Ligand: ADP

Total number of chains: 206
Active chains: 71
Total number of genes: 47
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 161 78.2% 6YZHA
DFGin BLBplus 17 8.3% 4M15A
DFGin None 13 6.3% 4RIYD
DFGin ABAminus 5 2.4% 3LCTA
DFGinter None 4 1.9% 5L8LA
DFGin BLBminus 3 1.5% 8PR7D
None None 3 1.5% 2W5AA
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC CDC42BPB MRCKB_HUMAN 4UAKA Q9Y5S2 2 417 1711.0 ADP:60501 ATPlike Active DFGin 6.536 13.389 BLAminus -126.67, 169.91 71.43, 81.15 -99.11, 14.11 300.02, 102.96 -73.12, -5.53 in-in in 8.635 Saltbr-in 2.748 HRD-in -78.82, -49.28 69.95, 4.01 in-in-in SNCiii in-in ActLoopNT-in 2.977 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.28, 157.85 APE9-dihe-na 87.21, -164.86 APE8-dihe-in -127.15, 132.61 APE8-rot-in 302.21 APE67-dihe-in -64.23, -20.61 -57.86, -36.49 APE12-dist-in 10.511 APE11-dist-in 11.151 APE10-dist-in 6.313 APE9-dist-in 3.548 None None None XRAY 1.73 0.198 0.243 A 419 401 0 0 0 0 [[76, 342]] 1.0 4uak AGC_CDC42BPB_HUMAN AGC 6.5e-96 326.4 1 260 260 217 218 219 221 223 105 124 128 197 199 198 200 263 246 241 240 239 238 237 236 235 154 Serine/threonine-protein kinase MRCK beta
AGC PRKCI KPCI_HUMAN 5LIHA P41743 248 588 596.0 ADP:60601 ATPlike Active DFGin 5.403 11.863 BLAminus -129.58, 178.7 63.64, 84.98 -106.19, 67.5 320.36, 105.86 -96.86, -30.05 in-in in 9.178 Saltbr-in 3.031 HRD-in -49.42, -59.61 61.3, 24.72 in-in-in SNCiii in-in ActLoopNT-in 3.109 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.76, 169.43 APE9-dihe-na 122.35, -170.42 APE8-dihe-in -91.96, 136.55 APE8-rot-in 289.3 APE67-dihe-in -72.22, -23.04 -49.75, -40.52 APE12-dist-in 7.983 APE11-dist-in 10.986 APE10-dist-in 5.421 APE9-dist-in 3.56 None TPO412,TPO564 TPO412,TPO564 XRAY 3.25 0.258 0.284 A 349 326 15 0 0 0 [[254, 522]] 1.0 5lih AGC_PRKCI_HUMAN AGC 1.1e-95 325.5 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 5LIHB P41743 249 588 596.0 ADP:60601 ATPlike Active DFGin 5.31 11.876 BLAminus -129.18, 178.42 63.46, 84.62 -106.43, 67.35 320.63, 105.98 -96.29, -29.69 in-in in 8.72 Saltbr-in 2.545 HRD-in -49.62, -59.64 61.27, 24.64 in-in-in SNCiii in-in ActLoopNT-in 3.141 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.47, 168.99 APE9-dihe-na 122.16, -170.23 APE8-dihe-in -91.66, 136.86 APE8-rot-in 289.24 APE67-dihe-in -72.3, -22.91 -49.4, -40.32 APE12-dist-in 8.329 APE11-dist-in 11.256 APE10-dist-in 5.693 APE9-dist-in 3.742 None TPO412,TPO564 TPO412,TPO564 XRAY 3.25 0.258 0.284 B 349 320 20 0 0 0 [[254, 522]] 1.0 5lih AGC_PRKCI_HUMAN AGC 1.1e-95 325.5 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 9EJMB P41743 249 588 596.0 ADP:60601 ATPlike None DFGin 6.2 12.865 BLAminus -142.99, -166.55 58.77, 70.37 -95.2, 28.65 312.71, 127.0 -80.74, 2.56 in-none in 9.166 Saltbr-none 999.0 HRD-in -62.9, -53.16 64.41, -0.47 none-in-in SNCnii in-in ActLoopNT-in 3.152 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.58, 153.63 APE9-dihe-na 128.65, 169.74 APE8-dihe-in -69.25, 127.47 APE8-rot-in 310.74 APE67-dihe-in -76.65, -32.17 -60.48, -21.91 APE12-dist-in 9.603 APE11-dist-in 12.253 APE10-dist-in 6.595 APE9-dist-in 3.928 None TPO412,TPO564 TPO412,TPO564 EM 3.33 999.0 999.0 B 596 322 9 0 0 0 [[254, 522]] 1.0 9ejm AGC_PRKCI_HUMAN AGC 5.2e-95 323.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
CAMK AURKA AURKA_HUMAN 8GUWA O14965 506 388 403.0 ADP:60501 ATPlike Inactive DFGin 5.496 16.001 ABAminus -116.4, -50.49 -101.78, 116.28 -108.31, 28.43 281.67, 88.04 -72.88, -24.68 out-out out 11.779 Saltbr-out 6.963 HRD-out -52.32, 144.81 -137.03, 32.44 out-in-out SNCoio in-out ActLoopNT-in 2.989 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 154.24 APE8-dihe-in -135.99, 160.18 APE8-rot-out 182.57 APE67-dihe-in -45.22, -30.26 -102.15, -5.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 22.835 C290A,C393A None None XRAY 2.7 0.216 0.258 A 304 259 7 0 0 7 [[133, 383]] 1.0 8guw CAMK_AURKA_HUMAN CAMK 1.2e-78 270.0 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8GUWB O14965 507 390 403.0 ADP:60501 ATPlike Inactive DFGin 5.29 15.684 ABAminus -103.46, -56.86 -84.59, 164.71 -149.11, 43.73 280.55, 102.4 -37.77, -51.78 out-out out 11.222 Saltbr-out 10.124 HRD-out -88.2, 114.65 -57.32, -35.01 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 120.59 APE8-rot-out 188.97 APE67-dihe-out 79.95, -4.59 -68.08, -173.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C290A,C393A None None XRAY 2.7 0.216 0.258 B 304 250 13 0 0 13 [[133, 383]] 1.0 8guw CAMK_AURKA_HUMAN CAMK 1.2e-78 270.0 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8GUWC O14965 506 388 403.0 ADP:60501 ATPlike Inactive DFGin 5.794 16.123 ABAminus -112.39, -57.42 -66.39, 155.71 -143.31, 23.7 266.43, 102.44 -50.18, -24.58 out-out out 11.531 Saltbr-out 6.147 HRD-out -98.37, 113.81 -121.54, 28.92 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -46.16 APE8-rot-in 299.01 APE67-dihe-in -63.17, -8.64 -58.96, -54.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C290A,C393A None None XRAY 2.7 0.216 0.258 C 304 248 18 0 0 14 [[133, 383]] 1.0 8guw CAMK_AURKA_HUMAN CAMK 1.2e-78 270.0 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4BN1A O14965 126 388 403.0 ADP:1391 ATPlike Inactive DFGin 5.759 14.962 BLAminus -135.76, 176.64 57.4, 85.44 -97.06, 20.67 283.26, 70.95 -48.27, -40.43 in-in in 9.228 Saltbr-in 2.717 HRD-in -70.78, -55.66 70.88, -1.02 in-in-out SNCiio in-out ActLoopNT-in 2.8 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na 16.45, -154.0 APE9-dihe-na 66.92, -173.53 APE8-dihe-in -66.46, 155.86 APE8-rot-out 182.79 APE67-dihe-in -44.49, -32.18 -93.83, -6.12 APE12-dist-in 12.114 APE11-dist-in 8.731 APE10-dist-out 13.707 APE9-dist-out 11.159 V174M TPO287,TPO288 TPO287,TPO288 XRAY 2.499 0.195 0.244 A 285 263 0 0 0 0 [[133, 383]] 1.0 4bn1 CAMK_AURKA_HUMAN CAMK 7.5e-80 273.9 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 1MQ4A O14965 126 388 403.0 ADP:2001 ATPlike Inactive DFGin 5.607 15.213 BLAminus -132.59, 179.34 62.49, 72.25 -91.07, 21.51 279.91, 70.01 -61.32, -27.71 in-in in 9.055 Saltbr-in 2.88 HRD-in -82.66, -49.31 72.48, -1.39 in-in-out SNCiio in-out ActLoopNT-in 2.923 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -97.21, -164.83 APE9-dihe-na -146.02, -127.82 APE8-dihe-in -61.49, 131.42 APE8-rot-out 178.11 APE67-dihe-in -51.42, -34.84 -86.66, -6.25 APE12-dist-in 7.681 APE11-dist-in 11.847 APE10-dist-out 10.587 APE9-dist-out 9.978 None None None XRAY 1.9 0.229 0.273 A 272 261 2 0 0 2 [[133, 383]] 1.0 1mq4 CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 1OL5A O14965 123 388 403.0 ADP:1388 ATPlike Active DFGin 5.578 15.096 BLAminus -139.2, -172.08 52.22, 80.16 -90.83, 24.66 282.61, 72.55 -49.87, -44.18 in-in in 9.451 Saltbr-in 2.912 HRD-in -63.28, -60.88 73.6, 1.59 in-in-in SNCiii in-in ActLoopNT-in 2.928 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.42, 162.5 APE9-dihe-na 119.45, -153.19 APE8-dihe-in -110.77, 140.24 APE8-rot-in 313.06 APE67-dihe-in -62.23, -14.3 -43.16, -62.5 APE12-dist-in 8.174 APE11-dist-in 10.957 APE10-dist-in 5.274 APE9-dist-in 3.683 None TPO287,TPO288 TPO287,TPO288 XRAY 2.5 0.194 0.252 A 282 266 0 0 0 0 [[133, 383]] 1.0 1ol5 CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 1OL7A O14965 127 390 403.0 ADP:531 ATPlike Inactive DFGin 5.429 15.043 BLAminus -133.12, -167.56 48.98, 74.14 -88.94, 32.44 285.93, 64.91 -57.61, -36.14 in-in in 9.506 Saltbr-in 3.055 HRD-in -75.56, -48.34 63.05, 5.8 in-in-out SNCiio in-out ActLoopNT-in 2.978 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -104.11, 138.56 APE9-dihe-na 156.93, 143.05 APE8-dihe-in -89.37, 102.83 APE8-rot-out 182.11 APE67-dihe-in -15.17, -56.94 -45.24, -37.82 APE12-dist-in 11.267 APE11-dist-in 11.206 APE10-dist-out 10.465 APE9-dist-out 8.269 None TPO287,TPO288 TPO287,TPO288 XRAY 2.75 0.257 0.296 A 282 264 0 0 0 0 [[133, 383]] 1.0 1ol7 CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4DEEA O14965 124 394 403.0 ADP:503 ATPlike Inactive DFGin 5.977 15.579 BLAminus -131.54, -177.86 61.33, 72.14 -88.35, 17.45 278.56, 69.2 -56.76, -24.29 in-in in 9.236 Saltbr-in 2.836 HRD-in -80.53, -51.88 66.61, 1.43 in-in-out SNCiio in-out ActLoopNT-in 2.686 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -125.87, -53.37 APE9-dihe-na -86.66, -134.63 APE8-dihe-in -80.8, 152.73 APE8-rot-out 187.03 APE67-dihe-in -37.34, -40.8 -92.92, -9.81 APE12-dist-in 12.108 APE11-dist-in 10.787 APE10-dist-out 10.762 APE9-dist-out 10.532 T287D None None XRAY 2.3 0.213 0.259 A 279 271 0 0 0 0 [[133, 383]] 1.0 4dee CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5LXMA O14965 126 392 403.0 ADP:60501 ATPlike Active DFGin 5.391 14.976 BLAminus -135.45, -179.78 54.7, 80.97 -90.8, 30.12 283.16, 71.51 -72.4, -3.16 in-in in 9.247 Saltbr-in 2.724 HRD-in -74.23, -48.55 66.99, 5.01 in-in-in SNCiii in-in ActLoopNT-in 3.114 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.91, 137.37 APE9-dihe-na 128.62, -150.21 APE8-dihe-in -129.87, 142.81 APE8-rot-in 303.47 APE67-dihe-in -69.71, -10.62 -37.99, -61.07 APE12-dist-in 8.257 APE11-dist-in 10.692 APE10-dist-in 5.213 APE9-dist-in 3.298 C290A,C393A TPO288 TPO288 XRAY 2.08 0.202 0.243 A 283 267 0 0 0 0 [[133, 383]] 1.0 5lxm CAMK_AURKA_HUMAN CAMK 9.2e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4CEGA O14965 127 391 403.0 ADP:1392 ATPlike Inactive DFGin 6.321 15.665 BLAminus -126.79, -176.42 60.85, 65.85 -88.73, 20.26 276.07, 70.68 -62.71, -30.16 in-in in 8.907 Saltbr-in 2.752 HRD-in -80.9, -50.34 70.05, 0.74 in-in-out SNCiio in-out ActLoopNT-in 2.882 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -88.79, -42.25 APE9-dihe-na -103.79, -144.9 APE8-dihe-in -67.83, 148.92 APE8-rot-out 184.96 APE67-dihe-in -49.78, -34.34 -90.88, -2.74 APE12-dist-in 12.035 APE11-dist-in 10.991 APE10-dist-out 11.5 APE9-dist-out 10.933 C290A,C393A TPO288 TPO288 XRAY 2.1 0.202 0.237 A 285 265 0 0 0 0 [[133, 383]] 1.0 4ceg CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5G1XA O14965 126 389 403.0 ADP:1390 ATPlike Active DFGin 5.343 15.03 BLAminus -132.86, -170.57 52.68, 76.5 -90.96, 13.96 279.12, 78.43 -59.51, -20.51 in-in in 9.278 Saltbr-in 2.828 HRD-in -82.61, -50.12 70.7, 5.33 in-in-in SNCiii in-in ActLoopNT-in 2.963 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.42, -179.26 APE9-dihe-na 65.74, -155.89 APE8-dihe-in -128.23, 121.78 APE8-rot-in 304.75 APE67-dihe-in -61.27, -19.7 -46.07, -47.67 APE12-dist-in 8.247 APE11-dist-in 10.799 APE10-dist-in 5.53 APE9-dist-in 3.699 C290A,C393A TPO288 TPO288 XRAY 1.72 0.177 0.195 A 285 264 0 0 0 0 [[133, 383]] 1.0 5g1x CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORLA O14965 127 391 403.0 ADP:401,A4W:407 ATPlike,Allosteric Inactive DFGin 7.066 16.649 BLAminus -127.84, -172.28 56.81, 60.19 -82.35, 15.9 271.2, 75.61 -63.85, -28.67 in-in in 9.049 Saltbr-in 2.75 HRD-in -78.27, -48.5 74.34, -1.48 in-in-out SNCiio in-out ActLoopNT-in 2.977 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -99.11, -104.69 APE9-dihe-na -74.24, -110.44 APE8-dihe-in -76.15, 148.12 APE8-rot-out 189.45 APE67-dihe-in -56.74, -24.81 -85.95, -8.4 APE12-dist-in 12.072 APE11-dist-in 10.971 APE10-dist-out 10.388 APE9-dist-out 11.289 C290A TPO288 TPO288 XRAY 1.69 0.206 0.238 A 265 265 0 0 0 0 [[133, 383]] 1.0 5orl CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORNA O14965 127 391 403.0 ADP:401,A5E:404 ATPlike,Allosteric Inactive DFGin 5.672 15.403 BLAminus -130.34, -174.38 54.92, 79.97 -94.37, 17.54 279.26, 75.58 -55.07, -30.09 in-in in 9.354 Saltbr-in 2.929 HRD-in -81.32, -50.86 72.88, 0.4 in-in-out SNCiio in-out ActLoopNT-in 3.025 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -63.8, -59.63 APE9-dihe-na -97.49, -117.04 APE8-dihe-in -91.34, 143.03 APE8-rot-out 191.17 APE67-dihe-in -51.25, -26.05 -82.57, -15.54 APE12-dist-in 12.386 APE11-dist-in 10.402 APE10-dist-out 11.494 APE9-dist-out 11.357 None TPO288 TPO288 XRAY 2.19 0.203 0.262 A 265 265 0 0 0 0 [[133, 383]] 1.0 5orn CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OROA O14965 127 391 403.0 ADP:401,A5H:404 ATPlike,Allosteric Inactive DFGin 5.678 15.337 BLAminus -140.88, -178.26 60.46, 77.77 -94.07, 18.69 277.24, 76.82 -52.63, -39.97 in-in in 9.273 Saltbr-in 3.057 HRD-in -74.27, -52.41 74.24, -3.23 in-in-out SNCiio in-out ActLoopNT-in 2.843 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -87.43, -63.56 APE9-dihe-na -103.72, -111.07 APE8-dihe-in -78.78, 141.92 APE8-rot-out 181.93 APE67-dihe-in -53.21, -24.39 -89.75, -10.63 APE12-dist-in 12.176 APE11-dist-in 10.559 APE10-dist-out 11.001 APE9-dist-out 11.501 None TPO288 TPO288 XRAY 2.12 0.223 0.281 A 265 265 0 0 0 0 [[133, 383]] 1.0 5oro CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORPA O14965 127 391 403.0 ADP:401,A5K:404 ATPlike,Allosteric Inactive DFGin 5.812 15.492 BLAminus -139.84, -179.78 59.55, 79.52 -94.35, 18.72 278.85, 73.24 -45.22, -42.84 in-in in 9.387 Saltbr-in 2.908 HRD-in -83.1, -49.94 72.65, -1.94 in-in-out SNCiio in-out ActLoopNT-in 3.034 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -75.76, -64.68 APE9-dihe-na -107.0, -110.58 APE8-dihe-in -81.78, 136.28 APE8-rot-out 180.06 APE67-dihe-in -57.19, -28.31 -85.06, -6.26 APE12-dist-in 12.351 APE11-dist-in 10.944 APE10-dist-out 10.766 APE9-dist-out 11.367 None TPO288 TPO288 XRAY 2.19 0.21 0.273 A 265 265 0 0 0 0 [[133, 383]] 1.0 5orp CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORRA O14965 127 391 403.0 ADP:401,A5Q:404 ATPlike,Allosteric Inactive DFGin 5.665 15.497 BLAminus -133.78, -179.48 60.85, 73.72 -91.04, 29.58 281.03, 75.21 -67.99, -25.16 in-in in 9.421 Saltbr-in 3.055 HRD-in -80.95, -50.87 71.36, -2.01 in-in-out SNCiio in-out ActLoopNT-in 3.021 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -79.12, -78.89 APE9-dihe-na -94.43, -116.97 APE8-dihe-in -78.43, 147.39 APE8-rot-out 182.93 APE67-dihe-in -56.59, -23.94 -94.11, -3.91 APE12-dist-in 12.261 APE11-dist-in 11.02 APE10-dist-out 10.427 APE9-dist-out 11.066 None TPO288 TPO288 XRAY 2.09 0.202 0.256 A 265 265 0 0 0 0 [[133, 383]] 1.0 5orr CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORSA O14965 127 391 403.0 ADP:401,A5W:404 ATPlike,Allosteric Inactive DFGin 5.955 15.683 BLAminus -133.47, -175.79 56.95, 73.99 -92.77, 17.89 276.34, 75.78 -60.0, -24.97 in-in in 9.175 Saltbr-in 2.899 HRD-in -79.83, -50.16 70.98, -0.5 in-in-out SNCiio in-out ActLoopNT-in 3.002 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -90.64, -79.2 APE9-dihe-na -92.74, -115.85 APE8-dihe-in -81.19, 144.15 APE8-rot-out 184.83 APE67-dihe-in -58.67, -28.41 -85.39, -4.34 APE12-dist-in 12.193 APE11-dist-in 10.956 APE10-dist-out 10.626 APE9-dist-out 11.291 None TPO288 TPO288 XRAY 1.98 0.209 0.257 A 265 265 0 0 0 0 [[133, 383]] 1.0 5ors CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORTA O14965 127 391 403.0 ADP:401,A5Z:406 ATPlike,Allosteric Inactive DFGin 5.999 15.754 BLAminus -125.96, -170.73 54.43, 75.09 -90.85, 19.73 277.07, 68.86 -49.78, -34.73 in-in in 9.196 Saltbr-in 3.026 HRD-in -79.74, -50.38 68.95, 1.55 in-in-out SNCiio in-out ActLoopNT-in 3.084 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -85.06, -64.36 APE9-dihe-na -96.27, -115.21 APE8-dihe-in -89.65, 146.92 APE8-rot-out 194.22 APE67-dihe-in -52.62, -22.53 -93.73, -12.57 APE12-dist-in 12.531 APE11-dist-in 10.919 APE10-dist-out 10.824 APE9-dist-out 11.018 None TPO288 TPO288 XRAY 2.56 0.208 0.275 A 265 265 0 0 0 0 [[133, 383]] 1.0 5ort CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORVA O14965 127 391 403.0 ADP:401,A65:406 ATPlike,Allosteric Inactive DFGin 5.665 15.44 BLAminus -136.16, -176.05 58.92, 71.82 -89.03, 22.25 278.38, 76.78 -63.69, -25.31 in-in in 9.245 Saltbr-in 2.886 HRD-in -82.57, -52.35 73.38, 1.05 in-in-out SNCiio in-out ActLoopNT-in 3.006 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -75.39, -87.03 APE9-dihe-na -89.16, -112.46 APE8-dihe-in -77.62, 139.73 APE8-rot-out 181.74 APE67-dihe-in -57.59, -25.24 -84.67, -4.17 APE12-dist-in 12.313 APE11-dist-in 10.877 APE10-dist-out 10.421 APE9-dist-out 11.255 None TPO288 TPO288 XRAY 1.88 0.214 0.268 A 265 265 0 0 0 0 [[133, 383]] 1.0 5orv CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORWA O14965 127 391 403.0 ADP:401,A6E:404 ATPlike,Allosteric Inactive DFGin 5.706 15.413 BLAminus -131.01, -175.69 56.41, 78.46 -94.05, 21.38 277.67, 78.36 -59.98, -27.55 in-in in 9.316 Saltbr-in 3.005 HRD-in -84.25, -51.01 70.55, 2.29 in-in-out SNCiio in-out ActLoopNT-in 3.069 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -84.32, -59.08 APE9-dihe-na -102.85, -110.93 APE8-dihe-in -86.24, 134.05 APE8-rot-out 178.0 APE67-dihe-in -62.04, -25.17 -80.18, -4.89 APE12-dist-in 12.269 APE11-dist-in 10.81 APE10-dist-out 10.98 APE9-dist-out 11.2 None TPO288 TPO288 XRAY 2.0 0.217 0.27 A 265 265 0 0 0 0 [[133, 383]] 1.0 5orw CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORXA O14965 127 391 403.0 ADP:401,A6H:404 ATPlike,Allosteric Inactive DFGin 5.483 15.332 BLAminus -135.37, -175.69 58.5, 74.51 -88.48, 21.31 281.01, 74.45 -55.7, -31.23 in-in in 9.392 Saltbr-in 2.887 HRD-in -84.87, -52.92 73.65, 2.44 in-in-out SNCiio in-out ActLoopNT-in 2.957 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -81.41, -75.31 APE9-dihe-na -97.77, -112.93 APE8-dihe-in -77.56, 136.59 APE8-rot-out 185.81 APE67-dihe-in -60.3, -23.27 -81.45, -7.22 APE12-dist-in 12.271 APE11-dist-in 10.976 APE10-dist-out 10.248 APE9-dist-out 10.921 None TPO288 TPO288 XRAY 1.88 0.222 0.27 A 265 265 0 0 0 0 [[133, 383]] 1.0 5orx CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORYA O14965 127 391 403.0 ADP:401,AY4:406 ATPlike,Allosteric Inactive DFGin 5.665 15.432 BLAminus -133.35, -178.83 58.64, 81.27 -98.02, 26.99 280.05, 73.77 -66.34, -26.48 in-in in 9.413 Saltbr-in 3.015 HRD-in -83.1, -49.94 67.85, 0.8 in-in-out SNCiio in-out ActLoopNT-in 2.968 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -85.35, -78.87 APE9-dihe-na -90.27, -119.1 APE8-dihe-in -76.79, 146.69 APE8-rot-out 180.58 APE67-dihe-in -53.43, -25.94 -95.91, -5.0 APE12-dist-in 12.447 APE11-dist-in 11.047 APE10-dist-out 10.743 APE9-dist-out 11.153 None TPO288 TPO288 XRAY 1.99 0.207 0.265 A 265 265 0 0 0 0 [[133, 383]] 1.0 5ory CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORZA O14965 127 391 403.0 ADP:401,A6W:407 ATPlike,Allosteric Inactive DFGin 5.675 15.407 BLAminus -135.57, -175.22 57.46, 80.66 -98.54, 24.2 276.77, 79.7 -65.5, -21.43 in-in in 9.254 Saltbr-in 3.111 HRD-in -80.39, -48.42 71.09, -2.39 in-in-out SNCiio in-out ActLoopNT-in 3.062 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -82.59, -77.55 APE9-dihe-na -100.89, -113.21 APE8-dihe-in -76.47, 144.8 APE8-rot-out 177.65 APE67-dihe-in -57.19, -24.65 -94.21, -4.24 APE12-dist-in 12.301 APE11-dist-in 10.888 APE10-dist-out 10.402 APE9-dist-out 11.21 None TPO288 TPO288 XRAY 1.92 0.199 0.244 A 265 265 0 0 0 0 [[133, 383]] 1.0 5orz CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS0A O14965 127 391 403.0 ADP:401,A6Z:404 ATPlike,Allosteric Inactive DFGin 5.663 15.441 BLAminus -133.76, -174.78 57.78, 75.99 -91.75, 21.09 277.99, 75.39 -60.35, -28.95 in-in in 9.311 Saltbr-in 2.788 HRD-in -86.51, -49.56 71.53, 0.91 in-in-out SNCiio in-out ActLoopNT-in 2.96 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -90.57, -76.63 APE9-dihe-na -103.27, -112.09 APE8-dihe-in -75.93, 143.74 APE8-rot-out 179.33 APE67-dihe-in -59.48, -25.37 -86.69, -3.69 APE12-dist-in 12.156 APE11-dist-in 10.864 APE10-dist-out 10.257 APE9-dist-out 11.204 None TPO288 TPO288 XRAY 1.74 0.22 0.264 A 265 265 0 0 0 0 [[133, 383]] 1.0 5os0 CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS1A O14965 127 391 403.0 ADP:401,A7H:407 ATPlike,Allosteric Inactive DFGin 5.601 15.321 BLAminus -135.04, -179.66 61.87, 77.96 -95.19, 22.65 277.87, 73.62 -63.45, -26.73 in-in in 9.224 Saltbr-in 2.92 HRD-in -84.64, -47.57 66.67, 4.82 in-in-out SNCiio in-out ActLoopNT-in 3.016 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -71.95, -77.41 APE9-dihe-na -100.69, -116.41 APE8-dihe-in -72.42, 138.52 APE8-rot-out 177.77 APE67-dihe-in -60.13, -26.29 -83.6, -2.57 APE12-dist-in 12.239 APE11-dist-in 10.817 APE10-dist-out 10.599 APE9-dist-out 11.258 None TPO288 TPO288 XRAY 1.9 0.203 0.25 A 265 265 0 0 0 0 [[133, 383]] 1.0 5os1 CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS2A O14965 127 391 403.0 ADP:401,A7K:404 ATPlike,Allosteric Inactive DFGin 5.698 15.529 BLAminus -131.21, -175.25 58.7, 76.84 -90.56, 21.45 276.93, 76.69 -62.35, -9.35 in-in in 9.309 Saltbr-in 2.976 HRD-in -79.13, -51.53 72.78, 2.45 in-in-out SNCiio in-out ActLoopNT-in 3.018 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -27.53 APE9-dihe-na -109.52, -133.64 APE8-dihe-in -78.79, 129.87 APE8-rot-out 174.59 APE67-dihe-in -60.88, -25.02 -78.66, -3.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.83 APE9-dist-out 10.957 None None None XRAY 1.92 0.213 0.251 A 265 261 4 0 0 4 [[133, 383]] 1.0 5os2 CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS3A O14965 127 391 403.0 ADP:401,A7N:404 ATPlike,Allosteric Inactive DFGin 5.853 15.615 BLAminus -132.65, -178.67 63.71, 72.3 -91.21, 21.81 276.12, 75.45 -58.53, -29.86 in-in in 9.169 Saltbr-in 2.928 HRD-in -82.57, -48.69 69.82, -0.73 in-in-out SNCiio in-out ActLoopNT-in 2.966 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -97.05, -71.52 APE9-dihe-na -103.15, -115.69 APE8-dihe-in -76.83, 145.54 APE8-rot-out 186.8 APE67-dihe-in -55.71, -28.81 -87.14, -3.16 APE12-dist-in 12.183 APE11-dist-in 10.95 APE10-dist-out 10.376 APE9-dist-out 11.239 None TPO288 TPO288 XRAY 1.81 0.203 0.238 A 265 265 0 0 0 0 [[133, 383]] 1.0 5os3 CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS4A O14965 127 391 403.0 ADP:401,A8H:404 ATPlike,Allosteric Inactive DFGin 5.562 15.388 BLAminus -130.51, -177.66 61.48, 75.55 -91.39, 22.5 279.03, 76.09 -60.73, -28.57 in-in in 9.245 Saltbr-in 2.862 HRD-in -82.71, -48.02 68.35, 3.92 in-in-out SNCiio in-out ActLoopNT-in 2.959 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -77.92, -67.81 APE9-dihe-na -96.69, -121.48 APE8-dihe-in -75.57, 137.34 APE8-rot-out 180.49 APE67-dihe-in -57.86, -25.07 -81.82, -5.88 APE12-dist-in 12.257 APE11-dist-in 10.803 APE10-dist-out 10.935 APE9-dist-out 11.259 None TPO288 TPO288 XRAY 1.88 0.205 0.24 A 265 265 0 0 0 0 [[133, 383]] 1.0 5os4 CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS6A O14965 127 391 403.0 ADP:401,A7Q:404 ATPlike,Allosteric Inactive DFGin 6.029 15.781 BLAminus -126.13, -169.53 51.73, 76.81 -92.36, 19.58 272.42, 79.82 -57.78, -34.45 in-in in 9.245 Saltbr-in 2.995 HRD-in -81.41, -52.88 69.05, 4.37 in-in-out SNCiio in-out ActLoopNT-in 3.04 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -77.03, -70.53 APE9-dihe-na -90.32, -115.88 APE8-dihe-in -84.85, 141.6 APE8-rot-out 180.13 APE67-dihe-in -64.32, -26.41 -86.27, 0.74 APE12-dist-in 12.213 APE11-dist-in 10.826 APE10-dist-out 10.74 APE9-dist-out 10.992 None TPO288 TPO288 XRAY 2.2 0.216 0.277 A 265 265 0 0 0 0 [[133, 383]] 1.0 5os6 CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OSEA O14965 127 391 403.0 ADP:401,A98:404 ATPlike,Allosteric Inactive DFGin 5.646 15.441 BLAminus -134.11, -176.47 59.39, 78.15 -96.43, 21.72 274.12, 77.75 -65.33, -24.45 in-in in 9.137 Saltbr-in 2.885 HRD-in -78.93, -49.87 70.59, 0.35 in-in-out SNCiio in-out ActLoopNT-in 2.959 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -81.25, -72.54 APE9-dihe-na -105.09, -114.94 APE8-dihe-in -73.18, 141.65 APE8-rot-out 184.53 APE67-dihe-in -56.53, -26.26 -88.57, -5.48 APE12-dist-in 12.15 APE11-dist-in 10.976 APE10-dist-out 10.508 APE9-dist-out 11.253 None TPO288 TPO288 XRAY 1.9 0.192 0.237 A 265 265 0 0 0 0 [[133, 383]] 1.0 5ose CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OSFA O14965 127 391 403.0 ADP:401,A9E:404 ATPlike,Allosteric Inactive DFGin 5.759 15.656 BLAminus -131.88, -178.74 65.35, 71.33 -84.84, 21.28 278.92, 73.36 -65.0, -27.04 in-in in 9.314 Saltbr-in 2.827 HRD-in -85.08, -46.49 62.7, 8.17 in-in-out SNCiio in-out ActLoopNT-in 2.965 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -87.68, -61.8 APE9-dihe-na -106.59, -110.06 APE8-dihe-in -85.81, 135.3 APE8-rot-out 180.39 APE67-dihe-in -56.65, -25.75 -79.56, -7.54 APE12-dist-in 12.204 APE11-dist-in 10.69 APE10-dist-out 10.913 APE9-dist-out 11.453 None TPO288 TPO288 XRAY 1.89 0.204 0.254 A 265 265 0 0 0 0 [[133, 383]] 1.0 5osf CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OSDA O14965 125 391 403.0 ADP:401,A9B:404 ATPlike,Allosteric Inactive DFGin 5.672 15.444 BLAminus -133.73, -178.01 59.76, 77.67 -95.6, 25.32 277.59, 73.38 -66.16, -23.93 in-in in 9.153 Saltbr-in 2.914 HRD-in -79.03, -50.3 71.01, -1.56 in-in-out SNCiio in-out ActLoopNT-in 3.037 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -81.55, -62.64 APE9-dihe-na -107.55, -120.42 APE8-dihe-in -75.26, 143.45 APE8-rot-out 177.88 APE67-dihe-in -54.13, -27.04 -91.57, -4.8 APE12-dist-in 12.25 APE11-dist-in 11.074 APE10-dist-out 10.806 APE9-dist-out 11.197 None TPO288 TPO288 XRAY 1.99 0.198 0.239 A 267 267 0 0 0 0 [[133, 383]] 1.0 5osd CAMK_AURKA_HUMAN CAMK 7.4e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS5A O14965 125 392 403.0 ADP:401,A8K:404 ATPlike,Allosteric Inactive DFGin 5.536 15.275 BLAminus -135.35, -174.05 58.1, 79.63 -93.47, 22.72 276.13, 73.04 -64.31, -25.3 in-in in 9.38 Saltbr-in 2.868 HRD-in -80.2, -52.69 73.71, 2.64 in-in-out SNCiio in-out ActLoopNT-in 2.88 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -96.33, -47.43 APE9-dihe-na -104.6, -130.88 APE8-dihe-in -73.88, 139.12 APE8-rot-out 187.09 APE67-dihe-in -61.32, -25.92 -83.14, -4.09 APE12-dist-in 12.281 APE11-dist-in 10.845 APE10-dist-out 11.357 APE9-dist-out 10.954 None TPO288 TPO288 XRAY 1.74 0.199 0.236 A 268 268 0 0 0 0 [[133, 383]] 1.0 5os5 CAMK_AURKA_HUMAN CAMK 7.5e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6R49A O14965 127 391 403.0 ADP:501,JSB:504 ATPlike,Allosteric Inactive DFGin 5.614 15.457 BLAminus -138.43, -175.42 57.6, 78.22 -94.44, 21.89 276.25, 76.24 -57.77, -33.65 in-in in 9.381 Saltbr-in 2.894 HRD-in -87.16, -51.58 76.44, -3.34 in-in-out SNCiio in-out ActLoopNT-in 3.102 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -122.85 APE8-dihe-in -81.14, 140.15 APE8-rot-out 187.07 APE67-dihe-in -51.76, -30.76 -84.84, -7.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.053 C290A,C393A TPO288 TPO288 XRAY 2.209 0.194 0.24 A 285 260 5 0 0 5 [[133, 383]] 1.0 6r49 CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6R4AA O14965 127 391 403.0 ADP:501,JRT:510 ATPlike,Allosteric Inactive DFGin 6.157 15.949 BLAminus -128.43, -176.18 59.16, 64.31 -84.29, 19.22 274.78, 74.05 -63.59, -28.66 in-in in 9.102 Saltbr-in 2.825 HRD-in -85.32, -47.41 69.85, -3.89 in-in-out SNCiio in-out ActLoopNT-in 3.023 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -103.23, -102.89 APE9-dihe-na -87.4, -108.97 APE8-dihe-in -74.29, 145.29 APE8-rot-out 184.87 APE67-dihe-in -57.97, -25.59 -89.08, -1.69 APE12-dist-in 12.109 APE11-dist-in 10.868 APE10-dist-out 9.943 APE9-dist-out 11.448 C290A,C393A TPO288 TPO288 XRAY 1.937 0.193 0.234 A 285 265 0 0 0 0 [[133, 383]] 1.0 6r4a CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6R4BA O14965 127 391 403.0 ADP:501,JSN:508 ATPlike,Allosteric Inactive DFGin 5.894 15.663 BLAminus -137.57, -177.62 60.57, 72.93 -89.1, 20.04 274.87, 75.15 -57.71, -33.47 in-in in 9.285 Saltbr-in 2.891 HRD-in -83.52, -48.93 71.64, -3.16 in-in-out SNCiio in-out ActLoopNT-in 2.96 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -86.33, -81.37 APE9-dihe-na -105.19, -110.27 APE8-dihe-in -73.56, 134.57 APE8-rot-out 182.29 APE67-dihe-in -52.75, -29.28 -80.52, -6.55 APE12-dist-in 12.186 APE11-dist-in 10.955 APE10-dist-out 10.156 APE9-dist-out 11.376 None TPO288 TPO288 XRAY 2.15 0.191 0.23 A 285 265 0 0 0 0 [[133, 383]] 1.0 6r4b CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6R4CA O14965 127 391 403.0 ADP:501,JRQ:507 ATPlike,Allosteric Inactive DFGin 6.021 15.666 BLAminus -134.91, -179.34 60.98, 67.5 -85.83, 17.59 275.41, 71.94 -60.31, -30.9 in-in in 9.068 Saltbr-in 2.769 HRD-in -80.73, -51.78 76.01, -7.95 in-in-out SNCiio in-out ActLoopNT-in 2.891 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -93.37, -96.1 APE9-dihe-na -98.19, -111.55 APE8-dihe-in -67.65, 142.09 APE8-rot-out 185.03 APE67-dihe-in -56.49, -28.95 -89.55, -1.14 APE12-dist-in 12.192 APE11-dist-in 10.889 APE10-dist-out 9.931 APE9-dist-out 11.395 C290A,C393A TPO288 TPO288 XRAY 2.04 0.188 0.226 A 285 265 0 0 0 0 [[133, 383]] 1.0 6r4c CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6R4DA O14965 127 391 403.0 ADP:501,JRW:505 ATPlike,Allosteric Inactive DFGin 5.413 15.061 BLAminus -136.32, -175.95 60.26, 82.3 -97.39, 21.73 280.16, 71.96 -61.32, -30.02 in-in in 9.377 Saltbr-in 2.936 HRD-in -84.35, -49.77 70.9, 2.54 in-in-out SNCiio in-out ActLoopNT-in 2.898 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -109.88, -49.72 APE9-dihe-na -75.41, -134.11 APE8-dihe-in -89.35, 144.76 APE8-rot-out 181.5 APE67-dihe-in -55.31, -28.98 -80.38, -7.16 APE12-dist-in 12.169 APE11-dist-in 10.39 APE10-dist-out 11.478 APE9-dist-out 10.589 C290A,C393A TPO288 TPO288 XRAY 2.009 0.197 0.233 A 285 265 0 0 0 0 [[133, 383]] 1.0 6r4d CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 7ZTLA O14965 126 389 403.0 ADP:501,BCN:506 ATPlike,Allosteric Active DFGin 5.623 15.108 BLAminus -131.55, 179.55 58.91, 75.38 -87.97, 22.52 281.42, 69.29 -65.3, -21.25 in-in in 9.225 Saltbr-in 2.815 HRD-in -81.87, -52.88 75.2, 3.05 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.79, 177.44 APE9-dihe-na 70.08, -157.96 APE8-dihe-in -126.05, 125.84 APE8-rot-in 309.73 APE67-dihe-in -58.88, -23.16 -51.84, -48.56 APE12-dist-in 8.126 APE11-dist-in 10.601 APE10-dist-in 5.354 APE9-dist-in 3.765 C290A,K339C,C393A TPO288 TPO288 XRAY 1.9 0.165 0.193 A 309 264 0 0 0 0 [[133, 383]] 1.0 7ztl CAMK_AURKA_HUMAN CAMK 4.2e-78 268.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8OF5A O14965 126 390 403.0 ADP:501,MPO:505 ATPlike,Allosteric Inactive DFGin 5.561 15.073 BLAminus -147.6, 177.58 63.9, 71.93 -82.69, 26.74 280.62, 72.05 -50.28, -40.53 in-in in 9.376 Saltbr-in 2.739 HRD-in -82.42, -53.84 70.6, 7.86 in-in-out SNCiio in-out ActLoopNT-in 2.987 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na 65.3, 47.54 APE9-dihe-na -68.67, -176.82 APE8-dihe-in -69.15, 145.4 APE8-rot-out 54.1 APE67-dihe-in -51.26, -26.94 -88.64, -16.45 APE12-dist-out 18.239 APE11-dist-out 20.587 APE10-dist-out 23.612 APE9-dist-out 27.905 C290A,N332A,Q335A,C393A None None XRAY 1.97 0.186 0.235 A 285 265 0 0 0 0 [[133, 383]] 1.0 8of5 CAMK_AURKA_HUMAN CAMK 3.1e-78 268.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C14A O14965 126 389 403.0 ADP:417,T5L:418,T0L:424 ATPlike,Allosteric,Allosteric Inactive DFGin 5.631 14.794 BLAminus -132.92, -178.64 59.29, 78.11 -87.91, 19.69 280.37, 75.08 -49.0, -40.94 in-in in 9.323 Saltbr-in 2.749 HRD-in -74.47, -52.26 68.72, 1.37 in-in-out SNCiio in-out ActLoopNT-in 2.823 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -125.05, 2.89 APE9-dihe-na -76.04, 173.54 APE8-dihe-in -47.98, 133.45 APE8-rot-in 311.24 APE67-dihe-in -48.21, -32.08 -100.5, -9.07 APE12-dist-in 9.082 APE11-dist-in 13.03 APE10-dist-out 15.593 APE9-dist-out 10.893 None TPO288 TPO288 XRAY 1.93 0.182 0.194 A 272 264 0 0 0 0 [[133, 383]] 1.0 8c14 CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C15A O14965 126 388 403.0 ADP:401,T4C:404,T5L:405 ATPlike,Allosteric,Allosteric Inactive DFGin 5.658 14.941 BLAminus -128.39, 176.76 57.21, 80.94 -90.54, 19.4 280.16, 77.64 -46.89, -42.14 in-in in 9.356 Saltbr-in 2.912 HRD-in -70.87, -48.88 65.09, -5.38 in-in-out SNCiio in-out ActLoopNT-in 2.848 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -170.75 APE8-dihe-in -66.3, 161.07 APE8-rot-out 73.39 APE67-dihe-in -37.43, -35.12 -85.37, -6.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.144 C290A None None XRAY 2.41 0.199 0.207 A 265 259 4 0 0 4 [[133, 383]] 1.0 8c15 CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1FA O14965 126 388 403.0 ADP:401,T5L:409,T2O:417 ATPlike,Allosteric,Allosteric Inactive DFGin 5.472 14.634 BLAminus -130.51, -175.69 56.68, 77.24 -89.7, 19.52 279.6, 79.65 -52.03, -32.93 in-in in 9.302 Saltbr-in 2.811 HRD-in -73.98, -48.91 69.8, -1.54 in-in-out SNCiio in-out ActLoopNT-in 2.877 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -138.04 APE8-dihe-in -67.54, 164.12 APE8-rot-out 77.8 APE67-dihe-in -44.07, -35.33 -85.42, 0.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.522 C290A None None XRAY 1.924 0.206 0.234 A 265 258 5 0 0 5 [[133, 383]] 1.0 8c1f CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1IA O14965 126 388 403.0 ADP:401,T1L:404,T5L:405 ATPlike,Allosteric,Allosteric Inactive DFGin 5.524 14.838 BLAminus -129.39, -179.52 57.08, 78.15 -89.88, 20.87 280.11, 76.95 -51.9, -37.66 in-in in 9.355 Saltbr-in 2.906 HRD-in -72.05, -49.31 67.09, -4.7 in-in-out SNCiio in-out ActLoopNT-in 2.821 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -172.24 APE8-dihe-in -59.73, 161.33 APE8-rot-out 79.24 APE67-dihe-in -39.82, -36.32 -87.05, -1.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.341 C290A None None XRAY 2.81 0.213 0.234 A 265 260 3 0 0 3 [[133, 383]] 1.0 8c1i CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1MA O14965 127 389 403.0 T4X:402,ADP:404 Allosteric,ATPlike Inactive DFGin 5.6 15.272 BLAminus -122.0, 174.82 64.71, 68.72 -82.42, 30.82 279.23, 73.39 -59.87, -38.7 in-in in 9.647 Saltbr-in 3.053 HRD-in -66.75, -51.37 63.02, 9.93 in-in-out SNCiio in-out ActLoopNT-in 2.895 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -144.61, 52.2 APE9-dihe-na -98.47, -158.53 APE8-dihe-in -77.97, 114.41 APE8-rot-out 83.32 APE67-dihe-in -36.94, -36.23 -77.28, -23.95 APE12-dist-in 9.528 APE11-dist-in 12.989 APE10-dist-out 15.755 APE9-dist-out 10.619 None TPO288 TPO288 XRAY 2.84 0.253 0.269 A 273 263 0 0 0 0 [[133, 383]] 1.0 8c1m CAMK_AURKA_HUMAN CAMK 6.5e-80 274.0 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1DA O14965 127 388 403.0 T2F:401,ADP:402,T5L:405 Allosteric,ATPlike,Allosteric Inactive DFGin 5.59 14.77 BLAminus -129.39, 179.64 57.3, 80.97 -92.88, 23.53 280.13, 79.47 -56.16, -33.44 in-in in 9.306 Saltbr-in 2.936 HRD-in -72.1, -50.49 67.69, -1.24 in-in-out SNCiio in-out ActLoopNT-in 2.796 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 144.85 APE8-dihe-in -64.26, 154.27 APE8-rot-out 88.6 APE67-dihe-in -39.49, -36.75 -82.32, -6.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.088 C290A None None XRAY 2.115 0.212 0.238 A 265 259 3 0 0 3 [[133, 383]] 1.0 8c1d CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1GA O14965 127 388 403.0 T3I:401,ADP:402,T5L:406 Allosteric,ATPlike,Allosteric Inactive DFGin 5.544 14.882 BLAminus -128.11, -179.39 58.87, 76.11 -85.79, 22.41 279.68, 78.85 -51.87, -42.67 in-in in 9.223 Saltbr-in 2.92 HRD-in -78.13, -46.93 64.28, -1.01 in-in-out SNCiio in-out ActLoopNT-in 2.859 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -158.88 APE8-dihe-in -70.7, 159.97 APE8-rot-out 74.34 APE67-dihe-in -36.07, -37.71 -84.84, -3.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.355 C290A None None XRAY 1.96 0.2 0.225 A 265 258 4 0 0 4 [[133, 383]] 1.0 8c1g CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1HA O14965 127 388 403.0 T3U:401,ADP:402,T5L:405 Allosteric,ATPlike,Allosteric Inactive DFGin 5.603 14.806 BLAminus -133.2, 171.3 67.89, 80.13 -90.96, 20.95 279.09, 80.15 -47.86, -43.49 in-in in 9.274 Saltbr-in 3.002 HRD-in -69.34, -50.65 67.03, -6.54 in-in-out SNCiio in-out ActLoopNT-in 2.865 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -157.54 APE8-dihe-in -70.83, 158.42 APE8-rot-out 74.14 APE67-dihe-in -36.91, -39.82 -81.98, -5.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.528 C290A None None XRAY 2.233 0.213 0.245 A 265 258 4 0 0 4 [[133, 383]] 1.0 8c1h CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1KA O14965 127 388 403.0 T4O:401,ADP:402,T5L:405 Allosteric,ATPlike,Allosteric Inactive DFGin 5.397 14.797 BLAminus -136.92, -175.3 58.28, 79.92 -93.28, 13.0 269.57, 89.35 -50.4, -38.71 in-in in 9.603 Saltbr-in 3.114 HRD-in -64.38, -56.58 69.39, -9.24 in-in-out SNCiio in-out ActLoopNT-in 3.009 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na 39.31, -114.48 APE9-dihe-na 117.85, -67.49 APE8-dihe-in -136.08, 128.66 APE8-rot-out 19.12 APE67-dihe-in -37.03, -29.23 -73.31, -14.52 APE12-dist-in 9.258 APE11-dist-in 12.914 APE10-dist-out 12.688 APE9-dist-out 10.835 C290A None None XRAY 2.43 0.219 0.242 A 273 262 0 0 0 0 [[133, 383]] 1.0 8c1k CAMK_AURKA_HUMAN CAMK 8e-79 270.5 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8PR7D O14965 126 388 403.0 ADP:501 ATPlike Inactive DFGin 6.916 17.682 BLBminus -119.47, -172.43 57.55, 67.82 -98.5, 138.77 288.48, 69.88 152.2, -37.73 out-none out 11.781 Saltbr-none 999.0 HRD-in -89.57, -45.69 63.63, 4.27 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, 178.01 APE9-dihe-na 51.17, 13.86 APE8-dihe-out -88.74, -9.17 APE8-rot-none 999.0 APE67-dihe-in -65.89, -30.04 -136.83, 2.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.929 APE9-dist-out 11.396 D274N,C290A,N332A,Q335A,T347A,D350A,C393A None None XRAY 2.76 0.205 0.256 D 283 251 12 0 0 12 [[133, 383]] 1.0 8pr7 CAMK_AURKA_HUMAN CAMK 3e-77 265.4 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ODTA O14965 126 392 403.0 ADP:501 ATPlike Inactive DFGin 6.717 16.96 None -121.13, 4.47 -111.78, 32.81 -79.52, 164.76 286.94, 96.78 78.48, -128.28 out-out out 11.748 Saltbr-out 10.767 HRD-out -137.93, 83.59 -73.55, -34.72 out-out-out SNCooo out-out ActLoopNT-out 17.788 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, -15.28 APE9-dihe-na -98.55, 177.35 APE8-dihe-out 65.78, -46.63 APE8-rot-none 999.0 APE67-dihe-in -47.55, -29.4 -45.89, -32.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 24.867 APE9-dist-out 13.437 D274N,C290A,C393A None None XRAY 2.021 0.179 0.211 A 283 258 9 0 0 9 [[133, 383]] 1.0 5odt CAMK_AURKA_HUMAN CAMK 5.4e-78 267.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 9GUCA O14965 124 391 403.0 ADP:501,AMP:503 ATPlike,Allosteric Inactive DFGin 7.177 17.543 None -98.47, -53.8 -99.76, 123.69 -123.57, 999.0 272.41, 116.36 999.0, 999.0 out-none out 10.881 Saltbr-none 999.0 HRD-in -77.17, -58.19 77.29, 1.39 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na -78.2, -27.21 APE9-dihe-na 141.47, -167.5 APE8-dihe-in -95.93, 123.55 APE8-rot-in 299.51 APE67-dihe-in -57.72, -20.14 -51.84, -47.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.708 C290A,C393A None None XRAY 2.1 0.193 0.232 A 285 256 12 0 0 12 [[133, 383]] 1.0 9guc CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5L8JA O14965 126 391 403.0 ADP:60501 ATPlike Inactive DFGinter 6.039 8.812 None -121.42, -0.81 -92.81, -3.45 60.99, 19.44 297.14, 26.84 -77.84, 60.22 out-out out 13.201 Saltbr-out 9.588 HRD-out -100.39, 154.9 -77.66, -154.82 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 16.48 APE8-rot-out 62.75 APE67-dihe-in -57.65, -20.32 -54.21, -40.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C290A,C393A TPO288 TPO288 XRAY 1.68 0.201 0.231 A 285 253 13 0 0 13 [[133, 383]] 1.0 5l8j CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5L8KA O14965 126 392 403.0 ADP:60501 ATPlike Inactive DFGinter 5.934 8.696 None -123.53, 3.87 -94.88, 4.13 51.12, 25.43 307.6, 8.65 -83.23, 69.32 out-out out 12.906 Saltbr-out 9.137 HRD-out -94.24, 154.96 -82.75, -161.39 out-out-out SNCooo out-out ActLoopNT-out 5.262 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -60.54, 152.13 APE9-dihe-na 121.57, -104.82 APE8-dihe-in -138.45, 120.03 APE8-rot-in 300.38 APE67-dihe-in -56.47, -22.96 -75.46, -21.38 APE12-dist-out 14.19 APE11-dist-out 17.885 APE10-dist-out 19.722 APE9-dist-out 13.729 C290A,C393A TPO288 TPO288 XRAY 1.79 0.192 0.235 A 285 267 0 0 0 0 [[133, 383]] 1.0 5l8k CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5L8LA O14965 126 389 403.0 ADP:60501 ATPlike Inactive DFGinter 5.647 8.882 None -117.8, 6.57 -92.89, -1.12 53.22, 20.44 289.58, 36.26 -84.0, 68.46 out-out out 12.54 Saltbr-out 9.027 HRD-out -99.09, 148.91 -94.35, -164.8 out-out-out SNCooo out-out ActLoopNT-out 5.393 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -75.26, -165.41 APE9-dihe-na -67.89, -63.26 APE8-dihe-out -124.39, -179.64 APE8-rot-out 64.28 APE67-dihe-in -57.8, -26.84 -83.02, -0.31 APE12-dist-in 11.109 APE11-dist-out 16.52 APE10-dist-out 14.491 APE9-dist-out 14.639 C290A,C393A TPO288 TPO288 XRAY 1.67 0.193 0.223 A 285 264 0 0 0 0 [[133, 383]] 1.0 5l8l CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8PR7A O14965 124 389 403.0 ADP:501 ATPlike Inactive DFGinter 5.07 10.273 None -105.95, 148.75 -124.79, 28.7 -129.06, 999.0 303.51, 120.23 999.0, 999.0 out-out out 12.482 Saltbr-out 11.706 HRD-out 52.78, 71.6 -97.43, 142.22 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 47.95, -115.05 APE9-dihe-na -125.01, 9.37 APE8-dihe-out -40.29, -50.01 APE8-rot-out 85.86 APE67-dihe-in -55.11, -34.07 -62.49, -38.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.832 D274N,C290A,N332A,Q335A,T347A,D350A,C393A None None XRAY 2.76 0.205 0.256 A 283 253 13 0 0 13 [[133, 383]] 1.0 8pr7 CAMK_AURKA_HUMAN CAMK 3e-77 265.4 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2WQEA O14965 127 388 403.0 ADP:1389,ADP:1390,ADP:1391 ATPlike,ATPlike,ATPlike Inactive None 999.0 999.0 None -107.12, -44.35 28.24, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 12.428 Saltbr-none 999.0 HRD-out -82.99, 160.23 -97.32, -44.1 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -56.47 APE8-dihe-out -79.62, -22.51 APE8-rot-in 267.0 APE67-dihe-in -40.62, -26.16 -46.48, -55.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.796 S155R None None XRAY 2.5 0.206 0.251 A 262 241 21 0 0 16 [[133, 383]] 1.0 2wqe CAMK_AURKA_HUMAN CAMK 9.7e-80 273.5 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK CAMK2A KCC2A_HUMAN 7UJSA Q9UQM7 7 274 478.0 ADP:301 ATPlike Active DFGin 6.209 15.164 BLAminus -142.86, -173.92 52.2, 80.06 -100.62, 24.47 291.74, 81.6 -63.11, -26.23 in-in in 9.512 Saltbr-in 3.444 HRD-in -76.47, -52.69 80.52, -7.0 in-in-in SNCiii in-in ActLoopNT-in 2.952 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.88, 140.41 APE9-dihe-na 133.49, -148.09 APE8-dihe-in -128.43, 117.33 APE8-rot-in 305.05 APE67-dihe-in -59.07, -26.67 -36.29, -54.08 APE12-dist-in 10.197 APE11-dist-in 11.505 APE10-dist-in 5.779 APE9-dist-in 3.683 Q223K None None XRAY 2.75 0.201 0.262 A 268 268 0 0 0 0 [[13, 271]] 1.0 7ujs CAMK_CAMK2A_HUMAN CAMK 1e-96 329.1 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 7UJPA Q9UQM7 7 274 478.0 ADP:301 ATPlike Active DFGin 6.775 14.64 BLAminus -129.88, 174.11 65.35, 73.67 -96.28, 29.41 284.7, 81.79 -65.3, -26.47 in-in in 8.527 Saltbr-in 2.903 HRD-in -76.38, -51.72 77.74, -11.0 in-in-in SNCiii in-in ActLoopNT-in 2.875 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.94, 142.69 APE9-dihe-na 139.08, -169.53 APE8-dihe-in -115.65, 123.25 APE8-rot-in 308.77 APE67-dihe-in -69.44, -15.11 -33.38, -56.34 APE12-dist-in 10.469 APE11-dist-in 11.397 APE10-dist-in 5.657 APE9-dist-in 3.521 D135N,Q223K None None XRAY 2.56 0.234 0.281 A 268 268 0 0 0 0 [[13, 271]] 1.0 7ujp CAMK_CAMK2A_HUMAN CAMK 9.3e-96 326.0 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CHEK2 CHK2_HUMAN 2CN5A O96017 209 504 543.0 ADP:61509 ATPlike Inactive DFGin 6.789 14.494 BLAminus -135.2, 179.16 64.2, 79.37 -102.1, 20.75 283.06, 77.6 -58.46, -25.36 in-out in 9.917 Saltbr-out 4.344 HRD-in -79.96, -48.23 69.59, 1.14 out-in-out SNCoio in-out ActLoopNT-in 2.848 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -76.74, 7.44 APE9-dihe-na -76.93, 179.76 APE8-dihe-out 76.66, 47.76 APE8-rot-out 216.78 APE67-dihe-in -44.78, -36.74 -82.05, -7.37 APE12-dist-out 25.363 APE11-dist-out 27.519 APE10-dist-out 29.872 APE9-dist-out 32.768 None None None XRAY 2.25 0.201 0.24 A 329 282 14 0 0 0 [[220, 486]] 1.0 2cn5 CAMK_CHEK2_HUMAN CAMK 2.1e-85 292.1 1 256 256 367 368 369 371 373 249 273 277 344 346 345 347 409 394 389 388 387 386 385 384 383 302 Serine/threonine-protein kinase Chk2
CAMK DAPK1 DAPK1_HUMAN 2W4JA P53355 2 277 1430.0 ADP:1278 ATPlike Inactive DFGin 6.586 13.895 BLAminus -123.3, -175.29 63.17, 81.91 -95.29, 20.87 287.95, 79.94 -69.92, -15.2 in-in in 8.992 Saltbr-in 2.745 HRD-in -74.79, -47.39 66.71, 11.49 in-in-out SNCiio in-out ActLoopNT-in 2.931 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -155.28, 112.88 APE9-dihe-na -96.93, -134.15 APE8-dihe-in -90.19, 126.44 APE8-rot-in 297.68 APE67-dihe-in -65.36, -18.9 -46.88, -44.63 APE12-dist-in 10.357 APE11-dist-out 6.539 APE10-dist-out 9.665 APE9-dist-in 4.992 None None None XRAY 1.3 0.132 0.159 A 277 276 0 0 0 0 [[13, 275]] 1.0 2w4j CAMK_DAPK1_HUMAN CAMK 4.9e-95 323.6 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3EH9A P53355 2 277 1430.0 ADP:60001 ATPlike Inactive DFGin 6.72 14.106 BLAminus -121.08, 178.11 65.97, 83.53 -97.47, 22.9 284.12, 79.86 -68.8, -21.44 in-in in 9.515 Saltbr-in 3.088 HRD-in -77.18, -44.06 68.03, 9.36 in-in-out SNCiio in-out ActLoopNT-in 2.899 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -93.65, 114.44 APE9-dihe-na -90.95, -143.91 APE8-dihe-in -83.41, 125.11 APE8-rot-in 299.02 APE67-dihe-in -61.0, -22.55 -46.4, -40.51 APE12-dist-in 11.177 APE11-dist-out 5.772 APE10-dist-out 9.457 APE9-dist-in 4.556 None None None XRAY 1.7 0.18 0.217 A 294 274 2 0 0 0 [[13, 275]] 1.0 3eh9 CAMK_DAPK1_HUMAN CAMK 6.1e-95 323.3 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3F5GA P53355 2 277 1430.0 ADP:60001 ATPlike Inactive DFGin 6.685 13.968 BLAminus -120.45, 179.24 65.08, 83.1 -97.05, 24.31 287.76, 77.76 -68.45, -21.11 in-in in 9.307 Saltbr-in 2.797 HRD-in -76.76, -45.85 68.91, 8.76 in-in-out SNCiio in-out ActLoopNT-in 2.914 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -92.45, 115.11 APE9-dihe-na -89.86, -138.22 APE8-dihe-in -85.51, 124.34 APE8-rot-in 301.38 APE67-dihe-in -61.82, -27.25 -45.2, -42.29 APE12-dist-in 11.024 APE11-dist-out 5.774 APE10-dist-out 9.48 APE9-dist-in 4.623 None None None XRAY 1.85 0.188 0.244 A 294 276 0 0 0 0 [[13, 275]] 1.0 3f5g CAMK_DAPK1_HUMAN CAMK 6.1e-95 323.3 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 2W4KA P53355 2 302 1430.0 ADP:1303 ATPlike Active DFGin 6.672 14.178 BLAminus -119.76, -176.11 66.35, 79.87 -97.37, 22.41 282.66, 74.96 -63.58, -22.08 in-in in 9.11 Saltbr-in 2.829 HRD-in -72.34, -46.15 68.63, 4.94 in-in-in SNCiii in-in ActLoopNT-in 2.866 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.51, 175.21 APE9-dihe-na 86.37, -178.83 APE8-dihe-in -92.32, 120.41 APE8-rot-in 301.2 APE67-dihe-in -65.94, -16.49 -43.92, -47.7 APE12-dist-in 9.204 APE11-dist-in 12.288 APE10-dist-in 6.82 APE9-dist-in 5.132 None None None XRAY 1.9 0.195 0.228 A 302 301 0 0 0 0 [[13, 275]] 1.0 2w4k CAMK_DAPK1_HUMAN CAMK 6.8e-95 323.2 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3GU6A P53355 2 277 1430.0 ADP:60296 ATPlike Inactive DFGin 6.703 14.015 BLAminus -123.16, -179.19 61.96, 78.37 -92.65, 24.29 287.26, 76.41 -68.7, -18.31 in-in in 9.083 Saltbr-in 2.722 HRD-in -78.16, -47.73 70.74, 4.81 in-in-out SNCiio in-out ActLoopNT-in 2.917 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -153.98, 117.17 APE9-dihe-na -91.62, -149.81 APE8-dihe-in -81.71, 126.34 APE8-rot-in 293.82 APE67-dihe-in -55.19, -26.27 -45.69, -42.2 APE12-dist-in 10.008 APE11-dist-out 6.601 APE10-dist-out 9.418 APE9-dist-in 4.349 Q23V None None XRAY 1.49 0.185 0.213 A 295 276 0 0 0 0 [[13, 275]] 1.0 3gu6 CAMK_DAPK1_HUMAN CAMK 2.1e-94 321.5 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3GU7A P53355 2 277 1430.0 ADP:60296 ATPlike Inactive DFGin 6.697 14.121 BLAminus -119.64, -175.75 62.96, 82.16 -94.9, 24.89 284.57, 77.57 -70.06, -20.41 in-in in 9.248 Saltbr-in 2.787 HRD-in -79.97, -44.14 64.75, 4.23 in-in-out SNCiio in-out ActLoopNT-in 2.943 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -162.1, 115.0 APE9-dihe-na -94.82, -140.46 APE8-dihe-in -83.81, 124.48 APE8-rot-in 298.21 APE67-dihe-in -60.5, -27.71 -46.69, -42.88 APE12-dist-in 11.2 APE11-dist-out 6.383 APE10-dist-out 9.438 APE9-dist-in 4.626 Q23V None None XRAY 1.9 0.173 0.228 A 295 276 0 0 0 0 [[13, 275]] 1.0 3gu7 CAMK_DAPK1_HUMAN CAMK 2.1e-94 321.5 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 2XUUA P53355 2 302 1430.0 ADP:1303 ATPlike Active DFGin 6.814 14.3 BLAminus -117.01, 179.93 67.97, 81.82 -97.7, 27.63 286.42, 73.81 -75.99, -13.96 in-in in 9.047 Saltbr-in 2.623 HRD-in -76.48, -45.49 71.86, 3.84 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -168.39, 167.91 APE9-dihe-na 89.82, 178.63 APE8-dihe-in -101.18, 124.0 APE8-rot-in 296.23 APE67-dihe-in -60.21, -22.55 -44.54, -47.64 APE12-dist-in 8.87 APE11-dist-in 11.727 APE10-dist-in 6.406 APE9-dist-in 5.145 E182A None None XRAY 1.8 0.179 0.226 A 334 301 0 0 0 0 [[13, 275]] 1.0 2xuu CAMK_DAPK1_HUMAN CAMK 1.4e-94 322.3 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK MAPKAPK2 MAPK2_HUMAN 1NY3A P49137 46 345 400.0 ADP:401 ATPlike Inactive DFGin 4.213 13.918 BLAminus -139.11, 173.49 82.65, 112.5 -121.18, 20.23 280.18, 65.28 -53.92, -18.87 out-out out 10.039 Saltbr-out 6.106 HRD-in -63.84, -48.41 55.55, 34.09 out-in-none SNCoin in-none ActLoopNT-in 2.981 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -47.32, -19.47 999.0, 98.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.27 0.292 A 400 277 23 0 0 9 [[63, 325]] 1.0 1ny3 CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK PASK PASK_HUMAN 3DLSA Q96RG2 982 1266 1323.0 ADP:1 ATPlike Active DFGin 6.001 14.204 BLAminus -129.0, 178.94 63.52, 79.16 -100.96, 27.03 282.44, 72.76 -70.92, -15.42 in-in in 8.655 Saltbr-in 2.605 HRD-na-E -71.55, -40.2 72.7, 1.22 in-in-in SNCiii in-in ActLoopNT-in 2.993 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.6, 5.88 APE9-dihe-na -96.65, -154.85 APE8-dihe-in -98.92, 122.93 APE8-rot-in 302.12 APE67-dihe-in -72.66, -14.95 -65.45, -19.89 APE12-dist-in 10.203 APE11-dist-in 10.574 APE10-dist-in 5.061 APE9-dist-in 3.451 None None None XRAY 2.3 0.244 0.297 A 335 285 0 0 0 0 [[999, 1251]] 1.0 3dls CAMK_PASK_HUMAN CAMK 2.7e-67 232.8 1 256 256 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN 3DLSB Q96RG2 982 1267 1323.0 ADP:2 ATPlike Active DFGin 6.1 14.087 BLAminus -126.55, 179.43 61.31, 80.64 -98.16, 22.24 284.4, 71.69 -72.83, -6.95 in-in in 8.346 Saltbr-in 2.677 HRD-na-E -67.25, -43.38 72.94, 0.56 in-in-in SNCiii in-in ActLoopNT-in 2.921 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.86, 22.09 APE9-dihe-na -121.63, -155.86 APE8-dihe-in -97.56, 124.97 APE8-rot-in 306.83 APE67-dihe-in -68.7, -17.81 -61.84, -27.67 APE12-dist-in 10.243 APE11-dist-in 10.688 APE10-dist-in 5.149 APE9-dist-in 3.521 None None None XRAY 2.3 0.244 0.297 B 335 280 6 0 0 0 [[999, 1251]] 1.0 3dls CAMK_PASK_HUMAN CAMK 2.7e-67 232.8 1 256 256 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN 3DLSC Q96RG2 982 1267 1323.0 ADP:3 ATPlike Active DFGin 6.549 14.136 BLAminus -121.24, -178.98 61.8, 81.93 -100.03, 24.34 279.06, 77.86 -70.4, -24.84 in-in in 8.286 Saltbr-in 2.707 HRD-na-E -75.53, -39.96 73.3, -0.15 in-in-in SNCiii in-in ActLoopNT-in 2.808 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -109.16, 23.96 APE9-dihe-na -111.98, -161.37 APE8-dihe-in -95.46, 124.23 APE8-rot-in 302.16 APE67-dihe-in -72.29, -18.02 -57.94, -30.36 APE12-dist-in 9.98 APE11-dist-in 10.437 APE10-dist-in 4.962 APE9-dist-in 3.466 None None None XRAY 2.3 0.244 0.297 C 335 281 5 0 0 0 [[999, 1251]] 1.0 3dls CAMK_PASK_HUMAN CAMK 2.7e-67 232.8 1 256 256 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN 3DLSD Q96RG2 982 1266 1323.0 ADP:4 ATPlike Active DFGin 5.989 14.037 BLAminus -119.78, -174.43 57.15, 82.44 -96.61, 20.08 283.36, 68.59 -63.18, -13.75 in-in in 8.596 Saltbr-in 2.674 HRD-na-E -66.59, -43.13 75.45, -3.58 in-in-in SNCiii in-in ActLoopNT-in 2.812 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.17, 8.76 APE9-dihe-na -100.36, -154.44 APE8-dihe-in -94.34, 129.8 APE8-rot-in 309.84 APE67-dihe-in -63.24, -17.05 -59.73, -34.41 APE12-dist-in 10.579 APE11-dist-in 10.601 APE10-dist-in 5.212 APE9-dist-in 3.318 None None None XRAY 2.3 0.244 0.297 D 335 284 1 0 0 0 [[999, 1251]] 1.0 3dls CAMK_PASK_HUMAN CAMK 2.7e-67 232.8 1 256 256 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN 3DLSE Q96RG2 982 1267 1323.0 ADP:5 ATPlike Active DFGin 6.351 14.113 BLAminus -115.03, 172.38 61.43, 82.92 -98.38, 26.76 287.19, 66.36 -61.94, -22.57 in-in in 8.272 Saltbr-in 3.015 HRD-na-E -64.64, -41.08 75.56, -14.47 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.8, 6.63 APE9-dihe-na -93.38, -160.98 APE8-dihe-in -92.63, 131.98 APE8-rot-in 304.09 APE67-dihe-in -71.09, -14.17 -58.49, -32.88 APE12-dist-in 10.767 APE11-dist-in 10.575 APE10-dist-in 5.072 APE9-dist-in 3.423 None None None XRAY 2.3 0.244 0.297 E 335 282 4 0 0 0 [[999, 1251]] 1.0 3dls CAMK_PASK_HUMAN CAMK 2.7e-67 232.8 1 256 256 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN 3DLSF Q96RG2 982 1266 1323.0 ADP:6 ATPlike Active DFGin 6.208 14.428 BLAminus -120.86, -179.45 54.8, 74.61 -87.61, 27.75 280.29, 66.66 -72.72, -14.22 in-in in 8.492 Saltbr-in 2.879 HRD-na-E -64.59, -48.9 86.1, -8.79 in-in-in SNCiii in-in ActLoopNT-in 2.704 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.3, 4.74 APE9-dihe-na -89.15, -152.34 APE8-dihe-in -104.88, 132.7 APE8-rot-in 302.97 APE67-dihe-in -72.03, -17.52 -62.59, -27.45 APE12-dist-in 10.486 APE11-dist-in 10.547 APE10-dist-in 5.101 APE9-dist-in 3.284 None None None XRAY 2.3 0.244 0.297 F 335 281 4 0 0 0 [[999, 1251]] 1.0 3dls CAMK_PASK_HUMAN CAMK 2.7e-67 232.8 1 256 256 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK STK17B ST17B_HUMAN 6QF4A O94768 18 308 372.0 ADP:405 ATPlike Inactive DFGin 6.252 14.589 BLAminus -138.0, 178.42 64.68, 88.16 -110.19, 27.69 285.51, 77.31 -64.42, -20.01 out-out out 10.293 Saltbr-out 4.396 HRD-in -72.0, -51.78 71.09, 16.02 out-in-out SNCoio in-out ActLoopNT-in 3.129 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioo APE10-dihe-na -151.1, 167.46 APE9-dihe-na 109.33, 178.09 APE8-dihe-in -61.1, 118.93 APE8-rot-in 322.5 APE67-dihe-in -69.8, -8.25 -54.96, -33.39 APE12-dist-none 999.0 APE11-dist-in 12.911 APE10-dist-out 10.081 APE9-dist-out 7.839 None None None XRAY 2.495 0.187 0.227 A 327 287 4 0 0 4 [[32, 293]] 1.0 6qf4 CAMK_STK17B_HUMAN CAMK 1.4e-81 279.8 4 256 253 178 179 180 182 184 62 80 84 155 157 156 158 217 205 200 199 198 197 196 195 194 111 Serine/threonine-protein kinase 17B
CAMK STK17B ST17B_HUMAN 7Q7CA O94768 25 297 372.0 ADP:60402 ATPlike None DFGin 5.672 13.983 BLAminus -146.28, 174.77 69.66, 80.54 -103.01, 24.61 291.62, 86.01 -65.04, -13.43 in-in in 9.403 Saltbr-in 3.35 HRD-in -84.64, -49.74 76.32, -16.47 in-in-none SNCiin in-none ActLoopNT-in 3.297 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 143.13 APE8-rot-in 309.53 APE67-dihe-in -65.37, -16.14 -54.33, -43.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.85 0.21 0.238 A 327 265 8 0 0 8 [[32, 293]] 1.0 7q7c CAMK_STK17B_HUMAN CAMK 1.4e-81 279.8 4 256 253 178 179 180 182 184 62 80 84 155 157 156 158 217 205 200 199 198 197 196 195 194 111 Serine/threonine-protein kinase 17B
CK1 CSNK1D KC1D_HUMAN 6RU7A P48730 3 294 415.0 ADP:60301 Type1.5_Back Active DFGin 6.392 15.125 BLAminus -134.23, -173.24 59.44, 80.86 -96.06, 22.96 285.76, 78.27 -62.92, -27.34 in-in in 7.971 Saltbr-in 2.803 HRD-in -82.18, -50.23 72.61, 5.15 in-in-in SNCiii in-in ActLoopNT-in 2.884 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.24, 126.6 APE9-dihe-na 114.96, -145.11 APE8-dihe-in -115.28, 122.22 APE8-rot-in 302.31 APE67-dihe-in -56.73, -38.36 -50.64, -46.9 APE12-dist-in 12.381 APE11-dist-in 12.179 APE10-dist-in 6.834 APE9-dist-in 3.511 None None None XRAY 2.08 0.177 0.218 A 296 292 0 0 0 0 [[9, 275]] 1.0 6ru7 CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RU7B P48730 3 294 415.0 ADP:60301 Type1.5_Back Active DFGin 6.618 14.988 BLAminus -130.01, -176.4 60.72, 81.81 -97.28, 21.17 286.1, 78.89 -61.41, -29.58 in-in in 7.795 Saltbr-in 2.912 HRD-in -81.31, -50.84 72.75, 6.38 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.97, 131.36 APE9-dihe-na 113.79, -145.67 APE8-dihe-in -115.43, 125.17 APE8-rot-in 305.08 APE67-dihe-in -54.67, -36.6 -52.93, -49.24 APE12-dist-in 13.297 APE11-dist-in 12.156 APE10-dist-in 6.649 APE9-dist-in 3.527 None None None XRAY 2.08 0.177 0.218 B 296 288 4 0 0 4 [[9, 275]] 1.0 6ru7 CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RU8A P48730 2 294 415.0 ADP:60301 Type1.5_Back Active DFGin 6.425 15.156 BLAminus -131.62, -177.15 63.45, 81.35 -98.16, 25.89 286.32, 78.16 -68.14, -23.3 in-in in 7.926 Saltbr-in 2.803 HRD-in -87.78, -47.56 70.02, 4.06 in-in-in SNCiii in-in ActLoopNT-in 2.84 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.49, 136.29 APE9-dihe-na 109.45, -154.85 APE8-dihe-in -109.19, 121.34 APE8-rot-in 302.42 APE67-dihe-in -58.68, -38.47 -55.68, -42.0 APE12-dist-in 13.563 APE11-dist-in 12.282 APE10-dist-in 6.892 APE9-dist-in 3.572 None None None XRAY 1.92 0.174 0.211 A 296 293 0 0 0 0 [[9, 275]] 1.0 6ru8 CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RU8B P48730 2 294 415.0 ADP:60301 Type1.5_Back Active DFGin 6.591 15.264 BLAminus -131.67, -177.68 64.26, 82.5 -98.0, 23.89 285.39, 79.53 -66.54, -22.27 in-in in 7.662 Saltbr-in 2.78 HRD-in -88.75, -48.7 67.58, 11.08 in-in-in SNCiii in-in ActLoopNT-in 2.853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.47, 142.8 APE9-dihe-na 95.33, -164.73 APE8-dihe-in -102.94, 120.03 APE8-rot-in 301.71 APE67-dihe-in -59.39, -37.33 -59.11, -40.45 APE12-dist-in 12.308 APE11-dist-in 12.295 APE10-dist-in 7.245 APE9-dist-in 3.892 None None None XRAY 1.92 0.174 0.211 B 296 293 0 0 0 0 [[9, 275]] 1.0 6ru8 CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RU8C P48730 2 294 415.0 ADP:60301 Type1.5_Back Active DFGin 6.558 14.983 BLAminus -128.29, -179.37 66.68, 80.46 -98.0, 22.92 288.66, 76.31 -64.33, -23.77 in-in in 7.948 Saltbr-in 2.77 HRD-in -82.99, -49.18 72.75, 4.46 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.59, 138.55 APE9-dihe-na 101.61, -152.03 APE8-dihe-in -108.82, 122.86 APE8-rot-in 298.47 APE67-dihe-in -58.74, -36.85 -58.82, -40.4 APE12-dist-in 13.04 APE11-dist-in 12.435 APE10-dist-in 6.868 APE9-dist-in 3.607 None None None XRAY 1.92 0.174 0.211 C 296 287 6 0 0 6 [[9, 275]] 1.0 6ru8 CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RU8D P48730 2 294 415.0 ADP:60301 Type1.5_Back Active DFGin 6.534 14.975 BLAminus -126.38, -177.59 65.46, 80.95 -97.97, 21.9 288.13, 75.77 -63.86, -25.32 in-in in 7.979 Saltbr-in 2.782 HRD-in -86.34, -48.63 71.97, 3.09 in-in-in SNCiii in-in ActLoopNT-in 2.81 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.34, 138.88 APE9-dihe-na 102.71, -155.7 APE8-dihe-in -106.76, 124.41 APE8-rot-in 298.22 APE67-dihe-in -58.88, -36.36 -58.72, -41.76 APE12-dist-in 12.717 APE11-dist-in 12.352 APE10-dist-in 6.743 APE9-dist-in 3.59 None None None XRAY 1.92 0.174 0.211 D 296 293 0 0 0 0 [[9, 275]] 1.0 6ru8 CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 TTBK1 TTBK1_HUMAN 4BTJA Q5TCY1 21 312 1321.0 ADP:61337 ATPlike Active DFGin 5.513 12.699 BLAminus -122.16, 167.53 65.74, 92.18 -107.62, 12.94 309.85, 113.04 -64.35, -28.29 in-in in 7.127 Saltbr-in 2.757 HRD-in -79.44, -52.71 73.3, -5.89 in-in-in SNCiii in-in ActLoopNT-in 2.821 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.78, 143.11 APE9-dihe-na 98.14, -168.76 APE8-dihe-in -84.14, 153.12 APE8-rot-in 322.08 APE67-dihe-in -60.57, -38.77 -75.21, -43.81 APE12-dist-in 11.388 APE11-dist-in 11.45 APE10-dist-in 5.945 APE9-dist-in 3.412 None None None XRAY 2.16 0.179 0.197 A 337 292 0 0 0 0 [[34, 295]] 1.0 4btj CK1_TTBK1_HUMAN CK1 5.7e-105 356.4 1 262 262 175 176 177 179 181 63 77 81 151 153 152 154 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
CK1 TTBK2 TTBK2_HUMAN 6VRFA Q6IQ55 9 298 1244.0 ADP:301 ATPlike Active DFGin 5.354 13.116 BLAminus -121.29, 164.21 73.75, 82.24 -97.72, 13.38 304.67, 116.94 -64.06, -29.66 in-in in 7.214 Saltbr-in 2.751 HRD-in -77.1, -49.95 73.69, -4.56 in-in-in SNCiii in-in ActLoopNT-in 2.813 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.12, -30.06 APE9-dihe-na -84.65, -146.34 APE8-dihe-in -107.58, 129.44 APE8-rot-in 302.21 APE67-dihe-in -59.13, -37.2 -56.28, -42.66 APE12-dist-in 11.197 APE11-dist-in 11.387 APE10-dist-in 5.48 APE9-dist-in 3.784 None None None XRAY 1.5 0.175 0.209 A 299 287 3 0 0 0 [[21, 282]] 1.0 6vrf CK1_TTBK2_HUMAN CK1 7.7e-104 352.6 1 262 262 162 163 164 166 168 50 64 68 138 140 139 141 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2
CK1 TTBK2 TTBK2_HUMAN 6VRFB Q6IQ55 9 298 1244.0 ADP:301 ATPlike Active DFGin 5.431 12.695 BLAminus -121.38, 163.64 74.07, 85.5 -102.64, 12.86 306.76, 116.33 -62.94, -32.7 in-in in 7.346 Saltbr-in 2.891 HRD-in -78.31, -51.54 73.55, 1.77 in-in-in SNCiii in-in ActLoopNT-in 2.86 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -109.78, -23.36 APE9-dihe-na -86.88, -149.11 APE8-dihe-in -108.63, 128.02 APE8-rot-in 302.45 APE67-dihe-in -58.2, -36.14 -56.96, -43.7 APE12-dist-in 11.039 APE11-dist-in 11.244 APE10-dist-in 5.337 APE9-dist-in 3.712 None None None XRAY 1.5 0.175 0.209 B 299 287 3 0 0 0 [[21, 282]] 1.0 6vrf CK1_TTBK2_HUMAN CK1 7.7e-104 352.6 1 262 262 162 163 164 166 168 50 64 68 138 140 139 141 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2
CMGC CDK11B CD11B_HUMAN 9I9IK P21127 440 740 795.0 ADP:60801 ATPlike Inactive DFGin 4.763 14.146 BLAminus -158.41, -152.11 58.37, 65.02 -86.96, 23.61 281.98, 74.01 -65.45, -34.44 in-in in 9.348 Saltbr-in 3.025 HRD-in -87.02, -49.1 60.47, 15.99 in-in-out SNCiio in-out ActLoopNT-in 2.843 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -140.14, 178.62 APE9-dihe-na 67.65, 142.84 APE8-dihe-in -66.76, 156.24 APE8-rot-out 57.56 APE67-dihe-in -70.3, -10.82 -63.46, -38.5 APE12-dist-in 13.294 APE11-dist-in 11.398 APE10-dist-in 6.513 APE9-dist-in 3.289 None TPO595 TPO595 EM 3.5 999.0 999.0 K 442 268 35 0 0 6 [[438, 723]] 1.0 9i9i CMGC_CDK11B_HUMAN CMGC 5.1e-79 271.6 1 301 301 579 580 581 583 585 467 485 489 559 561 560 562 620 607 602 601 600 599 598 597 596 517 Cyclin-dependent kinase 11B
CMGC CDK12 CDK12_HUMAN 4NSTA Q9NYV4 716 1046 1490.0 ADP:1101 ATPlike Inactive DFGin 6.978 15.111 BLAminus -127.54, 179.84 60.58, 76.06 -95.3, 23.79 283.73, 86.71 -65.43, -16.77 in-in in 8.988 Saltbr-in 3.031 HRD-in -82.28, -56.37 71.8, 9.39 in-in-out SNCiio in-out ActLoopNT-in 2.956 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -128.59, 153.12 APE9-dihe-na 76.09, 132.29 APE8-dihe-in -60.41, 149.83 APE8-rot-out 85.48 APE67-dihe-in -64.83, -28.79 -60.07, -39.7 APE12-dist-in 13.247 APE11-dist-in 11.273 APE10-dist-in 6.995 APE9-dist-in 3.461 None TPO893 TPO893 XRAY 2.2 0.198 0.24 A 351 323 8 0 0 0 [[727, 1020]] 1.0 4nst CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 4NSTC Q9NYV4 717 1045 1490.0 ADP:1101 ATPlike Inactive DFGin 6.972 15.168 BLAminus -122.49, -178.57 55.97, 75.42 -92.86, 20.68 283.24, 86.31 -56.98, -20.08 in-in in 8.863 Saltbr-in 2.957 HRD-in -69.12, -51.54 66.96, 15.75 in-in-out SNCiio in-out ActLoopNT-in 2.928 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.74, 152.42 APE9-dihe-na 82.09, 126.12 APE8-dihe-in -62.22, 152.62 APE8-rot-out 78.32 APE67-dihe-in -63.16, -30.08 -57.73, -42.25 APE12-dist-in 13.202 APE11-dist-in 11.267 APE10-dist-in 6.942 APE9-dist-in 3.705 None TPO893 TPO893 XRAY 2.2 0.198 0.24 C 351 318 11 0 0 1 [[727, 1020]] 1.0 4nst CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK13 CDK13_HUMAN 5EFQA Q14004 695 1025 1512.0 ADP:1101 ATPlike Inactive DFGin 6.755 15.589 BLAminus -141.88, 177.76 70.28, 48.66 -74.58, 17.49 278.28, 85.63 -61.09, -20.11 in-in in 8.116 Saltbr-in 2.814 HRD-in -86.6, -50.11 69.54, 11.28 in-in-out SNCiio in-out ActLoopNT-in 3.137 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -127.03, -45.46 APE9-dihe-na -90.96, 147.77 APE8-dihe-in -58.82, 149.25 APE8-rot-out 183.76 APE67-dihe-in -63.13, -14.28 -57.08, -47.49 APE12-dist-in 13.272 APE11-dist-in 11.121 APE10-dist-in 6.954 APE9-dist-in 3.353 None TPO871 TPO871 XRAY 2.0 0.197 0.247 A 347 322 9 0 0 0 [[705, 998]] 1.0 5efq CMGC_CDK13_HUMAN CMGC 2.2e-85 292.5 1 301 301 854 855 856 858 860 734 752 756 834 836 835 837 896 883 878 877 876 875 874 873 872 792 Cyclin-dependent kinase 13
CMGC CDK13 CDK13_HUMAN 5EFQC Q14004 697 1031 1512.0 ADP:1101 ATPlike Inactive DFGin 6.671 15.396 BLAminus -141.53, 176.29 69.41, 51.5 -75.76, 17.57 280.54, 75.34 -60.62, -20.31 in-in in 8.109 Saltbr-in 2.945 HRD-in -87.13, -51.3 69.73, 13.1 in-in-out SNCiio in-out ActLoopNT-in 2.938 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -124.45, -44.56 APE9-dihe-na -90.13, 148.33 APE8-dihe-in -57.19, 149.29 APE8-rot-out 181.48 APE67-dihe-in -63.2, -13.36 -56.43, -47.06 APE12-dist-in 13.404 APE11-dist-in 11.586 APE10-dist-in 7.079 APE9-dist-in 3.345 None TPO871 TPO871 XRAY 2.0 0.197 0.247 C 347 326 9 0 0 0 [[705, 998]] 1.0 5efq CMGC_CDK13_HUMAN CMGC 2.2e-85 292.5 1 301 301 854 855 856 858 860 734 752 756 834 836 835 837 896 883 878 877 876 875 874 873 872 792 Cyclin-dependent kinase 13
CMGC CDK2 CDK2_HUMAN 4I3ZA P24941 1 296 298.0 ADP:60301 ATPlike Active DFGin 6.408 15.148 BLAminus -137.57, -176.06 52.96, 75.44 -91.33, 19.91 280.72, 70.75 -64.88, -19.38 in-in in 8.599 Saltbr-in 2.988 HRD-in -80.76, -55.87 72.55, 4.85 in-in-in SNCiii in-in ActLoopNT-in 2.901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.11, -96.25 APE9-dihe-na -51.92, 142.27 APE8-dihe-in -55.11, 135.08 APE8-rot-in 307.48 APE67-dihe-in -54.58, -26.51 -40.4, -56.95 APE12-dist-in 13.064 APE11-dist-in 10.585 APE10-dist-in 6.823 APE9-dist-in 3.305 None TPO160 TPO160 XRAY 2.05 0.199 0.228 A 296 296 0 0 0 0 [[4, 286]] 1.0 4i3z CMGC_CDK2_HUMAN CMGC 6.2e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4I3ZC P24941 1 296 298.0 ADP:60301 ATPlike Active DFGin 6.367 15.146 BLAminus -139.14, -175.0 51.64, 79.19 -95.11, 18.85 278.6, 70.91 -64.63, -17.11 in-in in 8.653 Saltbr-in 2.979 HRD-in -79.85, -55.96 72.81, 4.84 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.52, -96.18 APE9-dihe-na -52.61, 142.23 APE8-dihe-in -53.61, 133.4 APE8-rot-in 308.84 APE67-dihe-in -53.33, -28.57 -37.02, -58.54 APE12-dist-in 13.081 APE11-dist-in 10.618 APE10-dist-in 6.861 APE9-dist-in 3.305 None TPO160 TPO160 XRAY 2.05 0.199 0.228 C 296 296 0 0 0 0 [[4, 286]] 1.0 4i3z CMGC_CDK2_HUMAN CMGC 6.2e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3QHRA P24941 1 296 298.0 ADP:60297 ATPlike Active DFGin 6.557 15.107 BLAminus -129.61, -176.27 55.27, 75.32 -97.07, 17.79 280.43, 72.68 -60.79, -23.59 in-in in 8.696 Saltbr-in 2.88 HRD-in -78.46, -57.59 71.9, 8.99 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.99, 139.5 APE9-dihe-na 85.76, 129.74 APE8-dihe-in -56.31, 140.07 APE8-rot-in 302.24 APE67-dihe-in -65.07, -20.31 -41.24, -52.35 APE12-dist-in 12.989 APE11-dist-in 10.171 APE10-dist-in 7.111 APE9-dist-in 3.341 None TPO160 TPO160 XRAY 2.17 0.18 0.21 A 298 296 0 0 0 0 [[4, 286]] 1.0 3qhr CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3QHRC P24941 1 296 298.0 ADP:60297 ATPlike Active DFGin 6.565 15.121 BLAminus -133.25, -174.75 53.96, 72.74 -93.36, 15.91 281.14, 71.23 -60.56, -21.49 in-in in 8.7 Saltbr-in 2.868 HRD-in -78.47, -57.15 72.13, 9.85 in-in-in SNCiii in-in ActLoopNT-in 2.876 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.81, 147.52 APE9-dihe-na 81.05, 137.24 APE8-dihe-in -64.2, 137.48 APE8-rot-in 304.68 APE67-dihe-in -62.37, -22.27 -38.55, -53.11 APE12-dist-in 12.985 APE11-dist-in 10.232 APE10-dist-in 6.99 APE9-dist-in 3.293 None TPO160 TPO160 XRAY 2.17 0.18 0.21 C 298 296 0 0 0 0 [[4, 286]] 1.0 3qhr CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3QHWA P24941 1 296 298.0 ADP:60297 ATPlike Active DFGin 6.435 15.013 BLAminus -134.08, -174.07 54.44, 75.18 -91.31, 13.19 281.29, 72.4 -60.66, -23.16 in-in in 8.64 Saltbr-in 2.934 HRD-in -72.46, -52.11 70.84, 4.06 in-in-in SNCiii in-in ActLoopNT-in 2.903 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.61, -86.88 APE9-dihe-na -62.59, 147.47 APE8-dihe-in -61.56, 138.19 APE8-rot-in 297.56 APE67-dihe-in -60.69, -27.39 -44.54, -49.89 APE12-dist-in 12.995 APE11-dist-in 10.23 APE10-dist-in 6.782 APE9-dist-in 3.359 None TPO160 TPO160 XRAY 1.91 0.189 0.219 A 298 296 0 0 0 0 [[4, 286]] 1.0 3qhw CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3QHWC P24941 1 296 298.0 ADP:60297 ATPlike Active DFGin 6.453 15.083 BLAminus -135.33, -175.53 57.5, 71.73 -89.85, 9.67 280.79, 72.12 -55.86, -26.79 in-in in 8.617 Saltbr-in 2.896 HRD-in -73.76, -53.15 71.96, 3.16 in-in-in SNCiii in-in ActLoopNT-in 2.898 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.86, -80.28 APE9-dihe-na -65.52, 146.91 APE8-dihe-in -61.19, 139.69 APE8-rot-in 298.69 APE67-dihe-in -57.2, -28.53 -47.15, -50.79 APE12-dist-in 12.997 APE11-dist-in 10.133 APE10-dist-in 6.722 APE9-dist-in 3.361 None TPO160 TPO160 XRAY 1.91 0.189 0.219 C 298 296 0 0 0 0 [[4, 286]] 1.0 3qhw CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4II5A P24941 1 296 298.0 ADP:60301 ATPlike Active DFGin 6.295 15.275 BLAminus -136.76, -174.67 48.15, 75.69 -89.27, 15.07 281.74, 67.11 -54.49, -30.0 in-in in 8.675 Saltbr-in 2.898 HRD-in -77.95, -58.94 72.46, 5.93 in-in-in SNCiii in-in ActLoopNT-in 2.856 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.58, 147.66 APE9-dihe-na 74.72, 130.64 APE8-dihe-in -63.5, 139.49 APE8-rot-in 303.89 APE67-dihe-in -59.35, -27.46 -47.25, -50.52 APE12-dist-in 13.127 APE11-dist-in 10.372 APE10-dist-in 7.034 APE9-dist-in 3.344 None TPO160 TPO160 XRAY 2.15 0.2 0.226 A 298 296 0 0 0 0 [[4, 286]] 1.0 4ii5 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4II5C P24941 1 296 298.0 ADP:60301 ATPlike Active DFGin 6.289 15.288 BLAminus -134.89, -171.63 44.93, 79.89 -96.21, 16.02 275.02, 74.95 -60.79, -24.87 in-in in 8.666 Saltbr-in 2.94 HRD-in -77.09, -52.7 69.17, 3.7 in-in-in SNCiii in-in ActLoopNT-in 2.858 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.65, 138.88 APE9-dihe-na 85.57, 133.69 APE8-dihe-in -65.51, 139.86 APE8-rot-in 305.2 APE67-dihe-in -60.76, -27.54 -47.35, -49.81 APE12-dist-in 13.141 APE11-dist-in 10.382 APE10-dist-in 7.061 APE9-dist-in 3.387 None TPO160 TPO160 XRAY 2.15 0.2 0.226 C 298 296 0 0 0 0 [[4, 286]] 1.0 4ii5 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9I9JK P24941 6 284 298.0 ADP:60301 ATPlike Inactive DFGin 7.502 16.779 BLAminus -158.16, 171.41 58.55, 63.81 -89.46, 61.19 266.29, 72.56 161.2, 999.0 in-out in 9.119 Saltbr-out 5.255 HRD-in -89.48, -59.44 66.59, -3.23 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -47.83 APE8-dihe-out -98.29, 31.77 APE8-rot-out 77.96 APE67-dihe-in -64.85, -20.6 -65.62, -27.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.13 None None None EM 3.1 999.0 999.0 K 301 246 37 0 0 16 [[4, 286]] 1.0 9i9j CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9I9KK P24941 2 292 298.0 ADP:60301 ATPlike Inactive DFGin 7.302 15.906 BLAminus -142.34, -176.15 60.61, 65.17 -90.86, 48.23 288.67, 80.56 -88.9, -30.85 out-out out 10.486 Saltbr-out 5.65 HRD-in -65.4, -52.43 72.61, -10.3 out-in-out SNCoio in-out ActLoopNT-in 2.558 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -73.37, 146.13 APE9-dihe-na -115.04, 137.49 APE8-dihe-in -60.96, 144.59 APE8-rot-out 184.92 APE67-dihe-in -75.1, -11.28 -107.26, -12.43 APE12-dist-in 12.011 APE11-dist-in 8.187 APE10-dist-out 12.049 APE9-dist-out 7.548 None None None EM 2.4 999.0 999.0 K 301 276 15 0 0 0 [[4, 286]] 1.0 9i9k CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK7 CDK7_HUMAN 9I9IJ P50613 12 310 346.0 ADP:60401 ATPlike Inactive DFGin 6.598 15.148 BLAminus -154.26, -174.63 55.49, 63.23 -84.52, 21.08 280.13, 83.68 -62.16, -39.37 in-out in 8.62 Saltbr-out 4.724 HRD-in -68.87, -48.72 60.83, 9.92 out-in-out SNCoio in-out ActLoopNT-in 2.772 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -114.8, -59.65 APE9-dihe-na -71.54, 157.02 APE8-dihe-in -67.36, 161.57 APE8-rot-out 77.35 APE67-dihe-in -72.1, -35.43 -63.15, -31.03 APE12-dist-in 12.421 APE11-dist-in 11.24 APE10-dist-in 6.135 APE9-dist-in 3.716 None None None EM 3.5 999.0 999.0 J 391 294 5 0 0 0 [[12, 295]] 1.0 9i9i CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 9I9JJ P50613 11 310 346.0 ADP:60401 ATPlike Inactive DFGin 7.046 15.511 BLAminus -142.62, -171.5 55.13, 63.56 -86.1, 20.41 278.63, 86.43 -73.48, -14.71 in-in in 8.475 Saltbr-in 3.262 HRD-in -63.57, -47.3 66.21, -0.54 in-in-out SNCiio in-out ActLoopNT-in 2.876 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -125.41, 160.15 APE9-dihe-na -72.91, 167.58 APE8-dihe-in -60.97, 159.12 APE8-rot-out 182.98 APE67-dihe-in -64.29, -19.96 -63.65, -26.45 APE12-dist-in 11.208 APE11-dist-out 5.341 APE10-dist-out 9.202 APE9-dist-in 4.033 None None None EM 3.1 999.0 999.0 J 391 290 10 0 0 5 [[12, 295]] 1.0 9i9j CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 9I9KJ P50613 10 310 346.0 ADP:60401 ATPlike Inactive DFGin 6.867 15.16 BLAminus -144.56, -175.34 58.29, 64.88 -85.43, 20.68 280.65, 74.04 -68.51, -15.78 in-in in 8.403 Saltbr-in 3.423 HRD-in -66.35, -48.78 67.04, 4.57 in-in-out SNCiio in-out ActLoopNT-in 2.701 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -135.97, 162.75 APE9-dihe-na -69.89, 166.52 APE8-dihe-in -58.19, 147.77 APE8-rot-out 190.67 APE67-dihe-in -62.09, -25.1 -66.28, -24.83 APE12-dist-in 11.543 APE11-dist-out 5.948 APE10-dist-out 9.159 APE9-dist-in 3.891 None None None EM 2.4 999.0 999.0 J 391 301 0 0 0 0 [[12, 295]] 1.0 9i9k CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CSNK2A1 CSK21_HUMAN 6Z19B P68400 2 329 391.0 ADP:401 ATPlike Active DFGin 7.399 16.102 BLAminus -106.47, -175.56 60.6, 79.25 -100.03, 20.37 297.28, 82.12 -73.41, -21.13 in-in in 8.717 Saltbr-in 2.8 HRD-in -71.6, -55.48 75.88, 3.64 in-in-in SNCiii in-in ActLoopNT-in 2.928 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.14, 153.25 APE9-dihe-na 78.4, 166.67 APE8-dihe-in -74.52, 152.52 APE8-rot-in 285.35 APE67-dihe-in -64.18, -23.8 -57.77, -45.77 APE12-dist-in 12.968 APE11-dist-in 10.993 APE10-dist-in 6.495 APE9-dist-in 3.591 None None None XRAY 1.47 0.19 0.221 B 328 328 0 0 0 0 [[39, 324]] 1.0 6z19 CMGC_CSNK2A1_HUMAN CMGC 1.2e-69 240.7 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OQUB P68400 4 327 391.0 ADP:401 ATPlike Active DFGin 7.324 16.392 BLAminus -107.74, -171.87 52.49, 78.62 -101.36, 19.11 291.9, 83.91 -71.23, -12.83 in-in in 9.496 Saltbr-in 2.901 HRD-in -65.86, -46.78 65.2, 13.55 in-in-in SNCiii in-in ActLoopNT-in 2.895 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.87, 169.85 APE9-dihe-na 66.11, 165.52 APE8-dihe-in -87.57, 142.09 APE8-rot-in 294.71 APE67-dihe-in -65.28, -26.45 -36.1, -50.26 APE12-dist-in 12.592 APE11-dist-in 10.419 APE10-dist-in 6.089 APE9-dist-in 3.154 R21S None None XRAY 2.324 0.221 0.244 B 352 324 0 0 0 0 [[39, 324]] 1.0 5oqu CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5ORKB P68400 4 326 391.0 ADP:401 ATPlike Active DFGin 7.365 16.488 BLAminus -111.04, -174.54 54.53, 77.94 -96.47, 19.83 296.01, 82.36 -66.2, -23.13 in-in in 9.552 Saltbr-in 3.041 HRD-in -70.69, -49.04 67.52, 16.07 in-in-in SNCiii in-in ActLoopNT-in 2.862 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.56, 172.18 APE9-dihe-na 65.73, 167.16 APE8-dihe-in -89.89, 143.95 APE8-rot-in 298.57 APE67-dihe-in -64.35, -23.63 -31.56, -56.57 APE12-dist-in 12.614 APE11-dist-in 10.418 APE10-dist-in 6.062 APE9-dist-in 3.149 R21S None None XRAY 2.143 0.217 0.243 B 352 323 0 0 0 0 [[39, 324]] 1.0 5ork CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7QUXA P68400 2 329 391.0 ADP:60401 ATPlike Active DFGin 7.585 16.194 BLAminus -111.52, -172.63 60.82, 80.19 -104.84, 23.49 298.85, 85.23 -72.93, -20.15 in-in in 8.958 Saltbr-in 2.838 HRD-in -72.19, -52.24 72.27, 9.35 in-in-in SNCiii in-in ActLoopNT-in 2.846 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.66, 178.74 APE9-dihe-na 61.29, -172.26 APE8-dihe-in -113.53, 144.19 APE8-rot-in 304.18 APE67-dihe-in -65.08, -18.11 -36.49, -57.4 APE12-dist-in 12.723 APE11-dist-in 10.579 APE10-dist-in 6.214 APE9-dist-in 2.896 None SEP2 SEP2 XRAY 1.48 0.181 0.204 A 352 328 0 0 0 0 [[39, 324]] 1.0 7qux CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6YZHA P68400 3 329 391.0 ADP:60403 ATPlike Active DFGin 7.386 16.31 BLAminus -108.01, -176.38 61.1, 79.34 -99.78, 17.26 297.37, 82.49 -78.41, -8.16 in-in in 9.131 Saltbr-in 2.829 HRD-in -74.51, -47.7 69.86, 14.14 in-in-in SNCiii in-in ActLoopNT-in 2.883 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.83, 175.48 APE9-dihe-na 62.95, -168.81 APE8-dihe-in -126.52, 135.38 APE8-rot-in 299.93 APE67-dihe-in -66.68, -18.66 -34.87, -54.46 APE12-dist-in 12.682 APE11-dist-in 10.343 APE10-dist-in 6.227 APE9-dist-in 3.084 None None None XRAY 1.19 0.173 0.19 A 398 327 0 0 0 0 [[39, 324]] 1.0 6yzh CMGC_CSNK2A1_HUMAN CMGC 2.4e-69 239.8 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6YPNB P68400 2 327 391.0 ADP:401,ADP:403 ATPlike,Allosteric Active DFGin 7.497 16.139 BLAminus -109.68, -177.56 60.98, 76.07 -97.07, 19.64 297.88, 85.05 -61.67, -35.53 in-in in 8.808 Saltbr-in 3.015 HRD-in -64.91, -46.49 66.87, 14.57 in-in-in SNCiii in-in ActLoopNT-in 2.865 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.57, 178.38 APE9-dihe-na 58.61, -169.26 APE8-dihe-in -123.99, 137.29 APE8-rot-in 306.99 APE67-dihe-in -67.45, -16.12 -20.54, -62.85 APE12-dist-in 12.788 APE11-dist-in 10.459 APE10-dist-in 6.269 APE9-dist-in 3.18 None None None XRAY 1.58 0.207 0.247 B 329 326 0 0 0 0 [[39, 324]] 1.0 6ypn CMGC_CSNK2A1_HUMAN CMGC 1.2e-69 240.7 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5CVHA P68400 2 328 391.0 ADP:401,IHP:402 ATPlike,Allosteric Active DFGin 7.351 16.265 BLAminus -108.96, -174.88 56.89, 75.34 -94.42, 15.0 293.73, 80.57 -64.71, -19.68 in-in in 9.418 Saltbr-in 2.869 HRD-in -72.87, -47.99 69.09, 10.68 in-in-in SNCiii in-in ActLoopNT-in 2.901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.61, 174.2 APE9-dihe-na 62.86, 175.04 APE8-dihe-in -103.43, 141.93 APE8-rot-in 298.78 APE67-dihe-in -64.49, -19.58 -33.62, -57.11 APE12-dist-in 12.739 APE11-dist-in 10.544 APE10-dist-in 6.1 APE9-dist-in 3.115 R21S None None XRAY 1.848 0.204 0.22 A 352 327 0 0 0 0 [[39, 324]] 1.0 5cvh CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5CVHB P68400 4 327 391.0 ADP:401,IHP:402 ATPlike,Allosteric Active DFGin 7.334 16.506 BLAminus -108.95, -175.21 55.5, 76.34 -94.47, 15.14 293.04, 80.42 -64.89, -20.52 in-in in 9.652 Saltbr-in 2.92 HRD-in -71.77, -46.42 66.39, 11.3 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.23, 173.23 APE9-dihe-na 63.78, 174.17 APE8-dihe-in -100.91, 142.72 APE8-rot-in 301.86 APE67-dihe-in -62.55, -20.09 -31.2, -58.6 APE12-dist-in 12.631 APE11-dist-in 10.426 APE10-dist-in 6.037 APE9-dist-in 3.119 R21S None None XRAY 1.848 0.204 0.22 B 352 324 0 0 0 0 [[39, 324]] 1.0 5cvh CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5MP8A P68400 3 327 391.0 ADP:404,RKN:406 ATPlike,Allosteric Active DFGin 7.33 16.163 BLAminus -110.84, -174.11 53.51, 76.37 -93.65, 17.26 296.86, 81.68 -66.57, -22.0 in-in in 9.317 Saltbr-in 2.863 HRD-in -67.91, -49.16 67.59, 13.12 in-in-in SNCiii in-in ActLoopNT-in 2.905 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.47, 167.73 APE9-dihe-na 65.86, 165.2 APE8-dihe-in -87.13, 142.99 APE8-rot-in 303.44 APE67-dihe-in -64.04, -21.15 -31.41, -58.51 APE12-dist-in 12.687 APE11-dist-in 10.464 APE10-dist-in 6.121 APE9-dist-in 3.162 R21S None None XRAY 1.92 0.213 0.224 A 352 325 0 0 0 0 [[39, 324]] 1.0 5mp8 CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5MP8B P68400 3 325 391.0 ADP:402,RKN:405 ATPlike,Allosteric Active DFGin 7.324 16.349 BLAminus -110.28, -174.91 53.58, 76.31 -93.48, 18.26 296.68, 81.06 -66.02, -21.8 in-in in 9.448 Saltbr-in 2.907 HRD-in -64.03, -48.98 66.77, 13.43 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.49, 167.73 APE9-dihe-na 66.13, 163.08 APE8-dihe-in -85.62, 144.24 APE8-rot-in 302.43 APE67-dihe-in -63.28, -21.33 -32.96, -58.46 APE12-dist-in 12.646 APE11-dist-in 10.373 APE10-dist-in 6.113 APE9-dist-in 3.151 R21S None None XRAY 1.92 0.213 0.224 B 352 323 0 0 0 0 [[39, 324]] 1.0 5mp8 CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5ORJB P68400 4 327 391.0 ADP:403,A4Q:404 ATPlike,Allosteric Active DFGin 7.265 16.341 BLAminus -111.15, -176.6 55.76, 79.82 -97.57, 16.74 293.2, 81.02 -66.75, -20.87 in-in in 9.479 Saltbr-in 3.015 HRD-in -67.24, -46.68 66.46, 8.84 in-in-in SNCiii in-in ActLoopNT-in 2.969 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.61, 174.53 APE9-dihe-na 65.24, 168.77 APE8-dihe-in -97.72, 138.95 APE8-rot-in 305.57 APE67-dihe-in -64.92, -22.35 -27.33, -57.79 APE12-dist-in 12.61 APE11-dist-in 10.406 APE10-dist-in 6.001 APE9-dist-in 3.126 R21S None None XRAY 1.99 0.201 0.221 B 352 324 0 0 0 0 [[39, 324]] 1.0 5orj CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5ORKA P68400 4 327 391.0 ADP:401,A4T:404 ATPlike,Allosteric Active DFGin 7.393 16.314 BLAminus -113.19, -173.71 54.76, 77.71 -95.81, 17.23 296.74, 84.21 -67.53, -20.95 in-in in 9.357 Saltbr-in 3.023 HRD-in -73.92, -50.16 69.3, 15.04 in-in-in SNCiii in-in ActLoopNT-in 2.873 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.23, 173.79 APE9-dihe-na 63.16, 167.87 APE8-dihe-in -90.44, 143.76 APE8-rot-in 298.85 APE67-dihe-in -64.65, -24.13 -31.17, -56.13 APE12-dist-in 12.631 APE11-dist-in 10.431 APE10-dist-in 6.062 APE9-dist-in 3.164 R21S None None XRAY 2.143 0.217 0.243 A 352 324 0 0 0 0 [[39, 324]] 1.0 5ork CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZYKA P68400 3 329 391.0 ADP:401,KEC:402 ATPlike,Allosteric Active DFGin 7.269 16.062 BLAminus -118.69, -179.59 61.79, 73.49 -91.41, 13.81 296.07, 81.24 -64.93, -20.57 in-in in 9.176 Saltbr-in 3.087 HRD-in -73.86, -46.68 67.1, 11.06 in-in-in SNCiii in-in ActLoopNT-in 2.84 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.3, 165.81 APE9-dihe-na 64.18, 165.94 APE8-dihe-in -85.42, 147.47 APE8-rot-in 296.52 APE67-dihe-in -73.89, -14.69 -37.67, -50.01 APE12-dist-in 12.741 APE11-dist-in 10.382 APE10-dist-in 6.284 APE9-dist-in 3.257 R21S,K74A,K75A,K76A None None XRAY 1.31 0.191 0.206 A 328 327 0 0 0 0 [[39, 324]] 1.0 7zyk CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5MPJA P68400 3 328 391.0 ADP:401,IHP:402,J2P:403 ATPlike,Allosteric,Allosteric Active DFGin 7.347 16.241 BLAminus -108.98, -172.35 51.93, 78.25 -97.48, 15.87 295.39, 81.91 -64.67, -20.13 in-in in 9.407 Saltbr-in 3.123 HRD-in -65.25, -50.84 66.66, 13.27 in-in-in SNCiii in-in ActLoopNT-in 2.941 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.52, 170.99 APE9-dihe-na 63.12, 171.83 APE8-dihe-in -95.06, 139.24 APE8-rot-in 294.97 APE67-dihe-in -59.9, -28.22 -27.45, -59.89 APE12-dist-in 12.787 APE11-dist-in 10.54 APE10-dist-in 6.103 APE9-dist-in 3.163 R21S None None XRAY 2.14 0.214 0.241 A 352 326 0 0 0 0 [[39, 324]] 1.0 5mpj CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OQUA P68400 4 327 391.0 ADP:401,A4B:402,IHP:408 ATPlike,Allosteric,Allosteric Active DFGin 7.448 16.25 BLAminus -109.0, -171.89 53.56, 75.1 -98.21, 18.1 294.2, 83.27 -72.09, -15.18 in-in in 9.369 Saltbr-in 2.827 HRD-in -72.33, -46.9 69.21, 10.87 in-in-in SNCiii in-in ActLoopNT-in 2.966 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.38, 169.57 APE9-dihe-na 63.73, 165.9 APE8-dihe-in -87.91, 142.9 APE8-rot-in 295.65 APE67-dihe-in -63.9, -27.03 -35.31, -52.27 APE12-dist-in 12.67 APE11-dist-in 10.466 APE10-dist-in 6.154 APE9-dist-in 3.14 R21S None None XRAY 2.324 0.221 0.244 A 352 324 0 0 0 0 [[39, 324]] 1.0 5oqu CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OSLA P68400 2 329 391.0 ADP:403,A9K:406,A9K:407 ATPlike,Allosteric,Allosteric Active DFGin 7.458 16.196 BLAminus -110.64, -174.68 55.81, 76.64 -96.18, 20.64 295.73, 82.92 -66.89, -23.66 in-in in 9.121 Saltbr-in 2.879 HRD-in -70.65, -51.51 73.54, 4.25 in-in-in SNCiii in-in ActLoopNT-in 2.987 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.81, 161.35 APE9-dihe-na 64.27, 160.37 APE8-dihe-in -77.24, 145.71 APE8-rot-in 308.44 APE67-dihe-in -67.76, -20.24 -38.72, -52.2 APE12-dist-in 12.834 APE11-dist-in 10.614 APE10-dist-in 6.334 APE9-dist-in 3.627 R21S,K74A,K75A,K76A None None XRAY 1.95 0.165 0.211 A 342 328 0 0 0 0 [[39, 324]] 1.0 5osl CMGC_CSNK2A1_HUMAN CMGC 9.4e-69 237.9 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5MOEB P68400 4 326 391.0 ADP:401,IHP:404,OQC:408,OQC:409 ATPlike,Allosteric,Allosteric,Allosteric Active DFGin 7.365 16.336 BLAminus -112.77, -173.88 54.48, 74.44 -91.99, 16.05 295.46, 80.22 -64.57, -20.81 in-in in 9.479 Saltbr-in 2.889 HRD-in -71.14, -46.59 66.38, 12.51 in-in-in SNCiii in-in ActLoopNT-in 2.873 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.91, 173.34 APE9-dihe-na 63.06, 172.04 APE8-dihe-in -102.52, 138.64 APE8-rot-in 304.11 APE67-dihe-in -65.23, -21.43 -26.29, -58.65 APE12-dist-in 12.604 APE11-dist-in 10.405 APE10-dist-in 6.063 APE9-dist-in 3.115 R21S None None XRAY 1.89 0.197 0.208 B 352 323 0 0 0 0 [[39, 324]] 1.0 5moe CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5ORJA P68400 3 327 391.0 ADP:404,A4Q:405,A4Q:406,IHP:407 ATPlike,Allosteric,Allosteric,Allosteric Active DFGin 7.315 16.182 BLAminus -113.3, -173.8 55.0, 78.92 -98.71, 18.23 293.93, 79.8 -66.17, -22.25 in-in in 9.33 Saltbr-in 3.023 HRD-in -76.84, -43.62 65.1, 10.62 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.05, 173.87 APE9-dihe-na 60.43, 175.34 APE8-dihe-in -100.91, 141.29 APE8-rot-in 294.98 APE67-dihe-in -64.65, -20.18 -32.63, -57.01 APE12-dist-in 12.69 APE11-dist-in 10.523 APE10-dist-in 6.135 APE9-dist-in 3.173 R21S None None XRAY 1.99 0.201 0.221 A 352 325 0 0 0 0 [[39, 324]] 1.0 5orj CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5MOEA P68400 3 327 391.0 ADP:401,IHP:404,OQC:409,OQC:410,OQC:411 ATPlike,Allosteric,Allosteric,Allosteric,Allosteric Active DFGin 7.374 16.184 BLAminus -113.03, -172.32 55.01, 74.02 -92.87, 17.49 295.96, 80.42 -65.27, -21.9 in-in in 9.335 Saltbr-in 2.823 HRD-in -73.11, -47.25 66.93, 11.97 in-in-in SNCiii in-in ActLoopNT-in 2.889 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.86, 173.34 APE9-dihe-na 63.53, 173.35 APE8-dihe-in -101.83, 138.62 APE8-rot-in 302.36 APE67-dihe-in -64.87, -18.25 -29.63, -58.0 APE12-dist-in 12.678 APE11-dist-in 10.501 APE10-dist-in 6.104 APE9-dist-in 3.111 R21S None None XRAY 1.89 0.197 0.208 A 352 325 0 0 0 0 [[39, 324]] 1.0 5moe CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZY0A P68400 3 329 391.0 KC0:401,ADP:402 Allosteric,ATPlike Active DFGin 7.445 16.236 BLAminus -121.24, -177.58 61.58, 73.29 -95.57, 19.56 295.71, 82.78 -68.2, -19.93 in-in in 9.143 Saltbr-in 2.835 HRD-in -73.32, -51.17 71.86, 9.65 in-in-in SNCiii in-in ActLoopNT-in 2.895 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.67, 170.29 APE9-dihe-na 67.14, 162.49 APE8-dihe-in -85.98, 150.23 APE8-rot-in 297.56 APE67-dihe-in -70.24, -15.73 -44.75, -49.95 APE12-dist-in 12.618 APE11-dist-in 10.267 APE10-dist-in 6.142 APE9-dist-in 3.16 R21S,K74A,K75A,K76A None None XRAY 1.44 0.2 0.214 A 328 327 0 0 0 0 [[39, 324]] 1.0 7zy0 CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 8AE7A P68400 3 329 391.0 LVU:403,ADP:404 Allosteric,ATPlike Active DFGin 7.27 16.12 BLAminus -116.86, -174.55 56.89, 71.78 -90.66, 15.89 296.23, 82.47 -66.69, -21.09 in-in in 9.166 Saltbr-in 2.902 HRD-in -74.15, -48.16 69.73, 11.22 in-in-in SNCiii in-in ActLoopNT-in 2.844 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.63, 168.68 APE9-dihe-na 61.6, 159.52 APE8-dihe-in -83.61, 146.39 APE8-rot-in 290.46 APE67-dihe-in -69.61, -14.41 -36.06, -54.13 APE12-dist-in 12.669 APE11-dist-in 10.213 APE10-dist-in 6.181 APE9-dist-in 3.228 R21S,K74A,K75A,K76A None None XRAY 1.28 0.205 0.232 A 328 327 0 0 0 0 [[39, 324]] 1.0 8ae7 CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7I8IA P68400 3 329 391.0 A1BZ5:402,ADP:403 Type1,Allosteric Active DFGin 7.509 16.198 BLAminus -114.79, -179.23 51.74, 77.25 -89.04, 19.22 296.06, 83.25 -67.78, -21.4 in-in in 9.214 Saltbr-in 2.747 HRD-in -73.97, -49.71 72.98, 8.01 in-in-in SNCiii in-in ActLoopNT-in 2.871 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.34, 166.93 APE9-dihe-na 64.1, 155.12 APE8-dihe-in -82.08, 146.04 APE8-rot-in 277.65 APE67-dihe-in -69.99, -12.65 -33.63, -55.35 APE12-dist-in 12.849 APE11-dist-in 10.502 APE10-dist-in 6.346 APE9-dist-in 3.29 R21S,K74A,K75A,K76A None None XRAY 1.47 0.182 0.208 A 328 327 0 0 0 0 [[39, 324]] 1.0 7i8i CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7I8LA P68400 3 329 391.0 A1B0I:401,ADP:402 Type1,Allosteric Active DFGin 7.469 16.174 BLAminus -114.83, -178.51 53.33, 76.08 -89.6, 18.77 294.58, 80.79 -67.15, -22.69 in-in in 9.223 Saltbr-in 2.765 HRD-in -77.98, -46.47 70.26, 9.7 in-in-in SNCiii in-in ActLoopNT-in 2.884 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.24, 169.88 APE9-dihe-na 62.42, 155.06 APE8-dihe-in -81.97, 147.51 APE8-rot-in 279.2 APE67-dihe-in -72.11, -11.91 -35.53, -53.62 APE12-dist-in 12.861 APE11-dist-in 10.518 APE10-dist-in 6.393 APE9-dist-in 3.294 R21S,K74A,K75A,K76A None None XRAY 1.48 0.184 0.203 A 328 327 0 0 0 0 [[39, 324]] 1.0 7i8l CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7I8QA P68400 3 329 391.0 A1BZU:402,ADP:403 Type1,Allosteric Active DFGin 7.479 16.147 BLAminus -114.23, -175.31 54.63, 75.78 -91.18, 24.13 295.07, 81.04 -69.52, -25.94 in-in in 8.973 Saltbr-in 2.76 HRD-in -73.41, -51.65 72.74, 4.84 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.8, 171.34 APE9-dihe-na 61.22, 163.5 APE8-dihe-in -95.71, 145.02 APE8-rot-in 296.25 APE67-dihe-in -71.38, -16.61 -34.03, -51.24 APE12-dist-in 12.809 APE11-dist-in 10.441 APE10-dist-in 6.256 APE9-dist-in 3.114 R21S,K74A,K75A,K76A None None XRAY 1.66 0.191 0.22 A 328 327 0 0 0 0 [[39, 324]] 1.0 7i8q CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC GSK3B GSK3B_HUMAN 4NM5A P49841 24 383 420.0 ADP:60401 ATPlike Active DFGin 6.55 14.006 BLAminus -136.16, -177.73 61.88, 88.47 -108.64, 28.76 287.87, 80.78 -73.66, -15.44 in-in in 8.619 Saltbr-in 2.673 HRD-in -65.83, -43.73 64.82, 15.23 in-in-in SNCiii in-in ActLoopNT-in 2.839 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.92, 173.97 APE9-dihe-na 66.26, 147.02 APE8-dihe-in -77.1, 152.8 APE8-rot-in 293.28 APE67-dihe-inflip 82.03, -25.76 -52.23, 150.7 APE12-dist-in 13.279 APE11-dist-in 11.599 APE10-dist-in 6.949 APE9-dist-in 3.238 None None None XRAY 2.3 0.185 0.232 A 377 360 0 0 0 0 [[56, 340]] 1.0 4nm5 CMGC_GSK3B_HUMAN CMGC 2.3e-70 243.3 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 4NM7A P49841 25 383 420.0 ADP:60401 ATPlike Active DFGin 6.515 13.993 BLAminus -137.35, -178.06 62.82, 88.6 -107.3, 24.56 288.41, 80.2 -69.84, -12.63 in-in in 8.818 Saltbr-in 2.743 HRD-in -66.5, -46.64 67.84, 11.79 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.92, 172.54 APE9-dihe-na 68.99, 153.43 APE8-dihe-in -86.9, 151.79 APE8-rot-in 300.04 APE67-dihe-inflip 84.67, -25.93 -50.38, 146.2 APE12-dist-in 13.355 APE11-dist-in 11.678 APE10-dist-in 6.905 APE9-dist-in 3.21 None None None XRAY 2.3 0.185 0.234 A 377 354 2 0 0 0 [[56, 340]] 1.0 4nm7 CMGC_GSK3B_HUMAN CMGC 2.3e-70 243.3 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 4NM0A P49841 26 383 420.0 ADP:60408 ATPlike Inactive DFGin 6.641 14.213 BLAminus -133.4, -174.33 56.9, 85.51 -105.72, 27.83 287.31, 80.39 -76.48, -2.57 in-in in 8.774 Saltbr-in 3.094 HRD-in -69.87, -45.12 67.03, 14.87 in-in-out SNCiio in-out ActLoopNT-in 2.927 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -71.29, 168.54 APE9-dihe-na 70.19, 144.11 APE8-dihe-in -96.47, 160.21 APE8-rot-out 64.82 APE67-dihe-inflip 78.46, -27.02 -43.67, 149.07 APE12-dist-in 13.091 APE11-dist-in 10.885 APE10-dist-in 6.571 APE9-dist-in 3.135 None None None XRAY 2.5 0.193 0.239 A 389 355 0 0 0 0 [[56, 340]] 1.0 4nm0 CMGC_GSK3B_HUMAN CMGC 2.5e-70 243.2 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 4NM3A P49841 6 383 420.0 ADP:60409 ATPlike Active DFGin 6.475 13.947 BLAminus -129.98, -178.05 63.17, 87.87 -103.96, 21.26 289.38, 80.04 -65.46, -16.35 in-in in 8.806 Saltbr-in 2.726 HRD-in -69.81, -46.77 71.59, 6.75 in-in-in SNCiii in-in ActLoopNT-in 2.75 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.34, 169.99 APE9-dihe-na 69.15, 146.37 APE8-dihe-in -83.47, 151.55 APE8-rot-in 296.54 APE67-dihe-inflip 86.0, -31.11 -49.79, 146.79 APE12-dist-in 13.269 APE11-dist-in 11.484 APE10-dist-in 6.907 APE9-dist-in 3.112 None SEP9 SEP9 XRAY 2.1 0.197 0.242 A 389 357 2 0 0 0 [[56, 340]] 1.0 4nm3 CMGC_GSK3B_HUMAN CMGC 2.5e-70 243.2 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 1J1CA P49841 35 388 420.0 ADP:60430 ATPlike Active DFGin 6.812 13.93 BLAminus -139.24, -179.75 62.79, 82.17 -97.34, 25.19 286.68, 82.3 -65.83, -19.9 in-in in 8.601 Saltbr-in 2.647 HRD-in -68.65, -43.85 68.34, 7.36 in-in-in SNCiii in-in ActLoopNT-in 2.977 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -90.05, 172.96 APE9-dihe-na 78.17, 130.85 APE8-dihe-in -73.54, 145.97 APE8-rot-in 310.16 APE67-dihe-inflip 99.09, -35.01 -54.43, 141.28 APE12-dist-in 13.077 APE11-dist-in 11.067 APE10-dist-in 5.926 APE9-dist-in 3.2 None None None XRAY 2.1 0.218 0.242 A 420 354 0 0 0 0 [[56, 340]] 1.0 1j1c CMGC_GSK3B_HUMAN CMGC 3.2e-70 242.8 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 1J1CB P49841 23 386 420.0 ADP:60930 ATPlike Active DFGin 6.694 13.709 BLAminus -138.27, -179.99 63.33, 82.68 -100.46, 28.2 289.88, 80.26 -70.45, -13.94 in-in in 8.52 Saltbr-in 2.738 HRD-in -67.92, -43.36 67.59, 5.86 in-in-in SNCiii in-in ActLoopNT-in 2.98 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -91.71, 170.27 APE9-dihe-na 78.71, 139.86 APE8-dihe-in -81.56, 140.05 APE8-rot-in 302.5 APE67-dihe-inflip 101.62, -36.53 -50.52, 137.44 APE12-dist-in 12.868 APE11-dist-in 11.128 APE10-dist-in 6.025 APE9-dist-in 3.208 None None None XRAY 2.1 0.218 0.242 B 420 364 0 0 0 0 [[56, 340]] 1.0 1j1c CMGC_GSK3B_HUMAN CMGC 3.2e-70 242.8 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC MAPK1 MK01_HUMAN 4IZ5A P28482 11 357 360.0 ADP:900 ATPlike Inactive DFGin 6.574 16.226 BLAminus -133.03, 170.47 61.68, 96.87 -113.24, 29.97 280.98, 72.88 -75.05, -15.97 in-out in 8.943 Saltbr-out 6.337 HRD-in -70.37, -54.19 76.22, -6.05 out-in-out SNCoio in-out ActLoopNT-in 2.804 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -135.59, 107.64 APE9-dihe-na -86.59, -36.52 APE8-dihe-in -63.86, 130.93 APE8-rot-in 305.07 APE67-dihe-in -64.33, -26.99 -124.19, 30.24 APE12-dist-in 10.012 APE11-dist-out 7.082 APE10-dist-out 8.249 APE9-dist-out 10.51 T185E None None XRAY 3.19 0.245 0.292 A 356 347 0 0 0 0 [[25, 313]] 1.0 4iz5 CMGC_MAPK1_HUMAN CMGC 2.5e-85 292.3 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4IZ5B P28482 11 357 360.0 ADP:900 ATPlike Inactive DFGin 6.614 16.236 BLAminus -130.77, 169.05 63.18, 96.88 -112.33, 27.86 280.9, 72.0 -73.48, -17.21 in-out in 8.952 Saltbr-out 6.284 HRD-in -71.55, -52.24 74.21, -4.59 out-in-out SNCoio in-out ActLoopNT-in 2.846 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -135.05, 108.67 APE9-dihe-na -88.18, -35.19 APE8-dihe-in -65.83, 129.75 APE8-rot-in 303.93 APE67-dihe-in -64.9, -24.28 -122.7, 29.42 APE12-dist-in 10.031 APE11-dist-out 7.085 APE10-dist-out 8.25 APE9-dist-out 10.503 T185E None None XRAY 3.19 0.245 0.292 B 356 347 0 0 0 0 [[25, 313]] 1.0 4iz5 CMGC_MAPK1_HUMAN CMGC 2.5e-85 292.3 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4IZ5C P28482 11 357 360.0 ADP:900 ATPlike Inactive DFGin 6.604 16.232 BLAminus -131.01, 170.44 62.04, 96.83 -112.78, 28.94 280.74, 73.4 -74.17, -17.63 in-out in 8.945 Saltbr-out 6.36 HRD-in -72.88, -51.67 75.48, -6.0 out-in-out SNCoio in-out ActLoopNT-in 2.868 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -133.99, 108.02 APE9-dihe-na -87.46, -36.5 APE8-dihe-in -65.77, 130.32 APE8-rot-in 303.26 APE67-dihe-in -66.37, -24.82 -122.99, 29.53 APE12-dist-in 10.014 APE11-dist-out 7.068 APE10-dist-out 8.22 APE9-dist-out 10.497 T185E None None XRAY 3.19 0.245 0.292 C 356 347 0 0 0 0 [[25, 313]] 1.0 4iz5 CMGC_MAPK1_HUMAN CMGC 2.5e-85 292.3 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4IZ5D P28482 11 357 360.0 ADP:900 ATPlike Inactive DFGin 6.601 16.232 BLAminus -131.94, 170.02 62.64, 97.08 -112.75, 27.73 280.79, 72.08 -72.23, -17.73 in-out in 8.96 Saltbr-out 6.321 HRD-in -71.89, -53.7 75.24, -4.58 out-in-out SNCoio in-out ActLoopNT-in 2.846 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -135.09, 108.16 APE9-dihe-na -88.37, -35.4 APE8-dihe-in -66.59, 130.93 APE8-rot-in 303.88 APE67-dihe-in -65.41, -25.44 -123.75, 30.53 APE12-dist-in 10.012 APE11-dist-out 7.088 APE10-dist-out 8.224 APE9-dist-out 10.46 T185E None None XRAY 3.19 0.245 0.292 D 356 347 0 0 0 0 [[25, 313]] 1.0 4iz5 CMGC_MAPK1_HUMAN CMGC 2.5e-85 292.3 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC PRP4K PRP4K_HUMAN 4IFCA Q13523 668 1005 1007.0 ADP:1101 ATPlike Inactive DFGin 6.321 14.363 BLAminus -121.88, -179.85 58.81, 82.85 -100.37, 25.78 288.2, 87.48 -70.57, -26.82 in-in in 8.257 Saltbr-in 2.844 HRD-in -62.43, -44.6 59.26, 25.1 in-in-out SNCiio in-out ActLoopNT-in 2.816 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -73.15, 134.81 APE9-dihe-na 75.99, 141.41 APE8-dihe-in -55.8, 125.16 APE8-rot-in 286.42 APE67-dihe-in -66.36, -24.99 -29.31, -53.31 APE12-dist-out 15.538 APE11-dist-in 11.831 APE10-dist-out 8.871 APE9-dist-in 3.287 None PTR849 PTR849 XRAY 2.13 0.243 0.256 A 358 328 10 0 0 0 [[687, 1003]] 1.0 4ifc CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
CMGC PRP4K PRP4K_HUMAN 4IFCB Q13523 670 1005 1007.0 ADP:1101 ATPlike Inactive DFGin 6.419 14.343 BLAminus -121.41, 176.18 59.35, 85.75 -102.3, 24.13 289.47, 86.91 -69.6, -26.74 in-in in 8.319 Saltbr-in 2.779 HRD-in -64.36, -42.37 58.06, 25.43 in-in-out SNCiio in-out ActLoopNT-in 2.901 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -73.87, 139.78 APE9-dihe-na 75.02, 140.04 APE8-dihe-in -56.36, 124.13 APE8-rot-in 293.29 APE67-dihe-in -65.74, -25.94 -27.6, -52.65 APE12-dist-out 15.537 APE11-dist-in 11.809 APE10-dist-out 8.576 APE9-dist-in 3.251 None PTR849 PTR849 XRAY 2.13 0.243 0.256 B 358 330 6 0 0 0 [[687, 1003]] 1.0 4ifc CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
CMGC SRPK1 SRPK1_HUMAN 1WBPA Q96SB4 67 655 655.0 ADP:60950 ATPlike Active DFGin 6.093 14.484 BLAminus -120.66, 177.09 55.57, 73.12 -93.78, 28.92 297.48, 63.42 -60.8, -41.52 in-in in 9.616 Saltbr-in 3.534 HRD-in -64.25, -33.37 61.64, -4.85 in-in-in SNCiii in-in ActLoopNT-in 2.855 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.23, 175.25 APE9-dihe-na 64.87, 133.49 APE8-dihe-in -68.33, 140.58 APE8-rot-in 294.72 APE67-dihe-in -48.4, -19.96 -25.96, -79.02 APE12-dist-in 12.421 APE11-dist-in 10.401 APE10-dist-in 7.455 APE9-dist-in 2.973 None None None XRAY 2.4 0.228 0.247 A 397 350 22 0 0 0 [[80, 653]] 1.0 1wbp CMGC_SRPK1_HUMAN CMGC 2e-139 469.9 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
NEK NEK2 NEK2_HUMAN 2W5AA P51955 3 271 445.0 ADP:61280 ATPlike Inactive None 12.645 15.915 None -79.34, 164.62 -62.62, 148.1 -64.74, -38.56 187.15, 76.57 112.78, 109.44 out-out out 13.134 Saltbr-out 14.422 HRD-out -72.83, 129.73 -137.0, 151.51 out-out-out SNCooo out-out ActLoopNT-out 11.638 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -50.6, -46.29 APE9-dihe-na -59.22, 149.78 APE8-dihe-in -97.74, 124.68 APE8-rot-in 301.95 APE67-dihe-out -55.08, -31.55 -81.03, 66.49 APE12-dist-out 14.668 APE11-dist-out 19.148 APE10-dist-out 20.029 APE9-dist-out 14.901 None None None XRAY 1.55 0.173 0.19 A 279 259 10 0 0 3 [[8, 271]] 1.0 2w5a NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK NEK7 NEK7_HUMAN 9NFQC Q8TDX7 20 300 302.0 ADP:1301 ATPlike Inactive DFGin 7.307 11.98 None -150.16, -164.53 74.32, -54.68 63.51, 118.45 304.42, 170.07 -50.32, 115.41 out-out out 14.52 Saltbr-out 10.448 HRD-in -75.46, -45.69 71.31, -4.13 out-out-out SNCooo out-out ActLoopNT-out 9.177 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -73.74, 126.83 APE9-dihe-na 80.61, 29.64 APE8-dihe-in -127.17, 154.0 APE8-rot-out 66.52 APE67-dihe-out -56.05, -43.39 -68.04, 167.92 APE12-dist-out 15.571 APE11-dist-out 14.531 APE10-dist-out 11.825 APE9-dist-out 8.487 None None None XRAY 3.25 0.214 0.261 C 304 281 0 0 0 0 [[34, 294]] 1.0 9nfq NEK_NEK7_HUMAN NEK 4.3e-110 373.2 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 2WQNA Q8TDX7 21 300 302.0 ADP:1301 ATPlike Inactive DFGin 7.366 14.509 None -71.0, 173.16 -64.84, 135.91 -62.15, 999.0 305.22, 52.49 999.0, 999.0 out-out out 14.034 Saltbr-out 12.947 HRD-in -74.75, -50.15 86.13, -19.52 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 77.46 APE8-rot-none 999.0 APE67-dihe-out -63.25, -48.51 -54.4, 143.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.192 0.221 A 310 259 21 0 0 18 [[34, 294]] 1.0 2wqn NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
OTHER BUB1 BUB1_HUMAN 4QPMA O43683 740 1083 1085.0 ADP:61501 ATPlike Inactive DFGin 4.981 12.01 BLAminus -120.67, -179.49 71.42, 87.57 -106.61, 23.42 308.95, 170.82 -66.89, -34.13 in-in in 7.796 Saltbr-in 2.914 HRD-in -66.14, -48.04 82.18, -4.6 in-in-out SNCiio in-out ActLoopNT-in 2.763 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -64.85, 156.56 APE9-dihe-na -64.63, -39.16 APE8-dihe-in -93.29, 139.46 APE8-rot-in 316.87 APE67-dihe-in -78.63, -37.4 -63.71, -30.48 APE12-dist-in 11.725 APE11-dist-out 14.148 APE10-dist-out 10.635 APE9-dist-out 10.792 None SEP969 SEP969 XRAY 2.202 0.231 0.269 A 356 329 15 0 0 0 [[787, 1056]] 1.0 4qpm OTHER_BUB1_HUMAN BUB 3.8e-136 458.4 1 265 265 945 946 947 949 951 821 830 834 914 916 915 917 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN 4QPMB O43683 740 1081 1085.0 ADP:61501 ATPlike Inactive DFGin 5.101 12.046 BLAminus -119.58, -176.38 67.12, 86.64 -105.74, 27.36 310.01, 169.79 -71.02, -28.54 in-in in 7.772 Saltbr-in 2.901 HRD-in -61.72, -45.96 85.02, -11.94 in-in-out SNCiio in-out ActLoopNT-in 2.744 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -63.28, 153.27 APE9-dihe-na -53.34, -51.78 APE8-dihe-in -91.15, 141.66 APE8-rot-in 311.67 APE67-dihe-in -72.26, -39.02 -59.96, -32.38 APE12-dist-in 11.697 APE11-dist-out 14.062 APE10-dist-out 10.116 APE9-dist-out 11.022 None SEP969 SEP969 XRAY 2.202 0.231 0.269 B 356 328 14 0 0 0 [[787, 1056]] 1.0 4qpm OTHER_BUB1_HUMAN BUB 3.8e-136 458.4 1 265 265 945 946 947 949 951 821 830 834 914 916 915 917 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN 4R8QA O43683 736 1083 1085.0 ADP:1501 ATPlike Inactive DFGin 5.122 11.829 BLAminus -125.96, -174.79 66.73, 90.85 -108.81, 15.71 306.38, 172.71 -63.09, -30.66 in-in in 7.711 Saltbr-in 2.874 HRD-in -64.09, -49.64 83.12, -3.69 in-in-out SNCiio in-out ActLoopNT-in 2.763 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iooo APE10-dihe-na -164.58, 163.81 APE9-dihe-na -85.55, 176.61 APE8-dihe-out -73.85, 5.37 APE8-rot-in 315.03 APE67-dihe-out 103.71, -26.99 -140.38, 18.96 APE12-dist-in 11.744 APE11-dist-out 16.324 APE10-dist-out 13.204 APE9-dist-out 6.446 None None None XRAY 2.31 0.226 0.264 A 365 332 16 0 0 0 [[787, 1056]] 1.0 4r8q OTHER_BUB1_HUMAN BUB 4.2e-136 458.3 1 265 265 945 946 947 949 951 821 830 834 914 916 915 917 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN 5DMZA O43683 735 1083 1085.0 ADP:1101 ATPlike Inactive DFGin 5.221 12.068 BLAminus -133.45, -169.91 60.82, 85.13 -106.54, 14.57 302.2, 157.68 -62.7, -37.35 in-out in 7.701 Saltbr-out 3.764 HRD-in -69.13, -48.67 85.78, -11.89 out-in-out SNCoio in-out ActLoopNT-in 2.865 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iooi APE10-dihe-na -165.83, 155.63 APE9-dihe-na -80.56, 157.26 APE8-dihe-out -52.44, -38.51 APE8-rot-in 307.01 APE67-dihe-out 105.78, 2.77 -74.96, -12.99 APE12-dist-in 11.785 APE11-dist-out 16.036 APE10-dist-out 12.54 APE9-dist-in 5.943 None SEP969 SEP969 XRAY 2.4 0.212 0.245 A 365 340 9 0 0 0 [[787, 1056]] 1.0 5dmz OTHER_BUB1_HUMAN BUB 4.2e-136 458.3 1 265 265 945 946 947 949 951 821 830 834 914 916 915 917 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN 5DMZB O43683 735 1083 1085.0 ADP:1101 ATPlike Inactive DFGin 5.22 11.852 BLAminus -128.64, -170.27 62.18, 89.46 -111.04, 16.28 301.8, 159.34 -67.29, -36.18 in-out in 7.572 Saltbr-out 4.025 HRD-in -67.97, -51.5 86.46, -15.21 out-in-out SNCoio in-out ActLoopNT-in 2.845 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iooi APE10-dihe-na -164.62, 154.63 APE9-dihe-na -71.85, 159.91 APE8-dihe-out -55.62, -36.95 APE8-rot-in 307.18 APE67-dihe-out 117.19, -7.42 -77.21, -19.75 APE12-dist-in 11.575 APE11-dist-out 15.552 APE10-dist-out 12.266 APE9-dist-in 5.742 None SEP969 SEP969 XRAY 2.4 0.212 0.245 B 365 340 9 0 0 0 [[787, 1056]] 1.0 5dmz OTHER_BUB1_HUMAN BUB 4.2e-136 458.3 1 265 265 945 946 947 949 951 821 830 834 914 916 915 917 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER CDC7 CDC7_HUMAN 4F99A O00311 41 572 574.0 ADP:601 ATPlike None DFGin 5.87 13.865 BLAminus -125.0, 176.56 71.88, 86.33 -103.78, 20.73 291.54, 82.68 -65.96, -16.39 in-in in 8.793 Saltbr-in 3.139 HRD-in -63.98, -49.82 74.42, -3.19 in-in-none SNCiin in-none ActLoopNT-in 2.732 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -77.05, 117.3 APE8-rot-in 305.41 APE67-dihe-in -66.81, -0.89 -45.84, -42.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.33 0.194 0.241 A 361 312 42 0 0 20 [[58, 569]] 1.0 4f99 OTHER_CDC7_HUMAN CMGC 2e-18 137.7 1 161 295 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 4F9AA O00311 39 572 574.0 ADP:601 ATPlike None DFGin 5.759 13.936 BLAminus -128.61, 175.54 70.41, 87.99 -103.92, 20.97 294.06, 81.72 -65.32, -14.75 in-in in 8.757 Saltbr-in 3.408 HRD-in -57.32, -50.7 72.28, 5.36 in-in-none SNCiin in-none ActLoopNT-in 2.928 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -93.93, 115.55 APE8-rot-in 301.45 APE67-dihe-in -62.39, -13.04 -45.16, -41.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.17 0.208 0.25 A 361 315 41 0 0 20 [[58, 569]] 1.0 4f9a OTHER_CDC7_HUMAN CMGC 2e-18 137.7 1 161 295 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 4F9AC O00311 37 572 574.0 ADP:601 ATPlike None DFGin 5.913 14.207 BLAminus -118.89, -178.58 68.69, 81.33 -98.73, 26.53 287.38, 89.39 -66.37, -28.9 in-in in 8.846 Saltbr-in 2.634 HRD-in -64.95, -54.17 83.11, 0.13 in-in-none SNCiin in-none ActLoopNT-in 2.643 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -84.47, 120.44 APE8-rot-in 299.37 APE67-dihe-in -57.71, -12.62 -43.45, -49.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.17 0.208 0.25 C 361 317 41 0 0 20 [[58, 569]] 1.0 4f9a OTHER_CDC7_HUMAN CMGC 2e-18 137.7 1 161 295 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 6YA7A O00311 39 573 574.0 ADP:60604 ATPlike None DFGin 5.888 14.044 BLAminus -126.02, 169.07 75.11, 84.03 -93.96, 22.86 290.05, 97.62 -71.31, -16.58 in-in in 8.937 Saltbr-in 2.775 HRD-in -69.05, -41.87 77.4, -14.54 in-in-none SNCiin in-none ActLoopNT-in 2.812 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 153.99, -157.91 APE8-dihe-in -128.95, 137.92 APE8-rot-in 297.63 APE67-dihe-inflip 100.28, -12.86 -58.0, 134.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.714 None None None XRAY 1.67 0.158 0.185 A 358 345 5 0 0 5 [[58, 569]] 1.0 6ya7 OTHER_CDC7_HUMAN CMGC 2e-18 137.3 1 161 296 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 375 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 6YA8A O00311 38 572 574.0 ADP:60601,BEF:60603 ATPlike,Allosteric None DFGin 6.168 14.087 BLAminus -118.93, 173.08 76.34, 83.66 -102.33, 21.87 291.62, 81.2 -67.07, -22.7 in-in in 8.709 Saltbr-in 2.738 HRD-in -65.76, -44.2 72.35, -4.4 in-in-none SNCiin in-none ActLoopNT-in 2.755 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na -83.06, -154.71 APE8-dihe-in -48.63, 132.1 APE8-rot-in 306.86 APE67-dihe-in -66.07, -7.37 -59.08, -35.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.888 None None None XRAY 1.79 0.167 0.197 A 359 338 13 0 0 13 [[58, 569]] 1.0 6ya8 OTHER_CDC7_HUMAN CMGC 2e-18 137.3 1 161 296 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 375 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 6D3KA P19525 256 544 551.0 ADP:601 ATPlike Inactive DFGin 6.192 14.114 BLAminus -129.83, -165.99 54.1, 79.73 -96.08, 34.77 294.46, 85.4 -58.44, -36.42 in-in in 8.721 Saltbr-in 3.027 HRD-in -84.66, -50.66 80.44, -19.76 in-in-out SNCiio in-out ActLoopNT-in 2.976 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 139.0 APE8-rot-out 55.24 APE67-dihe-out -85.5, -25.12 -112.78, 51.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.212 0.266 A 323 258 31 0 0 10 [[175, 537]] 1.0 6d3k OTHER_EIF2AK2_HUMAN OTHER 3.5e-49 173.8 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 6D3KB P19525 255 541 551.0 ADP:601 ATPlike Inactive DFGin 6.393 14.221 BLAminus -124.42, -164.03 49.77, 78.4 -95.78, 27.52 286.59, 80.74 -46.98, -40.31 in-in in 8.57 Saltbr-in 2.966 HRD-in -83.22, -38.98 75.5, -28.78 in-in-out SNCiio in-out ActLoopNT-in 3.149 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -18.31 APE8-rot-in 303.08 APE67-dihe-out -107.33, 146.38 64.92, 69.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.212 0.266 B 323 254 33 0 0 11 [[175, 537]] 1.0 6d3k OTHER_EIF2AK2_HUMAN OTHER 3.5e-49 173.8 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 6D3KC P19525 257 541 551.0 ADP:601 ATPlike Inactive DFGin 6.312 14.466 BLAminus -121.59, -161.34 59.64, 70.11 -92.29, 27.04 287.49, 78.94 -65.31, -34.89 in-in in 8.513 Saltbr-in 2.676 HRD-in -58.89, -48.8 72.65, -1.02 in-in-out SNCiio in-out ActLoopNT-in 2.885 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 168.95 APE8-dihe-in -45.87, 135.3 APE8-rot-out 180.18 APE67-dihe-in -61.65, -21.89 -90.59, -3.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.194 None None None XRAY 2.6 0.212 0.266 C 323 258 27 0 0 3 [[175, 537]] 1.0 6d3k OTHER_EIF2AK2_HUMAN OTHER 3.5e-49 173.8 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER ERN1 ERN1_HUMAN 4YZDA O75460 563 964 977.0 ADP:1002 ATPlike Inactive DFGin 7.106 13.454 BLBplus -141.52, 169.79 75.76, 4.13 -62.0, 156.83 53.76, 79.18 72.65, 35.33 out-out out 15.885 Saltbr-out 13.41 HRD-in -64.16, -47.27 74.91, -18.55 out-out-out SNCooo out-out ActLoopNT-out 10.584 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -69.65, 158.55 APE9-dihe-na 98.62, 175.79 APE8-dihe-in -108.17, 135.68 APE8-rot-in 302.59 APE67-dihe-inflip 100.94, -24.59 -56.48, 129.95 APE12-dist-none 999.0 APE11-dist-in 13.406 APE10-dist-out 8.161 APE9-dist-in 3.423 None None None XRAY 3.102 0.234 0.273 A 405 383 18 0 0 12 [[571, 832]] 1.0 4yzd OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZDB O75460 563 963 977.0 ADP:1002 ATPlike Inactive DFGin 7.204 13.179 BLBplus -141.12, 169.65 69.57, 15.58 -67.08, 155.42 48.06, 78.07 72.22, 36.23 out-out out 15.88 Saltbr-out 13.118 HRD-in -63.57, -45.81 74.7, -19.84 out-out-none SNCoon out-none ActLoopNT-out 10.581 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -69.77, 158.99 APE9-dihe-na 99.89, 174.78 APE8-dihe-in -110.07, 134.42 APE8-rot-in 300.85 APE67-dihe-inflip 103.95, -24.75 -57.78, 133.16 APE12-dist-none 999.0 APE11-dist-in 12.672 APE10-dist-in 7.568 APE9-dist-in 3.528 None None None XRAY 3.102 0.234 0.273 B 405 385 15 0 0 12 [[571, 832]] 1.0 4yzd OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZDC O75460 563 964 977.0 ADP:1001 ATPlike Inactive DFGin 7.292 13.556 BLBplus -142.06, 170.34 76.33, 5.28 -64.41, 157.35 50.79, 79.33 73.41, 36.41 out-out out 16.194 Saltbr-out 13.253 HRD-in -63.95, -47.78 74.02, -20.41 out-out-none SNCoon out-none ActLoopNT-out 10.581 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -70.78, 158.57 APE9-dihe-na 97.6, 174.43 APE8-dihe-in -111.17, 134.53 APE8-rot-in 303.43 APE67-dihe-inflip 103.93, -24.42 -56.8, 132.74 APE12-dist-none 999.0 APE11-dist-in 12.41 APE10-dist-in 7.784 APE9-dist-in 3.412 None None None XRAY 3.102 0.234 0.273 C 405 379 21 0 0 12 [[571, 832]] 1.0 4yzd OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 3P23A O75460 563 963 977.0 ADP:1002 ATPlike Inactive DFGin 7.34 13.709 BLBplus -135.51, 176.11 64.76, 22.4 -82.8, 150.63 49.7, 79.84 86.4, 10.86 out-out out 16.088 Saltbr-out 13.069 HRD-in -67.24, -58.17 81.51, -4.45 out-out-out SNCooo out-out ActLoopNT-out 10.402 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -84.29, 161.18 APE9-dihe-na 82.17, -162.33 APE8-dihe-in -132.44, 136.42 APE8-rot-in 302.1 APE67-dihe-inflip 108.83, 5.18 -54.01, 119.49 APE12-dist-none 999.0 APE11-dist-in 12.558 APE10-dist-out 9.123 APE9-dist-in 3.196 None None None XRAY 2.7 0.238 0.294 A 432 386 15 0 0 12 [[571, 832]] 1.0 3p23 OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 3P23B O75460 564 964 977.0 ADP:1002 ATPlike Inactive DFGin 7.483 13.646 BLBplus -139.9, 176.5 76.83, 14.87 -83.89, 150.35 55.49, 87.42 97.57, -33.78 out-out out 15.936 Saltbr-out 12.658 HRD-in -62.38, -39.7 42.05, 35.85 out-out-out SNCooo out-out ActLoopNT-out 9.701 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 143.86 APE9-dihe-na -111.46, -135.27 APE8-dihe-in -106.96, 135.19 APE8-rot-in 295.43 APE67-dihe-inflip 111.53, -14.08 -51.84, 125.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.213 APE9-dist-in 3.477 None None None XRAY 2.7 0.238 0.294 B 432 386 15 0 0 12 [[571, 832]] 1.0 3p23 OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 3P23C O75460 561 964 977.0 ADP:1002 ATPlike Inactive DFGin 7.544 13.173 BLBplus -149.53, -176.42 65.18, 18.98 -70.01, 144.07 39.63, 91.88 97.04, -114.33 out-out out 15.805 Saltbr-out 13.146 HRD-in -52.59, -55.72 76.18, 1.65 out-out-out SNCooo out-out ActLoopNT-out 11.142 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iioi APE10-dihe-na -53.61, -99.6 APE9-dihe-na -77.2, 171.08 APE8-dihe-in -47.05, 145.36 APE8-rot-in 345.28 APE67-dihe-out 116.59, -10.88 85.51, 60.96 APE12-dist-in 12.838 APE11-dist-in 13.243 APE10-dist-out 9.353 APE9-dist-in 3.507 None None None XRAY 2.7 0.238 0.294 C 432 390 14 0 0 11 [[571, 832]] 1.0 3p23 OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 3P23D O75460 561 963 977.0 ADP:1002 ATPlike Inactive DFGin 7.409 13.263 BLBplus -138.88, 177.03 72.28, 10.83 -71.52, 154.68 50.97, 93.75 83.32, -17.5 out-out out 16.034 Saltbr-out 13.018 HRD-in -58.06, -54.76 77.4, -2.34 out-out-out SNCooo out-out ActLoopNT-out 10.057 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnoi APE10-dihe-na 999.0, 162.88 APE9-dihe-na -149.96, -140.99 APE8-dihe-in -73.3, 139.85 APE8-rot-in 325.01 APE67-dihe-out 115.82, -9.19 91.28, 60.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.113 APE9-dist-in 4.038 None None None XRAY 2.7 0.238 0.294 D 432 387 16 0 0 14 [[571, 832]] 1.0 3p23 OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER PIK3R4 PI3R4_HUMAN 8SORA Q99570 15 1358 1358.0 ADP:1401 ATPlike Pseudo DFGin 9.418 15.81 BLBminus -148.68, -163.36 56.86, 40.25 -54.73, 139.1 286.63, 79.79 -95.49, 38.09 out-out out 17.808 Saltbr-out 21.09 HRD-in -78.26, -64.21 93.22, -18.74 out-out-out SNCooo out-out ActLoopNT-out 9.121 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na 53.41, 44.04 APE9-dihe-na -115.24, -10.88 APE8-dihe-out 68.3, 15.78 APE8-rot-na 299.15 APE67-dihe-out -125.94, 101.57 -74.9, 135.12 APE12-dist-out 14.302 APE11-dist-out 17.974 APE10-dist-out 21.055 APE9-dist-out 15.977 None None None EM 3.96 999.0 999.0 A 1358 1156 28 0 0 0 [[19, 321]] 1.0 8sor OTHER_PIK3R4_HUMAN PIK3R4 5.8e-151 507.9 1 298 298 165 166 167 169 171 53 73 77 145 147 146 148 240 200 195 194 193 192 191 190 189 104 Phosphoinositide 3-kinase regulatory subunit 4
OTHER RNASEL RN5A_HUMAN 4OAUC Q05823 25 719 741.0 ADP:801 ATPlike Pseudo DFGin 6.529 12.379 BLAminus -152.72, -178.03 59.98, 103.61 -125.32, 12.02 305.12, 98.0 -75.28, 8.76 in-in in 6.993 Saltbr-in 2.623 HRD-in -74.91, -47.94 67.23, 8.17 in-in-na SNCiia in-na ActLoopNT-in 2.913 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -67.73, 111.98 APE9-dihe-na -66.2, -20.72 APE8-dihe-na -68.67, -28.85 APE8-rot-na 187.68 APE67-dihe-na -72.58, -38.81 -76.25, -36.54 APE12-dist-na 14.068 APE11-dist-na 16.875 APE10-dist-na 14.985 APE9-dist-na 14.333 H672N None None XRAY 2.6 0.213 0.251 C 699 692 0 0 0 0 [[353, 594]] 1.0 4oau OTHER_RNASEL_HUMAN RNASEL 4.1e-136 459.9 1 242 242 502 503 504 506 508 392 404 408 482 484 483 485 520 522 517 516 515 514 513 512 511 435 2-5A-dependent ribonuclease
STE MAP2K1 MP2K1_HUMAN 3EQIA Q02750 39 382 393.0 ADP:2 ATPlike Inactive DFGin 6.097 14.146 BLBplus -145.58, 171.19 59.48, 41.15 -92.75, 128.75 41.67, 88.89 -58.7, 127.06 out-out out 15.214 Saltbr-out 14.728 HRD-in -57.14, -59.8 81.96, -12.14 out-out-out SNCooo out-out ActLoopNT-out 10.702 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -160.04, 114.16 APE9-dihe-na -79.94, 159.35 APE8-dihe-in -52.77, 143.91 APE8-rot-out 201.8 APE67-dihe-in -60.21, -14.42 -106.05, 1.41 APE12-dist-out 20.148 APE11-dist-out 15.239 APE10-dist-out 17.296 APE9-dist-out 9.228 S298N,S299K,Y300F None None XRAY 1.9 0.165 999.0 A 360 315 29 0 0 0 [[68, 361]] 1.0 3eqi STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3MBLA Q02750 62 381 393.0 ADP:60535,LSG:60007 ATPlike,Type3 Inactive DFGin 6.344 13.403 BLBplus -137.82, 175.17 58.41, 36.59 -88.68, 159.6 41.78, 90.19 -90.36, 101.21 out-out out 15.592 Saltbr-out 16.004 HRD-in -72.77, -61.87 90.83, -9.53 out-out-out SNCooo out-out ActLoopNT-out 9.779 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -62.62, 116.57 APE9-dihe-na -76.67, -13.86 APE8-dihe-out -100.19, -102.3 APE8-rot-out 48.6 APE67-dihe-out -109.33, 135.36 -59.01, 126.17 APE12-dist-out 18.705 APE11-dist-out 17.881 APE10-dist-out 19.945 APE9-dist-out 14.473 None None None XRAY 2.6 0.169 0.215 A 328 289 31 0 0 0 [[68, 361]] 1.0 3mbl STE_MAP2K1_HUMAN STE 1.3e-97 332.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4ARKA Q02750 62 382 393.0 ADP:61383,M3K:61385 ATPlike,Type3 Inactive DFGin 6.213 13.32 BLBplus -143.7, -171.53 62.76, 23.96 -76.11, 159.51 42.79, 94.02 -85.45, 75.28 out-out out 15.353 Saltbr-out 15.901 HRD-in -67.47, -65.14 92.89, -4.81 out-out-out SNCooo out-out ActLoopNT-out 9.329 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -100.98, -15.83 APE9-dihe-na -32.88, 128.59 APE8-dihe-out -40.11, 20.06 APE8-rot-out 186.45 APE67-dihe-out -132.58, 138.09 -155.02, 124.88 APE12-dist-out 16.349 APE11-dist-out 18.139 APE10-dist-out 23.554 APE9-dist-out 14.426 None None None XRAY 2.6 0.174 0.211 A 341 290 31 0 0 0 [[68, 361]] 1.0 4ark STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3EQGA Q02750 39 381 393.0 ADP:2,4BM:1 ATPlike,Type3 Inactive DFGin 6.606 13.743 BLBplus -138.18, 179.2 59.31, 28.5 -81.55, 153.56 35.8, 92.23 -71.67, 64.14 out-out out 15.474 Saltbr-out 14.566 HRD-in -60.95, -65.33 94.63, -12.32 out-out-out SNCooo out-out ActLoopNT-out 9.231 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -104.38, 152.44 APE9-dihe-na -137.47, 114.08 APE8-dihe-in -13.21, 123.19 APE8-rot-out 216.51 APE67-dihe-in -71.17, -7.71 -101.04, 15.41 APE12-dist-out 19.79 APE11-dist-out 16.56 APE10-dist-out 18.855 APE9-dist-out 9.489 S298N,S299K,Y300F None None XRAY 2.5 0.21 0.273 A 360 314 29 0 0 0 [[68, 361]] 1.0 3eqg STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 6NYBB Q02750 56 383 393.0 ADP:60601,LCJ:60901 ATPlike,Type3 Inactive DFGin 5.959 14.037 BLBplus -152.28, 170.52 57.47, 42.76 -92.93, 161.49 47.46, 85.53 -88.41, 68.49 out-out out 15.47 Saltbr-out 17.602 HRD-in -56.15, -54.04 65.39, 11.35 out-out-out SNCooo out-out ActLoopNT-out 8.292 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -140.81, 127.27 APE9-dihe-na -93.66, 157.79 APE8-dihe-out -110.82, -26.16 APE8-rot-out 55.56 APE67-dihe-out -130.29, 148.43 -119.13, 133.87 APE12-dist-out 17.78 APE11-dist-out 18.319 APE10-dist-out 22.379 APE9-dist-out 12.159 S218A,S222A None None EM 4.1 999.0 999.0 B 415 289 39 0 0 0 [[68, 361]] 1.0 6nyb STE_MAP2K1_HUMAN STE 1.3e-96 329.0 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3EQHA Q02750 39 381 393.0 5BM:1,ADP:2 Type3,ATPlike Inactive DFGin 6.846 13.348 BLBplus -141.56, 168.5 59.76, 36.07 -79.95, 154.58 28.74, 98.71 -78.77, 88.92 out-out out 15.25 Saltbr-out 13.926 HRD-in -70.86, -51.49 82.66, -16.34 out-out-out SNCooo out-out ActLoopNT-out 9.845 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na 72.18, 69.91 APE9-dihe-na -156.93, 105.03 APE8-dihe-in -35.31, 137.66 APE8-rot-out 209.36 APE67-dihe-in -58.22, -17.3 -105.41, 1.3 APE12-dist-out 17.889 APE11-dist-out 18.024 APE10-dist-out 19.276 APE9-dist-out 9.655 S298N,S299K,Y300F None None XRAY 2.0 0.192 999.0 A 360 314 29 0 0 0 [[68, 361]] 1.0 3eqh STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE PAK3 PAK3_HUMAN 6FD3A O75914 261 556 559.0 ADP:60603 ATPlike Active DFGin 5.952 14.149 BLAminus -133.62, -174.01 64.9, 77.07 -96.85, 18.52 289.09, 83.73 -72.71, -11.5 in-in in 8.938 Saltbr-in 2.761 HRD-in -71.32, -50.63 74.19, 1.63 in-in-in SNCiii in-in ActLoopNT-in 2.913 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.75, 147.44 APE9-dihe-na 132.72, -161.48 APE8-dihe-in -114.41, 121.22 APE8-rot-in 305.33 APE67-dihe-in -64.48, -19.99 -44.4, -48.2 APE12-dist-in 8.849 APE11-dist-in 11.358 APE10-dist-in 5.576 APE9-dist-in 3.34 A537D None T8L436 XRAY 1.52 0.176 0.19 A 300 296 0 0 0 0 [[283, 534]] 1.0 6fd3 STE_PAK3_HUMAN STE 1.1e-94 322.5 1 257 257 419 420 421 423 425 312 328 332 399 401 400 402 459 447 442 441 440 439 438 437 436 358 Serine/threonine-protein kinase PAK 3
STE STK24 STK24_HUMAN 3A7JA Q9Y6E0 25 311 443.0 ADP:60500 ATPlike Active DFGin 6.747 14.583 BLAminus -138.67, 168.25 71.5, 79.52 -101.19, 20.06 287.01, 95.64 -64.31, -27.68 in-in in 8.53 Saltbr-in 2.552 HRD-in -69.86, -43.49 67.32, -1.05 in-in-in SNCiii in-in ActLoopNT-in 2.741 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.28, 158.62 APE9-dihe-na 130.53, -164.99 APE8-dihe-in -116.23, 120.86 APE8-rot-in 304.02 APE67-dihe-in -60.63, -23.79 -34.15, -55.13 APE12-dist-in 8.296 APE11-dist-in 11.11 APE10-dist-in 5.251 APE9-dist-in 3.288 None TPO190 TPO190 XRAY 1.5 0.191 0.21 A 303 287 0 0 0 0 [[36, 286]] 1.0 3a7j STE_STK24_HUMAN STE 3.6e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4O27B Q9Y6E0 30 309 443.0 ADP:60500 ATPlike Inactive DFGin 4.867 13.82 None -148.38, -173.28 56.25, -124.14 31.74, 82.19 64.76, 101.5 98.89, -78.6 in-in in 8.937 Saltbr-in 2.901 HRD-in -80.55, -48.63 69.48, -10.03 in-in-out SNCiio in-out ActLoopNT-in 3.017 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -123.0, 177.15 APE9-dihe-na 103.58, 170.34 APE8-dihe-in -99.19, 143.02 APE8-rot-out 34.53 APE67-dihe-in -72.39, -25.42 -54.44, -42.62 APE12-dist-in 9.028 APE11-dist-in 10.879 APE10-dist-in 5.562 APE9-dist-in 3.644 T190E None None XRAY 3.185 0.203 0.26 B 281 280 0 0 0 0 [[36, 286]] 1.0 4o27 STE_STK24_HUMAN STE 5.5e-100 339.9 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STRADA STRAA_HUMAN 8VSUB Q7RTN6 60 401 431.0 ADP:2001 ATPlike Pseudo DFGin 5.328 13.743 None -141.72, 9.36 -84.56, 30.72 -65.1, -14.12 305.81, 3.72 -62.58, -31.2 out-none out 10.229 Saltbr-none 999.0 HRD-out -66.66, 151.23 -136.62, 153.73 none-in-out SNCnio in-out ActLoopNT-in 2.866 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_iooo APE10-dihe-na -55.51, -37.77 APE9-dihe-na -75.16, -6.37 APE8-dihe-out -108.58, -14.7 APE8-rot-na 180.94 APE67-dihe-in -58.61, -34.89 -50.23, -38.37 APE12-dist-in 8.342 APE11-dist-out 7.821 APE10-dist-out 13.057 APE9-dist-out 11.052 None None None EM 2.86 999.0 999.0 B 429 306 36 0 0 0 [[69, 379]] 1.0 8vsu STE_STRADA_HUMAN STE 6.5e-87 297.3 1 257 257 212 213 214 216 218 100 118 122 192 194 193 195 261 247 242 241 240 239 238 237 236 148 STE20-related kinase adapter protein alpha
STE TAOK3 TAOK3_HUMAN 6BDNA Q9H2K8 8 314 898.0 ADP:404 ATPlike Active DFGin 6.771 13.825 BLAminus -136.73, -179.28 62.01, 80.15 -97.31, 23.85 293.38, 102.08 -68.85, -11.35 in-in in 8.485 Saltbr-in 2.682 HRD-in -74.02, -52.69 74.7, -5.2 in-in-in SNCiii in-in ActLoopNT-in 2.797 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.94, 158.28 APE9-dihe-na 130.64, -172.75 APE8-dihe-in -113.55, 120.19 APE8-rot-in 301.22 APE67-dihe-in -62.99, -26.26 -46.03, -46.8 APE12-dist-in 8.28 APE11-dist-in 11.04 APE10-dist-in 5.18 APE9-dist-in 3.383 R2A,K3A None None XRAY 1.5 0.187 0.214 A 320 307 0 0 0 0 [[24, 277]] 1.0 6bdn STE_TAOK3_HUMAN STE 6.3e-90 307.0 4 257 254 164 165 166 168 170 53 72 76 144 146 145 147 203 188 183 182 181 180 179 178 177 102 Serine/threonine-protein kinase TAO3
TKL BMPR2 BMPR2_HUMAN 3G2FA Q13873 197 510 1038.0 ADP:900 ATPlike Active DFGin 6.957 13.944 BLAminus -131.62, -179.2 66.08, 79.87 -102.79, 27.43 304.26, 96.52 -59.99, -25.3 in-in in 8.107 Saltbr-in 2.757 HRD-in -69.81, -50.66 82.19, -10.63 in-in-in SNCiii in-in ActLoopNT-in 2.981 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.1, -22.11 APE9-dihe-na -73.96, -168.61 APE8-dihe-in -80.16, 127.03 APE8-rot-in 308.56 APE67-dihe-in -65.91, -22.58 -59.75, -41.5 APE12-dist-in 11.403 APE11-dist-in 12.63 APE10-dist-in 7.026 APE9-dist-in 4.033 None None CAS288,CAS397,CAS496 XRAY 2.35 0.21 0.246 A 336 305 9 0 0 9 [[202, 503]] 1.0 3g2f TKL_BMPR2_HUMAN TKL 1.4e-75 260.2 2 266 265 350 351 352 354 356 230 243 247 330 332 331 333 405 386 381 380 379 378 377 376 375 280 Bone morphogenetic protein receptor type-2
TKL BMPR2 BMPR2_HUMAN 3G2FB Q13873 198 513 1038.0 ADP:900 ATPlike Active DFGin 6.968 14.008 BLAminus -149.7, 179.95 61.07, 87.18 -102.54, 11.93 293.8, 112.47 -56.7, -17.91 in-in in 8.065 Saltbr-in 2.732 HRD-in -73.22, -52.25 87.7, -10.0 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.94, -26.41 APE9-dihe-na -71.73, -175.39 APE8-dihe-in -71.07, 133.08 APE8-rot-in 315.55 APE67-dihe-in -68.07, -13.93 -56.75, -42.89 APE12-dist-in 11.194 APE11-dist-in 12.108 APE10-dist-in 6.494 APE9-dist-in 3.722 None None CAS288,CAS397,CAS496 XRAY 2.35 0.21 0.246 B 336 303 13 0 0 13 [[202, 503]] 1.0 3g2f TKL_BMPR2_HUMAN TKL 1.4e-75 260.2 2 266 265 350 351 352 354 356 230 243 247 330 332 331 333 405 386 381 380 379 378 377 376 375 280 Bone morphogenetic protein receptor type-2
TKL BMPR2 BMPR2_HUMAN 6UNPB Q13873 197 509 1038.0 ADP:601 ATPlike Active DFGin 6.917 14.051 BLAminus -140.56, 176.5 63.35, 76.41 -96.26, 25.8 302.12, 104.12 -61.08, -20.73 in-in in 7.904 Saltbr-in 2.865 HRD-in -75.95, -48.17 78.17, -6.91 in-in-in SNCiii in-in ActLoopNT-in 2.977 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.29, -9.38 APE9-dihe-na -69.43, -161.26 APE8-dihe-in -89.59, 127.34 APE8-rot-in 301.19 APE67-dihe-in -48.39, -33.11 -62.11, -43.63 APE12-dist-in 12.009 APE11-dist-in 12.508 APE10-dist-in 7.099 APE9-dist-in 4.016 D485G None CAS288,CAS397,CAS496 XRAY 2.3 0.19 0.211 B 363 303 10 0 0 8 [[202, 503]] 1.0 6unp TKL_BMPR2_HUMAN TKL 1.1e-74 257.3 2 266 265 350 351 352 354 356 230 243 247 330 332 331 333 405 386 381 380 379 378 377 376 375 280 Bone morphogenetic protein receptor type-2
TKL BMPR2 BMPR2_HUMAN 6UNPA Q13873 199 509 1038.0 ADP:601,ADP:602 ATPlike,Allosteric None DFGin 7.015 14.066 BLAminus -140.5, 177.86 62.51, 75.21 -94.82, 26.77 301.08, 104.11 -62.66, -20.97 in-in in 7.983 Saltbr-in 2.832 HRD-in -73.31, -49.03 80.8, -8.07 in-in-none SNCiin in-none ActLoopNT-in 2.92 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -134.35, -10.44 APE9-dihe-na -70.57, -158.87 APE8-dihe-in -91.29, 127.64 APE8-rot-in 299.54 APE67-dihe-in -49.77, -33.71 -61.84, -45.11 APE12-dist-none 999.0 APE11-dist-in 12.741 APE10-dist-in 7.284 APE9-dist-in 4.093 D485G None CAS288,CAS397,CAS496 XRAY 2.3 0.19 0.211 A 363 302 9 0 0 9 [[202, 503]] 1.0 6unp TKL_BMPR2_HUMAN TKL 1.1e-74 257.3 2 266 265 350 351 352 354 356 230 243 247 330 332 331 333 405 386 381 380 379 378 377 376 375 280 Bone morphogenetic protein receptor type-2
TKL KSR2 KSR2_HUMAN 7JUQB Q6VAB6 652 932 950.0 ADP:1001 ATPlike Pseudo DFGin 5.723 13.43 BLBplus -139.35, 152.22 61.66, 33.54 -71.04, 141.2 52.07, 82.92 82.4, -21.94 out-none out 15.389 Saltbr-none 999.0 HRD-in -71.47, -51.16 73.41, 1.02 none-out-out SNCnoo out-out ActLoopNT-out 7.459 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -57.45, -45.23 APE9-dihe-na -90.48, -7.37 APE8-dihe-out -66.85, -54.6 APE8-rot-na 183.3 APE67-dihe-in -71.76, -8.04 -52.06, -44.72 APE12-dist-out 18.487 APE11-dist-out 15.103 APE10-dist-out 19.519 APE9-dist-out 11.963 None None None XRAY 3.22 0.256 0.288 B 342 277 4 0 0 3 [[665, 930]] 1.0 7juq TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TYR ABL1 ABL1_HUMAN 2G2IA P00519 229 502 1130.0 ADP:820 ATPlike Inactive DFGin 6.631 13.433 BLAminus -148.4, 173.75 80.3, 76.24 -98.47, 37.85 308.34, 118.79 -64.97, -55.29 in-in in 8.005 Saltbr-in 3.247 HRD-out -103.94, 83.88 -55.25, 17.72 in-in-in SNCiii in-in ActLoopNT-in 3.064 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -140.34, 116.79 APE9-dihe-in -127.46, 160.87 APE8-dihe-in -56.61, 91.87 APE8-rot-na 28.18 APE67-dihe-in -56.4, -10.87 -40.77, -65.33 APE12-dist-na 14.904 APE11-dist-na 10.573 APE10-dist-na 12.836 APE9-dist-in 7.31 H396P None None XRAY 3.12 0.251 0.308 A 287 271 3 0 0 0 [[242, 495]] 1.0 2g2i TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2G2IB P00519 232 500 1130.0 ADP:821 ATPlike Inactive DFGin 6.623 13.745 BLAminus -144.73, -170.13 58.63, 49.5 -73.16, 23.66 306.98, 113.05 -58.19, -50.38 in-in in 7.795 Saltbr-in 2.872 HRD-out -111.21, 97.67 -66.16, -14.66 in-in-in SNCiii in-in ActLoopNT-in 3.404 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.86, 132.09 APE9-dihe-in -111.79, 159.65 APE8-dihe-in -83.23, 82.29 APE8-rot-na 32.48 APE67-dihe-in -53.07, -28.27 -29.82, -59.17 APE12-dist-na 14.975 APE11-dist-na 10.34 APE10-dist-na 12.829 APE9-dist-in 7.625 H396P None None XRAY 3.12 0.251 0.308 B 287 265 4 0 0 0 [[242, 495]] 1.0 2g2i TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ALK ALK_HUMAN 3LCTA Q9UM73 1093 1400 1620.0 ADP:1412 ATPlike Inactive DFGin 6.266 15.193 ABAminus -127.22, 10.26 -136.37, 129.73 -130.23, 18.7 291.41, 88.16 -49.74, -46.74 in-none in 8.1 Saltbr-none 999.0 HRD-in -78.72, -45.58 81.21, -3.39 none-out-out SNCnoo out-out ActLoopNT-out 6.886 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -94.62, -10.42 APE9-dihe-in -67.88, 140.77 APE8-dihe-in -81.63, 62.42 APE8-rot-na 34.08 APE67-dihe-in -66.16, -16.53 -61.79, -27.56 APE12-dist-na 14.739 APE11-dist-na 15.112 APE10-dist-na 9.981 APE9-dist-out 8.031 S1281G None None XRAY 2.1 0.207 0.255 A 344 308 0 0 0 0 [[1116, 1385]] 1.0 3lct TYR_ALK_HUMAN TYR 5e-90 307.3 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR EGFR EGFR_HUMAN 4RIWB P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.947 14.509 None -144.94, -140.84 60.54, -94.56 67.75, 16.38 293.55, 125.63 -72.75, -24.64 in-in in 8.962 Saltbr-in 2.577 HRD-out -81.5, 87.13 -71.92, 10.44 in-in-none SNCiin in-none ActLoopNT-in 2.914 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.11 APE8-dihe-in -64.72, 105.47 APE8-rot-na 338.81 APE67-dihe-in -78.09, 0.73 -66.98, -35.92 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.339 V948R,F997A,L1001A None None XRAY 3.1 0.233 0.287 B 345 293 4 0 0 4 [[712, 970]] 1.0 4riw TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIWD P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 6.016 14.399 None -147.43, -141.55 60.24, -94.38 68.1, 17.38 294.17, 126.48 -72.23, -23.22 in-in in 8.845 Saltbr-in 3.081 HRD-in -78.23, -46.1 60.09, 5.38 in-in-in SNCiii in-in ActLoopNT-in 2.84 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.64, 111.47 APE9-dihe-in -129.74, 134.09 APE8-dihe-in -62.84, 106.17 APE8-rot-na 337.89 APE67-dihe-in -78.37, 3.33 -65.15, -34.97 APE12-dist-na 11.397 APE11-dist-na 9.946 APE10-dist-na 9.723 APE9-dist-in 6.015 V948R,F997A,L1001A None None XRAY 3.1 0.233 0.287 D 345 297 0 0 0 0 [[712, 970]] 1.0 4riw TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIXB P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.919 14.579 None -139.87, -153.46 71.8, -106.42 74.55, 12.91 300.13, 117.16 -73.01, -18.89 in-in in 8.778 Saltbr-in 2.851 HRD-out -79.93, 91.22 -73.37, 9.67 in-in-none SNCiin in-none ActLoopNT-in 2.815 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.04 APE8-dihe-in -57.54, 105.82 APE8-rot-na 336.15 APE67-dihe-in -83.65, 5.55 -71.82, -34.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.644 V948R,F997A,L1001A None None XRAY 3.1 0.21 0.258 B 345 293 4 0 0 4 [[712, 970]] 1.0 4rix TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIXD P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.984 14.396 None -138.76, -155.76 70.86, -102.17 73.98, 14.44 299.1, 114.44 -71.0, -18.03 in-in in 8.433 Saltbr-in 2.13 HRD-in -75.74, -46.31 59.89, 5.04 in-in-in SNCiii in-in ActLoopNT-in 2.879 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.43, 115.77 APE9-dihe-in -128.43, 136.25 APE8-dihe-in -57.6, 106.59 APE8-rot-na 335.5 APE67-dihe-in -81.04, 4.3 -70.58, -32.32 APE12-dist-na 11.336 APE11-dist-na 10.144 APE10-dist-na 10.428 APE9-dist-in 5.987 V948R,F997A,L1001A None None XRAY 3.1 0.21 0.258 D 345 297 0 0 0 0 [[712, 970]] 1.0 4rix TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIYB P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.952 14.655 None -154.99, 131.23 -173.19, -76.87 64.96, 12.46 300.69, 132.23 -71.94, -28.32 in-in in 8.685 Saltbr-in 2.95 HRD-out -79.99, 96.69 -77.78, 9.7 in-in-none SNCiin in-none ActLoopNT-in 2.884 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.59 APE8-dihe-in -76.15, 93.2 APE8-rot-na 346.43 APE67-dihe-in -79.33, 6.83 -64.49, -46.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.35 V948R,F997A,L1001A None None XRAY 2.981 0.221 0.267 B 345 293 4 0 0 4 [[712, 970]] 1.0 4riy TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIYD P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.892 14.398 None -146.72, -160.68 90.34, -82.61 63.94, 14.36 297.22, 112.71 -69.53, -27.12 in-in in 8.333 Saltbr-in 2.327 HRD-in -73.91, -45.57 61.02, 4.8 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.34, 113.28 APE9-dihe-in -130.38, 137.58 APE8-dihe-in -69.37, 99.85 APE8-rot-na 344.82 APE67-dihe-in -75.56, 6.57 -58.1, -42.52 APE12-dist-na 11.232 APE11-dist-na 10.201 APE10-dist-na 9.961 APE9-dist-in 6.258 V948R,F997A,L1001A None None XRAY 2.981 0.221 0.267 D 345 297 0 0 0 0 [[712, 970]] 1.0 4riy TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EPHB1 EPHB1_HUMAN 7KPMA P54762 611 888 984.0 ADP:901 ATPlike Inactive DFGin 6.148 15.077 None -129.01, -161.15 68.81, 56.56 -103.91, 999.0 293.32, 103.77 999.0, 999.0 in-in in 7.744 Saltbr-in 2.709 HRD-in -77.02, -45.59 75.58, -13.35 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 76.94 APE8-rot-na 30.04 APE67-dihe-in -77.93, -6.39 -53.89, -41.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None PTR647 PTR647 XRAY 1.608 0.169 0.197 A 279 255 23 0 0 23 [[619, 880]] 1.0 7kpm TYR_EPHB1_HUMAN TYR 2.3e-109 370.6 2 261 260 761 762 763 765 767 651 668 672 741 743 742 744 806 794 789 788 787 786 785 784 783 698 Ephrin type-B receptor 1
TYR ITK ITK_HUMAN 4M15A Q08881 355 617 620.0 QWS:701,ADP:702 Type3,ATPlike Inactive DFGin 7.939 15.29 BLBplus -140.12, 163.53 73.68, 16.28 -64.43, 134.2 34.87, 95.02 79.06, -6.9 out-out out 17.066 Saltbr-out 16.254 HRD-in -70.42, -53.15 83.67, -22.02 out-out-out SNCooo out-out ActLoopNT-out 7.74 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -106.59, 12.56 APE9-dihe-in -62.84, 135.73 APE8-dihe-in -75.4, 60.83 APE8-rot-na 30.68 APE67-dihe-in -61.26, -23.89 -55.9, -32.96 APE12-dist-na 16.836 APE11-dist-na 19.515 APE10-dist-na 14.784 APE9-dist-out 9.152 None None None XRAY 1.52 0.172 0.186 A 269 263 0 0 0 0 [[363, 614]] 1.0 4m15 TYR_ITK_HUMAN TYR 1.2e-92 315.8 1 260 260 499 500 501 503 505 391 406 410 479 481 480 482 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR JAK1-2 JAK1_HUMAN 5KHWA P23458 867 1153 1154.0 ADP:1201 ATPlike Inactive DFGin 6.293 13.595 ABAminus -113.62, -36.19 -113.51, 112.49 -104.48, 28.51 302.05, 98.46 -68.45, -35.55 in-in in 8.017 Saltbr-in 2.811 HRD-in -53.69, -54.55 74.32, 4.71 in-in-in SNCiii in-in ActLoopNT-in 2.817 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.25, 151.86 APE9-dihe-in -139.19, 145.92 APE8-dihe-in -78.07, 75.73 APE8-rot-na 29.65 APE67-dihe-in -77.72, -3.4 -55.44, -31.5 APE12-dist-na 13.014 APE11-dist-na 7.332 APE10-dist-na 9.905 APE9-dist-in 6.022 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.47 0.188 0.231 A 316 278 9 0 0 0 [[583, 847], [875, 1151]] 2.0 5khw TYR_JAK1-2_HUMAN TYR 2.6e-87 298.4 2 259 258 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
TYR JAK1-2 JAK1_HUMAN 6C7YA P23458 869 1153 1154.0 ADP:61201 ATPlike Active DFGin 6.032 13.967 BLAminus -134.15, -164.18 58.49, 84.96 -109.28, 28.04 298.78, 97.45 -66.39, -27.05 in-in in 8.311 Saltbr-in 2.732 HRD-in -67.59, -46.53 68.25, 12.43 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.91, 151.36 APE9-dihe-in -137.76, 143.32 APE8-dihe-in -74.71, 81.76 APE8-rot-na 30.49 APE67-dihe-in -79.4, -2.38 -65.2, -24.66 APE12-dist-na 12.972 APE11-dist-na 8.02 APE10-dist-na 10.344 APE9-dist-in 6.316 None PTR1035 PTR1035 XRAY 2.499 0.21 0.241 A 286 273 12 0 0 0 [[583, 847], [875, 1151]] 2.0 6c7y TYR_JAK1-2_HUMAN TYR 1.8e-87 298.9 2 259 258 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
TYR JAK1-2 JAK1_HUMAN 5KHWB P23458 867 1153 1154.0 ADP:1201 ATPlike Inactive DFGin 6.188 13.787 BLAminus -126.62, -174.05 50.66, 92.23 -105.71, 28.99 301.42, 97.18 -62.73, -33.32 in-in in 7.991 Saltbr-in 2.817 HRD-in -54.38, -55.02 75.74, 4.0 in-in-out SNCiio in-out ActLoopNT-in 2.811 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -83.14, 18.97 APE9-dihe-in -58.32, 113.18 APE8-dihe-in -82.04, 77.86 APE8-rot-na 28.29 APE67-dihe-in -76.85, -3.42 -56.14, -32.61 APE12-dist-na 7.879 APE11-dist-na 9.695 APE10-dist-na 6.605 APE9-dist-in 5.912 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.47 0.188 0.231 B 316 278 9 0 0 0 [[583, 847], [875, 1151]] 2.0 5khw TYR_JAK1-2_HUMAN TYR 2.6e-87 298.4 2 259 258 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
TYR KIT KIT_HUMAN 1PKGA P10721 567 927 976.0 ADP:1480 ATPlike Inactive DFGin 6.481 14.136 BLAminus -130.56, -161.98 47.26, 79.76 -98.59, 34.29 290.92, 88.36 -71.71, -28.0 in-out in 8.138 Saltbr-out 3.883 HRD-in -70.61, -44.29 71.47, -6.33 out-in-out SNCoio in-out ActLoopNT-in 2.981 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 81.05, 87.98 APE9-dihe-in -123.34, 167.37 APE8-dihe-in -84.87, 64.98 APE8-rot-na 27.08 APE67-dihe-in -64.22, -13.25 -46.84, -45.75 APE12-dist-na 14.817 APE11-dist-na 9.099 APE10-dist-na 11.173 APE9-dist-in 6.894 None PTR568,PTR570 PTR568,PTR570 XRAY 2.9 0.229 0.311 A 329 292 11 0 0 0 [[589, 926]] 1.0 1pkg TYR_KIT_HUMAN TYR 4.5e-102 346.9 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 1PKGB P10721 566 929 976.0 ADP:1486 ATPlike None DFGin 6.537 13.819 BLAminus -133.94, -165.75 57.9, 93.59 -119.64, 36.22 290.23, 87.19 -80.39, -20.36 in-in in 6.934 Saltbr-in 2.915 HRD-in -72.14, -51.55 69.69, 17.19 in-in-none SNCiin in-none ActLoopNT-in 2.888 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 110.55 APE9-dihe-in -141.29, 162.93 APE8-dihe-in -80.26, 78.25 APE8-rot-na 29.66 APE67-dihe-in -62.74, -24.13 -40.98, -43.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.765 APE9-dist-in 6.494 None PTR568,PTR570 PTR568,PTR570 XRAY 2.9 0.229 0.311 B 329 279 27 0 0 13 [[589, 926]] 1.0 1pkg TYR_KIT_HUMAN TYR 4.5e-102 346.9 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR MERTK MERTK_HUMAN 3BRBA Q12866 575 861 999.0 ADP:901 ATPlike Inactive DFGin 6.074 13.609 BLBplus -149.4, 172.79 64.51, 33.37 -100.26, 164.7 46.71, 83.96 59.32, 174.03 out-out out 13.75 Saltbr-out 12.558 HRD-in -82.25, -54.47 71.68, 7.51 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -42.31 APE8-dihe-in -85.78, 61.15 APE8-rot-na 26.09 APE67-dihe-in -74.59, -1.92 -45.39, -40.65 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.341 None None None XRAY 1.9 0.195 0.24 A 313 260 27 0 0 16 [[587, 856]] 1.0 3brb TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 3BRBB Q12866 575 863 999.0 ADP:901 ATPlike Inactive DFGin 5.874 13.373 BLBplus -148.45, 175.8 65.39, 30.29 -97.01, 161.01 52.76, 80.7 77.95, 168.41 out-out out 13.696 Saltbr-out 12.572 HRD-in -83.14, -55.33 72.79, 2.25 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.74 APE8-rot-na 30.57 APE67-dihe-in -72.04, -6.33 -47.66, -41.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.195 0.24 B 313 271 18 0 0 18 [[587, 856]] 1.0 3brb TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR PTK2 FAK1_HUMAN 2IJMB Q05397 414 689 1052.0 ADP:800 ATPlike Inactive DFGin 6.323 15.493 BLBminus -110.71, -163.98 67.21, 81.0 -117.82, 145.96 283.77, 97.43 -64.08, -51.52 in-out in 7.648 Saltbr-out 3.676 HRD-in -77.75, -52.2 82.75, -4.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -36.05 APE8-dihe-out -75.82, 46.85 APE8-rot-na 30.48 APE67-dihe-in -72.2, -5.65 -47.65, -46.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.699 None None None XRAY 2.187 0.211 0.271 B 281 261 15 0 0 15 [[422, 678]] 1.0 2ijm TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 1MP8A Q05397 414 686 1052.0 ADP:800 ATPlike Inactive None 999.0 999.0 None -89.07, -172.44 90.39, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 7.446 Saltbr-in 3.097 HRD-in -74.41, -44.19 70.37, -1.26 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.38 APE8-dihe-in -79.05, 61.98 APE8-rot-na 29.35 APE67-dihe-in -62.59, -13.79 -46.47, -46.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.07 None None None XRAY 1.6 0.188 0.23 A 281 252 21 0 0 19 [[422, 678]] 1.0 1mp8 TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR TYK2-2 TYK2_HUMAN 4GVJA P29597 889 1176 1187.0 ADP:61201 ATPlike Inactive DFGin 6.265 13.752 BLAminus -124.99, -169.67 58.4, 84.34 -100.6, 24.1 294.23, 90.13 -57.35, -28.35 in-in in 8.284 Saltbr-in 2.699 HRD-in -78.85, -48.62 71.47, -0.89 in-in-out SNCiio in-out ActLoopNT-in 2.842 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -90.25, 6.85 APE9-dihe-in -64.48, 128.39 APE8-dihe-in -76.05, 68.17 APE8-rot-na 27.93 APE67-dihe-in -72.65, -6.35 -49.95, -35.24 APE12-dist-na 9.968 APE11-dist-na 13.036 APE10-dist-na 9.649 APE9-dist-in 6.845 C936A,Q969A,E971A,K972A,C1142A None None XRAY 2.03 0.19 0.231 A 302 288 0 0 0 0 [[589, 868], [897, 1171]] 2.0 4gvj TYR_TYK2-2_HUMAN TYR 9.4e-82 280.2 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2

Ligand: ADP

Total number of chains: 318
Active chains: 117
Total number of genes: 77
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 239 75.2% 6YZHA
DFGin BLBplus 31 9.7% 4M15A
DFGin None 17 5.3% 5GZAA
DFGin ABAminus 11 3.5% 3LCTA
None None 11 3.5% 4IX4A
DFGin BLBminus 5 1.6% 5M06B
DFGinter None 4 1.3% 5L8LA
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL BRI1 BRI1_ARATH 5LPBA O22476 867 1160 1196.0 ADP:1201 ATPlike Active DFGin 5.075 15.058 BLAminus -134.68, 179.03 63.17, 81.59 -99.15, 20.06 285.86, 73.26 -60.78, -23.17 in-in in 8.649 Saltbr-in 3.148 HRD-in -69.16, -46.8 71.42, -2.74 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -107.78, 147.47 APE9-dihe-na 145.38, -170.04 APE8-dihe-in -133.78, 133.64 APE8-rot-in 306.07 APE67-dihe-inflip 102.35, -15.45 -46.22, 126.04 APE12-dist-in 9.248 APE11-dist-in 11.275 APE10-dist-in 5.497 APE9-dist-in 3.743 T872A TPO1039,SEP1042,SEP1044,SEP1060 TPO1039,SEP1042,SEP1044,SEP1060 XRAY 1.98 0.184 0.203 A 296 284 10 0 0 0 [[882, 1157]] 1.0 5lpb Arabidopsis thaliana TKL_BRI1_ARATH TKL 2e-63 220.4 4 266 263 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL BRI1 BRI1_ARATH 5LPZA O22476 866 1160 1196.0 ADP:1200 ATPlike Active DFGin 5.281 15.229 BLAminus -133.61, -178.19 59.45, 71.09 -88.15, 19.11 288.53, 76.38 -60.79, -23.86 in-in in 8.633 Saltbr-in 2.829 HRD-in -68.17, -37.55 64.9, -2.92 in-in-in SNCiii in-in ActLoopNT-in 3.022 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -69.74, 170.98 APE9-dihe-na 106.33, 162.6 APE8-dihe-in -102.72, 137.46 APE8-rot-in 305.68 APE67-dihe-inflip 102.78, -18.56 -57.05, 134.59 APE12-dist-in 9.342 APE11-dist-in 11.755 APE10-dist-in 5.72 APE9-dist-in 3.579 T872A TPO1039,SEP1042,SEP1044 TPO1039,SEP1042,SEP1044 XRAY 2.48 0.226 0.253 A 332 286 9 0 0 0 [[882, 1157]] 1.0 5lpz Arabidopsis thaliana TKL_BRI1_ARATH TKL 3e-63 219.9 4 266 263 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL FERONIA FERON_ARATH 7XDXA Q9SCZ4 521 815 895.0 ADP:901 ATPlike Inactive DFGin 6.868 15.508 BLAminus -133.42, -178.74 67.64, 77.46 -97.26, 15.76 285.98, 88.34 -59.81, -31.94 in-out in 8.722 Saltbr-out 5.533 HRD-in -65.25, -47.87 74.08, 0.6 out-in-none SNCoin in-none ActLoopNT-in 2.762 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 135.64 APE8-rot-in 306.33 APE67-dihe-inflip 94.97, -23.67 -64.5, 138.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.23 0.184 0.235 A 313 280 15 0 0 15 [[535, 809]] 1.0 7xdx Arabidopsis thaliana TKL_FERONIA_ARATH TKL 2e-57 200.7 3 266 264 678 679 680 682 684 565 581 585 658 660 659 661 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
TKL FERONIA FERON_ARATH 7XDXB Q9SCZ4 521 815 895.0 ADP:901 ATPlike None DFGin 6.622 15.425 BLAminus -136.76, -177.06 63.7, 79.87 -96.73, 14.62 285.92, 71.87 -59.53, -21.5 in-in in 8.576 Saltbr-in 3.332 HRD-in -65.1, -49.82 75.49, 1.86 in-in-none SNCiin in-none ActLoopNT-in 2.737 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 136.01 APE8-rot-in 320.81 APE67-dihe-inflip 95.62, -22.56 -64.49, 139.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.23 0.184 0.235 B 313 280 15 0 0 15 [[535, 809]] 1.0 7xdx Arabidopsis thaliana TKL_FERONIA_ARATH TKL 2e-57 200.7 3 266 264 678 679 680 682 684 565 581 585 658 660 659 661 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
TKL FERONIA FERON_ARATH 7XDYA Q9SCZ4 521 815 895.0 ADP:901 ATPlike Inactive DFGin 6.759 15.786 BLAminus -141.78, -171.91 66.87, 59.86 -83.38, 11.19 284.91, 77.98 -59.88, -27.32 in-out in 8.886 Saltbr-out 5.604 HRD-in -63.61, -43.27 68.91, 0.58 out-in-none SNCoin in-none ActLoopNT-in 2.863 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 155.73 APE8-rot-in 307.09 APE67-dihe-inflip 97.81, -22.04 -77.29, 136.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.28 0.2 0.247 A 313 280 15 0 0 15 [[535, 809]] 1.0 7xdy Arabidopsis thaliana TKL_FERONIA_ARATH TKL 2e-57 200.7 3 266 264 678 679 680 682 684 565 581 585 658 660 659 661 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
TKL FERONIA FERON_ARATH 7XDYB Q9SCZ4 522 816 895.0 ADP:901 ATPlike Inactive DFGin 6.449 16.033 BLAminus -144.23, -178.13 65.87, 74.19 -94.93, 27.11 292.01, 67.35 -65.38, -32.71 in-out in 9.349 Saltbr-out 6.079 HRD-in -72.36, -52.52 79.98, -11.0 out-in-out SNCoio in-out ActLoopNT-in 2.784 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -15.92 APE8-rot-out 172.5 APE67-dihe-in -79.26, 18.24 -58.71, -66.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.28 0.2 0.247 B 313 280 15 0 0 15 [[535, 809]] 1.0 7xdy Arabidopsis thaliana TKL_FERONIA_ARATH TKL 2e-57 200.7 3 266 264 678 679 680 682 684 565 581 585 658 660 659 661 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
TKL FERONIA FERON_ARATH 7XDWA Q9SCZ4 521 815 895.0 ADP:901 ATPlike None DFGin 6.737 15.747 BLAminus -137.39, -174.63 58.35, 60.55 -84.66, 26.98 279.96, 82.38 -74.32, -25.62 in-none in 8.732 Saltbr-none 999.0 HRD-in -69.86, -44.55 71.98, 2.17 none-in-none SNCnin in-none ActLoopNT-in 2.918 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 144.08 APE8-rot-in 320.64 APE67-dihe-in -58.47, -9.87 -56.6, -62.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.926 0.188 0.207 A 313 281 14 0 0 14 [[535, 809]] 1.0 7xdw Arabidopsis thaliana TKL_FERONIA_ARATH TKL 8.2e-57 198.7 3 266 264 678 679 680 682 684 565 581 585 658 660 659 661 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
TKL FERONIA FERON_ARATH 7XDWB Q9SCZ4 522 816 895.0 ADP:901 ATPlike None DFGin 6.708 15.519 BLAminus -137.44, -171.65 65.06, 59.01 -87.27, 21.93 280.32, 83.86 -70.86, -24.01 in-none in 8.702 Saltbr-none 999.0 HRD-in -70.0, -44.65 71.38, 1.15 none-in-none SNCnin in-none ActLoopNT-in 2.944 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 146.34 APE8-rot-in 314.87 APE67-dihe-inflip 95.5, -19.53 -58.77, 130.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.926 0.188 0.207 B 313 281 14 0 0 14 [[535, 809]] 1.0 7xdw Arabidopsis thaliana TKL_FERONIA_ARATH TKL 8.2e-57 198.7 3 266 264 678 679 680 682 684 565 581 585 658 660 659 661 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
AGC GRK1 GRK1_BOVIN 3C4ZA P28327 31 533 561.0 ADP:562 ATPlike Active DFGin 5.913 13.235 BLAminus -149.46, 171.26 70.91, 78.39 -108.02, 16.47 270.55, 111.24 -69.43, -16.01 in-in in 8.736 Saltbr-in 2.716 HRD-in -71.08, -53.07 69.31, 6.53 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.53, 147.45 APE9-dihe-na 134.96, -165.72 APE8-dihe-in -111.39, 128.56 APE8-rot-in 296.58 APE67-dihe-inflip 96.79, -17.75 -54.96, 131.39 APE12-dist-in 10.43 APE11-dist-in 11.113 APE10-dist-in 5.49 APE9-dist-in 3.542 None None None XRAY 1.84 0.193 999.0 A 543 493 0 0 0 0 [[187, 452]] 1.0 3c4z Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C50A P28327 30 533 561.0 ADP:562 ATPlike Active DFGin 6.075 13.034 BLAminus -142.59, 172.43 68.85, 78.38 -104.12, 14.36 280.99, 104.76 -67.57, -15.07 in-in in 8.602 Saltbr-in 2.925 HRD-in -76.21, -52.36 64.46, 15.62 in-in-in SNCiii in-in ActLoopNT-in 2.795 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.66, 144.27 APE9-dihe-na 130.37, -165.26 APE8-dihe-in -104.68, 131.22 APE8-rot-in 300.48 APE67-dihe-inflip 92.29, -6.18 -56.88, 135.03 APE12-dist-in 10.685 APE11-dist-in 11.469 APE10-dist-in 5.876 APE9-dist-in 3.473 None None None XRAY 2.6 0.19 999.0 A 543 499 0 0 0 0 [[187, 452]] 1.0 3c50 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C50B P28327 30 533 561.0 ADP:562 ATPlike Active DFGin 6.078 13.068 BLAminus -140.52, 175.4 66.53, 77.05 -104.14, 18.55 279.39, 103.87 -67.23, -21.39 in-in in 8.532 Saltbr-in 2.721 HRD-in -71.74, -52.34 63.89, 11.32 in-in-in SNCiii in-in ActLoopNT-in 2.89 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.47, 143.37 APE9-dihe-na 137.53, -168.17 APE8-dihe-in -105.39, 125.32 APE8-rot-in 297.12 APE67-dihe-inflip 95.82, -17.57 -51.32, 135.4 APE12-dist-in 10.129 APE11-dist-in 11.115 APE10-dist-in 5.538 APE9-dist-in 3.418 None None None XRAY 2.6 0.19 999.0 B 543 496 0 0 0 0 [[187, 452]] 1.0 3c50 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C51A P28327 31 533 561.0 ADP:562 ATPlike Active DFGin 5.735 13.235 BLAminus -156.28, 178.74 57.85, 73.51 -84.14, -2.01 283.03, 106.57 -47.35, -22.99 in-in in 8.798 Saltbr-in 2.687 HRD-in -64.41, -45.82 69.5, -19.46 in-in-in SNCiii in-in ActLoopNT-in 2.916 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -176.64, 142.5 APE9-dihe-na 155.52, -169.52 APE8-dihe-in -101.5, 135.25 APE8-rot-in 300.99 APE67-dihe-inflip 84.91, 4.53 -59.96, 128.0 APE12-dist-in 10.573 APE11-dist-in 11.541 APE10-dist-in 6.152 APE9-dist-in 3.937 None None None XRAY 3.55 0.281 999.0 A 543 487 0 0 0 0 [[187, 452]] 1.0 3c51 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C51B P28327 31 533 561.0 ADP:562 ATPlike Active DFGin 5.785 13.187 BLAminus -156.29, 175.57 58.57, 74.43 -85.29, -1.69 285.99, 107.07 -47.38, -22.91 in-in in 8.696 Saltbr-in 2.792 HRD-in -66.67, -42.5 63.68, -15.39 in-in-in SNCiii in-in ActLoopNT-in 2.969 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -176.05, 141.93 APE9-dihe-na 155.26, -171.96 APE8-dihe-in -101.33, 138.35 APE8-rot-in 299.85 APE67-dihe-inflip 84.6, 5.24 -64.39, 128.67 APE12-dist-in 10.537 APE11-dist-in 11.598 APE10-dist-in 6.156 APE9-dist-in 3.94 None None None XRAY 3.55 0.281 999.0 B 543 461 20 0 0 0 [[187, 452]] 1.0 3c51 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3QC9A P28327 31 533 561.0 ADP:700 ATPlike Active DFGin 6.852 13.484 BLAminus -151.04, 174.48 70.22, 99.25 -129.57, 18.73 275.22, 99.19 -61.63, -18.96 in-in in 8.961 Saltbr-in 3.127 HRD-in -61.98, -58.15 73.37, -3.42 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -167.32, 133.82 APE9-dihe-na 142.48, -169.15 APE8-dihe-in -104.33, 125.71 APE8-rot-in 302.67 APE67-dihe-inflip 104.42, -3.83 -50.74, 122.55 APE12-dist-in 10.356 APE11-dist-in 11.014 APE10-dist-in 5.5 APE9-dist-in 3.664 T8C,N480C None None XRAY 2.7 0.194 0.229 A 543 486 0 0 0 0 [[187, 452]] 1.0 3qc9 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3QC9B P28327 31 533 561.0 ADP:700 ATPlike Active DFGin 6.899 13.504 BLAminus -154.17, 173.67 70.5, 100.81 -132.54, 18.75 276.87, 97.69 -56.57, -24.02 in-in in 8.931 Saltbr-in 3.099 HRD-in -65.24, -58.34 73.4, -2.88 in-in-in SNCiii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -166.53, 132.45 APE9-dihe-na 145.72, -169.79 APE8-dihe-in -103.09, 126.5 APE8-rot-in 303.38 APE67-dihe-inflip 99.94, -4.73 -52.12, 123.93 APE12-dist-in 10.368 APE11-dist-in 11.038 APE10-dist-in 5.525 APE9-dist-in 3.677 T8C,N480C None None XRAY 2.7 0.194 0.229 B 543 481 0 0 0 0 [[187, 452]] 1.0 3qc9 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3QC9C P28327 31 533 561.0 ADP:700 ATPlike Active DFGin 6.868 13.481 BLAminus -151.87, 172.48 72.03, 98.62 -128.19, 19.72 276.34, 98.38 -59.47, -19.79 in-in in 8.951 Saltbr-in 3.107 HRD-in -62.09, -58.44 72.04, -1.68 in-in-in SNCiii in-in ActLoopNT-in 2.936 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -168.26, 134.05 APE9-dihe-na 142.83, -170.11 APE8-dihe-in -104.04, 126.58 APE8-rot-in 301.36 APE67-dihe-inflip 105.14, -2.81 -49.9, 120.73 APE12-dist-in 10.384 APE11-dist-in 11.018 APE10-dist-in 5.508 APE9-dist-in 3.673 T8C,N480C None None XRAY 2.7 0.194 0.229 C 543 482 0 0 0 0 [[187, 452]] 1.0 3qc9 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3QC9D P28327 31 533 561.0 ADP:700 ATPlike Active DFGin 6.923 13.517 BLAminus -151.29, 174.11 71.25, 99.27 -130.54, 20.81 276.77, 98.72 -58.99, -24.3 in-in in 8.931 Saltbr-in 3.091 HRD-in -63.44, -57.63 71.87, -0.43 in-in-in SNCiii in-in ActLoopNT-in 2.927 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.95, 134.69 APE9-dihe-na 141.2, -168.54 APE8-dihe-in -103.28, 126.55 APE8-rot-in 303.76 APE67-dihe-inflip 102.49, -2.5 -51.29, 121.62 APE12-dist-in 10.397 APE11-dist-in 11.044 APE10-dist-in 5.513 APE9-dist-in 3.693 T8C,N480C None None XRAY 2.7 0.194 0.229 D 543 486 0 0 0 0 [[187, 452]] 1.0 3qc9 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
CK1 HRR25 Q6FS46_CANGA 4XH0A Q6FS46 3 397 495.0 ADP:501 ATPlike None DFGin 6.443 15.383 BLAminus -128.64, -179.51 59.61, 77.98 -98.4, 10.06 283.06, 95.13 -55.51, -31.98 in-none in 8.149 Saltbr-none 999.0 HRD-in -77.95, -46.78 69.84, 1.34 none-in-in SNCnii in-in ActLoopNT-in 2.77 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.48, 125.7 APE9-dihe-na -118.27, -46.73 APE8-dihe-in -107.01, 112.94 APE8-rot-in 317.73 APE67-dihe-in -59.61, -42.11 -60.33, -32.21 APE12-dist-in 13.281 APE11-dist-in 12.522 APE10-dist-in 6.926 APE9-dist-in 5.2 K38R None None XRAY 1.99 0.168 0.2 A 403 350 5 0 0 0 [[9, 275]] 1.0 4xh0 Candida glabrata CK1_HRR25_CANGA CK1 2.6e-101 344.7 1 261 261 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 non-specific serine/threonine protein kinase
CK1 HRR25 Q6FS46_CANGA 4XHGA Q6FS46 2 397 495.0 ADP:501 ATPlike Inactive DFGin 6.768 15.524 BLAminus -126.45, -178.1 65.49, 74.25 -101.88, 16.36 285.39, 86.86 -58.89, -30.96 in-none in 8.237 Saltbr-none 999.0 HRD-in -77.78, -51.52 75.28, -1.16 none-in-out SNCnio in-out ActLoopNT-in 2.85 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -115.41, -44.98 APE9-dihe-na -99.02, -152.38 APE8-dihe-in -72.06, 134.26 APE8-rot-in 284.45 APE67-dihe-in -61.84, -37.14 -105.15, 28.83 APE12-dist-in 12.985 APE11-dist-in 12.438 APE10-dist-out 8.315 APE9-dist-out 8.181 K38R None None XRAY 2.15 0.176 0.216 A 403 357 0 0 0 0 [[9, 275]] 1.0 4xhg Candida glabrata CK1_HRR25_CANGA CK1 2.6e-101 344.7 1 261 261 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 non-specific serine/threonine protein kinase
AGC PRKACA KAPCA_CRIGR 6EM6A P25321 12 351 351.0 ADP:60401 ATPlike Inactive DFGin 6.859 14.821 BLAminus -128.32, 163.45 74.87, 92.52 -104.27, 28.45 286.23, 74.8 -62.75, -23.58 in-out in 9.704 Saltbr-out 4.362 HRD-in -85.36, -55.87 71.35, 12.71 out-in-in SNCoii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.91, 157.75 APE9-dihe-na 127.42, -164.4 APE8-dihe-in -115.9, 133.37 APE8-rot-in 304.12 APE67-dihe-in -57.32, -23.54 -48.16, -51.44 APE12-dist-in 8.046 APE11-dist-in 11.309 APE10-dist-in 5.737 APE9-dist-in 3.819 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.64 0.175 0.191 A 353 340 0 0 0 0 [[44, 298]] 1.0 6em6 Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6EM7A P25321 11 351 351.0 ADP:60403 ATPlike Active DFGin 5.924 14.338 BLAminus -118.71, 173.1 68.53, 85.06 -96.18, 23.36 270.78, 55.34 -59.75, -28.55 in-in in 8.741 Saltbr-in 2.711 HRD-in -88.33, -53.93 74.88, 10.19 in-in-in SNCiii in-in ActLoopNT-in 2.967 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.73, 159.92 APE9-dihe-na 127.98, -160.75 APE8-dihe-in -119.5, 137.47 APE8-rot-in 298.57 APE67-dihe-in -59.39, -22.73 -49.47, -50.59 APE12-dist-in 8.05 APE11-dist-in 11.429 APE10-dist-in 5.809 APE9-dist-in 3.674 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.238 0.139 0.157 A 353 341 0 0 0 0 [[44, 298]] 1.0 6em7 Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CMGC CDK Q5CRJ8_CRYPI 3NIZA Q5CRJ8 1 293 295.0 ADP:60314 ATPlike Inactive DFGin 6.414 14.921 BLAminus -148.14, 171.85 62.34, 76.33 -90.55, 26.42 283.17, 83.82 -64.08, -27.13 in-in in 9.199 Saltbr-in 3.051 HRD-in -69.04, -53.75 72.92, -5.13 in-in-out SNCiio in-out ActLoopNT-in 2.904 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -75.55, 106.41 APE9-dihe-na -120.78, 159.03 APE8-dihe-in -63.65, 138.42 APE8-rot-out 189.36 APE67-dihe-in -64.68, -19.03 -103.04, 13.52 APE12-dist-in 10.7 APE11-dist-in 9.767 APE10-dist-out 13.892 APE9-dist-out 9.548 None None None XRAY 2.4 0.223 0.256 A 311 284 9 0 0 3 [[5, 286]] 1.0 3niz Cryptosporidium parvum CMGC_CDK_CRYPI CMGC 1.9e-86 296.3 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 2 homolog
CAMK PLK1 Q4KMI8_DANRE 3D5WA Q4KMI8 24 310 595.0 ADP:313 ATPlike Inactive DFGin 5.84 15.103 BLAminus -136.31, -173.3 52.58, 90.43 -100.9, 29.72 290.61, 88.81 -67.31, -18.54 out-out out 10.538 Saltbr-out 4.57 HRD-in -72.81, -47.33 67.56, -5.93 out-in-in SNCoii in-in ActLoopNT-in 2.901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.0, 153.74 APE9-dihe-na 145.11, -167.91 APE8-dihe-in -110.25, 127.19 APE8-rot-in 299.86 APE67-dihe-in -70.02, -15.96 -37.98, -47.89 APE12-dist-in 8.251 APE11-dist-in 11.275 APE10-dist-in 5.646 APE9-dist-in 3.912 None TPO196 TPO196 XRAY 2.6 0.244 0.271 A 317 285 2 0 0 0 [[39, 291]] 1.0 3d5w Danio rerio CAMK_PLK1_DANRE CAMK 4.6e-77 264.7 1 256 256 179 180 181 183 185 68 87 91 159 161 160 162 219 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase PLK
OTHER POMK SG196_DANRE 5GZAA Q5U3W1 53 342 347.0 ADP:401,ZZ1:405 ATPlike,Allosteric Pseudo DFGin 5.357 13.174 None -145.49, -53.43 -88.36, 87.6 -105.44, 34.02 303.67, 0.43 -66.19, -35.84 none-na none 999.0 Saltbr-na 999.0 HRD-out -76.02, 100.34 -84.46, -37.81 na-in-out SNCaio in-out ActLoopNT-in 3.176 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iioo APE10-dihe-na -72.0, 131.22 APE9-dihe-na -98.58, 149.02 APE8-dihe-in -137.88, 170.05 APE8-rot-out 49.36 APE67-dihe-out -89.83, -15.07 100.95, 169.89 APE12-dist-in 12.164 APE11-dist-in 13.936 APE10-dist-out 17.359 APE9-dist-out 9.415 None None None XRAY 2.0 0.203 0.218 A 290 290 0 0 0 0 [[72, 335]] 1.0 5gza Danio rerio OTHER_POMK_DANRE POMK 3.3e-138 465.4 1 265 265 224 225 226 228 230 106 120 124 199 201 200 202 278 254 249 248 247 246 245 244 243 148 Protein O-mannose kinase
CAMK CAMKII KCC2A_DROME 5FG8A Q00168 7 275 530.0 ADP:301 ATPlike Active DFGin 5.883 14.23 BLAminus -120.35, -179.38 64.2, 77.37 -92.62, 22.59 287.14, 78.3 -59.18, -27.49 in-in in 8.996 Saltbr-in 2.798 HRD-in -79.26, -45.5 78.31, -3.25 in-in-in SNCiii in-in ActLoopNT-in 2.936 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.29, 153.59 APE9-dihe-na 138.39, -158.82 APE8-dihe-in -123.15, 126.57 APE8-rot-in 291.32 APE67-dihe-in -61.12, -15.42 -38.96, -61.46 APE12-dist-in 10.208 APE11-dist-in 11.816 APE10-dist-in 6.289 APE9-dist-in 3.479 None None None XRAY 1.955 0.192 0.221 A 285 269 0 0 0 0 [[14, 272]] 1.0 5fg8 Drosophila melanogaster CAMK_CAMKII_DROME CAMK 6.3e-98 333.1 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II alpha chain
CAMK CAMKII KCC2A_DROME 5HU3A Q00168 7 272 530.0 ADP:301 ATPlike Active DFGin 5.625 14.217 BLAminus -125.3, -175.54 57.54, 73.58 -90.7, 26.83 289.37, 84.29 -62.44, -29.23 in-in in 8.952 Saltbr-in 2.671 HRD-in -75.88, -45.31 74.57, -1.26 in-in-in SNCiii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.12, 157.18 APE9-dihe-na 139.99, -158.88 APE8-dihe-in -121.63, 130.83 APE8-rot-in 294.31 APE67-dihe-in -66.75, -12.95 -42.37, -59.45 APE12-dist-in 10.059 APE11-dist-in 11.766 APE10-dist-in 6.277 APE9-dist-in 3.564 D136N None None XRAY 1.885 0.194 0.228 A 285 266 0 0 0 0 [[14, 272]] 1.0 5hu3 Drosophila melanogaster CAMK_CAMKII_DROME CAMK 5.7e-97 329.9 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II alpha chain
CAMK OBSCN-1 OBSCN_DROME 8AK3A A8DYP0 3186 3477 4218.0 ADP:63501 ATPlike Pseudo DFGin 5.905 13.485 BLAminus -132.07, -172.8 60.67, 81.34 -101.92, 21.49 307.26, 110.13 -57.27, -33.59 in-in in 7.72 Saltbr-in 2.761 HRD-in -74.37, -46.4 81.73, -14.06 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -140.07, 151.0 APE9-dihe-na 162.46, 172.55 APE8-dihe-in -86.0, 119.15 APE8-rot-na 203.36 APE67-dihe-in -78.57, -5.95 -56.15, -31.0 APE12-dist-in 8.047 APE11-dist-in 10.008 APE10-dist-in 6.691 APE9-dist-in 5.787 None None None XRAY 1.9 0.175 0.208 A 297 292 0 0 0 0 [[3186, 3440], [3897, 4151]] 2.0 8ak3 Drosophila melanogaster CAMK_OBSCN-1_DROME CAMK 2.3e-61 213.3 1 256 256 3325 3326 3327 3329 3331 3215 3230 3234 3303 3305 3304 3306 3364 3352 3347 3346 3345 3344 3343 3342 3341 3260 Protein Obscurin
OTHER BUBR1 A1Z6I7_DROME 6JKMA A1Z6I7 1127 1459 1460.0 ADP:61501 ATPlike Inactive DFGin 6.009 13.948 BLAminus -128.73, 177.45 65.82, 73.45 -92.38, 26.0 302.65, 107.99 -57.62, -35.04 in-in in 8.333 Saltbr-in 2.987 HRD-in -63.93, -46.09 73.48, 2.84 in-in-out SNCiio in-out ActLoopNT-in 2.755 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooo APE10-dihe-na -54.34, 146.08 APE9-dihe-na -76.3, -56.25 APE8-dihe-in -62.83, 122.42 APE8-rot-na 191.74 APE67-dihe-in -57.79, -24.72 -57.87, -34.67 APE12-dist-in 12.122 APE11-dist-out 15.974 APE10-dist-out 12.426 APE9-dist-out 12.395 None None None XRAY 1.95 0.181 0.226 A 341 333 0 0 0 0 [[1175, 1438]] 1.0 6jkm Drosophila melanogaster OTHER_BUBR1_DROME BUB 7.6e-133 447.7 1 265 265 1325 1326 1327 1329 1331 1204 1213 1217 1298 1300 1299 1301 1367 1355 1350 1349 1348 1347 1346 1345 1344 1251 Bub1-related kinase
CAMK CDPK Q3HNM4_EIMTE 4YSJA Q3HNM4 26 499 505.0 ADP:60506 ATPlike Active DFGin 6.651 14.005 BLAminus -140.39, -165.72 52.75, 66.63 -84.34, 22.0 285.15, 82.54 -78.31, -16.63 in-in in 8.319 Saltbr-in 3.482 HRD-in -81.29, -53.0 84.02, -6.2 in-in-in SNCiii in-in ActLoopNT-in 2.898 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.58, 142.92 APE9-dihe-na 138.88, -163.22 APE8-dihe-in -136.98, 140.82 APE8-rot-in 303.29 APE67-dihe-in -62.88, -33.46 -45.59, -53.66 APE12-dist-in 9.144 APE11-dist-in 11.564 APE10-dist-in 5.99 APE9-dist-in 3.493 None None None XRAY 2.7 0.249 0.292 A 491 459 10 0 0 0 [[46, 303]] 1.0 4ysj Eimeria tenella CAMK_CDPK_EIMTE CAMK 6.1e-90 307.2 1 256 256 189 190 191 193 195 75 94 98 166 168 167 169 227 216 211 210 209 208 207 206 205 124 non-specific serine/threonine protein kinase
CAMK CDPK Q3HNM4_EIMTE 4YSJB Q3HNM4 26 499 505.0 ADP:60506 ATPlike Active DFGin 6.595 13.993 BLAminus -140.54, -165.92 54.1, 65.38 -84.49, 22.28 285.29, 82.38 -78.18, -16.85 in-in in 8.3 Saltbr-in 3.494 HRD-in -81.3, -52.72 84.55, -6.86 in-in-in SNCiii in-in ActLoopNT-in 2.869 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.46, 142.21 APE9-dihe-na 137.64, -162.65 APE8-dihe-in -138.56, 141.54 APE8-rot-in 303.24 APE67-dihe-in -62.83, -32.98 -44.74, -55.37 APE12-dist-in 8.901 APE11-dist-in 11.534 APE10-dist-in 5.979 APE9-dist-in 3.505 None None None XRAY 2.7 0.249 0.292 B 491 462 10 0 0 0 [[46, 303]] 1.0 4ysj Eimeria tenella CAMK_CDPK_EIMTE CAMK 6.1e-90 307.2 1 256 256 189 190 191 193 195 75 94 98 166 168 167 169 227 216 211 210 209 208 207 206 205 124 non-specific serine/threonine protein kinase
AGC CDC42BPB MRCKB_HUMAN 4UAKA Q9Y5S2 2 417 1711.0 ADP:60501 ATPlike Active DFGin 6.536 13.389 BLAminus -126.67, 169.91 71.43, 81.15 -99.11, 14.11 300.02, 102.96 -73.12, -5.53 in-in in 8.635 Saltbr-in 2.748 HRD-in -78.82, -49.28 69.95, 4.01 in-in-in SNCiii in-in ActLoopNT-in 2.977 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.28, 157.85 APE9-dihe-na 87.21, -164.86 APE8-dihe-in -127.15, 132.61 APE8-rot-in 302.21 APE67-dihe-in -64.23, -20.61 -57.86, -36.49 APE12-dist-in 10.511 APE11-dist-in 11.151 APE10-dist-in 6.313 APE9-dist-in 3.548 None None None XRAY 1.73 0.198 0.243 A 419 401 0 0 0 0 [[76, 342]] 1.0 4uak Homo sapiens AGC_CDC42BPB_HUMAN AGC 6.5e-96 326.4 1 260 260 217 218 219 221 223 105 124 128 197 199 198 200 263 246 241 240 239 238 237 236 235 154 Serine/threonine-protein kinase MRCK beta
AGC PRKCI KPCI_HUMAN 5LIHA P41743 248 588 596.0 ADP:60601 ATPlike Active DFGin 5.403 11.863 BLAminus -129.58, 178.7 63.64, 84.98 -106.19, 67.5 320.36, 105.86 -96.86, -30.05 in-in in 9.178 Saltbr-in 3.031 HRD-in -49.42, -59.61 61.3, 24.72 in-in-in SNCiii in-in ActLoopNT-in 3.109 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.76, 169.43 APE9-dihe-na 122.35, -170.42 APE8-dihe-in -91.96, 136.55 APE8-rot-in 289.3 APE67-dihe-in -72.22, -23.04 -49.75, -40.52 APE12-dist-in 7.983 APE11-dist-in 10.986 APE10-dist-in 5.421 APE9-dist-in 3.56 None TPO412,TPO564 TPO412,TPO564 XRAY 3.25 0.258 0.284 A 349 326 15 0 0 0 [[254, 522]] 1.0 5lih Homo sapiens AGC_PRKCI_HUMAN AGC 1.1e-95 325.5 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 5LIHB P41743 249 588 596.0 ADP:60601 ATPlike Active DFGin 5.31 11.876 BLAminus -129.18, 178.42 63.46, 84.62 -106.43, 67.35 320.63, 105.98 -96.29, -29.69 in-in in 8.72 Saltbr-in 2.545 HRD-in -49.62, -59.64 61.27, 24.64 in-in-in SNCiii in-in ActLoopNT-in 3.141 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.47, 168.99 APE9-dihe-na 122.16, -170.23 APE8-dihe-in -91.66, 136.86 APE8-rot-in 289.24 APE67-dihe-in -72.3, -22.91 -49.4, -40.32 APE12-dist-in 8.329 APE11-dist-in 11.256 APE10-dist-in 5.693 APE9-dist-in 3.742 None TPO412,TPO564 TPO412,TPO564 XRAY 3.25 0.258 0.284 B 349 320 20 0 0 0 [[254, 522]] 1.0 5lih Homo sapiens AGC_PRKCI_HUMAN AGC 1.1e-95 325.5 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 9EJMB P41743 249 588 596.0 ADP:60601 ATPlike None DFGin 6.2 12.865 BLAminus -142.99, -166.55 58.77, 70.37 -95.2, 28.65 312.71, 127.0 -80.74, 2.56 in-none in 9.166 Saltbr-none 999.0 HRD-in -62.9, -53.16 64.41, -0.47 none-in-in SNCnii in-in ActLoopNT-in 3.152 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.58, 153.63 APE9-dihe-na 128.65, 169.74 APE8-dihe-in -69.25, 127.47 APE8-rot-in 310.74 APE67-dihe-in -76.65, -32.17 -60.48, -21.91 APE12-dist-in 9.603 APE11-dist-in 12.253 APE10-dist-in 6.595 APE9-dist-in 3.928 None TPO412,TPO564 TPO412,TPO564 EM 3.33 999.0 999.0 B 596 322 9 0 0 0 [[254, 522]] 1.0 9ejm Homo sapiens AGC_PRKCI_HUMAN AGC 5.2e-95 323.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
CAMK AURKA AURKA_HUMAN 8GUWA O14965 506 388 403.0 ADP:60501 ATPlike Inactive DFGin 5.496 16.001 ABAminus -116.4, -50.49 -101.78, 116.28 -108.31, 28.43 281.67, 88.04 -72.88, -24.68 out-out out 11.779 Saltbr-out 6.963 HRD-out -52.32, 144.81 -137.03, 32.44 out-in-out SNCoio in-out ActLoopNT-in 2.989 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 154.24 APE8-dihe-in -135.99, 160.18 APE8-rot-out 182.57 APE67-dihe-in -45.22, -30.26 -102.15, -5.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 22.835 C290A,C393A None None XRAY 2.7 0.216 0.258 A 304 259 7 0 0 7 [[133, 383]] 1.0 8guw Homo sapiens CAMK_AURKA_HUMAN CAMK 1.2e-78 270.0 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8GUWB O14965 507 390 403.0 ADP:60501 ATPlike Inactive DFGin 5.29 15.684 ABAminus -103.46, -56.86 -84.59, 164.71 -149.11, 43.73 280.55, 102.4 -37.77, -51.78 out-out out 11.222 Saltbr-out 10.124 HRD-out -88.2, 114.65 -57.32, -35.01 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 120.59 APE8-rot-out 188.97 APE67-dihe-out 79.95, -4.59 -68.08, -173.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C290A,C393A None None XRAY 2.7 0.216 0.258 B 304 250 13 0 0 13 [[133, 383]] 1.0 8guw Homo sapiens CAMK_AURKA_HUMAN CAMK 1.2e-78 270.0 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8GUWC O14965 506 388 403.0 ADP:60501 ATPlike Inactive DFGin 5.794 16.123 ABAminus -112.39, -57.42 -66.39, 155.71 -143.31, 23.7 266.43, 102.44 -50.18, -24.58 out-out out 11.531 Saltbr-out 6.147 HRD-out -98.37, 113.81 -121.54, 28.92 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -46.16 APE8-rot-in 299.01 APE67-dihe-in -63.17, -8.64 -58.96, -54.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C290A,C393A None None XRAY 2.7 0.216 0.258 C 304 248 18 0 0 14 [[133, 383]] 1.0 8guw Homo sapiens CAMK_AURKA_HUMAN CAMK 1.2e-78 270.0 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4BN1A O14965 126 388 403.0 ADP:1391 ATPlike Inactive DFGin 5.759 14.962 BLAminus -135.76, 176.64 57.4, 85.44 -97.06, 20.67 283.26, 70.95 -48.27, -40.43 in-in in 9.228 Saltbr-in 2.717 HRD-in -70.78, -55.66 70.88, -1.02 in-in-out SNCiio in-out ActLoopNT-in 2.8 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na 16.45, -154.0 APE9-dihe-na 66.92, -173.53 APE8-dihe-in -66.46, 155.86 APE8-rot-out 182.79 APE67-dihe-in -44.49, -32.18 -93.83, -6.12 APE12-dist-in 12.114 APE11-dist-in 8.731 APE10-dist-out 13.707 APE9-dist-out 11.159 V174M TPO287,TPO288 TPO287,TPO288 XRAY 2.499 0.195 0.244 A 285 263 0 0 0 0 [[133, 383]] 1.0 4bn1 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.5e-80 273.9 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 1MQ4A O14965 126 388 403.0 ADP:2001 ATPlike Inactive DFGin 5.607 15.213 BLAminus -132.59, 179.34 62.49, 72.25 -91.07, 21.51 279.91, 70.01 -61.32, -27.71 in-in in 9.055 Saltbr-in 2.88 HRD-in -82.66, -49.31 72.48, -1.39 in-in-out SNCiio in-out ActLoopNT-in 2.923 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -97.21, -164.83 APE9-dihe-na -146.02, -127.82 APE8-dihe-in -61.49, 131.42 APE8-rot-out 178.11 APE67-dihe-in -51.42, -34.84 -86.66, -6.25 APE12-dist-in 7.681 APE11-dist-in 11.847 APE10-dist-out 10.587 APE9-dist-out 9.978 None None None XRAY 1.9 0.229 0.273 A 272 261 2 0 0 2 [[133, 383]] 1.0 1mq4 Homo sapiens CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 1OL5A O14965 123 388 403.0 ADP:1388 ATPlike Active DFGin 5.578 15.096 BLAminus -139.2, -172.08 52.22, 80.16 -90.83, 24.66 282.61, 72.55 -49.87, -44.18 in-in in 9.451 Saltbr-in 2.912 HRD-in -63.28, -60.88 73.6, 1.59 in-in-in SNCiii in-in ActLoopNT-in 2.928 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.42, 162.5 APE9-dihe-na 119.45, -153.19 APE8-dihe-in -110.77, 140.24 APE8-rot-in 313.06 APE67-dihe-in -62.23, -14.3 -43.16, -62.5 APE12-dist-in 8.174 APE11-dist-in 10.957 APE10-dist-in 5.274 APE9-dist-in 3.683 None TPO287,TPO288 TPO287,TPO288 XRAY 2.5 0.194 0.252 A 282 266 0 0 0 0 [[133, 383]] 1.0 1ol5 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 1OL7A O14965 127 390 403.0 ADP:531 ATPlike Inactive DFGin 5.429 15.043 BLAminus -133.12, -167.56 48.98, 74.14 -88.94, 32.44 285.93, 64.91 -57.61, -36.14 in-in in 9.506 Saltbr-in 3.055 HRD-in -75.56, -48.34 63.05, 5.8 in-in-out SNCiio in-out ActLoopNT-in 2.978 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -104.11, 138.56 APE9-dihe-na 156.93, 143.05 APE8-dihe-in -89.37, 102.83 APE8-rot-out 182.11 APE67-dihe-in -15.17, -56.94 -45.24, -37.82 APE12-dist-in 11.267 APE11-dist-in 11.206 APE10-dist-out 10.465 APE9-dist-out 8.269 None TPO287,TPO288 TPO287,TPO288 XRAY 2.75 0.257 0.296 A 282 264 0 0 0 0 [[133, 383]] 1.0 1ol7 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4DEEA O14965 124 394 403.0 ADP:503 ATPlike Inactive DFGin 5.977 15.579 BLAminus -131.54, -177.86 61.33, 72.14 -88.35, 17.45 278.56, 69.2 -56.76, -24.29 in-in in 9.236 Saltbr-in 2.836 HRD-in -80.53, -51.88 66.61, 1.43 in-in-out SNCiio in-out ActLoopNT-in 2.686 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -125.87, -53.37 APE9-dihe-na -86.66, -134.63 APE8-dihe-in -80.8, 152.73 APE8-rot-out 187.03 APE67-dihe-in -37.34, -40.8 -92.92, -9.81 APE12-dist-in 12.108 APE11-dist-in 10.787 APE10-dist-out 10.762 APE9-dist-out 10.532 T287D None None XRAY 2.3 0.213 0.259 A 279 271 0 0 0 0 [[133, 383]] 1.0 4dee Homo sapiens CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5LXMA O14965 126 392 403.0 ADP:60501 ATPlike Active DFGin 5.391 14.976 BLAminus -135.45, -179.78 54.7, 80.97 -90.8, 30.12 283.16, 71.51 -72.4, -3.16 in-in in 9.247 Saltbr-in 2.724 HRD-in -74.23, -48.55 66.99, 5.01 in-in-in SNCiii in-in ActLoopNT-in 3.114 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.91, 137.37 APE9-dihe-na 128.62, -150.21 APE8-dihe-in -129.87, 142.81 APE8-rot-in 303.47 APE67-dihe-in -69.71, -10.62 -37.99, -61.07 APE12-dist-in 8.257 APE11-dist-in 10.692 APE10-dist-in 5.213 APE9-dist-in 3.298 C290A,C393A TPO288 TPO288 XRAY 2.08 0.202 0.243 A 283 267 0 0 0 0 [[133, 383]] 1.0 5lxm Homo sapiens CAMK_AURKA_HUMAN CAMK 9.2e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4CEGA O14965 127 391 403.0 ADP:1392 ATPlike Inactive DFGin 6.321 15.665 BLAminus -126.79, -176.42 60.85, 65.85 -88.73, 20.26 276.07, 70.68 -62.71, -30.16 in-in in 8.907 Saltbr-in 2.752 HRD-in -80.9, -50.34 70.05, 0.74 in-in-out SNCiio in-out ActLoopNT-in 2.882 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -88.79, -42.25 APE9-dihe-na -103.79, -144.9 APE8-dihe-in -67.83, 148.92 APE8-rot-out 184.96 APE67-dihe-in -49.78, -34.34 -90.88, -2.74 APE12-dist-in 12.035 APE11-dist-in 10.991 APE10-dist-out 11.5 APE9-dist-out 10.933 C290A,C393A TPO288 TPO288 XRAY 2.1 0.202 0.237 A 285 265 0 0 0 0 [[133, 383]] 1.0 4ceg Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5G1XA O14965 126 389 403.0 ADP:1390 ATPlike Active DFGin 5.343 15.03 BLAminus -132.86, -170.57 52.68, 76.5 -90.96, 13.96 279.12, 78.43 -59.51, -20.51 in-in in 9.278 Saltbr-in 2.828 HRD-in -82.61, -50.12 70.7, 5.33 in-in-in SNCiii in-in ActLoopNT-in 2.963 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.42, -179.26 APE9-dihe-na 65.74, -155.89 APE8-dihe-in -128.23, 121.78 APE8-rot-in 304.75 APE67-dihe-in -61.27, -19.7 -46.07, -47.67 APE12-dist-in 8.247 APE11-dist-in 10.799 APE10-dist-in 5.53 APE9-dist-in 3.699 C290A,C393A TPO288 TPO288 XRAY 1.72 0.177 0.195 A 285 264 0 0 0 0 [[133, 383]] 1.0 5g1x Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORLA O14965 127 391 403.0 ADP:401,A4W:407 ATPlike,Allosteric Inactive DFGin 7.066 16.649 BLAminus -127.84, -172.28 56.81, 60.19 -82.35, 15.9 271.2, 75.61 -63.85, -28.67 in-in in 9.049 Saltbr-in 2.75 HRD-in -78.27, -48.5 74.34, -1.48 in-in-out SNCiio in-out ActLoopNT-in 2.977 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -99.11, -104.69 APE9-dihe-na -74.24, -110.44 APE8-dihe-in -76.15, 148.12 APE8-rot-out 189.45 APE67-dihe-in -56.74, -24.81 -85.95, -8.4 APE12-dist-in 12.072 APE11-dist-in 10.971 APE10-dist-out 10.388 APE9-dist-out 11.289 C290A TPO288 TPO288 XRAY 1.69 0.206 0.238 A 265 265 0 0 0 0 [[133, 383]] 1.0 5orl Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORNA O14965 127 391 403.0 ADP:401,A5E:404 ATPlike,Allosteric Inactive DFGin 5.672 15.403 BLAminus -130.34, -174.38 54.92, 79.97 -94.37, 17.54 279.26, 75.58 -55.07, -30.09 in-in in 9.354 Saltbr-in 2.929 HRD-in -81.32, -50.86 72.88, 0.4 in-in-out SNCiio in-out ActLoopNT-in 3.025 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -63.8, -59.63 APE9-dihe-na -97.49, -117.04 APE8-dihe-in -91.34, 143.03 APE8-rot-out 191.17 APE67-dihe-in -51.25, -26.05 -82.57, -15.54 APE12-dist-in 12.386 APE11-dist-in 10.402 APE10-dist-out 11.494 APE9-dist-out 11.357 None TPO288 TPO288 XRAY 2.19 0.203 0.262 A 265 265 0 0 0 0 [[133, 383]] 1.0 5orn Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OROA O14965 127 391 403.0 ADP:401,A5H:404 ATPlike,Allosteric Inactive DFGin 5.678 15.337 BLAminus -140.88, -178.26 60.46, 77.77 -94.07, 18.69 277.24, 76.82 -52.63, -39.97 in-in in 9.273 Saltbr-in 3.057 HRD-in -74.27, -52.41 74.24, -3.23 in-in-out SNCiio in-out ActLoopNT-in 2.843 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -87.43, -63.56 APE9-dihe-na -103.72, -111.07 APE8-dihe-in -78.78, 141.92 APE8-rot-out 181.93 APE67-dihe-in -53.21, -24.39 -89.75, -10.63 APE12-dist-in 12.176 APE11-dist-in 10.559 APE10-dist-out 11.001 APE9-dist-out 11.501 None TPO288 TPO288 XRAY 2.12 0.223 0.281 A 265 265 0 0 0 0 [[133, 383]] 1.0 5oro Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORPA O14965 127 391 403.0 ADP:401,A5K:404 ATPlike,Allosteric Inactive DFGin 5.812 15.492 BLAminus -139.84, -179.78 59.55, 79.52 -94.35, 18.72 278.85, 73.24 -45.22, -42.84 in-in in 9.387 Saltbr-in 2.908 HRD-in -83.1, -49.94 72.65, -1.94 in-in-out SNCiio in-out ActLoopNT-in 3.034 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -75.76, -64.68 APE9-dihe-na -107.0, -110.58 APE8-dihe-in -81.78, 136.28 APE8-rot-out 180.06 APE67-dihe-in -57.19, -28.31 -85.06, -6.26 APE12-dist-in 12.351 APE11-dist-in 10.944 APE10-dist-out 10.766 APE9-dist-out 11.367 None TPO288 TPO288 XRAY 2.19 0.21 0.273 A 265 265 0 0 0 0 [[133, 383]] 1.0 5orp Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORRA O14965 127 391 403.0 ADP:401,A5Q:404 ATPlike,Allosteric Inactive DFGin 5.665 15.497 BLAminus -133.78, -179.48 60.85, 73.72 -91.04, 29.58 281.03, 75.21 -67.99, -25.16 in-in in 9.421 Saltbr-in 3.055 HRD-in -80.95, -50.87 71.36, -2.01 in-in-out SNCiio in-out ActLoopNT-in 3.021 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -79.12, -78.89 APE9-dihe-na -94.43, -116.97 APE8-dihe-in -78.43, 147.39 APE8-rot-out 182.93 APE67-dihe-in -56.59, -23.94 -94.11, -3.91 APE12-dist-in 12.261 APE11-dist-in 11.02 APE10-dist-out 10.427 APE9-dist-out 11.066 None TPO288 TPO288 XRAY 2.09 0.202 0.256 A 265 265 0 0 0 0 [[133, 383]] 1.0 5orr Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORSA O14965 127 391 403.0 ADP:401,A5W:404 ATPlike,Allosteric Inactive DFGin 5.955 15.683 BLAminus -133.47, -175.79 56.95, 73.99 -92.77, 17.89 276.34, 75.78 -60.0, -24.97 in-in in 9.175 Saltbr-in 2.899 HRD-in -79.83, -50.16 70.98, -0.5 in-in-out SNCiio in-out ActLoopNT-in 3.002 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -90.64, -79.2 APE9-dihe-na -92.74, -115.85 APE8-dihe-in -81.19, 144.15 APE8-rot-out 184.83 APE67-dihe-in -58.67, -28.41 -85.39, -4.34 APE12-dist-in 12.193 APE11-dist-in 10.956 APE10-dist-out 10.626 APE9-dist-out 11.291 None TPO288 TPO288 XRAY 1.98 0.209 0.257 A 265 265 0 0 0 0 [[133, 383]] 1.0 5ors Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORTA O14965 127 391 403.0 ADP:401,A5Z:406 ATPlike,Allosteric Inactive DFGin 5.999 15.754 BLAminus -125.96, -170.73 54.43, 75.09 -90.85, 19.73 277.07, 68.86 -49.78, -34.73 in-in in 9.196 Saltbr-in 3.026 HRD-in -79.74, -50.38 68.95, 1.55 in-in-out SNCiio in-out ActLoopNT-in 3.084 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -85.06, -64.36 APE9-dihe-na -96.27, -115.21 APE8-dihe-in -89.65, 146.92 APE8-rot-out 194.22 APE67-dihe-in -52.62, -22.53 -93.73, -12.57 APE12-dist-in 12.531 APE11-dist-in 10.919 APE10-dist-out 10.824 APE9-dist-out 11.018 None TPO288 TPO288 XRAY 2.56 0.208 0.275 A 265 265 0 0 0 0 [[133, 383]] 1.0 5ort Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORVA O14965 127 391 403.0 ADP:401,A65:406 ATPlike,Allosteric Inactive DFGin 5.665 15.44 BLAminus -136.16, -176.05 58.92, 71.82 -89.03, 22.25 278.38, 76.78 -63.69, -25.31 in-in in 9.245 Saltbr-in 2.886 HRD-in -82.57, -52.35 73.38, 1.05 in-in-out SNCiio in-out ActLoopNT-in 3.006 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -75.39, -87.03 APE9-dihe-na -89.16, -112.46 APE8-dihe-in -77.62, 139.73 APE8-rot-out 181.74 APE67-dihe-in -57.59, -25.24 -84.67, -4.17 APE12-dist-in 12.313 APE11-dist-in 10.877 APE10-dist-out 10.421 APE9-dist-out 11.255 None TPO288 TPO288 XRAY 1.88 0.214 0.268 A 265 265 0 0 0 0 [[133, 383]] 1.0 5orv Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORWA O14965 127 391 403.0 ADP:401,A6E:404 ATPlike,Allosteric Inactive DFGin 5.706 15.413 BLAminus -131.01, -175.69 56.41, 78.46 -94.05, 21.38 277.67, 78.36 -59.98, -27.55 in-in in 9.316 Saltbr-in 3.005 HRD-in -84.25, -51.01 70.55, 2.29 in-in-out SNCiio in-out ActLoopNT-in 3.069 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -84.32, -59.08 APE9-dihe-na -102.85, -110.93 APE8-dihe-in -86.24, 134.05 APE8-rot-out 178.0 APE67-dihe-in -62.04, -25.17 -80.18, -4.89 APE12-dist-in 12.269 APE11-dist-in 10.81 APE10-dist-out 10.98 APE9-dist-out 11.2 None TPO288 TPO288 XRAY 2.0 0.217 0.27 A 265 265 0 0 0 0 [[133, 383]] 1.0 5orw Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORXA O14965 127 391 403.0 ADP:401,A6H:404 ATPlike,Allosteric Inactive DFGin 5.483 15.332 BLAminus -135.37, -175.69 58.5, 74.51 -88.48, 21.31 281.01, 74.45 -55.7, -31.23 in-in in 9.392 Saltbr-in 2.887 HRD-in -84.87, -52.92 73.65, 2.44 in-in-out SNCiio in-out ActLoopNT-in 2.957 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -81.41, -75.31 APE9-dihe-na -97.77, -112.93 APE8-dihe-in -77.56, 136.59 APE8-rot-out 185.81 APE67-dihe-in -60.3, -23.27 -81.45, -7.22 APE12-dist-in 12.271 APE11-dist-in 10.976 APE10-dist-out 10.248 APE9-dist-out 10.921 None TPO288 TPO288 XRAY 1.88 0.222 0.27 A 265 265 0 0 0 0 [[133, 383]] 1.0 5orx Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORYA O14965 127 391 403.0 ADP:401,AY4:406 ATPlike,Allosteric Inactive DFGin 5.665 15.432 BLAminus -133.35, -178.83 58.64, 81.27 -98.02, 26.99 280.05, 73.77 -66.34, -26.48 in-in in 9.413 Saltbr-in 3.015 HRD-in -83.1, -49.94 67.85, 0.8 in-in-out SNCiio in-out ActLoopNT-in 2.968 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -85.35, -78.87 APE9-dihe-na -90.27, -119.1 APE8-dihe-in -76.79, 146.69 APE8-rot-out 180.58 APE67-dihe-in -53.43, -25.94 -95.91, -5.0 APE12-dist-in 12.447 APE11-dist-in 11.047 APE10-dist-out 10.743 APE9-dist-out 11.153 None TPO288 TPO288 XRAY 1.99 0.207 0.265 A 265 265 0 0 0 0 [[133, 383]] 1.0 5ory Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORZA O14965 127 391 403.0 ADP:401,A6W:407 ATPlike,Allosteric Inactive DFGin 5.675 15.407 BLAminus -135.57, -175.22 57.46, 80.66 -98.54, 24.2 276.77, 79.7 -65.5, -21.43 in-in in 9.254 Saltbr-in 3.111 HRD-in -80.39, -48.42 71.09, -2.39 in-in-out SNCiio in-out ActLoopNT-in 3.062 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -82.59, -77.55 APE9-dihe-na -100.89, -113.21 APE8-dihe-in -76.47, 144.8 APE8-rot-out 177.65 APE67-dihe-in -57.19, -24.65 -94.21, -4.24 APE12-dist-in 12.301 APE11-dist-in 10.888 APE10-dist-out 10.402 APE9-dist-out 11.21 None TPO288 TPO288 XRAY 1.92 0.199 0.244 A 265 265 0 0 0 0 [[133, 383]] 1.0 5orz Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS0A O14965 127 391 403.0 ADP:401,A6Z:404 ATPlike,Allosteric Inactive DFGin 5.663 15.441 BLAminus -133.76, -174.78 57.78, 75.99 -91.75, 21.09 277.99, 75.39 -60.35, -28.95 in-in in 9.311 Saltbr-in 2.788 HRD-in -86.51, -49.56 71.53, 0.91 in-in-out SNCiio in-out ActLoopNT-in 2.96 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -90.57, -76.63 APE9-dihe-na -103.27, -112.09 APE8-dihe-in -75.93, 143.74 APE8-rot-out 179.33 APE67-dihe-in -59.48, -25.37 -86.69, -3.69 APE12-dist-in 12.156 APE11-dist-in 10.864 APE10-dist-out 10.257 APE9-dist-out 11.204 None TPO288 TPO288 XRAY 1.74 0.22 0.264 A 265 265 0 0 0 0 [[133, 383]] 1.0 5os0 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS1A O14965 127 391 403.0 ADP:401,A7H:407 ATPlike,Allosteric Inactive DFGin 5.601 15.321 BLAminus -135.04, -179.66 61.87, 77.96 -95.19, 22.65 277.87, 73.62 -63.45, -26.73 in-in in 9.224 Saltbr-in 2.92 HRD-in -84.64, -47.57 66.67, 4.82 in-in-out SNCiio in-out ActLoopNT-in 3.016 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -71.95, -77.41 APE9-dihe-na -100.69, -116.41 APE8-dihe-in -72.42, 138.52 APE8-rot-out 177.77 APE67-dihe-in -60.13, -26.29 -83.6, -2.57 APE12-dist-in 12.239 APE11-dist-in 10.817 APE10-dist-out 10.599 APE9-dist-out 11.258 None TPO288 TPO288 XRAY 1.9 0.203 0.25 A 265 265 0 0 0 0 [[133, 383]] 1.0 5os1 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS2A O14965 127 391 403.0 ADP:401,A7K:404 ATPlike,Allosteric Inactive DFGin 5.698 15.529 BLAminus -131.21, -175.25 58.7, 76.84 -90.56, 21.45 276.93, 76.69 -62.35, -9.35 in-in in 9.309 Saltbr-in 2.976 HRD-in -79.13, -51.53 72.78, 2.45 in-in-out SNCiio in-out ActLoopNT-in 3.018 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -27.53 APE9-dihe-na -109.52, -133.64 APE8-dihe-in -78.79, 129.87 APE8-rot-out 174.59 APE67-dihe-in -60.88, -25.02 -78.66, -3.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.83 APE9-dist-out 10.957 None None None XRAY 1.92 0.213 0.251 A 265 261 4 0 0 4 [[133, 383]] 1.0 5os2 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS3A O14965 127 391 403.0 ADP:401,A7N:404 ATPlike,Allosteric Inactive DFGin 5.853 15.615 BLAminus -132.65, -178.67 63.71, 72.3 -91.21, 21.81 276.12, 75.45 -58.53, -29.86 in-in in 9.169 Saltbr-in 2.928 HRD-in -82.57, -48.69 69.82, -0.73 in-in-out SNCiio in-out ActLoopNT-in 2.966 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -97.05, -71.52 APE9-dihe-na -103.15, -115.69 APE8-dihe-in -76.83, 145.54 APE8-rot-out 186.8 APE67-dihe-in -55.71, -28.81 -87.14, -3.16 APE12-dist-in 12.183 APE11-dist-in 10.95 APE10-dist-out 10.376 APE9-dist-out 11.239 None TPO288 TPO288 XRAY 1.81 0.203 0.238 A 265 265 0 0 0 0 [[133, 383]] 1.0 5os3 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS4A O14965 127 391 403.0 ADP:401,A8H:404 ATPlike,Allosteric Inactive DFGin 5.562 15.388 BLAminus -130.51, -177.66 61.48, 75.55 -91.39, 22.5 279.03, 76.09 -60.73, -28.57 in-in in 9.245 Saltbr-in 2.862 HRD-in -82.71, -48.02 68.35, 3.92 in-in-out SNCiio in-out ActLoopNT-in 2.959 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -77.92, -67.81 APE9-dihe-na -96.69, -121.48 APE8-dihe-in -75.57, 137.34 APE8-rot-out 180.49 APE67-dihe-in -57.86, -25.07 -81.82, -5.88 APE12-dist-in 12.257 APE11-dist-in 10.803 APE10-dist-out 10.935 APE9-dist-out 11.259 None TPO288 TPO288 XRAY 1.88 0.205 0.24 A 265 265 0 0 0 0 [[133, 383]] 1.0 5os4 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS6A O14965 127 391 403.0 ADP:401,A7Q:404 ATPlike,Allosteric Inactive DFGin 6.029 15.781 BLAminus -126.13, -169.53 51.73, 76.81 -92.36, 19.58 272.42, 79.82 -57.78, -34.45 in-in in 9.245 Saltbr-in 2.995 HRD-in -81.41, -52.88 69.05, 4.37 in-in-out SNCiio in-out ActLoopNT-in 3.04 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -77.03, -70.53 APE9-dihe-na -90.32, -115.88 APE8-dihe-in -84.85, 141.6 APE8-rot-out 180.13 APE67-dihe-in -64.32, -26.41 -86.27, 0.74 APE12-dist-in 12.213 APE11-dist-in 10.826 APE10-dist-out 10.74 APE9-dist-out 10.992 None TPO288 TPO288 XRAY 2.2 0.216 0.277 A 265 265 0 0 0 0 [[133, 383]] 1.0 5os6 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OSEA O14965 127 391 403.0 ADP:401,A98:404 ATPlike,Allosteric Inactive DFGin 5.646 15.441 BLAminus -134.11, -176.47 59.39, 78.15 -96.43, 21.72 274.12, 77.75 -65.33, -24.45 in-in in 9.137 Saltbr-in 2.885 HRD-in -78.93, -49.87 70.59, 0.35 in-in-out SNCiio in-out ActLoopNT-in 2.959 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -81.25, -72.54 APE9-dihe-na -105.09, -114.94 APE8-dihe-in -73.18, 141.65 APE8-rot-out 184.53 APE67-dihe-in -56.53, -26.26 -88.57, -5.48 APE12-dist-in 12.15 APE11-dist-in 10.976 APE10-dist-out 10.508 APE9-dist-out 11.253 None TPO288 TPO288 XRAY 1.9 0.192 0.237 A 265 265 0 0 0 0 [[133, 383]] 1.0 5ose Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OSFA O14965 127 391 403.0 ADP:401,A9E:404 ATPlike,Allosteric Inactive DFGin 5.759 15.656 BLAminus -131.88, -178.74 65.35, 71.33 -84.84, 21.28 278.92, 73.36 -65.0, -27.04 in-in in 9.314 Saltbr-in 2.827 HRD-in -85.08, -46.49 62.7, 8.17 in-in-out SNCiio in-out ActLoopNT-in 2.965 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -87.68, -61.8 APE9-dihe-na -106.59, -110.06 APE8-dihe-in -85.81, 135.3 APE8-rot-out 180.39 APE67-dihe-in -56.65, -25.75 -79.56, -7.54 APE12-dist-in 12.204 APE11-dist-in 10.69 APE10-dist-out 10.913 APE9-dist-out 11.453 None TPO288 TPO288 XRAY 1.89 0.204 0.254 A 265 265 0 0 0 0 [[133, 383]] 1.0 5osf Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OSDA O14965 125 391 403.0 ADP:401,A9B:404 ATPlike,Allosteric Inactive DFGin 5.672 15.444 BLAminus -133.73, -178.01 59.76, 77.67 -95.6, 25.32 277.59, 73.38 -66.16, -23.93 in-in in 9.153 Saltbr-in 2.914 HRD-in -79.03, -50.3 71.01, -1.56 in-in-out SNCiio in-out ActLoopNT-in 3.037 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -81.55, -62.64 APE9-dihe-na -107.55, -120.42 APE8-dihe-in -75.26, 143.45 APE8-rot-out 177.88 APE67-dihe-in -54.13, -27.04 -91.57, -4.8 APE12-dist-in 12.25 APE11-dist-in 11.074 APE10-dist-out 10.806 APE9-dist-out 11.197 None TPO288 TPO288 XRAY 1.99 0.198 0.239 A 267 267 0 0 0 0 [[133, 383]] 1.0 5osd Homo sapiens CAMK_AURKA_HUMAN CAMK 7.4e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS5A O14965 125 392 403.0 ADP:401,A8K:404 ATPlike,Allosteric Inactive DFGin 5.536 15.275 BLAminus -135.35, -174.05 58.1, 79.63 -93.47, 22.72 276.13, 73.04 -64.31, -25.3 in-in in 9.38 Saltbr-in 2.868 HRD-in -80.2, -52.69 73.71, 2.64 in-in-out SNCiio in-out ActLoopNT-in 2.88 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -96.33, -47.43 APE9-dihe-na -104.6, -130.88 APE8-dihe-in -73.88, 139.12 APE8-rot-out 187.09 APE67-dihe-in -61.32, -25.92 -83.14, -4.09 APE12-dist-in 12.281 APE11-dist-in 10.845 APE10-dist-out 11.357 APE9-dist-out 10.954 None TPO288 TPO288 XRAY 1.74 0.199 0.236 A 268 268 0 0 0 0 [[133, 383]] 1.0 5os5 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.5e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6R49A O14965 127 391 403.0 ADP:501,JSB:504 ATPlike,Allosteric Inactive DFGin 5.614 15.457 BLAminus -138.43, -175.42 57.6, 78.22 -94.44, 21.89 276.25, 76.24 -57.77, -33.65 in-in in 9.381 Saltbr-in 2.894 HRD-in -87.16, -51.58 76.44, -3.34 in-in-out SNCiio in-out ActLoopNT-in 3.102 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -122.85 APE8-dihe-in -81.14, 140.15 APE8-rot-out 187.07 APE67-dihe-in -51.76, -30.76 -84.84, -7.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.053 C290A,C393A TPO288 TPO288 XRAY 2.209 0.194 0.24 A 285 260 5 0 0 5 [[133, 383]] 1.0 6r49 Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6R4AA O14965 127 391 403.0 ADP:501,JRT:510 ATPlike,Allosteric Inactive DFGin 6.157 15.949 BLAminus -128.43, -176.18 59.16, 64.31 -84.29, 19.22 274.78, 74.05 -63.59, -28.66 in-in in 9.102 Saltbr-in 2.825 HRD-in -85.32, -47.41 69.85, -3.89 in-in-out SNCiio in-out ActLoopNT-in 3.023 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -103.23, -102.89 APE9-dihe-na -87.4, -108.97 APE8-dihe-in -74.29, 145.29 APE8-rot-out 184.87 APE67-dihe-in -57.97, -25.59 -89.08, -1.69 APE12-dist-in 12.109 APE11-dist-in 10.868 APE10-dist-out 9.943 APE9-dist-out 11.448 C290A,C393A TPO288 TPO288 XRAY 1.937 0.193 0.234 A 285 265 0 0 0 0 [[133, 383]] 1.0 6r4a Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6R4BA O14965 127 391 403.0 ADP:501,JSN:508 ATPlike,Allosteric Inactive DFGin 5.894 15.663 BLAminus -137.57, -177.62 60.57, 72.93 -89.1, 20.04 274.87, 75.15 -57.71, -33.47 in-in in 9.285 Saltbr-in 2.891 HRD-in -83.52, -48.93 71.64, -3.16 in-in-out SNCiio in-out ActLoopNT-in 2.96 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -86.33, -81.37 APE9-dihe-na -105.19, -110.27 APE8-dihe-in -73.56, 134.57 APE8-rot-out 182.29 APE67-dihe-in -52.75, -29.28 -80.52, -6.55 APE12-dist-in 12.186 APE11-dist-in 10.955 APE10-dist-out 10.156 APE9-dist-out 11.376 None TPO288 TPO288 XRAY 2.15 0.191 0.23 A 285 265 0 0 0 0 [[133, 383]] 1.0 6r4b Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6R4CA O14965 127 391 403.0 ADP:501,JRQ:507 ATPlike,Allosteric Inactive DFGin 6.021 15.666 BLAminus -134.91, -179.34 60.98, 67.5 -85.83, 17.59 275.41, 71.94 -60.31, -30.9 in-in in 9.068 Saltbr-in 2.769 HRD-in -80.73, -51.78 76.01, -7.95 in-in-out SNCiio in-out ActLoopNT-in 2.891 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -93.37, -96.1 APE9-dihe-na -98.19, -111.55 APE8-dihe-in -67.65, 142.09 APE8-rot-out 185.03 APE67-dihe-in -56.49, -28.95 -89.55, -1.14 APE12-dist-in 12.192 APE11-dist-in 10.889 APE10-dist-out 9.931 APE9-dist-out 11.395 C290A,C393A TPO288 TPO288 XRAY 2.04 0.188 0.226 A 285 265 0 0 0 0 [[133, 383]] 1.0 6r4c Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6R4DA O14965 127 391 403.0 ADP:501,JRW:505 ATPlike,Allosteric Inactive DFGin 5.413 15.061 BLAminus -136.32, -175.95 60.26, 82.3 -97.39, 21.73 280.16, 71.96 -61.32, -30.02 in-in in 9.377 Saltbr-in 2.936 HRD-in -84.35, -49.77 70.9, 2.54 in-in-out SNCiio in-out ActLoopNT-in 2.898 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -109.88, -49.72 APE9-dihe-na -75.41, -134.11 APE8-dihe-in -89.35, 144.76 APE8-rot-out 181.5 APE67-dihe-in -55.31, -28.98 -80.38, -7.16 APE12-dist-in 12.169 APE11-dist-in 10.39 APE10-dist-out 11.478 APE9-dist-out 10.589 C290A,C393A TPO288 TPO288 XRAY 2.009 0.197 0.233 A 285 265 0 0 0 0 [[133, 383]] 1.0 6r4d Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 7ZTLA O14965 126 389 403.0 ADP:501,BCN:506 ATPlike,Allosteric Active DFGin 5.623 15.108 BLAminus -131.55, 179.55 58.91, 75.38 -87.97, 22.52 281.42, 69.29 -65.3, -21.25 in-in in 9.225 Saltbr-in 2.815 HRD-in -81.87, -52.88 75.2, 3.05 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.79, 177.44 APE9-dihe-na 70.08, -157.96 APE8-dihe-in -126.05, 125.84 APE8-rot-in 309.73 APE67-dihe-in -58.88, -23.16 -51.84, -48.56 APE12-dist-in 8.126 APE11-dist-in 10.601 APE10-dist-in 5.354 APE9-dist-in 3.765 C290A,K339C,C393A TPO288 TPO288 XRAY 1.9 0.165 0.193 A 309 264 0 0 0 0 [[133, 383]] 1.0 7ztl Homo sapiens CAMK_AURKA_HUMAN CAMK 4.2e-78 268.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8OF5A O14965 126 390 403.0 ADP:501,MPO:505 ATPlike,Allosteric Inactive DFGin 5.561 15.073 BLAminus -147.6, 177.58 63.9, 71.93 -82.69, 26.74 280.62, 72.05 -50.28, -40.53 in-in in 9.376 Saltbr-in 2.739 HRD-in -82.42, -53.84 70.6, 7.86 in-in-out SNCiio in-out ActLoopNT-in 2.987 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na 65.3, 47.54 APE9-dihe-na -68.67, -176.82 APE8-dihe-in -69.15, 145.4 APE8-rot-out 54.1 APE67-dihe-in -51.26, -26.94 -88.64, -16.45 APE12-dist-out 18.239 APE11-dist-out 20.587 APE10-dist-out 23.612 APE9-dist-out 27.905 C290A,N332A,Q335A,C393A None None XRAY 1.97 0.186 0.235 A 285 265 0 0 0 0 [[133, 383]] 1.0 8of5 Homo sapiens CAMK_AURKA_HUMAN CAMK 3.1e-78 268.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C14A O14965 126 389 403.0 ADP:417,T5L:418,T0L:424 ATPlike,Allosteric,Allosteric Inactive DFGin 5.631 14.794 BLAminus -132.92, -178.64 59.29, 78.11 -87.91, 19.69 280.37, 75.08 -49.0, -40.94 in-in in 9.323 Saltbr-in 2.749 HRD-in -74.47, -52.26 68.72, 1.37 in-in-out SNCiio in-out ActLoopNT-in 2.823 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -125.05, 2.89 APE9-dihe-na -76.04, 173.54 APE8-dihe-in -47.98, 133.45 APE8-rot-in 311.24 APE67-dihe-in -48.21, -32.08 -100.5, -9.07 APE12-dist-in 9.082 APE11-dist-in 13.03 APE10-dist-out 15.593 APE9-dist-out 10.893 None TPO288 TPO288 XRAY 1.93 0.182 0.194 A 272 264 0 0 0 0 [[133, 383]] 1.0 8c14 Homo sapiens CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C15A O14965 126 388 403.0 ADP:401,T4C:404,T5L:405 ATPlike,Allosteric,Allosteric Inactive DFGin 5.658 14.941 BLAminus -128.39, 176.76 57.21, 80.94 -90.54, 19.4 280.16, 77.64 -46.89, -42.14 in-in in 9.356 Saltbr-in 2.912 HRD-in -70.87, -48.88 65.09, -5.38 in-in-out SNCiio in-out ActLoopNT-in 2.848 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -170.75 APE8-dihe-in -66.3, 161.07 APE8-rot-out 73.39 APE67-dihe-in -37.43, -35.12 -85.37, -6.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.144 C290A None None XRAY 2.41 0.199 0.207 A 265 259 4 0 0 4 [[133, 383]] 1.0 8c15 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1FA O14965 126 388 403.0 ADP:401,T5L:409,T2O:417 ATPlike,Allosteric,Allosteric Inactive DFGin 5.472 14.634 BLAminus -130.51, -175.69 56.68, 77.24 -89.7, 19.52 279.6, 79.65 -52.03, -32.93 in-in in 9.302 Saltbr-in 2.811 HRD-in -73.98, -48.91 69.8, -1.54 in-in-out SNCiio in-out ActLoopNT-in 2.877 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -138.04 APE8-dihe-in -67.54, 164.12 APE8-rot-out 77.8 APE67-dihe-in -44.07, -35.33 -85.42, 0.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.522 C290A None None XRAY 1.924 0.206 0.234 A 265 258 5 0 0 5 [[133, 383]] 1.0 8c1f Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1IA O14965 126 388 403.0 ADP:401,T1L:404,T5L:405 ATPlike,Allosteric,Allosteric Inactive DFGin 5.524 14.838 BLAminus -129.39, -179.52 57.08, 78.15 -89.88, 20.87 280.11, 76.95 -51.9, -37.66 in-in in 9.355 Saltbr-in 2.906 HRD-in -72.05, -49.31 67.09, -4.7 in-in-out SNCiio in-out ActLoopNT-in 2.821 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -172.24 APE8-dihe-in -59.73, 161.33 APE8-rot-out 79.24 APE67-dihe-in -39.82, -36.32 -87.05, -1.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.341 C290A None None XRAY 2.81 0.213 0.234 A 265 260 3 0 0 3 [[133, 383]] 1.0 8c1i Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1MA O14965 127 389 403.0 T4X:402,ADP:404 Allosteric,ATPlike Inactive DFGin 5.6 15.272 BLAminus -122.0, 174.82 64.71, 68.72 -82.42, 30.82 279.23, 73.39 -59.87, -38.7 in-in in 9.647 Saltbr-in 3.053 HRD-in -66.75, -51.37 63.02, 9.93 in-in-out SNCiio in-out ActLoopNT-in 2.895 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -144.61, 52.2 APE9-dihe-na -98.47, -158.53 APE8-dihe-in -77.97, 114.41 APE8-rot-out 83.32 APE67-dihe-in -36.94, -36.23 -77.28, -23.95 APE12-dist-in 9.528 APE11-dist-in 12.989 APE10-dist-out 15.755 APE9-dist-out 10.619 None TPO288 TPO288 XRAY 2.84 0.253 0.269 A 273 263 0 0 0 0 [[133, 383]] 1.0 8c1m Homo sapiens CAMK_AURKA_HUMAN CAMK 6.5e-80 274.0 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1DA O14965 127 388 403.0 T2F:401,ADP:402,T5L:405 Allosteric,ATPlike,Allosteric Inactive DFGin 5.59 14.77 BLAminus -129.39, 179.64 57.3, 80.97 -92.88, 23.53 280.13, 79.47 -56.16, -33.44 in-in in 9.306 Saltbr-in 2.936 HRD-in -72.1, -50.49 67.69, -1.24 in-in-out SNCiio in-out ActLoopNT-in 2.796 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 144.85 APE8-dihe-in -64.26, 154.27 APE8-rot-out 88.6 APE67-dihe-in -39.49, -36.75 -82.32, -6.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.088 C290A None None XRAY 2.115 0.212 0.238 A 265 259 3 0 0 3 [[133, 383]] 1.0 8c1d Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1GA O14965 127 388 403.0 T3I:401,ADP:402,T5L:406 Allosteric,ATPlike,Allosteric Inactive DFGin 5.544 14.882 BLAminus -128.11, -179.39 58.87, 76.11 -85.79, 22.41 279.68, 78.85 -51.87, -42.67 in-in in 9.223 Saltbr-in 2.92 HRD-in -78.13, -46.93 64.28, -1.01 in-in-out SNCiio in-out ActLoopNT-in 2.859 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -158.88 APE8-dihe-in -70.7, 159.97 APE8-rot-out 74.34 APE67-dihe-in -36.07, -37.71 -84.84, -3.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.355 C290A None None XRAY 1.96 0.2 0.225 A 265 258 4 0 0 4 [[133, 383]] 1.0 8c1g Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1HA O14965 127 388 403.0 T3U:401,ADP:402,T5L:405 Allosteric,ATPlike,Allosteric Inactive DFGin 5.603 14.806 BLAminus -133.2, 171.3 67.89, 80.13 -90.96, 20.95 279.09, 80.15 -47.86, -43.49 in-in in 9.274 Saltbr-in 3.002 HRD-in -69.34, -50.65 67.03, -6.54 in-in-out SNCiio in-out ActLoopNT-in 2.865 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -157.54 APE8-dihe-in -70.83, 158.42 APE8-rot-out 74.14 APE67-dihe-in -36.91, -39.82 -81.98, -5.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.528 C290A None None XRAY 2.233 0.213 0.245 A 265 258 4 0 0 4 [[133, 383]] 1.0 8c1h Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1KA O14965 127 388 403.0 T4O:401,ADP:402,T5L:405 Allosteric,ATPlike,Allosteric Inactive DFGin 5.397 14.797 BLAminus -136.92, -175.3 58.28, 79.92 -93.28, 13.0 269.57, 89.35 -50.4, -38.71 in-in in 9.603 Saltbr-in 3.114 HRD-in -64.38, -56.58 69.39, -9.24 in-in-out SNCiio in-out ActLoopNT-in 3.009 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na 39.31, -114.48 APE9-dihe-na 117.85, -67.49 APE8-dihe-in -136.08, 128.66 APE8-rot-out 19.12 APE67-dihe-in -37.03, -29.23 -73.31, -14.52 APE12-dist-in 9.258 APE11-dist-in 12.914 APE10-dist-out 12.688 APE9-dist-out 10.835 C290A None None XRAY 2.43 0.219 0.242 A 273 262 0 0 0 0 [[133, 383]] 1.0 8c1k Homo sapiens CAMK_AURKA_HUMAN CAMK 8e-79 270.5 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8PR7D O14965 126 388 403.0 ADP:501 ATPlike Inactive DFGin 6.916 17.682 BLBminus -119.47, -172.43 57.55, 67.82 -98.5, 138.77 288.48, 69.88 152.2, -37.73 out-none out 11.781 Saltbr-none 999.0 HRD-in -89.57, -45.69 63.63, 4.27 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, 178.01 APE9-dihe-na 51.17, 13.86 APE8-dihe-out -88.74, -9.17 APE8-rot-none 999.0 APE67-dihe-in -65.89, -30.04 -136.83, 2.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.929 APE9-dist-out 11.396 D274N,C290A,N332A,Q335A,T347A,D350A,C393A None None XRAY 2.76 0.205 0.256 D 283 251 12 0 0 12 [[133, 383]] 1.0 8pr7 Homo sapiens CAMK_AURKA_HUMAN CAMK 3e-77 265.4 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ODTA O14965 126 392 403.0 ADP:501 ATPlike Inactive DFGin 6.717 16.96 None -121.13, 4.47 -111.78, 32.81 -79.52, 164.76 286.94, 96.78 78.48, -128.28 out-out out 11.748 Saltbr-out 10.767 HRD-out -137.93, 83.59 -73.55, -34.72 out-out-out SNCooo out-out ActLoopNT-out 17.788 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, -15.28 APE9-dihe-na -98.55, 177.35 APE8-dihe-out 65.78, -46.63 APE8-rot-none 999.0 APE67-dihe-in -47.55, -29.4 -45.89, -32.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 24.867 APE9-dist-out 13.437 D274N,C290A,C393A None None XRAY 2.021 0.179 0.211 A 283 258 9 0 0 9 [[133, 383]] 1.0 5odt Homo sapiens CAMK_AURKA_HUMAN CAMK 5.4e-78 267.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 9GUCA O14965 124 391 403.0 ADP:501,AMP:503 ATPlike,Allosteric Inactive DFGin 7.177 17.543 None -98.47, -53.8 -99.76, 123.69 -123.57, 999.0 272.41, 116.36 999.0, 999.0 out-none out 10.881 Saltbr-none 999.0 HRD-in -77.17, -58.19 77.29, 1.39 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na -78.2, -27.21 APE9-dihe-na 141.47, -167.5 APE8-dihe-in -95.93, 123.55 APE8-rot-in 299.51 APE67-dihe-in -57.72, -20.14 -51.84, -47.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.708 C290A,C393A None None XRAY 2.1 0.193 0.232 A 285 256 12 0 0 12 [[133, 383]] 1.0 9guc Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5L8JA O14965 126 391 403.0 ADP:60501 ATPlike Inactive DFGinter 6.039 8.812 None -121.42, -0.81 -92.81, -3.45 60.99, 19.44 297.14, 26.84 -77.84, 60.22 out-out out 13.201 Saltbr-out 9.588 HRD-out -100.39, 154.9 -77.66, -154.82 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 16.48 APE8-rot-out 62.75 APE67-dihe-in -57.65, -20.32 -54.21, -40.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C290A,C393A TPO288 TPO288 XRAY 1.68 0.201 0.231 A 285 253 13 0 0 13 [[133, 383]] 1.0 5l8j Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5L8KA O14965 126 392 403.0 ADP:60501 ATPlike Inactive DFGinter 5.934 8.696 None -123.53, 3.87 -94.88, 4.13 51.12, 25.43 307.6, 8.65 -83.23, 69.32 out-out out 12.906 Saltbr-out 9.137 HRD-out -94.24, 154.96 -82.75, -161.39 out-out-out SNCooo out-out ActLoopNT-out 5.262 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -60.54, 152.13 APE9-dihe-na 121.57, -104.82 APE8-dihe-in -138.45, 120.03 APE8-rot-in 300.38 APE67-dihe-in -56.47, -22.96 -75.46, -21.38 APE12-dist-out 14.19 APE11-dist-out 17.885 APE10-dist-out 19.722 APE9-dist-out 13.729 C290A,C393A TPO288 TPO288 XRAY 1.79 0.192 0.235 A 285 267 0 0 0 0 [[133, 383]] 1.0 5l8k Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5L8LA O14965 126 389 403.0 ADP:60501 ATPlike Inactive DFGinter 5.647 8.882 None -117.8, 6.57 -92.89, -1.12 53.22, 20.44 289.58, 36.26 -84.0, 68.46 out-out out 12.54 Saltbr-out 9.027 HRD-out -99.09, 148.91 -94.35, -164.8 out-out-out SNCooo out-out ActLoopNT-out 5.393 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -75.26, -165.41 APE9-dihe-na -67.89, -63.26 APE8-dihe-out -124.39, -179.64 APE8-rot-out 64.28 APE67-dihe-in -57.8, -26.84 -83.02, -0.31 APE12-dist-in 11.109 APE11-dist-out 16.52 APE10-dist-out 14.491 APE9-dist-out 14.639 C290A,C393A TPO288 TPO288 XRAY 1.67 0.193 0.223 A 285 264 0 0 0 0 [[133, 383]] 1.0 5l8l Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8PR7A O14965 124 389 403.0 ADP:501 ATPlike Inactive DFGinter 5.07 10.273 None -105.95, 148.75 -124.79, 28.7 -129.06, 999.0 303.51, 120.23 999.0, 999.0 out-out out 12.482 Saltbr-out 11.706 HRD-out 52.78, 71.6 -97.43, 142.22 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 47.95, -115.05 APE9-dihe-na -125.01, 9.37 APE8-dihe-out -40.29, -50.01 APE8-rot-out 85.86 APE67-dihe-in -55.11, -34.07 -62.49, -38.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.832 D274N,C290A,N332A,Q335A,T347A,D350A,C393A None None XRAY 2.76 0.205 0.256 A 283 253 13 0 0 13 [[133, 383]] 1.0 8pr7 Homo sapiens CAMK_AURKA_HUMAN CAMK 3e-77 265.4 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2WQEA O14965 127 388 403.0 ADP:1389,ADP:1390,ADP:1391 ATPlike,ATPlike,ATPlike Inactive None 999.0 999.0 None -107.12, -44.35 28.24, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 12.428 Saltbr-none 999.0 HRD-out -82.99, 160.23 -97.32, -44.1 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -56.47 APE8-dihe-out -79.62, -22.51 APE8-rot-in 267.0 APE67-dihe-in -40.62, -26.16 -46.48, -55.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.796 S155R None None XRAY 2.5 0.206 0.251 A 262 241 21 0 0 16 [[133, 383]] 1.0 2wqe Homo sapiens CAMK_AURKA_HUMAN CAMK 9.7e-80 273.5 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK CAMK2A KCC2A_HUMAN 7UJSA Q9UQM7 7 274 478.0 ADP:301 ATPlike Active DFGin 6.209 15.164 BLAminus -142.86, -173.92 52.2, 80.06 -100.62, 24.47 291.74, 81.6 -63.11, -26.23 in-in in 9.512 Saltbr-in 3.444 HRD-in -76.47, -52.69 80.52, -7.0 in-in-in SNCiii in-in ActLoopNT-in 2.952 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.88, 140.41 APE9-dihe-na 133.49, -148.09 APE8-dihe-in -128.43, 117.33 APE8-rot-in 305.05 APE67-dihe-in -59.07, -26.67 -36.29, -54.08 APE12-dist-in 10.197 APE11-dist-in 11.505 APE10-dist-in 5.779 APE9-dist-in 3.683 Q223K None None XRAY 2.75 0.201 0.262 A 268 268 0 0 0 0 [[13, 271]] 1.0 7ujs Homo sapiens CAMK_CAMK2A_HUMAN CAMK 1e-96 329.1 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 7UJPA Q9UQM7 7 274 478.0 ADP:301 ATPlike Active DFGin 6.775 14.64 BLAminus -129.88, 174.11 65.35, 73.67 -96.28, 29.41 284.7, 81.79 -65.3, -26.47 in-in in 8.527 Saltbr-in 2.903 HRD-in -76.38, -51.72 77.74, -11.0 in-in-in SNCiii in-in ActLoopNT-in 2.875 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.94, 142.69 APE9-dihe-na 139.08, -169.53 APE8-dihe-in -115.65, 123.25 APE8-rot-in 308.77 APE67-dihe-in -69.44, -15.11 -33.38, -56.34 APE12-dist-in 10.469 APE11-dist-in 11.397 APE10-dist-in 5.657 APE9-dist-in 3.521 D135N,Q223K None None XRAY 2.56 0.234 0.281 A 268 268 0 0 0 0 [[13, 271]] 1.0 7ujp Homo sapiens CAMK_CAMK2A_HUMAN CAMK 9.3e-96 326.0 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CHEK2 CHK2_HUMAN 2CN5A O96017 209 504 543.0 ADP:61509 ATPlike Inactive DFGin 6.789 14.494 BLAminus -135.2, 179.16 64.2, 79.37 -102.1, 20.75 283.06, 77.6 -58.46, -25.36 in-out in 9.917 Saltbr-out 4.344 HRD-in -79.96, -48.23 69.59, 1.14 out-in-out SNCoio in-out ActLoopNT-in 2.848 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -76.74, 7.44 APE9-dihe-na -76.93, 179.76 APE8-dihe-out 76.66, 47.76 APE8-rot-out 216.78 APE67-dihe-in -44.78, -36.74 -82.05, -7.37 APE12-dist-out 25.363 APE11-dist-out 27.519 APE10-dist-out 29.872 APE9-dist-out 32.768 None None None XRAY 2.25 0.201 0.24 A 329 282 14 0 0 0 [[220, 486]] 1.0 2cn5 Homo sapiens CAMK_CHEK2_HUMAN CAMK 2.1e-85 292.1 1 256 256 367 368 369 371 373 249 273 277 344 346 345 347 409 394 389 388 387 386 385 384 383 302 Serine/threonine-protein kinase Chk2
CAMK DAPK1 DAPK1_HUMAN 2W4JA P53355 2 277 1430.0 ADP:1278 ATPlike Inactive DFGin 6.586 13.895 BLAminus -123.3, -175.29 63.17, 81.91 -95.29, 20.87 287.95, 79.94 -69.92, -15.2 in-in in 8.992 Saltbr-in 2.745 HRD-in -74.79, -47.39 66.71, 11.49 in-in-out SNCiio in-out ActLoopNT-in 2.931 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -155.28, 112.88 APE9-dihe-na -96.93, -134.15 APE8-dihe-in -90.19, 126.44 APE8-rot-in 297.68 APE67-dihe-in -65.36, -18.9 -46.88, -44.63 APE12-dist-in 10.357 APE11-dist-out 6.539 APE10-dist-out 9.665 APE9-dist-in 4.992 None None None XRAY 1.3 0.132 0.159 A 277 276 0 0 0 0 [[13, 275]] 1.0 2w4j Homo sapiens CAMK_DAPK1_HUMAN CAMK 4.9e-95 323.6 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3EH9A P53355 2 277 1430.0 ADP:60001 ATPlike Inactive DFGin 6.72 14.106 BLAminus -121.08, 178.11 65.97, 83.53 -97.47, 22.9 284.12, 79.86 -68.8, -21.44 in-in in 9.515 Saltbr-in 3.088 HRD-in -77.18, -44.06 68.03, 9.36 in-in-out SNCiio in-out ActLoopNT-in 2.899 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -93.65, 114.44 APE9-dihe-na -90.95, -143.91 APE8-dihe-in -83.41, 125.11 APE8-rot-in 299.02 APE67-dihe-in -61.0, -22.55 -46.4, -40.51 APE12-dist-in 11.177 APE11-dist-out 5.772 APE10-dist-out 9.457 APE9-dist-in 4.556 None None None XRAY 1.7 0.18 0.217 A 294 274 2 0 0 0 [[13, 275]] 1.0 3eh9 Homo sapiens CAMK_DAPK1_HUMAN CAMK 6.1e-95 323.3 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3F5GA P53355 2 277 1430.0 ADP:60001 ATPlike Inactive DFGin 6.685 13.968 BLAminus -120.45, 179.24 65.08, 83.1 -97.05, 24.31 287.76, 77.76 -68.45, -21.11 in-in in 9.307 Saltbr-in 2.797 HRD-in -76.76, -45.85 68.91, 8.76 in-in-out SNCiio in-out ActLoopNT-in 2.914 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -92.45, 115.11 APE9-dihe-na -89.86, -138.22 APE8-dihe-in -85.51, 124.34 APE8-rot-in 301.38 APE67-dihe-in -61.82, -27.25 -45.2, -42.29 APE12-dist-in 11.024 APE11-dist-out 5.774 APE10-dist-out 9.48 APE9-dist-in 4.623 None None None XRAY 1.85 0.188 0.244 A 294 276 0 0 0 0 [[13, 275]] 1.0 3f5g Homo sapiens CAMK_DAPK1_HUMAN CAMK 6.1e-95 323.3 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 2W4KA P53355 2 302 1430.0 ADP:1303 ATPlike Active DFGin 6.672 14.178 BLAminus -119.76, -176.11 66.35, 79.87 -97.37, 22.41 282.66, 74.96 -63.58, -22.08 in-in in 9.11 Saltbr-in 2.829 HRD-in -72.34, -46.15 68.63, 4.94 in-in-in SNCiii in-in ActLoopNT-in 2.866 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.51, 175.21 APE9-dihe-na 86.37, -178.83 APE8-dihe-in -92.32, 120.41 APE8-rot-in 301.2 APE67-dihe-in -65.94, -16.49 -43.92, -47.7 APE12-dist-in 9.204 APE11-dist-in 12.288 APE10-dist-in 6.82 APE9-dist-in 5.132 None None None XRAY 1.9 0.195 0.228 A 302 301 0 0 0 0 [[13, 275]] 1.0 2w4k Homo sapiens CAMK_DAPK1_HUMAN CAMK 6.8e-95 323.2 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3GU6A P53355 2 277 1430.0 ADP:60296 ATPlike Inactive DFGin 6.703 14.015 BLAminus -123.16, -179.19 61.96, 78.37 -92.65, 24.29 287.26, 76.41 -68.7, -18.31 in-in in 9.083 Saltbr-in 2.722 HRD-in -78.16, -47.73 70.74, 4.81 in-in-out SNCiio in-out ActLoopNT-in 2.917 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -153.98, 117.17 APE9-dihe-na -91.62, -149.81 APE8-dihe-in -81.71, 126.34 APE8-rot-in 293.82 APE67-dihe-in -55.19, -26.27 -45.69, -42.2 APE12-dist-in 10.008 APE11-dist-out 6.601 APE10-dist-out 9.418 APE9-dist-in 4.349 Q23V None None XRAY 1.49 0.185 0.213 A 295 276 0 0 0 0 [[13, 275]] 1.0 3gu6 Homo sapiens CAMK_DAPK1_HUMAN CAMK 2.1e-94 321.5 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3GU7A P53355 2 277 1430.0 ADP:60296 ATPlike Inactive DFGin 6.697 14.121 BLAminus -119.64, -175.75 62.96, 82.16 -94.9, 24.89 284.57, 77.57 -70.06, -20.41 in-in in 9.248 Saltbr-in 2.787 HRD-in -79.97, -44.14 64.75, 4.23 in-in-out SNCiio in-out ActLoopNT-in 2.943 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -162.1, 115.0 APE9-dihe-na -94.82, -140.46 APE8-dihe-in -83.81, 124.48 APE8-rot-in 298.21 APE67-dihe-in -60.5, -27.71 -46.69, -42.88 APE12-dist-in 11.2 APE11-dist-out 6.383 APE10-dist-out 9.438 APE9-dist-in 4.626 Q23V None None XRAY 1.9 0.173 0.228 A 295 276 0 0 0 0 [[13, 275]] 1.0 3gu7 Homo sapiens CAMK_DAPK1_HUMAN CAMK 2.1e-94 321.5 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 2XUUA P53355 2 302 1430.0 ADP:1303 ATPlike Active DFGin 6.814 14.3 BLAminus -117.01, 179.93 67.97, 81.82 -97.7, 27.63 286.42, 73.81 -75.99, -13.96 in-in in 9.047 Saltbr-in 2.623 HRD-in -76.48, -45.49 71.86, 3.84 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -168.39, 167.91 APE9-dihe-na 89.82, 178.63 APE8-dihe-in -101.18, 124.0 APE8-rot-in 296.23 APE67-dihe-in -60.21, -22.55 -44.54, -47.64 APE12-dist-in 8.87 APE11-dist-in 11.727 APE10-dist-in 6.406 APE9-dist-in 5.145 E182A None None XRAY 1.8 0.179 0.226 A 334 301 0 0 0 0 [[13, 275]] 1.0 2xuu Homo sapiens CAMK_DAPK1_HUMAN CAMK 1.4e-94 322.3 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK MAPKAPK2 MAPK2_HUMAN 1NY3A P49137 46 345 400.0 ADP:401 ATPlike Inactive DFGin 4.213 13.918 BLAminus -139.11, 173.49 82.65, 112.5 -121.18, 20.23 280.18, 65.28 -53.92, -18.87 out-out out 10.039 Saltbr-out 6.106 HRD-in -63.84, -48.41 55.55, 34.09 out-in-none SNCoin in-none ActLoopNT-in 2.981 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -47.32, -19.47 999.0, 98.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.27 0.292 A 400 277 23 0 0 9 [[63, 325]] 1.0 1ny3 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3 256 254 206 207 208 210 212 93 104 108 183 185 184 186 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK PASK PASK_HUMAN 3DLSA Q96RG2 982 1266 1323.0 ADP:1 ATPlike Active DFGin 6.001 14.204 BLAminus -129.0, 178.94 63.52, 79.16 -100.96, 27.03 282.44, 72.76 -70.92, -15.42 in-in in 8.655 Saltbr-in 2.605 HRD-na-E -71.55, -40.2 72.7, 1.22 in-in-in SNCiii in-in ActLoopNT-in 2.993 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.6, 5.88 APE9-dihe-na -96.65, -154.85 APE8-dihe-in -98.92, 122.93 APE8-rot-in 302.12 APE67-dihe-in -72.66, -14.95 -65.45, -19.89 APE12-dist-in 10.203 APE11-dist-in 10.574 APE10-dist-in 5.061 APE9-dist-in 3.451 None None None XRAY 2.3 0.244 0.297 A 335 285 0 0 0 0 [[999, 1251]] 1.0 3dls Homo sapiens CAMK_PASK_HUMAN CAMK 2.7e-67 232.8 1 256 256 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN 3DLSB Q96RG2 982 1267 1323.0 ADP:2 ATPlike Active DFGin 6.1 14.087 BLAminus -126.55, 179.43 61.31, 80.64 -98.16, 22.24 284.4, 71.69 -72.83, -6.95 in-in in 8.346 Saltbr-in 2.677 HRD-na-E -67.25, -43.38 72.94, 0.56 in-in-in SNCiii in-in ActLoopNT-in 2.921 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.86, 22.09 APE9-dihe-na -121.63, -155.86 APE8-dihe-in -97.56, 124.97 APE8-rot-in 306.83 APE67-dihe-in -68.7, -17.81 -61.84, -27.67 APE12-dist-in 10.243 APE11-dist-in 10.688 APE10-dist-in 5.149 APE9-dist-in 3.521 None None None XRAY 2.3 0.244 0.297 B 335 280 6 0 0 0 [[999, 1251]] 1.0 3dls Homo sapiens CAMK_PASK_HUMAN CAMK 2.7e-67 232.8 1 256 256 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN 3DLSC Q96RG2 982 1267 1323.0 ADP:3 ATPlike Active DFGin 6.549 14.136 BLAminus -121.24, -178.98 61.8, 81.93 -100.03, 24.34 279.06, 77.86 -70.4, -24.84 in-in in 8.286 Saltbr-in 2.707 HRD-na-E -75.53, -39.96 73.3, -0.15 in-in-in SNCiii in-in ActLoopNT-in 2.808 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -109.16, 23.96 APE9-dihe-na -111.98, -161.37 APE8-dihe-in -95.46, 124.23 APE8-rot-in 302.16 APE67-dihe-in -72.29, -18.02 -57.94, -30.36 APE12-dist-in 9.98 APE11-dist-in 10.437 APE10-dist-in 4.962 APE9-dist-in 3.466 None None None XRAY 2.3 0.244 0.297 C 335 281 5 0 0 0 [[999, 1251]] 1.0 3dls Homo sapiens CAMK_PASK_HUMAN CAMK 2.7e-67 232.8 1 256 256 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN 3DLSD Q96RG2 982 1266 1323.0 ADP:4 ATPlike Active DFGin 5.989 14.037 BLAminus -119.78, -174.43 57.15, 82.44 -96.61, 20.08 283.36, 68.59 -63.18, -13.75 in-in in 8.596 Saltbr-in 2.674 HRD-na-E -66.59, -43.13 75.45, -3.58 in-in-in SNCiii in-in ActLoopNT-in 2.812 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.17, 8.76 APE9-dihe-na -100.36, -154.44 APE8-dihe-in -94.34, 129.8 APE8-rot-in 309.84 APE67-dihe-in -63.24, -17.05 -59.73, -34.41 APE12-dist-in 10.579 APE11-dist-in 10.601 APE10-dist-in 5.212 APE9-dist-in 3.318 None None None XRAY 2.3 0.244 0.297 D 335 284 1 0 0 0 [[999, 1251]] 1.0 3dls Homo sapiens CAMK_PASK_HUMAN CAMK 2.7e-67 232.8 1 256 256 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN 3DLSE Q96RG2 982 1267 1323.0 ADP:5 ATPlike Active DFGin 6.351 14.113 BLAminus -115.03, 172.38 61.43, 82.92 -98.38, 26.76 287.19, 66.36 -61.94, -22.57 in-in in 8.272 Saltbr-in 3.015 HRD-na-E -64.64, -41.08 75.56, -14.47 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.8, 6.63 APE9-dihe-na -93.38, -160.98 APE8-dihe-in -92.63, 131.98 APE8-rot-in 304.09 APE67-dihe-in -71.09, -14.17 -58.49, -32.88 APE12-dist-in 10.767 APE11-dist-in 10.575 APE10-dist-in 5.072 APE9-dist-in 3.423 None None None XRAY 2.3 0.244 0.297 E 335 282 4 0 0 0 [[999, 1251]] 1.0 3dls Homo sapiens CAMK_PASK_HUMAN CAMK 2.7e-67 232.8 1 256 256 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN 3DLSF Q96RG2 982 1266 1323.0 ADP:6 ATPlike Active DFGin 6.208 14.428 BLAminus -120.86, -179.45 54.8, 74.61 -87.61, 27.75 280.29, 66.66 -72.72, -14.22 in-in in 8.492 Saltbr-in 2.879 HRD-na-E -64.59, -48.9 86.1, -8.79 in-in-in SNCiii in-in ActLoopNT-in 2.704 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.3, 4.74 APE9-dihe-na -89.15, -152.34 APE8-dihe-in -104.88, 132.7 APE8-rot-in 302.97 APE67-dihe-in -72.03, -17.52 -62.59, -27.45 APE12-dist-in 10.486 APE11-dist-in 10.547 APE10-dist-in 5.101 APE9-dist-in 3.284 None None None XRAY 2.3 0.244 0.297 F 335 281 4 0 0 0 [[999, 1251]] 1.0 3dls Homo sapiens CAMK_PASK_HUMAN CAMK 2.7e-67 232.8 1 256 256 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK STK17B ST17B_HUMAN 6QF4A O94768 18 308 372.0 ADP:405 ATPlike Inactive DFGin 6.252 14.589 BLAminus -138.0, 178.42 64.68, 88.16 -110.19, 27.69 285.51, 77.31 -64.42, -20.01 out-out out 10.293 Saltbr-out 4.396 HRD-in -72.0, -51.78 71.09, 16.02 out-in-out SNCoio in-out ActLoopNT-in 3.129 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioo APE10-dihe-na -151.1, 167.46 APE9-dihe-na 109.33, 178.09 APE8-dihe-in -61.1, 118.93 APE8-rot-in 322.5 APE67-dihe-in -69.8, -8.25 -54.96, -33.39 APE12-dist-none 999.0 APE11-dist-in 12.911 APE10-dist-out 10.081 APE9-dist-out 7.839 None None None XRAY 2.495 0.187 0.227 A 327 287 4 0 0 4 [[32, 293]] 1.0 6qf4 Homo sapiens CAMK_STK17B_HUMAN CAMK 1.4e-81 279.8 4 256 253 178 179 180 182 184 62 80 84 155 157 156 158 217 205 200 199 198 197 196 195 194 111 Serine/threonine-protein kinase 17B
CAMK STK17B ST17B_HUMAN 7Q7CA O94768 25 297 372.0 ADP:60402 ATPlike None DFGin 5.672 13.983 BLAminus -146.28, 174.77 69.66, 80.54 -103.01, 24.61 291.62, 86.01 -65.04, -13.43 in-in in 9.403 Saltbr-in 3.35 HRD-in -84.64, -49.74 76.32, -16.47 in-in-none SNCiin in-none ActLoopNT-in 3.297 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 143.13 APE8-rot-in 309.53 APE67-dihe-in -65.37, -16.14 -54.33, -43.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.85 0.21 0.238 A 327 265 8 0 0 8 [[32, 293]] 1.0 7q7c Homo sapiens CAMK_STK17B_HUMAN CAMK 1.4e-81 279.8 4 256 253 178 179 180 182 184 62 80 84 155 157 156 158 217 205 200 199 198 197 196 195 194 111 Serine/threonine-protein kinase 17B
CK1 CSNK1D KC1D_HUMAN 6RU7A P48730 3 294 415.0 ADP:60301 Type1.5_Back Active DFGin 6.392 15.125 BLAminus -134.23, -173.24 59.44, 80.86 -96.06, 22.96 285.76, 78.27 -62.92, -27.34 in-in in 7.971 Saltbr-in 2.803 HRD-in -82.18, -50.23 72.61, 5.15 in-in-in SNCiii in-in ActLoopNT-in 2.884 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.24, 126.6 APE9-dihe-na 114.96, -145.11 APE8-dihe-in -115.28, 122.22 APE8-rot-in 302.31 APE67-dihe-in -56.73, -38.36 -50.64, -46.9 APE12-dist-in 12.381 APE11-dist-in 12.179 APE10-dist-in 6.834 APE9-dist-in 3.511 None None None XRAY 2.08 0.177 0.218 A 296 292 0 0 0 0 [[9, 275]] 1.0 6ru7 Homo sapiens CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RU7B P48730 3 294 415.0 ADP:60301 Type1.5_Back Active DFGin 6.618 14.988 BLAminus -130.01, -176.4 60.72, 81.81 -97.28, 21.17 286.1, 78.89 -61.41, -29.58 in-in in 7.795 Saltbr-in 2.912 HRD-in -81.31, -50.84 72.75, 6.38 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.97, 131.36 APE9-dihe-na 113.79, -145.67 APE8-dihe-in -115.43, 125.17 APE8-rot-in 305.08 APE67-dihe-in -54.67, -36.6 -52.93, -49.24 APE12-dist-in 13.297 APE11-dist-in 12.156 APE10-dist-in 6.649 APE9-dist-in 3.527 None None None XRAY 2.08 0.177 0.218 B 296 288 4 0 0 4 [[9, 275]] 1.0 6ru7 Homo sapiens CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RU8A P48730 2 294 415.0 ADP:60301 Type1.5_Back Active DFGin 6.425 15.156 BLAminus -131.62, -177.15 63.45, 81.35 -98.16, 25.89 286.32, 78.16 -68.14, -23.3 in-in in 7.926 Saltbr-in 2.803 HRD-in -87.78, -47.56 70.02, 4.06 in-in-in SNCiii in-in ActLoopNT-in 2.84 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.49, 136.29 APE9-dihe-na 109.45, -154.85 APE8-dihe-in -109.19, 121.34 APE8-rot-in 302.42 APE67-dihe-in -58.68, -38.47 -55.68, -42.0 APE12-dist-in 13.563 APE11-dist-in 12.282 APE10-dist-in 6.892 APE9-dist-in 3.572 None None None XRAY 1.92 0.174 0.211 A 296 293 0 0 0 0 [[9, 275]] 1.0 6ru8 Homo sapiens CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RU8B P48730 2 294 415.0 ADP:60301 Type1.5_Back Active DFGin 6.591 15.264 BLAminus -131.67, -177.68 64.26, 82.5 -98.0, 23.89 285.39, 79.53 -66.54, -22.27 in-in in 7.662 Saltbr-in 2.78 HRD-in -88.75, -48.7 67.58, 11.08 in-in-in SNCiii in-in ActLoopNT-in 2.853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.47, 142.8 APE9-dihe-na 95.33, -164.73 APE8-dihe-in -102.94, 120.03 APE8-rot-in 301.71 APE67-dihe-in -59.39, -37.33 -59.11, -40.45 APE12-dist-in 12.308 APE11-dist-in 12.295 APE10-dist-in 7.245 APE9-dist-in 3.892 None None None XRAY 1.92 0.174 0.211 B 296 293 0 0 0 0 [[9, 275]] 1.0 6ru8 Homo sapiens CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RU8C P48730 2 294 415.0 ADP:60301 Type1.5_Back Active DFGin 6.558 14.983 BLAminus -128.29, -179.37 66.68, 80.46 -98.0, 22.92 288.66, 76.31 -64.33, -23.77 in-in in 7.948 Saltbr-in 2.77 HRD-in -82.99, -49.18 72.75, 4.46 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.59, 138.55 APE9-dihe-na 101.61, -152.03 APE8-dihe-in -108.82, 122.86 APE8-rot-in 298.47 APE67-dihe-in -58.74, -36.85 -58.82, -40.4 APE12-dist-in 13.04 APE11-dist-in 12.435 APE10-dist-in 6.868 APE9-dist-in 3.607 None None None XRAY 1.92 0.174 0.211 C 296 287 6 0 0 6 [[9, 275]] 1.0 6ru8 Homo sapiens CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RU8D P48730 2 294 415.0 ADP:60301 Type1.5_Back Active DFGin 6.534 14.975 BLAminus -126.38, -177.59 65.46, 80.95 -97.97, 21.9 288.13, 75.77 -63.86, -25.32 in-in in 7.979 Saltbr-in 2.782 HRD-in -86.34, -48.63 71.97, 3.09 in-in-in SNCiii in-in ActLoopNT-in 2.81 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.34, 138.88 APE9-dihe-na 102.71, -155.7 APE8-dihe-in -106.76, 124.41 APE8-rot-in 298.22 APE67-dihe-in -58.88, -36.36 -58.72, -41.76 APE12-dist-in 12.717 APE11-dist-in 12.352 APE10-dist-in 6.743 APE9-dist-in 3.59 None None None XRAY 1.92 0.174 0.211 D 296 293 0 0 0 0 [[9, 275]] 1.0 6ru8 Homo sapiens CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 TTBK1 TTBK1_HUMAN 4BTJA Q5TCY1 21 312 1321.0 ADP:61337 ATPlike Active DFGin 5.513 12.699 BLAminus -122.16, 167.53 65.74, 92.18 -107.62, 12.94 309.85, 113.04 -64.35, -28.29 in-in in 7.127 Saltbr-in 2.757 HRD-in -79.44, -52.71 73.3, -5.89 in-in-in SNCiii in-in ActLoopNT-in 2.821 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.78, 143.11 APE9-dihe-na 98.14, -168.76 APE8-dihe-in -84.14, 153.12 APE8-rot-in 322.08 APE67-dihe-in -60.57, -38.77 -75.21, -43.81 APE12-dist-in 11.388 APE11-dist-in 11.45 APE10-dist-in 5.945 APE9-dist-in 3.412 None None None XRAY 2.16 0.179 0.197 A 337 292 0 0 0 0 [[34, 295]] 1.0 4btj Homo sapiens CK1_TTBK1_HUMAN CK1 5.7e-105 356.4 1 262 262 175 176 177 179 181 63 77 81 151 153 152 154 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
CK1 TTBK2 TTBK2_HUMAN 6VRFA Q6IQ55 9 298 1244.0 ADP:301 ATPlike Active DFGin 5.354 13.116 BLAminus -121.29, 164.21 73.75, 82.24 -97.72, 13.38 304.67, 116.94 -64.06, -29.66 in-in in 7.214 Saltbr-in 2.751 HRD-in -77.1, -49.95 73.69, -4.56 in-in-in SNCiii in-in ActLoopNT-in 2.813 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.12, -30.06 APE9-dihe-na -84.65, -146.34 APE8-dihe-in -107.58, 129.44 APE8-rot-in 302.21 APE67-dihe-in -59.13, -37.2 -56.28, -42.66 APE12-dist-in 11.197 APE11-dist-in 11.387 APE10-dist-in 5.48 APE9-dist-in 3.784 None None None XRAY 1.5 0.175 0.209 A 299 287 3 0 0 0 [[21, 282]] 1.0 6vrf Homo sapiens CK1_TTBK2_HUMAN CK1 7.7e-104 352.6 1 262 262 162 163 164 166 168 50 64 68 138 140 139 141 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2
CK1 TTBK2 TTBK2_HUMAN 6VRFB Q6IQ55 9 298 1244.0 ADP:301 ATPlike Active DFGin 5.431 12.695 BLAminus -121.38, 163.64 74.07, 85.5 -102.64, 12.86 306.76, 116.33 -62.94, -32.7 in-in in 7.346 Saltbr-in 2.891 HRD-in -78.31, -51.54 73.55, 1.77 in-in-in SNCiii in-in ActLoopNT-in 2.86 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -109.78, -23.36 APE9-dihe-na -86.88, -149.11 APE8-dihe-in -108.63, 128.02 APE8-rot-in 302.45 APE67-dihe-in -58.2, -36.14 -56.96, -43.7 APE12-dist-in 11.039 APE11-dist-in 11.244 APE10-dist-in 5.337 APE9-dist-in 3.712 None None None XRAY 1.5 0.175 0.209 B 299 287 3 0 0 0 [[21, 282]] 1.0 6vrf Homo sapiens CK1_TTBK2_HUMAN CK1 7.7e-104 352.6 1 262 262 162 163 164 166 168 50 64 68 138 140 139 141 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2
CMGC CDK11B CD11B_HUMAN 9I9IK P21127 440 740 795.0 ADP:60801 ATPlike Inactive DFGin 4.763 14.146 BLAminus -158.41, -152.11 58.37, 65.02 -86.96, 23.61 281.98, 74.01 -65.45, -34.44 in-in in 9.348 Saltbr-in 3.025 HRD-in -87.02, -49.1 60.47, 15.99 in-in-out SNCiio in-out ActLoopNT-in 2.843 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -140.14, 178.62 APE9-dihe-na 67.65, 142.84 APE8-dihe-in -66.76, 156.24 APE8-rot-out 57.56 APE67-dihe-in -70.3, -10.82 -63.46, -38.5 APE12-dist-in 13.294 APE11-dist-in 11.398 APE10-dist-in 6.513 APE9-dist-in 3.289 None TPO595 TPO595 EM 3.5 999.0 999.0 K 442 268 35 0 0 6 [[438, 723]] 1.0 9i9i Homo sapiens CMGC_CDK11B_HUMAN CMGC 5.1e-79 271.6 1 301 301 579 580 581 583 585 467 485 489 559 561 560 562 620 607 602 601 600 599 598 597 596 517 Cyclin-dependent kinase 11B
CMGC CDK12 CDK12_HUMAN 4NSTA Q9NYV4 716 1046 1490.0 ADP:1101 ATPlike Inactive DFGin 6.978 15.111 BLAminus -127.54, 179.84 60.58, 76.06 -95.3, 23.79 283.73, 86.71 -65.43, -16.77 in-in in 8.988 Saltbr-in 3.031 HRD-in -82.28, -56.37 71.8, 9.39 in-in-out SNCiio in-out ActLoopNT-in 2.956 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -128.59, 153.12 APE9-dihe-na 76.09, 132.29 APE8-dihe-in -60.41, 149.83 APE8-rot-out 85.48 APE67-dihe-in -64.83, -28.79 -60.07, -39.7 APE12-dist-in 13.247 APE11-dist-in 11.273 APE10-dist-in 6.995 APE9-dist-in 3.461 None TPO893 TPO893 XRAY 2.2 0.198 0.24 A 351 323 8 0 0 0 [[727, 1020]] 1.0 4nst Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 4NSTC Q9NYV4 717 1045 1490.0 ADP:1101 ATPlike Inactive DFGin 6.972 15.168 BLAminus -122.49, -178.57 55.97, 75.42 -92.86, 20.68 283.24, 86.31 -56.98, -20.08 in-in in 8.863 Saltbr-in 2.957 HRD-in -69.12, -51.54 66.96, 15.75 in-in-out SNCiio in-out ActLoopNT-in 2.928 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.74, 152.42 APE9-dihe-na 82.09, 126.12 APE8-dihe-in -62.22, 152.62 APE8-rot-out 78.32 APE67-dihe-in -63.16, -30.08 -57.73, -42.25 APE12-dist-in 13.202 APE11-dist-in 11.267 APE10-dist-in 6.942 APE9-dist-in 3.705 None TPO893 TPO893 XRAY 2.2 0.198 0.24 C 351 318 11 0 0 1 [[727, 1020]] 1.0 4nst Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK13 CDK13_HUMAN 5EFQA Q14004 695 1025 1512.0 ADP:1101 ATPlike Inactive DFGin 6.755 15.589 BLAminus -141.88, 177.76 70.28, 48.66 -74.58, 17.49 278.28, 85.63 -61.09, -20.11 in-in in 8.116 Saltbr-in 2.814 HRD-in -86.6, -50.11 69.54, 11.28 in-in-out SNCiio in-out ActLoopNT-in 3.137 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -127.03, -45.46 APE9-dihe-na -90.96, 147.77 APE8-dihe-in -58.82, 149.25 APE8-rot-out 183.76 APE67-dihe-in -63.13, -14.28 -57.08, -47.49 APE12-dist-in 13.272 APE11-dist-in 11.121 APE10-dist-in 6.954 APE9-dist-in 3.353 None TPO871 TPO871 XRAY 2.0 0.197 0.247 A 347 322 9 0 0 0 [[705, 998]] 1.0 5efq Homo sapiens CMGC_CDK13_HUMAN CMGC 2.2e-85 292.5 1 301 301 854 855 856 858 860 734 752 756 834 836 835 837 896 883 878 877 876 875 874 873 872 792 Cyclin-dependent kinase 13
CMGC CDK13 CDK13_HUMAN 5EFQC Q14004 697 1031 1512.0 ADP:1101 ATPlike Inactive DFGin 6.671 15.396 BLAminus -141.53, 176.29 69.41, 51.5 -75.76, 17.57 280.54, 75.34 -60.62, -20.31 in-in in 8.109 Saltbr-in 2.945 HRD-in -87.13, -51.3 69.73, 13.1 in-in-out SNCiio in-out ActLoopNT-in 2.938 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -124.45, -44.56 APE9-dihe-na -90.13, 148.33 APE8-dihe-in -57.19, 149.29 APE8-rot-out 181.48 APE67-dihe-in -63.2, -13.36 -56.43, -47.06 APE12-dist-in 13.404 APE11-dist-in 11.586 APE10-dist-in 7.079 APE9-dist-in 3.345 None TPO871 TPO871 XRAY 2.0 0.197 0.247 C 347 326 9 0 0 0 [[705, 998]] 1.0 5efq Homo sapiens CMGC_CDK13_HUMAN CMGC 2.2e-85 292.5 1 301 301 854 855 856 858 860 734 752 756 834 836 835 837 896 883 878 877 876 875 874 873 872 792 Cyclin-dependent kinase 13
CMGC CDK2 CDK2_HUMAN 4I3ZA P24941 1 296 298.0 ADP:60301 ATPlike Active DFGin 6.408 15.148 BLAminus -137.57, -176.06 52.96, 75.44 -91.33, 19.91 280.72, 70.75 -64.88, -19.38 in-in in 8.599 Saltbr-in 2.988 HRD-in -80.76, -55.87 72.55, 4.85 in-in-in SNCiii in-in ActLoopNT-in 2.901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.11, -96.25 APE9-dihe-na -51.92, 142.27 APE8-dihe-in -55.11, 135.08 APE8-rot-in 307.48 APE67-dihe-in -54.58, -26.51 -40.4, -56.95 APE12-dist-in 13.064 APE11-dist-in 10.585 APE10-dist-in 6.823 APE9-dist-in 3.305 None TPO160 TPO160 XRAY 2.05 0.199 0.228 A 296 296 0 0 0 0 [[4, 286]] 1.0 4i3z Homo sapiens CMGC_CDK2_HUMAN CMGC 6.2e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4I3ZC P24941 1 296 298.0 ADP:60301 ATPlike Active DFGin 6.367 15.146 BLAminus -139.14, -175.0 51.64, 79.19 -95.11, 18.85 278.6, 70.91 -64.63, -17.11 in-in in 8.653 Saltbr-in 2.979 HRD-in -79.85, -55.96 72.81, 4.84 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.52, -96.18 APE9-dihe-na -52.61, 142.23 APE8-dihe-in -53.61, 133.4 APE8-rot-in 308.84 APE67-dihe-in -53.33, -28.57 -37.02, -58.54 APE12-dist-in 13.081 APE11-dist-in 10.618 APE10-dist-in 6.861 APE9-dist-in 3.305 None TPO160 TPO160 XRAY 2.05 0.199 0.228 C 296 296 0 0 0 0 [[4, 286]] 1.0 4i3z Homo sapiens CMGC_CDK2_HUMAN CMGC 6.2e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3QHRA P24941 1 296 298.0 ADP:60297 ATPlike Active DFGin 6.557 15.107 BLAminus -129.61, -176.27 55.27, 75.32 -97.07, 17.79 280.43, 72.68 -60.79, -23.59 in-in in 8.696 Saltbr-in 2.88 HRD-in -78.46, -57.59 71.9, 8.99 in-in-in SNCiii in-in ActLoopNT-in 2.877 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.99, 139.5 APE9-dihe-na 85.76, 129.74 APE8-dihe-in -56.31, 140.07 APE8-rot-in 302.24 APE67-dihe-in -65.07, -20.31 -41.24, -52.35 APE12-dist-in 12.989 APE11-dist-in 10.171 APE10-dist-in 7.111 APE9-dist-in 3.341 None TPO160 TPO160 XRAY 2.17 0.18 0.21 A 298 296 0 0 0 0 [[4, 286]] 1.0 3qhr Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3QHRC P24941 1 296 298.0 ADP:60297 ATPlike Active DFGin 6.565 15.121 BLAminus -133.25, -174.75 53.96, 72.74 -93.36, 15.91 281.14, 71.23 -60.56, -21.49 in-in in 8.7 Saltbr-in 2.868 HRD-in -78.47, -57.15 72.13, 9.85 in-in-in SNCiii in-in ActLoopNT-in 2.876 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.81, 147.52 APE9-dihe-na 81.05, 137.24 APE8-dihe-in -64.2, 137.48 APE8-rot-in 304.68 APE67-dihe-in -62.37, -22.27 -38.55, -53.11 APE12-dist-in 12.985 APE11-dist-in 10.232 APE10-dist-in 6.99 APE9-dist-in 3.293 None TPO160 TPO160 XRAY 2.17 0.18 0.21 C 298 296 0 0 0 0 [[4, 286]] 1.0 3qhr Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3QHWA P24941 1 296 298.0 ADP:60297 ATPlike Active DFGin 6.435 15.013 BLAminus -134.08, -174.07 54.44, 75.18 -91.31, 13.19 281.29, 72.4 -60.66, -23.16 in-in in 8.64 Saltbr-in 2.934 HRD-in -72.46, -52.11 70.84, 4.06 in-in-in SNCiii in-in ActLoopNT-in 2.903 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.61, -86.88 APE9-dihe-na -62.59, 147.47 APE8-dihe-in -61.56, 138.19 APE8-rot-in 297.56 APE67-dihe-in -60.69, -27.39 -44.54, -49.89 APE12-dist-in 12.995 APE11-dist-in 10.23 APE10-dist-in 6.782 APE9-dist-in 3.359 None TPO160 TPO160 XRAY 1.91 0.189 0.219 A 298 296 0 0 0 0 [[4, 286]] 1.0 3qhw Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3QHWC P24941 1 296 298.0 ADP:60297 ATPlike Active DFGin 6.453 15.083 BLAminus -135.33, -175.53 57.5, 71.73 -89.85, 9.67 280.79, 72.12 -55.86, -26.79 in-in in 8.617 Saltbr-in 2.896 HRD-in -73.76, -53.15 71.96, 3.16 in-in-in SNCiii in-in ActLoopNT-in 2.898 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.86, -80.28 APE9-dihe-na -65.52, 146.91 APE8-dihe-in -61.19, 139.69 APE8-rot-in 298.69 APE67-dihe-in -57.2, -28.53 -47.15, -50.79 APE12-dist-in 12.997 APE11-dist-in 10.133 APE10-dist-in 6.722 APE9-dist-in 3.361 None TPO160 TPO160 XRAY 1.91 0.189 0.219 C 298 296 0 0 0 0 [[4, 286]] 1.0 3qhw Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4II5A P24941 1 296 298.0 ADP:60301 ATPlike Active DFGin 6.295 15.275 BLAminus -136.76, -174.67 48.15, 75.69 -89.27, 15.07 281.74, 67.11 -54.49, -30.0 in-in in 8.675 Saltbr-in 2.898 HRD-in -77.95, -58.94 72.46, 5.93 in-in-in SNCiii in-in ActLoopNT-in 2.856 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.58, 147.66 APE9-dihe-na 74.72, 130.64 APE8-dihe-in -63.5, 139.49 APE8-rot-in 303.89 APE67-dihe-in -59.35, -27.46 -47.25, -50.52 APE12-dist-in 13.127 APE11-dist-in 10.372 APE10-dist-in 7.034 APE9-dist-in 3.344 None TPO160 TPO160 XRAY 2.15 0.2 0.226 A 298 296 0 0 0 0 [[4, 286]] 1.0 4ii5 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4II5C P24941 1 296 298.0 ADP:60301 ATPlike Active DFGin 6.289 15.288 BLAminus -134.89, -171.63 44.93, 79.89 -96.21, 16.02 275.02, 74.95 -60.79, -24.87 in-in in 8.666 Saltbr-in 2.94 HRD-in -77.09, -52.7 69.17, 3.7 in-in-in SNCiii in-in ActLoopNT-in 2.858 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.65, 138.88 APE9-dihe-na 85.57, 133.69 APE8-dihe-in -65.51, 139.86 APE8-rot-in 305.2 APE67-dihe-in -60.76, -27.54 -47.35, -49.81 APE12-dist-in 13.141 APE11-dist-in 10.382 APE10-dist-in 7.061 APE9-dist-in 3.387 None TPO160 TPO160 XRAY 2.15 0.2 0.226 C 298 296 0 0 0 0 [[4, 286]] 1.0 4ii5 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9I9JK P24941 6 284 298.0 ADP:60301 ATPlike Inactive DFGin 7.502 16.779 BLAminus -158.16, 171.41 58.55, 63.81 -89.46, 61.19 266.29, 72.56 161.2, 999.0 in-out in 9.119 Saltbr-out 5.255 HRD-in -89.48, -59.44 66.59, -3.23 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -47.83 APE8-dihe-out -98.29, 31.77 APE8-rot-out 77.96 APE67-dihe-in -64.85, -20.6 -65.62, -27.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.13 None None None EM 3.1 999.0 999.0 K 301 246 37 0 0 16 [[4, 286]] 1.0 9i9j Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9I9KK P24941 2 292 298.0 ADP:60301 ATPlike Inactive DFGin 7.302 15.906 BLAminus -142.34, -176.15 60.61, 65.17 -90.86, 48.23 288.67, 80.56 -88.9, -30.85 out-out out 10.486 Saltbr-out 5.65 HRD-in -65.4, -52.43 72.61, -10.3 out-in-out SNCoio in-out ActLoopNT-in 2.558 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -73.37, 146.13 APE9-dihe-na -115.04, 137.49 APE8-dihe-in -60.96, 144.59 APE8-rot-out 184.92 APE67-dihe-in -75.1, -11.28 -107.26, -12.43 APE12-dist-in 12.011 APE11-dist-in 8.187 APE10-dist-out 12.049 APE9-dist-out 7.548 None None None EM 2.4 999.0 999.0 K 301 276 15 0 0 0 [[4, 286]] 1.0 9i9k Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK7 CDK7_HUMAN 9I9IJ P50613 12 310 346.0 ADP:60401 ATPlike Inactive DFGin 6.598 15.148 BLAminus -154.26, -174.63 55.49, 63.23 -84.52, 21.08 280.13, 83.68 -62.16, -39.37 in-out in 8.62 Saltbr-out 4.724 HRD-in -68.87, -48.72 60.83, 9.92 out-in-out SNCoio in-out ActLoopNT-in 2.772 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -114.8, -59.65 APE9-dihe-na -71.54, 157.02 APE8-dihe-in -67.36, 161.57 APE8-rot-out 77.35 APE67-dihe-in -72.1, -35.43 -63.15, -31.03 APE12-dist-in 12.421 APE11-dist-in 11.24 APE10-dist-in 6.135 APE9-dist-in 3.716 None None None EM 3.5 999.0 999.0 J 391 294 5 0 0 0 [[12, 295]] 1.0 9i9i Homo sapiens CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 9I9JJ P50613 11 310 346.0 ADP:60401 ATPlike Inactive DFGin 7.046 15.511 BLAminus -142.62, -171.5 55.13, 63.56 -86.1, 20.41 278.63, 86.43 -73.48, -14.71 in-in in 8.475 Saltbr-in 3.262 HRD-in -63.57, -47.3 66.21, -0.54 in-in-out SNCiio in-out ActLoopNT-in 2.876 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -125.41, 160.15 APE9-dihe-na -72.91, 167.58 APE8-dihe-in -60.97, 159.12 APE8-rot-out 182.98 APE67-dihe-in -64.29, -19.96 -63.65, -26.45 APE12-dist-in 11.208 APE11-dist-out 5.341 APE10-dist-out 9.202 APE9-dist-in 4.033 None None None EM 3.1 999.0 999.0 J 391 290 10 0 0 5 [[12, 295]] 1.0 9i9j Homo sapiens CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 9I9KJ P50613 10 310 346.0 ADP:60401 ATPlike Inactive DFGin 6.867 15.16 BLAminus -144.56, -175.34 58.29, 64.88 -85.43, 20.68 280.65, 74.04 -68.51, -15.78 in-in in 8.403 Saltbr-in 3.423 HRD-in -66.35, -48.78 67.04, 4.57 in-in-out SNCiio in-out ActLoopNT-in 2.701 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -135.97, 162.75 APE9-dihe-na -69.89, 166.52 APE8-dihe-in -58.19, 147.77 APE8-rot-out 190.67 APE67-dihe-in -62.09, -25.1 -66.28, -24.83 APE12-dist-in 11.543 APE11-dist-out 5.948 APE10-dist-out 9.159 APE9-dist-in 3.891 None None None EM 2.4 999.0 999.0 J 391 301 0 0 0 0 [[12, 295]] 1.0 9i9k Homo sapiens CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CSNK2A1 CSK21_HUMAN 6Z19B P68400 2 329 391.0 ADP:401 ATPlike Active DFGin 7.399 16.102 BLAminus -106.47, -175.56 60.6, 79.25 -100.03, 20.37 297.28, 82.12 -73.41, -21.13 in-in in 8.717 Saltbr-in 2.8 HRD-in -71.6, -55.48 75.88, 3.64 in-in-in SNCiii in-in ActLoopNT-in 2.928 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.14, 153.25 APE9-dihe-na 78.4, 166.67 APE8-dihe-in -74.52, 152.52 APE8-rot-in 285.35 APE67-dihe-in -64.18, -23.8 -57.77, -45.77 APE12-dist-in 12.968 APE11-dist-in 10.993 APE10-dist-in 6.495 APE9-dist-in 3.591 None None None XRAY 1.47 0.19 0.221 B 328 328 0 0 0 0 [[39, 324]] 1.0 6z19 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.2e-69 240.7 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OQUB P68400 4 327 391.0 ADP:401 ATPlike Active DFGin 7.324 16.392 BLAminus -107.74, -171.87 52.49, 78.62 -101.36, 19.11 291.9, 83.91 -71.23, -12.83 in-in in 9.496 Saltbr-in 2.901 HRD-in -65.86, -46.78 65.2, 13.55 in-in-in SNCiii in-in ActLoopNT-in 2.895 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.87, 169.85 APE9-dihe-na 66.11, 165.52 APE8-dihe-in -87.57, 142.09 APE8-rot-in 294.71 APE67-dihe-in -65.28, -26.45 -36.1, -50.26 APE12-dist-in 12.592 APE11-dist-in 10.419 APE10-dist-in 6.089 APE9-dist-in 3.154 R21S None None XRAY 2.324 0.221 0.244 B 352 324 0 0 0 0 [[39, 324]] 1.0 5oqu Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5ORKB P68400 4 326 391.0 ADP:401 ATPlike Active DFGin 7.365 16.488 BLAminus -111.04, -174.54 54.53, 77.94 -96.47, 19.83 296.01, 82.36 -66.2, -23.13 in-in in 9.552 Saltbr-in 3.041 HRD-in -70.69, -49.04 67.52, 16.07 in-in-in SNCiii in-in ActLoopNT-in 2.862 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.56, 172.18 APE9-dihe-na 65.73, 167.16 APE8-dihe-in -89.89, 143.95 APE8-rot-in 298.57 APE67-dihe-in -64.35, -23.63 -31.56, -56.57 APE12-dist-in 12.614 APE11-dist-in 10.418 APE10-dist-in 6.062 APE9-dist-in 3.149 R21S None None XRAY 2.143 0.217 0.243 B 352 323 0 0 0 0 [[39, 324]] 1.0 5ork Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7QUXA P68400 2 329 391.0 ADP:60401 ATPlike Active DFGin 7.585 16.194 BLAminus -111.52, -172.63 60.82, 80.19 -104.84, 23.49 298.85, 85.23 -72.93, -20.15 in-in in 8.958 Saltbr-in 2.838 HRD-in -72.19, -52.24 72.27, 9.35 in-in-in SNCiii in-in ActLoopNT-in 2.846 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.66, 178.74 APE9-dihe-na 61.29, -172.26 APE8-dihe-in -113.53, 144.19 APE8-rot-in 304.18 APE67-dihe-in -65.08, -18.11 -36.49, -57.4 APE12-dist-in 12.723 APE11-dist-in 10.579 APE10-dist-in 6.214 APE9-dist-in 2.896 None SEP2 SEP2 XRAY 1.48 0.181 0.204 A 352 328 0 0 0 0 [[39, 324]] 1.0 7qux Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6YZHA P68400 3 329 391.0 ADP:60403 ATPlike Active DFGin 7.386 16.31 BLAminus -108.01, -176.38 61.1, 79.34 -99.78, 17.26 297.37, 82.49 -78.41, -8.16 in-in in 9.131 Saltbr-in 2.829 HRD-in -74.51, -47.7 69.86, 14.14 in-in-in SNCiii in-in ActLoopNT-in 2.883 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.83, 175.48 APE9-dihe-na 62.95, -168.81 APE8-dihe-in -126.52, 135.38 APE8-rot-in 299.93 APE67-dihe-in -66.68, -18.66 -34.87, -54.46 APE12-dist-in 12.682 APE11-dist-in 10.343 APE10-dist-in 6.227 APE9-dist-in 3.084 None None None XRAY 1.19 0.173 0.19 A 398 327 0 0 0 0 [[39, 324]] 1.0 6yzh Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 2.4e-69 239.8 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6YPNB P68400 2 327 391.0 ADP:401,ADP:403 ATPlike,Allosteric Active DFGin 7.497 16.139 BLAminus -109.68, -177.56 60.98, 76.07 -97.07, 19.64 297.88, 85.05 -61.67, -35.53 in-in in 8.808 Saltbr-in 3.015 HRD-in -64.91, -46.49 66.87, 14.57 in-in-in SNCiii in-in ActLoopNT-in 2.865 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.57, 178.38 APE9-dihe-na 58.61, -169.26 APE8-dihe-in -123.99, 137.29 APE8-rot-in 306.99 APE67-dihe-in -67.45, -16.12 -20.54, -62.85 APE12-dist-in 12.788 APE11-dist-in 10.459 APE10-dist-in 6.269 APE9-dist-in 3.18 None None None XRAY 1.58 0.207 0.247 B 329 326 0 0 0 0 [[39, 324]] 1.0 6ypn Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.2e-69 240.7 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5CVHA P68400 2 328 391.0 ADP:401,IHP:402 ATPlike,Allosteric Active DFGin 7.351 16.265 BLAminus -108.96, -174.88 56.89, 75.34 -94.42, 15.0 293.73, 80.57 -64.71, -19.68 in-in in 9.418 Saltbr-in 2.869 HRD-in -72.87, -47.99 69.09, 10.68 in-in-in SNCiii in-in ActLoopNT-in 2.901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.61, 174.2 APE9-dihe-na 62.86, 175.04 APE8-dihe-in -103.43, 141.93 APE8-rot-in 298.78 APE67-dihe-in -64.49, -19.58 -33.62, -57.11 APE12-dist-in 12.739 APE11-dist-in 10.544 APE10-dist-in 6.1 APE9-dist-in 3.115 R21S None None XRAY 1.848 0.204 0.22 A 352 327 0 0 0 0 [[39, 324]] 1.0 5cvh Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5CVHB P68400 4 327 391.0 ADP:401,IHP:402 ATPlike,Allosteric Active DFGin 7.334 16.506 BLAminus -108.95, -175.21 55.5, 76.34 -94.47, 15.14 293.04, 80.42 -64.89, -20.52 in-in in 9.652 Saltbr-in 2.92 HRD-in -71.77, -46.42 66.39, 11.3 in-in-in SNCiii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.23, 173.23 APE9-dihe-na 63.78, 174.17 APE8-dihe-in -100.91, 142.72 APE8-rot-in 301.86 APE67-dihe-in -62.55, -20.09 -31.2, -58.6 APE12-dist-in 12.631 APE11-dist-in 10.426 APE10-dist-in 6.037 APE9-dist-in 3.119 R21S None None XRAY 1.848 0.204 0.22 B 352 324 0 0 0 0 [[39, 324]] 1.0 5cvh Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5MP8A P68400 3 327 391.0 ADP:404,RKN:406 ATPlike,Allosteric Active DFGin 7.33 16.163 BLAminus -110.84, -174.11 53.51, 76.37 -93.65, 17.26 296.86, 81.68 -66.57, -22.0 in-in in 9.317 Saltbr-in 2.863 HRD-in -67.91, -49.16 67.59, 13.12 in-in-in SNCiii in-in ActLoopNT-in 2.905 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.47, 167.73 APE9-dihe-na 65.86, 165.2 APE8-dihe-in -87.13, 142.99 APE8-rot-in 303.44 APE67-dihe-in -64.04, -21.15 -31.41, -58.51 APE12-dist-in 12.687 APE11-dist-in 10.464 APE10-dist-in 6.121 APE9-dist-in 3.162 R21S None None XRAY 1.92 0.213 0.224 A 352 325 0 0 0 0 [[39, 324]] 1.0 5mp8 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5MP8B P68400 3 325 391.0 ADP:402,RKN:405 ATPlike,Allosteric Active DFGin 7.324 16.349 BLAminus -110.28, -174.91 53.58, 76.31 -93.48, 18.26 296.68, 81.06 -66.02, -21.8 in-in in 9.448 Saltbr-in 2.907 HRD-in -64.03, -48.98 66.77, 13.43 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.49, 167.73 APE9-dihe-na 66.13, 163.08 APE8-dihe-in -85.62, 144.24 APE8-rot-in 302.43 APE67-dihe-in -63.28, -21.33 -32.96, -58.46 APE12-dist-in 12.646 APE11-dist-in 10.373 APE10-dist-in 6.113 APE9-dist-in 3.151 R21S None None XRAY 1.92 0.213 0.224 B 352 323 0 0 0 0 [[39, 324]] 1.0 5mp8 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5ORJB P68400 4 327 391.0 ADP:403,A4Q:404 ATPlike,Allosteric Active DFGin 7.265 16.341 BLAminus -111.15, -176.6 55.76, 79.82 -97.57, 16.74 293.2, 81.02 -66.75, -20.87 in-in in 9.479 Saltbr-in 3.015 HRD-in -67.24, -46.68 66.46, 8.84 in-in-in SNCiii in-in ActLoopNT-in 2.969 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.61, 174.53 APE9-dihe-na 65.24, 168.77 APE8-dihe-in -97.72, 138.95 APE8-rot-in 305.57 APE67-dihe-in -64.92, -22.35 -27.33, -57.79 APE12-dist-in 12.61 APE11-dist-in 10.406 APE10-dist-in 6.001 APE9-dist-in 3.126 R21S None None XRAY 1.99 0.201 0.221 B 352 324 0 0 0 0 [[39, 324]] 1.0 5orj Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5ORKA P68400 4 327 391.0 ADP:401,A4T:404 ATPlike,Allosteric Active DFGin 7.393 16.314 BLAminus -113.19, -173.71 54.76, 77.71 -95.81, 17.23 296.74, 84.21 -67.53, -20.95 in-in in 9.357 Saltbr-in 3.023 HRD-in -73.92, -50.16 69.3, 15.04 in-in-in SNCiii in-in ActLoopNT-in 2.873 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.23, 173.79 APE9-dihe-na 63.16, 167.87 APE8-dihe-in -90.44, 143.76 APE8-rot-in 298.85 APE67-dihe-in -64.65, -24.13 -31.17, -56.13 APE12-dist-in 12.631 APE11-dist-in 10.431 APE10-dist-in 6.062 APE9-dist-in 3.164 R21S None None XRAY 2.143 0.217 0.243 A 352 324 0 0 0 0 [[39, 324]] 1.0 5ork Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZYKA P68400 3 329 391.0 ADP:401,KEC:402 ATPlike,Allosteric Active DFGin 7.269 16.062 BLAminus -118.69, -179.59 61.79, 73.49 -91.41, 13.81 296.07, 81.24 -64.93, -20.57 in-in in 9.176 Saltbr-in 3.087 HRD-in -73.86, -46.68 67.1, 11.06 in-in-in SNCiii in-in ActLoopNT-in 2.84 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.3, 165.81 APE9-dihe-na 64.18, 165.94 APE8-dihe-in -85.42, 147.47 APE8-rot-in 296.52 APE67-dihe-in -73.89, -14.69 -37.67, -50.01 APE12-dist-in 12.741 APE11-dist-in 10.382 APE10-dist-in 6.284 APE9-dist-in 3.257 R21S,K74A,K75A,K76A None None XRAY 1.31 0.191 0.206 A 328 327 0 0 0 0 [[39, 324]] 1.0 7zyk Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5MPJA P68400 3 328 391.0 ADP:401,IHP:402,J2P:403 ATPlike,Allosteric,Allosteric Active DFGin 7.347 16.241 BLAminus -108.98, -172.35 51.93, 78.25 -97.48, 15.87 295.39, 81.91 -64.67, -20.13 in-in in 9.407 Saltbr-in 3.123 HRD-in -65.25, -50.84 66.66, 13.27 in-in-in SNCiii in-in ActLoopNT-in 2.941 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.52, 170.99 APE9-dihe-na 63.12, 171.83 APE8-dihe-in -95.06, 139.24 APE8-rot-in 294.97 APE67-dihe-in -59.9, -28.22 -27.45, -59.89 APE12-dist-in 12.787 APE11-dist-in 10.54 APE10-dist-in 6.103 APE9-dist-in 3.163 R21S None None XRAY 2.14 0.214 0.241 A 352 326 0 0 0 0 [[39, 324]] 1.0 5mpj Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OQUA P68400 4 327 391.0 ADP:401,A4B:402,IHP:408 ATPlike,Allosteric,Allosteric Active DFGin 7.448 16.25 BLAminus -109.0, -171.89 53.56, 75.1 -98.21, 18.1 294.2, 83.27 -72.09, -15.18 in-in in 9.369 Saltbr-in 2.827 HRD-in -72.33, -46.9 69.21, 10.87 in-in-in SNCiii in-in ActLoopNT-in 2.966 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.38, 169.57 APE9-dihe-na 63.73, 165.9 APE8-dihe-in -87.91, 142.9 APE8-rot-in 295.65 APE67-dihe-in -63.9, -27.03 -35.31, -52.27 APE12-dist-in 12.67 APE11-dist-in 10.466 APE10-dist-in 6.154 APE9-dist-in 3.14 R21S None None XRAY 2.324 0.221 0.244 A 352 324 0 0 0 0 [[39, 324]] 1.0 5oqu Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OSLA P68400 2 329 391.0 ADP:403,A9K:406,A9K:407 ATPlike,Allosteric,Allosteric Active DFGin 7.458 16.196 BLAminus -110.64, -174.68 55.81, 76.64 -96.18, 20.64 295.73, 82.92 -66.89, -23.66 in-in in 9.121 Saltbr-in 2.879 HRD-in -70.65, -51.51 73.54, 4.25 in-in-in SNCiii in-in ActLoopNT-in 2.987 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.81, 161.35 APE9-dihe-na 64.27, 160.37 APE8-dihe-in -77.24, 145.71 APE8-rot-in 308.44 APE67-dihe-in -67.76, -20.24 -38.72, -52.2 APE12-dist-in 12.834 APE11-dist-in 10.614 APE10-dist-in 6.334 APE9-dist-in 3.627 R21S,K74A,K75A,K76A None None XRAY 1.95 0.165 0.211 A 342 328 0 0 0 0 [[39, 324]] 1.0 5osl Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 9.4e-69 237.9 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5MOEB P68400 4 326 391.0 ADP:401,IHP:404,OQC:408,OQC:409 ATPlike,Allosteric,Allosteric,Allosteric Active DFGin 7.365 16.336 BLAminus -112.77, -173.88 54.48, 74.44 -91.99, 16.05 295.46, 80.22 -64.57, -20.81 in-in in 9.479 Saltbr-in 2.889 HRD-in -71.14, -46.59 66.38, 12.51 in-in-in SNCiii in-in ActLoopNT-in 2.873 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.91, 173.34 APE9-dihe-na 63.06, 172.04 APE8-dihe-in -102.52, 138.64 APE8-rot-in 304.11 APE67-dihe-in -65.23, -21.43 -26.29, -58.65 APE12-dist-in 12.604 APE11-dist-in 10.405 APE10-dist-in 6.063 APE9-dist-in 3.115 R21S None None XRAY 1.89 0.197 0.208 B 352 323 0 0 0 0 [[39, 324]] 1.0 5moe Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5ORJA P68400 3 327 391.0 ADP:404,A4Q:405,A4Q:406,IHP:407 ATPlike,Allosteric,Allosteric,Allosteric Active DFGin 7.315 16.182 BLAminus -113.3, -173.8 55.0, 78.92 -98.71, 18.23 293.93, 79.8 -66.17, -22.25 in-in in 9.33 Saltbr-in 3.023 HRD-in -76.84, -43.62 65.1, 10.62 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.05, 173.87 APE9-dihe-na 60.43, 175.34 APE8-dihe-in -100.91, 141.29 APE8-rot-in 294.98 APE67-dihe-in -64.65, -20.18 -32.63, -57.01 APE12-dist-in 12.69 APE11-dist-in 10.523 APE10-dist-in 6.135 APE9-dist-in 3.173 R21S None None XRAY 1.99 0.201 0.221 A 352 325 0 0 0 0 [[39, 324]] 1.0 5orj Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5MOEA P68400 3 327 391.0 ADP:401,IHP:404,OQC:409,OQC:410,OQC:411 ATPlike,Allosteric,Allosteric,Allosteric,Allosteric Active DFGin 7.374 16.184 BLAminus -113.03, -172.32 55.01, 74.02 -92.87, 17.49 295.96, 80.42 -65.27, -21.9 in-in in 9.335 Saltbr-in 2.823 HRD-in -73.11, -47.25 66.93, 11.97 in-in-in SNCiii in-in ActLoopNT-in 2.889 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.86, 173.34 APE9-dihe-na 63.53, 173.35 APE8-dihe-in -101.83, 138.62 APE8-rot-in 302.36 APE67-dihe-in -64.87, -18.25 -29.63, -58.0 APE12-dist-in 12.678 APE11-dist-in 10.501 APE10-dist-in 6.104 APE9-dist-in 3.111 R21S None None XRAY 1.89 0.197 0.208 A 352 325 0 0 0 0 [[39, 324]] 1.0 5moe Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZY0A P68400 3 329 391.0 KC0:401,ADP:402 Allosteric,ATPlike Active DFGin 7.445 16.236 BLAminus -121.24, -177.58 61.58, 73.29 -95.57, 19.56 295.71, 82.78 -68.2, -19.93 in-in in 9.143 Saltbr-in 2.835 HRD-in -73.32, -51.17 71.86, 9.65 in-in-in SNCiii in-in ActLoopNT-in 2.895 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.67, 170.29 APE9-dihe-na 67.14, 162.49 APE8-dihe-in -85.98, 150.23 APE8-rot-in 297.56 APE67-dihe-in -70.24, -15.73 -44.75, -49.95 APE12-dist-in 12.618 APE11-dist-in 10.267 APE10-dist-in 6.142 APE9-dist-in 3.16 R21S,K74A,K75A,K76A None None XRAY 1.44 0.2 0.214 A 328 327 0 0 0 0 [[39, 324]] 1.0 7zy0 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 8AE7A P68400 3 329 391.0 LVU:403,ADP:404 Allosteric,ATPlike Active DFGin 7.27 16.12 BLAminus -116.86, -174.55 56.89, 71.78 -90.66, 15.89 296.23, 82.47 -66.69, -21.09 in-in in 9.166 Saltbr-in 2.902 HRD-in -74.15, -48.16 69.73, 11.22 in-in-in SNCiii in-in ActLoopNT-in 2.844 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.63, 168.68 APE9-dihe-na 61.6, 159.52 APE8-dihe-in -83.61, 146.39 APE8-rot-in 290.46 APE67-dihe-in -69.61, -14.41 -36.06, -54.13 APE12-dist-in 12.669 APE11-dist-in 10.213 APE10-dist-in 6.181 APE9-dist-in 3.228 R21S,K74A,K75A,K76A None None XRAY 1.28 0.205 0.232 A 328 327 0 0 0 0 [[39, 324]] 1.0 8ae7 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7I8IA P68400 3 329 391.0 A1BZ5:402,ADP:403 Type1,Allosteric Active DFGin 7.509 16.198 BLAminus -114.79, -179.23 51.74, 77.25 -89.04, 19.22 296.06, 83.25 -67.78, -21.4 in-in in 9.214 Saltbr-in 2.747 HRD-in -73.97, -49.71 72.98, 8.01 in-in-in SNCiii in-in ActLoopNT-in 2.871 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.34, 166.93 APE9-dihe-na 64.1, 155.12 APE8-dihe-in -82.08, 146.04 APE8-rot-in 277.65 APE67-dihe-in -69.99, -12.65 -33.63, -55.35 APE12-dist-in 12.849 APE11-dist-in 10.502 APE10-dist-in 6.346 APE9-dist-in 3.29 R21S,K74A,K75A,K76A None None XRAY 1.47 0.182 0.208 A 328 327 0 0 0 0 [[39, 324]] 1.0 7i8i Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7I8LA P68400 3 329 391.0 A1B0I:401,ADP:402 Type1,Allosteric Active DFGin 7.469 16.174 BLAminus -114.83, -178.51 53.33, 76.08 -89.6, 18.77 294.58, 80.79 -67.15, -22.69 in-in in 9.223 Saltbr-in 2.765 HRD-in -77.98, -46.47 70.26, 9.7 in-in-in SNCiii in-in ActLoopNT-in 2.884 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.24, 169.88 APE9-dihe-na 62.42, 155.06 APE8-dihe-in -81.97, 147.51 APE8-rot-in 279.2 APE67-dihe-in -72.11, -11.91 -35.53, -53.62 APE12-dist-in 12.861 APE11-dist-in 10.518 APE10-dist-in 6.393 APE9-dist-in 3.294 R21S,K74A,K75A,K76A None None XRAY 1.48 0.184 0.203 A 328 327 0 0 0 0 [[39, 324]] 1.0 7i8l Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7I8QA P68400 3 329 391.0 A1BZU:402,ADP:403 Type1,Allosteric Active DFGin 7.479 16.147 BLAminus -114.23, -175.31 54.63, 75.78 -91.18, 24.13 295.07, 81.04 -69.52, -25.94 in-in in 8.973 Saltbr-in 2.76 HRD-in -73.41, -51.65 72.74, 4.84 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.8, 171.34 APE9-dihe-na 61.22, 163.5 APE8-dihe-in -95.71, 145.02 APE8-rot-in 296.25 APE67-dihe-in -71.38, -16.61 -34.03, -51.24 APE12-dist-in 12.809 APE11-dist-in 10.441 APE10-dist-in 6.256 APE9-dist-in 3.114 R21S,K74A,K75A,K76A None None XRAY 1.66 0.191 0.22 A 328 327 0 0 0 0 [[39, 324]] 1.0 7i8q Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC GSK3B GSK3B_HUMAN 4NM5A P49841 24 383 420.0 ADP:60401 ATPlike Active DFGin 6.55 14.006 BLAminus -136.16, -177.73 61.88, 88.47 -108.64, 28.76 287.87, 80.78 -73.66, -15.44 in-in in 8.619 Saltbr-in 2.673 HRD-in -65.83, -43.73 64.82, 15.23 in-in-in SNCiii in-in ActLoopNT-in 2.839 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.92, 173.97 APE9-dihe-na 66.26, 147.02 APE8-dihe-in -77.1, 152.8 APE8-rot-in 293.28 APE67-dihe-inflip 82.03, -25.76 -52.23, 150.7 APE12-dist-in 13.279 APE11-dist-in 11.599 APE10-dist-in 6.949 APE9-dist-in 3.238 None None None XRAY 2.3 0.185 0.232 A 377 360 0 0 0 0 [[56, 340]] 1.0 4nm5 Homo sapiens CMGC_GSK3B_HUMAN CMGC 2.3e-70 243.3 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 4NM7A P49841 25 383 420.0 ADP:60401 ATPlike Active DFGin 6.515 13.993 BLAminus -137.35, -178.06 62.82, 88.6 -107.3, 24.56 288.41, 80.2 -69.84, -12.63 in-in in 8.818 Saltbr-in 2.743 HRD-in -66.5, -46.64 67.84, 11.79 in-in-in SNCiii in-in ActLoopNT-in 2.829 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.92, 172.54 APE9-dihe-na 68.99, 153.43 APE8-dihe-in -86.9, 151.79 APE8-rot-in 300.04 APE67-dihe-inflip 84.67, -25.93 -50.38, 146.2 APE12-dist-in 13.355 APE11-dist-in 11.678 APE10-dist-in 6.905 APE9-dist-in 3.21 None None None XRAY 2.3 0.185 0.234 A 377 354 2 0 0 0 [[56, 340]] 1.0 4nm7 Homo sapiens CMGC_GSK3B_HUMAN CMGC 2.3e-70 243.3 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 4NM0A P49841 26 383 420.0 ADP:60408 ATPlike Inactive DFGin 6.641 14.213 BLAminus -133.4, -174.33 56.9, 85.51 -105.72, 27.83 287.31, 80.39 -76.48, -2.57 in-in in 8.774 Saltbr-in 3.094 HRD-in -69.87, -45.12 67.03, 14.87 in-in-out SNCiio in-out ActLoopNT-in 2.927 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -71.29, 168.54 APE9-dihe-na 70.19, 144.11 APE8-dihe-in -96.47, 160.21 APE8-rot-out 64.82 APE67-dihe-inflip 78.46, -27.02 -43.67, 149.07 APE12-dist-in 13.091 APE11-dist-in 10.885 APE10-dist-in 6.571 APE9-dist-in 3.135 None None None XRAY 2.5 0.193 0.239 A 389 355 0 0 0 0 [[56, 340]] 1.0 4nm0 Homo sapiens CMGC_GSK3B_HUMAN CMGC 2.5e-70 243.2 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 4NM3A P49841 6 383 420.0 ADP:60409 ATPlike Active DFGin 6.475 13.947 BLAminus -129.98, -178.05 63.17, 87.87 -103.96, 21.26 289.38, 80.04 -65.46, -16.35 in-in in 8.806 Saltbr-in 2.726 HRD-in -69.81, -46.77 71.59, 6.75 in-in-in SNCiii in-in ActLoopNT-in 2.75 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.34, 169.99 APE9-dihe-na 69.15, 146.37 APE8-dihe-in -83.47, 151.55 APE8-rot-in 296.54 APE67-dihe-inflip 86.0, -31.11 -49.79, 146.79 APE12-dist-in 13.269 APE11-dist-in 11.484 APE10-dist-in 6.907 APE9-dist-in 3.112 None SEP9 SEP9 XRAY 2.1 0.197 0.242 A 389 357 2 0 0 0 [[56, 340]] 1.0 4nm3 Homo sapiens CMGC_GSK3B_HUMAN CMGC 2.5e-70 243.2 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 1J1CA P49841 35 388 420.0 ADP:60430 ATPlike Active DFGin 6.812 13.93 BLAminus -139.24, -179.75 62.79, 82.17 -97.34, 25.19 286.68, 82.3 -65.83, -19.9 in-in in 8.601 Saltbr-in 2.647 HRD-in -68.65, -43.85 68.34, 7.36 in-in-in SNCiii in-in ActLoopNT-in 2.977 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -90.05, 172.96 APE9-dihe-na 78.17, 130.85 APE8-dihe-in -73.54, 145.97 APE8-rot-in 310.16 APE67-dihe-inflip 99.09, -35.01 -54.43, 141.28 APE12-dist-in 13.077 APE11-dist-in 11.067 APE10-dist-in 5.926 APE9-dist-in 3.2 None None None XRAY 2.1 0.218 0.242 A 420 354 0 0 0 0 [[56, 340]] 1.0 1j1c Homo sapiens CMGC_GSK3B_HUMAN CMGC 3.2e-70 242.8 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 1J1CB P49841 23 386 420.0 ADP:60930 ATPlike Active DFGin 6.694 13.709 BLAminus -138.27, -179.99 63.33, 82.68 -100.46, 28.2 289.88, 80.26 -70.45, -13.94 in-in in 8.52 Saltbr-in 2.738 HRD-in -67.92, -43.36 67.59, 5.86 in-in-in SNCiii in-in ActLoopNT-in 2.98 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -91.71, 170.27 APE9-dihe-na 78.71, 139.86 APE8-dihe-in -81.56, 140.05 APE8-rot-in 302.5 APE67-dihe-inflip 101.62, -36.53 -50.52, 137.44 APE12-dist-in 12.868 APE11-dist-in 11.128 APE10-dist-in 6.025 APE9-dist-in 3.208 None None None XRAY 2.1 0.218 0.242 B 420 364 0 0 0 0 [[56, 340]] 1.0 1j1c Homo sapiens CMGC_GSK3B_HUMAN CMGC 3.2e-70 242.8 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC MAPK1 MK01_HUMAN 4IZ5A P28482 11 357 360.0 ADP:900 ATPlike Inactive DFGin 6.574 16.226 BLAminus -133.03, 170.47 61.68, 96.87 -113.24, 29.97 280.98, 72.88 -75.05, -15.97 in-out in 8.943 Saltbr-out 6.337 HRD-in -70.37, -54.19 76.22, -6.05 out-in-out SNCoio in-out ActLoopNT-in 2.804 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -135.59, 107.64 APE9-dihe-na -86.59, -36.52 APE8-dihe-in -63.86, 130.93 APE8-rot-in 305.07 APE67-dihe-in -64.33, -26.99 -124.19, 30.24 APE12-dist-in 10.012 APE11-dist-out 7.082 APE10-dist-out 8.249 APE9-dist-out 10.51 T185E None None XRAY 3.19 0.245 0.292 A 356 347 0 0 0 0 [[25, 313]] 1.0 4iz5 Homo sapiens CMGC_MAPK1_HUMAN CMGC 2.5e-85 292.3 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4IZ5B P28482 11 357 360.0 ADP:900 ATPlike Inactive DFGin 6.614 16.236 BLAminus -130.77, 169.05 63.18, 96.88 -112.33, 27.86 280.9, 72.0 -73.48, -17.21 in-out in 8.952 Saltbr-out 6.284 HRD-in -71.55, -52.24 74.21, -4.59 out-in-out SNCoio in-out ActLoopNT-in 2.846 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -135.05, 108.67 APE9-dihe-na -88.18, -35.19 APE8-dihe-in -65.83, 129.75 APE8-rot-in 303.93 APE67-dihe-in -64.9, -24.28 -122.7, 29.42 APE12-dist-in 10.031 APE11-dist-out 7.085 APE10-dist-out 8.25 APE9-dist-out 10.503 T185E None None XRAY 3.19 0.245 0.292 B 356 347 0 0 0 0 [[25, 313]] 1.0 4iz5 Homo sapiens CMGC_MAPK1_HUMAN CMGC 2.5e-85 292.3 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4IZ5C P28482 11 357 360.0 ADP:900 ATPlike Inactive DFGin 6.604 16.232 BLAminus -131.01, 170.44 62.04, 96.83 -112.78, 28.94 280.74, 73.4 -74.17, -17.63 in-out in 8.945 Saltbr-out 6.36 HRD-in -72.88, -51.67 75.48, -6.0 out-in-out SNCoio in-out ActLoopNT-in 2.868 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -133.99, 108.02 APE9-dihe-na -87.46, -36.5 APE8-dihe-in -65.77, 130.32 APE8-rot-in 303.26 APE67-dihe-in -66.37, -24.82 -122.99, 29.53 APE12-dist-in 10.014 APE11-dist-out 7.068 APE10-dist-out 8.22 APE9-dist-out 10.497 T185E None None XRAY 3.19 0.245 0.292 C 356 347 0 0 0 0 [[25, 313]] 1.0 4iz5 Homo sapiens CMGC_MAPK1_HUMAN CMGC 2.5e-85 292.3 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4IZ5D P28482 11 357 360.0 ADP:900 ATPlike Inactive DFGin 6.601 16.232 BLAminus -131.94, 170.02 62.64, 97.08 -112.75, 27.73 280.79, 72.08 -72.23, -17.73 in-out in 8.96 Saltbr-out 6.321 HRD-in -71.89, -53.7 75.24, -4.58 out-in-out SNCoio in-out ActLoopNT-in 2.846 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -135.09, 108.16 APE9-dihe-na -88.37, -35.4 APE8-dihe-in -66.59, 130.93 APE8-rot-in 303.88 APE67-dihe-in -65.41, -25.44 -123.75, 30.53 APE12-dist-in 10.012 APE11-dist-out 7.088 APE10-dist-out 8.224 APE9-dist-out 10.46 T185E None None XRAY 3.19 0.245 0.292 D 356 347 0 0 0 0 [[25, 313]] 1.0 4iz5 Homo sapiens CMGC_MAPK1_HUMAN CMGC 2.5e-85 292.3 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC PRP4K PRP4K_HUMAN 4IFCA Q13523 668 1005 1007.0 ADP:1101 ATPlike Inactive DFGin 6.321 14.363 BLAminus -121.88, -179.85 58.81, 82.85 -100.37, 25.78 288.2, 87.48 -70.57, -26.82 in-in in 8.257 Saltbr-in 2.844 HRD-in -62.43, -44.6 59.26, 25.1 in-in-out SNCiio in-out ActLoopNT-in 2.816 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -73.15, 134.81 APE9-dihe-na 75.99, 141.41 APE8-dihe-in -55.8, 125.16 APE8-rot-in 286.42 APE67-dihe-in -66.36, -24.99 -29.31, -53.31 APE12-dist-out 15.538 APE11-dist-in 11.831 APE10-dist-out 8.871 APE9-dist-in 3.287 None PTR849 PTR849 XRAY 2.13 0.243 0.256 A 358 328 10 0 0 0 [[687, 1003]] 1.0 4ifc Homo sapiens CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
CMGC PRP4K PRP4K_HUMAN 4IFCB Q13523 670 1005 1007.0 ADP:1101 ATPlike Inactive DFGin 6.419 14.343 BLAminus -121.41, 176.18 59.35, 85.75 -102.3, 24.13 289.47, 86.91 -69.6, -26.74 in-in in 8.319 Saltbr-in 2.779 HRD-in -64.36, -42.37 58.06, 25.43 in-in-out SNCiio in-out ActLoopNT-in 2.901 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -73.87, 139.78 APE9-dihe-na 75.02, 140.04 APE8-dihe-in -56.36, 124.13 APE8-rot-in 293.29 APE67-dihe-in -65.74, -25.94 -27.6, -52.65 APE12-dist-out 15.537 APE11-dist-in 11.809 APE10-dist-out 8.576 APE9-dist-in 3.251 None PTR849 PTR849 XRAY 2.13 0.243 0.256 B 358 330 6 0 0 0 [[687, 1003]] 1.0 4ifc Homo sapiens CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1 301 301 833 834 835 837 839 717 732 736 812 814 813 815 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
CMGC SRPK1 SRPK1_HUMAN 1WBPA Q96SB4 67 655 655.0 ADP:60950 ATPlike Active DFGin 6.093 14.484 BLAminus -120.66, 177.09 55.57, 73.12 -93.78, 28.92 297.48, 63.42 -60.8, -41.52 in-in in 9.616 Saltbr-in 3.534 HRD-in -64.25, -33.37 61.64, -4.85 in-in-in SNCiii in-in ActLoopNT-in 2.855 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.23, 175.25 APE9-dihe-na 64.87, 133.49 APE8-dihe-in -68.33, 140.58 APE8-rot-in 294.72 APE67-dihe-in -48.4, -19.96 -25.96, -79.02 APE12-dist-in 12.421 APE11-dist-in 10.401 APE10-dist-in 7.455 APE9-dist-in 2.973 None None None XRAY 2.4 0.228 0.247 A 397 350 22 0 0 0 [[80, 653]] 1.0 1wbp Homo sapiens CMGC_SRPK1_HUMAN CMGC 2e-139 469.9 1 301 301 496 497 498 500 502 109 124 128 210 212 211 213 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
NEK NEK2 NEK2_HUMAN 2W5AA P51955 3 271 445.0 ADP:61280 ATPlike Inactive None 12.645 15.915 None -79.34, 164.62 -62.62, 148.1 -64.74, -38.56 187.15, 76.57 112.78, 109.44 out-out out 13.134 Saltbr-out 14.422 HRD-out -72.83, 129.73 -137.0, 151.51 out-out-out SNCooo out-out ActLoopNT-out 11.638 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -50.6, -46.29 APE9-dihe-na -59.22, 149.78 APE8-dihe-in -97.74, 124.68 APE8-rot-in 301.95 APE67-dihe-out -55.08, -31.55 -81.03, 66.49 APE12-dist-out 14.668 APE11-dist-out 19.148 APE10-dist-out 20.029 APE9-dist-out 14.901 None None None XRAY 1.55 0.173 0.19 A 279 259 10 0 0 3 [[8, 271]] 1.0 2w5a Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK NEK7 NEK7_HUMAN 9NFQC Q8TDX7 20 300 302.0 ADP:1301 ATPlike Inactive DFGin 7.307 11.98 None -150.16, -164.53 74.32, -54.68 63.51, 118.45 304.42, 170.07 -50.32, 115.41 out-out out 14.52 Saltbr-out 10.448 HRD-in -75.46, -45.69 71.31, -4.13 out-out-out SNCooo out-out ActLoopNT-out 9.177 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -73.74, 126.83 APE9-dihe-na 80.61, 29.64 APE8-dihe-in -127.17, 154.0 APE8-rot-out 66.52 APE67-dihe-out -56.05, -43.39 -68.04, 167.92 APE12-dist-out 15.571 APE11-dist-out 14.531 APE10-dist-out 11.825 APE9-dist-out 8.487 None None None XRAY 3.25 0.214 0.261 C 304 281 0 0 0 0 [[34, 294]] 1.0 9nfq Homo sapiens NEK_NEK7_HUMAN NEK 4.3e-110 373.2 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 2WQNA Q8TDX7 21 300 302.0 ADP:1301 ATPlike Inactive DFGin 7.366 14.509 None -71.0, 173.16 -64.84, 135.91 -62.15, 999.0 305.22, 52.49 999.0, 999.0 out-out out 14.034 Saltbr-out 12.947 HRD-in -74.75, -50.15 86.13, -19.52 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 77.46 APE8-rot-none 999.0 APE67-dihe-out -63.25, -48.51 -54.4, 143.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.192 0.221 A 310 259 21 0 0 18 [[34, 294]] 1.0 2wqn Homo sapiens NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1 255 255 178 179 180 182 184 63 82 86 158 160 159 161 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
OTHER BUB1 BUB1_HUMAN 4QPMA O43683 740 1083 1085.0 ADP:61501 ATPlike Inactive DFGin 4.981 12.01 BLAminus -120.67, -179.49 71.42, 87.57 -106.61, 23.42 308.95, 170.82 -66.89, -34.13 in-in in 7.796 Saltbr-in 2.914 HRD-in -66.14, -48.04 82.18, -4.6 in-in-out SNCiio in-out ActLoopNT-in 2.763 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -64.85, 156.56 APE9-dihe-na -64.63, -39.16 APE8-dihe-in -93.29, 139.46 APE8-rot-in 316.87 APE67-dihe-in -78.63, -37.4 -63.71, -30.48 APE12-dist-in 11.725 APE11-dist-out 14.148 APE10-dist-out 10.635 APE9-dist-out 10.792 None SEP969 SEP969 XRAY 2.202 0.231 0.269 A 356 329 15 0 0 0 [[787, 1056]] 1.0 4qpm Homo sapiens OTHER_BUB1_HUMAN BUB 3.8e-136 458.4 1 265 265 945 946 947 949 951 821 830 834 914 916 915 917 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN 4QPMB O43683 740 1081 1085.0 ADP:61501 ATPlike Inactive DFGin 5.101 12.046 BLAminus -119.58, -176.38 67.12, 86.64 -105.74, 27.36 310.01, 169.79 -71.02, -28.54 in-in in 7.772 Saltbr-in 2.901 HRD-in -61.72, -45.96 85.02, -11.94 in-in-out SNCiio in-out ActLoopNT-in 2.744 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -63.28, 153.27 APE9-dihe-na -53.34, -51.78 APE8-dihe-in -91.15, 141.66 APE8-rot-in 311.67 APE67-dihe-in -72.26, -39.02 -59.96, -32.38 APE12-dist-in 11.697 APE11-dist-out 14.062 APE10-dist-out 10.116 APE9-dist-out 11.022 None SEP969 SEP969 XRAY 2.202 0.231 0.269 B 356 328 14 0 0 0 [[787, 1056]] 1.0 4qpm Homo sapiens OTHER_BUB1_HUMAN BUB 3.8e-136 458.4 1 265 265 945 946 947 949 951 821 830 834 914 916 915 917 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN 4R8QA O43683 736 1083 1085.0 ADP:1501 ATPlike Inactive DFGin 5.122 11.829 BLAminus -125.96, -174.79 66.73, 90.85 -108.81, 15.71 306.38, 172.71 -63.09, -30.66 in-in in 7.711 Saltbr-in 2.874 HRD-in -64.09, -49.64 83.12, -3.69 in-in-out SNCiio in-out ActLoopNT-in 2.763 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iooo APE10-dihe-na -164.58, 163.81 APE9-dihe-na -85.55, 176.61 APE8-dihe-out -73.85, 5.37 APE8-rot-in 315.03 APE67-dihe-out 103.71, -26.99 -140.38, 18.96 APE12-dist-in 11.744 APE11-dist-out 16.324 APE10-dist-out 13.204 APE9-dist-out 6.446 None None None XRAY 2.31 0.226 0.264 A 365 332 16 0 0 0 [[787, 1056]] 1.0 4r8q Homo sapiens OTHER_BUB1_HUMAN BUB 4.2e-136 458.3 1 265 265 945 946 947 949 951 821 830 834 914 916 915 917 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN 5DMZA O43683 735 1083 1085.0 ADP:1101 ATPlike Inactive DFGin 5.221 12.068 BLAminus -133.45, -169.91 60.82, 85.13 -106.54, 14.57 302.2, 157.68 -62.7, -37.35 in-out in 7.701 Saltbr-out 3.764 HRD-in -69.13, -48.67 85.78, -11.89 out-in-out SNCoio in-out ActLoopNT-in 2.865 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iooi APE10-dihe-na -165.83, 155.63 APE9-dihe-na -80.56, 157.26 APE8-dihe-out -52.44, -38.51 APE8-rot-in 307.01 APE67-dihe-out 105.78, 2.77 -74.96, -12.99 APE12-dist-in 11.785 APE11-dist-out 16.036 APE10-dist-out 12.54 APE9-dist-in 5.943 None SEP969 SEP969 XRAY 2.4 0.212 0.245 A 365 340 9 0 0 0 [[787, 1056]] 1.0 5dmz Homo sapiens OTHER_BUB1_HUMAN BUB 4.2e-136 458.3 1 265 265 945 946 947 949 951 821 830 834 914 916 915 917 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN 5DMZB O43683 735 1083 1085.0 ADP:1101 ATPlike Inactive DFGin 5.22 11.852 BLAminus -128.64, -170.27 62.18, 89.46 -111.04, 16.28 301.8, 159.34 -67.29, -36.18 in-out in 7.572 Saltbr-out 4.025 HRD-in -67.97, -51.5 86.46, -15.21 out-in-out SNCoio in-out ActLoopNT-in 2.845 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iooi APE10-dihe-na -164.62, 154.63 APE9-dihe-na -71.85, 159.91 APE8-dihe-out -55.62, -36.95 APE8-rot-in 307.18 APE67-dihe-out 117.19, -7.42 -77.21, -19.75 APE12-dist-in 11.575 APE11-dist-out 15.552 APE10-dist-out 12.266 APE9-dist-in 5.742 None SEP969 SEP969 XRAY 2.4 0.212 0.245 B 365 340 9 0 0 0 [[787, 1056]] 1.0 5dmz Homo sapiens OTHER_BUB1_HUMAN BUB 4.2e-136 458.3 1 265 265 945 946 947 949 951 821 830 834 914 916 915 917 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER CDC7 CDC7_HUMAN 4F99A O00311 41 572 574.0 ADP:601 ATPlike None DFGin 5.87 13.865 BLAminus -125.0, 176.56 71.88, 86.33 -103.78, 20.73 291.54, 82.68 -65.96, -16.39 in-in in 8.793 Saltbr-in 3.139 HRD-in -63.98, -49.82 74.42, -3.19 in-in-none SNCiin in-none ActLoopNT-in 2.732 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -77.05, 117.3 APE8-rot-in 305.41 APE67-dihe-in -66.81, -0.89 -45.84, -42.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.33 0.194 0.241 A 361 312 42 0 0 20 [[58, 569]] 1.0 4f99 Homo sapiens OTHER_CDC7_HUMAN CMGC 2e-18 137.7 1 161 295 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 4F9AA O00311 39 572 574.0 ADP:601 ATPlike None DFGin 5.759 13.936 BLAminus -128.61, 175.54 70.41, 87.99 -103.92, 20.97 294.06, 81.72 -65.32, -14.75 in-in in 8.757 Saltbr-in 3.408 HRD-in -57.32, -50.7 72.28, 5.36 in-in-none SNCiin in-none ActLoopNT-in 2.928 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -93.93, 115.55 APE8-rot-in 301.45 APE67-dihe-in -62.39, -13.04 -45.16, -41.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.17 0.208 0.25 A 361 315 41 0 0 20 [[58, 569]] 1.0 4f9a Homo sapiens OTHER_CDC7_HUMAN CMGC 2e-18 137.7 1 161 295 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 4F9AC O00311 37 572 574.0 ADP:601 ATPlike None DFGin 5.913 14.207 BLAminus -118.89, -178.58 68.69, 81.33 -98.73, 26.53 287.38, 89.39 -66.37, -28.9 in-in in 8.846 Saltbr-in 2.634 HRD-in -64.95, -54.17 83.11, 0.13 in-in-none SNCiin in-none ActLoopNT-in 2.643 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -84.47, 120.44 APE8-rot-in 299.37 APE67-dihe-in -57.71, -12.62 -43.45, -49.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.17 0.208 0.25 C 361 317 41 0 0 20 [[58, 569]] 1.0 4f9a Homo sapiens OTHER_CDC7_HUMAN CMGC 2e-18 137.7 1 161 295 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 6YA7A O00311 39 573 574.0 ADP:60604 ATPlike None DFGin 5.888 14.044 BLAminus -126.02, 169.07 75.11, 84.03 -93.96, 22.86 290.05, 97.62 -71.31, -16.58 in-in in 8.937 Saltbr-in 2.775 HRD-in -69.05, -41.87 77.4, -14.54 in-in-none SNCiin in-none ActLoopNT-in 2.812 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 153.99, -157.91 APE8-dihe-in -128.95, 137.92 APE8-rot-in 297.63 APE67-dihe-inflip 100.28, -12.86 -58.0, 134.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.714 None None None XRAY 1.67 0.158 0.185 A 358 345 5 0 0 5 [[58, 569]] 1.0 6ya7 Homo sapiens OTHER_CDC7_HUMAN CMGC 2e-18 137.3 1 161 296 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 375 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 6YA8A O00311 38 572 574.0 ADP:60601,BEF:60603 ATPlike,Allosteric None DFGin 6.168 14.087 BLAminus -118.93, 173.08 76.34, 83.66 -102.33, 21.87 291.62, 81.2 -67.07, -22.7 in-in in 8.709 Saltbr-in 2.738 HRD-in -65.76, -44.2 72.35, -4.4 in-in-none SNCiin in-none ActLoopNT-in 2.755 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na -83.06, -154.71 APE8-dihe-in -48.63, 132.1 APE8-rot-in 306.86 APE67-dihe-in -66.07, -7.37 -59.08, -35.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.888 None None None XRAY 1.79 0.167 0.197 A 359 338 13 0 0 13 [[58, 569]] 1.0 6ya8 Homo sapiens OTHER_CDC7_HUMAN CMGC 2e-18 137.3 1 161 296 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 375 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 6D3KA P19525 256 544 551.0 ADP:601 ATPlike Inactive DFGin 6.192 14.114 BLAminus -129.83, -165.99 54.1, 79.73 -96.08, 34.77 294.46, 85.4 -58.44, -36.42 in-in in 8.721 Saltbr-in 3.027 HRD-in -84.66, -50.66 80.44, -19.76 in-in-out SNCiio in-out ActLoopNT-in 2.976 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 139.0 APE8-rot-out 55.24 APE67-dihe-out -85.5, -25.12 -112.78, 51.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.212 0.266 A 323 258 31 0 0 10 [[175, 537]] 1.0 6d3k Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 3.5e-49 173.8 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 6D3KB P19525 255 541 551.0 ADP:601 ATPlike Inactive DFGin 6.393 14.221 BLAminus -124.42, -164.03 49.77, 78.4 -95.78, 27.52 286.59, 80.74 -46.98, -40.31 in-in in 8.57 Saltbr-in 2.966 HRD-in -83.22, -38.98 75.5, -28.78 in-in-out SNCiio in-out ActLoopNT-in 3.149 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -18.31 APE8-rot-in 303.08 APE67-dihe-out -107.33, 146.38 64.92, 69.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.212 0.266 B 323 254 33 0 0 11 [[175, 537]] 1.0 6d3k Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 3.5e-49 173.8 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 6D3KC P19525 257 541 551.0 ADP:601 ATPlike Inactive DFGin 6.312 14.466 BLAminus -121.59, -161.34 59.64, 70.11 -92.29, 27.04 287.49, 78.94 -65.31, -34.89 in-in in 8.513 Saltbr-in 2.676 HRD-in -58.89, -48.8 72.65, -1.02 in-in-out SNCiio in-out ActLoopNT-in 2.885 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 168.95 APE8-dihe-in -45.87, 135.3 APE8-rot-out 180.18 APE67-dihe-in -61.65, -21.89 -90.59, -3.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.194 None None None XRAY 2.6 0.212 0.266 C 323 258 27 0 0 3 [[175, 537]] 1.0 6d3k Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 3.5e-49 173.8 1 256 256 431 432 433 435 437 296 308 312 411 413 412 414 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER ERN1 ERN1_HUMAN 4YZDA O75460 563 964 977.0 ADP:1002 ATPlike Inactive DFGin 7.106 13.454 BLBplus -141.52, 169.79 75.76, 4.13 -62.0, 156.83 53.76, 79.18 72.65, 35.33 out-out out 15.885 Saltbr-out 13.41 HRD-in -64.16, -47.27 74.91, -18.55 out-out-out SNCooo out-out ActLoopNT-out 10.584 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -69.65, 158.55 APE9-dihe-na 98.62, 175.79 APE8-dihe-in -108.17, 135.68 APE8-rot-in 302.59 APE67-dihe-inflip 100.94, -24.59 -56.48, 129.95 APE12-dist-none 999.0 APE11-dist-in 13.406 APE10-dist-out 8.161 APE9-dist-in 3.423 None None None XRAY 3.102 0.234 0.273 A 405 383 18 0 0 12 [[571, 832]] 1.0 4yzd Homo sapiens OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZDB O75460 563 963 977.0 ADP:1002 ATPlike Inactive DFGin 7.204 13.179 BLBplus -141.12, 169.65 69.57, 15.58 -67.08, 155.42 48.06, 78.07 72.22, 36.23 out-out out 15.88 Saltbr-out 13.118 HRD-in -63.57, -45.81 74.7, -19.84 out-out-none SNCoon out-none ActLoopNT-out 10.581 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -69.77, 158.99 APE9-dihe-na 99.89, 174.78 APE8-dihe-in -110.07, 134.42 APE8-rot-in 300.85 APE67-dihe-inflip 103.95, -24.75 -57.78, 133.16 APE12-dist-none 999.0 APE11-dist-in 12.672 APE10-dist-in 7.568 APE9-dist-in 3.528 None None None XRAY 3.102 0.234 0.273 B 405 385 15 0 0 12 [[571, 832]] 1.0 4yzd Homo sapiens OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZDC O75460 563 964 977.0 ADP:1001 ATPlike Inactive DFGin 7.292 13.556 BLBplus -142.06, 170.34 76.33, 5.28 -64.41, 157.35 50.79, 79.33 73.41, 36.41 out-out out 16.194 Saltbr-out 13.253 HRD-in -63.95, -47.78 74.02, -20.41 out-out-none SNCoon out-none ActLoopNT-out 10.581 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -70.78, 158.57 APE9-dihe-na 97.6, 174.43 APE8-dihe-in -111.17, 134.53 APE8-rot-in 303.43 APE67-dihe-inflip 103.93, -24.42 -56.8, 132.74 APE12-dist-none 999.0 APE11-dist-in 12.41 APE10-dist-in 7.784 APE9-dist-in 3.412 None None None XRAY 3.102 0.234 0.273 C 405 379 21 0 0 12 [[571, 832]] 1.0 4yzd Homo sapiens OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 3P23A O75460 563 963 977.0 ADP:1002 ATPlike Inactive DFGin 7.34 13.709 BLBplus -135.51, 176.11 64.76, 22.4 -82.8, 150.63 49.7, 79.84 86.4, 10.86 out-out out 16.088 Saltbr-out 13.069 HRD-in -67.24, -58.17 81.51, -4.45 out-out-out SNCooo out-out ActLoopNT-out 10.402 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -84.29, 161.18 APE9-dihe-na 82.17, -162.33 APE8-dihe-in -132.44, 136.42 APE8-rot-in 302.1 APE67-dihe-inflip 108.83, 5.18 -54.01, 119.49 APE12-dist-none 999.0 APE11-dist-in 12.558 APE10-dist-out 9.123 APE9-dist-in 3.196 None None None XRAY 2.7 0.238 0.294 A 432 386 15 0 0 12 [[571, 832]] 1.0 3p23 Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 3P23B O75460 564 964 977.0 ADP:1002 ATPlike Inactive DFGin 7.483 13.646 BLBplus -139.9, 176.5 76.83, 14.87 -83.89, 150.35 55.49, 87.42 97.57, -33.78 out-out out 15.936 Saltbr-out 12.658 HRD-in -62.38, -39.7 42.05, 35.85 out-out-out SNCooo out-out ActLoopNT-out 9.701 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 143.86 APE9-dihe-na -111.46, -135.27 APE8-dihe-in -106.96, 135.19 APE8-rot-in 295.43 APE67-dihe-inflip 111.53, -14.08 -51.84, 125.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.213 APE9-dist-in 3.477 None None None XRAY 2.7 0.238 0.294 B 432 386 15 0 0 12 [[571, 832]] 1.0 3p23 Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 3P23C O75460 561 964 977.0 ADP:1002 ATPlike Inactive DFGin 7.544 13.173 BLBplus -149.53, -176.42 65.18, 18.98 -70.01, 144.07 39.63, 91.88 97.04, -114.33 out-out out 15.805 Saltbr-out 13.146 HRD-in -52.59, -55.72 76.18, 1.65 out-out-out SNCooo out-out ActLoopNT-out 11.142 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iioi APE10-dihe-na -53.61, -99.6 APE9-dihe-na -77.2, 171.08 APE8-dihe-in -47.05, 145.36 APE8-rot-in 345.28 APE67-dihe-out 116.59, -10.88 85.51, 60.96 APE12-dist-in 12.838 APE11-dist-in 13.243 APE10-dist-out 9.353 APE9-dist-in 3.507 None None None XRAY 2.7 0.238 0.294 C 432 390 14 0 0 11 [[571, 832]] 1.0 3p23 Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 3P23D O75460 561 963 977.0 ADP:1002 ATPlike Inactive DFGin 7.409 13.263 BLBplus -138.88, 177.03 72.28, 10.83 -71.52, 154.68 50.97, 93.75 83.32, -17.5 out-out out 16.034 Saltbr-out 13.018 HRD-in -58.06, -54.76 77.4, -2.34 out-out-out SNCooo out-out ActLoopNT-out 10.057 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnoi APE10-dihe-na 999.0, 162.88 APE9-dihe-na -149.96, -140.99 APE8-dihe-in -73.3, 139.85 APE8-rot-in 325.01 APE67-dihe-out 115.82, -9.19 91.28, 60.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.113 APE9-dist-in 4.038 None None None XRAY 2.7 0.238 0.294 D 432 387 16 0 0 14 [[571, 832]] 1.0 3p23 Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER PIK3R4 PI3R4_HUMAN 8SORA Q99570 15 1358 1358.0 ADP:1401 ATPlike Pseudo DFGin 9.418 15.81 BLBminus -148.68, -163.36 56.86, 40.25 -54.73, 139.1 286.63, 79.79 -95.49, 38.09 out-out out 17.808 Saltbr-out 21.09 HRD-in -78.26, -64.21 93.22, -18.74 out-out-out SNCooo out-out ActLoopNT-out 9.121 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na 53.41, 44.04 APE9-dihe-na -115.24, -10.88 APE8-dihe-out 68.3, 15.78 APE8-rot-na 299.15 APE67-dihe-out -125.94, 101.57 -74.9, 135.12 APE12-dist-out 14.302 APE11-dist-out 17.974 APE10-dist-out 21.055 APE9-dist-out 15.977 None None None EM 3.96 999.0 999.0 A 1358 1156 28 0 0 0 [[19, 321]] 1.0 8sor Homo sapiens OTHER_PIK3R4_HUMAN PIK3R4 5.8e-151 507.9 1 298 298 165 166 167 169 171 53 73 77 145 147 146 148 240 200 195 194 193 192 191 190 189 104 Phosphoinositide 3-kinase regulatory subunit 4
OTHER RNASEL RN5A_HUMAN 4OAUC Q05823 25 719 741.0 ADP:801 ATPlike Pseudo DFGin 6.529 12.379 BLAminus -152.72, -178.03 59.98, 103.61 -125.32, 12.02 305.12, 98.0 -75.28, 8.76 in-in in 6.993 Saltbr-in 2.623 HRD-in -74.91, -47.94 67.23, 8.17 in-in-na SNCiia in-na ActLoopNT-in 2.913 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -67.73, 111.98 APE9-dihe-na -66.2, -20.72 APE8-dihe-na -68.67, -28.85 APE8-rot-na 187.68 APE67-dihe-na -72.58, -38.81 -76.25, -36.54 APE12-dist-na 14.068 APE11-dist-na 16.875 APE10-dist-na 14.985 APE9-dist-na 14.333 H672N None None XRAY 2.6 0.213 0.251 C 699 692 0 0 0 0 [[353, 594]] 1.0 4oau Homo sapiens OTHER_RNASEL_HUMAN RNASEL 4.1e-136 459.9 1 242 242 502 503 504 506 508 392 404 408 482 484 483 485 520 522 517 516 515 514 513 512 511 435 2-5A-dependent ribonuclease
STE MAP2K1 MP2K1_HUMAN 3EQIA Q02750 39 382 393.0 ADP:2 ATPlike Inactive DFGin 6.097 14.146 BLBplus -145.58, 171.19 59.48, 41.15 -92.75, 128.75 41.67, 88.89 -58.7, 127.06 out-out out 15.214 Saltbr-out 14.728 HRD-in -57.14, -59.8 81.96, -12.14 out-out-out SNCooo out-out ActLoopNT-out 10.702 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -160.04, 114.16 APE9-dihe-na -79.94, 159.35 APE8-dihe-in -52.77, 143.91 APE8-rot-out 201.8 APE67-dihe-in -60.21, -14.42 -106.05, 1.41 APE12-dist-out 20.148 APE11-dist-out 15.239 APE10-dist-out 17.296 APE9-dist-out 9.228 S298N,S299K,Y300F None None XRAY 1.9 0.165 999.0 A 360 315 29 0 0 0 [[68, 361]] 1.0 3eqi Homo sapiens STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3MBLA Q02750 62 381 393.0 ADP:60535,LSG:60007 ATPlike,Type3 Inactive DFGin 6.344 13.403 BLBplus -137.82, 175.17 58.41, 36.59 -88.68, 159.6 41.78, 90.19 -90.36, 101.21 out-out out 15.592 Saltbr-out 16.004 HRD-in -72.77, -61.87 90.83, -9.53 out-out-out SNCooo out-out ActLoopNT-out 9.779 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -62.62, 116.57 APE9-dihe-na -76.67, -13.86 APE8-dihe-out -100.19, -102.3 APE8-rot-out 48.6 APE67-dihe-out -109.33, 135.36 -59.01, 126.17 APE12-dist-out 18.705 APE11-dist-out 17.881 APE10-dist-out 19.945 APE9-dist-out 14.473 None None None XRAY 2.6 0.169 0.215 A 328 289 31 0 0 0 [[68, 361]] 1.0 3mbl Homo sapiens STE_MAP2K1_HUMAN STE 1.3e-97 332.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4ARKA Q02750 62 382 393.0 ADP:61383,M3K:61385 ATPlike,Type3 Inactive DFGin 6.213 13.32 BLBplus -143.7, -171.53 62.76, 23.96 -76.11, 159.51 42.79, 94.02 -85.45, 75.28 out-out out 15.353 Saltbr-out 15.901 HRD-in -67.47, -65.14 92.89, -4.81 out-out-out SNCooo out-out ActLoopNT-out 9.329 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -100.98, -15.83 APE9-dihe-na -32.88, 128.59 APE8-dihe-out -40.11, 20.06 APE8-rot-out 186.45 APE67-dihe-out -132.58, 138.09 -155.02, 124.88 APE12-dist-out 16.349 APE11-dist-out 18.139 APE10-dist-out 23.554 APE9-dist-out 14.426 None None None XRAY 2.6 0.174 0.211 A 341 290 31 0 0 0 [[68, 361]] 1.0 4ark Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3EQGA Q02750 39 381 393.0 ADP:2,4BM:1 ATPlike,Type3 Inactive DFGin 6.606 13.743 BLBplus -138.18, 179.2 59.31, 28.5 -81.55, 153.56 35.8, 92.23 -71.67, 64.14 out-out out 15.474 Saltbr-out 14.566 HRD-in -60.95, -65.33 94.63, -12.32 out-out-out SNCooo out-out ActLoopNT-out 9.231 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -104.38, 152.44 APE9-dihe-na -137.47, 114.08 APE8-dihe-in -13.21, 123.19 APE8-rot-out 216.51 APE67-dihe-in -71.17, -7.71 -101.04, 15.41 APE12-dist-out 19.79 APE11-dist-out 16.56 APE10-dist-out 18.855 APE9-dist-out 9.489 S298N,S299K,Y300F None None XRAY 2.5 0.21 0.273 A 360 314 29 0 0 0 [[68, 361]] 1.0 3eqg Homo sapiens STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 6NYBB Q02750 56 383 393.0 ADP:60601,LCJ:60901 ATPlike,Type3 Inactive DFGin 5.959 14.037 BLBplus -152.28, 170.52 57.47, 42.76 -92.93, 161.49 47.46, 85.53 -88.41, 68.49 out-out out 15.47 Saltbr-out 17.602 HRD-in -56.15, -54.04 65.39, 11.35 out-out-out SNCooo out-out ActLoopNT-out 8.292 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -140.81, 127.27 APE9-dihe-na -93.66, 157.79 APE8-dihe-out -110.82, -26.16 APE8-rot-out 55.56 APE67-dihe-out -130.29, 148.43 -119.13, 133.87 APE12-dist-out 17.78 APE11-dist-out 18.319 APE10-dist-out 22.379 APE9-dist-out 12.159 S218A,S222A None None EM 4.1 999.0 999.0 B 415 289 39 0 0 0 [[68, 361]] 1.0 6nyb Homo sapiens STE_MAP2K1_HUMAN STE 1.3e-96 329.0 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3EQHA Q02750 39 381 393.0 5BM:1,ADP:2 Type3,ATPlike Inactive DFGin 6.846 13.348 BLBplus -141.56, 168.5 59.76, 36.07 -79.95, 154.58 28.74, 98.71 -78.77, 88.92 out-out out 15.25 Saltbr-out 13.926 HRD-in -70.86, -51.49 82.66, -16.34 out-out-out SNCooo out-out ActLoopNT-out 9.845 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na 72.18, 69.91 APE9-dihe-na -156.93, 105.03 APE8-dihe-in -35.31, 137.66 APE8-rot-out 209.36 APE67-dihe-in -58.22, -17.3 -105.41, 1.3 APE12-dist-out 17.889 APE11-dist-out 18.024 APE10-dist-out 19.276 APE9-dist-out 9.655 S298N,S299K,Y300F None None XRAY 2.0 0.192 999.0 A 360 314 29 0 0 0 [[68, 361]] 1.0 3eqh Homo sapiens STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE PAK3 PAK3_HUMAN 6FD3A O75914 261 556 559.0 ADP:60603 ATPlike Active DFGin 5.952 14.149 BLAminus -133.62, -174.01 64.9, 77.07 -96.85, 18.52 289.09, 83.73 -72.71, -11.5 in-in in 8.938 Saltbr-in 2.761 HRD-in -71.32, -50.63 74.19, 1.63 in-in-in SNCiii in-in ActLoopNT-in 2.913 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.75, 147.44 APE9-dihe-na 132.72, -161.48 APE8-dihe-in -114.41, 121.22 APE8-rot-in 305.33 APE67-dihe-in -64.48, -19.99 -44.4, -48.2 APE12-dist-in 8.849 APE11-dist-in 11.358 APE10-dist-in 5.576 APE9-dist-in 3.34 A537D None T8L436 XRAY 1.52 0.176 0.19 A 300 296 0 0 0 0 [[283, 534]] 1.0 6fd3 Homo sapiens STE_PAK3_HUMAN STE 1.1e-94 322.5 1 257 257 419 420 421 423 425 312 328 332 399 401 400 402 459 447 442 441 440 439 438 437 436 358 Serine/threonine-protein kinase PAK 3
STE STK24 STK24_HUMAN 3A7JA Q9Y6E0 25 311 443.0 ADP:60500 ATPlike Active DFGin 6.747 14.583 BLAminus -138.67, 168.25 71.5, 79.52 -101.19, 20.06 287.01, 95.64 -64.31, -27.68 in-in in 8.53 Saltbr-in 2.552 HRD-in -69.86, -43.49 67.32, -1.05 in-in-in SNCiii in-in ActLoopNT-in 2.741 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.28, 158.62 APE9-dihe-na 130.53, -164.99 APE8-dihe-in -116.23, 120.86 APE8-rot-in 304.02 APE67-dihe-in -60.63, -23.79 -34.15, -55.13 APE12-dist-in 8.296 APE11-dist-in 11.11 APE10-dist-in 5.251 APE9-dist-in 3.288 None TPO190 TPO190 XRAY 1.5 0.191 0.21 A 303 287 0 0 0 0 [[36, 286]] 1.0 3a7j Homo sapiens STE_STK24_HUMAN STE 3.6e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4O27B Q9Y6E0 30 309 443.0 ADP:60500 ATPlike Inactive DFGin 4.867 13.82 None -148.38, -173.28 56.25, -124.14 31.74, 82.19 64.76, 101.5 98.89, -78.6 in-in in 8.937 Saltbr-in 2.901 HRD-in -80.55, -48.63 69.48, -10.03 in-in-out SNCiio in-out ActLoopNT-in 3.017 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -123.0, 177.15 APE9-dihe-na 103.58, 170.34 APE8-dihe-in -99.19, 143.02 APE8-rot-out 34.53 APE67-dihe-in -72.39, -25.42 -54.44, -42.62 APE12-dist-in 9.028 APE11-dist-in 10.879 APE10-dist-in 5.562 APE9-dist-in 3.644 T190E None None XRAY 3.185 0.203 0.26 B 281 280 0 0 0 0 [[36, 286]] 1.0 4o27 Homo sapiens STE_STK24_HUMAN STE 5.5e-100 339.9 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STRADA STRAA_HUMAN 8VSUB Q7RTN6 60 401 431.0 ADP:2001 ATPlike Pseudo DFGin 5.328 13.743 None -141.72, 9.36 -84.56, 30.72 -65.1, -14.12 305.81, 3.72 -62.58, -31.2 out-none out 10.229 Saltbr-none 999.0 HRD-out -66.66, 151.23 -136.62, 153.73 none-in-out SNCnio in-out ActLoopNT-in 2.866 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_iooo APE10-dihe-na -55.51, -37.77 APE9-dihe-na -75.16, -6.37 APE8-dihe-out -108.58, -14.7 APE8-rot-na 180.94 APE67-dihe-in -58.61, -34.89 -50.23, -38.37 APE12-dist-in 8.342 APE11-dist-out 7.821 APE10-dist-out 13.057 APE9-dist-out 11.052 None None None EM 2.86 999.0 999.0 B 429 306 36 0 0 0 [[69, 379]] 1.0 8vsu Homo sapiens STE_STRADA_HUMAN STE 6.5e-87 297.3 1 257 257 212 213 214 216 218 100 118 122 192 194 193 195 261 247 242 241 240 239 238 237 236 148 STE20-related kinase adapter protein alpha
STE TAOK3 TAOK3_HUMAN 6BDNA Q9H2K8 8 314 898.0 ADP:404 ATPlike Active DFGin 6.771 13.825 BLAminus -136.73, -179.28 62.01, 80.15 -97.31, 23.85 293.38, 102.08 -68.85, -11.35 in-in in 8.485 Saltbr-in 2.682 HRD-in -74.02, -52.69 74.7, -5.2 in-in-in SNCiii in-in ActLoopNT-in 2.797 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.94, 158.28 APE9-dihe-na 130.64, -172.75 APE8-dihe-in -113.55, 120.19 APE8-rot-in 301.22 APE67-dihe-in -62.99, -26.26 -46.03, -46.8 APE12-dist-in 8.28 APE11-dist-in 11.04 APE10-dist-in 5.18 APE9-dist-in 3.383 R2A,K3A None None XRAY 1.5 0.187 0.214 A 320 307 0 0 0 0 [[24, 277]] 1.0 6bdn Homo sapiens STE_TAOK3_HUMAN STE 6.3e-90 307.0 4 257 254 164 165 166 168 170 53 72 76 144 146 145 147 203 188 183 182 181 180 179 178 177 102 Serine/threonine-protein kinase TAO3
TKL BMPR2 BMPR2_HUMAN 3G2FA Q13873 197 510 1038.0 ADP:900 ATPlike Active DFGin 6.957 13.944 BLAminus -131.62, -179.2 66.08, 79.87 -102.79, 27.43 304.26, 96.52 -59.99, -25.3 in-in in 8.107 Saltbr-in 2.757 HRD-in -69.81, -50.66 82.19, -10.63 in-in-in SNCiii in-in ActLoopNT-in 2.981 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.1, -22.11 APE9-dihe-na -73.96, -168.61 APE8-dihe-in -80.16, 127.03 APE8-rot-in 308.56 APE67-dihe-in -65.91, -22.58 -59.75, -41.5 APE12-dist-in 11.403 APE11-dist-in 12.63 APE10-dist-in 7.026 APE9-dist-in 4.033 None None CAS288,CAS397,CAS496 XRAY 2.35 0.21 0.246 A 336 305 9 0 0 9 [[202, 503]] 1.0 3g2f Homo sapiens TKL_BMPR2_HUMAN TKL 1.4e-75 260.2 2 266 265 350 351 352 354 356 230 243 247 330 332 331 333 405 386 381 380 379 378 377 376 375 280 Bone morphogenetic protein receptor type-2
TKL BMPR2 BMPR2_HUMAN 3G2FB Q13873 198 513 1038.0 ADP:900 ATPlike Active DFGin 6.968 14.008 BLAminus -149.7, 179.95 61.07, 87.18 -102.54, 11.93 293.8, 112.47 -56.7, -17.91 in-in in 8.065 Saltbr-in 2.732 HRD-in -73.22, -52.25 87.7, -10.0 in-in-in SNCiii in-in ActLoopNT-in 2.914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.94, -26.41 APE9-dihe-na -71.73, -175.39 APE8-dihe-in -71.07, 133.08 APE8-rot-in 315.55 APE67-dihe-in -68.07, -13.93 -56.75, -42.89 APE12-dist-in 11.194 APE11-dist-in 12.108 APE10-dist-in 6.494 APE9-dist-in 3.722 None None CAS288,CAS397,CAS496 XRAY 2.35 0.21 0.246 B 336 303 13 0 0 13 [[202, 503]] 1.0 3g2f Homo sapiens TKL_BMPR2_HUMAN TKL 1.4e-75 260.2 2 266 265 350 351 352 354 356 230 243 247 330 332 331 333 405 386 381 380 379 378 377 376 375 280 Bone morphogenetic protein receptor type-2
TKL BMPR2 BMPR2_HUMAN 6UNPB Q13873 197 509 1038.0 ADP:601 ATPlike Active DFGin 6.917 14.051 BLAminus -140.56, 176.5 63.35, 76.41 -96.26, 25.8 302.12, 104.12 -61.08, -20.73 in-in in 7.904 Saltbr-in 2.865 HRD-in -75.95, -48.17 78.17, -6.91 in-in-in SNCiii in-in ActLoopNT-in 2.977 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.29, -9.38 APE9-dihe-na -69.43, -161.26 APE8-dihe-in -89.59, 127.34 APE8-rot-in 301.19 APE67-dihe-in -48.39, -33.11 -62.11, -43.63 APE12-dist-in 12.009 APE11-dist-in 12.508 APE10-dist-in 7.099 APE9-dist-in 4.016 D485G None CAS288,CAS397,CAS496 XRAY 2.3 0.19 0.211 B 363 303 10 0 0 8 [[202, 503]] 1.0 6unp Homo sapiens TKL_BMPR2_HUMAN TKL 1.1e-74 257.3 2 266 265 350 351 352 354 356 230 243 247 330 332 331 333 405 386 381 380 379 378 377 376 375 280 Bone morphogenetic protein receptor type-2
TKL BMPR2 BMPR2_HUMAN 6UNPA Q13873 199 509 1038.0 ADP:601,ADP:602 ATPlike,Allosteric None DFGin 7.015 14.066 BLAminus -140.5, 177.86 62.51, 75.21 -94.82, 26.77 301.08, 104.11 -62.66, -20.97 in-in in 7.983 Saltbr-in 2.832 HRD-in -73.31, -49.03 80.8, -8.07 in-in-none SNCiin in-none ActLoopNT-in 2.92 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -134.35, -10.44 APE9-dihe-na -70.57, -158.87 APE8-dihe-in -91.29, 127.64 APE8-rot-in 299.54 APE67-dihe-in -49.77, -33.71 -61.84, -45.11 APE12-dist-none 999.0 APE11-dist-in 12.741 APE10-dist-in 7.284 APE9-dist-in 4.093 D485G None CAS288,CAS397,CAS496 XRAY 2.3 0.19 0.211 A 363 302 9 0 0 9 [[202, 503]] 1.0 6unp Homo sapiens TKL_BMPR2_HUMAN TKL 1.1e-74 257.3 2 266 265 350 351 352 354 356 230 243 247 330 332 331 333 405 386 381 380 379 378 377 376 375 280 Bone morphogenetic protein receptor type-2
TKL KSR2 KSR2_HUMAN 7JUQB Q6VAB6 652 932 950.0 ADP:1001 ATPlike Pseudo DFGin 5.723 13.43 BLBplus -139.35, 152.22 61.66, 33.54 -71.04, 141.2 52.07, 82.92 82.4, -21.94 out-none out 15.389 Saltbr-none 999.0 HRD-in -71.47, -51.16 73.41, 1.02 none-out-out SNCnoo out-out ActLoopNT-out 7.459 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -57.45, -45.23 APE9-dihe-na -90.48, -7.37 APE8-dihe-out -66.85, -54.6 APE8-rot-na 183.3 APE67-dihe-in -71.76, -8.04 -52.06, -44.72 APE12-dist-out 18.487 APE11-dist-out 15.103 APE10-dist-out 19.519 APE9-dist-out 11.963 None None None XRAY 3.22 0.256 0.288 B 342 277 4 0 0 3 [[665, 930]] 1.0 7juq Homo sapiens TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TYR ABL1 ABL1_HUMAN 2G2IA P00519 229 502 1130.0 ADP:820 ATPlike Inactive DFGin 6.631 13.433 BLAminus -148.4, 173.75 80.3, 76.24 -98.47, 37.85 308.34, 118.79 -64.97, -55.29 in-in in 8.005 Saltbr-in 3.247 HRD-out -103.94, 83.88 -55.25, 17.72 in-in-in SNCiii in-in ActLoopNT-in 3.064 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -140.34, 116.79 APE9-dihe-in -127.46, 160.87 APE8-dihe-in -56.61, 91.87 APE8-rot-na 28.18 APE67-dihe-in -56.4, -10.87 -40.77, -65.33 APE12-dist-na 14.904 APE11-dist-na 10.573 APE10-dist-na 12.836 APE9-dist-in 7.31 H396P None None XRAY 3.12 0.251 0.308 A 287 271 3 0 0 0 [[242, 495]] 1.0 2g2i Homo sapiens TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2G2IB P00519 232 500 1130.0 ADP:821 ATPlike Inactive DFGin 6.623 13.745 BLAminus -144.73, -170.13 58.63, 49.5 -73.16, 23.66 306.98, 113.05 -58.19, -50.38 in-in in 7.795 Saltbr-in 2.872 HRD-out -111.21, 97.67 -66.16, -14.66 in-in-in SNCiii in-in ActLoopNT-in 3.404 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.86, 132.09 APE9-dihe-in -111.79, 159.65 APE8-dihe-in -83.23, 82.29 APE8-rot-na 32.48 APE67-dihe-in -53.07, -28.27 -29.82, -59.17 APE12-dist-na 14.975 APE11-dist-na 10.34 APE10-dist-na 12.829 APE9-dist-in 7.625 H396P None None XRAY 3.12 0.251 0.308 B 287 265 4 0 0 0 [[242, 495]] 1.0 2g2i Homo sapiens TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ALK ALK_HUMAN 3LCTA Q9UM73 1093 1400 1620.0 ADP:1412 ATPlike Inactive DFGin 6.266 15.193 ABAminus -127.22, 10.26 -136.37, 129.73 -130.23, 18.7 291.41, 88.16 -49.74, -46.74 in-none in 8.1 Saltbr-none 999.0 HRD-in -78.72, -45.58 81.21, -3.39 none-out-out SNCnoo out-out ActLoopNT-out 6.886 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -94.62, -10.42 APE9-dihe-in -67.88, 140.77 APE8-dihe-in -81.63, 62.42 APE8-rot-na 34.08 APE67-dihe-in -66.16, -16.53 -61.79, -27.56 APE12-dist-na 14.739 APE11-dist-na 15.112 APE10-dist-na 9.981 APE9-dist-out 8.031 S1281G None None XRAY 2.1 0.207 0.255 A 344 308 0 0 0 0 [[1116, 1385]] 1.0 3lct Homo sapiens TYR_ALK_HUMAN TYR 5e-90 307.3 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR EGFR EGFR_HUMAN 4RIWB P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.947 14.509 None -144.94, -140.84 60.54, -94.56 67.75, 16.38 293.55, 125.63 -72.75, -24.64 in-in in 8.962 Saltbr-in 2.577 HRD-out -81.5, 87.13 -71.92, 10.44 in-in-none SNCiin in-none ActLoopNT-in 2.914 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.11 APE8-dihe-in -64.72, 105.47 APE8-rot-na 338.81 APE67-dihe-in -78.09, 0.73 -66.98, -35.92 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.339 V948R,F997A,L1001A None None XRAY 3.1 0.233 0.287 B 345 293 4 0 0 4 [[712, 970]] 1.0 4riw Homo sapiens TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIWD P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 6.016 14.399 None -147.43, -141.55 60.24, -94.38 68.1, 17.38 294.17, 126.48 -72.23, -23.22 in-in in 8.845 Saltbr-in 3.081 HRD-in -78.23, -46.1 60.09, 5.38 in-in-in SNCiii in-in ActLoopNT-in 2.84 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.64, 111.47 APE9-dihe-in -129.74, 134.09 APE8-dihe-in -62.84, 106.17 APE8-rot-na 337.89 APE67-dihe-in -78.37, 3.33 -65.15, -34.97 APE12-dist-na 11.397 APE11-dist-na 9.946 APE10-dist-na 9.723 APE9-dist-in 6.015 V948R,F997A,L1001A None None XRAY 3.1 0.233 0.287 D 345 297 0 0 0 0 [[712, 970]] 1.0 4riw Homo sapiens TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIXB P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.919 14.579 None -139.87, -153.46 71.8, -106.42 74.55, 12.91 300.13, 117.16 -73.01, -18.89 in-in in 8.778 Saltbr-in 2.851 HRD-out -79.93, 91.22 -73.37, 9.67 in-in-none SNCiin in-none ActLoopNT-in 2.815 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.04 APE8-dihe-in -57.54, 105.82 APE8-rot-na 336.15 APE67-dihe-in -83.65, 5.55 -71.82, -34.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.644 V948R,F997A,L1001A None None XRAY 3.1 0.21 0.258 B 345 293 4 0 0 4 [[712, 970]] 1.0 4rix Homo sapiens TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIXD P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.984 14.396 None -138.76, -155.76 70.86, -102.17 73.98, 14.44 299.1, 114.44 -71.0, -18.03 in-in in 8.433 Saltbr-in 2.13 HRD-in -75.74, -46.31 59.89, 5.04 in-in-in SNCiii in-in ActLoopNT-in 2.879 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.43, 115.77 APE9-dihe-in -128.43, 136.25 APE8-dihe-in -57.6, 106.59 APE8-rot-na 335.5 APE67-dihe-in -81.04, 4.3 -70.58, -32.32 APE12-dist-na 11.336 APE11-dist-na 10.144 APE10-dist-na 10.428 APE9-dist-in 5.987 V948R,F997A,L1001A None None XRAY 3.1 0.21 0.258 D 345 297 0 0 0 0 [[712, 970]] 1.0 4rix Homo sapiens TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIYB P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.952 14.655 None -154.99, 131.23 -173.19, -76.87 64.96, 12.46 300.69, 132.23 -71.94, -28.32 in-in in 8.685 Saltbr-in 2.95 HRD-out -79.99, 96.69 -77.78, 9.7 in-in-none SNCiin in-none ActLoopNT-in 2.884 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.59 APE8-dihe-in -76.15, 93.2 APE8-rot-na 346.43 APE67-dihe-in -79.33, 6.83 -64.49, -46.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.35 V948R,F997A,L1001A None None XRAY 2.981 0.221 0.267 B 345 293 4 0 0 4 [[712, 970]] 1.0 4riy Homo sapiens TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIYD P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.892 14.398 None -146.72, -160.68 90.34, -82.61 63.94, 14.36 297.22, 112.71 -69.53, -27.12 in-in in 8.333 Saltbr-in 2.327 HRD-in -73.91, -45.57 61.02, 4.8 in-in-in SNCiii in-in ActLoopNT-in 2.976 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.34, 113.28 APE9-dihe-in -130.38, 137.58 APE8-dihe-in -69.37, 99.85 APE8-rot-na 344.82 APE67-dihe-in -75.56, 6.57 -58.1, -42.52 APE12-dist-na 11.232 APE11-dist-na 10.201 APE10-dist-na 9.961 APE9-dist-in 6.258 V948R,F997A,L1001A None None XRAY 2.981 0.221 0.267 D 345 297 0 0 0 0 [[712, 970]] 1.0 4riy Homo sapiens TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EPHB1 EPHB1_HUMAN 7KPMA P54762 611 888 984.0 ADP:901 ATPlike Inactive DFGin 6.148 15.077 None -129.01, -161.15 68.81, 56.56 -103.91, 999.0 293.32, 103.77 999.0, 999.0 in-in in 7.744 Saltbr-in 2.709 HRD-in -77.02, -45.59 75.58, -13.35 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 76.94 APE8-rot-na 30.04 APE67-dihe-in -77.93, -6.39 -53.89, -41.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None PTR647 PTR647 XRAY 1.608 0.169 0.197 A 279 255 23 0 0 23 [[619, 880]] 1.0 7kpm Homo sapiens TYR_EPHB1_HUMAN TYR 2.3e-109 370.6 2 261 260 761 762 763 765 767 651 668 672 741 743 742 744 806 794 789 788 787 786 785 784 783 698 Ephrin type-B receptor 1
TYR ITK ITK_HUMAN 4M15A Q08881 355 617 620.0 QWS:701,ADP:702 Type3,ATPlike Inactive DFGin 7.939 15.29 BLBplus -140.12, 163.53 73.68, 16.28 -64.43, 134.2 34.87, 95.02 79.06, -6.9 out-out out 17.066 Saltbr-out 16.254 HRD-in -70.42, -53.15 83.67, -22.02 out-out-out SNCooo out-out ActLoopNT-out 7.74 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -106.59, 12.56 APE9-dihe-in -62.84, 135.73 APE8-dihe-in -75.4, 60.83 APE8-rot-na 30.68 APE67-dihe-in -61.26, -23.89 -55.9, -32.96 APE12-dist-na 16.836 APE11-dist-na 19.515 APE10-dist-na 14.784 APE9-dist-out 9.152 None None None XRAY 1.52 0.172 0.186 A 269 263 0 0 0 0 [[363, 614]] 1.0 4m15 Homo sapiens TYR_ITK_HUMAN TYR 1.2e-92 315.8 1 260 260 499 500 501 503 505 391 406 410 479 481 480 482 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR JAK1-2 JAK1_HUMAN 5KHWA P23458 867 1153 1154.0 ADP:1201 ATPlike Inactive DFGin 6.293 13.595 ABAminus -113.62, -36.19 -113.51, 112.49 -104.48, 28.51 302.05, 98.46 -68.45, -35.55 in-in in 8.017 Saltbr-in 2.811 HRD-in -53.69, -54.55 74.32, 4.71 in-in-in SNCiii in-in ActLoopNT-in 2.817 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.25, 151.86 APE9-dihe-in -139.19, 145.92 APE8-dihe-in -78.07, 75.73 APE8-rot-na 29.65 APE67-dihe-in -77.72, -3.4 -55.44, -31.5 APE12-dist-na 13.014 APE11-dist-na 7.332 APE10-dist-na 9.905 APE9-dist-in 6.022 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.47 0.188 0.231 A 316 278 9 0 0 0 [[583, 847], [875, 1151]] 2.0 5khw Homo sapiens TYR_JAK1-2_HUMAN TYR 2.6e-87 298.4 2 259 258 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
TYR JAK1-2 JAK1_HUMAN 6C7YA P23458 869 1153 1154.0 ADP:61201 ATPlike Active DFGin 6.032 13.967 BLAminus -134.15, -164.18 58.49, 84.96 -109.28, 28.04 298.78, 97.45 -66.39, -27.05 in-in in 8.311 Saltbr-in 2.732 HRD-in -67.59, -46.53 68.25, 12.43 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.91, 151.36 APE9-dihe-in -137.76, 143.32 APE8-dihe-in -74.71, 81.76 APE8-rot-na 30.49 APE67-dihe-in -79.4, -2.38 -65.2, -24.66 APE12-dist-na 12.972 APE11-dist-na 8.02 APE10-dist-na 10.344 APE9-dist-in 6.316 None PTR1035 PTR1035 XRAY 2.499 0.21 0.241 A 286 273 12 0 0 0 [[583, 847], [875, 1151]] 2.0 6c7y Homo sapiens TYR_JAK1-2_HUMAN TYR 1.8e-87 298.9 2 259 258 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
TYR JAK1-2 JAK1_HUMAN 5KHWB P23458 867 1153 1154.0 ADP:1201 ATPlike Inactive DFGin 6.188 13.787 BLAminus -126.62, -174.05 50.66, 92.23 -105.71, 28.99 301.42, 97.18 -62.73, -33.32 in-in in 7.991 Saltbr-in 2.817 HRD-in -54.38, -55.02 75.74, 4.0 in-in-out SNCiio in-out ActLoopNT-in 2.811 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -83.14, 18.97 APE9-dihe-in -58.32, 113.18 APE8-dihe-in -82.04, 77.86 APE8-rot-na 28.29 APE67-dihe-in -76.85, -3.42 -56.14, -32.61 APE12-dist-na 7.879 APE11-dist-na 9.695 APE10-dist-na 6.605 APE9-dist-in 5.912 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.47 0.188 0.231 B 316 278 9 0 0 0 [[583, 847], [875, 1151]] 2.0 5khw Homo sapiens TYR_JAK1-2_HUMAN TYR 2.6e-87 298.4 2 259 258 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
TYR KIT KIT_HUMAN 1PKGA P10721 567 927 976.0 ADP:1480 ATPlike Inactive DFGin 6.481 14.136 BLAminus -130.56, -161.98 47.26, 79.76 -98.59, 34.29 290.92, 88.36 -71.71, -28.0 in-out in 8.138 Saltbr-out 3.883 HRD-in -70.61, -44.29 71.47, -6.33 out-in-out SNCoio in-out ActLoopNT-in 2.981 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 81.05, 87.98 APE9-dihe-in -123.34, 167.37 APE8-dihe-in -84.87, 64.98 APE8-rot-na 27.08 APE67-dihe-in -64.22, -13.25 -46.84, -45.75 APE12-dist-na 14.817 APE11-dist-na 9.099 APE10-dist-na 11.173 APE9-dist-in 6.894 None PTR568,PTR570 PTR568,PTR570 XRAY 2.9 0.229 0.311 A 329 292 11 0 0 0 [[589, 926]] 1.0 1pkg Homo sapiens TYR_KIT_HUMAN TYR 4.5e-102 346.9 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 1PKGB P10721 566 929 976.0 ADP:1486 ATPlike None DFGin 6.537 13.819 BLAminus -133.94, -165.75 57.9, 93.59 -119.64, 36.22 290.23, 87.19 -80.39, -20.36 in-in in 6.934 Saltbr-in 2.915 HRD-in -72.14, -51.55 69.69, 17.19 in-in-none SNCiin in-none ActLoopNT-in 2.888 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 110.55 APE9-dihe-in -141.29, 162.93 APE8-dihe-in -80.26, 78.25 APE8-rot-na 29.66 APE67-dihe-in -62.74, -24.13 -40.98, -43.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.765 APE9-dist-in 6.494 None PTR568,PTR570 PTR568,PTR570 XRAY 2.9 0.229 0.311 B 329 279 27 0 0 13 [[589, 926]] 1.0 1pkg Homo sapiens TYR_KIT_HUMAN TYR 4.5e-102 346.9 1 260 260 809 810 811 813 815 623 640 644 789 791 790 792 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR MERTK MERTK_HUMAN 3BRBA Q12866 575 861 999.0 ADP:901 ATPlike Inactive DFGin 6.074 13.609 BLBplus -149.4, 172.79 64.51, 33.37 -100.26, 164.7 46.71, 83.96 59.32, 174.03 out-out out 13.75 Saltbr-out 12.558 HRD-in -82.25, -54.47 71.68, 7.51 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -42.31 APE8-dihe-in -85.78, 61.15 APE8-rot-na 26.09 APE67-dihe-in -74.59, -1.92 -45.39, -40.65 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.341 None None None XRAY 1.9 0.195 0.24 A 313 260 27 0 0 16 [[587, 856]] 1.0 3brb Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 3BRBB Q12866 575 863 999.0 ADP:901 ATPlike Inactive DFGin 5.874 13.373 BLBplus -148.45, 175.8 65.39, 30.29 -97.01, 161.01 52.76, 80.7 77.95, 168.41 out-out out 13.696 Saltbr-out 12.572 HRD-in -83.14, -55.33 72.79, 2.25 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.74 APE8-rot-na 30.57 APE67-dihe-in -72.04, -6.33 -47.66, -41.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.195 0.24 B 313 271 18 0 0 18 [[587, 856]] 1.0 3brb Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR PTK2 FAK1_HUMAN 2IJMB Q05397 414 689 1052.0 ADP:800 ATPlike Inactive DFGin 6.323 15.493 BLBminus -110.71, -163.98 67.21, 81.0 -117.82, 145.96 283.77, 97.43 -64.08, -51.52 in-out in 7.648 Saltbr-out 3.676 HRD-in -77.75, -52.2 82.75, -4.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -36.05 APE8-dihe-out -75.82, 46.85 APE8-rot-na 30.48 APE67-dihe-in -72.2, -5.65 -47.65, -46.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.699 None None None XRAY 2.187 0.211 0.271 B 281 261 15 0 0 15 [[422, 678]] 1.0 2ijm Homo sapiens TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 1MP8A Q05397 414 686 1052.0 ADP:800 ATPlike Inactive None 999.0 999.0 None -89.07, -172.44 90.39, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 7.446 Saltbr-in 3.097 HRD-in -74.41, -44.19 70.37, -1.26 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.38 APE8-dihe-in -79.05, 61.98 APE8-rot-na 29.35 APE67-dihe-in -62.59, -13.79 -46.47, -46.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.07 None None None XRAY 1.6 0.188 0.23 A 281 252 21 0 0 19 [[422, 678]] 1.0 1mp8 Homo sapiens TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR TYK2-2 TYK2_HUMAN 4GVJA P29597 889 1176 1187.0 ADP:61201 ATPlike Inactive DFGin 6.265 13.752 BLAminus -124.99, -169.67 58.4, 84.34 -100.6, 24.1 294.23, 90.13 -57.35, -28.35 in-in in 8.284 Saltbr-in 2.699 HRD-in -78.85, -48.62 71.47, -0.89 in-in-out SNCiio in-out ActLoopNT-in 2.842 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -90.25, 6.85 APE9-dihe-in -64.48, 128.39 APE8-dihe-in -76.05, 68.17 APE8-rot-na 27.93 APE67-dihe-in -72.65, -6.35 -49.95, -35.24 APE12-dist-na 9.968 APE11-dist-na 13.036 APE10-dist-na 9.649 APE9-dist-in 6.845 C936A,Q969A,E971A,K972A,C1142A None None XRAY 2.03 0.19 0.231 A 302 288 0 0 0 0 [[589, 868], [897, 1171]] 2.0 4gvj Homo sapiens TYR_TYK2-2_HUMAN TYR 9.4e-82 280.2 2 260 259 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
OTHER STT7 C1EBN1_MICCC 4IX4A C1EBN1 151 489 489.0 ADP:60601 none Inactive None 999.0 999.0 None -124.77, 172.55 68.64, 78.1 -90.38, 21.25 292.81, 157.07 -65.27, -19.84 none-na none 999.0 Saltbr-na 999.0 HRD-na-- -69.85, -47.17 71.62, 4.08 na-in-none SNCain in-none ActLoopNT-in 2.96 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.499 0.163 0.199 A 350 339 0 0 0 0 [[62, 488]] 1.0 4ix4 Micromonas commoda OTHER_STT7_MICCC CMGC 1.3e-08 61.8 104 156 81 337 338 339 341 343 0 0 0 315 317 316 318 0 0 0 0 0 0 0 0 0 0 Protein kinase domain-containing protein
OTHER STT7 C1EBN1_MICCC 4IX4B C1EBN1 151 489 489.0 ADP:60601 none Inactive None 999.0 999.0 None -124.06, 172.31 67.36, 81.18 -93.11, 18.85 292.92, 160.57 -65.85, -21.57 none-na none 999.0 Saltbr-na 999.0 HRD-na-- -69.18, -45.52 70.51, 2.0 na-in-none SNCain in-none ActLoopNT-in 2.953 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.499 0.163 0.199 B 350 339 0 0 0 0 [[62, 488]] 1.0 4ix4 Micromonas commoda OTHER_STT7_MICCC CMGC 1.3e-08 61.8 104 156 81 337 338 339 341 343 0 0 0 315 317 316 318 0 0 0 0 0 0 0 0 0 0 Protein kinase domain-containing protein
OTHER STT7 C1EBN1_MICCC 4IX6A C1EBN1 151 489 489.0 ADP:60601 none Inactive None 999.0 999.0 None -121.42, 171.38 68.63, 78.17 -88.85, 21.64 296.86, 161.4 -62.59, -24.51 none-na none 999.0 Saltbr-na 999.0 HRD-na-- -70.26, -46.59 73.56, 1.3 na-in-none SNCain in-none ActLoopNT-in 2.949 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.6 0.174 0.193 A 350 339 0 0 0 0 [[62, 488]] 1.0 4ix6 Micromonas commoda OTHER_STT7_MICCC CMGC 1.3e-08 61.8 104 156 81 337 338 339 341 343 0 0 0 315 317 316 318 0 0 0 0 0 0 0 0 0 0 Protein kinase domain-containing protein
OTHER STT7 C1EBN1_MICCC 4IX6B C1EBN1 151 489 489.0 ADP:60601 none Inactive None 999.0 999.0 None -120.88, 168.28 70.6, 77.38 -87.7, 20.1 294.13, 158.65 -62.82, -23.17 none-na none 999.0 Saltbr-na 999.0 HRD-na-- -69.85, -45.21 71.7, -0.13 na-in-none SNCain in-none ActLoopNT-in 2.967 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.6 0.174 0.193 B 350 339 0 0 0 0 [[62, 488]] 1.0 4ix6 Micromonas commoda OTHER_STT7_MICCC CMGC 1.3e-08 61.8 104 156 81 337 338 339 341 343 0 0 0 315 317 316 318 0 0 0 0 0 0 0 0 0 0 Protein kinase domain-containing protein
TKL RIPK A0A811MS43_9POAL 8HODA A0A811MS43 82 379 435.0 ADP:60401 ATPlike Inactive DFGin 5.833 13.373 BLBplus -121.78, 161.33 63.78, 18.48 -72.74, 142.38 54.34, 88.33 69.05, 9.41 out-out out 13.949 Saltbr-out 11.845 HRD-out -80.81, 162.08 -71.22, -39.02 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -63.8, 122.58 APE9-dihe-na 79.64, 3.1 APE8-dihe-in -72.72, 144.78 APE8-rot-out 54.39 APE67-dihe-out 108.47, -0.29 -117.76, 31.22 APE12-dist-out 17.577 APE11-dist-out 21.132 APE10-dist-out 20.091 APE9-dist-out 12.203 S262A,T263A None None XRAY 1.95 0.201 0.228 A 326 279 19 0 0 9 [[97, 377]] 1.0 8hod Miscanthus lutarioriparius TKL_RIPK_9POAL TKL 6.7e-60 208.9 4 266 263 245 246 247 249 251 133 149 153 225 227 226 228 287 275 270 269 268 267 266 265 264 179 non-specific serine/threonine protein kinase
AGC PRKACA KAPCA_MOUSE 4NTTB P05132 11 351 351.0 ADP:60401 ATPlike Inactive DFGin 6.542 14.88 ABAminus -93.85, -35.44 -119.41, 118.31 -113.9, 43.83 296.85, 78.9 -65.87, -49.34 in-none in 9.869 Saltbr-none 999.0 HRD-in -94.05, -37.34 60.44, 1.66 none-in-in SNCnii in-in ActLoopNT-in 2.787 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -166.4, 146.42 APE9-dihe-na 126.7, -158.4 APE8-dihe-in -116.99, 137.33 APE8-rot-in 273.8 APE67-dihe-in -64.02, -34.69 -52.94, -43.07 APE12-dist-in 7.713 APE11-dist-in 10.72 APE10-dist-in 5.298 APE9-dist-in 4.164 K8C TPO198,SEP339 TPO198,SEP339 XRAY 3.5 0.23 0.284 B 350 341 0 0 0 0 [[44, 298]] 1.0 4ntt Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4O21A P05132 16 351 351.0 ADP:60401 ATPlike Active DFGin 6.037 14.439 BLAminus -125.27, 173.53 70.53, 83.75 -96.26, 25.58 272.04, 54.28 -57.91, -27.19 in-in in 8.953 Saltbr-in 2.716 HRD-in -83.95, -57.84 75.15, 8.54 in-in-in SNCiii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.15, 164.3 APE9-dihe-na 125.14, -151.92 APE8-dihe-in -125.51, 129.66 APE8-rot-in 308.07 APE67-dihe-in -63.53, -19.17 -43.91, -48.76 APE12-dist-in 8.04 APE11-dist-in 11.46 APE10-dist-in 5.911 APE9-dist-in 3.451 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.95 0.17 0.215 A 342 336 0 0 0 0 [[44, 298]] 1.0 4o21 Mus musculus AGC_PRKACA_MOUSE AGC 1.4e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 1L3RE P05132 2 351 351.0 ADP:60381 ATPlike Active DFGin 5.754 14.44 BLAminus -119.14, -174.46 57.18, 81.19 -93.77, 20.31 270.88, 52.04 -50.0, -37.57 in-in in 9.023 Saltbr-in 2.792 HRD-in -82.45, -54.36 70.16, 7.26 in-in-in SNCiii in-in ActLoopNT-in 2.92 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.84, 161.06 APE9-dihe-na 132.7, -149.01 APE8-dihe-in -131.06, 132.91 APE8-rot-in 298.56 APE67-dihe-in -55.27, -27.25 -33.24, -62.94 APE12-dist-in 8.198 APE11-dist-in 11.233 APE10-dist-in 5.825 APE9-dist-in 3.368 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 2.0 0.205 0.232 E 350 341 0 0 0 0 [[44, 298]] 1.0 1l3r Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DH5A P05132 16 351 351.0 ADP:60403 ATPlike Active DFGin 6.121 14.339 BLAminus -125.12, -179.76 61.4, 85.13 -97.61, 27.77 279.05, 62.21 -46.99, -44.52 in-in in 9.043 Saltbr-in 2.552 HRD-in -77.92, -53.51 67.68, 1.05 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.88, 153.17 APE9-dihe-na 132.88, -161.89 APE8-dihe-in -112.07, 131.8 APE8-rot-in 304.21 APE67-dihe-in -57.01, -23.17 -41.47, -55.69 APE12-dist-in 8.219 APE11-dist-in 11.602 APE10-dist-in 6.071 APE9-dist-in 3.87 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.2 0.187 0.222 A 350 336 0 0 0 0 [[44, 298]] 1.0 4dh5 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 5JR7A P05132 14 351 351.0 ADP:60400 ATPlike Active DFGin 5.739 13.691 BLAminus -145.14, 176.28 64.37, 76.68 -85.75, 18.89 294.14, 59.99 -43.66, -41.86 in-in in 8.674 Saltbr-in 2.709 HRD-in -93.38, -54.67 74.91, 7.39 in-in-in SNCiii in-in ActLoopNT-in 2.945 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.46, 148.2 APE9-dihe-na 147.95, -159.28 APE8-dihe-in -109.66, 131.32 APE8-rot-in 258.88 APE67-dihe-in -65.5, -25.8 -38.64, -53.47 APE12-dist-in 8.014 APE11-dist-in 10.772 APE10-dist-in 5.528 APE9-dist-in 3.878 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.56 0.269 0.322 A 350 338 0 0 0 0 [[44, 298]] 1.0 5jr7 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 5JR7C P05132 14 351 351.0 ADP:60400 ATPlike Active DFGin 5.899 13.164 BLAminus -138.79, 176.44 54.89, 86.07 -89.1, 7.67 290.95, 62.79 -41.83, -37.01 in-in in 8.185 Saltbr-in 3.195 HRD-in -79.11, -50.37 72.48, -21.93 in-in-in SNCiii in-in ActLoopNT-in 2.819 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.28, 123.46 APE9-dihe-na 160.31, -160.86 APE8-dihe-in -110.49, 124.04 APE8-rot-in 311.35 APE67-dihe-in -70.47, -24.34 -45.9, -42.95 APE12-dist-in 8.163 APE11-dist-in 10.628 APE10-dist-in 5.002 APE9-dist-in 4.262 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.56 0.269 0.322 C 350 338 0 0 0 0 [[44, 298]] 1.0 5jr7 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 7UJXE P05132 16 351 351.0 ADP:60401 ATPlike Active DFGin 5.731 14.357 BLAminus -121.93, 179.51 64.92, 83.56 -91.91, 29.5 277.22, 63.03 -64.62, -28.12 in-in in 9.103 Saltbr-in 2.812 HRD-in -86.19, -57.72 74.11, 16.74 in-in-in SNCiii in-in ActLoopNT-in 2.931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.48, 155.47 APE9-dihe-na 127.23, -161.98 APE8-dihe-in -111.77, 133.52 APE8-rot-in 302.04 APE67-dihe-in -65.07, -18.97 -50.87, -44.77 APE12-dist-in 8.191 APE11-dist-in 11.5 APE10-dist-in 5.961 APE9-dist-in 4.008 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.4 0.133 0.176 E 350 336 0 0 0 0 [[44, 298]] 1.0 7ujx Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 7V0GE P05132 17 351 351.0 ADP:60401 ATPlike Active DFGin 5.739 14.319 BLAminus -119.5, 177.58 67.43, 82.74 -91.45, 25.21 276.8, 64.92 -62.46, -26.34 in-in in 9.07 Saltbr-in 2.802 HRD-in -88.93, -50.41 71.3, 15.33 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.52, 156.77 APE9-dihe-na 130.04, -162.37 APE8-dihe-in -114.97, 131.2 APE8-rot-in 299.52 APE67-dihe-in -60.0, -22.75 -47.18, -49.61 APE12-dist-in 8.174 APE11-dist-in 11.542 APE10-dist-in 6.037 APE9-dist-in 3.965 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.63 0.118 0.163 E 350 335 0 0 0 0 [[44, 298]] 1.0 7v0g Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IADA P05132 15 351 351.0 ADP:60403 ATPlike Active DFGin 5.658 14.362 BLAminus -130.04, -179.13 63.0, 77.66 -87.34, 22.78 276.11, 53.54 -55.12, -31.28 in-in in 9.085 Saltbr-in 2.83 HRD-in -93.22, -52.19 70.15, 14.14 in-in-in SNCiii in-in ActLoopNT-in 2.935 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.54, 160.6 APE9-dihe-na 133.65, -143.98 APE8-dihe-in -130.05, 134.5 APE8-rot-in 298.49 APE67-dihe-in -67.08, -22.74 -48.94, -44.54 APE12-dist-in 8.051 APE11-dist-in 11.55 APE10-dist-in 6.087 APE9-dist-in 3.521 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.9 0.189 0.243 A 356 337 0 0 0 0 [[44, 298]] 1.0 4iad Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IAFA P05132 16 351 351.0 ADP:60403 ATPlike Active DFGin 5.943 14.13 BLAminus -121.29, 178.82 64.06, 84.8 -98.0, 27.2 281.56, 65.38 -51.93, -33.25 in-in in 8.871 Saltbr-in 2.669 HRD-in -76.48, -53.65 65.3, 9.94 in-in-in SNCiii in-in ActLoopNT-in 2.974 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.4, 160.11 APE9-dihe-na 128.66, -151.44 APE8-dihe-in -123.86, 135.06 APE8-rot-in 298.27 APE67-dihe-in -57.84, -25.84 -42.55, -55.44 APE12-dist-in 8.163 APE11-dist-in 11.523 APE10-dist-in 5.973 APE9-dist-in 3.563 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.2 0.16 0.192 A 356 336 0 0 0 0 [[44, 298]] 1.0 4iaf Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IAIA P05132 16 351 351.0 ADP:60403 ATPlike Active DFGin 5.465 14.503 BLAminus -125.1, 176.4 64.24, 81.88 -90.74, 22.64 269.91, 49.4 -55.45, -35.99 in-in in 9.101 Saltbr-in 2.714 HRD-in -91.06, -49.32 68.79, 15.16 in-in-in SNCiii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.75, 156.86 APE9-dihe-na 141.29, -148.36 APE8-dihe-in -128.24, 130.8 APE8-rot-in 300.02 APE67-dihe-in -62.27, -23.0 -47.39, -47.75 APE12-dist-in 7.945 APE11-dist-in 11.458 APE10-dist-in 5.867 APE9-dist-in 3.608 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.55 0.171 0.209 A 356 336 0 0 0 0 [[44, 298]] 1.0 4iai Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IAKA P05132 15 351 351.0 ADP:60403 ATPlike Active DFGin 5.705 14.569 BLAminus -126.92, 179.61 63.08, 81.74 -90.27, 23.65 270.26, 53.44 -59.05, -31.45 in-in in 8.985 Saltbr-in 2.747 HRD-in -94.54, -49.89 67.85, 16.15 in-in-in SNCiii in-in ActLoopNT-in 2.91 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.92, 164.74 APE9-dihe-na 131.87, -148.57 APE8-dihe-in -130.85, 127.67 APE8-rot-in 297.68 APE67-dihe-in -61.28, -21.91 -43.91, -50.7 APE12-dist-in 7.962 APE11-dist-in 11.443 APE10-dist-in 5.979 APE9-dist-in 3.545 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.6 0.185 0.222 A 356 337 0 0 0 0 [[44, 298]] 1.0 4iak Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IAYA P05132 16 351 351.0 ADP:60403 ATPlike Active DFGin 5.806 14.257 BLAminus -131.74, 174.05 67.76, 85.89 -95.28, 20.31 273.12, 61.73 -48.17, -36.05 in-in in 9.039 Saltbr-in 2.941 HRD-in -89.87, -50.65 68.98, 10.01 in-in-in SNCiii in-in ActLoopNT-in 3.055 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.39, 159.46 APE9-dihe-na 132.54, -148.24 APE8-dihe-in -127.91, 130.95 APE8-rot-in 300.76 APE67-dihe-in -63.09, -19.35 -45.58, -49.88 APE12-dist-in 8.089 APE11-dist-in 11.466 APE10-dist-in 5.991 APE9-dist-in 3.823 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.0 0.182 0.227 A 356 336 0 0 0 0 [[44, 298]] 1.0 4iay Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IAZA P05132 15 351 351.0 ADP:60403 ATPlike Active DFGin 6.144 14.635 BLAminus -132.33, 171.23 62.84, 84.78 -94.94, 21.85 278.49, 61.31 -54.74, -28.93 in-in in 9.219 Saltbr-in 2.747 HRD-in -95.03, -54.93 73.76, 14.73 in-in-in SNCiii in-in ActLoopNT-in 3.017 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.57, 164.74 APE9-dihe-na 127.12, -150.82 APE8-dihe-in -127.02, 138.46 APE8-rot-in 303.51 APE67-dihe-in -63.11, -25.72 -51.71, -47.83 APE12-dist-in 7.963 APE11-dist-in 11.514 APE10-dist-in 5.979 APE9-dist-in 3.574 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.85 0.201 0.248 A 356 337 0 0 0 0 [[44, 298]] 1.0 4iaz Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IB0A P05132 15 351 351.0 ADP:60403 ATPlike Active DFGin 5.713 14.439 BLAminus -123.68, 176.86 65.62, 82.22 -94.42, 18.76 272.15, 51.12 -47.84, -35.86 in-in in 9.065 Saltbr-in 3.023 HRD-in -84.67, -55.05 71.31, 12.11 in-in-in SNCiii in-in ActLoopNT-in 2.886 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.67, 157.49 APE9-dihe-na 139.08, -144.95 APE8-dihe-in -131.16, 131.55 APE8-rot-in 306.17 APE67-dihe-in -61.31, -24.54 -46.0, -48.78 APE12-dist-in 8.059 APE11-dist-in 11.516 APE10-dist-in 5.969 APE9-dist-in 3.692 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.87 0.219 0.287 A 356 337 0 0 0 0 [[44, 298]] 1.0 4ib0 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IB1A P05132 14 351 351.0 ADP:60403 ATPlike Active DFGin 5.656 14.443 BLAminus -126.58, 171.72 66.62, 80.69 -90.79, 23.58 274.18, 53.88 -53.03, -31.34 in-in in 9.121 Saltbr-in 2.691 HRD-in -82.93, -51.49 69.93, 14.85 in-in-in SNCiii in-in ActLoopNT-in 2.98 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.64, 163.58 APE9-dihe-na 133.1, -151.37 APE8-dihe-in -125.38, 138.08 APE8-rot-in 304.1 APE67-dihe-in -60.15, -23.69 -50.01, -49.7 APE12-dist-in 7.96 APE11-dist-in 11.404 APE10-dist-in 5.961 APE9-dist-in 3.635 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.63 0.196 0.223 A 356 338 0 0 0 0 [[44, 298]] 1.0 4ib1 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IB3A P05132 13 351 351.0 ADP:60401 ATPlike Active DFGin 5.973 14.215 BLAminus -125.69, 173.12 66.37, 84.97 -98.59, 21.41 276.57, 60.51 -51.27, -29.52 in-in in 8.99 Saltbr-in 2.76 HRD-in -77.27, -49.79 61.58, 13.48 in-in-in SNCiii in-in ActLoopNT-in 2.869 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.06, 160.46 APE9-dihe-na 127.6, -161.57 APE8-dihe-in -110.98, 129.89 APE8-rot-in 305.68 APE67-dihe-in -58.89, -23.07 -39.61, -54.94 APE12-dist-in 8.078 APE11-dist-in 11.522 APE10-dist-in 5.923 APE9-dist-in 3.568 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.2 0.182 0.228 A 356 339 0 0 0 0 [[44, 298]] 1.0 4ib3 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4XW6A P05132 15 351 351.0 ADP:60403 ATPlike Active DFGin 5.982 14.431 BLAminus -130.68, 178.48 65.03, 84.15 -99.24, 23.41 276.01, 56.03 -60.45, -23.49 in-in in 9.15 Saltbr-in 2.735 HRD-in -94.59, -52.61 68.2, 15.9 in-in-in SNCiii in-in ActLoopNT-in 2.791 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.91, 154.59 APE9-dihe-na 136.7, -154.91 APE8-dihe-in -121.39, 127.95 APE8-rot-in 293.9 APE67-dihe-in -62.75, -24.38 -45.59, -46.76 APE12-dist-in 8.051 APE11-dist-in 11.632 APE10-dist-in 6.051 APE9-dist-in 3.787 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.9 0.186 0.265 A 356 337 0 0 0 0 [[44, 298]] 1.0 4xw6 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 6E21A P05132 16 351 351.0 ADP:60403 ATPlike Active DFGin 5.594 14.055 BLAminus -122.61, 176.37 63.02, 83.41 -94.2, 28.27 284.3, 46.09 -48.88, -41.13 in-in in 9.029 Saltbr-in 2.607 HRD-in -74.35, -56.8 67.48, 11.51 in-in-in SNCiii in-in ActLoopNT-in 2.907 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.7, 159.01 APE9-dihe-na 131.41, -152.84 APE8-dihe-in -125.29, 130.56 APE8-rot-in 303.23 APE67-dihe-in -58.42, -25.04 -35.36, -60.06 APE12-dist-in 8.043 APE11-dist-in 11.584 APE10-dist-in 6.022 APE9-dist-in 3.58 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.0 0.187 0.217 A 356 336 0 0 0 0 [[44, 298]] 1.0 6e21 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 1JBPE P05132 10 351 351.0 ADP:60381 ATPlike Inactive DFGin 6.128 14.034 BLAminus -131.98, 178.81 60.97, 83.81 -101.93, 15.49 276.81, 71.17 -55.35, -24.18 in-in in 8.869 Saltbr-in 2.749 HRD-out -93.99, 130.53 -128.02, 39.83 in-in-in SNCiii in-in ActLoopNT-in 2.886 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.07, 156.95 APE9-dihe-na 132.9, -168.64 APE8-dihe-in -109.4, 126.7 APE8-rot-in 297.85 APE67-dihe-in -61.28, -20.5 -33.82, -53.02 APE12-dist-in 8.121 APE11-dist-in 11.448 APE10-dist-in 6.013 APE9-dist-in 3.862 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.2 0.175 999.0 E 350 342 0 0 0 0 [[44, 298]] 1.0 1jbp Mus musculus AGC_PRKACA_MOUSE AGC 1.6e-94 321.9 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 1RDQE P05132 2 351 351.0 ADP:60599,ATP:60600 ATPlike,ATPlike Active DFGin 5.707 14.515 BLAminus -117.27, 178.71 64.74, 81.19 -90.07, 21.82 270.96, 52.48 -58.25, -31.62 in-in in 9.091 Saltbr-in 2.719 HRD-in -91.16, -53.36 73.19, 12.39 in-in-in SNCiii in-in ActLoopNT-in 2.936 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.91, 159.57 APE9-dihe-na 132.64, -151.85 APE8-dihe-in -127.7, 133.09 APE8-rot-in 298.45 APE67-dihe-in -59.33, -27.24 -47.42, -47.34 APE12-dist-in 8.116 APE11-dist-in 11.414 APE10-dist-in 5.831 APE9-dist-in 3.521 Y205A TPO198,SEP339 TPO198,SEP339 XRAY 1.26 0.132 0.162 E 350 342 0 0 0 0 [[44, 298]] 1.0 1rdq Mus musculus AGC_PRKACA_MOUSE AGC 1.1e-92 315.9 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4NTTA P05132 11 351 351.0 ADP:60401 ATPlike Inactive DFGin 6.255 15.221 None 58.0, -132.96 -135.23, 163.83 -122.73, 17.77 281.43, 74.72 -41.46, -50.2 in-out in 9.982 Saltbr-out 4.194 HRD-in -65.11, -40.77 60.9, 3.38 out-in-in SNCoii in-in ActLoopNT-in 2.864 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.9, 118.31 APE9-dihe-na 164.12, -173.28 APE8-dihe-in -108.19, 123.7 APE8-rot-in 267.93 APE67-dihe-in -75.4, -22.82 -40.35, -37.34 APE12-dist-in 8.188 APE11-dist-in 11.159 APE10-dist-in 5.542 APE9-dist-in 4.321 None TPO198,SEP339 TPO198,SEP339 XRAY 3.5 0.23 0.284 A 350 341 0 0 0 0 [[44, 298]] 1.0 4ntt Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CAMK CAMK2A KCC2A_MOUSE 7B57B P11798 5 307 478.0 ADP:603 ATPlike Active DFGin 6.612 14.081 BLAminus -127.42, 175.73 58.47, 86.34 -93.82, 26.41 288.57, 77.62 -63.18, -29.51 in-in in 8.79 Saltbr-in 2.799 HRD-in -66.41, -49.66 65.98, 1.57 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.13, 142.7 APE9-dihe-na 131.67, 177.43 APE8-dihe-in -91.43, 131.98 APE8-rot-in 302.75 APE67-dihe-in -62.31, -16.39 -48.04, -47.99 APE12-dist-in 10.368 APE11-dist-in 11.44 APE10-dist-in 5.743 APE9-dist-in 3.998 T305A,T306A None None XRAY 1.95 0.206 0.247 B 317 303 0 0 0 0 [[13, 271]] 1.0 7b57 Mus musculus CAMK_CAMK2A_MOUSE CAMK 1.7e-96 328.6 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CK1 CSNK1D KC1D_MOUSE 5X17A Q9DC28 3 292 415.0 ADP:307 Type1.5_Back Active DFGin 5.885 15.017 BLAminus -136.76, 176.51 70.17, 78.89 -96.78, 24.57 288.71, 93.09 -76.8, -15.99 in-in in 8.102 Saltbr-in 3.148 HRD-in -73.34, -55.18 81.19, 1.41 in-in-in SNCiii in-in ActLoopNT-in 2.824 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -69.47, -59.72 APE9-dihe-na -86.86, -154.47 APE8-dihe-in -76.87, 120.04 APE8-rot-in 308.55 APE67-dihe-in -51.63, -37.36 -55.73, -38.13 APE12-dist-in 10.457 APE11-dist-in 12.417 APE10-dist-in 6.378 APE9-dist-in 3.807 None None None XRAY 2.0 0.19 0.242 A 296 290 0 0 0 0 [[9, 275]] 1.0 5x17 Mus musculus CK1_CSNK1D_MOUSE CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_MOUSE 5X17B Q9DC28 4 292 415.0 ADP:306 Type1.5_Back Active DFGin 6.333 14.989 BLAminus -121.28, -179.96 69.25, 82.44 -101.59, 21.98 290.59, 89.01 -77.86, -17.5 in-in in 8.042 Saltbr-in 3.107 HRD-in -90.58, -48.35 72.79, 12.65 in-in-in SNCiii in-in ActLoopNT-in 2.76 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.44, 137.77 APE9-dihe-na 91.26, -171.32 APE8-dihe-in -91.08, 137.89 APE8-rot-in 301.79 APE67-dihe-in -58.2, -31.0 -69.62, -39.78 APE12-dist-in 12.297 APE11-dist-in 11.987 APE10-dist-in 6.492 APE9-dist-in 3.373 None None None XRAY 2.0 0.19 0.242 B 296 289 0 0 0 0 [[9, 275]] 1.0 5x17 Mus musculus CK1_CSNK1D_MOUSE CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CMGC GSK3B GSK3B_MOUSE 8VMFA Q9WV60 27 383 420.0 ADP:60504 ATPlike Active DFGin 6.612 14.1 BLAminus -148.4, -167.57 58.53, 66.72 -90.57, 24.21 287.49, 78.37 -75.04, -7.89 in-in in 8.66 Saltbr-in 2.678 HRD-in -67.34, -47.3 70.6, 6.45 in-in-in SNCiii in-in ActLoopNT-in 2.84 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -98.01, -20.74 APE9-dihe-na -93.16, -168.14 APE8-dihe-in -112.8, 164.36 APE8-rot-in 304.6 APE67-dihe-inflip 78.98, -8.38 -56.8, 140.56 APE12-dist-in 13.183 APE11-dist-in 10.949 APE10-dist-in 6.514 APE9-dist-in 3.308 None None None XRAY 2.5 0.21 0.251 A 364 354 0 0 0 0 [[56, 340]] 1.0 8vmf Mus musculus CMGC_GSK3B_MOUSE CMGC 2e-70 243.5 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_MOUSE 8VMGA Q9WV60 26 383 420.0 ADP:60401 ATPlike Active DFGin 7.0 13.999 BLAminus -139.67, -176.86 60.44, 73.06 -89.27, 27.07 283.1, 81.19 -73.23, -12.63 in-in in 8.478 Saltbr-in 2.688 HRD-in -67.64, -48.38 72.75, 3.36 in-in-in SNCiii in-in ActLoopNT-in 2.844 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.26, 164.63 APE9-dihe-na 72.45, 142.8 APE8-dihe-in -66.41, 146.08 APE8-rot-in 307.07 APE67-dihe-in -64.3, -22.81 -57.43, -46.54 APE12-dist-in 13.278 APE11-dist-in 11.627 APE10-dist-in 6.941 APE9-dist-in 2.984 None None None XRAY 2.45 0.195 0.23 A 364 358 0 0 0 0 [[56, 340]] 1.0 8vmg Mus musculus CMGC_GSK3B_MOUSE CMGC 2e-70 243.5 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_MOUSE 8VMEA Q9WV60 26 383 420.0 ADP:60401 ATPlike Active DFGin 6.469 13.844 BLAminus -131.0, -171.33 63.41, 73.0 -92.56, 22.88 289.27, 83.61 -79.03, -1.02 in-in in 8.753 Saltbr-in 2.78 HRD-in -67.9, -47.67 70.4, 7.52 in-in-in SNCiii in-in ActLoopNT-in 2.731 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.18, 168.01 APE9-dihe-na 68.83, 161.19 APE8-dihe-in -90.7, 152.54 APE8-rot-in 290.93 APE67-dihe-inflip 82.32, -22.26 -51.38, 150.9 APE12-dist-in 13.288 APE11-dist-in 12.071 APE10-dist-in 6.934 APE9-dist-in 3.292 None None None XRAY 2.3 0.183 0.23 A 365 355 0 0 0 0 [[56, 340]] 1.0 8vme Mus musculus CMGC_GSK3B_MOUSE CMGC 2.1e-70 243.5 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_MOUSE 4NU1A Q9WV60 6 383 420.0 ADP:405 ATPlike Active DFGin 6.109 13.677 BLAminus -140.27, -172.8 60.29, 88.19 -108.14, 24.39 289.57, 88.21 -68.01, -14.99 in-in in 8.691 Saltbr-in 2.793 HRD-in -66.76, -45.51 62.96, 19.85 in-in-in SNCiii in-in ActLoopNT-in 2.682 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.38, 172.68 APE9-dihe-na 66.76, 153.81 APE8-dihe-in -82.08, 156.46 APE8-rot-in 299.93 APE67-dihe-inflip 76.53, -25.22 -54.39, 158.45 APE12-dist-in 13.51 APE11-dist-in 11.621 APE10-dist-in 7.126 APE9-dist-in 3.15 None SEP9 SEP9 XRAY 2.5 0.194 0.245 A 389 357 2 0 0 0 [[56, 340]] 1.0 4nu1 Mus musculus CMGC_GSK3B_MOUSE CMGC 2.5e-70 243.2 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
OTHER ERN1 ERN1_MOUSE 4PL4B Q9EQY0 562 963 977.0 ADP:1001 ATPlike Inactive DFGin 7.393 13.497 BLBplus -131.17, -171.5 49.73, 22.15 -77.96, 172.77 53.0, 89.01 68.36, -18.97 out-out out 16.186 Saltbr-out 12.867 HRD-in -71.43, -56.11 80.63, -15.27 out-out-out SNCooo out-out ActLoopNT-out 10.3 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -71.5, 161.7 APE9-dihe-na 95.56, 170.85 APE8-dihe-in -126.15, 140.57 APE8-rot-in 313.23 APE67-dihe-inflip 115.41, -9.81 -59.18, 119.64 APE12-dist-none 999.0 APE11-dist-in 13.373 APE10-dist-out 8.963 APE9-dist-in 3.302 N772Y None None XRAY 3.0 0.213 0.276 B 435 384 18 0 0 12 [[571, 832]] 1.0 4pl4 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL4C Q9EQY0 562 963 977.0 ADP:1001 ATPlike Inactive DFGin 7.548 14.248 BLBplus -126.51, -173.84 57.1, 11.03 -79.33, 148.55 56.35, 128.67 90.22, -11.73 out-out out 16.972 Saltbr-out 13.449 HRD-in -87.09, -33.21 64.61, -28.11 out-out-out SNCooo out-out ActLoopNT-out 10.668 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioi APE10-dihe-na -75.07, 168.04 APE9-dihe-na 83.31, 160.45 APE8-dihe-in -117.06, 150.3 APE8-rot-out 84.63 APE67-dihe-inflip 114.33, -11.46 -59.41, 124.52 APE12-dist-none 999.0 APE11-dist-in 13.484 APE10-dist-out 8.449 APE9-dist-in 3.554 N772Y None None XRAY 3.0 0.213 0.276 C 435 384 18 0 0 12 [[571, 832]] 1.0 4pl4 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL4D Q9EQY0 562 961 977.0 ADP:1001 ATPlike Inactive DFGin 7.508 13.71 BLBplus -135.47, -173.14 51.5, 21.77 -87.04, 144.38 56.66, 114.14 91.93, -17.13 out-out out 15.979 Saltbr-out 13.34 HRD-in -83.86, -32.09 72.35, -48.88 out-out-out SNCooo out-out ActLoopNT-out 10.328 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -70.73, 154.49 APE9-dihe-na 96.39, -168.63 APE8-dihe-in -140.56, 130.56 APE8-rot-in 311.25 APE67-dihe-inflip 116.72, -15.16 -51.06, 117.77 APE12-dist-none 999.0 APE11-dist-in 13.97 APE10-dist-out 9.138 APE9-dist-in 3.922 N772Y None None XRAY 3.0 0.213 0.276 D 435 377 18 0 0 12 [[571, 832]] 1.0 4pl4 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL5B Q9EQY0 562 963 977.0 ADP:1001 ATPlike Inactive DFGin 7.455 13.937 BLBplus -129.37, -173.23 56.7, 18.18 -83.15, 166.18 46.51, 88.1 78.73, -17.65 out-out out 17.378 Saltbr-out 14.051 HRD-in -57.7, -43.88 69.49, -15.96 out-out-out SNCooo out-out ActLoopNT-out 10.048 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nioi APE10-dihe-na -68.77, 169.09 APE9-dihe-na 94.26, -167.14 APE8-dihe-in -147.72, 134.59 APE8-rot-in 292.91 APE67-dihe-out 142.49, -27.58 -41.24, 92.94 APE12-dist-none 999.0 APE11-dist-in 13.292 APE10-dist-out 8.446 APE9-dist-in 3.356 N772Y None None XRAY 3.4 0.225 0.285 B 435 383 19 0 0 13 [[571, 832]] 1.0 4pl5 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL5C Q9EQY0 562 963 977.0 ADP:1001 ATPlike Inactive DFGin 7.794 14.061 BLBplus -140.3, -178.86 59.78, 31.79 -102.25, 171.48 50.28, 80.31 73.36, 0.55 out-out out 16.852 Saltbr-out 12.634 HRD-in -71.26, -29.05 67.43, -40.0 out-out-out SNCooo out-out ActLoopNT-out 10.543 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -68.61, -176.62 APE9-dihe-na 79.33, -164.24 APE8-dihe-in -141.99, 145.59 APE8-rot-in 309.7 APE67-dihe-inflip 125.8, -7.43 -55.77, 102.3 APE12-dist-none 999.0 APE11-dist-in 13.684 APE10-dist-out 8.599 APE9-dist-in 3.649 N772Y None None XRAY 3.4 0.225 0.285 C 435 386 16 0 0 11 [[571, 832]] 1.0 4pl5 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL5D Q9EQY0 561 963 977.0 ADP:1001 ATPlike Inactive DFGin 6.883 13.709 BLBplus -149.88, 177.73 60.77, 34.53 -99.83, 170.66 50.74, 82.52 85.0, -30.32 out-out out 16.873 Saltbr-out 16.31 HRD-in -73.87, -31.52 63.42, -30.41 out-out-out SNCooo out-out ActLoopNT-out 10.862 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioi APE10-dihe-na -64.48, 167.99 APE9-dihe-na 99.63, 173.49 APE8-dihe-in -124.29, 140.67 APE8-rot-out 174.47 APE67-dihe-inflip 122.64, -17.06 -61.26, 114.95 APE12-dist-none 999.0 APE11-dist-in 13.232 APE10-dist-out 8.112 APE9-dist-in 3.919 N772Y None None XRAY 3.4 0.225 0.285 D 435 385 18 0 0 12 [[571, 832]] 1.0 4pl5 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL3A Q9EQY0 560 964 977.0 31J:1001,ADP:1002 Allosteric,ATPlike Inactive DFGin 7.327 13.716 BLBplus -137.83, -169.53 45.26, 38.38 -99.01, 160.39 56.61, 78.79 64.67, 4.33 out-out out 16.579 Saltbr-out 12.448 HRD-in -67.88, -49.57 75.5, 1.96 out-out-out SNCooo out-out ActLoopNT-out 9.693 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -56.59, -179.83 APE9-dihe-na 70.82, 169.1 APE8-dihe-in -122.85, 127.5 APE8-rot-in 297.91 APE67-dihe-inflip 117.64, -32.26 -39.31, 118.58 APE12-dist-none 999.0 APE11-dist-out 14.061 APE10-dist-out 9.312 APE9-dist-in 3.559 N772Y None None XRAY 2.9 0.202 0.234 A 435 388 17 0 0 12 [[571, 832]] 1.0 4pl3 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL3B Q9EQY0 562 963 977.0 31J:1001,ADP:1002 Allosteric,ATPlike Inactive DFGin 7.334 13.893 BLBplus -148.72, -173.45 55.21, 14.76 -81.6, 169.54 60.69, 84.7 79.59, -5.1 out-out out 16.58 Saltbr-out 13.289 HRD-in -77.64, -56.6 82.71, -30.85 out-out-out SNCooo out-out ActLoopNT-out 10.622 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -64.56, 166.09 APE9-dihe-na 91.33, -176.0 APE8-dihe-in -135.33, 135.79 APE8-rot-in 299.82 APE67-dihe-inflip 121.38, -25.98 -48.92, 119.9 APE12-dist-none 999.0 APE11-dist-out 14.123 APE10-dist-out 9.336 APE9-dist-in 3.695 N772Y None None XRAY 2.9 0.202 0.234 B 435 383 19 0 0 13 [[571, 832]] 1.0 4pl3 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL4A Q9EQY0 562 963 977.0 31K:1001,ADP:1002 Allosteric,ATPlike Inactive DFGin 6.788 14.219 BLBplus -105.14, -174.11 44.38, 29.11 -94.38, 143.46 69.8, 104.54 103.76, -33.08 out-out out 16.605 Saltbr-out 13.273 HRD-in -77.26, -47.59 71.94, -10.31 out-out-out SNCooo out-out ActLoopNT-out 10.563 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -61.91, 153.92 APE9-dihe-na 102.53, -174.53 APE8-dihe-in -133.87, 129.13 APE8-rot-in 297.04 APE67-dihe-inflip 119.89, -24.27 -52.28, 118.86 APE12-dist-none 999.0 APE11-dist-out 14.379 APE10-dist-out 9.432 APE9-dist-in 3.296 N772Y None None XRAY 3.0 0.213 0.276 A 435 385 17 0 0 11 [[571, 832]] 1.0 4pl4 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL5A Q9EQY0 562 964 977.0 31L:1001,ADP:1002,PEU:1004 Allosteric,ATPlike,Allosteric Inactive DFGin 6.585 13.755 BLBplus -127.28, -167.94 47.08, 28.46 -89.65, 160.5 62.46, 164.78 70.79, 0.93 out-out out 16.296 Saltbr-out 12.729 HRD-in -75.22, -42.28 71.55, -19.88 out-out-out SNCooo out-out ActLoopNT-out 10.486 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -69.09, -179.67 APE9-dihe-na 72.79, -173.9 APE8-dihe-in -128.85, 142.84 APE8-rot-in 291.98 APE67-dihe-inflip 114.76, -25.15 -48.2, 123.54 APE12-dist-none 999.0 APE11-dist-in 13.799 APE10-dist-out 8.597 APE9-dist-in 3.498 N772Y None None XRAY 3.4 0.225 0.285 A 435 386 17 0 0 12 [[571, 832]] 1.0 4pl5 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
TYR EPHB2 EPHB2_MOUSE 2HENA P54763 614 893 986.0 ADP:60400 ATPlike None DFGin 5.333 15.674 BLAminus -133.74, -165.91 59.29, 70.83 -103.82, 9.51 292.63, 82.7 -87.21, 999.0 in-in in 8.023 Saltbr-in 2.786 HRD-in -62.88, -49.36 74.49, -21.92 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 78.77 APE8-rot-na 327.53 APE67-dihe-in -57.52, -8.41 -44.64, -64.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 D746A None None XRAY 2.6 0.205 0.26 A 286 258 22 0 0 22 [[621, 882]] 1.0 2hen Mus musculus TYR_EPHB2_MOUSE TYR 7e-108 365.8 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR EPHB2 EPHB2_MOUSE 2HENB P54763 614 893 986.0 ADP:60401 ATPlike None DFGin 4.876 14.888 BLAminus -140.27, -169.83 69.21, 92.69 -125.5, 35.8 302.49, 84.21 -59.5, 999.0 in-in in 8.267 Saltbr-in 2.839 HRD-in -71.96, -52.85 76.51, -19.64 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 70.95 APE8-rot-na 35.68 APE67-dihe-in -63.04, 8.29 -53.0, -58.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 D746A None None XRAY 2.6 0.205 0.26 B 286 258 22 0 0 22 [[621, 882]] 1.0 2hen Mus musculus TYR_EPHB2_MOUSE TYR 7e-108 365.8 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR EPHB2 EPHB2_MOUSE 2HENC P54763 614 893 986.0 ADP:60402 ATPlike None DFGin 5.167 15.787 BLAminus -136.6, -161.63 61.14, 70.93 -108.31, 8.65 286.35, 98.46 -79.82, 999.0 in-in in 8.074 Saltbr-in 2.876 HRD-in -60.04, -43.18 71.33, -24.11 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 75.37 APE8-rot-na 329.62 APE67-dihe-in -67.84, -7.2 -58.96, -40.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 D746A None None XRAY 2.6 0.205 0.26 C 286 258 22 0 0 22 [[621, 882]] 1.0 2hen Mus musculus TYR_EPHB2_MOUSE TYR 7e-108 365.8 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR EPHB2 EPHB2_MOUSE 2HEND P54763 614 893 986.0 ADP:60403 ATPlike None DFGin 4.79 14.772 BLAminus -150.33, -176.71 75.96, 94.04 -126.18, 89.85 307.58, 79.07 -67.67, 999.0 in-in in 8.322 Saltbr-in 3.409 HRD-in -71.43, -49.79 75.74, -24.02 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 92.49 APE8-rot-na 333.13 APE67-dihe-in -68.61, 6.13 -48.05, -54.94 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 D746A None None XRAY 2.6 0.205 0.26 D 286 258 22 0 0 22 [[621, 882]] 1.0 2hen Mus musculus TYR_EPHB2_MOUSE TYR 7e-108 365.8 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR JAK1-12 JAK1_MOUSE 7T6FA P52332 32 1153 1153.0 ADN:61201,ADP:61202 Allosteric,ATPlike Inactive DFGin 6.899 13.813 None -86.13, -125.98 -78.37, 170.67 -132.74, 42.36 300.4, 95.7 -63.52, -44.16 in-out in 8.266 Saltbr-out 5.345 HRD-in -74.55, -24.53 68.9, -7.15 out-in-out SNCoio in-out ActLoopNT-in 3.366 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -74.97, -30.61 APE9-dihe-in -69.86, 145.09 APE8-dihe-in -65.5, 154.45 APE8-rot-na 337.81 APE67-dihe-in -111.81, 34.03 -69.03, -47.03 APE12-dist-na 13.07 APE11-dist-na 13.989 APE10-dist-na 8.674 APE9-dist-in 6.36 None None None EM 3.6 999.0 999.0 A 1173 1043 23 0 0 0 [[582, 846], [874, 1150]] 2.0 7t6f Mus musculus TYR_JAK1-12_MOUSE TYR 7.5e-59 499.6 3 260 516 1019 1020 1021 1023 1025 907 924 928 999 1001 1000 1002 1062 1050 1045 1044 1043 1042 1041 1040 1039 956 Tyrosine-protein kinase JAK1
TYR JAK1-12 JAK1_MOUSE 7T6FB P52332 32 1153 1153.0 ADN:61201,ADP:61202 Allosteric,ATPlike Inactive DFGin 6.898 13.813 None -86.09, -125.95 -78.45, 170.72 -132.73, 42.29 300.45, 95.61 -63.42, -44.2 in-out in 8.267 Saltbr-out 5.347 HRD-in -74.65, -24.42 68.9, -7.11 out-in-out SNCoio in-out ActLoopNT-in 3.366 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -74.91, -30.65 APE9-dihe-in -69.79, 145.09 APE8-dihe-in -65.5, 154.47 APE8-rot-na 337.81 APE67-dihe-in -111.9, 34.05 -69.03, -46.98 APE12-dist-na 13.069 APE11-dist-na 13.989 APE10-dist-na 8.673 APE9-dist-in 6.36 None None None EM 3.6 999.0 999.0 B 1173 1043 23 0 0 0 [[582, 846], [874, 1150]] 2.0 7t6f Mus musculus TYR_JAK1-12_MOUSE TYR 7.5e-59 499.6 3 260 516 1019 1020 1021 1023 1025 907 924 928 999 1001 1000 1002 1062 1050 1045 1044 1043 1042 1041 1040 1039 956 Tyrosine-protein kinase JAK1
TYR JAK1-12 JAK1_MOUSE 8EWYA P52332 32 1153 1153.0 ADN:61201,ADP:61202 Allosteric,ATPlike Inactive None 999.0 999.0 None -138.68, -158.74 57.84, 53.41 -86.5, 17.2 999.0, 999.0 -66.33, -21.83 in-none in 8.079 Saltbr-none 999.0 HRD-in -63.86, -38.24 65.99, -1.42 none-in-in SNCnii in-in ActLoopNT-in 2.841 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.88, 139.03 APE9-dihe-in -137.63, 148.1 APE8-dihe-in -70.82, 80.23 APE8-rot-na 999.0 APE67-dihe-in -71.32, -12.38 -60.07, -30.97 APE12-dist-na 13.002 APE11-dist-na 7.928 APE10-dist-na 11.009 APE9-dist-in 6.342 V657F None None EM 5.5 999.0 999.0 A 1173 1047 19 0 0 0 [[582, 846], [874, 1150]] 2.0 8ewy Mus musculus TYR_JAK1-12_MOUSE TYR 7.5e-59 499.6 3 260 516 1019 1020 1021 1023 1025 907 924 928 999 1001 1000 1002 1062 1050 1045 1044 1043 1042 1041 1040 1039 956 Tyrosine-protein kinase JAK1
TYR JAK1-12 JAK1_MOUSE 8EWYB P52332 32 1153 1153.0 ADN:61201,ADP:61202 Allosteric,ATPlike Inactive None 999.0 999.0 None -138.65, -158.76 57.86, 53.37 -86.37, 17.05 999.0, 999.0 -66.24, -21.9 in-none in 8.079 Saltbr-none 999.0 HRD-in -63.87, -38.25 66.06, -1.5 none-in-in SNCnii in-in ActLoopNT-in 2.842 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.87, 139.06 APE9-dihe-in -137.62, 148.16 APE8-dihe-in -70.91, 80.26 APE8-rot-na 999.0 APE67-dihe-in -71.25, -12.38 -60.08, -31.01 APE12-dist-na 13.002 APE11-dist-na 7.928 APE10-dist-na 11.009 APE9-dist-in 6.341 V657F None None EM 5.5 999.0 999.0 B 1173 1047 19 0 0 0 [[582, 846], [874, 1150]] 2.0 8ewy Mus musculus TYR_JAK1-12_MOUSE TYR 7.5e-59 499.6 3 260 516 1019 1020 1021 1023 1025 907 924 928 999 1001 1000 1002 1062 1050 1045 1044 1043 1042 1041 1040 1039 956 Tyrosine-protein kinase JAK1
TYR SRC SRC_MOUSE 8XN8A P05480 85 534 535.0 ADP:601 ATPlike Inactive DFGin 5.828 13.233 BLBplus -120.06, 161.26 65.68, 32.74 -74.22, 143.59 39.08, 88.47 84.86, -35.8 out-out out 13.986 Saltbr-out 13.922 HRD-in -73.69, -59.12 84.41, -7.57 out-out-out SNCooo out-out ActLoopNT-out 7.405 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.24, -6.02 APE9-dihe-in -94.54, 127.69 APE8-dihe-in -80.44, 65.55 APE8-rot-na 33.74 APE67-dihe-in -67.14, -17.8 -57.51, -33.8 APE12-dist-na 17.699 APE11-dist-na 18.558 APE10-dist-na 13.373 APE9-dist-out 8.71 None PTR529 PTR529 XRAY 1.95 0.187 0.224 A 451 450 0 0 0 0 [[269, 520]] 1.0 8xn8 Mus musculus TYR_SRC_MOUSE TYR 8.8e-94 319.8 1 260 260 405 406 407 409 411 297 312 316 385 387 386 388 446 434 429 428 427 426 425 424 423 341 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_MOUSE 6F3FA P05480 85 531 535.0 ADP:60601 ATPlike Inactive DFGin 5.729 13.263 BLBplus -129.36, 166.09 58.36, 35.58 -80.98, 135.75 39.82, 82.45 82.86, -9.54 out-out out 14.175 Saltbr-out 14.398 HRD-in -79.21, -57.39 83.57, -8.9 out-out-out SNCooo out-out ActLoopNT-out 7.29 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -111.04, 2.76 APE9-dihe-in -98.67, 129.97 APE8-dihe-in -74.19, 70.52 APE8-rot-na 30.31 APE67-dihe-in -76.25, -9.79 -62.62, -30.23 APE12-dist-na 17.526 APE11-dist-na 18.723 APE10-dist-na 13.526 APE9-dist-out 8.548 None PTR529 PTR529 XRAY 2.418 0.211 0.268 A 455 447 0 0 0 0 [[269, 520]] 1.0 6f3f Mus musculus TYR_SRC_MOUSE TYR 9e-94 319.7 1 260 260 405 406 407 409 411 297 312 316 385 387 386 388 446 434 429 428 427 426 425 424 423 341 Proto-oncogene tyrosine-protein kinase Src
OTHER PKNB PKNB_MYCTU 3F61A P9WI81 1 290 626.0 ADP:340 ATPlike Inactive DFGin 10.408 16.823 BLBminus -141.07, 168.15 65.97, 58.12 -87.1, 145.62 281.84, 72.93 89.1, 11.07 in-out in 9.933 Saltbr-out 6.777 HRD-in -66.51, -54.56 82.27, -14.45 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -63.4, -20.65 999.0, 0.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 L33D,V222D None None XRAY 1.8 0.205 0.228 A 311 271 19 0 0 19 [[11, 273]] 1.0 3f61 Mycobacterium tuberculosis OTHER_PKNB_MYCTU CAMK 1.6e-46 164.7 1 248 248 155 156 157 159 161 40 59 63 135 137 136 138 198 186 181 180 179 178 177 176 175 93 Serine/threonine-protein kinase PknB
OTHER PKNG PKNG_MYCTU 4Y0XA P9WI73 83 404 750.0 ADP:501 ATPlike Inactive DFGin 6.727 11.534 BLAminus -117.75, -169.01 53.44, 71.03 -83.15, 12.14 305.33, 8.75 -59.16, -32.06 out-out out 15.116 Saltbr-out 15.059 HRD-in -73.44, -41.15 68.04, -13.32 out-in-out SNCoio in-out ActLoopNT-in 2.777 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -55.23, 147.28 APE9-dihe-na -174.26, 176.21 APE8-dihe-in -98.04, 125.35 APE8-rot-in 298.01 APE67-dihe-inflip 105.55, -13.26 -56.87, 129.33 APE12-dist-out 5.542 APE11-dist-in 10.154 APE10-dist-in 7.371 APE9-dist-in 5.79 None None None XRAY 1.74 0.198 0.209 A 375 322 0 0 0 0 [[151, 345]] 1.0 4y0x Mycobacterium tuberculosis OTHER_PKNG_MYCTU CAMK 8.2e-22 86.0 1 186 186 292 293 294 296 298 181 198 202 273 275 274 276 327 316 311 310 309 308 307 306 305 233 Serine/threonine-protein kinase PknG
OTHER PKNI PKNI_MYCTU 5M06B P9WI69 2 255 585.0 ADP:301 ATPlike Inactive DFGin 8.316 16.631 BLBminus -112.52, 166.29 60.43, 51.53 -60.28, 125.48 270.62, 84.02 56.24, 31.01 out-out out 14.989 Saltbr-out 14.394 HRD-in -80.29, -52.43 77.96, -9.32 out-out-out SNCooo out-out ActLoopNT-out 11.53 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-out -70.34, -46.82 -66.42, 150.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.213 0.239 B 276 248 3 0 0 0 [[12, 175]] 1.0 5m06 Mycobacterium tuberculosis OTHER_PKNI_MYCTU CAMK 1.3e-18 76.4 1 201 201 158 159 160 162 164 41 60 64 134 136 135 137 184 172 167 166 0 0 0 0 0 90 Serine/threonine-protein kinase PknI
STE MAP2K1 MP2K1_RABIT 7JUQC P29678 40 381 393.0 ADP:401 ATPlike Inactive DFGin 6.586 14.742 BLBplus -129.84, -170.1 45.36, 32.9 -86.02, 164.53 43.64, 99.66 -81.97, 72.94 out-out out 15.573 Saltbr-out 14.639 HRD-in -71.73, -54.6 83.98, -10.27 out-out-out SNCooo out-out ActLoopNT-out 9.817 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -103.97, 121.68 APE9-dihe-na -107.28, -138.86 APE8-dihe-out -101.2, -25.18 APE8-rot-out 36.43 APE67-dihe-out -125.05, 133.16 -97.84, 131.49 APE12-dist-out 16.466 APE11-dist-out 18.834 APE10-dist-out 20.472 APE9-dist-out 14.688 None None None XRAY 3.22 0.256 0.288 C 384 305 37 0 0 0 [[68, 361]] 1.0 7juq Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
OTHER FLS2 FLS2_ORYSJ 8JUVA Q0JA29 861 1178 1183.0 ADP:60601 ATPlike Inactive DFGin 6.15 14.327 BLAminus -130.59, 177.4 65.69, 86.01 -100.39, 23.88 290.69, 79.09 -65.0, -14.14 in-in in 8.025 Saltbr-in 2.76 HRD-in -70.78, -47.74 78.11, -0.08 in-in-out SNCiio in-out ActLoopNT-in 2.747 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -103.82, 168.59 APE9-dihe-na 62.78, -132.62 APE8-dihe-out -74.57, -16.63 APE8-rot-out 44.07 APE67-dihe-in -63.03, -19.63 -66.3, -33.92 APE12-dist-out 23.725 APE11-dist-out 18.691 APE10-dist-out 19.68 APE9-dist-out 12.255 None None MSE903,MSE959,MSE1037,MSE1066,MSE1073,MSE1090,MSE1134,MSE1166,MSE1176 XRAY 2.09 0.183 0.208 A 339 288 30 0 0 16 [[874, 1175]] 1.0 8juv Oryza sativa OTHER_FLS2_ORYSJ TKL 3.7e-44 157.3 4 265 262 1030 1031 1032 1034 1036 908 926 930 1010 1012 1011 1013 1081 1069 1064 1063 1062 1061 1060 1059 1058 957 LRR receptor-like serine/threonine-protein kinase FLS2
OTHER PINK1 PINK1_PEDHC 8UYIA E0W1I1 120 572 575.0 ADP:601 ATPlike Active DFGin 9.472 14.492 BLAminus -126.54, -170.24 58.08, 66.04 -87.71, 25.91 289.34, 85.25 -66.89, -21.8 in-in in 7.734 Saltbr-in 2.489 HRD-in -72.82, -45.28 62.7, 4.34 in-in-in SNCiii in-in ActLoopNT-in 2.793 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na 149.48, -127.57 APE9-dihe-na -109.63, -105.35 APE8-dihe-in -70.24, 160.24 APE8-rot-na 51.46 APE67-dihe-in -90.34, -42.74 -107.64, 8.21 APE12-dist-in 8.485 APE11-dist-in 10.413 APE10-dist-in 5.828 APE9-dist-in 3.643 None SEP202,TPO305 SEP202,TPO305 EM 3.13 999.0 999.0 A 463 369 49 0 0 0 [[64, 514]] 1.0 8uyi Pediculus humanus OTHER_PINK1_PEDHC PINK1 1e-86 297.1 4 367 364 356 357 358 360 362 193 214 218 331 333 332 334 408 390 385 384 383 382 381 380 379 291 Serine/threonine-protein kinase Pink1, mitochondrial
OTHER PINK1 PINK1_PEDHC 8UYIB E0W1I1 122 574 575.0 ADP:601 ATPlike Active DFGin 9.37 14.767 BLAminus -128.32, -168.79 58.11, 64.54 -83.54, 12.33 278.78, 92.3 -66.63, -13.93 in-in in 8.001 Saltbr-in 2.363 HRD-in -66.42, -44.15 62.85, 2.17 in-in-in SNCiii in-in ActLoopNT-in 2.974 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na 143.29, -143.85 APE9-dihe-na -111.19, -100.88 APE8-dihe-in -71.36, 134.31 APE8-rot-na 50.34 APE67-dihe-in -67.38, -41.28 -74.79, -24.08 APE12-dist-in 8.473 APE11-dist-in 10.806 APE10-dist-in 6.227 APE9-dist-in 3.553 None SEP202,TPO305 SEP202,TPO305 EM 3.13 999.0 999.0 B 463 369 51 0 0 0 [[64, 514]] 1.0 8uyi Pediculus humanus OTHER_PINK1_PEDHC PINK1 1e-86 297.1 4 367 364 356 357 358 360 362 193 214 218 331 333 332 334 408 390 385 384 383 382 381 380 379 291 Serine/threonine-protein kinase Pink1, mitochondrial
AGC PRKACA KAPCA_RAT 3TNQB P27791 18 351 351.0 ADP:60400 ATPlike Inactive DFGin 6.026 14.109 ABAminus -114.77, -42.68 -116.73, 98.61 -86.63, 16.07 279.08, 57.74 -59.27, -13.09 in-in in 8.765 Saltbr-in 3.295 HRD-in -83.62, -53.15 67.05, 14.07 in-in-in SNCiii in-in ActLoopNT-in 3.015 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.54, 167.18 APE9-dihe-na 139.44, -131.54 APE8-dihe-in -144.99, 127.08 APE8-rot-in 312.05 APE67-dihe-in -55.59, -13.34 -44.48, -54.97 APE12-dist-in 8.095 APE11-dist-in 11.457 APE10-dist-in 6.181 APE9-dist-in 3.589 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 3.097 0.234 0.275 B 350 334 0 0 0 0 [[44, 298]] 1.0 3tnq Rattus norvegicus AGC_PRKACA_RAT AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CMGC MAPK1 MK01_RAT 4GVAA P63086 11 356 358.0 ADP:401 ATPlike Inactive DFGin 6.702 16.769 BLAminus -137.11, 178.59 63.89, 77.38 -94.14, 25.17 286.58, 79.57 -59.17, -35.22 out-out out 10.492 Saltbr-out 6.521 HRD-in -67.64, -55.15 72.72, 9.25 out-in-in SNCoii in-in ActLoopNT-in 2.83 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.68, -13.3 APE9-dihe-na -77.88, 161.53 APE8-dihe-in -56.04, 126.28 APE8-rot-in 320.84 APE67-dihe-in -66.77, -13.08 -47.2, -54.23 APE12-dist-in 13.845 APE11-dist-in 11.05 APE10-dist-in 7.148 APE9-dist-in 4.198 None None CME159 XRAY 1.83 0.191 0.241 A 364 346 0 0 0 0 [[23, 311]] 1.0 4gva Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.4e-85 293.1 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC FUS3 FUS3_YEAST 2B9HA P16892 1 353 353.0 ADP:500 ATPlike Inactive DFGin 6.283 13.764 BLAminus -136.62, -177.7 68.6, 65.84 -94.91, 10.48 297.74, 102.72 -75.81, -10.99 in-in in 8.564 Saltbr-in 2.732 HRD-in -74.04, -48.55 74.11, -6.87 in-in-out SNCiio in-out ActLoopNT-in 2.932 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -116.55, 132.5 APE9-dihe-na -63.29, 147.56 APE8-dihe-in -50.7, 127.74 APE8-rot-in 296.79 APE67-dihe-in -63.13, -20.59 -60.61, -24.81 APE12-dist-in 8.605 APE11-dist-out 6.693 APE10-dist-out 9.836 APE9-dist-in 4.75 T180V,Y182F None None XRAY 1.55 0.187 0.216 A 353 337 16 0 0 16 [[13, 309]] 1.0 2b9h Saccharomyces cerevisiae CMGC_FUS3_YEAST CMGC 2.2e-73 253.2 3 301 299 154 155 156 158 160 42 59 63 134 136 135 137 205 192 187 186 185 184 183 182 181 94 Mitogen-activated protein kinase FUS3
CMGC FUS3 FUS3_YEAST 2B9IA P16892 1 353 353.0 ADP:500 ATPlike Inactive DFGin 6.365 14.066 BLAminus -135.63, 178.36 68.62, 72.5 -98.81, 8.36 296.13, 97.35 -58.15, -32.2 in-in in 8.702 Saltbr-in 2.95 HRD-in -67.33, -47.39 70.79, -9.55 in-in-out SNCiio in-out ActLoopNT-in 2.954 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -112.27, 137.29 APE9-dihe-na -73.31, 133.1 APE8-dihe-in -36.03, 128.5 APE8-rot-in 289.53 APE67-dihe-in -68.8, -14.68 -68.0, -19.59 APE12-dist-in 8.905 APE11-dist-out 6.581 APE10-dist-out 9.961 APE9-dist-in 4.55 T180V,Y182F None None XRAY 2.5 0.202 0.279 A 353 338 15 0 0 15 [[13, 309]] 1.0 2b9i Saccharomyces cerevisiae CMGC_FUS3_YEAST CMGC 2.2e-73 253.2 3 301 299 154 155 156 158 160 42 59 63 134 136 135 137 205 192 187 186 185 184 183 182 181 94 Mitogen-activated protein kinase FUS3
CMGC FUS3 FUS3_YEAST 2B9JA P16892 1 353 353.0 ADP:500 ATPlike Inactive DFGin 6.547 13.868 BLAminus -134.9, -176.68 60.68, 67.3 -98.24, 14.73 302.06, 96.25 -69.67, -26.86 in-in in 8.701 Saltbr-in 2.96 HRD-in -72.32, -48.06 70.0, -6.29 in-in-out SNCiio in-out ActLoopNT-in 2.966 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -102.32, 139.79 APE9-dihe-na -71.76, 150.07 APE8-dihe-in -56.91, 118.63 APE8-rot-in 300.43 APE67-dihe-in -59.09, -25.02 -50.5, -31.25 APE12-dist-in 8.853 APE11-dist-out 6.593 APE10-dist-out 10.065 APE9-dist-in 4.766 T180V,Y182F None None XRAY 2.3 0.196 0.263 A 353 337 16 0 0 16 [[13, 309]] 1.0 2b9j Saccharomyces cerevisiae CMGC_FUS3_YEAST CMGC 2.2e-73 253.2 3 301 299 154 155 156 158 160 42 59 63 134 136 135 137 205 192 187 186 185 184 183 182 181 94 Mitogen-activated protein kinase FUS3
CMGC FUS3 FUS3_YEAST 2B9FA P16892 1 353 353.0 ADP:500 ATPlike Inactive DFGin 6.319 13.814 BLAminus -136.19, -174.38 64.52, 61.38 -89.09, 7.19 299.63, 104.82 -67.16, -21.09 in-in in 8.611 Saltbr-in 2.683 HRD-in -75.04, -47.21 75.53, -13.96 in-in-out SNCiio in-out ActLoopNT-in 3.045 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -129.66, 156.16 APE9-dihe-na -66.55, 158.23 APE8-dihe-in -56.07, 140.2 APE8-rot-in 288.73 APE67-dihe-in -58.7, -27.3 -59.52, -33.17 APE12-dist-in 8.681 APE11-dist-out 5.798 APE10-dist-out 8.573 APE9-dist-in 4.092 None None None XRAY 1.8 0.213 0.259 A 353 337 16 0 0 16 [[13, 309]] 1.0 2b9f Saccharomyces cerevisiae CMGC_FUS3_YEAST CMGC 5.2e-75 258.5 3 301 299 154 155 156 158 160 42 59 63 134 136 135 137 205 192 187 186 185 184 183 182 181 94 Mitogen-activated protein kinase FUS3
CMGC FUS3 FUS3_YEAST 2F9GA P16892 1 353 353.0 ADP:500 ATPlike None DFGin 6.607 14.033 BLAminus -131.87, -173.96 62.19, 67.37 -94.01, 7.54 292.42, 102.61 -61.43, -28.32 in-in in 8.738 Saltbr-in 2.766 HRD-in -77.05, -50.83 75.67, -3.23 in-in-none SNCiin in-none ActLoopNT-in 2.955 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.43 APE8-rot-in 296.4 APE67-dihe-in -62.22, -26.66 -58.62, -16.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None PTR182 PTR182 XRAY 2.1 0.211 0.26 A 353 332 21 0 0 21 [[13, 309]] 1.0 2f9g Saccharomyces cerevisiae CMGC_FUS3_YEAST CMGC 5.2e-75 258.5 3 301 299 154 155 156 158 160 42 59 63 134 136 135 137 205 192 187 186 185 184 183 182 181 94 Mitogen-activated protein kinase FUS3
CMGC KIN28 KIN28_YEAST 6XI8A P06242 6 303 306.0 ADP:401 ATPlike Inactive DFGin 5.502 15.444 BLAminus -145.77, -169.62 57.83, 69.55 -84.3, 48.2 280.55, 74.99 -75.72, -28.64 in-out in 8.952 Saltbr-out 3.667 HRD-out 58.01, 71.8 -89.69, 32.34 out-in-out SNCoio in-out ActLoopNT-in 2.701 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -116.0, -16.75 APE9-dihe-na -128.02, 157.65 APE8-dihe-in -70.96, 169.95 APE8-rot-out 44.23 APE67-dihe-in -79.03, -7.97 -69.89, -44.72 APE12-dist-in 12.387 APE11-dist-in 10.704 APE10-dist-in 6.15 APE9-dist-in 3.44 None TPO162 TPO162 EM 3.64 999.0 999.0 A 301 290 8 0 0 0 [[7, 290]] 1.0 6xi8 Saccharomyces cerevisiae CMGC_KIN28_YEAST CMGC 4.1e-70 242.3 1 301 301 146 147 148 150 152 36 54 58 126 128 127 129 187 174 169 168 167 166 165 164 163 84 Serine/threonine-protein kinase KIN28
CMGC KIN28 KIN28_YEAST 7KUEA P06242 6 303 306.0 ADP:401 ATPlike Inactive DFGin 5.502 15.444 BLAminus -145.81, -169.57 57.84, 69.51 -84.28, 48.19 280.53, 74.97 -75.72, -28.63 in-out in 8.952 Saltbr-out 3.667 HRD-out 58.03, 71.82 -89.76, 32.34 out-in-out SNCoio in-out ActLoopNT-in 2.702 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -115.99, -16.84 APE9-dihe-na -127.96, 157.63 APE8-dihe-in -70.94, 169.94 APE8-rot-out 44.25 APE67-dihe-in -79.07, -7.97 -69.92, -44.62 APE12-dist-in 12.386 APE11-dist-in 10.705 APE10-dist-in 6.15 APE9-dist-in 3.44 None TPO162 TPO162 EM 3.5 999.0 999.0 A 306 290 8 0 0 0 [[7, 290]] 1.0 7kue Saccharomyces cerevisiae CMGC_KIN28_YEAST CMGC 4.4e-70 242.3 1 301 301 146 147 148 150 152 36 54 58 126 128 127 129 187 174 169 168 167 166 165 164 163 84 Serine/threonine-protein kinase KIN28
CMGC SKY1 SKY1_YEAST 1Q8YA Q03656 144 737 742.0 ADP:60810 ATPlike Active DFGin 5.554 12.776 BLAminus -120.8, -179.55 50.32, 80.87 -92.72, 24.06 294.38, 19.86 -63.4, -18.16 in-in in 8.712 Saltbr-in 2.74 HRD-in -75.73, -45.78 71.18, -6.61 in-in-in SNCiii in-in ActLoopNT-in 2.965 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.41, 175.98 APE9-dihe-na 63.08, 152.12 APE8-dihe-in -90.87, 131.26 APE8-rot-in 290.95 APE67-dihe-in -56.18, -26.85 -9.03, -76.03 APE12-dist-in 12.534 APE11-dist-in 10.496 APE10-dist-in 7.507 APE9-dist-in 2.99 None None None XRAY 2.05 0.209 0.244 A 373 351 11 0 0 0 [[158, 706]] 1.0 1q8y Saccharomyces cerevisiae CMGC_SKY1_YEAST CMGC 8.8e-100 339.7 1 301 301 549 550 551 553 555 187 202 206 291 293 292 294 586 574 569 568 567 566 565 564 563 247 Serine/threonine-protein kinase SKY1
OTHER BUD32 BUD32_YEAST 4WW9A P53323 4 259 261.0 ADP:302 ATPlike Active DFGin 6.618 15.283 BLAminus -128.14, 172.87 62.95, 73.82 -100.2, 23.36 281.69, 91.54 -52.55, -36.42 in-in in 7.602 Saltbr-in 2.744 HRD-in -80.98, -51.42 97.59, -12.36 in-in-na SNCiia in-na ActLoopNT-in 2.852 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -61.46, -46.34 APE9-dihe-na -60.52, -40.33 APE8-dihe-na -68.91, -38.47 APE8-rot-na 168.71 APE67-dihe-na -62.48, -38.16 -54.4, -51.68 APE12-dist-na 15.732 APE11-dist-na 11.179 APE10-dist-na 14.687 APE9-dist-na 11.734 None None None XRAY 1.951 0.18 0.209 A 261 238 20 0 0 0 [[17, 261]] 1.0 4ww9 Saccharomyces cerevisiae OTHER_BUD32_YEAST TP53RK 5e-44 156.6 8 224 217 181 182 183 185 187 52 76 80 158 160 159 161 198 204 199 198 197 196 195 194 193 107 EKC/KEOPS complex subunit BUD32
OTHER CDC7 CDC7_YEAST 7PT78 P06243 10 475 507.0 ADP:1001,BEF:1003 ATPlike,Allosteric Inactive DFGin 7.05 14.828 ABAminus -125.48, -62.19 -62.72, 136.55 -132.76, 24.05 270.26, 81.1 -56.4, -43.64 in-out in 8.956 Saltbr-out 6.838 HRD-out -95.15, 91.19 -59.72, -45.2 out-in-out SNCoio in-out ActLoopNT-in 2.418 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiii APE10-dihe-na -63.65, 141.8 APE9-dihe-na 169.57, -141.23 APE8-dihe-in -138.07, 164.32 APE8-rot-in 301.9 APE67-dihe-out 82.72, -175.36 -64.25, 106.81 APE12-dist-in 8.854 APE11-dist-in 11.015 APE10-dist-in 5.043 APE9-dist-in 4.626 None None None EM 3.8 999.0 999.0 8 507 402 64 0 0 46 [[33, 469]] 1.0 7pt7 Saccharomyces cerevisiae OTHER_CDC7_YEAST CMGC 4e-17 121.0 1 158 260 181 182 183 185 187 76 90 94 160 162 161 163 301 288 283 282 281 280 279 278 277 121 Cell division control protein 7
OTHER IRE1 IRE1_YEAST 2RIOA P32361 665 1115 1115.0 ADP:61101 ATPlike None DFGin 5.032 14.666 BLAminus -125.01, -166.82 59.91, 72.41 -79.74, 13.1 278.94, 57.84 -50.86, -29.29 out-in out 10.36 Saltbr-in 3.544 HRD-in -69.38, -55.95 80.27, 5.91 in-in-none SNCiin in-none ActLoopNT-in 2.684 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 148.77 APE8-rot-in 240.38 APE67-dihe-in -59.81, -10.2 -102.36, 14.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.224 0.266 A 434 396 26 0 0 14 [[672, 977]] 1.0 2rio Saccharomyces cerevisiae OTHER_IRE1_YEAST TKL 1e-35 129.7 4 263 260 827 828 829 831 833 702 715 719 794 796 795 797 902 859 854 853 852 851 850 849 848 746 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER IRE1 IRE1_YEAST 2RIOB P32361 665 1115 1115.0 ADP:62101 ATPlike Inactive DFGin 5.132 14.401 BLAminus -133.23, -169.67 57.3, 77.4 -91.55, 18.06 279.67, 55.41 -50.86, -27.7 in-in in 9.967 Saltbr-in 3.554 HRD-in -79.44, -44.63 66.11, 11.75 in-in-out SNCiio in-out ActLoopNT-in 2.764 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 139.02 APE8-rot-out 206.66 APE67-dihe-in -67.78, -12.45 -143.81, 21.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.224 0.266 B 434 395 27 0 0 14 [[672, 977]] 1.0 2rio Saccharomyces cerevisiae OTHER_IRE1_YEAST TKL 1e-35 129.7 4 263 260 827 828 829 831 833 702 715 719 794 796 795 797 902 859 854 853 852 851 850 849 848 746 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER IRE1 IRE1_YEAST 3LJ0A P32361 665 1115 1115.0 ADP:2101,QUE:1 ATPlike,Allosteric None DFGin 5.657 14.52 BLAminus -127.75, -159.8 55.73, 76.2 -100.97, 26.65 278.19, 55.54 -68.42, -38.12 in-in in 9.315 Saltbr-in 3.043 HRD-in -75.54, -40.03 69.65, -11.03 in-in-none SNCiin in-none ActLoopNT-in 2.884 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -61.99 APE8-rot-none 999.0 APE67-dihe-in -81.59, -8.09 -104.48, 18.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP840,SEP841,TPO844 SEP840,SEP841,TPO844 XRAY 3.2 0.217 0.224 A 434 407 20 0 0 7 [[672, 977]] 1.0 3lj0 Saccharomyces cerevisiae OTHER_IRE1_YEAST TKL 1e-35 129.7 4 263 260 827 828 829 831 833 702 715 719 794 796 795 797 902 859 854 853 852 851 850 849 848 746 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER IRE1 IRE1_YEAST 3LJ0B P32361 670 1115 1115.0 ADP:2101,QUE:1 ATPlike,Allosteric None DFGin 5.639 14.529 BLAminus -127.76, -160.17 56.44, 75.29 -99.49, 26.48 278.86, 54.86 -67.91, -37.63 in-in in 9.332 Saltbr-in 3.088 HRD-in -76.48, -40.82 70.18, -10.34 in-in-none SNCiin in-none ActLoopNT-in 2.864 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -62.45 APE8-rot-in 292.53 APE67-dihe-in -81.7, -8.3 -104.03, 18.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP840,SEP841,TPO844 SEP840,SEP841,TPO844 XRAY 3.2 0.217 0.224 B 434 402 20 0 0 7 [[672, 977]] 1.0 3lj0 Saccharomyces cerevisiae OTHER_IRE1_YEAST TKL 1e-35 129.7 4 263 260 827 828 829 831 833 702 715 719 794 796 795 797 902 859 854 853 852 851 850 849 848 746 Serine/threonine-protein kinase/endoribonuclease IRE1
TYR VKR2 A0A3Q0KQ92_SCHMA 7ZVSA A0A3Q0KQ92 943 1257 1641.0 ADP:1301 ATPlike Inactive DFGin 6.411 13.912 ABAminus -108.2, -51.57 -108.14, 130.38 -125.76, 34.81 311.68, 99.72 -69.75, -23.67 in-out in 7.915 Saltbr-out 4.434 HRD-in -84.85, -39.64 60.03, 4.72 out-in-none SNCoin in-none ActLoopNT-in 3.115 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.51 APE8-dihe-in -86.18, 75.72 APE8-rot-na 32.5 APE67-dihe-in -65.42, -24.56 -66.74, -36.8 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.654 None None None XRAY 3.07 0.219 0.252 A 341 300 15 0 0 15 [[966, 1240]] 1.0 7zvs Schistosoma mansoni TYR_VKR2_SCHMA TYR 2.6e-69 239.5 1 253 253 1117 1118 1119 1121 1123 997 1014 1018 1097 1099 1098 1100 1162 1150 1145 1144 1143 1142 1141 1140 1139 1045 Guanylate cyclase
TYR VKR2 A0A3Q0KQ92_SCHMA 7ZVSB A0A3Q0KQ92 946 1257 1641.0 ADP:1301 ATPlike Inactive DFGin 6.622 14.521 ABAminus -98.3, -71.59 -103.46, 126.3 -111.19, 44.98 301.93, 110.43 -72.41, -47.73 in-in in 8.989 Saltbr-in 3.592 HRD-in -85.3, -43.46 65.5, -4.13 in-in-none SNCiin in-none ActLoopNT-in 3.168 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 149.82 APE9-dihe-in -99.67, 136.73 APE8-dihe-in -75.43, 94.78 APE8-rot-na 28.24 APE67-dihe-in -74.95, -28.65 -71.49, -32.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.774 APE9-dist-in 6.6 None None None XRAY 3.07 0.219 0.252 B 341 296 16 0 0 16 [[966, 1240]] 1.0 7zvs Schistosoma mansoni TYR_VKR2_SCHMA TYR 2.6e-69 239.5 1 253 253 1117 1118 1119 1121 1123 997 1014 1018 1097 1099 1098 1100 1162 1150 1145 1144 1143 1142 1141 1140 1139 1045 Guanylate cyclase
OTHER None A0ACD6BAW3_SERSF 5X1TA A0ACD6BAW3 11 298 302.0 ADP:401 ATPlike Inactive DFGin 5.685 14.725 ABAminus -97.25, -25.38 -172.38, 138.13 -106.62, 0.72 301.84, 142.37 67.65, 22.31 in-out in 9.742 Saltbr-out 4.566 HRD-in -80.43, -61.43 72.68, 8.5 out-out-out SNCooo out-out ActLoopNT-out 13.688 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oioo APE10-dihe-na -90.57, -68.65 APE9-dihe-na -94.13, 157.67 APE8-dihe-in -100.03, 111.72 APE8-rot-na 290.95 APE67-dihe-inflip 91.11, -26.21 -58.77, 131.47 APE12-dist-out 15.32 APE11-dist-in 10.432 APE10-dist-out 9.649 APE9-dist-out 6.242 None None None XRAY 1.55 0.203 0.229 A 302 283 5 0 0 0 [[23, 295]] 1.0 5x1t Serratia sp. OTHER_None_SERSF NEK 2.2e-22 86.3 1 248 248 182 183 184 186 188 52 89 93 162 164 163 165 225 210 205 204 203 202 201 200 199 119 PpkA N terminal
OTHER YOPO Q93KQ6_YEREN 5CE3B Q93KQ6 108 729 729.0 ADP:60801 ATPlike Inactive None 999.0 999.0 None -135.72, -178.29 65.55, 68.88 -88.43, 18.62 274.24, 50.39 -58.33, -41.28 none-na none 999.0 Saltbr-na 999.0 HRD-in -75.96, -46.65 74.34, -12.04 na-in-out SNCaio in-out ActLoopNT-in 2.931 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ooii APE10-dihe-na -168.45, -171.64 APE9-dihe-na -171.12, 163.26 APE8-dihe-in -100.11, 126.72 APE8-rot-in 306.6 APE67-dihe-in -62.68, -33.12 -66.23, -36.58 APE12-dist-out 6.894 APE11-dist-out 3.817 APE10-dist-in 5.185 APE9-dist-in 3.949 K205Y,E206Y,E207Y,K440Y,K441Y None None XRAY 2.93 0.198 0.24 B 643 598 0 0 0 0 [[144, 405]] 1.0 5ce3 Yersinia enterocolitica OTHER_YOPO_YEREN STE 4.1e-06 32.8 55 256 202 285 286 287 289 291 0 0 0 264 266 265 267 321 308 303 302 301 300 299 298 297 212 YopO
OTHER YOPO Q93KQ6_YEREN 5CE3D Q93KQ6 108 729 729.0 ADP:60801 ATPlike Inactive None 999.0 999.0 None -137.87, -178.9 65.7, 69.62 -87.46, 18.2 287.37, 172.47 -59.1, -40.66 none-na none 999.0 Saltbr-na 999.0 HRD-in -75.41, -46.8 73.5, -11.21 na-in-out SNCaio in-out ActLoopNT-in 2.923 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ooii APE10-dihe-na -169.34, -172.42 APE9-dihe-na -171.36, 163.27 APE8-dihe-in -100.95, 126.72 APE8-rot-in 306.77 APE67-dihe-in -63.23, -33.24 -66.66, -36.24 APE12-dist-out 6.877 APE11-dist-out 3.815 APE10-dist-in 5.173 APE9-dist-in 3.938 K205Y,E206Y,E207Y,K440Y,K441Y None None XRAY 2.93 0.198 0.24 D 643 598 0 0 0 0 [[144, 405]] 1.0 5ce3 Yersinia enterocolitica OTHER_YOPO_YEREN STE 4.1e-06 32.8 55 256 202 285 286 287 289 291 0 0 0 264 266 265 267 321 308 303 302 301 300 299 298 297 212 YopO

Ligand: ADP

Total number of chains: 112
Active chains: 46
Total number of genes: 37
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 78 69.6% 6EM7A
DFGin BLBplus 14 12.5% 8XN8A
None None 8 7.1% 4IX4A
DFGin ABAminus 6 5.4% 3TNQB
DFGin None 4 3.6% 5GZAA
DFGin BLBminus 2 1.8% 5M06B
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL BRI1 BRI1_ARATH 5LPBA O22476 867 1160 1196.0 ADP:1201 ATPlike Active DFGin 5.075 15.058 BLAminus -134.68, 179.03 63.17, 81.59 -99.15, 20.06 285.86, 73.26 -60.78, -23.17 in-in in 8.649 Saltbr-in 3.148 HRD-in -69.16, -46.8 71.42, -2.74 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -107.78, 147.47 APE9-dihe-na 145.38, -170.04 APE8-dihe-in -133.78, 133.64 APE8-rot-in 306.07 APE67-dihe-inflip 102.35, -15.45 -46.22, 126.04 APE12-dist-in 9.248 APE11-dist-in 11.275 APE10-dist-in 5.497 APE9-dist-in 3.743 T872A TPO1039,SEP1042,SEP1044,SEP1060 TPO1039,SEP1042,SEP1044,SEP1060 XRAY 1.98 0.184 0.203 A 296 284 10 0 0 0 [[882, 1157]] 1.0 5lpb Arabidopsis thaliana TKL_BRI1_ARATH TKL 2e-63 220.4 4 266 263 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL BRI1 BRI1_ARATH 5LPZA O22476 866 1160 1196.0 ADP:1200 ATPlike Active DFGin 5.281 15.229 BLAminus -133.61, -178.19 59.45, 71.09 -88.15, 19.11 288.53, 76.38 -60.79, -23.86 in-in in 8.633 Saltbr-in 2.829 HRD-in -68.17, -37.55 64.9, -2.92 in-in-in SNCiii in-in ActLoopNT-in 3.022 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -69.74, 170.98 APE9-dihe-na 106.33, 162.6 APE8-dihe-in -102.72, 137.46 APE8-rot-in 305.68 APE67-dihe-inflip 102.78, -18.56 -57.05, 134.59 APE12-dist-in 9.342 APE11-dist-in 11.755 APE10-dist-in 5.72 APE9-dist-in 3.579 T872A TPO1039,SEP1042,SEP1044 TPO1039,SEP1042,SEP1044 XRAY 2.48 0.226 0.253 A 332 286 9 0 0 0 [[882, 1157]] 1.0 5lpz Arabidopsis thaliana TKL_BRI1_ARATH TKL 3e-63 219.9 4 266 263 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL FERONIA FERON_ARATH 7XDXA Q9SCZ4 521 815 895.0 ADP:901 ATPlike Inactive DFGin 6.868 15.508 BLAminus -133.42, -178.74 67.64, 77.46 -97.26, 15.76 285.98, 88.34 -59.81, -31.94 in-out in 8.722 Saltbr-out 5.533 HRD-in -65.25, -47.87 74.08, 0.6 out-in-none SNCoin in-none ActLoopNT-in 2.762 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 135.64 APE8-rot-in 306.33 APE67-dihe-inflip 94.97, -23.67 -64.5, 138.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.23 0.184 0.235 A 313 280 15 0 0 15 [[535, 809]] 1.0 7xdx Arabidopsis thaliana TKL_FERONIA_ARATH TKL 2e-57 200.7 3 266 264 678 679 680 682 684 565 581 585 658 660 659 661 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
TKL FERONIA FERON_ARATH 7XDXB Q9SCZ4 521 815 895.0 ADP:901 ATPlike None DFGin 6.622 15.425 BLAminus -136.76, -177.06 63.7, 79.87 -96.73, 14.62 285.92, 71.87 -59.53, -21.5 in-in in 8.576 Saltbr-in 3.332 HRD-in -65.1, -49.82 75.49, 1.86 in-in-none SNCiin in-none ActLoopNT-in 2.737 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 136.01 APE8-rot-in 320.81 APE67-dihe-inflip 95.62, -22.56 -64.49, 139.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.23 0.184 0.235 B 313 280 15 0 0 15 [[535, 809]] 1.0 7xdx Arabidopsis thaliana TKL_FERONIA_ARATH TKL 2e-57 200.7 3 266 264 678 679 680 682 684 565 581 585 658 660 659 661 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
TKL FERONIA FERON_ARATH 7XDYA Q9SCZ4 521 815 895.0 ADP:901 ATPlike Inactive DFGin 6.759 15.786 BLAminus -141.78, -171.91 66.87, 59.86 -83.38, 11.19 284.91, 77.98 -59.88, -27.32 in-out in 8.886 Saltbr-out 5.604 HRD-in -63.61, -43.27 68.91, 0.58 out-in-none SNCoin in-none ActLoopNT-in 2.863 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 155.73 APE8-rot-in 307.09 APE67-dihe-inflip 97.81, -22.04 -77.29, 136.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.28 0.2 0.247 A 313 280 15 0 0 15 [[535, 809]] 1.0 7xdy Arabidopsis thaliana TKL_FERONIA_ARATH TKL 2e-57 200.7 3 266 264 678 679 680 682 684 565 581 585 658 660 659 661 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
TKL FERONIA FERON_ARATH 7XDYB Q9SCZ4 522 816 895.0 ADP:901 ATPlike Inactive DFGin 6.449 16.033 BLAminus -144.23, -178.13 65.87, 74.19 -94.93, 27.11 292.01, 67.35 -65.38, -32.71 in-out in 9.349 Saltbr-out 6.079 HRD-in -72.36, -52.52 79.98, -11.0 out-in-out SNCoio in-out ActLoopNT-in 2.784 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -15.92 APE8-rot-out 172.5 APE67-dihe-in -79.26, 18.24 -58.71, -66.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.28 0.2 0.247 B 313 280 15 0 0 15 [[535, 809]] 1.0 7xdy Arabidopsis thaliana TKL_FERONIA_ARATH TKL 2e-57 200.7 3 266 264 678 679 680 682 684 565 581 585 658 660 659 661 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
TKL FERONIA FERON_ARATH 7XDWA Q9SCZ4 521 815 895.0 ADP:901 ATPlike None DFGin 6.737 15.747 BLAminus -137.39, -174.63 58.35, 60.55 -84.66, 26.98 279.96, 82.38 -74.32, -25.62 in-none in 8.732 Saltbr-none 999.0 HRD-in -69.86, -44.55 71.98, 2.17 none-in-none SNCnin in-none ActLoopNT-in 2.918 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 144.08 APE8-rot-in 320.64 APE67-dihe-in -58.47, -9.87 -56.6, -62.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.926 0.188 0.207 A 313 281 14 0 0 14 [[535, 809]] 1.0 7xdw Arabidopsis thaliana TKL_FERONIA_ARATH TKL 8.2e-57 198.7 3 266 264 678 679 680 682 684 565 581 585 658 660 659 661 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
TKL FERONIA FERON_ARATH 7XDWB Q9SCZ4 522 816 895.0 ADP:901 ATPlike None DFGin 6.708 15.519 BLAminus -137.44, -171.65 65.06, 59.01 -87.27, 21.93 280.32, 83.86 -70.86, -24.01 in-none in 8.702 Saltbr-none 999.0 HRD-in -70.0, -44.65 71.38, 1.15 none-in-none SNCnin in-none ActLoopNT-in 2.944 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 146.34 APE8-rot-in 314.87 APE67-dihe-inflip 95.5, -19.53 -58.77, 130.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.926 0.188 0.207 B 313 281 14 0 0 14 [[535, 809]] 1.0 7xdw Arabidopsis thaliana TKL_FERONIA_ARATH TKL 8.2e-57 198.7 3 266 264 678 679 680 682 684 565 581 585 658 660 659 661 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
AGC GRK1 GRK1_BOVIN 3C4ZA P28327 31 533 561.0 ADP:562 ATPlike Active DFGin 5.913 13.235 BLAminus -149.46, 171.26 70.91, 78.39 -108.02, 16.47 270.55, 111.24 -69.43, -16.01 in-in in 8.736 Saltbr-in 2.716 HRD-in -71.08, -53.07 69.31, 6.53 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.53, 147.45 APE9-dihe-na 134.96, -165.72 APE8-dihe-in -111.39, 128.56 APE8-rot-in 296.58 APE67-dihe-inflip 96.79, -17.75 -54.96, 131.39 APE12-dist-in 10.43 APE11-dist-in 11.113 APE10-dist-in 5.49 APE9-dist-in 3.542 None None None XRAY 1.84 0.193 999.0 A 543 493 0 0 0 0 [[187, 452]] 1.0 3c4z Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C50A P28327 30 533 561.0 ADP:562 ATPlike Active DFGin 6.075 13.034 BLAminus -142.59, 172.43 68.85, 78.38 -104.12, 14.36 280.99, 104.76 -67.57, -15.07 in-in in 8.602 Saltbr-in 2.925 HRD-in -76.21, -52.36 64.46, 15.62 in-in-in SNCiii in-in ActLoopNT-in 2.795 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.66, 144.27 APE9-dihe-na 130.37, -165.26 APE8-dihe-in -104.68, 131.22 APE8-rot-in 300.48 APE67-dihe-inflip 92.29, -6.18 -56.88, 135.03 APE12-dist-in 10.685 APE11-dist-in 11.469 APE10-dist-in 5.876 APE9-dist-in 3.473 None None None XRAY 2.6 0.19 999.0 A 543 499 0 0 0 0 [[187, 452]] 1.0 3c50 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C50B P28327 30 533 561.0 ADP:562 ATPlike Active DFGin 6.078 13.068 BLAminus -140.52, 175.4 66.53, 77.05 -104.14, 18.55 279.39, 103.87 -67.23, -21.39 in-in in 8.532 Saltbr-in 2.721 HRD-in -71.74, -52.34 63.89, 11.32 in-in-in SNCiii in-in ActLoopNT-in 2.89 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.47, 143.37 APE9-dihe-na 137.53, -168.17 APE8-dihe-in -105.39, 125.32 APE8-rot-in 297.12 APE67-dihe-inflip 95.82, -17.57 -51.32, 135.4 APE12-dist-in 10.129 APE11-dist-in 11.115 APE10-dist-in 5.538 APE9-dist-in 3.418 None None None XRAY 2.6 0.19 999.0 B 543 496 0 0 0 0 [[187, 452]] 1.0 3c50 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C51A P28327 31 533 561.0 ADP:562 ATPlike Active DFGin 5.735 13.235 BLAminus -156.28, 178.74 57.85, 73.51 -84.14, -2.01 283.03, 106.57 -47.35, -22.99 in-in in 8.798 Saltbr-in 2.687 HRD-in -64.41, -45.82 69.5, -19.46 in-in-in SNCiii in-in ActLoopNT-in 2.916 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -176.64, 142.5 APE9-dihe-na 155.52, -169.52 APE8-dihe-in -101.5, 135.25 APE8-rot-in 300.99 APE67-dihe-inflip 84.91, 4.53 -59.96, 128.0 APE12-dist-in 10.573 APE11-dist-in 11.541 APE10-dist-in 6.152 APE9-dist-in 3.937 None None None XRAY 3.55 0.281 999.0 A 543 487 0 0 0 0 [[187, 452]] 1.0 3c51 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C51B P28327 31 533 561.0 ADP:562 ATPlike Active DFGin 5.785 13.187 BLAminus -156.29, 175.57 58.57, 74.43 -85.29, -1.69 285.99, 107.07 -47.38, -22.91 in-in in 8.696 Saltbr-in 2.792 HRD-in -66.67, -42.5 63.68, -15.39 in-in-in SNCiii in-in ActLoopNT-in 2.969 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -176.05, 141.93 APE9-dihe-na 155.26, -171.96 APE8-dihe-in -101.33, 138.35 APE8-rot-in 299.85 APE67-dihe-inflip 84.6, 5.24 -64.39, 128.67 APE12-dist-in 10.537 APE11-dist-in 11.598 APE10-dist-in 6.156 APE9-dist-in 3.94 None None None XRAY 3.55 0.281 999.0 B 543 461 20 0 0 0 [[187, 452]] 1.0 3c51 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3QC9A P28327 31 533 561.0 ADP:700 ATPlike Active DFGin 6.852 13.484 BLAminus -151.04, 174.48 70.22, 99.25 -129.57, 18.73 275.22, 99.19 -61.63, -18.96 in-in in 8.961 Saltbr-in 3.127 HRD-in -61.98, -58.15 73.37, -3.42 in-in-in SNCiii in-in ActLoopNT-in 2.917 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -167.32, 133.82 APE9-dihe-na 142.48, -169.15 APE8-dihe-in -104.33, 125.71 APE8-rot-in 302.67 APE67-dihe-inflip 104.42, -3.83 -50.74, 122.55 APE12-dist-in 10.356 APE11-dist-in 11.014 APE10-dist-in 5.5 APE9-dist-in 3.664 T8C,N480C None None XRAY 2.7 0.194 0.229 A 543 486 0 0 0 0 [[187, 452]] 1.0 3qc9 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3QC9B P28327 31 533 561.0 ADP:700 ATPlike Active DFGin 6.899 13.504 BLAminus -154.17, 173.67 70.5, 100.81 -132.54, 18.75 276.87, 97.69 -56.57, -24.02 in-in in 8.931 Saltbr-in 3.099 HRD-in -65.24, -58.34 73.4, -2.88 in-in-in SNCiii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -166.53, 132.45 APE9-dihe-na 145.72, -169.79 APE8-dihe-in -103.09, 126.5 APE8-rot-in 303.38 APE67-dihe-inflip 99.94, -4.73 -52.12, 123.93 APE12-dist-in 10.368 APE11-dist-in 11.038 APE10-dist-in 5.525 APE9-dist-in 3.677 T8C,N480C None None XRAY 2.7 0.194 0.229 B 543 481 0 0 0 0 [[187, 452]] 1.0 3qc9 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3QC9C P28327 31 533 561.0 ADP:700 ATPlike Active DFGin 6.868 13.481 BLAminus -151.87, 172.48 72.03, 98.62 -128.19, 19.72 276.34, 98.38 -59.47, -19.79 in-in in 8.951 Saltbr-in 3.107 HRD-in -62.09, -58.44 72.04, -1.68 in-in-in SNCiii in-in ActLoopNT-in 2.936 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -168.26, 134.05 APE9-dihe-na 142.83, -170.11 APE8-dihe-in -104.04, 126.58 APE8-rot-in 301.36 APE67-dihe-inflip 105.14, -2.81 -49.9, 120.73 APE12-dist-in 10.384 APE11-dist-in 11.018 APE10-dist-in 5.508 APE9-dist-in 3.673 T8C,N480C None None XRAY 2.7 0.194 0.229 C 543 482 0 0 0 0 [[187, 452]] 1.0 3qc9 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3QC9D P28327 31 533 561.0 ADP:700 ATPlike Active DFGin 6.923 13.517 BLAminus -151.29, 174.11 71.25, 99.27 -130.54, 20.81 276.77, 98.72 -58.99, -24.3 in-in in 8.931 Saltbr-in 3.091 HRD-in -63.44, -57.63 71.87, -0.43 in-in-in SNCiii in-in ActLoopNT-in 2.927 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.95, 134.69 APE9-dihe-na 141.2, -168.54 APE8-dihe-in -103.28, 126.55 APE8-rot-in 303.76 APE67-dihe-inflip 102.49, -2.5 -51.29, 121.62 APE12-dist-in 10.397 APE11-dist-in 11.044 APE10-dist-in 5.513 APE9-dist-in 3.693 T8C,N480C None None XRAY 2.7 0.194 0.229 D 543 486 0 0 0 0 [[187, 452]] 1.0 3qc9 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
CK1 HRR25 Q6FS46_CANGA 4XH0A Q6FS46 3 397 495.0 ADP:501 ATPlike None DFGin 6.443 15.383 BLAminus -128.64, -179.51 59.61, 77.98 -98.4, 10.06 283.06, 95.13 -55.51, -31.98 in-none in 8.149 Saltbr-none 999.0 HRD-in -77.95, -46.78 69.84, 1.34 none-in-in SNCnii in-in ActLoopNT-in 2.77 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.48, 125.7 APE9-dihe-na -118.27, -46.73 APE8-dihe-in -107.01, 112.94 APE8-rot-in 317.73 APE67-dihe-in -59.61, -42.11 -60.33, -32.21 APE12-dist-in 13.281 APE11-dist-in 12.522 APE10-dist-in 6.926 APE9-dist-in 5.2 K38R None None XRAY 1.99 0.168 0.2 A 403 350 5 0 0 0 [[9, 275]] 1.0 4xh0 Candida glabrata CK1_HRR25_CANGA CK1 2.6e-101 344.7 1 261 261 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 non-specific serine/threonine protein kinase
CK1 HRR25 Q6FS46_CANGA 4XHGA Q6FS46 2 397 495.0 ADP:501 ATPlike Inactive DFGin 6.768 15.524 BLAminus -126.45, -178.1 65.49, 74.25 -101.88, 16.36 285.39, 86.86 -58.89, -30.96 in-none in 8.237 Saltbr-none 999.0 HRD-in -77.78, -51.52 75.28, -1.16 none-in-out SNCnio in-out ActLoopNT-in 2.85 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -115.41, -44.98 APE9-dihe-na -99.02, -152.38 APE8-dihe-in -72.06, 134.26 APE8-rot-in 284.45 APE67-dihe-in -61.84, -37.14 -105.15, 28.83 APE12-dist-in 12.985 APE11-dist-in 12.438 APE10-dist-out 8.315 APE9-dist-out 8.181 K38R None None XRAY 2.15 0.176 0.216 A 403 357 0 0 0 0 [[9, 275]] 1.0 4xhg Candida glabrata CK1_HRR25_CANGA CK1 2.6e-101 344.7 1 261 261 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 non-specific serine/threonine protein kinase
AGC PRKACA KAPCA_CRIGR 6EM6A P25321 12 351 351.0 ADP:60401 ATPlike Inactive DFGin 6.859 14.821 BLAminus -128.32, 163.45 74.87, 92.52 -104.27, 28.45 286.23, 74.8 -62.75, -23.58 in-out in 9.704 Saltbr-out 4.362 HRD-in -85.36, -55.87 71.35, 12.71 out-in-in SNCoii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.91, 157.75 APE9-dihe-na 127.42, -164.4 APE8-dihe-in -115.9, 133.37 APE8-rot-in 304.12 APE67-dihe-in -57.32, -23.54 -48.16, -51.44 APE12-dist-in 8.046 APE11-dist-in 11.309 APE10-dist-in 5.737 APE9-dist-in 3.819 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.64 0.175 0.191 A 353 340 0 0 0 0 [[44, 298]] 1.0 6em6 Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6EM7A P25321 11 351 351.0 ADP:60403 ATPlike Active DFGin 5.924 14.338 BLAminus -118.71, 173.1 68.53, 85.06 -96.18, 23.36 270.78, 55.34 -59.75, -28.55 in-in in 8.741 Saltbr-in 2.711 HRD-in -88.33, -53.93 74.88, 10.19 in-in-in SNCiii in-in ActLoopNT-in 2.967 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.73, 159.92 APE9-dihe-na 127.98, -160.75 APE8-dihe-in -119.5, 137.47 APE8-rot-in 298.57 APE67-dihe-in -59.39, -22.73 -49.47, -50.59 APE12-dist-in 8.05 APE11-dist-in 11.429 APE10-dist-in 5.809 APE9-dist-in 3.674 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.238 0.139 0.157 A 353 341 0 0 0 0 [[44, 298]] 1.0 6em7 Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CMGC CDK Q5CRJ8_CRYPI 3NIZA Q5CRJ8 1 293 295.0 ADP:60314 ATPlike Inactive DFGin 6.414 14.921 BLAminus -148.14, 171.85 62.34, 76.33 -90.55, 26.42 283.17, 83.82 -64.08, -27.13 in-in in 9.199 Saltbr-in 3.051 HRD-in -69.04, -53.75 72.92, -5.13 in-in-out SNCiio in-out ActLoopNT-in 2.904 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -75.55, 106.41 APE9-dihe-na -120.78, 159.03 APE8-dihe-in -63.65, 138.42 APE8-rot-out 189.36 APE67-dihe-in -64.68, -19.03 -103.04, 13.52 APE12-dist-in 10.7 APE11-dist-in 9.767 APE10-dist-out 13.892 APE9-dist-out 9.548 None None None XRAY 2.4 0.223 0.256 A 311 284 9 0 0 3 [[5, 286]] 1.0 3niz Cryptosporidium parvum CMGC_CDK_CRYPI CMGC 1.9e-86 296.3 1 301 301 143 144 145 147 149 33 51 55 123 125 124 126 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 2 homolog
CAMK PLK1 Q4KMI8_DANRE 3D5WA Q4KMI8 24 310 595.0 ADP:313 ATPlike Inactive DFGin 5.84 15.103 BLAminus -136.31, -173.3 52.58, 90.43 -100.9, 29.72 290.61, 88.81 -67.31, -18.54 out-out out 10.538 Saltbr-out 4.57 HRD-in -72.81, -47.33 67.56, -5.93 out-in-in SNCoii in-in ActLoopNT-in 2.901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.0, 153.74 APE9-dihe-na 145.11, -167.91 APE8-dihe-in -110.25, 127.19 APE8-rot-in 299.86 APE67-dihe-in -70.02, -15.96 -37.98, -47.89 APE12-dist-in 8.251 APE11-dist-in 11.275 APE10-dist-in 5.646 APE9-dist-in 3.912 None TPO196 TPO196 XRAY 2.6 0.244 0.271 A 317 285 2 0 0 0 [[39, 291]] 1.0 3d5w Danio rerio CAMK_PLK1_DANRE CAMK 4.6e-77 264.7 1 256 256 179 180 181 183 185 68 87 91 159 161 160 162 219 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase PLK
OTHER POMK SG196_DANRE 5GZAA Q5U3W1 53 342 347.0 ADP:401,ZZ1:405 ATPlike,Allosteric Pseudo DFGin 5.357 13.174 None -145.49, -53.43 -88.36, 87.6 -105.44, 34.02 303.67, 0.43 -66.19, -35.84 none-na none 999.0 Saltbr-na 999.0 HRD-out -76.02, 100.34 -84.46, -37.81 na-in-out SNCaio in-out ActLoopNT-in 3.176 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iioo APE10-dihe-na -72.0, 131.22 APE9-dihe-na -98.58, 149.02 APE8-dihe-in -137.88, 170.05 APE8-rot-out 49.36 APE67-dihe-out -89.83, -15.07 100.95, 169.89 APE12-dist-in 12.164 APE11-dist-in 13.936 APE10-dist-out 17.359 APE9-dist-out 9.415 None None None XRAY 2.0 0.203 0.218 A 290 290 0 0 0 0 [[72, 335]] 1.0 5gza Danio rerio OTHER_POMK_DANRE POMK 3.3e-138 465.4 1 265 265 224 225 226 228 230 106 120 124 199 201 200 202 278 254 249 248 247 246 245 244 243 148 Protein O-mannose kinase
CAMK CAMKII KCC2A_DROME 5FG8A Q00168 7 275 530.0 ADP:301 ATPlike Active DFGin 5.883 14.23 BLAminus -120.35, -179.38 64.2, 77.37 -92.62, 22.59 287.14, 78.3 -59.18, -27.49 in-in in 8.996 Saltbr-in 2.798 HRD-in -79.26, -45.5 78.31, -3.25 in-in-in SNCiii in-in ActLoopNT-in 2.936 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.29, 153.59 APE9-dihe-na 138.39, -158.82 APE8-dihe-in -123.15, 126.57 APE8-rot-in 291.32 APE67-dihe-in -61.12, -15.42 -38.96, -61.46 APE12-dist-in 10.208 APE11-dist-in 11.816 APE10-dist-in 6.289 APE9-dist-in 3.479 None None None XRAY 1.955 0.192 0.221 A 285 269 0 0 0 0 [[14, 272]] 1.0 5fg8 Drosophila melanogaster CAMK_CAMKII_DROME CAMK 6.3e-98 333.1 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II alpha chain
CAMK CAMKII KCC2A_DROME 5HU3A Q00168 7 272 530.0 ADP:301 ATPlike Active DFGin 5.625 14.217 BLAminus -125.3, -175.54 57.54, 73.58 -90.7, 26.83 289.37, 84.29 -62.44, -29.23 in-in in 8.952 Saltbr-in 2.671 HRD-in -75.88, -45.31 74.57, -1.26 in-in-in SNCiii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.12, 157.18 APE9-dihe-na 139.99, -158.88 APE8-dihe-in -121.63, 130.83 APE8-rot-in 294.31 APE67-dihe-in -66.75, -12.95 -42.37, -59.45 APE12-dist-in 10.059 APE11-dist-in 11.766 APE10-dist-in 6.277 APE9-dist-in 3.564 D136N None None XRAY 1.885 0.194 0.228 A 285 266 0 0 0 0 [[14, 272]] 1.0 5hu3 Drosophila melanogaster CAMK_CAMKII_DROME CAMK 5.7e-97 329.9 1 256 256 156 157 158 160 162 43 61 65 133 135 134 136 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II alpha chain
CAMK OBSCN-1 OBSCN_DROME 8AK3A A8DYP0 3186 3477 4218.0 ADP:63501 ATPlike Pseudo DFGin 5.905 13.485 BLAminus -132.07, -172.8 60.67, 81.34 -101.92, 21.49 307.26, 110.13 -57.27, -33.59 in-in in 7.72 Saltbr-in 2.761 HRD-in -74.37, -46.4 81.73, -14.06 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -140.07, 151.0 APE9-dihe-na 162.46, 172.55 APE8-dihe-in -86.0, 119.15 APE8-rot-na 203.36 APE67-dihe-in -78.57, -5.95 -56.15, -31.0 APE12-dist-in 8.047 APE11-dist-in 10.008 APE10-dist-in 6.691 APE9-dist-in 5.787 None None None XRAY 1.9 0.175 0.208 A 297 292 0 0 0 0 [[3186, 3440], [3897, 4151]] 2.0 8ak3 Drosophila melanogaster CAMK_OBSCN-1_DROME CAMK 2.3e-61 213.3 1 256 256 3325 3326 3327 3329 3331 3215 3230 3234 3303 3305 3304 3306 3364 3352 3347 3346 3345 3344 3343 3342 3341 3260 Protein Obscurin
OTHER BUBR1 A1Z6I7_DROME 6JKMA A1Z6I7 1127 1459 1460.0 ADP:61501 ATPlike Inactive DFGin 6.009 13.948 BLAminus -128.73, 177.45 65.82, 73.45 -92.38, 26.0 302.65, 107.99 -57.62, -35.04 in-in in 8.333 Saltbr-in 2.987 HRD-in -63.93, -46.09 73.48, 2.84 in-in-out SNCiio in-out ActLoopNT-in 2.755 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooo APE10-dihe-na -54.34, 146.08 APE9-dihe-na -76.3, -56.25 APE8-dihe-in -62.83, 122.42 APE8-rot-na 191.74 APE67-dihe-in -57.79, -24.72 -57.87, -34.67 APE12-dist-in 12.122 APE11-dist-out 15.974 APE10-dist-out 12.426 APE9-dist-out 12.395 None None None XRAY 1.95 0.181 0.226 A 341 333 0 0 0 0 [[1175, 1438]] 1.0 6jkm Drosophila melanogaster OTHER_BUBR1_DROME BUB 7.6e-133 447.7 1 265 265 1325 1326 1327 1329 1331 1204 1213 1217 1298 1300 1299 1301 1367 1355 1350 1349 1348 1347 1346 1345 1344 1251 Bub1-related kinase
CAMK CDPK Q3HNM4_EIMTE 4YSJA Q3HNM4 26 499 505.0 ADP:60506 ATPlike Active DFGin 6.651 14.005 BLAminus -140.39, -165.72 52.75, 66.63 -84.34, 22.0 285.15, 82.54 -78.31, -16.63 in-in in 8.319 Saltbr-in 3.482 HRD-in -81.29, -53.0 84.02, -6.2 in-in-in SNCiii in-in ActLoopNT-in 2.898 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.58, 142.92 APE9-dihe-na 138.88, -163.22 APE8-dihe-in -136.98, 140.82 APE8-rot-in 303.29 APE67-dihe-in -62.88, -33.46 -45.59, -53.66 APE12-dist-in 9.144 APE11-dist-in 11.564 APE10-dist-in 5.99 APE9-dist-in 3.493 None None None XRAY 2.7 0.249 0.292 A 491 459 10 0 0 0 [[46, 303]] 1.0 4ysj Eimeria tenella CAMK_CDPK_EIMTE CAMK 6.1e-90 307.2 1 256 256 189 190 191 193 195 75 94 98 166 168 167 169 227 216 211 210 209 208 207 206 205 124 non-specific serine/threonine protein kinase
CAMK CDPK Q3HNM4_EIMTE 4YSJB Q3HNM4 26 499 505.0 ADP:60506 ATPlike Active DFGin 6.595 13.993 BLAminus -140.54, -165.92 54.1, 65.38 -84.49, 22.28 285.29, 82.38 -78.18, -16.85 in-in in 8.3 Saltbr-in 3.494 HRD-in -81.3, -52.72 84.55, -6.86 in-in-in SNCiii in-in ActLoopNT-in 2.869 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.46, 142.21 APE9-dihe-na 137.64, -162.65 APE8-dihe-in -138.56, 141.54 APE8-rot-in 303.24 APE67-dihe-in -62.83, -32.98 -44.74, -55.37 APE12-dist-in 8.901 APE11-dist-in 11.534 APE10-dist-in 5.979 APE9-dist-in 3.505 None None None XRAY 2.7 0.249 0.292 B 491 462 10 0 0 0 [[46, 303]] 1.0 4ysj Eimeria tenella CAMK_CDPK_EIMTE CAMK 6.1e-90 307.2 1 256 256 189 190 191 193 195 75 94 98 166 168 167 169 227 216 211 210 209 208 207 206 205 124 non-specific serine/threonine protein kinase
OTHER STT7 C1EBN1_MICCC 4IX4A C1EBN1 151 489 489.0 ADP:60601 none Inactive None 999.0 999.0 None -124.77, 172.55 68.64, 78.1 -90.38, 21.25 292.81, 157.07 -65.27, -19.84 none-na none 999.0 Saltbr-na 999.0 HRD-na-- -69.85, -47.17 71.62, 4.08 na-in-none SNCain in-none ActLoopNT-in 2.96 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.499 0.163 0.199 A 350 339 0 0 0 0 [[62, 488]] 1.0 4ix4 Micromonas commoda OTHER_STT7_MICCC CMGC 1.3e-08 61.8 104 156 81 337 338 339 341 343 0 0 0 315 317 316 318 0 0 0 0 0 0 0 0 0 0 Protein kinase domain-containing protein
OTHER STT7 C1EBN1_MICCC 4IX4B C1EBN1 151 489 489.0 ADP:60601 none Inactive None 999.0 999.0 None -124.06, 172.31 67.36, 81.18 -93.11, 18.85 292.92, 160.57 -65.85, -21.57 none-na none 999.0 Saltbr-na 999.0 HRD-na-- -69.18, -45.52 70.51, 2.0 na-in-none SNCain in-none ActLoopNT-in 2.953 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.499 0.163 0.199 B 350 339 0 0 0 0 [[62, 488]] 1.0 4ix4 Micromonas commoda OTHER_STT7_MICCC CMGC 1.3e-08 61.8 104 156 81 337 338 339 341 343 0 0 0 315 317 316 318 0 0 0 0 0 0 0 0 0 0 Protein kinase domain-containing protein
OTHER STT7 C1EBN1_MICCC 4IX6A C1EBN1 151 489 489.0 ADP:60601 none Inactive None 999.0 999.0 None -121.42, 171.38 68.63, 78.17 -88.85, 21.64 296.86, 161.4 -62.59, -24.51 none-na none 999.0 Saltbr-na 999.0 HRD-na-- -70.26, -46.59 73.56, 1.3 na-in-none SNCain in-none ActLoopNT-in 2.949 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.6 0.174 0.193 A 350 339 0 0 0 0 [[62, 488]] 1.0 4ix6 Micromonas commoda OTHER_STT7_MICCC CMGC 1.3e-08 61.8 104 156 81 337 338 339 341 343 0 0 0 315 317 316 318 0 0 0 0 0 0 0 0 0 0 Protein kinase domain-containing protein
OTHER STT7 C1EBN1_MICCC 4IX6B C1EBN1 151 489 489.0 ADP:60601 none Inactive None 999.0 999.0 None -120.88, 168.28 70.6, 77.38 -87.7, 20.1 294.13, 158.65 -62.82, -23.17 none-na none 999.0 Saltbr-na 999.0 HRD-na-- -69.85, -45.21 71.7, -0.13 na-in-none SNCain in-none ActLoopNT-in 2.967 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.6 0.174 0.193 B 350 339 0 0 0 0 [[62, 488]] 1.0 4ix6 Micromonas commoda OTHER_STT7_MICCC CMGC 1.3e-08 61.8 104 156 81 337 338 339 341 343 0 0 0 315 317 316 318 0 0 0 0 0 0 0 0 0 0 Protein kinase domain-containing protein
TKL RIPK A0A811MS43_9POAL 8HODA A0A811MS43 82 379 435.0 ADP:60401 ATPlike Inactive DFGin 5.833 13.373 BLBplus -121.78, 161.33 63.78, 18.48 -72.74, 142.38 54.34, 88.33 69.05, 9.41 out-out out 13.949 Saltbr-out 11.845 HRD-out -80.81, 162.08 -71.22, -39.02 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -63.8, 122.58 APE9-dihe-na 79.64, 3.1 APE8-dihe-in -72.72, 144.78 APE8-rot-out 54.39 APE67-dihe-out 108.47, -0.29 -117.76, 31.22 APE12-dist-out 17.577 APE11-dist-out 21.132 APE10-dist-out 20.091 APE9-dist-out 12.203 S262A,T263A None None XRAY 1.95 0.201 0.228 A 326 279 19 0 0 9 [[97, 377]] 1.0 8hod Miscanthus lutarioriparius TKL_RIPK_9POAL TKL 6.7e-60 208.9 4 266 263 245 246 247 249 251 133 149 153 225 227 226 228 287 275 270 269 268 267 266 265 264 179 non-specific serine/threonine protein kinase
AGC PRKACA KAPCA_MOUSE 4NTTB P05132 11 351 351.0 ADP:60401 ATPlike Inactive DFGin 6.542 14.88 ABAminus -93.85, -35.44 -119.41, 118.31 -113.9, 43.83 296.85, 78.9 -65.87, -49.34 in-none in 9.869 Saltbr-none 999.0 HRD-in -94.05, -37.34 60.44, 1.66 none-in-in SNCnii in-in ActLoopNT-in 2.787 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -166.4, 146.42 APE9-dihe-na 126.7, -158.4 APE8-dihe-in -116.99, 137.33 APE8-rot-in 273.8 APE67-dihe-in -64.02, -34.69 -52.94, -43.07 APE12-dist-in 7.713 APE11-dist-in 10.72 APE10-dist-in 5.298 APE9-dist-in 4.164 K8C TPO198,SEP339 TPO198,SEP339 XRAY 3.5 0.23 0.284 B 350 341 0 0 0 0 [[44, 298]] 1.0 4ntt Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4O21A P05132 16 351 351.0 ADP:60401 ATPlike Active DFGin 6.037 14.439 BLAminus -125.27, 173.53 70.53, 83.75 -96.26, 25.58 272.04, 54.28 -57.91, -27.19 in-in in 8.953 Saltbr-in 2.716 HRD-in -83.95, -57.84 75.15, 8.54 in-in-in SNCiii in-in ActLoopNT-in 2.904 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.15, 164.3 APE9-dihe-na 125.14, -151.92 APE8-dihe-in -125.51, 129.66 APE8-rot-in 308.07 APE67-dihe-in -63.53, -19.17 -43.91, -48.76 APE12-dist-in 8.04 APE11-dist-in 11.46 APE10-dist-in 5.911 APE9-dist-in 3.451 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.95 0.17 0.215 A 342 336 0 0 0 0 [[44, 298]] 1.0 4o21 Mus musculus AGC_PRKACA_MOUSE AGC 1.4e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 1L3RE P05132 2 351 351.0 ADP:60381 ATPlike Active DFGin 5.754 14.44 BLAminus -119.14, -174.46 57.18, 81.19 -93.77, 20.31 270.88, 52.04 -50.0, -37.57 in-in in 9.023 Saltbr-in 2.792 HRD-in -82.45, -54.36 70.16, 7.26 in-in-in SNCiii in-in ActLoopNT-in 2.92 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.84, 161.06 APE9-dihe-na 132.7, -149.01 APE8-dihe-in -131.06, 132.91 APE8-rot-in 298.56 APE67-dihe-in -55.27, -27.25 -33.24, -62.94 APE12-dist-in 8.198 APE11-dist-in 11.233 APE10-dist-in 5.825 APE9-dist-in 3.368 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 2.0 0.205 0.232 E 350 341 0 0 0 0 [[44, 298]] 1.0 1l3r Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DH5A P05132 16 351 351.0 ADP:60403 ATPlike Active DFGin 6.121 14.339 BLAminus -125.12, -179.76 61.4, 85.13 -97.61, 27.77 279.05, 62.21 -46.99, -44.52 in-in in 9.043 Saltbr-in 2.552 HRD-in -77.92, -53.51 67.68, 1.05 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.88, 153.17 APE9-dihe-na 132.88, -161.89 APE8-dihe-in -112.07, 131.8 APE8-rot-in 304.21 APE67-dihe-in -57.01, -23.17 -41.47, -55.69 APE12-dist-in 8.219 APE11-dist-in 11.602 APE10-dist-in 6.071 APE9-dist-in 3.87 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.2 0.187 0.222 A 350 336 0 0 0 0 [[44, 298]] 1.0 4dh5 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 5JR7A P05132 14 351 351.0 ADP:60400 ATPlike Active DFGin 5.739 13.691 BLAminus -145.14, 176.28 64.37, 76.68 -85.75, 18.89 294.14, 59.99 -43.66, -41.86 in-in in 8.674 Saltbr-in 2.709 HRD-in -93.38, -54.67 74.91, 7.39 in-in-in SNCiii in-in ActLoopNT-in 2.945 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.46, 148.2 APE9-dihe-na 147.95, -159.28 APE8-dihe-in -109.66, 131.32 APE8-rot-in 258.88 APE67-dihe-in -65.5, -25.8 -38.64, -53.47 APE12-dist-in 8.014 APE11-dist-in 10.772 APE10-dist-in 5.528 APE9-dist-in 3.878 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.56 0.269 0.322 A 350 338 0 0 0 0 [[44, 298]] 1.0 5jr7 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 5JR7C P05132 14 351 351.0 ADP:60400 ATPlike Active DFGin 5.899 13.164 BLAminus -138.79, 176.44 54.89, 86.07 -89.1, 7.67 290.95, 62.79 -41.83, -37.01 in-in in 8.185 Saltbr-in 3.195 HRD-in -79.11, -50.37 72.48, -21.93 in-in-in SNCiii in-in ActLoopNT-in 2.819 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.28, 123.46 APE9-dihe-na 160.31, -160.86 APE8-dihe-in -110.49, 124.04 APE8-rot-in 311.35 APE67-dihe-in -70.47, -24.34 -45.9, -42.95 APE12-dist-in 8.163 APE11-dist-in 10.628 APE10-dist-in 5.002 APE9-dist-in 4.262 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.56 0.269 0.322 C 350 338 0 0 0 0 [[44, 298]] 1.0 5jr7 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 7UJXE P05132 16 351 351.0 ADP:60401 ATPlike Active DFGin 5.731 14.357 BLAminus -121.93, 179.51 64.92, 83.56 -91.91, 29.5 277.22, 63.03 -64.62, -28.12 in-in in 9.103 Saltbr-in 2.812 HRD-in -86.19, -57.72 74.11, 16.74 in-in-in SNCiii in-in ActLoopNT-in 2.931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.48, 155.47 APE9-dihe-na 127.23, -161.98 APE8-dihe-in -111.77, 133.52 APE8-rot-in 302.04 APE67-dihe-in -65.07, -18.97 -50.87, -44.77 APE12-dist-in 8.191 APE11-dist-in 11.5 APE10-dist-in 5.961 APE9-dist-in 4.008 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.4 0.133 0.176 E 350 336 0 0 0 0 [[44, 298]] 1.0 7ujx Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 7V0GE P05132 17 351 351.0 ADP:60401 ATPlike Active DFGin 5.739 14.319 BLAminus -119.5, 177.58 67.43, 82.74 -91.45, 25.21 276.8, 64.92 -62.46, -26.34 in-in in 9.07 Saltbr-in 2.802 HRD-in -88.93, -50.41 71.3, 15.33 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.52, 156.77 APE9-dihe-na 130.04, -162.37 APE8-dihe-in -114.97, 131.2 APE8-rot-in 299.52 APE67-dihe-in -60.0, -22.75 -47.18, -49.61 APE12-dist-in 8.174 APE11-dist-in 11.542 APE10-dist-in 6.037 APE9-dist-in 3.965 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.63 0.118 0.163 E 350 335 0 0 0 0 [[44, 298]] 1.0 7v0g Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IADA P05132 15 351 351.0 ADP:60403 ATPlike Active DFGin 5.658 14.362 BLAminus -130.04, -179.13 63.0, 77.66 -87.34, 22.78 276.11, 53.54 -55.12, -31.28 in-in in 9.085 Saltbr-in 2.83 HRD-in -93.22, -52.19 70.15, 14.14 in-in-in SNCiii in-in ActLoopNT-in 2.935 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.54, 160.6 APE9-dihe-na 133.65, -143.98 APE8-dihe-in -130.05, 134.5 APE8-rot-in 298.49 APE67-dihe-in -67.08, -22.74 -48.94, -44.54 APE12-dist-in 8.051 APE11-dist-in 11.55 APE10-dist-in 6.087 APE9-dist-in 3.521 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.9 0.189 0.243 A 356 337 0 0 0 0 [[44, 298]] 1.0 4iad Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IAFA P05132 16 351 351.0 ADP:60403 ATPlike Active DFGin 5.943 14.13 BLAminus -121.29, 178.82 64.06, 84.8 -98.0, 27.2 281.56, 65.38 -51.93, -33.25 in-in in 8.871 Saltbr-in 2.669 HRD-in -76.48, -53.65 65.3, 9.94 in-in-in SNCiii in-in ActLoopNT-in 2.974 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.4, 160.11 APE9-dihe-na 128.66, -151.44 APE8-dihe-in -123.86, 135.06 APE8-rot-in 298.27 APE67-dihe-in -57.84, -25.84 -42.55, -55.44 APE12-dist-in 8.163 APE11-dist-in 11.523 APE10-dist-in 5.973 APE9-dist-in 3.563 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.2 0.16 0.192 A 356 336 0 0 0 0 [[44, 298]] 1.0 4iaf Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IAIA P05132 16 351 351.0 ADP:60403 ATPlike Active DFGin 5.465 14.503 BLAminus -125.1, 176.4 64.24, 81.88 -90.74, 22.64 269.91, 49.4 -55.45, -35.99 in-in in 9.101 Saltbr-in 2.714 HRD-in -91.06, -49.32 68.79, 15.16 in-in-in SNCiii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.75, 156.86 APE9-dihe-na 141.29, -148.36 APE8-dihe-in -128.24, 130.8 APE8-rot-in 300.02 APE67-dihe-in -62.27, -23.0 -47.39, -47.75 APE12-dist-in 7.945 APE11-dist-in 11.458 APE10-dist-in 5.867 APE9-dist-in 3.608 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.55 0.171 0.209 A 356 336 0 0 0 0 [[44, 298]] 1.0 4iai Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IAKA P05132 15 351 351.0 ADP:60403 ATPlike Active DFGin 5.705 14.569 BLAminus -126.92, 179.61 63.08, 81.74 -90.27, 23.65 270.26, 53.44 -59.05, -31.45 in-in in 8.985 Saltbr-in 2.747 HRD-in -94.54, -49.89 67.85, 16.15 in-in-in SNCiii in-in ActLoopNT-in 2.91 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.92, 164.74 APE9-dihe-na 131.87, -148.57 APE8-dihe-in -130.85, 127.67 APE8-rot-in 297.68 APE67-dihe-in -61.28, -21.91 -43.91, -50.7 APE12-dist-in 7.962 APE11-dist-in 11.443 APE10-dist-in 5.979 APE9-dist-in 3.545 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.6 0.185 0.222 A 356 337 0 0 0 0 [[44, 298]] 1.0 4iak Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IAYA P05132 16 351 351.0 ADP:60403 ATPlike Active DFGin 5.806 14.257 BLAminus -131.74, 174.05 67.76, 85.89 -95.28, 20.31 273.12, 61.73 -48.17, -36.05 in-in in 9.039 Saltbr-in 2.941 HRD-in -89.87, -50.65 68.98, 10.01 in-in-in SNCiii in-in ActLoopNT-in 3.055 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.39, 159.46 APE9-dihe-na 132.54, -148.24 APE8-dihe-in -127.91, 130.95 APE8-rot-in 300.76 APE67-dihe-in -63.09, -19.35 -45.58, -49.88 APE12-dist-in 8.089 APE11-dist-in 11.466 APE10-dist-in 5.991 APE9-dist-in 3.823 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.0 0.182 0.227 A 356 336 0 0 0 0 [[44, 298]] 1.0 4iay Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IAZA P05132 15 351 351.0 ADP:60403 ATPlike Active DFGin 6.144 14.635 BLAminus -132.33, 171.23 62.84, 84.78 -94.94, 21.85 278.49, 61.31 -54.74, -28.93 in-in in 9.219 Saltbr-in 2.747 HRD-in -95.03, -54.93 73.76, 14.73 in-in-in SNCiii in-in ActLoopNT-in 3.017 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.57, 164.74 APE9-dihe-na 127.12, -150.82 APE8-dihe-in -127.02, 138.46 APE8-rot-in 303.51 APE67-dihe-in -63.11, -25.72 -51.71, -47.83 APE12-dist-in 7.963 APE11-dist-in 11.514 APE10-dist-in 5.979 APE9-dist-in 3.574 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.85 0.201 0.248 A 356 337 0 0 0 0 [[44, 298]] 1.0 4iaz Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IB0A P05132 15 351 351.0 ADP:60403 ATPlike Active DFGin 5.713 14.439 BLAminus -123.68, 176.86 65.62, 82.22 -94.42, 18.76 272.15, 51.12 -47.84, -35.86 in-in in 9.065 Saltbr-in 3.023 HRD-in -84.67, -55.05 71.31, 12.11 in-in-in SNCiii in-in ActLoopNT-in 2.886 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.67, 157.49 APE9-dihe-na 139.08, -144.95 APE8-dihe-in -131.16, 131.55 APE8-rot-in 306.17 APE67-dihe-in -61.31, -24.54 -46.0, -48.78 APE12-dist-in 8.059 APE11-dist-in 11.516 APE10-dist-in 5.969 APE9-dist-in 3.692 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.87 0.219 0.287 A 356 337 0 0 0 0 [[44, 298]] 1.0 4ib0 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IB1A P05132 14 351 351.0 ADP:60403 ATPlike Active DFGin 5.656 14.443 BLAminus -126.58, 171.72 66.62, 80.69 -90.79, 23.58 274.18, 53.88 -53.03, -31.34 in-in in 9.121 Saltbr-in 2.691 HRD-in -82.93, -51.49 69.93, 14.85 in-in-in SNCiii in-in ActLoopNT-in 2.98 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.64, 163.58 APE9-dihe-na 133.1, -151.37 APE8-dihe-in -125.38, 138.08 APE8-rot-in 304.1 APE67-dihe-in -60.15, -23.69 -50.01, -49.7 APE12-dist-in 7.96 APE11-dist-in 11.404 APE10-dist-in 5.961 APE9-dist-in 3.635 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.63 0.196 0.223 A 356 338 0 0 0 0 [[44, 298]] 1.0 4ib1 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IB3A P05132 13 351 351.0 ADP:60401 ATPlike Active DFGin 5.973 14.215 BLAminus -125.69, 173.12 66.37, 84.97 -98.59, 21.41 276.57, 60.51 -51.27, -29.52 in-in in 8.99 Saltbr-in 2.76 HRD-in -77.27, -49.79 61.58, 13.48 in-in-in SNCiii in-in ActLoopNT-in 2.869 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.06, 160.46 APE9-dihe-na 127.6, -161.57 APE8-dihe-in -110.98, 129.89 APE8-rot-in 305.68 APE67-dihe-in -58.89, -23.07 -39.61, -54.94 APE12-dist-in 8.078 APE11-dist-in 11.522 APE10-dist-in 5.923 APE9-dist-in 3.568 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.2 0.182 0.228 A 356 339 0 0 0 0 [[44, 298]] 1.0 4ib3 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4XW6A P05132 15 351 351.0 ADP:60403 ATPlike Active DFGin 5.982 14.431 BLAminus -130.68, 178.48 65.03, 84.15 -99.24, 23.41 276.01, 56.03 -60.45, -23.49 in-in in 9.15 Saltbr-in 2.735 HRD-in -94.59, -52.61 68.2, 15.9 in-in-in SNCiii in-in ActLoopNT-in 2.791 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.91, 154.59 APE9-dihe-na 136.7, -154.91 APE8-dihe-in -121.39, 127.95 APE8-rot-in 293.9 APE67-dihe-in -62.75, -24.38 -45.59, -46.76 APE12-dist-in 8.051 APE11-dist-in 11.632 APE10-dist-in 6.051 APE9-dist-in 3.787 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.9 0.186 0.265 A 356 337 0 0 0 0 [[44, 298]] 1.0 4xw6 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 6E21A P05132 16 351 351.0 ADP:60403 ATPlike Active DFGin 5.594 14.055 BLAminus -122.61, 176.37 63.02, 83.41 -94.2, 28.27 284.3, 46.09 -48.88, -41.13 in-in in 9.029 Saltbr-in 2.607 HRD-in -74.35, -56.8 67.48, 11.51 in-in-in SNCiii in-in ActLoopNT-in 2.907 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.7, 159.01 APE9-dihe-na 131.41, -152.84 APE8-dihe-in -125.29, 130.56 APE8-rot-in 303.23 APE67-dihe-in -58.42, -25.04 -35.36, -60.06 APE12-dist-in 8.043 APE11-dist-in 11.584 APE10-dist-in 6.022 APE9-dist-in 3.58 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.0 0.187 0.217 A 356 336 0 0 0 0 [[44, 298]] 1.0 6e21 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 1JBPE P05132 10 351 351.0 ADP:60381 ATPlike Inactive DFGin 6.128 14.034 BLAminus -131.98, 178.81 60.97, 83.81 -101.93, 15.49 276.81, 71.17 -55.35, -24.18 in-in in 8.869 Saltbr-in 2.749 HRD-out -93.99, 130.53 -128.02, 39.83 in-in-in SNCiii in-in ActLoopNT-in 2.886 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.07, 156.95 APE9-dihe-na 132.9, -168.64 APE8-dihe-in -109.4, 126.7 APE8-rot-in 297.85 APE67-dihe-in -61.28, -20.5 -33.82, -53.02 APE12-dist-in 8.121 APE11-dist-in 11.448 APE10-dist-in 6.013 APE9-dist-in 3.862 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.2 0.175 999.0 E 350 342 0 0 0 0 [[44, 298]] 1.0 1jbp Mus musculus AGC_PRKACA_MOUSE AGC 1.6e-94 321.9 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 1RDQE P05132 2 351 351.0 ADP:60599,ATP:60600 ATPlike,ATPlike Active DFGin 5.707 14.515 BLAminus -117.27, 178.71 64.74, 81.19 -90.07, 21.82 270.96, 52.48 -58.25, -31.62 in-in in 9.091 Saltbr-in 2.719 HRD-in -91.16, -53.36 73.19, 12.39 in-in-in SNCiii in-in ActLoopNT-in 2.936 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.91, 159.57 APE9-dihe-na 132.64, -151.85 APE8-dihe-in -127.7, 133.09 APE8-rot-in 298.45 APE67-dihe-in -59.33, -27.24 -47.42, -47.34 APE12-dist-in 8.116 APE11-dist-in 11.414 APE10-dist-in 5.831 APE9-dist-in 3.521 Y205A TPO198,SEP339 TPO198,SEP339 XRAY 1.26 0.132 0.162 E 350 342 0 0 0 0 [[44, 298]] 1.0 1rdq Mus musculus AGC_PRKACA_MOUSE AGC 1.1e-92 315.9 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4NTTA P05132 11 351 351.0 ADP:60401 ATPlike Inactive DFGin 6.255 15.221 None 58.0, -132.96 -135.23, 163.83 -122.73, 17.77 281.43, 74.72 -41.46, -50.2 in-out in 9.982 Saltbr-out 4.194 HRD-in -65.11, -40.77 60.9, 3.38 out-in-in SNCoii in-in ActLoopNT-in 2.864 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.9, 118.31 APE9-dihe-na 164.12, -173.28 APE8-dihe-in -108.19, 123.7 APE8-rot-in 267.93 APE67-dihe-in -75.4, -22.82 -40.35, -37.34 APE12-dist-in 8.188 APE11-dist-in 11.159 APE10-dist-in 5.542 APE9-dist-in 4.321 None TPO198,SEP339 TPO198,SEP339 XRAY 3.5 0.23 0.284 A 350 341 0 0 0 0 [[44, 298]] 1.0 4ntt Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CAMK CAMK2A KCC2A_MOUSE 7B57B P11798 5 307 478.0 ADP:603 ATPlike Active DFGin 6.612 14.081 BLAminus -127.42, 175.73 58.47, 86.34 -93.82, 26.41 288.57, 77.62 -63.18, -29.51 in-in in 8.79 Saltbr-in 2.799 HRD-in -66.41, -49.66 65.98, 1.57 in-in-in SNCiii in-in ActLoopNT-in 2.933 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.13, 142.7 APE9-dihe-na 131.67, 177.43 APE8-dihe-in -91.43, 131.98 APE8-rot-in 302.75 APE67-dihe-in -62.31, -16.39 -48.04, -47.99 APE12-dist-in 10.368 APE11-dist-in 11.44 APE10-dist-in 5.743 APE9-dist-in 3.998 T305A,T306A None None XRAY 1.95 0.206 0.247 B 317 303 0 0 0 0 [[13, 271]] 1.0 7b57 Mus musculus CAMK_CAMK2A_MOUSE CAMK 1.7e-96 328.6 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CK1 CSNK1D KC1D_MOUSE 5X17A Q9DC28 3 292 415.0 ADP:307 Type1.5_Back Active DFGin 5.885 15.017 BLAminus -136.76, 176.51 70.17, 78.89 -96.78, 24.57 288.71, 93.09 -76.8, -15.99 in-in in 8.102 Saltbr-in 3.148 HRD-in -73.34, -55.18 81.19, 1.41 in-in-in SNCiii in-in ActLoopNT-in 2.824 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -69.47, -59.72 APE9-dihe-na -86.86, -154.47 APE8-dihe-in -76.87, 120.04 APE8-rot-in 308.55 APE67-dihe-in -51.63, -37.36 -55.73, -38.13 APE12-dist-in 10.457 APE11-dist-in 12.417 APE10-dist-in 6.378 APE9-dist-in 3.807 None None None XRAY 2.0 0.19 0.242 A 296 290 0 0 0 0 [[9, 275]] 1.0 5x17 Mus musculus CK1_CSNK1D_MOUSE CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_MOUSE 5X17B Q9DC28 4 292 415.0 ADP:306 Type1.5_Back Active DFGin 6.333 14.989 BLAminus -121.28, -179.96 69.25, 82.44 -101.59, 21.98 290.59, 89.01 -77.86, -17.5 in-in in 8.042 Saltbr-in 3.107 HRD-in -90.58, -48.35 72.79, 12.65 in-in-in SNCiii in-in ActLoopNT-in 2.76 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.44, 137.77 APE9-dihe-na 91.26, -171.32 APE8-dihe-in -91.08, 137.89 APE8-rot-in 301.79 APE67-dihe-in -58.2, -31.0 -69.62, -39.78 APE12-dist-in 12.297 APE11-dist-in 11.987 APE10-dist-in 6.492 APE9-dist-in 3.373 None None None XRAY 2.0 0.19 0.242 B 296 289 0 0 0 0 [[9, 275]] 1.0 5x17 Mus musculus CK1_CSNK1D_MOUSE CK1 1.6e-122 413.9 1 262 262 148 149 150 152 154 38 52 56 125 127 126 128 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CMGC GSK3B GSK3B_MOUSE 8VMFA Q9WV60 27 383 420.0 ADP:60504 ATPlike Active DFGin 6.612 14.1 BLAminus -148.4, -167.57 58.53, 66.72 -90.57, 24.21 287.49, 78.37 -75.04, -7.89 in-in in 8.66 Saltbr-in 2.678 HRD-in -67.34, -47.3 70.6, 6.45 in-in-in SNCiii in-in ActLoopNT-in 2.84 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -98.01, -20.74 APE9-dihe-na -93.16, -168.14 APE8-dihe-in -112.8, 164.36 APE8-rot-in 304.6 APE67-dihe-inflip 78.98, -8.38 -56.8, 140.56 APE12-dist-in 13.183 APE11-dist-in 10.949 APE10-dist-in 6.514 APE9-dist-in 3.308 None None None XRAY 2.5 0.21 0.251 A 364 354 0 0 0 0 [[56, 340]] 1.0 8vmf Mus musculus CMGC_GSK3B_MOUSE CMGC 2e-70 243.5 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_MOUSE 8VMGA Q9WV60 26 383 420.0 ADP:60401 ATPlike Active DFGin 7.0 13.999 BLAminus -139.67, -176.86 60.44, 73.06 -89.27, 27.07 283.1, 81.19 -73.23, -12.63 in-in in 8.478 Saltbr-in 2.688 HRD-in -67.64, -48.38 72.75, 3.36 in-in-in SNCiii in-in ActLoopNT-in 2.844 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.26, 164.63 APE9-dihe-na 72.45, 142.8 APE8-dihe-in -66.41, 146.08 APE8-rot-in 307.07 APE67-dihe-in -64.3, -22.81 -57.43, -46.54 APE12-dist-in 13.278 APE11-dist-in 11.627 APE10-dist-in 6.941 APE9-dist-in 2.984 None None None XRAY 2.45 0.195 0.23 A 364 358 0 0 0 0 [[56, 340]] 1.0 8vmg Mus musculus CMGC_GSK3B_MOUSE CMGC 2e-70 243.5 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_MOUSE 8VMEA Q9WV60 26 383 420.0 ADP:60401 ATPlike Active DFGin 6.469 13.844 BLAminus -131.0, -171.33 63.41, 73.0 -92.56, 22.88 289.27, 83.61 -79.03, -1.02 in-in in 8.753 Saltbr-in 2.78 HRD-in -67.9, -47.67 70.4, 7.52 in-in-in SNCiii in-in ActLoopNT-in 2.731 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.18, 168.01 APE9-dihe-na 68.83, 161.19 APE8-dihe-in -90.7, 152.54 APE8-rot-in 290.93 APE67-dihe-inflip 82.32, -22.26 -51.38, 150.9 APE12-dist-in 13.288 APE11-dist-in 12.071 APE10-dist-in 6.934 APE9-dist-in 3.292 None None None XRAY 2.3 0.183 0.23 A 365 355 0 0 0 0 [[56, 340]] 1.0 8vme Mus musculus CMGC_GSK3B_MOUSE CMGC 2.1e-70 243.5 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_MOUSE 4NU1A Q9WV60 6 383 420.0 ADP:405 ATPlike Active DFGin 6.109 13.677 BLAminus -140.27, -172.8 60.29, 88.19 -108.14, 24.39 289.57, 88.21 -68.01, -14.99 in-in in 8.691 Saltbr-in 2.793 HRD-in -66.76, -45.51 62.96, 19.85 in-in-in SNCiii in-in ActLoopNT-in 2.682 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.38, 172.68 APE9-dihe-na 66.76, 153.81 APE8-dihe-in -82.08, 156.46 APE8-rot-in 299.93 APE67-dihe-inflip 76.53, -25.22 -54.39, 158.45 APE12-dist-in 13.51 APE11-dist-in 11.621 APE10-dist-in 7.126 APE9-dist-in 3.15 None SEP9 SEP9 XRAY 2.5 0.194 0.245 A 389 357 2 0 0 0 [[56, 340]] 1.0 4nu1 Mus musculus CMGC_GSK3B_MOUSE CMGC 2.5e-70 243.2 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
OTHER ERN1 ERN1_MOUSE 4PL4B Q9EQY0 562 963 977.0 ADP:1001 ATPlike Inactive DFGin 7.393 13.497 BLBplus -131.17, -171.5 49.73, 22.15 -77.96, 172.77 53.0, 89.01 68.36, -18.97 out-out out 16.186 Saltbr-out 12.867 HRD-in -71.43, -56.11 80.63, -15.27 out-out-out SNCooo out-out ActLoopNT-out 10.3 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -71.5, 161.7 APE9-dihe-na 95.56, 170.85 APE8-dihe-in -126.15, 140.57 APE8-rot-in 313.23 APE67-dihe-inflip 115.41, -9.81 -59.18, 119.64 APE12-dist-none 999.0 APE11-dist-in 13.373 APE10-dist-out 8.963 APE9-dist-in 3.302 N772Y None None XRAY 3.0 0.213 0.276 B 435 384 18 0 0 12 [[571, 832]] 1.0 4pl4 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL4C Q9EQY0 562 963 977.0 ADP:1001 ATPlike Inactive DFGin 7.548 14.248 BLBplus -126.51, -173.84 57.1, 11.03 -79.33, 148.55 56.35, 128.67 90.22, -11.73 out-out out 16.972 Saltbr-out 13.449 HRD-in -87.09, -33.21 64.61, -28.11 out-out-out SNCooo out-out ActLoopNT-out 10.668 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioi APE10-dihe-na -75.07, 168.04 APE9-dihe-na 83.31, 160.45 APE8-dihe-in -117.06, 150.3 APE8-rot-out 84.63 APE67-dihe-inflip 114.33, -11.46 -59.41, 124.52 APE12-dist-none 999.0 APE11-dist-in 13.484 APE10-dist-out 8.449 APE9-dist-in 3.554 N772Y None None XRAY 3.0 0.213 0.276 C 435 384 18 0 0 12 [[571, 832]] 1.0 4pl4 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL4D Q9EQY0 562 961 977.0 ADP:1001 ATPlike Inactive DFGin 7.508 13.71 BLBplus -135.47, -173.14 51.5, 21.77 -87.04, 144.38 56.66, 114.14 91.93, -17.13 out-out out 15.979 Saltbr-out 13.34 HRD-in -83.86, -32.09 72.35, -48.88 out-out-out SNCooo out-out ActLoopNT-out 10.328 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -70.73, 154.49 APE9-dihe-na 96.39, -168.63 APE8-dihe-in -140.56, 130.56 APE8-rot-in 311.25 APE67-dihe-inflip 116.72, -15.16 -51.06, 117.77 APE12-dist-none 999.0 APE11-dist-in 13.97 APE10-dist-out 9.138 APE9-dist-in 3.922 N772Y None None XRAY 3.0 0.213 0.276 D 435 377 18 0 0 12 [[571, 832]] 1.0 4pl4 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL5B Q9EQY0 562 963 977.0 ADP:1001 ATPlike Inactive DFGin 7.455 13.937 BLBplus -129.37, -173.23 56.7, 18.18 -83.15, 166.18 46.51, 88.1 78.73, -17.65 out-out out 17.378 Saltbr-out 14.051 HRD-in -57.7, -43.88 69.49, -15.96 out-out-out SNCooo out-out ActLoopNT-out 10.048 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nioi APE10-dihe-na -68.77, 169.09 APE9-dihe-na 94.26, -167.14 APE8-dihe-in -147.72, 134.59 APE8-rot-in 292.91 APE67-dihe-out 142.49, -27.58 -41.24, 92.94 APE12-dist-none 999.0 APE11-dist-in 13.292 APE10-dist-out 8.446 APE9-dist-in 3.356 N772Y None None XRAY 3.4 0.225 0.285 B 435 383 19 0 0 13 [[571, 832]] 1.0 4pl5 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL5C Q9EQY0 562 963 977.0 ADP:1001 ATPlike Inactive DFGin 7.794 14.061 BLBplus -140.3, -178.86 59.78, 31.79 -102.25, 171.48 50.28, 80.31 73.36, 0.55 out-out out 16.852 Saltbr-out 12.634 HRD-in -71.26, -29.05 67.43, -40.0 out-out-out SNCooo out-out ActLoopNT-out 10.543 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -68.61, -176.62 APE9-dihe-na 79.33, -164.24 APE8-dihe-in -141.99, 145.59 APE8-rot-in 309.7 APE67-dihe-inflip 125.8, -7.43 -55.77, 102.3 APE12-dist-none 999.0 APE11-dist-in 13.684 APE10-dist-out 8.599 APE9-dist-in 3.649 N772Y None None XRAY 3.4 0.225 0.285 C 435 386 16 0 0 11 [[571, 832]] 1.0 4pl5 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL5D Q9EQY0 561 963 977.0 ADP:1001 ATPlike Inactive DFGin 6.883 13.709 BLBplus -149.88, 177.73 60.77, 34.53 -99.83, 170.66 50.74, 82.52 85.0, -30.32 out-out out 16.873 Saltbr-out 16.31 HRD-in -73.87, -31.52 63.42, -30.41 out-out-out SNCooo out-out ActLoopNT-out 10.862 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioi APE10-dihe-na -64.48, 167.99 APE9-dihe-na 99.63, 173.49 APE8-dihe-in -124.29, 140.67 APE8-rot-out 174.47 APE67-dihe-inflip 122.64, -17.06 -61.26, 114.95 APE12-dist-none 999.0 APE11-dist-in 13.232 APE10-dist-out 8.112 APE9-dist-in 3.919 N772Y None None XRAY 3.4 0.225 0.285 D 435 385 18 0 0 12 [[571, 832]] 1.0 4pl5 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL3A Q9EQY0 560 964 977.0 31J:1001,ADP:1002 Allosteric,ATPlike Inactive DFGin 7.327 13.716 BLBplus -137.83, -169.53 45.26, 38.38 -99.01, 160.39 56.61, 78.79 64.67, 4.33 out-out out 16.579 Saltbr-out 12.448 HRD-in -67.88, -49.57 75.5, 1.96 out-out-out SNCooo out-out ActLoopNT-out 9.693 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -56.59, -179.83 APE9-dihe-na 70.82, 169.1 APE8-dihe-in -122.85, 127.5 APE8-rot-in 297.91 APE67-dihe-inflip 117.64, -32.26 -39.31, 118.58 APE12-dist-none 999.0 APE11-dist-out 14.061 APE10-dist-out 9.312 APE9-dist-in 3.559 N772Y None None XRAY 2.9 0.202 0.234 A 435 388 17 0 0 12 [[571, 832]] 1.0 4pl3 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL3B Q9EQY0 562 963 977.0 31J:1001,ADP:1002 Allosteric,ATPlike Inactive DFGin 7.334 13.893 BLBplus -148.72, -173.45 55.21, 14.76 -81.6, 169.54 60.69, 84.7 79.59, -5.1 out-out out 16.58 Saltbr-out 13.289 HRD-in -77.64, -56.6 82.71, -30.85 out-out-out SNCooo out-out ActLoopNT-out 10.622 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -64.56, 166.09 APE9-dihe-na 91.33, -176.0 APE8-dihe-in -135.33, 135.79 APE8-rot-in 299.82 APE67-dihe-inflip 121.38, -25.98 -48.92, 119.9 APE12-dist-none 999.0 APE11-dist-out 14.123 APE10-dist-out 9.336 APE9-dist-in 3.695 N772Y None None XRAY 2.9 0.202 0.234 B 435 383 19 0 0 13 [[571, 832]] 1.0 4pl3 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL4A Q9EQY0 562 963 977.0 31K:1001,ADP:1002 Allosteric,ATPlike Inactive DFGin 6.788 14.219 BLBplus -105.14, -174.11 44.38, 29.11 -94.38, 143.46 69.8, 104.54 103.76, -33.08 out-out out 16.605 Saltbr-out 13.273 HRD-in -77.26, -47.59 71.94, -10.31 out-out-out SNCooo out-out ActLoopNT-out 10.563 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -61.91, 153.92 APE9-dihe-na 102.53, -174.53 APE8-dihe-in -133.87, 129.13 APE8-rot-in 297.04 APE67-dihe-inflip 119.89, -24.27 -52.28, 118.86 APE12-dist-none 999.0 APE11-dist-out 14.379 APE10-dist-out 9.432 APE9-dist-in 3.296 N772Y None None XRAY 3.0 0.213 0.276 A 435 385 17 0 0 11 [[571, 832]] 1.0 4pl4 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL5A Q9EQY0 562 964 977.0 31L:1001,ADP:1002,PEU:1004 Allosteric,ATPlike,Allosteric Inactive DFGin 6.585 13.755 BLBplus -127.28, -167.94 47.08, 28.46 -89.65, 160.5 62.46, 164.78 70.79, 0.93 out-out out 16.296 Saltbr-out 12.729 HRD-in -75.22, -42.28 71.55, -19.88 out-out-out SNCooo out-out ActLoopNT-out 10.486 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -69.09, -179.67 APE9-dihe-na 72.79, -173.9 APE8-dihe-in -128.85, 142.84 APE8-rot-in 291.98 APE67-dihe-inflip 114.76, -25.15 -48.2, 123.54 APE12-dist-none 999.0 APE11-dist-in 13.799 APE10-dist-out 8.597 APE9-dist-in 3.498 N772Y None None XRAY 3.4 0.225 0.285 A 435 386 17 0 0 12 [[571, 832]] 1.0 4pl5 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5 256 252 710 711 712 714 716 599 612 616 685 687 686 688 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
TYR EPHB2 EPHB2_MOUSE 2HENA P54763 614 893 986.0 ADP:60400 ATPlike None DFGin 5.333 15.674 BLAminus -133.74, -165.91 59.29, 70.83 -103.82, 9.51 292.63, 82.7 -87.21, 999.0 in-in in 8.023 Saltbr-in 2.786 HRD-in -62.88, -49.36 74.49, -21.92 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 78.77 APE8-rot-na 327.53 APE67-dihe-in -57.52, -8.41 -44.64, -64.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 D746A None None XRAY 2.6 0.205 0.26 A 286 258 22 0 0 22 [[621, 882]] 1.0 2hen Mus musculus TYR_EPHB2_MOUSE TYR 7e-108 365.8 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR EPHB2 EPHB2_MOUSE 2HENB P54763 614 893 986.0 ADP:60401 ATPlike None DFGin 4.876 14.888 BLAminus -140.27, -169.83 69.21, 92.69 -125.5, 35.8 302.49, 84.21 -59.5, 999.0 in-in in 8.267 Saltbr-in 2.839 HRD-in -71.96, -52.85 76.51, -19.64 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 70.95 APE8-rot-na 35.68 APE67-dihe-in -63.04, 8.29 -53.0, -58.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 D746A None None XRAY 2.6 0.205 0.26 B 286 258 22 0 0 22 [[621, 882]] 1.0 2hen Mus musculus TYR_EPHB2_MOUSE TYR 7e-108 365.8 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR EPHB2 EPHB2_MOUSE 2HENC P54763 614 893 986.0 ADP:60402 ATPlike None DFGin 5.167 15.787 BLAminus -136.6, -161.63 61.14, 70.93 -108.31, 8.65 286.35, 98.46 -79.82, 999.0 in-in in 8.074 Saltbr-in 2.876 HRD-in -60.04, -43.18 71.33, -24.11 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 75.37 APE8-rot-na 329.62 APE67-dihe-in -67.84, -7.2 -58.96, -40.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 D746A None None XRAY 2.6 0.205 0.26 C 286 258 22 0 0 22 [[621, 882]] 1.0 2hen Mus musculus TYR_EPHB2_MOUSE TYR 7e-108 365.8 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR EPHB2 EPHB2_MOUSE 2HEND P54763 614 893 986.0 ADP:60403 ATPlike None DFGin 4.79 14.772 BLAminus -150.33, -176.71 75.96, 94.04 -126.18, 89.85 307.58, 79.07 -67.67, 999.0 in-in in 8.322 Saltbr-in 3.409 HRD-in -71.43, -49.79 75.74, -24.02 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 92.49 APE8-rot-na 333.13 APE67-dihe-in -68.61, 6.13 -48.05, -54.94 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 D746A None None XRAY 2.6 0.205 0.26 D 286 258 22 0 0 22 [[621, 882]] 1.0 2hen Mus musculus TYR_EPHB2_MOUSE TYR 7e-108 365.8 2 261 260 763 764 765 767 769 653 670 674 743 745 744 746 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR JAK1-12 JAK1_MOUSE 7T6FA P52332 32 1153 1153.0 ADN:61201,ADP:61202 Allosteric,ATPlike Inactive DFGin 6.899 13.813 None -86.13, -125.98 -78.37, 170.67 -132.74, 42.36 300.4, 95.7 -63.52, -44.16 in-out in 8.266 Saltbr-out 5.345 HRD-in -74.55, -24.53 68.9, -7.15 out-in-out SNCoio in-out ActLoopNT-in 3.366 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -74.97, -30.61 APE9-dihe-in -69.86, 145.09 APE8-dihe-in -65.5, 154.45 APE8-rot-na 337.81 APE67-dihe-in -111.81, 34.03 -69.03, -47.03 APE12-dist-na 13.07 APE11-dist-na 13.989 APE10-dist-na 8.674 APE9-dist-in 6.36 None None None EM 3.6 999.0 999.0 A 1173 1043 23 0 0 0 [[582, 846], [874, 1150]] 2.0 7t6f Mus musculus TYR_JAK1-12_MOUSE TYR 7.5e-59 499.6 3 260 516 1019 1020 1021 1023 1025 907 924 928 999 1001 1000 1002 1062 1050 1045 1044 1043 1042 1041 1040 1039 956 Tyrosine-protein kinase JAK1
TYR JAK1-12 JAK1_MOUSE 7T6FB P52332 32 1153 1153.0 ADN:61201,ADP:61202 Allosteric,ATPlike Inactive DFGin 6.898 13.813 None -86.09, -125.95 -78.45, 170.72 -132.73, 42.29 300.45, 95.61 -63.42, -44.2 in-out in 8.267 Saltbr-out 5.347 HRD-in -74.65, -24.42 68.9, -7.11 out-in-out SNCoio in-out ActLoopNT-in 3.366 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -74.91, -30.65 APE9-dihe-in -69.79, 145.09 APE8-dihe-in -65.5, 154.47 APE8-rot-na 337.81 APE67-dihe-in -111.9, 34.05 -69.03, -46.98 APE12-dist-na 13.069 APE11-dist-na 13.989 APE10-dist-na 8.673 APE9-dist-in 6.36 None None None EM 3.6 999.0 999.0 B 1173 1043 23 0 0 0 [[582, 846], [874, 1150]] 2.0 7t6f Mus musculus TYR_JAK1-12_MOUSE TYR 7.5e-59 499.6 3 260 516 1019 1020 1021 1023 1025 907 924 928 999 1001 1000 1002 1062 1050 1045 1044 1043 1042 1041 1040 1039 956 Tyrosine-protein kinase JAK1
TYR JAK1-12 JAK1_MOUSE 8EWYA P52332 32 1153 1153.0 ADN:61201,ADP:61202 Allosteric,ATPlike Inactive None 999.0 999.0 None -138.68, -158.74 57.84, 53.41 -86.5, 17.2 999.0, 999.0 -66.33, -21.83 in-none in 8.079 Saltbr-none 999.0 HRD-in -63.86, -38.24 65.99, -1.42 none-in-in SNCnii in-in ActLoopNT-in 2.841 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.88, 139.03 APE9-dihe-in -137.63, 148.1 APE8-dihe-in -70.82, 80.23 APE8-rot-na 999.0 APE67-dihe-in -71.32, -12.38 -60.07, -30.97 APE12-dist-na 13.002 APE11-dist-na 7.928 APE10-dist-na 11.009 APE9-dist-in 6.342 V657F None None EM 5.5 999.0 999.0 A 1173 1047 19 0 0 0 [[582, 846], [874, 1150]] 2.0 8ewy Mus musculus TYR_JAK1-12_MOUSE TYR 7.5e-59 499.6 3 260 516 1019 1020 1021 1023 1025 907 924 928 999 1001 1000 1002 1062 1050 1045 1044 1043 1042 1041 1040 1039 956 Tyrosine-protein kinase JAK1
TYR JAK1-12 JAK1_MOUSE 8EWYB P52332 32 1153 1153.0 ADN:61201,ADP:61202 Allosteric,ATPlike Inactive None 999.0 999.0 None -138.65, -158.76 57.86, 53.37 -86.37, 17.05 999.0, 999.0 -66.24, -21.9 in-none in 8.079 Saltbr-none 999.0 HRD-in -63.87, -38.25 66.06, -1.5 none-in-in SNCnii in-in ActLoopNT-in 2.842 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.87, 139.06 APE9-dihe-in -137.62, 148.16 APE8-dihe-in -70.91, 80.26 APE8-rot-na 999.0 APE67-dihe-in -71.25, -12.38 -60.08, -31.01 APE12-dist-na 13.002 APE11-dist-na 7.928 APE10-dist-na 11.009 APE9-dist-in 6.341 V657F None None EM 5.5 999.0 999.0 B 1173 1047 19 0 0 0 [[582, 846], [874, 1150]] 2.0 8ewy Mus musculus TYR_JAK1-12_MOUSE TYR 7.5e-59 499.6 3 260 516 1019 1020 1021 1023 1025 907 924 928 999 1001 1000 1002 1062 1050 1045 1044 1043 1042 1041 1040 1039 956 Tyrosine-protein kinase JAK1
TYR SRC SRC_MOUSE 8XN8A P05480 85 534 535.0 ADP:601 ATPlike Inactive DFGin 5.828 13.233 BLBplus -120.06, 161.26 65.68, 32.74 -74.22, 143.59 39.08, 88.47 84.86, -35.8 out-out out 13.986 Saltbr-out 13.922 HRD-in -73.69, -59.12 84.41, -7.57 out-out-out SNCooo out-out ActLoopNT-out 7.405 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.24, -6.02 APE9-dihe-in -94.54, 127.69 APE8-dihe-in -80.44, 65.55 APE8-rot-na 33.74 APE67-dihe-in -67.14, -17.8 -57.51, -33.8 APE12-dist-na 17.699 APE11-dist-na 18.558 APE10-dist-na 13.373 APE9-dist-out 8.71 None PTR529 PTR529 XRAY 1.95 0.187 0.224 A 451 450 0 0 0 0 [[269, 520]] 1.0 8xn8 Mus musculus TYR_SRC_MOUSE TYR 8.8e-94 319.8 1 260 260 405 406 407 409 411 297 312 316 385 387 386 388 446 434 429 428 427 426 425 424 423 341 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_MOUSE 6F3FA P05480 85 531 535.0 ADP:60601 ATPlike Inactive DFGin 5.729 13.263 BLBplus -129.36, 166.09 58.36, 35.58 -80.98, 135.75 39.82, 82.45 82.86, -9.54 out-out out 14.175 Saltbr-out 14.398 HRD-in -79.21, -57.39 83.57, -8.9 out-out-out SNCooo out-out ActLoopNT-out 7.29 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -111.04, 2.76 APE9-dihe-in -98.67, 129.97 APE8-dihe-in -74.19, 70.52 APE8-rot-na 30.31 APE67-dihe-in -76.25, -9.79 -62.62, -30.23 APE12-dist-na 17.526 APE11-dist-na 18.723 APE10-dist-na 13.526 APE9-dist-out 8.548 None PTR529 PTR529 XRAY 2.418 0.211 0.268 A 455 447 0 0 0 0 [[269, 520]] 1.0 6f3f Mus musculus TYR_SRC_MOUSE TYR 9e-94 319.7 1 260 260 405 406 407 409 411 297 312 316 385 387 386 388 446 434 429 428 427 426 425 424 423 341 Proto-oncogene tyrosine-protein kinase Src
OTHER PKNB PKNB_MYCTU 3F61A P9WI81 1 290 626.0 ADP:340 ATPlike Inactive DFGin 10.408 16.823 BLBminus -141.07, 168.15 65.97, 58.12 -87.1, 145.62 281.84, 72.93 89.1, 11.07 in-out in 9.933 Saltbr-out 6.777 HRD-in -66.51, -54.56 82.27, -14.45 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -63.4, -20.65 999.0, 0.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 L33D,V222D None None XRAY 1.8 0.205 0.228 A 311 271 19 0 0 19 [[11, 273]] 1.0 3f61 Mycobacterium tuberculosis OTHER_PKNB_MYCTU CAMK 1.6e-46 164.7 1 248 248 155 156 157 159 161 40 59 63 135 137 136 138 198 186 181 180 179 178 177 176 175 93 Serine/threonine-protein kinase PknB
OTHER PKNG PKNG_MYCTU 4Y0XA P9WI73 83 404 750.0 ADP:501 ATPlike Inactive DFGin 6.727 11.534 BLAminus -117.75, -169.01 53.44, 71.03 -83.15, 12.14 305.33, 8.75 -59.16, -32.06 out-out out 15.116 Saltbr-out 15.059 HRD-in -73.44, -41.15 68.04, -13.32 out-in-out SNCoio in-out ActLoopNT-in 2.777 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -55.23, 147.28 APE9-dihe-na -174.26, 176.21 APE8-dihe-in -98.04, 125.35 APE8-rot-in 298.01 APE67-dihe-inflip 105.55, -13.26 -56.87, 129.33 APE12-dist-out 5.542 APE11-dist-in 10.154 APE10-dist-in 7.371 APE9-dist-in 5.79 None None None XRAY 1.74 0.198 0.209 A 375 322 0 0 0 0 [[151, 345]] 1.0 4y0x Mycobacterium tuberculosis OTHER_PKNG_MYCTU CAMK 8.2e-22 86.0 1 186 186 292 293 294 296 298 181 198 202 273 275 274 276 327 316 311 310 309 308 307 306 305 233 Serine/threonine-protein kinase PknG
OTHER PKNI PKNI_MYCTU 5M06B P9WI69 2 255 585.0 ADP:301 ATPlike Inactive DFGin 8.316 16.631 BLBminus -112.52, 166.29 60.43, 51.53 -60.28, 125.48 270.62, 84.02 56.24, 31.01 out-out out 14.989 Saltbr-out 14.394 HRD-in -80.29, -52.43 77.96, -9.32 out-out-out SNCooo out-out ActLoopNT-out 11.53 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-out -70.34, -46.82 -66.42, 150.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.213 0.239 B 276 248 3 0 0 0 [[12, 175]] 1.0 5m06 Mycobacterium tuberculosis OTHER_PKNI_MYCTU CAMK 1.3e-18 76.4 1 201 201 158 159 160 162 164 41 60 64 134 136 135 137 184 172 167 166 0 0 0 0 0 90 Serine/threonine-protein kinase PknI
STE MAP2K1 MP2K1_RABIT 7JUQC P29678 40 381 393.0 ADP:401 ATPlike Inactive DFGin 6.586 14.742 BLBplus -129.84, -170.1 45.36, 32.9 -86.02, 164.53 43.64, 99.66 -81.97, 72.94 out-out out 15.573 Saltbr-out 14.639 HRD-in -71.73, -54.6 83.98, -10.27 out-out-out SNCooo out-out ActLoopNT-out 9.817 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -103.97, 121.68 APE9-dihe-na -107.28, -138.86 APE8-dihe-out -101.2, -25.18 APE8-rot-out 36.43 APE67-dihe-out -125.05, 133.16 -97.84, 131.49 APE12-dist-out 16.466 APE11-dist-out 18.834 APE10-dist-out 20.472 APE9-dist-out 14.688 None None None XRAY 3.22 0.256 0.288 C 384 305 37 0 0 0 [[68, 361]] 1.0 7juq Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
OTHER FLS2 FLS2_ORYSJ 8JUVA Q0JA29 861 1178 1183.0 ADP:60601 ATPlike Inactive DFGin 6.15 14.327 BLAminus -130.59, 177.4 65.69, 86.01 -100.39, 23.88 290.69, 79.09 -65.0, -14.14 in-in in 8.025 Saltbr-in 2.76 HRD-in -70.78, -47.74 78.11, -0.08 in-in-out SNCiio in-out ActLoopNT-in 2.747 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -103.82, 168.59 APE9-dihe-na 62.78, -132.62 APE8-dihe-out -74.57, -16.63 APE8-rot-out 44.07 APE67-dihe-in -63.03, -19.63 -66.3, -33.92 APE12-dist-out 23.725 APE11-dist-out 18.691 APE10-dist-out 19.68 APE9-dist-out 12.255 None None MSE903,MSE959,MSE1037,MSE1066,MSE1073,MSE1090,MSE1134,MSE1166,MSE1176 XRAY 2.09 0.183 0.208 A 339 288 30 0 0 16 [[874, 1175]] 1.0 8juv Oryza sativa OTHER_FLS2_ORYSJ TKL 3.7e-44 157.3 4 265 262 1030 1031 1032 1034 1036 908 926 930 1010 1012 1011 1013 1081 1069 1064 1063 1062 1061 1060 1059 1058 957 LRR receptor-like serine/threonine-protein kinase FLS2
OTHER PINK1 PINK1_PEDHC 8UYIA E0W1I1 120 572 575.0 ADP:601 ATPlike Active DFGin 9.472 14.492 BLAminus -126.54, -170.24 58.08, 66.04 -87.71, 25.91 289.34, 85.25 -66.89, -21.8 in-in in 7.734 Saltbr-in 2.489 HRD-in -72.82, -45.28 62.7, 4.34 in-in-in SNCiii in-in ActLoopNT-in 2.793 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na 149.48, -127.57 APE9-dihe-na -109.63, -105.35 APE8-dihe-in -70.24, 160.24 APE8-rot-na 51.46 APE67-dihe-in -90.34, -42.74 -107.64, 8.21 APE12-dist-in 8.485 APE11-dist-in 10.413 APE10-dist-in 5.828 APE9-dist-in 3.643 None SEP202,TPO305 SEP202,TPO305 EM 3.13 999.0 999.0 A 463 369 49 0 0 0 [[64, 514]] 1.0 8uyi Pediculus humanus OTHER_PINK1_PEDHC PINK1 1e-86 297.1 4 367 364 356 357 358 360 362 193 214 218 331 333 332 334 408 390 385 384 383 382 381 380 379 291 Serine/threonine-protein kinase Pink1, mitochondrial
OTHER PINK1 PINK1_PEDHC 8UYIB E0W1I1 122 574 575.0 ADP:601 ATPlike Active DFGin 9.37 14.767 BLAminus -128.32, -168.79 58.11, 64.54 -83.54, 12.33 278.78, 92.3 -66.63, -13.93 in-in in 8.001 Saltbr-in 2.363 HRD-in -66.42, -44.15 62.85, 2.17 in-in-in SNCiii in-in ActLoopNT-in 2.974 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na 143.29, -143.85 APE9-dihe-na -111.19, -100.88 APE8-dihe-in -71.36, 134.31 APE8-rot-na 50.34 APE67-dihe-in -67.38, -41.28 -74.79, -24.08 APE12-dist-in 8.473 APE11-dist-in 10.806 APE10-dist-in 6.227 APE9-dist-in 3.553 None SEP202,TPO305 SEP202,TPO305 EM 3.13 999.0 999.0 B 463 369 51 0 0 0 [[64, 514]] 1.0 8uyi Pediculus humanus OTHER_PINK1_PEDHC PINK1 1e-86 297.1 4 367 364 356 357 358 360 362 193 214 218 331 333 332 334 408 390 385 384 383 382 381 380 379 291 Serine/threonine-protein kinase Pink1, mitochondrial
AGC PRKACA KAPCA_RAT 3TNQB P27791 18 351 351.0 ADP:60400 ATPlike Inactive DFGin 6.026 14.109 ABAminus -114.77, -42.68 -116.73, 98.61 -86.63, 16.07 279.08, 57.74 -59.27, -13.09 in-in in 8.765 Saltbr-in 3.295 HRD-in -83.62, -53.15 67.05, 14.07 in-in-in SNCiii in-in ActLoopNT-in 3.015 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.54, 167.18 APE9-dihe-na 139.44, -131.54 APE8-dihe-in -144.99, 127.08 APE8-rot-in 312.05 APE67-dihe-in -55.59, -13.34 -44.48, -54.97 APE12-dist-in 8.095 APE11-dist-in 11.457 APE10-dist-in 6.181 APE9-dist-in 3.589 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 3.097 0.234 0.275 B 350 334 0 0 0 0 [[44, 298]] 1.0 3tnq Rattus norvegicus AGC_PRKACA_RAT AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CMGC MAPK1 MK01_RAT 4GVAA P63086 11 356 358.0 ADP:401 ATPlike Inactive DFGin 6.702 16.769 BLAminus -137.11, 178.59 63.89, 77.38 -94.14, 25.17 286.58, 79.57 -59.17, -35.22 out-out out 10.492 Saltbr-out 6.521 HRD-in -67.64, -55.15 72.72, 9.25 out-in-in SNCoii in-in ActLoopNT-in 2.83 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.68, -13.3 APE9-dihe-na -77.88, 161.53 APE8-dihe-in -56.04, 126.28 APE8-rot-in 320.84 APE67-dihe-in -66.77, -13.08 -47.2, -54.23 APE12-dist-in 13.845 APE11-dist-in 11.05 APE10-dist-in 7.148 APE9-dist-in 4.198 None None CME159 XRAY 1.83 0.191 0.241 A 364 346 0 0 0 0 [[23, 311]] 1.0 4gva Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.4e-85 293.1 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC FUS3 FUS3_YEAST 2B9HA P16892 1 353 353.0 ADP:500 ATPlike Inactive DFGin 6.283 13.764 BLAminus -136.62, -177.7 68.6, 65.84 -94.91, 10.48 297.74, 102.72 -75.81, -10.99 in-in in 8.564 Saltbr-in 2.732 HRD-in -74.04, -48.55 74.11, -6.87 in-in-out SNCiio in-out ActLoopNT-in 2.932 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -116.55, 132.5 APE9-dihe-na -63.29, 147.56 APE8-dihe-in -50.7, 127.74 APE8-rot-in 296.79 APE67-dihe-in -63.13, -20.59 -60.61, -24.81 APE12-dist-in 8.605 APE11-dist-out 6.693 APE10-dist-out 9.836 APE9-dist-in 4.75 T180V,Y182F None None XRAY 1.55 0.187 0.216 A 353 337 16 0 0 16 [[13, 309]] 1.0 2b9h Saccharomyces cerevisiae CMGC_FUS3_YEAST CMGC 2.2e-73 253.2 3 301 299 154 155 156 158 160 42 59 63 134 136 135 137 205 192 187 186 185 184 183 182 181 94 Mitogen-activated protein kinase FUS3
CMGC FUS3 FUS3_YEAST 2B9IA P16892 1 353 353.0 ADP:500 ATPlike Inactive DFGin 6.365 14.066 BLAminus -135.63, 178.36 68.62, 72.5 -98.81, 8.36 296.13, 97.35 -58.15, -32.2 in-in in 8.702 Saltbr-in 2.95 HRD-in -67.33, -47.39 70.79, -9.55 in-in-out SNCiio in-out ActLoopNT-in 2.954 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -112.27, 137.29 APE9-dihe-na -73.31, 133.1 APE8-dihe-in -36.03, 128.5 APE8-rot-in 289.53 APE67-dihe-in -68.8, -14.68 -68.0, -19.59 APE12-dist-in 8.905 APE11-dist-out 6.581 APE10-dist-out 9.961 APE9-dist-in 4.55 T180V,Y182F None None XRAY 2.5 0.202 0.279 A 353 338 15 0 0 15 [[13, 309]] 1.0 2b9i Saccharomyces cerevisiae CMGC_FUS3_YEAST CMGC 2.2e-73 253.2 3 301 299 154 155 156 158 160 42 59 63 134 136 135 137 205 192 187 186 185 184 183 182 181 94 Mitogen-activated protein kinase FUS3
CMGC FUS3 FUS3_YEAST 2B9JA P16892 1 353 353.0 ADP:500 ATPlike Inactive DFGin 6.547 13.868 BLAminus -134.9, -176.68 60.68, 67.3 -98.24, 14.73 302.06, 96.25 -69.67, -26.86 in-in in 8.701 Saltbr-in 2.96 HRD-in -72.32, -48.06 70.0, -6.29 in-in-out SNCiio in-out ActLoopNT-in 2.966 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -102.32, 139.79 APE9-dihe-na -71.76, 150.07 APE8-dihe-in -56.91, 118.63 APE8-rot-in 300.43 APE67-dihe-in -59.09, -25.02 -50.5, -31.25 APE12-dist-in 8.853 APE11-dist-out 6.593 APE10-dist-out 10.065 APE9-dist-in 4.766 T180V,Y182F None None XRAY 2.3 0.196 0.263 A 353 337 16 0 0 16 [[13, 309]] 1.0 2b9j Saccharomyces cerevisiae CMGC_FUS3_YEAST CMGC 2.2e-73 253.2 3 301 299 154 155 156 158 160 42 59 63 134 136 135 137 205 192 187 186 185 184 183 182 181 94 Mitogen-activated protein kinase FUS3
CMGC FUS3 FUS3_YEAST 2B9FA P16892 1 353 353.0 ADP:500 ATPlike Inactive DFGin 6.319 13.814 BLAminus -136.19, -174.38 64.52, 61.38 -89.09, 7.19 299.63, 104.82 -67.16, -21.09 in-in in 8.611 Saltbr-in 2.683 HRD-in -75.04, -47.21 75.53, -13.96 in-in-out SNCiio in-out ActLoopNT-in 3.045 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -129.66, 156.16 APE9-dihe-na -66.55, 158.23 APE8-dihe-in -56.07, 140.2 APE8-rot-in 288.73 APE67-dihe-in -58.7, -27.3 -59.52, -33.17 APE12-dist-in 8.681 APE11-dist-out 5.798 APE10-dist-out 8.573 APE9-dist-in 4.092 None None None XRAY 1.8 0.213 0.259 A 353 337 16 0 0 16 [[13, 309]] 1.0 2b9f Saccharomyces cerevisiae CMGC_FUS3_YEAST CMGC 5.2e-75 258.5 3 301 299 154 155 156 158 160 42 59 63 134 136 135 137 205 192 187 186 185 184 183 182 181 94 Mitogen-activated protein kinase FUS3
CMGC FUS3 FUS3_YEAST 2F9GA P16892 1 353 353.0 ADP:500 ATPlike None DFGin 6.607 14.033 BLAminus -131.87, -173.96 62.19, 67.37 -94.01, 7.54 292.42, 102.61 -61.43, -28.32 in-in in 8.738 Saltbr-in 2.766 HRD-in -77.05, -50.83 75.67, -3.23 in-in-none SNCiin in-none ActLoopNT-in 2.955 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.43 APE8-rot-in 296.4 APE67-dihe-in -62.22, -26.66 -58.62, -16.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None PTR182 PTR182 XRAY 2.1 0.211 0.26 A 353 332 21 0 0 21 [[13, 309]] 1.0 2f9g Saccharomyces cerevisiae CMGC_FUS3_YEAST CMGC 5.2e-75 258.5 3 301 299 154 155 156 158 160 42 59 63 134 136 135 137 205 192 187 186 185 184 183 182 181 94 Mitogen-activated protein kinase FUS3
CMGC KIN28 KIN28_YEAST 6XI8A P06242 6 303 306.0 ADP:401 ATPlike Inactive DFGin 5.502 15.444 BLAminus -145.77, -169.62 57.83, 69.55 -84.3, 48.2 280.55, 74.99 -75.72, -28.64 in-out in 8.952 Saltbr-out 3.667 HRD-out 58.01, 71.8 -89.69, 32.34 out-in-out SNCoio in-out ActLoopNT-in 2.701 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -116.0, -16.75 APE9-dihe-na -128.02, 157.65 APE8-dihe-in -70.96, 169.95 APE8-rot-out 44.23 APE67-dihe-in -79.03, -7.97 -69.89, -44.72 APE12-dist-in 12.387 APE11-dist-in 10.704 APE10-dist-in 6.15 APE9-dist-in 3.44 None TPO162 TPO162 EM 3.64 999.0 999.0 A 301 290 8 0 0 0 [[7, 290]] 1.0 6xi8 Saccharomyces cerevisiae CMGC_KIN28_YEAST CMGC 4.1e-70 242.3 1 301 301 146 147 148 150 152 36 54 58 126 128 127 129 187 174 169 168 167 166 165 164 163 84 Serine/threonine-protein kinase KIN28
CMGC KIN28 KIN28_YEAST 7KUEA P06242 6 303 306.0 ADP:401 ATPlike Inactive DFGin 5.502 15.444 BLAminus -145.81, -169.57 57.84, 69.51 -84.28, 48.19 280.53, 74.97 -75.72, -28.63 in-out in 8.952 Saltbr-out 3.667 HRD-out 58.03, 71.82 -89.76, 32.34 out-in-out SNCoio in-out ActLoopNT-in 2.702 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -115.99, -16.84 APE9-dihe-na -127.96, 157.63 APE8-dihe-in -70.94, 169.94 APE8-rot-out 44.25 APE67-dihe-in -79.07, -7.97 -69.92, -44.62 APE12-dist-in 12.386 APE11-dist-in 10.705 APE10-dist-in 6.15 APE9-dist-in 3.44 None TPO162 TPO162 EM 3.5 999.0 999.0 A 306 290 8 0 0 0 [[7, 290]] 1.0 7kue Saccharomyces cerevisiae CMGC_KIN28_YEAST CMGC 4.4e-70 242.3 1 301 301 146 147 148 150 152 36 54 58 126 128 127 129 187 174 169 168 167 166 165 164 163 84 Serine/threonine-protein kinase KIN28
CMGC SKY1 SKY1_YEAST 1Q8YA Q03656 144 737 742.0 ADP:60810 ATPlike Active DFGin 5.554 12.776 BLAminus -120.8, -179.55 50.32, 80.87 -92.72, 24.06 294.38, 19.86 -63.4, -18.16 in-in in 8.712 Saltbr-in 2.74 HRD-in -75.73, -45.78 71.18, -6.61 in-in-in SNCiii in-in ActLoopNT-in 2.965 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.41, 175.98 APE9-dihe-na 63.08, 152.12 APE8-dihe-in -90.87, 131.26 APE8-rot-in 290.95 APE67-dihe-in -56.18, -26.85 -9.03, -76.03 APE12-dist-in 12.534 APE11-dist-in 10.496 APE10-dist-in 7.507 APE9-dist-in 2.99 None None None XRAY 2.05 0.209 0.244 A 373 351 11 0 0 0 [[158, 706]] 1.0 1q8y Saccharomyces cerevisiae CMGC_SKY1_YEAST CMGC 8.8e-100 339.7 1 301 301 549 550 551 553 555 187 202 206 291 293 292 294 586 574 569 568 567 566 565 564 563 247 Serine/threonine-protein kinase SKY1
OTHER BUD32 BUD32_YEAST 4WW9A P53323 4 259 261.0 ADP:302 ATPlike Active DFGin 6.618 15.283 BLAminus -128.14, 172.87 62.95, 73.82 -100.2, 23.36 281.69, 91.54 -52.55, -36.42 in-in in 7.602 Saltbr-in 2.744 HRD-in -80.98, -51.42 97.59, -12.36 in-in-na SNCiia in-na ActLoopNT-in 2.852 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -61.46, -46.34 APE9-dihe-na -60.52, -40.33 APE8-dihe-na -68.91, -38.47 APE8-rot-na 168.71 APE67-dihe-na -62.48, -38.16 -54.4, -51.68 APE12-dist-na 15.732 APE11-dist-na 11.179 APE10-dist-na 14.687 APE9-dist-na 11.734 None None None XRAY 1.951 0.18 0.209 A 261 238 20 0 0 0 [[17, 261]] 1.0 4ww9 Saccharomyces cerevisiae OTHER_BUD32_YEAST TP53RK 5e-44 156.6 8 224 217 181 182 183 185 187 52 76 80 158 160 159 161 198 204 199 198 197 196 195 194 193 107 EKC/KEOPS complex subunit BUD32
OTHER CDC7 CDC7_YEAST 7PT78 P06243 10 475 507.0 ADP:1001,BEF:1003 ATPlike,Allosteric Inactive DFGin 7.05 14.828 ABAminus -125.48, -62.19 -62.72, 136.55 -132.76, 24.05 270.26, 81.1 -56.4, -43.64 in-out in 8.956 Saltbr-out 6.838 HRD-out -95.15, 91.19 -59.72, -45.2 out-in-out SNCoio in-out ActLoopNT-in 2.418 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiii APE10-dihe-na -63.65, 141.8 APE9-dihe-na 169.57, -141.23 APE8-dihe-in -138.07, 164.32 APE8-rot-in 301.9 APE67-dihe-out 82.72, -175.36 -64.25, 106.81 APE12-dist-in 8.854 APE11-dist-in 11.015 APE10-dist-in 5.043 APE9-dist-in 4.626 None None None EM 3.8 999.0 999.0 8 507 402 64 0 0 46 [[33, 469]] 1.0 7pt7 Saccharomyces cerevisiae OTHER_CDC7_YEAST CMGC 4e-17 121.0 1 158 260 181 182 183 185 187 76 90 94 160 162 161 163 301 288 283 282 281 280 279 278 277 121 Cell division control protein 7
OTHER IRE1 IRE1_YEAST 2RIOA P32361 665 1115 1115.0 ADP:61101 ATPlike None DFGin 5.032 14.666 BLAminus -125.01, -166.82 59.91, 72.41 -79.74, 13.1 278.94, 57.84 -50.86, -29.29 out-in out 10.36 Saltbr-in 3.544 HRD-in -69.38, -55.95 80.27, 5.91 in-in-none SNCiin in-none ActLoopNT-in 2.684 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 148.77 APE8-rot-in 240.38 APE67-dihe-in -59.81, -10.2 -102.36, 14.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.224 0.266 A 434 396 26 0 0 14 [[672, 977]] 1.0 2rio Saccharomyces cerevisiae OTHER_IRE1_YEAST TKL 1e-35 129.7 4 263 260 827 828 829 831 833 702 715 719 794 796 795 797 902 859 854 853 852 851 850 849 848 746 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER IRE1 IRE1_YEAST 2RIOB P32361 665 1115 1115.0 ADP:62101 ATPlike Inactive DFGin 5.132 14.401 BLAminus -133.23, -169.67 57.3, 77.4 -91.55, 18.06 279.67, 55.41 -50.86, -27.7 in-in in 9.967 Saltbr-in 3.554 HRD-in -79.44, -44.63 66.11, 11.75 in-in-out SNCiio in-out ActLoopNT-in 2.764 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 139.02 APE8-rot-out 206.66 APE67-dihe-in -67.78, -12.45 -143.81, 21.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.224 0.266 B 434 395 27 0 0 14 [[672, 977]] 1.0 2rio Saccharomyces cerevisiae OTHER_IRE1_YEAST TKL 1e-35 129.7 4 263 260 827 828 829 831 833 702 715 719 794 796 795 797 902 859 854 853 852 851 850 849 848 746 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER IRE1 IRE1_YEAST 3LJ0A P32361 665 1115 1115.0 ADP:2101,QUE:1 ATPlike,Allosteric None DFGin 5.657 14.52 BLAminus -127.75, -159.8 55.73, 76.2 -100.97, 26.65 278.19, 55.54 -68.42, -38.12 in-in in 9.315 Saltbr-in 3.043 HRD-in -75.54, -40.03 69.65, -11.03 in-in-none SNCiin in-none ActLoopNT-in 2.884 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -61.99 APE8-rot-none 999.0 APE67-dihe-in -81.59, -8.09 -104.48, 18.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP840,SEP841,TPO844 SEP840,SEP841,TPO844 XRAY 3.2 0.217 0.224 A 434 407 20 0 0 7 [[672, 977]] 1.0 3lj0 Saccharomyces cerevisiae OTHER_IRE1_YEAST TKL 1e-35 129.7 4 263 260 827 828 829 831 833 702 715 719 794 796 795 797 902 859 854 853 852 851 850 849 848 746 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER IRE1 IRE1_YEAST 3LJ0B P32361 670 1115 1115.0 ADP:2101,QUE:1 ATPlike,Allosteric None DFGin 5.639 14.529 BLAminus -127.76, -160.17 56.44, 75.29 -99.49, 26.48 278.86, 54.86 -67.91, -37.63 in-in in 9.332 Saltbr-in 3.088 HRD-in -76.48, -40.82 70.18, -10.34 in-in-none SNCiin in-none ActLoopNT-in 2.864 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -62.45 APE8-rot-in 292.53 APE67-dihe-in -81.7, -8.3 -104.03, 18.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP840,SEP841,TPO844 SEP840,SEP841,TPO844 XRAY 3.2 0.217 0.224 B 434 402 20 0 0 7 [[672, 977]] 1.0 3lj0 Saccharomyces cerevisiae OTHER_IRE1_YEAST TKL 1e-35 129.7 4 263 260 827 828 829 831 833 702 715 719 794 796 795 797 902 859 854 853 852 851 850 849 848 746 Serine/threonine-protein kinase/endoribonuclease IRE1
TYR VKR2 A0A3Q0KQ92_SCHMA 7ZVSA A0A3Q0KQ92 943 1257 1641.0 ADP:1301 ATPlike Inactive DFGin 6.411 13.912 ABAminus -108.2, -51.57 -108.14, 130.38 -125.76, 34.81 311.68, 99.72 -69.75, -23.67 in-out in 7.915 Saltbr-out 4.434 HRD-in -84.85, -39.64 60.03, 4.72 out-in-none SNCoin in-none ActLoopNT-in 3.115 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.51 APE8-dihe-in -86.18, 75.72 APE8-rot-na 32.5 APE67-dihe-in -65.42, -24.56 -66.74, -36.8 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.654 None None None XRAY 3.07 0.219 0.252 A 341 300 15 0 0 15 [[966, 1240]] 1.0 7zvs Schistosoma mansoni TYR_VKR2_SCHMA TYR 2.6e-69 239.5 1 253 253 1117 1118 1119 1121 1123 997 1014 1018 1097 1099 1098 1100 1162 1150 1145 1144 1143 1142 1141 1140 1139 1045 Guanylate cyclase
TYR VKR2 A0A3Q0KQ92_SCHMA 7ZVSB A0A3Q0KQ92 946 1257 1641.0 ADP:1301 ATPlike Inactive DFGin 6.622 14.521 ABAminus -98.3, -71.59 -103.46, 126.3 -111.19, 44.98 301.93, 110.43 -72.41, -47.73 in-in in 8.989 Saltbr-in 3.592 HRD-in -85.3, -43.46 65.5, -4.13 in-in-none SNCiin in-none ActLoopNT-in 3.168 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 149.82 APE9-dihe-in -99.67, 136.73 APE8-dihe-in -75.43, 94.78 APE8-rot-na 28.24 APE67-dihe-in -74.95, -28.65 -71.49, -32.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.774 APE9-dist-in 6.6 None None None XRAY 3.07 0.219 0.252 B 341 296 16 0 0 16 [[966, 1240]] 1.0 7zvs Schistosoma mansoni TYR_VKR2_SCHMA TYR 2.6e-69 239.5 1 253 253 1117 1118 1119 1121 1123 997 1014 1018 1097 1099 1098 1100 1162 1150 1145 1144 1143 1142 1141 1140 1139 1045 Guanylate cyclase
OTHER None A0ACD6BAW3_SERSF 5X1TA A0ACD6BAW3 11 298 302.0 ADP:401 ATPlike Inactive DFGin 5.685 14.725 ABAminus -97.25, -25.38 -172.38, 138.13 -106.62, 0.72 301.84, 142.37 67.65, 22.31 in-out in 9.742 Saltbr-out 4.566 HRD-in -80.43, -61.43 72.68, 8.5 out-out-out SNCooo out-out ActLoopNT-out 13.688 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oioo APE10-dihe-na -90.57, -68.65 APE9-dihe-na -94.13, 157.67 APE8-dihe-in -100.03, 111.72 APE8-rot-na 290.95 APE67-dihe-inflip 91.11, -26.21 -58.77, 131.47 APE12-dist-out 15.32 APE11-dist-in 10.432 APE10-dist-out 9.649 APE9-dist-out 6.242 None None None XRAY 1.55 0.203 0.229 A 302 283 5 0 0 0 [[23, 295]] 1.0 5x1t Serratia sp. OTHER_None_SERSF NEK 2.2e-22 86.3 1 248 248 182 183 184 186 188 52 89 93 162 164 163 165 225 210 205 204 203 202 201 200 199 119 PpkA N terminal
OTHER YOPO Q93KQ6_YEREN 5CE3B Q93KQ6 108 729 729.0 ADP:60801 ATPlike Inactive None 999.0 999.0 None -135.72, -178.29 65.55, 68.88 -88.43, 18.62 274.24, 50.39 -58.33, -41.28 none-na none 999.0 Saltbr-na 999.0 HRD-in -75.96, -46.65 74.34, -12.04 na-in-out SNCaio in-out ActLoopNT-in 2.931 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ooii APE10-dihe-na -168.45, -171.64 APE9-dihe-na -171.12, 163.26 APE8-dihe-in -100.11, 126.72 APE8-rot-in 306.6 APE67-dihe-in -62.68, -33.12 -66.23, -36.58 APE12-dist-out 6.894 APE11-dist-out 3.817 APE10-dist-in 5.185 APE9-dist-in 3.949 K205Y,E206Y,E207Y,K440Y,K441Y None None XRAY 2.93 0.198 0.24 B 643 598 0 0 0 0 [[144, 405]] 1.0 5ce3 Yersinia enterocolitica OTHER_YOPO_YEREN STE 4.1e-06 32.8 55 256 202 285 286 287 289 291 0 0 0 264 266 265 267 321 308 303 302 301 300 299 298 297 212 YopO
OTHER YOPO Q93KQ6_YEREN 5CE3D Q93KQ6 108 729 729.0 ADP:60801 ATPlike Inactive None 999.0 999.0 None -137.87, -178.9 65.7, 69.62 -87.46, 18.2 287.37, 172.47 -59.1, -40.66 none-na none 999.0 Saltbr-na 999.0 HRD-in -75.41, -46.8 73.5, -11.21 na-in-out SNCaio in-out ActLoopNT-in 2.923 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ooii APE10-dihe-na -169.34, -172.42 APE9-dihe-na -171.36, 163.27 APE8-dihe-in -100.95, 126.72 APE8-rot-in 306.77 APE67-dihe-in -63.23, -33.24 -66.66, -36.24 APE12-dist-out 6.877 APE11-dist-out 3.815 APE10-dist-in 5.173 APE9-dist-in 3.938 K205Y,E206Y,E207Y,K440Y,K441Y None None XRAY 2.93 0.198 0.24 D 643 598 0 0 0 0 [[144, 405]] 1.0 5ce3 Yersinia enterocolitica OTHER_YOPO_YEREN STE 4.1e-06 32.8 55 256 202 285 286 287 289 291 0 0 0 264 266 265 267 321 308 303 302 301 300 299 298 297 212 YopO