CSF1R (Macrophage colony-stimulating factor 1 receptor)

Group: TYR
Uniprot: CSF1R_HUMAN
Domain boundary: 582 - 912


Total number of chains: 23
Spatial Dihedral Chains Representative
DFGin BLAminus 2 AF-P07333-K1A
DFGout BBAminus 20 3BEAA
DFGout None 1 2OGVA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-P07333-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 574 - 920 None None 0
3LCDA 2.5 Active DFGin BLAminus in-in in-in BDY Type1 558 - 913 None None 2
8CGCA 1.925 Inactive DFGout BBAminus in-in out-in LMR UIK Allosteric Type1 547 - 919 None None 0
3BEAA 2.02 Inactive DFGout BBAminus in-in out-in IXH Type1 547 - 921 A933L None 0
2I1MA 1.8 Inactive DFGout BBAminus in-out out-in 5CN Type1 547 - 921 None None 0
8JOTA 1.69 Inactive DFGout BBAminus in-in out-in UKI Type1 543 - 914 C667T,C830S,C907T None 1
8W1LA 2.26 Inactive DFGout BBAminus in-in out-in A1AE3 Type1 563 - 914 None None 0
2I0VA 2.8 Inactive DFGout BBAminus in-in out-in 6C3 Type1 544 - 916 None None 1
2I0YA 1.9 Inactive DFGout BBAminus in-in out-in 5CN Type1 548 - 916 None None 1
3KRJA 2.1 Inactive DFGout BBAminus in-in out-in KRJ Type1 544 - 914 S686S None 1
3KRLA 2.4 Inactive DFGout BBAminus in-out out-in KRL Type1 545 - 912 S686S None 1
7TNHA 2.7 Inactive DFGout BBAminus in-none out-in I9W Type1 445 - 912 None None 0
6T2WA 1.7 Inactive DFGout BBAminus in-in out-in M9T Type1 547 - 916 None None 0
3DPKA 1.95 Inactive DFGout BBAminus in-in out-in 8C5 Type1.5_Back 548 - 912 None None 4
4HW7A 2.9 Inactive DFGout BBAminus in-in out-in 64M Type2 566 - 914 C667T,C830S,C907T None 0
4R7HA 2.8 Inactive DFGout BBAminus in-in out-in P31 Type2 544 - 915 C667T,C830S,C907T None 0
4R7IA 2.75 Inactive DFGout BBAminus in-in out-in STI Type2 567 - 914 C667T,C830S,C907T None 0
6N33A 2.25 Inactive DFGout BBAminus in-in out-in 622 Type2 566 - 915 C667T,C830S,C907T None 0
7MFCA 2.8 Inactive DFGout BBAminus in-none out-in Z6V Type2 567 - 913 C667T,C830S,C907T None 0
6WXJA 2.62 Inactive DFGout BBAminus in-in out-in UF4 Type2 559 - 917 None None 3
3LCOA 3.4 Inactive DFGout BBAminus in-in out-in LC0 Type2 551 - 915 None None 4
6IG8A 1.8 Inactive DFGout BBAminus in-in out-in A7O Type2 550 - 916 S688A None 0
2OGVA 2.7 Inactive DFGout None in-out out-in No_ligand No_ligand 543 - 918 None None 0

CSF1R (Macrophage colony-stimulating factor 1 receptor)

Group: TYR
Total number of chains: 23
Spatial Dihedral Chains Representative
DFGin BLAminus 2 AF-P07333-K1A
DFGout BBAminus 20 3BEAA
DFGout None 1 2OGVA
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens CSF1R_HUMAN AF-P07333-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 574 - 920 None None 0
Homo sapiens CSF1R_HUMAN 3LCDA 2.5 Active DFGin BLAminus in-in in-in BDY Type1 558 - 913 None None 2
Homo sapiens CSF1R_HUMAN 8CGCA 1.925 Inactive DFGout BBAminus in-in out-in LMR UIK Allosteric Type1 547 - 919 None None 0
Homo sapiens CSF1R_HUMAN 3BEAA 2.02 Inactive DFGout BBAminus in-in out-in IXH Type1 547 - 921 A933L None 0
Homo sapiens CSF1R_HUMAN 2I1MA 1.8 Inactive DFGout BBAminus in-out out-in 5CN Type1 547 - 921 None None 0
Homo sapiens CSF1R_HUMAN 8JOTA 1.69 Inactive DFGout BBAminus in-in out-in UKI Type1 543 - 914 C667T,C830S,C907T None 1
Homo sapiens CSF1R_HUMAN 8W1LA 2.26 Inactive DFGout BBAminus in-in out-in A1AE3 Type1 563 - 914 None None 0
Homo sapiens CSF1R_HUMAN 2I0VA 2.8 Inactive DFGout BBAminus in-in out-in 6C3 Type1 544 - 916 None None 1
Homo sapiens CSF1R_HUMAN 2I0YA 1.9 Inactive DFGout BBAminus in-in out-in 5CN Type1 548 - 916 None None 1
Homo sapiens CSF1R_HUMAN 3KRJA 2.1 Inactive DFGout BBAminus in-in out-in KRJ Type1 544 - 914 S686S None 1
Homo sapiens CSF1R_HUMAN 3KRLA 2.4 Inactive DFGout BBAminus in-out out-in KRL Type1 545 - 912 S686S None 1
Homo sapiens CSF1R_HUMAN 7TNHA 2.7 Inactive DFGout BBAminus in-none out-in I9W Type1 445 - 912 None None 0
Homo sapiens CSF1R_HUMAN 6T2WA 1.7 Inactive DFGout BBAminus in-in out-in M9T Type1 547 - 916 None None 0
Homo sapiens CSF1R_HUMAN 3DPKA 1.95 Inactive DFGout BBAminus in-in out-in 8C5 Type1.5_Back 548 - 912 None None 4
Homo sapiens CSF1R_HUMAN 4HW7A 2.9 Inactive DFGout BBAminus in-in out-in 64M Type2 566 - 914 C667T,C830S,C907T None 0
Homo sapiens CSF1R_HUMAN 4R7HA 2.8 Inactive DFGout BBAminus in-in out-in P31 Type2 544 - 915 C667T,C830S,C907T None 0
Homo sapiens CSF1R_HUMAN 4R7IA 2.75 Inactive DFGout BBAminus in-in out-in STI Type2 567 - 914 C667T,C830S,C907T None 0
Homo sapiens CSF1R_HUMAN 6N33A 2.25 Inactive DFGout BBAminus in-in out-in 622 Type2 566 - 915 C667T,C830S,C907T None 0
Homo sapiens CSF1R_HUMAN 7MFCA 2.8 Inactive DFGout BBAminus in-none out-in Z6V Type2 567 - 913 C667T,C830S,C907T None 0
Homo sapiens CSF1R_HUMAN 6WXJA 2.62 Inactive DFGout BBAminus in-in out-in UF4 Type2 559 - 917 None None 3
Homo sapiens CSF1R_HUMAN 3LCOA 3.4 Inactive DFGout BBAminus in-in out-in LC0 Type2 551 - 915 None None 4
Homo sapiens CSF1R_HUMAN 6IG8A 1.8 Inactive DFGout BBAminus in-in out-in A7O Type2 550 - 916 S688A None 0
Homo sapiens CSF1R_HUMAN 2OGVA 2.7 Inactive DFGout None in-out out-in No_ligand No_ligand 543 - 918 None None 0

CSF1R (Macrophage colony-stimulating factor 1 receptor)

No non-human structures known.