CDK9 (Cyclin-dependent kinase 9)

Group: CMGC
Uniprot: CDK9_HUMAN
Domain boundary: 19 - 315


Total number of chains: 34
Spatial Dihedral Chains Representative
DFGin BLAminus 34 AF-P50750-K1A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-P50750-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 11 - 323 None None 0
4OR5A 2.9 Active DFGin BLAminus in-in in-in No_ligand No_ligand 8 - 331 None X186 0
4OR5F 2.9 Active DFGin BLAminus in-in in-in No_ligand No_ligand 8 - 332 None X186 0
5L1ZA 5.9 Active DFGin BLAminus in-in in-in No_ligand No_ligand 8 - 330 None X186 0
3BLHA 2.48 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 8 - 325 None X186 5
3TNIA 3.234 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 7 - 325 None X186 6
6CYTA 3.5 Active DFGin BLAminus in-in in-in No_ligand No_ligand 8 - 330 None X186 0
3MI9A 2.1 Active DFGin BLAminus in-in in-in No_ligand No_ligand 8 - 344 None X186 0
4EC8A 3.6 Active DFGin BLAminus in-in in-in No_ligand No_ligand 6 - 338 None X186 0
4EC9A 3.21 Active DFGin BLAminus in-in in-in No_ligand No_ligand 7 - 327 None X186 0
4BCFA 3.011 Active DFGin BLAminus in-in in-in T6Q Type1 6 - 326 None X186 5
8I0LA 3.6 Active DFGin BLAminus in-in in-in NJ6 Type1 6 - 326 None X186 5
6GZHA 3.17 Active DFGin BLAminus in-in in-in LCI Type1 8 - 326 None X186 3
7NWKA 2.81 Active DFGin BLAminus in-in in-in UT5 Type1 7 - 326 None X186 5
3BLQA 2.9 Active DFGin BLAminus in-in in-in ATP Type1 7 - 325 None X186 7
3BLRA 2.8 Active DFGin BLAminus in-in in-in CPB Type1 7 - 326 None X186 4
3LQ5A 3.0 Active DFGin BLAminus in-in in-in SLQ Type1 6 - 327 None X186 4
3MY1A 2.8 Active DFGin BLAminus in-in in-in RFZ Type1 6 - 327 None X186 0
3TN8A 2.95 Active DFGin BLAminus in-in in-in F18 Type1 8 - 325 None X186 4
3TNHA 3.202 Active DFGin BLAminus in-in in-in F18 Type1 8 - 328 None X186 7
4BCGA 3.085 Inactive DFGin BLAminus in-out in-in T3C Type1 7 - 327 None X186 0
4BCHA 2.958 Inactive DFGin BLAminus in-out in-in T7Z Type1 7 - 327 None X186 5
4BCIA 3.1 Inactive DFGin BLAminus in-out in-in T3E Type1 5 - 326 None X186 4
4BCJA 3.162 Inactive DFGin BLAminus in-out in-in T9N Type1 6 - 326 None X186 4
4IMYC 2.94 Active DFGin BLAminus in-in in-in AMP Type1 8 - 330 None X186 0
4IMYE 2.94 Active DFGin BLAminus in-in in-in AMP Type1 8 - 330 None X186 0
4OGRA 3.0 Active DFGin BLAminus in-in in-in ADN Type1 8 - 330 None X186 0
4OGRE 3.0 Active DFGin BLAminus in-in in-in ADN Type1 8 - 330 None X186 0
4OGRI 3.0 Active DFGin BLAminus in-in in-in ADN Type1 8 - 330 None X186 0
8K5RA 3.751 Inactive DFGin BLAminus in-out in-in VQE Type1 5 - 327 S7D,V8N,K44R,Y138F,K280A,D307E,N311E X186 3
3MIAA 3.0 Active DFGin BLAminus in-in in-in ANP Type1 8 - 340 None X186 0
6Z45A 3.37 Active DFGin BLAminus in-in in-in Q6E Type1 5 - 328 None X186 4
6W9EA 3.1 Active DFGin BLAminus in-in in-in TO7 TO7 TOJ TOJ Type1 Type1 Type1 Type1 7 - 326 None X186,X306 4
4IMYA 2.94 Active DFGin BLAminus in-in in-in AMP Type1.5_Back 8 - 330 None X186 0

CDK9 (Cyclin-dependent kinase 9)

Group: CMGC
Total number of chains: 34
Spatial Dihedral Chains Representative
DFGin BLAminus 34 AF-P50750-K1A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens CDK9_HUMAN AF-P50750-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 11 - 323 None None 0
Homo sapiens CDK9_HUMAN 4OR5A 2.9 Active DFGin BLAminus in-in in-in No_ligand No_ligand 8 - 331 None X186 0
Homo sapiens CDK9_HUMAN 4OR5F 2.9 Active DFGin BLAminus in-in in-in No_ligand No_ligand 8 - 332 None X186 0
Homo sapiens CDK9_HUMAN 5L1ZA 5.9 Active DFGin BLAminus in-in in-in No_ligand No_ligand 8 - 330 None X186 0
Homo sapiens CDK9_HUMAN 3BLHA 2.48 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 8 - 325 None X186 5
Homo sapiens CDK9_HUMAN 3TNIA 3.234 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 7 - 325 None X186 6
Homo sapiens CDK9_HUMAN 6CYTA 3.5 Active DFGin BLAminus in-in in-in No_ligand No_ligand 8 - 330 None X186 0
Homo sapiens CDK9_HUMAN 3MI9A 2.1 Active DFGin BLAminus in-in in-in No_ligand No_ligand 8 - 344 None X186 0
Homo sapiens CDK9_HUMAN 4EC8A 3.6 Active DFGin BLAminus in-in in-in No_ligand No_ligand 6 - 338 None X186 0
Homo sapiens CDK9_HUMAN 4EC9A 3.21 Active DFGin BLAminus in-in in-in No_ligand No_ligand 7 - 327 None X186 0
Homo sapiens CDK9_HUMAN 4BCFA 3.011 Active DFGin BLAminus in-in in-in T6Q Type1 6 - 326 None X186 5
Homo sapiens CDK9_HUMAN 8I0LA 3.6 Active DFGin BLAminus in-in in-in NJ6 Type1 6 - 326 None X186 5
Homo sapiens CDK9_HUMAN 6GZHA 3.17 Active DFGin BLAminus in-in in-in LCI Type1 8 - 326 None X186 3
Homo sapiens CDK9_HUMAN 7NWKA 2.81 Active DFGin BLAminus in-in in-in UT5 Type1 7 - 326 None X186 5
Homo sapiens CDK9_HUMAN 3BLQA 2.9 Active DFGin BLAminus in-in in-in ATP Type1 7 - 325 None X186 7
Homo sapiens CDK9_HUMAN 3BLRA 2.8 Active DFGin BLAminus in-in in-in CPB Type1 7 - 326 None X186 4
Homo sapiens CDK9_HUMAN 3LQ5A 3.0 Active DFGin BLAminus in-in in-in SLQ Type1 6 - 327 None X186 4
Homo sapiens CDK9_HUMAN 3MY1A 2.8 Active DFGin BLAminus in-in in-in RFZ Type1 6 - 327 None X186 0
Homo sapiens CDK9_HUMAN 3TN8A 2.95 Active DFGin BLAminus in-in in-in F18 Type1 8 - 325 None X186 4
Homo sapiens CDK9_HUMAN 3TNHA 3.202 Active DFGin BLAminus in-in in-in F18 Type1 8 - 328 None X186 7
Homo sapiens CDK9_HUMAN 4BCGA 3.085 Inactive DFGin BLAminus in-out in-in T3C Type1 7 - 327 None X186 0
Homo sapiens CDK9_HUMAN 4BCHA 2.958 Inactive DFGin BLAminus in-out in-in T7Z Type1 7 - 327 None X186 5
Homo sapiens CDK9_HUMAN 4BCIA 3.1 Inactive DFGin BLAminus in-out in-in T3E Type1 5 - 326 None X186 4
Homo sapiens CDK9_HUMAN 4BCJA 3.162 Inactive DFGin BLAminus in-out in-in T9N Type1 6 - 326 None X186 4
Homo sapiens CDK9_HUMAN 4IMYC 2.94 Active DFGin BLAminus in-in in-in AMP Type1 8 - 330 None X186 0
Homo sapiens CDK9_HUMAN 4IMYE 2.94 Active DFGin BLAminus in-in in-in AMP Type1 8 - 330 None X186 0
Homo sapiens CDK9_HUMAN 4OGRA 3.0 Active DFGin BLAminus in-in in-in ADN Type1 8 - 330 None X186 0
Homo sapiens CDK9_HUMAN 4OGRE 3.0 Active DFGin BLAminus in-in in-in ADN Type1 8 - 330 None X186 0
Homo sapiens CDK9_HUMAN 4OGRI 3.0 Active DFGin BLAminus in-in in-in ADN Type1 8 - 330 None X186 0
Homo sapiens CDK9_HUMAN 8K5RA 3.751 Inactive DFGin BLAminus in-out in-in VQE Type1 5 - 327 S7D,V8N,K44R,Y138F,K280A,D307E,N311E X186 3
Homo sapiens CDK9_HUMAN 3MIAA 3.0 Active DFGin BLAminus in-in in-in ANP Type1 8 - 340 None X186 0
Homo sapiens CDK9_HUMAN 6Z45A 3.37 Active DFGin BLAminus in-in in-in Q6E Type1 5 - 328 None X186 4
Homo sapiens CDK9_HUMAN 6W9EA 3.1 Active DFGin BLAminus in-in in-in TO7 TO7 TOJ TOJ Type1 Type1 Type1 Type1 7 - 326 None X186,X306 4
Homo sapiens CDK9_HUMAN 4IMYA 2.94 Active DFGin BLAminus in-in in-in AMP Type1.5_Back 8 - 330 None X186 0

CDK9 (Cyclin-dependent kinase 9)

No non-human structures known.