DAPK1 (Death-associated protein kinase 1)

Group: CAMK
Uniprot: DAPK1_HUMAN
Domain boundary: 13 - 275


Total number of chains: 80
Spatial Dihedral Chains Representative
DFGin BLAminus 74 AF-P53355-K1A
DFGin ABAminus 3 1WVYA
DFGin BLBminus 1 3ZXTA
None None 2 2Y4PD
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
1WVYA 2.8 Inactive DFGin ABAminus in-in in-in STU Type1 4 - 276 None None 0
9INVA 1.61 Inactive DFGin ABAminus in-in in-in HCC Type1 2 - 277 None None 0
9INWA 1.52 Inactive DFGin ABAminus in-in in-in A1L2V Type1 2 - 277 None None 0
1WVWA 2.4 Active DFGin BLAminus in-in in-in No_ligand No_ligand 2 - 276 None None 0
4PF4A 1.13 Active DFGin BLAminus in-in in-in No_ligand No_ligand 1 - 277 None None 0
AF-P53355-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 5 - 283 None None 0
2Y4PA 2.65 None DFGin BLAminus in-in in-none No_ligand No_ligand 4 - 275 None None 10
2Y4PC 2.65 None DFGin BLAminus in-in in-none No_ligand No_ligand 2 - 276 None None 10
5AV1A 1.5 Active DFGin BLAminus in-in in-in No_ligand No_ligand 2 - 277 None None 0
6IN4A 1.8 Active DFGin BLAminus in-in in-in No_ligand No_ligand 2 - 277 None None 0
1JKSA 1.5 Active DFGin BLAminus in-in in-in No_ligand No_ligand 2 - 294 None None 0
1JKTA 3.5 Inactive DFGin BLAminus in-out out-out No_ligand No_ligand 2 - 277 None None 0
1JKTB 3.5 Inactive DFGin BLAminus out-out in-out No_ligand No_ligand 2 - 277 None None 0
3DGKA 1.7 Active DFGin BLAminus in-in in-in No_ligand No_ligand 2 - 277 Q23K None 0
2XZSA 2.0 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 4 - 312 None None 0
2XZSB 2.0 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 4 - 302 None None 0
6QMOA 1.87 Active DFGin BLAminus in-in in-in No_ligand No_ligand 4 - 302 S289E,S308A None 0
6QN4A 2.5 Active DFGin BLAminus in-in in-in No_ligand No_ligand 2 - 277 S289E,S308E None 0
4UV0A 2.49 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 3 - 302 S289C None 0
2Y0AA 2.6 Active DFGin BLAminus in-in in-in No_ligand No_ligand 3 - 302 None None 0
2X0GA 2.2 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 3 - 320 None None 0
4TL0A 2.7 Active DFGin BLAminus out-in in-in No_ligand No_ligand 2 - 301 S289E None 0
4B4LA 1.75 Active DFGin BLAminus in-in in-in No_ligand No_ligand 5 - 303 R302A None 0
6FHAA 2.3 Active DFGin BLAminus in-in in-in No_ligand No_ligand 4 - 302 S289A,S308A None 0
6FHBA 1.75 Active DFGin BLAminus in-in in-in No_ligand No_ligand 2 - 302 S289A,S308E None 0
2W4JA 1.3 Active DFGin BLAminus in-in in-in ADP Type1 2 - 277 None None 0
1WVXA 2.6 Inactive DFGin BLAminus in-in in-out BD4 Type1 2 - 276 None None 0
2YAKA 2.2 Inactive DFGin BLAminus out-out in-in OSV Type1 2 - 278 None None 0
3ZXTB 2.65 None DFGin BLAminus in-in in-none ACP Type1 7 - 276 None None 10
3ZXTC 2.65 None DFGin BLAminus in-in in-none ACP Type1 5 - 276 None None 11
3ZXTD 2.65 None DFGin BLAminus in-in in-none ACP Type1 7 - 276 None None 10
5AUTA 1.7 Active DFGin BLAminus in-in in-in 2AN Type1 2 - 277 None None 0
5AUVA 1.5 Active DFGin BLAminus in-in in-in AGI Type1 2 - 277 None None 0
5AUXA 1.5 Active DFGin BLAminus in-in in-in KMP Type1 2 - 277 None None 0
5AUZA 1.6 Active DFGin BLAminus in-in in-in GEN Type1 2 - 277 None None 0
5AV0A 1.85 Active DFGin BLAminus in-in in-in 47X Type1 2 - 277 None None 0
5AV2A 1.502 Active DFGin BLAminus in-in in-in KMP Type1 2 - 277 None None 0
5AV3A 1.9 Active DFGin BLAminus in-in in-in KMP Type1 2 - 277 None None 0
5AV4A 1.4 Active DFGin BLAminus in-in in-in GEN Type1 2 - 277 None None 0
6AARA 1.95 Active DFGin BLAminus in-in in-in 9TF Type1 2 - 277 None None 0
7CCWA 1.4 Active DFGin BLAminus in-in in-in STL Type1 2 - 277 None None 0
8IE6A 1.701 Active DFGin BLAminus in-in in-in 8KZ Type1 2 - 277 None None 0
8IE7A 1.849 Active DFGin BLAminus in-in in-in 3RL Type1 2 - 277 None None 0
8IE8A 1.75 Active DFGin BLAminus in-in in-in P5O Type1 2 - 277 None None 0
9INXA 1.72 Active DFGin BLAminus in-in in-in A1L2W Type1 2 - 277 None None 0
1P4FA 1.9 Active DFGin BLAminus in-in in-in 86Q Type1 2 - 293 None None 0
9N1TA 1.43 Active DFGin BLAminus in-in in-in A1BU8 Type1 2 - 277 None None 0
9N2MA 1.35 Active DFGin BLAminus in-in in-in A1BVM Type1 2 - 277 None None 0
9N2OA 1.49 Active DFGin BLAminus in-in in-in A1BVL Type1 2 - 277 None None 0
1IG1A 1.8 Active DFGin BLAminus in-in in-in ANP Type1 2 - 294 None None 0
1JKKA 2.4 Active DFGin BLAminus in-in in-in ANP Type1 2 - 293 None None 0
1JKLA 1.62 Active DFGin BLAminus in-in in-in ANP Type1 2 - 294 None None 0
3EH9A 1.7 Active DFGin BLAminus in-in in-in ADP Type1 2 - 277 None None 0
3EHAA 1.6 Active DFGin BLAminus in-in in-in ANP Type1 2 - 277 None None 0
3F5GA 1.85 Active DFGin BLAminus in-in in-in ADP Type1 2 - 277 None None 0
4YO4A 1.6 Active DFGin BLAminus in-in in-in 4FT Type1 2 - 277 None None 0
4YPDA 1.4 Active DFGin BLAminus in-in in-in DKG Type1 2 - 277 None None 0
9DUBA 1.5 Active DFGin BLAminus in-in in-in A1BB7 Type1 2 - 277 None None 0
3F5UA 2.0 Active DFGin BLAminus in-in in-in ANP Type1 2 - 277 None None 0
2W4KA 1.9 Active DFGin BLAminus in-in in-in ADP Type1 2 - 302 None None 0
3DFCB 1.9 Active DFGin BLAminus in-in in-in ANP Type1 2 - 277 Q23K None 0
4TXCA 1.951 Active DFGin BLAminus in-in in-in 38G Type1 2 - 277 None None 0
9MIUA 1.9 Active DFGin BLAminus in-in in-in A1BLJ Type1 2 - 277 None None 0
3GU4A 1.35 Active DFGin BLAminus in-in in-in ANP Type1 2 - 277 Q23V None 0
3GU5A 1.65 Active DFGin BLAminus in-in in-in ANP Type1 2 - 277 Q23V None 0
3GU6A 1.49 Active DFGin BLAminus in-in in-in ADP Type1 2 - 277 Q23V None 0
3GU7A 1.9 Active DFGin BLAminus in-in in-in ADP Type1 2 - 277 Q23V None 0
2XUUA 1.8 Active DFGin BLAminus in-in in-in ADP Type1 2 - 302 E182A None 0
3GU8A 1.6 Active DFGin BLAminus in-in in-in 3GU Type1 2 - 277 L93G None 0
3GUBA 1.71 Active DFGin BLAminus in-in in-in GUB Type1 2 - 277 L93G None 0
9DUEA 1.65 Inactive DFGin BLAminus in-out in-in A1BB6 BO3 Type1 Allosteric 2 - 277 None None 0
5AUUA 1.7 Inactive DFGin BLAminus in-out in-in LU2 Type1.5_Back 2 - 277 None None 0
5AUWA 1.5 Inactive DFGin BLAminus in-out in-in QUE Type1.5_Back 2 - 277 None None 0
5AUYA 2.0 Inactive DFGin BLAminus in-out in-in MRI Type1.5_Back 2 - 277 None None 0
7CCUA 1.649 Inactive DFGin BLAminus in-out in-in STL Type1.5_Back 2 - 277 None None 0
7CCVA 1.753 Inactive DFGin BLAminus in-out in-in PIT Type1.5_Back 2 - 277 None None 0
8IE5A 1.803 Active DFGin BLAminus in-in in-in EZE Type1.5_Back 2 - 277 None None 0
3ZXTA 2.65 Inactive DFGin BLBminus in-in in-none ACP Type1 7 - 276 None None 12
2Y4PB 2.65 Inactive None None none-none in-none No_ligand No_ligand 57 - 275 None None 11
2Y4PD 2.65 Inactive None None none-none in-none No_ligand No_ligand 56 - 276 None None 11

DAPK1 (Death-associated protein kinase 1)

Group: CAMK
Total number of chains: 80
Spatial Dihedral Chains Representative
DFGin BLAminus 74 AF-P53355-K1A
DFGin ABAminus 3 1WVYA
DFGin BLBminus 1 3ZXTA
None None 2 2Y4PD
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens DAPK1_HUMAN 1WVYA 2.8 Inactive DFGin ABAminus in-in in-in STU Type1 4 - 276 None None 0
Homo sapiens DAPK1_HUMAN 9INVA 1.61 Inactive DFGin ABAminus in-in in-in HCC Type1 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 9INWA 1.52 Inactive DFGin ABAminus in-in in-in A1L2V Type1 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 1WVWA 2.4 Active DFGin BLAminus in-in in-in No_ligand No_ligand 2 - 276 None None 0
Homo sapiens DAPK1_HUMAN 4PF4A 1.13 Active DFGin BLAminus in-in in-in No_ligand No_ligand 1 - 277 None None 0
Homo sapiens DAPK1_HUMAN AF-P53355-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 5 - 283 None None 0
Homo sapiens DAPK1_HUMAN 2Y4PA 2.65 None DFGin BLAminus in-in in-none No_ligand No_ligand 4 - 275 None None 10
Homo sapiens DAPK1_HUMAN 2Y4PC 2.65 None DFGin BLAminus in-in in-none No_ligand No_ligand 2 - 276 None None 10
Homo sapiens DAPK1_HUMAN 5AV1A 1.5 Active DFGin BLAminus in-in in-in No_ligand No_ligand 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 6IN4A 1.8 Active DFGin BLAminus in-in in-in No_ligand No_ligand 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 1JKSA 1.5 Active DFGin BLAminus in-in in-in No_ligand No_ligand 2 - 294 None None 0
Homo sapiens DAPK1_HUMAN 1JKTA 3.5 Inactive DFGin BLAminus in-out out-out No_ligand No_ligand 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 1JKTB 3.5 Inactive DFGin BLAminus out-out in-out No_ligand No_ligand 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 3DGKA 1.7 Active DFGin BLAminus in-in in-in No_ligand No_ligand 2 - 277 Q23K None 0
Homo sapiens DAPK1_HUMAN 2XZSA 2.0 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 4 - 312 None None 0
Homo sapiens DAPK1_HUMAN 2XZSB 2.0 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 4 - 302 None None 0
Homo sapiens DAPK1_HUMAN 6QMOA 1.87 Active DFGin BLAminus in-in in-in No_ligand No_ligand 4 - 302 S289E,S308A None 0
Homo sapiens DAPK1_HUMAN 6QN4A 2.5 Active DFGin BLAminus in-in in-in No_ligand No_ligand 2 - 277 S289E,S308E None 0
Homo sapiens DAPK1_HUMAN 4UV0A 2.49 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 3 - 302 S289C None 0
Homo sapiens DAPK1_HUMAN 2Y0AA 2.6 Active DFGin BLAminus in-in in-in No_ligand No_ligand 3 - 302 None None 0
Homo sapiens DAPK1_HUMAN 2X0GA 2.2 Inactive DFGin BLAminus out-out in-in No_ligand No_ligand 3 - 320 None None 0
Homo sapiens DAPK1_HUMAN 4TL0A 2.7 Active DFGin BLAminus out-in in-in No_ligand No_ligand 2 - 301 S289E None 0
Homo sapiens DAPK1_HUMAN 4B4LA 1.75 Active DFGin BLAminus in-in in-in No_ligand No_ligand 5 - 303 R302A None 0
Homo sapiens DAPK1_HUMAN 6FHAA 2.3 Active DFGin BLAminus in-in in-in No_ligand No_ligand 4 - 302 S289A,S308A None 0
Homo sapiens DAPK1_HUMAN 6FHBA 1.75 Active DFGin BLAminus in-in in-in No_ligand No_ligand 2 - 302 S289A,S308E None 0
Homo sapiens DAPK1_HUMAN 2W4JA 1.3 Active DFGin BLAminus in-in in-in ADP Type1 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 1WVXA 2.6 Inactive DFGin BLAminus in-in in-out BD4 Type1 2 - 276 None None 0
Homo sapiens DAPK1_HUMAN 2YAKA 2.2 Inactive DFGin BLAminus out-out in-in OSV Type1 2 - 278 None None 0
Homo sapiens DAPK1_HUMAN 3ZXTB 2.65 None DFGin BLAminus in-in in-none ACP Type1 7 - 276 None None 10
Homo sapiens DAPK1_HUMAN 3ZXTC 2.65 None DFGin BLAminus in-in in-none ACP Type1 5 - 276 None None 11
Homo sapiens DAPK1_HUMAN 3ZXTD 2.65 None DFGin BLAminus in-in in-none ACP Type1 7 - 276 None None 10
Homo sapiens DAPK1_HUMAN 5AUTA 1.7 Active DFGin BLAminus in-in in-in 2AN Type1 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 5AUVA 1.5 Active DFGin BLAminus in-in in-in AGI Type1 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 5AUXA 1.5 Active DFGin BLAminus in-in in-in KMP Type1 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 5AUZA 1.6 Active DFGin BLAminus in-in in-in GEN Type1 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 5AV0A 1.85 Active DFGin BLAminus in-in in-in 47X Type1 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 5AV2A 1.502 Active DFGin BLAminus in-in in-in KMP Type1 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 5AV3A 1.9 Active DFGin BLAminus in-in in-in KMP Type1 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 5AV4A 1.4 Active DFGin BLAminus in-in in-in GEN Type1 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 6AARA 1.95 Active DFGin BLAminus in-in in-in 9TF Type1 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 7CCWA 1.4 Active DFGin BLAminus in-in in-in STL Type1 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 8IE6A 1.701 Active DFGin BLAminus in-in in-in 8KZ Type1 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 8IE7A 1.849 Active DFGin BLAminus in-in in-in 3RL Type1 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 8IE8A 1.75 Active DFGin BLAminus in-in in-in P5O Type1 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 9INXA 1.72 Active DFGin BLAminus in-in in-in A1L2W Type1 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 1P4FA 1.9 Active DFGin BLAminus in-in in-in 86Q Type1 2 - 293 None None 0
Homo sapiens DAPK1_HUMAN 9N1TA 1.43 Active DFGin BLAminus in-in in-in A1BU8 Type1 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 9N2MA 1.35 Active DFGin BLAminus in-in in-in A1BVM Type1 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 9N2OA 1.49 Active DFGin BLAminus in-in in-in A1BVL Type1 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 1IG1A 1.8 Active DFGin BLAminus in-in in-in ANP Type1 2 - 294 None None 0
Homo sapiens DAPK1_HUMAN 1JKKA 2.4 Active DFGin BLAminus in-in in-in ANP Type1 2 - 293 None None 0
Homo sapiens DAPK1_HUMAN 1JKLA 1.62 Active DFGin BLAminus in-in in-in ANP Type1 2 - 294 None None 0
Homo sapiens DAPK1_HUMAN 3EH9A 1.7 Active DFGin BLAminus in-in in-in ADP Type1 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 3EHAA 1.6 Active DFGin BLAminus in-in in-in ANP Type1 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 3F5GA 1.85 Active DFGin BLAminus in-in in-in ADP Type1 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 4YO4A 1.6 Active DFGin BLAminus in-in in-in 4FT Type1 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 4YPDA 1.4 Active DFGin BLAminus in-in in-in DKG Type1 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 9DUBA 1.5 Active DFGin BLAminus in-in in-in A1BB7 Type1 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 3F5UA 2.0 Active DFGin BLAminus in-in in-in ANP Type1 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 2W4KA 1.9 Active DFGin BLAminus in-in in-in ADP Type1 2 - 302 None None 0
Homo sapiens DAPK1_HUMAN 3DFCB 1.9 Active DFGin BLAminus in-in in-in ANP Type1 2 - 277 Q23K None 0
Homo sapiens DAPK1_HUMAN 4TXCA 1.951 Active DFGin BLAminus in-in in-in 38G Type1 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 9MIUA 1.9 Active DFGin BLAminus in-in in-in A1BLJ Type1 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 3GU4A 1.35 Active DFGin BLAminus in-in in-in ANP Type1 2 - 277 Q23V None 0
Homo sapiens DAPK1_HUMAN 3GU5A 1.65 Active DFGin BLAminus in-in in-in ANP Type1 2 - 277 Q23V None 0
Homo sapiens DAPK1_HUMAN 3GU6A 1.49 Active DFGin BLAminus in-in in-in ADP Type1 2 - 277 Q23V None 0
Homo sapiens DAPK1_HUMAN 3GU7A 1.9 Active DFGin BLAminus in-in in-in ADP Type1 2 - 277 Q23V None 0
Homo sapiens DAPK1_HUMAN 2XUUA 1.8 Active DFGin BLAminus in-in in-in ADP Type1 2 - 302 E182A None 0
Homo sapiens DAPK1_HUMAN 3GU8A 1.6 Active DFGin BLAminus in-in in-in 3GU Type1 2 - 277 L93G None 0
Homo sapiens DAPK1_HUMAN 3GUBA 1.71 Active DFGin BLAminus in-in in-in GUB Type1 2 - 277 L93G None 0
Homo sapiens DAPK1_HUMAN 9DUEA 1.65 Inactive DFGin BLAminus in-out in-in A1BB6 BO3 Type1 Allosteric 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 5AUUA 1.7 Inactive DFGin BLAminus in-out in-in LU2 Type1.5_Back 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 5AUWA 1.5 Inactive DFGin BLAminus in-out in-in QUE Type1.5_Back 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 5AUYA 2.0 Inactive DFGin BLAminus in-out in-in MRI Type1.5_Back 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 7CCUA 1.649 Inactive DFGin BLAminus in-out in-in STL Type1.5_Back 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 7CCVA 1.753 Inactive DFGin BLAminus in-out in-in PIT Type1.5_Back 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 8IE5A 1.803 Active DFGin BLAminus in-in in-in EZE Type1.5_Back 2 - 277 None None 0
Homo sapiens DAPK1_HUMAN 3ZXTA 2.65 Inactive DFGin BLBminus in-in in-none ACP Type1 7 - 276 None None 12
Homo sapiens DAPK1_HUMAN 2Y4PB 2.65 Inactive None None none-none in-none No_ligand No_ligand 57 - 275 None None 11
Homo sapiens DAPK1_HUMAN 2Y4PD 2.65 Inactive None None none-none in-none No_ligand No_ligand 56 - 276 None None 11

DAPK1 (Death-associated protein kinase 1)

No non-human structures known.