Protein kinases in complex with AY7 (Asciminib)

Total number of genes: 1
Total number of chains: 3
Spatial Dihedral Chains Representative
DFGin BLBplus 2 8SSNA
DFGout None 1 5MO4A
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
TYR ABL1 ABL1_HUMAN Tyrosine-protein kinase ABL1 8SSNB 2.86 Inactive DFGin BLBplus out-out none-none AY7 SKI Allosteric Type1
TYR ABL1 ABL1_HUMAN Tyrosine-protein kinase ABL1 8SSNA 2.86 Inactive DFGin BLBplus out-out out-none AY7 SKI Allosteric Type1.5_Back
TYR ABL1 ABL1_HUMAN Tyrosine-protein kinase ABL1 5MO4A 2.17 Inactive DFGout None in-in none-out NIL AY7 Type2 Allosteric

Protein kinases in complex with AY7

Total number of genes: 1
Total number of chains: 3
Spatial Dihedral Chains Representative
DFGin BLBplus 2 8SSNA
DFGout None 1 5MO4A
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Homo sapiens TYR ABL1 ABL1_HUMAN Tyrosine-protein kinase ABL1 8SSNB 2.86 Inactive DFGin BLBplus out-out none-none AY7 SKI Allosteric Type1
Homo sapiens TYR ABL1 ABL1_HUMAN Tyrosine-protein kinase ABL1 8SSNA 2.86 Inactive DFGin BLBplus out-out out-none AY7 SKI Allosteric Type1.5_Back
Homo sapiens TYR ABL1 ABL1_HUMAN Tyrosine-protein kinase ABL1 5MO4A 2.17 Inactive DFGout None in-in none-out NIL AY7 Type2 Allosteric

Protein kinases in complex with AY7

Total number of genes: 0
Total number of chains: 0
Spatial Dihedral Chains Representative
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type