TKL_TGFBR2 (TGF-beta receptor type-2)

Total number of chains: 9
Active chains: 7
Uniprot: TGFR2_HUMAN
Kinase Domain Residues: 244 - 540
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 8 88.9% AF-P37173-K1A
DFGin ABAminus 1 11.1% 5E8YA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
5E92A 2.08 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 240 - 543 0 None E431A,R433A,E485A,K488A,R493A,R495A TGF-beta receptor type-2
AF-P37173-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 236 - 548 0 None None TGF-beta receptor type-2
AF-P37173-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 236 - 548 0 None None TGF-beta receptor type-2
8YGZA 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 240 - 541 0 None None TGF-beta receptor type-2
5E8VA 1.69 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 240 - 541 0 None E431A,R433A,E485A,K488A,R493A,R495A TGF-beta receptor type-2
5E91A 2.42 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5L4 Type1 240 - 543 0 None E431A,R433A,E485A,K488A,R493A,R495A TGF-beta receptor type-2
7DV6A 2.39 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii HJF Type1 240 - 543 0 None E431A,R433A,E485A,K488A,R493A,R495A TGF-beta receptor type-2
5E8YA 2.05 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 240 - 541 0 None E431A,R433A,E485A,K488A,R493A,R495A TGF-beta receptor type-2
5QINA 1.57 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_niii J2V Type1 240 - 541 0 None E431A,R433A,E485A,K488A,R493A,R495A TGF-beta receptor type-2

TKL_TGFBR2 (TGF-beta receptor type-2)

Total number of chains: 9
Active chains: 7
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 8 88.9% AF-P37173-K1A
DFGin ABAminus 1 11.1% 5E8YA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TGFR2_HUMAN 5E92A 2.08 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 240 - 543 0 None E431A,R433A,E485A,K488A,R493A,R495A TGF-beta receptor type-2 Homo sapiens
TGFR2_HUMAN AF-P37173-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 236 - 548 0 None None TGF-beta receptor type-2 Homo sapiens
TGFR2_HUMAN AF-P37173-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 236 - 548 0 None None TGF-beta receptor type-2 Homo sapiens
TGFR2_HUMAN 8YGZA 2.1 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 240 - 541 0 None None TGF-beta receptor type-2 Homo sapiens
TGFR2_HUMAN 5E8VA 1.69 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 240 - 541 0 None E431A,R433A,E485A,K488A,R493A,R495A TGF-beta receptor type-2 Homo sapiens
TGFR2_HUMAN 5E91A 2.42 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 5L4 Type1 240 - 543 0 None E431A,R433A,E485A,K488A,R493A,R495A TGF-beta receptor type-2 Homo sapiens
TGFR2_HUMAN 7DV6A 2.39 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii HJF Type1 240 - 543 0 None E431A,R433A,E485A,K488A,R493A,R495A TGF-beta receptor type-2 Homo sapiens
TGFR2_HUMAN 5E8YA 2.05 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii STU Type1 240 - 541 0 None E431A,R433A,E485A,K488A,R493A,R495A TGF-beta receptor type-2 Homo sapiens
TGFR2_HUMAN 5QINA 1.57 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_niii J2V Type1 240 - 541 0 None E431A,R433A,E485A,K488A,R493A,R495A TGF-beta receptor type-2 Homo sapiens

TKL_TGFBR2 (TGF-beta receptor type-2)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism