Ligand: 38Z

Total number of chains: 5
Active chains: 1
Total number of genes: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 80.0% 4QTBA
DFGin ABAminus 1 20.0% 4QTDA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
CMGC MAPK1 MK01_HUMAN 4QTAA 1.45 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn 38Z Type1.5_Front 10 - 358 0 None None Mitogen-activated protein kinase 1
CMGC MAPK3 MK03_HUMAN 4QTBA 1.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii 38Z Type1.5_Front 24 - 374 0 None None Mitogen-activated protein kinase 3
CMGC MAPK3 MK03_HUMAN 4QTBB 1.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii 38Z Type1.5_Front 27 - 374 0 None None Mitogen-activated protein kinase 3
CMGC MAPK8 MK08_HUMAN 4QTDA 1.5 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaiii APEdist_oooo 38Z, ANP Type1, Allosteric 6 - 363 0 None None Mitogen-activated protein kinase 8
OTHER HASPIN HASP_HUMAN 4QTCA 1.4 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 38Z Type1 469 - 798 0 None None Serine/threonine-protein kinase haspin

Ligand: 38Z

Total number of chains: 7
Active chains: 1
Total number of genes: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 6 85.7% 4QTBA
DFGin ABAminus 1 14.3% 4QTDA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC MAPK1 MK01_HUMAN 4QTAA 1.45 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aanoi APEdist_nnnn 38Z Type1.5_Front 10 - 358 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK3 MK03_HUMAN 4QTBA 1.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii 38Z Type1.5_Front 24 - 374 0 None None Mitogen-activated protein kinase 3 Homo sapiens
CMGC MAPK3 MK03_HUMAN 4QTBB 1.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii 38Z Type1.5_Front 27 - 374 0 None None Mitogen-activated protein kinase 3 Homo sapiens
CMGC MAPK8 MK08_HUMAN 4QTDA 1.5 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaiii APEdist_oooo 38Z, ANP Type1, Allosteric 6 - 363 0 None None Mitogen-activated protein kinase 8 Homo sapiens
OTHER HASPIN HASP_HUMAN 4QTCA 1.4 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa 38Z Type1 469 - 798 0 None None Serine/threonine-protein kinase haspin Homo sapiens
CMGC MAPK1 MK01_RAT 5HD7A 1.69 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii 38Z Type1 9 - 355 0 None G167D Mitogen-activated protein kinase 1 Rattus norvegicus
CMGC MAPK1 MK01_RAT 5HD4A 1.45 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii 38Z Type1.5_Front 9 - 355 0 None None Mitogen-activated protein kinase 1 Rattus norvegicus

Ligand: 38Z

Total number of chains: 2
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 5HD4A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC MAPK1 MK01_RAT 5HD7A 1.69 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii 38Z Type1 9 - 355 0 None G167D Mitogen-activated protein kinase 1 Rattus norvegicus
CMGC MAPK1 MK01_RAT 5HD4A 1.45 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_oiii 38Z Type1.5_Front 9 - 355 0 None None Mitogen-activated protein kinase 1 Rattus norvegicus