Ligand: XIN (Nintedanib)

Total number of chains: 6
Active chains: 1
Total number of genes: 5
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 66.7% 5TE0A
DFGout BBAminus 1 16.7% 8S15A
DFGout None 1 16.7% 3C7QA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
CAMK MELK MELK_HUMAN 5MAFA 2.8 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn XIN Type1.5_Back 2 - 333 0 None None Maternal embryonic leucine zipper kinase
OTHER AAK1 AAK1_HUMAN 5TE0A 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii XIN Type1 27 - 345 0 None None AP2-associated protein kinase 1
TYR KDR VGFR2_HUMAN 3C7QA 2.1 Inactive DFGout‑None in-in none-out TYR APEdihe_iioai APEdist_aaao XIN Type1 819 - 1171 0 PTR1054,PTR1059 None Vascular endothelial growth factor receptor 2
TYR KIT KIT_HUMAN 8S15A 2.4 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai XIN Type1 554 - 929 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit
TYR RET RET_HUMAN 6NECA 1.87 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai XIN Type1.5_Back 713 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret
TYR RET RET_HUMAN 6NECC 1.87 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai XIN Type1.5_Back 705 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret

Ligand: XIN (Nintedanib)

Total number of chains: 6
Active chains: 1
Total number of genes: 5
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 66.7% 5TE0A
DFGout BBAminus 1 16.7% 8S15A
DFGout None 1 16.7% 3C7QA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CAMK MELK MELK_HUMAN 5MAFA 2.8 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn XIN Type1.5_Back 2 - 333 0 None None Maternal embryonic leucine zipper kinase Homo sapiens
OTHER AAK1 AAK1_HUMAN 5TE0A 1.9 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii XIN Type1 27 - 345 0 None None AP2-associated protein kinase 1 Homo sapiens
TYR KDR VGFR2_HUMAN 3C7QA 2.1 Inactive DFGout‑None in-in none-out TYR APEdihe_iioai APEdist_aaao XIN Type1 819 - 1171 0 PTR1054,PTR1059 None Vascular endothelial growth factor receptor 2 Homo sapiens
TYR KIT KIT_HUMAN 8S15A 2.4 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai XIN Type1 554 - 929 0 None I563S,V569S,Y609Q,L631S,M651E,I662H,D768H,R804N,V825D,C844S,L890S,H894Y,L912D,L923D Mast/stem cell growth factor receptor Kit Homo sapiens
TYR RET RET_HUMAN 6NECA 1.87 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai XIN Type1.5_Back 713 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens
TYR RET RET_HUMAN 6NECC 1.87 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai XIN Type1.5_Back 705 - 1012 0 None None Proto-oncogene tyrosine-protein kinase receptor Ret Homo sapiens

Ligand: XIN (Nintedanib)

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism