AGC_PRKG1 (cGMP-dependent protein kinase 1)

Total number of chains: 19
Active chains: 9
Uniprot: KGP1_HUMAN
Kinase Domain Residues: 360 - 619
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 13 68.4% AF-Q13976-K1A
DFGin ABAminus 6 31.6% 7T4UA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
6BG2A 1.83 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 336 - 671 0 TPO517 None cGMP-dependent protein kinase 1
6BG2B 1.83 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 346 - 671 0 TPO517 None cGMP-dependent protein kinase 1
6BG2C 1.83 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 337 - 671 0 TPO517 None cGMP-dependent protein kinase 1
6BG2D 1.83 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 344 - 671 0 TPO517 None cGMP-dependent protein kinase 1
7LV3A 2.41 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 57 - 671 0 TPO517 None cGMP-dependent protein kinase 1
7LV3B 2.41 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 58 - 671 0 TPO517 None cGMP-dependent protein kinase 1
7T4VB 2.28 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EXZ Allosteric 205 - 671 0 TPO517 None cGMP-dependent protein kinase 1
AF-Q13976-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 352 - 627 0 None None cGMP-dependent protein kinase 1
AF-Q13976-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 352 - 627 0 None None cGMP-dependent protein kinase 1
7T4UA 1.99 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EX6 Allosteric 205 - 671 0 TPO517 None cGMP-dependent protein kinase 1
7T4UB 1.99 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EX6 Allosteric 205 - 671 0 TPO517 None cGMP-dependent protein kinase 1
7T4WA 2.23 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EZJ Allosteric 205 - 671 0 TPO517 None cGMP-dependent protein kinase 1
7T4WB 2.23 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EZJ Allosteric 205 - 671 0 TPO517 None cGMP-dependent protein kinase 1
7T4TA 2.08 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii PCG, ATP Allosteric, ATPlike 204 - 671 0 TPO517 None cGMP-dependent protein kinase 1
7T4TB 2.08 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii PCG, ATP Allosteric, ATPlike 204 - 671 0 TPO517 None cGMP-dependent protein kinase 1
7T4VA 2.28 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iiio EXZ Allosteric 205 - 671 0 TPO517 None cGMP-dependent protein kinase 1
6BDLA 1.96 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaini APEdist_iiio No_ligand No_ligand 337 - 671 0 TPO517 None cGMP-dependent protein kinase 1
6C0TA 1.98 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii EE4 Type1.5_Front 337 - 671 0 TPO517 None cGMP-dependent protein kinase 1
6BDLB 1.96 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaini APEdist_iiii No_ligand No_ligand 337 - 671 0 TPO517 None cGMP-dependent protein kinase 1

AGC_PRKG1 (cGMP-dependent protein kinase 1)

Total number of chains: 19
Active chains: 9
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 13 68.4% AF-Q13976-K1A
DFGin ABAminus 6 31.6% 7T4UA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
KGP1_HUMAN 6BG2A 1.83 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 336 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
KGP1_HUMAN 6BG2B 1.83 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 346 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
KGP1_HUMAN 6BG2C 1.83 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 337 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
KGP1_HUMAN 6BG2D 1.83 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 344 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
KGP1_HUMAN 7LV3A 2.41 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 57 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
KGP1_HUMAN 7LV3B 2.41 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ANP ATPlike 58 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
KGP1_HUMAN 7T4VB 2.28 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EXZ Allosteric 205 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
KGP1_HUMAN AF-Q13976-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 352 - 627 0 None None cGMP-dependent protein kinase 1 Homo sapiens
KGP1_HUMAN AF-Q13976-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 352 - 627 0 None None cGMP-dependent protein kinase 1 Homo sapiens
KGP1_HUMAN 7T4UA 1.99 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EX6 Allosteric 205 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
KGP1_HUMAN 7T4UB 1.99 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EX6 Allosteric 205 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
KGP1_HUMAN 7T4WA 2.23 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EZJ Allosteric 205 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
KGP1_HUMAN 7T4WB 2.23 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii EZJ Allosteric 205 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
KGP1_HUMAN 7T4TA 2.08 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii PCG, ATP Allosteric, ATPlike 204 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
KGP1_HUMAN 7T4TB 2.08 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii PCG, ATP Allosteric, ATPlike 204 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
KGP1_HUMAN 7T4VA 2.28 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iiio EXZ Allosteric 205 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
KGP1_HUMAN 6BDLA 1.96 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaini APEdist_iiio No_ligand No_ligand 337 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
KGP1_HUMAN 6C0TA 1.98 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii EE4 Type1.5_Front 337 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens
KGP1_HUMAN 6BDLB 1.96 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaini APEdist_iiii No_ligand No_ligand 337 - 671 0 TPO517 None cGMP-dependent protein kinase 1 Homo sapiens

AGC_PRKG1 (cGMP-dependent protein kinase 1)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism