KIT (Mast/stem cell growth factor receptor Kit)

Group: TYR
Uniprot: KIT_HUMAN
Domain boundary: 589 - 926


Total number of chains: 52
Spatial Dihedral Chains Representative
DFGin BLAminus 21 AF-P10721-K1A
DFGout BBAminus 28 6MOBA
DFGout None 2 3G0EA
None None 1 8PQEA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-P10721-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 581 - 934 None None 0
7KHJA 2.8 Active DFGin BLAminus in-in in-in WEG Type1 566 - 931 None None 2
7KHJB 2.8 Active DFGin BLAminus in-in in-in WEG Type1 571 - 930 None None 3
7KHKA 2.34 Active DFGin BLAminus in-in in-in WEJ Type1 566 - 931 None None 2
8PQGA 2.4 Active DFGin BLAminus in-in in-in 9JI Type1 566 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,T670I,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 5
8PQGC 2.4 Active DFGin BLAminus in-in in-in 9JI Type1 565 - 932 I563S,V569S,Y609Q,L631S,M651E,I662H,T670I,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
8PQ9A 1.7 Active DFGin BLAminus in-in in-in 9JI Type1 566 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
8PQ9C 1.7 Active DFGin BLAminus in-in in-in 9JI Type1 565 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
8PQAA 1.65 Active DFGin BLAminus in-in in-in 98A Type1 566 - 930 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
8PQAC 1.65 Active DFGin BLAminus in-in in-in 98A Type1 566 - 932 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
8PQBA 1.87 Active DFGin BLAminus in-in in-in 9XO Type1 567 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 11
8PQCA 1.77 Active DFGin BLAminus in-in in-in 9OO Type1 566 - 932 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 2
8PQCB 1.77 Active DFGin BLAminus in-in in-in 9OO Type1 566 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 1
8PQDA 1.5 Active DFGin BLAminus in-in in-in 9VV Type1 566 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
8PQDB 1.5 Active DFGin BLAminus in-in in-in 9VV Type1 566 - 932 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
8PQEB 2.0 Active DFGin BLAminus in-in in-in 9WU Type1 566 - 930 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 13
8PQFA 1.9 Active DFGin BLAminus in-in in-in 9KI Type1 566 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 2
8PQFC 1.9 Active DFGin BLAminus in-in in-in 9KI Type1 566 - 932 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 2
1PKGA 2.9 Inactive DFGin BLAminus in-out in-in ADP Type1 567 - 927 None X568,X570 0
1PKGB 2.9 Active DFGin BLAminus in-in in-in ADP Type1 566 - 929 None X568,X570 13
7KHKB 2.34 Active DFGin BLAminus in-in in-in WEJ Type1.5_Back 567 - 929 None None 2
3G0FA 2.6 Inactive DFGout BBAminus in-in out-in B49 Type1 566 - 930 D816H None 0
3G0FB 2.6 Inactive DFGout BBAminus in-in out-in B49 Type1 564 - 930 D816H None 0
7ZW8A 2.119 Inactive DFGout BBAminus in-out out-in K3R Type1 554 - 932 None None 0
6KLAA 2.109 Inactive DFGout BBAminus in-in out-in DJX Type1 554 - 931 None None 0
4HVSA 1.9 Inactive DFGout BBAminus in-in out-in 647 Type2 551 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,I690H,C691S,K693D,Q694T,E695S,I756S,L762N,V825D,C844S,L890S,L912D,L923D None 0
7KHGA 2.15 Inactive DFGout BBAminus in-in out-in P31 Type2 547 - 931 None None 0
6GQJA 2.33 Inactive DFGout BBAminus in-in out-in F82 Type2 567 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
6GQJB 2.33 Inactive DFGout BBAminus in-in out-in F82 Type2 572 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
6GQKA 2.31 Inactive DFGout BBAminus in-in out-out F88 Type2 567 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
6GQKB 2.31 Inactive DFGout BBAminus in-in out-out F88 Type2 572 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
6GQLA 2.01 Inactive DFGout BBAminus in-in out-in F8B Type2 568 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
6GQLB 2.01 Inactive DFGout BBAminus in-in out-out F8B Type2 577 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
6GQMA 2.0 Inactive DFGout BBAminus in-in out-in F8H Type2 569 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
6GQMB 2.0 Inactive DFGout BBAminus in-in out-in F8H Type2 577 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
6XV9A 3.38 Inactive DFGout BBAminus in-in out-in O35 Type2 566 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
6XV9B 3.38 Inactive DFGout BBAminus in-in out-in O35 Type2 572 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
6XVAA 2.3 Inactive DFGout BBAminus in-in out-in O2K Type2 569 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
6XVAB 2.3 Inactive DFGout BBAminus in-in out-in O2K Type2 577 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
6XVBA 2.15 Inactive DFGout BBAminus in-in out-in O2H Type2 569 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
6XVBB 2.15 Inactive DFGout BBAminus in-in out-in O2H Type2 577 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
6HH1A 2.25 Inactive DFGout BBAminus in-in none-none G4E Type2 565 - 929 None None 0
6MOBA 1.8 Inactive DFGout BBAminus in-in out-in JWY Type2 567 - 930 None None 0
1T46A 1.6 Inactive DFGout BBAminus in-in out-in STI Type2 565 - 933 None None 0
4U0IA 2.0 Inactive DFGout BBAminus in-in out-in 0LI Type2 565 - 933 None None 0
7ZY6A 3.09 Inactive DFGout BBAminus in-out out-in KCI Type2 557 - 932 None None 0
6ITTA 2.103 Inactive DFGout BBAminus in-in out-in AWO Type2 563 - 932 None None 0
6ITTB 2.103 Inactive DFGout BBAminus in-in out-in AWO Type2 566 - 932 None None 0
6ITVA 1.881 Inactive DFGout BBAminus in-in out-in AWO Type2 569 - 935 None X570 0
1T45A 1.9 Inactive DFGout None in-in out-in No_ligand No_ligand 547 - 935 None None 0
3G0EA 1.6 Inactive DFGout None in-in out-in B49 Type1 544 - 931 None None 0
8PQEA 2.0 Inactive None None in-in none-in 9WU Type1 566 - 930 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 19

KIT (Mast/stem cell growth factor receptor Kit)

Group: TYR
Total number of chains: 52
Spatial Dihedral Chains Representative
DFGin BLAminus 21 AF-P10721-K1A
DFGout BBAminus 28 6MOBA
DFGout None 2 3G0EA
None None 1 8PQEA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens KIT_HUMAN AF-P10721-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 581 - 934 None None 0
Homo sapiens KIT_HUMAN 7KHJA 2.8 Active DFGin BLAminus in-in in-in WEG Type1 566 - 931 None None 2
Homo sapiens KIT_HUMAN 7KHJB 2.8 Active DFGin BLAminus in-in in-in WEG Type1 571 - 930 None None 3
Homo sapiens KIT_HUMAN 7KHKA 2.34 Active DFGin BLAminus in-in in-in WEJ Type1 566 - 931 None None 2
Homo sapiens KIT_HUMAN 8PQGA 2.4 Active DFGin BLAminus in-in in-in 9JI Type1 566 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,T670I,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 5
Homo sapiens KIT_HUMAN 8PQGC 2.4 Active DFGin BLAminus in-in in-in 9JI Type1 565 - 932 I563S,V569S,Y609Q,L631S,M651E,I662H,T670I,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
Homo sapiens KIT_HUMAN 8PQ9A 1.7 Active DFGin BLAminus in-in in-in 9JI Type1 566 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
Homo sapiens KIT_HUMAN 8PQ9C 1.7 Active DFGin BLAminus in-in in-in 9JI Type1 565 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
Homo sapiens KIT_HUMAN 8PQAA 1.65 Active DFGin BLAminus in-in in-in 98A Type1 566 - 930 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
Homo sapiens KIT_HUMAN 8PQAC 1.65 Active DFGin BLAminus in-in in-in 98A Type1 566 - 932 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
Homo sapiens KIT_HUMAN 8PQBA 1.87 Active DFGin BLAminus in-in in-in 9XO Type1 567 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 11
Homo sapiens KIT_HUMAN 8PQCA 1.77 Active DFGin BLAminus in-in in-in 9OO Type1 566 - 932 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 2
Homo sapiens KIT_HUMAN 8PQCB 1.77 Active DFGin BLAminus in-in in-in 9OO Type1 566 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 1
Homo sapiens KIT_HUMAN 8PQDA 1.5 Active DFGin BLAminus in-in in-in 9VV Type1 566 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
Homo sapiens KIT_HUMAN 8PQDB 1.5 Active DFGin BLAminus in-in in-in 9VV Type1 566 - 932 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
Homo sapiens KIT_HUMAN 8PQEB 2.0 Active DFGin BLAminus in-in in-in 9WU Type1 566 - 930 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 13
Homo sapiens KIT_HUMAN 8PQFA 1.9 Active DFGin BLAminus in-in in-in 9KI Type1 566 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 2
Homo sapiens KIT_HUMAN 8PQFC 1.9 Active DFGin BLAminus in-in in-in 9KI Type1 566 - 932 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 2
Homo sapiens KIT_HUMAN 1PKGA 2.9 Inactive DFGin BLAminus in-out in-in ADP Type1 567 - 927 None X568,X570 0
Homo sapiens KIT_HUMAN 1PKGB 2.9 Active DFGin BLAminus in-in in-in ADP Type1 566 - 929 None X568,X570 13
Homo sapiens KIT_HUMAN 7KHKB 2.34 Active DFGin BLAminus in-in in-in WEJ Type1.5_Back 567 - 929 None None 2
Homo sapiens KIT_HUMAN 3G0FA 2.6 Inactive DFGout BBAminus in-in out-in B49 Type1 566 - 930 D816H None 0
Homo sapiens KIT_HUMAN 3G0FB 2.6 Inactive DFGout BBAminus in-in out-in B49 Type1 564 - 930 D816H None 0
Homo sapiens KIT_HUMAN 7ZW8A 2.119 Inactive DFGout BBAminus in-out out-in K3R Type1 554 - 932 None None 0
Homo sapiens KIT_HUMAN 6KLAA 2.109 Inactive DFGout BBAminus in-in out-in DJX Type1 554 - 931 None None 0
Homo sapiens KIT_HUMAN 4HVSA 1.9 Inactive DFGout BBAminus in-in out-in 647 Type2 551 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,I690H,C691S,K693D,Q694T,E695S,I756S,L762N,V825D,C844S,L890S,L912D,L923D None 0
Homo sapiens KIT_HUMAN 7KHGA 2.15 Inactive DFGout BBAminus in-in out-in P31 Type2 547 - 931 None None 0
Homo sapiens KIT_HUMAN 6GQJA 2.33 Inactive DFGout BBAminus in-in out-in F82 Type2 567 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
Homo sapiens KIT_HUMAN 6GQJB 2.33 Inactive DFGout BBAminus in-in out-in F82 Type2 572 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
Homo sapiens KIT_HUMAN 6GQKA 2.31 Inactive DFGout BBAminus in-in out-out F88 Type2 567 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
Homo sapiens KIT_HUMAN 6GQKB 2.31 Inactive DFGout BBAminus in-in out-out F88 Type2 572 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
Homo sapiens KIT_HUMAN 6GQLA 2.01 Inactive DFGout BBAminus in-in out-in F8B Type2 568 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
Homo sapiens KIT_HUMAN 6GQLB 2.01 Inactive DFGout BBAminus in-in out-out F8B Type2 577 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
Homo sapiens KIT_HUMAN 6GQMA 2.0 Inactive DFGout BBAminus in-in out-in F8H Type2 569 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
Homo sapiens KIT_HUMAN 6GQMB 2.0 Inactive DFGout BBAminus in-in out-in F8H Type2 577 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
Homo sapiens KIT_HUMAN 6XV9A 3.38 Inactive DFGout BBAminus in-in out-in O35 Type2 566 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
Homo sapiens KIT_HUMAN 6XV9B 3.38 Inactive DFGout BBAminus in-in out-in O35 Type2 572 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
Homo sapiens KIT_HUMAN 6XVAA 2.3 Inactive DFGout BBAminus in-in out-in O2K Type2 569 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
Homo sapiens KIT_HUMAN 6XVAB 2.3 Inactive DFGout BBAminus in-in out-in O2K Type2 577 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
Homo sapiens KIT_HUMAN 6XVBA 2.15 Inactive DFGout BBAminus in-in out-in O2H Type2 569 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
Homo sapiens KIT_HUMAN 6XVBB 2.15 Inactive DFGout BBAminus in-in out-in O2H Type2 577 - 931 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 0
Homo sapiens KIT_HUMAN 6HH1A 2.25 Inactive DFGout BBAminus in-in none-none G4E Type2 565 - 929 None None 0
Homo sapiens KIT_HUMAN 6MOBA 1.8 Inactive DFGout BBAminus in-in out-in JWY Type2 567 - 930 None None 0
Homo sapiens KIT_HUMAN 1T46A 1.6 Inactive DFGout BBAminus in-in out-in STI Type2 565 - 933 None None 0
Homo sapiens KIT_HUMAN 4U0IA 2.0 Inactive DFGout BBAminus in-in out-in 0LI Type2 565 - 933 None None 0
Homo sapiens KIT_HUMAN 7ZY6A 3.09 Inactive DFGout BBAminus in-out out-in KCI Type2 557 - 932 None None 0
Homo sapiens KIT_HUMAN 6ITTA 2.103 Inactive DFGout BBAminus in-in out-in AWO Type2 563 - 932 None None 0
Homo sapiens KIT_HUMAN 6ITTB 2.103 Inactive DFGout BBAminus in-in out-in AWO Type2 566 - 932 None None 0
Homo sapiens KIT_HUMAN 6ITVA 1.881 Inactive DFGout BBAminus in-in out-in AWO Type2 569 - 935 None X570 0
Homo sapiens KIT_HUMAN 1T45A 1.9 Inactive DFGout None in-in out-in No_ligand No_ligand 547 - 935 None None 0
Homo sapiens KIT_HUMAN 3G0EA 1.6 Inactive DFGout None in-in out-in B49 Type1 544 - 931 None None 0
Homo sapiens KIT_HUMAN 8PQEA 2.0 Inactive None None in-in none-in 9WU Type1 566 - 930 I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D None 19

KIT (Mast/stem cell growth factor receptor Kit)

No non-human structures known.