TGFBR2 (TGF-beta receptor type-2)

Group: TKL
Uniprot: TGFR2_HUMAN
Domain boundary: 244 - 540


Total number of chains: 8
Spatial Dihedral Chains Representative
DFGin BLAminus 7 AF-P37173-K1A
DFGin ABAminus 1 5E8YA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
5E8YA 2.05 Inactive DFGin ABAminus in-in in-in STU Type1 240 - 541 E431A,R433A,E485A,K488A,R493A,R495A None 0
AF-P37173-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 236 - 548 None None 0
8YGZA 2.1 Active DFGin BLAminus in-in in-in No_ligand No_ligand 240 - 541 None None 4
5E8VA 1.69 Active DFGin BLAminus in-in in-in No_ligand No_ligand 240 - 541 E431A,R433A,E485A,K488A,R493A,R495A None 0
5E91A 2.42 Active DFGin BLAminus in-in in-in 5L4 Type1 240 - 543 E431A,R433A,E485A,K488A,R493A,R495A None 0
5E92A 2.08 Active DFGin BLAminus in-in in-in ANP Type1 240 - 543 E431A,R433A,E485A,K488A,R493A,R495A None 0
5QINA 1.57 Active DFGin BLAminus in-in in-in J2V Type1 240 - 541 E431A,R433A,E485A,K488A,R493A,R495A None 2
7DV6A 2.39 Active DFGin BLAminus in-in in-in HJF Type1 240 - 543 E431A,R433A,E485A,K488A,R493A,R495A None 0

TGFBR2 (TGF-beta receptor type-2)

Group: TKL
Total number of chains: 8
Spatial Dihedral Chains Representative
DFGin BLAminus 7 AF-P37173-K1A
DFGin ABAminus 1 5E8YA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens TGFR2_HUMAN 5E8YA 2.05 Inactive DFGin ABAminus in-in in-in STU Type1 240 - 541 E431A,R433A,E485A,K488A,R493A,R495A None 0
Homo sapiens TGFR2_HUMAN AF-P37173-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 236 - 548 None None 0
Homo sapiens TGFR2_HUMAN 8YGZA 2.1 Active DFGin BLAminus in-in in-in No_ligand No_ligand 240 - 541 None None 4
Homo sapiens TGFR2_HUMAN 5E8VA 1.69 Active DFGin BLAminus in-in in-in No_ligand No_ligand 240 - 541 E431A,R433A,E485A,K488A,R493A,R495A None 0
Homo sapiens TGFR2_HUMAN 5E91A 2.42 Active DFGin BLAminus in-in in-in 5L4 Type1 240 - 543 E431A,R433A,E485A,K488A,R493A,R495A None 0
Homo sapiens TGFR2_HUMAN 5E92A 2.08 Active DFGin BLAminus in-in in-in ANP Type1 240 - 543 E431A,R433A,E485A,K488A,R493A,R495A None 0
Homo sapiens TGFR2_HUMAN 5QINA 1.57 Active DFGin BLAminus in-in in-in J2V Type1 240 - 541 E431A,R433A,E485A,K488A,R493A,R495A None 2
Homo sapiens TGFR2_HUMAN 7DV6A 2.39 Active DFGin BLAminus in-in in-in HJF Type1 240 - 543 E431A,R433A,E485A,K488A,R493A,R495A None 0

TGFBR2 (TGF-beta receptor type-2)

No non-human structures known.