OTHER_MLKL (Mixed lineage kinase domain-like protein)

Total number of chains: 15
Uniprot: MLKL_HUMAN
Kinase Domain Residues: 201 - 468
Spatial label Dihedral label Number of Chains Representative
DFGin BLAminus 1 6O5ZA
DFGin BLAplus 3 7JXUA
DFGin BLBminus 8 4MWIA
DFGout None 1 6O5ZB
None None 2 5KNJB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
6O5ZA 2.285 Pseudo DFGin‑BLAminus in-in out-out No_ligand No_ligand 191 - 470 9 None None Mixed lineage kinase domain-like protein
7JXUA 2.44 Pseudo DFGin‑BLAplus out-out out-out No_ligand No_ligand 191 - 471 0 None None Mixed lineage kinase domain-like protein
7JXUB 2.44 Pseudo DFGin‑BLAplus out-out out-out No_ligand No_ligand 191 - 471 0 None None Mixed lineage kinase domain-like protein
7MONA 2.23 Pseudo DFGin‑BLAplus out-out out-out ZL1 Type1 191 - 469 8 None None Mixed lineage kinase domain-like protein
4MWIA 1.7 Pseudo DFGin‑BLBminus in-in out-out PXN Allosteric 193 - 470 12 None None Mixed lineage kinase domain-like protein
6BWKA 2.79 Pseudo DFGin‑BLBminus in-none none-out No_ligand No_ligand 192 - 470 16 None T357E,S358E Mixed lineage kinase domain-like protein
7JW7A 2.63 Pseudo DFGin‑BLBminus in-in none-out No_ligand No_ligand 191 - 470 19 None None Mixed lineage kinase domain-like protein
8SLZA 2.3 Pseudo DFGin‑BLBminus in-in out-out No_ligand No_ligand 191 - 469 14 X357,X358 None Mixed lineage kinase domain-like protein
4M67A 1.9 Pseudo DFGin‑BLBminus in-in out-out No_ligand No_ligand 192 - 469 14 None None Mixed lineage kinase domain-like protein
6LK6A 2.41 Pseudo DFGin‑BLBminus in-in out-out No_ligand No_ligand 192 - 470 14 None T357A,S358A Mixed lineage kinase domain-like protein
6LK5A 2.5 Pseudo DFGin‑BLBminus in-in out-out No_ligand No_ligand 192 - 470 14 None T357E,S358D Mixed lineage kinase domain-like protein
5KO1A 2.16 Pseudo DFGin‑BLBminus in-in out-out 6UY Type1 192 - 470 14 None E366A,K367A Mixed lineage kinase domain-like protein
6O5ZB 2.285 Pseudo DFGout‑None in-out none-out LN4 Type2 190 - 467 12 None None Mixed lineage kinase domain-like protein
5KNJA 2.88 Pseudo None‑None in-in none-out 6UX Type1 193 - 468 18 None E366A,K367A Mixed lineage kinase domain-like protein
5KNJB 2.88 Pseudo None‑None in-in none-out 6UX Type1 192 - 469 19 None E366A,K367A Mixed lineage kinase domain-like protein

OTHER_MLKL (Mixed lineage kinase domain-like protein)

Total number of chains: 23
Spatial label Dihedral label Number of Chains Representative
DFGin BLAminus 1 6O5ZA
DFGin BLAplus 5 7JXUA
DFGin BLBminus 13 6VC0A
DFGout None 1 6O5ZB
None None 3 4M69B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
F6S337_HORSE 6VC0A 2.746 Pseudo DFGin‑BLBminus in-in out-out No_ligand No_ligand 258 - 536 7 None None Mixed lineage kinase domain like pseudokinase Equus caballus
F6S337_HORSE 6VC0B 2.746 Pseudo DFGin‑BLBminus in-in out-out No_ligand No_ligand 258 - 537 11 None None Mixed lineage kinase domain like pseudokinase Equus caballus
F6S337_HORSE 6VC0C 2.746 Pseudo DFGin‑BLBminus in-in out-out No_ligand No_ligand 258 - 541 8 None None Mixed lineage kinase domain like pseudokinase Equus caballus
MLKL_HUMAN 6O5ZA 2.285 Pseudo DFGin‑BLAminus in-in out-out No_ligand No_ligand 191 - 470 9 None None Mixed lineage kinase domain-like protein Homo sapiens
MLKL_HUMAN 7JXUA 2.44 Pseudo DFGin‑BLAplus out-out out-out No_ligand No_ligand 191 - 471 0 None None Mixed lineage kinase domain-like protein Homo sapiens
MLKL_HUMAN 7JXUB 2.44 Pseudo DFGin‑BLAplus out-out out-out No_ligand No_ligand 191 - 471 0 None None Mixed lineage kinase domain-like protein Homo sapiens
MLKL_HUMAN 7MONA 2.23 Pseudo DFGin‑BLAplus out-out out-out ZL1 Type1 191 - 469 8 None None Mixed lineage kinase domain-like protein Homo sapiens
MLKL_HUMAN 4MWIA 1.7 Pseudo DFGin‑BLBminus in-in out-out PXN Allosteric 193 - 470 12 None None Mixed lineage kinase domain-like protein Homo sapiens
MLKL_HUMAN 6BWKA 2.79 Pseudo DFGin‑BLBminus in-none none-out No_ligand No_ligand 192 - 470 16 None T357E,S358E Mixed lineage kinase domain-like protein Homo sapiens
MLKL_HUMAN 7JW7A 2.63 Pseudo DFGin‑BLBminus in-in none-out No_ligand No_ligand 191 - 470 19 None None Mixed lineage kinase domain-like protein Homo sapiens
MLKL_HUMAN 8SLZA 2.3 Pseudo DFGin‑BLBminus in-in out-out No_ligand No_ligand 191 - 469 14 X357,X358 None Mixed lineage kinase domain-like protein Homo sapiens
MLKL_HUMAN 4M67A 1.9 Pseudo DFGin‑BLBminus in-in out-out No_ligand No_ligand 192 - 469 14 None None Mixed lineage kinase domain-like protein Homo sapiens
MLKL_HUMAN 6LK6A 2.41 Pseudo DFGin‑BLBminus in-in out-out No_ligand No_ligand 192 - 470 14 None T357A,S358A Mixed lineage kinase domain-like protein Homo sapiens
MLKL_HUMAN 6LK5A 2.5 Pseudo DFGin‑BLBminus in-in out-out No_ligand No_ligand 192 - 470 14 None T357E,S358D Mixed lineage kinase domain-like protein Homo sapiens
MLKL_HUMAN 5KO1A 2.16 Pseudo DFGin‑BLBminus in-in out-out 6UY Type1 192 - 470 14 None E366A,K367A Mixed lineage kinase domain-like protein Homo sapiens
MLKL_HUMAN 6O5ZB 2.285 Pseudo DFGout‑None in-out none-out LN4 Type2 190 - 467 12 None None Mixed lineage kinase domain-like protein Homo sapiens
MLKL_HUMAN 5KNJA 2.88 Pseudo None‑None in-in none-out 6UX Type1 193 - 468 18 None E366A,K367A Mixed lineage kinase domain-like protein Homo sapiens
MLKL_HUMAN 5KNJB 2.88 Pseudo None‑None in-in none-out 6UX Type1 192 - 469 19 None E366A,K367A Mixed lineage kinase domain-like protein Homo sapiens
MLKL_MOUSE 4M68A 1.696 Pseudo DFGin‑BLAplus out-out out-out No_ligand No_ligand 182 - 466 9 None None Mixed lineage kinase domain-like protein Mus musculus
MLKL_MOUSE 4BTFA 2.604 Pseudo DFGin‑BLAplus out-out out-out No_ligand No_ligand 2 - 463 8 None None Mixed lineage kinase domain-like protein Mus musculus
MLKL_MOUSE 4M69B 2.497 Pseudo None‑None out-out out-out No_ligand No_ligand 182 - 466 13 None None Mixed lineage kinase domain-like protein Mus musculus
D3ZKP6_RAT 6VBZA 2.192 Pseudo DFGin‑BLBminus in-in none-out No_ligand No_ligand 183 - 454 16 None None Mixed lineage kinase domain-like protein Rattus norvegicus
D3ZKP6_RAT 6VBZB 2.192 Pseudo DFGin‑BLBminus in-in none-out No_ligand No_ligand 182 - 454 17 None None Mixed lineage kinase domain-like protein Rattus norvegicus

OTHER_MLKL (Mixed lineage kinase domain-like protein)

Total number of chains: 8
Spatial label Dihedral label Number of Chains Representative
DFGin BLAplus 2 4BTFA
DFGin BLBminus 5 6VC0A
None None 1 4M69B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
F6S337_HORSE 6VC0A 2.746 Pseudo DFGin‑BLBminus in-in out-out No_ligand No_ligand 258 - 536 7 None None Mixed lineage kinase domain like pseudokinase Equus caballus
F6S337_HORSE 6VC0B 2.746 Pseudo DFGin‑BLBminus in-in out-out No_ligand No_ligand 258 - 537 11 None None Mixed lineage kinase domain like pseudokinase Equus caballus
F6S337_HORSE 6VC0C 2.746 Pseudo DFGin‑BLBminus in-in out-out No_ligand No_ligand 258 - 541 8 None None Mixed lineage kinase domain like pseudokinase Equus caballus
MLKL_MOUSE 4M68A 1.696 Pseudo DFGin‑BLAplus out-out out-out No_ligand No_ligand 182 - 466 9 None None Mixed lineage kinase domain-like protein Mus musculus
MLKL_MOUSE 4BTFA 2.604 Pseudo DFGin‑BLAplus out-out out-out No_ligand No_ligand 2 - 463 8 None None Mixed lineage kinase domain-like protein Mus musculus
MLKL_MOUSE 4M69B 2.497 Pseudo None‑None out-out out-out No_ligand No_ligand 182 - 466 13 None None Mixed lineage kinase domain-like protein Mus musculus
D3ZKP6_RAT 6VBZA 2.192 Pseudo DFGin‑BLBminus in-in none-out No_ligand No_ligand 183 - 454 16 None None Mixed lineage kinase domain-like protein Rattus norvegicus
D3ZKP6_RAT 6VBZB 2.192 Pseudo DFGin‑BLBminus in-in none-out No_ligand No_ligand 182 - 454 17 None None Mixed lineage kinase domain-like protein Rattus norvegicus