8YP4

MAP2K1 (Dual specificity mitogen-activated protein kinase kinase 1)
Group: STE
Uniprot: MP2K1_HUMAN
Organism: Homo sapiens
Domain boundary: 68 - 361
Resolu: 2.35

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin None out-out out-out WNT Type1 34 - 384 9
B Inactive DFGout None out-out out-none WNT Type1 43 - 383 11
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain B
        42         52         62         72 
mqkkleelel DEQQRKRLEA FLTQKQKVGE LKDDDFEKIS 
        82         92        102        112 
ELGAGNGGVV FKVSHKPSGL VMARKLIHLE IKPAIRNQII 
       122        132        142        152 
RELQVLHECN SPYIVGFYGA FYSDGEISIC MEHMDGGSLD 
       162        172        182        192 
QVLKKAGRIP EQILGKVSIA VIKGLTYLRE KHKIMHRDVK 
       202        212        222        232 
PSNILVNSRG EIKLCDFGVS GQlidsmans fvgTRSYMSP 
       242        252        262        272 
ERLQgtHYSV QSDIWSMGLS LVEMAVGRYP IPPPDAKELE 
       282        292        302        312 
LMFGCqvegd aaeapprpra pgrplasygm dsrpPMAIFE 
       322        332        342        352 
LLDYIVNEPP PKLPSGVFSL EFQDFVNKCL IKNPAERADL 
       362        372        382          - 
KQLMVHAFIK RSDAEEVDFA GWLCSTIGLN Qpstaaaleh 

hhhhh
Lower-case residues are disordered in structure.
Mutations: T286A,T292A,S298A
Phosphorylation: None