Ligand: AY7 (Asciminib)

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 2 66.7% 8SSNA
DFGout None 1 33.3% 5MO4A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
TYR ABL1 ABL1_HUMAN 8SSNB 2.86 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan AY7, SKI Allosteric, Type1 64 - 506 0 None None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 8SSNA 2.86 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nnnai APEdist_aaan AY7, SKI Allosteric, Type1.5_Back 64 - 507 0 None None Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 5MO4A 2.17 Inactive DFGout‑None in-in none-out TYR APEdihe_nnoai APEdist_aaao NIL, AY7 Type2, Allosteric 64 - 512 0 None None Tyrosine-protein kinase ABL1

Ligand: AY7 (Asciminib)

Total number of chains: 3
Active chains: 0
Total number of genes: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 2 66.7% 8SSNA
DFGout None 1 33.3% 5MO4A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
TYR ABL1 ABL1_HUMAN 8SSNB 2.86 Inactive DFGin‑BLBplus out-out none-none TYR APEdihe_nnnai APEdist_aaan AY7, SKI Allosteric, Type1 64 - 506 0 None None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 8SSNA 2.86 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nnnai APEdist_aaan AY7, SKI Allosteric, Type1.5_Back 64 - 507 0 None None Tyrosine-protein kinase ABL1 Homo sapiens
TYR ABL1 ABL1_HUMAN 5MO4A 2.17 Inactive DFGout‑None in-in none-out TYR APEdihe_nnoai APEdist_aaao NIL, AY7 Type2, Allosteric 64 - 512 0 None None Tyrosine-protein kinase ABL1 Homo sapiens

Ligand: AY7 (Asciminib)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism