TYR_LCK (Tyrosine-protein kinase Lck)

Total number of chains: 39
Active chains: 27
Uniprot: LCK_HUMAN
Kinase Domain Residues: 245 - 496
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 28 71.8% AF-P06239-K1A
DFGout BBAminus 6 15.4% 6PDJA
DFGin BLBplus 2 5.1% 4C3FA
DFGout None 2 5.1% 2OFVA
DFGin BLBminus 1 2.6% 3B2WA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
1QPCA 1.6 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 231 - 502 0 PTR394 None Tyrosine-protein kinase Lck
AF-P06239-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 237 - 504 0 None None Tyrosine-protein kinase Lck
AF-P06239-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 237 - 504 0 None None Tyrosine-protein kinase Lck
3LCKA 1.7 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 231 - 501 0 PTR394 None Tyrosine-protein kinase Lck
2OF2A 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 547 Type1 231 - 501 0 None None Tyrosine-protein kinase Lck
2OF4A 2.7 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 979 Type1 231 - 501 0 None None Tyrosine-protein kinase Lck
3BYOA 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai AM9 Type1 231 - 501 0 PTR394 None Tyrosine-protein kinase Lck
2OFUA 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 1N9 Type1 229 - 501 0 PTR394 None Tyrosine-protein kinase Lck
1QPEA 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai PP2 Type1 231 - 501 0 PTR394 None Tyrosine-protein kinase Lck
1QPJA 2.2 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai STU Type1 236 - 501 0 PTR394 None Tyrosine-protein kinase Lck
2ZM1A 2.1 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KSF Type1 231 - 501 0 PTR394 None Tyrosine-protein kinase Lck
2ZM4A 2.7 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KSM Type1 231 - 501 0 PTR394 None Tyrosine-protein kinase Lck
2ZYBA 2.55 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KSL Type1 231 - 501 0 PTR394 None Tyrosine-protein kinase Lck
3AC1A 1.99 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KZI Type1 231 - 502 0 PTR394 None Tyrosine-protein kinase Lck
3AC2A 2.1 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KSE Type1 231 - 502 0 PTR394 None Tyrosine-protein kinase Lck
3AC3A 2.55 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KSH Type1 231 - 502 0 PTR394 None Tyrosine-protein kinase Lck
3AC4A 2.7 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KZL Type1 231 - 502 0 PTR394 None Tyrosine-protein kinase Lck
3AC5A 2.5 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KZM Type1 231 - 502 0 PTR394 None Tyrosine-protein kinase Lck
3ACJA 2.2 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KSS Type1 231 - 502 0 PTR394 None Tyrosine-protein kinase Lck
3ACKA 2.6 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KSR Type1 231 - 502 0 PTR394 None Tyrosine-protein kinase Lck
3AD4A 2.2 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KBM Type1 231 - 502 0 PTR394 None Tyrosine-protein kinase Lck
3AD5A 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 5PB Type1 230 - 502 0 PTR394 None Tyrosine-protein kinase Lck
3AD6A 2.15 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KSC Type1 230 - 502 0 PTR394 None Tyrosine-protein kinase Lck
3KXZA 2.37 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 925 Type1 238 - 501 0 PTR394 None Tyrosine-protein kinase Lck
1QPDA 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai STU Type1 231 - 502 0 PTR394 None Tyrosine-protein kinase Lck
3BYMA 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai AM0 Type1.5_Back 230 - 501 0 PTR394 None Tyrosine-protein kinase Lck
3KMMA 2.8 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai LHL Type1.5_Back 231 - 501 0 PTR394 Y505F Tyrosine-protein kinase Lck
3AC8A 2.3 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai KSK Type1 231 - 501 0 PTR394 None Tyrosine-protein kinase Lck
3B2WA 2.3 Inactive DFGin‑BLBminus in-in out-out TYR APEdihe_oiiai APEdist_aaai 9NH Type1 238 - 500 0 None None Tyrosine-protein kinase Lck
3MPMA 1.95 Inactive DFGin‑BLBplus in-in out-out TYR APEdihe_nnoai APEdist_aaao 5LK Type1 238 - 498 0 None D364N Tyrosine-protein kinase Lck
4C3FA 1.72 Inactive DFGin‑BLBplus in-in out-out TYR APEdihe_nniai APEdist_aaao 7KW Type1 238 - 498 0 None D364N Tyrosine-protein kinase Lck
6PDJA 1.81 Inactive DFGout‑BBAminus out-none in-in TYR APEdihe_iiiai APEdist_aaai ODJ Type1.5_Front 225 - 500 0 PTR394 None Tyrosine-protein kinase Lck
2OG8A 2.3 Inactive DFGout‑BBAminus in-in none-none TYR APEdihe_nnnai APEdist_aaan 1N8 Type2 237 - 499 0 None None Tyrosine-protein kinase Lck
2OG8B 2.3 Inactive DFGout‑BBAminus in-in none-none TYR APEdihe_nnnai APEdist_aaan 1N8 Type2 237 - 499 0 None None Tyrosine-protein kinase Lck
3BYSA 2.2 Inactive DFGout‑BBAminus in-in none-out TYR APEdihe_nnnao APEdist_aaan AM5 Type2 230 - 501 0 None None Tyrosine-protein kinase Lck
3BYUA 2.3 Inactive DFGout‑BBAminus in-in none-out TYR APEdihe_nioao APEdist_aaai AM6 Type2 231 - 501 0 None None Tyrosine-protein kinase Lck
2PL0A 2.8 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai STI Type2 231 - 498 0 None None Tyrosine-protein kinase Lck
2OFVA 2.0 Inactive DFGout‑None in-in none-none TYR APEdihe_nnnan APEdist_aaan 242 Type2 232 - 498 0 None None Tyrosine-protein kinase Lck
2OFVB 2.0 Inactive DFGout‑None in-in out-none TYR APEdihe_nnnai APEdist_aaan 242 Type2 232 - 498 0 None None Tyrosine-protein kinase Lck

TYR_LCK (Tyrosine-protein kinase Lck)

Total number of chains: 39
Active chains: 27
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 28 71.8% AF-P06239-K1A
DFGout BBAminus 6 15.4% 6PDJA
DFGin BLBplus 2 5.1% 4C3FA
DFGout None 2 5.1% 2OFVA
DFGin BLBminus 1 2.6% 3B2WA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
LCK_HUMAN 1QPCA 1.6 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ANP ATPlike 231 - 502 0 PTR394 None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN AF-P06239-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 237 - 504 0 None None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN AF-P06239-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 237 - 504 0 None None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 3LCKA 1.7 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 231 - 501 0 PTR394 None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 2OF2A 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 547 Type1 231 - 501 0 None None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 2OF4A 2.7 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 979 Type1 231 - 501 0 None None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 3BYOA 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai AM9 Type1 231 - 501 0 PTR394 None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 2OFUA 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 1N9 Type1 229 - 501 0 PTR394 None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 1QPEA 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai PP2 Type1 231 - 501 0 PTR394 None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 1QPJA 2.2 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai STU Type1 236 - 501 0 PTR394 None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 2ZM1A 2.1 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KSF Type1 231 - 501 0 PTR394 None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 2ZM4A 2.7 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KSM Type1 231 - 501 0 PTR394 None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 2ZYBA 2.55 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KSL Type1 231 - 501 0 PTR394 None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 3AC1A 1.99 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KZI Type1 231 - 502 0 PTR394 None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 3AC2A 2.1 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KSE Type1 231 - 502 0 PTR394 None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 3AC3A 2.55 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KSH Type1 231 - 502 0 PTR394 None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 3AC4A 2.7 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KZL Type1 231 - 502 0 PTR394 None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 3AC5A 2.5 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KZM Type1 231 - 502 0 PTR394 None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 3ACJA 2.2 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KSS Type1 231 - 502 0 PTR394 None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 3ACKA 2.6 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KSR Type1 231 - 502 0 PTR394 None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 3AD4A 2.2 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KBM Type1 231 - 502 0 PTR394 None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 3AD5A 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 5PB Type1 230 - 502 0 PTR394 None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 3AD6A 2.15 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KSC Type1 230 - 502 0 PTR394 None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 3KXZA 2.37 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 925 Type1 238 - 501 0 PTR394 None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 1QPDA 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai STU Type1 231 - 502 0 PTR394 None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 3BYMA 2.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai AM0 Type1.5_Back 230 - 501 0 PTR394 None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 3KMMA 2.8 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai LHL Type1.5_Back 231 - 501 0 PTR394 Y505F Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 3AC8A 2.3 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai KSK Type1 231 - 501 0 PTR394 None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 3B2WA 2.3 Inactive DFGin‑BLBminus in-in out-out TYR APEdihe_oiiai APEdist_aaai 9NH Type1 238 - 500 0 None None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 3MPMA 1.95 Inactive DFGin‑BLBplus in-in out-out TYR APEdihe_nnoai APEdist_aaao 5LK Type1 238 - 498 0 None D364N Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 4C3FA 1.72 Inactive DFGin‑BLBplus in-in out-out TYR APEdihe_nniai APEdist_aaao 7KW Type1 238 - 498 0 None D364N Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 6PDJA 1.81 Inactive DFGout‑BBAminus out-none in-in TYR APEdihe_iiiai APEdist_aaai ODJ Type1.5_Front 225 - 500 0 PTR394 None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 2OG8A 2.3 Inactive DFGout‑BBAminus in-in none-none TYR APEdihe_nnnai APEdist_aaan 1N8 Type2 237 - 499 0 None None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 2OG8B 2.3 Inactive DFGout‑BBAminus in-in none-none TYR APEdihe_nnnai APEdist_aaan 1N8 Type2 237 - 499 0 None None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 3BYSA 2.2 Inactive DFGout‑BBAminus in-in none-out TYR APEdihe_nnnao APEdist_aaan AM5 Type2 230 - 501 0 None None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 3BYUA 2.3 Inactive DFGout‑BBAminus in-in none-out TYR APEdihe_nioao APEdist_aaai AM6 Type2 231 - 501 0 None None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 2PL0A 2.8 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai STI Type2 231 - 498 0 None None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 2OFVA 2.0 Inactive DFGout‑None in-in none-none TYR APEdihe_nnnan APEdist_aaan 242 Type2 232 - 498 0 None None Tyrosine-protein kinase Lck Homo sapiens
LCK_HUMAN 2OFVB 2.0 Inactive DFGout‑None in-in out-none TYR APEdihe_nnnai APEdist_aaan 242 Type2 232 - 498 0 None None Tyrosine-protein kinase Lck Homo sapiens

TYR_LCK (Tyrosine-protein kinase Lck)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism