Ligand: IE0

Total number of chains: 2
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 9FQSA
DFGout None 1 50.0% 8PYLAAA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TYR EGFR EGFR_HUMAN 9FQSA 1.783 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai A1IE0 Type1.5_Back 701 - 1019 0 None V948R Epidermal growth factor receptor
TYR IGF1R IGF1R_HUMAN 8PYLAAA 2.93 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai IE0 Type2 986 - 1270 0 None None Insulin-like growth factor 1 receptor

Ligand: IE0

Total number of chains: 2
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 1 50.0% 9FQSA
DFGout None 1 50.0% 8PYLAAA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYR EGFR EGFR_HUMAN 9FQSA 1.783 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai A1IE0 Type1.5_Back 701 - 1019 0 None V948R Epidermal growth factor receptor Homo sapiens
TYR IGF1R IGF1R_HUMAN 8PYLAAA 2.93 Inactive DFGout‑None out-out out-in TYR APEdihe_iiiai APEdist_aaai IE0 Type2 986 - 1270 0 None None Insulin-like growth factor 1 receptor Homo sapiens

Ligand: IE0

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism