AGC_PDPK1 (3-phosphoinositide-dependent protein kinase 1)

Total number of chains: 82
Active chains: 28
Uniprot: PDPK1_HUMAN
Kinase Domain Residues: 82 - 342
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 79 96.3% AF-O15530-K1A
DFGout BBAminus 2 2.4% 3NAXA
DFGout None 1 1.2% 3QC4B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
2BIYA 1.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 72 - 359 0 None S241A 3-phosphoinositide-dependent protein kinase 1
3HRCA 1.91 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 76 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
4RRVA 1.412 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 76 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
5ACKA 1.24 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 73 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
5LVPA 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 75 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
5LVPB 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 74 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
5LVPC 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 75 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
5LVPD 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 74 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
4CT2A 1.25 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 75 - 359 0 SEP241 L113V,I118V,I119H,V124I,T128Q,R131K,T148C,F157L,Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
5MRDA 1.41 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 76 - 359 0 SEP241 K76S,L113V,I118V,I119N,V124I,T128Q,R131K,T148C 3-phosphoinositide-dependent protein kinase 1
3HRFA 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, P47 ATPlike, Allosteric 75 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
4A06A 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, A06 ATPlike, Allosteric 75 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
4AW0A 1.43 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, MJF ATPlike, Allosteric 75 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
4AW1A 1.68 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, 21O ATPlike, Allosteric 66 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
4RQKA 1.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, R1S ATPlike, Allosteric 74 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
4RQVA 1.502 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, R2S ATPlike, Allosteric 71 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
5LVOA 1.09 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, 78W ATPlike, Allosteric 73 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
4XX9A 1.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, RF4, RF4 ATPlike, Allosteric, Allosteric 71 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
4A07A 1.85 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, AZ7, AZ7 ATPlike, Allosteric, Allosteric 75 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
8DQTA 1.31 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii U35, U35, U35 Allosteric, Allosteric, Allosteric 70 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
3OTUA 2.101 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii J30, BI4 Allosteric, Type1.5_Front 77 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1
AF-O15530-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 74 - 350 0 None None 3-phosphoinositide-dependent protein kinase 1
AF-O15530-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 74 - 350 0 None None 3-phosphoinositide-dependent protein kinase 1
3SC1A 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 3S1 Type1 73 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
3RCJA 1.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 3RC Type1 77 - 358 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
5LVLA 1.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 537 Type1 74 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
5LVMA 1.26 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADE Type1 76 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
5LVNA 1.379 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADN Type1 75 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
1H1WA 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ATP ATPlike 71 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
3ORXA 2.204 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 1F8 Allosteric 75 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1
3ORXB 2.204 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 1F8 Allosteric 77 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1
3ORXC 2.204 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 1F8 Allosteric 75 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1
3ORXD 2.204 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 1F8 Allosteric 76 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1
3ORXE 2.204 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooi 1F8 Allosteric 76 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1
3ORXF 2.204 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaiii APEdist_iooi 1F8 Allosteric 75 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1
3ORXG 2.204 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 1F8 Allosteric 75 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1
3ORXH 2.204 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 1F8 Allosteric 75 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1
3ORZA 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 2A2, BI4 Allosteric, Type1 74 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1
3ORZB 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 2A2, BI4 Allosteric, Type1 73 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1
3ORZC 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 2A2, BI4 Allosteric, Type1 74 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1
3ORZD 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 2A2, BI4 Allosteric, Type1 73 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1
1Z5MA 2.17 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi LI8 Type1 74 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
2PE0A 2.35 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 39Z Type1 74 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
2PE1A 2.14 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 517 Type1 74 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
2PE2A 2.13 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 464 Type1 74 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
3NUSA 2.75 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi JNZ Type1 73 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
3NUUA 1.98 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi JOZ Type1 73 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
3NUYA 2.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi JPZ Type1 73 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
1UU9A 1.95 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi BI3 Type1 72 - 357 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
1UVRA 2.81 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi BI8 Type1 71 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
3NUNA 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi JMZ Type1 71 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
2XCHA 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi CKG Type1 73 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
5HKMA 2.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 61Y Type1 76 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
5HNGA 3.01 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 62O Type1 71 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
5HO7A 3.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 63L Type1 71 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
5HO8A 2.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 63E Type1 71 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
1OKYA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi STU Type1 72 - 360 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
1OKZA 2.51 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi UCN Type1 73 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
1UU3A 1.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi LY4 Type1 73 - 360 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
1UU7A 1.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi BI2 Type1 73 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
1UU8A 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi BI1 Type1 72 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
3NAYA 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi MP6 Type1 76 - 362 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
3NAYB 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi MP6 Type1 76 - 362 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
3RWPA 1.92 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ABQ Type1 73 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
3RWQA 2.55 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 3RW Type1 72 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
3H9OA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9BD Type1 75 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
2R7BA 2.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 253 Type1 75 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
3IONA 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnoi 8H1 Type1 75 - 359 0 None None 3-phosphoinositide-dependent protein kinase 1
3IOPA 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 8I1 Type1 75 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
3QCQA 2.501 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 3Q0 Type1 73 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
3QCSA 2.487 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 3Q1 Type1 73 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
3PWYA 3.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi SYP Type1 71 - 359 0 None E166C,C260S 3-phosphoinositide-dependent protein kinase 1
2XCKA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi MH4 Type1 76 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
3QCXA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 3Q2 Type1.5_Back 73 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
3QCYA 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnoi 3Q3 Type1.5_Front 73 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
3QD3A 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 3Q5 Type1.5_Front 71 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
3NAXA 1.75 Inactive DFGout‑BBAminus out-out in-none nonTYR APEdihe_aannn APEdist_nnnn MP7 Type2 76 - 360 0 None None 3-phosphoinositide-dependent protein kinase 1
3QC4A 1.8 Inactive DFGout‑BBAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii MP7 Type2 76 - 359 0 SEP241 E303A,K304A 3-phosphoinositide-dependent protein kinase 1
3QC4B 1.8 Inactive DFGout‑None out-out in-in nonTYR APEdihe_aaiii APEdist_iiii MP7 Type2 51 - 359 0 SEP241 E303A,K304A 3-phosphoinositide-dependent protein kinase 1
4CT1A 1.85 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, 31S ATPlike, Allosteric 76 - 359 0 SEP241 L113V,I118V,I119H,V124I,T128Q,R131K,T148C,F157L,Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
3QD0A 1.99 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnni 3Q4 Type1.5_Front 73 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1
3QD4A 2.3 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnni 3Q6 Type1.5_Front 71 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1

AGC_PDPK1 (3-phosphoinositide-dependent protein kinase 1)

Total number of chains: 82
Active chains: 28
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 79 96.3% AF-O15530-K1A
DFGout BBAminus 2 2.4% 3NAXA
DFGout None 1 1.2% 3QC4B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
PDPK1_HUMAN 2BIYA 1.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 72 - 359 0 None S241A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3HRCA 1.91 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 76 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 4RRVA 1.412 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 76 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 5ACKA 1.24 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 73 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 5LVPA 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 75 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 5LVPB 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 74 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 5LVPC 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 75 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 5LVPD 2.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 74 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 4CT2A 1.25 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 75 - 359 0 SEP241 L113V,I118V,I119H,V124I,T128Q,R131K,T148C,F157L,Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 5MRDA 1.41 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP ATPlike 76 - 359 0 SEP241 K76S,L113V,I118V,I119N,V124I,T128Q,R131K,T148C 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3HRFA 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, P47 ATPlike, Allosteric 75 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 4A06A 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, A06 ATPlike, Allosteric 75 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 4AW0A 1.43 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, MJF ATPlike, Allosteric 75 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 4AW1A 1.68 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, 21O ATPlike, Allosteric 66 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 4RQKA 1.55 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, R1S ATPlike, Allosteric 74 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 4RQVA 1.502 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, R2S ATPlike, Allosteric 71 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 5LVOA 1.09 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, 78W ATPlike, Allosteric 73 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 4XX9A 1.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, RF4, RF4 ATPlike, Allosteric, Allosteric 71 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 4A07A 1.85 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, AZ7, AZ7 ATPlike, Allosteric, Allosteric 75 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 8DQTA 1.31 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii U35, U35, U35 Allosteric, Allosteric, Allosteric 70 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3OTUA 2.101 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii J30, BI4 Allosteric, Type1.5_Front 77 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN AF-O15530-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 74 - 350 0 None None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN AF-O15530-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 74 - 350 0 None None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3SC1A 2.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 3S1 Type1 73 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3RCJA 1.7 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 3RC Type1 77 - 358 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 5LVLA 1.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 537 Type1 74 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 5LVMA 1.26 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADE Type1 76 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 5LVNA 1.379 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ADN Type1 75 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 1H1WA 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ATP ATPlike 71 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3ORXA 2.204 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 1F8 Allosteric 75 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3ORXB 2.204 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 1F8 Allosteric 77 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3ORXC 2.204 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 1F8 Allosteric 75 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3ORXD 2.204 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 1F8 Allosteric 76 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3ORXE 2.204 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooi 1F8 Allosteric 76 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3ORXF 2.204 Inactive DFGin‑BLAminus in-none in-out nonTYR APEdihe_aaiii APEdist_iooi 1F8 Allosteric 75 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3ORXG 2.204 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 1F8 Allosteric 75 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3ORXH 2.204 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 1F8 Allosteric 75 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3ORZA 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 2A2, BI4 Allosteric, Type1 74 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3ORZB 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 2A2, BI4 Allosteric, Type1 73 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3ORZC 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 2A2, BI4 Allosteric, Type1 74 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3ORZD 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 2A2, BI4 Allosteric, Type1 73 - 359 0 SEP241 T148C 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 1Z5MA 2.17 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi LI8 Type1 74 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 2PE0A 2.35 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 39Z Type1 74 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 2PE1A 2.14 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 517 Type1 74 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 2PE2A 2.13 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 464 Type1 74 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3NUSA 2.75 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi JNZ Type1 73 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3NUUA 1.98 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi JOZ Type1 73 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3NUYA 2.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi JPZ Type1 73 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 1UU9A 1.95 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi BI3 Type1 72 - 357 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 1UVRA 2.81 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi BI8 Type1 71 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3NUNA 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi JMZ Type1 71 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 2XCHA 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi CKG Type1 73 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 5HKMA 2.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 61Y Type1 76 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 5HNGA 3.01 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 62O Type1 71 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 5HO7A 3.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 63L Type1 71 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 5HO8A 2.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 63E Type1 71 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 1OKYA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi STU Type1 72 - 360 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 1OKZA 2.51 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi UCN Type1 73 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 1UU3A 1.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi LY4 Type1 73 - 360 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 1UU7A 1.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi BI2 Type1 73 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 1UU8A 2.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi BI1 Type1 72 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3NAYA 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi MP6 Type1 76 - 362 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3NAYB 2.6 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi MP6 Type1 76 - 362 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3RWPA 1.92 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi ABQ Type1 73 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3RWQA 2.55 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 3RW Type1 72 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3H9OA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9BD Type1 75 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 2R7BA 2.7 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 253 Type1 75 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3IONA 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnoi 8H1 Type1 75 - 359 0 None None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3IOPA 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 8I1 Type1 75 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3QCQA 2.501 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 3Q0 Type1 73 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3QCSA 2.487 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 3Q1 Type1 73 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3PWYA 3.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi SYP Type1 71 - 359 0 None E166C,C260S 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 2XCKA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi MH4 Type1 76 - 359 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3QCXA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 3Q2 Type1.5_Back 73 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3QCYA 2.2 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnoi 3Q3 Type1.5_Front 73 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3QD3A 2.0 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 3Q5 Type1.5_Front 71 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3NAXA 1.75 Inactive DFGout‑BBAminus out-out in-none nonTYR APEdihe_aannn APEdist_nnnn MP7 Type2 76 - 360 0 None None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3QC4A 1.8 Inactive DFGout‑BBAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii MP7 Type2 76 - 359 0 SEP241 E303A,K304A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3QC4B 1.8 Inactive DFGout‑None out-out in-in nonTYR APEdihe_aaiii APEdist_iiii MP7 Type2 51 - 359 0 SEP241 E303A,K304A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 4CT1A 1.85 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, 31S ATPlike, Allosteric 76 - 359 0 SEP241 L113V,I118V,I119H,V124I,T128Q,R131K,T148C,F157L,Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3QD0A 1.99 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnni 3Q4 Type1.5_Front 73 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
PDPK1_HUMAN 3QD4A 2.3 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnni 3Q6 Type1.5_Front 71 - 358 0 SEP241 None 3-phosphoinositide-dependent protein kinase 1 Homo sapiens

AGC_PDPK1 (3-phosphoinositide-dependent protein kinase 1)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism