Ligand: PDO

Total number of chains: 5
Active chains: 2
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 60.0% 9BY4A
DFGout BBAminus 1 20.0% 9CJ3A
DFGout None 1 20.0% 9CJ5A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
CAMK AURKA AURKA_HUMAN 8SSPA 2.6 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii PDO, 627 Allosteric, Type1 126 - 389 0 None None Aurora kinase A
CMGC MAPK14 MK14_HUMAN 9CJ3A 1.95 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_oioo PDO, A1AWV Allosteric, Type2 4 - 352 0 TPO180,PTR182 None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 9CJ5A 3.3 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nooo A1AWV, PDO Type2, Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14
TYR EGFR EGFR_HUMAN 9BY6A 2.551 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai PDO, Q6K Allosteric, Type1 698 - 1009 0 None None Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9BY4A 2.307 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai PDO, Q6K, PDO, PDO Allosteric, Type1, Allosteric, Type1 696 - 1010 0 None None Epidermal growth factor receptor

Ligand: PDO

Total number of chains: 6
Active chains: 2
Total number of genes: 4
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 3 50.0% 9BY4A
DFGin BLBminus 1 16.7% 4L68A
DFGout BBAminus 1 16.7% 9CJ3A
DFGout None 1 16.7% 9CJ5A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
OTHER BIR2 BIR2_ARATH 4L68A 2.0 Pseudo DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiai APEdist_nioi PDO Allosteric 272 - 600 0 None None Inactive LRR receptor-like serine/threonine-protein kinase BIR2 Arabidopsis thaliana
CAMK AURKA AURKA_HUMAN 8SSPA 2.6 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii PDO, 627 Allosteric, Type1 126 - 389 0 None None Aurora kinase A Homo sapiens
CMGC MAPK14 MK14_HUMAN 9CJ3A 1.95 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaoii APEdist_oioo PDO, A1AWV Allosteric, Type2 4 - 352 0 TPO180,PTR182 None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 9CJ5A 3.3 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nooo A1AWV, PDO Type2, Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
TYR EGFR EGFR_HUMAN 9BY6A 2.551 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai PDO, Q6K Allosteric, Type1 698 - 1009 0 None None Epidermal growth factor receptor Homo sapiens
TYR EGFR EGFR_HUMAN 9BY4A 2.307 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai PDO, Q6K, PDO, PDO Allosteric, Type1, Allosteric, Type1 696 - 1010 0 None None Epidermal growth factor receptor Homo sapiens

Ligand: PDO

Total number of chains: 1
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 1 100.0% 4L68A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
OTHER BIR2 BIR2_ARATH 4L68A 2.0 Pseudo DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiai APEdist_nioi PDO Allosteric 272 - 600 0 None None Inactive LRR receptor-like serine/threonine-protein kinase BIR2 Arabidopsis thaliana