.243 APE9-dist-out 9.612 None None None XRAY 2.1 0.225 0.269 B 297 274 23 0 0 12 [[360, 633]] 1.0 8ps7 Medicago truncatula TKL_LYR4_MEDTR TKL 4.9e-53 186.3 13 266 254 493 494 495 497 499 379 388 392 473 475 474 476 538 526 521 520 519 518 517 516 515 418 LysM-domain receptor-like kinase
TKL LYR4 G7K7K0_MEDTR 8PS7A G7K7K0 340 636 660.0 ANP:704 ATPlike Pseudo DFGin 7.344 12.491 None -132.7, -71.23 -80.99, 65.77 -101.31, -4.53 43.9, 75.68 -166.17, 141.69 out-out out 12.664 Saltbr-out 13.161 HRD-in -67.54, -63.16 83.85, -10.66 out-out-out SNCooo out-out ActLoopNT-out 9.632 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -64.12, -49.62 APE9-dihe-na -62.67, -34.57 APE8-dihe-out -58.19, -50.78 APE8-rot-in 276.77 APE67-dihe-in -82.12, -28.85 -67.98, -32.83 APE12-dist-out 14.247 APE11-dist-out 19.231 APE10-dist-out 20.4 APE9-dist-out 9.296 None None None XRAY 2.1 0.225 0.269 A 297 279 18 0 0 0 [[360, 633]] 1.0 8ps7 Medicago truncatula TKL_LYR4_MEDTR TKL 4.9e-53 186.3 13 266 254 493 494 495 497 499 379 388 392 473 475 474 476 538 526 521 520 519 518 517 516 515 418 LysM-domain receptor-like kinase
OTHER BUD32 KAE1B_METJA 2VWBA Q58530 1 530 535.0 ANP:1531 Allosteric Inactive DFGin 6.844 17.132 None -120.64, -3.56 -136.03, 137.71 -148.58, 37.82 232.34, 113.93 -66.32, -14.47 in-in in 7.975 Saltbr-in 2.728 HRD-out -83.04, 140.14 -107.29, 16.57 in-in-na SNCiia in-na ActLoopNT-in 2.916 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -66.96, -33.04 APE9-dihe-na -68.59, -42.86 APE8-dihe-na -73.15, -19.01 APE8-rot-na 294.55 APE67-dihe-na -59.99, -36.61 -63.88, -52.94 APE12-dist-na 17.018 APE11-dist-na 12.319 APE10-dist-na 14.969 APE9-dist-na 11.662 None None None XRAY 3.05 0.224 0.301 A 535 519 4 0 0 0 [[334, 534]] 1.0 2vwb Methanocaldococcus jannaschii OTHER_BUD32_METJA TP53RK 8.5e-45 159.9 6 218 213 466 467 468 470 472 360 384 388 448 450 449 451 483 489 484 483 482 481 480 479 478 414 Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
OTHER BUD32 KAE1B_METJA 2VWBB Q58530 1 532 535.0 ANP:1533 Allosteric Inactive DFGin 6.58 16.716 None -128.01, -5.24 -139.71, 160.08 -157.9, 25.33 238.13, 113.59 -41.68, -37.13 in-in in 7.846 Saltbr-in 3.175 HRD-out -90.81, 128.03 -91.65, 20.67 in-in-na SNCiia in-na ActLoopNT-in 2.657 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -74.1, -29.36 APE9-dihe-na -76.07, -42.12 APE8-dihe-na -69.9, -15.57 APE8-rot-na 312.74 APE67-dihe-na -42.13, -37.17 -74.66, -63.72 APE12-dist-na 16.649 APE11-dist-na 12.112 APE10-dist-na 14.818 APE9-dist-na 11.476 None None None XRAY 3.05 0.224 0.301 B 535 507 8 0 0 0 [[334, 534]] 1.0 2vwb Methanocaldococcus jannaschii OTHER_BUD32_METJA TP53RK 8.5e-45 159.9 6 218 213 466 467 468 470 472 360 384 388 448 450 449 451 483 489 484 483 482 481 480 479 478 414 Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
OTHER STT7 C1EBN1_MICCC 4IX5A C1EBN1 151 489 489.0 ANP:60603 none Inactive None 999.0 999.0 None -120.9, 168.56 71.67, 80.19 -91.21, 21.79 297.99, 161.42 -64.36, -22.18 none-na none 999.0 Saltbr-na 999.0 HRD-na-- -71.12, -47.17 73.28, 1.59 na-in-none SNCain in-none ActLoopNT-in 2.913 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.178 0.201 A 350 339 0 0 0 0 [[62, 488]] 1.0 4ix5 Micromonas commoda OTHER_STT7_MICCC CMGC 1.3e-08 61.8 104 156 81 337 338 339 341 343 0 0 0 315 317 316 318 0 0 0 0 0 0 0 0 0 0 Protein kinase domain-containing protein
OTHER STT7 C1EBN1_MICCC 4IX5B C1EBN1 151 489 489.0 ANP:60602 none Inactive None 999.0 999.0 None -122.9, 169.14 69.98, 79.33 -89.65, 21.35 295.31, 157.7 -65.22, -20.9 none-na none 999.0 Saltbr-na 999.0 HRD-na-- -70.35, -44.14 70.61, 3.11 na-in-none SNCain in-none ActLoopNT-in 2.941 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.178 0.201 B 350 339 0 0 0 0 [[62, 488]] 1.0 4ix5 Micromonas commoda OTHER_STT7_MICCC CMGC 1.3e-08 61.8 104 156 81 337 338 339 341 343 0 0 0 315 317 316 318 0 0 0 0 0 0 0 0 0 0 Protein kinase domain-containing protein
AGC PRKACA KAPCA_MOUSE 6MM6C P05132 19 351 351.0 ANP:60402 ATPlike Inactive DFGin 6.78 16.082 ABAminus -110.74, -8.1 -141.78, 125.75 -126.67, 17.79 291.81, 81.75 -52.6, -43.19 out-out out 10.403 Saltbr-out 4.491 HRD-in -64.73, -48.52 44.91, 28.18 out-in-out SNCoio in-out ActLoopNT-in 2.877 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -155.16, 154.51 APE9-dihe-na 131.73, -155.42 APE8-dihe-in -119.09, 141.73 APE8-rot-out 198.33 APE67-dihe-in -57.79, -26.12 -45.84, -50.95 APE12-dist-in 8.53 APE11-dist-in 11.815 APE10-dist-in 6.306 APE9-dist-in 4.503 None TPO198,SEP339 TPO198,SEP339 XRAY 2.39 0.225 0.261 C 339 322 0 0 0 0 [[44, 298]] 1.0 6mm6 Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 6MM6E P05132 19 351 351.0 ANP:60401 ATPlike Inactive DFGin 6.732 15.965 ABAminus -112.26, -9.59 -137.74, 126.1 -127.73, 18.87 290.52, 82.39 -53.04, -44.19 out-out out 10.271 Saltbr-out 5.278 HRD-in -66.74, -47.88 44.41, 27.02 out-in-out SNCoio in-out ActLoopNT-in 2.873 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -157.27, 155.34 APE9-dihe-na 128.78, -154.8 APE8-dihe-in -120.26, 141.99 APE8-rot-out 197.33 APE67-dihe-in -57.79, -26.44 -45.46, -51.33 APE12-dist-in 8.478 APE11-dist-in 11.851 APE10-dist-in 6.331 APE9-dist-in 4.423 None TPO198,SEP339 TPO198,SEP339 XRAY 2.39 0.225 0.261 E 339 320 0 0 0 0 [[44, 298]] 1.0 6mm6 Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 6MM7A P05132 17 351 351.0 ANP:60406 ATPlike Inactive DFGin 6.716 15.428 ABAminus -112.23, -9.6 -137.01, 123.03 -130.15, 19.3 297.15, 81.39 -54.86, -42.58 out-out out 10.282 Saltbr-out 4.623 HRD-in -76.47, -53.66 52.13, 28.38 out-in-out SNCoio in-out ActLoopNT-in 2.863 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -163.99, 161.65 APE9-dihe-na 126.52, -159.69 APE8-dihe-in -119.22, 141.71 APE8-rot-out 195.45 APE67-dihe-in -67.85, -20.3 -44.24, -48.26 APE12-dist-in 8.204 APE11-dist-in 11.125 APE10-dist-in 5.738 APE9-dist-in 3.971 None TPO198,SEP339 TPO198,SEP339 XRAY 1.85 0.213 0.238 A 339 327 0 0 0 0 [[44, 298]] 1.0 6mm7 Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 6MM7D P05132 16 351 351.0 ANP:60405 ATPlike Inactive DFGin 6.652 15.458 ABAminus -113.01, -9.74 -137.13, 123.49 -128.55, 17.46 296.74, 82.18 -52.99, -42.79 out-out out 10.379 Saltbr-out 5.817 HRD-in -73.81, -53.25 53.83, 26.23 out-in-out SNCoio in-out ActLoopNT-in 2.874 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -166.02, 161.72 APE9-dihe-na 122.21, -160.7 APE8-dihe-in -119.01, 142.81 APE8-rot-out 192.42 APE67-dihe-in -67.72, -20.93 -42.31, -48.3 APE12-dist-in 8.21 APE11-dist-in 11.202 APE10-dist-in 5.786 APE9-dist-in 3.961 None TPO198,SEP339 TPO198,SEP339 XRAY 1.85 0.213 0.238 D 339 324 0 0 0 0 [[44, 298]] 1.0 6mm7 Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 6MM8C P05132 16 351 351.0 ANP:60403 ATPlike Inactive DFGin 6.613 15.2 ABAminus -113.8, -10.95 -132.36, 129.54 -134.0, 24.39 301.03, 83.83 -57.02, -38.35 out-out out 10.34 Saltbr-out 7.324 HRD-in -73.54, -53.96 54.41, 29.61 out-in-out SNCoio in-out ActLoopNT-in 2.776 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -159.79, 167.54 APE9-dihe-na 115.95, -161.99 APE8-dihe-in -118.41, 142.14 APE8-rot-out 195.18 APE67-dihe-in -66.48, -19.98 -46.61, -45.65 APE12-dist-in 8.125 APE11-dist-in 11.202 APE10-dist-in 5.834 APE9-dist-in 3.997 None TPO198,SEP339 TPO198,SEP339 XRAY 1.85 0.183 0.221 C 339 325 0 0 0 0 [[44, 298]] 1.0 6mm8 Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 8UKND P05132 16 351 351.0 ANP:60400 ATPlike Inactive DFGin 6.611 14.958 ABAminus -121.75, -47.3 -93.55, 119.31 -121.12, 22.25 288.77, 83.91 -60.17, -43.74 in-out in 9.636 Saltbr-out 4.003 HRD-in -71.48, -47.99 39.7, 38.93 out-in-in SNCoii in-in ActLoopNT-in 2.976 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.1, 161.55 APE9-dihe-na 104.53, 169.82 APE8-dihe-in -72.88, 137.25 APE8-rot-in 280.42 APE67-dihe-in -60.56, -25.71 -55.68, -37.9 APE12-dist-in 8.095 APE11-dist-in 11.236 APE10-dist-in 5.809 APE9-dist-in 4.692 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.75 0.197 0.232 D 339 323 0 0 0 0 [[44, 298]] 1.0 8ukn Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 8UKOE P05132 16 351 351.0 ANP:60403 ATPlike Inactive DFGin 6.036 14.596 ABAminus -122.57, -57.22 -79.99, 109.96 -108.47, 33.73 286.2, 84.93 -64.54, -41.62 in-in in 9.74 Saltbr-in 3.564 HRD-in -78.91, -48.33 66.16, 13.52 in-in-in SNCiii in-in ActLoopNT-in 2.868 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.15, 159.43 APE9-dihe-na 137.57, -133.12 APE8-dihe-in -144.28, 132.68 APE8-rot-in 289.09 APE67-dihe-in -62.87, -18.89 -48.53, -47.79 APE12-dist-in 8.08 APE11-dist-in 11.321 APE10-dist-in 5.83 APE9-dist-in 3.774 None TPO198,SEP339 TPO198,SEP339 XRAY 2.89 0.213 0.259 E 339 336 0 0 0 0 [[44, 298]] 1.0 8uko Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 8UKPE P05132 17 351 351.0 ANP:60402 ATPlike Inactive DFGin 6.134 14.43 ABAminus -106.11, -56.02 -81.74, 124.54 -123.06, 18.4 279.21, 82.41 -57.4, -55.55 in-out in 9.279 Saltbr-out 4.181 HRD-in -89.57, -52.98 66.95, 19.28 out-in-in SNCoii in-in ActLoopNT-in 2.953 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.29, 147.38 APE9-dihe-na 136.74, -150.06 APE8-dihe-in -126.21, 134.43 APE8-rot-in 318.02 APE67-dihe-in -77.56, -4.79 -54.58, -35.83 APE12-dist-in 7.928 APE11-dist-in 10.82 APE10-dist-in 5.185 APE9-dist-in 3.851 None SEP140,TPO198 SEP140,TPO198 XRAY 2.85 0.242 0.281 E 339 323 0 0 0 0 [[44, 298]] 1.0 8ukp Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 7E11A P05132 14 351 351.0 ANP:60401 ATPlike Active DFGin 6.205 14.451 BLAminus -127.38, -169.19 58.28, 74.22 -96.53, 30.74 276.22, 81.09 -66.46, -21.72 in-in in 9.053 Saltbr-in 2.551 HRD-in -91.79, -53.23 62.57, 24.02 in-in-in SNCiii in-in ActLoopNT-in 3.129 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.39, 155.98 APE9-dihe-na 134.96, -158.62 APE8-dihe-in -113.95, 132.34 APE8-rot-in 301.67 APE67-dihe-in -76.79, -1.28 -53.37, -39.68 APE12-dist-in 8.309 APE11-dist-in 11.135 APE10-dist-in 5.71 APE9-dist-in 3.659 None TPO198,SEP339 TPO198,SEP339 XRAY 3.43 0.262 0.317 A 338 337 0 0 0 0 [[44, 298]] 1.0 7e11 Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 6MM5E P05132 16 351 351.0 ANP:60402 ATPlike Inactive DFGin 5.96 14.351 BLAminus -116.65, 159.11 76.02, 91.05 -92.83, 26.22 286.06, 88.09 -52.81, -36.86 in-in in 8.849 Saltbr-in 2.8 HRD-in -83.15, -50.88 72.11, -0.72 in-in-out SNCiio in-out ActLoopNT-in 2.871 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -156.6, 159.33 APE9-dihe-na 129.67, -150.44 APE8-dihe-in -128.62, 141.57 APE8-rot-out 194.03 APE67-dihe-in -68.05, -20.18 -46.89, -45.89 APE12-dist-in 8.207 APE11-dist-in 11.378 APE10-dist-in 5.798 APE9-dist-in 3.776 None TPO198,SEP339 TPO198,SEP339 XRAY 1.95 0.183 0.227 E 339 336 0 0 0 0 [[44, 298]] 1.0 6mm5 Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3PVBA P05132 7 351 351.0 ANP:60400 ATPlike Active DFGin 5.261 14.107 BLAminus -138.85, 171.16 63.11, 82.89 -89.43, -59.95 273.17, 54.43 27.14, -66.26 in-in in 8.685 Saltbr-in 3.476 HRD-in -84.36, -35.8 62.24, -18.82 in-in-in SNCiii in-in ActLoopNT-in 3.217 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -177.84, 157.88 APE9-dihe-na 132.55, -154.74 APE8-dihe-in -122.19, 108.01 APE8-rot-in 318.81 APE67-dihe-in -60.75, -2.24 -13.41, -60.33 APE12-dist-in 7.733 APE11-dist-in 10.579 APE10-dist-in 5.511 APE9-dist-in 4.042 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 3.3 0.242 0.29 A 345 345 0 0 0 0 [[44, 298]] 1.0 3pvb Mus musculus AGC_PRKACA_MOUSE AGC 1.4e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 2QCSA P05132 14 351 351.0 ANP:60400 ATPlike Active DFGin 5.648 14.291 BLAminus -119.78, 176.88 65.56, 77.31 -85.05, 19.39 273.35, 51.28 -44.32, -42.51 in-in in 8.784 Saltbr-in 2.638 HRD-in -93.14, -54.78 73.52, 10.18 in-in-in SNCiii in-in ActLoopNT-in 2.735 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.52, 149.74 APE9-dihe-na 148.64, -142.53 APE8-dihe-in -132.36, 132.12 APE8-rot-in 297.18 APE67-dihe-in -64.67, -25.45 -36.74, -53.73 APE12-dist-in 8.133 APE11-dist-in 11.321 APE10-dist-in 5.851 APE9-dist-in 3.573 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.2 0.194 0.225 A 350 338 0 0 0 0 [[44, 298]] 1.0 2qcs Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3IDBA P05132 9 351 351.0 ANP:60450 ATPlike Active DFGin 5.346 14.413 BLAminus -121.17, -175.1 59.7, 79.28 -94.34, 24.01 267.69, 48.22 -48.56, -33.02 in-in in 8.845 Saltbr-in 2.694 HRD-in -80.07, -50.75 69.18, 11.1 in-in-in SNCiii in-in ActLoopNT-in 2.99 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.99, 160.5 APE9-dihe-na 138.4, -150.07 APE8-dihe-in -124.64, 132.33 APE8-rot-in 296.41 APE67-dihe-in -59.26, -21.93 -30.94, -63.4 APE12-dist-in 8.102 APE11-dist-in 11.573 APE10-dist-in 6.068 APE9-dist-in 3.445 None TPO198,SEP339 TPO198,SEP339 XRAY 1.62 0.206 0.23 A 350 343 0 0 0 0 [[44, 298]] 1.0 3idb Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3IDCA P05132 9 351 351.0 ANP:60450 ATPlike Active DFGin 5.079 14.472 BLAminus -127.31, 174.57 68.22, 96.34 -111.15, 30.11 265.57, 49.45 -62.75, -22.0 in-in in 8.642 Saltbr-in 3.031 HRD-in -69.04, -44.03 64.09, 13.38 in-in-in SNCiii in-in ActLoopNT-in 2.856 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.35, 157.69 APE9-dihe-na 142.7, -132.16 APE8-dihe-in -139.58, 115.88 APE8-rot-in 293.03 APE67-dihe-in -54.66, -5.54 -16.73, -78.3 APE12-dist-in 7.844 APE11-dist-in 11.373 APE10-dist-in 6.164 APE9-dist-in 3.675 None TPO198,SEP339 TPO198,SEP339 XRAY 2.7 0.241 0.319 A 350 343 0 0 0 0 [[44, 298]] 1.0 3idc Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DG0E P05132 11 351 351.0 ANP:60402 ATPlike Active DFGin 5.583 14.342 BLAminus -118.87, 179.66 65.44, 79.89 -93.34, 25.25 272.35, 58.42 -52.71, -36.39 in-in in 8.955 Saltbr-in 2.699 HRD-in -84.35, -52.45 74.02, 7.32 in-in-in SNCiii in-in ActLoopNT-in 2.895 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.07, 161.1 APE9-dihe-na 130.81, -146.6 APE8-dihe-in -130.07, 130.32 APE8-rot-in 303.85 APE67-dihe-in -61.09, -22.5 -44.14, -49.24 APE12-dist-in 8.008 APE11-dist-in 11.498 APE10-dist-in 5.9 APE9-dist-in 3.389 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.0 0.196 0.228 E 350 341 0 0 0 0 [[44, 298]] 1.0 4dg0 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DH7A P05132 16 351 351.0 ANP:60403 ATPlike Active DFGin 5.574 14.349 BLAminus -124.43, -175.45 59.33, 78.79 -93.54, 24.71 270.97, 54.79 -50.12, -38.03 in-in in 9.025 Saltbr-in 2.724 HRD-in -76.49, -50.79 66.5, 11.01 in-in-in SNCiii in-in ActLoopNT-in 2.961 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.18, 162.39 APE9-dihe-na 131.3, -151.54 APE8-dihe-in -126.44, 134.15 APE8-rot-in 300.19 APE67-dihe-in -56.38, -25.77 -37.48, -60.34 APE12-dist-in 8.093 APE11-dist-in 11.455 APE10-dist-in 5.87 APE9-dist-in 3.417 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.8 0.179 0.194 A 350 336 0 0 0 0 [[44, 298]] 1.0 4dh7 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DH8A P05132 16 351 351.0 ANP:60403 ATPlike Active DFGin 5.901 14.014 BLAminus -123.95, -176.77 59.01, 85.18 -98.8, 24.84 279.52, 63.26 -51.76, -30.5 in-in in 8.8 Saltbr-in 2.713 HRD-in -77.99, -56.65 70.43, 3.78 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.95, 158.57 APE9-dihe-na 135.16, -154.79 APE8-dihe-in -124.8, 132.89 APE8-rot-in 296.53 APE67-dihe-in -58.95, -25.2 -38.46, -56.52 APE12-dist-in 8.145 APE11-dist-in 11.475 APE10-dist-in 5.904 APE9-dist-in 3.511 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.3 0.155 0.188 A 350 336 0 0 0 0 [[44, 298]] 1.0 4dh8 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4HPTE P05132 15 351 351.0 ANP:60401 ATPlike Active DFGin 5.748 14.424 BLAminus -115.4, 178.03 67.73, 81.09 -92.11, 21.69 273.09, 55.37 -58.71, -29.4 in-in in 9.053 Saltbr-in 2.66 HRD-in -90.64, -54.09 71.81, 9.39 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.27, 162.98 APE9-dihe-na 129.56, -147.32 APE8-dihe-in -127.39, 129.92 APE8-rot-in 299.02 APE67-dihe-in -63.31, -27.9 -40.61, -49.36 APE12-dist-in 8.069 APE11-dist-in 11.385 APE10-dist-in 5.825 APE9-dist-in 3.573 None TPO198,SEP339 TPO198,SEP339 XRAY 2.15 0.189 0.228 E 350 337 0 0 0 0 [[44, 298]] 1.0 4hpt Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4HPUE P05132 13 351 351.0 ANP:60402 ATPlike Active DFGin 5.551 14.407 BLAminus -117.63, -178.61 63.83, 78.8 -92.22, 24.46 271.46, 55.23 -53.69, -32.94 in-in in 9.031 Saltbr-in 2.692 HRD-in -87.73, -52.35 74.85, 8.01 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.41, 162.17 APE9-dihe-na 134.1, -149.11 APE8-dihe-in -128.69, 136.04 APE8-rot-in 297.56 APE67-dihe-in -58.67, -24.48 -48.3, -49.81 APE12-dist-in 8.063 APE11-dist-in 11.507 APE10-dist-in 5.886 APE9-dist-in 3.403 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.55 0.173 0.194 E 350 339 0 0 0 0 [[44, 298]] 1.0 4hpu Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DFXE P05132 2 351 351.0 ANP:60402 ATPlike Active DFGin 5.524 14.286 BLAminus -116.71, -179.39 66.13, 78.01 -91.08, 23.34 272.63, 51.46 -56.59, -32.27 in-in in 8.873 Saltbr-in 2.729 HRD-in -88.99, -54.58 73.79, 11.03 in-in-in SNCiii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.69, 159.64 APE9-dihe-na 138.16, -148.52 APE8-dihe-in -130.4, 136.32 APE8-rot-in 296.63 APE67-dihe-in -59.91, -24.0 -47.38, -49.37 APE12-dist-in 8.046 APE11-dist-in 11.41 APE10-dist-in 5.819 APE9-dist-in 3.392 K8C SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.35 0.157 0.179 E 350 350 0 0 0 0 [[44, 298]] 1.0 4dfx Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4XW4A P05132 15 351 351.0 ANP:60403 ATPlike Active DFGin 5.673 14.562 BLAminus -117.82, -177.44 65.15, 79.34 -92.69, 26.58 269.45, 57.64 -61.99, -28.36 in-in in 8.931 Saltbr-in 2.858 HRD-in -86.05, -50.94 67.2, 15.72 in-in-in SNCiii in-in ActLoopNT-in 3.014 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.62, 159.69 APE9-dihe-na 135.12, -140.29 APE8-dihe-in -136.84, 125.12 APE8-rot-in 301.75 APE67-dihe-in -61.52, -26.6 -45.5, -44.66 APE12-dist-in 7.961 APE11-dist-in 11.419 APE10-dist-in 5.935 APE9-dist-in 3.664 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.82 0.183 0.24 A 356 337 0 0 0 0 [[44, 298]] 1.0 4xw4 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 7E0ZA P05132 14 351 351.0 ANP:60401 ATPlike Active DFGin 5.566 13.884 BLAminus -118.85, -174.47 59.93, 79.47 -94.43, 25.89 275.59, 63.85 -59.78, -31.6 in-in in 8.624 Saltbr-in 2.978 HRD-in -96.8, -56.38 78.26, 13.74 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.91, 162.74 APE9-dihe-na 131.67, -149.57 APE8-dihe-in -131.04, 130.65 APE8-rot-in 294.41 APE67-dihe-in -63.42, -12.5 -45.48, -52.1 APE12-dist-in 7.9 APE11-dist-in 11.182 APE10-dist-in 5.721 APE9-dist-in 3.4 None TPO198,SEP339 TPO198,SEP339 XRAY 2.162 0.184 0.228 A 358 337 0 0 0 0 [[44, 298]] 1.0 7e0z Mus musculus AGC_PRKACA_MOUSE AGC 1.6e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 7E12A P05132 19 351 351.0 ANP:60401 ATPlike Inactive DFGin 5.396 14.617 BLAminus -131.26, -169.7 58.92, 77.12 -93.02, 37.73 266.27, 47.03 -71.49, -23.13 in-in in 8.807 Saltbr-in 3.266 HRD-out -127.04, 103.44 -105.61, 37.91 in-in-in SNCiii in-in ActLoopNT-in 2.903 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.78, 159.74 APE9-dihe-na 134.39, -158.49 APE8-dihe-in -118.85, 128.69 APE8-rot-in 308.98 APE67-dihe-in -63.3, -26.53 -50.37, -37.69 APE12-dist-in 8.03 APE11-dist-in 11.372 APE10-dist-in 5.965 APE9-dist-in 3.422 None TPO198,SEP339 TPO198,SEP339 XRAY 2.796 0.208 0.252 A 358 333 0 0 0 0 [[44, 298]] 1.0 7e12 Mus musculus AGC_PRKACA_MOUSE AGC 1.6e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DG3E P05132 15 351 351.0 ANP:60401 ATPlike Active DFGin 5.481 14.342 BLAminus -115.99, -176.62 61.62, 77.98 -90.25, 24.84 270.29, 54.4 -55.44, -35.73 in-in in 8.842 Saltbr-in 2.695 HRD-in -87.1, -53.93 73.82, 10.76 in-in-in SNCiii in-in ActLoopNT-in 2.882 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.46, 161.61 APE9-dihe-na 135.41, -150.07 APE8-dihe-in -129.52, 135.22 APE8-rot-in 300.3 APE67-dihe-in -58.11, -23.91 -46.28, -51.67 APE12-dist-in 8.143 APE11-dist-in 11.482 APE10-dist-in 5.886 APE9-dist-in 3.405 R337A SEP140,TPO198 SEP140,TPO198 XRAY 1.8 0.185 0.217 E 371 337 0 0 0 0 [[44, 298]] 1.0 4dg3 Mus musculus AGC_PRKACA_MOUSE AGC 1.8e-94 321.8 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3O7LB P05132 18 351 351.0 ANP:60354 ATPlike Inactive DFGin 5.79 14.666 BLAminus -108.29, -170.95 57.63, 74.91 -94.92, 22.34 267.93, 64.07 -48.2, -34.6 in-in in 9.098 Saltbr-in 2.998 HRD-in -84.13, -53.04 68.25, 25.66 in-in-out SNCiio in-out ActLoopNT-in 2.95 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -140.78, 178.73 APE9-dihe-na 123.03, -156.78 APE8-dihe-in -134.79, 129.02 APE8-rot-out 131.03 APE67-dihe-in -64.87, -13.33 -37.09, -52.44 APE12-dist-in 8.115 APE11-dist-in 11.126 APE10-dist-in 5.593 APE9-dist-in 3.48 None TPO198 TPO198 XRAY 2.8 0.216 0.287 B 350 327 3 0 0 0 [[44, 298]] 1.0 3o7l Mus musculus AGC_PRKACA_MOUSE AGC 8.9e-94 319.5 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3FHIA P05132 14 351 351.0 ANP:60400 ATPlike Active DFGin 5.463 14.263 BLAminus -118.0, -179.45 64.04, 75.7 -86.07, 24.14 267.17, 53.33 -59.82, -32.06 in-in in 8.887 Saltbr-in 2.79 HRD-in -94.84, -53.37 68.02, 7.49 in-in-in SNCiii in-in ActLoopNT-in 2.865 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.67, 136.88 APE9-dihe-na 156.84, -158.52 APE8-dihe-in -126.08, 132.83 APE8-rot-in 296.09 APE67-dihe-in -67.08, -19.88 -42.62, -50.01 APE12-dist-in 8.233 APE11-dist-in 11.12 APE10-dist-in 5.402 APE9-dist-in 3.564 C200A TPO198,SEP339 TPO198,SEP339 XRAY 2.0 0.199 0.226 A 350 338 0 0 0 0 [[44, 298]] 1.0 3fhi Mus musculus AGC_PRKACA_MOUSE AGC 1e-93 319.3 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC RPS6KA3-1 KS6A3_MOUSE 3G51A P18654 47 346 740.0 ANP:480 ATPlike Inactive DFGin 5.92 11.041 None -85.91, -4.29 -148.29, 179.42 -140.68, 33.76 40.5, 80.74 98.88, 16.23 none-none none 999.0 Saltbr-none 999.0 HRD-in -65.38, -43.56 85.71, -58.97 none-out-none SNCnon out-none ActLoopNT-out 10.075 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 76.27 APE8-rot-in 334.43 APE67-dihe-in -57.95, -24.46 -80.48, -16.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.8 0.216 0.248 A 325 280 20 0 0 11 [[68, 327], [422, 679]] 2.0 3g51 Mus musculus AGC_RPS6KA3-1_MOUSE AGC 2.6e-97 330.9 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
CAMK CAMK2A KCC2A_MOUSE 7B56B P11798 5 307 478.0 ANP:60401 ATPlike Active DFGin 6.729 14.232 BLAminus -127.69, 175.68 61.5, 79.97 -89.44, 23.96 289.95, 77.46 -66.33, -24.14 in-in in 8.963 Saltbr-in 2.797 HRD-in -75.83, -42.64 71.61, -6.11 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.35, 145.48 APE9-dihe-na 136.45, -166.63 APE8-dihe-in -115.36, 130.21 APE8-rot-in 297.52 APE67-dihe-in -66.37, -13.84 -48.36, -50.63 APE12-dist-in 10.406 APE11-dist-in 11.67 APE10-dist-in 5.883 APE9-dist-in 3.799 T305A,T306A None None XRAY 1.45 0.191 0.215 B 317 303 0 0 0 0 [[13, 271]] 1.0 7b56 Mus musculus CAMK_CAMK2A_MOUSE CAMK 1.7e-96 328.6 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK MELK MELK_MOUSE 4BFMA Q61846 2 326 643.0 ANP:61000 ATPlike None DFGin 6.712 14.57 BLAminus -130.6, -176.06 61.21, 74.64 -103.71, 23.71 285.06, 77.6 -76.76, -13.34 in-in in 8.847 Saltbr-in 2.958 HRD-in -75.69, -53.65 79.25, -5.08 in-in-none SNCiin in-none ActLoopNT-in 2.981 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 98.82 APE9-dihe-na 96.69, 172.23 APE8-dihe-in -57.02, 129.84 APE8-rot-in 295.1 APE67-dihe-in -57.11, -19.89 -56.29, -48.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.443 APE9-dist-in 3.747 T167E None None XRAY 2.35 0.177 0.208 A 334 308 17 0 0 12 [[11, 263]] 1.0 4bfm Mus musculus CAMK_MELK_MOUSE CAMK 3.3e-88 301.6 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
OTHER POMK SG196_MOUSE 5GZ9A Q3TUA9 54 337 349.0 ANP:1001,MAN:1004 ATPlike,Allosteric Pseudo DFGin 5.293 13.023 ABAminus -119.99, -54.35 -93.01, 108.48 -116.58, 23.4 308.09, 4.31 -55.72, -49.95 none-na none 999.0 Saltbr-na 999.0 HRD-out -81.79, 73.24 -60.09, -38.65 na-in-out SNCaio in-out ActLoopNT-in 3.248 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_iioo APE10-dihe-na -60.33, 128.48 APE9-dihe-na -97.57, 144.89 APE8-dihe-in -131.17, 161.49 APE8-rot-na 301.17 APE67-dihe-out -101.62, -18.24 97.94, -172.65 APE12-dist-in 12.549 APE11-dist-in 13.729 APE10-dist-out 17.531 APE9-dist-out 9.743 N66Q,N164Q None None XRAY 2.4 0.234 0.268 A 305 280 4 0 0 2 [[73, 337]] 1.0 5gz9 Mus musculus OTHER_POMK_MOUSE POMK 1.2e-147 496.2 1 265 265 225 226 227 229 231 107 121 125 200 202 201 203 280 256 251 250 249 248 247 246 245 149 Protein O-mannose kinase
STE STK39 STK39_MOUSE 5DBXA Q9Z1W9 65 365 556.0 ANP:401 ATPlike Inactive DFGin 6.871 15.587 None -61.74, 151.25 -53.68, 129.38 -99.47, -2.77 72.69, 109.41 -58.5, -56.73 out-out out 16.025 Saltbr-out 17.435 HRD-in -69.21, -49.56 75.54, -19.7 out-out-out SNCooo out-out ActLoopNT-out 5.674 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -90.7, -9.1 APE9-dihe-na -96.35, 164.45 APE8-dihe-in -91.01, 125.18 APE8-rot-in 324.0 APE67-dihe-in -65.76, -19.67 -49.27, -43.15 APE12-dist-none 999.0 APE11-dist-out 25.041 APE10-dist-out 28.217 APE9-dist-out 27.348 T243D None CAS71,CAS128,CAS249,CAS346 XRAY 2.5 0.208 0.246 A 328 288 13 0 0 13 [[75, 349]] 1.0 5dbx Mus musculus STE_STK39_MOUSE STE 2.3e-90 308.4 1 257 257 221 222 223 225 227 104 121 125 201 203 202 204 267 254 249 248 247 246 245 244 243 151 STE20/SPS1-related proline-alanine-rich protein kinase
STE STK39 STK39_MOUSE 5DBXB Q9Z1W9 65 364 556.0 ANP:401 ATPlike Inactive DFGin 6.331 15.068 None -67.52, 160.16 -60.64, 125.44 -102.44, -1.98 62.33, 96.08 -52.97, -52.55 out-out out 14.036 Saltbr-out 13.266 HRD-in -73.49, -48.67 74.98, -19.73 out-out-out SNCooo out-out ActLoopNT-out 5.675 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -104.19, 109.41 APE9-dihe-na 87.86, -153.92 APE8-dihe-in -128.52, 139.93 APE8-rot-in 317.58 APE67-dihe-in -74.81, -17.12 -52.01, -48.65 APE12-dist-none 999.0 APE11-dist-out 25.567 APE10-dist-out 25.16 APE9-dist-out 27.74 T243D None CAS71,CAS128,CAS249,CAS346 XRAY 2.5 0.208 0.246 B 328 286 14 0 0 10 [[75, 349]] 1.0 5dbx Mus musculus STE_STK39_MOUSE STE 2.3e-90 308.4 1 257 257 221 222 223 225 227 104 121 125 201 203 202 204 267 254 249 248 247 246 245 244 243 151 STE20/SPS1-related proline-alanine-rich protein kinase
TKL RIPK3 RIPK3_MOUSE 4M69A Q9QZL0 12 312 486.0 ANP:60401 ATPlike Inactive DFGin 6.32 13.402 BLBplus -137.99, 167.73 62.19, 26.69 -80.85, 141.15 41.42, 94.11 79.17, -4.63 out-out out 16.188 Saltbr-out 16.694 HRD-in -64.86, -72.1 85.35, 0.02 out-out-out SNCooo out-out ActLoopNT-out 6.434 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -38.44, -35.37 APE9-dihe-na -67.82, -39.64 APE8-dihe-out -81.63, -25.9 APE8-rot-out 193.07 APE67-dihe-in -56.22, -29.66 -74.57, -26.5 APE12-dist-out 15.23 APE11-dist-out 16.641 APE10-dist-out 19.236 APE9-dist-out 12.364 None SEP184,TPO231,SEP232 SEP184,TPO231,SEP232 XRAY 2.497 0.222 0.246 A 313 287 14 0 0 14 [[20, 290]] 1.0 4m69 Mus musculus TKL_RIPK3_MOUSE TKL 7.1e-60 208.7 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TYR EPHB2 EPHB2_MOUSE 1JPAA P54763 594 892 986.0 ANP:60400 ATPlike Inactive DFGin 5.709 15.489 None -134.81, -163.21 68.34, 57.99 -95.68, 999.0 294.45, 106.32 999.0, 999.0 in-in in 7.779 Saltbr-in 3.019 HRD-in -67.2, -47.6 76.65, -18.41 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -14.15 APE8-rot-na 35.93 APE67-dihe-in -72.25, 3.83 -49.21, -49.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y596F,Y602F None None XRAY 1.91 0.231 0.27 A 312 273 26 0 0 23 [[621, 882]] 1.0 1jpa Mus musculus TYR_EPHB2_MOUSE TYR 5.1e-109 369.5 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR EPHB2 EPHB2_MOUSE 1JPAB P54763 594 891 986.0 ANP:60401 ATPlike Inactive DFGin 5.732 15.627 None -133.42, -158.93 64.89, 61.18 -100.9, 999.0 292.25, 96.96 999.0, 999.0 in-in in 7.815 Saltbr-in 2.686 HRD-in -67.92, -50.57 78.02, -16.62 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -24.77 APE8-rot-na 326.13 APE67-dihe-in -71.91, 4.89 -51.95, -48.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y596F,Y602F None None XRAY 1.91 0.231 0.27 B 312 269 29 0 0 23 [[621, 882]] 1.0 1jpa Mus musculus TYR_EPHB2_MOUSE TYR 5.1e-109 369.5 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR LYN LYN_MOUSE 2ZV8A P25911 239 501 512.0 ANP:60001 ATPlike Active DFGin 6.207 14.166 BLAminus -127.46, 176.54 66.14, 76.26 -98.89, 34.27 306.37, 82.39 -66.23, -26.52 in-in in 8.182 Saltbr-in 2.888 HRD-na-N -93.92, -49.32 76.02, -10.27 in-in-in SNCiii in-in ActLoopNT-in 2.954 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -123.91, 116.52 APE9-dihe-in -60.43, 148.58 APE8-dihe-in -80.52, 92.26 APE8-rot-na 28.17 APE67-dihe-in -68.44, -3.54 -43.41, -52.9 APE12-dist-na 9.634 APE11-dist-na 5.923 APE10-dist-na 9.729 APE9-dist-in 5.004 None None None XRAY 2.7 0.201 0.245 A 279 256 7 0 0 7 [[247, 499]] 1.0 2zv8 Mus musculus TYR_LYN_MOUSE TYR 4.1e-95 323.9 1 260 260 384 385 386 388 390 275 290 294 364 366 365 367 425 413 408 407 406 405 404 403 402 320 Tyrosine-protein kinase Lyn
OTHER PAN3 PAN3_NEUCR 4CZYB Q7SDP4 234 645 656.0 ANP:61650 ATPlike Pseudo DFGin 8.636 12.999 None -108.01, 7.82 -124.9, 18.28 -71.16, 143.54 291.41, 999.0 81.95, -4.35 out-na out 13.97 Saltbr-na 999.0 HRD-in -64.78, -43.28 69.3, -58.59 na-out-na SNCaoa out-na ActLoopNT-out 7.042 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -68.73, -37.24 APE9-dihe-na -75.95, -42.57 APE8-dihe-na -71.33, -35.43 APE8-rot-na 302.88 APE67-dihe-na -61.0, -48.02 -101.37, 21.03 APE12-dist-na 1.544 APE11-dist-na 4.84 APE10-dist-na 5.824 APE9-dist-na 11.769 None None None XRAY 3.4 0.223 0.263 B 429 403 6 0 0 0 [[258, 516]] 1.0 4czy Neurospora crassa OTHER_PAN3_NEUCR PAN3 3.4e-53 189.3 4 264 261 424 425 426 428 430 302 318 322 405 407 406 408 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
OTHER PAN3 PAN3_NEUCR 4CZYD Q7SDP4 234 645 656.0 ANP:61650 ATPlike Pseudo DFGin 8.389 12.627 None -108.63, 8.9 -122.37, 20.29 -71.82, 141.42 292.67, 999.0 81.18, -5.38 out-na out 13.908 Saltbr-na 999.0 HRD-in -65.6, -43.11 68.0, -59.39 na-out-na SNCaoa out-na ActLoopNT-out 6.96 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -69.97, -39.27 APE9-dihe-na -74.97, -41.75 APE8-dihe-na -69.88, -35.71 APE8-rot-na 304.18 APE67-dihe-na -59.83, -48.03 -102.6, 21.19 APE12-dist-na 1.535 APE11-dist-na 4.833 APE10-dist-na 5.688 APE9-dist-na 12.012 None None None XRAY 3.4 0.223 0.263 D 429 403 6 0 0 0 [[258, 516]] 1.0 4czy Neurospora crassa OTHER_PAN3_NEUCR PAN3 3.4e-53 189.3 4 264 261 424 425 426 428 430 302 318 322 405 407 406 408 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
STE MAP2K1 MP2K1_RABIT 7JUWC P29678 40 382 393.0 ANP:401 ATPlike Inactive DFGin 5.476 13.481 BLBplus -119.08, 163.59 62.65, 35.07 -73.68, 154.5 52.17, 104.28 -73.77, 81.69 out-out out 15.47 Saltbr-out 15.978 HRD-in -78.46, -50.39 75.67, -1.62 out-out-out SNCooo out-out ActLoopNT-out 9.094 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -134.09, 125.81 APE9-dihe-na -89.61, -160.68 APE8-dihe-out -92.22, -18.15 APE8-rot-out 194.93 APE67-dihe-out -134.04, 131.23 -117.23, 164.93 APE12-dist-out 17.348 APE11-dist-out 16.614 APE10-dist-out 20.582 APE9-dist-out 12.609 None None None XRAY 2.88 0.245 0.286 C 384 311 32 0 0 0 [[68, 361]] 1.0 7juw Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JURC P29678 41 381 393.0 ANP:401,QOM:402 ATPlike,Type1 Inactive DFGin 6.613 14.002 BLBplus -156.22, 177.66 63.23, 45.15 -109.91, 167.01 49.79, 96.28 -84.59, 94.82 out-out out 15.273 Saltbr-out 15.878 HRD-in -66.44, -49.39 76.73, -8.84 out-out-out SNCooo out-out ActLoopNT-out 9.509 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -118.97, 111.39 APE9-dihe-na -105.66, -145.56 APE8-dihe-out -103.38, -4.62 APE8-rot-out 47.7 APE67-dihe-out -108.36, 139.88 -114.51, 107.19 APE12-dist-out 17.048 APE11-dist-out 19.986 APE10-dist-out 22.012 APE9-dist-out 15.145 None None None XRAY 2.82 0.237 0.277 C 384 304 37 0 0 0 [[68, 361]] 1.0 7jur Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JUTC P29678 41 380 393.0 ANP:401,3EW:402 ATPlike,Type3 Inactive DFGin 6.067 13.94 BLBplus -133.84, -178.36 52.69, 31.27 -86.2, 157.2 55.82, 93.16 -83.8, 97.49 out-out out 15.809 Saltbr-out 15.075 HRD-in -69.63, -49.75 78.05, -10.01 out-out-out SNCooo out-out ActLoopNT-out 9.552 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -106.95, 117.74 APE9-dihe-na -110.82, -149.07 APE8-dihe-out -94.42, -11.28 APE8-rot-out 36.3 APE67-dihe-out -120.05, 132.49 -111.03, 116.45 APE12-dist-out 17.24 APE11-dist-out 19.824 APE10-dist-out 21.751 APE9-dist-out 14.824 None None None XRAY 3.09 0.259 0.3 C 384 303 37 0 0 0 [[68, 361]] 1.0 7jut Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JUUC P29678 43 381 393.0 ANP:401,4BM:402 ATPlike,Type3 Inactive DFGin 6.574 14.008 BLBplus -143.65, 177.32 57.69, 37.46 -92.33, 152.26 41.94, 94.89 -75.77, 92.54 out-out out 15.833 Saltbr-out 14.739 HRD-in -70.37, -49.34 74.88, -6.99 out-out-out SNCooo out-out ActLoopNT-out 9.336 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -102.48, 121.01 APE9-dihe-na -118.18, -151.72 APE8-dihe-out -92.91, -15.39 APE8-rot-out 41.03 APE67-dihe-out -126.24, 128.64 -103.62, 122.66 APE12-dist-out 16.812 APE11-dist-out 19.575 APE10-dist-out 21.5 APE9-dist-out 14.815 None None None XRAY 3.19 0.242 0.258 C 384 302 37 0 0 0 [[68, 361]] 1.0 7juu Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JUVC P29678 41 381 393.0 ANP:401,VKG:402 ATPlike,Type3 Inactive DFGin 6.242 14.018 BLBplus -157.56, 157.79 64.55, 38.6 -93.84, 164.37 42.83, 100.3 -83.58, 81.75 out-out out 16.031 Saltbr-out 15.41 HRD-in -64.23, -51.09 77.84, -3.99 out-out-out SNCooo out-out ActLoopNT-out 9.291 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -121.06, 123.07 APE9-dihe-na -111.51, -147.21 APE8-dihe-out -99.25, -5.79 APE8-rot-out 47.73 APE67-dihe-out -106.23, 137.61 -113.69, 113.69 APE12-dist-out 16.969 APE11-dist-out 20.03 APE10-dist-out 21.614 APE9-dist-out 15.13 None None None XRAY 3.36 0.242 0.255 C 384 304 37 0 0 0 [[68, 361]] 1.0 7juv Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JUXC P29678 40 381 393.0 ANP:401,QOM:402 ATPlike,Type3 Inactive DFGin 6.428 14.356 BLBplus -129.48, -171.66 44.07, 32.82 -84.98, 164.12 41.6, 98.75 -82.14, 71.95 out-out out 17.586 Saltbr-out 20.192 HRD-in -72.38, -56.06 82.77, -10.45 out-out-out SNCooo out-out ActLoopNT-out 9.197 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -105.79, 149.07 APE9-dihe-na -128.12, -140.49 APE8-dihe-out -102.97, -28.75 APE8-rot-out 180.26 APE67-dihe-out -123.35, 132.01 -101.05, 135.7 APE12-dist-out 15.961 APE11-dist-out 18.645 APE10-dist-out 21.127 APE9-dist-out 13.976 None None None XRAY 3.34 0.265 0.283 C 384 308 34 0 0 0 [[68, 361]] 1.0 7jux Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JUYC P29678 40 382 393.0 ANP:401,EUI:402 ATPlike,Type3 Inactive DFGin 5.802 13.945 BLBplus -119.74, 162.94 62.38, 34.15 -75.02, 153.8 53.17, 104.23 -74.72, 81.57 out-out out 15.69 Saltbr-out 15.776 HRD-in -78.99, -50.85 75.95, -2.2 out-out-out SNCooo out-out ActLoopNT-out 8.64 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -134.38, 125.81 APE9-dihe-na -89.68, -160.4 APE8-dihe-out -91.9, -17.82 APE8-rot-out 194.83 APE67-dihe-out -134.16, 130.72 -117.22, 165.02 APE12-dist-out 17.527 APE11-dist-out 16.829 APE10-dist-out 20.535 APE9-dist-out 12.572 None None None XRAY 3.096 0.248 0.257 C 384 311 32 0 0 0 [[68, 361]] 1.0 7juy Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JUZC P29678 40 382 393.0 ANP:401,3EW:402 ATPlike,Type3 Inactive DFGin 5.941 14.245 BLBplus -127.35, 173.99 64.59, 36.11 -89.55, 153.11 55.39, 95.23 -79.11, 95.72 out-out out 16.897 Saltbr-out 15.39 HRD-in -78.66, -56.19 75.89, -1.31 out-out-out SNCooo out-out ActLoopNT-out 8.829 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -140.68, 119.69 APE9-dihe-na -83.26, -173.5 APE8-dihe-out -76.47, -20.99 APE8-rot-out 195.18 APE67-dihe-out -133.01, 129.38 -114.64, 162.26 APE12-dist-out 17.257 APE11-dist-out 16.605 APE10-dist-out 20.455 APE9-dist-out 12.423 None None None XRAY 3.21 0.255 0.272 C 384 308 35 0 0 0 [[68, 361]] 1.0 7juz Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JV0C P29678 40 382 393.0 ANP:401,4BM:402 ATPlike,Type3 Inactive DFGin 5.873 14.27 BLBplus -118.46, 167.04 65.91, 31.94 -77.55, 158.19 54.28, 101.68 -82.73, 82.06 out-out out 16.445 Saltbr-out 16.87 HRD-in -78.95, -48.37 72.45, 0.0 out-out-out SNCooo out-out ActLoopNT-out 8.977 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -134.69, 127.82 APE9-dihe-na -92.23, -161.01 APE8-dihe-out -91.79, -17.2 APE8-rot-out 194.87 APE67-dihe-out -131.33, 129.9 -118.91, 161.4 APE12-dist-out 17.567 APE11-dist-out 16.919 APE10-dist-out 20.798 APE9-dist-out 12.679 None None None XRAY 3.63 0.247 0.26 C 384 308 35 0 0 0 [[68, 361]] 1.0 7jv0 Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JV1C P29678 40 381 393.0 ANP:401,VKG:402 ATPlike,Type3 Inactive DFGin 6.403 13.987 BLBplus -129.45, -171.63 44.64, 33.58 -84.88, 163.88 41.4, 98.6 -82.69, 72.31 out-out out 17.783 Saltbr-out 17.887 HRD-in -72.64, -55.74 83.07, -10.49 out-out-out SNCooo out-out ActLoopNT-out 9.519 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -106.03, 153.74 APE9-dihe-na -129.76, -140.43 APE8-dihe-out -102.55, -29.44 APE8-rot-out 180.23 APE67-dihe-out -122.99, 132.28 -101.94, 135.93 APE12-dist-out 15.759 APE11-dist-out 19.044 APE10-dist-out 21.04 APE9-dist-out 14.153 None None None XRAY 3.62 0.278 0.303 C 384 308 34 0 0 0 [[68, 361]] 1.0 7jv1 Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JUSC P29678 41 381 393.0 VKD:501,ANP:502 Type3,ATPlike Inactive DFGin 6.641 14.136 BLBplus -157.57, 158.09 64.1, 38.39 -94.54, 165.57 43.42, 100.58 -82.33, 83.96 out-out out 16.443 Saltbr-out 17.065 HRD-in -64.72, -50.01 79.43, -5.86 out-out-out SNCooo out-out ActLoopNT-out 9.206 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -121.8, 123.06 APE9-dihe-na -111.39, -149.55 APE8-dihe-out -101.45, -2.19 APE8-rot-out 46.64 APE67-dihe-out -107.18, 138.05 -110.5, 111.25 APE12-dist-out 16.956 APE11-dist-out 19.741 APE10-dist-out 21.584 APE9-dist-out 15.102 None None None XRAY 2.99 0.249 0.265 C 384 304 37 0 0 0 [[68, 361]] 1.0 7jus Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
OTHER PINK1 PINK1_PEDHC 8UYHA E0W1I1 115 574 575.0 ANP:601 ATPlike Active DFGin 9.322 14.819 BLAminus -130.08, -169.42 57.7, 62.71 -86.71, 26.39 286.61, 80.23 -66.61, -35.48 in-in in 7.967 Saltbr-in 3.27 HRD-in -73.02, -43.12 61.9, 7.28 in-in-in SNCiii in-in ActLoopNT-in 2.764 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na 161.16, -131.74 APE9-dihe-na -112.83, -108.55 APE8-dihe-in -69.42, 145.98 APE8-rot-na 76.98 APE67-dihe-in -73.97, -39.08 -95.26, -9.75 APE12-dist-in 8.048 APE11-dist-in 10.262 APE10-dist-in 5.834 APE9-dist-in 3.572 None TPO305 TPO305 EM 2.84 999.0 999.0 A 463 375 49 0 0 0 [[64, 514]] 1.0 8uyh Pediculus humanus OTHER_PINK1_PEDHC PINK1 1e-86 297.1 4 367 364 356 357 358 360 362 193 214 218 331 333 332 334 408 390 385 384 383 382 381 380 379 291 Serine/threonine-protein kinase Pink1, mitochondrial
OTHER PINK1 PINK1_PEDHC 8UYHB E0W1I1 121 574 575.0 ANP:601 ATPlike Active DFGin 9.449 14.871 BLAminus -129.89, -169.12 59.53, 64.83 -87.85, 20.05 283.99, 82.98 -70.23, -23.56 in-in in 7.846 Saltbr-in 2.387 HRD-in -70.23, -41.92 63.21, 0.58 in-in-in SNCiii in-in ActLoopNT-in 2.932 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na 144.56, -157.47 APE9-dihe-na -105.64, -99.0 APE8-dihe-in -70.54, 139.11 APE8-rot-na 52.17 APE67-dihe-in -71.03, -46.42 -78.22, -15.68 APE12-dist-in 7.74 APE11-dist-in 10.385 APE10-dist-in 6.127 APE9-dist-in 3.781 None TPO305 TPO305 EM 2.84 999.0 999.0 B 463 370 50 0 0 0 [[64, 514]] 1.0 8uyh Pediculus humanus OTHER_PINK1_PEDHC PINK1 1e-86 297.1 4 367 364 356 357 358 360 362 193 214 218 331 333 332 334 408 390 385 384 383 382 381 380 379 291 Serine/threonine-protein kinase Pink1, mitochondrial
CAMK CDPK1 CDPK1_PLABA 3Q5IA A0A509AHB6 38 518 523.0 ANP:61634 ATPlike Active DFGin 6.767 14.466 BLAminus -128.23, -176.48 60.5, 79.46 -95.96, 19.56 285.65, 75.94 -57.69, -30.19 in-in in 9.237 Saltbr-in 3.124 HRD-in -79.9, -50.9 74.57, -2.92 in-in-in SNCiii in-in ActLoopNT-in 2.988 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.44, 148.94 APE9-dihe-na 143.23, -165.03 APE8-dihe-in -126.86, 133.51 APE8-rot-in 304.61 APE67-dihe-in -56.9, -32.89 -45.51, -52.84 APE12-dist-in 8.589 APE11-dist-in 11.465 APE10-dist-in 5.667 APE9-dist-in 3.634 None None None XRAY 2.1 0.197 0.25 A 504 461 18 0 0 0 [[57, 324]] 1.0 3q5i Plasmodium berghei CAMK_CDPK1_PLABA CAMK 4e-85 291.5 4 256 253 210 211 212 214 216 86 115 119 187 189 188 190 248 237 232 231 230 229 228 227 226 145 Calcium-dependent protein kinase 1
CMGC MAPK Q7KQK7_PLAF7 3NIEA Q7KQK7 95 499 508.0 ANP:60430 ATPlike Inactive DFGin 6.659 15.776 BLAminus -144.93, -172.32 65.91, 51.77 -86.61, 14.68 283.07, 77.79 -60.63, -18.53 in-in in 8.867 Saltbr-in 2.503 HRD-in -68.06, -47.27 80.58, -8.2 in-in-out SNCiio in-out ActLoopNT-in 2.856 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -70.3, 124.83 APE9-dihe-na -125.0, 112.94 APE8-dihe-in -93.96, 116.45 APE8-rot-in 298.12 APE67-dihe-in -72.32, -16.48 -104.15, 8.37 APE12-dist-out 16.933 APE11-dist-in 12.633 APE10-dist-out 15.244 APE9-dist-out 11.2 None None None XRAY 2.3 0.225 0.268 A 429 364 41 0 0 31 [[106, 446]] 1.0 3nie Plasmodium falciparum CMGC_MAPK_PLAF7 CMGC 8.1e-36 228.5 1 161 305 249 250 251 253 255 135 153 157 229 231 230 232 315 302 297 296 295 294 293 292 291 188 Mitogen-activated protein kinase
CMGC MAPK Q7KQK7_PLAF7 3NIEB Q7KQK7 95 505 508.0 ANP:60430 ATPlike Inactive DFGin 6.221 15.356 BLAminus -134.35, -174.02 73.7, 49.83 -83.77, 18.2 290.52, 87.11 -64.56, -24.17 in-in in 8.768 Saltbr-in 2.61 HRD-in -70.6, -44.59 78.38, -12.33 in-in-out SNCiio in-out ActLoopNT-in 2.654 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -62.89, 130.52 APE9-dihe-na -133.69, 126.34 APE8-dihe-in -95.72, 114.26 APE8-rot-in 300.21 APE67-dihe-in -71.21, -11.01 -104.83, 7.14 APE12-dist-out 17.19 APE11-dist-in 12.78 APE10-dist-out 15.258 APE9-dist-out 11.218 None None None XRAY 2.3 0.225 0.268 B 429 367 44 0 0 32 [[106, 446]] 1.0 3nie Plasmodium falciparum CMGC_MAPK_PLAF7 CMGC 8.1e-36 228.5 1 161 305 249 250 251 253 255 135 153 157 229 231 230 232 315 302 297 296 295 294 293 292 291 188 Mitogen-activated protein kinase
CMGC PSTK1 Q8IL19_PLAF7 3LLTA Q8IL19 535 875 881.0 ANP:877 ATPlike Active DFGin 7.143 15.216 BLAminus -123.92, -179.42 67.73, 65.46 -96.96, 21.34 280.85, 86.26 -60.95, -43.39 in-in in 9.013 Saltbr-in 2.621 HRD-in -67.76, -41.54 71.0, -10.38 in-in-in SNCiii in-in ActLoopNT-in 2.854 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.91, 173.39 APE9-dihe-na 75.57, 154.71 APE8-dihe-in -70.15, 136.15 APE8-rot-in 300.24 APE67-dihe-in -71.32, -17.13 -39.04, -49.24 APE12-dist-in 13.205 APE11-dist-in 11.39 APE10-dist-in 7.514 APE9-dist-in 2.941 None None None XRAY 2.5 0.225 0.267 A 360 341 0 0 0 0 [[552, 874]] 1.0 3llt Plasmodium falciparum CMGC_PSTK1_PLAF7 CMGC 8.3e-71 244.6 2 301 300 719 720 721 723 725 581 596 600 674 676 675 677 756 744 739 738 737 736 735 734 733 631 Protein serine/threonine kinase-1
OTHER PK7 O96214_PLAFA 2PMLX O96214 1 316 320.0 ANP:60381 ATPlike Inactive DFGin 7.27 13.666 BLAminus -145.98, -179.86 51.66, 93.56 -100.75, 34.63 303.23, 91.32 -71.84, -18.04 out-out out 10.157 Saltbr-out 3.691 HRD-in -69.85, -44.18 75.61, 1.42 out-in-in SNCoii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -171.9, 141.96 APE9-dihe-na 131.5, -150.95 APE8-dihe-in -107.69, 124.02 APE8-rot-in 304.33 APE67-dihe-in -76.82, -4.32 -47.17, -48.3 APE12-dist-in 11.287 APE11-dist-in 11.803 APE10-dist-in 6.373 APE9-dist-in 3.68 None None None XRAY 2.6 0.261 0.327 X 348 308 8 0 0 0 [[28, 319]] 1.0 2pml Plasmodium falciparum OTHER_PK7_PLAFA CAMK 9.9e-37 136.1 1 256 256 189 190 191 193 195 55 88 92 169 171 170 172 229 215 210 209 208 207 206 205 204 118 mitogen-activated protein kinase kinase
AGC PKG KGP_PLAVS 5DZCA A5K0N4 1 843 846.0 ANP:61001 ATPlike Inactive DFGin 6.296 14.695 BLAminus -123.96, 179.25 60.5, 83.72 -97.75, 30.63 287.02, 82.05 -66.77, -34.57 out-out out 10.75 Saltbr-out 4.731 HRD-in -75.23, -49.58 78.17, -9.81 out-in-in SNCoii in-in ActLoopNT-in 2.992 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.27, 147.09 APE9-dihe-na 122.94, -168.21 APE8-dihe-in -102.7, 120.96 APE8-rot-in 294.87 APE67-dihe-in -65.78, -22.03 -47.03, -45.8 APE12-dist-in 9.444 APE11-dist-in 11.26 APE10-dist-in 5.39 APE9-dist-in 3.65 None None None XRAY 2.3 0.223 0.255 A 847 815 0 0 0 0 [[534, 791]] 1.0 5dzc Plasmodium vivax AGC_PKG_PLAVS AGC 1.3e-75 260.5 3 260 258 674 675 676 678 680 563 582 586 654 656 655 657 711 699 694 693 692 691 690 689 688 612 cGMP-dependent protein kinase
AGC PRKCB KPCB_RAT 3PFQA P68403 101 668 671.0 ANP:60800 ATPlike Inactive DFGin 6.062 13.318 BLAminus -127.91, -175.53 60.89, 88.17 -109.45, 18.93 297.91, 72.76 -66.81, 8.41 in-out in 9.319 Saltbr-out 4.511 HRD-out -53.59, -66.06 65.15, 50.69 out-in-in SNCoii in-in ActLoopNT-in 3.087 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.97, -178.34 APE9-dihe-na 109.42, -153.48 APE8-dihe-in -112.52, 141.29 APE8-rot-in 328.3 APE67-dihe-in -90.42, -60.35 -50.4, -26.29 APE12-dist-in 8.892 APE11-dist-in 11.964 APE10-dist-in 6.353 APE9-dist-in 4.034 C71S,C217S,R622S TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 4.0 0.244 0.244 A 674 521 0 0 0 0 [[342, 600]] 1.0 3pfq Rattus norvegicus AGC_PRKCB_RAT AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
CMGC MAPK1 MK01_RAT 4S33A P63086 4 355 358.0 ANP:401 ATPlike Inactive DFGin 6.743 16.086 BLAminus -130.86, 178.79 71.13, 76.62 -98.92, 24.03 286.96, 71.68 -62.72, -21.16 in-in in 9.687 Saltbr-in 2.68 HRD-in -72.9, -49.96 78.15, -0.96 in-in-out SNCiio in-out ActLoopNT-in 2.865 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -104.41, -43.84 APE9-dihe-na -64.59, 164.35 APE8-dihe-in -56.21, 123.2 APE8-rot-in 315.9 APE67-dihe-in -61.37, -21.31 -48.55, -49.93 APE12-dist-out 14.732 APE11-dist-in 11.306 APE10-dist-in 7.311 APE9-dist-in 4.483 R65S None None XRAY 1.48 0.199 0.239 A 358 347 0 0 0 0 [[23, 311]] 1.0 4s33 Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.5e-85 293.0 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 4S32A P63086 4 354 358.0 ANP:401 ATPlike Inactive DFGin 6.646 16.335 BLAminus -133.92, 176.75 65.37, 79.23 -97.7, 23.57 287.97, 74.34 -66.64, -19.31 in-out in 9.869 Saltbr-out 3.654 HRD-in -75.76, -45.6 71.68, 4.61 out-in-out SNCoio in-out ActLoopNT-in 2.828 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -98.88, -32.08 APE9-dihe-na -65.5, 159.94 APE8-dihe-in -53.88, 129.7 APE8-rot-in 310.08 APE67-dihe-in -61.98, -20.6 -58.72, -45.65 APE12-dist-out 14.546 APE11-dist-in 11.219 APE10-dist-in 7.49 APE9-dist-in 4.433 None None None XRAY 1.34 0.199 0.231 A 358 346 0 0 0 0 [[23, 311]] 1.0 4s32 Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.3e-85 293.2 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 7UGBA P63086 9 354 358.0 ANP:60401 ATPlike Inactive DFGin 6.844 15.614 BLAminus -132.85, -175.34 66.19, 68.8 -95.15, 22.62 283.13, 71.04 -65.04, -17.4 in-in in 9.298 Saltbr-in 3.095 HRD-in -74.44, -45.95 75.99, -7.39 in-in-out SNCiio in-out ActLoopNT-in 2.76 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -141.06, 152.87 APE9-dihe-na -67.4, -32.8 APE8-dihe-in -151.29, 138.48 APE8-rot-out 186.29 APE67-dihe-in -67.11, -12.06 -109.33, 7.55 APE12-dist-in 8.519 APE11-dist-in 12.19 APE10-dist-out 9.145 APE9-dist-out 11.367 None None None XRAY 1.9 0.181 0.228 A 380 333 9 0 0 9 [[23, 311]] 1.0 7ugb Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.6e-85 292.9 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 4S34A P63086 4 354 358.0 ANP:402 ATPlike Inactive DFGin 6.931 15.921 BLAminus -141.95, 172.44 70.56, 81.84 -99.71, 28.41 294.26, 76.1 -60.19, -38.53 in-out in 9.862 Saltbr-out 3.648 HRD-in -79.44, -51.86 83.9, -4.35 out-in-out SNCoio in-out ActLoopNT-in 2.881 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -91.12, -42.94 APE9-dihe-na -58.97, 168.13 APE8-dihe-in -69.02, 123.37 APE8-rot-in 313.04 APE67-dihe-in -67.86, -24.53 -49.65, -45.75 APE12-dist-out 14.843 APE11-dist-in 11.327 APE10-dist-in 7.277 APE9-dist-in 4.481 I84A None None XRAY 2.5 0.182 0.255 A 358 343 0 0 0 0 [[23, 311]] 1.0 4s34 Rattus norvegicus CMGC_MAPK1_RAT CMGC 2.9e-85 292.1 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 8RQVA P63086 4 354 358.0 ANP:501 ATPlike Inactive DFGin 6.904 16.069 BLAminus -129.6, -175.7 63.15, 70.39 -89.62, 28.98 289.85, 76.4 -67.34, -38.13 in-out in 9.711 Saltbr-out 4.275 HRD-in -67.81, -55.04 72.76, 2.89 out-in-out SNCoio in-out ActLoopNT-in 2.765 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oiii APE10-dihe-na -100.88, -30.73 APE9-dihe-na -77.54, 159.87 APE8-dihe-in -50.38, 124.93 APE8-rot-none 999.0 APE67-dihe-in -63.77, -19.96 -54.06, -49.39 APE12-dist-out 14.154 APE11-dist-in 10.753 APE10-dist-in 7.025 APE9-dist-in 4.35 T188A None None XRAY 2.19 0.22 0.268 A 365 346 0 0 0 0 [[23, 311]] 1.0 8rqv Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.1e-84 290.1 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 8RQXA P63086 4 353 358.0 ANP:501 ATPlike Inactive DFGin 6.753 15.771 BLAminus -131.54, -179.98 70.52, 77.44 -96.49, 23.47 286.75, 76.4 -63.49, -27.29 in-out in 9.283 Saltbr-out 4.03 HRD-in -71.44, -55.38 74.63, 0.71 out-in-out SNCoio in-out ActLoopNT-in 2.862 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oiii APE10-dihe-na -102.41, -41.91 APE9-dihe-na -63.48, 155.78 APE8-dihe-in -53.17, 123.33 APE8-rot-na 196.55 APE67-dihe-in -71.02, -16.45 -50.75, -40.77 APE12-dist-out 14.212 APE11-dist-in 10.768 APE10-dist-in 6.987 APE9-dist-in 4.452 R65S,T188D None None XRAY 1.7 0.199 0.231 A 365 344 0 0 0 0 [[23, 311]] 1.0 8rqx Rattus norvegicus CMGC_MAPK1_RAT CMGC 3.4e-84 288.6 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 8RQWA P63086 4 354 358.0 ANP:501 ATPlike Inactive DFGin 6.849 16.016 BLAminus -129.63, 178.83 67.86, 79.37 -97.6, 20.5 285.29, 78.65 -60.41, -30.78 in-out in 9.771 Saltbr-out 4.065 HRD-in -69.59, -52.69 70.29, 6.23 out-in-out SNCoio in-out ActLoopNT-in 2.837 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oiii APE10-dihe-na -111.03, -43.37 APE9-dihe-na -66.74, 156.04 APE8-dihe-in -59.11, 129.69 APE8-rot-na 165.64 APE67-dihe-in -63.23, -21.3 -54.35, -46.88 APE12-dist-out 14.637 APE11-dist-in 10.923 APE10-dist-in 6.912 APE9-dist-in 4.259 T188E None None XRAY 1.8 0.198 0.231 A 365 344 0 0 0 0 [[23, 311]] 1.0 8rqw Rattus norvegicus CMGC_MAPK1_RAT CMGC 3e-84 288.8 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
OTHER WNK1 WNK1_RAT 5W7TA Q9JIH7 210 482 2126.0 ANP:60501 ATPlike Inactive DFGin 6.417 15.935 BLBtrans -104.69, 171.72 66.72, 19.42 -58.26, 129.69 184.83, 52.8 82.8, 3.34 na-na na 14.539 Saltbr-na 999.0 HRD-in -71.27, -50.06 75.36, -9.98 na-out-out SNCaoo out-out ActLoopNT-out 8.584 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -87.54, -6.4 APE9-dihe-na 140.44, -174.25 APE8-dihe-in -100.52, 116.85 APE8-rot-in 301.69 APE67-dihe-in -56.05, -31.73 -45.94, -43.4 APE12-dist-out 14.878 APE11-dist-in 11.575 APE10-dist-out 12.308 APE9-dist-in 5.421 None SEP382 SEP382 XRAY 2.01 0.175 0.227 A 277 273 0 0 0 0 [[220, 479]] 1.0 5w7t Rattus norvegicus OTHER_WNK1_RAT WNK 1.7e-180 603.7 1 260 260 367 368 369 371 373 250 268 272 346 348 347 349 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_RAT 5W7TB Q9JIH7 210 482 2126.0 ANP:60501 ATPlike Inactive DFGin 6.386 15.245 BLBtrans -103.97, 173.91 64.08, 22.88 -61.0, 131.49 184.03, 62.56 90.07, -15.7 na-na na 14.129 Saltbr-na 999.0 HRD-in -70.75, -51.57 74.83, -5.85 na-out-out SNCaoo out-out ActLoopNT-out 7.222 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -112.88, 5.47 APE9-dihe-na -140.59, -178.52 APE8-dihe-in -108.13, 115.32 APE8-rot-in 305.01 APE67-dihe-in -55.56, -28.14 -49.44, -36.46 APE12-dist-out 14.711 APE11-dist-in 12.593 APE10-dist-in 7.81 APE9-dist-in 4.793 None SEP382 SEP382 XRAY 2.01 0.175 0.227 B 277 273 0 0 0 0 [[220, 479]] 1.0 5w7t Rattus norvegicus OTHER_WNK1_RAT WNK 1.7e-180 603.7 1 260 260 367 368 369 371 373 250 268 272 346 348 347 349 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
AGC CBK1 CBK1_YEAST 4LQSA P53894 294 749 756.0 ANP:801 ATPlike Inactive None 999.0 16.203 None 53.14, -148.73 -160.92, 157.71 -53.16, -18.83 35.56, 134.57 105.29, -25.04 none-none none 999.0 Saltbr-none 999.0 HRD-in -66.84, -59.33 53.37, 19.81 none-out-out SNCnoo out-out ActLoopNT-out 11.527 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na 51.76, -143.69 APE9-dihe-na -76.97, 123.71 APE8-dihe-in -85.35, 159.33 APE8-rot-out 194.03 APE67-dihe-out -98.15, -1.82 -67.37, 76.79 APE12-dist-out 18.628 APE11-dist-out 18.651 APE10-dist-out 15.241 APE9-dist-out 9.908 D475A None None XRAY 3.3 0.272 0.307 A 508 372 59 0 0 44 [[352, 672]] 1.0 4lqs Saccharomyces cerevisiae AGC_CBK1_YEAST AGC 8.9e-95 322.8 1 260 260 492 493 494 496 498 381 400 404 472 474 473 475 593 581 576 575 574 573 572 571 570 430 Serine/threonine-protein kinase CBK1
AGC CBK1 CBK1_YEAST 5NCLA P53894 266 756 756.0 ANP:801 ATPlike Inactive None 999.0 14.768 None -124.95, -0.24 -167.04, -169.57 -142.87, 6.12 315.3, 73.05 87.79, 14.17 none-none none 999.0 Saltbr-none 999.0 HRD-in -82.26, -37.95 50.09, 24.61 none-out-out SNCnoo out-out ActLoopNT-out 10.084 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -121.55, -26.93 APE9-dihe-na 94.26, 55.75 APE8-dihe-in -40.67, 138.08 APE8-rot-out 180.68 APE67-dihe-out -56.77, 157.77 -73.6, -6.03 APE12-dist-out 20.631 APE11-dist-out 16.502 APE10-dist-out 17.631 APE9-dist-out 9.21 D475A None None XRAY 3.15 0.237 0.298 A 508 418 51 0 0 36 [[352, 672]] 1.0 5ncl Saccharomyces cerevisiae AGC_CBK1_YEAST AGC 8.9e-95 322.8 1 260 260 492 493 494 496 498 381 400 404 472 474 473 475 593 581 576 575 574 573 572 571 570 430 Serine/threonine-protein kinase CBK1
AGC CBK1 CBK1_YEAST 4LQPA P53894 282 749 756.0 ANP:801 ATPlike Inactive None 11.349 17.142 None 51.11, -136.69 -160.15, 166.75 -53.4, -31.02 62.24, 131.47 101.1, -24.98 none-none none 999.0 Saltbr-none 999.0 HRD-in -48.74, -51.29 56.68, 17.66 none-out-out SNCnoo out-out ActLoopNT-out 12.107 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na 57.38, -156.31 APE9-dihe-na -77.68, 150.18 APE8-dihe-in -91.6, 155.34 APE8-rot-out 192.52 APE67-dihe-out -54.18, -52.1 -73.01, 58.69 APE12-dist-out 19.628 APE11-dist-out 18.081 APE10-dist-out 14.887 APE9-dist-out 10.605 D475A,T743E None None XRAY 4.5 0.289 0.31 A 508 383 61 0 0 49 [[352, 672]] 1.0 4lqp Saccharomyces cerevisiae AGC_CBK1_YEAST AGC 8.9e-95 322.8 1 260 260 492 493 494 496 498 381 400 404 472 474 473 475 593 581 576 575 574 573 572 571 570 430 Serine/threonine-protein kinase CBK1
AGC CBK1 CBK1_YEAST 4LQQA P53894 282 749 756.0 ANP:801 ATPlike Inactive None 999.0 15.547 None 58.85, -148.63 -164.28, 166.54 -77.58, -28.26 39.76, 84.0 103.41, -23.9 none-none none 999.0 Saltbr-none 999.0 HRD-in -81.04, -47.82 56.38, 16.19 none-out-out SNCnoo out-out ActLoopNT-out 12.343 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na 56.18, -157.99 APE9-dihe-na -70.4, 122.44 APE8-dihe-in -57.31, 154.98 APE8-rot-out 175.08 APE67-dihe-out -48.49, -76.95 -95.03, 72.04 APE12-dist-out 20.096 APE11-dist-out 18.567 APE10-dist-out 14.888 APE9-dist-out 10.347 D475A,T743E None None XRAY 3.6 0.262 0.319 A 508 388 55 0 0 40 [[352, 672]] 1.0 4lqq Saccharomyces cerevisiae AGC_CBK1_YEAST AGC 8.9e-95 322.8 1 260 260 492 493 494 496 498 381 400 404 472 474 473 475 593 581 576 575 574 573 572 571 570 430 Serine/threonine-protein kinase CBK1
CAMK RAD53 RAD53_YEAST 4PDSA P22216 191 490 821.0 ANP:601 ATPlike None DFGin 6.827 15.321 BLAminus -118.08, -171.61 59.64, 71.79 -99.48, 20.29 283.31, 64.09 -58.2, -44.36 in-none in 9.066 Saltbr-none 999.0 HRD-in -71.09, -47.1 62.14, 17.47 none-in-none SNCnin in-none ActLoopNT-in 3.117 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -34.5 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 A225S,D339A None None XRAY 2.9 0.229 0.263 A 347 249 48 0 0 14 [[198, 466]] 1.0 4pds Saccharomyces cerevisiae CAMK_RAD53_YEAST CAMK 1e-76 264.0 3 256 254 338 339 340 342 344 227 244 248 316 318 317 319 390 365 360 359 358 357 356 355 354 274 Serine/threonine-protein kinase RAD53
CAMK RAD53 RAD53_YEAST 4PDSB P22216 191 494 821.0 ANP:601 ATPlike Inactive DFGin 6.718 15.148 BLAminus -117.97, -170.55 58.98, 70.83 -99.5, 20.74 286.63, 66.01 -58.38, -47.1 in-none in 9.184 Saltbr-none 999.0 HRD-in -70.11, -46.34 63.04, 16.89 none-in-out SNCnio in-out ActLoopNT-in 2.981 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 171.9 APE8-rot-out 171.12 APE67-dihe-in -69.32, -29.11 -73.88, 11.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 A225S,D339A None None XRAY 2.9 0.229 0.263 B 347 248 52 0 0 12 [[198, 466]] 1.0 4pds Saccharomyces cerevisiae CAMK_RAD53_YEAST CAMK 1e-76 264.0 3 256 254 338 339 340 342 344 227 244 248 316 318 317 319 390 365 360 359 358 357 356 355 354 274 Serine/threonine-protein kinase RAD53
CAMK RAD53 RAD53_YEAST 5XZVB P22216 32 466 821.0 ANP:60501 ATPlike Inactive DFGin 7.592 14.017 BLBminus -134.96, 173.3 66.26, 62.64 -75.82, 145.77 303.09, 74.83 -59.73, 168.49 out-out out 13.662 Saltbr-out 10.474 HRD-in -60.41, -45.87 73.76, -6.4 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -100.72, 24.79 APE9-dihe-na -115.73, -142.38 APE8-dihe-in -94.48, 113.04 APE8-rot-in 308.94 APE67-dihe-in -48.8, -28.87 -80.72, -18.69 APE12-dist-in 12.623 APE11-dist-out 16.632 APE10-dist-out 16.163 APE9-dist-out 10.329 None None None XRAY 3.1 0.273 0.289 B 471 370 29 0 0 11 [[198, 466]] 1.0 5xzv Saccharomyces cerevisiae CAMK_RAD53_YEAST CAMK 1.6e-78 269.9 3 256 254 338 339 340 342 344 227 244 248 316 318 317 319 390 365 360 359 358 357 356 355 354 274 Serine/threonine-protein kinase RAD53
CAMK RAD53 RAD53_YEAST 5XZVA P22216 16 465 821.0 ANP:60501 ATPlike Inactive DFGin 7.064 15.261 None -121.2, -53.4 -91.08, 125.25 -116.1, 93.37 279.98, 81.22 -112.86, 58.45 in-out in 9.883 Saltbr-out 4.182 HRD-out -106.71, 124.14 -85.03, 170.27 out-out-none SNCoon out-none ActLoopNT-out 5.501 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -63.22, -40.45 999.0, 55.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.1 0.273 0.289 A 471 375 42 0 0 14 [[198, 466]] 1.0 5xzv Saccharomyces cerevisiae CAMK_RAD53_YEAST CAMK 1.6e-78 269.9 3 256 254 338 339 340 342 344 227 244 248 316 318 317 319 390 365 360 359 358 357 356 355 354 274 Serine/threonine-protein kinase RAD53
CMGC CKA1 CSK21_YEAST 4JQEA P15790 3 371 372.0 ANP:401 ATPlike Inactive None 24.244 16.419 None -115.27, -174.34 56.63, 76.24 -90.39, 14.09 294.74, 85.98 -69.15, -20.82 out-na out 38.371 Saltbr-na 999.0 HRD-in -70.11, -50.73 74.01, 10.07 na-in-in SNCaii in-in ActLoopNT-in 2.873 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.74, -177.14 APE9-dihe-na 56.62, -167.2 APE8-dihe-in -120.8, 142.4 APE8-rot-in 319.02 APE67-dihe-in -66.52, -14.17 -32.33, -59.31 APE12-dist-in 12.384 APE11-dist-in 10.377 APE10-dist-in 6.015 APE9-dist-in 3.033 None None None XRAY 1.77 0.206 0.246 A 374 369 0 0 0 0 [[100, 363]] 1.0 4jqe Saccharomyces cerevisiae CMGC_CKA1_YEAST CMGC 0.0001 199.7 1 55 321 213 214 215 217 219 69 114 118 192 194 193 195 253 240 235 234 233 232 231 230 229 153 Casein kinase II subunit alpha
CMGC SKY1 SKY1_YEAST 1Q99A Q03656 143 737 742.0 ANP:60901 ATPlike Active DFGin 5.863 12.817 BLAminus -114.29, -177.44 55.8, 69.3 -86.87, 21.69 289.5, 16.74 -63.01, -13.14 in-in in 9.01 Saltbr-in 3.393 HRD-in -74.14, -46.77 73.71, -6.86 in-in-in SNCiii in-in ActLoopNT-in 2.983 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.75, 166.8 APE9-dihe-na 68.75, 148.0 APE8-dihe-in -82.45, 139.06 APE8-rot-in 296.77 APE67-dihe-in -63.19, -13.43 -18.75, -76.87 APE12-dist-in 12.636 APE11-dist-in 10.441 APE10-dist-in 7.678 APE9-dist-in 2.996 None None None XRAY 2.11 0.22 0.26 A 373 354 9 0 0 0 [[158, 706]] 1.0 1q99 Saccharomyces cerevisiae CMGC_SKY1_YEAST CMGC 8.8e-100 339.7 1 301 301 549 550 551 553 555 187 202 206 291 293 292 294 586 574 569 568 567 566 565 564 563 247 Serine/threonine-protein kinase SKY1
CMGC SKY1 SKY1_YEAST 1Q99B Q03656 142 737 742.0 ANP:60902 ATPlike Active DFGin 6.007 13.076 BLAminus -119.51, 178.42 55.8, 73.86 -88.54, 22.76 281.2, 12.04 -67.31, -20.83 in-in in 8.991 Saltbr-in 3.413 HRD-in -77.35, -48.77 76.96, -6.7 in-in-in SNCiii in-in ActLoopNT-in 3.054 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.48, 168.06 APE9-dihe-na 68.34, 160.67 APE8-dihe-in -99.08, 126.68 APE8-rot-in 289.43 APE67-dihe-in -64.6, -22.58 -5.08, -74.37 APE12-dist-in 12.556 APE11-dist-in 10.321 APE10-dist-in 7.788 APE9-dist-in 3.158 None None None XRAY 2.11 0.22 0.26 B 373 364 0 0 0 0 [[158, 706]] 1.0 1q99 Saccharomyces cerevisiae CMGC_SKY1_YEAST CMGC 8.8e-100 339.7 1 301 301 549 550 551 553 555 187 202 206 291 293 292 294 586 574 569 568 567 566 565 564 563 247 Serine/threonine-protein kinase SKY1
OTHER BUD32 BUD32_YEAST 4WW5A P53323 5 257 261.0 ANP:301 Type1.5_Front Active DFGin 6.754 15.371 BLAminus -131.59, 172.16 63.96, 73.04 -100.08, 21.32 284.27, 93.18 -51.84, -32.53 in-in in 7.658 Saltbr-in 2.783 HRD-in -80.73, -50.01 98.03, -11.27 in-in-na SNCiia in-na ActLoopNT-in 2.88 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -64.97, -44.17 APE9-dihe-na -62.31, -41.0 APE8-dihe-na -66.43, -40.1 APE8-rot-na 172.1 APE67-dihe-na -63.36, -39.55 -55.34, -50.01 APE12-dist-na 15.731 APE11-dist-na 11.145 APE10-dist-na 14.707 APE9-dist-na 11.713 None None None XRAY 1.997 0.185 0.222 A 261 236 21 0 0 0 [[17, 261]] 1.0 4ww5 Saccharomyces cerevisiae OTHER_BUD32_YEAST TP53RK 5e-44 156.6 8 224 217 181 182 183 185 187 52 76 80 158 160 159 161 198 204 199 198 197 196 195 194 193 107 EKC/KEOPS complex subunit BUD32
OTHER GCN2-2 GCN2_YEAST 1ZY5A P15442 594 996 1659.0 ANP:60303 ATPlike Inactive DFGin 6.436 13.948 BLBminus -143.1, -168.47 53.69, 51.66 -54.84, 142.33 286.09, 71.25 -76.51, 124.09 out-out out 12.661 Saltbr-out 11.057 HRD-in -67.81, -47.78 76.36, -17.83 out-out-none SNCoon out-none ActLoopNT-out 8.502 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -71.49, -10.61 999.0, -40.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 R794G None None XRAY 2.0 0.235 0.279 A 303 269 31 0 0 25 [[292, 527], [599, 981]] 2.0 1zy5 Saccharomyces cerevisiae OTHER_GCN2-2_YEAST STE 3.9e-47 167.3 1 254 254 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
OTHER GCN2-2 GCN2_YEAST 1ZY5B P15442 594 983 1659.0 ANP:60304 ATPlike Inactive DFGin 6.603 13.914 BLBminus -140.22, -166.87 36.36, 56.71 -49.57, 149.56 284.28, 69.17 -88.92, 120.77 out-out out 12.825 Saltbr-out 9.799 HRD-in -69.22, -51.57 73.48, -3.27 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -57.67 APE8-dihe-out -69.97, -47.08 APE8-rot-out 170.45 APE67-dihe-in -61.67, -26.23 -38.97, -39.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.754 R794G None None XRAY 2.0 0.235 0.279 B 303 247 40 0 0 29 [[292, 527], [599, 981]] 2.0 1zy5 Saccharomyces cerevisiae OTHER_GCN2-2_YEAST STE 3.9e-47 167.3 1 254 254 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
AGC PRKACA KAPCA_PIG 1CDKA P36887 9 351 351.0 ANP:60400 ATPlike Active DFGin 5.843 14.33 BLAminus -113.76, -166.2 47.38, 80.03 -85.76, 16.06 278.85, 56.4 -55.46, -28.11 in-in in 9.034 Saltbr-in 2.899 HRD-in -94.66, -56.81 78.16, -3.52 in-in-in SNCiii in-in ActLoopNT-in 2.985 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.51, 155.2 APE9-dihe-na 137.51, -153.75 APE8-dihe-in -125.49, 136.2 APE8-rot-in 297.83 APE67-dihe-in -73.46, -24.38 -35.73, -51.43 APE12-dist-in 7.997 APE11-dist-in 11.418 APE10-dist-in 5.766 APE9-dist-in 3.642 None TPO198 TPO198 XRAY 2.0 0.197 999.0 A 350 343 0 0 0 0 [[44, 298]] 1.0 1cdk Sus scrofa AGC_PRKACA_PIG AGC 3.5e-95 324.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_PIG 1CDKB P36887 9 351 351.0 ANP:60400 ATPlike Active DFGin 5.907 14.511 BLAminus -124.27, -171.72 50.82, 76.29 -83.58, 17.26 280.88, 62.25 -47.74, -29.83 in-in in 8.889 Saltbr-in 2.883 HRD-in -87.48, -57.48 77.49, 1.67 in-in-in SNCiii in-in ActLoopNT-in 2.963 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.91, 159.84 APE9-dihe-na 137.3, -140.74 APE8-dihe-in -136.57, 132.27 APE8-rot-in 304.84 APE67-dihe-in -69.16, -27.96 -34.59, -53.92 APE12-dist-in 8.348 APE11-dist-in 11.514 APE10-dist-in 6.08 APE9-dist-in 3.744 None TPO198 TPO198 XRAY 2.0 0.197 999.0 B 350 343 0 0 0 0 [[44, 298]] 1.0 1cdk Sus scrofa AGC_PRKACA_PIG AGC 3.5e-95 324.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
OTHER RNASEL A5H025_PIG 4O1PA A5H025 22 729 743.0 ANP:901,25L:904 ATPlike,Allosteric Inactive DFGin 6.511 12.96 ABAminus -131.33, -33.02 -113.57, 101.31 -107.24, 17.35 306.62, 95.87 -64.46, -18.71 in-in in 7.025 Saltbr-in 2.559 HRD-in -60.39, -60.51 77.09, -8.47 in-in-na SNCiia in-na ActLoopNT-in 2.832 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -142.96, 83.14 APE9-dihe-na -58.16, -26.45 APE8-dihe-na -61.31, -25.89 APE8-rot-na 201.37 APE67-dihe-na -54.23, -32.66 -72.61, -17.63 APE12-dist-na 15.865 APE11-dist-na 12.959 APE10-dist-na 13.132 APE9-dist-na 13.867 None None None XRAY 2.5 0.198 0.231 A 717 672 4 0 0 0 [[351, 591]] 1.0 4o1p Sus scrofa OTHER_RNASEL_PIG RNASEL 2.2e-128 433.7 1 242 242 499 500 501 503 505 390 402 406 479 481 480 482 517 519 514 513 512 511 510 509 508 433 Ribonuclease L
OTHER RNASEL A5H025_PIG 4O1PB A5H025 22 729 743.0 ANP:901,25L:904 ATPlike,Allosteric Inactive DFGin 6.558 12.933 ABAminus -131.25, -34.01 -112.79, 101.17 -107.11, 16.68 306.49, 96.02 -64.91, -18.59 in-in in 7.035 Saltbr-in 2.561 HRD-in -55.77, -50.97 68.09, -3.12 in-in-na SNCiia in-na ActLoopNT-in 2.869 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -144.24, 83.66 APE9-dihe-na -56.74, -27.11 APE8-dihe-na -62.19, -25.6 APE8-rot-na 202.01 APE67-dihe-na -55.19, -32.83 -72.11, -17.43 APE12-dist-na 15.838 APE11-dist-na 12.884 APE10-dist-na 13.127 APE9-dist-na 13.69 None None None XRAY 2.5 0.198 0.231 B 717 671 3 0 0 0 [[351, 591]] 1.0 4o1p Sus scrofa OTHER_RNASEL_PIG RNASEL 2.2e-128 433.7 1 242 242 499 500 501 503 505 390 402 406 479 481 480 482 517 519 514 513 512 511 510 509 508 433 Ribonuclease L
OTHER RNASEL A5H025_PIG 4O1PC A5H025 22 729 743.0 ANP:901,25L:904 ATPlike,Allosteric Inactive DFGin 6.574 12.951 ABAminus -131.64, -33.31 -113.88, 102.15 -109.17, 16.76 306.25, 95.79 -63.9, -18.81 in-in in 7.036 Saltbr-in 2.556 HRD-in -57.15, -62.34 78.43, -4.0 in-in-na SNCiia in-na ActLoopNT-in 2.84 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -142.78, 82.89 APE9-dihe-na -56.9, -26.71 APE8-dihe-na -61.49, -26.14 APE8-rot-na 201.42 APE67-dihe-na -54.45, -32.57 -72.46, -17.58 APE12-dist-na 15.874 APE11-dist-na 12.972 APE10-dist-na 13.122 APE9-dist-na 13.707 None None None XRAY 2.5 0.198 0.231 C 717 673 4 0 0 0 [[351, 591]] 1.0 4o1p Sus scrofa OTHER_RNASEL_PIG RNASEL 2.2e-128 433.7 1 242 242 499 500 501 503 505 390 402 406 479 481 480 482 517 519 514 513 512 511 510 509 508 433 Ribonuclease L
OTHER RNASEL A5H025_PIG 4O1PD A5H025 22 729 743.0 ANP:901,25L:904 ATPlike,Allosteric Inactive DFGin 6.522 12.918 ABAminus -132.11, -32.85 -113.92, 101.55 -106.16, 16.67 306.88, 96.47 -66.56, -17.9 in-in in 7.025 Saltbr-in 2.558 HRD-in -66.2, -51.02 69.27, -3.45 in-in-na SNCiia in-na ActLoopNT-in 2.837 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -143.98, 84.27 APE9-dihe-na -56.61, -27.19 APE8-dihe-na -61.86, -25.69 APE8-rot-na 201.6 APE67-dihe-na -54.63, -32.79 -72.23, -18.0 APE12-dist-na 15.813 APE11-dist-na 12.795 APE10-dist-na 13.098 APE9-dist-na 13.604 None None None XRAY 2.5 0.198 0.231 D 717 668 5 0 0 0 [[351, 591]] 1.0 4o1p Sus scrofa OTHER_RNASEL_PIG RNASEL 2.2e-128 433.7 1 242 242 499 500 501 503 505 390 402 406 479 481 480 482 517 519 514 513 512 511 510 509 508 433 Ribonuclease L
OTHER TCUR0376 D1A2F7_THECD 8CAVA D1A2F7 6 865 865.0 ANP:61003 Allosteric Inactive DFGout 25.029 13.806 None -136.61, -176.07 50.55, 90.07 -109.52, 39.53 298.71, 97.0 -61.52, -45.79 out-na out 23.304 Saltbr-na 999.0 HRD-in -69.88, -46.85 69.44, -25.22 na-in-out SNCaio in-out ActLoopNT-in 3.046 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na 151.19, 133.67 APE9-dihe-na -156.32, 163.61 APE8-dihe-in -115.94, 119.26 APE8-rot-in 286.11 APE67-dihe-inflip 85.43, -34.6 -53.57, 131.45 APE12-dist-out 4.165 APE11-dist-in 8.343 APE10-dist-in 6.311 APE9-dist-in 5.642 None None None XRAY 2.87 0.24 0.293 A 865 860 0 0 0 0 [[216, 447]] 1.0 8cav Thermomonospora curvata OTHER_TCUR0376_THECD OTHER 2.3e-11 51.4 3 202 200 367 368 369 371 373 245 255 255 346 348 347 349 402 390 385 384 383 382 381 380 379 255 Serine/threonine protein kinase
OTHER TCUR0376 D1A2F7_THECD 8CAVB D1A2F7 6 863 865.0 ANP:61102 Allosteric Inactive DFGout 25.219 13.273 None -136.17, 0.21 -151.94, 106.25 -116.71, 46.61 337.45, 77.06 -61.98, -44.38 out-na out 23.216 Saltbr-na 999.0 HRD-in -72.63, -51.39 72.73, -38.34 na-in-out SNCaio in-out ActLoopNT-in 3.126 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na 155.97, 136.86 APE9-dihe-na -156.68, 147.71 APE8-dihe-in -106.12, 118.89 APE8-rot-in 302.92 APE67-dihe-inflip 84.82, -43.75 -50.92, 139.58 APE12-dist-out 4.031 APE11-dist-in 8.215 APE10-dist-in 6.529 APE9-dist-in 5.969 None None None XRAY 2.87 0.24 0.293 B 865 858 0 0 0 0 [[216, 447]] 1.0 8cav Thermomonospora curvata OTHER_TCUR0376_THECD OTHER 2.3e-11 51.4 3 202 200 367 368 369 371 373 245 255 255 346 348 347 349 402 390 385 384 383 382 381 380 379 255 Serine/threonine protein kinase
CAMK CDPK1 Q9BJF5_TOXGO 4IEBA Q9BJF5 32 507 507.0 ANP:60605 ATPlike Inactive DFGin 6.554 15.761 BLAminus -118.12, -178.54 57.22, 81.05 -93.39, 22.31 283.83, 75.07 -62.91, -21.06 out-out out 10.786 Saltbr-out 8.183 HRD-in -78.1, -52.4 75.27, -1.01 out-in-in SNCoii in-in ActLoopNT-in 2.972 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.38, 132.65 APE9-dihe-na 150.75, -159.18 APE8-dihe-in -127.81, 136.94 APE8-rot-in 296.09 APE67-dihe-in -59.35, -29.22 -49.66, -52.18 APE12-dist-in 8.747 APE11-dist-in 11.876 APE10-dist-in 6.073 APE9-dist-in 3.686 G128M None None XRAY 2.05 0.176 0.217 A 515 471 4 0 0 0 [[51, 308]] 1.0 4ieb Toxoplasma gondii CAMK_CDPK1_TOXGO CAMK 1.4e-91 312.8 1 256 256 194 195 196 198 200 80 99 103 171 173 172 174 232 221 216 215 214 213 212 211 210 129 non-specific serine/threonine protein kinase
CAMK CDPK1 Q9BJF5_TOXGO 3HX4A Q9BJF5 30 503 507.0 ANP:605 ATPlike Inactive DFGin 6.376 15.597 BLAminus -124.93, -178.11 57.55, 76.18 -93.17, 21.06 281.41, 72.38 -57.25, -28.44 out-out out 10.43 Saltbr-out 8.082 HRD-in -82.41, -52.5 74.03, -1.03 out-in-in SNCoii in-in ActLoopNT-in 2.926 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.23, 136.25 APE9-dihe-na 150.35, -156.09 APE8-dihe-in -126.64, 138.87 APE8-rot-in 302.17 APE67-dihe-in -62.12, -29.95 -51.48, -47.24 APE12-dist-in 8.582 APE11-dist-in 12.055 APE10-dist-in 6.188 APE9-dist-in 3.646 None None None XRAY 1.95 0.212 0.257 A 508 467 7 0 0 0 [[51, 308]] 1.0 3hx4 Toxoplasma gondii CAMK_CDPK1_TOXGO CAMK 5.2e-90 307.5 1 256 256 194 195 196 198 200 80 99 103 171 173 172 174 232 221 216 215 214 213 212 211 210 129 non-specific serine/threonine protein kinase
CAMK CDPK1 Q9BJF5_TOXGO 3KU2A Q9BJF5 44 507 507.0 ANP:508 ATPlike Inactive None 11.477 17.939 None -100.99, 156.17 73.53, 18.21 -64.25, 133.09 244.39, 100.2 75.66, -4.53 out-none out 14.497 Saltbr-none 999.0 HRD-in -80.49, -57.8 77.94, -40.26 none-out-out SNCnoo out-out ActLoopNT-out 5.721 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -61.85, 129.57 APE9-dihe-na 74.83, 23.66 APE8-dihe-out -106.17, -37.64 APE8-rot-out 63.52 APE67-dihe-in -62.81, -37.67 -61.55, -28.62 APE12-dist-out 14.055 APE11-dist-out 16.655 APE10-dist-out 19.069 APE9-dist-out 12.042 None None None XRAY 2.3 0.198 0.236 A 507 457 0 0 0 0 [[51, 308]] 1.0 3ku2 Toxoplasma gondii CAMK_CDPK1_TOXGO CAMK 5.2e-90 307.5 1 256 256 194 195 196 198 200 80 99 103 171 173 172 174 232 221 216 215 214 213 212 211 210 129 non-specific serine/threonine protein kinase
OTHER ROP18 ROP18_TOXGO 4JRNA Q2PAY2 187 548 554.0 ANP:601 Allosteric None DFGin 8.982 15.869 BLAminus -128.68, -167.44 58.76, 57.13 -87.53, 25.8 281.08, 82.06 -67.92, -21.93 in-in in 8.183 Saltbr-in 2.992 HRD-in -70.13, -31.0 63.02, -2.32 in-in-none SNCiin in-none ActLoopNT-in 2.384 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_inni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 178.51 APE8-dihe-in -78.23, 127.04 APE8-rot-in 289.7 APE67-dihe-inflip 110.21, -8.27 -63.71, 127.69 APE12-dist-in 10.007 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.276 None None None XRAY 2.71 0.235 0.289 A 372 349 6 0 0 2 [[253, 531]] 1.0 4jrn Toxoplasma gondii OTHER_ROP18_TOXGO CAMK 0.04 76.6 5 55 197 426 427 428 430 432 281 300 304 406 408 407 409 465 450 445 444 443 442 441 440 439 0 Serine/threonine-protein kinase ROP18
OTHER PINK1 PINK1_TRICA 5YJ9D D6WMX4 166 570 570.0 ANP:601 ATPlike Inactive DFGin 9.502 15.283 ABAminus -117.37, -38.64 -95.18, 97.77 -99.2, 13.92 280.74, 77.89 -62.77, -17.79 in-in in 7.836 Saltbr-in 2.58 HRD-out -70.37, 137.63 -130.59, 22.41 in-in-out SNCiio in-out ActLoopNT-in 2.579 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_iiii APE10-dihe-na -154.61, -176.52 APE9-dihe-na -54.92, 113.48 APE8-dihe-in -53.26, 148.57 APE8-rot-na 309.64 APE67-dihe-out -106.62, -9.97 -172.9, 165.52 APE12-dist-in 7.975 APE11-dist-in 11.272 APE10-dist-in 7.159 APE9-dist-in 3.217 S205D,S377D,T386E,T530E None MSE197,MSE198,MSE208,MSE214,MSE223,MSE288,MSE294,MSE328,MSE380,MSE389 XRAY 2.53 0.23 0.243 D 423 343 56 0 0 0 [[61, 504]] 1.0 5yj9 Tribolium castaneum OTHER_PINK1_TRICA PINK1 5.8e-86 294.6 5 367 363 358 359 360 362 364 196 217 221 334 336 335 337 410 392 387 386 385 384 383 382 381 295 Serine/threonine-protein kinase Pink1, mitochondrial
CMGC TVAG125560 A2F9N1_TRIV3 9AV7A A2F9N1 15 318 320.0 ANP:401 ATPlike Active DFGin 7.636 16.424 BLAminus -120.42, -177.29 61.53, 69.44 -89.47, 18.08 296.84, 80.84 -66.47, -28.11 in-in in 9.462 Saltbr-in 3.092 HRD-in -77.85, -46.91 69.04, 9.93 in-in-in SNCiii in-in ActLoopNT-in 2.954 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.39, -177.21 APE9-dihe-na 62.4, -175.9 APE8-dihe-in -115.65, 153.97 APE8-rot-in 297.25 APE67-dihe-inflip 82.79, -6.3 -53.46, 134.7 APE12-dist-in 12.695 APE11-dist-in 10.496 APE10-dist-in 6.317 APE9-dist-in 3.013 None None None XRAY 2.1 0.202 0.246 A 328 304 0 0 0 0 [[27, 312]] 1.0 9av7 Trichomonas vaginalis CMGC_TVAG125560_TRIV3 CMGC 2.3e-51 180.8 1 301 301 162 163 164 166 168 56 69 73 141 143 142 144 202 189 184 183 182 181 180 179 178 102 non-specific serine/threonine protein kinase
CAMK AURKBA AUKBA_XENLA 4C2WA Q6DE08 88 356 361.0 ANP:1001 ATPlike Inactive DFGin 5.524 15.79 ABAminus -114.94, -31.28 -113.37, 121.43 -114.18, 23.33 282.52, 84.1 -51.89, -43.92 out-out out 11.268 Saltbr-out 4.973 HRD-in -79.83, -53.41 73.71, 4.05 out-in-in SNCoii in-in ActLoopNT-in 2.893 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.21, 165.55 APE9-dihe-na 112.48, -144.66 APE8-dihe-in -138.33, 133.06 APE8-rot-in 294.04 APE67-dihe-in -66.35, -18.01 -34.41, -59.11 APE12-dist-in 8.359 APE11-dist-in 10.941 APE10-dist-in 5.531 APE9-dist-in 3.561 None TPO248 TPO248 XRAY 1.7 0.158 0.195 A 279 269 0 0 0 0 [[93, 343]] 1.0 4c2w Xenopus laevis CAMK_AURKBA_XENLA CAMK 2.3e-77 265.7 1 256 256 233 234 235 237 239 122 141 145 213 215 214 216 271 259 254 253 252 251 250 249 248 171 Aurora kinase B-A
CAMK AURKBA AUKBA_XENLA 4C2WB Q6DE08 78 355 361.0 ANP:1002 ATPlike Inactive DFGin 5.81 15.787 ABAminus -118.01, -19.02 -130.42, 119.39 -114.99, 28.58 284.95, 75.85 -64.5, -21.38 out-out out 10.763 Saltbr-out 4.74 HRD-in -76.03, -52.74 71.93, -3.36 out-in-in SNCoii in-in ActLoopNT-in 2.919 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.86, 167.53 APE9-dihe-na 123.0, -151.95 APE8-dihe-in -138.83, 132.09 APE8-rot-in 301.48 APE67-dihe-in -63.95, -21.5 -45.73, -54.15 APE12-dist-in 8.042 APE11-dist-in 10.769 APE10-dist-in 5.323 APE9-dist-in 3.606 None TPO248 TPO248 XRAY 1.7 0.158 0.195 B 279 278 0 0 0 0 [[93, 343]] 1.0 4c2w Xenopus laevis CAMK_AURKBA_XENLA CAMK 2.3e-77 265.7 1 256 256 233 234 235 237 239 122 141 145 213 215 214 216 271 259 254 253 252 251 250 249 248 171 Aurora kinase B-A
CMGC ACK2 CSK2A_MAIZE 1DAWA P28523 2 328 332.0 ANP:60340 ATPlike Inactive DFGin 7.479 16.253 BLAminus -105.07, -177.02 59.3, 78.28 -93.62, 17.81 300.8, 85.23 -64.69, -25.71 in-in in 9.044 Saltbr-in 2.614 HRD-in -71.54, -56.91 74.99, 12.33 in-in-out SNCiio in-out ActLoopNT-in 2.653 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -145.67, 164.1 APE9-dihe-na 63.95, 166.03 APE8-dihe-in -78.9, 151.56 APE8-rot-out 157.17 APE67-dihe-in -65.06, -18.37 -51.17, -45.02 APE12-dist-in 12.458 APE11-dist-in 10.113 APE10-dist-in 6.017 APE9-dist-in 3.096 None None None XRAY 2.2 0.223 0.285 A 327 327 0 0 0 0 [[34, 319]] 1.0 1daw Zea mays CMGC_ACK2_MAIZE CMGC 1.7e-65 227.1 1 301 301 169 170 171 173 175 63 76 80 148 150 149 151 209 196 191 190 189 188 187 186 185 109 Casein kinase II subunit alpha
CMGC ACK2 CSK2A_MAIZE 1LP4A P28523 2 328 332.0 ANP:60340 ATPlike Inactive DFGin 7.384 16.437 BLAminus -105.48, -174.19 57.32, 75.68 -95.1, 15.33 299.18, 80.31 -67.7, -16.27 in-in in 8.951 Saltbr-in 2.929 HRD-in -74.21, -49.64 68.44, 10.87 in-in-out SNCiio in-out ActLoopNT-in 2.792 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.52, 168.08 APE9-dihe-na 65.54, 161.64 APE8-dihe-in -72.4, 142.48 APE8-rot-out 152.04 APE67-dihe-in -70.58, -15.11 -42.33, -45.49 APE12-dist-in 12.411 APE11-dist-in 10.041 APE10-dist-in 6.036 APE9-dist-in 3.138 None None None XRAY 1.86 0.207 0.244 A 332 327 0 0 0 0 [[34, 319]] 1.0 1lp4 Zea mays CMGC_ACK2_MAIZE CMGC 1.8e-65 227.0 1 301 301 169 170 171 173 175 63 76 80 148 150 149 151 209 196 191 190 189 188 187 186 185 109 Casein kinase II subunit alpha
OTHER SIRK1 K7VIQ3_MAIZE 5UV4A K7VIQ3 744 1045 1045.0 ANP:1101 ATPlike Pseudo DFGin 4.878 12.802 BLBplus -120.34, 177.7 46.93, 54.84 -91.14, 142.45 62.71, 98.99 59.6, 31.25 out-out out 15.147 Saltbr-out 17.532 HRD-in -68.43, -62.74 80.25, -5.53 out-out-out SNCooo out-out ActLoopNT-out 7.16 ActLoopCT-out nonTYR APEdihe_aaono APEdist_oioo APE10-dihe-na -63.26, -37.61 APE9-dihe-na -61.51, -44.79 APE8-dihe-out -63.05, -40.24 APE8-rot-none 999.0 APE67-dihe-out 86.33, 22.47 -82.94, -6.82 APE12-dist-out 14.657 APE11-dist-in 12.436 APE10-dist-out 11.85 APE9-dist-out 10.422 None None None XRAY 2.3 0.184 0.211 A 311 290 12 0 0 0 [[757, 1042]] 1.0 5uv4 Zea mays OTHER_SIRK1_MAIZE TKL 1.6e-38 138.7 5 265 261 906 907 908 910 912 789 805 809 885 887 886 888 949 935 930 929 928 927 926 925 924 837 Putative leucine-rich repeat protein kinase family protein

Ligand: ANP

Total number of chains: 142
Active chains: 40
Total number of genes: 50
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 71 50.0% 4S32A
DFGin ABAminus 18 12.7% 4C2WA
DFGin BLBplus 18 12.7% 7CTXB
DFGin None 13 9.2% 2VWBA
None None 9 6.3% 4IX5A
DFGin BLBminus 6 4.2% 7CTVA
DFGout None 4 2.8% 4I94A
DFGin BLBtrans 3 2.1% 5W7TA
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CMGC CKA1 CSK21_ARATH 6XX7A Q08467 77 406 409.0 ANP:60401 ATPlike Active DFGin 7.522 16.054 BLAminus -117.69, -174.69 54.04, 89.21 -108.75, 22.96 298.46, 82.8 -72.45, -17.87 in-in in 9.197 Saltbr-in 3.111 HRD-in -78.14, -48.74 65.41, 21.05 in-in-in SNCiii in-in ActLoopNT-in 2.834 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.12, 170.49 APE9-dihe-na 62.76, -171.63 APE8-dihe-in -114.91, 151.01 APE8-rot-in 304.83 APE67-dihe-in -66.49, -17.41 -50.66, -50.22 APE12-dist-in 12.585 APE11-dist-in 10.283 APE10-dist-in 6.188 APE9-dist-in 3.134 None None None XRAY 2.4 0.198 0.246 A 342 330 0 0 0 0 [[110, 395]] 1.0 6xx7 Arabidopsis thaliana CMGC_CKA1_ARATH CMGC 2.6e-65 226.5 1 301 301 245 246 247 249 251 139 152 156 224 226 225 227 285 272 267 266 265 264 263 262 261 185 Casein kinase II subunit alpha-1
CMGC MPK4 MPK4_ARATH 7W5CA Q39024 18 372 376.0 ANP:401 ATPlike Inactive DFGin 6.744 16.225 BLAminus -128.66, -171.29 63.4, 64.26 -92.17, 14.29 279.32, 65.56 -68.22, -18.9 in-in in 9.01 Saltbr-in 3.579 HRD-in -71.53, -46.63 78.29, -8.64 in-in-out SNCiio in-out ActLoopNT-in 2.703 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -115.93, 157.72 APE9-dihe-na -84.69, 1.94 APE8-dihe-in -132.03, 98.21 APE8-rot-out 46.99 APE67-dihe-in -68.07, -19.68 -80.43, -5.49 APE12-dist-out 6.233 APE11-dist-in 10.904 APE10-dist-out 8.979 APE9-dist-out 11.674 None None None XRAY 2.201 0.179 0.225 A 355 355 0 0 0 0 [[44, 329]] 1.0 7w5c Arabidopsis thaliana CMGC_MPK4_ARATH CMGC 1.3e-82 283.5 4 301 298 186 187 188 190 192 72 90 94 166 168 167 169 226 213 208 207 206 205 204 203 202 125 Mitogen-activated protein kinase 4
OTHER BSK8 BSK8_ARATH 4I94A Q9FHD7 40 328 487.0 ANP:60401 ATPlike Pseudo DFGout 11.087 4.579 None -62.85, 129.32 -64.9, -25.87 -61.66, -30.07 297.42, 140.17 -78.36, -1.16 out-out out 12.492 Saltbr-out 11.168 HRD-na-V -138.88, 128.41 -94.79, 85.21 out-out-out SNCooo out-out ActLoopNT-out 8.116 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -112.72, -1.39 APE9-dihe-na -99.73, 174.6 APE8-dihe-in -44.04, 124.87 APE8-rot-na 191.2 APE67-dihe-in -63.8, -11.97 -65.3, -25.56 APE12-dist-in 9.651 APE11-dist-in 13.035 APE10-dist-out 13.738 APE9-dist-out 9.019 None None None XRAY 1.8 0.176 0.218 A 300 289 0 0 0 0 [[64, 311]] 1.0 4i94 Arabidopsis thaliana OTHER_BSK8_ARATH TKL 1.8e-32 119.0 14 264 251 198 199 200 202 204 87 103 107 178 180 179 181 234 222 217 216 215 214 213 212 211 133 Serine/threonine-protein kinase BSK8
OTHER BSK8 BSK8_ARATH 4I94B Q9FHD7 40 328 487.0 ANP:60401 ATPlike Pseudo DFGout 11.167 4.564 None -61.22, 131.83 -70.76, -19.93 -64.01, -28.32 298.7, 142.58 -77.56, -3.78 out-out out 12.61 Saltbr-out 11.562 HRD-na-V -138.23, 125.02 -91.22, 87.17 out-out-out SNCooo out-out ActLoopNT-out 8.121 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iioo APE10-dihe-na -107.48, -5.73 APE9-dihe-na -87.26, 179.81 APE8-dihe-in -41.52, 121.65 APE8-rot-na 191.74 APE67-dihe-in -60.71, -19.43 -60.4, -25.91 APE12-dist-in 9.638 APE11-dist-in 12.966 APE10-dist-out 14.136 APE9-dist-out 9.048 None None None XRAY 1.8 0.176 0.218 B 300 289 0 0 0 0 [[64, 311]] 1.0 4i94 Arabidopsis thaliana OTHER_BSK8_ARATH TKL 1.8e-32 119.0 14 264 251 198 199 200 202 204 87 103 107 178 180 179 181 234 222 217 216 215 214 213 212 211 133 Serine/threonine-protein kinase BSK8
TKL BAK1 BAK1_ARATH 3UIMA Q94F62 272 573 615.0 ANP:1000 ATPlike Inactive DFGin 8.852 13.207 BLAminus -115.13, -165.77 41.37, 88.34 -98.5, 43.81 308.93, 97.2 -70.58, -44.49 in-out in 8.281 Saltbr-out 5.242 HRD-in -79.94, -53.3 85.37, -6.05 out-in-none SNCoin in-none ActLoopNT-in 2.641 ActLoopCT-none nonTYR APEdihe_aaini APEdist_iiii APE10-dihe-na -138.37, 177.14 APE9-dihe-na 106.88, -163.48 APE8-dihe-in -113.09, 162.35 APE8-rot-none 999.0 APE67-dihe-in -50.4, -34.12 -54.05, -40.71 APE12-dist-in 10.912 APE11-dist-in 11.3 APE10-dist-in 7.414 APE9-dist-in 5.319 None SEP290,TPO312,TPO446,TPO449,TPO450,TPO455 SEP290,TPO312,TPO446,TPO449,TPO450,TPO455 XRAY 2.2 0.237 0.277 A 326 297 5 0 0 0 [[288, 565]] 1.0 3uim Arabidopsis thaliana TKL_BAK1_ARATH TKL 5.8e-64 222.2 4 266 263 433 434 435 437 439 317 334 338 413 415 414 416 474 462 457 456 455 454 453 452 451 364 BRASSINOSTEROID INSENSITIVE 1-associated receptor kinase 1
TKL BRI1 BRI1_ARATH 5LPVA O22476 867 1160 1196.0 ANP:1200 ATPlike Active DFGin 5.144 14.999 BLAminus -125.7, -177.27 57.44, 79.7 -100.2, 28.83 289.11, 69.34 -64.8, -27.23 in-in in 8.616 Saltbr-in 2.692 HRD-in -72.39, -48.96 69.78, 4.25 in-in-in SNCiii in-in ActLoopNT-in 2.973 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.4, 152.93 APE9-dihe-na 138.14, -175.87 APE8-dihe-in -122.84, 131.25 APE8-rot-in 310.37 APE67-dihe-inflip 103.25, -12.92 -53.02, 126.73 APE12-dist-in 9.499 APE11-dist-in 11.435 APE10-dist-in 5.667 APE9-dist-in 3.671 T872A TPO1039,SEP1042,SEP1044 TPO1039,SEP1042,SEP1044 XRAY 2.7 0.193 0.233 A 296 285 9 0 0 0 [[882, 1157]] 1.0 5lpv Arabidopsis thaliana TKL_BRI1_ARATH TKL 2e-63 220.4 4 266 263 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL BRI1 BRI1_ARATH 4OH4A O22476 863 1160 1196.0 ANP:61201 ATPlike Active DFGin 5.109 14.621 BLAminus -140.27, -170.9 60.42, 81.58 -96.75, 17.94 285.65, 72.49 -62.14, -24.45 in-in in 8.43 Saltbr-in 2.981 HRD-in -67.48, -45.07 71.79, 0.23 in-in-in SNCiii in-in ActLoopNT-in 2.871 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.28, 137.25 APE9-dihe-na 143.97, 175.71 APE8-dihe-in -113.05, 131.41 APE8-rot-in 300.18 APE67-dihe-inflip 103.6, -22.59 -52.56, 134.8 APE12-dist-in 10.688 APE11-dist-in 12.06 APE10-dist-in 6.328 APE9-dist-in 4.124 None TPO1039,SEP1042,SEP1044,SEP1060 TPO1039,SEP1042,SEP1044,SEP1060 XRAY 2.25 0.203 0.236 A 333 292 6 0 0 0 [[882, 1157]] 1.0 4oh4 Arabidopsis thaliana TKL_BRI1_ARATH TKL 3e-63 219.8 4 266 263 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL BRI1 BRI1_ARATH 4OH4B O22476 867 1160 1196.0 ANP:61201 ATPlike Active DFGin 5.028 14.866 BLAminus -128.92, -179.57 66.05, 81.1 -97.08, 13.19 285.07, 69.22 -52.61, -27.46 in-in in 8.604 Saltbr-in 2.585 HRD-in -68.96, -46.37 73.67, -10.15 in-in-in SNCiii in-in ActLoopNT-in 2.87 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.43, 142.85 APE9-dihe-na 162.33, 170.81 APE8-dihe-in -132.62, 128.73 APE8-rot-in 297.7 APE67-dihe-inflip 104.71, -30.59 -48.41, 132.44 APE12-dist-in 9.471 APE11-dist-in 10.311 APE10-dist-in 5.146 APE9-dist-in 4.053 None TPO1039,SEP1042,SEP1044,SEP1060 TPO1039,SEP1042,SEP1044,SEP1060 XRAY 2.25 0.203 0.236 B 333 283 11 0 0 0 [[882, 1157]] 1.0 4oh4 Arabidopsis thaliana TKL_BRI1_ARATH TKL 3e-63 219.8 4 266 263 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL BRI1 BRI1_ARATH 4Q5JA O22476 863 1160 1196.0 ANP:61201 ATPlike Active DFGin 5.066 14.74 BLAminus -137.9, 174.67 63.19, 85.3 -100.14, 20.42 284.87, 74.71 -62.5, -33.31 in-in in 8.354 Saltbr-in 3.257 HRD-in -68.22, -43.45 65.77, 3.93 in-in-in SNCiii in-in ActLoopNT-in 2.662 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.48, 139.01 APE9-dihe-na 175.24, 173.84 APE8-dihe-in -115.42, 129.74 APE8-rot-in 289.59 APE67-dihe-inflip 96.87, -1.52 -53.59, 124.31 APE12-dist-in 10.51 APE11-dist-in 12.065 APE10-dist-in 6.236 APE9-dist-in 4.467 None TPO1039,SEP1042,SEP1044,SEP1060 MSE925,MSE928,MSE959,MSE1010,MSE1030,MSE1034,MSE1037,TPO1039,SEP1042,SEP1044,SEP1060,MSE1117,MSE1148,MSE1152,MSE1154 XRAY 2.772 0.203 0.259 A 341 287 11 0 0 0 [[882, 1157]] 1.0 4q5j Arabidopsis thaliana TKL_BRI1_ARATH TKL 3.2e-63 219.7 4 266 263 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL BRI1 BRI1_ARATH 4Q5JB O22476 867 1160 1196.0 ANP:61201 ATPlike Active DFGin 5.259 14.8 BLAminus -126.47, -178.56 58.45, 93.89 -112.89, 22.9 283.23, 71.66 -57.4, -19.56 in-in in 8.732 Saltbr-in 3.184 HRD-in -81.55, -35.96 67.72, -5.15 in-in-in SNCiii in-in ActLoopNT-in 2.775 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -167.14, 134.16 APE9-dihe-na 157.62, 164.27 APE8-dihe-in -126.08, 123.8 APE8-rot-in 304.99 APE67-dihe-inflip 120.44, -28.11 -46.98, 122.06 APE12-dist-in 9.403 APE11-dist-in 10.636 APE10-dist-in 5.512 APE9-dist-in 4.081 None TPO1039,SEP1042,SEP1044,SEP1060 MSE925,MSE928,MSE959,MSE1010,MSE1030,MSE1034,MSE1037,TPO1039,SEP1042,SEP1044,SEP1060,MSE1117,MSE1148,MSE1152,MSE1154 XRAY 2.772 0.203 0.259 B 341 283 11 0 0 0 [[882, 1157]] 1.0 4q5j Arabidopsis thaliana TKL_BRI1_ARATH TKL 3.2e-63 219.7 4 266 263 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL CARK1 CARK1_ARATH 5XD6A Q9LUT0 50 350 364.0 ANP:61000 ATPlike Inactive DFGin 5.287 13.989 None -82.23, -179.6 -66.2, 154.72 -113.7, 177.91 45.1, 88.76 -91.38, 112.57 out-na out 13.41 Saltbr-na 13.476 HRD-in -67.99, -48.34 77.3, -6.84 na-out-none SNCaon out-none ActLoopNT-out 8.296 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 12.83 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.898 0.218 0.251 A 305 278 23 0 0 17 [[67, 347]] 1.0 5xd6 Arabidopsis thaliana TKL_CARK1_ARATH TKL 9e-61 211.7 4 266 263 216 217 218 220 222 97 112 116 196 198 197 199 258 246 241 240 239 238 237 236 235 142 Protein CYTOSOLIC ABA RECEPTOR KINASE 1
TKL CARK1 CARK1_ARATH 5XD6B Q9LUT0 50 350 364.0 ANP:61000 ATPlike Inactive DFGin 5.63 13.93 None -77.44, -177.16 -70.67, 157.78 -117.63, 177.11 50.67, 89.87 -85.72, 109.22 out-na out 13.676 Saltbr-na 14.086 HRD-in -75.16, -46.81 74.28, -9.17 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -2.12 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.898 0.218 0.251 B 305 282 19 0 0 19 [[67, 347]] 1.0 5xd6 Arabidopsis thaliana TKL_CARK1_ARATH TKL 9e-61 211.7 4 266 263 216 217 218 220 222 97 112 116 196 198 197 199 258 246 241 240 239 238 237 236 235 142 Protein CYTOSOLIC ABA RECEPTOR KINASE 1
TKL SOBIR1 SBIR1_ARATH 7CTVA Q9SKB2 326 639 641.0 ANP:60702 ATPlike Inactive DFGin 6.661 13.885 BLBminus -141.13, -179.6 54.72, 58.77 -66.01, 150.7 286.65, 72.17 -81.72, 124.12 out-none out 15.112 Saltbr-none 999.0 HRD-out -87.3, 102.63 -86.62, 6.82 none-out-out SNCnoo out-out ActLoopNT-out 9.521 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -76.63, -5.1 APE9-dihe-na 65.07, 35.87 APE8-dihe-out -126.08, 24.51 APE8-rot-out 59.01 APE67-dihe-in -54.76, -18.48 -67.58, -32.17 APE12-dist-out 20.762 APE11-dist-out 20.491 APE10-dist-out 17.179 APE9-dist-out 13.97 D489A None None XRAY 2.886 0.218 0.239 A 336 297 17 0 0 0 [[343, 638]] 1.0 7ctv Arabidopsis thaliana TKL_SOBIR1_ARATH TKL 8.4e-57 198.7 4 266 263 506 507 508 510 512 377 407 411 486 488 487 489 548 536 531 530 529 528 527 526 525 437 Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1
TKL SOBIR1 SBIR1_ARATH 7CTVB Q9SKB2 326 640 641.0 ANP:60702 ATPlike Inactive DFGin 6.421 13.87 BLBminus -144.86, -178.02 49.22, 64.23 -62.65, 147.84 294.25, 70.22 -69.54, 92.84 out-none out 15.253 Saltbr-none 999.0 HRD-out -90.69, 89.36 -71.79, -21.49 none-out-out SNCnoo out-out ActLoopNT-out 9.121 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -77.41, -5.23 APE9-dihe-na 69.76, 25.67 APE8-dihe-out -112.95, 17.98 APE8-rot-out 72.42 APE67-dihe-in -62.91, -23.09 -65.66, -31.24 APE12-dist-out 20.132 APE11-dist-out 19.759 APE10-dist-out 16.431 APE9-dist-out 13.633 D489A None None XRAY 2.886 0.218 0.239 B 336 292 23 0 0 0 [[343, 638]] 1.0 7ctv Arabidopsis thaliana TKL_SOBIR1_ARATH TKL 8.4e-57 198.7 4 266 263 506 507 508 510 512 377 407 411 486 488 487 489 548 536 531 530 529 528 527 526 525 437 Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1
TKL SOBIR1 SBIR1_ARATH 7CTXA Q9SKB2 326 639 641.0 ANP:60701 ATPlike Inactive DFGin 5.925 13.958 BLBplus -138.51, 171.55 56.64, 47.79 -120.23, 164.88 60.27, 92.94 88.0, -43.52 out-out out 14.426 Saltbr-out 14.62 HRD-in -69.62, -53.51 75.07, -7.08 out-out-out SNCooo out-out ActLoopNT-out 8.647 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -78.29, -6.92 APE9-dihe-na 74.92, 27.29 APE8-dihe-out -123.12, 22.17 APE8-rot-out 54.06 APE67-dihe-in -63.92, -13.63 -66.83, -19.82 APE12-dist-out 21.872 APE11-dist-out 21.46 APE10-dist-out 18.282 APE9-dist-out 14.121 None None None XRAY 2.907 0.226 0.243 A 323 293 8 0 0 0 [[343, 638]] 1.0 7ctx Arabidopsis thaliana TKL_SOBIR1_ARATH TKL 1.3e-59 207.9 4 266 263 506 507 508 510 512 377 407 411 486 488 487 489 548 536 531 530 529 528 527 526 525 437 Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1
TKL SOBIR1 SBIR1_ARATH 7CTXB Q9SKB2 326 640 641.0 ANP:60701 ATPlike Inactive DFGin 5.875 13.993 BLBplus -137.44, 176.16 58.26, 44.88 -125.18, 162.12 65.68, 87.66 87.14, -0.96 out-out out 14.063 Saltbr-out 13.631 HRD-in -66.8, -55.86 75.55, -4.98 out-out-out SNCooo out-out ActLoopNT-out 8.85 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -76.44, -5.32 APE9-dihe-na 71.29, 28.46 APE8-dihe-out -125.93, 28.87 APE8-rot-out 53.38 APE67-dihe-in -62.75, -12.89 -73.08, -23.74 APE12-dist-out 21.618 APE11-dist-out 21.328 APE10-dist-out 18.191 APE9-dist-out 14.316 None None None XRAY 2.907 0.226 0.243 B 323 297 5 0 0 0 [[343, 638]] 1.0 7ctx Arabidopsis thaliana TKL_SOBIR1_ARATH TKL 1.3e-59 207.9 4 266 263 506 507 508 510 512 377 407 411 486 488 487 489 548 536 531 530 529 528 527 526 525 437 Leucine-rich repeat receptor-like serine/threonine/tyrosine-protein kinase SOBIR1
AGC PRKACA KAPCA_BOVIN 9DW5G P00517 13 351 351.0 ANP:403 ATPlike Inactive DFGin 7.334 15.877 BLAminus -126.22, -169.89 60.75, 61.77 -87.02, 21.16 273.51, 93.96 -63.0, -33.74 out-none out 10.252 Saltbr-none 999.0 HRD-in -80.85, -56.62 73.43, -6.68 none-in-in SNCnii in-in ActLoopNT-in 2.782 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -167.11, -173.97 APE9-dihe-na 106.0, -157.25 APE8-dihe-in -108.29, 136.12 APE8-rot-in 326.0 APE67-dihe-in -63.46, -43.06 -59.57, -33.75 APE12-dist-in 9.113 APE11-dist-in 11.955 APE10-dist-in 6.81 APE9-dist-in 4.563 None TPO198 TPO198 EM 3.8 999.0 999.0 G 351 330 0 0 0 0 [[44, 298]] 1.0 9dw5 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 9DW8G P00517 15 329 351.0 ANP:403 ATPlike None DFGin 6.07 14.235 BLAminus -131.43, -174.72 59.27, 66.66 -86.28, 33.46 293.19, 93.28 -61.23, -49.05 in-none in 9.911 Saltbr-none 999.0 HRD-in -98.32, -49.71 57.42, 11.15 none-in-in SNCnii in-in ActLoopNT-in 2.961 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -168.06, 160.73 APE9-dihe-na 123.3, -175.7 APE8-dihe-in -89.52, 132.72 APE8-rot-in 298.44 APE67-dihe-in -69.93, -27.98 -56.75, -38.6 APE12-dist-in 8.7 APE11-dist-in 11.593 APE10-dist-in 6.411 APE9-dist-in 4.803 None TPO198 TPO198 EM 3.5 999.0 999.0 G 351 309 0 0 0 0 [[44, 298]] 1.0 9dw8 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 9DW7G P00517 13 351 351.0 ANP:403 ATPlike Inactive None 999.0 999.0 None -155.4, -162.2 59.11, 63.62 -70.57, 12.19 999.0, 999.0 -65.51, -34.83 out-none out 10.971 Saltbr-none 999.0 HRD-in -65.14, -55.26 50.7, 27.28 none-in-out SNCnio in-out ActLoopNT-in 2.575 ActLoopCT-out nonTYR APEdihe_aaini APEdist_iiio APE10-dihe-na -166.96, 170.69 APE9-dihe-na 108.98, -156.8 APE8-dihe-in -102.79, 139.06 APE8-rot-none 999.0 APE67-dihe-in -58.63, -28.81 -67.98, -6.96 APE12-dist-in 9.228 APE11-dist-in 10.267 APE10-dist-in 6.438 APE9-dist-out 6.202 None None None EM 6.0 999.0 999.0 G 351 339 0 0 0 0 [[44, 298]] 1.0 9dw7 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
TYR LET23 LET23_CAEEL 5WNOA P24348 876 1190 1323.0 ANP:1201 ATPlike Inactive DFGin 6.247 12.877 BLBplus -129.17, 177.47 55.99, 43.49 -103.44, 159.44 53.09, 86.5 67.88, 29.06 out-out out 14.465 Saltbr-out 14.517 HRD-in -74.41, -38.75 70.96, -11.0 out-out-out SNCooo out-out ActLoopNT-out 7.638 ActLoopCT-out TYR APEdihe_nooai APEdist_aaao APE10-dihe-none 999.0, -139.66 APE9-dihe-out -62.23, -13.83 APE8-dihe-out -67.85, 10.53 APE8-rot-na 999.0 APE67-dihe-in -61.61, -23.35 -63.66, -29.42 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.694 APE9-dist-out 10.859 None None None XRAY 2.386 0.217 0.247 A 330 302 13 0 0 12 [[885, 1143]] 1.0 5wno Caenorhabditis elegans TYR_LET23_CAEEL TYR 1.6e-78 269.6 2 260 259 1027 1028 1029 1031 1033 919 934 938 1007 1009 1008 1010 1069 1057 1052 1051 1050 1049 1048 1047 1046 964 Receptor tyrosine-protein kinase let-23
CMGC CK2 Q5KF69_CRYD1 6ISEA Q5KF69 5 331 336.0 ANP:403 ATPlike Active DFGin 7.339 16.208 BLAminus -129.3, -170.99 44.36, 71.77 -91.05, 22.67 299.01, 82.29 -66.02, -23.99 in-in in 9.482 Saltbr-in 3.336 HRD-in -65.48, -54.09 76.82, 9.27 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.0, -19.23 APE9-dihe-na -99.69, -172.72 APE8-dihe-in -80.09, 147.5 APE8-rot-in 301.93 APE67-dihe-in -61.24, -16.59 -47.75, -58.81 APE12-dist-in 12.687 APE11-dist-in 10.631 APE10-dist-in 6.144 APE9-dist-in 3.609 None None None XRAY 2.8 0.198 0.23 A 338 327 0 0 0 0 [[38, 323]] 1.0 6ise Cryptococcus deneoformans CMGC_CK2_CRYD1 CMGC 6e-64 222.0 1 301 301 173 174 175 177 179 67 80 84 152 154 153 155 213 200 195 194 193 192 191 190 189 113 Casein kinase II subunit alpha
CMGC CK2 Q5KF69_CRYD1 6ISEB Q5KF69 5 331 336.0 ANP:403 ATPlike Active DFGin 7.308 16.238 BLAminus -133.11, -171.48 44.36, 73.35 -91.98, 23.51 299.28, 79.86 -68.68, -21.78 in-in in 9.591 Saltbr-in 3.496 HRD-in -67.7, -51.8 75.87, 7.92 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.38, 168.0 APE9-dihe-na 74.76, -173.48 APE8-dihe-in -110.86, 148.66 APE8-rot-in 271.82 APE67-dihe-in -65.62, -23.31 -54.68, -45.78 APE12-dist-in 12.576 APE11-dist-in 10.311 APE10-dist-in 6.266 APE9-dist-in 3.367 None None None XRAY 2.8 0.198 0.23 B 338 327 0 0 0 0 [[38, 323]] 1.0 6ise Cryptococcus deneoformans CMGC_CK2_CRYD1 CMGC 6e-64 222.0 1 301 301 173 174 175 177 179 67 80 84 152 154 153 155 213 200 195 194 193 192 191 190 189 113 Casein kinase II subunit alpha
CMGC CKA1 J9VNH4_CRYN9 6KO6B J9VNH4 5 334 338.0 ANP:401 ATPlike Active DFGin 7.298 16.236 BLAminus -115.02, -165.9 52.87, 72.55 -94.97, 21.12 299.2, 77.23 -71.99, -18.35 in-in in 9.324 Saltbr-in 3.151 HRD-in -64.53, -49.64 63.27, 19.41 in-in-in SNCiii in-in ActLoopNT-in 3.055 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.45, 156.98 APE9-dihe-na 76.83, -179.82 APE8-dihe-in -92.38, 159.35 APE8-rot-in 277.62 APE67-dihe-in -71.62, -13.46 -53.06, -52.26 APE12-dist-in 12.792 APE11-dist-in 10.474 APE10-dist-in 6.177 APE9-dist-in 3.249 None None None XRAY 2.4 0.238 0.268 B 338 330 0 0 0 0 [[38, 323]] 1.0 6ko6 Cryptococcus neoformans CMGC_CKA1_CRYN9 CMGC 6e-64 222.0 1 301 301 173 174 175 177 179 67 80 84 152 154 153 155 213 200 195 194 193 192 191 190 189 113 Casein kinase II subunit alpha
CAMK CDPK1 A3FQ16_CRYPI 3IGOA A3FQ16 70 537 538.0 ANP:60610 ATPlike Inactive DFGin 6.707 13.465 BLBplus -121.25, 174.97 67.47, 60.04 -154.02, 168.86 59.26, 84.09 92.58, -14.73 out-out out 14.209 Saltbr-out 13.065 HRD-in -63.43, -55.21 83.61, -21.71 out-out-out SNCooo out-out ActLoopNT-out 9.03 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 153.6 APE8-rot-out 169.15 APE67-dihe-in -51.84, -35.84 -53.96, -31.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.25 0.205 0.258 A 486 445 8 0 0 7 [[76, 332]] 1.0 3igo Cryptosporidium parvum CAMK_CDPK1_CRYPI CAMK 3.4e-90 308.1 1 256 256 218 219 220 222 224 105 123 127 195 197 196 198 256 245 240 239 238 237 236 235 234 153 non-specific serine/threonine protein kinase
CAMK CDPK3 Q5CS01_CRYPI 3LIJA Q5CS01 42 516 523.0 ANP:60522 ATPlike Inactive DFGin 7.034 14.655 BLAminus -127.46, 177.5 59.13, 85.54 -100.29, 19.94 282.89, 79.61 -59.37, -32.9 out-out out 10.177 Saltbr-out 5.256 HRD-in -74.61, -49.83 71.32, -4.41 out-in-in SNCoii in-in ActLoopNT-in 2.936 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.48, 149.72 APE9-dihe-na 141.55, -153.66 APE8-dihe-in -128.1, 132.61 APE8-rot-in 307.4 APE67-dihe-in -65.62, -35.53 -34.47, -55.78 APE12-dist-in 8.691 APE11-dist-in 11.66 APE10-dist-in 5.782 APE9-dist-in 3.569 None None None XRAY 1.9 0.203 0.229 A 494 461 8 0 0 0 [[62, 318]] 1.0 3lij Cryptosporidium parvum CAMK_CDPK3_CRYPI CAMK 2.7e-91 311.6 1 256 256 204 205 206 208 210 91 109 113 181 183 182 184 242 231 226 225 224 223 222 221 220 139 Calcium-dependent protein kinase 1
CAMK CDPK4-2 Q5CZ29_CRYPI 3HKOA Q5CZ29 126 452 824.0 ANP:60329 ATPlike Inactive DFGin 5.952 15.583 ABAminus -120.43, 2.55 -135.28, 127.73 -128.94, 23.59 286.29, 84.57 -62.1, -26.95 out-out out 10.111 Saltbr-out 4.434 HRD-in -76.09, -50.74 72.63, 1.72 out-in-out SNCoio in-out ActLoopNT-in 2.773 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, -104.24 APE9-dihe-na 126.39, -179.13 APE8-dihe-in -75.92, 124.68 APE8-rot-in 280.37 APE67-dihe-in -53.45, -34.89 -49.78, -39.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 8.406 APE9-dist-in 3.722 None None None XRAY 1.8 0.204 0.246 A 345 314 13 0 0 8 [[135, 237], [261, 441]] 2.0 3hko Cryptosporidium parvum CAMK_CDPK4-2_CRYPI CAMK 1.5e-19 241.1 1 89 250 319 320 321 323 325 164 185 189 297 299 298 300 365 351 346 345 344 343 342 341 340 215 non-specific serine/threonine protein kinase
CMGC BSK JNK_DROME 5AWMA P92208 7 362 372.0 ANP:401 ATPlike Inactive DFGin 3.968 14.304 ABAminus -88.58, -21.58 -138.57, 174.5 -114.07, -2.87 300.82, 95.37 86.6, -153.47 out-out out 10.429 Saltbr-out 5.258 HRD-in -75.17, -58.38 75.26, -11.27 out-out-out SNCooo out-out ActLoopNT-out 6.357 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -11.69 APE9-dihe-na -122.62, 142.03 APE8-dihe-in -71.85, 116.06 APE8-rot-in 300.48 APE67-dihe-in -65.6, -18.22 -112.19, 0.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.382 APE9-dist-out 11.166 None None None XRAY 1.79 0.179 0.22 A 394 345 9 0 0 3 [[24, 320]] 1.0 5awm Drosophila melanogaster CMGC_BSK_DROME CMGC 8.1e-82 280.8 1 301 301 166 167 168 170 172 53 71 75 146 148 147 149 205 193 188 187 186 185 184 183 182 107 Stress-activated protein kinase JNK
STE DSOR1 DSOR1_DROME 8BW9C Q24324 81 384 396.0 ANP:60401,QOM:60402 ATPlike,Type3 Inactive DFGin 5.477 14.249 BLBplus -159.47, 168.77 62.79, 56.43 -107.18, 135.07 48.27, 89.36 -64.21, 107.83 out-out out 15.559 Saltbr-out 19.84 HRD-in -58.37, -64.17 71.81, -9.38 out-out-out SNCooo out-out ActLoopNT-out 8.849 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -115.48, -57.78 APE9-dihe-na 75.76, 170.55 APE8-dihe-out -89.06, -0.85 APE8-rot-out 170.28 APE67-dihe-out -125.12, 142.75 -125.31, 123.31 APE12-dist-out 17.384 APE11-dist-out 19.526 APE10-dist-out 21.999 APE9-dist-out 14.644 None None None EM 3.32 999.0 999.0 C 396 280 24 0 0 0 [[87, 364]] 1.0 8bw9 Drosophila melanogaster STE_DSOR1_DROME STE 2.5e-90 308.3 2 256 255 226 227 228 230 232 116 133 137 206 208 207 209 264 252 247 246 245 244 243 242 241 163 Dual specificity mitogen-activated protein kinase kinase dSOR1
TYR PTK2 FAK1_CHICK 2J0LA Q00944 411 686 1053.0 ANP:1689 ATPlike Inactive DFGin 7.042 15.595 BLAminus -124.12, -151.88 51.86, 82.15 -108.03, 32.91 286.36, 85.03 -71.96, -36.63 in-in in 7.824 Saltbr-in 2.777 HRD-in -78.92, -53.9 78.76, -8.92 in-in-out SNCiio in-out ActLoopNT-in 2.956 ActLoopCT-out TYR APEdihe_iiiai APEdist_aaao APE10-dihe-in -71.98, 100.38 APE9-dihe-in -65.3, 130.79 APE8-dihe-in -75.31, 71.06 APE8-rot-na 28.66 APE67-dihe-in -69.29, -16.82 -49.9, -41.21 APE12-dist-na 11.387 APE11-dist-na 10.256 APE10-dist-na 13.533 APE9-dist-out 8.279 None PTR576,PTR577 PTR576,PTR577 XRAY 2.3 0.217 0.263 A 276 276 0 0 0 0 [[422, 678]] 1.0 2j0l Gallus gallus TYR_PTK2_CHICK TYR 2.6e-93 318.0 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 6TY4A Q00944 34 686 1053.0 ANP:702 ATPlike Active DFGin 7.546 15.951 BLAminus -124.05, -151.88 51.86, 82.13 -107.99, 32.9 286.39, 85.0 -72.01, -36.58 in-in in 8.437 Saltbr-in 3.562 HRD-in -70.16, -30.0 74.19, -18.38 in-in-in SNCiii in-in ActLoopNT-in 2.815 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.31, 66.54 APE9-dihe-in -63.31, 139.75 APE8-dihe-in -64.41, 127.23 APE8-rot-na 22.65 APE67-dihe-in -56.19, -42.03 -70.19, -41.73 APE12-dist-na 11.489 APE11-dist-na 10.184 APE10-dist-na 13.636 APE9-dist-in 7.205 None None None EM 5.96 999.0 999.0 A 658 621 0 0 0 0 [[422, 678]] 1.0 6ty4 Gallus gallus TYR_PTK2_CHICK TYR 1.5e-91 312.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_CHICK 6TY4B Q00944 34 686 1053.0 ANP:702 ATPlike Active DFGin 7.546 15.95 BLAminus -124.03, -151.9 51.82, 82.14 -107.99, 32.89 286.33, 85.06 -71.97, -36.56 in-in in 8.436 Saltbr-in 3.562 HRD-in -70.15, -30.0 74.26, -18.38 in-in-in SNCiii in-in ActLoopNT-in 2.815 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -86.3, 66.56 APE9-dihe-in -63.34, 139.79 APE8-dihe-in -64.42, 127.23 APE8-rot-na 22.65 APE67-dihe-in -56.21, -42.01 -70.19, -41.71 APE12-dist-na 11.489 APE11-dist-na 10.183 APE10-dist-na 13.636 APE9-dist-in 7.205 None None None EM 5.96 999.0 999.0 B 658 621 0 0 0 0 [[422, 678]] 1.0 6ty4 Gallus gallus TYR_PTK2_CHICK TYR 1.5e-91 312.7 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
OTHER LPL0262 Q5WZW9_LEGPL 5CKWA Q5WZW9 15 404 961.0 ANP:60501 ATPlike Active DFGin 5.948 12.719 BLAminus -133.44, 169.43 70.28, 94.79 -117.83, 12.87 299.33, 117.8 -55.88, -8.97 in-in in 6.71 Saltbr-in 2.716 HRD-na-Q -80.53, -48.66 73.11, 5.26 in-in-in SNCiii in-in ActLoopNT-in 2.927 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -69.26, -22.18 APE9-dihe-na -101.55, 179.41 APE8-dihe-in -117.11, 122.15 APE8-rot-in 302.21 APE67-dihe-in -64.67, -9.61 -57.44, -37.84 APE12-dist-in 11.762 APE11-dist-in 9.709 APE10-dist-in 4.647 APE9-dist-in 3.347 None None None XRAY 2.49 0.207 0.258 A 451 378 5 0 0 0 [[75, 309]] 1.0 5ckw Legionella pneumophila OTHER_LPL0262_LEGPL NEK 4.8e-15 62.8 10 222 213 212 213 214 216 218 104 119 123 192 194 193 195 249 237 232 231 230 229 228 227 226 146 non-specific serine/threonine protein kinase
OTHER LPL0262 Q5WZW9_LEGPL 5CKWB Q5WZW9 1 404 961.0 ANP:60501 ATPlike Active DFGin 6.189 12.674 BLAminus -144.06, 165.73 65.65, 85.18 -109.61, 21.73 306.46, 113.14 -57.87, -17.2 in-in in 6.769 Saltbr-in 2.882 HRD-na-Q -82.05, -45.94 73.24, -7.24 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -76.56, -19.65 APE9-dihe-na -103.71, -175.8 APE8-dihe-in -130.62, 116.65 APE8-rot-in 293.03 APE67-dihe-in -65.48, -28.87 -48.06, -39.07 APE12-dist-in 11.529 APE11-dist-in 9.586 APE10-dist-in 4.483 APE9-dist-in 3.458 None None None XRAY 2.49 0.207 0.258 B 451 399 5 0 0 0 [[75, 309]] 1.0 5ckw Legionella pneumophila OTHER_LPL0262_LEGPL NEK 4.8e-15 62.8 10 222 213 212 213 214 216 218 104 119 123 192 194 193 195 249 237 232 231 230 229 228 227 226 146 non-specific serine/threonine protein kinase
CMGC MAPK A0A3Q8ITZ9_LEIDO 4QNYA A0A3Q8ITZ9 4 350 408.0 ANP:402 ATPlike Inactive DFGin 6.165 14.704 BLAminus -127.76, -174.94 61.93, 78.26 -95.74, 34.98 293.98, 91.09 -76.44, -18.02 in-in in 9.348 Saltbr-in 2.729 HRD-in -68.82, -45.36 71.54, -13.83 in-in-out SNCiio in-out ActLoopNT-in 2.741 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oooo APE10-dihe-na -132.18, 155.62 APE9-dihe-na -94.67, -21.05 APE8-dihe-in -141.24, 100.95 APE8-rot-na 183.02 APE67-dihe-in -68.06, -10.3 -112.98, 4.12 APE12-dist-out 16.023 APE11-dist-out 14.67 APE10-dist-out 11.69 APE9-dist-out 12.567 None None None XRAY 2.257 0.237 0.285 A 354 333 3 0 0 3 [[21, 310]] 1.0 4qny Leishmania donovani CMGC_MAPK_LEIDO CMGC 5.8e-75 258.3 3 301 299 166 167 168 170 172 51 70 74 146 148 147 149 207 194 189 188 187 186 185 184 183 105 Mitogen activated protein kinase, putative
CMGC MAPK A0A3Q8ITZ9_LEIDO 4QNYB A0A3Q8ITZ9 4 350 408.0 ANP:403 ATPlike Inactive DFGin 6.138 14.789 BLAminus -126.8, -176.12 61.38, 78.86 -95.33, 36.88 294.2, 91.77 -77.29, -21.88 in-in in 9.453 Saltbr-in 2.831 HRD-in -69.33, -48.45 68.04, -9.32 in-in-out SNCiio in-out ActLoopNT-in 2.581 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oooo APE10-dihe-na -133.75, 152.71 APE9-dihe-na -90.5, -19.94 APE8-dihe-in -141.35, 99.54 APE8-rot-na 186.55 APE67-dihe-in -67.94, -11.27 -112.59, 3.99 APE12-dist-out 16.148 APE11-dist-out 14.749 APE10-dist-out 11.684 APE9-dist-out 12.642 None None None XRAY 2.257 0.237 0.285 B 354 339 2 0 0 2 [[21, 310]] 1.0 4qny Leishmania donovani CMGC_MAPK_LEIDO CMGC 5.8e-75 258.3 3 301 299 166 167 168 170 172 51 70 74 146 148 147 149 207 194 189 188 187 186 185 184 183 105 Mitogen activated protein kinase, putative
TKL LYK3 LYK3_MEDTR 9GFZA Q6UD73 302 596 620.0 ANP:601 ATPlike Inactive DFGin 5.896 16.319 BLBtrans -112.0, 159.57 61.3, 42.0 -77.09, 135.77 153.85, 71.13 82.14, -2.66 out-out out 14.795 Saltbr-out 16.343 HRD-in -69.33, -37.57 70.07, -2.36 out-out-out SNCooo out-out ActLoopNT-out 6.107 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -140.09, 130.62 APE9-dihe-na 119.67, 164.52 APE8-dihe-in -118.67, 135.65 APE8-rot-in 301.27 APE67-dihe-inflip 89.4, -18.92 -56.77, 138.93 APE12-dist-out 14.646 APE11-dist-in 13.079 APE10-dist-out 9.194 APE9-dist-in 4.309 D459N None None XRAY 2.5 0.211 0.257 A 296 288 7 0 0 4 [[321, 594]] 1.0 9gfz Medicago truncatula TKL_LYK3_MEDTR TKL 3.5e-59 206.5 3 264 262 458 459 460 462 464 349 362 366 438 440 439 441 499 487 482 481 480 479 478 477 476 391 LysM domain receptor-like kinase 3
TKL LYR4 G7K7K0_MEDTR 8PS7B G7K7K0 340 636 660.0 ANP:703 ATPlike Pseudo DFGin 7.768 15.066 BLBminus -155.57, -174.44 55.36, 56.3 -70.81, 152.24 289.97, 66.8 93.85, 156.74 out-out out 15.961 Saltbr-out 14.036 HRD-in -57.6, -55.05 79.6, -10.79 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -72.46, -42.72 APE9-dihe-na -56.2, -52.66 APE8-dihe-out -56.27, -29.69 APE8-rot-out 59.05 APE67-dihe-in -100.31, -14.89 -66.25, -40.12 APE12-dist-in 9.702 APE11-dist-in 13.647 APE10-dist-out 15.243 APE9-dist-out 9.612 None None None XRAY 2.1 0.225 0.269 B 297 274 23 0 0 12 [[360, 633]] 1.0 8ps7 Medicago truncatula TKL_LYR4_MEDTR TKL 4.9e-53 186.3 13 266 254 493 494 495 497 499 379 388 392 473 475 474 476 538 526 521 520 519 518 517 516 515 418 LysM-domain receptor-like kinase
TKL LYR4 G7K7K0_MEDTR 8PS7A G7K7K0 340 636 660.0 ANP:704 ATPlike Pseudo DFGin 7.344 12.491 None -132.7, -71.23 -80.99, 65.77 -101.31, -4.53 43.9, 75.68 -166.17, 141.69 out-out out 12.664 Saltbr-out 13.161 HRD-in -67.54, -63.16 83.85, -10.66 out-out-out SNCooo out-out ActLoopNT-out 9.632 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -64.12, -49.62 APE9-dihe-na -62.67, -34.57 APE8-dihe-out -58.19, -50.78 APE8-rot-in 276.77 APE67-dihe-in -82.12, -28.85 -67.98, -32.83 APE12-dist-out 14.247 APE11-dist-out 19.231 APE10-dist-out 20.4 APE9-dist-out 9.296 None None None XRAY 2.1 0.225 0.269 A 297 279 18 0 0 0 [[360, 633]] 1.0 8ps7 Medicago truncatula TKL_LYR4_MEDTR TKL 4.9e-53 186.3 13 266 254 493 494 495 497 499 379 388 392 473 475 474 476 538 526 521 520 519 518 517 516 515 418 LysM-domain receptor-like kinase
OTHER BUD32 KAE1B_METJA 2VWBA Q58530 1 530 535.0 ANP:1531 Allosteric Inactive DFGin 6.844 17.132 None -120.64, -3.56 -136.03, 137.71 -148.58, 37.82 232.34, 113.93 -66.32, -14.47 in-in in 7.975 Saltbr-in 2.728 HRD-out -83.04, 140.14 -107.29, 16.57 in-in-na SNCiia in-na ActLoopNT-in 2.916 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -66.96, -33.04 APE9-dihe-na -68.59, -42.86 APE8-dihe-na -73.15, -19.01 APE8-rot-na 294.55 APE67-dihe-na -59.99, -36.61 -63.88, -52.94 APE12-dist-na 17.018 APE11-dist-na 12.319 APE10-dist-na 14.969 APE9-dist-na 11.662 None None None XRAY 3.05 0.224 0.301 A 535 519 4 0 0 0 [[334, 534]] 1.0 2vwb Methanocaldococcus jannaschii OTHER_BUD32_METJA TP53RK 8.5e-45 159.9 6 218 213 466 467 468 470 472 360 384 388 448 450 449 451 483 489 484 483 482 481 480 479 478 414 Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
OTHER BUD32 KAE1B_METJA 2VWBB Q58530 1 532 535.0 ANP:1533 Allosteric Inactive DFGin 6.58 16.716 None -128.01, -5.24 -139.71, 160.08 -157.9, 25.33 238.13, 113.59 -41.68, -37.13 in-in in 7.846 Saltbr-in 3.175 HRD-out -90.81, 128.03 -91.65, 20.67 in-in-na SNCiia in-na ActLoopNT-in 2.657 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -74.1, -29.36 APE9-dihe-na -76.07, -42.12 APE8-dihe-na -69.9, -15.57 APE8-rot-na 312.74 APE67-dihe-na -42.13, -37.17 -74.66, -63.72 APE12-dist-na 16.649 APE11-dist-na 12.112 APE10-dist-na 14.818 APE9-dist-na 11.476 None None None XRAY 3.05 0.224 0.301 B 535 507 8 0 0 0 [[334, 534]] 1.0 2vwb Methanocaldococcus jannaschii OTHER_BUD32_METJA TP53RK 8.5e-45 159.9 6 218 213 466 467 468 470 472 360 384 388 448 450 449 451 483 489 484 483 482 481 480 479 478 414 Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein
OTHER STT7 C1EBN1_MICCC 4IX5A C1EBN1 151 489 489.0 ANP:60603 none Inactive None 999.0 999.0 None -120.9, 168.56 71.67, 80.19 -91.21, 21.79 297.99, 161.42 -64.36, -22.18 none-na none 999.0 Saltbr-na 999.0 HRD-na-- -71.12, -47.17 73.28, 1.59 na-in-none SNCain in-none ActLoopNT-in 2.913 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.178 0.201 A 350 339 0 0 0 0 [[62, 488]] 1.0 4ix5 Micromonas commoda OTHER_STT7_MICCC CMGC 1.3e-08 61.8 104 156 81 337 338 339 341 343 0 0 0 315 317 316 318 0 0 0 0 0 0 0 0 0 0 Protein kinase domain-containing protein
OTHER STT7 C1EBN1_MICCC 4IX5B C1EBN1 151 489 489.0 ANP:60602 none Inactive None 999.0 999.0 None -122.9, 169.14 69.98, 79.33 -89.65, 21.35 295.31, 157.7 -65.22, -20.9 none-na none 999.0 Saltbr-na 999.0 HRD-na-- -70.35, -44.14 70.61, 3.11 na-in-none SNCain in-none ActLoopNT-in 2.941 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.178 0.201 B 350 339 0 0 0 0 [[62, 488]] 1.0 4ix5 Micromonas commoda OTHER_STT7_MICCC CMGC 1.3e-08 61.8 104 156 81 337 338 339 341 343 0 0 0 315 317 316 318 0 0 0 0 0 0 0 0 0 0 Protein kinase domain-containing protein
AGC PRKACA KAPCA_MOUSE 6MM6C P05132 19 351 351.0 ANP:60402 ATPlike Inactive DFGin 6.78 16.082 ABAminus -110.74, -8.1 -141.78, 125.75 -126.67, 17.79 291.81, 81.75 -52.6, -43.19 out-out out 10.403 Saltbr-out 4.491 HRD-in -64.73, -48.52 44.91, 28.18 out-in-out SNCoio in-out ActLoopNT-in 2.877 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -155.16, 154.51 APE9-dihe-na 131.73, -155.42 APE8-dihe-in -119.09, 141.73 APE8-rot-out 198.33 APE67-dihe-in -57.79, -26.12 -45.84, -50.95 APE12-dist-in 8.53 APE11-dist-in 11.815 APE10-dist-in 6.306 APE9-dist-in 4.503 None TPO198,SEP339 TPO198,SEP339 XRAY 2.39 0.225 0.261 C 339 322 0 0 0 0 [[44, 298]] 1.0 6mm6 Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 6MM6E P05132 19 351 351.0 ANP:60401 ATPlike Inactive DFGin 6.732 15.965 ABAminus -112.26, -9.59 -137.74, 126.1 -127.73, 18.87 290.52, 82.39 -53.04, -44.19 out-out out 10.271 Saltbr-out 5.278 HRD-in -66.74, -47.88 44.41, 27.02 out-in-out SNCoio in-out ActLoopNT-in 2.873 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -157.27, 155.34 APE9-dihe-na 128.78, -154.8 APE8-dihe-in -120.26, 141.99 APE8-rot-out 197.33 APE67-dihe-in -57.79, -26.44 -45.46, -51.33 APE12-dist-in 8.478 APE11-dist-in 11.851 APE10-dist-in 6.331 APE9-dist-in 4.423 None TPO198,SEP339 TPO198,SEP339 XRAY 2.39 0.225 0.261 E 339 320 0 0 0 0 [[44, 298]] 1.0 6mm6 Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 6MM7A P05132 17 351 351.0 ANP:60406 ATPlike Inactive DFGin 6.716 15.428 ABAminus -112.23, -9.6 -137.01, 123.03 -130.15, 19.3 297.15, 81.39 -54.86, -42.58 out-out out 10.282 Saltbr-out 4.623 HRD-in -76.47, -53.66 52.13, 28.38 out-in-out SNCoio in-out ActLoopNT-in 2.863 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -163.99, 161.65 APE9-dihe-na 126.52, -159.69 APE8-dihe-in -119.22, 141.71 APE8-rot-out 195.45 APE67-dihe-in -67.85, -20.3 -44.24, -48.26 APE12-dist-in 8.204 APE11-dist-in 11.125 APE10-dist-in 5.738 APE9-dist-in 3.971 None TPO198,SEP339 TPO198,SEP339 XRAY 1.85 0.213 0.238 A 339 327 0 0 0 0 [[44, 298]] 1.0 6mm7 Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 6MM7D P05132 16 351 351.0 ANP:60405 ATPlike Inactive DFGin 6.652 15.458 ABAminus -113.01, -9.74 -137.13, 123.49 -128.55, 17.46 296.74, 82.18 -52.99, -42.79 out-out out 10.379 Saltbr-out 5.817 HRD-in -73.81, -53.25 53.83, 26.23 out-in-out SNCoio in-out ActLoopNT-in 2.874 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -166.02, 161.72 APE9-dihe-na 122.21, -160.7 APE8-dihe-in -119.01, 142.81 APE8-rot-out 192.42 APE67-dihe-in -67.72, -20.93 -42.31, -48.3 APE12-dist-in 8.21 APE11-dist-in 11.202 APE10-dist-in 5.786 APE9-dist-in 3.961 None TPO198,SEP339 TPO198,SEP339 XRAY 1.85 0.213 0.238 D 339 324 0 0 0 0 [[44, 298]] 1.0 6mm7 Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 6MM8C P05132 16 351 351.0 ANP:60403 ATPlike Inactive DFGin 6.613 15.2 ABAminus -113.8, -10.95 -132.36, 129.54 -134.0, 24.39 301.03, 83.83 -57.02, -38.35 out-out out 10.34 Saltbr-out 7.324 HRD-in -73.54, -53.96 54.41, 29.61 out-in-out SNCoio in-out ActLoopNT-in 2.776 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -159.79, 167.54 APE9-dihe-na 115.95, -161.99 APE8-dihe-in -118.41, 142.14 APE8-rot-out 195.18 APE67-dihe-in -66.48, -19.98 -46.61, -45.65 APE12-dist-in 8.125 APE11-dist-in 11.202 APE10-dist-in 5.834 APE9-dist-in 3.997 None TPO198,SEP339 TPO198,SEP339 XRAY 1.85 0.183 0.221 C 339 325 0 0 0 0 [[44, 298]] 1.0 6mm8 Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 8UKND P05132 16 351 351.0 ANP:60400 ATPlike Inactive DFGin 6.611 14.958 ABAminus -121.75, -47.3 -93.55, 119.31 -121.12, 22.25 288.77, 83.91 -60.17, -43.74 in-out in 9.636 Saltbr-out 4.003 HRD-in -71.48, -47.99 39.7, 38.93 out-in-in SNCoii in-in ActLoopNT-in 2.976 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.1, 161.55 APE9-dihe-na 104.53, 169.82 APE8-dihe-in -72.88, 137.25 APE8-rot-in 280.42 APE67-dihe-in -60.56, -25.71 -55.68, -37.9 APE12-dist-in 8.095 APE11-dist-in 11.236 APE10-dist-in 5.809 APE9-dist-in 4.692 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.75 0.197 0.232 D 339 323 0 0 0 0 [[44, 298]] 1.0 8ukn Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 8UKOE P05132 16 351 351.0 ANP:60403 ATPlike Inactive DFGin 6.036 14.596 ABAminus -122.57, -57.22 -79.99, 109.96 -108.47, 33.73 286.2, 84.93 -64.54, -41.62 in-in in 9.74 Saltbr-in 3.564 HRD-in -78.91, -48.33 66.16, 13.52 in-in-in SNCiii in-in ActLoopNT-in 2.868 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.15, 159.43 APE9-dihe-na 137.57, -133.12 APE8-dihe-in -144.28, 132.68 APE8-rot-in 289.09 APE67-dihe-in -62.87, -18.89 -48.53, -47.79 APE12-dist-in 8.08 APE11-dist-in 11.321 APE10-dist-in 5.83 APE9-dist-in 3.774 None TPO198,SEP339 TPO198,SEP339 XRAY 2.89 0.213 0.259 E 339 336 0 0 0 0 [[44, 298]] 1.0 8uko Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 8UKPE P05132 17 351 351.0 ANP:60402 ATPlike Inactive DFGin 6.134 14.43 ABAminus -106.11, -56.02 -81.74, 124.54 -123.06, 18.4 279.21, 82.41 -57.4, -55.55 in-out in 9.279 Saltbr-out 4.181 HRD-in -89.57, -52.98 66.95, 19.28 out-in-in SNCoii in-in ActLoopNT-in 2.953 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.29, 147.38 APE9-dihe-na 136.74, -150.06 APE8-dihe-in -126.21, 134.43 APE8-rot-in 318.02 APE67-dihe-in -77.56, -4.79 -54.58, -35.83 APE12-dist-in 7.928 APE11-dist-in 10.82 APE10-dist-in 5.185 APE9-dist-in 3.851 None SEP140,TPO198 SEP140,TPO198 XRAY 2.85 0.242 0.281 E 339 323 0 0 0 0 [[44, 298]] 1.0 8ukp Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 7E11A P05132 14 351 351.0 ANP:60401 ATPlike Active DFGin 6.205 14.451 BLAminus -127.38, -169.19 58.28, 74.22 -96.53, 30.74 276.22, 81.09 -66.46, -21.72 in-in in 9.053 Saltbr-in 2.551 HRD-in -91.79, -53.23 62.57, 24.02 in-in-in SNCiii in-in ActLoopNT-in 3.129 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.39, 155.98 APE9-dihe-na 134.96, -158.62 APE8-dihe-in -113.95, 132.34 APE8-rot-in 301.67 APE67-dihe-in -76.79, -1.28 -53.37, -39.68 APE12-dist-in 8.309 APE11-dist-in 11.135 APE10-dist-in 5.71 APE9-dist-in 3.659 None TPO198,SEP339 TPO198,SEP339 XRAY 3.43 0.262 0.317 A 338 337 0 0 0 0 [[44, 298]] 1.0 7e11 Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 6MM5E P05132 16 351 351.0 ANP:60402 ATPlike Inactive DFGin 5.96 14.351 BLAminus -116.65, 159.11 76.02, 91.05 -92.83, 26.22 286.06, 88.09 -52.81, -36.86 in-in in 8.849 Saltbr-in 2.8 HRD-in -83.15, -50.88 72.11, -0.72 in-in-out SNCiio in-out ActLoopNT-in 2.871 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -156.6, 159.33 APE9-dihe-na 129.67, -150.44 APE8-dihe-in -128.62, 141.57 APE8-rot-out 194.03 APE67-dihe-in -68.05, -20.18 -46.89, -45.89 APE12-dist-in 8.207 APE11-dist-in 11.378 APE10-dist-in 5.798 APE9-dist-in 3.776 None TPO198,SEP339 TPO198,SEP339 XRAY 1.95 0.183 0.227 E 339 336 0 0 0 0 [[44, 298]] 1.0 6mm5 Mus musculus AGC_PRKACA_MOUSE AGC 1.3e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3PVBA P05132 7 351 351.0 ANP:60400 ATPlike Active DFGin 5.261 14.107 BLAminus -138.85, 171.16 63.11, 82.89 -89.43, -59.95 273.17, 54.43 27.14, -66.26 in-in in 8.685 Saltbr-in 3.476 HRD-in -84.36, -35.8 62.24, -18.82 in-in-in SNCiii in-in ActLoopNT-in 3.217 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -177.84, 157.88 APE9-dihe-na 132.55, -154.74 APE8-dihe-in -122.19, 108.01 APE8-rot-in 318.81 APE67-dihe-in -60.75, -2.24 -13.41, -60.33 APE12-dist-in 7.733 APE11-dist-in 10.579 APE10-dist-in 5.511 APE9-dist-in 4.042 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 3.3 0.242 0.29 A 345 345 0 0 0 0 [[44, 298]] 1.0 3pvb Mus musculus AGC_PRKACA_MOUSE AGC 1.4e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 2QCSA P05132 14 351 351.0 ANP:60400 ATPlike Active DFGin 5.648 14.291 BLAminus -119.78, 176.88 65.56, 77.31 -85.05, 19.39 273.35, 51.28 -44.32, -42.51 in-in in 8.784 Saltbr-in 2.638 HRD-in -93.14, -54.78 73.52, 10.18 in-in-in SNCiii in-in ActLoopNT-in 2.735 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.52, 149.74 APE9-dihe-na 148.64, -142.53 APE8-dihe-in -132.36, 132.12 APE8-rot-in 297.18 APE67-dihe-in -64.67, -25.45 -36.74, -53.73 APE12-dist-in 8.133 APE11-dist-in 11.321 APE10-dist-in 5.851 APE9-dist-in 3.573 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.2 0.194 0.225 A 350 338 0 0 0 0 [[44, 298]] 1.0 2qcs Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3IDBA P05132 9 351 351.0 ANP:60450 ATPlike Active DFGin 5.346 14.413 BLAminus -121.17, -175.1 59.7, 79.28 -94.34, 24.01 267.69, 48.22 -48.56, -33.02 in-in in 8.845 Saltbr-in 2.694 HRD-in -80.07, -50.75 69.18, 11.1 in-in-in SNCiii in-in ActLoopNT-in 2.99 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.99, 160.5 APE9-dihe-na 138.4, -150.07 APE8-dihe-in -124.64, 132.33 APE8-rot-in 296.41 APE67-dihe-in -59.26, -21.93 -30.94, -63.4 APE12-dist-in 8.102 APE11-dist-in 11.573 APE10-dist-in 6.068 APE9-dist-in 3.445 None TPO198,SEP339 TPO198,SEP339 XRAY 1.62 0.206 0.23 A 350 343 0 0 0 0 [[44, 298]] 1.0 3idb Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3IDCA P05132 9 351 351.0 ANP:60450 ATPlike Active DFGin 5.079 14.472 BLAminus -127.31, 174.57 68.22, 96.34 -111.15, 30.11 265.57, 49.45 -62.75, -22.0 in-in in 8.642 Saltbr-in 3.031 HRD-in -69.04, -44.03 64.09, 13.38 in-in-in SNCiii in-in ActLoopNT-in 2.856 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.35, 157.69 APE9-dihe-na 142.7, -132.16 APE8-dihe-in -139.58, 115.88 APE8-rot-in 293.03 APE67-dihe-in -54.66, -5.54 -16.73, -78.3 APE12-dist-in 7.844 APE11-dist-in 11.373 APE10-dist-in 6.164 APE9-dist-in 3.675 None TPO198,SEP339 TPO198,SEP339 XRAY 2.7 0.241 0.319 A 350 343 0 0 0 0 [[44, 298]] 1.0 3idc Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DG0E P05132 11 351 351.0 ANP:60402 ATPlike Active DFGin 5.583 14.342 BLAminus -118.87, 179.66 65.44, 79.89 -93.34, 25.25 272.35, 58.42 -52.71, -36.39 in-in in 8.955 Saltbr-in 2.699 HRD-in -84.35, -52.45 74.02, 7.32 in-in-in SNCiii in-in ActLoopNT-in 2.895 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.07, 161.1 APE9-dihe-na 130.81, -146.6 APE8-dihe-in -130.07, 130.32 APE8-rot-in 303.85 APE67-dihe-in -61.09, -22.5 -44.14, -49.24 APE12-dist-in 8.008 APE11-dist-in 11.498 APE10-dist-in 5.9 APE9-dist-in 3.389 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.0 0.196 0.228 E 350 341 0 0 0 0 [[44, 298]] 1.0 4dg0 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DH7A P05132 16 351 351.0 ANP:60403 ATPlike Active DFGin 5.574 14.349 BLAminus -124.43, -175.45 59.33, 78.79 -93.54, 24.71 270.97, 54.79 -50.12, -38.03 in-in in 9.025 Saltbr-in 2.724 HRD-in -76.49, -50.79 66.5, 11.01 in-in-in SNCiii in-in ActLoopNT-in 2.961 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.18, 162.39 APE9-dihe-na 131.3, -151.54 APE8-dihe-in -126.44, 134.15 APE8-rot-in 300.19 APE67-dihe-in -56.38, -25.77 -37.48, -60.34 APE12-dist-in 8.093 APE11-dist-in 11.455 APE10-dist-in 5.87 APE9-dist-in 3.417 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.8 0.179 0.194 A 350 336 0 0 0 0 [[44, 298]] 1.0 4dh7 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DH8A P05132 16 351 351.0 ANP:60403 ATPlike Active DFGin 5.901 14.014 BLAminus -123.95, -176.77 59.01, 85.18 -98.8, 24.84 279.52, 63.26 -51.76, -30.5 in-in in 8.8 Saltbr-in 2.713 HRD-in -77.99, -56.65 70.43, 3.78 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.95, 158.57 APE9-dihe-na 135.16, -154.79 APE8-dihe-in -124.8, 132.89 APE8-rot-in 296.53 APE67-dihe-in -58.95, -25.2 -38.46, -56.52 APE12-dist-in 8.145 APE11-dist-in 11.475 APE10-dist-in 5.904 APE9-dist-in 3.511 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.3 0.155 0.188 A 350 336 0 0 0 0 [[44, 298]] 1.0 4dh8 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4HPTE P05132 15 351 351.0 ANP:60401 ATPlike Active DFGin 5.748 14.424 BLAminus -115.4, 178.03 67.73, 81.09 -92.11, 21.69 273.09, 55.37 -58.71, -29.4 in-in in 9.053 Saltbr-in 2.66 HRD-in -90.64, -54.09 71.81, 9.39 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.27, 162.98 APE9-dihe-na 129.56, -147.32 APE8-dihe-in -127.39, 129.92 APE8-rot-in 299.02 APE67-dihe-in -63.31, -27.9 -40.61, -49.36 APE12-dist-in 8.069 APE11-dist-in 11.385 APE10-dist-in 5.825 APE9-dist-in 3.573 None TPO198,SEP339 TPO198,SEP339 XRAY 2.15 0.189 0.228 E 350 337 0 0 0 0 [[44, 298]] 1.0 4hpt Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4HPUE P05132 13 351 351.0 ANP:60402 ATPlike Active DFGin 5.551 14.407 BLAminus -117.63, -178.61 63.83, 78.8 -92.22, 24.46 271.46, 55.23 -53.69, -32.94 in-in in 9.031 Saltbr-in 2.692 HRD-in -87.73, -52.35 74.85, 8.01 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.41, 162.17 APE9-dihe-na 134.1, -149.11 APE8-dihe-in -128.69, 136.04 APE8-rot-in 297.56 APE67-dihe-in -58.67, -24.48 -48.3, -49.81 APE12-dist-in 8.063 APE11-dist-in 11.507 APE10-dist-in 5.886 APE9-dist-in 3.403 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.55 0.173 0.194 E 350 339 0 0 0 0 [[44, 298]] 1.0 4hpu Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DFXE P05132 2 351 351.0 ANP:60402 ATPlike Active DFGin 5.524 14.286 BLAminus -116.71, -179.39 66.13, 78.01 -91.08, 23.34 272.63, 51.46 -56.59, -32.27 in-in in 8.873 Saltbr-in 2.729 HRD-in -88.99, -54.58 73.79, 11.03 in-in-in SNCiii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.69, 159.64 APE9-dihe-na 138.16, -148.52 APE8-dihe-in -130.4, 136.32 APE8-rot-in 296.63 APE67-dihe-in -59.91, -24.0 -47.38, -49.37 APE12-dist-in 8.046 APE11-dist-in 11.41 APE10-dist-in 5.819 APE9-dist-in 3.392 K8C SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.35 0.157 0.179 E 350 350 0 0 0 0 [[44, 298]] 1.0 4dfx Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4XW4A P05132 15 351 351.0 ANP:60403 ATPlike Active DFGin 5.673 14.562 BLAminus -117.82, -177.44 65.15, 79.34 -92.69, 26.58 269.45, 57.64 -61.99, -28.36 in-in in 8.931 Saltbr-in 2.858 HRD-in -86.05, -50.94 67.2, 15.72 in-in-in SNCiii in-in ActLoopNT-in 3.014 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.62, 159.69 APE9-dihe-na 135.12, -140.29 APE8-dihe-in -136.84, 125.12 APE8-rot-in 301.75 APE67-dihe-in -61.52, -26.6 -45.5, -44.66 APE12-dist-in 7.961 APE11-dist-in 11.419 APE10-dist-in 5.935 APE9-dist-in 3.664 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.82 0.183 0.24 A 356 337 0 0 0 0 [[44, 298]] 1.0 4xw4 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 7E0ZA P05132 14 351 351.0 ANP:60401 ATPlike Active DFGin 5.566 13.884 BLAminus -118.85, -174.47 59.93, 79.47 -94.43, 25.89 275.59, 63.85 -59.78, -31.6 in-in in 8.624 Saltbr-in 2.978 HRD-in -96.8, -56.38 78.26, 13.74 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.91, 162.74 APE9-dihe-na 131.67, -149.57 APE8-dihe-in -131.04, 130.65 APE8-rot-in 294.41 APE67-dihe-in -63.42, -12.5 -45.48, -52.1 APE12-dist-in 7.9 APE11-dist-in 11.182 APE10-dist-in 5.721 APE9-dist-in 3.4 None TPO198,SEP339 TPO198,SEP339 XRAY 2.162 0.184 0.228 A 358 337 0 0 0 0 [[44, 298]] 1.0 7e0z Mus musculus AGC_PRKACA_MOUSE AGC 1.6e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 7E12A P05132 19 351 351.0 ANP:60401 ATPlike Inactive DFGin 5.396 14.617 BLAminus -131.26, -169.7 58.92, 77.12 -93.02, 37.73 266.27, 47.03 -71.49, -23.13 in-in in 8.807 Saltbr-in 3.266 HRD-out -127.04, 103.44 -105.61, 37.91 in-in-in SNCiii in-in ActLoopNT-in 2.903 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.78, 159.74 APE9-dihe-na 134.39, -158.49 APE8-dihe-in -118.85, 128.69 APE8-rot-in 308.98 APE67-dihe-in -63.3, -26.53 -50.37, -37.69 APE12-dist-in 8.03 APE11-dist-in 11.372 APE10-dist-in 5.965 APE9-dist-in 3.422 None TPO198,SEP339 TPO198,SEP339 XRAY 2.796 0.208 0.252 A 358 333 0 0 0 0 [[44, 298]] 1.0 7e12 Mus musculus AGC_PRKACA_MOUSE AGC 1.6e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DG3E P05132 15 351 351.0 ANP:60401 ATPlike Active DFGin 5.481 14.342 BLAminus -115.99, -176.62 61.62, 77.98 -90.25, 24.84 270.29, 54.4 -55.44, -35.73 in-in in 8.842 Saltbr-in 2.695 HRD-in -87.1, -53.93 73.82, 10.76 in-in-in SNCiii in-in ActLoopNT-in 2.882 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.46, 161.61 APE9-dihe-na 135.41, -150.07 APE8-dihe-in -129.52, 135.22 APE8-rot-in 300.3 APE67-dihe-in -58.11, -23.91 -46.28, -51.67 APE12-dist-in 8.143 APE11-dist-in 11.482 APE10-dist-in 5.886 APE9-dist-in 3.405 R337A SEP140,TPO198 SEP140,TPO198 XRAY 1.8 0.185 0.217 E 371 337 0 0 0 0 [[44, 298]] 1.0 4dg3 Mus musculus AGC_PRKACA_MOUSE AGC 1.8e-94 321.8 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3O7LB P05132 18 351 351.0 ANP:60354 ATPlike Inactive DFGin 5.79 14.666 BLAminus -108.29, -170.95 57.63, 74.91 -94.92, 22.34 267.93, 64.07 -48.2, -34.6 in-in in 9.098 Saltbr-in 2.998 HRD-in -84.13, -53.04 68.25, 25.66 in-in-out SNCiio in-out ActLoopNT-in 2.95 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -140.78, 178.73 APE9-dihe-na 123.03, -156.78 APE8-dihe-in -134.79, 129.02 APE8-rot-out 131.03 APE67-dihe-in -64.87, -13.33 -37.09, -52.44 APE12-dist-in 8.115 APE11-dist-in 11.126 APE10-dist-in 5.593 APE9-dist-in 3.48 None TPO198 TPO198 XRAY 2.8 0.216 0.287 B 350 327 3 0 0 0 [[44, 298]] 1.0 3o7l Mus musculus AGC_PRKACA_MOUSE AGC 8.9e-94 319.5 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3FHIA P05132 14 351 351.0 ANP:60400 ATPlike Active DFGin 5.463 14.263 BLAminus -118.0, -179.45 64.04, 75.7 -86.07, 24.14 267.17, 53.33 -59.82, -32.06 in-in in 8.887 Saltbr-in 2.79 HRD-in -94.84, -53.37 68.02, 7.49 in-in-in SNCiii in-in ActLoopNT-in 2.865 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.67, 136.88 APE9-dihe-na 156.84, -158.52 APE8-dihe-in -126.08, 132.83 APE8-rot-in 296.09 APE67-dihe-in -67.08, -19.88 -42.62, -50.01 APE12-dist-in 8.233 APE11-dist-in 11.12 APE10-dist-in 5.402 APE9-dist-in 3.564 C200A TPO198,SEP339 TPO198,SEP339 XRAY 2.0 0.199 0.226 A 350 338 0 0 0 0 [[44, 298]] 1.0 3fhi Mus musculus AGC_PRKACA_MOUSE AGC 1e-93 319.3 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC RPS6KA3-1 KS6A3_MOUSE 3G51A P18654 47 346 740.0 ANP:480 ATPlike Inactive DFGin 5.92 11.041 None -85.91, -4.29 -148.29, 179.42 -140.68, 33.76 40.5, 80.74 98.88, 16.23 none-none none 999.0 Saltbr-none 999.0 HRD-in -65.38, -43.56 85.71, -58.97 none-out-none SNCnon out-none ActLoopNT-out 10.075 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 76.27 APE8-rot-in 334.43 APE67-dihe-in -57.95, -24.46 -80.48, -16.88 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.8 0.216 0.248 A 325 280 20 0 0 11 [[68, 327], [422, 679]] 2.0 3g51 Mus musculus AGC_RPS6KA3-1_MOUSE AGC 2.6e-97 330.9 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
CAMK CAMK2A KCC2A_MOUSE 7B56B P11798 5 307 478.0 ANP:60401 ATPlike Active DFGin 6.729 14.232 BLAminus -127.69, 175.68 61.5, 79.97 -89.44, 23.96 289.95, 77.46 -66.33, -24.14 in-in in 8.963 Saltbr-in 2.797 HRD-in -75.83, -42.64 71.61, -6.11 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.35, 145.48 APE9-dihe-na 136.45, -166.63 APE8-dihe-in -115.36, 130.21 APE8-rot-in 297.52 APE67-dihe-in -66.37, -13.84 -48.36, -50.63 APE12-dist-in 10.406 APE11-dist-in 11.67 APE10-dist-in 5.883 APE9-dist-in 3.799 T305A,T306A None None XRAY 1.45 0.191 0.215 B 317 303 0 0 0 0 [[13, 271]] 1.0 7b56 Mus musculus CAMK_CAMK2A_MOUSE CAMK 1.7e-96 328.6 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK MELK MELK_MOUSE 4BFMA Q61846 2 326 643.0 ANP:61000 ATPlike None DFGin 6.712 14.57 BLAminus -130.6, -176.06 61.21, 74.64 -103.71, 23.71 285.06, 77.6 -76.76, -13.34 in-in in 8.847 Saltbr-in 2.958 HRD-in -75.69, -53.65 79.25, -5.08 in-in-none SNCiin in-none ActLoopNT-in 2.981 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnii APE10-dihe-na 999.0, 98.82 APE9-dihe-na 96.69, 172.23 APE8-dihe-in -57.02, 129.84 APE8-rot-in 295.1 APE67-dihe-in -57.11, -19.89 -56.29, -48.9 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.443 APE9-dist-in 3.747 T167E None None XRAY 2.35 0.177 0.208 A 334 308 17 0 0 12 [[11, 263]] 1.0 4bfm Mus musculus CAMK_MELK_MOUSE CAMK 3.3e-88 301.6 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
OTHER POMK SG196_MOUSE 5GZ9A Q3TUA9 54 337 349.0 ANP:1001,MAN:1004 ATPlike,Allosteric Pseudo DFGin 5.293 13.023 ABAminus -119.99, -54.35 -93.01, 108.48 -116.58, 23.4 308.09, 4.31 -55.72, -49.95 none-na none 999.0 Saltbr-na 999.0 HRD-out -81.79, 73.24 -60.09, -38.65 na-in-out SNCaio in-out ActLoopNT-in 3.248 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_iioo APE10-dihe-na -60.33, 128.48 APE9-dihe-na -97.57, 144.89 APE8-dihe-in -131.17, 161.49 APE8-rot-na 301.17 APE67-dihe-out -101.62, -18.24 97.94, -172.65 APE12-dist-in 12.549 APE11-dist-in 13.729 APE10-dist-out 17.531 APE9-dist-out 9.743 N66Q,N164Q None None XRAY 2.4 0.234 0.268 A 305 280 4 0 0 2 [[73, 337]] 1.0 5gz9 Mus musculus OTHER_POMK_MOUSE POMK 1.2e-147 496.2 1 265 265 225 226 227 229 231 107 121 125 200 202 201 203 280 256 251 250 249 248 247 246 245 149 Protein O-mannose kinase
STE STK39 STK39_MOUSE 5DBXA Q9Z1W9 65 365 556.0 ANP:401 ATPlike Inactive DFGin 6.871 15.587 None -61.74, 151.25 -53.68, 129.38 -99.47, -2.77 72.69, 109.41 -58.5, -56.73 out-out out 16.025 Saltbr-out 17.435 HRD-in -69.21, -49.56 75.54, -19.7 out-out-out SNCooo out-out ActLoopNT-out 5.674 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -90.7, -9.1 APE9-dihe-na -96.35, 164.45 APE8-dihe-in -91.01, 125.18 APE8-rot-in 324.0 APE67-dihe-in -65.76, -19.67 -49.27, -43.15 APE12-dist-none 999.0 APE11-dist-out 25.041 APE10-dist-out 28.217 APE9-dist-out 27.348 T243D None CAS71,CAS128,CAS249,CAS346 XRAY 2.5 0.208 0.246 A 328 288 13 0 0 13 [[75, 349]] 1.0 5dbx Mus musculus STE_STK39_MOUSE STE 2.3e-90 308.4 1 257 257 221 222 223 225 227 104 121 125 201 203 202 204 267 254 249 248 247 246 245 244 243 151 STE20/SPS1-related proline-alanine-rich protein kinase
STE STK39 STK39_MOUSE 5DBXB Q9Z1W9 65 364 556.0 ANP:401 ATPlike Inactive DFGin 6.331 15.068 None -67.52, 160.16 -60.64, 125.44 -102.44, -1.98 62.33, 96.08 -52.97, -52.55 out-out out 14.036 Saltbr-out 13.266 HRD-in -73.49, -48.67 74.98, -19.73 out-out-out SNCooo out-out ActLoopNT-out 5.675 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooo APE10-dihe-na -104.19, 109.41 APE9-dihe-na 87.86, -153.92 APE8-dihe-in -128.52, 139.93 APE8-rot-in 317.58 APE67-dihe-in -74.81, -17.12 -52.01, -48.65 APE12-dist-none 999.0 APE11-dist-out 25.567 APE10-dist-out 25.16 APE9-dist-out 27.74 T243D None CAS71,CAS128,CAS249,CAS346 XRAY 2.5 0.208 0.246 B 328 286 14 0 0 10 [[75, 349]] 1.0 5dbx Mus musculus STE_STK39_MOUSE STE 2.3e-90 308.4 1 257 257 221 222 223 225 227 104 121 125 201 203 202 204 267 254 249 248 247 246 245 244 243 151 STE20/SPS1-related proline-alanine-rich protein kinase
TKL RIPK3 RIPK3_MOUSE 4M69A Q9QZL0 12 312 486.0 ANP:60401 ATPlike Inactive DFGin 6.32 13.402 BLBplus -137.99, 167.73 62.19, 26.69 -80.85, 141.15 41.42, 94.11 79.17, -4.63 out-out out 16.188 Saltbr-out 16.694 HRD-in -64.86, -72.1 85.35, 0.02 out-out-out SNCooo out-out ActLoopNT-out 6.434 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -38.44, -35.37 APE9-dihe-na -67.82, -39.64 APE8-dihe-out -81.63, -25.9 APE8-rot-out 193.07 APE67-dihe-in -56.22, -29.66 -74.57, -26.5 APE12-dist-out 15.23 APE11-dist-out 16.641 APE10-dist-out 19.236 APE9-dist-out 12.364 None SEP184,TPO231,SEP232 SEP184,TPO231,SEP232 XRAY 2.497 0.222 0.246 A 313 287 14 0 0 14 [[20, 290]] 1.0 4m69 Mus musculus TKL_RIPK3_MOUSE TKL 7.1e-60 208.7 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TYR EPHB2 EPHB2_MOUSE 1JPAA P54763 594 892 986.0 ANP:60400 ATPlike Inactive DFGin 5.709 15.489 None -134.81, -163.21 68.34, 57.99 -95.68, 999.0 294.45, 106.32 999.0, 999.0 in-in in 7.779 Saltbr-in 3.019 HRD-in -67.2, -47.6 76.65, -18.41 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -14.15 APE8-rot-na 35.93 APE67-dihe-in -72.25, 3.83 -49.21, -49.54 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y596F,Y602F None None XRAY 1.91 0.231 0.27 A 312 273 26 0 0 23 [[621, 882]] 1.0 1jpa Mus musculus TYR_EPHB2_MOUSE TYR 5.1e-109 369.5 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR EPHB2 EPHB2_MOUSE 1JPAB P54763 594 891 986.0 ANP:60401 ATPlike Inactive DFGin 5.732 15.627 None -133.42, -158.93 64.89, 61.18 -100.9, 999.0 292.25, 96.96 999.0, 999.0 in-in in 7.815 Saltbr-in 2.686 HRD-in -67.92, -50.57 78.02, -16.62 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -24.77 APE8-rot-na 326.13 APE67-dihe-in -71.91, 4.89 -51.95, -48.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 Y596F,Y602F None None XRAY 1.91 0.231 0.27 B 312 269 29 0 0 23 [[621, 882]] 1.0 1jpa Mus musculus TYR_EPHB2_MOUSE TYR 5.1e-109 369.5 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR LYN LYN_MOUSE 2ZV8A P25911 239 501 512.0 ANP:60001 ATPlike Active DFGin 6.207 14.166 BLAminus -127.46, 176.54 66.14, 76.26 -98.89, 34.27 306.37, 82.39 -66.23, -26.52 in-in in 8.182 Saltbr-in 2.888 HRD-na-N -93.92, -49.32 76.02, -10.27 in-in-in SNCiii in-in ActLoopNT-in 2.954 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -123.91, 116.52 APE9-dihe-in -60.43, 148.58 APE8-dihe-in -80.52, 92.26 APE8-rot-na 28.17 APE67-dihe-in -68.44, -3.54 -43.41, -52.9 APE12-dist-na 9.634 APE11-dist-na 5.923 APE10-dist-na 9.729 APE9-dist-in 5.004 None None None XRAY 2.7 0.201 0.245 A 279 256 7 0 0 7 [[247, 499]] 1.0 2zv8 Mus musculus TYR_LYN_MOUSE TYR 4.1e-95 323.9 1 260 260 384 385 386 388 390 275 290 294 364 366 365 367 425 413 408 407 406 405 404 403 402 320 Tyrosine-protein kinase Lyn
OTHER PAN3 PAN3_NEUCR 4CZYB Q7SDP4 234 645 656.0 ANP:61650 ATPlike Pseudo DFGin 8.636 12.999 None -108.01, 7.82 -124.9, 18.28 -71.16, 143.54 291.41, 999.0 81.95, -4.35 out-na out 13.97 Saltbr-na 999.0 HRD-in -64.78, -43.28 69.3, -58.59 na-out-na SNCaoa out-na ActLoopNT-out 7.042 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -68.73, -37.24 APE9-dihe-na -75.95, -42.57 APE8-dihe-na -71.33, -35.43 APE8-rot-na 302.88 APE67-dihe-na -61.0, -48.02 -101.37, 21.03 APE12-dist-na 1.544 APE11-dist-na 4.84 APE10-dist-na 5.824 APE9-dist-na 11.769 None None None XRAY 3.4 0.223 0.263 B 429 403 6 0 0 0 [[258, 516]] 1.0 4czy Neurospora crassa OTHER_PAN3_NEUCR PAN3 3.4e-53 189.3 4 264 261 424 425 426 428 430 302 318 322 405 407 406 408 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
OTHER PAN3 PAN3_NEUCR 4CZYD Q7SDP4 234 645 656.0 ANP:61650 ATPlike Pseudo DFGin 8.389 12.627 None -108.63, 8.9 -122.37, 20.29 -71.82, 141.42 292.67, 999.0 81.18, -5.38 out-na out 13.908 Saltbr-na 999.0 HRD-in -65.6, -43.11 68.0, -59.39 na-out-na SNCaoa out-na ActLoopNT-out 6.96 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -69.97, -39.27 APE9-dihe-na -74.97, -41.75 APE8-dihe-na -69.88, -35.71 APE8-rot-na 304.18 APE67-dihe-na -59.83, -48.03 -102.6, 21.19 APE12-dist-na 1.535 APE11-dist-na 4.833 APE10-dist-na 5.688 APE9-dist-na 12.012 None None None XRAY 3.4 0.223 0.263 D 429 403 6 0 0 0 [[258, 516]] 1.0 4czy Neurospora crassa OTHER_PAN3_NEUCR PAN3 3.4e-53 189.3 4 264 261 424 425 426 428 430 302 318 322 405 407 406 408 449 439 434 433 432 431 430 429 428 352 PAN2-PAN3 deadenylation complex subunit pan3
STE MAP2K1 MP2K1_RABIT 7JUWC P29678 40 382 393.0 ANP:401 ATPlike Inactive DFGin 5.476 13.481 BLBplus -119.08, 163.59 62.65, 35.07 -73.68, 154.5 52.17, 104.28 -73.77, 81.69 out-out out 15.47 Saltbr-out 15.978 HRD-in -78.46, -50.39 75.67, -1.62 out-out-out SNCooo out-out ActLoopNT-out 9.094 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -134.09, 125.81 APE9-dihe-na -89.61, -160.68 APE8-dihe-out -92.22, -18.15 APE8-rot-out 194.93 APE67-dihe-out -134.04, 131.23 -117.23, 164.93 APE12-dist-out 17.348 APE11-dist-out 16.614 APE10-dist-out 20.582 APE9-dist-out 12.609 None None None XRAY 2.88 0.245 0.286 C 384 311 32 0 0 0 [[68, 361]] 1.0 7juw Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JURC P29678 41 381 393.0 ANP:401,QOM:402 ATPlike,Type1 Inactive DFGin 6.613 14.002 BLBplus -156.22, 177.66 63.23, 45.15 -109.91, 167.01 49.79, 96.28 -84.59, 94.82 out-out out 15.273 Saltbr-out 15.878 HRD-in -66.44, -49.39 76.73, -8.84 out-out-out SNCooo out-out ActLoopNT-out 9.509 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -118.97, 111.39 APE9-dihe-na -105.66, -145.56 APE8-dihe-out -103.38, -4.62 APE8-rot-out 47.7 APE67-dihe-out -108.36, 139.88 -114.51, 107.19 APE12-dist-out 17.048 APE11-dist-out 19.986 APE10-dist-out 22.012 APE9-dist-out 15.145 None None None XRAY 2.82 0.237 0.277 C 384 304 37 0 0 0 [[68, 361]] 1.0 7jur Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JUTC P29678 41 380 393.0 ANP:401,3EW:402 ATPlike,Type3 Inactive DFGin 6.067 13.94 BLBplus -133.84, -178.36 52.69, 31.27 -86.2, 157.2 55.82, 93.16 -83.8, 97.49 out-out out 15.809 Saltbr-out 15.075 HRD-in -69.63, -49.75 78.05, -10.01 out-out-out SNCooo out-out ActLoopNT-out 9.552 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -106.95, 117.74 APE9-dihe-na -110.82, -149.07 APE8-dihe-out -94.42, -11.28 APE8-rot-out 36.3 APE67-dihe-out -120.05, 132.49 -111.03, 116.45 APE12-dist-out 17.24 APE11-dist-out 19.824 APE10-dist-out 21.751 APE9-dist-out 14.824 None None None XRAY 3.09 0.259 0.3 C 384 303 37 0 0 0 [[68, 361]] 1.0 7jut Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JUUC P29678 43 381 393.0 ANP:401,4BM:402 ATPlike,Type3 Inactive DFGin 6.574 14.008 BLBplus -143.65, 177.32 57.69, 37.46 -92.33, 152.26 41.94, 94.89 -75.77, 92.54 out-out out 15.833 Saltbr-out 14.739 HRD-in -70.37, -49.34 74.88, -6.99 out-out-out SNCooo out-out ActLoopNT-out 9.336 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -102.48, 121.01 APE9-dihe-na -118.18, -151.72 APE8-dihe-out -92.91, -15.39 APE8-rot-out 41.03 APE67-dihe-out -126.24, 128.64 -103.62, 122.66 APE12-dist-out 16.812 APE11-dist-out 19.575 APE10-dist-out 21.5 APE9-dist-out 14.815 None None None XRAY 3.19 0.242 0.258 C 384 302 37 0 0 0 [[68, 361]] 1.0 7juu Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JUVC P29678 41 381 393.0 ANP:401,VKG:402 ATPlike,Type3 Inactive DFGin 6.242 14.018 BLBplus -157.56, 157.79 64.55, 38.6 -93.84, 164.37 42.83, 100.3 -83.58, 81.75 out-out out 16.031 Saltbr-out 15.41 HRD-in -64.23, -51.09 77.84, -3.99 out-out-out SNCooo out-out ActLoopNT-out 9.291 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -121.06, 123.07 APE9-dihe-na -111.51, -147.21 APE8-dihe-out -99.25, -5.79 APE8-rot-out 47.73 APE67-dihe-out -106.23, 137.61 -113.69, 113.69 APE12-dist-out 16.969 APE11-dist-out 20.03 APE10-dist-out 21.614 APE9-dist-out 15.13 None None None XRAY 3.36 0.242 0.255 C 384 304 37 0 0 0 [[68, 361]] 1.0 7juv Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JUXC P29678 40 381 393.0 ANP:401,QOM:402 ATPlike,Type3 Inactive DFGin 6.428 14.356 BLBplus -129.48, -171.66 44.07, 32.82 -84.98, 164.12 41.6, 98.75 -82.14, 71.95 out-out out 17.586 Saltbr-out 20.192 HRD-in -72.38, -56.06 82.77, -10.45 out-out-out SNCooo out-out ActLoopNT-out 9.197 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -105.79, 149.07 APE9-dihe-na -128.12, -140.49 APE8-dihe-out -102.97, -28.75 APE8-rot-out 180.26 APE67-dihe-out -123.35, 132.01 -101.05, 135.7 APE12-dist-out 15.961 APE11-dist-out 18.645 APE10-dist-out 21.127 APE9-dist-out 13.976 None None None XRAY 3.34 0.265 0.283 C 384 308 34 0 0 0 [[68, 361]] 1.0 7jux Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JUYC P29678 40 382 393.0 ANP:401,EUI:402 ATPlike,Type3 Inactive DFGin 5.802 13.945 BLBplus -119.74, 162.94 62.38, 34.15 -75.02, 153.8 53.17, 104.23 -74.72, 81.57 out-out out 15.69 Saltbr-out 15.776 HRD-in -78.99, -50.85 75.95, -2.2 out-out-out SNCooo out-out ActLoopNT-out 8.64 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -134.38, 125.81 APE9-dihe-na -89.68, -160.4 APE8-dihe-out -91.9, -17.82 APE8-rot-out 194.83 APE67-dihe-out -134.16, 130.72 -117.22, 165.02 APE12-dist-out 17.527 APE11-dist-out 16.829 APE10-dist-out 20.535 APE9-dist-out 12.572 None None None XRAY 3.096 0.248 0.257 C 384 311 32 0 0 0 [[68, 361]] 1.0 7juy Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JUZC P29678 40 382 393.0 ANP:401,3EW:402 ATPlike,Type3 Inactive DFGin 5.941 14.245 BLBplus -127.35, 173.99 64.59, 36.11 -89.55, 153.11 55.39, 95.23 -79.11, 95.72 out-out out 16.897 Saltbr-out 15.39 HRD-in -78.66, -56.19 75.89, -1.31 out-out-out SNCooo out-out ActLoopNT-out 8.829 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -140.68, 119.69 APE9-dihe-na -83.26, -173.5 APE8-dihe-out -76.47, -20.99 APE8-rot-out 195.18 APE67-dihe-out -133.01, 129.38 -114.64, 162.26 APE12-dist-out 17.257 APE11-dist-out 16.605 APE10-dist-out 20.455 APE9-dist-out 12.423 None None None XRAY 3.21 0.255 0.272 C 384 308 35 0 0 0 [[68, 361]] 1.0 7juz Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JV0C P29678 40 382 393.0 ANP:401,4BM:402 ATPlike,Type3 Inactive DFGin 5.873 14.27 BLBplus -118.46, 167.04 65.91, 31.94 -77.55, 158.19 54.28, 101.68 -82.73, 82.06 out-out out 16.445 Saltbr-out 16.87 HRD-in -78.95, -48.37 72.45, 0.0 out-out-out SNCooo out-out ActLoopNT-out 8.977 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -134.69, 127.82 APE9-dihe-na -92.23, -161.01 APE8-dihe-out -91.79, -17.2 APE8-rot-out 194.87 APE67-dihe-out -131.33, 129.9 -118.91, 161.4 APE12-dist-out 17.567 APE11-dist-out 16.919 APE10-dist-out 20.798 APE9-dist-out 12.679 None None None XRAY 3.63 0.247 0.26 C 384 308 35 0 0 0 [[68, 361]] 1.0 7jv0 Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JV1C P29678 40 381 393.0 ANP:401,VKG:402 ATPlike,Type3 Inactive DFGin 6.403 13.987 BLBplus -129.45, -171.63 44.64, 33.58 -84.88, 163.88 41.4, 98.6 -82.69, 72.31 out-out out 17.783 Saltbr-out 17.887 HRD-in -72.64, -55.74 83.07, -10.49 out-out-out SNCooo out-out ActLoopNT-out 9.519 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -106.03, 153.74 APE9-dihe-na -129.76, -140.43 APE8-dihe-out -102.55, -29.44 APE8-rot-out 180.23 APE67-dihe-out -122.99, 132.28 -101.94, 135.93 APE12-dist-out 15.759 APE11-dist-out 19.044 APE10-dist-out 21.04 APE9-dist-out 14.153 None None None XRAY 3.62 0.278 0.303 C 384 308 34 0 0 0 [[68, 361]] 1.0 7jv1 Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_RABIT 7JUSC P29678 41 381 393.0 VKD:501,ANP:502 Type3,ATPlike Inactive DFGin 6.641 14.136 BLBplus -157.57, 158.09 64.1, 38.39 -94.54, 165.57 43.42, 100.58 -82.33, 83.96 out-out out 16.443 Saltbr-out 17.065 HRD-in -64.72, -50.01 79.43, -5.86 out-out-out SNCooo out-out ActLoopNT-out 9.206 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -121.8, 123.06 APE9-dihe-na -111.39, -149.55 APE8-dihe-out -101.45, -2.19 APE8-rot-out 46.64 APE67-dihe-out -107.18, 138.05 -110.5, 111.25 APE12-dist-out 16.956 APE11-dist-out 19.741 APE10-dist-out 21.584 APE9-dist-out 15.102 None None None XRAY 2.99 0.249 0.265 C 384 304 37 0 0 0 [[68, 361]] 1.0 7jus Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
OTHER PINK1 PINK1_PEDHC 8UYHA E0W1I1 115 574 575.0 ANP:601 ATPlike Active DFGin 9.322 14.819 BLAminus -130.08, -169.42 57.7, 62.71 -86.71, 26.39 286.61, 80.23 -66.61, -35.48 in-in in 7.967 Saltbr-in 3.27 HRD-in -73.02, -43.12 61.9, 7.28 in-in-in SNCiii in-in ActLoopNT-in 2.764 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na 161.16, -131.74 APE9-dihe-na -112.83, -108.55 APE8-dihe-in -69.42, 145.98 APE8-rot-na 76.98 APE67-dihe-in -73.97, -39.08 -95.26, -9.75 APE12-dist-in 8.048 APE11-dist-in 10.262 APE10-dist-in 5.834 APE9-dist-in 3.572 None TPO305 TPO305 EM 2.84 999.0 999.0 A 463 375 49 0 0 0 [[64, 514]] 1.0 8uyh Pediculus humanus OTHER_PINK1_PEDHC PINK1 1e-86 297.1 4 367 364 356 357 358 360 362 193 214 218 331 333 332 334 408 390 385 384 383 382 381 380 379 291 Serine/threonine-protein kinase Pink1, mitochondrial
OTHER PINK1 PINK1_PEDHC 8UYHB E0W1I1 121 574 575.0 ANP:601 ATPlike Active DFGin 9.449 14.871 BLAminus -129.89, -169.12 59.53, 64.83 -87.85, 20.05 283.99, 82.98 -70.23, -23.56 in-in in 7.846 Saltbr-in 2.387 HRD-in -70.23, -41.92 63.21, 0.58 in-in-in SNCiii in-in ActLoopNT-in 2.932 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na 144.56, -157.47 APE9-dihe-na -105.64, -99.0 APE8-dihe-in -70.54, 139.11 APE8-rot-na 52.17 APE67-dihe-in -71.03, -46.42 -78.22, -15.68 APE12-dist-in 7.74 APE11-dist-in 10.385 APE10-dist-in 6.127 APE9-dist-in 3.781 None TPO305 TPO305 EM 2.84 999.0 999.0 B 463 370 50 0 0 0 [[64, 514]] 1.0 8uyh Pediculus humanus OTHER_PINK1_PEDHC PINK1 1e-86 297.1 4 367 364 356 357 358 360 362 193 214 218 331 333 332 334 408 390 385 384 383 382 381 380 379 291 Serine/threonine-protein kinase Pink1, mitochondrial
CAMK CDPK1 CDPK1_PLABA 3Q5IA A0A509AHB6 38 518 523.0 ANP:61634 ATPlike Active DFGin 6.767 14.466 BLAminus -128.23, -176.48 60.5, 79.46 -95.96, 19.56 285.65, 75.94 -57.69, -30.19 in-in in 9.237 Saltbr-in 3.124 HRD-in -79.9, -50.9 74.57, -2.92 in-in-in SNCiii in-in ActLoopNT-in 2.988 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.44, 148.94 APE9-dihe-na 143.23, -165.03 APE8-dihe-in -126.86, 133.51 APE8-rot-in 304.61 APE67-dihe-in -56.9, -32.89 -45.51, -52.84 APE12-dist-in 8.589 APE11-dist-in 11.465 APE10-dist-in 5.667 APE9-dist-in 3.634 None None None XRAY 2.1 0.197 0.25 A 504 461 18 0 0 0 [[57, 324]] 1.0 3q5i Plasmodium berghei CAMK_CDPK1_PLABA CAMK 4e-85 291.5 4 256 253 210 211 212 214 216 86 115 119 187 189 188 190 248 237 232 231 230 229 228 227 226 145 Calcium-dependent protein kinase 1
CMGC MAPK Q7KQK7_PLAF7 3NIEA Q7KQK7 95 499 508.0 ANP:60430 ATPlike Inactive DFGin 6.659 15.776 BLAminus -144.93, -172.32 65.91, 51.77 -86.61, 14.68 283.07, 77.79 -60.63, -18.53 in-in in 8.867 Saltbr-in 2.503 HRD-in -68.06, -47.27 80.58, -8.2 in-in-out SNCiio in-out ActLoopNT-in 2.856 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -70.3, 124.83 APE9-dihe-na -125.0, 112.94 APE8-dihe-in -93.96, 116.45 APE8-rot-in 298.12 APE67-dihe-in -72.32, -16.48 -104.15, 8.37 APE12-dist-out 16.933 APE11-dist-in 12.633 APE10-dist-out 15.244 APE9-dist-out 11.2 None None None XRAY 2.3 0.225 0.268 A 429 364 41 0 0 31 [[106, 446]] 1.0 3nie Plasmodium falciparum CMGC_MAPK_PLAF7 CMGC 8.1e-36 228.5 1 161 305 249 250 251 253 255 135 153 157 229 231 230 232 315 302 297 296 295 294 293 292 291 188 Mitogen-activated protein kinase
CMGC MAPK Q7KQK7_PLAF7 3NIEB Q7KQK7 95 505 508.0 ANP:60430 ATPlike Inactive DFGin 6.221 15.356 BLAminus -134.35, -174.02 73.7, 49.83 -83.77, 18.2 290.52, 87.11 -64.56, -24.17 in-in in 8.768 Saltbr-in 2.61 HRD-in -70.6, -44.59 78.38, -12.33 in-in-out SNCiio in-out ActLoopNT-in 2.654 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -62.89, 130.52 APE9-dihe-na -133.69, 126.34 APE8-dihe-in -95.72, 114.26 APE8-rot-in 300.21 APE67-dihe-in -71.21, -11.01 -104.83, 7.14 APE12-dist-out 17.19 APE11-dist-in 12.78 APE10-dist-out 15.258 APE9-dist-out 11.218 None None None XRAY 2.3 0.225 0.268 B 429 367 44 0 0 32 [[106, 446]] 1.0 3nie Plasmodium falciparum CMGC_MAPK_PLAF7 CMGC 8.1e-36 228.5 1 161 305 249 250 251 253 255 135 153 157 229 231 230 232 315 302 297 296 295 294 293 292 291 188 Mitogen-activated protein kinase
CMGC PSTK1 Q8IL19_PLAF7 3LLTA Q8IL19 535 875 881.0 ANP:877 ATPlike Active DFGin 7.143 15.216 BLAminus -123.92, -179.42 67.73, 65.46 -96.96, 21.34 280.85, 86.26 -60.95, -43.39 in-in in 9.013 Saltbr-in 2.621 HRD-in -67.76, -41.54 71.0, -10.38 in-in-in SNCiii in-in ActLoopNT-in 2.854 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.91, 173.39 APE9-dihe-na 75.57, 154.71 APE8-dihe-in -70.15, 136.15 APE8-rot-in 300.24 APE67-dihe-in -71.32, -17.13 -39.04, -49.24 APE12-dist-in 13.205 APE11-dist-in 11.39 APE10-dist-in 7.514 APE9-dist-in 2.941 None None None XRAY 2.5 0.225 0.267 A 360 341 0 0 0 0 [[552, 874]] 1.0 3llt Plasmodium falciparum CMGC_PSTK1_PLAF7 CMGC 8.3e-71 244.6 2 301 300 719 720 721 723 725 581 596 600 674 676 675 677 756 744 739 738 737 736 735 734 733 631 Protein serine/threonine kinase-1
OTHER PK7 O96214_PLAFA 2PMLX O96214 1 316 320.0 ANP:60381 ATPlike Inactive DFGin 7.27 13.666 BLAminus -145.98, -179.86 51.66, 93.56 -100.75, 34.63 303.23, 91.32 -71.84, -18.04 out-out out 10.157 Saltbr-out 3.691 HRD-in -69.85, -44.18 75.61, 1.42 out-in-in SNCoii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -171.9, 141.96 APE9-dihe-na 131.5, -150.95 APE8-dihe-in -107.69, 124.02 APE8-rot-in 304.33 APE67-dihe-in -76.82, -4.32 -47.17, -48.3 APE12-dist-in 11.287 APE11-dist-in 11.803 APE10-dist-in 6.373 APE9-dist-in 3.68 None None None XRAY 2.6 0.261 0.327 X 348 308 8 0 0 0 [[28, 319]] 1.0 2pml Plasmodium falciparum OTHER_PK7_PLAFA CAMK 9.9e-37 136.1 1 256 256 189 190 191 193 195 55 88 92 169 171 170 172 229 215 210 209 208 207 206 205 204 118 mitogen-activated protein kinase kinase
AGC PKG KGP_PLAVS 5DZCA A5K0N4 1 843 846.0 ANP:61001 ATPlike Inactive DFGin 6.296 14.695 BLAminus -123.96, 179.25 60.5, 83.72 -97.75, 30.63 287.02, 82.05 -66.77, -34.57 out-out out 10.75 Saltbr-out 4.731 HRD-in -75.23, -49.58 78.17, -9.81 out-in-in SNCoii in-in ActLoopNT-in 2.992 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.27, 147.09 APE9-dihe-na 122.94, -168.21 APE8-dihe-in -102.7, 120.96 APE8-rot-in 294.87 APE67-dihe-in -65.78, -22.03 -47.03, -45.8 APE12-dist-in 9.444 APE11-dist-in 11.26 APE10-dist-in 5.39 APE9-dist-in 3.65 None None None XRAY 2.3 0.223 0.255 A 847 815 0 0 0 0 [[534, 791]] 1.0 5dzc Plasmodium vivax AGC_PKG_PLAVS AGC 1.3e-75 260.5 3 260 258 674 675 676 678 680 563 582 586 654 656 655 657 711 699 694 693 692 691 690 689 688 612 cGMP-dependent protein kinase
AGC PRKCB KPCB_RAT 3PFQA P68403 101 668 671.0 ANP:60800 ATPlike Inactive DFGin 6.062 13.318 BLAminus -127.91, -175.53 60.89, 88.17 -109.45, 18.93 297.91, 72.76 -66.81, 8.41 in-out in 9.319 Saltbr-out 4.511 HRD-out -53.59, -66.06 65.15, 50.69 out-in-in SNCoii in-in ActLoopNT-in 3.087 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.97, -178.34 APE9-dihe-na 109.42, -153.48 APE8-dihe-in -112.52, 141.29 APE8-rot-in 328.3 APE67-dihe-in -90.42, -60.35 -50.4, -26.29 APE12-dist-in 8.892 APE11-dist-in 11.964 APE10-dist-in 6.353 APE9-dist-in 4.034 C71S,C217S,R622S TPO500,TPO642,SEP661 TPO500,TPO642,SEP661 XRAY 4.0 0.244 0.244 A 674 521 0 0 0 0 [[342, 600]] 1.0 3pfq Rattus norvegicus AGC_PRKCB_RAT AGC 1.5e-97 332.1 1 260 260 483 484 485 487 489 371 390 394 463 465 464 466 523 511 506 505 504 503 502 501 500 421 Protein kinase C beta type
CMGC MAPK1 MK01_RAT 4S33A P63086 4 355 358.0 ANP:401 ATPlike Inactive DFGin 6.743 16.086 BLAminus -130.86, 178.79 71.13, 76.62 -98.92, 24.03 286.96, 71.68 -62.72, -21.16 in-in in 9.687 Saltbr-in 2.68 HRD-in -72.9, -49.96 78.15, -0.96 in-in-out SNCiio in-out ActLoopNT-in 2.865 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -104.41, -43.84 APE9-dihe-na -64.59, 164.35 APE8-dihe-in -56.21, 123.2 APE8-rot-in 315.9 APE67-dihe-in -61.37, -21.31 -48.55, -49.93 APE12-dist-out 14.732 APE11-dist-in 11.306 APE10-dist-in 7.311 APE9-dist-in 4.483 R65S None None XRAY 1.48 0.199 0.239 A 358 347 0 0 0 0 [[23, 311]] 1.0 4s33 Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.5e-85 293.0 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 4S32A P63086 4 354 358.0 ANP:401 ATPlike Inactive DFGin 6.646 16.335 BLAminus -133.92, 176.75 65.37, 79.23 -97.7, 23.57 287.97, 74.34 -66.64, -19.31 in-out in 9.869 Saltbr-out 3.654 HRD-in -75.76, -45.6 71.68, 4.61 out-in-out SNCoio in-out ActLoopNT-in 2.828 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -98.88, -32.08 APE9-dihe-na -65.5, 159.94 APE8-dihe-in -53.88, 129.7 APE8-rot-in 310.08 APE67-dihe-in -61.98, -20.6 -58.72, -45.65 APE12-dist-out 14.546 APE11-dist-in 11.219 APE10-dist-in 7.49 APE9-dist-in 4.433 None None None XRAY 1.34 0.199 0.231 A 358 346 0 0 0 0 [[23, 311]] 1.0 4s32 Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.3e-85 293.2 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 7UGBA P63086 9 354 358.0 ANP:60401 ATPlike Inactive DFGin 6.844 15.614 BLAminus -132.85, -175.34 66.19, 68.8 -95.15, 22.62 283.13, 71.04 -65.04, -17.4 in-in in 9.298 Saltbr-in 3.095 HRD-in -74.44, -45.95 75.99, -7.39 in-in-out SNCiio in-out ActLoopNT-in 2.76 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -141.06, 152.87 APE9-dihe-na -67.4, -32.8 APE8-dihe-in -151.29, 138.48 APE8-rot-out 186.29 APE67-dihe-in -67.11, -12.06 -109.33, 7.55 APE12-dist-in 8.519 APE11-dist-in 12.19 APE10-dist-out 9.145 APE9-dist-out 11.367 None None None XRAY 1.9 0.181 0.228 A 380 333 9 0 0 9 [[23, 311]] 1.0 7ugb Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.6e-85 292.9 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 4S34A P63086 4 354 358.0 ANP:402 ATPlike Inactive DFGin 6.931 15.921 BLAminus -141.95, 172.44 70.56, 81.84 -99.71, 28.41 294.26, 76.1 -60.19, -38.53 in-out in 9.862 Saltbr-out 3.648 HRD-in -79.44, -51.86 83.9, -4.35 out-in-out SNCoio in-out ActLoopNT-in 2.881 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -91.12, -42.94 APE9-dihe-na -58.97, 168.13 APE8-dihe-in -69.02, 123.37 APE8-rot-in 313.04 APE67-dihe-in -67.86, -24.53 -49.65, -45.75 APE12-dist-out 14.843 APE11-dist-in 11.327 APE10-dist-in 7.277 APE9-dist-in 4.481 I84A None None XRAY 2.5 0.182 0.255 A 358 343 0 0 0 0 [[23, 311]] 1.0 4s34 Rattus norvegicus CMGC_MAPK1_RAT CMGC 2.9e-85 292.1 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 8RQVA P63086 4 354 358.0 ANP:501 ATPlike Inactive DFGin 6.904 16.069 BLAminus -129.6, -175.7 63.15, 70.39 -89.62, 28.98 289.85, 76.4 -67.34, -38.13 in-out in 9.711 Saltbr-out 4.275 HRD-in -67.81, -55.04 72.76, 2.89 out-in-out SNCoio in-out ActLoopNT-in 2.765 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oiii APE10-dihe-na -100.88, -30.73 APE9-dihe-na -77.54, 159.87 APE8-dihe-in -50.38, 124.93 APE8-rot-none 999.0 APE67-dihe-in -63.77, -19.96 -54.06, -49.39 APE12-dist-out 14.154 APE11-dist-in 10.753 APE10-dist-in 7.025 APE9-dist-in 4.35 T188A None None XRAY 2.19 0.22 0.268 A 365 346 0 0 0 0 [[23, 311]] 1.0 8rqv Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.1e-84 290.1 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 8RQXA P63086 4 353 358.0 ANP:501 ATPlike Inactive DFGin 6.753 15.771 BLAminus -131.54, -179.98 70.52, 77.44 -96.49, 23.47 286.75, 76.4 -63.49, -27.29 in-out in 9.283 Saltbr-out 4.03 HRD-in -71.44, -55.38 74.63, 0.71 out-in-out SNCoio in-out ActLoopNT-in 2.862 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oiii APE10-dihe-na -102.41, -41.91 APE9-dihe-na -63.48, 155.78 APE8-dihe-in -53.17, 123.33 APE8-rot-na 196.55 APE67-dihe-in -71.02, -16.45 -50.75, -40.77 APE12-dist-out 14.212 APE11-dist-in 10.768 APE10-dist-in 6.987 APE9-dist-in 4.452 R65S,T188D None None XRAY 1.7 0.199 0.231 A 365 344 0 0 0 0 [[23, 311]] 1.0 8rqx Rattus norvegicus CMGC_MAPK1_RAT CMGC 3.4e-84 288.6 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 8RQWA P63086 4 354 358.0 ANP:501 ATPlike Inactive DFGin 6.849 16.016 BLAminus -129.63, 178.83 67.86, 79.37 -97.6, 20.5 285.29, 78.65 -60.41, -30.78 in-out in 9.771 Saltbr-out 4.065 HRD-in -69.59, -52.69 70.29, 6.23 out-in-out SNCoio in-out ActLoopNT-in 2.837 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oiii APE10-dihe-na -111.03, -43.37 APE9-dihe-na -66.74, 156.04 APE8-dihe-in -59.11, 129.69 APE8-rot-na 165.64 APE67-dihe-in -63.23, -21.3 -54.35, -46.88 APE12-dist-out 14.637 APE11-dist-in 10.923 APE10-dist-in 6.912 APE9-dist-in 4.259 T188E None None XRAY 1.8 0.198 0.231 A 365 344 0 0 0 0 [[23, 311]] 1.0 8rqw Rattus norvegicus CMGC_MAPK1_RAT CMGC 3e-84 288.8 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
OTHER WNK1 WNK1_RAT 5W7TA Q9JIH7 210 482 2126.0 ANP:60501 ATPlike Inactive DFGin 6.417 15.935 BLBtrans -104.69, 171.72 66.72, 19.42 -58.26, 129.69 184.83, 52.8 82.8, 3.34 na-na na 14.539 Saltbr-na 999.0 HRD-in -71.27, -50.06 75.36, -9.98 na-out-out SNCaoo out-out ActLoopNT-out 8.584 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -87.54, -6.4 APE9-dihe-na 140.44, -174.25 APE8-dihe-in -100.52, 116.85 APE8-rot-in 301.69 APE67-dihe-in -56.05, -31.73 -45.94, -43.4 APE12-dist-out 14.878 APE11-dist-in 11.575 APE10-dist-out 12.308 APE9-dist-in 5.421 None SEP382 SEP382 XRAY 2.01 0.175 0.227 A 277 273 0 0 0 0 [[220, 479]] 1.0 5w7t Rattus norvegicus OTHER_WNK1_RAT WNK 1.7e-180 603.7 1 260 260 367 368 369 371 373 250 268 272 346 348 347 349 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
OTHER WNK1 WNK1_RAT 5W7TB Q9JIH7 210 482 2126.0 ANP:60501 ATPlike Inactive DFGin 6.386 15.245 BLBtrans -103.97, 173.91 64.08, 22.88 -61.0, 131.49 184.03, 62.56 90.07, -15.7 na-na na 14.129 Saltbr-na 999.0 HRD-in -70.75, -51.57 74.83, -5.85 na-out-out SNCaoo out-out ActLoopNT-out 7.222 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -112.88, 5.47 APE9-dihe-na -140.59, -178.52 APE8-dihe-in -108.13, 115.32 APE8-rot-in 305.01 APE67-dihe-in -55.56, -28.14 -49.44, -36.46 APE12-dist-out 14.711 APE11-dist-in 12.593 APE10-dist-in 7.81 APE9-dist-in 4.793 None SEP382 SEP382 XRAY 2.01 0.175 0.227 B 277 273 0 0 0 0 [[220, 479]] 1.0 5w7t Rattus norvegicus OTHER_WNK1_RAT WNK 1.7e-180 603.7 1 260 260 367 368 369 371 373 250 268 272 346 348 347 349 404 393 388 387 386 385 384 383 382 302 Serine/threonine-protein kinase WNK1
AGC CBK1 CBK1_YEAST 4LQSA P53894 294 749 756.0 ANP:801 ATPlike Inactive None 999.0 16.203 None 53.14, -148.73 -160.92, 157.71 -53.16, -18.83 35.56, 134.57 105.29, -25.04 none-none none 999.0 Saltbr-none 999.0 HRD-in -66.84, -59.33 53.37, 19.81 none-out-out SNCnoo out-out ActLoopNT-out 11.527 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na 51.76, -143.69 APE9-dihe-na -76.97, 123.71 APE8-dihe-in -85.35, 159.33 APE8-rot-out 194.03 APE67-dihe-out -98.15, -1.82 -67.37, 76.79 APE12-dist-out 18.628 APE11-dist-out 18.651 APE10-dist-out 15.241 APE9-dist-out 9.908 D475A None None XRAY 3.3 0.272 0.307 A 508 372 59 0 0 44 [[352, 672]] 1.0 4lqs Saccharomyces cerevisiae AGC_CBK1_YEAST AGC 8.9e-95 322.8 1 260 260 492 493 494 496 498 381 400 404 472 474 473 475 593 581 576 575 574 573 572 571 570 430 Serine/threonine-protein kinase CBK1
AGC CBK1 CBK1_YEAST 5NCLA P53894 266 756 756.0 ANP:801 ATPlike Inactive None 999.0 14.768 None -124.95, -0.24 -167.04, -169.57 -142.87, 6.12 315.3, 73.05 87.79, 14.17 none-none none 999.0 Saltbr-none 999.0 HRD-in -82.26, -37.95 50.09, 24.61 none-out-out SNCnoo out-out ActLoopNT-out 10.084 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -121.55, -26.93 APE9-dihe-na 94.26, 55.75 APE8-dihe-in -40.67, 138.08 APE8-rot-out 180.68 APE67-dihe-out -56.77, 157.77 -73.6, -6.03 APE12-dist-out 20.631 APE11-dist-out 16.502 APE10-dist-out 17.631 APE9-dist-out 9.21 D475A None None XRAY 3.15 0.237 0.298 A 508 418 51 0 0 36 [[352, 672]] 1.0 5ncl Saccharomyces cerevisiae AGC_CBK1_YEAST AGC 8.9e-95 322.8 1 260 260 492 493 494 496 498 381 400 404 472 474 473 475 593 581 576 575 574 573 572 571 570 430 Serine/threonine-protein kinase CBK1
AGC CBK1 CBK1_YEAST 4LQPA P53894 282 749 756.0 ANP:801 ATPlike Inactive None 11.349 17.142 None 51.11, -136.69 -160.15, 166.75 -53.4, -31.02 62.24, 131.47 101.1, -24.98 none-none none 999.0 Saltbr-none 999.0 HRD-in -48.74, -51.29 56.68, 17.66 none-out-out SNCnoo out-out ActLoopNT-out 12.107 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na 57.38, -156.31 APE9-dihe-na -77.68, 150.18 APE8-dihe-in -91.6, 155.34 APE8-rot-out 192.52 APE67-dihe-out -54.18, -52.1 -73.01, 58.69 APE12-dist-out 19.628 APE11-dist-out 18.081 APE10-dist-out 14.887 APE9-dist-out 10.605 D475A,T743E None None XRAY 4.5 0.289 0.31 A 508 383 61 0 0 49 [[352, 672]] 1.0 4lqp Saccharomyces cerevisiae AGC_CBK1_YEAST AGC 8.9e-95 322.8 1 260 260 492 493 494 496 498 381 400 404 472 474 473 475 593 581 576 575 574 573 572 571 570 430 Serine/threonine-protein kinase CBK1
AGC CBK1 CBK1_YEAST 4LQQA P53894 282 749 756.0 ANP:801 ATPlike Inactive None 999.0 15.547 None 58.85, -148.63 -164.28, 166.54 -77.58, -28.26 39.76, 84.0 103.41, -23.9 none-none none 999.0 Saltbr-none 999.0 HRD-in -81.04, -47.82 56.38, 16.19 none-out-out SNCnoo out-out ActLoopNT-out 12.343 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na 56.18, -157.99 APE9-dihe-na -70.4, 122.44 APE8-dihe-in -57.31, 154.98 APE8-rot-out 175.08 APE67-dihe-out -48.49, -76.95 -95.03, 72.04 APE12-dist-out 20.096 APE11-dist-out 18.567 APE10-dist-out 14.888 APE9-dist-out 10.347 D475A,T743E None None XRAY 3.6 0.262 0.319 A 508 388 55 0 0 40 [[352, 672]] 1.0 4lqq Saccharomyces cerevisiae AGC_CBK1_YEAST AGC 8.9e-95 322.8 1 260 260 492 493 494 496 498 381 400 404 472 474 473 475 593 581 576 575 574 573 572 571 570 430 Serine/threonine-protein kinase CBK1
CAMK RAD53 RAD53_YEAST 4PDSA P22216 191 490 821.0 ANP:601 ATPlike None DFGin 6.827 15.321 BLAminus -118.08, -171.61 59.64, 71.79 -99.48, 20.29 283.31, 64.09 -58.2, -44.36 in-none in 9.066 Saltbr-none 999.0 HRD-in -71.09, -47.1 62.14, 17.47 none-in-none SNCnin in-none ActLoopNT-in 3.117 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -34.5 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 A225S,D339A None None XRAY 2.9 0.229 0.263 A 347 249 48 0 0 14 [[198, 466]] 1.0 4pds Saccharomyces cerevisiae CAMK_RAD53_YEAST CAMK 1e-76 264.0 3 256 254 338 339 340 342 344 227 244 248 316 318 317 319 390 365 360 359 358 357 356 355 354 274 Serine/threonine-protein kinase RAD53
CAMK RAD53 RAD53_YEAST 4PDSB P22216 191 494 821.0 ANP:601 ATPlike Inactive DFGin 6.718 15.148 BLAminus -117.97, -170.55 58.98, 70.83 -99.5, 20.74 286.63, 66.01 -58.38, -47.1 in-none in 9.184 Saltbr-none 999.0 HRD-in -70.11, -46.34 63.04, 16.89 none-in-out SNCnio in-out ActLoopNT-in 2.981 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 171.9 APE8-rot-out 171.12 APE67-dihe-in -69.32, -29.11 -73.88, 11.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 A225S,D339A None None XRAY 2.9 0.229 0.263 B 347 248 52 0 0 12 [[198, 466]] 1.0 4pds Saccharomyces cerevisiae CAMK_RAD53_YEAST CAMK 1e-76 264.0 3 256 254 338 339 340 342 344 227 244 248 316 318 317 319 390 365 360 359 358 357 356 355 354 274 Serine/threonine-protein kinase RAD53
CAMK RAD53 RAD53_YEAST 5XZVB P22216 32 466 821.0 ANP:60501 ATPlike Inactive DFGin 7.592 14.017 BLBminus -134.96, 173.3 66.26, 62.64 -75.82, 145.77 303.09, 74.83 -59.73, 168.49 out-out out 13.662 Saltbr-out 10.474 HRD-in -60.41, -45.87 73.76, -6.4 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -100.72, 24.79 APE9-dihe-na -115.73, -142.38 APE8-dihe-in -94.48, 113.04 APE8-rot-in 308.94 APE67-dihe-in -48.8, -28.87 -80.72, -18.69 APE12-dist-in 12.623 APE11-dist-out 16.632 APE10-dist-out 16.163 APE9-dist-out 10.329 None None None XRAY 3.1 0.273 0.289 B 471 370 29 0 0 11 [[198, 466]] 1.0 5xzv Saccharomyces cerevisiae CAMK_RAD53_YEAST CAMK 1.6e-78 269.9 3 256 254 338 339 340 342 344 227 244 248 316 318 317 319 390 365 360 359 358 357 356 355 354 274 Serine/threonine-protein kinase RAD53
CAMK RAD53 RAD53_YEAST 5XZVA P22216 16 465 821.0 ANP:60501 ATPlike Inactive DFGin 7.064 15.261 None -121.2, -53.4 -91.08, 125.25 -116.1, 93.37 279.98, 81.22 -112.86, 58.45 in-out in 9.883 Saltbr-out 4.182 HRD-out -106.71, 124.14 -85.03, 170.27 out-out-none SNCoon out-none ActLoopNT-out 5.501 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -63.22, -40.45 999.0, 55.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.1 0.273 0.289 A 471 375 42 0 0 14 [[198, 466]] 1.0 5xzv Saccharomyces cerevisiae CAMK_RAD53_YEAST CAMK 1.6e-78 269.9 3 256 254 338 339 340 342 344 227 244 248 316 318 317 319 390 365 360 359 358 357 356 355 354 274 Serine/threonine-protein kinase RAD53
CMGC CKA1 CSK21_YEAST 4JQEA P15790 3 371 372.0 ANP:401 ATPlike Inactive None 24.244 16.419 None -115.27, -174.34 56.63, 76.24 -90.39, 14.09 294.74, 85.98 -69.15, -20.82 out-na out 38.371 Saltbr-na 999.0 HRD-in -70.11, -50.73 74.01, 10.07 na-in-in SNCaii in-in ActLoopNT-in 2.873 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.74, -177.14 APE9-dihe-na 56.62, -167.2 APE8-dihe-in -120.8, 142.4 APE8-rot-in 319.02 APE67-dihe-in -66.52, -14.17 -32.33, -59.31 APE12-dist-in 12.384 APE11-dist-in 10.377 APE10-dist-in 6.015 APE9-dist-in 3.033 None None None XRAY 1.77 0.206 0.246 A 374 369 0 0 0 0 [[100, 363]] 1.0 4jqe Saccharomyces cerevisiae CMGC_CKA1_YEAST CMGC 0.0001 199.7 1 55 321 213 214 215 217 219 69 114 118 192 194 193 195 253 240 235 234 233 232 231 230 229 153 Casein kinase II subunit alpha
CMGC SKY1 SKY1_YEAST 1Q99A Q03656 143 737 742.0 ANP:60901 ATPlike Active DFGin 5.863 12.817 BLAminus -114.29, -177.44 55.8, 69.3 -86.87, 21.69 289.5, 16.74 -63.01, -13.14 in-in in 9.01 Saltbr-in 3.393 HRD-in -74.14, -46.77 73.71, -6.86 in-in-in SNCiii in-in ActLoopNT-in 2.983 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.75, 166.8 APE9-dihe-na 68.75, 148.0 APE8-dihe-in -82.45, 139.06 APE8-rot-in 296.77 APE67-dihe-in -63.19, -13.43 -18.75, -76.87 APE12-dist-in 12.636 APE11-dist-in 10.441 APE10-dist-in 7.678 APE9-dist-in 2.996 None None None XRAY 2.11 0.22 0.26 A 373 354 9 0 0 0 [[158, 706]] 1.0 1q99 Saccharomyces cerevisiae CMGC_SKY1_YEAST CMGC 8.8e-100 339.7 1 301 301 549 550 551 553 555 187 202 206 291 293 292 294 586 574 569 568 567 566 565 564 563 247 Serine/threonine-protein kinase SKY1
CMGC SKY1 SKY1_YEAST 1Q99B Q03656 142 737 742.0 ANP:60902 ATPlike Active DFGin 6.007 13.076 BLAminus -119.51, 178.42 55.8, 73.86 -88.54, 22.76 281.2, 12.04 -67.31, -20.83 in-in in 8.991 Saltbr-in 3.413 HRD-in -77.35, -48.77 76.96, -6.7 in-in-in SNCiii in-in ActLoopNT-in 3.054 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.48, 168.06 APE9-dihe-na 68.34, 160.67 APE8-dihe-in -99.08, 126.68 APE8-rot-in 289.43 APE67-dihe-in -64.6, -22.58 -5.08, -74.37 APE12-dist-in 12.556 APE11-dist-in 10.321 APE10-dist-in 7.788 APE9-dist-in 3.158 None None None XRAY 2.11 0.22 0.26 B 373 364 0 0 0 0 [[158, 706]] 1.0 1q99 Saccharomyces cerevisiae CMGC_SKY1_YEAST CMGC 8.8e-100 339.7 1 301 301 549 550 551 553 555 187 202 206 291 293 292 294 586 574 569 568 567 566 565 564 563 247 Serine/threonine-protein kinase SKY1
OTHER BUD32 BUD32_YEAST 4WW5A P53323 5 257 261.0 ANP:301 Type1.5_Front Active DFGin 6.754 15.371 BLAminus -131.59, 172.16 63.96, 73.04 -100.08, 21.32 284.27, 93.18 -51.84, -32.53 in-in in 7.658 Saltbr-in 2.783 HRD-in -80.73, -50.01 98.03, -11.27 in-in-na SNCiia in-na ActLoopNT-in 2.88 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -64.97, -44.17 APE9-dihe-na -62.31, -41.0 APE8-dihe-na -66.43, -40.1 APE8-rot-na 172.1 APE67-dihe-na -63.36, -39.55 -55.34, -50.01 APE12-dist-na 15.731 APE11-dist-na 11.145 APE10-dist-na 14.707 APE9-dist-na 11.713 None None None XRAY 1.997 0.185 0.222 A 261 236 21 0 0 0 [[17, 261]] 1.0 4ww5 Saccharomyces cerevisiae OTHER_BUD32_YEAST TP53RK 5e-44 156.6 8 224 217 181 182 183 185 187 52 76 80 158 160 159 161 198 204 199 198 197 196 195 194 193 107 EKC/KEOPS complex subunit BUD32
OTHER GCN2-2 GCN2_YEAST 1ZY5A P15442 594 996 1659.0 ANP:60303 ATPlike Inactive DFGin 6.436 13.948 BLBminus -143.1, -168.47 53.69, 51.66 -54.84, 142.33 286.09, 71.25 -76.51, 124.09 out-out out 12.661 Saltbr-out 11.057 HRD-in -67.81, -47.78 76.36, -17.83 out-out-none SNCoon out-none ActLoopNT-out 8.502 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -71.49, -10.61 999.0, -40.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 R794G None None XRAY 2.0 0.235 0.279 A 303 269 31 0 0 25 [[292, 527], [599, 981]] 2.0 1zy5 Saccharomyces cerevisiae OTHER_GCN2-2_YEAST STE 3.9e-47 167.3 1 254 254 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
OTHER GCN2-2 GCN2_YEAST 1ZY5B P15442 594 983 1659.0 ANP:60304 ATPlike Inactive DFGin 6.603 13.914 BLBminus -140.22, -166.87 36.36, 56.71 -49.57, 149.56 284.28, 69.17 -88.92, 120.77 out-out out 12.825 Saltbr-out 9.799 HRD-in -69.22, -51.57 73.48, -3.27 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -57.67 APE8-dihe-out -69.97, -47.08 APE8-rot-out 170.45 APE67-dihe-in -61.67, -26.23 -38.97, -39.82 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.754 R794G None None XRAY 2.0 0.235 0.279 B 303 247 40 0 0 29 [[292, 527], [599, 981]] 2.0 1zy5 Saccharomyces cerevisiae OTHER_GCN2-2_YEAST STE 3.9e-47 167.3 1 254 254 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
AGC PRKACA KAPCA_PIG 1CDKA P36887 9 351 351.0 ANP:60400 ATPlike Active DFGin 5.843 14.33 BLAminus -113.76, -166.2 47.38, 80.03 -85.76, 16.06 278.85, 56.4 -55.46, -28.11 in-in in 9.034 Saltbr-in 2.899 HRD-in -94.66, -56.81 78.16, -3.52 in-in-in SNCiii in-in ActLoopNT-in 2.985 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.51, 155.2 APE9-dihe-na 137.51, -153.75 APE8-dihe-in -125.49, 136.2 APE8-rot-in 297.83 APE67-dihe-in -73.46, -24.38 -35.73, -51.43 APE12-dist-in 7.997 APE11-dist-in 11.418 APE10-dist-in 5.766 APE9-dist-in 3.642 None TPO198 TPO198 XRAY 2.0 0.197 999.0 A 350 343 0 0 0 0 [[44, 298]] 1.0 1cdk Sus scrofa AGC_PRKACA_PIG AGC 3.5e-95 324.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_PIG 1CDKB P36887 9 351 351.0 ANP:60400 ATPlike Active DFGin 5.907 14.511 BLAminus -124.27, -171.72 50.82, 76.29 -83.58, 17.26 280.88, 62.25 -47.74, -29.83 in-in in 8.889 Saltbr-in 2.883 HRD-in -87.48, -57.48 77.49, 1.67 in-in-in SNCiii in-in ActLoopNT-in 2.963 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.91, 159.84 APE9-dihe-na 137.3, -140.74 APE8-dihe-in -136.57, 132.27 APE8-rot-in 304.84 APE67-dihe-in -69.16, -27.96 -34.59, -53.92 APE12-dist-in 8.348 APE11-dist-in 11.514 APE10-dist-in 6.08 APE9-dist-in 3.744 None TPO198 TPO198 XRAY 2.0 0.197 999.0 B 350 343 0 0 0 0 [[44, 298]] 1.0 1cdk Sus scrofa AGC_PRKACA_PIG AGC 3.5e-95 324.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
OTHER RNASEL A5H025_PIG 4O1PA A5H025 22 729 743.0 ANP:901,25L:904 ATPlike,Allosteric Inactive DFGin 6.511 12.96 ABAminus -131.33, -33.02 -113.57, 101.31 -107.24, 17.35 306.62, 95.87 -64.46, -18.71 in-in in 7.025 Saltbr-in 2.559 HRD-in -60.39, -60.51 77.09, -8.47 in-in-na SNCiia in-na ActLoopNT-in 2.832 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -142.96, 83.14 APE9-dihe-na -58.16, -26.45 APE8-dihe-na -61.31, -25.89 APE8-rot-na 201.37 APE67-dihe-na -54.23, -32.66 -72.61, -17.63 APE12-dist-na 15.865 APE11-dist-na 12.959 APE10-dist-na 13.132 APE9-dist-na 13.867 None None None XRAY 2.5 0.198 0.231 A 717 672 4 0 0 0 [[351, 591]] 1.0 4o1p Sus scrofa OTHER_RNASEL_PIG RNASEL 2.2e-128 433.7 1 242 242 499 500 501 503 505 390 402 406 479 481 480 482 517 519 514 513 512 511 510 509 508 433 Ribonuclease L
OTHER RNASEL A5H025_PIG 4O1PB A5H025 22 729 743.0 ANP:901,25L:904 ATPlike,Allosteric Inactive DFGin 6.558 12.933 ABAminus -131.25, -34.01 -112.79, 101.17 -107.11, 16.68 306.49, 96.02 -64.91, -18.59 in-in in 7.035 Saltbr-in 2.561 HRD-in -55.77, -50.97 68.09, -3.12 in-in-na SNCiia in-na ActLoopNT-in 2.869 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -144.24, 83.66 APE9-dihe-na -56.74, -27.11 APE8-dihe-na -62.19, -25.6 APE8-rot-na 202.01 APE67-dihe-na -55.19, -32.83 -72.11, -17.43 APE12-dist-na 15.838 APE11-dist-na 12.884 APE10-dist-na 13.127 APE9-dist-na 13.69 None None None XRAY 2.5 0.198 0.231 B 717 671 3 0 0 0 [[351, 591]] 1.0 4o1p Sus scrofa OTHER_RNASEL_PIG RNASEL 2.2e-128 433.7 1 242 242 499 500 501 503 505 390 402 406 479 481 480 482 517 519 514 513 512 511 510 509 508 433 Ribonuclease L
OTHER RNASEL A5H025_PIG 4O1PC A5H025 22 729 743.0 ANP:901,25L:904 ATPlike,Allosteric Inactive DFGin 6.574 12.951 ABAminus -131.64, -33.31 -113.88, 102.15 -109.17, 16.76 306.25, 95.79 -63.9, -18.81 in-in in 7.036 Saltbr-in 2.556 HRD-in -57.15, -62.34 78.43, -4.0 in-in-na SNCiia in-na ActLoopNT-in 2.84 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -142.78, 82.89 APE9-dihe-na -56.9, -26.71 APE8-dihe-na -61.49, -26.14 APE8-rot-na 201.42 APE67-dihe-na -54.45, -32.57 -72.46, -17.58 APE12-dist-na 15.874 APE11-dist-na 12.972 APE10-dist-na 13.122 APE9-dist-na 13.707 None None None XRAY 2.5 0.198 0.231 C 717 673 4 0 0 0 [[351, 591]] 1.0 4o1p Sus scrofa OTHER_RNASEL_PIG RNASEL 2.2e-128 433.7 1 242 242 499 500 501 503 505 390 402 406 479 481 480 482 517 519 514 513 512 511 510 509 508 433 Ribonuclease L
OTHER RNASEL A5H025_PIG 4O1PD A5H025 22 729 743.0 ANP:901,25L:904 ATPlike,Allosteric Inactive DFGin 6.522 12.918 ABAminus -132.11, -32.85 -113.92, 101.55 -106.16, 16.67 306.88, 96.47 -66.56, -17.9 in-in in 7.025 Saltbr-in 2.558 HRD-in -66.2, -51.02 69.27, -3.45 in-in-na SNCiia in-na ActLoopNT-in 2.837 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -143.98, 84.27 APE9-dihe-na -56.61, -27.19 APE8-dihe-na -61.86, -25.69 APE8-rot-na 201.6 APE67-dihe-na -54.63, -32.79 -72.23, -18.0 APE12-dist-na 15.813 APE11-dist-na 12.795 APE10-dist-na 13.098 APE9-dist-na 13.604 None None None XRAY 2.5 0.198 0.231 D 717 668 5 0 0 0 [[351, 591]] 1.0 4o1p Sus scrofa OTHER_RNASEL_PIG RNASEL 2.2e-128 433.7 1 242 242 499 500 501 503 505 390 402 406 479 481 480 482 517 519 514 513 512 511 510 509 508 433 Ribonuclease L
OTHER TCUR0376 D1A2F7_THECD 8CAVA D1A2F7 6 865 865.0 ANP:61003 Allosteric Inactive DFGout 25.029 13.806 None -136.61, -176.07 50.55, 90.07 -109.52, 39.53 298.71, 97.0 -61.52, -45.79 out-na out 23.304 Saltbr-na 999.0 HRD-in -69.88, -46.85 69.44, -25.22 na-in-out SNCaio in-out ActLoopNT-in 3.046 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na 151.19, 133.67 APE9-dihe-na -156.32, 163.61 APE8-dihe-in -115.94, 119.26 APE8-rot-in 286.11 APE67-dihe-inflip 85.43, -34.6 -53.57, 131.45 APE12-dist-out 4.165 APE11-dist-in 8.343 APE10-dist-in 6.311 APE9-dist-in 5.642 None None None XRAY 2.87 0.24 0.293 A 865 860 0 0 0 0 [[216, 447]] 1.0 8cav Thermomonospora curvata OTHER_TCUR0376_THECD OTHER 2.3e-11 51.4 3 202 200 367 368 369 371 373 245 255 255 346 348 347 349 402 390 385 384 383 382 381 380 379 255 Serine/threonine protein kinase
OTHER TCUR0376 D1A2F7_THECD 8CAVB D1A2F7 6 863 865.0 ANP:61102 Allosteric Inactive DFGout 25.219 13.273 None -136.17, 0.21 -151.94, 106.25 -116.71, 46.61 337.45, 77.06 -61.98, -44.38 out-na out 23.216 Saltbr-na 999.0 HRD-in -72.63, -51.39 72.73, -38.34 na-in-out SNCaio in-out ActLoopNT-in 3.126 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na 155.97, 136.86 APE9-dihe-na -156.68, 147.71 APE8-dihe-in -106.12, 118.89 APE8-rot-in 302.92 APE67-dihe-inflip 84.82, -43.75 -50.92, 139.58 APE12-dist-out 4.031 APE11-dist-in 8.215 APE10-dist-in 6.529 APE9-dist-in 5.969 None None None XRAY 2.87 0.24 0.293 B 865 858 0 0 0 0 [[216, 447]] 1.0 8cav Thermomonospora curvata OTHER_TCUR0376_THECD OTHER 2.3e-11 51.4 3 202 200 367 368 369 371 373 245 255 255 346 348 347 349 402 390 385 384 383 382 381 380 379 255 Serine/threonine protein kinase
CAMK CDPK1 Q9BJF5_TOXGO 4IEBA Q9BJF5 32 507 507.0 ANP:60605 ATPlike Inactive DFGin 6.554 15.761 BLAminus -118.12, -178.54 57.22, 81.05 -93.39, 22.31 283.83, 75.07 -62.91, -21.06 out-out out 10.786 Saltbr-out 8.183 HRD-in -78.1, -52.4 75.27, -1.01 out-in-in SNCoii in-in ActLoopNT-in 2.972 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.38, 132.65 APE9-dihe-na 150.75, -159.18 APE8-dihe-in -127.81, 136.94 APE8-rot-in 296.09 APE67-dihe-in -59.35, -29.22 -49.66, -52.18 APE12-dist-in 8.747 APE11-dist-in 11.876 APE10-dist-in 6.073 APE9-dist-in 3.686 G128M None None XRAY 2.05 0.176 0.217 A 515 471 4 0 0 0 [[51, 308]] 1.0 4ieb Toxoplasma gondii CAMK_CDPK1_TOXGO CAMK 1.4e-91 312.8 1 256 256 194 195 196 198 200 80 99 103 171 173 172 174 232 221 216 215 214 213 212 211 210 129 non-specific serine/threonine protein kinase
CAMK CDPK1 Q9BJF5_TOXGO 3HX4A Q9BJF5 30 503 507.0 ANP:605 ATPlike Inactive DFGin 6.376 15.597 BLAminus -124.93, -178.11 57.55, 76.18 -93.17, 21.06 281.41, 72.38 -57.25, -28.44 out-out out 10.43 Saltbr-out 8.082 HRD-in -82.41, -52.5 74.03, -1.03 out-in-in SNCoii in-in ActLoopNT-in 2.926 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.23, 136.25 APE9-dihe-na 150.35, -156.09 APE8-dihe-in -126.64, 138.87 APE8-rot-in 302.17 APE67-dihe-in -62.12, -29.95 -51.48, -47.24 APE12-dist-in 8.582 APE11-dist-in 12.055 APE10-dist-in 6.188 APE9-dist-in 3.646 None None None XRAY 1.95 0.212 0.257 A 508 467 7 0 0 0 [[51, 308]] 1.0 3hx4 Toxoplasma gondii CAMK_CDPK1_TOXGO CAMK 5.2e-90 307.5 1 256 256 194 195 196 198 200 80 99 103 171 173 172 174 232 221 216 215 214 213 212 211 210 129 non-specific serine/threonine protein kinase
CAMK CDPK1 Q9BJF5_TOXGO 3KU2A Q9BJF5 44 507 507.0 ANP:508 ATPlike Inactive None 11.477 17.939 None -100.99, 156.17 73.53, 18.21 -64.25, 133.09 244.39, 100.2 75.66, -4.53 out-none out 14.497 Saltbr-none 999.0 HRD-in -80.49, -57.8 77.94, -40.26 none-out-out SNCnoo out-out ActLoopNT-out 5.721 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -61.85, 129.57 APE9-dihe-na 74.83, 23.66 APE8-dihe-out -106.17, -37.64 APE8-rot-out 63.52 APE67-dihe-in -62.81, -37.67 -61.55, -28.62 APE12-dist-out 14.055 APE11-dist-out 16.655 APE10-dist-out 19.069 APE9-dist-out 12.042 None None None XRAY 2.3 0.198 0.236 A 507 457 0 0 0 0 [[51, 308]] 1.0 3ku2 Toxoplasma gondii CAMK_CDPK1_TOXGO CAMK 5.2e-90 307.5 1 256 256 194 195 196 198 200 80 99 103 171 173 172 174 232 221 216 215 214 213 212 211 210 129 non-specific serine/threonine protein kinase
OTHER ROP18 ROP18_TOXGO 4JRNA Q2PAY2 187 548 554.0 ANP:601 Allosteric None DFGin 8.982 15.869 BLAminus -128.68, -167.44 58.76, 57.13 -87.53, 25.8 281.08, 82.06 -67.92, -21.93 in-in in 8.183 Saltbr-in 2.992 HRD-in -70.13, -31.0 63.02, -2.32 in-in-none SNCiin in-none ActLoopNT-in 2.384 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_inni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 178.51 APE8-dihe-in -78.23, 127.04 APE8-rot-in 289.7 APE67-dihe-inflip 110.21, -8.27 -63.71, 127.69 APE12-dist-in 10.007 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.276 None None None XRAY 2.71 0.235 0.289 A 372 349 6 0 0 2 [[253, 531]] 1.0 4jrn Toxoplasma gondii OTHER_ROP18_TOXGO CAMK 0.04 76.6 5 55 197 426 427 428 430 432 281 300 304 406 408 407 409 465 450 445 444 443 442 441 440 439 0 Serine/threonine-protein kinase ROP18
OTHER PINK1 PINK1_TRICA 5YJ9D D6WMX4 166 570 570.0 ANP:601 ATPlike Inactive DFGin 9.502 15.283 ABAminus -117.37, -38.64 -95.18, 97.77 -99.2, 13.92 280.74, 77.89 -62.77, -17.79 in-in in 7.836 Saltbr-in 2.58 HRD-out -70.37, 137.63 -130.59, 22.41 in-in-out SNCiio in-out ActLoopNT-in 2.579 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_iiii APE10-dihe-na -154.61, -176.52 APE9-dihe-na -54.92, 113.48 APE8-dihe-in -53.26, 148.57 APE8-rot-na 309.64 APE67-dihe-out -106.62, -9.97 -172.9, 165.52 APE12-dist-in 7.975 APE11-dist-in 11.272 APE10-dist-in 7.159 APE9-dist-in 3.217 S205D,S377D,T386E,T530E None MSE197,MSE198,MSE208,MSE214,MSE223,MSE288,MSE294,MSE328,MSE380,MSE389 XRAY 2.53 0.23 0.243 D 423 343 56 0 0 0 [[61, 504]] 1.0 5yj9 Tribolium castaneum OTHER_PINK1_TRICA PINK1 5.8e-86 294.6 5 367 363 358 359 360 362 364 196 217 221 334 336 335 337 410 392 387 386 385 384 383 382 381 295 Serine/threonine-protein kinase Pink1, mitochondrial
CMGC TVAG125560 A2F9N1_TRIV3 9AV7A A2F9N1 15 318 320.0 ANP:401 ATPlike Active DFGin 7.636 16.424 BLAminus -120.42, -177.29 61.53, 69.44 -89.47, 18.08 296.84, 80.84 -66.47, -28.11 in-in in 9.462 Saltbr-in 3.092 HRD-in -77.85, -46.91 69.04, 9.93 in-in-in SNCiii in-in ActLoopNT-in 2.954 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.39, -177.21 APE9-dihe-na 62.4, -175.9 APE8-dihe-in -115.65, 153.97 APE8-rot-in 297.25 APE67-dihe-inflip 82.79, -6.3 -53.46, 134.7 APE12-dist-in 12.695 APE11-dist-in 10.496 APE10-dist-in 6.317 APE9-dist-in 3.013 None None None XRAY 2.1 0.202 0.246 A 328 304 0 0 0 0 [[27, 312]] 1.0 9av7 Trichomonas vaginalis CMGC_TVAG125560_TRIV3 CMGC 2.3e-51 180.8 1 301 301 162 163 164 166 168 56 69 73 141 143 142 144 202 189 184 183 182 181 180 179 178 102 non-specific serine/threonine protein kinase
CAMK AURKBA AUKBA_XENLA 4C2WA Q6DE08 88 356 361.0 ANP:1001 ATPlike Inactive DFGin 5.524 15.79 ABAminus -114.94, -31.28 -113.37, 121.43 -114.18, 23.33 282.52, 84.1 -51.89, -43.92 out-out out 11.268 Saltbr-out 4.973 HRD-in -79.83, -53.41 73.71, 4.05 out-in-in SNCoii in-in ActLoopNT-in 2.893 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.21, 165.55 APE9-dihe-na 112.48, -144.66 APE8-dihe-in -138.33, 133.06 APE8-rot-in 294.04 APE67-dihe-in -66.35, -18.01 -34.41, -59.11 APE12-dist-in 8.359 APE11-dist-in 10.941 APE10-dist-in 5.531 APE9-dist-in 3.561 None TPO248 TPO248 XRAY 1.7 0.158 0.195 A 279 269 0 0 0 0 [[93, 343]] 1.0 4c2w Xenopus laevis CAMK_AURKBA_XENLA CAMK 2.3e-77 265.7 1 256 256 233 234 235 237 239 122 141 145 213 215 214 216 271 259 254 253 252 251 250 249 248 171 Aurora kinase B-A
CAMK AURKBA AUKBA_XENLA 4C2WB Q6DE08 78 355 361.0 ANP:1002 ATPlike Inactive DFGin 5.81 15.787 ABAminus -118.01, -19.02 -130.42, 119.39 -114.99, 28.58 284.95, 75.85 -64.5, -21.38 out-out out 10.763 Saltbr-out 4.74 HRD-in -76.03, -52.74 71.93, -3.36 out-in-in SNCoii in-in ActLoopNT-in 2.919 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.86, 167.53 APE9-dihe-na 123.0, -151.95 APE8-dihe-in -138.83, 132.09 APE8-rot-in 301.48 APE67-dihe-in -63.95, -21.5 -45.73, -54.15 APE12-dist-in 8.042 APE11-dist-in 10.769 APE10-dist-in 5.323 APE9-dist-in 3.606 None TPO248 TPO248 XRAY 1.7 0.158 0.195 B 279 278 0 0 0 0 [[93, 343]] 1.0 4c2w Xenopus laevis CAMK_AURKBA_XENLA CAMK 2.3e-77 265.7 1 256 256 233 234 235 237 239 122 141 145 213 215 214 216 271 259 254 253 252 251 250 249 248 171 Aurora kinase B-A
CMGC ACK2 CSK2A_MAIZE 1DAWA P28523 2 328 332.0 ANP:60340 ATPlike Inactive DFGin 7.479 16.253 BLAminus -105.07, -177.02 59.3, 78.28 -93.62, 17.81 300.8, 85.23 -64.69, -25.71 in-in in 9.044 Saltbr-in 2.614 HRD-in -71.54, -56.91 74.99, 12.33 in-in-out SNCiio in-out ActLoopNT-in 2.653 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -145.67, 164.1 APE9-dihe-na 63.95, 166.03 APE8-dihe-in -78.9, 151.56 APE8-rot-out 157.17 APE67-dihe-in -65.06, -18.37 -51.17, -45.02 APE12-dist-in 12.458 APE11-dist-in 10.113 APE10-dist-in 6.017 APE9-dist-in 3.096 None None None XRAY 2.2 0.223 0.285 A 327 327 0 0 0 0 [[34, 319]] 1.0 1daw Zea mays CMGC_ACK2_MAIZE CMGC 1.7e-65 227.1 1 301 301 169 170 171 173 175 63 76 80 148 150 149 151 209 196 191 190 189 188 187 186 185 109 Casein kinase II subunit alpha
CMGC ACK2 CSK2A_MAIZE 1LP4A P28523 2 328 332.0 ANP:60340 ATPlike Inactive DFGin 7.384 16.437 BLAminus -105.48, -174.19 57.32, 75.68 -95.1, 15.33 299.18, 80.31 -67.7, -16.27 in-in in 8.951 Saltbr-in 2.929 HRD-in -74.21, -49.64 68.44, 10.87 in-in-out SNCiio in-out ActLoopNT-in 2.792 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.52, 168.08 APE9-dihe-na 65.54, 161.64 APE8-dihe-in -72.4, 142.48 APE8-rot-out 152.04 APE67-dihe-in -70.58, -15.11 -42.33, -45.49 APE12-dist-in 12.411 APE11-dist-in 10.041 APE10-dist-in 6.036 APE9-dist-in 3.138 None None None XRAY 1.86 0.207 0.244 A 332 327 0 0 0 0 [[34, 319]] 1.0 1lp4 Zea mays CMGC_ACK2_MAIZE CMGC 1.8e-65 227.0 1 301 301 169 170 171 173 175 63 76 80 148 150 149 151 209 196 191 190 189 188 187 186 185 109 Casein kinase II subunit alpha
OTHER SIRK1 K7VIQ3_MAIZE 5UV4A K7VIQ3 744 1045 1045.0 ANP:1101 ATPlike Pseudo DFGin 4.878 12.802 BLBplus -120.34, 177.7 46.93, 54.84 -91.14, 142.45 62.71, 98.99 59.6, 31.25 out-out out 15.147 Saltbr-out 17.532 HRD-in -68.43, -62.74 80.25, -5.53 out-out-out SNCooo out-out ActLoopNT-out 7.16 ActLoopCT-out nonTYR APEdihe_aaono APEdist_oioo APE10-dihe-na -63.26, -37.61 APE9-dihe-na -61.51, -44.79 APE8-dihe-out -63.05, -40.24 APE8-rot-none 999.0 APE67-dihe-out 86.33, 22.47 -82.94, -6.82 APE12-dist-out 14.657 APE11-dist-in 12.436 APE10-dist-out 11.85 APE9-dist-out 10.422 None None None XRAY 2.3 0.184 0.211 A 311 290 12 0 0 0 [[757, 1042]] 1.0 5uv4 Zea mays OTHER_SIRK1_MAIZE TKL 1.6e-38 138.7 5 265 261 906 907 908 910 912 789 805 809 885 887 886 888 949 935 930 929 928 927 926 925 924 837 Putative leucine-rich repeat protein kinase family protein