CMGC_MAPK12 (Mitogen-activated protein kinase 12)

Total number of chains: 10
Active chains: 4
Uniprot: MK12_HUMAN
Kinase Domain Residues: 27 - 311
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 50.0% AF-P53778-K1A
DFGin ABAminus 3 30.0% 7CGAB
DFGin BLBplus 2 20.0% 6UNAA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
1CM8A 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 8 - 353 0 TPO183,PTR185 None Mitogen-activated protein kinase 12
1CM8B 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 8 - 353 0 TPO183,PTR185 None Mitogen-activated protein kinase 12
AF-P53778-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 19 - 319 0 None None Mitogen-activated protein kinase 12
AF-P53778-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 19 - 319 0 None None Mitogen-activated protein kinase 12
7CGAB 3.15 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiio No_ligand No_ligand 9 - 353 0 None None Mitogen-activated protein kinase 12
7CGAC 3.15 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiio No_ligand No_ligand 9 - 353 0 None None Mitogen-activated protein kinase 12
7CGAD 3.15 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiio No_ligand No_ligand 9 - 353 0 None None Mitogen-activated protein kinase 12
7CGAA 3.15 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiio No_ligand No_ligand 9 - 353 0 None None Mitogen-activated protein kinase 12
6UNAA 2.554 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 10 - 351 0 None Q31R Mitogen-activated protein kinase 12
6UNAB 2.554 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 9 - 351 0 None Q31R Mitogen-activated protein kinase 12

CMGC_MAPK12 (Mitogen-activated protein kinase 12)

Total number of chains: 10
Active chains: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 50.0% AF-P53778-K1A
DFGin ABAminus 3 30.0% 7CGAB
DFGin BLBplus 2 20.0% 6UNAA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
MK12_HUMAN 1CM8A 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 8 - 353 0 TPO183,PTR185 None Mitogen-activated protein kinase 12 Homo sapiens
MK12_HUMAN 1CM8B 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 8 - 353 0 TPO183,PTR185 None Mitogen-activated protein kinase 12 Homo sapiens
MK12_HUMAN AF-P53778-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 19 - 319 0 None None Mitogen-activated protein kinase 12 Homo sapiens
MK12_HUMAN AF-P53778-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 19 - 319 0 None None Mitogen-activated protein kinase 12 Homo sapiens
MK12_HUMAN 7CGAB 3.15 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiio No_ligand No_ligand 9 - 353 0 None None Mitogen-activated protein kinase 12 Homo sapiens
MK12_HUMAN 7CGAC 3.15 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiio No_ligand No_ligand 9 - 353 0 None None Mitogen-activated protein kinase 12 Homo sapiens
MK12_HUMAN 7CGAD 3.15 Inactive DFGin‑ABAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiio No_ligand No_ligand 9 - 353 0 None None Mitogen-activated protein kinase 12 Homo sapiens
MK12_HUMAN 7CGAA 3.15 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiio No_ligand No_ligand 9 - 353 0 None None Mitogen-activated protein kinase 12 Homo sapiens
MK12_HUMAN 6UNAA 2.554 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaooi APEdist_nnno No_ligand No_ligand 10 - 351 0 None Q31R Mitogen-activated protein kinase 12 Homo sapiens
MK12_HUMAN 6UNAB 2.554 Inactive DFGin‑BLBplus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno No_ligand No_ligand 9 - 351 0 None Q31R Mitogen-activated protein kinase 12 Homo sapiens

CMGC_MAPK12 (Mitogen-activated protein kinase 12)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism