MAPK12 (Mitogen-activated protein kinase 12)

Group: CMGC

Uniprot: MK12_HUMAN

Domain boundary: 27 - 311

Total number of chains: 9

Spatial	Dihedral	Chains	Representative
DFGin	BLAminus	4	AF-P53778-K1A
DFGin	ABAminus	3	7CGAB
DFGin	BLBplus	2	6UNAA

Database table as tsv

PDB	Resolution	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type	Residues in structure	Mutation	Phosphorylation	Unresolved residues in A-loop
7CGAB	3.15	Inactive	DFGin	ABAminus	in-in	in-out	No_ligand	No_ligand	9 - 353	None	None	0
7CGAC	3.15	Inactive	DFGin	ABAminus	in-in	in-out	No_ligand	No_ligand	9 - 353	None	None	0
7CGAD	3.15	Inactive	DFGin	ABAminus	in-in	in-out	No_ligand	No_ligand	9 - 353	None	None	0
AF-P53778-K1A	-1.0	Active	DFGin	BLAminus	in-in	in-in	No_ligand	No_ligand	19 - 319	None	None	0
7CGAA	3.15	Inactive	DFGin	BLAminus	in-in	in-out	No_ligand	No_ligand	9 - 353	None	None	0
1CM8A	2.4	Active	DFGin	BLAminus	in-in	in-in	ANP	Type1	8 - 353	None	X183,X185	0
1CM8B	2.4	Active	DFGin	BLAminus	in-in	in-in	ANP	Type1	8 - 353	None	X183,X185	0
6UNAA	2.554	Inactive	DFGin	BLBplus	in-in	none-out	No_ligand	No_ligand	10 - 351	Q31R	None	11
6UNAB	2.554	Inactive	DFGin	BLBplus	in-in	none-out	No_ligand	No_ligand	9 - 351	Q31R	None	12

MAPK12 (Mitogen-activated protein kinase 12)

Group: CMGC

Total number of chains: 9

Spatial	Dihedral	Chains	Representative
DFGin	BLAminus	4	AF-P53778-K1A
DFGin	ABAminus	3	7CGAB
DFGin	BLBplus	2	6UNAA

Database table as tsv

Organism	UniprotID	PDB	Resolution	Activity Label	Spatial Label	Dihedral Label	Chelix-SaltBridge	ActLoopNT-ActLoopCT	Ligand	Type	Residues in structure	Mutation	Phosphorylation	Unresolved residues in A-loop
Homo sapiens	MK12_HUMAN	7CGAB	3.15	Inactive	DFGin	ABAminus	in-in	in-out	No_ligand	No_ligand	9 - 353	None	None	0
Homo sapiens	MK12_HUMAN	7CGAC	3.15	Inactive	DFGin	ABAminus	in-in	in-out	No_ligand	No_ligand	9 - 353	None	None	0
Homo sapiens	MK12_HUMAN	7CGAD	3.15	Inactive	DFGin	ABAminus	in-in	in-out	No_ligand	No_ligand	9 - 353	None	None	0
Homo sapiens	MK12_HUMAN	AF-P53778-K1A	-1.0	Active	DFGin	BLAminus	in-in	in-in	No_ligand	No_ligand	19 - 319	None	None	0
Homo sapiens	MK12_HUMAN	7CGAA	3.15	Inactive	DFGin	BLAminus	in-in	in-out	No_ligand	No_ligand	9 - 353	None	None	0
Homo sapiens	MK12_HUMAN	1CM8A	2.4	Active	DFGin	BLAminus	in-in	in-in	ANP	Type1	8 - 353	None	X183,X185	0
Homo sapiens	MK12_HUMAN	1CM8B	2.4	Active	DFGin	BLAminus	in-in	in-in	ANP	Type1	8 - 353	None	X183,X185	0
Homo sapiens	MK12_HUMAN	6UNAA	2.554	Inactive	DFGin	BLBplus	in-in	none-out	No_ligand	No_ligand	10 - 351	Q31R	None	11
Homo sapiens	MK12_HUMAN	6UNAB	2.554	Inactive	DFGin	BLBplus	in-in	none-out	No_ligand	No_ligand	9 - 351	Q31R	None	12

MAPK12 (Mitogen-activated protein kinase 12)

No non-human structures known.