Ligand: ADP

Total number of chains: 206
Active chains: 71
Total number of genes: 47
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 161 78.2% 6YZHA
DFGin BLBplus 17 8.3% 4M15A
DFGin None 13 6.3% 4RIYD
DFGin ABAminus 5 2.4% 3LCTA
DFGinter None 4 1.9% 5L8LA
DFGin BLBminus 3 1.5% 8PR7D
None None 3 1.5% 2W5AA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC CDC42BPB MRCKB_HUMAN 4UAKA Q9Y5S2 2 417 1711.0 ADP:60501 ATPlike Active DFGin 6.5356 13.3888 BLAminus -126.67, 169.91 71.43, 81.15 -99.11, 14.11 300.02, 102.96 -73.12, -5.53 in-in in 8.6348 Saltbr-in 2.7478 HRD-in -78.82, -49.28 69.95, 4.01 in-in-in SNCiii in-in ActLoopNT-in 2.9773 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.28, 157.85 APE9-dihe-na 87.21, -164.86 APE8-dihe-in -127.15, 132.61 APE8-rot-in 302.21 APE67-dihe-in -64.23, -20.61 -57.86, -36.49 APE12-dist-in 10.5108 APE11-dist-in 11.1514 APE10-dist-in 6.3128 APE9-dist-in 3.5478 None None None XRAY 1.73 0.198 0.243 A 419.0 401.0 0 29 29 0 [[76, 342]] 1.0 4uak AGC_CDC42BPB_HUMAN AGC 6.5e-96 326.4 1.0 260.0 260.0 217 218 219 221 223 105 124 128 197 199 198 200.0 263 246 241 240 239 238 237 236 235 154 Serine/threonine-protein kinase MRCK beta
AGC PRKCI KPCI_HUMAN 5LIHA P41743 248 588 596.0 ADP:60601 ATPlike Active DFGin 5.4026 11.8632 BLAminus -129.58, 178.7 63.64, 84.98 -106.19, 67.5 320.36, 105.86 -96.86, -30.05 in-in in 9.1779 Saltbr-in 3.0311 HRD-in -49.42, -59.61 61.3, 24.72 in-in-in SNCiii in-in ActLoopNT-in 3.1093 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.76, 169.43 APE9-dihe-na 122.35, -170.42 APE8-dihe-in -91.96, 136.55 APE8-rot-in 289.3 APE67-dihe-in -72.22, -23.04 -49.75, -40.52 APE12-dist-in 7.983 APE11-dist-in 10.9856 APE10-dist-in 5.4207 APE9-dist-in 3.5596 None TPO412,TPO564 TPO412,TPO564 XRAY 3.25 0.258 0.284 A 349.0 326.0 15 28 28 0 [[254, 522]] 1.0 5lih AGC_PRKCI_HUMAN AGC 1.1e-95 325.5 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 5LIHB P41743 249 588 596.0 ADP:60601 ATPlike Active DFGin 5.3101 11.8759 BLAminus -129.18, 178.42 63.46, 84.62 -106.43, 67.35 320.63, 105.98 -96.29, -29.69 in-in in 8.7197 Saltbr-in 2.5445 HRD-in -49.62, -59.64 61.27, 24.64 in-in-in SNCiii in-in ActLoopNT-in 3.1408 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.47, 168.99 APE9-dihe-na 122.16, -170.23 APE8-dihe-in -91.66, 136.86 APE8-rot-in 289.24 APE67-dihe-in -72.3, -22.91 -49.4, -40.32 APE12-dist-in 8.3287 APE11-dist-in 11.2559 APE10-dist-in 5.6928 APE9-dist-in 3.7423 None TPO412,TPO564 TPO412,TPO564 XRAY 3.25 0.258 0.284 B 349.0 320.0 20 28 28 0 [[254, 522]] 1.0 5lih AGC_PRKCI_HUMAN AGC 1.1e-95 325.5 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 9EJMB P41743 249 588 596.0 ADP:60601 ATPlike None DFGin 6.2004 12.8648 BLAminus -142.99, -166.55 58.77, 70.37 -95.2, 28.65 312.71, 127.0 -80.74, 2.56 in-none in 9.1664 Saltbr-none 999.0 HRD-in -62.9, -53.16 64.41, -0.47 none-in-in SNCnii in-in ActLoopNT-in 3.1518 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.58, 153.63 APE9-dihe-na 128.65, 169.74 APE8-dihe-in -69.25, 127.47 APE8-rot-in 310.74 APE67-dihe-in -76.65, -32.17 -60.48, -21.91 APE12-dist-in 9.6026 APE11-dist-in 12.2532 APE10-dist-in 6.5946 APE9-dist-in 3.9282 None TPO412,TPO564 TPO412,TPO564 EM 3.33 999.0 999.0 B 596.0 322.0 9 28 28 0 [[254, 522]] 1.0 9ejm AGC_PRKCI_HUMAN AGC 5.2e-95 323.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
CAMK AURKA AURKA_HUMAN 8GUWA O14965 506 388 403.0 ADP:60501 ATPlike Inactive DFGin 5.4961 16.0011 ABAminus -116.4, -50.49 -101.78, 116.28 -108.31, 28.43 281.67, 88.04 -72.88, -24.68 out-out out 11.7793 Saltbr-out 6.9626 HRD-out -52.32, 144.81 -137.03, 32.44 out-in-out SNCoio in-out ActLoopNT-in 2.989 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 154.24 APE8-dihe-in -135.99, 160.18 APE8-rot-out 182.57 APE67-dihe-in -45.22, -30.26 -102.15, -5.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 22.8351 C290A,C393A None None XRAY 2.7 0.216 0.258 A 304.0 259.0 7 26 19 7 [[133, 383]] 1.0 8guw CAMK_AURKA_HUMAN CAMK 1.2e-78 270.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8GUWB O14965 507 390 403.0 ADP:60501 ATPlike Inactive DFGin 5.2903 15.6844 ABAminus -103.46, -56.86 -84.59, 164.71 -149.11, 43.73 280.55, 102.4 -37.77, -51.78 out-out out 11.2219 Saltbr-out 10.1241 HRD-out -88.2, 114.65 -57.32, -35.01 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 120.59 APE8-rot-out 188.97 APE67-dihe-out 79.95, -4.59 -68.08, -173.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C290A,C393A None None XRAY 2.7 0.216 0.258 B 304.0 250.0 13 26 13 13 [[133, 383]] 1.0 8guw CAMK_AURKA_HUMAN CAMK 1.2e-78 270.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8GUWC O14965 506 388 403.0 ADP:60501 ATPlike Inactive DFGin 5.7941 16.123 ABAminus -112.39, -57.42 -66.39, 155.71 -143.31, 23.7 266.43, 102.44 -50.18, -24.58 out-out out 11.5307 Saltbr-out 6.1466 HRD-out -98.37, 113.81 -121.54, 28.92 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -46.16 APE8-rot-in 299.01 APE67-dihe-in -63.17, -8.64 -58.96, -54.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C290A,C393A None None XRAY 2.7 0.216 0.258 C 304.0 248.0 18 26 12 14 [[133, 383]] 1.0 8guw CAMK_AURKA_HUMAN CAMK 1.2e-78 270.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4BN1A O14965 126 388 403.0 ADP:1391 ATPlike Inactive DFGin 5.7586 14.9619 BLAminus -135.76, 176.64 57.4, 85.44 -97.06, 20.67 283.26, 70.95 -48.27, -40.43 in-in in 9.2277 Saltbr-in 2.7169 HRD-in -70.78, -55.66 70.88, -1.02 in-in-out SNCiio in-out ActLoopNT-in 2.8 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na 16.45, -154.0 APE9-dihe-na 66.92, -173.53 APE8-dihe-in -66.46, 155.86 APE8-rot-out 182.79 APE67-dihe-in -44.49, -32.18 -93.83, -6.12 APE12-dist-in 12.1139 APE11-dist-in 8.7308 APE10-dist-out 13.7066 APE9-dist-out 11.1591 V174M TPO287,TPO288 TPO287,TPO288 XRAY 2.499 0.195 0.244 A 285.0 263.0 0 26 26 0 [[133, 383]] 1.0 4bn1 CAMK_AURKA_HUMAN CAMK 7.5e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 1MQ4A O14965 126 388 403.0 ADP:2001 ATPlike Inactive DFGin 5.607 15.2135 BLAminus -132.59, 179.34 62.49, 72.25 -91.07, 21.51 279.91, 70.01 -61.32, -27.71 in-in in 9.0551 Saltbr-in 2.8803 HRD-in -82.66, -49.31 72.48, -1.39 in-in-out SNCiio in-out ActLoopNT-in 2.9232 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -97.21, -164.83 APE9-dihe-na -146.02, -127.82 APE8-dihe-in -61.49, 131.42 APE8-rot-out 178.11 APE67-dihe-in -51.42, -34.84 -86.66, -6.25 APE12-dist-in 7.6815 APE11-dist-in 11.8468 APE10-dist-out 10.5866 APE9-dist-out 9.9776 None None None XRAY 1.9 0.229 0.273 A 272.0 261.0 2 26 24 2 [[133, 383]] 1.0 1mq4 CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 1OL5A O14965 123 388 403.0 ADP:1388 ATPlike Active DFGin 5.5782 15.0961 BLAminus -139.2, -172.08 52.22, 80.16 -90.83, 24.66 282.61, 72.55 -49.87, -44.18 in-in in 9.4508 Saltbr-in 2.9117 HRD-in -63.28, -60.88 73.6, 1.59 in-in-in SNCiii in-in ActLoopNT-in 2.9276 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.42, 162.5 APE9-dihe-na 119.45, -153.19 APE8-dihe-in -110.77, 140.24 APE8-rot-in 313.06 APE67-dihe-in -62.23, -14.3 -43.16, -62.5 APE12-dist-in 8.1744 APE11-dist-in 10.9573 APE10-dist-in 5.2741 APE9-dist-in 3.683 None TPO287,TPO288 TPO287,TPO288 XRAY 2.5 0.194 0.252 A 282.0 266.0 0 26 26 0 [[133, 383]] 1.0 1ol5 CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 1OL7A O14965 127 390 403.0 ADP:531 ATPlike Inactive DFGin 5.4287 15.0428 BLAminus -133.12, -167.56 48.98, 74.14 -88.94, 32.44 285.93, 64.91 -57.61, -36.14 in-in in 9.5058 Saltbr-in 3.0551 HRD-in -75.56, -48.34 63.05, 5.8 in-in-out SNCiio in-out ActLoopNT-in 2.9785 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -104.11, 138.56 APE9-dihe-na 156.93, 143.05 APE8-dihe-in -89.37, 102.83 APE8-rot-out 182.11 APE67-dihe-in -15.17, -56.94 -45.24, -37.82 APE12-dist-in 11.2666 APE11-dist-in 11.2056 APE10-dist-out 10.4649 APE9-dist-out 8.2689 None TPO287,TPO288 TPO287,TPO288 XRAY 2.75 0.257 0.296 A 282.0 264.0 0 26 26 0 [[133, 383]] 1.0 1ol7 CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4DEEA O14965 124 394 403.0 ADP:503 ATPlike Inactive DFGin 5.9771 15.579 BLAminus -131.54, -177.86 61.33, 72.14 -88.35, 17.45 278.56, 69.2 -56.76, -24.29 in-in in 9.2363 Saltbr-in 2.8355 HRD-in -80.53, -51.88 66.61, 1.43 in-in-out SNCiio in-out ActLoopNT-in 2.6858 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -125.87, -53.37 APE9-dihe-na -86.66, -134.63 APE8-dihe-in -80.8, 152.73 APE8-rot-out 187.03 APE67-dihe-in -37.34, -40.8 -92.92, -9.81 APE12-dist-in 12.1076 APE11-dist-in 10.7866 APE10-dist-out 10.7625 APE9-dist-out 10.5323 T287D None None XRAY 2.3 0.213 0.259 A 279.0 271.0 0 26 26 0 [[133, 383]] 1.0 4dee CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5LXMA O14965 126 392 403.0 ADP:60501 ATPlike Active DFGin 5.3906 14.9756 BLAminus -135.45, -179.78 54.7, 80.97 -90.8, 30.12 283.16, 71.51 -72.4, -3.16 in-in in 9.2473 Saltbr-in 2.7237 HRD-in -74.23, -48.55 66.99, 5.01 in-in-in SNCiii in-in ActLoopNT-in 3.1136 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.91, 137.37 APE9-dihe-na 128.62, -150.21 APE8-dihe-in -129.87, 142.81 APE8-rot-in 303.47 APE67-dihe-in -69.71, -10.62 -37.99, -61.07 APE12-dist-in 8.2574 APE11-dist-in 10.6918 APE10-dist-in 5.2126 APE9-dist-in 3.2978 C290A,C393A TPO288 TPO288 XRAY 2.08 0.202 0.243 A 283.0 267.0 0 26 26 0 [[133, 383]] 1.0 5lxm CAMK_AURKA_HUMAN CAMK 9.2e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4CEGA O14965 127 391 403.0 ADP:1392 ATPlike Inactive DFGin 6.3211 15.6655 BLAminus -126.79, -176.42 60.85, 65.85 -88.73, 20.26 276.07, 70.68 -62.71, -30.16 in-in in 8.907 Saltbr-in 2.7521 HRD-in -80.9, -50.34 70.05, 0.74 in-in-out SNCiio in-out ActLoopNT-in 2.8816 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -88.79, -42.25 APE9-dihe-na -103.79, -144.9 APE8-dihe-in -67.83, 148.92 APE8-rot-out 184.96 APE67-dihe-in -49.78, -34.34 -90.88, -2.74 APE12-dist-in 12.0347 APE11-dist-in 10.9906 APE10-dist-out 11.5002 APE9-dist-out 10.933 C290A,C393A TPO288 TPO288 XRAY 2.1 0.202 0.237 A 285.0 265.0 0 26 26 0 [[133, 383]] 1.0 4ceg CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5G1XA O14965 126 389 403.0 ADP:1390 ATPlike Active DFGin 5.3433 15.03 BLAminus -132.86, -170.57 52.68, 76.5 -90.96, 13.96 279.12, 78.43 -59.51, -20.51 in-in in 9.2783 Saltbr-in 2.828 HRD-in -82.61, -50.12 70.7, 5.33 in-in-in SNCiii in-in ActLoopNT-in 2.9632 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.42, -179.26 APE9-dihe-na 65.74, -155.89 APE8-dihe-in -128.23, 121.78 APE8-rot-in 304.75 APE67-dihe-in -61.27, -19.7 -46.07, -47.67 APE12-dist-in 8.2472 APE11-dist-in 10.7994 APE10-dist-in 5.5303 APE9-dist-in 3.699 C290A,C393A TPO288 TPO288 XRAY 1.72 0.177 0.195 A 285.0 264.0 0 26 26 0 [[133, 383]] 1.0 5g1x CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORLA O14965 127 391 403.0 ADP:401,A4W:407 ATPlike,Allosteric Inactive DFGin 7.0659 16.6489 BLAminus -127.84, -172.28 56.81, 60.19 -82.35, 15.9 271.2, 75.61 -63.85, -28.67 in-in in 9.0488 Saltbr-in 2.7502 HRD-in -78.27, -48.5 74.34, -1.48 in-in-out SNCiio in-out ActLoopNT-in 2.9772 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -99.11, -104.69 APE9-dihe-na -74.24, -110.44 APE8-dihe-in -76.15, 148.12 APE8-rot-out 189.45 APE67-dihe-in -56.74, -24.81 -85.95, -8.4 APE12-dist-in 12.0723 APE11-dist-in 10.971 APE10-dist-out 10.3882 APE9-dist-out 11.2888 C290A TPO288 TPO288 XRAY 1.69 0.206 0.238 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orl CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORNA O14965 127 391 403.0 ADP:401,A5E:404 ATPlike,Allosteric Inactive DFGin 5.6718 15.4032 BLAminus -130.34, -174.38 54.92, 79.97 -94.37, 17.54 279.26, 75.58 -55.07, -30.09 in-in in 9.3539 Saltbr-in 2.9285 HRD-in -81.32, -50.86 72.88, 0.4 in-in-out SNCiio in-out ActLoopNT-in 3.025 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -63.8, -59.63 APE9-dihe-na -97.49, -117.04 APE8-dihe-in -91.34, 143.03 APE8-rot-out 191.17 APE67-dihe-in -51.25, -26.05 -82.57, -15.54 APE12-dist-in 12.3855 APE11-dist-in 10.4017 APE10-dist-out 11.4938 APE9-dist-out 11.3568 None TPO288 TPO288 XRAY 2.19 0.203 0.262 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orn CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OROA O14965 127 391 403.0 ADP:401,A5H:404 ATPlike,Allosteric Inactive DFGin 5.6776 15.3373 BLAminus -140.88, -178.26 60.46, 77.77 -94.07, 18.69 277.24, 76.82 -52.63, -39.97 in-in in 9.2726 Saltbr-in 3.0567 HRD-in -74.27, -52.41 74.24, -3.23 in-in-out SNCiio in-out ActLoopNT-in 2.8427 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -87.43, -63.56 APE9-dihe-na -103.72, -111.07 APE8-dihe-in -78.78, 141.92 APE8-rot-out 181.93 APE67-dihe-in -53.21, -24.39 -89.75, -10.63 APE12-dist-in 12.176 APE11-dist-in 10.5588 APE10-dist-out 11.0011 APE9-dist-out 11.5009 None TPO288 TPO288 XRAY 2.12 0.223 0.281 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5oro CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORPA O14965 127 391 403.0 ADP:401,A5K:404 ATPlike,Allosteric Inactive DFGin 5.8123 15.4919 BLAminus -139.84, -179.78 59.55, 79.52 -94.35, 18.72 278.85, 73.24 -45.22, -42.84 in-in in 9.3871 Saltbr-in 2.908 HRD-in -83.1, -49.94 72.65, -1.94 in-in-out SNCiio in-out ActLoopNT-in 3.0344 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -75.76, -64.68 APE9-dihe-na -107.0, -110.58 APE8-dihe-in -81.78, 136.28 APE8-rot-out 180.06 APE67-dihe-in -57.19, -28.31 -85.06, -6.26 APE12-dist-in 12.3511 APE11-dist-in 10.944 APE10-dist-out 10.7661 APE9-dist-out 11.3666 None TPO288 TPO288 XRAY 2.19 0.21 0.273 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orp CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORRA O14965 127 391 403.0 ADP:401,A5Q:404 ATPlike,Allosteric Inactive DFGin 5.6648 15.4968 BLAminus -133.78, -179.48 60.85, 73.72 -91.04, 29.58 281.03, 75.21 -67.99, -25.16 in-in in 9.4213 Saltbr-in 3.055 HRD-in -80.95, -50.87 71.36, -2.01 in-in-out SNCiio in-out ActLoopNT-in 3.0207 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -79.12, -78.89 APE9-dihe-na -94.43, -116.97 APE8-dihe-in -78.43, 147.39 APE8-rot-out 182.93 APE67-dihe-in -56.59, -23.94 -94.11, -3.91 APE12-dist-in 12.2613 APE11-dist-in 11.0201 APE10-dist-out 10.4273 APE9-dist-out 11.0664 None TPO288 TPO288 XRAY 2.09 0.202 0.256 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orr CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORSA O14965 127 391 403.0 ADP:401,A5W:404 ATPlike,Allosteric Inactive DFGin 5.9555 15.6826 BLAminus -133.47, -175.79 56.95, 73.99 -92.77, 17.89 276.34, 75.78 -60.0, -24.97 in-in in 9.1746 Saltbr-in 2.899 HRD-in -79.83, -50.16 70.98, -0.5 in-in-out SNCiio in-out ActLoopNT-in 3.0015 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -90.64, -79.2 APE9-dihe-na -92.74, -115.85 APE8-dihe-in -81.19, 144.15 APE8-rot-out 184.83 APE67-dihe-in -58.67, -28.41 -85.39, -4.34 APE12-dist-in 12.1926 APE11-dist-in 10.9556 APE10-dist-out 10.6259 APE9-dist-out 11.291 None TPO288 TPO288 XRAY 1.98 0.209 0.257 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5ors CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORTA O14965 127 391 403.0 ADP:401,A5Z:406 ATPlike,Allosteric Inactive DFGin 5.9989 15.7538 BLAminus -125.96, -170.73 54.43, 75.09 -90.85, 19.73 277.07, 68.86 -49.78, -34.73 in-in in 9.1957 Saltbr-in 3.0255 HRD-in -79.74, -50.38 68.95, 1.55 in-in-out SNCiio in-out ActLoopNT-in 3.0837 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -85.06, -64.36 APE9-dihe-na -96.27, -115.21 APE8-dihe-in -89.65, 146.92 APE8-rot-out 194.22 APE67-dihe-in -52.62, -22.53 -93.73, -12.57 APE12-dist-in 12.5307 APE11-dist-in 10.9187 APE10-dist-out 10.824 APE9-dist-out 11.0185 None TPO288 TPO288 XRAY 2.56 0.208 0.275 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5ort CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORVA O14965 127 391 403.0 ADP:401,A65:406 ATPlike,Allosteric Inactive DFGin 5.6645 15.44 BLAminus -136.16, -176.05 58.92, 71.82 -89.03, 22.25 278.38, 76.78 -63.69, -25.31 in-in in 9.2454 Saltbr-in 2.8863 HRD-in -82.57, -52.35 73.38, 1.05 in-in-out SNCiio in-out ActLoopNT-in 3.0056 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -75.39, -87.03 APE9-dihe-na -89.16, -112.46 APE8-dihe-in -77.62, 139.73 APE8-rot-out 181.74 APE67-dihe-in -57.59, -25.24 -84.67, -4.17 APE12-dist-in 12.3135 APE11-dist-in 10.8773 APE10-dist-out 10.4209 APE9-dist-out 11.2549 None TPO288 TPO288 XRAY 1.88 0.214 0.268 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orv CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORWA O14965 127 391 403.0 ADP:401,A6E:404 ATPlike,Allosteric Inactive DFGin 5.7064 15.413 BLAminus -131.01, -175.69 56.41, 78.46 -94.05, 21.38 277.67, 78.36 -59.98, -27.55 in-in in 9.316 Saltbr-in 3.0048 HRD-in -84.25, -51.01 70.55, 2.29 in-in-out SNCiio in-out ActLoopNT-in 3.0694 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -84.32, -59.08 APE9-dihe-na -102.85, -110.93 APE8-dihe-in -86.24, 134.05 APE8-rot-out 178.0 APE67-dihe-in -62.04, -25.17 -80.18, -4.89 APE12-dist-in 12.2689 APE11-dist-in 10.8105 APE10-dist-out 10.9798 APE9-dist-out 11.1995 None TPO288 TPO288 XRAY 2.0 0.217 0.27 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orw CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORXA O14965 127 391 403.0 ADP:401,A6H:404 ATPlike,Allosteric Inactive DFGin 5.4831 15.3325 BLAminus -135.37, -175.69 58.5, 74.51 -88.48, 21.31 281.01, 74.45 -55.7, -31.23 in-in in 9.3916 Saltbr-in 2.8871 HRD-in -84.87, -52.92 73.65, 2.44 in-in-out SNCiio in-out ActLoopNT-in 2.9566 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -81.41, -75.31 APE9-dihe-na -97.77, -112.93 APE8-dihe-in -77.56, 136.59 APE8-rot-out 185.81 APE67-dihe-in -60.3, -23.27 -81.45, -7.22 APE12-dist-in 12.2711 APE11-dist-in 10.9764 APE10-dist-out 10.2482 APE9-dist-out 10.9212 None TPO288 TPO288 XRAY 1.88 0.222 0.27 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orx CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORYA O14965 127 391 403.0 ADP:401,AY4:406 ATPlike,Allosteric Inactive DFGin 5.665 15.4321 BLAminus -133.35, -178.83 58.64, 81.27 -98.02, 26.99 280.05, 73.77 -66.34, -26.48 in-in in 9.4129 Saltbr-in 3.0153 HRD-in -83.1, -49.94 67.85, 0.8 in-in-out SNCiio in-out ActLoopNT-in 2.9683 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -85.35, -78.87 APE9-dihe-na -90.27, -119.1 APE8-dihe-in -76.79, 146.69 APE8-rot-out 180.58 APE67-dihe-in -53.43, -25.94 -95.91, -5.0 APE12-dist-in 12.4465 APE11-dist-in 11.0475 APE10-dist-out 10.7427 APE9-dist-out 11.1533 None TPO288 TPO288 XRAY 1.99 0.207 0.265 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5ory CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORZA O14965 127 391 403.0 ADP:401,A6W:407 ATPlike,Allosteric Inactive DFGin 5.6745 15.4067 BLAminus -135.57, -175.22 57.46, 80.66 -98.54, 24.2 276.77, 79.7 -65.5, -21.43 in-in in 9.2536 Saltbr-in 3.1111 HRD-in -80.39, -48.42 71.09, -2.39 in-in-out SNCiio in-out ActLoopNT-in 3.0623 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -82.59, -77.55 APE9-dihe-na -100.89, -113.21 APE8-dihe-in -76.47, 144.8 APE8-rot-out 177.65 APE67-dihe-in -57.19, -24.65 -94.21, -4.24 APE12-dist-in 12.3009 APE11-dist-in 10.8877 APE10-dist-out 10.4018 APE9-dist-out 11.2099 None TPO288 TPO288 XRAY 1.92 0.199 0.244 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orz CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS0A O14965 127 391 403.0 ADP:401,A6Z:404 ATPlike,Allosteric Inactive DFGin 5.6629 15.4407 BLAminus -133.76, -174.78 57.78, 75.99 -91.75, 21.09 277.99, 75.39 -60.35, -28.95 in-in in 9.311 Saltbr-in 2.7878 HRD-in -86.51, -49.56 71.53, 0.91 in-in-out SNCiio in-out ActLoopNT-in 2.9596 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -90.57, -76.63 APE9-dihe-na -103.27, -112.09 APE8-dihe-in -75.93, 143.74 APE8-rot-out 179.33 APE67-dihe-in -59.48, -25.37 -86.69, -3.69 APE12-dist-in 12.1557 APE11-dist-in 10.864 APE10-dist-out 10.2569 APE9-dist-out 11.2043 None TPO288 TPO288 XRAY 1.74 0.22 0.264 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5os0 CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS1A O14965 127 391 403.0 ADP:401,A7H:407 ATPlike,Allosteric Inactive DFGin 5.601 15.3207 BLAminus -135.04, -179.66 61.87, 77.96 -95.19, 22.65 277.87, 73.62 -63.45, -26.73 in-in in 9.2237 Saltbr-in 2.9199 HRD-in -84.64, -47.57 66.67, 4.82 in-in-out SNCiio in-out ActLoopNT-in 3.0164 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -71.95, -77.41 APE9-dihe-na -100.69, -116.41 APE8-dihe-in -72.42, 138.52 APE8-rot-out 177.77 APE67-dihe-in -60.13, -26.29 -83.6, -2.57 APE12-dist-in 12.2392 APE11-dist-in 10.8166 APE10-dist-out 10.5993 APE9-dist-out 11.2579 None TPO288 TPO288 XRAY 1.9 0.203 0.25 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5os1 CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS2A O14965 127 391 403.0 ADP:401,A7K:404 ATPlike,Allosteric Inactive DFGin 5.6983 15.5293 BLAminus -131.21, -175.25 58.7, 76.84 -90.56, 21.45 276.93, 76.69 -62.35, -9.35 in-in in 9.3094 Saltbr-in 2.9759 HRD-in -79.13, -51.53 72.78, 2.45 in-in-out SNCiio in-out ActLoopNT-in 3.0182 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -27.53 APE9-dihe-na -109.52, -133.64 APE8-dihe-in -78.79, 129.87 APE8-rot-out 174.59 APE67-dihe-in -60.88, -25.02 -78.66, -3.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.8302 APE9-dist-out 10.9565 None None None XRAY 1.92 0.213 0.251 A 265.0 261.0 4 26 22 4 [[133, 383]] 1.0 5os2 CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS3A O14965 127 391 403.0 ADP:401,A7N:404 ATPlike,Allosteric Inactive DFGin 5.8534 15.6154 BLAminus -132.65, -178.67 63.71, 72.3 -91.21, 21.81 276.12, 75.45 -58.53, -29.86 in-in in 9.1686 Saltbr-in 2.9283 HRD-in -82.57, -48.69 69.82, -0.73 in-in-out SNCiio in-out ActLoopNT-in 2.9663 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -97.05, -71.52 APE9-dihe-na -103.15, -115.69 APE8-dihe-in -76.83, 145.54 APE8-rot-out 186.8 APE67-dihe-in -55.71, -28.81 -87.14, -3.16 APE12-dist-in 12.1833 APE11-dist-in 10.9495 APE10-dist-out 10.3755 APE9-dist-out 11.239 None TPO288 TPO288 XRAY 1.81 0.203 0.238 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5os3 CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS4A O14965 127 391 403.0 ADP:401,A8H:404 ATPlike,Allosteric Inactive DFGin 5.5617 15.3883 BLAminus -130.51, -177.66 61.48, 75.55 -91.39, 22.5 279.03, 76.09 -60.73, -28.57 in-in in 9.2451 Saltbr-in 2.8621 HRD-in -82.71, -48.02 68.35, 3.92 in-in-out SNCiio in-out ActLoopNT-in 2.9591 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -77.92, -67.81 APE9-dihe-na -96.69, -121.48 APE8-dihe-in -75.57, 137.34 APE8-rot-out 180.49 APE67-dihe-in -57.86, -25.07 -81.82, -5.88 APE12-dist-in 12.2565 APE11-dist-in 10.8031 APE10-dist-out 10.9355 APE9-dist-out 11.2587 None TPO288 TPO288 XRAY 1.88 0.205 0.24 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5os4 CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS6A O14965 127 391 403.0 ADP:401,A7Q:404 ATPlike,Allosteric Inactive DFGin 6.0291 15.7815 BLAminus -126.13, -169.53 51.73, 76.81 -92.36, 19.58 272.42, 79.82 -57.78, -34.45 in-in in 9.2445 Saltbr-in 2.995 HRD-in -81.41, -52.88 69.05, 4.37 in-in-out SNCiio in-out ActLoopNT-in 3.0404 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -77.03, -70.53 APE9-dihe-na -90.32, -115.88 APE8-dihe-in -84.85, 141.6 APE8-rot-out 180.13 APE67-dihe-in -64.32, -26.41 -86.27, 0.74 APE12-dist-in 12.2131 APE11-dist-in 10.8263 APE10-dist-out 10.7401 APE9-dist-out 10.9916 None TPO288 TPO288 XRAY 2.2 0.216 0.277 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5os6 CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OSEA O14965 127 391 403.0 ADP:401,A98:404 ATPlike,Allosteric Inactive DFGin 5.6464 15.4407 BLAminus -134.11, -176.47 59.39, 78.15 -96.43, 21.72 274.12, 77.75 -65.33, -24.45 in-in in 9.1368 Saltbr-in 2.8845 HRD-in -78.93, -49.87 70.59, 0.35 in-in-out SNCiio in-out ActLoopNT-in 2.9592 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -81.25, -72.54 APE9-dihe-na -105.09, -114.94 APE8-dihe-in -73.18, 141.65 APE8-rot-out 184.53 APE67-dihe-in -56.53, -26.26 -88.57, -5.48 APE12-dist-in 12.1504 APE11-dist-in 10.9758 APE10-dist-out 10.508 APE9-dist-out 11.2527 None TPO288 TPO288 XRAY 1.9 0.192 0.237 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5ose CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OSFA O14965 127 391 403.0 ADP:401,A9E:404 ATPlike,Allosteric Inactive DFGin 5.7593 15.6562 BLAminus -131.88, -178.74 65.35, 71.33 -84.84, 21.28 278.92, 73.36 -65.0, -27.04 in-in in 9.3139 Saltbr-in 2.8266 HRD-in -85.08, -46.49 62.7, 8.17 in-in-out SNCiio in-out ActLoopNT-in 2.9651 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -87.68, -61.8 APE9-dihe-na -106.59, -110.06 APE8-dihe-in -85.81, 135.3 APE8-rot-out 180.39 APE67-dihe-in -56.65, -25.75 -79.56, -7.54 APE12-dist-in 12.2037 APE11-dist-in 10.6895 APE10-dist-out 10.9134 APE9-dist-out 11.4534 None TPO288 TPO288 XRAY 1.89 0.204 0.254 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5osf CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OSDA O14965 125 391 403.0 ADP:401,A9B:404 ATPlike,Allosteric Inactive DFGin 5.672 15.4437 BLAminus -133.73, -178.01 59.76, 77.67 -95.6, 25.32 277.59, 73.38 -66.16, -23.93 in-in in 9.1535 Saltbr-in 2.9136 HRD-in -79.03, -50.3 71.01, -1.56 in-in-out SNCiio in-out ActLoopNT-in 3.0371 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -81.55, -62.64 APE9-dihe-na -107.55, -120.42 APE8-dihe-in -75.26, 143.45 APE8-rot-out 177.88 APE67-dihe-in -54.13, -27.04 -91.57, -4.8 APE12-dist-in 12.2502 APE11-dist-in 11.0743 APE10-dist-out 10.8059 APE9-dist-out 11.1972 None TPO288 TPO288 XRAY 1.99 0.198 0.239 A 267.0 267.0 0 26 26 0 [[133, 383]] 1.0 5osd CAMK_AURKA_HUMAN CAMK 7.4e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS5A O14965 125 392 403.0 ADP:401,A8K:404 ATPlike,Allosteric Inactive DFGin 5.536 15.2749 BLAminus -135.35, -174.05 58.1, 79.63 -93.47, 22.72 276.13, 73.04 -64.31, -25.3 in-in in 9.3797 Saltbr-in 2.8681 HRD-in -80.2, -52.69 73.71, 2.64 in-in-out SNCiio in-out ActLoopNT-in 2.8801 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -96.33, -47.43 APE9-dihe-na -104.6, -130.88 APE8-dihe-in -73.88, 139.12 APE8-rot-out 187.09 APE67-dihe-in -61.32, -25.92 -83.14, -4.09 APE12-dist-in 12.2806 APE11-dist-in 10.8451 APE10-dist-out 11.3572 APE9-dist-out 10.9535 None TPO288 TPO288 XRAY 1.74 0.199 0.236 A 268.0 268.0 0 26 26 0 [[133, 383]] 1.0 5os5 CAMK_AURKA_HUMAN CAMK 7.5e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6R49A O14965 127 391 403.0 ADP:501,JSB:504 ATPlike,Allosteric Inactive DFGin 5.6142 15.4571 BLAminus -138.43, -175.42 57.6, 78.22 -94.44, 21.89 276.25, 76.24 -57.77, -33.65 in-in in 9.3806 Saltbr-in 2.8938 HRD-in -87.16, -51.58 76.44, -3.34 in-in-out SNCiio in-out ActLoopNT-in 3.1015 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -122.85 APE8-dihe-in -81.14, 140.15 APE8-rot-out 187.07 APE67-dihe-in -51.76, -30.76 -84.84, -7.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0529 C290A,C393A TPO288 TPO288 XRAY 2.209 0.194 0.24 A 285.0 260.0 5 26 21 5 [[133, 383]] 1.0 6r49 CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6R4AA O14965 127 391 403.0 ADP:501,JRT:510 ATPlike,Allosteric Inactive DFGin 6.1565 15.9493 BLAminus -128.43, -176.18 59.16, 64.31 -84.29, 19.22 274.78, 74.05 -63.59, -28.66 in-in in 9.1016 Saltbr-in 2.8252 HRD-in -85.32, -47.41 69.85, -3.89 in-in-out SNCiio in-out ActLoopNT-in 3.0232 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -103.23, -102.89 APE9-dihe-na -87.4, -108.97 APE8-dihe-in -74.29, 145.29 APE8-rot-out 184.87 APE67-dihe-in -57.97, -25.59 -89.08, -1.69 APE12-dist-in 12.109 APE11-dist-in 10.8679 APE10-dist-out 9.9425 APE9-dist-out 11.4483 C290A,C393A TPO288 TPO288 XRAY 1.937 0.193 0.234 A 285.0 265.0 0 26 26 0 [[133, 383]] 1.0 6r4a CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6R4BA O14965 127 391 403.0 ADP:501,JSN:508 ATPlike,Allosteric Inactive DFGin 5.8943 15.6634 BLAminus -137.57, -177.62 60.57, 72.93 -89.1, 20.04 274.87, 75.15 -57.71, -33.47 in-in in 9.285 Saltbr-in 2.8908 HRD-in -83.52, -48.93 71.64, -3.16 in-in-out SNCiio in-out ActLoopNT-in 2.9599 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -86.33, -81.37 APE9-dihe-na -105.19, -110.27 APE8-dihe-in -73.56, 134.57 APE8-rot-out 182.29 APE67-dihe-in -52.75, -29.28 -80.52, -6.55 APE12-dist-in 12.1859 APE11-dist-in 10.9551 APE10-dist-out 10.1562 APE9-dist-out 11.3762 None TPO288 TPO288 XRAY 2.15 0.191 0.23 A 285.0 265.0 0 26 26 0 [[133, 383]] 1.0 6r4b CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6R4CA O14965 127 391 403.0 ADP:501,JRQ:507 ATPlike,Allosteric Inactive DFGin 6.0205 15.666 BLAminus -134.91, -179.34 60.98, 67.5 -85.83, 17.59 275.41, 71.94 -60.31, -30.9 in-in in 9.0676 Saltbr-in 2.7695 HRD-in -80.73, -51.78 76.01, -7.95 in-in-out SNCiio in-out ActLoopNT-in 2.8911 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -93.37, -96.1 APE9-dihe-na -98.19, -111.55 APE8-dihe-in -67.65, 142.09 APE8-rot-out 185.03 APE67-dihe-in -56.49, -28.95 -89.55, -1.14 APE12-dist-in 12.1917 APE11-dist-in 10.8889 APE10-dist-out 9.9307 APE9-dist-out 11.3954 C290A,C393A TPO288 TPO288 XRAY 2.04 0.188 0.226 A 285.0 265.0 0 26 26 0 [[133, 383]] 1.0 6r4c CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6R4DA O14965 127 391 403.0 ADP:501,JRW:505 ATPlike,Allosteric Inactive DFGin 5.4128 15.0606 BLAminus -136.32, -175.95 60.26, 82.3 -97.39, 21.73 280.16, 71.96 -61.32, -30.02 in-in in 9.3772 Saltbr-in 2.9356 HRD-in -84.35, -49.77 70.9, 2.54 in-in-out SNCiio in-out ActLoopNT-in 2.8984 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -109.88, -49.72 APE9-dihe-na -75.41, -134.11 APE8-dihe-in -89.35, 144.76 APE8-rot-out 181.5 APE67-dihe-in -55.31, -28.98 -80.38, -7.16 APE12-dist-in 12.1691 APE11-dist-in 10.3905 APE10-dist-out 11.4777 APE9-dist-out 10.5886 C290A,C393A TPO288 TPO288 XRAY 2.009 0.197 0.233 A 285.0 265.0 0 26 26 0 [[133, 383]] 1.0 6r4d CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 7ZTLA O14965 126 389 403.0 ADP:501,BCN:506 ATPlike,Allosteric Active DFGin 5.6229 15.1084 BLAminus -131.55, 179.55 58.91, 75.38 -87.97, 22.52 281.42, 69.29 -65.3, -21.25 in-in in 9.2252 Saltbr-in 2.815 HRD-in -81.87, -52.88 75.2, 3.05 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.79, 177.44 APE9-dihe-na 70.08, -157.96 APE8-dihe-in -126.05, 125.84 APE8-rot-in 309.73 APE67-dihe-in -58.88, -23.16 -51.84, -48.56 APE12-dist-in 8.1263 APE11-dist-in 10.6011 APE10-dist-in 5.3541 APE9-dist-in 3.7652 C290A,K339C,C393A TPO288 TPO288 XRAY 1.9 0.165 0.193 A 309.0 264.0 0 26 26 0 [[133, 383]] 1.0 7ztl CAMK_AURKA_HUMAN CAMK 4.2e-78 268.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8OF5A O14965 126 390 403.0 ADP:501,MPO:505 ATPlike,Allosteric Inactive DFGin 5.5613 15.0734 BLAminus -147.6, 177.58 63.9, 71.93 -82.69, 26.74 280.62, 72.05 -50.28, -40.53 in-in in 9.3763 Saltbr-in 2.7388 HRD-in -82.42, -53.84 70.6, 7.86 in-in-out SNCiio in-out ActLoopNT-in 2.9866 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na 65.3, 47.54 APE9-dihe-na -68.67, -176.82 APE8-dihe-in -69.15, 145.4 APE8-rot-out 54.1 APE67-dihe-in -51.26, -26.94 -88.64, -16.45 APE12-dist-out 18.2387 APE11-dist-out 20.5865 APE10-dist-out 23.6119 APE9-dist-out 27.9049 C290A,N332A,Q335A,C393A None None XRAY 1.97 0.186 0.235 A 285.0 265.0 0 26 26 0 [[133, 383]] 1.0 8of5 CAMK_AURKA_HUMAN CAMK 3.1e-78 268.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C14A O14965 126 389 403.0 ADP:417,T5L:418,T0L:424 ATPlike,Allosteric,Allosteric Inactive DFGin 5.6307 14.7937 BLAminus -132.92, -178.64 59.29, 78.11 -87.91, 19.69 280.37, 75.08 -49.0, -40.94 in-in in 9.3228 Saltbr-in 2.7489 HRD-in -74.47, -52.26 68.72, 1.37 in-in-out SNCiio in-out ActLoopNT-in 2.8228 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -125.05, 2.89 APE9-dihe-na -76.04, 173.54 APE8-dihe-in -47.98, 133.45 APE8-rot-in 311.24 APE67-dihe-in -48.21, -32.08 -100.5, -9.07 APE12-dist-in 9.0819 APE11-dist-in 13.0305 APE10-dist-out 15.5933 APE9-dist-out 10.8925 None TPO288 TPO288 XRAY 1.93 0.182 0.194 A 272.0 264.0 0 26 26 0 [[133, 383]] 1.0 8c14 CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C15A O14965 126 388 403.0 ADP:401,T4C:404,T5L:405 ATPlike,Allosteric,Allosteric Inactive DFGin 5.6579 14.941 BLAminus -128.39, 176.76 57.21, 80.94 -90.54, 19.4 280.16, 77.64 -46.89, -42.14 in-in in 9.3562 Saltbr-in 2.9117 HRD-in -70.87, -48.88 65.09, -5.38 in-in-out SNCiio in-out ActLoopNT-in 2.8481 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -170.75 APE8-dihe-in -66.3, 161.07 APE8-rot-out 73.39 APE67-dihe-in -37.43, -35.12 -85.37, -6.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.144 C290A None None XRAY 2.41 0.199 0.207 A 265.0 259.0 4 26 22 4 [[133, 383]] 1.0 8c15 CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1FA O14965 126 388 403.0 ADP:401,T5L:409,T2O:417 ATPlike,Allosteric,Allosteric Inactive DFGin 5.4716 14.6337 BLAminus -130.51, -175.69 56.68, 77.24 -89.7, 19.52 279.6, 79.65 -52.03, -32.93 in-in in 9.3024 Saltbr-in 2.8107 HRD-in -73.98, -48.91 69.8, -1.54 in-in-out SNCiio in-out ActLoopNT-in 2.8765 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -138.04 APE8-dihe-in -67.54, 164.12 APE8-rot-out 77.8 APE67-dihe-in -44.07, -35.33 -85.42, 0.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.5223 C290A None None XRAY 1.924 0.206 0.234 A 265.0 258.0 5 26 21 5 [[133, 383]] 1.0 8c1f CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1IA O14965 126 388 403.0 ADP:401,T1L:404,T5L:405 ATPlike,Allosteric,Allosteric Inactive DFGin 5.5241 14.838 BLAminus -129.39, -179.52 57.08, 78.15 -89.88, 20.87 280.11, 76.95 -51.9, -37.66 in-in in 9.3549 Saltbr-in 2.9056 HRD-in -72.05, -49.31 67.09, -4.7 in-in-out SNCiio in-out ActLoopNT-in 2.8215 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -172.24 APE8-dihe-in -59.73, 161.33 APE8-rot-out 79.24 APE67-dihe-in -39.82, -36.32 -87.05, -1.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.3413 C290A None None XRAY 2.81 0.213 0.234 A 265.0 260.0 3 26 23 3 [[133, 383]] 1.0 8c1i CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1MA O14965 127 389 403.0 T4X:402,ADP:404 Allosteric,ATPlike Inactive DFGin 5.6001 15.2723 BLAminus -122.0, 174.82 64.71, 68.72 -82.42, 30.82 279.23, 73.39 -59.87, -38.7 in-in in 9.6473 Saltbr-in 3.0527 HRD-in -66.75, -51.37 63.02, 9.93 in-in-out SNCiio in-out ActLoopNT-in 2.8953 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -144.61, 52.2 APE9-dihe-na -98.47, -158.53 APE8-dihe-in -77.97, 114.41 APE8-rot-out 83.32 APE67-dihe-in -36.94, -36.23 -77.28, -23.95 APE12-dist-in 9.5276 APE11-dist-in 12.9895 APE10-dist-out 15.7549 APE9-dist-out 10.6188 None TPO288 TPO288 XRAY 2.84 0.253 0.269 A 273.0 263.0 0 26 26 0 [[133, 383]] 1.0 8c1m CAMK_AURKA_HUMAN CAMK 6.5e-80 274.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1DA O14965 127 388 403.0 T2F:401,ADP:402,T5L:405 Allosteric,ATPlike,Allosteric Inactive DFGin 5.5903 14.7701 BLAminus -129.39, 179.64 57.3, 80.97 -92.88, 23.53 280.13, 79.47 -56.16, -33.44 in-in in 9.3061 Saltbr-in 2.9364 HRD-in -72.1, -50.49 67.69, -1.24 in-in-out SNCiio in-out ActLoopNT-in 2.7964 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 144.85 APE8-dihe-in -64.26, 154.27 APE8-rot-out 88.6 APE67-dihe-in -39.49, -36.75 -82.32, -6.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.088 C290A None None XRAY 2.115 0.212 0.238 A 265.0 259.0 3 26 23 3 [[133, 383]] 1.0 8c1d CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1GA O14965 127 388 403.0 T3I:401,ADP:402,T5L:406 Allosteric,ATPlike,Allosteric Inactive DFGin 5.5437 14.882 BLAminus -128.11, -179.39 58.87, 76.11 -85.79, 22.41 279.68, 78.85 -51.87, -42.67 in-in in 9.2229 Saltbr-in 2.92 HRD-in -78.13, -46.93 64.28, -1.01 in-in-out SNCiio in-out ActLoopNT-in 2.8594 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -158.88 APE8-dihe-in -70.7, 159.97 APE8-rot-out 74.34 APE67-dihe-in -36.07, -37.71 -84.84, -3.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.3547 C290A None None XRAY 1.96 0.2 0.225 A 265.0 258.0 4 26 22 4 [[133, 383]] 1.0 8c1g CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1HA O14965 127 388 403.0 T3U:401,ADP:402,T5L:405 Allosteric,ATPlike,Allosteric Inactive DFGin 5.6033 14.806 BLAminus -133.2, 171.3 67.89, 80.13 -90.96, 20.95 279.09, 80.15 -47.86, -43.49 in-in in 9.2738 Saltbr-in 3.0016 HRD-in -69.34, -50.65 67.03, -6.54 in-in-out SNCiio in-out ActLoopNT-in 2.8653 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -157.54 APE8-dihe-in -70.83, 158.42 APE8-rot-out 74.14 APE67-dihe-in -36.91, -39.82 -81.98, -5.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.5277 C290A None None XRAY 2.233 0.213 0.245 A 265.0 258.0 4 26 22 4 [[133, 383]] 1.0 8c1h CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1KA O14965 127 388 403.0 T4O:401,ADP:402,T5L:405 Allosteric,ATPlike,Allosteric Inactive DFGin 5.3967 14.7974 BLAminus -136.92, -175.3 58.28, 79.92 -93.28, 13.0 269.57, 89.35 -50.4, -38.71 in-in in 9.6032 Saltbr-in 3.1142 HRD-in -64.38, -56.58 69.39, -9.24 in-in-out SNCiio in-out ActLoopNT-in 3.0088 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na 39.31, -114.48 APE9-dihe-na 117.85, -67.49 APE8-dihe-in -136.08, 128.66 APE8-rot-out 19.12 APE67-dihe-in -37.03, -29.23 -73.31, -14.52 APE12-dist-in 9.2582 APE11-dist-in 12.9138 APE10-dist-out 12.6881 APE9-dist-out 10.8352 C290A None None XRAY 2.43 0.219 0.242 A 273.0 262.0 0 26 26 0 [[133, 383]] 1.0 8c1k CAMK_AURKA_HUMAN CAMK 8e-79 270.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8PR7D O14965 126 388 403.0 ADP:501 ATPlike Inactive DFGin 6.9163 17.6819 BLBminus -119.47, -172.43 57.55, 67.82 -98.5, 138.77 288.48, 69.88 152.2, -37.73 out-none out 11.7807 Saltbr-none 999.0 HRD-in -89.57, -45.69 63.63, 4.27 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, 178.01 APE9-dihe-na 51.17, 13.86 APE8-dihe-out -88.74, -9.17 APE8-rot-none 999.0 APE67-dihe-in -65.89, -30.04 -136.83, 2.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.9294 APE9-dist-out 11.3958 D274N,C290A,N332A,Q335A,T347A,D350A,C393A None None XRAY 2.76 0.205 0.256 D 283.0 251.0 12 26 14 12 [[133, 383]] 1.0 8pr7 CAMK_AURKA_HUMAN CAMK 3e-77 265.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ODTA O14965 126 392 403.0 ADP:501 ATPlike Inactive DFGin 6.7171 16.9598 None -121.13, 4.47 -111.78, 32.81 -79.52, 164.76 286.94, 96.78 78.48, -128.28 out-out out 11.7478 Saltbr-out 10.767 HRD-out -137.93, 83.59 -73.55, -34.72 out-out-out SNCooo out-out ActLoopNT-out 17.7885 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, -15.28 APE9-dihe-na -98.55, 177.35 APE8-dihe-out 65.78, -46.63 APE8-rot-none 999.0 APE67-dihe-in -47.55, -29.4 -45.89, -32.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 24.8668 APE9-dist-out 13.4366 D274N,C290A,C393A None None XRAY 2.021 0.179 0.211 A 283.0 258.0 9 26 17 9 [[133, 383]] 1.0 5odt CAMK_AURKA_HUMAN CAMK 5.4e-78 267.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 9GUCA O14965 124 391 403.0 ADP:501,AMP:503 ATPlike,Allosteric Inactive DFGin 7.1772 17.543 None -98.47, -53.8 -99.76, 123.69 -123.57, 999.0 272.41, 116.36 999.0, 999.0 out-none out 10.8811 Saltbr-none 999.0 HRD-in -77.17, -58.19 77.29, 1.39 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na -78.2, -27.21 APE9-dihe-na 141.47, -167.5 APE8-dihe-in -95.93, 123.55 APE8-rot-in 299.51 APE67-dihe-in -57.72, -20.14 -51.84, -47.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.7077 C290A,C393A None None XRAY 2.1 0.193 0.232 A 285.0 256.0 12 26 14 12 [[133, 383]] 1.0 9guc CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5L8JA O14965 126 391 403.0 ADP:60501 ATPlike Inactive DFGinter 6.0388 8.8115 None -121.42, -0.81 -92.81, -3.45 60.99, 19.44 297.14, 26.84 -77.84, 60.22 out-out out 13.2014 Saltbr-out 9.5877 HRD-out -100.39, 154.9 -77.66, -154.82 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 16.48 APE8-rot-out 62.75 APE67-dihe-in -57.65, -20.32 -54.21, -40.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C290A,C393A TPO288 TPO288 XRAY 1.68 0.201 0.231 A 285.0 253.0 13 26 13 13 [[133, 383]] 1.0 5l8j CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5L8KA O14965 126 392 403.0 ADP:60501 ATPlike Inactive DFGinter 5.9336 8.6956 None -123.53, 3.87 -94.88, 4.13 51.12, 25.43 307.6, 8.65 -83.23, 69.32 out-out out 12.9065 Saltbr-out 9.1369 HRD-out -94.24, 154.96 -82.75, -161.39 out-out-out SNCooo out-out ActLoopNT-out 5.2619 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -60.54, 152.13 APE9-dihe-na 121.57, -104.82 APE8-dihe-in -138.45, 120.03 APE8-rot-in 300.38 APE67-dihe-in -56.47, -22.96 -75.46, -21.38 APE12-dist-out 14.1901 APE11-dist-out 17.8848 APE10-dist-out 19.7221 APE9-dist-out 13.7291 C290A,C393A TPO288 TPO288 XRAY 1.79 0.192 0.235 A 285.0 267.0 0 26 26 0 [[133, 383]] 1.0 5l8k CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5L8LA O14965 126 389 403.0 ADP:60501 ATPlike Inactive DFGinter 5.6468 8.8822 None -117.8, 6.57 -92.89, -1.12 53.22, 20.44 289.58, 36.26 -84.0, 68.46 out-out out 12.5405 Saltbr-out 9.0265 HRD-out -99.09, 148.91 -94.35, -164.8 out-out-out SNCooo out-out ActLoopNT-out 5.3927 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -75.26, -165.41 APE9-dihe-na -67.89, -63.26 APE8-dihe-out -124.39, -179.64 APE8-rot-out 64.28 APE67-dihe-in -57.8, -26.84 -83.02, -0.31 APE12-dist-in 11.1091 APE11-dist-out 16.5204 APE10-dist-out 14.4907 APE9-dist-out 14.6386 C290A,C393A TPO288 TPO288 XRAY 1.67 0.193 0.223 A 285.0 264.0 0 26 26 0 [[133, 383]] 1.0 5l8l CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8PR7A O14965 124 389 403.0 ADP:501 ATPlike Inactive DFGinter 5.0698 10.2727 None -105.95, 148.75 -124.79, 28.7 -129.06, 999.0 303.51, 120.23 999.0, 999.0 out-out out 12.4819 Saltbr-out 11.7057 HRD-out 52.78, 71.6 -97.43, 142.22 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 47.95, -115.05 APE9-dihe-na -125.01, 9.37 APE8-dihe-out -40.29, -50.01 APE8-rot-out 85.86 APE67-dihe-in -55.11, -34.07 -62.49, -38.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.8319 D274N,C290A,N332A,Q335A,T347A,D350A,C393A None None XRAY 2.76 0.205 0.256 A 283.0 253.0 13 26 13 13 [[133, 383]] 1.0 8pr7 CAMK_AURKA_HUMAN CAMK 3e-77 265.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2WQEA O14965 127 388 403.0 ADP:1389,ADP:1390,ADP:1391 ATPlike,ATPlike,ATPlike Inactive None 999.0 999.0 None -107.12, -44.35 28.24, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 12.4276 Saltbr-none 999.0 HRD-out -82.99, 160.23 -97.32, -44.1 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -56.47 APE8-dihe-out -79.62, -22.51 APE8-rot-in 267.0 APE67-dihe-in -40.62, -26.16 -46.48, -55.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.7962 S155R None None XRAY 2.5 0.206 0.251 A 262.0 241.0 21 26 10 16 [[133, 383]] 1.0 2wqe CAMK_AURKA_HUMAN CAMK 9.7e-80 273.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK CAMK2A KCC2A_HUMAN 7UJSA Q9UQM7 7 274 478.0 ADP:301 ATPlike Active DFGin 6.2091 15.1635 BLAminus -142.86, -173.92 52.2, 80.06 -100.62, 24.47 291.74, 81.6 -63.11, -26.23 in-in in 9.5125 Saltbr-in 3.4437 HRD-in -76.47, -52.69 80.52, -7.0 in-in-in SNCiii in-in ActLoopNT-in 2.9518 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.88, 140.41 APE9-dihe-na 133.49, -148.09 APE8-dihe-in -128.43, 117.33 APE8-rot-in 305.05 APE67-dihe-in -59.07, -26.67 -36.29, -54.08 APE12-dist-in 10.1975 APE11-dist-in 11.5048 APE10-dist-in 5.7786 APE9-dist-in 3.6826 Q223K None None XRAY 2.75 0.201 0.262 A 268.0 268.0 0 28 28 0 [[13, 271]] 1.0 7ujs CAMK_CAMK2A_HUMAN CAMK 1e-96 329.1 1.0 256.0 256.0 155 156 157 159 161 42 60 64 132 134 133 135.0 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 7UJPA Q9UQM7 7 274 478.0 ADP:301 ATPlike Active DFGin 6.7748 14.6398 BLAminus -129.88, 174.11 65.35, 73.67 -96.28, 29.41 284.7, 81.79 -65.3, -26.47 in-in in 8.5267 Saltbr-in 2.9028 HRD-in -76.38, -51.72 77.74, -11.0 in-in-in SNCiii in-in ActLoopNT-in 2.8754 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.94, 142.69 APE9-dihe-na 139.08, -169.53 APE8-dihe-in -115.65, 123.25 APE8-rot-in 308.77 APE67-dihe-in -69.44, -15.11 -33.38, -56.34 APE12-dist-in 10.4685 APE11-dist-in 11.3966 APE10-dist-in 5.657 APE9-dist-in 3.521 D135N,Q223K None None XRAY 2.56 0.234 0.281 A 268.0 268.0 0 28 28 0 [[13, 271]] 1.0 7ujp CAMK_CAMK2A_HUMAN CAMK 9.3e-96 326.0 1.0 256.0 256.0 155 156 157 159 161 42 60 64 132 134 133 135.0 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CHEK2 CHK2_HUMAN 2CN5A O96017 209 504 543.0 ADP:61509 ATPlike Inactive DFGin 6.789 14.4943 BLAminus -135.2, 179.16 64.2, 79.37 -102.1, 20.75 283.06, 77.6 -58.46, -25.36 in-out in 9.9172 Saltbr-out 4.3439 HRD-in -79.96, -48.23 69.59, 1.14 out-in-out SNCoio in-out ActLoopNT-in 2.8477 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -76.74, 7.44 APE9-dihe-na -76.93, 179.76 APE8-dihe-out 76.66, 47.76 APE8-rot-out 216.78 APE67-dihe-in -44.78, -36.74 -82.05, -7.37 APE12-dist-out 25.3627 APE11-dist-out 27.5187 APE10-dist-out 29.8721 APE9-dist-out 32.7677 None None None XRAY 2.25 0.201 0.24 A 329.0 282.0 14 27 27 0 [[220, 486]] 1.0 2cn5 CAMK_CHEK2_HUMAN CAMK 2.1e-85 292.1 1.0 256.0 256.0 367 368 369 371 373 249 273 277 344 346 345 347.0 409 394 389 388 387 386 385 384 383 302 Serine/threonine-protein kinase Chk2
CAMK DAPK1 DAPK1_HUMAN 2W4JA P53355 2 277 1430.0 ADP:1278 ATPlike Inactive DFGin 6.5864 13.8954 BLAminus -123.3, -175.29 63.17, 81.91 -95.29, 20.87 287.95, 79.94 -69.92, -15.2 in-in in 8.9915 Saltbr-in 2.7449 HRD-in -74.79, -47.39 66.71, 11.49 in-in-out SNCiio in-out ActLoopNT-in 2.9313 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -155.28, 112.88 APE9-dihe-na -96.93, -134.15 APE8-dihe-in -90.19, 126.44 APE8-rot-in 297.68 APE67-dihe-in -65.36, -18.9 -46.88, -44.63 APE12-dist-in 10.3574 APE11-dist-out 6.5388 APE10-dist-out 9.6648 APE9-dist-in 4.9924 None None None XRAY 1.3 0.132 0.159 A 277.0 276.0 0 27 27 0 [[13, 275]] 1.0 2w4j CAMK_DAPK1_HUMAN CAMK 4.9e-95 323.6 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3EH9A P53355 2 277 1430.0 ADP:60001 ATPlike Inactive DFGin 6.7195 14.1062 BLAminus -121.08, 178.11 65.97, 83.53 -97.47, 22.9 284.12, 79.86 -68.8, -21.44 in-in in 9.5147 Saltbr-in 3.0884 HRD-in -77.18, -44.06 68.03, 9.36 in-in-out SNCiio in-out ActLoopNT-in 2.8993 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -93.65, 114.44 APE9-dihe-na -90.95, -143.91 APE8-dihe-in -83.41, 125.11 APE8-rot-in 299.02 APE67-dihe-in -61.0, -22.55 -46.4, -40.51 APE12-dist-in 11.1774 APE11-dist-out 5.7723 APE10-dist-out 9.4565 APE9-dist-in 4.5563 None None None XRAY 1.7 0.18 0.217 A 294.0 274.0 2 27 27 0 [[13, 275]] 1.0 3eh9 CAMK_DAPK1_HUMAN CAMK 6.1e-95 323.3 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3F5GA P53355 2 277 1430.0 ADP:60001 ATPlike Inactive DFGin 6.6849 13.9682 BLAminus -120.45, 179.24 65.08, 83.1 -97.05, 24.31 287.76, 77.76 -68.45, -21.11 in-in in 9.307 Saltbr-in 2.7967 HRD-in -76.76, -45.85 68.91, 8.76 in-in-out SNCiio in-out ActLoopNT-in 2.914 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -92.45, 115.11 APE9-dihe-na -89.86, -138.22 APE8-dihe-in -85.51, 124.34 APE8-rot-in 301.38 APE67-dihe-in -61.82, -27.25 -45.2, -42.29 APE12-dist-in 11.0239 APE11-dist-out 5.7744 APE10-dist-out 9.48 APE9-dist-in 4.6227 None None None XRAY 1.85 0.188 0.244 A 294.0 276.0 0 27 27 0 [[13, 275]] 1.0 3f5g CAMK_DAPK1_HUMAN CAMK 6.1e-95 323.3 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 2W4KA P53355 2 302 1430.0 ADP:1303 ATPlike Active DFGin 6.672 14.1782 BLAminus -119.76, -176.11 66.35, 79.87 -97.37, 22.41 282.66, 74.96 -63.58, -22.08 in-in in 9.1099 Saltbr-in 2.8291 HRD-in -72.34, -46.15 68.63, 4.94 in-in-in SNCiii in-in ActLoopNT-in 2.8661 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.51, 175.21 APE9-dihe-na 86.37, -178.83 APE8-dihe-in -92.32, 120.41 APE8-rot-in 301.2 APE67-dihe-in -65.94, -16.49 -43.92, -47.7 APE12-dist-in 9.2041 APE11-dist-in 12.2877 APE10-dist-in 6.8203 APE9-dist-in 5.1317 None None None XRAY 1.9 0.195 0.228 A 302.0 301.0 0 27 27 0 [[13, 275]] 1.0 2w4k CAMK_DAPK1_HUMAN CAMK 6.8e-95 323.2 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3GU6A P53355 2 277 1430.0 ADP:60296 ATPlike Inactive DFGin 6.703 14.0148 BLAminus -123.16, -179.19 61.96, 78.37 -92.65, 24.29 287.26, 76.41 -68.7, -18.31 in-in in 9.0833 Saltbr-in 2.7221 HRD-in -78.16, -47.73 70.74, 4.81 in-in-out SNCiio in-out ActLoopNT-in 2.9167 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -153.98, 117.17 APE9-dihe-na -91.62, -149.81 APE8-dihe-in -81.71, 126.34 APE8-rot-in 293.82 APE67-dihe-in -55.19, -26.27 -45.69, -42.2 APE12-dist-in 10.0084 APE11-dist-out 6.6006 APE10-dist-out 9.4175 APE9-dist-in 4.349 Q23V None None XRAY 1.49 0.185 0.213 A 295.0 276.0 0 27 27 0 [[13, 275]] 1.0 3gu6 CAMK_DAPK1_HUMAN CAMK 2.1e-94 321.5 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3GU7A P53355 2 277 1430.0 ADP:60296 ATPlike Inactive DFGin 6.697 14.1214 BLAminus -119.64, -175.75 62.96, 82.16 -94.9, 24.89 284.57, 77.57 -70.06, -20.41 in-in in 9.2485 Saltbr-in 2.7866 HRD-in -79.97, -44.14 64.75, 4.23 in-in-out SNCiio in-out ActLoopNT-in 2.943 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -162.1, 115.0 APE9-dihe-na -94.82, -140.46 APE8-dihe-in -83.81, 124.48 APE8-rot-in 298.21 APE67-dihe-in -60.5, -27.71 -46.69, -42.88 APE12-dist-in 11.1998 APE11-dist-out 6.3832 APE10-dist-out 9.4382 APE9-dist-in 4.626 Q23V None None XRAY 1.9 0.173 0.228 A 295.0 276.0 0 27 27 0 [[13, 275]] 1.0 3gu7 CAMK_DAPK1_HUMAN CAMK 2.1e-94 321.5 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 2XUUA P53355 2 302 1430.0 ADP:1303 ATPlike Active DFGin 6.8137 14.2995 BLAminus -117.01, 179.93 67.97, 81.82 -97.7, 27.63 286.42, 73.81 -75.99, -13.96 in-in in 9.0474 Saltbr-in 2.6227 HRD-in -76.48, -45.49 71.86, 3.84 in-in-in SNCiii in-in ActLoopNT-in 2.8741 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -168.39, 167.91 APE9-dihe-na 89.82, 178.63 APE8-dihe-in -101.18, 124.0 APE8-rot-in 296.23 APE67-dihe-in -60.21, -22.55 -44.54, -47.64 APE12-dist-in 8.87 APE11-dist-in 11.7269 APE10-dist-in 6.4064 APE9-dist-in 5.145 E182A None None XRAY 1.8 0.179 0.226 A 334.0 301.0 0 27 27 0 [[13, 275]] 1.0 2xuu CAMK_DAPK1_HUMAN CAMK 1.4e-94 322.3 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK MAPKAPK2 MAPK2_HUMAN 1NY3A P49137 46 345 400.0 ADP:401 ATPlike Inactive DFGin 4.2134 13.9181 BLAminus -139.11, 173.49 82.65, 112.5 -121.18, 20.23 280.18, 65.28 -53.92, -18.87 out-out out 10.0385 Saltbr-out 6.1056 HRD-in -63.84, -48.41 55.55, 34.09 out-in-none SNCoin in-none ActLoopNT-in 2.9814 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -47.32, -19.47 999.0, 98.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.27 0.292 A 400.0 277.0 23 27 18 9 [[63, 325]] 1.0 1ny3 CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3.0 256.0 254.0 206 207 208 210 212 93 104 108 183 185 184 186.0 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK PASK PASK_HUMAN 3DLSA Q96RG2 982 1266 1323.0 ADP:1 ATPlike Active DFGin 6.0012 14.2045 BLAminus -129.0, 178.94 63.52, 79.16 -100.96, 27.03 282.44, 72.76 -70.92, -15.42 in-in in 8.6547 Saltbr-in 2.6046 HRD-naE -71.55, -40.2 72.7, 1.22 in-in-in SNCiii in-in ActLoopNT-in 2.9929 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.6, 5.88 APE9-dihe-na -96.65, -154.85 APE8-dihe-in -98.92, 122.93 APE8-rot-in 302.12 APE67-dihe-in -72.66, -14.95 -65.45, -19.89 APE12-dist-in 10.2025 APE11-dist-in 10.5743 APE10-dist-in 5.0607 APE9-dist-in 3.4509 None None None XRAY 2.3 0.244 0.297 A 335.0 285.0 0 27 27 0 [[999, 1251]] 1.0 3dls CAMK_PASK_HUMAN CAMK 2.7e-67 232.8 1.0 256.0 256.0 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128.0 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN 3DLSB Q96RG2 982 1267 1323.0 ADP:2 ATPlike Active DFGin 6.1002 14.0868 BLAminus -126.55, 179.43 61.31, 80.64 -98.16, 22.24 284.4, 71.69 -72.83, -6.95 in-in in 8.3458 Saltbr-in 2.6768 HRD-naE -67.25, -43.38 72.94, 0.56 in-in-in SNCiii in-in ActLoopNT-in 2.9211 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.86, 22.09 APE9-dihe-na -121.63, -155.86 APE8-dihe-in -97.56, 124.97 APE8-rot-in 306.83 APE67-dihe-in -68.7, -17.81 -61.84, -27.67 APE12-dist-in 10.243 APE11-dist-in 10.6876 APE10-dist-in 5.1494 APE9-dist-in 3.5208 None None None XRAY 2.3 0.244 0.297 B 335.0 280.0 6 27 27 0 [[999, 1251]] 1.0 3dls CAMK_PASK_HUMAN CAMK 2.7e-67 232.8 1.0 256.0 256.0 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128.0 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN 3DLSC Q96RG2 982 1267 1323.0 ADP:3 ATPlike Active DFGin 6.5494 14.1362 BLAminus -121.24, -178.98 61.8, 81.93 -100.03, 24.34 279.06, 77.86 -70.4, -24.84 in-in in 8.2856 Saltbr-in 2.707 HRD-naE -75.53, -39.96 73.3, -0.15 in-in-in SNCiii in-in ActLoopNT-in 2.8084 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -109.16, 23.96 APE9-dihe-na -111.98, -161.37 APE8-dihe-in -95.46, 124.23 APE8-rot-in 302.16 APE67-dihe-in -72.29, -18.02 -57.94, -30.36 APE12-dist-in 9.9796 APE11-dist-in 10.4372 APE10-dist-in 4.9616 APE9-dist-in 3.4664 None None None XRAY 2.3 0.244 0.297 C 335.0 281.0 5 27 27 0 [[999, 1251]] 1.0 3dls CAMK_PASK_HUMAN CAMK 2.7e-67 232.8 1.0 256.0 256.0 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128.0 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN 3DLSD Q96RG2 982 1266 1323.0 ADP:4 ATPlike Active DFGin 5.9889 14.0366 BLAminus -119.78, -174.43 57.15, 82.44 -96.61, 20.08 283.36, 68.59 -63.18, -13.75 in-in in 8.5958 Saltbr-in 2.6735 HRD-naE -66.59, -43.13 75.45, -3.58 in-in-in SNCiii in-in ActLoopNT-in 2.8117 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.17, 8.76 APE9-dihe-na -100.36, -154.44 APE8-dihe-in -94.34, 129.8 APE8-rot-in 309.84 APE67-dihe-in -63.24, -17.05 -59.73, -34.41 APE12-dist-in 10.5787 APE11-dist-in 10.6015 APE10-dist-in 5.2119 APE9-dist-in 3.3182 None None None XRAY 2.3 0.244 0.297 D 335.0 284.0 1 27 27 0 [[999, 1251]] 1.0 3dls CAMK_PASK_HUMAN CAMK 2.7e-67 232.8 1.0 256.0 256.0 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128.0 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN 3DLSE Q96RG2 982 1267 1323.0 ADP:5 ATPlike Active DFGin 6.3512 14.1127 BLAminus -115.03, 172.38 61.43, 82.92 -98.38, 26.76 287.19, 66.36 -61.94, -22.57 in-in in 8.272 Saltbr-in 3.0153 HRD-naE -64.64, -41.08 75.56, -14.47 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.8, 6.63 APE9-dihe-na -93.38, -160.98 APE8-dihe-in -92.63, 131.98 APE8-rot-in 304.09 APE67-dihe-in -71.09, -14.17 -58.49, -32.88 APE12-dist-in 10.767 APE11-dist-in 10.575 APE10-dist-in 5.0724 APE9-dist-in 3.4232 None None None XRAY 2.3 0.244 0.297 E 335.0 282.0 4 27 27 0 [[999, 1251]] 1.0 3dls CAMK_PASK_HUMAN CAMK 2.7e-67 232.8 1.0 256.0 256.0 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128.0 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN 3DLSF Q96RG2 982 1266 1323.0 ADP:6 ATPlike Active DFGin 6.2081 14.428 BLAminus -120.86, -179.45 54.8, 74.61 -87.61, 27.75 280.29, 66.66 -72.72, -14.22 in-in in 8.4923 Saltbr-in 2.8794 HRD-naE -64.59, -48.9 86.1, -8.79 in-in-in SNCiii in-in ActLoopNT-in 2.7043 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.3, 4.74 APE9-dihe-na -89.15, -152.34 APE8-dihe-in -104.88, 132.7 APE8-rot-in 302.97 APE67-dihe-in -72.03, -17.52 -62.59, -27.45 APE12-dist-in 10.486 APE11-dist-in 10.5471 APE10-dist-in 5.1005 APE9-dist-in 3.2843 None None None XRAY 2.3 0.244 0.297 F 335.0 281.0 4 27 27 0 [[999, 1251]] 1.0 3dls CAMK_PASK_HUMAN CAMK 2.7e-67 232.8 1.0 256.0 256.0 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128.0 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK STK17B ST17B_HUMAN 6QF4A O94768 18 308 372.0 ADP:405 ATPlike Inactive DFGin 6.2517 14.5888 BLAminus -138.0, 178.42 64.68, 88.16 -110.19, 27.69 285.51, 77.31 -64.42, -20.01 out-out out 10.2932 Saltbr-out 4.3956 HRD-in -72.0, -51.78 71.09, 16.02 out-in-out SNCoio in-out ActLoopNT-in 3.1294 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioo APE10-dihe-na -151.1, 167.46 APE9-dihe-na 109.33, 178.09 APE8-dihe-in -61.1, 118.93 APE8-rot-in 322.5 APE67-dihe-in -69.8, -8.25 -54.96, -33.39 APE12-dist-none 999.0 APE11-dist-in 12.911 APE10-dist-out 10.081 APE9-dist-out 7.8387 None None None XRAY 2.495 0.187 0.227 A 327.0 287.0 4 27 23 4 [[32, 293]] 1.0 6qf4 CAMK_STK17B_HUMAN CAMK 1.4e-81 279.8 4.0 256.0 253.0 178 179 180 182 184 62 80 84 155 157 156 158.0 217 205 200 199 198 197 196 195 194 111 Serine/threonine-protein kinase 17B
CAMK STK17B ST17B_HUMAN 7Q7CA O94768 25 297 372.0 ADP:60402 ATPlike None DFGin 5.6722 13.9829 BLAminus -146.28, 174.77 69.66, 80.54 -103.01, 24.61 291.62, 86.01 -65.04, -13.43 in-in in 9.403 Saltbr-in 3.3501 HRD-in -84.64, -49.74 76.32, -16.47 in-in-none SNCiin in-none ActLoopNT-in 3.2975 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 143.13 APE8-rot-in 309.53 APE67-dihe-in -65.37, -16.14 -54.33, -43.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.85 0.21 0.238 A 327.0 265.0 8 27 19 8 [[32, 293]] 1.0 7q7c CAMK_STK17B_HUMAN CAMK 1.4e-81 279.8 4.0 256.0 253.0 178 179 180 182 184 62 80 84 155 157 156 158.0 217 205 200 199 198 197 196 195 194 111 Serine/threonine-protein kinase 17B
CK1 CSNK1D KC1D_HUMAN 6RU7A P48730 3 294 415.0 ADP:60301 Type1.5_Back Active DFGin 6.392 15.1253 BLAminus -134.23, -173.24 59.44, 80.86 -96.06, 22.96 285.76, 78.27 -62.92, -27.34 in-in in 7.9707 Saltbr-in 2.803 HRD-in -82.18, -50.23 72.61, 5.15 in-in-in SNCiii in-in ActLoopNT-in 2.8844 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.24, 126.6 APE9-dihe-na 114.96, -145.11 APE8-dihe-in -115.28, 122.22 APE8-rot-in 302.31 APE67-dihe-in -56.73, -38.36 -50.64, -46.9 APE12-dist-in 12.3807 APE11-dist-in 12.1789 APE10-dist-in 6.8342 APE9-dist-in 3.5112 None None None XRAY 2.08 0.177 0.218 A 296.0 292.0 0 35 35 0 [[9, 275]] 1.0 6ru7 CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1.0 262.0 262.0 148 149 150 152 154 38 52 56 125 127 126 128.0 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RU7B P48730 3 294 415.0 ADP:60301 Type1.5_Back Active DFGin 6.6176 14.988 BLAminus -130.01, -176.4 60.72, 81.81 -97.28, 21.17 286.1, 78.89 -61.41, -29.58 in-in in 7.7948 Saltbr-in 2.9121 HRD-in -81.31, -50.84 72.75, 6.38 in-in-in SNCiii in-in ActLoopNT-in 2.8782 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.97, 131.36 APE9-dihe-na 113.79, -145.67 APE8-dihe-in -115.43, 125.17 APE8-rot-in 305.08 APE67-dihe-in -54.67, -36.6 -52.93, -49.24 APE12-dist-in 13.2966 APE11-dist-in 12.1561 APE10-dist-in 6.6485 APE9-dist-in 3.5273 None None None XRAY 2.08 0.177 0.218 B 296.0 288.0 4 35 31 4 [[9, 275]] 1.0 6ru7 CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1.0 262.0 262.0 148 149 150 152 154 38 52 56 125 127 126 128.0 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RU8A P48730 2 294 415.0 ADP:60301 Type1.5_Back Active DFGin 6.4247 15.1564 BLAminus -131.62, -177.15 63.45, 81.35 -98.16, 25.89 286.32, 78.16 -68.14, -23.3 in-in in 7.9265 Saltbr-in 2.8026 HRD-in -87.78, -47.56 70.02, 4.06 in-in-in SNCiii in-in ActLoopNT-in 2.84 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.49, 136.29 APE9-dihe-na 109.45, -154.85 APE8-dihe-in -109.19, 121.34 APE8-rot-in 302.42 APE67-dihe-in -58.68, -38.47 -55.68, -42.0 APE12-dist-in 13.5633 APE11-dist-in 12.2822 APE10-dist-in 6.892 APE9-dist-in 3.5723 None None None XRAY 1.92 0.174 0.211 A 296.0 293.0 0 35 35 0 [[9, 275]] 1.0 6ru8 CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1.0 262.0 262.0 148 149 150 152 154 38 52 56 125 127 126 128.0 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RU8B P48730 2 294 415.0 ADP:60301 Type1.5_Back Active DFGin 6.5914 15.2638 BLAminus -131.67, -177.68 64.26, 82.5 -98.0, 23.89 285.39, 79.53 -66.54, -22.27 in-in in 7.6625 Saltbr-in 2.7797 HRD-in -88.75, -48.7 67.58, 11.08 in-in-in SNCiii in-in ActLoopNT-in 2.8535 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.47, 142.8 APE9-dihe-na 95.33, -164.73 APE8-dihe-in -102.94, 120.03 APE8-rot-in 301.71 APE67-dihe-in -59.39, -37.33 -59.11, -40.45 APE12-dist-in 12.3078 APE11-dist-in 12.2946 APE10-dist-in 7.2451 APE9-dist-in 3.8917 None None None XRAY 1.92 0.174 0.211 B 296.0 293.0 0 35 35 0 [[9, 275]] 1.0 6ru8 CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1.0 262.0 262.0 148 149 150 152 154 38 52 56 125 127 126 128.0 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RU8C P48730 2 294 415.0 ADP:60301 Type1.5_Back Active DFGin 6.5578 14.9826 BLAminus -128.29, -179.37 66.68, 80.46 -98.0, 22.92 288.66, 76.31 -64.33, -23.77 in-in in 7.9484 Saltbr-in 2.77 HRD-in -82.99, -49.18 72.75, 4.46 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.59, 138.55 APE9-dihe-na 101.61, -152.03 APE8-dihe-in -108.82, 122.86 APE8-rot-in 298.47 APE67-dihe-in -58.74, -36.85 -58.82, -40.4 APE12-dist-in 13.0395 APE11-dist-in 12.4355 APE10-dist-in 6.8683 APE9-dist-in 3.6074 None None None XRAY 1.92 0.174 0.211 C 296.0 287.0 6 35 29 6 [[9, 275]] 1.0 6ru8 CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1.0 262.0 262.0 148 149 150 152 154 38 52 56 125 127 126 128.0 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RU8D P48730 2 294 415.0 ADP:60301 Type1.5_Back Active DFGin 6.534 14.975 BLAminus -126.38, -177.59 65.46, 80.95 -97.97, 21.9 288.13, 75.77 -63.86, -25.32 in-in in 7.9785 Saltbr-in 2.7823 HRD-in -86.34, -48.63 71.97, 3.09 in-in-in SNCiii in-in ActLoopNT-in 2.8104 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.34, 138.88 APE9-dihe-na 102.71, -155.7 APE8-dihe-in -106.76, 124.41 APE8-rot-in 298.22 APE67-dihe-in -58.88, -36.36 -58.72, -41.76 APE12-dist-in 12.7166 APE11-dist-in 12.3523 APE10-dist-in 6.7426 APE9-dist-in 3.5902 None None None XRAY 1.92 0.174 0.211 D 296.0 293.0 0 35 35 0 [[9, 275]] 1.0 6ru8 CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1.0 262.0 262.0 148 149 150 152 154 38 52 56 125 127 126 128.0 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 TTBK1 TTBK1_HUMAN 4BTJA Q5TCY1 21 312 1321.0 ADP:61337 ATPlike Active DFGin 5.5128 12.6986 BLAminus -122.16, 167.53 65.74, 92.18 -107.62, 12.94 309.85, 113.04 -64.35, -28.29 in-in in 7.1274 Saltbr-in 2.7571 HRD-in -79.44, -52.71 73.3, -5.89 in-in-in SNCiii in-in ActLoopNT-in 2.8215 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.78, 143.11 APE9-dihe-na 98.14, -168.76 APE8-dihe-in -84.14, 153.12 APE8-rot-in 322.08 APE67-dihe-in -60.57, -38.77 -75.21, -43.81 APE12-dist-in 11.388 APE11-dist-in 11.4495 APE10-dist-in 5.9453 APE9-dist-in 3.4123 None None None XRAY 2.16 0.179 0.197 A 337.0 292.0 0 34 34 0 [[34, 295]] 1.0 4btj CK1_TTBK1_HUMAN CK1 5.7e-105 356.4 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
CK1 TTBK2 TTBK2_HUMAN 6VRFA Q6IQ55 9 298 1244.0 ADP:301 ATPlike Active DFGin 5.3543 13.1161 BLAminus -121.29, 164.21 73.75, 82.24 -97.72, 13.38 304.67, 116.94 -64.06, -29.66 in-in in 7.2137 Saltbr-in 2.7506 HRD-in -77.1, -49.95 73.69, -4.56 in-in-in SNCiii in-in ActLoopNT-in 2.8129 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.12, -30.06 APE9-dihe-na -84.65, -146.34 APE8-dihe-in -107.58, 129.44 APE8-rot-in 302.21 APE67-dihe-in -59.13, -37.2 -56.28, -42.66 APE12-dist-in 11.1967 APE11-dist-in 11.3871 APE10-dist-in 5.4802 APE9-dist-in 3.7845 None None None XRAY 1.5 0.175 0.209 A 299.0 287.0 3 34 34 0 [[21, 282]] 1.0 6vrf CK1_TTBK2_HUMAN CK1 7.7e-104 352.6 1.0 262.0 262.0 162 163 164 166 168 50 64 68 138 140 139 141.0 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2
CK1 TTBK2 TTBK2_HUMAN 6VRFB Q6IQ55 9 298 1244.0 ADP:301 ATPlike Active DFGin 5.4311 12.6951 BLAminus -121.38, 163.64 74.07, 85.5 -102.64, 12.86 306.76, 116.33 -62.94, -32.7 in-in in 7.3455 Saltbr-in 2.8906 HRD-in -78.31, -51.54 73.55, 1.77 in-in-in SNCiii in-in ActLoopNT-in 2.8595 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -109.78, -23.36 APE9-dihe-na -86.88, -149.11 APE8-dihe-in -108.63, 128.02 APE8-rot-in 302.45 APE67-dihe-in -58.2, -36.14 -56.96, -43.7 APE12-dist-in 11.0394 APE11-dist-in 11.2442 APE10-dist-in 5.3369 APE9-dist-in 3.7117 None None None XRAY 1.5 0.175 0.209 B 299.0 287.0 3 34 34 0 [[21, 282]] 1.0 6vrf CK1_TTBK2_HUMAN CK1 7.7e-104 352.6 1.0 262.0 262.0 162 163 164 166 168 50 64 68 138 140 139 141.0 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2
CMGC CDK11B CD11B_HUMAN 9I9IK P21127 440 740 795.0 ADP:60801 ATPlike Inactive DFGin 4.7633 14.1457 BLAminus -158.41, -152.11 58.37, 65.02 -86.96, 23.61 281.98, 74.01 -65.45, -34.44 in-in in 9.3484 Saltbr-in 3.0248 HRD-in -87.02, -49.1 60.47, 15.99 in-in-out SNCiio in-out ActLoopNT-in 2.8427 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -140.14, 178.62 APE9-dihe-na 67.65, 142.84 APE8-dihe-in -66.76, 156.24 APE8-rot-out 57.56 APE67-dihe-in -70.3, -10.82 -63.46, -38.5 APE12-dist-in 13.2936 APE11-dist-in 11.3984 APE10-dist-in 6.5133 APE9-dist-in 3.2891 None TPO595 TPO595 EM 3.5 999.0 999.0 K 442.0 268.0 35 28 22 6 [[438, 723]] 1.0 9i9i CMGC_CDK11B_HUMAN CMGC 5.1e-79 271.6 1.0 301.0 301.0 579 580 581 583 585 467 485 489 559 561 560 562.0 620 607 602 601 600 599 598 597 596 517 Cyclin-dependent kinase 11B
CMGC CDK12 CDK12_HUMAN 4NSTA Q9NYV4 716 1046 1490.0 ADP:1101 ATPlike Inactive DFGin 6.9783 15.1109 BLAminus -127.54, 179.84 60.58, 76.06 -95.3, 23.79 283.73, 86.71 -65.43, -16.77 in-in in 8.9881 Saltbr-in 3.0309 HRD-in -82.28, -56.37 71.8, 9.39 in-in-out SNCiio in-out ActLoopNT-in 2.9558 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -128.59, 153.12 APE9-dihe-na 76.09, 132.29 APE8-dihe-in -60.41, 149.83 APE8-rot-out 85.48 APE67-dihe-in -64.83, -28.79 -60.07, -39.7 APE12-dist-in 13.2466 APE11-dist-in 11.2727 APE10-dist-in 6.9953 APE9-dist-in 3.4606 None TPO893 TPO893 XRAY 2.2 0.198 0.24 A 351.0 323.0 8 29 29 0 [[727, 1020]] 1.0 4nst CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 4NSTC Q9NYV4 717 1045 1490.0 ADP:1101 ATPlike Inactive DFGin 6.9718 15.1681 BLAminus -122.49, -178.57 55.97, 75.42 -92.86, 20.68 283.24, 86.31 -56.98, -20.08 in-in in 8.8631 Saltbr-in 2.9569 HRD-in -69.12, -51.54 66.96, 15.75 in-in-out SNCiio in-out ActLoopNT-in 2.9277 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.74, 152.42 APE9-dihe-na 82.09, 126.12 APE8-dihe-in -62.22, 152.62 APE8-rot-out 78.32 APE67-dihe-in -63.16, -30.08 -57.73, -42.25 APE12-dist-in 13.2024 APE11-dist-in 11.2673 APE10-dist-in 6.9416 APE9-dist-in 3.7053 None TPO893 TPO893 XRAY 2.2 0.198 0.24 C 351.0 318.0 11 29 28 1 [[727, 1020]] 1.0 4nst CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK13 CDK13_HUMAN 5EFQA Q14004 695 1025 1512.0 ADP:1101 ATPlike Inactive DFGin 6.755 15.5888 BLAminus -141.88, 177.76 70.28, 48.66 -74.58, 17.49 278.28, 85.63 -61.09, -20.11 in-in in 8.1158 Saltbr-in 2.8139 HRD-in -86.6, -50.11 69.54, 11.28 in-in-out SNCiio in-out ActLoopNT-in 3.1368 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -127.03, -45.46 APE9-dihe-na -90.96, 147.77 APE8-dihe-in -58.82, 149.25 APE8-rot-out 183.76 APE67-dihe-in -63.13, -14.28 -57.08, -47.49 APE12-dist-in 13.2718 APE11-dist-in 11.1213 APE10-dist-in 6.9543 APE9-dist-in 3.3531 None TPO871 TPO871 XRAY 2.0 0.197 0.247 A 347.0 322.0 9 29 29 0 [[705, 998]] 1.0 5efq CMGC_CDK13_HUMAN CMGC 2.2e-85 292.5 1.0 301.0 301.0 854 855 856 858 860 734 752 756 834 836 835 837.0 896 883 878 877 876 875 874 873 872 792 Cyclin-dependent kinase 13
CMGC CDK13 CDK13_HUMAN 5EFQC Q14004 697 1031 1512.0 ADP:1101 ATPlike Inactive DFGin 6.6712 15.3958 BLAminus -141.53, 176.29 69.41, 51.5 -75.76, 17.57 280.54, 75.34 -60.62, -20.31 in-in in 8.1091 Saltbr-in 2.9445 HRD-in -87.13, -51.3 69.73, 13.1 in-in-out SNCiio in-out ActLoopNT-in 2.9383 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -124.45, -44.56 APE9-dihe-na -90.13, 148.33 APE8-dihe-in -57.19, 149.29 APE8-rot-out 181.48 APE67-dihe-in -63.2, -13.36 -56.43, -47.06 APE12-dist-in 13.4042 APE11-dist-in 11.5865 APE10-dist-in 7.0785 APE9-dist-in 3.3455 None TPO871 TPO871 XRAY 2.0 0.197 0.247 C 347.0 326.0 9 29 29 0 [[705, 998]] 1.0 5efq CMGC_CDK13_HUMAN CMGC 2.2e-85 292.5 1.0 301.0 301.0 854 855 856 858 860 734 752 756 834 836 835 837.0 896 883 878 877 876 875 874 873 872 792 Cyclin-dependent kinase 13
CMGC CDK2 CDK2_HUMAN 4I3ZA P24941 1 296 298.0 ADP:60301 ATPlike Active DFGin 6.4079 15.1483 BLAminus -137.57, -176.06 52.96, 75.44 -91.33, 19.91 280.72, 70.75 -64.88, -19.38 in-in in 8.599 Saltbr-in 2.9877 HRD-in -80.76, -55.87 72.55, 4.85 in-in-in SNCiii in-in ActLoopNT-in 2.9014 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.11, -96.25 APE9-dihe-na -51.92, 142.27 APE8-dihe-in -55.11, 135.08 APE8-rot-in 307.48 APE67-dihe-in -54.58, -26.51 -40.4, -56.95 APE12-dist-in 13.0643 APE11-dist-in 10.5846 APE10-dist-in 6.8229 APE9-dist-in 3.3051 None TPO160 TPO160 XRAY 2.05 0.199 0.228 A 296.0 296.0 0 28 28 0 [[4, 286]] 1.0 4i3z CMGC_CDK2_HUMAN CMGC 6.2e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4I3ZC P24941 1 296 298.0 ADP:60301 ATPlike Active DFGin 6.3666 15.146 BLAminus -139.14, -175.0 51.64, 79.19 -95.11, 18.85 278.6, 70.91 -64.63, -17.11 in-in in 8.6529 Saltbr-in 2.9791 HRD-in -79.85, -55.96 72.81, 4.84 in-in-in SNCiii in-in ActLoopNT-in 2.9165 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.52, -96.18 APE9-dihe-na -52.61, 142.23 APE8-dihe-in -53.61, 133.4 APE8-rot-in 308.84 APE67-dihe-in -53.33, -28.57 -37.02, -58.54 APE12-dist-in 13.0807 APE11-dist-in 10.6179 APE10-dist-in 6.8613 APE9-dist-in 3.3051 None TPO160 TPO160 XRAY 2.05 0.199 0.228 C 296.0 296.0 0 28 28 0 [[4, 286]] 1.0 4i3z CMGC_CDK2_HUMAN CMGC 6.2e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3QHRA P24941 1 296 298.0 ADP:60297 ATPlike Active DFGin 6.5567 15.1071 BLAminus -129.61, -176.27 55.27, 75.32 -97.07, 17.79 280.43, 72.68 -60.79, -23.59 in-in in 8.696 Saltbr-in 2.8804 HRD-in -78.46, -57.59 71.9, 8.99 in-in-in SNCiii in-in ActLoopNT-in 2.8774 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.99, 139.5 APE9-dihe-na 85.76, 129.74 APE8-dihe-in -56.31, 140.07 APE8-rot-in 302.24 APE67-dihe-in -65.07, -20.31 -41.24, -52.35 APE12-dist-in 12.989 APE11-dist-in 10.1708 APE10-dist-in 7.1114 APE9-dist-in 3.3412 None TPO160 TPO160 XRAY 2.17 0.18 0.21 A 298.0 296.0 0 28 28 0 [[4, 286]] 1.0 3qhr CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3QHRC P24941 1 296 298.0 ADP:60297 ATPlike Active DFGin 6.5652 15.1213 BLAminus -133.25, -174.75 53.96, 72.74 -93.36, 15.91 281.14, 71.23 -60.56, -21.49 in-in in 8.6995 Saltbr-in 2.8684 HRD-in -78.47, -57.15 72.13, 9.85 in-in-in SNCiii in-in ActLoopNT-in 2.8757 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.81, 147.52 APE9-dihe-na 81.05, 137.24 APE8-dihe-in -64.2, 137.48 APE8-rot-in 304.68 APE67-dihe-in -62.37, -22.27 -38.55, -53.11 APE12-dist-in 12.9853 APE11-dist-in 10.2322 APE10-dist-in 6.9899 APE9-dist-in 3.293 None TPO160 TPO160 XRAY 2.17 0.18 0.21 C 298.0 296.0 0 28 28 0 [[4, 286]] 1.0 3qhr CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3QHWA P24941 1 296 298.0 ADP:60297 ATPlike Active DFGin 6.4347 15.0131 BLAminus -134.08, -174.07 54.44, 75.18 -91.31, 13.19 281.29, 72.4 -60.66, -23.16 in-in in 8.6396 Saltbr-in 2.9345 HRD-in -72.46, -52.11 70.84, 4.06 in-in-in SNCiii in-in ActLoopNT-in 2.9031 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.61, -86.88 APE9-dihe-na -62.59, 147.47 APE8-dihe-in -61.56, 138.19 APE8-rot-in 297.56 APE67-dihe-in -60.69, -27.39 -44.54, -49.89 APE12-dist-in 12.9955 APE11-dist-in 10.2303 APE10-dist-in 6.7823 APE9-dist-in 3.3592 None TPO160 TPO160 XRAY 1.91 0.189 0.219 A 298.0 296.0 0 28 28 0 [[4, 286]] 1.0 3qhw CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3QHWC P24941 1 296 298.0 ADP:60297 ATPlike Active DFGin 6.4533 15.0832 BLAminus -135.33, -175.53 57.5, 71.73 -89.85, 9.67 280.79, 72.12 -55.86, -26.79 in-in in 8.6175 Saltbr-in 2.8956 HRD-in -73.76, -53.15 71.96, 3.16 in-in-in SNCiii in-in ActLoopNT-in 2.8982 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.86, -80.28 APE9-dihe-na -65.52, 146.91 APE8-dihe-in -61.19, 139.69 APE8-rot-in 298.69 APE67-dihe-in -57.2, -28.53 -47.15, -50.79 APE12-dist-in 12.997 APE11-dist-in 10.1334 APE10-dist-in 6.7222 APE9-dist-in 3.3609 None TPO160 TPO160 XRAY 1.91 0.189 0.219 C 298.0 296.0 0 28 28 0 [[4, 286]] 1.0 3qhw CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4II5A P24941 1 296 298.0 ADP:60301 ATPlike Active DFGin 6.2945 15.2747 BLAminus -136.76, -174.67 48.15, 75.69 -89.27, 15.07 281.74, 67.11 -54.49, -30.0 in-in in 8.6748 Saltbr-in 2.898 HRD-in -77.95, -58.94 72.46, 5.93 in-in-in SNCiii in-in ActLoopNT-in 2.856 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.58, 147.66 APE9-dihe-na 74.72, 130.64 APE8-dihe-in -63.5, 139.49 APE8-rot-in 303.89 APE67-dihe-in -59.35, -27.46 -47.25, -50.52 APE12-dist-in 13.1273 APE11-dist-in 10.3722 APE10-dist-in 7.0336 APE9-dist-in 3.3441 None TPO160 TPO160 XRAY 2.15 0.2 0.226 A 298.0 296.0 0 28 28 0 [[4, 286]] 1.0 4ii5 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4II5C P24941 1 296 298.0 ADP:60301 ATPlike Active DFGin 6.2891 15.2882 BLAminus -134.89, -171.63 44.93, 79.89 -96.21, 16.02 275.02, 74.95 -60.79, -24.87 in-in in 8.6656 Saltbr-in 2.9402 HRD-in -77.09, -52.7 69.17, 3.7 in-in-in SNCiii in-in ActLoopNT-in 2.8581 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.65, 138.88 APE9-dihe-na 85.57, 133.69 APE8-dihe-in -65.51, 139.86 APE8-rot-in 305.2 APE67-dihe-in -60.76, -27.54 -47.35, -49.81 APE12-dist-in 13.1414 APE11-dist-in 10.3821 APE10-dist-in 7.0612 APE9-dist-in 3.3866 None TPO160 TPO160 XRAY 2.15 0.2 0.226 C 298.0 296.0 0 28 28 0 [[4, 286]] 1.0 4ii5 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9I9JK P24941 6 284 298.0 ADP:60301 ATPlike Inactive DFGin 7.5021 16.7795 BLAminus -158.16, 171.41 58.55, 63.81 -89.46, 61.19 266.29, 72.56 161.2, 999.0 in-out in 9.1187 Saltbr-out 5.2547 HRD-in -89.48, -59.44 66.59, -3.23 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -47.83 APE8-dihe-out -98.29, 31.77 APE8-rot-out 77.96 APE67-dihe-in -64.85, -20.6 -65.62, -27.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.1296 None None None EM 3.1 999.0 999.0 K 301.0 246.0 37 28 12 16 [[4, 286]] 1.0 9i9j CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9I9KK P24941 2 292 298.0 ADP:60301 ATPlike Inactive DFGin 7.3023 15.9065 BLAminus -142.34, -176.15 60.61, 65.17 -90.86, 48.23 288.67, 80.56 -88.9, -30.85 out-out out 10.4864 Saltbr-out 5.6503 HRD-in -65.4, -52.43 72.61, -10.3 out-in-out SNCoio in-out ActLoopNT-in 2.5583 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -73.37, 146.13 APE9-dihe-na -115.04, 137.49 APE8-dihe-in -60.96, 144.59 APE8-rot-out 184.92 APE67-dihe-in -75.1, -11.28 -107.26, -12.43 APE12-dist-in 12.0105 APE11-dist-in 8.1866 APE10-dist-out 12.0491 APE9-dist-out 7.5485 None None None EM 2.4 999.0 999.0 K 301.0 276.0 15 28 28 0 [[4, 286]] 1.0 9i9k CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK7 CDK7_HUMAN 9I9IJ P50613 12 310 346.0 ADP:60401 ATPlike Inactive DFGin 6.598 15.1475 BLAminus -154.26, -174.63 55.49, 63.23 -84.52, 21.08 280.13, 83.68 -62.16, -39.37 in-out in 8.6205 Saltbr-out 4.7244 HRD-in -68.87, -48.72 60.83, 9.92 out-in-out SNCoio in-out ActLoopNT-in 2.7723 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -114.8, -59.65 APE9-dihe-na -71.54, 157.02 APE8-dihe-in -67.36, 161.57 APE8-rot-out 77.35 APE67-dihe-in -72.1, -35.43 -63.15, -31.03 APE12-dist-in 12.4211 APE11-dist-in 11.2397 APE10-dist-in 6.1345 APE9-dist-in 3.7163 None None None EM 3.5 999.0 999.0 J 391.0 294.0 5 28 28 0 [[12, 295]] 1.0 9i9i CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 9I9JJ P50613 11 310 346.0 ADP:60401 ATPlike Inactive DFGin 7.0461 15.5114 BLAminus -142.62, -171.5 55.13, 63.56 -86.1, 20.41 278.63, 86.43 -73.48, -14.71 in-in in 8.4748 Saltbr-in 3.2618 HRD-in -63.57, -47.3 66.21, -0.54 in-in-out SNCiio in-out ActLoopNT-in 2.8761 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -125.41, 160.15 APE9-dihe-na -72.91, 167.58 APE8-dihe-in -60.97, 159.12 APE8-rot-out 182.98 APE67-dihe-in -64.29, -19.96 -63.65, -26.45 APE12-dist-in 11.2078 APE11-dist-out 5.3409 APE10-dist-out 9.2018 APE9-dist-in 4.0331 None None None EM 3.1 999.0 999.0 J 391.0 290.0 10 28 23 5 [[12, 295]] 1.0 9i9j CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 9I9KJ P50613 10 310 346.0 ADP:60401 ATPlike Inactive DFGin 6.8665 15.1598 BLAminus -144.56, -175.34 58.29, 64.88 -85.43, 20.68 280.65, 74.04 -68.51, -15.78 in-in in 8.4034 Saltbr-in 3.4231 HRD-in -66.35, -48.78 67.04, 4.57 in-in-out SNCiio in-out ActLoopNT-in 2.7011 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -135.97, 162.75 APE9-dihe-na -69.89, 166.52 APE8-dihe-in -58.19, 147.77 APE8-rot-out 190.67 APE67-dihe-in -62.09, -25.1 -66.28, -24.83 APE12-dist-in 11.5433 APE11-dist-out 5.9477 APE10-dist-out 9.1593 APE9-dist-in 3.8908 None None None EM 2.4 999.0 999.0 J 391.0 301.0 0 28 28 0 [[12, 295]] 1.0 9i9k CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CSNK2A1 CSK21_HUMAN 6Z19B P68400 2 329 391.0 ADP:401 ATPlike Active DFGin 7.3985 16.1019 BLAminus -106.47, -175.56 60.6, 79.25 -100.03, 20.37 297.28, 82.12 -73.41, -21.13 in-in in 8.7167 Saltbr-in 2.7999 HRD-in -71.6, -55.48 75.88, 3.64 in-in-in SNCiii in-in ActLoopNT-in 2.9276 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.14, 153.25 APE9-dihe-na 78.4, 166.67 APE8-dihe-in -74.52, 152.52 APE8-rot-in 285.35 APE67-dihe-in -64.18, -23.8 -57.77, -45.77 APE12-dist-in 12.9676 APE11-dist-in 10.9929 APE10-dist-in 6.495 APE9-dist-in 3.5915 None None None XRAY 1.47 0.19 0.221 B 328.0 328.0 0 27 27 0 [[39, 324]] 1.0 6z19 CMGC_CSNK2A1_HUMAN CMGC 1.2e-69 240.7 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OQUB P68400 4 327 391.0 ADP:401 ATPlike Active DFGin 7.3237 16.3919 BLAminus -107.74, -171.87 52.49, 78.62 -101.36, 19.11 291.9, 83.91 -71.23, -12.83 in-in in 9.4959 Saltbr-in 2.9014 HRD-in -65.86, -46.78 65.2, 13.55 in-in-in SNCiii in-in ActLoopNT-in 2.8952 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.87, 169.85 APE9-dihe-na 66.11, 165.52 APE8-dihe-in -87.57, 142.09 APE8-rot-in 294.71 APE67-dihe-in -65.28, -26.45 -36.1, -50.26 APE12-dist-in 12.5919 APE11-dist-in 10.4195 APE10-dist-in 6.0893 APE9-dist-in 3.1538 R21S None None XRAY 2.324 0.221 0.244 B 352.0 324.0 0 27 27 0 [[39, 324]] 1.0 5oqu CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5ORKB P68400 4 326 391.0 ADP:401 ATPlike Active DFGin 7.365 16.4878 BLAminus -111.04, -174.54 54.53, 77.94 -96.47, 19.83 296.01, 82.36 -66.2, -23.13 in-in in 9.5516 Saltbr-in 3.0409 HRD-in -70.69, -49.04 67.52, 16.07 in-in-in SNCiii in-in ActLoopNT-in 2.8623 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.56, 172.18 APE9-dihe-na 65.73, 167.16 APE8-dihe-in -89.89, 143.95 APE8-rot-in 298.57 APE67-dihe-in -64.35, -23.63 -31.56, -56.57 APE12-dist-in 12.6145 APE11-dist-in 10.418 APE10-dist-in 6.0623 APE9-dist-in 3.1494 R21S None None XRAY 2.143 0.217 0.243 B 352.0 323.0 0 27 27 0 [[39, 324]] 1.0 5ork CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7QUXA P68400 2 329 391.0 ADP:60401 ATPlike Active DFGin 7.5848 16.1937 BLAminus -111.52, -172.63 60.82, 80.19 -104.84, 23.49 298.85, 85.23 -72.93, -20.15 in-in in 8.9584 Saltbr-in 2.8383 HRD-in -72.19, -52.24 72.27, 9.35 in-in-in SNCiii in-in ActLoopNT-in 2.8457 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.66, 178.74 APE9-dihe-na 61.29, -172.26 APE8-dihe-in -113.53, 144.19 APE8-rot-in 304.18 APE67-dihe-in -65.08, -18.11 -36.49, -57.4 APE12-dist-in 12.7233 APE11-dist-in 10.5788 APE10-dist-in 6.2143 APE9-dist-in 2.896 None SEP2 SEP2 XRAY 1.48 0.181 0.204 A 352.0 328.0 0 27 27 0 [[39, 324]] 1.0 7qux CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6YZHA P68400 3 329 391.0 ADP:60403 ATPlike Active DFGin 7.3857 16.3097 BLAminus -108.01, -176.38 61.1, 79.34 -99.78, 17.26 297.37, 82.49 -78.41, -8.16 in-in in 9.1307 Saltbr-in 2.8294 HRD-in -74.51, -47.7 69.86, 14.14 in-in-in SNCiii in-in ActLoopNT-in 2.8828 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.83, 175.48 APE9-dihe-na 62.95, -168.81 APE8-dihe-in -126.52, 135.38 APE8-rot-in 299.93 APE67-dihe-in -66.68, -18.66 -34.87, -54.46 APE12-dist-in 12.682 APE11-dist-in 10.343 APE10-dist-in 6.2268 APE9-dist-in 3.0838 None None None XRAY 1.19 0.173 0.19 A 398.0 327.0 0 27 27 0 [[39, 324]] 1.0 6yzh CMGC_CSNK2A1_HUMAN CMGC 2.4e-69 239.8 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6YPNB P68400 2 327 391.0 ADP:401,ADP:403 ATPlike,Allosteric Active DFGin 7.4975 16.1393 BLAminus -109.68, -177.56 60.98, 76.07 -97.07, 19.64 297.88, 85.05 -61.67, -35.53 in-in in 8.8083 Saltbr-in 3.0148 HRD-in -64.91, -46.49 66.87, 14.57 in-in-in SNCiii in-in ActLoopNT-in 2.8651 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.57, 178.38 APE9-dihe-na 58.61, -169.26 APE8-dihe-in -123.99, 137.29 APE8-rot-in 306.99 APE67-dihe-in -67.45, -16.12 -20.54, -62.85 APE12-dist-in 12.7883 APE11-dist-in 10.4586 APE10-dist-in 6.2695 APE9-dist-in 3.1801 None None None XRAY 1.58 0.207 0.247 B 329.0 326.0 0 27 27 0 [[39, 324]] 1.0 6ypn CMGC_CSNK2A1_HUMAN CMGC 1.2e-69 240.7 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5CVHA P68400 2 328 391.0 ADP:401,IHP:402 ATPlike,Allosteric Active DFGin 7.3513 16.2646 BLAminus -108.96, -174.88 56.89, 75.34 -94.42, 15.0 293.73, 80.57 -64.71, -19.68 in-in in 9.4185 Saltbr-in 2.8687 HRD-in -72.87, -47.99 69.09, 10.68 in-in-in SNCiii in-in ActLoopNT-in 2.9006 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.61, 174.2 APE9-dihe-na 62.86, 175.04 APE8-dihe-in -103.43, 141.93 APE8-rot-in 298.78 APE67-dihe-in -64.49, -19.58 -33.62, -57.11 APE12-dist-in 12.7395 APE11-dist-in 10.5441 APE10-dist-in 6.0999 APE9-dist-in 3.1153 R21S None None XRAY 1.848 0.204 0.22 A 352.0 327.0 0 27 27 0 [[39, 324]] 1.0 5cvh CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5CVHB P68400 4 327 391.0 ADP:401,IHP:402 ATPlike,Allosteric Active DFGin 7.3336 16.5055 BLAminus -108.95, -175.21 55.5, 76.34 -94.47, 15.14 293.04, 80.42 -64.89, -20.52 in-in in 9.6517 Saltbr-in 2.9197 HRD-in -71.77, -46.42 66.39, 11.3 in-in-in SNCiii in-in ActLoopNT-in 2.8914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.23, 173.23 APE9-dihe-na 63.78, 174.17 APE8-dihe-in -100.91, 142.72 APE8-rot-in 301.86 APE67-dihe-in -62.55, -20.09 -31.2, -58.6 APE12-dist-in 12.6313 APE11-dist-in 10.4259 APE10-dist-in 6.0374 APE9-dist-in 3.1186 R21S None None XRAY 1.848 0.204 0.22 B 352.0 324.0 0 27 27 0 [[39, 324]] 1.0 5cvh CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5MP8A P68400 3 327 391.0 ADP:404,RKN:406 ATPlike,Allosteric Active DFGin 7.3305 16.1632 BLAminus -110.84, -174.11 53.51, 76.37 -93.65, 17.26 296.86, 81.68 -66.57, -22.0 in-in in 9.3173 Saltbr-in 2.8626 HRD-in -67.91, -49.16 67.59, 13.12 in-in-in SNCiii in-in ActLoopNT-in 2.9047 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.47, 167.73 APE9-dihe-na 65.86, 165.2 APE8-dihe-in -87.13, 142.99 APE8-rot-in 303.44 APE67-dihe-in -64.04, -21.15 -31.41, -58.51 APE12-dist-in 12.6867 APE11-dist-in 10.4641 APE10-dist-in 6.121 APE9-dist-in 3.1624 R21S None None XRAY 1.92 0.213 0.224 A 352.0 325.0 0 27 27 0 [[39, 324]] 1.0 5mp8 CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5MP8B P68400 3 325 391.0 ADP:402,RKN:405 ATPlike,Allosteric Active DFGin 7.3235 16.3489 BLAminus -110.28, -174.91 53.58, 76.31 -93.48, 18.26 296.68, 81.06 -66.02, -21.8 in-in in 9.4483 Saltbr-in 2.9073 HRD-in -64.03, -48.98 66.77, 13.43 in-in-in SNCiii in-in ActLoopNT-in 2.9117 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.49, 167.73 APE9-dihe-na 66.13, 163.08 APE8-dihe-in -85.62, 144.24 APE8-rot-in 302.43 APE67-dihe-in -63.28, -21.33 -32.96, -58.46 APE12-dist-in 12.6455 APE11-dist-in 10.3733 APE10-dist-in 6.1129 APE9-dist-in 3.1511 R21S None None XRAY 1.92 0.213 0.224 B 352.0 323.0 0 27 27 0 [[39, 324]] 1.0 5mp8 CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5ORJB P68400 4 327 391.0 ADP:403,A4Q:404 ATPlike,Allosteric Active DFGin 7.2646 16.3413 BLAminus -111.15, -176.6 55.76, 79.82 -97.57, 16.74 293.2, 81.02 -66.75, -20.87 in-in in 9.4788 Saltbr-in 3.0155 HRD-in -67.24, -46.68 66.46, 8.84 in-in-in SNCiii in-in ActLoopNT-in 2.9685 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.61, 174.53 APE9-dihe-na 65.24, 168.77 APE8-dihe-in -97.72, 138.95 APE8-rot-in 305.57 APE67-dihe-in -64.92, -22.35 -27.33, -57.79 APE12-dist-in 12.6095 APE11-dist-in 10.4061 APE10-dist-in 6.0013 APE9-dist-in 3.1263 R21S None None XRAY 1.99 0.201 0.221 B 352.0 324.0 0 27 27 0 [[39, 324]] 1.0 5orj CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5ORKA P68400 4 327 391.0 ADP:401,A4T:404 ATPlike,Allosteric Active DFGin 7.3925 16.3137 BLAminus -113.19, -173.71 54.76, 77.71 -95.81, 17.23 296.74, 84.21 -67.53, -20.95 in-in in 9.3575 Saltbr-in 3.0228 HRD-in -73.92, -50.16 69.3, 15.04 in-in-in SNCiii in-in ActLoopNT-in 2.8727 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.23, 173.79 APE9-dihe-na 63.16, 167.87 APE8-dihe-in -90.44, 143.76 APE8-rot-in 298.85 APE67-dihe-in -64.65, -24.13 -31.17, -56.13 APE12-dist-in 12.6312 APE11-dist-in 10.4313 APE10-dist-in 6.0622 APE9-dist-in 3.1643 R21S None None XRAY 2.143 0.217 0.243 A 352.0 324.0 0 27 27 0 [[39, 324]] 1.0 5ork CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZYKA P68400 3 329 391.0 ADP:401,KEC:402 ATPlike,Allosteric Active DFGin 7.269 16.0622 BLAminus -118.69, -179.59 61.79, 73.49 -91.41, 13.81 296.07, 81.24 -64.93, -20.57 in-in in 9.1757 Saltbr-in 3.0874 HRD-in -73.86, -46.68 67.1, 11.06 in-in-in SNCiii in-in ActLoopNT-in 2.8397 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.3, 165.81 APE9-dihe-na 64.18, 165.94 APE8-dihe-in -85.42, 147.47 APE8-rot-in 296.52 APE67-dihe-in -73.89, -14.69 -37.67, -50.01 APE12-dist-in 12.7414 APE11-dist-in 10.3817 APE10-dist-in 6.2844 APE9-dist-in 3.2575 R21S,K74A,K75A,K76A None None XRAY 1.31 0.191 0.206 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 7zyk CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5MPJA P68400 3 328 391.0 ADP:401,IHP:402,J2P:403 ATPlike,Allosteric,Allosteric Active DFGin 7.3468 16.241 BLAminus -108.98, -172.35 51.93, 78.25 -97.48, 15.87 295.39, 81.91 -64.67, -20.13 in-in in 9.407 Saltbr-in 3.123 HRD-in -65.25, -50.84 66.66, 13.27 in-in-in SNCiii in-in ActLoopNT-in 2.9405 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.52, 170.99 APE9-dihe-na 63.12, 171.83 APE8-dihe-in -95.06, 139.24 APE8-rot-in 294.97 APE67-dihe-in -59.9, -28.22 -27.45, -59.89 APE12-dist-in 12.7865 APE11-dist-in 10.5397 APE10-dist-in 6.1033 APE9-dist-in 3.1634 R21S None None XRAY 2.14 0.214 0.241 A 352.0 326.0 0 27 27 0 [[39, 324]] 1.0 5mpj CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OQUA P68400 4 327 391.0 ADP:401,A4B:402,IHP:408 ATPlike,Allosteric,Allosteric Active DFGin 7.4477 16.2501 BLAminus -109.0, -171.89 53.56, 75.1 -98.21, 18.1 294.2, 83.27 -72.09, -15.18 in-in in 9.3691 Saltbr-in 2.8268 HRD-in -72.33, -46.9 69.21, 10.87 in-in-in SNCiii in-in ActLoopNT-in 2.9655 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.38, 169.57 APE9-dihe-na 63.73, 165.9 APE8-dihe-in -87.91, 142.9 APE8-rot-in 295.65 APE67-dihe-in -63.9, -27.03 -35.31, -52.27 APE12-dist-in 12.6696 APE11-dist-in 10.4664 APE10-dist-in 6.1543 APE9-dist-in 3.1404 R21S None None XRAY 2.324 0.221 0.244 A 352.0 324.0 0 27 27 0 [[39, 324]] 1.0 5oqu CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OSLA P68400 2 329 391.0 ADP:403,A9K:406,A9K:407 ATPlike,Allosteric,Allosteric Active DFGin 7.4581 16.1961 BLAminus -110.64, -174.68 55.81, 76.64 -96.18, 20.64 295.73, 82.92 -66.89, -23.66 in-in in 9.1209 Saltbr-in 2.8789 HRD-in -70.65, -51.51 73.54, 4.25 in-in-in SNCiii in-in ActLoopNT-in 2.987 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.81, 161.35 APE9-dihe-na 64.27, 160.37 APE8-dihe-in -77.24, 145.71 APE8-rot-in 308.44 APE67-dihe-in -67.76, -20.24 -38.72, -52.2 APE12-dist-in 12.8335 APE11-dist-in 10.614 APE10-dist-in 6.3337 APE9-dist-in 3.627 R21S,K74A,K75A,K76A None None XRAY 1.95 0.165 0.211 A 342.0 328.0 0 27 27 0 [[39, 324]] 1.0 5osl CMGC_CSNK2A1_HUMAN CMGC 9.4e-69 237.9 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5MOEB P68400 4 326 391.0 ADP:401,IHP:404,OQC:408,OQC:409 ATPlike,Allosteric,Allosteric,Allosteric Active DFGin 7.3649 16.3363 BLAminus -112.77, -173.88 54.48, 74.44 -91.99, 16.05 295.46, 80.22 -64.57, -20.81 in-in in 9.4786 Saltbr-in 2.889 HRD-in -71.14, -46.59 66.38, 12.51 in-in-in SNCiii in-in ActLoopNT-in 2.8725 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.91, 173.34 APE9-dihe-na 63.06, 172.04 APE8-dihe-in -102.52, 138.64 APE8-rot-in 304.11 APE67-dihe-in -65.23, -21.43 -26.29, -58.65 APE12-dist-in 12.6043 APE11-dist-in 10.4054 APE10-dist-in 6.0634 APE9-dist-in 3.1151 R21S None None XRAY 1.89 0.197 0.208 B 352.0 323.0 0 27 27 0 [[39, 324]] 1.0 5moe CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5ORJA P68400 3 327 391.0 ADP:404,A4Q:405,A4Q:406,IHP:407 ATPlike,Allosteric,Allosteric,Allosteric Active DFGin 7.3152 16.1818 BLAminus -113.3, -173.8 55.0, 78.92 -98.71, 18.23 293.93, 79.8 -66.17, -22.25 in-in in 9.3296 Saltbr-in 3.0231 HRD-in -76.84, -43.62 65.1, 10.62 in-in-in SNCiii in-in ActLoopNT-in 2.9091 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.05, 173.87 APE9-dihe-na 60.43, 175.34 APE8-dihe-in -100.91, 141.29 APE8-rot-in 294.98 APE67-dihe-in -64.65, -20.18 -32.63, -57.01 APE12-dist-in 12.6896 APE11-dist-in 10.5231 APE10-dist-in 6.1349 APE9-dist-in 3.1729 R21S None None XRAY 1.99 0.201 0.221 A 352.0 325.0 0 27 27 0 [[39, 324]] 1.0 5orj CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5MOEA P68400 3 327 391.0 ADP:401,IHP:404,OQC:409,OQC:410,OQC:411 ATPlike,Allosteric,Allosteric,Allosteric,Allosteric Active DFGin 7.3743 16.1839 BLAminus -113.03, -172.32 55.01, 74.02 -92.87, 17.49 295.96, 80.42 -65.27, -21.9 in-in in 9.335 Saltbr-in 2.8232 HRD-in -73.11, -47.25 66.93, 11.97 in-in-in SNCiii in-in ActLoopNT-in 2.8891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.86, 173.34 APE9-dihe-na 63.53, 173.35 APE8-dihe-in -101.83, 138.62 APE8-rot-in 302.36 APE67-dihe-in -64.87, -18.25 -29.63, -58.0 APE12-dist-in 12.6777 APE11-dist-in 10.5011 APE10-dist-in 6.1038 APE9-dist-in 3.1115 R21S None None XRAY 1.89 0.197 0.208 A 352.0 325.0 0 27 27 0 [[39, 324]] 1.0 5moe CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZY0A P68400 3 329 391.0 KC0:401,ADP:402 Allosteric,ATPlike Active DFGin 7.4453 16.2362 BLAminus -121.24, -177.58 61.58, 73.29 -95.57, 19.56 295.71, 82.78 -68.2, -19.93 in-in in 9.1425 Saltbr-in 2.8354 HRD-in -73.32, -51.17 71.86, 9.65 in-in-in SNCiii in-in ActLoopNT-in 2.8954 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.67, 170.29 APE9-dihe-na 67.14, 162.49 APE8-dihe-in -85.98, 150.23 APE8-rot-in 297.56 APE67-dihe-in -70.24, -15.73 -44.75, -49.95 APE12-dist-in 12.6182 APE11-dist-in 10.2666 APE10-dist-in 6.1422 APE9-dist-in 3.1596 R21S,K74A,K75A,K76A None None XRAY 1.44 0.2 0.214 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 7zy0 CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 8AE7A P68400 3 329 391.0 LVU:403,ADP:404 Allosteric,ATPlike Active DFGin 7.2701 16.1202 BLAminus -116.86, -174.55 56.89, 71.78 -90.66, 15.89 296.23, 82.47 -66.69, -21.09 in-in in 9.1657 Saltbr-in 2.9021 HRD-in -74.15, -48.16 69.73, 11.22 in-in-in SNCiii in-in ActLoopNT-in 2.8441 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.63, 168.68 APE9-dihe-na 61.6, 159.52 APE8-dihe-in -83.61, 146.39 APE8-rot-in 290.46 APE67-dihe-in -69.61, -14.41 -36.06, -54.13 APE12-dist-in 12.6687 APE11-dist-in 10.213 APE10-dist-in 6.181 APE9-dist-in 3.2278 R21S,K74A,K75A,K76A None None XRAY 1.28 0.205 0.232 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 8ae7 CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7I8IA P68400 3 329 391.0 A1BZ5:402,ADP:403 Type1,Allosteric Active DFGin 7.509 16.1976 BLAminus -114.79, -179.23 51.74, 77.25 -89.04, 19.22 296.06, 83.25 -67.78, -21.4 in-in in 9.214 Saltbr-in 2.7466 HRD-in -73.97, -49.71 72.98, 8.01 in-in-in SNCiii in-in ActLoopNT-in 2.871 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.34, 166.93 APE9-dihe-na 64.1, 155.12 APE8-dihe-in -82.08, 146.04 APE8-rot-in 277.65 APE67-dihe-in -69.99, -12.65 -33.63, -55.35 APE12-dist-in 12.8488 APE11-dist-in 10.5019 APE10-dist-in 6.3456 APE9-dist-in 3.2901 R21S,K74A,K75A,K76A None None XRAY 1.47 0.182 0.208 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 7i8i CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7I8LA P68400 3 329 391.0 A1B0I:401,ADP:402 Type1,Allosteric Active DFGin 7.4692 16.1742 BLAminus -114.83, -178.51 53.33, 76.08 -89.6, 18.77 294.58, 80.79 -67.15, -22.69 in-in in 9.2225 Saltbr-in 2.7653 HRD-in -77.98, -46.47 70.26, 9.7 in-in-in SNCiii in-in ActLoopNT-in 2.8844 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.24, 169.88 APE9-dihe-na 62.42, 155.06 APE8-dihe-in -81.97, 147.51 APE8-rot-in 279.2 APE67-dihe-in -72.11, -11.91 -35.53, -53.62 APE12-dist-in 12.8613 APE11-dist-in 10.5177 APE10-dist-in 6.3932 APE9-dist-in 3.2941 R21S,K74A,K75A,K76A None None XRAY 1.48 0.184 0.203 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 7i8l CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7I8QA P68400 3 329 391.0 A1BZU:402,ADP:403 Type1,Allosteric Active DFGin 7.4792 16.1471 BLAminus -114.23, -175.31 54.63, 75.78 -91.18, 24.13 295.07, 81.04 -69.52, -25.94 in-in in 8.9728 Saltbr-in 2.7604 HRD-in -73.41, -51.65 72.74, 4.84 in-in-in SNCiii in-in ActLoopNT-in 2.8878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.8, 171.34 APE9-dihe-na 61.22, 163.5 APE8-dihe-in -95.71, 145.02 APE8-rot-in 296.25 APE67-dihe-in -71.38, -16.61 -34.03, -51.24 APE12-dist-in 12.8091 APE11-dist-in 10.4409 APE10-dist-in 6.2561 APE9-dist-in 3.114 R21S,K74A,K75A,K76A None None XRAY 1.66 0.191 0.22 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 7i8q CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC GSK3B GSK3B_HUMAN 4NM5A P49841 24 383 420.0 ADP:60401 ATPlike Active DFGin 6.5502 14.0064 BLAminus -136.16, -177.73 61.88, 88.47 -108.64, 28.76 287.87, 80.78 -73.66, -15.44 in-in in 8.6187 Saltbr-in 2.6732 HRD-in -65.83, -43.73 64.82, 15.23 in-in-in SNCiii in-in ActLoopNT-in 2.8386 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.92, 173.97 APE9-dihe-na 66.26, 147.02 APE8-dihe-in -77.1, 152.8 APE8-rot-in 293.28 APE67-dihe-inflip 82.03, -25.76 -52.23, 150.7 APE12-dist-in 13.2793 APE11-dist-in 11.5989 APE10-dist-in 6.9485 APE9-dist-in 3.2377 None None None XRAY 2.3 0.185 0.232 A 377.0 360.0 0 27 27 0 [[56, 340]] 1.0 4nm5 CMGC_GSK3B_HUMAN CMGC 2.3e-70 243.3 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 4NM7A P49841 25 383 420.0 ADP:60401 ATPlike Active DFGin 6.5153 13.993 BLAminus -137.35, -178.06 62.82, 88.6 -107.3, 24.56 288.41, 80.2 -69.84, -12.63 in-in in 8.8181 Saltbr-in 2.743 HRD-in -66.5, -46.64 67.84, 11.79 in-in-in SNCiii in-in ActLoopNT-in 2.8287 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.92, 172.54 APE9-dihe-na 68.99, 153.43 APE8-dihe-in -86.9, 151.79 APE8-rot-in 300.04 APE67-dihe-inflip 84.67, -25.93 -50.38, 146.2 APE12-dist-in 13.3553 APE11-dist-in 11.6779 APE10-dist-in 6.9055 APE9-dist-in 3.2102 None None None XRAY 2.3 0.185 0.234 A 377.0 354.0 2 27 27 0 [[56, 340]] 1.0 4nm7 CMGC_GSK3B_HUMAN CMGC 2.3e-70 243.3 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 4NM0A P49841 26 383 420.0 ADP:60408 ATPlike Inactive DFGin 6.641 14.2129 BLAminus -133.4, -174.33 56.9, 85.51 -105.72, 27.83 287.31, 80.39 -76.48, -2.57 in-in in 8.774 Saltbr-in 3.0941 HRD-in -69.87, -45.12 67.03, 14.87 in-in-out SNCiio in-out ActLoopNT-in 2.9268 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -71.29, 168.54 APE9-dihe-na 70.19, 144.11 APE8-dihe-in -96.47, 160.21 APE8-rot-out 64.82 APE67-dihe-inflip 78.46, -27.02 -43.67, 149.07 APE12-dist-in 13.0905 APE11-dist-in 10.885 APE10-dist-in 6.5705 APE9-dist-in 3.1347 None None None XRAY 2.5 0.193 0.239 A 389.0 355.0 0 27 27 0 [[56, 340]] 1.0 4nm0 CMGC_GSK3B_HUMAN CMGC 2.5e-70 243.2 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 4NM3A P49841 6 383 420.0 ADP:60409 ATPlike Active DFGin 6.4747 13.947 BLAminus -129.98, -178.05 63.17, 87.87 -103.96, 21.26 289.38, 80.04 -65.46, -16.35 in-in in 8.8058 Saltbr-in 2.7256 HRD-in -69.81, -46.77 71.59, 6.75 in-in-in SNCiii in-in ActLoopNT-in 2.7503 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.34, 169.99 APE9-dihe-na 69.15, 146.37 APE8-dihe-in -83.47, 151.55 APE8-rot-in 296.54 APE67-dihe-inflip 86.0, -31.11 -49.79, 146.79 APE12-dist-in 13.2688 APE11-dist-in 11.4837 APE10-dist-in 6.9065 APE9-dist-in 3.1117 None SEP9 SEP9 XRAY 2.1 0.197 0.242 A 389.0 357.0 2 27 27 0 [[56, 340]] 1.0 4nm3 CMGC_GSK3B_HUMAN CMGC 2.5e-70 243.2 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 1J1CA P49841 35 388 420.0 ADP:60430 ATPlike Active DFGin 6.8122 13.9298 BLAminus -139.24, -179.75 62.79, 82.17 -97.34, 25.19 286.68, 82.3 -65.83, -19.9 in-in in 8.6015 Saltbr-in 2.6465 HRD-in -68.65, -43.85 68.34, 7.36 in-in-in SNCiii in-in ActLoopNT-in 2.9774 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -90.05, 172.96 APE9-dihe-na 78.17, 130.85 APE8-dihe-in -73.54, 145.97 APE8-rot-in 310.16 APE67-dihe-inflip 99.09, -35.01 -54.43, 141.28 APE12-dist-in 13.0771 APE11-dist-in 11.0674 APE10-dist-in 5.9263 APE9-dist-in 3.1997 None None None XRAY 2.1 0.218 0.242 A 420.0 354.0 0 27 27 0 [[56, 340]] 1.0 1j1c CMGC_GSK3B_HUMAN CMGC 3.2e-70 242.8 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 1J1CB P49841 23 386 420.0 ADP:60930 ATPlike Active DFGin 6.6935 13.7094 BLAminus -138.27, -179.99 63.33, 82.68 -100.46, 28.2 289.88, 80.26 -70.45, -13.94 in-in in 8.52 Saltbr-in 2.738 HRD-in -67.92, -43.36 67.59, 5.86 in-in-in SNCiii in-in ActLoopNT-in 2.9803 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -91.71, 170.27 APE9-dihe-na 78.71, 139.86 APE8-dihe-in -81.56, 140.05 APE8-rot-in 302.5 APE67-dihe-inflip 101.62, -36.53 -50.52, 137.44 APE12-dist-in 12.8683 APE11-dist-in 11.1277 APE10-dist-in 6.0252 APE9-dist-in 3.2076 None None None XRAY 2.1 0.218 0.242 B 420.0 364.0 0 27 27 0 [[56, 340]] 1.0 1j1c CMGC_GSK3B_HUMAN CMGC 3.2e-70 242.8 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC MAPK1 MK01_HUMAN 4IZ5A P28482 11 357 360.0 ADP:900 ATPlike Inactive DFGin 6.5744 16.2257 BLAminus -133.03, 170.47 61.68, 96.87 -113.24, 29.97 280.98, 72.88 -75.05, -15.97 in-out in 8.9431 Saltbr-out 6.3365 HRD-in -70.37, -54.19 76.22, -6.05 out-in-out SNCoio in-out ActLoopNT-in 2.8045 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -135.59, 107.64 APE9-dihe-na -86.59, -36.52 APE8-dihe-in -63.86, 130.93 APE8-rot-in 305.07 APE67-dihe-in -64.33, -26.99 -124.19, 30.24 APE12-dist-in 10.0117 APE11-dist-out 7.082 APE10-dist-out 8.2491 APE9-dist-out 10.5104 T185E None None XRAY 3.19 0.245 0.292 A 356.0 347.0 0 31 31 0 [[25, 313]] 1.0 4iz5 CMGC_MAPK1_HUMAN CMGC 2.5e-85 292.3 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4IZ5B P28482 11 357 360.0 ADP:900 ATPlike Inactive DFGin 6.6142 16.236 BLAminus -130.77, 169.05 63.18, 96.88 -112.33, 27.86 280.9, 72.0 -73.48, -17.21 in-out in 8.9516 Saltbr-out 6.2842 HRD-in -71.55, -52.24 74.21, -4.59 out-in-out SNCoio in-out ActLoopNT-in 2.846 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -135.05, 108.67 APE9-dihe-na -88.18, -35.19 APE8-dihe-in -65.83, 129.75 APE8-rot-in 303.93 APE67-dihe-in -64.9, -24.28 -122.7, 29.42 APE12-dist-in 10.0315 APE11-dist-out 7.0852 APE10-dist-out 8.2498 APE9-dist-out 10.5027 T185E None None XRAY 3.19 0.245 0.292 B 356.0 347.0 0 31 31 0 [[25, 313]] 1.0 4iz5 CMGC_MAPK1_HUMAN CMGC 2.5e-85 292.3 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4IZ5C P28482 11 357 360.0 ADP:900 ATPlike Inactive DFGin 6.6044 16.2316 BLAminus -131.01, 170.44 62.04, 96.83 -112.78, 28.94 280.74, 73.4 -74.17, -17.63 in-out in 8.9448 Saltbr-out 6.3598 HRD-in -72.88, -51.67 75.48, -6.0 out-in-out SNCoio in-out ActLoopNT-in 2.8678 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -133.99, 108.02 APE9-dihe-na -87.46, -36.5 APE8-dihe-in -65.77, 130.32 APE8-rot-in 303.26 APE67-dihe-in -66.37, -24.82 -122.99, 29.53 APE12-dist-in 10.0145 APE11-dist-out 7.0682 APE10-dist-out 8.2202 APE9-dist-out 10.4967 T185E None None XRAY 3.19 0.245 0.292 C 356.0 347.0 0 31 31 0 [[25, 313]] 1.0 4iz5 CMGC_MAPK1_HUMAN CMGC 2.5e-85 292.3 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4IZ5D P28482 11 357 360.0 ADP:900 ATPlike Inactive DFGin 6.6009 16.2317 BLAminus -131.94, 170.02 62.64, 97.08 -112.75, 27.73 280.79, 72.08 -72.23, -17.73 in-out in 8.9604 Saltbr-out 6.3214 HRD-in -71.89, -53.7 75.24, -4.58 out-in-out SNCoio in-out ActLoopNT-in 2.8465 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -135.09, 108.16 APE9-dihe-na -88.37, -35.4 APE8-dihe-in -66.59, 130.93 APE8-rot-in 303.88 APE67-dihe-in -65.41, -25.44 -123.75, 30.53 APE12-dist-in 10.0122 APE11-dist-out 7.0881 APE10-dist-out 8.224 APE9-dist-out 10.4605 T185E None None XRAY 3.19 0.245 0.292 D 356.0 347.0 0 31 31 0 [[25, 313]] 1.0 4iz5 CMGC_MAPK1_HUMAN CMGC 2.5e-85 292.3 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC PRP4K PRP4K_HUMAN 4IFCA Q13523 668 1005 1007.0 ADP:1101 ATPlike Inactive DFGin 6.3208 14.3632 BLAminus -121.88, -179.85 58.81, 82.85 -100.37, 25.78 288.2, 87.48 -70.57, -26.82 in-in in 8.2572 Saltbr-in 2.8437 HRD-in -62.43, -44.6 59.26, 25.1 in-in-out SNCiio in-out ActLoopNT-in 2.8159 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -73.15, 134.81 APE9-dihe-na 75.99, 141.41 APE8-dihe-in -55.8, 125.16 APE8-rot-in 286.42 APE67-dihe-in -66.36, -24.99 -29.31, -53.31 APE12-dist-out 15.5377 APE11-dist-in 11.8311 APE10-dist-out 8.8713 APE9-dist-in 3.2866 None PTR849 PTR849 XRAY 2.13 0.243 0.256 A 358.0 328.0 10 26 26 0 [[687, 1003]] 1.0 4ifc CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1.0 301.0 301.0 833 834 835 837 839 717 732 736 812 814 813 815.0 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
CMGC PRP4K PRP4K_HUMAN 4IFCB Q13523 670 1005 1007.0 ADP:1101 ATPlike Inactive DFGin 6.419 14.3427 BLAminus -121.41, 176.18 59.35, 85.75 -102.3, 24.13 289.47, 86.91 -69.6, -26.74 in-in in 8.3192 Saltbr-in 2.7793 HRD-in -64.36, -42.37 58.06, 25.43 in-in-out SNCiio in-out ActLoopNT-in 2.9005 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -73.87, 139.78 APE9-dihe-na 75.02, 140.04 APE8-dihe-in -56.36, 124.13 APE8-rot-in 293.29 APE67-dihe-in -65.74, -25.94 -27.6, -52.65 APE12-dist-out 15.5374 APE11-dist-in 11.8086 APE10-dist-out 8.5765 APE9-dist-in 3.2507 None PTR849 PTR849 XRAY 2.13 0.243 0.256 B 358.0 330.0 6 26 26 0 [[687, 1003]] 1.0 4ifc CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1.0 301.0 301.0 833 834 835 837 839 717 732 736 812 814 813 815.0 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
CMGC SRPK1 SRPK1_HUMAN 1WBPA Q96SB4 67 655 655.0 ADP:60950 ATPlike Active DFGin 6.0934 14.4839 BLAminus -120.66, 177.09 55.57, 73.12 -93.78, 28.92 297.48, 63.42 -60.8, -41.52 in-in in 9.6161 Saltbr-in 3.5335 HRD-in -64.25, -33.37 61.64, -4.85 in-in-in SNCiii in-in ActLoopNT-in 2.8547 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.23, 175.25 APE9-dihe-na 64.87, 133.49 APE8-dihe-in -68.33, 140.58 APE8-rot-in 294.72 APE67-dihe-in -48.4, -19.96 -25.96, -79.02 APE12-dist-in 12.4206 APE11-dist-in 10.401 APE10-dist-in 7.4554 APE9-dist-in 2.9725 None None None XRAY 2.4 0.228 0.247 A 397.0 350.0 22 25 25 0 [[80, 653]] 1.0 1wbp CMGC_SRPK1_HUMAN CMGC 2e-139 469.9 1.0 301.0 301.0 496 497 498 500 502 109 124 128 210 212 211 213.0 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
NEK NEK2 NEK2_HUMAN 2W5AA P51955 3 271 445.0 ADP:61280 ATPlike Inactive None 12.6449 15.9152 None -79.34, 164.62 -62.62, 148.1 -64.74, -38.56 187.15, 76.57 112.78, 109.44 out-out out 13.1339 Saltbr-out 14.4222 HRD-out -72.83, 129.73 -137.0, 151.51 out-out-out SNCooo out-out ActLoopNT-out 11.6377 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -50.6, -46.29 APE9-dihe-na -59.22, 149.78 APE8-dihe-in -97.74, 124.68 APE8-rot-in 301.95 APE67-dihe-out -55.08, -31.55 -81.03, 66.49 APE12-dist-out 14.6679 APE11-dist-out 19.1477 APE10-dist-out 20.0287 APE9-dist-out 14.9014 None None None XRAY 1.55 0.173 0.19 A 279.0 259.0 10 28 25 3 [[8, 271]] 1.0 2w5a NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1.0 256.0 256.0 158 159 160 162 164 37 55 59 138 140 139 141.0 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK NEK7 NEK7_HUMAN 9NFQC Q8TDX7 20 300 302.0 ADP:1301 ATPlike Inactive DFGin 7.3069 11.9804 None -150.16, -164.53 74.32, -54.68 63.51, 118.45 304.42, 170.07 -50.32, 115.41 out-out out 14.52 Saltbr-out 10.4482 HRD-in -75.46, -45.69 71.31, -4.13 out-out-out SNCooo out-out ActLoopNT-out 9.1773 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -73.74, 126.83 APE9-dihe-na 80.61, 29.64 APE8-dihe-in -127.17, 154.0 APE8-rot-out 66.52 APE67-dihe-out -56.05, -43.39 -68.04, 167.92 APE12-dist-out 15.571 APE11-dist-out 14.5314 APE10-dist-out 11.8253 APE9-dist-out 8.4872 None None None XRAY 3.25 0.214 0.261 C 304.0 281.0 0 28 28 0 [[34, 294]] 1.0 9nfq NEK_NEK7_HUMAN NEK 4.3e-110 373.2 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 2WQNA Q8TDX7 21 300 302.0 ADP:1301 ATPlike Inactive DFGin 7.3657 14.509 None -71.0, 173.16 -64.84, 135.91 -62.15, 999.0 305.22, 52.49 999.0, 999.0 out-out out 14.0336 Saltbr-out 12.9475 HRD-in -74.75, -50.15 86.13, -19.52 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 77.46 APE8-rot-none 999.0 APE67-dihe-out -63.25, -48.51 -54.4, 143.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.192 0.221 A 310.0 259.0 21 28 10 18 [[34, 294]] 1.0 2wqn NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
OTHER BUB1 BUB1_HUMAN 4QPMA O43683 740 1083 1085.0 ADP:61501 ATPlike Inactive DFGin 4.9806 12.0103 BLAminus -120.67, -179.49 71.42, 87.57 -106.61, 23.42 308.95, 170.82 -66.89, -34.13 in-in in 7.7961 Saltbr-in 2.9136 HRD-in -66.14, -48.04 82.18, -4.6 in-in-out SNCiio in-out ActLoopNT-in 2.7633 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -64.85, 156.56 APE9-dihe-na -64.63, -39.16 APE8-dihe-in -93.29, 139.46 APE8-rot-in 316.87 APE67-dihe-in -78.63, -37.4 -63.71, -30.48 APE12-dist-in 11.7254 APE11-dist-out 14.148 APE10-dist-out 10.6353 APE9-dist-out 10.7918 None SEP969 SEP969 XRAY 2.202 0.231 0.269 A 356.0 329.0 15 30 30 0 [[787, 1056]] 1.0 4qpm OTHER_BUB1_HUMAN BUB 3.8e-136 458.4 1.0 265.0 265.0 945 946 947 949 951 821 830 834 914 916 915 917.0 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN 4QPMB O43683 740 1081 1085.0 ADP:61501 ATPlike Inactive DFGin 5.1011 12.0458 BLAminus -119.58, -176.38 67.12, 86.64 -105.74, 27.36 310.01, 169.79 -71.02, -28.54 in-in in 7.7718 Saltbr-in 2.9014 HRD-in -61.72, -45.96 85.02, -11.94 in-in-out SNCiio in-out ActLoopNT-in 2.7443 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -63.28, 153.27 APE9-dihe-na -53.34, -51.78 APE8-dihe-in -91.15, 141.66 APE8-rot-in 311.67 APE67-dihe-in -72.26, -39.02 -59.96, -32.38 APE12-dist-in 11.6975 APE11-dist-out 14.0616 APE10-dist-out 10.1164 APE9-dist-out 11.0219 None SEP969 SEP969 XRAY 2.202 0.231 0.269 B 356.0 328.0 14 30 30 0 [[787, 1056]] 1.0 4qpm OTHER_BUB1_HUMAN BUB 3.8e-136 458.4 1.0 265.0 265.0 945 946 947 949 951 821 830 834 914 916 915 917.0 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN 4R8QA O43683 736 1083 1085.0 ADP:1501 ATPlike Inactive DFGin 5.1224 11.8292 BLAminus -125.96, -174.79 66.73, 90.85 -108.81, 15.71 306.38, 172.71 -63.09, -30.66 in-in in 7.7114 Saltbr-in 2.8745 HRD-in -64.09, -49.64 83.12, -3.69 in-in-out SNCiio in-out ActLoopNT-in 2.7626 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iooo APE10-dihe-na -164.58, 163.81 APE9-dihe-na -85.55, 176.61 APE8-dihe-out -73.85, 5.37 APE8-rot-in 315.03 APE67-dihe-out 103.71, -26.99 -140.38, 18.96 APE12-dist-in 11.7437 APE11-dist-out 16.3238 APE10-dist-out 13.2043 APE9-dist-out 6.446 None None None XRAY 2.31 0.226 0.264 A 365.0 332.0 16 30 30 0 [[787, 1056]] 1.0 4r8q OTHER_BUB1_HUMAN BUB 4.2e-136 458.3 1.0 265.0 265.0 945 946 947 949 951 821 830 834 914 916 915 917.0 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN 5DMZA O43683 735 1083 1085.0 ADP:1101 ATPlike Inactive DFGin 5.221 12.0677 BLAminus -133.45, -169.91 60.82, 85.13 -106.54, 14.57 302.2, 157.68 -62.7, -37.35 in-out in 7.7014 Saltbr-out 3.7639 HRD-in -69.13, -48.67 85.78, -11.89 out-in-out SNCoio in-out ActLoopNT-in 2.8654 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iooi APE10-dihe-na -165.83, 155.63 APE9-dihe-na -80.56, 157.26 APE8-dihe-out -52.44, -38.51 APE8-rot-in 307.01 APE67-dihe-out 105.78, 2.77 -74.96, -12.99 APE12-dist-in 11.7853 APE11-dist-out 16.0361 APE10-dist-out 12.5398 APE9-dist-in 5.9432 None SEP969 SEP969 XRAY 2.4 0.212 0.245 A 365.0 340.0 9 30 30 0 [[787, 1056]] 1.0 5dmz OTHER_BUB1_HUMAN BUB 4.2e-136 458.3 1.0 265.0 265.0 945 946 947 949 951 821 830 834 914 916 915 917.0 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN 5DMZB O43683 735 1083 1085.0 ADP:1101 ATPlike Inactive DFGin 5.2199 11.8525 BLAminus -128.64, -170.27 62.18, 89.46 -111.04, 16.28 301.8, 159.34 -67.29, -36.18 in-out in 7.5716 Saltbr-out 4.0246 HRD-in -67.97, -51.5 86.46, -15.21 out-in-out SNCoio in-out ActLoopNT-in 2.8449 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iooi APE10-dihe-na -164.62, 154.63 APE9-dihe-na -71.85, 159.91 APE8-dihe-out -55.62, -36.95 APE8-rot-in 307.18 APE67-dihe-out 117.19, -7.42 -77.21, -19.75 APE12-dist-in 11.5746 APE11-dist-out 15.552 APE10-dist-out 12.2656 APE9-dist-in 5.7424 None SEP969 SEP969 XRAY 2.4 0.212 0.245 B 365.0 340.0 9 30 30 0 [[787, 1056]] 1.0 5dmz OTHER_BUB1_HUMAN BUB 4.2e-136 458.3 1.0 265.0 265.0 945 946 947 949 951 821 830 834 914 916 915 917.0 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER CDC7 CDC7_HUMAN 4F99A O00311 41 572 574.0 ADP:601 ATPlike None DFGin 5.8696 13.865 BLAminus -125.0, 176.56 71.88, 86.33 -103.78, 20.73 291.54, 82.68 -65.96, -16.39 in-in in 8.7935 Saltbr-in 3.139 HRD-in -63.98, -49.82 74.42, -3.19 in-in-none SNCiin in-none ActLoopNT-in 2.7316 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -77.05, 117.3 APE8-rot-in 305.41 APE67-dihe-in -66.81, -0.89 -45.84, -42.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.33 0.194 0.241 A 361.0 312.0 42 188 168 20 [[58, 569]] 1.0 4f99 OTHER_CDC7_HUMAN CMGC 2e-18 137.7 1.0 161.0 295.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 4F9AA O00311 39 572 574.0 ADP:601 ATPlike None DFGin 5.7594 13.9364 BLAminus -128.61, 175.54 70.41, 87.99 -103.92, 20.97 294.06, 81.72 -65.32, -14.75 in-in in 8.7565 Saltbr-in 3.4076 HRD-in -57.32, -50.7 72.28, 5.36 in-in-none SNCiin in-none ActLoopNT-in 2.9281 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -93.93, 115.55 APE8-rot-in 301.45 APE67-dihe-in -62.39, -13.04 -45.16, -41.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.17 0.208 0.25 A 361.0 315.0 41 188 168 20 [[58, 569]] 1.0 4f9a OTHER_CDC7_HUMAN CMGC 2e-18 137.7 1.0 161.0 295.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 4F9AC O00311 37 572 574.0 ADP:601 ATPlike None DFGin 5.9131 14.2074 BLAminus -118.89, -178.58 68.69, 81.33 -98.73, 26.53 287.38, 89.39 -66.37, -28.9 in-in in 8.8461 Saltbr-in 2.6338 HRD-in -64.95, -54.17 83.11, 0.13 in-in-none SNCiin in-none ActLoopNT-in 2.6428 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -84.47, 120.44 APE8-rot-in 299.37 APE67-dihe-in -57.71, -12.62 -43.45, -49.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.17 0.208 0.25 C 361.0 317.0 41 188 168 20 [[58, 569]] 1.0 4f9a OTHER_CDC7_HUMAN CMGC 2e-18 137.7 1.0 161.0 295.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 6YA7A O00311 39 573 574.0 ADP:60604 ATPlike None DFGin 5.8885 14.044 BLAminus -126.02, 169.07 75.11, 84.03 -93.96, 22.86 290.05, 97.62 -71.31, -16.58 in-in in 8.9367 Saltbr-in 2.7749 HRD-in -69.05, -41.87 77.4, -14.54 in-in-none SNCiin in-none ActLoopNT-in 2.8118 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 153.99, -157.91 APE8-dihe-in -128.95, 137.92 APE8-rot-in 297.63 APE67-dihe-inflip 100.28, -12.86 -58.0, 134.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.7143 None None None XRAY 1.67 0.158 0.185 A 358.0 345.0 5 188 183 5 [[58, 569]] 1.0 6ya7 OTHER_CDC7_HUMAN CMGC 2e-18 137.3 1.0 161.0 296.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 375 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 6YA8A O00311 38 572 574.0 ADP:60601,BEF:60603 ATPlike,Allosteric None DFGin 6.1681 14.0868 BLAminus -118.93, 173.08 76.34, 83.66 -102.33, 21.87 291.62, 81.2 -67.07, -22.7 in-in in 8.7089 Saltbr-in 2.7382 HRD-in -65.76, -44.2 72.35, -4.4 in-in-none SNCiin in-none ActLoopNT-in 2.755 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na -83.06, -154.71 APE8-dihe-in -48.63, 132.1 APE8-rot-in 306.86 APE67-dihe-in -66.07, -7.37 -59.08, -35.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.8876 None None None XRAY 1.79 0.167 0.197 A 359.0 338.0 13 188 175 13 [[58, 569]] 1.0 6ya8 OTHER_CDC7_HUMAN CMGC 2e-18 137.3 1.0 161.0 296.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 375 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 6D3KA P19525 256 544 551.0 ADP:601 ATPlike Inactive DFGin 6.1925 14.1139 BLAminus -129.83, -165.99 54.1, 79.73 -96.08, 34.77 294.46, 85.4 -58.44, -36.42 in-in in 8.7206 Saltbr-in 3.027 HRD-in -84.66, -50.66 80.44, -19.76 in-in-out SNCiio in-out ActLoopNT-in 2.9759 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 139.0 APE8-rot-out 55.24 APE67-dihe-out -85.5, -25.12 -112.78, 51.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.212 0.266 A 323.0 258.0 31 27 17 10 [[175, 537]] 1.0 6d3k OTHER_EIF2AK2_HUMAN OTHER 3.5e-49 173.8 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 6D3KB P19525 255 541 551.0 ADP:601 ATPlike Inactive DFGin 6.3934 14.2206 BLAminus -124.42, -164.03 49.77, 78.4 -95.78, 27.52 286.59, 80.74 -46.98, -40.31 in-in in 8.5703 Saltbr-in 2.9665 HRD-in -83.22, -38.98 75.5, -28.78 in-in-out SNCiio in-out ActLoopNT-in 3.1489 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -18.31 APE8-rot-in 303.08 APE67-dihe-out -107.33, 146.38 64.92, 69.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.212 0.266 B 323.0 254.0 33 27 16 11 [[175, 537]] 1.0 6d3k OTHER_EIF2AK2_HUMAN OTHER 3.5e-49 173.8 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 6D3KC P19525 257 541 551.0 ADP:601 ATPlike Inactive DFGin 6.3125 14.4662 BLAminus -121.59, -161.34 59.64, 70.11 -92.29, 27.04 287.49, 78.94 -65.31, -34.89 in-in in 8.5127 Saltbr-in 2.6756 HRD-in -58.89, -48.8 72.65, -1.02 in-in-out SNCiio in-out ActLoopNT-in 2.8855 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 168.95 APE8-dihe-in -45.87, 135.3 APE8-rot-out 180.18 APE67-dihe-in -61.65, -21.89 -90.59, -3.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.1936 None None None XRAY 2.6 0.212 0.266 C 323.0 258.0 27 27 24 3 [[175, 537]] 1.0 6d3k OTHER_EIF2AK2_HUMAN OTHER 3.5e-49 173.8 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER ERN1 ERN1_HUMAN 4YZDA O75460 563 964 977.0 ADP:1002 ATPlike Inactive DFGin 7.1061 13.4537 BLBplus -141.52, 169.79 75.76, 4.13 -62.0, 156.83 53.76, 79.18 72.65, 35.33 out-out out 15.8851 Saltbr-out 13.4097 HRD-in -64.16, -47.27 74.91, -18.55 out-out-out SNCooo out-out ActLoopNT-out 10.5839 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -69.65, 158.55 APE9-dihe-na 98.62, 175.79 APE8-dihe-in -108.17, 135.68 APE8-rot-in 302.59 APE67-dihe-inflip 100.94, -24.59 -56.48, 129.95 APE12-dist-none 999.0 APE11-dist-in 13.4057 APE10-dist-out 8.1612 APE9-dist-in 3.4231 None None None XRAY 3.102 0.234 0.273 A 405.0 383.0 18 31 19 12 [[571, 832]] 1.0 4yzd OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZDB O75460 563 963 977.0 ADP:1002 ATPlike Inactive DFGin 7.2039 13.1793 BLBplus -141.12, 169.65 69.57, 15.58 -67.08, 155.42 48.06, 78.07 72.22, 36.23 out-out out 15.8795 Saltbr-out 13.1182 HRD-in -63.57, -45.81 74.7, -19.84 out-out-none SNCoon out-none ActLoopNT-out 10.5805 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -69.77, 158.99 APE9-dihe-na 99.89, 174.78 APE8-dihe-in -110.07, 134.42 APE8-rot-in 300.85 APE67-dihe-inflip 103.95, -24.75 -57.78, 133.16 APE12-dist-none 999.0 APE11-dist-in 12.6724 APE10-dist-in 7.5681 APE9-dist-in 3.5283 None None None XRAY 3.102 0.234 0.273 B 405.0 385.0 15 31 19 12 [[571, 832]] 1.0 4yzd OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZDC O75460 563 964 977.0 ADP:1001 ATPlike Inactive DFGin 7.2921 13.5559 BLBplus -142.06, 170.34 76.33, 5.28 -64.41, 157.35 50.79, 79.33 73.41, 36.41 out-out out 16.1942 Saltbr-out 13.2528 HRD-in -63.95, -47.78 74.02, -20.41 out-out-none SNCoon out-none ActLoopNT-out 10.5812 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -70.78, 158.57 APE9-dihe-na 97.6, 174.43 APE8-dihe-in -111.17, 134.53 APE8-rot-in 303.43 APE67-dihe-inflip 103.93, -24.42 -56.8, 132.74 APE12-dist-none 999.0 APE11-dist-in 12.4096 APE10-dist-in 7.7835 APE9-dist-in 3.412 None None None XRAY 3.102 0.234 0.273 C 405.0 379.0 21 31 19 12 [[571, 832]] 1.0 4yzd OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 3P23A O75460 563 963 977.0 ADP:1002 ATPlike Inactive DFGin 7.3396 13.7092 BLBplus -135.51, 176.11 64.76, 22.4 -82.8, 150.63 49.7, 79.84 86.4, 10.86 out-out out 16.0885 Saltbr-out 13.0695 HRD-in -67.24, -58.17 81.51, -4.45 out-out-out SNCooo out-out ActLoopNT-out 10.4016 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -84.29, 161.18 APE9-dihe-na 82.17, -162.33 APE8-dihe-in -132.44, 136.42 APE8-rot-in 302.1 APE67-dihe-inflip 108.83, 5.18 -54.01, 119.49 APE12-dist-none 999.0 APE11-dist-in 12.5576 APE10-dist-out 9.1227 APE9-dist-in 3.1961 None None None XRAY 2.7 0.238 0.294 A 432.0 386.0 15 31 19 12 [[571, 832]] 1.0 3p23 OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 3P23B O75460 564 964 977.0 ADP:1002 ATPlike Inactive DFGin 7.4832 13.6464 BLBplus -139.9, 176.5 76.83, 14.87 -83.89, 150.35 55.49, 87.42 97.57, -33.78 out-out out 15.9363 Saltbr-out 12.6575 HRD-in -62.38, -39.7 42.05, 35.85 out-out-out SNCooo out-out ActLoopNT-out 9.7011 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 143.86 APE9-dihe-na -111.46, -135.27 APE8-dihe-in -106.96, 135.19 APE8-rot-in 295.43 APE67-dihe-inflip 111.53, -14.08 -51.84, 125.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.2132 APE9-dist-in 3.4766 None None None XRAY 2.7 0.238 0.294 B 432.0 386.0 15 31 19 12 [[571, 832]] 1.0 3p23 OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 3P23C O75460 561 964 977.0 ADP:1002 ATPlike Inactive DFGin 7.5436 13.1728 BLBplus -149.53, -176.42 65.18, 18.98 -70.01, 144.07 39.63, 91.88 97.04, -114.33 out-out out 15.805 Saltbr-out 13.146 HRD-in -52.59, -55.72 76.18, 1.65 out-out-out SNCooo out-out ActLoopNT-out 11.1417 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iioi APE10-dihe-na -53.61, -99.6 APE9-dihe-na -77.2, 171.08 APE8-dihe-in -47.05, 145.36 APE8-rot-in 345.28 APE67-dihe-out 116.59, -10.88 85.51, 60.96 APE12-dist-in 12.8381 APE11-dist-in 13.2434 APE10-dist-out 9.3534 APE9-dist-in 3.5072 None None None XRAY 2.7 0.238 0.294 C 432.0 390.0 14 31 20 11 [[571, 832]] 1.0 3p23 OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 3P23D O75460 561 963 977.0 ADP:1002 ATPlike Inactive DFGin 7.4094 13.2631 BLBplus -138.88, 177.03 72.28, 10.83 -71.52, 154.68 50.97, 93.75 83.32, -17.5 out-out out 16.034 Saltbr-out 13.0181 HRD-in -58.06, -54.76 77.4, -2.34 out-out-out SNCooo out-out ActLoopNT-out 10.0574 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnoi APE10-dihe-na 999.0, 162.88 APE9-dihe-na -149.96, -140.99 APE8-dihe-in -73.3, 139.85 APE8-rot-in 325.01 APE67-dihe-out 115.82, -9.19 91.28, 60.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.1125 APE9-dist-in 4.0378 None None None XRAY 2.7 0.238 0.294 D 432.0 387.0 16 31 17 14 [[571, 832]] 1.0 3p23 OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER PIK3R4 PI3R4_HUMAN 8SORA Q99570 15 1358 1358.0 ADP:1401 ATPlike Pseudo DFGin 9.418 15.8103 BLBminus -148.68, -163.36 56.86, 40.25 -54.73, 139.1 286.63, 79.79 -95.49, 38.09 out-out out 17.8082 Saltbr-out 21.0895 HRD-in -78.26, -64.21 93.22, -18.74 out-out-out SNCooo out-out ActLoopNT-out 9.1206 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na 53.41, 44.04 APE9-dihe-na -115.24, -10.88 APE8-dihe-out 68.3, 15.78 APE8-rot-na 299.15 APE67-dihe-out -125.94, 101.57 -74.9, 135.12 APE12-dist-out 14.3019 APE11-dist-out 17.974 APE10-dist-out 21.0555 APE9-dist-out 15.9768 None None None EM 3.96 999.0 999.0 A 1358.0 1156.0 28 35 35 0 [[19, 321]] 1.0 8sor OTHER_PIK3R4_HUMAN PIK3R4 5.8e-151 507.9 1.0 298.0 298.0 165 166 167 169 171 53 73 77 145 147 146 148.0 240 200 195 194 193 192 191 190 189 104 Phosphoinositide 3-kinase regulatory subunit 4
OTHER RNASEL RN5A_HUMAN 4OAUC Q05823 25 719 741.0 ADP:801 ATPlike Pseudo DFGin 6.5293 12.3785 BLAminus -152.72, -178.03 59.98, 103.61 -125.32, 12.02 305.12, 98.0 -75.28, 8.76 in-in in 6.9931 Saltbr-in 2.6229 HRD-in -74.91, -47.94 67.23, 8.17 in-in-na SNCiia in-na ActLoopNT-in 2.9126 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -67.73, 111.98 APE9-dihe-na -66.2, -20.72 APE8-dihe-na -68.67, -28.85 APE8-rot-na 187.68 APE67-dihe-na -72.58, -38.81 -76.25, -36.54 APE12-dist-na 14.0675 APE11-dist-na 16.8747 APE10-dist-na 14.9848 APE9-dist-na 14.3331 H672N None None XRAY 2.6 0.213 0.251 C 699.0 692.0 0 20 20 0 [[353, 594]] 1.0 4oau OTHER_RNASEL_HUMAN RNASEL 4.1e-136 459.9 1.0 242.0 242.0 502 503 504 506 508 392 404 408 482 484 483 485.0 520 522 517 516 515 514 513 512 511 435 2-5A-dependent ribonuclease
STE MAP2K1 MP2K1_HUMAN 3EQIA Q02750 39 382 393.0 ADP:2 ATPlike Inactive DFGin 6.097 14.1456 BLBplus -145.58, 171.19 59.48, 41.15 -92.75, 128.75 41.67, 88.89 -58.7, 127.06 out-out out 15.2136 Saltbr-out 14.7281 HRD-in -57.14, -59.8 81.96, -12.14 out-out-out SNCooo out-out ActLoopNT-out 10.7022 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -160.04, 114.16 APE9-dihe-na -79.94, 159.35 APE8-dihe-in -52.77, 143.91 APE8-rot-out 201.8 APE67-dihe-in -60.21, -14.42 -106.05, 1.41 APE12-dist-out 20.1478 APE11-dist-out 15.2393 APE10-dist-out 17.2957 APE9-dist-out 9.228 S298N,S299K,Y300F None None XRAY 1.9 0.165 999.0 A 360.0 315.0 29 26 26 0 [[68, 361]] 1.0 3eqi STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3MBLA Q02750 62 381 393.0 ADP:60535,LSG:60007 ATPlike,Type3 Inactive DFGin 6.3443 13.4033 BLBplus -137.82, 175.17 58.41, 36.59 -88.68, 159.6 41.78, 90.19 -90.36, 101.21 out-out out 15.5918 Saltbr-out 16.0041 HRD-in -72.77, -61.87 90.83, -9.53 out-out-out SNCooo out-out ActLoopNT-out 9.7788 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -62.62, 116.57 APE9-dihe-na -76.67, -13.86 APE8-dihe-out -100.19, -102.3 APE8-rot-out 48.6 APE67-dihe-out -109.33, 135.36 -59.01, 126.17 APE12-dist-out 18.7047 APE11-dist-out 17.8806 APE10-dist-out 19.945 APE9-dist-out 14.4728 None None None XRAY 2.6 0.169 0.215 A 328.0 289.0 31 26 26 0 [[68, 361]] 1.0 3mbl STE_MAP2K1_HUMAN STE 1.3e-97 332.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4ARKA Q02750 62 382 393.0 ADP:61383,M3K:61385 ATPlike,Type3 Inactive DFGin 6.213 13.3205 BLBplus -143.7, -171.53 62.76, 23.96 -76.11, 159.51 42.79, 94.02 -85.45, 75.28 out-out out 15.3534 Saltbr-out 15.901 HRD-in -67.47, -65.14 92.89, -4.81 out-out-out SNCooo out-out ActLoopNT-out 9.3292 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -100.98, -15.83 APE9-dihe-na -32.88, 128.59 APE8-dihe-out -40.11, 20.06 APE8-rot-out 186.45 APE67-dihe-out -132.58, 138.09 -155.02, 124.88 APE12-dist-out 16.3492 APE11-dist-out 18.1392 APE10-dist-out 23.5537 APE9-dist-out 14.4262 None None None XRAY 2.6 0.174 0.211 A 341.0 290.0 31 26 26 0 [[68, 361]] 1.0 4ark STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3EQGA Q02750 39 381 393.0 ADP:2,4BM:1 ATPlike,Type3 Inactive DFGin 6.6055 13.7427 BLBplus -138.18, 179.2 59.31, 28.5 -81.55, 153.56 35.8, 92.23 -71.67, 64.14 out-out out 15.4736 Saltbr-out 14.5657 HRD-in -60.95, -65.33 94.63, -12.32 out-out-out SNCooo out-out ActLoopNT-out 9.2307 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -104.38, 152.44 APE9-dihe-na -137.47, 114.08 APE8-dihe-in -13.21, 123.19 APE8-rot-out 216.51 APE67-dihe-in -71.17, -7.71 -101.04, 15.41 APE12-dist-out 19.79 APE11-dist-out 16.5602 APE10-dist-out 18.8547 APE9-dist-out 9.489 S298N,S299K,Y300F None None XRAY 2.5 0.21 0.273 A 360.0 314.0 29 26 26 0 [[68, 361]] 1.0 3eqg STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 6NYBB Q02750 56 383 393.0 ADP:60601,LCJ:60901 ATPlike,Type3 Inactive DFGin 5.9588 14.0365 BLBplus -152.28, 170.52 57.47, 42.76 -92.93, 161.49 47.46, 85.53 -88.41, 68.49 out-out out 15.4696 Saltbr-out 17.6022 HRD-in -56.15, -54.04 65.39, 11.35 out-out-out SNCooo out-out ActLoopNT-out 8.2916 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -140.81, 127.27 APE9-dihe-na -93.66, 157.79 APE8-dihe-out -110.82, -26.16 APE8-rot-out 55.56 APE67-dihe-out -130.29, 148.43 -119.13, 133.87 APE12-dist-out 17.78 APE11-dist-out 18.3191 APE10-dist-out 22.3789 APE9-dist-out 12.1589 S218A,S222A None None EM 4.1 999.0 999.0 B 415.0 289.0 39 26 26 0 [[68, 361]] 1.0 6nyb STE_MAP2K1_HUMAN STE 1.3e-96 329.0 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3EQHA Q02750 39 381 393.0 5BM:1,ADP:2 Type3,ATPlike Inactive DFGin 6.8455 13.3483 BLBplus -141.56, 168.5 59.76, 36.07 -79.95, 154.58 28.74, 98.71 -78.77, 88.92 out-out out 15.2501 Saltbr-out 13.9257 HRD-in -70.86, -51.49 82.66, -16.34 out-out-out SNCooo out-out ActLoopNT-out 9.8448 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na 72.18, 69.91 APE9-dihe-na -156.93, 105.03 APE8-dihe-in -35.31, 137.66 APE8-rot-out 209.36 APE67-dihe-in -58.22, -17.3 -105.41, 1.3 APE12-dist-out 17.8887 APE11-dist-out 18.0239 APE10-dist-out 19.2755 APE9-dist-out 9.6547 S298N,S299K,Y300F None None XRAY 2.0 0.192 999.0 A 360.0 314.0 29 26 26 0 [[68, 361]] 1.0 3eqh STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE PAK3 PAK3_HUMAN 6FD3A O75914 261 556 559.0 ADP:60603 ATPlike Active DFGin 5.9519 14.1494 BLAminus -133.62, -174.01 64.9, 77.07 -96.85, 18.52 289.09, 83.73 -72.71, -11.5 in-in in 8.938 Saltbr-in 2.7609 HRD-in -71.32, -50.63 74.19, 1.63 in-in-in SNCiii in-in ActLoopNT-in 2.9127 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.75, 147.44 APE9-dihe-na 132.72, -161.48 APE8-dihe-in -114.41, 121.22 APE8-rot-in 305.33 APE67-dihe-in -64.48, -19.99 -44.4, -48.2 APE12-dist-in 8.8491 APE11-dist-in 11.3583 APE10-dist-in 5.5763 APE9-dist-in 3.3396 A537D None T8L436 XRAY 1.52 0.176 0.19 A 300.0 296.0 0 28 28 0 [[283, 534]] 1.0 6fd3 STE_PAK3_HUMAN STE 1.1e-94 322.5 1.0 257.0 257.0 419 420 421 423 425 312 328 332 399 401 400 402.0 459 447 442 441 440 439 438 437 436 358 Serine/threonine-protein kinase PAK 3
STE STK24 STK24_HUMAN 3A7JA Q9Y6E0 25 311 443.0 ADP:60500 ATPlike Active DFGin 6.7468 14.5829 BLAminus -138.67, 168.25 71.5, 79.52 -101.19, 20.06 287.01, 95.64 -64.31, -27.68 in-in in 8.5297 Saltbr-in 2.5524 HRD-in -69.86, -43.49 67.32, -1.05 in-in-in SNCiii in-in ActLoopNT-in 2.7408 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.28, 158.62 APE9-dihe-na 130.53, -164.99 APE8-dihe-in -116.23, 120.86 APE8-rot-in 304.02 APE67-dihe-in -60.63, -23.79 -34.15, -55.13 APE12-dist-in 8.2963 APE11-dist-in 11.1102 APE10-dist-in 5.251 APE9-dist-in 3.2876 None TPO190 TPO190 XRAY 1.5 0.191 0.21 A 303.0 287.0 0 28 28 0 [[36, 286]] 1.0 3a7j STE_STK24_HUMAN STE 3.6e-100 340.5 1.0 257.0 257.0 173 174 175 177 179 65 82 86 153 155 154 156.0 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4O27B Q9Y6E0 30 309 443.0 ADP:60500 ATPlike Inactive DFGin 4.8671 13.8197 None -148.38, -173.28 56.25, -124.14 31.74, 82.19 64.76, 101.5 98.89, -78.6 in-in in 8.9372 Saltbr-in 2.9006 HRD-in -80.55, -48.63 69.48, -10.03 in-in-out SNCiio in-out ActLoopNT-in 3.0174 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -123.0, 177.15 APE9-dihe-na 103.58, 170.34 APE8-dihe-in -99.19, 143.02 APE8-rot-out 34.53 APE67-dihe-in -72.39, -25.42 -54.44, -42.62 APE12-dist-in 9.0284 APE11-dist-in 10.879 APE10-dist-in 5.5618 APE9-dist-in 3.6436 T190E None None XRAY 3.185 0.203 0.26 B 281.0 280.0 0 28 28 0 [[36, 286]] 1.0 4o27 STE_STK24_HUMAN STE 5.5e-100 339.9 1.0 257.0 257.0 173 174 175 177 179 65 82 86 153 155 154 156.0 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STRADA STRAA_HUMAN 8VSUB Q7RTN6 60 401 431.0 ADP:2001 ATPlike Pseudo DFGin 5.3284 13.7435 None -141.72, 9.36 -84.56, 30.72 -65.1, -14.12 305.81, 3.72 -62.58, -31.2 out-none out 10.2295 Saltbr-none 999.0 HRD-out -66.66, 151.23 -136.62, 153.73 none-in-out SNCnio in-out ActLoopNT-in 2.8656 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_iooo APE10-dihe-na -55.51, -37.77 APE9-dihe-na -75.16, -6.37 APE8-dihe-out -108.58, -14.7 APE8-rot-na 180.94 APE67-dihe-in -58.61, -34.89 -50.23, -38.37 APE12-dist-in 8.3418 APE11-dist-out 7.821 APE10-dist-out 13.0573 APE9-dist-out 11.0521 None None None EM 2.86 999.0 999.0 B 429.0 306.0 36 35 35 0 [[69, 379]] 1.0 8vsu STE_STRADA_HUMAN STE 6.5e-87 297.3 1.0 257.0 257.0 212 213 214 216 218 100 118 122 192 194 193 195.0 261 247 242 241 240 239 238 237 236 148 STE20-related kinase adapter protein alpha
STE TAOK3 TAOK3_HUMAN 6BDNA Q9H2K8 8 314 898.0 ADP:404 ATPlike Active DFGin 6.771 13.8246 BLAminus -136.73, -179.28 62.01, 80.15 -97.31, 23.85 293.38, 102.08 -68.85, -11.35 in-in in 8.4853 Saltbr-in 2.6815 HRD-in -74.02, -52.69 74.7, -5.2 in-in-in SNCiii in-in ActLoopNT-in 2.7971 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.94, 158.28 APE9-dihe-na 130.64, -172.75 APE8-dihe-in -113.55, 120.19 APE8-rot-in 301.22 APE67-dihe-in -62.99, -26.26 -46.03, -46.8 APE12-dist-in 8.2804 APE11-dist-in 11.0397 APE10-dist-in 5.1803 APE9-dist-in 3.3832 R2A,K3A None None XRAY 1.5 0.187 0.214 A 320.0 307.0 0 24 24 0 [[24, 277]] 1.0 6bdn STE_TAOK3_HUMAN STE 6.3e-90 307.0 4.0 257.0 254.0 164 165 166 168 170 53 72 76 144 146 145 147.0 203 188 183 182 181 180 179 178 177 102 Serine/threonine-protein kinase TAO3
TKL BMPR2 BMPR2_HUMAN 3G2FA Q13873 197 510 1038.0 ADP:900 ATPlike Active DFGin 6.9573 13.9443 BLAminus -131.62, -179.2 66.08, 79.87 -102.79, 27.43 304.26, 96.52 -59.99, -25.3 in-in in 8.1073 Saltbr-in 2.7568 HRD-in -69.81, -50.66 82.19, -10.63 in-in-in SNCiii in-in ActLoopNT-in 2.9811 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.1, -22.11 APE9-dihe-na -73.96, -168.61 APE8-dihe-in -80.16, 127.03 APE8-rot-in 308.56 APE67-dihe-in -65.91, -22.58 -59.75, -41.5 APE12-dist-in 11.4026 APE11-dist-in 12.6299 APE10-dist-in 7.0259 APE9-dist-in 4.0326 None None CAS288,CAS397,CAS496 XRAY 2.35 0.21 0.246 A 336.0 305.0 9 36 27 9 [[202, 503]] 1.0 3g2f TKL_BMPR2_HUMAN TKL 1.4e-75 260.2 2.0 266.0 265.0 350 351 352 354 356 230 243 247 330 332 331 333.0 405 386 381 380 379 378 377 376 375 280 Bone morphogenetic protein receptor type-2
TKL BMPR2 BMPR2_HUMAN 3G2FB Q13873 198 513 1038.0 ADP:900 ATPlike Active DFGin 6.9679 14.0082 BLAminus -149.7, 179.95 61.07, 87.18 -102.54, 11.93 293.8, 112.47 -56.7, -17.91 in-in in 8.0646 Saltbr-in 2.7316 HRD-in -73.22, -52.25 87.7, -10.0 in-in-in SNCiii in-in ActLoopNT-in 2.9139 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.94, -26.41 APE9-dihe-na -71.73, -175.39 APE8-dihe-in -71.07, 133.08 APE8-rot-in 315.55 APE67-dihe-in -68.07, -13.93 -56.75, -42.89 APE12-dist-in 11.1939 APE11-dist-in 12.1078 APE10-dist-in 6.494 APE9-dist-in 3.7222 None None CAS288,CAS397,CAS496 XRAY 2.35 0.21 0.246 B 336.0 303.0 13 36 23 13 [[202, 503]] 1.0 3g2f TKL_BMPR2_HUMAN TKL 1.4e-75 260.2 2.0 266.0 265.0 350 351 352 354 356 230 243 247 330 332 331 333.0 405 386 381 380 379 378 377 376 375 280 Bone morphogenetic protein receptor type-2
TKL BMPR2 BMPR2_HUMAN 6UNPB Q13873 197 509 1038.0 ADP:601 ATPlike Active DFGin 6.9166 14.0508 BLAminus -140.56, 176.5 63.35, 76.41 -96.26, 25.8 302.12, 104.12 -61.08, -20.73 in-in in 7.9042 Saltbr-in 2.8646 HRD-in -75.95, -48.17 78.17, -6.91 in-in-in SNCiii in-in ActLoopNT-in 2.977 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.29, -9.38 APE9-dihe-na -69.43, -161.26 APE8-dihe-in -89.59, 127.34 APE8-rot-in 301.19 APE67-dihe-in -48.39, -33.11 -62.11, -43.63 APE12-dist-in 12.0086 APE11-dist-in 12.508 APE10-dist-in 7.0989 APE9-dist-in 4.016 D485G None CAS288,CAS397,CAS496 XRAY 2.3 0.19 0.211 B 363.0 303.0 10 36 28 8 [[202, 503]] 1.0 6unp TKL_BMPR2_HUMAN TKL 1.1e-74 257.3 2.0 266.0 265.0 350 351 352 354 356 230 243 247 330 332 331 333.0 405 386 381 380 379 378 377 376 375 280 Bone morphogenetic protein receptor type-2
TKL BMPR2 BMPR2_HUMAN 6UNPA Q13873 199 509 1038.0 ADP:601,ADP:602 ATPlike,Allosteric None DFGin 7.015 14.0658 BLAminus -140.5, 177.86 62.51, 75.21 -94.82, 26.77 301.08, 104.11 -62.66, -20.97 in-in in 7.9826 Saltbr-in 2.8316 HRD-in -73.31, -49.03 80.8, -8.07 in-in-none SNCiin in-none ActLoopNT-in 2.9199 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -134.35, -10.44 APE9-dihe-na -70.57, -158.87 APE8-dihe-in -91.29, 127.64 APE8-rot-in 299.54 APE67-dihe-in -49.77, -33.71 -61.84, -45.11 APE12-dist-none 999.0 APE11-dist-in 12.7405 APE10-dist-in 7.2841 APE9-dist-in 4.0925 D485G None CAS288,CAS397,CAS496 XRAY 2.3 0.19 0.211 A 363.0 302.0 9 36 27 9 [[202, 503]] 1.0 6unp TKL_BMPR2_HUMAN TKL 1.1e-74 257.3 2.0 266.0 265.0 350 351 352 354 356 230 243 247 330 332 331 333.0 405 386 381 380 379 378 377 376 375 280 Bone morphogenetic protein receptor type-2
TKL KSR2 KSR2_HUMAN 7JUQB Q6VAB6 652 932 950.0 ADP:1001 ATPlike Pseudo DFGin 5.7226 13.4298 BLBplus -139.35, 152.22 61.66, 33.54 -71.04, 141.2 52.07, 82.92 82.4, -21.94 out-none out 15.3893 Saltbr-none 999.0 HRD-in -71.47, -51.16 73.41, 1.02 none-out-out SNCnoo out-out ActLoopNT-out 7.4594 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -57.45, -45.23 APE9-dihe-na -90.48, -7.37 APE8-dihe-out -66.85, -54.6 APE8-rot-na 183.3 APE67-dihe-in -71.76, -8.04 -52.06, -44.72 APE12-dist-out 18.4872 APE11-dist-out 15.1028 APE10-dist-out 19.5188 APE9-dist-out 11.9629 None None None XRAY 3.22 0.256 0.288 B 342.0 277.0 4 33 30 3 [[665, 930]] 1.0 7juq TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2.0 267.0 266.0 802 803 804 806 808 692 710 714 783 785 784 786.0 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TYR ABL1 ABL1_HUMAN 2G2IA P00519 229 502 1130.0 ADP:820 ATPlike Inactive DFGin 6.6309 13.4329 BLAminus -148.4, 173.75 80.3, 76.24 -98.47, 37.85 308.34, 118.79 -64.97, -55.29 in-in in 8.0051 Saltbr-in 3.2474 HRD-out -103.94, 83.88 -55.25, 17.72 in-in-in SNCiii in-in ActLoopNT-in 3.0637 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -140.34, 116.79 APE9-dihe-in -127.46, 160.87 APE8-dihe-in -56.61, 91.87 APE8-rot-na 28.18 APE67-dihe-in -56.4, -10.87 -40.77, -65.33 APE12-dist-na 14.9044 APE11-dist-na 10.5735 APE10-dist-na 12.836 APE9-dist-in 7.3096 H396P None None XRAY 3.12 0.251 0.308 A 287.0 271.0 3 29 29 0 [[242, 495]] 1.0 2g2i TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2G2IB P00519 232 500 1130.0 ADP:821 ATPlike Inactive DFGin 6.6234 13.7447 BLAminus -144.73, -170.13 58.63, 49.5 -73.16, 23.66 306.98, 113.05 -58.19, -50.38 in-in in 7.7947 Saltbr-in 2.8716 HRD-out -111.21, 97.67 -66.16, -14.66 in-in-in SNCiii in-in ActLoopNT-in 3.4038 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.86, 132.09 APE9-dihe-in -111.79, 159.65 APE8-dihe-in -83.23, 82.29 APE8-rot-na 32.48 APE67-dihe-in -53.07, -28.27 -29.82, -59.17 APE12-dist-na 14.9753 APE11-dist-na 10.3404 APE10-dist-na 12.8288 APE9-dist-in 7.6248 H396P None None XRAY 3.12 0.251 0.308 B 287.0 265.0 4 29 29 0 [[242, 495]] 1.0 2g2i TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ALK ALK_HUMAN 3LCTA Q9UM73 1093 1400 1620.0 ADP:1412 ATPlike Inactive DFGin 6.2665 15.1932 ABAminus -127.22, 10.26 -136.37, 129.73 -130.23, 18.7 291.41, 88.16 -49.74, -46.74 in-none in 8.1003 Saltbr-none 999.0 HRD-in -78.72, -45.58 81.21, -3.39 none-out-out SNCnoo out-out ActLoopNT-out 6.8864 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -94.62, -10.42 APE9-dihe-in -67.88, 140.77 APE8-dihe-in -81.63, 62.42 APE8-rot-na 34.08 APE67-dihe-in -66.16, -16.53 -61.79, -27.56 APE12-dist-na 14.7391 APE11-dist-na 15.1116 APE10-dist-na 9.9808 APE9-dist-out 8.0309 S1281G None None XRAY 2.1 0.207 0.255 A 344.0 308.0 0 30 30 0 [[1116, 1385]] 1.0 3lct TYR_ALK_HUMAN TYR 5e-90 307.3 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR EGFR EGFR_HUMAN 4RIWB P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.9474 14.5093 None -144.94, -140.84 60.54, -94.56 67.75, 16.38 293.55, 125.63 -72.75, -24.64 in-in in 8.962 Saltbr-in 2.5768 HRD-out -81.5, 87.13 -71.92, 10.44 in-in-none SNCiin in-none ActLoopNT-in 2.9141 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.11 APE8-dihe-in -64.72, 105.47 APE8-rot-na 338.81 APE67-dihe-in -78.09, 0.73 -66.98, -35.92 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.3389 V948R,F997A,L1001A None None XRAY 3.1 0.233 0.287 B 345.0 293.0 4 30 26 4 [[712, 970]] 1.0 4riw TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIWD P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 6.0156 14.3995 None -147.43, -141.55 60.24, -94.38 68.1, 17.38 294.17, 126.48 -72.23, -23.22 in-in in 8.8454 Saltbr-in 3.0814 HRD-in -78.23, -46.1 60.09, 5.38 in-in-in SNCiii in-in ActLoopNT-in 2.84 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.64, 111.47 APE9-dihe-in -129.74, 134.09 APE8-dihe-in -62.84, 106.17 APE8-rot-na 337.89 APE67-dihe-in -78.37, 3.33 -65.15, -34.97 APE12-dist-na 11.3973 APE11-dist-na 9.9458 APE10-dist-na 9.7227 APE9-dist-in 6.0148 V948R,F997A,L1001A None None XRAY 3.1 0.233 0.287 D 345.0 297.0 0 30 30 0 [[712, 970]] 1.0 4riw TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIXB P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.9187 14.5792 None -139.87, -153.46 71.8, -106.42 74.55, 12.91 300.13, 117.16 -73.01, -18.89 in-in in 8.7784 Saltbr-in 2.8507 HRD-out -79.93, 91.22 -73.37, 9.67 in-in-none SNCiin in-none ActLoopNT-in 2.815 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.04 APE8-dihe-in -57.54, 105.82 APE8-rot-na 336.15 APE67-dihe-in -83.65, 5.55 -71.82, -34.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.6445 V948R,F997A,L1001A None None XRAY 3.1 0.21 0.258 B 345.0 293.0 4 30 26 4 [[712, 970]] 1.0 4rix TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIXD P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.9838 14.3961 None -138.76, -155.76 70.86, -102.17 73.98, 14.44 299.1, 114.44 -71.0, -18.03 in-in in 8.4327 Saltbr-in 2.1297 HRD-in -75.74, -46.31 59.89, 5.04 in-in-in SNCiii in-in ActLoopNT-in 2.8788 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.43, 115.77 APE9-dihe-in -128.43, 136.25 APE8-dihe-in -57.6, 106.59 APE8-rot-na 335.5 APE67-dihe-in -81.04, 4.3 -70.58, -32.32 APE12-dist-na 11.3356 APE11-dist-na 10.1436 APE10-dist-na 10.4275 APE9-dist-in 5.9873 V948R,F997A,L1001A None None XRAY 3.1 0.21 0.258 D 345.0 297.0 0 30 30 0 [[712, 970]] 1.0 4rix TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIYB P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.9519 14.6551 None -154.99, 131.23 -173.19, -76.87 64.96, 12.46 300.69, 132.23 -71.94, -28.32 in-in in 8.6852 Saltbr-in 2.9501 HRD-out -79.99, 96.69 -77.78, 9.7 in-in-none SNCiin in-none ActLoopNT-in 2.8837 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.59 APE8-dihe-in -76.15, 93.2 APE8-rot-na 346.43 APE67-dihe-in -79.33, 6.83 -64.49, -46.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.3497 V948R,F997A,L1001A None None XRAY 2.981 0.221 0.267 B 345.0 293.0 4 30 26 4 [[712, 970]] 1.0 4riy TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIYD P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.8922 14.3982 None -146.72, -160.68 90.34, -82.61 63.94, 14.36 297.22, 112.71 -69.53, -27.12 in-in in 8.3332 Saltbr-in 2.3271 HRD-in -73.91, -45.57 61.02, 4.8 in-in-in SNCiii in-in ActLoopNT-in 2.9763 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.34, 113.28 APE9-dihe-in -130.38, 137.58 APE8-dihe-in -69.37, 99.85 APE8-rot-na 344.82 APE67-dihe-in -75.56, 6.57 -58.1, -42.52 APE12-dist-na 11.2323 APE11-dist-na 10.2008 APE10-dist-na 9.9606 APE9-dist-in 6.2575 V948R,F997A,L1001A None None XRAY 2.981 0.221 0.267 D 345.0 297.0 0 30 30 0 [[712, 970]] 1.0 4riy TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EPHB1 EPHB1_HUMAN 7KPMA P54762 611 888 984.0 ADP:901 ATPlike Inactive DFGin 6.1477 15.077 None -129.01, -161.15 68.81, 56.56 -103.91, 999.0 293.32, 103.77 999.0, 999.0 in-in in 7.7435 Saltbr-in 2.7086 HRD-in -77.02, -45.59 75.58, -13.35 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 76.94 APE8-rot-na 30.04 APE67-dihe-in -77.93, -6.39 -53.89, -41.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None PTR647 PTR647 XRAY 1.608 0.169 0.197 A 279.0 255.0 23 33 10 23 [[619, 880]] 1.0 7kpm TYR_EPHB1_HUMAN TYR 2.3e-109 370.6 2.0 261.0 260.0 761 762 763 765 767 651 668 672 741 743 742 744.0 806 794 789 788 787 786 785 784 783 698 Ephrin type-B receptor 1
TYR ITK ITK_HUMAN 4M15A Q08881 355 617 620.0 QWS:701,ADP:702 Type3,ATPlike Inactive DFGin 7.9386 15.2905 BLBplus -140.12, 163.53 73.68, 16.28 -64.43, 134.2 34.87, 95.02 79.06, -6.9 out-out out 17.0659 Saltbr-out 16.2542 HRD-in -70.42, -53.15 83.67, -22.02 out-out-out SNCooo out-out ActLoopNT-out 7.7398 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -106.59, 12.56 APE9-dihe-in -62.84, 135.73 APE8-dihe-in -75.4, 60.83 APE8-rot-na 30.68 APE67-dihe-in -61.26, -23.89 -55.9, -32.96 APE12-dist-na 16.8357 APE11-dist-na 19.5146 APE10-dist-na 14.7845 APE9-dist-out 9.1517 None None None XRAY 1.52 0.172 0.186 A 269.0 263.0 0 29 29 0 [[363, 614]] 1.0 4m15 TYR_ITK_HUMAN TYR 1.2e-92 315.8 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR JAK1-2 JAK1_HUMAN 5KHWA P23458 867 1153 1154.0 ADP:1201 ATPlike Inactive DFGin 6.2929 13.5952 ABAminus -113.62, -36.19 -113.51, 112.49 -104.48, 28.51 302.05, 98.46 -68.45, -35.55 in-in in 8.0172 Saltbr-in 2.8107 HRD-in -53.69, -54.55 74.32, 4.71 in-in-in SNCiii in-in ActLoopNT-in 2.8167 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.25, 151.86 APE9-dihe-in -139.19, 145.92 APE8-dihe-in -78.07, 75.73 APE8-rot-na 29.65 APE67-dihe-in -77.72, -3.4 -55.44, -31.5 APE12-dist-na 13.0141 APE11-dist-na 7.3323 APE10-dist-na 9.9045 APE9-dist-in 6.0223 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.47 0.188 0.231 A 316.0 278.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 5khw TYR_JAK1-2_HUMAN TYR 2.6e-87 298.4 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
TYR JAK1-2 JAK1_HUMAN 6C7YA P23458 869 1153 1154.0 ADP:61201 ATPlike Active DFGin 6.0323 13.967 BLAminus -134.15, -164.18 58.49, 84.96 -109.28, 28.04 298.78, 97.45 -66.39, -27.05 in-in in 8.3107 Saltbr-in 2.7325 HRD-in -67.59, -46.53 68.25, 12.43 in-in-in SNCiii in-in ActLoopNT-in 2.9437 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.91, 151.36 APE9-dihe-in -137.76, 143.32 APE8-dihe-in -74.71, 81.76 APE8-rot-na 30.49 APE67-dihe-in -79.4, -2.38 -65.2, -24.66 APE12-dist-na 12.9717 APE11-dist-na 8.0201 APE10-dist-na 10.3436 APE9-dist-in 6.3164 None PTR1035 PTR1035 XRAY 2.499 0.21 0.241 A 286.0 273.0 12 31 31 0 [[583, 847], [875, 1151]] 2.0 6c7y TYR_JAK1-2_HUMAN TYR 1.8e-87 298.9 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
TYR JAK1-2 JAK1_HUMAN 5KHWB P23458 867 1153 1154.0 ADP:1201 ATPlike Inactive DFGin 6.1878 13.7874 BLAminus -126.62, -174.05 50.66, 92.23 -105.71, 28.99 301.42, 97.18 -62.73, -33.32 in-in in 7.9908 Saltbr-in 2.817 HRD-in -54.38, -55.02 75.74, 4.0 in-in-out SNCiio in-out ActLoopNT-in 2.8112 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -83.14, 18.97 APE9-dihe-in -58.32, 113.18 APE8-dihe-in -82.04, 77.86 APE8-rot-na 28.29 APE67-dihe-in -76.85, -3.42 -56.14, -32.61 APE12-dist-na 7.879 APE11-dist-na 9.6953 APE10-dist-na 6.6047 APE9-dist-in 5.9119 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.47 0.188 0.231 B 316.0 278.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 5khw TYR_JAK1-2_HUMAN TYR 2.6e-87 298.4 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
TYR KIT KIT_HUMAN 1PKGA P10721 567 927 976.0 ADP:1480 ATPlike Inactive DFGin 6.4807 14.1365 BLAminus -130.56, -161.98 47.26, 79.76 -98.59, 34.29 290.92, 88.36 -71.71, -28.0 in-out in 8.1383 Saltbr-out 3.8827 HRD-in -70.61, -44.29 71.47, -6.33 out-in-out SNCoio in-out ActLoopNT-in 2.9813 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 81.05, 87.98 APE9-dihe-in -123.34, 167.37 APE8-dihe-in -84.87, 64.98 APE8-rot-na 27.08 APE67-dihe-in -64.22, -13.25 -46.84, -45.75 APE12-dist-na 14.8174 APE11-dist-na 9.099 APE10-dist-na 11.173 APE9-dist-in 6.8945 None PTR568,PTR570 PTR568,PTR570 XRAY 2.9 0.229 0.311 A 329.0 292.0 11 30 30 0 [[589, 926]] 1.0 1pkg TYR_KIT_HUMAN TYR 4.5e-102 346.9 1.0 260.0 260.0 809 810 811 813 815 623 640 644 789 791 790 792.0 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 1PKGB P10721 566 929 976.0 ADP:1486 ATPlike None DFGin 6.5368 13.8185 BLAminus -133.94, -165.75 57.9, 93.59 -119.64, 36.22 290.23, 87.19 -80.39, -20.36 in-in in 6.9344 Saltbr-in 2.9154 HRD-in -72.14, -51.55 69.69, 17.19 in-in-none SNCiin in-none ActLoopNT-in 2.8877 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 110.55 APE9-dihe-in -141.29, 162.93 APE8-dihe-in -80.26, 78.25 APE8-rot-na 29.66 APE67-dihe-in -62.74, -24.13 -40.98, -43.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.7652 APE9-dist-in 6.4939 None PTR568,PTR570 PTR568,PTR570 XRAY 2.9 0.229 0.311 B 329.0 279.0 27 30 17 13 [[589, 926]] 1.0 1pkg TYR_KIT_HUMAN TYR 4.5e-102 346.9 1.0 260.0 260.0 809 810 811 813 815 623 640 644 789 791 790 792.0 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR MERTK MERTK_HUMAN 3BRBA Q12866 575 861 999.0 ADP:901 ATPlike Inactive DFGin 6.074 13.6091 BLBplus -149.4, 172.79 64.51, 33.37 -100.26, 164.7 46.71, 83.96 59.32, 174.03 out-out out 13.7503 Saltbr-out 12.5583 HRD-in -82.25, -54.47 71.68, 7.51 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -42.31 APE8-dihe-in -85.78, 61.15 APE8-rot-na 26.09 APE67-dihe-in -74.59, -1.92 -45.39, -40.65 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.3414 None None None XRAY 1.9 0.195 0.24 A 313.0 260.0 27 30 14 16 [[587, 856]] 1.0 3brb TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 3BRBB Q12866 575 863 999.0 ADP:901 ATPlike Inactive DFGin 5.8744 13.3725 BLBplus -148.45, 175.8 65.39, 30.29 -97.01, 161.01 52.76, 80.7 77.95, 168.41 out-out out 13.6964 Saltbr-out 12.5721 HRD-in -83.14, -55.33 72.79, 2.25 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.74 APE8-rot-na 30.57 APE67-dihe-in -72.04, -6.33 -47.66, -41.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.195 0.24 B 313.0 271.0 18 30 12 18 [[587, 856]] 1.0 3brb TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR PTK2 FAK1_HUMAN 2IJMB Q05397 414 689 1052.0 ADP:800 ATPlike Inactive DFGin 6.3234 15.4927 BLBminus -110.71, -163.98 67.21, 81.0 -117.82, 145.96 283.77, 97.43 -64.08, -51.52 in-out in 7.6478 Saltbr-out 3.6757 HRD-in -77.75, -52.2 82.75, -4.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -36.05 APE8-dihe-out -75.82, 46.85 APE8-rot-na 30.48 APE67-dihe-in -72.2, -5.65 -47.65, -46.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.6994 None None None XRAY 2.187 0.211 0.271 B 281.0 261.0 15 29 14 15 [[422, 678]] 1.0 2ijm TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 1MP8A Q05397 414 686 1052.0 ADP:800 ATPlike Inactive None 999.0 999.0 None -89.07, -172.44 90.39, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 7.4463 Saltbr-in 3.0967 HRD-in -74.41, -44.19 70.37, -1.26 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.38 APE8-dihe-in -79.05, 61.98 APE8-rot-na 29.35 APE67-dihe-in -62.59, -13.79 -46.47, -46.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.0702 None None None XRAY 1.6 0.188 0.23 A 281.0 252.0 21 29 10 19 [[422, 678]] 1.0 1mp8 TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR TYK2-2 TYK2_HUMAN 4GVJA P29597 889 1176 1187.0 ADP:61201 ATPlike Inactive DFGin 6.2651 13.7524 BLAminus -124.99, -169.67 58.4, 84.34 -100.6, 24.1 294.23, 90.13 -57.35, -28.35 in-in in 8.284 Saltbr-in 2.6985 HRD-in -78.85, -48.62 71.47, -0.89 in-in-out SNCiio in-out ActLoopNT-in 2.8421 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -90.25, 6.85 APE9-dihe-in -64.48, 128.39 APE8-dihe-in -76.05, 68.17 APE8-rot-na 27.93 APE67-dihe-in -72.65, -6.35 -49.95, -35.24 APE12-dist-na 9.9682 APE11-dist-na 13.0361 APE10-dist-na 9.6495 APE9-dist-in 6.8446 C936A,Q969A,E971A,K972A,C1142A None None XRAY 2.03 0.19 0.231 A 302.0 288.0 0 31 31 0 [[589, 868], [897, 1171]] 2.0 4gvj TYR_TYK2-2_HUMAN TYR 9.4e-82 280.2 2.0 260.0 259.0 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023.0 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2

Ligand: ADP

Total number of chains: 317
Active chains: 117
Total number of genes: 75
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 239 75.4% 6YZHA
DFGin BLBplus 31 9.8% 4M15A
DFGin None 17 5.4% 5GZAA
None None 11 3.5% 4IX4A
DFGin ABAminus 10 3.2% 3LCTA
DFGin BLBminus 5 1.6% 5M06B
DFGinter None 4 1.3% 5L8LA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL BRI1 BRI1_ARATH 5LPBA O22476 867 1160 1196.0 ADP:1201 ATPlike Active DFGin 5.075 15.0582 BLAminus -134.68, 179.03 63.17, 81.59 -99.15, 20.06 285.86, 73.26 -60.78, -23.17 in-in in 8.6491 Saltbr-in 3.1477 HRD-in -69.16, -46.8 71.42, -2.74 in-in-in SNCiii in-in ActLoopNT-in 2.9288 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -107.78, 147.47 APE9-dihe-na 145.38, -170.04 APE8-dihe-in -133.78, 133.64 APE8-rot-in 306.07 APE67-dihe-inflip 102.35, -15.45 -46.22, 126.04 APE12-dist-in 9.2481 APE11-dist-in 11.2752 APE10-dist-in 5.4965 APE9-dist-in 3.7428 T872A TPO1039,SEP1042,SEP1044,SEP1060 TPO1039,SEP1042,SEP1044,SEP1060 XRAY 1.98 0.184 0.203 A 296.0 284.0 10 30 30 0 [[882, 1157]] 1.0 5lpb Arabidopsis thaliana TKL_BRI1_ARATH TKL 2e-63 220.4 4.0 266.0 263.0 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009.0 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL BRI1 BRI1_ARATH 5LPZA O22476 866 1160 1196.0 ADP:1200 ATPlike Active DFGin 5.2809 15.2287 BLAminus -133.61, -178.19 59.45, 71.09 -88.15, 19.11 288.53, 76.38 -60.79, -23.86 in-in in 8.6333 Saltbr-in 2.8287 HRD-in -68.17, -37.55 64.9, -2.92 in-in-in SNCiii in-in ActLoopNT-in 3.0224 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -69.74, 170.98 APE9-dihe-na 106.33, 162.6 APE8-dihe-in -102.72, 137.46 APE8-rot-in 305.68 APE67-dihe-inflip 102.78, -18.56 -57.05, 134.59 APE12-dist-in 9.3424 APE11-dist-in 11.7555 APE10-dist-in 5.7196 APE9-dist-in 3.5785 T872A TPO1039,SEP1042,SEP1044 TPO1039,SEP1042,SEP1044 XRAY 2.48 0.226 0.253 A 332.0 286.0 9 30 30 0 [[882, 1157]] 1.0 5lpz Arabidopsis thaliana TKL_BRI1_ARATH TKL 3e-63 219.9 4.0 266.0 263.0 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009.0 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL FERONIA FERON_ARATH 7XDXA Q9SCZ4 521 815 895.0 ADP:901 ATPlike Inactive DFGin 6.8683 15.5083 BLAminus -133.42, -178.74 67.64, 77.46 -97.26, 15.76 285.98, 88.34 -59.81, -31.94 in-out in 8.7215 Saltbr-out 5.533 HRD-in -65.25, -47.87 74.08, 0.6 out-in-none SNCoin in-none ActLoopNT-in 2.7617 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 135.64 APE8-rot-in 306.33 APE67-dihe-inflip 94.97, -23.67 -64.5, 138.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.23 0.184 0.235 A 313.0 280.0 15 30 15 15 [[535, 809]] 1.0 7xdx Arabidopsis thaliana TKL_FERONIA_ARATH TKL 2e-57 200.7 3.0 266.0 264.0 678 679 680 682 684 565 581 585 658 660 659 661.0 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
TKL FERONIA FERON_ARATH 7XDXB Q9SCZ4 521 815 895.0 ADP:901 ATPlike None DFGin 6.6219 15.4249 BLAminus -136.76, -177.06 63.7, 79.87 -96.73, 14.62 285.92, 71.87 -59.53, -21.5 in-in in 8.5759 Saltbr-in 3.3322 HRD-in -65.1, -49.82 75.49, 1.86 in-in-none SNCiin in-none ActLoopNT-in 2.7369 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 136.01 APE8-rot-in 320.81 APE67-dihe-inflip 95.62, -22.56 -64.49, 139.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.23 0.184 0.235 B 313.0 280.0 15 30 15 15 [[535, 809]] 1.0 7xdx Arabidopsis thaliana TKL_FERONIA_ARATH TKL 2e-57 200.7 3.0 266.0 264.0 678 679 680 682 684 565 581 585 658 660 659 661.0 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
TKL FERONIA FERON_ARATH 7XDYA Q9SCZ4 521 815 895.0 ADP:901 ATPlike Inactive DFGin 6.7592 15.7857 BLAminus -141.78, -171.91 66.87, 59.86 -83.38, 11.19 284.91, 77.98 -59.88, -27.32 in-out in 8.8858 Saltbr-out 5.6045 HRD-in -63.61, -43.27 68.91, 0.58 out-in-none SNCoin in-none ActLoopNT-in 2.8628 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 155.73 APE8-rot-in 307.09 APE67-dihe-inflip 97.81, -22.04 -77.29, 136.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.28 0.2 0.247 A 313.0 280.0 15 30 15 15 [[535, 809]] 1.0 7xdy Arabidopsis thaliana TKL_FERONIA_ARATH TKL 2e-57 200.7 3.0 266.0 264.0 678 679 680 682 684 565 581 585 658 660 659 661.0 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
TKL FERONIA FERON_ARATH 7XDYB Q9SCZ4 522 816 895.0 ADP:901 ATPlike Inactive DFGin 6.4485 16.0333 BLAminus -144.23, -178.13 65.87, 74.19 -94.93, 27.11 292.01, 67.35 -65.38, -32.71 in-out in 9.3487 Saltbr-out 6.0788 HRD-in -72.36, -52.52 79.98, -11.0 out-in-out SNCoio in-out ActLoopNT-in 2.784 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -15.92 APE8-rot-out 172.5 APE67-dihe-in -79.26, 18.24 -58.71, -66.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.28 0.2 0.247 B 313.0 280.0 15 30 15 15 [[535, 809]] 1.0 7xdy Arabidopsis thaliana TKL_FERONIA_ARATH TKL 2e-57 200.7 3.0 266.0 264.0 678 679 680 682 684 565 581 585 658 660 659 661.0 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
TKL FERONIA FERON_ARATH 7XDWA Q9SCZ4 521 815 895.0 ADP:901 ATPlike None DFGin 6.7365 15.7469 BLAminus -137.39, -174.63 58.35, 60.55 -84.66, 26.98 279.96, 82.38 -74.32, -25.62 in-none in 8.7321 Saltbr-none 999.0 HRD-in -69.86, -44.55 71.98, 2.17 none-in-none SNCnin in-none ActLoopNT-in 2.918 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 144.08 APE8-rot-in 320.64 APE67-dihe-in -58.47, -9.87 -56.6, -62.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.926 0.188 0.207 A 313.0 281.0 14 30 16 14 [[535, 809]] 1.0 7xdw Arabidopsis thaliana TKL_FERONIA_ARATH TKL 8.2e-57 198.7 3.0 266.0 264.0 678 679 680 682 684 565 581 585 658 660 659 661.0 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
TKL FERONIA FERON_ARATH 7XDWB Q9SCZ4 522 816 895.0 ADP:901 ATPlike None DFGin 6.7079 15.5191 BLAminus -137.44, -171.65 65.06, 59.01 -87.27, 21.93 280.32, 83.86 -70.86, -24.01 in-none in 8.7017 Saltbr-none 999.0 HRD-in -70.0, -44.65 71.38, 1.15 none-in-none SNCnin in-none ActLoopNT-in 2.9442 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 146.34 APE8-rot-in 314.87 APE67-dihe-inflip 95.5, -19.53 -58.77, 130.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.926 0.188 0.207 B 313.0 281.0 14 30 16 14 [[535, 809]] 1.0 7xdw Arabidopsis thaliana TKL_FERONIA_ARATH TKL 8.2e-57 198.7 3.0 266.0 264.0 678 679 680 682 684 565 581 585 658 660 659 661.0 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
AGC GRK1 GRK1_BOVIN 3C4ZA P28327 31 533 561.0 ADP:562 ATPlike Active DFGin 5.9128 13.2351 BLAminus -149.46, 171.26 70.91, 78.39 -108.02, 16.47 270.55, 111.24 -69.43, -16.01 in-in in 8.7363 Saltbr-in 2.7164 HRD-in -71.08, -53.07 69.31, 6.53 in-in-in SNCiii in-in ActLoopNT-in 2.8781 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.53, 147.45 APE9-dihe-na 134.96, -165.72 APE8-dihe-in -111.39, 128.56 APE8-rot-in 296.58 APE67-dihe-inflip 96.79, -17.75 -54.96, 131.39 APE12-dist-in 10.4298 APE11-dist-in 11.1131 APE10-dist-in 5.4905 APE9-dist-in 3.5422 None None None XRAY 1.84 0.193 999.0 A 543.0 493.0 0 28 28 0 [[187, 452]] 1.0 3c4z Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4.0 260.0 257.0 331 332 333 335 337 216 235 239 311 313 312 314.0 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C50A P28327 30 533 561.0 ADP:562 ATPlike Active DFGin 6.0752 13.0339 BLAminus -142.59, 172.43 68.85, 78.38 -104.12, 14.36 280.99, 104.76 -67.57, -15.07 in-in in 8.6024 Saltbr-in 2.9252 HRD-in -76.21, -52.36 64.46, 15.62 in-in-in SNCiii in-in ActLoopNT-in 2.7949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.66, 144.27 APE9-dihe-na 130.37, -165.26 APE8-dihe-in -104.68, 131.22 APE8-rot-in 300.48 APE67-dihe-inflip 92.29, -6.18 -56.88, 135.03 APE12-dist-in 10.685 APE11-dist-in 11.4689 APE10-dist-in 5.8763 APE9-dist-in 3.4729 None None None XRAY 2.6 0.19 999.0 A 543.0 499.0 0 28 28 0 [[187, 452]] 1.0 3c50 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4.0 260.0 257.0 331 332 333 335 337 216 235 239 311 313 312 314.0 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C50B P28327 30 533 561.0 ADP:562 ATPlike Active DFGin 6.0782 13.0677 BLAminus -140.52, 175.4 66.53, 77.05 -104.14, 18.55 279.39, 103.87 -67.23, -21.39 in-in in 8.5322 Saltbr-in 2.7211 HRD-in -71.74, -52.34 63.89, 11.32 in-in-in SNCiii in-in ActLoopNT-in 2.8901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.47, 143.37 APE9-dihe-na 137.53, -168.17 APE8-dihe-in -105.39, 125.32 APE8-rot-in 297.12 APE67-dihe-inflip 95.82, -17.57 -51.32, 135.4 APE12-dist-in 10.1294 APE11-dist-in 11.1147 APE10-dist-in 5.5383 APE9-dist-in 3.4184 None None None XRAY 2.6 0.19 999.0 B 543.0 496.0 0 28 28 0 [[187, 452]] 1.0 3c50 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4.0 260.0 257.0 331 332 333 335 337 216 235 239 311 313 312 314.0 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C51A P28327 31 533 561.0 ADP:562 ATPlike Active DFGin 5.7354 13.2354 BLAminus -156.28, 178.74 57.85, 73.51 -84.14, -2.01 283.03, 106.57 -47.35, -22.99 in-in in 8.7977 Saltbr-in 2.6866 HRD-in -64.41, -45.82 69.5, -19.46 in-in-in SNCiii in-in ActLoopNT-in 2.9155 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -176.64, 142.5 APE9-dihe-na 155.52, -169.52 APE8-dihe-in -101.5, 135.25 APE8-rot-in 300.99 APE67-dihe-inflip 84.91, 4.53 -59.96, 128.0 APE12-dist-in 10.573 APE11-dist-in 11.5413 APE10-dist-in 6.1515 APE9-dist-in 3.937 None None None XRAY 3.55 0.281 999.0 A 543.0 487.0 0 28 28 0 [[187, 452]] 1.0 3c51 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4.0 260.0 257.0 331 332 333 335 337 216 235 239 311 313 312 314.0 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C51B P28327 31 533 561.0 ADP:562 ATPlike Active DFGin 5.7851 13.1869 BLAminus -156.29, 175.57 58.57, 74.43 -85.29, -1.69 285.99, 107.07 -47.38, -22.91 in-in in 8.696 Saltbr-in 2.7915 HRD-in -66.67, -42.5 63.68, -15.39 in-in-in SNCiii in-in ActLoopNT-in 2.9686 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -176.05, 141.93 APE9-dihe-na 155.26, -171.96 APE8-dihe-in -101.33, 138.35 APE8-rot-in 299.85 APE67-dihe-inflip 84.6, 5.24 -64.39, 128.67 APE12-dist-in 10.5371 APE11-dist-in 11.5977 APE10-dist-in 6.1564 APE9-dist-in 3.9396 None None None XRAY 3.55 0.281 999.0 B 543.0 461.0 20 28 28 0 [[187, 452]] 1.0 3c51 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4.0 260.0 257.0 331 332 333 335 337 216 235 239 311 313 312 314.0 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3QC9A P28327 31 533 561.0 ADP:700 ATPlike Active DFGin 6.8516 13.4841 BLAminus -151.04, 174.48 70.22, 99.25 -129.57, 18.73 275.22, 99.19 -61.63, -18.96 in-in in 8.9606 Saltbr-in 3.1273 HRD-in -61.98, -58.15 73.37, -3.42 in-in-in SNCiii in-in ActLoopNT-in 2.9166 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -167.32, 133.82 APE9-dihe-na 142.48, -169.15 APE8-dihe-in -104.33, 125.71 APE8-rot-in 302.67 APE67-dihe-inflip 104.42, -3.83 -50.74, 122.55 APE12-dist-in 10.3557 APE11-dist-in 11.0144 APE10-dist-in 5.5004 APE9-dist-in 3.6645 T8C,N480C None None XRAY 2.7 0.194 0.229 A 543.0 486.0 0 28 28 0 [[187, 452]] 1.0 3qc9 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4.0 260.0 257.0 331 332 333 335 337 216 235 239 311 313 312 314.0 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3QC9B P28327 31 533 561.0 ADP:700 ATPlike Active DFGin 6.8991 13.5043 BLAminus -154.17, 173.67 70.5, 100.81 -132.54, 18.75 276.87, 97.69 -56.57, -24.02 in-in in 8.931 Saltbr-in 3.099 HRD-in -65.24, -58.34 73.4, -2.88 in-in-in SNCiii in-in ActLoopNT-in 2.9339 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -166.53, 132.45 APE9-dihe-na 145.72, -169.79 APE8-dihe-in -103.09, 126.5 APE8-rot-in 303.38 APE67-dihe-inflip 99.94, -4.73 -52.12, 123.93 APE12-dist-in 10.3676 APE11-dist-in 11.0383 APE10-dist-in 5.525 APE9-dist-in 3.6772 T8C,N480C None None XRAY 2.7 0.194 0.229 B 543.0 481.0 0 28 28 0 [[187, 452]] 1.0 3qc9 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4.0 260.0 257.0 331 332 333 335 337 216 235 239 311 313 312 314.0 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3QC9C P28327 31 533 561.0 ADP:700 ATPlike Active DFGin 6.8677 13.481 BLAminus -151.87, 172.48 72.03, 98.62 -128.19, 19.72 276.34, 98.38 -59.47, -19.79 in-in in 8.9508 Saltbr-in 3.1074 HRD-in -62.09, -58.44 72.04, -1.68 in-in-in SNCiii in-in ActLoopNT-in 2.9357 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -168.26, 134.05 APE9-dihe-na 142.83, -170.11 APE8-dihe-in -104.04, 126.58 APE8-rot-in 301.36 APE67-dihe-inflip 105.14, -2.81 -49.9, 120.73 APE12-dist-in 10.3838 APE11-dist-in 11.0185 APE10-dist-in 5.5081 APE9-dist-in 3.673 T8C,N480C None None XRAY 2.7 0.194 0.229 C 543.0 482.0 0 28 28 0 [[187, 452]] 1.0 3qc9 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4.0 260.0 257.0 331 332 333 335 337 216 235 239 311 313 312 314.0 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3QC9D P28327 31 533 561.0 ADP:700 ATPlike Active DFGin 6.9233 13.5167 BLAminus -151.29, 174.11 71.25, 99.27 -130.54, 20.81 276.77, 98.72 -58.99, -24.3 in-in in 8.9307 Saltbr-in 3.0905 HRD-in -63.44, -57.63 71.87, -0.43 in-in-in SNCiii in-in ActLoopNT-in 2.9269 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.95, 134.69 APE9-dihe-na 141.2, -168.54 APE8-dihe-in -103.28, 126.55 APE8-rot-in 303.76 APE67-dihe-inflip 102.49, -2.5 -51.29, 121.62 APE12-dist-in 10.3966 APE11-dist-in 11.0439 APE10-dist-in 5.5135 APE9-dist-in 3.693 T8C,N480C None None XRAY 2.7 0.194 0.229 D 543.0 486.0 0 28 28 0 [[187, 452]] 1.0 3qc9 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4.0 260.0 257.0 331 332 333 335 337 216 235 239 311 313 312 314.0 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
CK1 HRR25 Q6FS46_CANGA 4XH0A Q6FS46 3 397 495.0 ADP:501 ATPlike None DFGin 6.443 15.3833 BLAminus -128.64, -179.51 59.61, 77.98 -98.4, 10.06 283.06, 95.13 -55.51, -31.98 in-none in 8.1487 Saltbr-none 999.0 HRD-in -77.95, -46.78 69.84, 1.34 none-in-in SNCnii in-in ActLoopNT-in 2.7696 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.48, 125.7 APE9-dihe-na -118.27, -46.73 APE8-dihe-in -107.01, 112.94 APE8-rot-in 317.73 APE67-dihe-in -59.61, -42.11 -60.33, -32.21 APE12-dist-in 13.2808 APE11-dist-in 12.5221 APE10-dist-in 6.9261 APE9-dist-in 5.2004 K38R None None XRAY 1.99 0.168 0.2 A 403.0 350.0 5 35 35 0 [[9, 275]] 1.0 4xh0 Candida glabrata CK1_HRR25_CANGA CK1 2.6e-101 344.7 1.0 261.0 261.0 148 149 150 152 154 38 52 56 125 127 126 128.0 195 183 178 177 176 175 174 173 172 83 non-specific serine/threonine protein kinase
CK1 HRR25 Q6FS46_CANGA 4XHGA Q6FS46 2 397 495.0 ADP:501 ATPlike Inactive DFGin 6.7681 15.5237 BLAminus -126.45, -178.1 65.49, 74.25 -101.88, 16.36 285.39, 86.86 -58.89, -30.96 in-none in 8.2372 Saltbr-none 999.0 HRD-in -77.78, -51.52 75.28, -1.16 none-in-out SNCnio in-out ActLoopNT-in 2.8504 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -115.41, -44.98 APE9-dihe-na -99.02, -152.38 APE8-dihe-in -72.06, 134.26 APE8-rot-in 284.45 APE67-dihe-in -61.84, -37.14 -105.15, 28.83 APE12-dist-in 12.9854 APE11-dist-in 12.4375 APE10-dist-out 8.315 APE9-dist-out 8.1809 K38R None None XRAY 2.15 0.176 0.216 A 403.0 357.0 0 35 35 0 [[9, 275]] 1.0 4xhg Candida glabrata CK1_HRR25_CANGA CK1 2.6e-101 344.7 1.0 261.0 261.0 148 149 150 152 154 38 52 56 125 127 126 128.0 195 183 178 177 176 175 174 173 172 83 non-specific serine/threonine protein kinase
AGC PRKACA KAPCA_CRIGR 6EM6A P25321 12 351 351.0 ADP:60401 ATPlike Inactive DFGin 6.8591 14.8208 BLAminus -128.32, 163.45 74.87, 92.52 -104.27, 28.45 286.23, 74.8 -62.75, -23.58 in-out in 9.7038 Saltbr-out 4.3621 HRD-in -85.36, -55.87 71.35, 12.71 out-in-in SNCoii in-in ActLoopNT-in 2.9302 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.91, 157.75 APE9-dihe-na 127.42, -164.4 APE8-dihe-in -115.9, 133.37 APE8-rot-in 304.12 APE67-dihe-in -57.32, -23.54 -48.16, -51.44 APE12-dist-in 8.0456 APE11-dist-in 11.3093 APE10-dist-in 5.7368 APE9-dist-in 3.819 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.64 0.175 0.191 A 353.0 340.0 0 25 25 0 [[44, 298]] 1.0 6em6 Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6EM7A P25321 11 351 351.0 ADP:60403 ATPlike Active DFGin 5.924 14.3384 BLAminus -118.71, 173.1 68.53, 85.06 -96.18, 23.36 270.78, 55.34 -59.75, -28.55 in-in in 8.7405 Saltbr-in 2.7108 HRD-in -88.33, -53.93 74.88, 10.19 in-in-in SNCiii in-in ActLoopNT-in 2.9674 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.73, 159.92 APE9-dihe-na 127.98, -160.75 APE8-dihe-in -119.5, 137.47 APE8-rot-in 298.57 APE67-dihe-in -59.39, -22.73 -49.47, -50.59 APE12-dist-in 8.0499 APE11-dist-in 11.4294 APE10-dist-in 5.809 APE9-dist-in 3.6743 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.238 0.139 0.157 A 353.0 341.0 0 25 25 0 [[44, 298]] 1.0 6em7 Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CMGC CDK Q5CRJ8_CRYPI 3NIZA Q5CRJ8 1 293 295.0 ADP:60314 ATPlike Inactive DFGin 6.414 14.9205 BLAminus -148.14, 171.85 62.34, 76.33 -90.55, 26.42 283.17, 83.82 -64.08, -27.13 in-in in 9.1988 Saltbr-in 3.0509 HRD-in -69.04, -53.75 72.92, -5.13 in-in-out SNCiio in-out ActLoopNT-in 2.9042 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -75.55, 106.41 APE9-dihe-na -120.78, 159.03 APE8-dihe-in -63.65, 138.42 APE8-rot-out 189.36 APE67-dihe-in -64.68, -19.03 -103.04, 13.52 APE12-dist-in 10.7004 APE11-dist-in 9.7673 APE10-dist-out 13.8921 APE9-dist-out 9.5481 None None None XRAY 2.4 0.223 0.256 A 311.0 284.0 9 28 25 3 [[5, 286]] 1.0 3niz Cryptosporidium parvum CMGC_CDK_CRYPI CMGC 1.9e-86 296.3 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 2 homolog
CAMK PLK1 Q4KMI8_DANRE 3D5WA Q4KMI8 24 310 595.0 ADP:313 ATPlike Inactive DFGin 5.8398 15.103 BLAminus -136.31, -173.3 52.58, 90.43 -100.9, 29.72 290.61, 88.81 -67.31, -18.54 out-out out 10.538 Saltbr-out 4.5698 HRD-in -72.81, -47.33 67.56, -5.93 out-in-in SNCoii in-in ActLoopNT-in 2.9013 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.0, 153.74 APE9-dihe-na 145.11, -167.91 APE8-dihe-in -110.25, 127.19 APE8-rot-in 299.86 APE67-dihe-in -70.02, -15.96 -37.98, -47.89 APE12-dist-in 8.2509 APE11-dist-in 11.2747 APE10-dist-in 5.6458 APE9-dist-in 3.9124 None TPO196 TPO196 XRAY 2.6 0.244 0.271 A 317.0 285.0 2 28 28 0 [[39, 291]] 1.0 3d5w Danio rerio CAMK_PLK1_DANRE CAMK 4.6e-77 264.7 1.0 256.0 256.0 179 180 181 183 185 68 87 91 159 161 160 162.0 219 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase PLK
OTHER POMK SG196_DANRE 5GZAA Q5U3W1 53 342 347.0 ADP:401,ZZ1:405 ATPlike,Allosteric Pseudo DFGin 5.3569 13.1741 None -145.49, -53.43 -88.36, 87.6 -105.44, 34.02 303.67, 0.43 -66.19, -35.84 none-na none 999.0 Saltbr-na 999.0 HRD-out -76.02, 100.34 -84.46, -37.81 na-in-out SNCaio in-out ActLoopNT-in 3.1764 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iioo APE10-dihe-na -72.0, 131.22 APE9-dihe-na -98.58, 149.02 APE8-dihe-in -137.88, 170.05 APE8-rot-out 49.36 APE67-dihe-out -89.83, -15.07 100.95, 169.89 APE12-dist-in 12.1638 APE11-dist-in 13.9361 APE10-dist-out 17.3588 APE9-dist-out 9.4145 None None None XRAY 2.0 0.203 0.218 A 290.0 290.0 0 30 30 0 [[72, 335]] 1.0 5gza Danio rerio OTHER_POMK_DANRE POMK 3.3e-138 465.4 1.0 265.0 265.0 224 225 226 228 230 106 120 124 199 201 200 202.0 278 254 249 248 247 246 245 244 243 148 Protein O-mannose kinase
CAMK CAMKII KCC2A_DROME 5FG8A Q00168 7 275 530.0 ADP:301 ATPlike Active DFGin 5.8825 14.2303 BLAminus -120.35, -179.38 64.2, 77.37 -92.62, 22.59 287.14, 78.3 -59.18, -27.49 in-in in 8.9956 Saltbr-in 2.7976 HRD-in -79.26, -45.5 78.31, -3.25 in-in-in SNCiii in-in ActLoopNT-in 2.9362 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.29, 153.59 APE9-dihe-na 138.39, -158.82 APE8-dihe-in -123.15, 126.57 APE8-rot-in 291.32 APE67-dihe-in -61.12, -15.42 -38.96, -61.46 APE12-dist-in 10.2082 APE11-dist-in 11.8158 APE10-dist-in 6.2893 APE9-dist-in 3.4793 None None None XRAY 1.955 0.192 0.221 A 285.0 269.0 0 28 28 0 [[14, 272]] 1.0 5fg8 Drosophila melanogaster CAMK_CAMKII_DROME CAMK 6.3e-98 333.1 1.0 256.0 256.0 156 157 158 160 162 43 61 65 133 135 134 136.0 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II alpha chain
CAMK CAMKII KCC2A_DROME 5HU3A Q00168 7 272 530.0 ADP:301 ATPlike Active DFGin 5.6249 14.217 BLAminus -125.3, -175.54 57.54, 73.58 -90.7, 26.83 289.37, 84.29 -62.44, -29.23 in-in in 8.9517 Saltbr-in 2.6715 HRD-in -75.88, -45.31 74.57, -1.26 in-in-in SNCiii in-in ActLoopNT-in 2.9044 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.12, 157.18 APE9-dihe-na 139.99, -158.88 APE8-dihe-in -121.63, 130.83 APE8-rot-in 294.31 APE67-dihe-in -66.75, -12.95 -42.37, -59.45 APE12-dist-in 10.0585 APE11-dist-in 11.7662 APE10-dist-in 6.2771 APE9-dist-in 3.5644 D136N None None XRAY 1.885 0.194 0.228 A 285.0 266.0 0 28 28 0 [[14, 272]] 1.0 5hu3 Drosophila melanogaster CAMK_CAMKII_DROME CAMK 5.7e-97 329.9 1.0 256.0 256.0 156 157 158 160 162 43 61 65 133 135 134 136.0 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II alpha chain
CAMK OBSCN-1 OBSCN_DROME 8AK3A A8DYP0 3186 3477 4218.0 ADP:63501 ATPlike Pseudo DFGin 5.9051 13.4845 BLAminus -132.07, -172.8 60.67, 81.34 -101.92, 21.49 307.26, 110.13 -57.27, -33.59 in-in in 7.72 Saltbr-in 2.7612 HRD-in -74.37, -46.4 81.73, -14.06 in-in-in SNCiii in-in ActLoopNT-in 2.8971 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -140.07, 151.0 APE9-dihe-na 162.46, 172.55 APE8-dihe-in -86.0, 119.15 APE8-rot-na 203.36 APE67-dihe-in -78.57, -5.95 -56.15, -31.0 APE12-dist-in 8.0475 APE11-dist-in 10.0079 APE10-dist-in 6.6911 APE9-dist-in 5.7871 None None None XRAY 1.9 0.175 0.208 A 297.0 292.0 0 27 27 0 [[3186, 3440], [3897, 4151]] 2.0 8ak3 Drosophila melanogaster CAMK_OBSCN-1_DROME CAMK 2.3e-61 213.3 1.0 256.0 256.0 3325 3326 3327 3329 3331 3215 3230 3234 3303 3305 3304 3306.0 3364 3352 3347 3346 3345 3344 3343 3342 3341 3260 Protein Obscurin
OTHER BUBR1 A1Z6I7_DROME 6JKMA A1Z6I7 1127 1459 1460.0 ADP:61501 ATPlike Inactive DFGin 6.0094 13.9481 BLAminus -128.73, 177.45 65.82, 73.45 -92.38, 26.0 302.65, 107.99 -57.62, -35.04 in-in in 8.3334 Saltbr-in 2.9873 HRD-in -63.93, -46.09 73.48, 2.84 in-in-out SNCiio in-out ActLoopNT-in 2.7547 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooo APE10-dihe-na -54.34, 146.08 APE9-dihe-na -76.3, -56.25 APE8-dihe-in -62.83, 122.42 APE8-rot-na 191.74 APE67-dihe-in -57.79, -24.72 -57.87, -34.67 APE12-dist-in 12.1217 APE11-dist-out 15.9738 APE10-dist-out 12.4259 APE9-dist-out 12.3951 None None None XRAY 1.95 0.181 0.226 A 341.0 333.0 0 30 30 0 [[1175, 1438]] 1.0 6jkm Drosophila melanogaster OTHER_BUBR1_DROME BUB 7.6e-133 447.7 1.0 265.0 265.0 1325 1326 1327 1329 1331 1204 1213 1217 1298 1300 1299 1301.0 1367 1355 1350 1349 1348 1347 1346 1345 1344 1251 Bub1-related kinase
CAMK CDPK Q3HNM4_EIMTE 4YSJA Q3HNM4 26 499 505.0 ADP:60506 ATPlike Active DFGin 6.6513 14.0048 BLAminus -140.39, -165.72 52.75, 66.63 -84.34, 22.0 285.15, 82.54 -78.31, -16.63 in-in in 8.3189 Saltbr-in 3.4823 HRD-in -81.29, -53.0 84.02, -6.2 in-in-in SNCiii in-in ActLoopNT-in 2.8976 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.58, 142.92 APE9-dihe-na 138.88, -163.22 APE8-dihe-in -136.98, 140.82 APE8-rot-in 303.29 APE67-dihe-in -62.88, -33.46 -45.59, -53.66 APE12-dist-in 9.1442 APE11-dist-in 11.5637 APE10-dist-in 5.9896 APE9-dist-in 3.4927 None None None XRAY 2.7 0.249 0.292 A 491.0 459.0 10 27 27 0 [[46, 303]] 1.0 4ysj Eimeria tenella CAMK_CDPK_EIMTE CAMK 6.1e-90 307.2 1.0 256.0 256.0 189 190 191 193 195 75 94 98 166 168 167 169.0 227 216 211 210 209 208 207 206 205 124 non-specific serine/threonine protein kinase
CAMK CDPK Q3HNM4_EIMTE 4YSJB Q3HNM4 26 499 505.0 ADP:60506 ATPlike Active DFGin 6.5952 13.9931 BLAminus -140.54, -165.92 54.1, 65.38 -84.49, 22.28 285.29, 82.38 -78.18, -16.85 in-in in 8.3003 Saltbr-in 3.4937 HRD-in -81.3, -52.72 84.55, -6.86 in-in-in SNCiii in-in ActLoopNT-in 2.8688 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.46, 142.21 APE9-dihe-na 137.64, -162.65 APE8-dihe-in -138.56, 141.54 APE8-rot-in 303.24 APE67-dihe-in -62.83, -32.98 -44.74, -55.37 APE12-dist-in 8.9007 APE11-dist-in 11.534 APE10-dist-in 5.9792 APE9-dist-in 3.5054 None None None XRAY 2.7 0.249 0.292 B 491.0 462.0 10 27 27 0 [[46, 303]] 1.0 4ysj Eimeria tenella CAMK_CDPK_EIMTE CAMK 6.1e-90 307.2 1.0 256.0 256.0 189 190 191 193 195 75 94 98 166 168 167 169.0 227 216 211 210 209 208 207 206 205 124 non-specific serine/threonine protein kinase
AGC CDC42BPB MRCKB_HUMAN 4UAKA Q9Y5S2 2 417 1711.0 ADP:60501 ATPlike Active DFGin 6.5356 13.3888 BLAminus -126.67, 169.91 71.43, 81.15 -99.11, 14.11 300.02, 102.96 -73.12, -5.53 in-in in 8.6348 Saltbr-in 2.7478 HRD-in -78.82, -49.28 69.95, 4.01 in-in-in SNCiii in-in ActLoopNT-in 2.9773 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.28, 157.85 APE9-dihe-na 87.21, -164.86 APE8-dihe-in -127.15, 132.61 APE8-rot-in 302.21 APE67-dihe-in -64.23, -20.61 -57.86, -36.49 APE12-dist-in 10.5108 APE11-dist-in 11.1514 APE10-dist-in 6.3128 APE9-dist-in 3.5478 None None None XRAY 1.73 0.198 0.243 A 419.0 401.0 0 29 29 0 [[76, 342]] 1.0 4uak Homo sapiens AGC_CDC42BPB_HUMAN AGC 6.5e-96 326.4 1.0 260.0 260.0 217 218 219 221 223 105 124 128 197 199 198 200.0 263 246 241 240 239 238 237 236 235 154 Serine/threonine-protein kinase MRCK beta
AGC PRKCI KPCI_HUMAN 5LIHA P41743 248 588 596.0 ADP:60601 ATPlike Active DFGin 5.4026 11.8632 BLAminus -129.58, 178.7 63.64, 84.98 -106.19, 67.5 320.36, 105.86 -96.86, -30.05 in-in in 9.1779 Saltbr-in 3.0311 HRD-in -49.42, -59.61 61.3, 24.72 in-in-in SNCiii in-in ActLoopNT-in 3.1093 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.76, 169.43 APE9-dihe-na 122.35, -170.42 APE8-dihe-in -91.96, 136.55 APE8-rot-in 289.3 APE67-dihe-in -72.22, -23.04 -49.75, -40.52 APE12-dist-in 7.983 APE11-dist-in 10.9856 APE10-dist-in 5.4207 APE9-dist-in 3.5596 None TPO412,TPO564 TPO412,TPO564 XRAY 3.25 0.258 0.284 A 349.0 326.0 15 28 28 0 [[254, 522]] 1.0 5lih Homo sapiens AGC_PRKCI_HUMAN AGC 1.1e-95 325.5 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 5LIHB P41743 249 588 596.0 ADP:60601 ATPlike Active DFGin 5.3101 11.8759 BLAminus -129.18, 178.42 63.46, 84.62 -106.43, 67.35 320.63, 105.98 -96.29, -29.69 in-in in 8.7197 Saltbr-in 2.5445 HRD-in -49.62, -59.64 61.27, 24.64 in-in-in SNCiii in-in ActLoopNT-in 3.1408 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.47, 168.99 APE9-dihe-na 122.16, -170.23 APE8-dihe-in -91.66, 136.86 APE8-rot-in 289.24 APE67-dihe-in -72.3, -22.91 -49.4, -40.32 APE12-dist-in 8.3287 APE11-dist-in 11.2559 APE10-dist-in 5.6928 APE9-dist-in 3.7423 None TPO412,TPO564 TPO412,TPO564 XRAY 3.25 0.258 0.284 B 349.0 320.0 20 28 28 0 [[254, 522]] 1.0 5lih Homo sapiens AGC_PRKCI_HUMAN AGC 1.1e-95 325.5 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 9EJMB P41743 249 588 596.0 ADP:60601 ATPlike None DFGin 6.2004 12.8648 BLAminus -142.99, -166.55 58.77, 70.37 -95.2, 28.65 312.71, 127.0 -80.74, 2.56 in-none in 9.1664 Saltbr-none 999.0 HRD-in -62.9, -53.16 64.41, -0.47 none-in-in SNCnii in-in ActLoopNT-in 3.1518 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.58, 153.63 APE9-dihe-na 128.65, 169.74 APE8-dihe-in -69.25, 127.47 APE8-rot-in 310.74 APE67-dihe-in -76.65, -32.17 -60.48, -21.91 APE12-dist-in 9.6026 APE11-dist-in 12.2532 APE10-dist-in 6.5946 APE9-dist-in 3.9282 None TPO412,TPO564 TPO412,TPO564 EM 3.33 999.0 999.0 B 596.0 322.0 9 28 28 0 [[254, 522]] 1.0 9ejm Homo sapiens AGC_PRKCI_HUMAN AGC 5.2e-95 323.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
CAMK AURKA AURKA_HUMAN 8GUWA O14965 506 388 403.0 ADP:60501 ATPlike Inactive DFGin 5.4961 16.0011 ABAminus -116.4, -50.49 -101.78, 116.28 -108.31, 28.43 281.67, 88.04 -72.88, -24.68 out-out out 11.7793 Saltbr-out 6.9626 HRD-out -52.32, 144.81 -137.03, 32.44 out-in-out SNCoio in-out ActLoopNT-in 2.989 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 154.24 APE8-dihe-in -135.99, 160.18 APE8-rot-out 182.57 APE67-dihe-in -45.22, -30.26 -102.15, -5.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 22.8351 C290A,C393A None None XRAY 2.7 0.216 0.258 A 304.0 259.0 7 26 19 7 [[133, 383]] 1.0 8guw Homo sapiens CAMK_AURKA_HUMAN CAMK 1.2e-78 270.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8GUWB O14965 507 390 403.0 ADP:60501 ATPlike Inactive DFGin 5.2903 15.6844 ABAminus -103.46, -56.86 -84.59, 164.71 -149.11, 43.73 280.55, 102.4 -37.77, -51.78 out-out out 11.2219 Saltbr-out 10.1241 HRD-out -88.2, 114.65 -57.32, -35.01 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 120.59 APE8-rot-out 188.97 APE67-dihe-out 79.95, -4.59 -68.08, -173.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C290A,C393A None None XRAY 2.7 0.216 0.258 B 304.0 250.0 13 26 13 13 [[133, 383]] 1.0 8guw Homo sapiens CAMK_AURKA_HUMAN CAMK 1.2e-78 270.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8GUWC O14965 506 388 403.0 ADP:60501 ATPlike Inactive DFGin 5.7941 16.123 ABAminus -112.39, -57.42 -66.39, 155.71 -143.31, 23.7 266.43, 102.44 -50.18, -24.58 out-out out 11.5307 Saltbr-out 6.1466 HRD-out -98.37, 113.81 -121.54, 28.92 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -46.16 APE8-rot-in 299.01 APE67-dihe-in -63.17, -8.64 -58.96, -54.21 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C290A,C393A None None XRAY 2.7 0.216 0.258 C 304.0 248.0 18 26 12 14 [[133, 383]] 1.0 8guw Homo sapiens CAMK_AURKA_HUMAN CAMK 1.2e-78 270.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4BN1A O14965 126 388 403.0 ADP:1391 ATPlike Inactive DFGin 5.7586 14.9619 BLAminus -135.76, 176.64 57.4, 85.44 -97.06, 20.67 283.26, 70.95 -48.27, -40.43 in-in in 9.2277 Saltbr-in 2.7169 HRD-in -70.78, -55.66 70.88, -1.02 in-in-out SNCiio in-out ActLoopNT-in 2.8 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na 16.45, -154.0 APE9-dihe-na 66.92, -173.53 APE8-dihe-in -66.46, 155.86 APE8-rot-out 182.79 APE67-dihe-in -44.49, -32.18 -93.83, -6.12 APE12-dist-in 12.1139 APE11-dist-in 8.7308 APE10-dist-out 13.7066 APE9-dist-out 11.1591 V174M TPO287,TPO288 TPO287,TPO288 XRAY 2.499 0.195 0.244 A 285.0 263.0 0 26 26 0 [[133, 383]] 1.0 4bn1 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.5e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 1MQ4A O14965 126 388 403.0 ADP:2001 ATPlike Inactive DFGin 5.607 15.2135 BLAminus -132.59, 179.34 62.49, 72.25 -91.07, 21.51 279.91, 70.01 -61.32, -27.71 in-in in 9.0551 Saltbr-in 2.8803 HRD-in -82.66, -49.31 72.48, -1.39 in-in-out SNCiio in-out ActLoopNT-in 2.9232 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -97.21, -164.83 APE9-dihe-na -146.02, -127.82 APE8-dihe-in -61.49, 131.42 APE8-rot-out 178.11 APE67-dihe-in -51.42, -34.84 -86.66, -6.25 APE12-dist-in 7.6815 APE11-dist-in 11.8468 APE10-dist-out 10.5866 APE9-dist-out 9.9776 None None None XRAY 1.9 0.229 0.273 A 272.0 261.0 2 26 24 2 [[133, 383]] 1.0 1mq4 Homo sapiens CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 1OL5A O14965 123 388 403.0 ADP:1388 ATPlike Active DFGin 5.5782 15.0961 BLAminus -139.2, -172.08 52.22, 80.16 -90.83, 24.66 282.61, 72.55 -49.87, -44.18 in-in in 9.4508 Saltbr-in 2.9117 HRD-in -63.28, -60.88 73.6, 1.59 in-in-in SNCiii in-in ActLoopNT-in 2.9276 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.42, 162.5 APE9-dihe-na 119.45, -153.19 APE8-dihe-in -110.77, 140.24 APE8-rot-in 313.06 APE67-dihe-in -62.23, -14.3 -43.16, -62.5 APE12-dist-in 8.1744 APE11-dist-in 10.9573 APE10-dist-in 5.2741 APE9-dist-in 3.683 None TPO287,TPO288 TPO287,TPO288 XRAY 2.5 0.194 0.252 A 282.0 266.0 0 26 26 0 [[133, 383]] 1.0 1ol5 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 1OL7A O14965 127 390 403.0 ADP:531 ATPlike Inactive DFGin 5.4287 15.0428 BLAminus -133.12, -167.56 48.98, 74.14 -88.94, 32.44 285.93, 64.91 -57.61, -36.14 in-in in 9.5058 Saltbr-in 3.0551 HRD-in -75.56, -48.34 63.05, 5.8 in-in-out SNCiio in-out ActLoopNT-in 2.9785 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -104.11, 138.56 APE9-dihe-na 156.93, 143.05 APE8-dihe-in -89.37, 102.83 APE8-rot-out 182.11 APE67-dihe-in -15.17, -56.94 -45.24, -37.82 APE12-dist-in 11.2666 APE11-dist-in 11.2056 APE10-dist-out 10.4649 APE9-dist-out 8.2689 None TPO287,TPO288 TPO287,TPO288 XRAY 2.75 0.257 0.296 A 282.0 264.0 0 26 26 0 [[133, 383]] 1.0 1ol7 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4DEEA O14965 124 394 403.0 ADP:503 ATPlike Inactive DFGin 5.9771 15.579 BLAminus -131.54, -177.86 61.33, 72.14 -88.35, 17.45 278.56, 69.2 -56.76, -24.29 in-in in 9.2363 Saltbr-in 2.8355 HRD-in -80.53, -51.88 66.61, 1.43 in-in-out SNCiio in-out ActLoopNT-in 2.6858 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -125.87, -53.37 APE9-dihe-na -86.66, -134.63 APE8-dihe-in -80.8, 152.73 APE8-rot-out 187.03 APE67-dihe-in -37.34, -40.8 -92.92, -9.81 APE12-dist-in 12.1076 APE11-dist-in 10.7866 APE10-dist-out 10.7625 APE9-dist-out 10.5323 T287D None None XRAY 2.3 0.213 0.259 A 279.0 271.0 0 26 26 0 [[133, 383]] 1.0 4dee Homo sapiens CAMK_AURKA_HUMAN CAMK 8.7e-80 273.7 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5LXMA O14965 126 392 403.0 ADP:60501 ATPlike Active DFGin 5.3906 14.9756 BLAminus -135.45, -179.78 54.7, 80.97 -90.8, 30.12 283.16, 71.51 -72.4, -3.16 in-in in 9.2473 Saltbr-in 2.7237 HRD-in -74.23, -48.55 66.99, 5.01 in-in-in SNCiii in-in ActLoopNT-in 3.1136 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.91, 137.37 APE9-dihe-na 128.62, -150.21 APE8-dihe-in -129.87, 142.81 APE8-rot-in 303.47 APE67-dihe-in -69.71, -10.62 -37.99, -61.07 APE12-dist-in 8.2574 APE11-dist-in 10.6918 APE10-dist-in 5.2126 APE9-dist-in 3.2978 C290A,C393A TPO288 TPO288 XRAY 2.08 0.202 0.243 A 283.0 267.0 0 26 26 0 [[133, 383]] 1.0 5lxm Homo sapiens CAMK_AURKA_HUMAN CAMK 9.2e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4CEGA O14965 127 391 403.0 ADP:1392 ATPlike Inactive DFGin 6.3211 15.6655 BLAminus -126.79, -176.42 60.85, 65.85 -88.73, 20.26 276.07, 70.68 -62.71, -30.16 in-in in 8.907 Saltbr-in 2.7521 HRD-in -80.9, -50.34 70.05, 0.74 in-in-out SNCiio in-out ActLoopNT-in 2.8816 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -88.79, -42.25 APE9-dihe-na -103.79, -144.9 APE8-dihe-in -67.83, 148.92 APE8-rot-out 184.96 APE67-dihe-in -49.78, -34.34 -90.88, -2.74 APE12-dist-in 12.0347 APE11-dist-in 10.9906 APE10-dist-out 11.5002 APE9-dist-out 10.933 C290A,C393A TPO288 TPO288 XRAY 2.1 0.202 0.237 A 285.0 265.0 0 26 26 0 [[133, 383]] 1.0 4ceg Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5G1XA O14965 126 389 403.0 ADP:1390 ATPlike Active DFGin 5.3433 15.03 BLAminus -132.86, -170.57 52.68, 76.5 -90.96, 13.96 279.12, 78.43 -59.51, -20.51 in-in in 9.2783 Saltbr-in 2.828 HRD-in -82.61, -50.12 70.7, 5.33 in-in-in SNCiii in-in ActLoopNT-in 2.9632 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.42, -179.26 APE9-dihe-na 65.74, -155.89 APE8-dihe-in -128.23, 121.78 APE8-rot-in 304.75 APE67-dihe-in -61.27, -19.7 -46.07, -47.67 APE12-dist-in 8.2472 APE11-dist-in 10.7994 APE10-dist-in 5.5303 APE9-dist-in 3.699 C290A,C393A TPO288 TPO288 XRAY 1.72 0.177 0.195 A 285.0 264.0 0 26 26 0 [[133, 383]] 1.0 5g1x Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORLA O14965 127 391 403.0 ADP:401,A4W:407 ATPlike,Allosteric Inactive DFGin 7.0659 16.6489 BLAminus -127.84, -172.28 56.81, 60.19 -82.35, 15.9 271.2, 75.61 -63.85, -28.67 in-in in 9.0488 Saltbr-in 2.7502 HRD-in -78.27, -48.5 74.34, -1.48 in-in-out SNCiio in-out ActLoopNT-in 2.9772 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -99.11, -104.69 APE9-dihe-na -74.24, -110.44 APE8-dihe-in -76.15, 148.12 APE8-rot-out 189.45 APE67-dihe-in -56.74, -24.81 -85.95, -8.4 APE12-dist-in 12.0723 APE11-dist-in 10.971 APE10-dist-out 10.3882 APE9-dist-out 11.2888 C290A TPO288 TPO288 XRAY 1.69 0.206 0.238 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orl Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORNA O14965 127 391 403.0 ADP:401,A5E:404 ATPlike,Allosteric Inactive DFGin 5.6718 15.4032 BLAminus -130.34, -174.38 54.92, 79.97 -94.37, 17.54 279.26, 75.58 -55.07, -30.09 in-in in 9.3539 Saltbr-in 2.9285 HRD-in -81.32, -50.86 72.88, 0.4 in-in-out SNCiio in-out ActLoopNT-in 3.025 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -63.8, -59.63 APE9-dihe-na -97.49, -117.04 APE8-dihe-in -91.34, 143.03 APE8-rot-out 191.17 APE67-dihe-in -51.25, -26.05 -82.57, -15.54 APE12-dist-in 12.3855 APE11-dist-in 10.4017 APE10-dist-out 11.4938 APE9-dist-out 11.3568 None TPO288 TPO288 XRAY 2.19 0.203 0.262 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orn Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OROA O14965 127 391 403.0 ADP:401,A5H:404 ATPlike,Allosteric Inactive DFGin 5.6776 15.3373 BLAminus -140.88, -178.26 60.46, 77.77 -94.07, 18.69 277.24, 76.82 -52.63, -39.97 in-in in 9.2726 Saltbr-in 3.0567 HRD-in -74.27, -52.41 74.24, -3.23 in-in-out SNCiio in-out ActLoopNT-in 2.8427 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -87.43, -63.56 APE9-dihe-na -103.72, -111.07 APE8-dihe-in -78.78, 141.92 APE8-rot-out 181.93 APE67-dihe-in -53.21, -24.39 -89.75, -10.63 APE12-dist-in 12.176 APE11-dist-in 10.5588 APE10-dist-out 11.0011 APE9-dist-out 11.5009 None TPO288 TPO288 XRAY 2.12 0.223 0.281 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5oro Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORPA O14965 127 391 403.0 ADP:401,A5K:404 ATPlike,Allosteric Inactive DFGin 5.8123 15.4919 BLAminus -139.84, -179.78 59.55, 79.52 -94.35, 18.72 278.85, 73.24 -45.22, -42.84 in-in in 9.3871 Saltbr-in 2.908 HRD-in -83.1, -49.94 72.65, -1.94 in-in-out SNCiio in-out ActLoopNT-in 3.0344 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -75.76, -64.68 APE9-dihe-na -107.0, -110.58 APE8-dihe-in -81.78, 136.28 APE8-rot-out 180.06 APE67-dihe-in -57.19, -28.31 -85.06, -6.26 APE12-dist-in 12.3511 APE11-dist-in 10.944 APE10-dist-out 10.7661 APE9-dist-out 11.3666 None TPO288 TPO288 XRAY 2.19 0.21 0.273 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orp Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORRA O14965 127 391 403.0 ADP:401,A5Q:404 ATPlike,Allosteric Inactive DFGin 5.6648 15.4968 BLAminus -133.78, -179.48 60.85, 73.72 -91.04, 29.58 281.03, 75.21 -67.99, -25.16 in-in in 9.4213 Saltbr-in 3.055 HRD-in -80.95, -50.87 71.36, -2.01 in-in-out SNCiio in-out ActLoopNT-in 3.0207 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -79.12, -78.89 APE9-dihe-na -94.43, -116.97 APE8-dihe-in -78.43, 147.39 APE8-rot-out 182.93 APE67-dihe-in -56.59, -23.94 -94.11, -3.91 APE12-dist-in 12.2613 APE11-dist-in 11.0201 APE10-dist-out 10.4273 APE9-dist-out 11.0664 None TPO288 TPO288 XRAY 2.09 0.202 0.256 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orr Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORSA O14965 127 391 403.0 ADP:401,A5W:404 ATPlike,Allosteric Inactive DFGin 5.9555 15.6826 BLAminus -133.47, -175.79 56.95, 73.99 -92.77, 17.89 276.34, 75.78 -60.0, -24.97 in-in in 9.1746 Saltbr-in 2.899 HRD-in -79.83, -50.16 70.98, -0.5 in-in-out SNCiio in-out ActLoopNT-in 3.0015 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -90.64, -79.2 APE9-dihe-na -92.74, -115.85 APE8-dihe-in -81.19, 144.15 APE8-rot-out 184.83 APE67-dihe-in -58.67, -28.41 -85.39, -4.34 APE12-dist-in 12.1926 APE11-dist-in 10.9556 APE10-dist-out 10.6259 APE9-dist-out 11.291 None TPO288 TPO288 XRAY 1.98 0.209 0.257 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5ors Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORTA O14965 127 391 403.0 ADP:401,A5Z:406 ATPlike,Allosteric Inactive DFGin 5.9989 15.7538 BLAminus -125.96, -170.73 54.43, 75.09 -90.85, 19.73 277.07, 68.86 -49.78, -34.73 in-in in 9.1957 Saltbr-in 3.0255 HRD-in -79.74, -50.38 68.95, 1.55 in-in-out SNCiio in-out ActLoopNT-in 3.0837 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -85.06, -64.36 APE9-dihe-na -96.27, -115.21 APE8-dihe-in -89.65, 146.92 APE8-rot-out 194.22 APE67-dihe-in -52.62, -22.53 -93.73, -12.57 APE12-dist-in 12.5307 APE11-dist-in 10.9187 APE10-dist-out 10.824 APE9-dist-out 11.0185 None TPO288 TPO288 XRAY 2.56 0.208 0.275 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5ort Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORVA O14965 127 391 403.0 ADP:401,A65:406 ATPlike,Allosteric Inactive DFGin 5.6645 15.44 BLAminus -136.16, -176.05 58.92, 71.82 -89.03, 22.25 278.38, 76.78 -63.69, -25.31 in-in in 9.2454 Saltbr-in 2.8863 HRD-in -82.57, -52.35 73.38, 1.05 in-in-out SNCiio in-out ActLoopNT-in 3.0056 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -75.39, -87.03 APE9-dihe-na -89.16, -112.46 APE8-dihe-in -77.62, 139.73 APE8-rot-out 181.74 APE67-dihe-in -57.59, -25.24 -84.67, -4.17 APE12-dist-in 12.3135 APE11-dist-in 10.8773 APE10-dist-out 10.4209 APE9-dist-out 11.2549 None TPO288 TPO288 XRAY 1.88 0.214 0.268 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orv Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORWA O14965 127 391 403.0 ADP:401,A6E:404 ATPlike,Allosteric Inactive DFGin 5.7064 15.413 BLAminus -131.01, -175.69 56.41, 78.46 -94.05, 21.38 277.67, 78.36 -59.98, -27.55 in-in in 9.316 Saltbr-in 3.0048 HRD-in -84.25, -51.01 70.55, 2.29 in-in-out SNCiio in-out ActLoopNT-in 3.0694 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -84.32, -59.08 APE9-dihe-na -102.85, -110.93 APE8-dihe-in -86.24, 134.05 APE8-rot-out 178.0 APE67-dihe-in -62.04, -25.17 -80.18, -4.89 APE12-dist-in 12.2689 APE11-dist-in 10.8105 APE10-dist-out 10.9798 APE9-dist-out 11.1995 None TPO288 TPO288 XRAY 2.0 0.217 0.27 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orw Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORXA O14965 127 391 403.0 ADP:401,A6H:404 ATPlike,Allosteric Inactive DFGin 5.4831 15.3325 BLAminus -135.37, -175.69 58.5, 74.51 -88.48, 21.31 281.01, 74.45 -55.7, -31.23 in-in in 9.3916 Saltbr-in 2.8871 HRD-in -84.87, -52.92 73.65, 2.44 in-in-out SNCiio in-out ActLoopNT-in 2.9566 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -81.41, -75.31 APE9-dihe-na -97.77, -112.93 APE8-dihe-in -77.56, 136.59 APE8-rot-out 185.81 APE67-dihe-in -60.3, -23.27 -81.45, -7.22 APE12-dist-in 12.2711 APE11-dist-in 10.9764 APE10-dist-out 10.2482 APE9-dist-out 10.9212 None TPO288 TPO288 XRAY 1.88 0.222 0.27 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orx Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORYA O14965 127 391 403.0 ADP:401,AY4:406 ATPlike,Allosteric Inactive DFGin 5.665 15.4321 BLAminus -133.35, -178.83 58.64, 81.27 -98.02, 26.99 280.05, 73.77 -66.34, -26.48 in-in in 9.4129 Saltbr-in 3.0153 HRD-in -83.1, -49.94 67.85, 0.8 in-in-out SNCiio in-out ActLoopNT-in 2.9683 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -85.35, -78.87 APE9-dihe-na -90.27, -119.1 APE8-dihe-in -76.79, 146.69 APE8-rot-out 180.58 APE67-dihe-in -53.43, -25.94 -95.91, -5.0 APE12-dist-in 12.4465 APE11-dist-in 11.0475 APE10-dist-out 10.7427 APE9-dist-out 11.1533 None TPO288 TPO288 XRAY 1.99 0.207 0.265 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5ory Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ORZA O14965 127 391 403.0 ADP:401,A6W:407 ATPlike,Allosteric Inactive DFGin 5.6745 15.4067 BLAminus -135.57, -175.22 57.46, 80.66 -98.54, 24.2 276.77, 79.7 -65.5, -21.43 in-in in 9.2536 Saltbr-in 3.1111 HRD-in -80.39, -48.42 71.09, -2.39 in-in-out SNCiio in-out ActLoopNT-in 3.0623 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -82.59, -77.55 APE9-dihe-na -100.89, -113.21 APE8-dihe-in -76.47, 144.8 APE8-rot-out 177.65 APE67-dihe-in -57.19, -24.65 -94.21, -4.24 APE12-dist-in 12.3009 APE11-dist-in 10.8877 APE10-dist-out 10.4018 APE9-dist-out 11.2099 None TPO288 TPO288 XRAY 1.92 0.199 0.244 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5orz Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS0A O14965 127 391 403.0 ADP:401,A6Z:404 ATPlike,Allosteric Inactive DFGin 5.6629 15.4407 BLAminus -133.76, -174.78 57.78, 75.99 -91.75, 21.09 277.99, 75.39 -60.35, -28.95 in-in in 9.311 Saltbr-in 2.7878 HRD-in -86.51, -49.56 71.53, 0.91 in-in-out SNCiio in-out ActLoopNT-in 2.9596 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -90.57, -76.63 APE9-dihe-na -103.27, -112.09 APE8-dihe-in -75.93, 143.74 APE8-rot-out 179.33 APE67-dihe-in -59.48, -25.37 -86.69, -3.69 APE12-dist-in 12.1557 APE11-dist-in 10.864 APE10-dist-out 10.2569 APE9-dist-out 11.2043 None TPO288 TPO288 XRAY 1.74 0.22 0.264 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5os0 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS1A O14965 127 391 403.0 ADP:401,A7H:407 ATPlike,Allosteric Inactive DFGin 5.601 15.3207 BLAminus -135.04, -179.66 61.87, 77.96 -95.19, 22.65 277.87, 73.62 -63.45, -26.73 in-in in 9.2237 Saltbr-in 2.9199 HRD-in -84.64, -47.57 66.67, 4.82 in-in-out SNCiio in-out ActLoopNT-in 3.0164 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -71.95, -77.41 APE9-dihe-na -100.69, -116.41 APE8-dihe-in -72.42, 138.52 APE8-rot-out 177.77 APE67-dihe-in -60.13, -26.29 -83.6, -2.57 APE12-dist-in 12.2392 APE11-dist-in 10.8166 APE10-dist-out 10.5993 APE9-dist-out 11.2579 None TPO288 TPO288 XRAY 1.9 0.203 0.25 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5os1 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS2A O14965 127 391 403.0 ADP:401,A7K:404 ATPlike,Allosteric Inactive DFGin 5.6983 15.5293 BLAminus -131.21, -175.25 58.7, 76.84 -90.56, 21.45 276.93, 76.69 -62.35, -9.35 in-in in 9.3094 Saltbr-in 2.9759 HRD-in -79.13, -51.53 72.78, 2.45 in-in-out SNCiio in-out ActLoopNT-in 3.0182 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -27.53 APE9-dihe-na -109.52, -133.64 APE8-dihe-in -78.79, 129.87 APE8-rot-out 174.59 APE67-dihe-in -60.88, -25.02 -78.66, -3.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.8302 APE9-dist-out 10.9565 None None None XRAY 1.92 0.213 0.251 A 265.0 261.0 4 26 22 4 [[133, 383]] 1.0 5os2 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS3A O14965 127 391 403.0 ADP:401,A7N:404 ATPlike,Allosteric Inactive DFGin 5.8534 15.6154 BLAminus -132.65, -178.67 63.71, 72.3 -91.21, 21.81 276.12, 75.45 -58.53, -29.86 in-in in 9.1686 Saltbr-in 2.9283 HRD-in -82.57, -48.69 69.82, -0.73 in-in-out SNCiio in-out ActLoopNT-in 2.9663 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -97.05, -71.52 APE9-dihe-na -103.15, -115.69 APE8-dihe-in -76.83, 145.54 APE8-rot-out 186.8 APE67-dihe-in -55.71, -28.81 -87.14, -3.16 APE12-dist-in 12.1833 APE11-dist-in 10.9495 APE10-dist-out 10.3755 APE9-dist-out 11.239 None TPO288 TPO288 XRAY 1.81 0.203 0.238 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5os3 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS4A O14965 127 391 403.0 ADP:401,A8H:404 ATPlike,Allosteric Inactive DFGin 5.5617 15.3883 BLAminus -130.51, -177.66 61.48, 75.55 -91.39, 22.5 279.03, 76.09 -60.73, -28.57 in-in in 9.2451 Saltbr-in 2.8621 HRD-in -82.71, -48.02 68.35, 3.92 in-in-out SNCiio in-out ActLoopNT-in 2.9591 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -77.92, -67.81 APE9-dihe-na -96.69, -121.48 APE8-dihe-in -75.57, 137.34 APE8-rot-out 180.49 APE67-dihe-in -57.86, -25.07 -81.82, -5.88 APE12-dist-in 12.2565 APE11-dist-in 10.8031 APE10-dist-out 10.9355 APE9-dist-out 11.2587 None TPO288 TPO288 XRAY 1.88 0.205 0.24 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5os4 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS6A O14965 127 391 403.0 ADP:401,A7Q:404 ATPlike,Allosteric Inactive DFGin 6.0291 15.7815 BLAminus -126.13, -169.53 51.73, 76.81 -92.36, 19.58 272.42, 79.82 -57.78, -34.45 in-in in 9.2445 Saltbr-in 2.995 HRD-in -81.41, -52.88 69.05, 4.37 in-in-out SNCiio in-out ActLoopNT-in 3.0404 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -77.03, -70.53 APE9-dihe-na -90.32, -115.88 APE8-dihe-in -84.85, 141.6 APE8-rot-out 180.13 APE67-dihe-in -64.32, -26.41 -86.27, 0.74 APE12-dist-in 12.2131 APE11-dist-in 10.8263 APE10-dist-out 10.7401 APE9-dist-out 10.9916 None TPO288 TPO288 XRAY 2.2 0.216 0.277 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5os6 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OSEA O14965 127 391 403.0 ADP:401,A98:404 ATPlike,Allosteric Inactive DFGin 5.6464 15.4407 BLAminus -134.11, -176.47 59.39, 78.15 -96.43, 21.72 274.12, 77.75 -65.33, -24.45 in-in in 9.1368 Saltbr-in 2.8845 HRD-in -78.93, -49.87 70.59, 0.35 in-in-out SNCiio in-out ActLoopNT-in 2.9592 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -81.25, -72.54 APE9-dihe-na -105.09, -114.94 APE8-dihe-in -73.18, 141.65 APE8-rot-out 184.53 APE67-dihe-in -56.53, -26.26 -88.57, -5.48 APE12-dist-in 12.1504 APE11-dist-in 10.9758 APE10-dist-out 10.508 APE9-dist-out 11.2527 None TPO288 TPO288 XRAY 1.9 0.192 0.237 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5ose Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OSFA O14965 127 391 403.0 ADP:401,A9E:404 ATPlike,Allosteric Inactive DFGin 5.7593 15.6562 BLAminus -131.88, -178.74 65.35, 71.33 -84.84, 21.28 278.92, 73.36 -65.0, -27.04 in-in in 9.3139 Saltbr-in 2.8266 HRD-in -85.08, -46.49 62.7, 8.17 in-in-out SNCiio in-out ActLoopNT-in 2.9651 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -87.68, -61.8 APE9-dihe-na -106.59, -110.06 APE8-dihe-in -85.81, 135.3 APE8-rot-out 180.39 APE67-dihe-in -56.65, -25.75 -79.56, -7.54 APE12-dist-in 12.2037 APE11-dist-in 10.6895 APE10-dist-out 10.9134 APE9-dist-out 11.4534 None TPO288 TPO288 XRAY 1.89 0.204 0.254 A 265.0 265.0 0 26 26 0 [[133, 383]] 1.0 5osf Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OSDA O14965 125 391 403.0 ADP:401,A9B:404 ATPlike,Allosteric Inactive DFGin 5.672 15.4437 BLAminus -133.73, -178.01 59.76, 77.67 -95.6, 25.32 277.59, 73.38 -66.16, -23.93 in-in in 9.1535 Saltbr-in 2.9136 HRD-in -79.03, -50.3 71.01, -1.56 in-in-out SNCiio in-out ActLoopNT-in 3.0371 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -81.55, -62.64 APE9-dihe-na -107.55, -120.42 APE8-dihe-in -75.26, 143.45 APE8-rot-out 177.88 APE67-dihe-in -54.13, -27.04 -91.57, -4.8 APE12-dist-in 12.2502 APE11-dist-in 11.0743 APE10-dist-out 10.8059 APE9-dist-out 11.1972 None TPO288 TPO288 XRAY 1.99 0.198 0.239 A 267.0 267.0 0 26 26 0 [[133, 383]] 1.0 5osd Homo sapiens CAMK_AURKA_HUMAN CAMK 7.4e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OS5A O14965 125 392 403.0 ADP:401,A8K:404 ATPlike,Allosteric Inactive DFGin 5.536 15.2749 BLAminus -135.35, -174.05 58.1, 79.63 -93.47, 22.72 276.13, 73.04 -64.31, -25.3 in-in in 9.3797 Saltbr-in 2.8681 HRD-in -80.2, -52.69 73.71, 2.64 in-in-out SNCiio in-out ActLoopNT-in 2.8801 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -96.33, -47.43 APE9-dihe-na -104.6, -130.88 APE8-dihe-in -73.88, 139.12 APE8-rot-out 187.09 APE67-dihe-in -61.32, -25.92 -83.14, -4.09 APE12-dist-in 12.2806 APE11-dist-in 10.8451 APE10-dist-out 11.3572 APE9-dist-out 10.9535 None TPO288 TPO288 XRAY 1.74 0.199 0.236 A 268.0 268.0 0 26 26 0 [[133, 383]] 1.0 5os5 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.5e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6R49A O14965 127 391 403.0 ADP:501,JSB:504 ATPlike,Allosteric Inactive DFGin 5.6142 15.4571 BLAminus -138.43, -175.42 57.6, 78.22 -94.44, 21.89 276.25, 76.24 -57.77, -33.65 in-in in 9.3806 Saltbr-in 2.8938 HRD-in -87.16, -51.58 76.44, -3.34 in-in-out SNCiio in-out ActLoopNT-in 3.1015 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -122.85 APE8-dihe-in -81.14, 140.15 APE8-rot-out 187.07 APE67-dihe-in -51.76, -30.76 -84.84, -7.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.0529 C290A,C393A TPO288 TPO288 XRAY 2.209 0.194 0.24 A 285.0 260.0 5 26 21 5 [[133, 383]] 1.0 6r49 Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6R4AA O14965 127 391 403.0 ADP:501,JRT:510 ATPlike,Allosteric Inactive DFGin 6.1565 15.9493 BLAminus -128.43, -176.18 59.16, 64.31 -84.29, 19.22 274.78, 74.05 -63.59, -28.66 in-in in 9.1016 Saltbr-in 2.8252 HRD-in -85.32, -47.41 69.85, -3.89 in-in-out SNCiio in-out ActLoopNT-in 3.0232 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -103.23, -102.89 APE9-dihe-na -87.4, -108.97 APE8-dihe-in -74.29, 145.29 APE8-rot-out 184.87 APE67-dihe-in -57.97, -25.59 -89.08, -1.69 APE12-dist-in 12.109 APE11-dist-in 10.8679 APE10-dist-out 9.9425 APE9-dist-out 11.4483 C290A,C393A TPO288 TPO288 XRAY 1.937 0.193 0.234 A 285.0 265.0 0 26 26 0 [[133, 383]] 1.0 6r4a Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6R4BA O14965 127 391 403.0 ADP:501,JSN:508 ATPlike,Allosteric Inactive DFGin 5.8943 15.6634 BLAminus -137.57, -177.62 60.57, 72.93 -89.1, 20.04 274.87, 75.15 -57.71, -33.47 in-in in 9.285 Saltbr-in 2.8908 HRD-in -83.52, -48.93 71.64, -3.16 in-in-out SNCiio in-out ActLoopNT-in 2.9599 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -86.33, -81.37 APE9-dihe-na -105.19, -110.27 APE8-dihe-in -73.56, 134.57 APE8-rot-out 182.29 APE67-dihe-in -52.75, -29.28 -80.52, -6.55 APE12-dist-in 12.1859 APE11-dist-in 10.9551 APE10-dist-out 10.1562 APE9-dist-out 11.3762 None TPO288 TPO288 XRAY 2.15 0.191 0.23 A 285.0 265.0 0 26 26 0 [[133, 383]] 1.0 6r4b Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6R4CA O14965 127 391 403.0 ADP:501,JRQ:507 ATPlike,Allosteric Inactive DFGin 6.0205 15.666 BLAminus -134.91, -179.34 60.98, 67.5 -85.83, 17.59 275.41, 71.94 -60.31, -30.9 in-in in 9.0676 Saltbr-in 2.7695 HRD-in -80.73, -51.78 76.01, -7.95 in-in-out SNCiio in-out ActLoopNT-in 2.8911 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -93.37, -96.1 APE9-dihe-na -98.19, -111.55 APE8-dihe-in -67.65, 142.09 APE8-rot-out 185.03 APE67-dihe-in -56.49, -28.95 -89.55, -1.14 APE12-dist-in 12.1917 APE11-dist-in 10.8889 APE10-dist-out 9.9307 APE9-dist-out 11.3954 C290A,C393A TPO288 TPO288 XRAY 2.04 0.188 0.226 A 285.0 265.0 0 26 26 0 [[133, 383]] 1.0 6r4c Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6R4DA O14965 127 391 403.0 ADP:501,JRW:505 ATPlike,Allosteric Inactive DFGin 5.4128 15.0606 BLAminus -136.32, -175.95 60.26, 82.3 -97.39, 21.73 280.16, 71.96 -61.32, -30.02 in-in in 9.3772 Saltbr-in 2.9356 HRD-in -84.35, -49.77 70.9, 2.54 in-in-out SNCiio in-out ActLoopNT-in 2.8984 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -109.88, -49.72 APE9-dihe-na -75.41, -134.11 APE8-dihe-in -89.35, 144.76 APE8-rot-out 181.5 APE67-dihe-in -55.31, -28.98 -80.38, -7.16 APE12-dist-in 12.1691 APE11-dist-in 10.3905 APE10-dist-out 11.4777 APE9-dist-out 10.5886 C290A,C393A TPO288 TPO288 XRAY 2.009 0.197 0.233 A 285.0 265.0 0 26 26 0 [[133, 383]] 1.0 6r4d Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 7ZTLA O14965 126 389 403.0 ADP:501,BCN:506 ATPlike,Allosteric Active DFGin 5.6229 15.1084 BLAminus -131.55, 179.55 58.91, 75.38 -87.97, 22.52 281.42, 69.29 -65.3, -21.25 in-in in 9.2252 Saltbr-in 2.815 HRD-in -81.87, -52.88 75.2, 3.05 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.79, 177.44 APE9-dihe-na 70.08, -157.96 APE8-dihe-in -126.05, 125.84 APE8-rot-in 309.73 APE67-dihe-in -58.88, -23.16 -51.84, -48.56 APE12-dist-in 8.1263 APE11-dist-in 10.6011 APE10-dist-in 5.3541 APE9-dist-in 3.7652 C290A,K339C,C393A TPO288 TPO288 XRAY 1.9 0.165 0.193 A 309.0 264.0 0 26 26 0 [[133, 383]] 1.0 7ztl Homo sapiens CAMK_AURKA_HUMAN CAMK 4.2e-78 268.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8OF5A O14965 126 390 403.0 ADP:501,MPO:505 ATPlike,Allosteric Inactive DFGin 5.5613 15.0734 BLAminus -147.6, 177.58 63.9, 71.93 -82.69, 26.74 280.62, 72.05 -50.28, -40.53 in-in in 9.3763 Saltbr-in 2.7388 HRD-in -82.42, -53.84 70.6, 7.86 in-in-out SNCiio in-out ActLoopNT-in 2.9866 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na 65.3, 47.54 APE9-dihe-na -68.67, -176.82 APE8-dihe-in -69.15, 145.4 APE8-rot-out 54.1 APE67-dihe-in -51.26, -26.94 -88.64, -16.45 APE12-dist-out 18.2387 APE11-dist-out 20.5865 APE10-dist-out 23.6119 APE9-dist-out 27.9049 C290A,N332A,Q335A,C393A None None XRAY 1.97 0.186 0.235 A 285.0 265.0 0 26 26 0 [[133, 383]] 1.0 8of5 Homo sapiens CAMK_AURKA_HUMAN CAMK 3.1e-78 268.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C14A O14965 126 389 403.0 ADP:417,T5L:418,T0L:424 ATPlike,Allosteric,Allosteric Inactive DFGin 5.6307 14.7937 BLAminus -132.92, -178.64 59.29, 78.11 -87.91, 19.69 280.37, 75.08 -49.0, -40.94 in-in in 9.3228 Saltbr-in 2.7489 HRD-in -74.47, -52.26 68.72, 1.37 in-in-out SNCiio in-out ActLoopNT-in 2.8228 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -125.05, 2.89 APE9-dihe-na -76.04, 173.54 APE8-dihe-in -47.98, 133.45 APE8-rot-in 311.24 APE67-dihe-in -48.21, -32.08 -100.5, -9.07 APE12-dist-in 9.0819 APE11-dist-in 13.0305 APE10-dist-out 15.5933 APE9-dist-out 10.8925 None TPO288 TPO288 XRAY 1.93 0.182 0.194 A 272.0 264.0 0 26 26 0 [[133, 383]] 1.0 8c14 Homo sapiens CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C15A O14965 126 388 403.0 ADP:401,T4C:404,T5L:405 ATPlike,Allosteric,Allosteric Inactive DFGin 5.6579 14.941 BLAminus -128.39, 176.76 57.21, 80.94 -90.54, 19.4 280.16, 77.64 -46.89, -42.14 in-in in 9.3562 Saltbr-in 2.9117 HRD-in -70.87, -48.88 65.09, -5.38 in-in-out SNCiio in-out ActLoopNT-in 2.8481 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -170.75 APE8-dihe-in -66.3, 161.07 APE8-rot-out 73.39 APE67-dihe-in -37.43, -35.12 -85.37, -6.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.144 C290A None None XRAY 2.41 0.199 0.207 A 265.0 259.0 4 26 22 4 [[133, 383]] 1.0 8c15 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1FA O14965 126 388 403.0 ADP:401,T5L:409,T2O:417 ATPlike,Allosteric,Allosteric Inactive DFGin 5.4716 14.6337 BLAminus -130.51, -175.69 56.68, 77.24 -89.7, 19.52 279.6, 79.65 -52.03, -32.93 in-in in 9.3024 Saltbr-in 2.8107 HRD-in -73.98, -48.91 69.8, -1.54 in-in-out SNCiio in-out ActLoopNT-in 2.8765 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -138.04 APE8-dihe-in -67.54, 164.12 APE8-rot-out 77.8 APE67-dihe-in -44.07, -35.33 -85.42, 0.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.5223 C290A None None XRAY 1.924 0.206 0.234 A 265.0 258.0 5 26 21 5 [[133, 383]] 1.0 8c1f Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1IA O14965 126 388 403.0 ADP:401,T1L:404,T5L:405 ATPlike,Allosteric,Allosteric Inactive DFGin 5.5241 14.838 BLAminus -129.39, -179.52 57.08, 78.15 -89.88, 20.87 280.11, 76.95 -51.9, -37.66 in-in in 9.3549 Saltbr-in 2.9056 HRD-in -72.05, -49.31 67.09, -4.7 in-in-out SNCiio in-out ActLoopNT-in 2.8215 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -172.24 APE8-dihe-in -59.73, 161.33 APE8-rot-out 79.24 APE67-dihe-in -39.82, -36.32 -87.05, -1.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.3413 C290A None None XRAY 2.81 0.213 0.234 A 265.0 260.0 3 26 23 3 [[133, 383]] 1.0 8c1i Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1MA O14965 127 389 403.0 T4X:402,ADP:404 Allosteric,ATPlike Inactive DFGin 5.6001 15.2723 BLAminus -122.0, 174.82 64.71, 68.72 -82.42, 30.82 279.23, 73.39 -59.87, -38.7 in-in in 9.6473 Saltbr-in 3.0527 HRD-in -66.75, -51.37 63.02, 9.93 in-in-out SNCiio in-out ActLoopNT-in 2.8953 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -144.61, 52.2 APE9-dihe-na -98.47, -158.53 APE8-dihe-in -77.97, 114.41 APE8-rot-out 83.32 APE67-dihe-in -36.94, -36.23 -77.28, -23.95 APE12-dist-in 9.5276 APE11-dist-in 12.9895 APE10-dist-out 15.7549 APE9-dist-out 10.6188 None TPO288 TPO288 XRAY 2.84 0.253 0.269 A 273.0 263.0 0 26 26 0 [[133, 383]] 1.0 8c1m Homo sapiens CAMK_AURKA_HUMAN CAMK 6.5e-80 274.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1DA O14965 127 388 403.0 T2F:401,ADP:402,T5L:405 Allosteric,ATPlike,Allosteric Inactive DFGin 5.5903 14.7701 BLAminus -129.39, 179.64 57.3, 80.97 -92.88, 23.53 280.13, 79.47 -56.16, -33.44 in-in in 9.3061 Saltbr-in 2.9364 HRD-in -72.1, -50.49 67.69, -1.24 in-in-out SNCiio in-out ActLoopNT-in 2.7964 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 144.85 APE8-dihe-in -64.26, 154.27 APE8-rot-out 88.6 APE67-dihe-in -39.49, -36.75 -82.32, -6.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.088 C290A None None XRAY 2.115 0.212 0.238 A 265.0 259.0 3 26 23 3 [[133, 383]] 1.0 8c1d Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1GA O14965 127 388 403.0 T3I:401,ADP:402,T5L:406 Allosteric,ATPlike,Allosteric Inactive DFGin 5.5437 14.882 BLAminus -128.11, -179.39 58.87, 76.11 -85.79, 22.41 279.68, 78.85 -51.87, -42.67 in-in in 9.2229 Saltbr-in 2.92 HRD-in -78.13, -46.93 64.28, -1.01 in-in-out SNCiio in-out ActLoopNT-in 2.8594 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -158.88 APE8-dihe-in -70.7, 159.97 APE8-rot-out 74.34 APE67-dihe-in -36.07, -37.71 -84.84, -3.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.3547 C290A None None XRAY 1.96 0.2 0.225 A 265.0 258.0 4 26 22 4 [[133, 383]] 1.0 8c1g Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1HA O14965 127 388 403.0 T3U:401,ADP:402,T5L:405 Allosteric,ATPlike,Allosteric Inactive DFGin 5.6033 14.806 BLAminus -133.2, 171.3 67.89, 80.13 -90.96, 20.95 279.09, 80.15 -47.86, -43.49 in-in in 9.2738 Saltbr-in 3.0016 HRD-in -69.34, -50.65 67.03, -6.54 in-in-out SNCiio in-out ActLoopNT-in 2.8653 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -157.54 APE8-dihe-in -70.83, 158.42 APE8-rot-out 74.14 APE67-dihe-in -36.91, -39.82 -81.98, -5.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.5277 C290A None None XRAY 2.233 0.213 0.245 A 265.0 258.0 4 26 22 4 [[133, 383]] 1.0 8c1h Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1KA O14965 127 388 403.0 T4O:401,ADP:402,T5L:405 Allosteric,ATPlike,Allosteric Inactive DFGin 5.3967 14.7974 BLAminus -136.92, -175.3 58.28, 79.92 -93.28, 13.0 269.57, 89.35 -50.4, -38.71 in-in in 9.6032 Saltbr-in 3.1142 HRD-in -64.38, -56.58 69.39, -9.24 in-in-out SNCiio in-out ActLoopNT-in 3.0088 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na 39.31, -114.48 APE9-dihe-na 117.85, -67.49 APE8-dihe-in -136.08, 128.66 APE8-rot-out 19.12 APE67-dihe-in -37.03, -29.23 -73.31, -14.52 APE12-dist-in 9.2582 APE11-dist-in 12.9138 APE10-dist-out 12.6881 APE9-dist-out 10.8352 C290A None None XRAY 2.43 0.219 0.242 A 273.0 262.0 0 26 26 0 [[133, 383]] 1.0 8c1k Homo sapiens CAMK_AURKA_HUMAN CAMK 8e-79 270.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8PR7D O14965 126 388 403.0 ADP:501 ATPlike Inactive DFGin 6.9163 17.6819 BLBminus -119.47, -172.43 57.55, 67.82 -98.5, 138.77 288.48, 69.88 152.2, -37.73 out-none out 11.7807 Saltbr-none 999.0 HRD-in -89.57, -45.69 63.63, 4.27 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, 178.01 APE9-dihe-na 51.17, 13.86 APE8-dihe-out -88.74, -9.17 APE8-rot-none 999.0 APE67-dihe-in -65.89, -30.04 -136.83, 2.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.9294 APE9-dist-out 11.3958 D274N,C290A,N332A,Q335A,T347A,D350A,C393A None None XRAY 2.76 0.205 0.256 D 283.0 251.0 12 26 14 12 [[133, 383]] 1.0 8pr7 Homo sapiens CAMK_AURKA_HUMAN CAMK 3e-77 265.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5ODTA O14965 126 392 403.0 ADP:501 ATPlike Inactive DFGin 6.7171 16.9598 None -121.13, 4.47 -111.78, 32.81 -79.52, 164.76 286.94, 96.78 78.48, -128.28 out-out out 11.7478 Saltbr-out 10.767 HRD-out -137.93, 83.59 -73.55, -34.72 out-out-out SNCooo out-out ActLoopNT-out 17.7885 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, -15.28 APE9-dihe-na -98.55, 177.35 APE8-dihe-out 65.78, -46.63 APE8-rot-none 999.0 APE67-dihe-in -47.55, -29.4 -45.89, -32.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 24.8668 APE9-dist-out 13.4366 D274N,C290A,C393A None None XRAY 2.021 0.179 0.211 A 283.0 258.0 9 26 17 9 [[133, 383]] 1.0 5odt Homo sapiens CAMK_AURKA_HUMAN CAMK 5.4e-78 267.8 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 9GUCA O14965 124 391 403.0 ADP:501,AMP:503 ATPlike,Allosteric Inactive DFGin 7.1772 17.543 None -98.47, -53.8 -99.76, 123.69 -123.57, 999.0 272.41, 116.36 999.0, 999.0 out-none out 10.8811 Saltbr-none 999.0 HRD-in -77.17, -58.19 77.29, 1.39 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na -78.2, -27.21 APE9-dihe-na 141.47, -167.5 APE8-dihe-in -95.93, 123.55 APE8-rot-in 299.51 APE67-dihe-in -57.72, -20.14 -51.84, -47.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.7077 C290A,C393A None None XRAY 2.1 0.193 0.232 A 285.0 256.0 12 26 14 12 [[133, 383]] 1.0 9guc Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5L8JA O14965 126 391 403.0 ADP:60501 ATPlike Inactive DFGinter 6.0388 8.8115 None -121.42, -0.81 -92.81, -3.45 60.99, 19.44 297.14, 26.84 -77.84, 60.22 out-out out 13.2014 Saltbr-out 9.5877 HRD-out -100.39, 154.9 -77.66, -154.82 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 16.48 APE8-rot-out 62.75 APE67-dihe-in -57.65, -20.32 -54.21, -40.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C290A,C393A TPO288 TPO288 XRAY 1.68 0.201 0.231 A 285.0 253.0 13 26 13 13 [[133, 383]] 1.0 5l8j Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5L8KA O14965 126 392 403.0 ADP:60501 ATPlike Inactive DFGinter 5.9336 8.6956 None -123.53, 3.87 -94.88, 4.13 51.12, 25.43 307.6, 8.65 -83.23, 69.32 out-out out 12.9065 Saltbr-out 9.1369 HRD-out -94.24, 154.96 -82.75, -161.39 out-out-out SNCooo out-out ActLoopNT-out 5.2619 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -60.54, 152.13 APE9-dihe-na 121.57, -104.82 APE8-dihe-in -138.45, 120.03 APE8-rot-in 300.38 APE67-dihe-in -56.47, -22.96 -75.46, -21.38 APE12-dist-out 14.1901 APE11-dist-out 17.8848 APE10-dist-out 19.7221 APE9-dist-out 13.7291 C290A,C393A TPO288 TPO288 XRAY 1.79 0.192 0.235 A 285.0 267.0 0 26 26 0 [[133, 383]] 1.0 5l8k Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5L8LA O14965 126 389 403.0 ADP:60501 ATPlike Inactive DFGinter 5.6468 8.8822 None -117.8, 6.57 -92.89, -1.12 53.22, 20.44 289.58, 36.26 -84.0, 68.46 out-out out 12.5405 Saltbr-out 9.0265 HRD-out -99.09, 148.91 -94.35, -164.8 out-out-out SNCooo out-out ActLoopNT-out 5.3927 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -75.26, -165.41 APE9-dihe-na -67.89, -63.26 APE8-dihe-out -124.39, -179.64 APE8-rot-out 64.28 APE67-dihe-in -57.8, -26.84 -83.02, -0.31 APE12-dist-in 11.1091 APE11-dist-out 16.5204 APE10-dist-out 14.4907 APE9-dist-out 14.6386 C290A,C393A TPO288 TPO288 XRAY 1.67 0.193 0.223 A 285.0 264.0 0 26 26 0 [[133, 383]] 1.0 5l8l Homo sapiens CAMK_AURKA_HUMAN CAMK 9.4e-79 270.3 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8PR7A O14965 124 389 403.0 ADP:501 ATPlike Inactive DFGinter 5.0698 10.2727 None -105.95, 148.75 -124.79, 28.7 -129.06, 999.0 303.51, 120.23 999.0, 999.0 out-out out 12.4819 Saltbr-out 11.7057 HRD-out 52.78, 71.6 -97.43, 142.22 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 47.95, -115.05 APE9-dihe-na -125.01, 9.37 APE8-dihe-out -40.29, -50.01 APE8-rot-out 85.86 APE67-dihe-in -55.11, -34.07 -62.49, -38.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.8319 D274N,C290A,N332A,Q335A,T347A,D350A,C393A None None XRAY 2.76 0.205 0.256 A 283.0 253.0 13 26 13 13 [[133, 383]] 1.0 8pr7 Homo sapiens CAMK_AURKA_HUMAN CAMK 3e-77 265.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2WQEA O14965 127 388 403.0 ADP:1389,ADP:1390,ADP:1391 ATPlike,ATPlike,ATPlike Inactive None 999.0 999.0 None -107.12, -44.35 28.24, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 out-none out 12.4276 Saltbr-none 999.0 HRD-out -82.99, 160.23 -97.32, -44.1 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -56.47 APE8-dihe-out -79.62, -22.51 APE8-rot-in 267.0 APE67-dihe-in -40.62, -26.16 -46.48, -55.39 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.7962 S155R None None XRAY 2.5 0.206 0.251 A 262.0 241.0 21 26 10 16 [[133, 383]] 1.0 2wqe Homo sapiens CAMK_AURKA_HUMAN CAMK 9.7e-80 273.5 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK CAMK2A KCC2A_HUMAN 7UJSA Q9UQM7 7 274 478.0 ADP:301 ATPlike Active DFGin 6.2091 15.1635 BLAminus -142.86, -173.92 52.2, 80.06 -100.62, 24.47 291.74, 81.6 -63.11, -26.23 in-in in 9.5125 Saltbr-in 3.4437 HRD-in -76.47, -52.69 80.52, -7.0 in-in-in SNCiii in-in ActLoopNT-in 2.9518 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.88, 140.41 APE9-dihe-na 133.49, -148.09 APE8-dihe-in -128.43, 117.33 APE8-rot-in 305.05 APE67-dihe-in -59.07, -26.67 -36.29, -54.08 APE12-dist-in 10.1975 APE11-dist-in 11.5048 APE10-dist-in 5.7786 APE9-dist-in 3.6826 Q223K None None XRAY 2.75 0.201 0.262 A 268.0 268.0 0 28 28 0 [[13, 271]] 1.0 7ujs Homo sapiens CAMK_CAMK2A_HUMAN CAMK 1e-96 329.1 1.0 256.0 256.0 155 156 157 159 161 42 60 64 132 134 133 135.0 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 7UJPA Q9UQM7 7 274 478.0 ADP:301 ATPlike Active DFGin 6.7748 14.6398 BLAminus -129.88, 174.11 65.35, 73.67 -96.28, 29.41 284.7, 81.79 -65.3, -26.47 in-in in 8.5267 Saltbr-in 2.9028 HRD-in -76.38, -51.72 77.74, -11.0 in-in-in SNCiii in-in ActLoopNT-in 2.8754 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.94, 142.69 APE9-dihe-na 139.08, -169.53 APE8-dihe-in -115.65, 123.25 APE8-rot-in 308.77 APE67-dihe-in -69.44, -15.11 -33.38, -56.34 APE12-dist-in 10.4685 APE11-dist-in 11.3966 APE10-dist-in 5.657 APE9-dist-in 3.521 D135N,Q223K None None XRAY 2.56 0.234 0.281 A 268.0 268.0 0 28 28 0 [[13, 271]] 1.0 7ujp Homo sapiens CAMK_CAMK2A_HUMAN CAMK 9.3e-96 326.0 1.0 256.0 256.0 155 156 157 159 161 42 60 64 132 134 133 135.0 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CHEK2 CHK2_HUMAN 2CN5A O96017 209 504 543.0 ADP:61509 ATPlike Inactive DFGin 6.789 14.4943 BLAminus -135.2, 179.16 64.2, 79.37 -102.1, 20.75 283.06, 77.6 -58.46, -25.36 in-out in 9.9172 Saltbr-out 4.3439 HRD-in -79.96, -48.23 69.59, 1.14 out-in-out SNCoio in-out ActLoopNT-in 2.8477 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -76.74, 7.44 APE9-dihe-na -76.93, 179.76 APE8-dihe-out 76.66, 47.76 APE8-rot-out 216.78 APE67-dihe-in -44.78, -36.74 -82.05, -7.37 APE12-dist-out 25.3627 APE11-dist-out 27.5187 APE10-dist-out 29.8721 APE9-dist-out 32.7677 None None None XRAY 2.25 0.201 0.24 A 329.0 282.0 14 27 27 0 [[220, 486]] 1.0 2cn5 Homo sapiens CAMK_CHEK2_HUMAN CAMK 2.1e-85 292.1 1.0 256.0 256.0 367 368 369 371 373 249 273 277 344 346 345 347.0 409 394 389 388 387 386 385 384 383 302 Serine/threonine-protein kinase Chk2
CAMK DAPK1 DAPK1_HUMAN 2W4JA P53355 2 277 1430.0 ADP:1278 ATPlike Inactive DFGin 6.5864 13.8954 BLAminus -123.3, -175.29 63.17, 81.91 -95.29, 20.87 287.95, 79.94 -69.92, -15.2 in-in in 8.9915 Saltbr-in 2.7449 HRD-in -74.79, -47.39 66.71, 11.49 in-in-out SNCiio in-out ActLoopNT-in 2.9313 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -155.28, 112.88 APE9-dihe-na -96.93, -134.15 APE8-dihe-in -90.19, 126.44 APE8-rot-in 297.68 APE67-dihe-in -65.36, -18.9 -46.88, -44.63 APE12-dist-in 10.3574 APE11-dist-out 6.5388 APE10-dist-out 9.6648 APE9-dist-in 4.9924 None None None XRAY 1.3 0.132 0.159 A 277.0 276.0 0 27 27 0 [[13, 275]] 1.0 2w4j Homo sapiens CAMK_DAPK1_HUMAN CAMK 4.9e-95 323.6 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3EH9A P53355 2 277 1430.0 ADP:60001 ATPlike Inactive DFGin 6.7195 14.1062 BLAminus -121.08, 178.11 65.97, 83.53 -97.47, 22.9 284.12, 79.86 -68.8, -21.44 in-in in 9.5147 Saltbr-in 3.0884 HRD-in -77.18, -44.06 68.03, 9.36 in-in-out SNCiio in-out ActLoopNT-in 2.8993 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -93.65, 114.44 APE9-dihe-na -90.95, -143.91 APE8-dihe-in -83.41, 125.11 APE8-rot-in 299.02 APE67-dihe-in -61.0, -22.55 -46.4, -40.51 APE12-dist-in 11.1774 APE11-dist-out 5.7723 APE10-dist-out 9.4565 APE9-dist-in 4.5563 None None None XRAY 1.7 0.18 0.217 A 294.0 274.0 2 27 27 0 [[13, 275]] 1.0 3eh9 Homo sapiens CAMK_DAPK1_HUMAN CAMK 6.1e-95 323.3 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3F5GA P53355 2 277 1430.0 ADP:60001 ATPlike Inactive DFGin 6.6849 13.9682 BLAminus -120.45, 179.24 65.08, 83.1 -97.05, 24.31 287.76, 77.76 -68.45, -21.11 in-in in 9.307 Saltbr-in 2.7967 HRD-in -76.76, -45.85 68.91, 8.76 in-in-out SNCiio in-out ActLoopNT-in 2.914 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -92.45, 115.11 APE9-dihe-na -89.86, -138.22 APE8-dihe-in -85.51, 124.34 APE8-rot-in 301.38 APE67-dihe-in -61.82, -27.25 -45.2, -42.29 APE12-dist-in 11.0239 APE11-dist-out 5.7744 APE10-dist-out 9.48 APE9-dist-in 4.6227 None None None XRAY 1.85 0.188 0.244 A 294.0 276.0 0 27 27 0 [[13, 275]] 1.0 3f5g Homo sapiens CAMK_DAPK1_HUMAN CAMK 6.1e-95 323.3 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 2W4KA P53355 2 302 1430.0 ADP:1303 ATPlike Active DFGin 6.672 14.1782 BLAminus -119.76, -176.11 66.35, 79.87 -97.37, 22.41 282.66, 74.96 -63.58, -22.08 in-in in 9.1099 Saltbr-in 2.8291 HRD-in -72.34, -46.15 68.63, 4.94 in-in-in SNCiii in-in ActLoopNT-in 2.8661 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.51, 175.21 APE9-dihe-na 86.37, -178.83 APE8-dihe-in -92.32, 120.41 APE8-rot-in 301.2 APE67-dihe-in -65.94, -16.49 -43.92, -47.7 APE12-dist-in 9.2041 APE11-dist-in 12.2877 APE10-dist-in 6.8203 APE9-dist-in 5.1317 None None None XRAY 1.9 0.195 0.228 A 302.0 301.0 0 27 27 0 [[13, 275]] 1.0 2w4k Homo sapiens CAMK_DAPK1_HUMAN CAMK 6.8e-95 323.2 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3GU6A P53355 2 277 1430.0 ADP:60296 ATPlike Inactive DFGin 6.703 14.0148 BLAminus -123.16, -179.19 61.96, 78.37 -92.65, 24.29 287.26, 76.41 -68.7, -18.31 in-in in 9.0833 Saltbr-in 2.7221 HRD-in -78.16, -47.73 70.74, 4.81 in-in-out SNCiio in-out ActLoopNT-in 2.9167 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -153.98, 117.17 APE9-dihe-na -91.62, -149.81 APE8-dihe-in -81.71, 126.34 APE8-rot-in 293.82 APE67-dihe-in -55.19, -26.27 -45.69, -42.2 APE12-dist-in 10.0084 APE11-dist-out 6.6006 APE10-dist-out 9.4175 APE9-dist-in 4.349 Q23V None None XRAY 1.49 0.185 0.213 A 295.0 276.0 0 27 27 0 [[13, 275]] 1.0 3gu6 Homo sapiens CAMK_DAPK1_HUMAN CAMK 2.1e-94 321.5 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 3GU7A P53355 2 277 1430.0 ADP:60296 ATPlike Inactive DFGin 6.697 14.1214 BLAminus -119.64, -175.75 62.96, 82.16 -94.9, 24.89 284.57, 77.57 -70.06, -20.41 in-in in 9.2485 Saltbr-in 2.7866 HRD-in -79.97, -44.14 64.75, 4.23 in-in-out SNCiio in-out ActLoopNT-in 2.943 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -162.1, 115.0 APE9-dihe-na -94.82, -140.46 APE8-dihe-in -83.81, 124.48 APE8-rot-in 298.21 APE67-dihe-in -60.5, -27.71 -46.69, -42.88 APE12-dist-in 11.1998 APE11-dist-out 6.3832 APE10-dist-out 9.4382 APE9-dist-in 4.626 Q23V None None XRAY 1.9 0.173 0.228 A 295.0 276.0 0 27 27 0 [[13, 275]] 1.0 3gu7 Homo sapiens CAMK_DAPK1_HUMAN CAMK 2.1e-94 321.5 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK DAPK1 DAPK1_HUMAN 2XUUA P53355 2 302 1430.0 ADP:1303 ATPlike Active DFGin 6.8137 14.2995 BLAminus -117.01, 179.93 67.97, 81.82 -97.7, 27.63 286.42, 73.81 -75.99, -13.96 in-in in 9.0474 Saltbr-in 2.6227 HRD-in -76.48, -45.49 71.86, 3.84 in-in-in SNCiii in-in ActLoopNT-in 2.8741 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -168.39, 167.91 APE9-dihe-na 89.82, 178.63 APE8-dihe-in -101.18, 124.0 APE8-rot-in 296.23 APE67-dihe-in -60.21, -22.55 -44.54, -47.64 APE12-dist-in 8.87 APE11-dist-in 11.7269 APE10-dist-in 6.4064 APE9-dist-in 5.145 E182A None None XRAY 1.8 0.179 0.226 A 334.0 301.0 0 27 27 0 [[13, 275]] 1.0 2xuu Homo sapiens CAMK_DAPK1_HUMAN CAMK 1.4e-94 322.3 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK MAPKAPK2 MAPK2_HUMAN 1NY3A P49137 46 345 400.0 ADP:401 ATPlike Inactive DFGin 4.2134 13.9181 BLAminus -139.11, 173.49 82.65, 112.5 -121.18, 20.23 280.18, 65.28 -53.92, -18.87 out-out out 10.0385 Saltbr-out 6.1056 HRD-in -63.84, -48.41 55.55, 34.09 out-in-none SNCoin in-none ActLoopNT-in 2.9814 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -47.32, -19.47 999.0, 98.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.0 0.27 0.292 A 400.0 277.0 23 27 18 9 [[63, 325]] 1.0 1ny3 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 6.7e-80 274.2 3.0 256.0 254.0 206 207 208 210 212 93 104 108 183 185 184 186.0 245 233 228 227 226 225 224 223 222 139 MAP kinase-activated protein kinase 2
CAMK PASK PASK_HUMAN 3DLSA Q96RG2 982 1266 1323.0 ADP:1 ATPlike Active DFGin 6.0012 14.2045 BLAminus -129.0, 178.94 63.52, 79.16 -100.96, 27.03 282.44, 72.76 -70.92, -15.42 in-in in 8.6547 Saltbr-in 2.6046 HRD-naE -71.55, -40.2 72.7, 1.22 in-in-in SNCiii in-in ActLoopNT-in 2.9929 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.6, 5.88 APE9-dihe-na -96.65, -154.85 APE8-dihe-in -98.92, 122.93 APE8-rot-in 302.12 APE67-dihe-in -72.66, -14.95 -65.45, -19.89 APE12-dist-in 10.2025 APE11-dist-in 10.5743 APE10-dist-in 5.0607 APE9-dist-in 3.4509 None None None XRAY 2.3 0.244 0.297 A 335.0 285.0 0 27 27 0 [[999, 1251]] 1.0 3dls Homo sapiens CAMK_PASK_HUMAN CAMK 2.7e-67 232.8 1.0 256.0 256.0 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128.0 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN 3DLSB Q96RG2 982 1267 1323.0 ADP:2 ATPlike Active DFGin 6.1002 14.0868 BLAminus -126.55, 179.43 61.31, 80.64 -98.16, 22.24 284.4, 71.69 -72.83, -6.95 in-in in 8.3458 Saltbr-in 2.6768 HRD-naE -67.25, -43.38 72.94, 0.56 in-in-in SNCiii in-in ActLoopNT-in 2.9211 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.86, 22.09 APE9-dihe-na -121.63, -155.86 APE8-dihe-in -97.56, 124.97 APE8-rot-in 306.83 APE67-dihe-in -68.7, -17.81 -61.84, -27.67 APE12-dist-in 10.243 APE11-dist-in 10.6876 APE10-dist-in 5.1494 APE9-dist-in 3.5208 None None None XRAY 2.3 0.244 0.297 B 335.0 280.0 6 27 27 0 [[999, 1251]] 1.0 3dls Homo sapiens CAMK_PASK_HUMAN CAMK 2.7e-67 232.8 1.0 256.0 256.0 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128.0 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN 3DLSC Q96RG2 982 1267 1323.0 ADP:3 ATPlike Active DFGin 6.5494 14.1362 BLAminus -121.24, -178.98 61.8, 81.93 -100.03, 24.34 279.06, 77.86 -70.4, -24.84 in-in in 8.2856 Saltbr-in 2.707 HRD-naE -75.53, -39.96 73.3, -0.15 in-in-in SNCiii in-in ActLoopNT-in 2.8084 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -109.16, 23.96 APE9-dihe-na -111.98, -161.37 APE8-dihe-in -95.46, 124.23 APE8-rot-in 302.16 APE67-dihe-in -72.29, -18.02 -57.94, -30.36 APE12-dist-in 9.9796 APE11-dist-in 10.4372 APE10-dist-in 4.9616 APE9-dist-in 3.4664 None None None XRAY 2.3 0.244 0.297 C 335.0 281.0 5 27 27 0 [[999, 1251]] 1.0 3dls Homo sapiens CAMK_PASK_HUMAN CAMK 2.7e-67 232.8 1.0 256.0 256.0 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128.0 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN 3DLSD Q96RG2 982 1266 1323.0 ADP:4 ATPlike Active DFGin 5.9889 14.0366 BLAminus -119.78, -174.43 57.15, 82.44 -96.61, 20.08 283.36, 68.59 -63.18, -13.75 in-in in 8.5958 Saltbr-in 2.6735 HRD-naE -66.59, -43.13 75.45, -3.58 in-in-in SNCiii in-in ActLoopNT-in 2.8117 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.17, 8.76 APE9-dihe-na -100.36, -154.44 APE8-dihe-in -94.34, 129.8 APE8-rot-in 309.84 APE67-dihe-in -63.24, -17.05 -59.73, -34.41 APE12-dist-in 10.5787 APE11-dist-in 10.6015 APE10-dist-in 5.2119 APE9-dist-in 3.3182 None None None XRAY 2.3 0.244 0.297 D 335.0 284.0 1 27 27 0 [[999, 1251]] 1.0 3dls Homo sapiens CAMK_PASK_HUMAN CAMK 2.7e-67 232.8 1.0 256.0 256.0 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128.0 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN 3DLSE Q96RG2 982 1267 1323.0 ADP:5 ATPlike Active DFGin 6.3512 14.1127 BLAminus -115.03, 172.38 61.43, 82.92 -98.38, 26.76 287.19, 66.36 -61.94, -22.57 in-in in 8.272 Saltbr-in 3.0153 HRD-naE -64.64, -41.08 75.56, -14.47 in-in-in SNCiii in-in ActLoopNT-in 2.924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.8, 6.63 APE9-dihe-na -93.38, -160.98 APE8-dihe-in -92.63, 131.98 APE8-rot-in 304.09 APE67-dihe-in -71.09, -14.17 -58.49, -32.88 APE12-dist-in 10.767 APE11-dist-in 10.575 APE10-dist-in 5.0724 APE9-dist-in 3.4232 None None None XRAY 2.3 0.244 0.297 E 335.0 282.0 4 27 27 0 [[999, 1251]] 1.0 3dls Homo sapiens CAMK_PASK_HUMAN CAMK 2.7e-67 232.8 1.0 256.0 256.0 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128.0 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK PASK PASK_HUMAN 3DLSF Q96RG2 982 1266 1323.0 ADP:6 ATPlike Active DFGin 6.2081 14.428 BLAminus -120.86, -179.45 54.8, 74.61 -87.61, 27.75 280.29, 66.66 -72.72, -14.22 in-in in 8.4923 Saltbr-in 2.8794 HRD-naE -64.59, -48.9 86.1, -8.79 in-in-in SNCiii in-in ActLoopNT-in 2.7043 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.3, 4.74 APE9-dihe-na -89.15, -152.34 APE8-dihe-in -104.88, 132.7 APE8-rot-in 302.97 APE67-dihe-in -72.03, -17.52 -62.59, -27.45 APE12-dist-in 10.486 APE11-dist-in 10.5471 APE10-dist-in 5.1005 APE9-dist-in 3.2843 None None None XRAY 2.3 0.244 0.297 F 335.0 281.0 4 27 27 0 [[999, 1251]] 1.0 3dls Homo sapiens CAMK_PASK_HUMAN CAMK 2.7e-67 232.8 1.0 256.0 256.0 1145 1146 1147 1149 1151 1028 1052 1056 1125 1127 1126 1128.0 1185 1172 1167 1166 1165 1164 1163 1162 1161 1082 PAS domain-containing serine/threonine-protein kinase
CAMK STK17B ST17B_HUMAN 6QF4A O94768 18 308 372.0 ADP:405 ATPlike Inactive DFGin 6.2517 14.5888 BLAminus -138.0, 178.42 64.68, 88.16 -110.19, 27.69 285.51, 77.31 -64.42, -20.01 out-out out 10.2932 Saltbr-out 4.3956 HRD-in -72.0, -51.78 71.09, 16.02 out-in-out SNCoio in-out ActLoopNT-in 3.1294 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioo APE10-dihe-na -151.1, 167.46 APE9-dihe-na 109.33, 178.09 APE8-dihe-in -61.1, 118.93 APE8-rot-in 322.5 APE67-dihe-in -69.8, -8.25 -54.96, -33.39 APE12-dist-none 999.0 APE11-dist-in 12.911 APE10-dist-out 10.081 APE9-dist-out 7.8387 None None None XRAY 2.495 0.187 0.227 A 327.0 287.0 4 27 23 4 [[32, 293]] 1.0 6qf4 Homo sapiens CAMK_STK17B_HUMAN CAMK 1.4e-81 279.8 4.0 256.0 253.0 178 179 180 182 184 62 80 84 155 157 156 158.0 217 205 200 199 198 197 196 195 194 111 Serine/threonine-protein kinase 17B
CAMK STK17B ST17B_HUMAN 7Q7CA O94768 25 297 372.0 ADP:60402 ATPlike None DFGin 5.6722 13.9829 BLAminus -146.28, 174.77 69.66, 80.54 -103.01, 24.61 291.62, 86.01 -65.04, -13.43 in-in in 9.403 Saltbr-in 3.3501 HRD-in -84.64, -49.74 76.32, -16.47 in-in-none SNCiin in-none ActLoopNT-in 3.2975 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 143.13 APE8-rot-in 309.53 APE67-dihe-in -65.37, -16.14 -54.33, -43.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.85 0.21 0.238 A 327.0 265.0 8 27 19 8 [[32, 293]] 1.0 7q7c Homo sapiens CAMK_STK17B_HUMAN CAMK 1.4e-81 279.8 4.0 256.0 253.0 178 179 180 182 184 62 80 84 155 157 156 158.0 217 205 200 199 198 197 196 195 194 111 Serine/threonine-protein kinase 17B
CK1 CSNK1D KC1D_HUMAN 6RU7A P48730 3 294 415.0 ADP:60301 Type1.5_Back Active DFGin 6.392 15.1253 BLAminus -134.23, -173.24 59.44, 80.86 -96.06, 22.96 285.76, 78.27 -62.92, -27.34 in-in in 7.9707 Saltbr-in 2.803 HRD-in -82.18, -50.23 72.61, 5.15 in-in-in SNCiii in-in ActLoopNT-in 2.8844 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -114.24, 126.6 APE9-dihe-na 114.96, -145.11 APE8-dihe-in -115.28, 122.22 APE8-rot-in 302.31 APE67-dihe-in -56.73, -38.36 -50.64, -46.9 APE12-dist-in 12.3807 APE11-dist-in 12.1789 APE10-dist-in 6.8342 APE9-dist-in 3.5112 None None None XRAY 2.08 0.177 0.218 A 296.0 292.0 0 35 35 0 [[9, 275]] 1.0 6ru7 Homo sapiens CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1.0 262.0 262.0 148 149 150 152 154 38 52 56 125 127 126 128.0 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RU7B P48730 3 294 415.0 ADP:60301 Type1.5_Back Active DFGin 6.6176 14.988 BLAminus -130.01, -176.4 60.72, 81.81 -97.28, 21.17 286.1, 78.89 -61.41, -29.58 in-in in 7.7948 Saltbr-in 2.9121 HRD-in -81.31, -50.84 72.75, 6.38 in-in-in SNCiii in-in ActLoopNT-in 2.8782 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -110.97, 131.36 APE9-dihe-na 113.79, -145.67 APE8-dihe-in -115.43, 125.17 APE8-rot-in 305.08 APE67-dihe-in -54.67, -36.6 -52.93, -49.24 APE12-dist-in 13.2966 APE11-dist-in 12.1561 APE10-dist-in 6.6485 APE9-dist-in 3.5273 None None None XRAY 2.08 0.177 0.218 B 296.0 288.0 4 35 31 4 [[9, 275]] 1.0 6ru7 Homo sapiens CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1.0 262.0 262.0 148 149 150 152 154 38 52 56 125 127 126 128.0 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RU8A P48730 2 294 415.0 ADP:60301 Type1.5_Back Active DFGin 6.4247 15.1564 BLAminus -131.62, -177.15 63.45, 81.35 -98.16, 25.89 286.32, 78.16 -68.14, -23.3 in-in in 7.9265 Saltbr-in 2.8026 HRD-in -87.78, -47.56 70.02, 4.06 in-in-in SNCiii in-in ActLoopNT-in 2.84 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.49, 136.29 APE9-dihe-na 109.45, -154.85 APE8-dihe-in -109.19, 121.34 APE8-rot-in 302.42 APE67-dihe-in -58.68, -38.47 -55.68, -42.0 APE12-dist-in 13.5633 APE11-dist-in 12.2822 APE10-dist-in 6.892 APE9-dist-in 3.5723 None None None XRAY 1.92 0.174 0.211 A 296.0 293.0 0 35 35 0 [[9, 275]] 1.0 6ru8 Homo sapiens CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1.0 262.0 262.0 148 149 150 152 154 38 52 56 125 127 126 128.0 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RU8B P48730 2 294 415.0 ADP:60301 Type1.5_Back Active DFGin 6.5914 15.2638 BLAminus -131.67, -177.68 64.26, 82.5 -98.0, 23.89 285.39, 79.53 -66.54, -22.27 in-in in 7.6625 Saltbr-in 2.7797 HRD-in -88.75, -48.7 67.58, 11.08 in-in-in SNCiii in-in ActLoopNT-in 2.8535 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.47, 142.8 APE9-dihe-na 95.33, -164.73 APE8-dihe-in -102.94, 120.03 APE8-rot-in 301.71 APE67-dihe-in -59.39, -37.33 -59.11, -40.45 APE12-dist-in 12.3078 APE11-dist-in 12.2946 APE10-dist-in 7.2451 APE9-dist-in 3.8917 None None None XRAY 1.92 0.174 0.211 B 296.0 293.0 0 35 35 0 [[9, 275]] 1.0 6ru8 Homo sapiens CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1.0 262.0 262.0 148 149 150 152 154 38 52 56 125 127 126 128.0 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RU8C P48730 2 294 415.0 ADP:60301 Type1.5_Back Active DFGin 6.5578 14.9826 BLAminus -128.29, -179.37 66.68, 80.46 -98.0, 22.92 288.66, 76.31 -64.33, -23.77 in-in in 7.9484 Saltbr-in 2.77 HRD-in -82.99, -49.18 72.75, 4.46 in-in-in SNCiii in-in ActLoopNT-in 2.845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.59, 138.55 APE9-dihe-na 101.61, -152.03 APE8-dihe-in -108.82, 122.86 APE8-rot-in 298.47 APE67-dihe-in -58.74, -36.85 -58.82, -40.4 APE12-dist-in 13.0395 APE11-dist-in 12.4355 APE10-dist-in 6.8683 APE9-dist-in 3.6074 None None None XRAY 1.92 0.174 0.211 C 296.0 287.0 6 35 29 6 [[9, 275]] 1.0 6ru8 Homo sapiens CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1.0 262.0 262.0 148 149 150 152 154 38 52 56 125 127 126 128.0 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_HUMAN 6RU8D P48730 2 294 415.0 ADP:60301 Type1.5_Back Active DFGin 6.534 14.975 BLAminus -126.38, -177.59 65.46, 80.95 -97.97, 21.9 288.13, 75.77 -63.86, -25.32 in-in in 7.9785 Saltbr-in 2.7823 HRD-in -86.34, -48.63 71.97, 3.09 in-in-in SNCiii in-in ActLoopNT-in 2.8104 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.34, 138.88 APE9-dihe-na 102.71, -155.7 APE8-dihe-in -106.76, 124.41 APE8-rot-in 298.22 APE67-dihe-in -58.88, -36.36 -58.72, -41.76 APE12-dist-in 12.7166 APE11-dist-in 12.3523 APE10-dist-in 6.7426 APE9-dist-in 3.5902 None None None XRAY 1.92 0.174 0.211 D 296.0 293.0 0 35 35 0 [[9, 275]] 1.0 6ru8 Homo sapiens CK1_CSNK1D_HUMAN CK1 1.6e-122 413.9 1.0 262.0 262.0 148 149 150 152 154 38 52 56 125 127 126 128.0 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 TTBK1 TTBK1_HUMAN 4BTJA Q5TCY1 21 312 1321.0 ADP:61337 ATPlike Active DFGin 5.5128 12.6986 BLAminus -122.16, 167.53 65.74, 92.18 -107.62, 12.94 309.85, 113.04 -64.35, -28.29 in-in in 7.1274 Saltbr-in 2.7571 HRD-in -79.44, -52.71 73.3, -5.89 in-in-in SNCiii in-in ActLoopNT-in 2.8215 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.78, 143.11 APE9-dihe-na 98.14, -168.76 APE8-dihe-in -84.14, 153.12 APE8-rot-in 322.08 APE67-dihe-in -60.57, -38.77 -75.21, -43.81 APE12-dist-in 11.388 APE11-dist-in 11.4495 APE10-dist-in 5.9453 APE9-dist-in 3.4123 None None None XRAY 2.16 0.179 0.197 A 337.0 292.0 0 34 34 0 [[34, 295]] 1.0 4btj Homo sapiens CK1_TTBK1_HUMAN CK1 5.7e-105 356.4 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
CK1 TTBK2 TTBK2_HUMAN 6VRFA Q6IQ55 9 298 1244.0 ADP:301 ATPlike Active DFGin 5.3543 13.1161 BLAminus -121.29, 164.21 73.75, 82.24 -97.72, 13.38 304.67, 116.94 -64.06, -29.66 in-in in 7.2137 Saltbr-in 2.7506 HRD-in -77.1, -49.95 73.69, -4.56 in-in-in SNCiii in-in ActLoopNT-in 2.8129 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.12, -30.06 APE9-dihe-na -84.65, -146.34 APE8-dihe-in -107.58, 129.44 APE8-rot-in 302.21 APE67-dihe-in -59.13, -37.2 -56.28, -42.66 APE12-dist-in 11.1967 APE11-dist-in 11.3871 APE10-dist-in 5.4802 APE9-dist-in 3.7845 None None None XRAY 1.5 0.175 0.209 A 299.0 287.0 3 34 34 0 [[21, 282]] 1.0 6vrf Homo sapiens CK1_TTBK2_HUMAN CK1 7.7e-104 352.6 1.0 262.0 262.0 162 163 164 166 168 50 64 68 138 140 139 141.0 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2
CK1 TTBK2 TTBK2_HUMAN 6VRFB Q6IQ55 9 298 1244.0 ADP:301 ATPlike Active DFGin 5.4311 12.6951 BLAminus -121.38, 163.64 74.07, 85.5 -102.64, 12.86 306.76, 116.33 -62.94, -32.7 in-in in 7.3455 Saltbr-in 2.8906 HRD-in -78.31, -51.54 73.55, 1.77 in-in-in SNCiii in-in ActLoopNT-in 2.8595 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -109.78, -23.36 APE9-dihe-na -86.88, -149.11 APE8-dihe-in -108.63, 128.02 APE8-rot-in 302.45 APE67-dihe-in -58.2, -36.14 -56.96, -43.7 APE12-dist-in 11.0394 APE11-dist-in 11.2442 APE10-dist-in 5.3369 APE9-dist-in 3.7117 None None None XRAY 1.5 0.175 0.209 B 299.0 287.0 3 34 34 0 [[21, 282]] 1.0 6vrf Homo sapiens CK1_TTBK2_HUMAN CK1 7.7e-104 352.6 1.0 262.0 262.0 162 163 164 166 168 50 64 68 138 140 139 141.0 208 196 191 190 189 188 187 186 185 95 Tau-tubulin kinase 2
CMGC CDK11B CD11B_HUMAN 9I9IK P21127 440 740 795.0 ADP:60801 ATPlike Inactive DFGin 4.7633 14.1457 BLAminus -158.41, -152.11 58.37, 65.02 -86.96, 23.61 281.98, 74.01 -65.45, -34.44 in-in in 9.3484 Saltbr-in 3.0248 HRD-in -87.02, -49.1 60.47, 15.99 in-in-out SNCiio in-out ActLoopNT-in 2.8427 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -140.14, 178.62 APE9-dihe-na 67.65, 142.84 APE8-dihe-in -66.76, 156.24 APE8-rot-out 57.56 APE67-dihe-in -70.3, -10.82 -63.46, -38.5 APE12-dist-in 13.2936 APE11-dist-in 11.3984 APE10-dist-in 6.5133 APE9-dist-in 3.2891 None TPO595 TPO595 EM 3.5 999.0 999.0 K 442.0 268.0 35 28 22 6 [[438, 723]] 1.0 9i9i Homo sapiens CMGC_CDK11B_HUMAN CMGC 5.1e-79 271.6 1.0 301.0 301.0 579 580 581 583 585 467 485 489 559 561 560 562.0 620 607 602 601 600 599 598 597 596 517 Cyclin-dependent kinase 11B
CMGC CDK12 CDK12_HUMAN 4NSTA Q9NYV4 716 1046 1490.0 ADP:1101 ATPlike Inactive DFGin 6.9783 15.1109 BLAminus -127.54, 179.84 60.58, 76.06 -95.3, 23.79 283.73, 86.71 -65.43, -16.77 in-in in 8.9881 Saltbr-in 3.0309 HRD-in -82.28, -56.37 71.8, 9.39 in-in-out SNCiio in-out ActLoopNT-in 2.9558 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -128.59, 153.12 APE9-dihe-na 76.09, 132.29 APE8-dihe-in -60.41, 149.83 APE8-rot-out 85.48 APE67-dihe-in -64.83, -28.79 -60.07, -39.7 APE12-dist-in 13.2466 APE11-dist-in 11.2727 APE10-dist-in 6.9953 APE9-dist-in 3.4606 None TPO893 TPO893 XRAY 2.2 0.198 0.24 A 351.0 323.0 8 29 29 0 [[727, 1020]] 1.0 4nst Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 4NSTC Q9NYV4 717 1045 1490.0 ADP:1101 ATPlike Inactive DFGin 6.9718 15.1681 BLAminus -122.49, -178.57 55.97, 75.42 -92.86, 20.68 283.24, 86.31 -56.98, -20.08 in-in in 8.8631 Saltbr-in 2.9569 HRD-in -69.12, -51.54 66.96, 15.75 in-in-out SNCiio in-out ActLoopNT-in 2.9277 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -129.74, 152.42 APE9-dihe-na 82.09, 126.12 APE8-dihe-in -62.22, 152.62 APE8-rot-out 78.32 APE67-dihe-in -63.16, -30.08 -57.73, -42.25 APE12-dist-in 13.2024 APE11-dist-in 11.2673 APE10-dist-in 6.9416 APE9-dist-in 3.7053 None TPO893 TPO893 XRAY 2.2 0.198 0.24 C 351.0 318.0 11 29 28 1 [[727, 1020]] 1.0 4nst Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK13 CDK13_HUMAN 5EFQA Q14004 695 1025 1512.0 ADP:1101 ATPlike Inactive DFGin 6.755 15.5888 BLAminus -141.88, 177.76 70.28, 48.66 -74.58, 17.49 278.28, 85.63 -61.09, -20.11 in-in in 8.1158 Saltbr-in 2.8139 HRD-in -86.6, -50.11 69.54, 11.28 in-in-out SNCiio in-out ActLoopNT-in 3.1368 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -127.03, -45.46 APE9-dihe-na -90.96, 147.77 APE8-dihe-in -58.82, 149.25 APE8-rot-out 183.76 APE67-dihe-in -63.13, -14.28 -57.08, -47.49 APE12-dist-in 13.2718 APE11-dist-in 11.1213 APE10-dist-in 6.9543 APE9-dist-in 3.3531 None TPO871 TPO871 XRAY 2.0 0.197 0.247 A 347.0 322.0 9 29 29 0 [[705, 998]] 1.0 5efq Homo sapiens CMGC_CDK13_HUMAN CMGC 2.2e-85 292.5 1.0 301.0 301.0 854 855 856 858 860 734 752 756 834 836 835 837.0 896 883 878 877 876 875 874 873 872 792 Cyclin-dependent kinase 13
CMGC CDK13 CDK13_HUMAN 5EFQC Q14004 697 1031 1512.0 ADP:1101 ATPlike Inactive DFGin 6.6712 15.3958 BLAminus -141.53, 176.29 69.41, 51.5 -75.76, 17.57 280.54, 75.34 -60.62, -20.31 in-in in 8.1091 Saltbr-in 2.9445 HRD-in -87.13, -51.3 69.73, 13.1 in-in-out SNCiio in-out ActLoopNT-in 2.9383 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -124.45, -44.56 APE9-dihe-na -90.13, 148.33 APE8-dihe-in -57.19, 149.29 APE8-rot-out 181.48 APE67-dihe-in -63.2, -13.36 -56.43, -47.06 APE12-dist-in 13.4042 APE11-dist-in 11.5865 APE10-dist-in 7.0785 APE9-dist-in 3.3455 None TPO871 TPO871 XRAY 2.0 0.197 0.247 C 347.0 326.0 9 29 29 0 [[705, 998]] 1.0 5efq Homo sapiens CMGC_CDK13_HUMAN CMGC 2.2e-85 292.5 1.0 301.0 301.0 854 855 856 858 860 734 752 756 834 836 835 837.0 896 883 878 877 876 875 874 873 872 792 Cyclin-dependent kinase 13
CMGC CDK2 CDK2_HUMAN 4I3ZA P24941 1 296 298.0 ADP:60301 ATPlike Active DFGin 6.4079 15.1483 BLAminus -137.57, -176.06 52.96, 75.44 -91.33, 19.91 280.72, 70.75 -64.88, -19.38 in-in in 8.599 Saltbr-in 2.9877 HRD-in -80.76, -55.87 72.55, 4.85 in-in-in SNCiii in-in ActLoopNT-in 2.9014 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.11, -96.25 APE9-dihe-na -51.92, 142.27 APE8-dihe-in -55.11, 135.08 APE8-rot-in 307.48 APE67-dihe-in -54.58, -26.51 -40.4, -56.95 APE12-dist-in 13.0643 APE11-dist-in 10.5846 APE10-dist-in 6.8229 APE9-dist-in 3.3051 None TPO160 TPO160 XRAY 2.05 0.199 0.228 A 296.0 296.0 0 28 28 0 [[4, 286]] 1.0 4i3z Homo sapiens CMGC_CDK2_HUMAN CMGC 6.2e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4I3ZC P24941 1 296 298.0 ADP:60301 ATPlike Active DFGin 6.3666 15.146 BLAminus -139.14, -175.0 51.64, 79.19 -95.11, 18.85 278.6, 70.91 -64.63, -17.11 in-in in 8.6529 Saltbr-in 2.9791 HRD-in -79.85, -55.96 72.81, 4.84 in-in-in SNCiii in-in ActLoopNT-in 2.9165 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.52, -96.18 APE9-dihe-na -52.61, 142.23 APE8-dihe-in -53.61, 133.4 APE8-rot-in 308.84 APE67-dihe-in -53.33, -28.57 -37.02, -58.54 APE12-dist-in 13.0807 APE11-dist-in 10.6179 APE10-dist-in 6.8613 APE9-dist-in 3.3051 None TPO160 TPO160 XRAY 2.05 0.199 0.228 C 296.0 296.0 0 28 28 0 [[4, 286]] 1.0 4i3z Homo sapiens CMGC_CDK2_HUMAN CMGC 6.2e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3QHRA P24941 1 296 298.0 ADP:60297 ATPlike Active DFGin 6.5567 15.1071 BLAminus -129.61, -176.27 55.27, 75.32 -97.07, 17.79 280.43, 72.68 -60.79, -23.59 in-in in 8.696 Saltbr-in 2.8804 HRD-in -78.46, -57.59 71.9, 8.99 in-in-in SNCiii in-in ActLoopNT-in 2.8774 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.99, 139.5 APE9-dihe-na 85.76, 129.74 APE8-dihe-in -56.31, 140.07 APE8-rot-in 302.24 APE67-dihe-in -65.07, -20.31 -41.24, -52.35 APE12-dist-in 12.989 APE11-dist-in 10.1708 APE10-dist-in 7.1114 APE9-dist-in 3.3412 None TPO160 TPO160 XRAY 2.17 0.18 0.21 A 298.0 296.0 0 28 28 0 [[4, 286]] 1.0 3qhr Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3QHRC P24941 1 296 298.0 ADP:60297 ATPlike Active DFGin 6.5652 15.1213 BLAminus -133.25, -174.75 53.96, 72.74 -93.36, 15.91 281.14, 71.23 -60.56, -21.49 in-in in 8.6995 Saltbr-in 2.8684 HRD-in -78.47, -57.15 72.13, 9.85 in-in-in SNCiii in-in ActLoopNT-in 2.8757 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.81, 147.52 APE9-dihe-na 81.05, 137.24 APE8-dihe-in -64.2, 137.48 APE8-rot-in 304.68 APE67-dihe-in -62.37, -22.27 -38.55, -53.11 APE12-dist-in 12.9853 APE11-dist-in 10.2322 APE10-dist-in 6.9899 APE9-dist-in 3.293 None TPO160 TPO160 XRAY 2.17 0.18 0.21 C 298.0 296.0 0 28 28 0 [[4, 286]] 1.0 3qhr Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3QHWA P24941 1 296 298.0 ADP:60297 ATPlike Active DFGin 6.4347 15.0131 BLAminus -134.08, -174.07 54.44, 75.18 -91.31, 13.19 281.29, 72.4 -60.66, -23.16 in-in in 8.6396 Saltbr-in 2.9345 HRD-in -72.46, -52.11 70.84, 4.06 in-in-in SNCiii in-in ActLoopNT-in 2.9031 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -117.61, -86.88 APE9-dihe-na -62.59, 147.47 APE8-dihe-in -61.56, 138.19 APE8-rot-in 297.56 APE67-dihe-in -60.69, -27.39 -44.54, -49.89 APE12-dist-in 12.9955 APE11-dist-in 10.2303 APE10-dist-in 6.7823 APE9-dist-in 3.3592 None TPO160 TPO160 XRAY 1.91 0.189 0.219 A 298.0 296.0 0 28 28 0 [[4, 286]] 1.0 3qhw Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 3QHWC P24941 1 296 298.0 ADP:60297 ATPlike Active DFGin 6.4533 15.0832 BLAminus -135.33, -175.53 57.5, 71.73 -89.85, 9.67 280.79, 72.12 -55.86, -26.79 in-in in 8.6175 Saltbr-in 2.8956 HRD-in -73.76, -53.15 71.96, 3.16 in-in-in SNCiii in-in ActLoopNT-in 2.8982 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.86, -80.28 APE9-dihe-na -65.52, 146.91 APE8-dihe-in -61.19, 139.69 APE8-rot-in 298.69 APE67-dihe-in -57.2, -28.53 -47.15, -50.79 APE12-dist-in 12.997 APE11-dist-in 10.1334 APE10-dist-in 6.7222 APE9-dist-in 3.3609 None TPO160 TPO160 XRAY 1.91 0.189 0.219 C 298.0 296.0 0 28 28 0 [[4, 286]] 1.0 3qhw Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4II5A P24941 1 296 298.0 ADP:60301 ATPlike Active DFGin 6.2945 15.2747 BLAminus -136.76, -174.67 48.15, 75.69 -89.27, 15.07 281.74, 67.11 -54.49, -30.0 in-in in 8.6748 Saltbr-in 2.898 HRD-in -77.95, -58.94 72.46, 5.93 in-in-in SNCiii in-in ActLoopNT-in 2.856 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.58, 147.66 APE9-dihe-na 74.72, 130.64 APE8-dihe-in -63.5, 139.49 APE8-rot-in 303.89 APE67-dihe-in -59.35, -27.46 -47.25, -50.52 APE12-dist-in 13.1273 APE11-dist-in 10.3722 APE10-dist-in 7.0336 APE9-dist-in 3.3441 None TPO160 TPO160 XRAY 2.15 0.2 0.226 A 298.0 296.0 0 28 28 0 [[4, 286]] 1.0 4ii5 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4II5C P24941 1 296 298.0 ADP:60301 ATPlike Active DFGin 6.2891 15.2882 BLAminus -134.89, -171.63 44.93, 79.89 -96.21, 16.02 275.02, 74.95 -60.79, -24.87 in-in in 8.6656 Saltbr-in 2.9402 HRD-in -77.09, -52.7 69.17, 3.7 in-in-in SNCiii in-in ActLoopNT-in 2.8581 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.65, 138.88 APE9-dihe-na 85.57, 133.69 APE8-dihe-in -65.51, 139.86 APE8-rot-in 305.2 APE67-dihe-in -60.76, -27.54 -47.35, -49.81 APE12-dist-in 13.1414 APE11-dist-in 10.3821 APE10-dist-in 7.0612 APE9-dist-in 3.3866 None TPO160 TPO160 XRAY 2.15 0.2 0.226 C 298.0 296.0 0 28 28 0 [[4, 286]] 1.0 4ii5 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9I9JK P24941 6 284 298.0 ADP:60301 ATPlike Inactive DFGin 7.5021 16.7795 BLAminus -158.16, 171.41 58.55, 63.81 -89.46, 61.19 266.29, 72.56 161.2, 999.0 in-out in 9.1187 Saltbr-out 5.2547 HRD-in -89.48, -59.44 66.59, -3.23 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -47.83 APE8-dihe-out -98.29, 31.77 APE8-rot-out 77.96 APE67-dihe-in -64.85, -20.6 -65.62, -27.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.1296 None None None EM 3.1 999.0 999.0 K 301.0 246.0 37 28 12 16 [[4, 286]] 1.0 9i9j Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9I9KK P24941 2 292 298.0 ADP:60301 ATPlike Inactive DFGin 7.3023 15.9065 BLAminus -142.34, -176.15 60.61, 65.17 -90.86, 48.23 288.67, 80.56 -88.9, -30.85 out-out out 10.4864 Saltbr-out 5.6503 HRD-in -65.4, -52.43 72.61, -10.3 out-in-out SNCoio in-out ActLoopNT-in 2.5583 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -73.37, 146.13 APE9-dihe-na -115.04, 137.49 APE8-dihe-in -60.96, 144.59 APE8-rot-out 184.92 APE67-dihe-in -75.1, -11.28 -107.26, -12.43 APE12-dist-in 12.0105 APE11-dist-in 8.1866 APE10-dist-out 12.0491 APE9-dist-out 7.5485 None None None EM 2.4 999.0 999.0 K 301.0 276.0 15 28 28 0 [[4, 286]] 1.0 9i9k Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK7 CDK7_HUMAN 9I9IJ P50613 12 310 346.0 ADP:60401 ATPlike Inactive DFGin 6.598 15.1475 BLAminus -154.26, -174.63 55.49, 63.23 -84.52, 21.08 280.13, 83.68 -62.16, -39.37 in-out in 8.6205 Saltbr-out 4.7244 HRD-in -68.87, -48.72 60.83, 9.92 out-in-out SNCoio in-out ActLoopNT-in 2.7723 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -114.8, -59.65 APE9-dihe-na -71.54, 157.02 APE8-dihe-in -67.36, 161.57 APE8-rot-out 77.35 APE67-dihe-in -72.1, -35.43 -63.15, -31.03 APE12-dist-in 12.4211 APE11-dist-in 11.2397 APE10-dist-in 6.1345 APE9-dist-in 3.7163 None None None EM 3.5 999.0 999.0 J 391.0 294.0 5 28 28 0 [[12, 295]] 1.0 9i9i Homo sapiens CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 9I9JJ P50613 11 310 346.0 ADP:60401 ATPlike Inactive DFGin 7.0461 15.5114 BLAminus -142.62, -171.5 55.13, 63.56 -86.1, 20.41 278.63, 86.43 -73.48, -14.71 in-in in 8.4748 Saltbr-in 3.2618 HRD-in -63.57, -47.3 66.21, -0.54 in-in-out SNCiio in-out ActLoopNT-in 2.8761 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -125.41, 160.15 APE9-dihe-na -72.91, 167.58 APE8-dihe-in -60.97, 159.12 APE8-rot-out 182.98 APE67-dihe-in -64.29, -19.96 -63.65, -26.45 APE12-dist-in 11.2078 APE11-dist-out 5.3409 APE10-dist-out 9.2018 APE9-dist-in 4.0331 None None None EM 3.1 999.0 999.0 J 391.0 290.0 10 28 23 5 [[12, 295]] 1.0 9i9j Homo sapiens CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 9I9KJ P50613 10 310 346.0 ADP:60401 ATPlike Inactive DFGin 6.8665 15.1598 BLAminus -144.56, -175.34 58.29, 64.88 -85.43, 20.68 280.65, 74.04 -68.51, -15.78 in-in in 8.4034 Saltbr-in 3.4231 HRD-in -66.35, -48.78 67.04, 4.57 in-in-out SNCiio in-out ActLoopNT-in 2.7011 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -135.97, 162.75 APE9-dihe-na -69.89, 166.52 APE8-dihe-in -58.19, 147.77 APE8-rot-out 190.67 APE67-dihe-in -62.09, -25.1 -66.28, -24.83 APE12-dist-in 11.5433 APE11-dist-out 5.9477 APE10-dist-out 9.1593 APE9-dist-in 3.8908 None None None EM 2.4 999.0 999.0 J 391.0 301.0 0 28 28 0 [[12, 295]] 1.0 9i9k Homo sapiens CMGC_CDK7_HUMAN CMGC 2.4e-78 271.1 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CSNK2A1 CSK21_HUMAN 6Z19B P68400 2 329 391.0 ADP:401 ATPlike Active DFGin 7.3985 16.1019 BLAminus -106.47, -175.56 60.6, 79.25 -100.03, 20.37 297.28, 82.12 -73.41, -21.13 in-in in 8.7167 Saltbr-in 2.7999 HRD-in -71.6, -55.48 75.88, 3.64 in-in-in SNCiii in-in ActLoopNT-in 2.9276 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.14, 153.25 APE9-dihe-na 78.4, 166.67 APE8-dihe-in -74.52, 152.52 APE8-rot-in 285.35 APE67-dihe-in -64.18, -23.8 -57.77, -45.77 APE12-dist-in 12.9676 APE11-dist-in 10.9929 APE10-dist-in 6.495 APE9-dist-in 3.5915 None None None XRAY 1.47 0.19 0.221 B 328.0 328.0 0 27 27 0 [[39, 324]] 1.0 6z19 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.2e-69 240.7 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OQUB P68400 4 327 391.0 ADP:401 ATPlike Active DFGin 7.3237 16.3919 BLAminus -107.74, -171.87 52.49, 78.62 -101.36, 19.11 291.9, 83.91 -71.23, -12.83 in-in in 9.4959 Saltbr-in 2.9014 HRD-in -65.86, -46.78 65.2, 13.55 in-in-in SNCiii in-in ActLoopNT-in 2.8952 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.87, 169.85 APE9-dihe-na 66.11, 165.52 APE8-dihe-in -87.57, 142.09 APE8-rot-in 294.71 APE67-dihe-in -65.28, -26.45 -36.1, -50.26 APE12-dist-in 12.5919 APE11-dist-in 10.4195 APE10-dist-in 6.0893 APE9-dist-in 3.1538 R21S None None XRAY 2.324 0.221 0.244 B 352.0 324.0 0 27 27 0 [[39, 324]] 1.0 5oqu Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5ORKB P68400 4 326 391.0 ADP:401 ATPlike Active DFGin 7.365 16.4878 BLAminus -111.04, -174.54 54.53, 77.94 -96.47, 19.83 296.01, 82.36 -66.2, -23.13 in-in in 9.5516 Saltbr-in 3.0409 HRD-in -70.69, -49.04 67.52, 16.07 in-in-in SNCiii in-in ActLoopNT-in 2.8623 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.56, 172.18 APE9-dihe-na 65.73, 167.16 APE8-dihe-in -89.89, 143.95 APE8-rot-in 298.57 APE67-dihe-in -64.35, -23.63 -31.56, -56.57 APE12-dist-in 12.6145 APE11-dist-in 10.418 APE10-dist-in 6.0623 APE9-dist-in 3.1494 R21S None None XRAY 2.143 0.217 0.243 B 352.0 323.0 0 27 27 0 [[39, 324]] 1.0 5ork Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7QUXA P68400 2 329 391.0 ADP:60401 ATPlike Active DFGin 7.5848 16.1937 BLAminus -111.52, -172.63 60.82, 80.19 -104.84, 23.49 298.85, 85.23 -72.93, -20.15 in-in in 8.9584 Saltbr-in 2.8383 HRD-in -72.19, -52.24 72.27, 9.35 in-in-in SNCiii in-in ActLoopNT-in 2.8457 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.66, 178.74 APE9-dihe-na 61.29, -172.26 APE8-dihe-in -113.53, 144.19 APE8-rot-in 304.18 APE67-dihe-in -65.08, -18.11 -36.49, -57.4 APE12-dist-in 12.7233 APE11-dist-in 10.5788 APE10-dist-in 6.2143 APE9-dist-in 2.896 None SEP2 SEP2 XRAY 1.48 0.181 0.204 A 352.0 328.0 0 27 27 0 [[39, 324]] 1.0 7qux Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6YZHA P68400 3 329 391.0 ADP:60403 ATPlike Active DFGin 7.3857 16.3097 BLAminus -108.01, -176.38 61.1, 79.34 -99.78, 17.26 297.37, 82.49 -78.41, -8.16 in-in in 9.1307 Saltbr-in 2.8294 HRD-in -74.51, -47.7 69.86, 14.14 in-in-in SNCiii in-in ActLoopNT-in 2.8828 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.83, 175.48 APE9-dihe-na 62.95, -168.81 APE8-dihe-in -126.52, 135.38 APE8-rot-in 299.93 APE67-dihe-in -66.68, -18.66 -34.87, -54.46 APE12-dist-in 12.682 APE11-dist-in 10.343 APE10-dist-in 6.2268 APE9-dist-in 3.0838 None None None XRAY 1.19 0.173 0.19 A 398.0 327.0 0 27 27 0 [[39, 324]] 1.0 6yzh Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 2.4e-69 239.8 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6YPNB P68400 2 327 391.0 ADP:401,ADP:403 ATPlike,Allosteric Active DFGin 7.4975 16.1393 BLAminus -109.68, -177.56 60.98, 76.07 -97.07, 19.64 297.88, 85.05 -61.67, -35.53 in-in in 8.8083 Saltbr-in 3.0148 HRD-in -64.91, -46.49 66.87, 14.57 in-in-in SNCiii in-in ActLoopNT-in 2.8651 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.57, 178.38 APE9-dihe-na 58.61, -169.26 APE8-dihe-in -123.99, 137.29 APE8-rot-in 306.99 APE67-dihe-in -67.45, -16.12 -20.54, -62.85 APE12-dist-in 12.7883 APE11-dist-in 10.4586 APE10-dist-in 6.2695 APE9-dist-in 3.1801 None None None XRAY 1.58 0.207 0.247 B 329.0 326.0 0 27 27 0 [[39, 324]] 1.0 6ypn Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.2e-69 240.7 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5CVHA P68400 2 328 391.0 ADP:401,IHP:402 ATPlike,Allosteric Active DFGin 7.3513 16.2646 BLAminus -108.96, -174.88 56.89, 75.34 -94.42, 15.0 293.73, 80.57 -64.71, -19.68 in-in in 9.4185 Saltbr-in 2.8687 HRD-in -72.87, -47.99 69.09, 10.68 in-in-in SNCiii in-in ActLoopNT-in 2.9006 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.61, 174.2 APE9-dihe-na 62.86, 175.04 APE8-dihe-in -103.43, 141.93 APE8-rot-in 298.78 APE67-dihe-in -64.49, -19.58 -33.62, -57.11 APE12-dist-in 12.7395 APE11-dist-in 10.5441 APE10-dist-in 6.0999 APE9-dist-in 3.1153 R21S None None XRAY 1.848 0.204 0.22 A 352.0 327.0 0 27 27 0 [[39, 324]] 1.0 5cvh Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5CVHB P68400 4 327 391.0 ADP:401,IHP:402 ATPlike,Allosteric Active DFGin 7.3336 16.5055 BLAminus -108.95, -175.21 55.5, 76.34 -94.47, 15.14 293.04, 80.42 -64.89, -20.52 in-in in 9.6517 Saltbr-in 2.9197 HRD-in -71.77, -46.42 66.39, 11.3 in-in-in SNCiii in-in ActLoopNT-in 2.8914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.23, 173.23 APE9-dihe-na 63.78, 174.17 APE8-dihe-in -100.91, 142.72 APE8-rot-in 301.86 APE67-dihe-in -62.55, -20.09 -31.2, -58.6 APE12-dist-in 12.6313 APE11-dist-in 10.4259 APE10-dist-in 6.0374 APE9-dist-in 3.1186 R21S None None XRAY 1.848 0.204 0.22 B 352.0 324.0 0 27 27 0 [[39, 324]] 1.0 5cvh Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5MP8A P68400 3 327 391.0 ADP:404,RKN:406 ATPlike,Allosteric Active DFGin 7.3305 16.1632 BLAminus -110.84, -174.11 53.51, 76.37 -93.65, 17.26 296.86, 81.68 -66.57, -22.0 in-in in 9.3173 Saltbr-in 2.8626 HRD-in -67.91, -49.16 67.59, 13.12 in-in-in SNCiii in-in ActLoopNT-in 2.9047 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.47, 167.73 APE9-dihe-na 65.86, 165.2 APE8-dihe-in -87.13, 142.99 APE8-rot-in 303.44 APE67-dihe-in -64.04, -21.15 -31.41, -58.51 APE12-dist-in 12.6867 APE11-dist-in 10.4641 APE10-dist-in 6.121 APE9-dist-in 3.1624 R21S None None XRAY 1.92 0.213 0.224 A 352.0 325.0 0 27 27 0 [[39, 324]] 1.0 5mp8 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5MP8B P68400 3 325 391.0 ADP:402,RKN:405 ATPlike,Allosteric Active DFGin 7.3235 16.3489 BLAminus -110.28, -174.91 53.58, 76.31 -93.48, 18.26 296.68, 81.06 -66.02, -21.8 in-in in 9.4483 Saltbr-in 2.9073 HRD-in -64.03, -48.98 66.77, 13.43 in-in-in SNCiii in-in ActLoopNT-in 2.9117 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.49, 167.73 APE9-dihe-na 66.13, 163.08 APE8-dihe-in -85.62, 144.24 APE8-rot-in 302.43 APE67-dihe-in -63.28, -21.33 -32.96, -58.46 APE12-dist-in 12.6455 APE11-dist-in 10.3733 APE10-dist-in 6.1129 APE9-dist-in 3.1511 R21S None None XRAY 1.92 0.213 0.224 B 352.0 323.0 0 27 27 0 [[39, 324]] 1.0 5mp8 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5ORJB P68400 4 327 391.0 ADP:403,A4Q:404 ATPlike,Allosteric Active DFGin 7.2646 16.3413 BLAminus -111.15, -176.6 55.76, 79.82 -97.57, 16.74 293.2, 81.02 -66.75, -20.87 in-in in 9.4788 Saltbr-in 3.0155 HRD-in -67.24, -46.68 66.46, 8.84 in-in-in SNCiii in-in ActLoopNT-in 2.9685 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.61, 174.53 APE9-dihe-na 65.24, 168.77 APE8-dihe-in -97.72, 138.95 APE8-rot-in 305.57 APE67-dihe-in -64.92, -22.35 -27.33, -57.79 APE12-dist-in 12.6095 APE11-dist-in 10.4061 APE10-dist-in 6.0013 APE9-dist-in 3.1263 R21S None None XRAY 1.99 0.201 0.221 B 352.0 324.0 0 27 27 0 [[39, 324]] 1.0 5orj Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5ORKA P68400 4 327 391.0 ADP:401,A4T:404 ATPlike,Allosteric Active DFGin 7.3925 16.3137 BLAminus -113.19, -173.71 54.76, 77.71 -95.81, 17.23 296.74, 84.21 -67.53, -20.95 in-in in 9.3575 Saltbr-in 3.0228 HRD-in -73.92, -50.16 69.3, 15.04 in-in-in SNCiii in-in ActLoopNT-in 2.8727 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.23, 173.79 APE9-dihe-na 63.16, 167.87 APE8-dihe-in -90.44, 143.76 APE8-rot-in 298.85 APE67-dihe-in -64.65, -24.13 -31.17, -56.13 APE12-dist-in 12.6312 APE11-dist-in 10.4313 APE10-dist-in 6.0622 APE9-dist-in 3.1643 R21S None None XRAY 2.143 0.217 0.243 A 352.0 324.0 0 27 27 0 [[39, 324]] 1.0 5ork Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZYKA P68400 3 329 391.0 ADP:401,KEC:402 ATPlike,Allosteric Active DFGin 7.269 16.0622 BLAminus -118.69, -179.59 61.79, 73.49 -91.41, 13.81 296.07, 81.24 -64.93, -20.57 in-in in 9.1757 Saltbr-in 3.0874 HRD-in -73.86, -46.68 67.1, 11.06 in-in-in SNCiii in-in ActLoopNT-in 2.8397 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.3, 165.81 APE9-dihe-na 64.18, 165.94 APE8-dihe-in -85.42, 147.47 APE8-rot-in 296.52 APE67-dihe-in -73.89, -14.69 -37.67, -50.01 APE12-dist-in 12.7414 APE11-dist-in 10.3817 APE10-dist-in 6.2844 APE9-dist-in 3.2575 R21S,K74A,K75A,K76A None None XRAY 1.31 0.191 0.206 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 7zyk Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5MPJA P68400 3 328 391.0 ADP:401,IHP:402,J2P:403 ATPlike,Allosteric,Allosteric Active DFGin 7.3468 16.241 BLAminus -108.98, -172.35 51.93, 78.25 -97.48, 15.87 295.39, 81.91 -64.67, -20.13 in-in in 9.407 Saltbr-in 3.123 HRD-in -65.25, -50.84 66.66, 13.27 in-in-in SNCiii in-in ActLoopNT-in 2.9405 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.52, 170.99 APE9-dihe-na 63.12, 171.83 APE8-dihe-in -95.06, 139.24 APE8-rot-in 294.97 APE67-dihe-in -59.9, -28.22 -27.45, -59.89 APE12-dist-in 12.7865 APE11-dist-in 10.5397 APE10-dist-in 6.1033 APE9-dist-in 3.1634 R21S None None XRAY 2.14 0.214 0.241 A 352.0 326.0 0 27 27 0 [[39, 324]] 1.0 5mpj Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OQUA P68400 4 327 391.0 ADP:401,A4B:402,IHP:408 ATPlike,Allosteric,Allosteric Active DFGin 7.4477 16.2501 BLAminus -109.0, -171.89 53.56, 75.1 -98.21, 18.1 294.2, 83.27 -72.09, -15.18 in-in in 9.3691 Saltbr-in 2.8268 HRD-in -72.33, -46.9 69.21, 10.87 in-in-in SNCiii in-in ActLoopNT-in 2.9655 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.38, 169.57 APE9-dihe-na 63.73, 165.9 APE8-dihe-in -87.91, 142.9 APE8-rot-in 295.65 APE67-dihe-in -63.9, -27.03 -35.31, -52.27 APE12-dist-in 12.6696 APE11-dist-in 10.4664 APE10-dist-in 6.1543 APE9-dist-in 3.1404 R21S None None XRAY 2.324 0.221 0.244 A 352.0 324.0 0 27 27 0 [[39, 324]] 1.0 5oqu Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OSLA P68400 2 329 391.0 ADP:403,A9K:406,A9K:407 ATPlike,Allosteric,Allosteric Active DFGin 7.4581 16.1961 BLAminus -110.64, -174.68 55.81, 76.64 -96.18, 20.64 295.73, 82.92 -66.89, -23.66 in-in in 9.1209 Saltbr-in 2.8789 HRD-in -70.65, -51.51 73.54, 4.25 in-in-in SNCiii in-in ActLoopNT-in 2.987 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.81, 161.35 APE9-dihe-na 64.27, 160.37 APE8-dihe-in -77.24, 145.71 APE8-rot-in 308.44 APE67-dihe-in -67.76, -20.24 -38.72, -52.2 APE12-dist-in 12.8335 APE11-dist-in 10.614 APE10-dist-in 6.3337 APE9-dist-in 3.627 R21S,K74A,K75A,K76A None None XRAY 1.95 0.165 0.211 A 342.0 328.0 0 27 27 0 [[39, 324]] 1.0 5osl Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 9.4e-69 237.9 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5MOEB P68400 4 326 391.0 ADP:401,IHP:404,OQC:408,OQC:409 ATPlike,Allosteric,Allosteric,Allosteric Active DFGin 7.3649 16.3363 BLAminus -112.77, -173.88 54.48, 74.44 -91.99, 16.05 295.46, 80.22 -64.57, -20.81 in-in in 9.4786 Saltbr-in 2.889 HRD-in -71.14, -46.59 66.38, 12.51 in-in-in SNCiii in-in ActLoopNT-in 2.8725 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.91, 173.34 APE9-dihe-na 63.06, 172.04 APE8-dihe-in -102.52, 138.64 APE8-rot-in 304.11 APE67-dihe-in -65.23, -21.43 -26.29, -58.65 APE12-dist-in 12.6043 APE11-dist-in 10.4054 APE10-dist-in 6.0634 APE9-dist-in 3.1151 R21S None None XRAY 1.89 0.197 0.208 B 352.0 323.0 0 27 27 0 [[39, 324]] 1.0 5moe Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5ORJA P68400 3 327 391.0 ADP:404,A4Q:405,A4Q:406,IHP:407 ATPlike,Allosteric,Allosteric,Allosteric Active DFGin 7.3152 16.1818 BLAminus -113.3, -173.8 55.0, 78.92 -98.71, 18.23 293.93, 79.8 -66.17, -22.25 in-in in 9.3296 Saltbr-in 3.0231 HRD-in -76.84, -43.62 65.1, 10.62 in-in-in SNCiii in-in ActLoopNT-in 2.9091 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.05, 173.87 APE9-dihe-na 60.43, 175.34 APE8-dihe-in -100.91, 141.29 APE8-rot-in 294.98 APE67-dihe-in -64.65, -20.18 -32.63, -57.01 APE12-dist-in 12.6896 APE11-dist-in 10.5231 APE10-dist-in 6.1349 APE9-dist-in 3.1729 R21S None None XRAY 1.99 0.201 0.221 A 352.0 325.0 0 27 27 0 [[39, 324]] 1.0 5orj Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5MOEA P68400 3 327 391.0 ADP:401,IHP:404,OQC:409,OQC:410,OQC:411 ATPlike,Allosteric,Allosteric,Allosteric,Allosteric Active DFGin 7.3743 16.1839 BLAminus -113.03, -172.32 55.01, 74.02 -92.87, 17.49 295.96, 80.42 -65.27, -21.9 in-in in 9.335 Saltbr-in 2.8232 HRD-in -73.11, -47.25 66.93, 11.97 in-in-in SNCiii in-in ActLoopNT-in 2.8891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.86, 173.34 APE9-dihe-na 63.53, 173.35 APE8-dihe-in -101.83, 138.62 APE8-rot-in 302.36 APE67-dihe-in -64.87, -18.25 -29.63, -58.0 APE12-dist-in 12.6777 APE11-dist-in 10.5011 APE10-dist-in 6.1038 APE9-dist-in 3.1115 R21S None None XRAY 1.89 0.197 0.208 A 352.0 325.0 0 27 27 0 [[39, 324]] 1.0 5moe Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZY0A P68400 3 329 391.0 KC0:401,ADP:402 Allosteric,ATPlike Active DFGin 7.4453 16.2362 BLAminus -121.24, -177.58 61.58, 73.29 -95.57, 19.56 295.71, 82.78 -68.2, -19.93 in-in in 9.1425 Saltbr-in 2.8354 HRD-in -73.32, -51.17 71.86, 9.65 in-in-in SNCiii in-in ActLoopNT-in 2.8954 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.67, 170.29 APE9-dihe-na 67.14, 162.49 APE8-dihe-in -85.98, 150.23 APE8-rot-in 297.56 APE67-dihe-in -70.24, -15.73 -44.75, -49.95 APE12-dist-in 12.6182 APE11-dist-in 10.2666 APE10-dist-in 6.1422 APE9-dist-in 3.1596 R21S,K74A,K75A,K76A None None XRAY 1.44 0.2 0.214 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 7zy0 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 8AE7A P68400 3 329 391.0 LVU:403,ADP:404 Allosteric,ATPlike Active DFGin 7.2701 16.1202 BLAminus -116.86, -174.55 56.89, 71.78 -90.66, 15.89 296.23, 82.47 -66.69, -21.09 in-in in 9.1657 Saltbr-in 2.9021 HRD-in -74.15, -48.16 69.73, 11.22 in-in-in SNCiii in-in ActLoopNT-in 2.8441 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.63, 168.68 APE9-dihe-na 61.6, 159.52 APE8-dihe-in -83.61, 146.39 APE8-rot-in 290.46 APE67-dihe-in -69.61, -14.41 -36.06, -54.13 APE12-dist-in 12.6687 APE11-dist-in 10.213 APE10-dist-in 6.181 APE9-dist-in 3.2278 R21S,K74A,K75A,K76A None None XRAY 1.28 0.205 0.232 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 8ae7 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7I8IA P68400 3 329 391.0 A1BZ5:402,ADP:403 Type1,Allosteric Active DFGin 7.509 16.1976 BLAminus -114.79, -179.23 51.74, 77.25 -89.04, 19.22 296.06, 83.25 -67.78, -21.4 in-in in 9.214 Saltbr-in 2.7466 HRD-in -73.97, -49.71 72.98, 8.01 in-in-in SNCiii in-in ActLoopNT-in 2.871 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.34, 166.93 APE9-dihe-na 64.1, 155.12 APE8-dihe-in -82.08, 146.04 APE8-rot-in 277.65 APE67-dihe-in -69.99, -12.65 -33.63, -55.35 APE12-dist-in 12.8488 APE11-dist-in 10.5019 APE10-dist-in 6.3456 APE9-dist-in 3.2901 R21S,K74A,K75A,K76A None None XRAY 1.47 0.182 0.208 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 7i8i Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7I8LA P68400 3 329 391.0 A1B0I:401,ADP:402 Type1,Allosteric Active DFGin 7.4692 16.1742 BLAminus -114.83, -178.51 53.33, 76.08 -89.6, 18.77 294.58, 80.79 -67.15, -22.69 in-in in 9.2225 Saltbr-in 2.7653 HRD-in -77.98, -46.47 70.26, 9.7 in-in-in SNCiii in-in ActLoopNT-in 2.8844 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.24, 169.88 APE9-dihe-na 62.42, 155.06 APE8-dihe-in -81.97, 147.51 APE8-rot-in 279.2 APE67-dihe-in -72.11, -11.91 -35.53, -53.62 APE12-dist-in 12.8613 APE11-dist-in 10.5177 APE10-dist-in 6.3932 APE9-dist-in 3.2941 R21S,K74A,K75A,K76A None None XRAY 1.48 0.184 0.203 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 7i8l Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7I8QA P68400 3 329 391.0 A1BZU:402,ADP:403 Type1,Allosteric Active DFGin 7.4792 16.1471 BLAminus -114.23, -175.31 54.63, 75.78 -91.18, 24.13 295.07, 81.04 -69.52, -25.94 in-in in 8.9728 Saltbr-in 2.7604 HRD-in -73.41, -51.65 72.74, 4.84 in-in-in SNCiii in-in ActLoopNT-in 2.8878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.8, 171.34 APE9-dihe-na 61.22, 163.5 APE8-dihe-in -95.71, 145.02 APE8-rot-in 296.25 APE67-dihe-in -71.38, -16.61 -34.03, -51.24 APE12-dist-in 12.8091 APE11-dist-in 10.4409 APE10-dist-in 6.2561 APE9-dist-in 3.114 R21S,K74A,K75A,K76A None None XRAY 1.66 0.191 0.22 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 7i8q Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC GSK3B GSK3B_HUMAN 4NM5A P49841 24 383 420.0 ADP:60401 ATPlike Active DFGin 6.5502 14.0064 BLAminus -136.16, -177.73 61.88, 88.47 -108.64, 28.76 287.87, 80.78 -73.66, -15.44 in-in in 8.6187 Saltbr-in 2.6732 HRD-in -65.83, -43.73 64.82, 15.23 in-in-in SNCiii in-in ActLoopNT-in 2.8386 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.92, 173.97 APE9-dihe-na 66.26, 147.02 APE8-dihe-in -77.1, 152.8 APE8-rot-in 293.28 APE67-dihe-inflip 82.03, -25.76 -52.23, 150.7 APE12-dist-in 13.2793 APE11-dist-in 11.5989 APE10-dist-in 6.9485 APE9-dist-in 3.2377 None None None XRAY 2.3 0.185 0.232 A 377.0 360.0 0 27 27 0 [[56, 340]] 1.0 4nm5 Homo sapiens CMGC_GSK3B_HUMAN CMGC 2.3e-70 243.3 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 4NM7A P49841 25 383 420.0 ADP:60401 ATPlike Active DFGin 6.5153 13.993 BLAminus -137.35, -178.06 62.82, 88.6 -107.3, 24.56 288.41, 80.2 -69.84, -12.63 in-in in 8.8181 Saltbr-in 2.743 HRD-in -66.5, -46.64 67.84, 11.79 in-in-in SNCiii in-in ActLoopNT-in 2.8287 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.92, 172.54 APE9-dihe-na 68.99, 153.43 APE8-dihe-in -86.9, 151.79 APE8-rot-in 300.04 APE67-dihe-inflip 84.67, -25.93 -50.38, 146.2 APE12-dist-in 13.3553 APE11-dist-in 11.6779 APE10-dist-in 6.9055 APE9-dist-in 3.2102 None None None XRAY 2.3 0.185 0.234 A 377.0 354.0 2 27 27 0 [[56, 340]] 1.0 4nm7 Homo sapiens CMGC_GSK3B_HUMAN CMGC 2.3e-70 243.3 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 4NM0A P49841 26 383 420.0 ADP:60408 ATPlike Inactive DFGin 6.641 14.2129 BLAminus -133.4, -174.33 56.9, 85.51 -105.72, 27.83 287.31, 80.39 -76.48, -2.57 in-in in 8.774 Saltbr-in 3.0941 HRD-in -69.87, -45.12 67.03, 14.87 in-in-out SNCiio in-out ActLoopNT-in 2.9268 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -71.29, 168.54 APE9-dihe-na 70.19, 144.11 APE8-dihe-in -96.47, 160.21 APE8-rot-out 64.82 APE67-dihe-inflip 78.46, -27.02 -43.67, 149.07 APE12-dist-in 13.0905 APE11-dist-in 10.885 APE10-dist-in 6.5705 APE9-dist-in 3.1347 None None None XRAY 2.5 0.193 0.239 A 389.0 355.0 0 27 27 0 [[56, 340]] 1.0 4nm0 Homo sapiens CMGC_GSK3B_HUMAN CMGC 2.5e-70 243.2 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 4NM3A P49841 6 383 420.0 ADP:60409 ATPlike Active DFGin 6.4747 13.947 BLAminus -129.98, -178.05 63.17, 87.87 -103.96, 21.26 289.38, 80.04 -65.46, -16.35 in-in in 8.8058 Saltbr-in 2.7256 HRD-in -69.81, -46.77 71.59, 6.75 in-in-in SNCiii in-in ActLoopNT-in 2.7503 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.34, 169.99 APE9-dihe-na 69.15, 146.37 APE8-dihe-in -83.47, 151.55 APE8-rot-in 296.54 APE67-dihe-inflip 86.0, -31.11 -49.79, 146.79 APE12-dist-in 13.2688 APE11-dist-in 11.4837 APE10-dist-in 6.9065 APE9-dist-in 3.1117 None SEP9 SEP9 XRAY 2.1 0.197 0.242 A 389.0 357.0 2 27 27 0 [[56, 340]] 1.0 4nm3 Homo sapiens CMGC_GSK3B_HUMAN CMGC 2.5e-70 243.2 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 1J1CA P49841 35 388 420.0 ADP:60430 ATPlike Active DFGin 6.8122 13.9298 BLAminus -139.24, -179.75 62.79, 82.17 -97.34, 25.19 286.68, 82.3 -65.83, -19.9 in-in in 8.6015 Saltbr-in 2.6465 HRD-in -68.65, -43.85 68.34, 7.36 in-in-in SNCiii in-in ActLoopNT-in 2.9774 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -90.05, 172.96 APE9-dihe-na 78.17, 130.85 APE8-dihe-in -73.54, 145.97 APE8-rot-in 310.16 APE67-dihe-inflip 99.09, -35.01 -54.43, 141.28 APE12-dist-in 13.0771 APE11-dist-in 11.0674 APE10-dist-in 5.9263 APE9-dist-in 3.1997 None None None XRAY 2.1 0.218 0.242 A 420.0 354.0 0 27 27 0 [[56, 340]] 1.0 1j1c Homo sapiens CMGC_GSK3B_HUMAN CMGC 3.2e-70 242.8 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 1J1CB P49841 23 386 420.0 ADP:60930 ATPlike Active DFGin 6.6935 13.7094 BLAminus -138.27, -179.99 63.33, 82.68 -100.46, 28.2 289.88, 80.26 -70.45, -13.94 in-in in 8.52 Saltbr-in 2.738 HRD-in -67.92, -43.36 67.59, 5.86 in-in-in SNCiii in-in ActLoopNT-in 2.9803 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -91.71, 170.27 APE9-dihe-na 78.71, 139.86 APE8-dihe-in -81.56, 140.05 APE8-rot-in 302.5 APE67-dihe-inflip 101.62, -36.53 -50.52, 137.44 APE12-dist-in 12.8683 APE11-dist-in 11.1277 APE10-dist-in 6.0252 APE9-dist-in 3.2076 None None None XRAY 2.1 0.218 0.242 B 420.0 364.0 0 27 27 0 [[56, 340]] 1.0 1j1c Homo sapiens CMGC_GSK3B_HUMAN CMGC 3.2e-70 242.8 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC MAPK1 MK01_HUMAN 4IZ5A P28482 11 357 360.0 ADP:900 ATPlike Inactive DFGin 6.5744 16.2257 BLAminus -133.03, 170.47 61.68, 96.87 -113.24, 29.97 280.98, 72.88 -75.05, -15.97 in-out in 8.9431 Saltbr-out 6.3365 HRD-in -70.37, -54.19 76.22, -6.05 out-in-out SNCoio in-out ActLoopNT-in 2.8045 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -135.59, 107.64 APE9-dihe-na -86.59, -36.52 APE8-dihe-in -63.86, 130.93 APE8-rot-in 305.07 APE67-dihe-in -64.33, -26.99 -124.19, 30.24 APE12-dist-in 10.0117 APE11-dist-out 7.082 APE10-dist-out 8.2491 APE9-dist-out 10.5104 T185E None None XRAY 3.19 0.245 0.292 A 356.0 347.0 0 31 31 0 [[25, 313]] 1.0 4iz5 Homo sapiens CMGC_MAPK1_HUMAN CMGC 2.5e-85 292.3 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4IZ5B P28482 11 357 360.0 ADP:900 ATPlike Inactive DFGin 6.6142 16.236 BLAminus -130.77, 169.05 63.18, 96.88 -112.33, 27.86 280.9, 72.0 -73.48, -17.21 in-out in 8.9516 Saltbr-out 6.2842 HRD-in -71.55, -52.24 74.21, -4.59 out-in-out SNCoio in-out ActLoopNT-in 2.846 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -135.05, 108.67 APE9-dihe-na -88.18, -35.19 APE8-dihe-in -65.83, 129.75 APE8-rot-in 303.93 APE67-dihe-in -64.9, -24.28 -122.7, 29.42 APE12-dist-in 10.0315 APE11-dist-out 7.0852 APE10-dist-out 8.2498 APE9-dist-out 10.5027 T185E None None XRAY 3.19 0.245 0.292 B 356.0 347.0 0 31 31 0 [[25, 313]] 1.0 4iz5 Homo sapiens CMGC_MAPK1_HUMAN CMGC 2.5e-85 292.3 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4IZ5C P28482 11 357 360.0 ADP:900 ATPlike Inactive DFGin 6.6044 16.2316 BLAminus -131.01, 170.44 62.04, 96.83 -112.78, 28.94 280.74, 73.4 -74.17, -17.63 in-out in 8.9448 Saltbr-out 6.3598 HRD-in -72.88, -51.67 75.48, -6.0 out-in-out SNCoio in-out ActLoopNT-in 2.8678 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -133.99, 108.02 APE9-dihe-na -87.46, -36.5 APE8-dihe-in -65.77, 130.32 APE8-rot-in 303.26 APE67-dihe-in -66.37, -24.82 -122.99, 29.53 APE12-dist-in 10.0145 APE11-dist-out 7.0682 APE10-dist-out 8.2202 APE9-dist-out 10.4967 T185E None None XRAY 3.19 0.245 0.292 C 356.0 347.0 0 31 31 0 [[25, 313]] 1.0 4iz5 Homo sapiens CMGC_MAPK1_HUMAN CMGC 2.5e-85 292.3 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 4IZ5D P28482 11 357 360.0 ADP:900 ATPlike Inactive DFGin 6.6009 16.2317 BLAminus -131.94, 170.02 62.64, 97.08 -112.75, 27.73 280.79, 72.08 -72.23, -17.73 in-out in 8.9604 Saltbr-out 6.3214 HRD-in -71.89, -53.7 75.24, -4.58 out-in-out SNCoio in-out ActLoopNT-in 2.8465 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -135.09, 108.16 APE9-dihe-na -88.37, -35.4 APE8-dihe-in -66.59, 130.93 APE8-rot-in 303.88 APE67-dihe-in -65.41, -25.44 -123.75, 30.53 APE12-dist-in 10.0122 APE11-dist-out 7.0881 APE10-dist-out 8.224 APE9-dist-out 10.4605 T185E None None XRAY 3.19 0.245 0.292 D 356.0 347.0 0 31 31 0 [[25, 313]] 1.0 4iz5 Homo sapiens CMGC_MAPK1_HUMAN CMGC 2.5e-85 292.3 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC PRP4K PRP4K_HUMAN 4IFCA Q13523 668 1005 1007.0 ADP:1101 ATPlike Inactive DFGin 6.3208 14.3632 BLAminus -121.88, -179.85 58.81, 82.85 -100.37, 25.78 288.2, 87.48 -70.57, -26.82 in-in in 8.2572 Saltbr-in 2.8437 HRD-in -62.43, -44.6 59.26, 25.1 in-in-out SNCiio in-out ActLoopNT-in 2.8159 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -73.15, 134.81 APE9-dihe-na 75.99, 141.41 APE8-dihe-in -55.8, 125.16 APE8-rot-in 286.42 APE67-dihe-in -66.36, -24.99 -29.31, -53.31 APE12-dist-out 15.5377 APE11-dist-in 11.8311 APE10-dist-out 8.8713 APE9-dist-in 3.2866 None PTR849 PTR849 XRAY 2.13 0.243 0.256 A 358.0 328.0 10 26 26 0 [[687, 1003]] 1.0 4ifc Homo sapiens CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1.0 301.0 301.0 833 834 835 837 839 717 732 736 812 814 813 815.0 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
CMGC PRP4K PRP4K_HUMAN 4IFCB Q13523 670 1005 1007.0 ADP:1101 ATPlike Inactive DFGin 6.419 14.3427 BLAminus -121.41, 176.18 59.35, 85.75 -102.3, 24.13 289.47, 86.91 -69.6, -26.74 in-in in 8.3192 Saltbr-in 2.7793 HRD-in -64.36, -42.37 58.06, 25.43 in-in-out SNCiio in-out ActLoopNT-in 2.9005 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioi APE10-dihe-na -73.87, 139.78 APE9-dihe-na 75.02, 140.04 APE8-dihe-in -56.36, 124.13 APE8-rot-in 293.29 APE67-dihe-in -65.74, -25.94 -27.6, -52.65 APE12-dist-out 15.5374 APE11-dist-in 11.8086 APE10-dist-out 8.5765 APE9-dist-in 3.2507 None PTR849 PTR849 XRAY 2.13 0.243 0.256 B 358.0 330.0 6 26 26 0 [[687, 1003]] 1.0 4ifc Homo sapiens CMGC_PRP4K_HUMAN CMGC 1.9e-82 282.7 1.0 301.0 301.0 833 834 835 837 839 717 732 736 812 814 813 815.0 871 859 854 853 852 851 850 849 848 768 Serine/threonine-protein kinase PRP4 homolog
CMGC SRPK1 SRPK1_HUMAN 1WBPA Q96SB4 67 655 655.0 ADP:60950 ATPlike Active DFGin 6.0934 14.4839 BLAminus -120.66, 177.09 55.57, 73.12 -93.78, 28.92 297.48, 63.42 -60.8, -41.52 in-in in 9.6161 Saltbr-in 3.5335 HRD-in -64.25, -33.37 61.64, -4.85 in-in-in SNCiii in-in ActLoopNT-in 2.8547 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.23, 175.25 APE9-dihe-na 64.87, 133.49 APE8-dihe-in -68.33, 140.58 APE8-rot-in 294.72 APE67-dihe-in -48.4, -19.96 -25.96, -79.02 APE12-dist-in 12.4206 APE11-dist-in 10.401 APE10-dist-in 7.4554 APE9-dist-in 2.9725 None None None XRAY 2.4 0.228 0.247 A 397.0 350.0 22 25 25 0 [[80, 653]] 1.0 1wbp Homo sapiens CMGC_SRPK1_HUMAN CMGC 2e-139 469.9 1.0 301.0 301.0 496 497 498 500 502 109 124 128 210 212 211 213.0 533 521 516 515 514 513 512 511 510 166 SRSF protein kinase 1
NEK NEK2 NEK2_HUMAN 2W5AA P51955 3 271 445.0 ADP:61280 ATPlike Inactive None 12.6449 15.9152 None -79.34, 164.62 -62.62, 148.1 -64.74, -38.56 187.15, 76.57 112.78, 109.44 out-out out 13.1339 Saltbr-out 14.4222 HRD-out -72.83, 129.73 -137.0, 151.51 out-out-out SNCooo out-out ActLoopNT-out 11.6377 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -50.6, -46.29 APE9-dihe-na -59.22, 149.78 APE8-dihe-in -97.74, 124.68 APE8-rot-in 301.95 APE67-dihe-out -55.08, -31.55 -81.03, 66.49 APE12-dist-out 14.6679 APE11-dist-out 19.1477 APE10-dist-out 20.0287 APE9-dist-out 14.9014 None None None XRAY 1.55 0.173 0.19 A 279.0 259.0 10 28 25 3 [[8, 271]] 1.0 2w5a Homo sapiens NEK_NEK2_HUMAN NEK 7.7e-110 372.3 1.0 256.0 256.0 158 159 160 162 164 37 55 59 138 140 139 141.0 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK NEK7 NEK7_HUMAN 9NFQC Q8TDX7 20 300 302.0 ADP:1301 ATPlike Inactive DFGin 7.3069 11.9804 None -150.16, -164.53 74.32, -54.68 63.51, 118.45 304.42, 170.07 -50.32, 115.41 out-out out 14.52 Saltbr-out 10.4482 HRD-in -75.46, -45.69 71.31, -4.13 out-out-out SNCooo out-out ActLoopNT-out 9.1773 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -73.74, 126.83 APE9-dihe-na 80.61, 29.64 APE8-dihe-in -127.17, 154.0 APE8-rot-out 66.52 APE67-dihe-out -56.05, -43.39 -68.04, 167.92 APE12-dist-out 15.571 APE11-dist-out 14.5314 APE10-dist-out 11.8253 APE9-dist-out 8.4872 None None None XRAY 3.25 0.214 0.261 C 304.0 281.0 0 28 28 0 [[34, 294]] 1.0 9nfq Homo sapiens NEK_NEK7_HUMAN NEK 4.3e-110 373.2 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
NEK NEK7 NEK7_HUMAN 2WQNA Q8TDX7 21 300 302.0 ADP:1301 ATPlike Inactive DFGin 7.3657 14.509 None -71.0, 173.16 -64.84, 135.91 -62.15, 999.0 305.22, 52.49 999.0, 999.0 out-out out 14.0336 Saltbr-out 12.9475 HRD-in -74.75, -50.15 86.13, -19.52 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 77.46 APE8-rot-none 999.0 APE67-dihe-out -63.25, -48.51 -54.4, 143.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.3 0.192 0.221 A 310.0 259.0 21 28 10 18 [[34, 294]] 1.0 2wqn Homo sapiens NEK_NEK7_HUMAN NEK 4.6e-110 373.1 1.0 255.0 255.0 178 179 180 182 184 63 82 86 158 160 159 161.0 218 206 201 200 199 198 197 196 195 112 Serine/threonine-protein kinase Nek7
OTHER BUB1 BUB1_HUMAN 4QPMA O43683 740 1083 1085.0 ADP:61501 ATPlike Inactive DFGin 4.9806 12.0103 BLAminus -120.67, -179.49 71.42, 87.57 -106.61, 23.42 308.95, 170.82 -66.89, -34.13 in-in in 7.7961 Saltbr-in 2.9136 HRD-in -66.14, -48.04 82.18, -4.6 in-in-out SNCiio in-out ActLoopNT-in 2.7633 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -64.85, 156.56 APE9-dihe-na -64.63, -39.16 APE8-dihe-in -93.29, 139.46 APE8-rot-in 316.87 APE67-dihe-in -78.63, -37.4 -63.71, -30.48 APE12-dist-in 11.7254 APE11-dist-out 14.148 APE10-dist-out 10.6353 APE9-dist-out 10.7918 None SEP969 SEP969 XRAY 2.202 0.231 0.269 A 356.0 329.0 15 30 30 0 [[787, 1056]] 1.0 4qpm Homo sapiens OTHER_BUB1_HUMAN BUB 3.8e-136 458.4 1.0 265.0 265.0 945 946 947 949 951 821 830 834 914 916 915 917.0 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN 4QPMB O43683 740 1081 1085.0 ADP:61501 ATPlike Inactive DFGin 5.1011 12.0458 BLAminus -119.58, -176.38 67.12, 86.64 -105.74, 27.36 310.01, 169.79 -71.02, -28.54 in-in in 7.7718 Saltbr-in 2.9014 HRD-in -61.72, -45.96 85.02, -11.94 in-in-out SNCiio in-out ActLoopNT-in 2.7443 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -63.28, 153.27 APE9-dihe-na -53.34, -51.78 APE8-dihe-in -91.15, 141.66 APE8-rot-in 311.67 APE67-dihe-in -72.26, -39.02 -59.96, -32.38 APE12-dist-in 11.6975 APE11-dist-out 14.0616 APE10-dist-out 10.1164 APE9-dist-out 11.0219 None SEP969 SEP969 XRAY 2.202 0.231 0.269 B 356.0 328.0 14 30 30 0 [[787, 1056]] 1.0 4qpm Homo sapiens OTHER_BUB1_HUMAN BUB 3.8e-136 458.4 1.0 265.0 265.0 945 946 947 949 951 821 830 834 914 916 915 917.0 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN 4R8QA O43683 736 1083 1085.0 ADP:1501 ATPlike Inactive DFGin 5.1224 11.8292 BLAminus -125.96, -174.79 66.73, 90.85 -108.81, 15.71 306.38, 172.71 -63.09, -30.66 in-in in 7.7114 Saltbr-in 2.8745 HRD-in -64.09, -49.64 83.12, -3.69 in-in-out SNCiio in-out ActLoopNT-in 2.7626 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iooo APE10-dihe-na -164.58, 163.81 APE9-dihe-na -85.55, 176.61 APE8-dihe-out -73.85, 5.37 APE8-rot-in 315.03 APE67-dihe-out 103.71, -26.99 -140.38, 18.96 APE12-dist-in 11.7437 APE11-dist-out 16.3238 APE10-dist-out 13.2043 APE9-dist-out 6.446 None None None XRAY 2.31 0.226 0.264 A 365.0 332.0 16 30 30 0 [[787, 1056]] 1.0 4r8q Homo sapiens OTHER_BUB1_HUMAN BUB 4.2e-136 458.3 1.0 265.0 265.0 945 946 947 949 951 821 830 834 914 916 915 917.0 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN 5DMZA O43683 735 1083 1085.0 ADP:1101 ATPlike Inactive DFGin 5.221 12.0677 BLAminus -133.45, -169.91 60.82, 85.13 -106.54, 14.57 302.2, 157.68 -62.7, -37.35 in-out in 7.7014 Saltbr-out 3.7639 HRD-in -69.13, -48.67 85.78, -11.89 out-in-out SNCoio in-out ActLoopNT-in 2.8654 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iooi APE10-dihe-na -165.83, 155.63 APE9-dihe-na -80.56, 157.26 APE8-dihe-out -52.44, -38.51 APE8-rot-in 307.01 APE67-dihe-out 105.78, 2.77 -74.96, -12.99 APE12-dist-in 11.7853 APE11-dist-out 16.0361 APE10-dist-out 12.5398 APE9-dist-in 5.9432 None SEP969 SEP969 XRAY 2.4 0.212 0.245 A 365.0 340.0 9 30 30 0 [[787, 1056]] 1.0 5dmz Homo sapiens OTHER_BUB1_HUMAN BUB 4.2e-136 458.3 1.0 265.0 265.0 945 946 947 949 951 821 830 834 914 916 915 917.0 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER BUB1 BUB1_HUMAN 5DMZB O43683 735 1083 1085.0 ADP:1101 ATPlike Inactive DFGin 5.2199 11.8525 BLAminus -128.64, -170.27 62.18, 89.46 -111.04, 16.28 301.8, 159.34 -67.29, -36.18 in-out in 7.5716 Saltbr-out 4.0246 HRD-in -67.97, -51.5 86.46, -15.21 out-in-out SNCoio in-out ActLoopNT-in 2.8449 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_iooi APE10-dihe-na -164.62, 154.63 APE9-dihe-na -71.85, 159.91 APE8-dihe-out -55.62, -36.95 APE8-rot-in 307.18 APE67-dihe-out 117.19, -7.42 -77.21, -19.75 APE12-dist-in 11.5746 APE11-dist-out 15.552 APE10-dist-out 12.2656 APE9-dist-in 5.7424 None SEP969 SEP969 XRAY 2.4 0.212 0.245 B 365.0 340.0 9 30 30 0 [[787, 1056]] 1.0 5dmz Homo sapiens OTHER_BUB1_HUMAN BUB 4.2e-136 458.3 1.0 265.0 265.0 945 946 947 949 951 821 830 834 914 916 915 917.0 987 975 970 969 968 967 966 965 964 867 Mitotic checkpoint serine/threonine-protein kinase BUB1
OTHER CDC7 CDC7_HUMAN 4F99A O00311 41 572 574.0 ADP:601 ATPlike None DFGin 5.8696 13.865 BLAminus -125.0, 176.56 71.88, 86.33 -103.78, 20.73 291.54, 82.68 -65.96, -16.39 in-in in 8.7935 Saltbr-in 3.139 HRD-in -63.98, -49.82 74.42, -3.19 in-in-none SNCiin in-none ActLoopNT-in 2.7316 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -77.05, 117.3 APE8-rot-in 305.41 APE67-dihe-in -66.81, -0.89 -45.84, -42.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.33 0.194 0.241 A 361.0 312.0 42 188 168 20 [[58, 569]] 1.0 4f99 Homo sapiens OTHER_CDC7_HUMAN CMGC 2e-18 137.7 1.0 161.0 295.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 4F9AA O00311 39 572 574.0 ADP:601 ATPlike None DFGin 5.7594 13.9364 BLAminus -128.61, 175.54 70.41, 87.99 -103.92, 20.97 294.06, 81.72 -65.32, -14.75 in-in in 8.7565 Saltbr-in 3.4076 HRD-in -57.32, -50.7 72.28, 5.36 in-in-none SNCiin in-none ActLoopNT-in 2.9281 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -93.93, 115.55 APE8-rot-in 301.45 APE67-dihe-in -62.39, -13.04 -45.16, -41.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.17 0.208 0.25 A 361.0 315.0 41 188 168 20 [[58, 569]] 1.0 4f9a Homo sapiens OTHER_CDC7_HUMAN CMGC 2e-18 137.7 1.0 161.0 295.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 4F9AC O00311 37 572 574.0 ADP:601 ATPlike None DFGin 5.9131 14.2074 BLAminus -118.89, -178.58 68.69, 81.33 -98.73, 26.53 287.38, 89.39 -66.37, -28.9 in-in in 8.8461 Saltbr-in 2.6338 HRD-in -64.95, -54.17 83.11, 0.13 in-in-none SNCiin in-none ActLoopNT-in 2.6428 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-in -84.47, 120.44 APE8-rot-in 299.37 APE67-dihe-in -57.71, -12.62 -43.45, -49.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.17 0.208 0.25 C 361.0 317.0 41 188 168 20 [[58, 569]] 1.0 4f9a Homo sapiens OTHER_CDC7_HUMAN CMGC 2e-18 137.7 1.0 161.0 295.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 0 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 6YA7A O00311 39 573 574.0 ADP:60604 ATPlike None DFGin 5.8885 14.044 BLAminus -126.02, 169.07 75.11, 84.03 -93.96, 22.86 290.05, 97.62 -71.31, -16.58 in-in in 8.9367 Saltbr-in 2.7749 HRD-in -69.05, -41.87 77.4, -14.54 in-in-none SNCiin in-none ActLoopNT-in 2.8118 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 153.99, -157.91 APE8-dihe-in -128.95, 137.92 APE8-rot-in 297.63 APE67-dihe-inflip 100.28, -12.86 -58.0, 134.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.7143 None None None XRAY 1.67 0.158 0.185 A 358.0 345.0 5 188 183 5 [[58, 569]] 1.0 6ya7 Homo sapiens OTHER_CDC7_HUMAN CMGC 2e-18 137.3 1.0 161.0 296.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 375 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER CDC7 CDC7_HUMAN 6YA8A O00311 38 572 574.0 ADP:60601,BEF:60603 ATPlike,Allosteric None DFGin 6.1681 14.0868 BLAminus -118.93, 173.08 76.34, 83.66 -102.33, 21.87 291.62, 81.2 -67.07, -22.7 in-in in 8.7089 Saltbr-in 2.7382 HRD-in -65.76, -44.2 72.35, -4.4 in-in-none SNCiin in-none ActLoopNT-in 2.755 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na -83.06, -154.71 APE8-dihe-in -48.63, 132.1 APE8-rot-in 306.86 APE67-dihe-in -66.07, -7.37 -59.08, -35.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.8876 None None None XRAY 1.79 0.167 0.197 A 359.0 338.0 13 188 175 13 [[58, 569]] 1.0 6ya8 Homo sapiens OTHER_CDC7_HUMAN CMGC 2e-18 137.3 1.0 161.0 296.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 375 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 6D3KA P19525 256 544 551.0 ADP:601 ATPlike Inactive DFGin 6.1925 14.1139 BLAminus -129.83, -165.99 54.1, 79.73 -96.08, 34.77 294.46, 85.4 -58.44, -36.42 in-in in 8.7206 Saltbr-in 3.027 HRD-in -84.66, -50.66 80.44, -19.76 in-in-out SNCiio in-out ActLoopNT-in 2.9759 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 139.0 APE8-rot-out 55.24 APE67-dihe-out -85.5, -25.12 -112.78, 51.79 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.212 0.266 A 323.0 258.0 31 27 17 10 [[175, 537]] 1.0 6d3k Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 3.5e-49 173.8 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 6D3KB P19525 255 541 551.0 ADP:601 ATPlike Inactive DFGin 6.3934 14.2206 BLAminus -124.42, -164.03 49.77, 78.4 -95.78, 27.52 286.59, 80.74 -46.98, -40.31 in-in in 8.5703 Saltbr-in 2.9665 HRD-in -83.22, -38.98 75.5, -28.78 in-in-out SNCiio in-out ActLoopNT-in 3.1489 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -18.31 APE8-rot-in 303.08 APE67-dihe-out -107.33, 146.38 64.92, 69.11 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.212 0.266 B 323.0 254.0 33 27 16 11 [[175, 537]] 1.0 6d3k Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 3.5e-49 173.8 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER EIF2AK2 E2AK2_HUMAN 6D3KC P19525 257 541 551.0 ADP:601 ATPlike Inactive DFGin 6.3125 14.4662 BLAminus -121.59, -161.34 59.64, 70.11 -92.29, 27.04 287.49, 78.94 -65.31, -34.89 in-in in 8.5127 Saltbr-in 2.6756 HRD-in -58.89, -48.8 72.65, -1.02 in-in-out SNCiio in-out ActLoopNT-in 2.8855 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 168.95 APE8-dihe-in -45.87, 135.3 APE8-rot-out 180.18 APE67-dihe-in -61.65, -21.89 -90.59, -3.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.1936 None None None XRAY 2.6 0.212 0.266 C 323.0 258.0 27 27 24 3 [[175, 537]] 1.0 6d3k Homo sapiens OTHER_EIF2AK2_HUMAN OTHER 3.5e-49 173.8 1.0 256.0 256.0 431 432 433 435 437 296 308 312 411 413 412 414.0 470 458 453 452 451 450 449 448 447 367 Interferon-induced, double-stranded RNA-activated protein kinase
OTHER ERN1 ERN1_HUMAN 4YZDA O75460 563 964 977.0 ADP:1002 ATPlike Inactive DFGin 7.1061 13.4537 BLBplus -141.52, 169.79 75.76, 4.13 -62.0, 156.83 53.76, 79.18 72.65, 35.33 out-out out 15.8851 Saltbr-out 13.4097 HRD-in -64.16, -47.27 74.91, -18.55 out-out-out SNCooo out-out ActLoopNT-out 10.5839 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -69.65, 158.55 APE9-dihe-na 98.62, 175.79 APE8-dihe-in -108.17, 135.68 APE8-rot-in 302.59 APE67-dihe-inflip 100.94, -24.59 -56.48, 129.95 APE12-dist-none 999.0 APE11-dist-in 13.4057 APE10-dist-out 8.1612 APE9-dist-in 3.4231 None None None XRAY 3.102 0.234 0.273 A 405.0 383.0 18 31 19 12 [[571, 832]] 1.0 4yzd Homo sapiens OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZDB O75460 563 963 977.0 ADP:1002 ATPlike Inactive DFGin 7.2039 13.1793 BLBplus -141.12, 169.65 69.57, 15.58 -67.08, 155.42 48.06, 78.07 72.22, 36.23 out-out out 15.8795 Saltbr-out 13.1182 HRD-in -63.57, -45.81 74.7, -19.84 out-out-none SNCoon out-none ActLoopNT-out 10.5805 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -69.77, 158.99 APE9-dihe-na 99.89, 174.78 APE8-dihe-in -110.07, 134.42 APE8-rot-in 300.85 APE67-dihe-inflip 103.95, -24.75 -57.78, 133.16 APE12-dist-none 999.0 APE11-dist-in 12.6724 APE10-dist-in 7.5681 APE9-dist-in 3.5283 None None None XRAY 3.102 0.234 0.273 B 405.0 385.0 15 31 19 12 [[571, 832]] 1.0 4yzd Homo sapiens OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 4YZDC O75460 563 964 977.0 ADP:1001 ATPlike Inactive DFGin 7.2921 13.5559 BLBplus -142.06, 170.34 76.33, 5.28 -64.41, 157.35 50.79, 79.33 73.41, 36.41 out-out out 16.1942 Saltbr-out 13.2528 HRD-in -63.95, -47.78 74.02, -20.41 out-out-none SNCoon out-none ActLoopNT-out 10.5812 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -70.78, 158.57 APE9-dihe-na 97.6, 174.43 APE8-dihe-in -111.17, 134.53 APE8-rot-in 303.43 APE67-dihe-inflip 103.93, -24.42 -56.8, 132.74 APE12-dist-none 999.0 APE11-dist-in 12.4096 APE10-dist-in 7.7835 APE9-dist-in 3.412 None None None XRAY 3.102 0.234 0.273 C 405.0 379.0 21 31 19 12 [[571, 832]] 1.0 4yzd Homo sapiens OTHER_ERN1_HUMAN CAMK 2.8e-35 128.1 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 3P23A O75460 563 963 977.0 ADP:1002 ATPlike Inactive DFGin 7.3396 13.7092 BLBplus -135.51, 176.11 64.76, 22.4 -82.8, 150.63 49.7, 79.84 86.4, 10.86 out-out out 16.0885 Saltbr-out 13.0695 HRD-in -67.24, -58.17 81.51, -4.45 out-out-out SNCooo out-out ActLoopNT-out 10.4016 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -84.29, 161.18 APE9-dihe-na 82.17, -162.33 APE8-dihe-in -132.44, 136.42 APE8-rot-in 302.1 APE67-dihe-inflip 108.83, 5.18 -54.01, 119.49 APE12-dist-none 999.0 APE11-dist-in 12.5576 APE10-dist-out 9.1227 APE9-dist-in 3.1961 None None None XRAY 2.7 0.238 0.294 A 432.0 386.0 15 31 19 12 [[571, 832]] 1.0 3p23 Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 3P23B O75460 564 964 977.0 ADP:1002 ATPlike Inactive DFGin 7.4832 13.6464 BLBplus -139.9, 176.5 76.83, 14.87 -83.89, 150.35 55.49, 87.42 97.57, -33.78 out-out out 15.9363 Saltbr-out 12.6575 HRD-in -62.38, -39.7 42.05, 35.85 out-out-out SNCooo out-out ActLoopNT-out 9.7011 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoi APE10-dihe-na 999.0, 143.86 APE9-dihe-na -111.46, -135.27 APE8-dihe-in -106.96, 135.19 APE8-rot-in 295.43 APE67-dihe-inflip 111.53, -14.08 -51.84, 125.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.2132 APE9-dist-in 3.4766 None None None XRAY 2.7 0.238 0.294 B 432.0 386.0 15 31 19 12 [[571, 832]] 1.0 3p23 Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 3P23C O75460 561 964 977.0 ADP:1002 ATPlike Inactive DFGin 7.5436 13.1728 BLBplus -149.53, -176.42 65.18, 18.98 -70.01, 144.07 39.63, 91.88 97.04, -114.33 out-out out 15.805 Saltbr-out 13.146 HRD-in -52.59, -55.72 76.18, 1.65 out-out-out SNCooo out-out ActLoopNT-out 11.1417 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iioi APE10-dihe-na -53.61, -99.6 APE9-dihe-na -77.2, 171.08 APE8-dihe-in -47.05, 145.36 APE8-rot-in 345.28 APE67-dihe-out 116.59, -10.88 85.51, 60.96 APE12-dist-in 12.8381 APE11-dist-in 13.2434 APE10-dist-out 9.3534 APE9-dist-in 3.5072 None None None XRAY 2.7 0.238 0.294 C 432.0 390.0 14 31 20 11 [[571, 832]] 1.0 3p23 Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_HUMAN 3P23D O75460 561 963 977.0 ADP:1002 ATPlike Inactive DFGin 7.4094 13.2631 BLBplus -138.88, 177.03 72.28, 10.83 -71.52, 154.68 50.97, 93.75 83.32, -17.5 out-out out 16.034 Saltbr-out 13.0181 HRD-in -58.06, -54.76 77.4, -2.34 out-out-out SNCooo out-out ActLoopNT-out 10.0574 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nnoi APE10-dihe-na 999.0, 162.88 APE9-dihe-na -149.96, -140.99 APE8-dihe-in -73.3, 139.85 APE8-rot-in 325.01 APE67-dihe-out 115.82, -9.19 91.28, 60.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.1125 APE9-dist-in 4.0378 None None None XRAY 2.7 0.238 0.294 D 432.0 387.0 16 31 17 14 [[571, 832]] 1.0 3p23 Homo sapiens OTHER_ERN1_HUMAN CAMK 3.4e-35 127.9 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER PIK3R4 PI3R4_HUMAN 8SORA Q99570 15 1358 1358.0 ADP:1401 ATPlike Pseudo DFGin 9.418 15.8103 BLBminus -148.68, -163.36 56.86, 40.25 -54.73, 139.1 286.63, 79.79 -95.49, 38.09 out-out out 17.8082 Saltbr-out 21.0895 HRD-in -78.26, -64.21 93.22, -18.74 out-out-out SNCooo out-out ActLoopNT-out 9.1206 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na 53.41, 44.04 APE9-dihe-na -115.24, -10.88 APE8-dihe-out 68.3, 15.78 APE8-rot-na 299.15 APE67-dihe-out -125.94, 101.57 -74.9, 135.12 APE12-dist-out 14.3019 APE11-dist-out 17.974 APE10-dist-out 21.0555 APE9-dist-out 15.9768 None None None EM 3.96 999.0 999.0 A 1358.0 1156.0 28 35 35 0 [[19, 321]] 1.0 8sor Homo sapiens OTHER_PIK3R4_HUMAN PIK3R4 5.8e-151 507.9 1.0 298.0 298.0 165 166 167 169 171 53 73 77 145 147 146 148.0 240 200 195 194 193 192 191 190 189 104 Phosphoinositide 3-kinase regulatory subunit 4
OTHER RNASEL RN5A_HUMAN 4OAUC Q05823 25 719 741.0 ADP:801 ATPlike Pseudo DFGin 6.5293 12.3785 BLAminus -152.72, -178.03 59.98, 103.61 -125.32, 12.02 305.12, 98.0 -75.28, 8.76 in-in in 6.9931 Saltbr-in 2.6229 HRD-in -74.91, -47.94 67.23, 8.17 in-in-na SNCiia in-na ActLoopNT-in 2.9126 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -67.73, 111.98 APE9-dihe-na -66.2, -20.72 APE8-dihe-na -68.67, -28.85 APE8-rot-na 187.68 APE67-dihe-na -72.58, -38.81 -76.25, -36.54 APE12-dist-na 14.0675 APE11-dist-na 16.8747 APE10-dist-na 14.9848 APE9-dist-na 14.3331 H672N None None XRAY 2.6 0.213 0.251 C 699.0 692.0 0 20 20 0 [[353, 594]] 1.0 4oau Homo sapiens OTHER_RNASEL_HUMAN RNASEL 4.1e-136 459.9 1.0 242.0 242.0 502 503 504 506 508 392 404 408 482 484 483 485.0 520 522 517 516 515 514 513 512 511 435 2-5A-dependent ribonuclease
STE MAP2K1 MP2K1_HUMAN 3EQIA Q02750 39 382 393.0 ADP:2 ATPlike Inactive DFGin 6.097 14.1456 BLBplus -145.58, 171.19 59.48, 41.15 -92.75, 128.75 41.67, 88.89 -58.7, 127.06 out-out out 15.2136 Saltbr-out 14.7281 HRD-in -57.14, -59.8 81.96, -12.14 out-out-out SNCooo out-out ActLoopNT-out 10.7022 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -160.04, 114.16 APE9-dihe-na -79.94, 159.35 APE8-dihe-in -52.77, 143.91 APE8-rot-out 201.8 APE67-dihe-in -60.21, -14.42 -106.05, 1.41 APE12-dist-out 20.1478 APE11-dist-out 15.2393 APE10-dist-out 17.2957 APE9-dist-out 9.228 S298N,S299K,Y300F None None XRAY 1.9 0.165 999.0 A 360.0 315.0 29 26 26 0 [[68, 361]] 1.0 3eqi Homo sapiens STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3MBLA Q02750 62 381 393.0 ADP:60535,LSG:60007 ATPlike,Type3 Inactive DFGin 6.3443 13.4033 BLBplus -137.82, 175.17 58.41, 36.59 -88.68, 159.6 41.78, 90.19 -90.36, 101.21 out-out out 15.5918 Saltbr-out 16.0041 HRD-in -72.77, -61.87 90.83, -9.53 out-out-out SNCooo out-out ActLoopNT-out 9.7788 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -62.62, 116.57 APE9-dihe-na -76.67, -13.86 APE8-dihe-out -100.19, -102.3 APE8-rot-out 48.6 APE67-dihe-out -109.33, 135.36 -59.01, 126.17 APE12-dist-out 18.7047 APE11-dist-out 17.8806 APE10-dist-out 19.945 APE9-dist-out 14.4728 None None None XRAY 2.6 0.169 0.215 A 328.0 289.0 31 26 26 0 [[68, 361]] 1.0 3mbl Homo sapiens STE_MAP2K1_HUMAN STE 1.3e-97 332.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 4ARKA Q02750 62 382 393.0 ADP:61383,M3K:61385 ATPlike,Type3 Inactive DFGin 6.213 13.3205 BLBplus -143.7, -171.53 62.76, 23.96 -76.11, 159.51 42.79, 94.02 -85.45, 75.28 out-out out 15.3534 Saltbr-out 15.901 HRD-in -67.47, -65.14 92.89, -4.81 out-out-out SNCooo out-out ActLoopNT-out 9.3292 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -100.98, -15.83 APE9-dihe-na -32.88, 128.59 APE8-dihe-out -40.11, 20.06 APE8-rot-out 186.45 APE67-dihe-out -132.58, 138.09 -155.02, 124.88 APE12-dist-out 16.3492 APE11-dist-out 18.1392 APE10-dist-out 23.5537 APE9-dist-out 14.4262 None None None XRAY 2.6 0.174 0.211 A 341.0 290.0 31 26 26 0 [[68, 361]] 1.0 4ark Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3EQGA Q02750 39 381 393.0 ADP:2,4BM:1 ATPlike,Type3 Inactive DFGin 6.6055 13.7427 BLBplus -138.18, 179.2 59.31, 28.5 -81.55, 153.56 35.8, 92.23 -71.67, 64.14 out-out out 15.4736 Saltbr-out 14.5657 HRD-in -60.95, -65.33 94.63, -12.32 out-out-out SNCooo out-out ActLoopNT-out 9.2307 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -104.38, 152.44 APE9-dihe-na -137.47, 114.08 APE8-dihe-in -13.21, 123.19 APE8-rot-out 216.51 APE67-dihe-in -71.17, -7.71 -101.04, 15.41 APE12-dist-out 19.79 APE11-dist-out 16.5602 APE10-dist-out 18.8547 APE9-dist-out 9.489 S298N,S299K,Y300F None None XRAY 2.5 0.21 0.273 A 360.0 314.0 29 26 26 0 [[68, 361]] 1.0 3eqg Homo sapiens STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 6NYBB Q02750 56 383 393.0 ADP:60601,LCJ:60901 ATPlike,Type3 Inactive DFGin 5.9588 14.0365 BLBplus -152.28, 170.52 57.47, 42.76 -92.93, 161.49 47.46, 85.53 -88.41, 68.49 out-out out 15.4696 Saltbr-out 17.6022 HRD-in -56.15, -54.04 65.39, 11.35 out-out-out SNCooo out-out ActLoopNT-out 8.2916 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -140.81, 127.27 APE9-dihe-na -93.66, 157.79 APE8-dihe-out -110.82, -26.16 APE8-rot-out 55.56 APE67-dihe-out -130.29, 148.43 -119.13, 133.87 APE12-dist-out 17.78 APE11-dist-out 18.3191 APE10-dist-out 22.3789 APE9-dist-out 12.1589 S218A,S222A None None EM 4.1 999.0 999.0 B 415.0 289.0 39 26 26 0 [[68, 361]] 1.0 6nyb Homo sapiens STE_MAP2K1_HUMAN STE 1.3e-96 329.0 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3EQHA Q02750 39 381 393.0 5BM:1,ADP:2 Type3,ATPlike Inactive DFGin 6.8455 13.3483 BLBplus -141.56, 168.5 59.76, 36.07 -79.95, 154.58 28.74, 98.71 -78.77, 88.92 out-out out 15.2501 Saltbr-out 13.9257 HRD-in -70.86, -51.49 82.66, -16.34 out-out-out SNCooo out-out ActLoopNT-out 9.8448 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na 72.18, 69.91 APE9-dihe-na -156.93, 105.03 APE8-dihe-in -35.31, 137.66 APE8-rot-out 209.36 APE67-dihe-in -58.22, -17.3 -105.41, 1.3 APE12-dist-out 17.8887 APE11-dist-out 18.0239 APE10-dist-out 19.2755 APE9-dist-out 9.6547 S298N,S299K,Y300F None None XRAY 2.0 0.192 999.0 A 360.0 314.0 29 26 26 0 [[68, 361]] 1.0 3eqh Homo sapiens STE_MAP2K1_HUMAN STE 1.8e-97 331.7 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE PAK3 PAK3_HUMAN 6FD3A O75914 261 556 559.0 ADP:60603 ATPlike Active DFGin 5.9519 14.1494 BLAminus -133.62, -174.01 64.9, 77.07 -96.85, 18.52 289.09, 83.73 -72.71, -11.5 in-in in 8.938 Saltbr-in 2.7609 HRD-in -71.32, -50.63 74.19, 1.63 in-in-in SNCiii in-in ActLoopNT-in 2.9127 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -141.75, 147.44 APE9-dihe-na 132.72, -161.48 APE8-dihe-in -114.41, 121.22 APE8-rot-in 305.33 APE67-dihe-in -64.48, -19.99 -44.4, -48.2 APE12-dist-in 8.8491 APE11-dist-in 11.3583 APE10-dist-in 5.5763 APE9-dist-in 3.3396 A537D None T8L436 XRAY 1.52 0.176 0.19 A 300.0 296.0 0 28 28 0 [[283, 534]] 1.0 6fd3 Homo sapiens STE_PAK3_HUMAN STE 1.1e-94 322.5 1.0 257.0 257.0 419 420 421 423 425 312 328 332 399 401 400 402.0 459 447 442 441 440 439 438 437 436 358 Serine/threonine-protein kinase PAK 3
STE STK24 STK24_HUMAN 3A7JA Q9Y6E0 25 311 443.0 ADP:60500 ATPlike Active DFGin 6.7468 14.5829 BLAminus -138.67, 168.25 71.5, 79.52 -101.19, 20.06 287.01, 95.64 -64.31, -27.68 in-in in 8.5297 Saltbr-in 2.5524 HRD-in -69.86, -43.49 67.32, -1.05 in-in-in SNCiii in-in ActLoopNT-in 2.7408 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.28, 158.62 APE9-dihe-na 130.53, -164.99 APE8-dihe-in -116.23, 120.86 APE8-rot-in 304.02 APE67-dihe-in -60.63, -23.79 -34.15, -55.13 APE12-dist-in 8.2963 APE11-dist-in 11.1102 APE10-dist-in 5.251 APE9-dist-in 3.2876 None TPO190 TPO190 XRAY 1.5 0.191 0.21 A 303.0 287.0 0 28 28 0 [[36, 286]] 1.0 3a7j Homo sapiens STE_STK24_HUMAN STE 3.6e-100 340.5 1.0 257.0 257.0 173 174 175 177 179 65 82 86 153 155 154 156.0 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 4O27B Q9Y6E0 30 309 443.0 ADP:60500 ATPlike Inactive DFGin 4.8671 13.8197 None -148.38, -173.28 56.25, -124.14 31.74, 82.19 64.76, 101.5 98.89, -78.6 in-in in 8.9372 Saltbr-in 2.9006 HRD-in -80.55, -48.63 69.48, -10.03 in-in-out SNCiio in-out ActLoopNT-in 3.0174 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -123.0, 177.15 APE9-dihe-na 103.58, 170.34 APE8-dihe-in -99.19, 143.02 APE8-rot-out 34.53 APE67-dihe-in -72.39, -25.42 -54.44, -42.62 APE12-dist-in 9.0284 APE11-dist-in 10.879 APE10-dist-in 5.5618 APE9-dist-in 3.6436 T190E None None XRAY 3.185 0.203 0.26 B 281.0 280.0 0 28 28 0 [[36, 286]] 1.0 4o27 Homo sapiens STE_STK24_HUMAN STE 5.5e-100 339.9 1.0 257.0 257.0 173 174 175 177 179 65 82 86 153 155 154 156.0 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STRADA STRAA_HUMAN 8VSUB Q7RTN6 60 401 431.0 ADP:2001 ATPlike Pseudo DFGin 5.3284 13.7435 None -141.72, 9.36 -84.56, 30.72 -65.1, -14.12 305.81, 3.72 -62.58, -31.2 out-none out 10.2295 Saltbr-none 999.0 HRD-out -66.66, 151.23 -136.62, 153.73 none-in-out SNCnio in-out ActLoopNT-in 2.8656 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_iooo APE10-dihe-na -55.51, -37.77 APE9-dihe-na -75.16, -6.37 APE8-dihe-out -108.58, -14.7 APE8-rot-na 180.94 APE67-dihe-in -58.61, -34.89 -50.23, -38.37 APE12-dist-in 8.3418 APE11-dist-out 7.821 APE10-dist-out 13.0573 APE9-dist-out 11.0521 None None None EM 2.86 999.0 999.0 B 429.0 306.0 36 35 35 0 [[69, 379]] 1.0 8vsu Homo sapiens STE_STRADA_HUMAN STE 6.5e-87 297.3 1.0 257.0 257.0 212 213 214 216 218 100 118 122 192 194 193 195.0 261 247 242 241 240 239 238 237 236 148 STE20-related kinase adapter protein alpha
STE TAOK3 TAOK3_HUMAN 6BDNA Q9H2K8 8 314 898.0 ADP:404 ATPlike Active DFGin 6.771 13.8246 BLAminus -136.73, -179.28 62.01, 80.15 -97.31, 23.85 293.38, 102.08 -68.85, -11.35 in-in in 8.4853 Saltbr-in 2.6815 HRD-in -74.02, -52.69 74.7, -5.2 in-in-in SNCiii in-in ActLoopNT-in 2.7971 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.94, 158.28 APE9-dihe-na 130.64, -172.75 APE8-dihe-in -113.55, 120.19 APE8-rot-in 301.22 APE67-dihe-in -62.99, -26.26 -46.03, -46.8 APE12-dist-in 8.2804 APE11-dist-in 11.0397 APE10-dist-in 5.1803 APE9-dist-in 3.3832 R2A,K3A None None XRAY 1.5 0.187 0.214 A 320.0 307.0 0 24 24 0 [[24, 277]] 1.0 6bdn Homo sapiens STE_TAOK3_HUMAN STE 6.3e-90 307.0 4.0 257.0 254.0 164 165 166 168 170 53 72 76 144 146 145 147.0 203 188 183 182 181 180 179 178 177 102 Serine/threonine-protein kinase TAO3
TKL BMPR2 BMPR2_HUMAN 3G2FA Q13873 197 510 1038.0 ADP:900 ATPlike Active DFGin 6.9573 13.9443 BLAminus -131.62, -179.2 66.08, 79.87 -102.79, 27.43 304.26, 96.52 -59.99, -25.3 in-in in 8.1073 Saltbr-in 2.7568 HRD-in -69.81, -50.66 82.19, -10.63 in-in-in SNCiii in-in ActLoopNT-in 2.9811 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.1, -22.11 APE9-dihe-na -73.96, -168.61 APE8-dihe-in -80.16, 127.03 APE8-rot-in 308.56 APE67-dihe-in -65.91, -22.58 -59.75, -41.5 APE12-dist-in 11.4026 APE11-dist-in 12.6299 APE10-dist-in 7.0259 APE9-dist-in 4.0326 None None CAS288,CAS397,CAS496 XRAY 2.35 0.21 0.246 A 336.0 305.0 9 36 27 9 [[202, 503]] 1.0 3g2f Homo sapiens TKL_BMPR2_HUMAN TKL 1.4e-75 260.2 2.0 266.0 265.0 350 351 352 354 356 230 243 247 330 332 331 333.0 405 386 381 380 379 378 377 376 375 280 Bone morphogenetic protein receptor type-2
TKL BMPR2 BMPR2_HUMAN 3G2FB Q13873 198 513 1038.0 ADP:900 ATPlike Active DFGin 6.9679 14.0082 BLAminus -149.7, 179.95 61.07, 87.18 -102.54, 11.93 293.8, 112.47 -56.7, -17.91 in-in in 8.0646 Saltbr-in 2.7316 HRD-in -73.22, -52.25 87.7, -10.0 in-in-in SNCiii in-in ActLoopNT-in 2.9139 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.94, -26.41 APE9-dihe-na -71.73, -175.39 APE8-dihe-in -71.07, 133.08 APE8-rot-in 315.55 APE67-dihe-in -68.07, -13.93 -56.75, -42.89 APE12-dist-in 11.1939 APE11-dist-in 12.1078 APE10-dist-in 6.494 APE9-dist-in 3.7222 None None CAS288,CAS397,CAS496 XRAY 2.35 0.21 0.246 B 336.0 303.0 13 36 23 13 [[202, 503]] 1.0 3g2f Homo sapiens TKL_BMPR2_HUMAN TKL 1.4e-75 260.2 2.0 266.0 265.0 350 351 352 354 356 230 243 247 330 332 331 333.0 405 386 381 380 379 378 377 376 375 280 Bone morphogenetic protein receptor type-2
TKL BMPR2 BMPR2_HUMAN 6UNPB Q13873 197 509 1038.0 ADP:601 ATPlike Active DFGin 6.9166 14.0508 BLAminus -140.56, 176.5 63.35, 76.41 -96.26, 25.8 302.12, 104.12 -61.08, -20.73 in-in in 7.9042 Saltbr-in 2.8646 HRD-in -75.95, -48.17 78.17, -6.91 in-in-in SNCiii in-in ActLoopNT-in 2.977 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.29, -9.38 APE9-dihe-na -69.43, -161.26 APE8-dihe-in -89.59, 127.34 APE8-rot-in 301.19 APE67-dihe-in -48.39, -33.11 -62.11, -43.63 APE12-dist-in 12.0086 APE11-dist-in 12.508 APE10-dist-in 7.0989 APE9-dist-in 4.016 D485G None CAS288,CAS397,CAS496 XRAY 2.3 0.19 0.211 B 363.0 303.0 10 36 28 8 [[202, 503]] 1.0 6unp Homo sapiens TKL_BMPR2_HUMAN TKL 1.1e-74 257.3 2.0 266.0 265.0 350 351 352 354 356 230 243 247 330 332 331 333.0 405 386 381 380 379 378 377 376 375 280 Bone morphogenetic protein receptor type-2
TKL BMPR2 BMPR2_HUMAN 6UNPA Q13873 199 509 1038.0 ADP:601,ADP:602 ATPlike,Allosteric None DFGin 7.015 14.0658 BLAminus -140.5, 177.86 62.51, 75.21 -94.82, 26.77 301.08, 104.11 -62.66, -20.97 in-in in 7.9826 Saltbr-in 2.8316 HRD-in -73.31, -49.03 80.8, -8.07 in-in-none SNCiin in-none ActLoopNT-in 2.9199 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_niii APE10-dihe-na -134.35, -10.44 APE9-dihe-na -70.57, -158.87 APE8-dihe-in -91.29, 127.64 APE8-rot-in 299.54 APE67-dihe-in -49.77, -33.71 -61.84, -45.11 APE12-dist-none 999.0 APE11-dist-in 12.7405 APE10-dist-in 7.2841 APE9-dist-in 4.0925 D485G None CAS288,CAS397,CAS496 XRAY 2.3 0.19 0.211 A 363.0 302.0 9 36 27 9 [[202, 503]] 1.0 6unp Homo sapiens TKL_BMPR2_HUMAN TKL 1.1e-74 257.3 2.0 266.0 265.0 350 351 352 354 356 230 243 247 330 332 331 333.0 405 386 381 380 379 378 377 376 375 280 Bone morphogenetic protein receptor type-2
TKL KSR2 KSR2_HUMAN 7JUQB Q6VAB6 652 932 950.0 ADP:1001 ATPlike Pseudo DFGin 5.7226 13.4298 BLBplus -139.35, 152.22 61.66, 33.54 -71.04, 141.2 52.07, 82.92 82.4, -21.94 out-none out 15.3893 Saltbr-none 999.0 HRD-in -71.47, -51.16 73.41, 1.02 none-out-out SNCnoo out-out ActLoopNT-out 7.4594 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -57.45, -45.23 APE9-dihe-na -90.48, -7.37 APE8-dihe-out -66.85, -54.6 APE8-rot-na 183.3 APE67-dihe-in -71.76, -8.04 -52.06, -44.72 APE12-dist-out 18.4872 APE11-dist-out 15.1028 APE10-dist-out 19.5188 APE9-dist-out 11.9629 None None None XRAY 3.22 0.256 0.288 B 342.0 277.0 4 33 30 3 [[665, 930]] 1.0 7juq Homo sapiens TKL_KSR2_HUMAN TKL 1.5e-70 243.8 2.0 267.0 266.0 802 803 804 806 808 692 710 714 783 785 784 786.0 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TYR ABL1 ABL1_HUMAN 2G2IA P00519 229 502 1130.0 ADP:820 ATPlike Inactive DFGin 6.6309 13.4329 BLAminus -148.4, 173.75 80.3, 76.24 -98.47, 37.85 308.34, 118.79 -64.97, -55.29 in-in in 8.0051 Saltbr-in 3.2474 HRD-out -103.94, 83.88 -55.25, 17.72 in-in-in SNCiii in-in ActLoopNT-in 3.0637 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -140.34, 116.79 APE9-dihe-in -127.46, 160.87 APE8-dihe-in -56.61, 91.87 APE8-rot-na 28.18 APE67-dihe-in -56.4, -10.87 -40.77, -65.33 APE12-dist-na 14.9044 APE11-dist-na 10.5735 APE10-dist-na 12.836 APE9-dist-in 7.3096 H396P None None XRAY 3.12 0.251 0.308 A 287.0 271.0 3 29 29 0 [[242, 495]] 1.0 2g2i Homo sapiens TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2G2IB P00519 232 500 1130.0 ADP:821 ATPlike Inactive DFGin 6.6234 13.7447 BLAminus -144.73, -170.13 58.63, 49.5 -73.16, 23.66 306.98, 113.05 -58.19, -50.38 in-in in 7.7947 Saltbr-in 2.8716 HRD-out -111.21, 97.67 -66.16, -14.66 in-in-in SNCiii in-in ActLoopNT-in 3.4038 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -99.86, 132.09 APE9-dihe-in -111.79, 159.65 APE8-dihe-in -83.23, 82.29 APE8-rot-na 32.48 APE67-dihe-in -53.07, -28.27 -29.82, -59.17 APE12-dist-na 14.9753 APE11-dist-na 10.3404 APE10-dist-na 12.8288 APE9-dist-in 7.6248 H396P None None XRAY 3.12 0.251 0.308 B 287.0 265.0 4 29 29 0 [[242, 495]] 1.0 2g2i Homo sapiens TYR_ABL1_HUMAN TYR 6.9e-100 339.6 1.0 260.0 260.0 380 381 382 384 386 271 286 290 360 362 361 363.0 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ALK ALK_HUMAN 3LCTA Q9UM73 1093 1400 1620.0 ADP:1412 ATPlike Inactive DFGin 6.2665 15.1932 ABAminus -127.22, 10.26 -136.37, 129.73 -130.23, 18.7 291.41, 88.16 -49.74, -46.74 in-none in 8.1003 Saltbr-none 999.0 HRD-in -78.72, -45.58 81.21, -3.39 none-out-out SNCnoo out-out ActLoopNT-out 6.8864 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -94.62, -10.42 APE9-dihe-in -67.88, 140.77 APE8-dihe-in -81.63, 62.42 APE8-rot-na 34.08 APE67-dihe-in -66.16, -16.53 -61.79, -27.56 APE12-dist-na 14.7391 APE11-dist-na 15.1116 APE10-dist-na 9.9808 APE9-dist-out 8.0309 S1281G None None XRAY 2.1 0.207 0.255 A 344.0 308.0 0 30 30 0 [[1116, 1385]] 1.0 3lct Homo sapiens TYR_ALK_HUMAN TYR 5e-90 307.3 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR EGFR EGFR_HUMAN 4RIWB P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.9474 14.5093 None -144.94, -140.84 60.54, -94.56 67.75, 16.38 293.55, 125.63 -72.75, -24.64 in-in in 8.962 Saltbr-in 2.5768 HRD-out -81.5, 87.13 -71.92, 10.44 in-in-none SNCiin in-none ActLoopNT-in 2.9141 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.11 APE8-dihe-in -64.72, 105.47 APE8-rot-na 338.81 APE67-dihe-in -78.09, 0.73 -66.98, -35.92 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.3389 V948R,F997A,L1001A None None XRAY 3.1 0.233 0.287 B 345.0 293.0 4 30 26 4 [[712, 970]] 1.0 4riw Homo sapiens TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIWD P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 6.0156 14.3995 None -147.43, -141.55 60.24, -94.38 68.1, 17.38 294.17, 126.48 -72.23, -23.22 in-in in 8.8454 Saltbr-in 3.0814 HRD-in -78.23, -46.1 60.09, 5.38 in-in-in SNCiii in-in ActLoopNT-in 2.84 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -105.64, 111.47 APE9-dihe-in -129.74, 134.09 APE8-dihe-in -62.84, 106.17 APE8-rot-na 337.89 APE67-dihe-in -78.37, 3.33 -65.15, -34.97 APE12-dist-na 11.3973 APE11-dist-na 9.9458 APE10-dist-na 9.7227 APE9-dist-in 6.0148 V948R,F997A,L1001A None None XRAY 3.1 0.233 0.287 D 345.0 297.0 0 30 30 0 [[712, 970]] 1.0 4riw Homo sapiens TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIXB P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.9187 14.5792 None -139.87, -153.46 71.8, -106.42 74.55, 12.91 300.13, 117.16 -73.01, -18.89 in-in in 8.7784 Saltbr-in 2.8507 HRD-out -79.93, 91.22 -73.37, 9.67 in-in-none SNCiin in-none ActLoopNT-in 2.815 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.04 APE8-dihe-in -57.54, 105.82 APE8-rot-na 336.15 APE67-dihe-in -83.65, 5.55 -71.82, -34.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.6445 V948R,F997A,L1001A None None XRAY 3.1 0.21 0.258 B 345.0 293.0 4 30 26 4 [[712, 970]] 1.0 4rix Homo sapiens TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIXD P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.9838 14.3961 None -138.76, -155.76 70.86, -102.17 73.98, 14.44 299.1, 114.44 -71.0, -18.03 in-in in 8.4327 Saltbr-in 2.1297 HRD-in -75.74, -46.31 59.89, 5.04 in-in-in SNCiii in-in ActLoopNT-in 2.8788 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -117.43, 115.77 APE9-dihe-in -128.43, 136.25 APE8-dihe-in -57.6, 106.59 APE8-rot-na 335.5 APE67-dihe-in -81.04, 4.3 -70.58, -32.32 APE12-dist-na 11.3356 APE11-dist-na 10.1436 APE10-dist-na 10.4275 APE9-dist-in 5.9873 V948R,F997A,L1001A None None XRAY 3.1 0.21 0.258 D 345.0 297.0 0 30 30 0 [[712, 970]] 1.0 4rix Homo sapiens TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIYB P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.9519 14.6551 None -154.99, 131.23 -173.19, -76.87 64.96, 12.46 300.69, 132.23 -71.94, -28.32 in-in in 8.6852 Saltbr-in 2.9501 HRD-out -79.99, 96.69 -77.78, 9.7 in-in-none SNCiin in-none ActLoopNT-in 2.8837 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.59 APE8-dihe-in -76.15, 93.2 APE8-rot-na 346.43 APE67-dihe-in -79.33, 6.83 -64.49, -46.47 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.3497 V948R,F997A,L1001A None None XRAY 2.981 0.221 0.267 B 345.0 293.0 4 30 26 4 [[712, 970]] 1.0 4riy Homo sapiens TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4RIYD P00533 688 984 1210.0 ADP:61001 ATPlike Inactive DFGin 5.8922 14.3982 None -146.72, -160.68 90.34, -82.61 63.94, 14.36 297.22, 112.71 -69.53, -27.12 in-in in 8.3332 Saltbr-in 2.3271 HRD-in -73.91, -45.57 61.02, 4.8 in-in-in SNCiii in-in ActLoopNT-in 2.9763 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -106.34, 113.28 APE9-dihe-in -130.38, 137.58 APE8-dihe-in -69.37, 99.85 APE8-rot-na 344.82 APE67-dihe-in -75.56, 6.57 -58.1, -42.52 APE12-dist-na 11.2323 APE11-dist-na 10.2008 APE10-dist-na 9.9606 APE9-dist-in 6.2575 V948R,F997A,L1001A None None XRAY 2.981 0.221 0.267 D 345.0 297.0 0 30 30 0 [[712, 970]] 1.0 4riy Homo sapiens TYR_EGFR_HUMAN TYR 9.4e-88 299.9 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EPHB1 EPHB1_HUMAN 7KPMA P54762 611 888 984.0 ADP:901 ATPlike Inactive DFGin 6.1477 15.077 None -129.01, -161.15 68.81, 56.56 -103.91, 999.0 293.32, 103.77 999.0, 999.0 in-in in 7.7435 Saltbr-in 2.7086 HRD-in -77.02, -45.59 75.58, -13.35 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 76.94 APE8-rot-na 30.04 APE67-dihe-in -77.93, -6.39 -53.89, -41.84 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None PTR647 PTR647 XRAY 1.608 0.169 0.197 A 279.0 255.0 23 33 10 23 [[619, 880]] 1.0 7kpm Homo sapiens TYR_EPHB1_HUMAN TYR 2.3e-109 370.6 2.0 261.0 260.0 761 762 763 765 767 651 668 672 741 743 742 744.0 806 794 789 788 787 786 785 784 783 698 Ephrin type-B receptor 1
TYR ITK ITK_HUMAN 4M15A Q08881 355 617 620.0 QWS:701,ADP:702 Type3,ATPlike Inactive DFGin 7.9386 15.2905 BLBplus -140.12, 163.53 73.68, 16.28 -64.43, 134.2 34.87, 95.02 79.06, -6.9 out-out out 17.0659 Saltbr-out 16.2542 HRD-in -70.42, -53.15 83.67, -22.02 out-out-out SNCooo out-out ActLoopNT-out 7.7398 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -106.59, 12.56 APE9-dihe-in -62.84, 135.73 APE8-dihe-in -75.4, 60.83 APE8-rot-na 30.68 APE67-dihe-in -61.26, -23.89 -55.9, -32.96 APE12-dist-na 16.8357 APE11-dist-na 19.5146 APE10-dist-na 14.7845 APE9-dist-out 9.1517 None None None XRAY 1.52 0.172 0.186 A 269.0 263.0 0 29 29 0 [[363, 614]] 1.0 4m15 Homo sapiens TYR_ITK_HUMAN TYR 1.2e-92 315.8 1.0 260.0 260.0 499 500 501 503 505 391 406 410 479 481 480 482.0 540 528 523 522 521 520 519 518 517 436 Tyrosine-protein kinase ITK/TSK
TYR JAK1-2 JAK1_HUMAN 5KHWA P23458 867 1153 1154.0 ADP:1201 ATPlike Inactive DFGin 6.2929 13.5952 ABAminus -113.62, -36.19 -113.51, 112.49 -104.48, 28.51 302.05, 98.46 -68.45, -35.55 in-in in 8.0172 Saltbr-in 2.8107 HRD-in -53.69, -54.55 74.32, 4.71 in-in-in SNCiii in-in ActLoopNT-in 2.8167 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.25, 151.86 APE9-dihe-in -139.19, 145.92 APE8-dihe-in -78.07, 75.73 APE8-rot-na 29.65 APE67-dihe-in -77.72, -3.4 -55.44, -31.5 APE12-dist-na 13.0141 APE11-dist-na 7.3323 APE10-dist-na 9.9045 APE9-dist-in 6.0223 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.47 0.188 0.231 A 316.0 278.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 5khw Homo sapiens TYR_JAK1-2_HUMAN TYR 2.6e-87 298.4 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
TYR JAK1-2 JAK1_HUMAN 6C7YA P23458 869 1153 1154.0 ADP:61201 ATPlike Active DFGin 6.0323 13.967 BLAminus -134.15, -164.18 58.49, 84.96 -109.28, 28.04 298.78, 97.45 -66.39, -27.05 in-in in 8.3107 Saltbr-in 2.7325 HRD-in -67.59, -46.53 68.25, 12.43 in-in-in SNCiii in-in ActLoopNT-in 2.9437 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.91, 151.36 APE9-dihe-in -137.76, 143.32 APE8-dihe-in -74.71, 81.76 APE8-rot-na 30.49 APE67-dihe-in -79.4, -2.38 -65.2, -24.66 APE12-dist-na 12.9717 APE11-dist-na 8.0201 APE10-dist-na 10.3436 APE9-dist-in 6.3164 None PTR1035 PTR1035 XRAY 2.499 0.21 0.241 A 286.0 273.0 12 31 31 0 [[583, 847], [875, 1151]] 2.0 6c7y Homo sapiens TYR_JAK1-2_HUMAN TYR 1.8e-87 298.9 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
TYR JAK1-2 JAK1_HUMAN 5KHWB P23458 867 1153 1154.0 ADP:1201 ATPlike Inactive DFGin 6.1878 13.7874 BLAminus -126.62, -174.05 50.66, 92.23 -105.71, 28.99 301.42, 97.18 -62.73, -33.32 in-in in 7.9908 Saltbr-in 2.817 HRD-in -54.38, -55.02 75.74, 4.0 in-in-out SNCiio in-out ActLoopNT-in 2.8112 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -83.14, 18.97 APE9-dihe-in -58.32, 113.18 APE8-dihe-in -82.04, 77.86 APE8-rot-na 28.29 APE67-dihe-in -76.85, -3.42 -56.14, -32.61 APE12-dist-na 7.879 APE11-dist-na 9.6953 APE10-dist-na 6.6047 APE9-dist-in 5.9119 None PTR1034,PTR1035 PTR1034,PTR1035 XRAY 2.47 0.188 0.231 B 316.0 278.0 9 31 31 0 [[583, 847], [875, 1151]] 2.0 5khw Homo sapiens TYR_JAK1-2_HUMAN TYR 2.6e-87 298.4 2.0 259.0 258.0 1020 1021 1022 1024 1026 908 925 929 1000 1002 1001 1003.0 1063 1051 1046 1045 1044 1043 1042 1041 1040 957 Tyrosine-protein kinase JAK1
TYR KIT KIT_HUMAN 1PKGA P10721 567 927 976.0 ADP:1480 ATPlike Inactive DFGin 6.4807 14.1365 BLAminus -130.56, -161.98 47.26, 79.76 -98.59, 34.29 290.92, 88.36 -71.71, -28.0 in-out in 8.1383 Saltbr-out 3.8827 HRD-in -70.61, -44.29 71.47, -6.33 out-in-out SNCoio in-out ActLoopNT-in 2.9813 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out 81.05, 87.98 APE9-dihe-in -123.34, 167.37 APE8-dihe-in -84.87, 64.98 APE8-rot-na 27.08 APE67-dihe-in -64.22, -13.25 -46.84, -45.75 APE12-dist-na 14.8174 APE11-dist-na 9.099 APE10-dist-na 11.173 APE9-dist-in 6.8945 None PTR568,PTR570 PTR568,PTR570 XRAY 2.9 0.229 0.311 A 329.0 292.0 11 30 30 0 [[589, 926]] 1.0 1pkg Homo sapiens TYR_KIT_HUMAN TYR 4.5e-102 346.9 1.0 260.0 260.0 809 810 811 813 815 623 640 644 789 791 790 792.0 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR KIT KIT_HUMAN 1PKGB P10721 566 929 976.0 ADP:1486 ATPlike None DFGin 6.5368 13.8185 BLAminus -133.94, -165.75 57.9, 93.59 -119.64, 36.22 290.23, 87.19 -80.39, -20.36 in-in in 6.9344 Saltbr-in 2.9154 HRD-in -72.14, -51.55 69.69, 17.19 in-in-none SNCiin in-none ActLoopNT-in 2.8877 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 110.55 APE9-dihe-in -141.29, 162.93 APE8-dihe-in -80.26, 78.25 APE8-rot-na 29.66 APE67-dihe-in -62.74, -24.13 -40.98, -43.63 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.7652 APE9-dist-in 6.4939 None PTR568,PTR570 PTR568,PTR570 XRAY 2.9 0.229 0.311 B 329.0 279.0 27 30 17 13 [[589, 926]] 1.0 1pkg Homo sapiens TYR_KIT_HUMAN TYR 4.5e-102 346.9 1.0 260.0 260.0 809 810 811 813 815 623 640 644 789 791 790 792.0 851 839 834 833 832 831 830 829 828 671 Mast/stem cell growth factor receptor Kit
TYR MERTK MERTK_HUMAN 3BRBA Q12866 575 861 999.0 ADP:901 ATPlike Inactive DFGin 6.074 13.6091 BLBplus -149.4, 172.79 64.51, 33.37 -100.26, 164.7 46.71, 83.96 59.32, 174.03 out-out out 13.7503 Saltbr-out 12.5583 HRD-in -82.25, -54.47 71.68, 7.51 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -42.31 APE8-dihe-in -85.78, 61.15 APE8-rot-na 26.09 APE67-dihe-in -74.59, -1.92 -45.39, -40.65 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.3414 None None None XRAY 1.9 0.195 0.24 A 313.0 260.0 27 30 14 16 [[587, 856]] 1.0 3brb Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 3BRBB Q12866 575 863 999.0 ADP:901 ATPlike Inactive DFGin 5.8744 13.3725 BLBplus -148.45, 175.8 65.39, 30.29 -97.01, 161.01 52.76, 80.7 77.95, 168.41 out-out out 13.6964 Saltbr-out 12.5721 HRD-in -83.14, -55.33 72.79, 2.25 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 66.74 APE8-rot-na 30.57 APE67-dihe-in -72.04, -6.33 -47.66, -41.14 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.195 0.24 B 313.0 271.0 18 30 12 18 [[587, 856]] 1.0 3brb Homo sapiens TYR_MERTK_HUMAN TYR 1.4e-92 315.6 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR PTK2 FAK1_HUMAN 2IJMB Q05397 414 689 1052.0 ADP:800 ATPlike Inactive DFGin 6.3234 15.4927 BLBminus -110.71, -163.98 67.21, 81.0 -117.82, 145.96 283.77, 97.43 -64.08, -51.52 in-out in 7.6478 Saltbr-out 3.6757 HRD-in -77.75, -52.2 82.75, -4.55 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -36.05 APE8-dihe-out -75.82, 46.85 APE8-rot-na 30.48 APE67-dihe-in -72.2, -5.65 -47.65, -46.85 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.6994 None None None XRAY 2.187 0.211 0.271 B 281.0 261.0 15 29 14 15 [[422, 678]] 1.0 2ijm Homo sapiens TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR PTK2 FAK1_HUMAN 1MP8A Q05397 414 686 1052.0 ADP:800 ATPlike Inactive None 999.0 999.0 None -89.07, -172.44 90.39, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 7.4463 Saltbr-in 3.0967 HRD-in -74.41, -44.19 70.37, -1.26 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 139.38 APE8-dihe-in -79.05, 61.98 APE8-rot-na 29.35 APE67-dihe-in -62.59, -13.79 -46.47, -46.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.0702 None None None XRAY 1.6 0.188 0.23 A 281.0 252.0 21 29 10 19 [[422, 678]] 1.0 1mp8 Homo sapiens TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR TYK2-2 TYK2_HUMAN 4GVJA P29597 889 1176 1187.0 ADP:61201 ATPlike Inactive DFGin 6.2651 13.7524 BLAminus -124.99, -169.67 58.4, 84.34 -100.6, 24.1 294.23, 90.13 -57.35, -28.35 in-in in 8.284 Saltbr-in 2.6985 HRD-in -78.85, -48.62 71.47, -0.89 in-in-out SNCiio in-out ActLoopNT-in 2.8421 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -90.25, 6.85 APE9-dihe-in -64.48, 128.39 APE8-dihe-in -76.05, 68.17 APE8-rot-na 27.93 APE67-dihe-in -72.65, -6.35 -49.95, -35.24 APE12-dist-na 9.9682 APE11-dist-na 13.0361 APE10-dist-na 9.6495 APE9-dist-in 6.8446 C936A,Q969A,E971A,K972A,C1142A None None XRAY 2.03 0.19 0.231 A 302.0 288.0 0 31 31 0 [[589, 868], [897, 1171]] 2.0 4gvj Homo sapiens TYR_TYK2-2_HUMAN TYR 9.4e-82 280.2 2.0 260.0 259.0 1040 1041 1042 1044 1046 930 947 951 1020 1022 1021 1023.0 1083 1071 1066 1065 1064 1063 1062 1061 1060 979 Non-receptor tyrosine-protein kinase TYK2
OTHER STT7 C1EBN1_MICCC 4IX4A C1EBN1 151 489 489.0 ADP:60601 none Inactive None 999.0 999.0 None -124.77, 172.55 68.64, 78.1 -90.38, 21.25 292.81, 157.07 -65.27, -19.84 none-na none 999.0 Saltbr-na 999.0 HRD-na- -69.85, -47.17 71.62, 4.08 na-in-none SNCain in-none ActLoopNT-in 2.9597 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.499 0.163 0.199 A 350.0 339.0 0 -337 -337 0 [[62, 488]] 1.0 4ix4 Micromonas commoda OTHER_STT7_MICCC CMGC 1.3e-08 61.8 104.0 156.0 81.0 337 338 339 341 343 0 0 0 315 317 316 318.0 0 0 0 0 0 0 0 0 0 0 Protein kinase domain-containing protein
OTHER STT7 C1EBN1_MICCC 4IX4B C1EBN1 151 489 489.0 ADP:60601 none Inactive None 999.0 999.0 None -124.06, 172.31 67.36, 81.18 -93.11, 18.85 292.92, 160.57 -65.85, -21.57 none-na none 999.0 Saltbr-na 999.0 HRD-na- -69.18, -45.52 70.51, 2.0 na-in-none SNCain in-none ActLoopNT-in 2.9526 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.499 0.163 0.199 B 350.0 339.0 0 -337 -337 0 [[62, 488]] 1.0 4ix4 Micromonas commoda OTHER_STT7_MICCC CMGC 1.3e-08 61.8 104.0 156.0 81.0 337 338 339 341 343 0 0 0 315 317 316 318.0 0 0 0 0 0 0 0 0 0 0 Protein kinase domain-containing protein
OTHER STT7 C1EBN1_MICCC 4IX6A C1EBN1 151 489 489.0 ADP:60601 none Inactive None 999.0 999.0 None -121.42, 171.38 68.63, 78.17 -88.85, 21.64 296.86, 161.4 -62.59, -24.51 none-na none 999.0 Saltbr-na 999.0 HRD-na- -70.26, -46.59 73.56, 1.3 na-in-none SNCain in-none ActLoopNT-in 2.9486 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.6 0.174 0.193 A 350.0 339.0 0 -337 -337 0 [[62, 488]] 1.0 4ix6 Micromonas commoda OTHER_STT7_MICCC CMGC 1.3e-08 61.8 104.0 156.0 81.0 337 338 339 341 343 0 0 0 315 317 316 318.0 0 0 0 0 0 0 0 0 0 0 Protein kinase domain-containing protein
OTHER STT7 C1EBN1_MICCC 4IX6B C1EBN1 151 489 489.0 ADP:60601 none Inactive None 999.0 999.0 None -120.88, 168.28 70.6, 77.38 -87.7, 20.1 294.13, 158.65 -62.82, -23.17 none-na none 999.0 Saltbr-na 999.0 HRD-na- -69.85, -45.21 71.7, -0.13 na-in-none SNCain in-none ActLoopNT-in 2.9667 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.6 0.174 0.193 B 350.0 339.0 0 -337 -337 0 [[62, 488]] 1.0 4ix6 Micromonas commoda OTHER_STT7_MICCC CMGC 1.3e-08 61.8 104.0 156.0 81.0 337 338 339 341 343 0 0 0 315 317 316 318.0 0 0 0 0 0 0 0 0 0 0 Protein kinase domain-containing protein
TKL RIPK A0A811MS43_9POAL 8HODA A0A811MS43 82 379 435.0 ADP:60401 ATPlike Inactive DFGin 5.8334 13.3727 BLBplus -121.78, 161.33 63.78, 18.48 -72.74, 142.38 54.34, 88.33 69.05, 9.41 out-out out 13.9488 Saltbr-out 11.8453 HRD-out -80.81, 162.08 -71.22, -39.02 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -63.8, 122.58 APE9-dihe-na 79.64, 3.1 APE8-dihe-in -72.72, 144.78 APE8-rot-out 54.39 APE67-dihe-out 108.47, -0.29 -117.76, 31.22 APE12-dist-out 17.5773 APE11-dist-out 21.1323 APE10-dist-out 20.0913 APE9-dist-out 12.2033 S262A,T263A None None XRAY 1.95 0.201 0.228 A 326.0 279.0 19 30 21 9 [[97, 377]] 1.0 8hod Miscanthus lutarioriparius TKL_RIPK_9POAL TKL 6.7e-60 208.9 4.0 266.0 263.0 245 246 247 249 251 133 149 153 225 227 226 228.0 287 275 270 269 268 267 266 265 264 179 non-specific serine/threonine protein kinase
AGC PRKACA KAPCA_MOUSE 4NTTB P05132 11 351 351.0 ADP:60401 ATPlike Inactive DFGin 6.5417 14.8798 ABAminus -93.85, -35.44 -119.41, 118.31 -113.9, 43.83 296.85, 78.9 -65.87, -49.34 in-none in 9.8688 Saltbr-none 999.0 HRD-in -94.05, -37.34 60.44, 1.66 none-in-in SNCnii in-in ActLoopNT-in 2.7867 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -166.4, 146.42 APE9-dihe-na 126.7, -158.4 APE8-dihe-in -116.99, 137.33 APE8-rot-in 273.8 APE67-dihe-in -64.02, -34.69 -52.94, -43.07 APE12-dist-in 7.7129 APE11-dist-in 10.7197 APE10-dist-in 5.2983 APE9-dist-in 4.164 K8C TPO198,SEP339 TPO198,SEP339 XRAY 3.5 0.23 0.284 B 350.0 341.0 0 25 25 0 [[44, 298]] 1.0 4ntt Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4O21A P05132 16 351 351.0 ADP:60401 ATPlike Active DFGin 6.0367 14.4393 BLAminus -125.27, 173.53 70.53, 83.75 -96.26, 25.58 272.04, 54.28 -57.91, -27.19 in-in in 8.9531 Saltbr-in 2.7155 HRD-in -83.95, -57.84 75.15, 8.54 in-in-in SNCiii in-in ActLoopNT-in 2.9043 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.15, 164.3 APE9-dihe-na 125.14, -151.92 APE8-dihe-in -125.51, 129.66 APE8-rot-in 308.07 APE67-dihe-in -63.53, -19.17 -43.91, -48.76 APE12-dist-in 8.0396 APE11-dist-in 11.4602 APE10-dist-in 5.9112 APE9-dist-in 3.4511 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.95 0.17 0.215 A 342.0 336.0 0 25 25 0 [[44, 298]] 1.0 4o21 Mus musculus AGC_PRKACA_MOUSE AGC 1.4e-94 322.2 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 1L3RE P05132 2 351 351.0 ADP:60381 ATPlike Active DFGin 5.7538 14.4402 BLAminus -119.14, -174.46 57.18, 81.19 -93.77, 20.31 270.88, 52.04 -50.0, -37.57 in-in in 9.0231 Saltbr-in 2.7924 HRD-in -82.45, -54.36 70.16, 7.26 in-in-in SNCiii in-in ActLoopNT-in 2.9201 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.84, 161.06 APE9-dihe-na 132.7, -149.01 APE8-dihe-in -131.06, 132.91 APE8-rot-in 298.56 APE67-dihe-in -55.27, -27.25 -33.24, -62.94 APE12-dist-in 8.1978 APE11-dist-in 11.2333 APE10-dist-in 5.8253 APE9-dist-in 3.3679 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 2.0 0.205 0.232 E 350.0 341.0 0 25 25 0 [[44, 298]] 1.0 1l3r Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DH5A P05132 16 351 351.0 ADP:60403 ATPlike Active DFGin 6.1214 14.3392 BLAminus -125.12, -179.76 61.4, 85.13 -97.61, 27.77 279.05, 62.21 -46.99, -44.52 in-in in 9.0432 Saltbr-in 2.5524 HRD-in -77.92, -53.51 67.68, 1.05 in-in-in SNCiii in-in ActLoopNT-in 2.9684 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.88, 153.17 APE9-dihe-na 132.88, -161.89 APE8-dihe-in -112.07, 131.8 APE8-rot-in 304.21 APE67-dihe-in -57.01, -23.17 -41.47, -55.69 APE12-dist-in 8.2186 APE11-dist-in 11.6017 APE10-dist-in 6.0711 APE9-dist-in 3.87 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.2 0.187 0.222 A 350.0 336.0 0 25 25 0 [[44, 298]] 1.0 4dh5 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 5JR7A P05132 14 351 351.0 ADP:60400 ATPlike Active DFGin 5.7387 13.6907 BLAminus -145.14, 176.28 64.37, 76.68 -85.75, 18.89 294.14, 59.99 -43.66, -41.86 in-in in 8.6743 Saltbr-in 2.7095 HRD-in -93.38, -54.67 74.91, 7.39 in-in-in SNCiii in-in ActLoopNT-in 2.945 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.46, 148.2 APE9-dihe-na 147.95, -159.28 APE8-dihe-in -109.66, 131.32 APE8-rot-in 258.88 APE67-dihe-in -65.5, -25.8 -38.64, -53.47 APE12-dist-in 8.0144 APE11-dist-in 10.772 APE10-dist-in 5.5284 APE9-dist-in 3.8782 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.56 0.269 0.322 A 350.0 338.0 0 25 25 0 [[44, 298]] 1.0 5jr7 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 5JR7C P05132 14 351 351.0 ADP:60400 ATPlike Active DFGin 5.8995 13.1635 BLAminus -138.79, 176.44 54.89, 86.07 -89.1, 7.67 290.95, 62.79 -41.83, -37.01 in-in in 8.1848 Saltbr-in 3.1954 HRD-in -79.11, -50.37 72.48, -21.93 in-in-in SNCiii in-in ActLoopNT-in 2.8194 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.28, 123.46 APE9-dihe-na 160.31, -160.86 APE8-dihe-in -110.49, 124.04 APE8-rot-in 311.35 APE67-dihe-in -70.47, -24.34 -45.9, -42.95 APE12-dist-in 8.1626 APE11-dist-in 10.628 APE10-dist-in 5.0018 APE9-dist-in 4.2619 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.56 0.269 0.322 C 350.0 338.0 0 25 25 0 [[44, 298]] 1.0 5jr7 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 7UJXE P05132 16 351 351.0 ADP:60401 ATPlike Active DFGin 5.731 14.3568 BLAminus -121.93, 179.51 64.92, 83.56 -91.91, 29.5 277.22, 63.03 -64.62, -28.12 in-in in 9.1028 Saltbr-in 2.8121 HRD-in -86.19, -57.72 74.11, 16.74 in-in-in SNCiii in-in ActLoopNT-in 2.9312 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.48, 155.47 APE9-dihe-na 127.23, -161.98 APE8-dihe-in -111.77, 133.52 APE8-rot-in 302.04 APE67-dihe-in -65.07, -18.97 -50.87, -44.77 APE12-dist-in 8.1906 APE11-dist-in 11.5001 APE10-dist-in 5.9613 APE9-dist-in 4.0077 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.4 0.133 0.176 E 350.0 336.0 0 25 25 0 [[44, 298]] 1.0 7ujx Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 7V0GE P05132 17 351 351.0 ADP:60401 ATPlike Active DFGin 5.7389 14.3189 BLAminus -119.5, 177.58 67.43, 82.74 -91.45, 25.21 276.8, 64.92 -62.46, -26.34 in-in in 9.0699 Saltbr-in 2.8017 HRD-in -88.93, -50.41 71.3, 15.33 in-in-in SNCiii in-in ActLoopNT-in 2.9568 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.52, 156.77 APE9-dihe-na 130.04, -162.37 APE8-dihe-in -114.97, 131.2 APE8-rot-in 299.52 APE67-dihe-in -60.0, -22.75 -47.18, -49.61 APE12-dist-in 8.1738 APE11-dist-in 11.5422 APE10-dist-in 6.0368 APE9-dist-in 3.9649 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.63 0.118 0.163 E 350.0 335.0 0 25 25 0 [[44, 298]] 1.0 7v0g Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IADA P05132 15 351 351.0 ADP:60403 ATPlike Active DFGin 5.6579 14.362 BLAminus -130.04, -179.13 63.0, 77.66 -87.34, 22.78 276.11, 53.54 -55.12, -31.28 in-in in 9.0855 Saltbr-in 2.8296 HRD-in -93.22, -52.19 70.15, 14.14 in-in-in SNCiii in-in ActLoopNT-in 2.9352 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.54, 160.6 APE9-dihe-na 133.65, -143.98 APE8-dihe-in -130.05, 134.5 APE8-rot-in 298.49 APE67-dihe-in -67.08, -22.74 -48.94, -44.54 APE12-dist-in 8.0511 APE11-dist-in 11.5496 APE10-dist-in 6.0873 APE9-dist-in 3.5214 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.9 0.189 0.243 A 356.0 337.0 0 25 25 0 [[44, 298]] 1.0 4iad Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IAFA P05132 16 351 351.0 ADP:60403 ATPlike Active DFGin 5.9427 14.1301 BLAminus -121.29, 178.82 64.06, 84.8 -98.0, 27.2 281.56, 65.38 -51.93, -33.25 in-in in 8.8711 Saltbr-in 2.6687 HRD-in -76.48, -53.65 65.3, 9.94 in-in-in SNCiii in-in ActLoopNT-in 2.9738 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.4, 160.11 APE9-dihe-na 128.66, -151.44 APE8-dihe-in -123.86, 135.06 APE8-rot-in 298.27 APE67-dihe-in -57.84, -25.84 -42.55, -55.44 APE12-dist-in 8.1629 APE11-dist-in 11.523 APE10-dist-in 5.9727 APE9-dist-in 3.5632 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.2 0.16 0.192 A 356.0 336.0 0 25 25 0 [[44, 298]] 1.0 4iaf Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IAIA P05132 16 351 351.0 ADP:60403 ATPlike Active DFGin 5.4651 14.5028 BLAminus -125.1, 176.4 64.24, 81.88 -90.74, 22.64 269.91, 49.4 -55.45, -35.99 in-in in 9.1007 Saltbr-in 2.7138 HRD-in -91.06, -49.32 68.79, 15.16 in-in-in SNCiii in-in ActLoopNT-in 2.9385 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.75, 156.86 APE9-dihe-na 141.29, -148.36 APE8-dihe-in -128.24, 130.8 APE8-rot-in 300.02 APE67-dihe-in -62.27, -23.0 -47.39, -47.75 APE12-dist-in 7.9453 APE11-dist-in 11.4584 APE10-dist-in 5.8673 APE9-dist-in 3.6084 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.55 0.171 0.209 A 356.0 336.0 0 25 25 0 [[44, 298]] 1.0 4iai Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IAKA P05132 15 351 351.0 ADP:60403 ATPlike Active DFGin 5.7052 14.5691 BLAminus -126.92, 179.61 63.08, 81.74 -90.27, 23.65 270.26, 53.44 -59.05, -31.45 in-in in 8.9848 Saltbr-in 2.7471 HRD-in -94.54, -49.89 67.85, 16.15 in-in-in SNCiii in-in ActLoopNT-in 2.9098 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.92, 164.74 APE9-dihe-na 131.87, -148.57 APE8-dihe-in -130.85, 127.67 APE8-rot-in 297.68 APE67-dihe-in -61.28, -21.91 -43.91, -50.7 APE12-dist-in 7.9618 APE11-dist-in 11.4433 APE10-dist-in 5.9794 APE9-dist-in 3.5447 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.6 0.185 0.222 A 356.0 337.0 0 25 25 0 [[44, 298]] 1.0 4iak Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IAYA P05132 16 351 351.0 ADP:60403 ATPlike Active DFGin 5.806 14.2571 BLAminus -131.74, 174.05 67.76, 85.89 -95.28, 20.31 273.12, 61.73 -48.17, -36.05 in-in in 9.0392 Saltbr-in 2.9406 HRD-in -89.87, -50.65 68.98, 10.01 in-in-in SNCiii in-in ActLoopNT-in 3.055 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.39, 159.46 APE9-dihe-na 132.54, -148.24 APE8-dihe-in -127.91, 130.95 APE8-rot-in 300.76 APE67-dihe-in -63.09, -19.35 -45.58, -49.88 APE12-dist-in 8.0893 APE11-dist-in 11.4657 APE10-dist-in 5.991 APE9-dist-in 3.8226 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.0 0.182 0.227 A 356.0 336.0 0 25 25 0 [[44, 298]] 1.0 4iay Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IAZA P05132 15 351 351.0 ADP:60403 ATPlike Active DFGin 6.1438 14.6353 BLAminus -132.33, 171.23 62.84, 84.78 -94.94, 21.85 278.49, 61.31 -54.74, -28.93 in-in in 9.2192 Saltbr-in 2.747 HRD-in -95.03, -54.93 73.76, 14.73 in-in-in SNCiii in-in ActLoopNT-in 3.017 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.57, 164.74 APE9-dihe-na 127.12, -150.82 APE8-dihe-in -127.02, 138.46 APE8-rot-in 303.51 APE67-dihe-in -63.11, -25.72 -51.71, -47.83 APE12-dist-in 7.9634 APE11-dist-in 11.5144 APE10-dist-in 5.9788 APE9-dist-in 3.5741 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.85 0.201 0.248 A 356.0 337.0 0 25 25 0 [[44, 298]] 1.0 4iaz Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IB0A P05132 15 351 351.0 ADP:60403 ATPlike Active DFGin 5.7134 14.4391 BLAminus -123.68, 176.86 65.62, 82.22 -94.42, 18.76 272.15, 51.12 -47.84, -35.86 in-in in 9.0645 Saltbr-in 3.0231 HRD-in -84.67, -55.05 71.31, 12.11 in-in-in SNCiii in-in ActLoopNT-in 2.8861 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.67, 157.49 APE9-dihe-na 139.08, -144.95 APE8-dihe-in -131.16, 131.55 APE8-rot-in 306.17 APE67-dihe-in -61.31, -24.54 -46.0, -48.78 APE12-dist-in 8.0592 APE11-dist-in 11.5164 APE10-dist-in 5.9694 APE9-dist-in 3.6924 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.87 0.219 0.287 A 356.0 337.0 0 25 25 0 [[44, 298]] 1.0 4ib0 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IB1A P05132 14 351 351.0 ADP:60403 ATPlike Active DFGin 5.6556 14.4434 BLAminus -126.58, 171.72 66.62, 80.69 -90.79, 23.58 274.18, 53.88 -53.03, -31.34 in-in in 9.1208 Saltbr-in 2.6907 HRD-in -82.93, -51.49 69.93, 14.85 in-in-in SNCiii in-in ActLoopNT-in 2.9803 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.64, 163.58 APE9-dihe-na 133.1, -151.37 APE8-dihe-in -125.38, 138.08 APE8-rot-in 304.1 APE67-dihe-in -60.15, -23.69 -50.01, -49.7 APE12-dist-in 7.9604 APE11-dist-in 11.404 APE10-dist-in 5.9611 APE9-dist-in 3.6354 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.63 0.196 0.223 A 356.0 338.0 0 25 25 0 [[44, 298]] 1.0 4ib1 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IB3A P05132 13 351 351.0 ADP:60401 ATPlike Active DFGin 5.973 14.2146 BLAminus -125.69, 173.12 66.37, 84.97 -98.59, 21.41 276.57, 60.51 -51.27, -29.52 in-in in 8.9902 Saltbr-in 2.7598 HRD-in -77.27, -49.79 61.58, 13.48 in-in-in SNCiii in-in ActLoopNT-in 2.8695 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.06, 160.46 APE9-dihe-na 127.6, -161.57 APE8-dihe-in -110.98, 129.89 APE8-rot-in 305.68 APE67-dihe-in -58.89, -23.07 -39.61, -54.94 APE12-dist-in 8.0781 APE11-dist-in 11.5224 APE10-dist-in 5.9229 APE9-dist-in 3.5677 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.2 0.182 0.228 A 356.0 339.0 0 25 25 0 [[44, 298]] 1.0 4ib3 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4XW6A P05132 15 351 351.0 ADP:60403 ATPlike Active DFGin 5.9823 14.431 BLAminus -130.68, 178.48 65.03, 84.15 -99.24, 23.41 276.01, 56.03 -60.45, -23.49 in-in in 9.1497 Saltbr-in 2.7348 HRD-in -94.59, -52.61 68.2, 15.9 in-in-in SNCiii in-in ActLoopNT-in 2.7909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.91, 154.59 APE9-dihe-na 136.7, -154.91 APE8-dihe-in -121.39, 127.95 APE8-rot-in 293.9 APE67-dihe-in -62.75, -24.38 -45.59, -46.76 APE12-dist-in 8.0512 APE11-dist-in 11.6319 APE10-dist-in 6.051 APE9-dist-in 3.787 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.9 0.186 0.265 A 356.0 337.0 0 25 25 0 [[44, 298]] 1.0 4xw6 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 6E21A P05132 16 351 351.0 ADP:60403 ATPlike Active DFGin 5.5937 14.0551 BLAminus -122.61, 176.37 63.02, 83.41 -94.2, 28.27 284.3, 46.09 -48.88, -41.13 in-in in 9.0287 Saltbr-in 2.6073 HRD-in -74.35, -56.8 67.48, 11.51 in-in-in SNCiii in-in ActLoopNT-in 2.9072 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.7, 159.01 APE9-dihe-na 131.41, -152.84 APE8-dihe-in -125.29, 130.56 APE8-rot-in 303.23 APE67-dihe-in -58.42, -25.04 -35.36, -60.06 APE12-dist-in 8.0433 APE11-dist-in 11.5842 APE10-dist-in 6.0224 APE9-dist-in 3.5802 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.0 0.187 0.217 A 356.0 336.0 0 25 25 0 [[44, 298]] 1.0 6e21 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 1JBPE P05132 10 351 351.0 ADP:60381 ATPlike Inactive DFGin 6.1283 14.0345 BLAminus -131.98, 178.81 60.97, 83.81 -101.93, 15.49 276.81, 71.17 -55.35, -24.18 in-in in 8.8688 Saltbr-in 2.7492 HRD-out -93.99, 130.53 -128.02, 39.83 in-in-in SNCiii in-in ActLoopNT-in 2.8856 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.07, 156.95 APE9-dihe-na 132.9, -168.64 APE8-dihe-in -109.4, 126.7 APE8-rot-in 297.85 APE67-dihe-in -61.28, -20.5 -33.82, -53.02 APE12-dist-in 8.1215 APE11-dist-in 11.4477 APE10-dist-in 6.0125 APE9-dist-in 3.8617 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.2 0.175 999.0 E 350.0 342.0 0 25 25 0 [[44, 298]] 1.0 1jbp Mus musculus AGC_PRKACA_MOUSE AGC 1.6e-94 321.9 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 1RDQE P05132 2 351 351.0 ADP:60599,ATP:60600 ATPlike,ATPlike Active DFGin 5.7065 14.5148 BLAminus -117.27, 178.71 64.74, 81.19 -90.07, 21.82 270.96, 52.48 -58.25, -31.62 in-in in 9.0905 Saltbr-in 2.719 HRD-in -91.16, -53.36 73.19, 12.39 in-in-in SNCiii in-in ActLoopNT-in 2.9357 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.91, 159.57 APE9-dihe-na 132.64, -151.85 APE8-dihe-in -127.7, 133.09 APE8-rot-in 298.45 APE67-dihe-in -59.33, -27.24 -47.42, -47.34 APE12-dist-in 8.1158 APE11-dist-in 11.4138 APE10-dist-in 5.8307 APE9-dist-in 3.5208 Y205A TPO198,SEP339 TPO198,SEP339 XRAY 1.26 0.132 0.162 E 350.0 342.0 0 25 25 0 [[44, 298]] 1.0 1rdq Mus musculus AGC_PRKACA_MOUSE AGC 1.1e-92 315.9 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4NTTA P05132 11 351 351.0 ADP:60401 ATPlike Inactive DFGin 6.2546 15.2208 None 58.0, -132.96 -135.23, 163.83 -122.73, 17.77 281.43, 74.72 -41.46, -50.2 in-out in 9.9815 Saltbr-out 4.1938 HRD-in -65.11, -40.77 60.9, 3.38 out-in-in SNCoii in-in ActLoopNT-in 2.8637 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.9, 118.31 APE9-dihe-na 164.12, -173.28 APE8-dihe-in -108.19, 123.7 APE8-rot-in 267.93 APE67-dihe-in -75.4, -22.82 -40.35, -37.34 APE12-dist-in 8.1876 APE11-dist-in 11.1589 APE10-dist-in 5.5421 APE9-dist-in 4.3211 None TPO198,SEP339 TPO198,SEP339 XRAY 3.5 0.23 0.284 A 350.0 341.0 0 25 25 0 [[44, 298]] 1.0 4ntt Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CAMK CAMK2A KCC2A_MOUSE 7B57B P11798 5 307 478.0 ADP:603 ATPlike Active DFGin 6.6116 14.0811 BLAminus -127.42, 175.73 58.47, 86.34 -93.82, 26.41 288.57, 77.62 -63.18, -29.51 in-in in 8.7899 Saltbr-in 2.7985 HRD-in -66.41, -49.66 65.98, 1.57 in-in-in SNCiii in-in ActLoopNT-in 2.9327 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.13, 142.7 APE9-dihe-na 131.67, 177.43 APE8-dihe-in -91.43, 131.98 APE8-rot-in 302.75 APE67-dihe-in -62.31, -16.39 -48.04, -47.99 APE12-dist-in 10.3678 APE11-dist-in 11.4404 APE10-dist-in 5.7432 APE9-dist-in 3.9985 T305A,T306A None None XRAY 1.95 0.206 0.247 B 317.0 303.0 0 28 28 0 [[13, 271]] 1.0 7b57 Mus musculus CAMK_CAMK2A_MOUSE CAMK 1.7e-96 328.6 1.0 256.0 256.0 155 156 157 159 161 42 60 64 132 134 133 135.0 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CK1 CSNK1D KC1D_MOUSE 5X17A Q9DC28 3 292 415.0 ADP:307 Type1.5_Back Active DFGin 5.8854 15.0171 BLAminus -136.76, 176.51 70.17, 78.89 -96.78, 24.57 288.71, 93.09 -76.8, -15.99 in-in in 8.1025 Saltbr-in 3.1483 HRD-in -73.34, -55.18 81.19, 1.41 in-in-in SNCiii in-in ActLoopNT-in 2.8237 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -69.47, -59.72 APE9-dihe-na -86.86, -154.47 APE8-dihe-in -76.87, 120.04 APE8-rot-in 308.55 APE67-dihe-in -51.63, -37.36 -55.73, -38.13 APE12-dist-in 10.4574 APE11-dist-in 12.4167 APE10-dist-in 6.3785 APE9-dist-in 3.8068 None None None XRAY 2.0 0.19 0.242 A 296.0 290.0 0 35 35 0 [[9, 275]] 1.0 5x17 Mus musculus CK1_CSNK1D_MOUSE CK1 1.6e-122 413.9 1.0 262.0 262.0 148 149 150 152 154 38 52 56 125 127 126 128.0 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_MOUSE 5X17B Q9DC28 4 292 415.0 ADP:306 Type1.5_Back Active DFGin 6.3327 14.9893 BLAminus -121.28, -179.96 69.25, 82.44 -101.59, 21.98 290.59, 89.01 -77.86, -17.5 in-in in 8.0416 Saltbr-in 3.1065 HRD-in -90.58, -48.35 72.79, 12.65 in-in-in SNCiii in-in ActLoopNT-in 2.7599 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.44, 137.77 APE9-dihe-na 91.26, -171.32 APE8-dihe-in -91.08, 137.89 APE8-rot-in 301.79 APE67-dihe-in -58.2, -31.0 -69.62, -39.78 APE12-dist-in 12.2973 APE11-dist-in 11.9873 APE10-dist-in 6.4915 APE9-dist-in 3.3728 None None None XRAY 2.0 0.19 0.242 B 296.0 289.0 0 35 35 0 [[9, 275]] 1.0 5x17 Mus musculus CK1_CSNK1D_MOUSE CK1 1.6e-122 413.9 1.0 262.0 262.0 148 149 150 152 154 38 52 56 125 127 126 128.0 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CMGC GSK3B GSK3B_MOUSE 8VMFA Q9WV60 27 383 420.0 ADP:60504 ATPlike Active DFGin 6.6121 14.0996 BLAminus -148.4, -167.57 58.53, 66.72 -90.57, 24.21 287.49, 78.37 -75.04, -7.89 in-in in 8.6601 Saltbr-in 2.678 HRD-in -67.34, -47.3 70.6, 6.45 in-in-in SNCiii in-in ActLoopNT-in 2.8401 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -98.01, -20.74 APE9-dihe-na -93.16, -168.14 APE8-dihe-in -112.8, 164.36 APE8-rot-in 304.6 APE67-dihe-inflip 78.98, -8.38 -56.8, 140.56 APE12-dist-in 13.183 APE11-dist-in 10.9487 APE10-dist-in 6.514 APE9-dist-in 3.3085 None None None XRAY 2.5 0.21 0.251 A 364.0 354.0 0 27 27 0 [[56, 340]] 1.0 8vmf Mus musculus CMGC_GSK3B_MOUSE CMGC 2e-70 243.5 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_MOUSE 8VMGA Q9WV60 26 383 420.0 ADP:60401 ATPlike Active DFGin 7.0002 13.9987 BLAminus -139.67, -176.86 60.44, 73.06 -89.27, 27.07 283.1, 81.19 -73.23, -12.63 in-in in 8.478 Saltbr-in 2.6881 HRD-in -67.64, -48.38 72.75, 3.36 in-in-in SNCiii in-in ActLoopNT-in 2.8435 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.26, 164.63 APE9-dihe-na 72.45, 142.8 APE8-dihe-in -66.41, 146.08 APE8-rot-in 307.07 APE67-dihe-in -64.3, -22.81 -57.43, -46.54 APE12-dist-in 13.2782 APE11-dist-in 11.627 APE10-dist-in 6.9412 APE9-dist-in 2.9838 None None None XRAY 2.45 0.195 0.23 A 364.0 358.0 0 27 27 0 [[56, 340]] 1.0 8vmg Mus musculus CMGC_GSK3B_MOUSE CMGC 2e-70 243.5 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_MOUSE 8VMEA Q9WV60 26 383 420.0 ADP:60401 ATPlike Active DFGin 6.469 13.8439 BLAminus -131.0, -171.33 63.41, 73.0 -92.56, 22.88 289.27, 83.61 -79.03, -1.02 in-in in 8.7532 Saltbr-in 2.7802 HRD-in -67.9, -47.67 70.4, 7.52 in-in-in SNCiii in-in ActLoopNT-in 2.7313 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.18, 168.01 APE9-dihe-na 68.83, 161.19 APE8-dihe-in -90.7, 152.54 APE8-rot-in 290.93 APE67-dihe-inflip 82.32, -22.26 -51.38, 150.9 APE12-dist-in 13.2878 APE11-dist-in 12.0712 APE10-dist-in 6.9342 APE9-dist-in 3.2916 None None None XRAY 2.3 0.183 0.23 A 365.0 355.0 0 27 27 0 [[56, 340]] 1.0 8vme Mus musculus CMGC_GSK3B_MOUSE CMGC 2.1e-70 243.5 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_MOUSE 4NU1A Q9WV60 6 383 420.0 ADP:405 ATPlike Active DFGin 6.1094 13.6771 BLAminus -140.27, -172.8 60.29, 88.19 -108.14, 24.39 289.57, 88.21 -68.01, -14.99 in-in in 8.691 Saltbr-in 2.7928 HRD-in -66.76, -45.51 62.96, 19.85 in-in-in SNCiii in-in ActLoopNT-in 2.6824 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.38, 172.68 APE9-dihe-na 66.76, 153.81 APE8-dihe-in -82.08, 156.46 APE8-rot-in 299.93 APE67-dihe-inflip 76.53, -25.22 -54.39, 158.45 APE12-dist-in 13.5101 APE11-dist-in 11.6207 APE10-dist-in 7.1263 APE9-dist-in 3.1496 None SEP9 SEP9 XRAY 2.5 0.194 0.245 A 389.0 357.0 2 27 27 0 [[56, 340]] 1.0 4nu1 Mus musculus CMGC_GSK3B_MOUSE CMGC 2.5e-70 243.2 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
OTHER ERN1 ERN1_MOUSE 4PL4B Q9EQY0 562 963 977.0 ADP:1001 ATPlike Inactive DFGin 7.3927 13.4972 BLBplus -131.17, -171.5 49.73, 22.15 -77.96, 172.77 53.0, 89.01 68.36, -18.97 out-out out 16.1855 Saltbr-out 12.8674 HRD-in -71.43, -56.11 80.63, -15.27 out-out-out SNCooo out-out ActLoopNT-out 10.3004 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -71.5, 161.7 APE9-dihe-na 95.56, 170.85 APE8-dihe-in -126.15, 140.57 APE8-rot-in 313.23 APE67-dihe-inflip 115.41, -9.81 -59.18, 119.64 APE12-dist-none 999.0 APE11-dist-in 13.3728 APE10-dist-out 8.9632 APE9-dist-in 3.3017 N772Y None None XRAY 3.0 0.213 0.276 B 435.0 384.0 18 31 19 12 [[571, 832]] 1.0 4pl4 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL4C Q9EQY0 562 963 977.0 ADP:1001 ATPlike Inactive DFGin 7.5482 14.2484 BLBplus -126.51, -173.84 57.1, 11.03 -79.33, 148.55 56.35, 128.67 90.22, -11.73 out-out out 16.9717 Saltbr-out 13.4493 HRD-in -87.09, -33.21 64.61, -28.11 out-out-out SNCooo out-out ActLoopNT-out 10.6681 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioi APE10-dihe-na -75.07, 168.04 APE9-dihe-na 83.31, 160.45 APE8-dihe-in -117.06, 150.3 APE8-rot-out 84.63 APE67-dihe-inflip 114.33, -11.46 -59.41, 124.52 APE12-dist-none 999.0 APE11-dist-in 13.4836 APE10-dist-out 8.4493 APE9-dist-in 3.5542 N772Y None None XRAY 3.0 0.213 0.276 C 435.0 384.0 18 31 19 12 [[571, 832]] 1.0 4pl4 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL4D Q9EQY0 562 961 977.0 ADP:1001 ATPlike Inactive DFGin 7.5079 13.71 BLBplus -135.47, -173.14 51.5, 21.77 -87.04, 144.38 56.66, 114.14 91.93, -17.13 out-out out 15.9791 Saltbr-out 13.3396 HRD-in -83.86, -32.09 72.35, -48.88 out-out-out SNCooo out-out ActLoopNT-out 10.328 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -70.73, 154.49 APE9-dihe-na 96.39, -168.63 APE8-dihe-in -140.56, 130.56 APE8-rot-in 311.25 APE67-dihe-inflip 116.72, -15.16 -51.06, 117.77 APE12-dist-none 999.0 APE11-dist-in 13.9703 APE10-dist-out 9.1376 APE9-dist-in 3.9224 N772Y None None XRAY 3.0 0.213 0.276 D 435.0 377.0 18 31 19 12 [[571, 832]] 1.0 4pl4 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL5B Q9EQY0 562 963 977.0 ADP:1001 ATPlike Inactive DFGin 7.4546 13.9365 BLBplus -129.37, -173.23 56.7, 18.18 -83.15, 166.18 46.51, 88.1 78.73, -17.65 out-out out 17.3785 Saltbr-out 14.0508 HRD-in -57.7, -43.88 69.49, -15.96 out-out-out SNCooo out-out ActLoopNT-out 10.0479 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nioi APE10-dihe-na -68.77, 169.09 APE9-dihe-na 94.26, -167.14 APE8-dihe-in -147.72, 134.59 APE8-rot-in 292.91 APE67-dihe-out 142.49, -27.58 -41.24, 92.94 APE12-dist-none 999.0 APE11-dist-in 13.2922 APE10-dist-out 8.4459 APE9-dist-in 3.3559 N772Y None None XRAY 3.4 0.225 0.285 B 435.0 383.0 19 31 18 13 [[571, 832]] 1.0 4pl5 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL5C Q9EQY0 562 963 977.0 ADP:1001 ATPlike Inactive DFGin 7.7942 14.0613 BLBplus -140.3, -178.86 59.78, 31.79 -102.25, 171.48 50.28, 80.31 73.36, 0.55 out-out out 16.8522 Saltbr-out 12.6343 HRD-in -71.26, -29.05 67.43, -40.0 out-out-out SNCooo out-out ActLoopNT-out 10.5425 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -68.61, -176.62 APE9-dihe-na 79.33, -164.24 APE8-dihe-in -141.99, 145.59 APE8-rot-in 309.7 APE67-dihe-inflip 125.8, -7.43 -55.77, 102.3 APE12-dist-none 999.0 APE11-dist-in 13.6845 APE10-dist-out 8.5993 APE9-dist-in 3.6488 N772Y None None XRAY 3.4 0.225 0.285 C 435.0 386.0 16 31 20 11 [[571, 832]] 1.0 4pl5 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL5D Q9EQY0 561 963 977.0 ADP:1001 ATPlike Inactive DFGin 6.8833 13.7093 BLBplus -149.88, 177.73 60.77, 34.53 -99.83, 170.66 50.74, 82.52 85.0, -30.32 out-out out 16.8731 Saltbr-out 16.3097 HRD-in -73.87, -31.52 63.42, -30.41 out-out-out SNCooo out-out ActLoopNT-out 10.8618 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioi APE10-dihe-na -64.48, 167.99 APE9-dihe-na 99.63, 173.49 APE8-dihe-in -124.29, 140.67 APE8-rot-out 174.47 APE67-dihe-inflip 122.64, -17.06 -61.26, 114.95 APE12-dist-none 999.0 APE11-dist-in 13.2318 APE10-dist-out 8.1121 APE9-dist-in 3.9187 N772Y None None XRAY 3.4 0.225 0.285 D 435.0 385.0 18 31 19 12 [[571, 832]] 1.0 4pl5 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL3A Q9EQY0 560 964 977.0 31J:1001,ADP:1002 Allosteric,ATPlike Inactive DFGin 7.327 13.7163 BLBplus -137.83, -169.53 45.26, 38.38 -99.01, 160.39 56.61, 78.79 64.67, 4.33 out-out out 16.5791 Saltbr-out 12.4483 HRD-in -67.88, -49.57 75.5, 1.96 out-out-out SNCooo out-out ActLoopNT-out 9.693 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -56.59, -179.83 APE9-dihe-na 70.82, 169.1 APE8-dihe-in -122.85, 127.5 APE8-rot-in 297.91 APE67-dihe-inflip 117.64, -32.26 -39.31, 118.58 APE12-dist-none 999.0 APE11-dist-out 14.0611 APE10-dist-out 9.3121 APE9-dist-in 3.5586 N772Y None None XRAY 2.9 0.202 0.234 A 435.0 388.0 17 31 19 12 [[571, 832]] 1.0 4pl3 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL3B Q9EQY0 562 963 977.0 31J:1001,ADP:1002 Allosteric,ATPlike Inactive DFGin 7.3343 13.8933 BLBplus -148.72, -173.45 55.21, 14.76 -81.6, 169.54 60.69, 84.7 79.59, -5.1 out-out out 16.5804 Saltbr-out 13.2885 HRD-in -77.64, -56.6 82.71, -30.85 out-out-out SNCooo out-out ActLoopNT-out 10.6216 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -64.56, 166.09 APE9-dihe-na 91.33, -176.0 APE8-dihe-in -135.33, 135.79 APE8-rot-in 299.82 APE67-dihe-inflip 121.38, -25.98 -48.92, 119.9 APE12-dist-none 999.0 APE11-dist-out 14.1225 APE10-dist-out 9.3359 APE9-dist-in 3.6949 N772Y None None XRAY 2.9 0.202 0.234 B 435.0 383.0 19 31 18 13 [[571, 832]] 1.0 4pl3 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL4A Q9EQY0 562 963 977.0 31K:1001,ADP:1002 Allosteric,ATPlike Inactive DFGin 6.7883 14.2186 BLBplus -105.14, -174.11 44.38, 29.11 -94.38, 143.46 69.8, 104.54 103.76, -33.08 out-out out 16.6052 Saltbr-out 13.2732 HRD-in -77.26, -47.59 71.94, -10.31 out-out-out SNCooo out-out ActLoopNT-out 10.5629 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -61.91, 153.92 APE9-dihe-na 102.53, -174.53 APE8-dihe-in -133.87, 129.13 APE8-rot-in 297.04 APE67-dihe-inflip 119.89, -24.27 -52.28, 118.86 APE12-dist-none 999.0 APE11-dist-out 14.3788 APE10-dist-out 9.4324 APE9-dist-in 3.2964 N772Y None None XRAY 3.0 0.213 0.276 A 435.0 385.0 17 31 20 11 [[571, 832]] 1.0 4pl4 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL5A Q9EQY0 562 964 977.0 31L:1001,ADP:1002,PEU:1004 Allosteric,ATPlike,Allosteric Inactive DFGin 6.5845 13.7552 BLBplus -127.28, -167.94 47.08, 28.46 -89.65, 160.5 62.46, 164.78 70.79, 0.93 out-out out 16.2962 Saltbr-out 12.729 HRD-in -75.22, -42.28 71.55, -19.88 out-out-out SNCooo out-out ActLoopNT-out 10.4865 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -69.09, -179.67 APE9-dihe-na 72.79, -173.9 APE8-dihe-in -128.85, 142.84 APE8-rot-in 291.98 APE67-dihe-inflip 114.76, -25.15 -48.2, 123.54 APE12-dist-none 999.0 APE11-dist-in 13.7986 APE10-dist-out 8.5968 APE9-dist-in 3.4978 N772Y None None XRAY 3.4 0.225 0.285 A 435.0 386.0 17 31 19 12 [[571, 832]] 1.0 4pl5 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
TYR EPHB2 EPHB2_MOUSE 2HENA P54763 614 893 986.0 ADP:60400 ATPlike None DFGin 5.3332 15.674 BLAminus -133.74, -165.91 59.29, 70.83 -103.82, 9.51 292.63, 82.7 -87.21, 999.0 in-in in 8.0233 Saltbr-in 2.7858 HRD-in -62.88, -49.36 74.49, -21.92 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 78.77 APE8-rot-na 327.53 APE67-dihe-in -57.52, -8.41 -44.64, -64.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 D746A None None XRAY 2.6 0.205 0.26 A 286.0 258.0 22 33 11 22 [[621, 882]] 1.0 2hen Mus musculus TYR_EPHB2_MOUSE TYR 7e-108 365.8 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR EPHB2 EPHB2_MOUSE 2HENB P54763 614 893 986.0 ADP:60401 ATPlike None DFGin 4.8756 14.8878 BLAminus -140.27, -169.83 69.21, 92.69 -125.5, 35.8 302.49, 84.21 -59.5, 999.0 in-in in 8.2673 Saltbr-in 2.8391 HRD-in -71.96, -52.85 76.51, -19.64 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 70.95 APE8-rot-na 35.68 APE67-dihe-in -63.04, 8.29 -53.0, -58.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 D746A None None XRAY 2.6 0.205 0.26 B 286.0 258.0 22 33 11 22 [[621, 882]] 1.0 2hen Mus musculus TYR_EPHB2_MOUSE TYR 7e-108 365.8 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR EPHB2 EPHB2_MOUSE 2HENC P54763 614 893 986.0 ADP:60402 ATPlike None DFGin 5.1672 15.7873 BLAminus -136.6, -161.63 61.14, 70.93 -108.31, 8.65 286.35, 98.46 -79.82, 999.0 in-in in 8.0738 Saltbr-in 2.8762 HRD-in -60.04, -43.18 71.33, -24.11 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 75.37 APE8-rot-na 329.62 APE67-dihe-in -67.84, -7.2 -58.96, -40.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 D746A None None XRAY 2.6 0.205 0.26 C 286.0 258.0 22 33 11 22 [[621, 882]] 1.0 2hen Mus musculus TYR_EPHB2_MOUSE TYR 7e-108 365.8 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR EPHB2 EPHB2_MOUSE 2HEND P54763 614 893 986.0 ADP:60403 ATPlike None DFGin 4.7905 14.7722 BLAminus -150.33, -176.71 75.96, 94.04 -126.18, 89.85 307.58, 79.07 -67.67, 999.0 in-in in 8.3217 Saltbr-in 3.4086 HRD-in -71.43, -49.79 75.74, -24.02 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 92.49 APE8-rot-na 333.13 APE67-dihe-in -68.61, 6.13 -48.05, -54.94 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 D746A None None XRAY 2.6 0.205 0.26 D 286.0 258.0 22 33 11 22 [[621, 882]] 1.0 2hen Mus musculus TYR_EPHB2_MOUSE TYR 7e-108 365.8 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR JAK1-12 JAK1_MOUSE 7T6FA P52332 32 1153 1153.0 ADN:61201,ADP:61202 Allosteric,ATPlike Inactive DFGin 6.8989 13.8131 None -86.13, -125.98 -78.37, 170.67 -132.74, 42.36 300.4, 95.7 -63.52, -44.16 in-out in 8.2656 Saltbr-out 5.3454 HRD-in -74.55, -24.53 68.9, -7.15 out-in-out SNCoio in-out ActLoopNT-in 3.3664 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -74.97, -30.61 APE9-dihe-in -69.86, 145.09 APE8-dihe-in -65.5, 154.45 APE8-rot-na 337.81 APE67-dihe-in -111.81, 34.03 -69.03, -47.03 APE12-dist-na 13.0701 APE11-dist-na 13.989 APE10-dist-na 8.6737 APE9-dist-in 6.36 None None None EM 3.6 999.0 999.0 A 1173.0 1043.0 23 31 31 0 [[582, 846], [874, 1150]] 2.0 7t6f Mus musculus TYR_JAK1-12_MOUSE TYR 7.5e-59 499.6 3.0 260.0 516.0 1019 1020 1021 1023 1025 907 924 928 999 1001 1000 1002.0 1062 1050 1045 1044 1043 1042 1041 1040 1039 956 Tyrosine-protein kinase JAK1
TYR JAK1-12 JAK1_MOUSE 7T6FB P52332 32 1153 1153.0 ADN:61201,ADP:61202 Allosteric,ATPlike Inactive DFGin 6.8984 13.8132 None -86.09, -125.95 -78.45, 170.72 -132.73, 42.29 300.45, 95.61 -63.42, -44.2 in-out in 8.2667 Saltbr-out 5.3471 HRD-in -74.65, -24.42 68.9, -7.11 out-in-out SNCoio in-out ActLoopNT-in 3.3661 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -74.91, -30.65 APE9-dihe-in -69.79, 145.09 APE8-dihe-in -65.5, 154.47 APE8-rot-na 337.81 APE67-dihe-in -111.9, 34.05 -69.03, -46.98 APE12-dist-na 13.0694 APE11-dist-na 13.9887 APE10-dist-na 8.6729 APE9-dist-in 6.3604 None None None EM 3.6 999.0 999.0 B 1173.0 1043.0 23 31 31 0 [[582, 846], [874, 1150]] 2.0 7t6f Mus musculus TYR_JAK1-12_MOUSE TYR 7.5e-59 499.6 3.0 260.0 516.0 1019 1020 1021 1023 1025 907 924 928 999 1001 1000 1002.0 1062 1050 1045 1044 1043 1042 1041 1040 1039 956 Tyrosine-protein kinase JAK1
TYR JAK1-12 JAK1_MOUSE 8EWYA P52332 32 1153 1153.0 ADN:61201,ADP:61202 Allosteric,ATPlike Inactive None 999.0 999.0 None -138.68, -158.74 57.84, 53.41 -86.5, 17.2 999.0, 999.0 -66.33, -21.83 in-none in 8.0785 Saltbr-none 999.0 HRD-in -63.86, -38.24 65.99, -1.42 none-in-in SNCnii in-in ActLoopNT-in 2.8414 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.88, 139.03 APE9-dihe-in -137.63, 148.1 APE8-dihe-in -70.82, 80.23 APE8-rot-na 999.0 APE67-dihe-in -71.32, -12.38 -60.07, -30.97 APE12-dist-na 13.0021 APE11-dist-na 7.9281 APE10-dist-na 11.009 APE9-dist-in 6.3419 V657F None None EM 5.5 999.0 999.0 A 1173.0 1047.0 19 31 31 0 [[582, 846], [874, 1150]] 2.0 8ewy Mus musculus TYR_JAK1-12_MOUSE TYR 7.5e-59 499.6 3.0 260.0 516.0 1019 1020 1021 1023 1025 907 924 928 999 1001 1000 1002.0 1062 1050 1045 1044 1043 1042 1041 1040 1039 956 Tyrosine-protein kinase JAK1
TYR JAK1-12 JAK1_MOUSE 8EWYB P52332 32 1153 1153.0 ADN:61201,ADP:61202 Allosteric,ATPlike Inactive None 999.0 999.0 None -138.65, -158.76 57.86, 53.37 -86.37, 17.05 999.0, 999.0 -66.24, -21.9 in-none in 8.0788 Saltbr-none 999.0 HRD-in -63.87, -38.25 66.06, -1.5 none-in-in SNCnii in-in ActLoopNT-in 2.8419 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.87, 139.06 APE9-dihe-in -137.62, 148.16 APE8-dihe-in -70.91, 80.26 APE8-rot-na 999.0 APE67-dihe-in -71.25, -12.38 -60.08, -31.01 APE12-dist-na 13.0021 APE11-dist-na 7.9285 APE10-dist-na 11.0086 APE9-dist-in 6.3412 V657F None None EM 5.5 999.0 999.0 B 1173.0 1047.0 19 31 31 0 [[582, 846], [874, 1150]] 2.0 8ewy Mus musculus TYR_JAK1-12_MOUSE TYR 7.5e-59 499.6 3.0 260.0 516.0 1019 1020 1021 1023 1025 907 924 928 999 1001 1000 1002.0 1062 1050 1045 1044 1043 1042 1041 1040 1039 956 Tyrosine-protein kinase JAK1
TYR SRC SRC_MOUSE 8XN8A P05480 85 534 535.0 ADP:601 ATPlike Inactive DFGin 5.8276 13.2331 BLBplus -120.06, 161.26 65.68, 32.74 -74.22, 143.59 39.08, 88.47 84.86, -35.8 out-out out 13.9863 Saltbr-out 13.9219 HRD-in -73.69, -59.12 84.41, -7.57 out-out-out SNCooo out-out ActLoopNT-out 7.4048 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.24, -6.02 APE9-dihe-in -94.54, 127.69 APE8-dihe-in -80.44, 65.55 APE8-rot-na 33.74 APE67-dihe-in -67.14, -17.8 -57.51, -33.8 APE12-dist-na 17.6986 APE11-dist-na 18.5584 APE10-dist-na 13.3733 APE9-dist-out 8.7101 None PTR529 PTR529 XRAY 1.95 0.187 0.224 A 451.0 450.0 0 29 29 0 [[269, 520]] 1.0 8xn8 Mus musculus TYR_SRC_MOUSE TYR 8.8e-94 319.8 1.0 260.0 260.0 405 406 407 409 411 297 312 316 385 387 386 388.0 446 434 429 428 427 426 425 424 423 341 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_MOUSE 6F3FA P05480 85 531 535.0 ADP:60601 ATPlike Inactive DFGin 5.729 13.2626 BLBplus -129.36, 166.09 58.36, 35.58 -80.98, 135.75 39.82, 82.45 82.86, -9.54 out-out out 14.175 Saltbr-out 14.398 HRD-in -79.21, -57.39 83.57, -8.9 out-out-out SNCooo out-out ActLoopNT-out 7.2896 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -111.04, 2.76 APE9-dihe-in -98.67, 129.97 APE8-dihe-in -74.19, 70.52 APE8-rot-na 30.31 APE67-dihe-in -76.25, -9.79 -62.62, -30.23 APE12-dist-na 17.5264 APE11-dist-na 18.7227 APE10-dist-na 13.526 APE9-dist-out 8.5478 None PTR529 PTR529 XRAY 2.418 0.211 0.268 A 455.0 447.0 0 29 29 0 [[269, 520]] 1.0 6f3f Mus musculus TYR_SRC_MOUSE TYR 9e-94 319.7 1.0 260.0 260.0 405 406 407 409 411 297 312 316 385 387 386 388.0 446 434 429 428 427 426 425 424 423 341 Proto-oncogene tyrosine-protein kinase Src
OTHER PKNB PKNB_MYCTU 3F61A P9WI81 1 290 626.0 ADP:340 ATPlike Inactive DFGin 10.4084 16.8235 BLBminus -141.07, 168.15 65.97, 58.12 -87.1, 145.62 281.84, 72.93 89.1, 11.07 in-out in 9.9329 Saltbr-out 6.7775 HRD-in -66.51, -54.56 82.27, -14.45 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -63.4, -20.65 999.0, 0.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 L33D,V222D None None XRAY 1.8 0.205 0.228 A 311.0 271.0 19 31 12 19 [[11, 273]] 1.0 3f61 Mycobacterium tuberculosis OTHER_PKNB_MYCTU CAMK 1.6e-46 164.7 1.0 248.0 248.0 155 156 157 159 161 40 59 63 135 137 136 138.0 198 186 181 180 179 178 177 176 175 93 Serine/threonine-protein kinase PknB
OTHER PKNG PKNG_MYCTU 4Y0XA P9WI73 83 404 750.0 ADP:501 ATPlike Inactive DFGin 6.7267 11.5343 BLAminus -117.75, -169.01 53.44, 71.03 -83.15, 12.14 305.33, 8.75 -59.16, -32.06 out-out out 15.116 Saltbr-out 15.0592 HRD-in -73.44, -41.15 68.04, -13.32 out-in-out SNCoio in-out ActLoopNT-in 2.7773 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -55.23, 147.28 APE9-dihe-na -174.26, 176.21 APE8-dihe-in -98.04, 125.35 APE8-rot-in 298.01 APE67-dihe-inflip 105.55, -13.26 -56.87, 129.33 APE12-dist-out 5.5418 APE11-dist-in 10.1536 APE10-dist-in 7.3709 APE9-dist-in 5.7905 None None None XRAY 1.74 0.198 0.209 A 375.0 322.0 0 24 24 0 [[151, 345]] 1.0 4y0x Mycobacterium tuberculosis OTHER_PKNG_MYCTU CAMK 8.2e-22 86.0 1.0 186.0 186.0 292 293 294 296 298 181 198 202 273 275 274 276.0 327 316 311 310 309 308 307 306 305 233 Serine/threonine-protein kinase PknG
OTHER PKNI PKNI_MYCTU 5M06B P9WI69 2 255 585.0 ADP:301 ATPlike Inactive DFGin 8.3159 16.6312 BLBminus -112.52, 166.29 60.43, 51.53 -60.28, 125.48 270.62, 84.02 56.24, 31.01 out-out out 14.989 Saltbr-out 14.3942 HRD-in -80.29, -52.43 77.96, -9.32 out-out-out SNCooo out-out ActLoopNT-out 11.5297 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-out -70.34, -46.82 -66.42, 150.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.213 0.239 B 276.0 248.0 3 14 14 0 [[12, 175]] 1.0 5m06 Mycobacterium tuberculosis OTHER_PKNI_MYCTU CAMK 1.3e-18 76.4 1.0 201.0 201.0 158 159 160 162 164 41 60 64 134 136 135 137.0 184 172 167 166 0 0 0 0 0 90 Serine/threonine-protein kinase PknI
STE MAP2K1 MP2K1_RABIT 7JUQC P29678 40 381 393.0 ADP:401 ATPlike Inactive DFGin 6.5861 14.742 BLBplus -129.84, -170.1 45.36, 32.9 -86.02, 164.53 43.64, 99.66 -81.97, 72.94 out-out out 15.5727 Saltbr-out 14.6393 HRD-in -71.73, -54.6 83.98, -10.27 out-out-out SNCooo out-out ActLoopNT-out 9.8167 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -103.97, 121.68 APE9-dihe-na -107.28, -138.86 APE8-dihe-out -101.2, -25.18 APE8-rot-out 36.43 APE67-dihe-out -125.05, 133.16 -97.84, 131.49 APE12-dist-out 16.4657 APE11-dist-out 18.834 APE10-dist-out 20.472 APE9-dist-out 14.6884 None None None XRAY 3.22 0.256 0.288 C 384.0 305.0 37 26 26 0 [[68, 361]] 1.0 7juq Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
OTHER FLS2 FLS2_ORYSJ 8JUVA Q0JA29 861 1178 1183.0 ADP:60601 ATPlike Inactive DFGin 6.1498 14.3273 BLAminus -130.59, 177.4 65.69, 86.01 -100.39, 23.88 290.69, 79.09 -65.0, -14.14 in-in in 8.0252 Saltbr-in 2.7601 HRD-in -70.78, -47.74 78.11, -0.08 in-in-out SNCiio in-out ActLoopNT-in 2.7474 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -103.82, 168.59 APE9-dihe-na 62.78, -132.62 APE8-dihe-out -74.57, -16.63 APE8-rot-out 44.07 APE67-dihe-in -63.03, -19.63 -66.3, -33.92 APE12-dist-out 23.7254 APE11-dist-out 18.6911 APE10-dist-out 19.68 APE9-dist-out 12.2555 None None MSE903,MSE959,MSE1037,MSE1066,MSE1073,MSE1090,MSE1134,MSE1166,MSE1176 XRAY 2.09 0.183 0.208 A 339.0 288.0 30 39 23 16 [[874, 1175]] 1.0 8juv Oryza sativa OTHER_FLS2_ORYSJ TKL 3.7e-44 157.3 4.0 265.0 262.0 1030 1031 1032 1034 1036 908 926 930 1010 1012 1011 1013.0 1081 1069 1064 1063 1062 1061 1060 1059 1058 957 LRR receptor-like serine/threonine-protein kinase FLS2
OTHER PINK1 PINK1_PEDHC 8UYIA E0W1I1 120 572 575.0 ADP:601 ATPlike Active DFGin 9.4715 14.4921 BLAminus -126.54, -170.24 58.08, 66.04 -87.71, 25.91 289.34, 85.25 -66.89, -21.8 in-in in 7.7338 Saltbr-in 2.4889 HRD-in -72.82, -45.28 62.7, 4.34 in-in-in SNCiii in-in ActLoopNT-in 2.7928 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na 149.48, -127.57 APE9-dihe-na -109.63, -105.35 APE8-dihe-in -70.24, 160.24 APE8-rot-na 51.46 APE67-dihe-in -90.34, -42.74 -107.64, 8.21 APE12-dist-in 8.4846 APE11-dist-in 10.4134 APE10-dist-in 5.8277 APE9-dist-in 3.6425 None SEP202,TPO305 SEP202,TPO305 EM 3.13 999.0 999.0 A 463.0 369.0 49 34 34 0 [[64, 514]] 1.0 8uyi Pediculus humanus OTHER_PINK1_PEDHC PINK1 1e-86 297.1 4.0 367.0 364.0 356 357 358 360 362 193 214 218 331 333 332 334.0 408 390 385 384 383 382 381 380 379 291 Serine/threonine-protein kinase Pink1, mitochondrial
OTHER PINK1 PINK1_PEDHC 8UYIB E0W1I1 122 574 575.0 ADP:601 ATPlike Active DFGin 9.3699 14.7672 BLAminus -128.32, -168.79 58.11, 64.54 -83.54, 12.33 278.78, 92.3 -66.63, -13.93 in-in in 8.0008 Saltbr-in 2.3626 HRD-in -66.42, -44.15 62.85, 2.17 in-in-in SNCiii in-in ActLoopNT-in 2.9742 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na 143.29, -143.85 APE9-dihe-na -111.19, -100.88 APE8-dihe-in -71.36, 134.31 APE8-rot-na 50.34 APE67-dihe-in -67.38, -41.28 -74.79, -24.08 APE12-dist-in 8.4735 APE11-dist-in 10.8064 APE10-dist-in 6.2268 APE9-dist-in 3.5529 None SEP202,TPO305 SEP202,TPO305 EM 3.13 999.0 999.0 B 463.0 369.0 51 34 34 0 [[64, 514]] 1.0 8uyi Pediculus humanus OTHER_PINK1_PEDHC PINK1 1e-86 297.1 4.0 367.0 364.0 356 357 358 360 362 193 214 218 331 333 332 334.0 408 390 385 384 383 382 381 380 379 291 Serine/threonine-protein kinase Pink1, mitochondrial
AGC PRKACA KAPCA_RAT 3TNQB P27791 18 351 351.0 ADP:60400 ATPlike Inactive DFGin 6.0256 14.1092 ABAminus -114.77, -42.68 -116.73, 98.61 -86.63, 16.07 279.08, 57.74 -59.27, -13.09 in-in in 8.7647 Saltbr-in 3.2951 HRD-in -83.62, -53.15 67.05, 14.07 in-in-in SNCiii in-in ActLoopNT-in 3.0146 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.54, 167.18 APE9-dihe-na 139.44, -131.54 APE8-dihe-in -144.99, 127.08 APE8-rot-in 312.05 APE67-dihe-in -55.59, -13.34 -44.48, -54.97 APE12-dist-in 8.0951 APE11-dist-in 11.4567 APE10-dist-in 6.1812 APE9-dist-in 3.5888 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 3.097 0.234 0.275 B 350.0 334.0 0 25 25 0 [[44, 298]] 1.0 3tnq Rattus norvegicus AGC_PRKACA_RAT AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CMGC MAPK1 MK01_RAT 4GVAA P63086 11 356 358.0 ADP:401 ATPlike Inactive DFGin 6.7023 16.7688 BLAminus -137.11, 178.59 63.89, 77.38 -94.14, 25.17 286.58, 79.57 -59.17, -35.22 out-out out 10.4922 Saltbr-out 6.5214 HRD-in -67.64, -55.15 72.72, 9.25 out-in-in SNCoii in-in ActLoopNT-in 2.8301 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.68, -13.3 APE9-dihe-na -77.88, 161.53 APE8-dihe-in -56.04, 126.28 APE8-rot-in 320.84 APE67-dihe-in -66.77, -13.08 -47.2, -54.23 APE12-dist-in 13.8449 APE11-dist-in 11.0504 APE10-dist-in 7.1482 APE9-dist-in 4.1983 None None CME159 XRAY 1.83 0.191 0.241 A 364.0 346.0 0 31 31 0 [[23, 311]] 1.0 4gva Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.4e-85 293.1 1.0 301.0 301.0 164 165 166 168 170 52 69 73 144 146 145 147.0 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC FUS3 FUS3_YEAST 2B9HA P16892 1 353 353.0 ADP:500 ATPlike Inactive DFGin 6.2831 13.7635 BLAminus -136.62, -177.7 68.6, 65.84 -94.91, 10.48 297.74, 102.72 -75.81, -10.99 in-in in 8.5638 Saltbr-in 2.7323 HRD-in -74.04, -48.55 74.11, -6.87 in-in-out SNCiio in-out ActLoopNT-in 2.9317 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -116.55, 132.5 APE9-dihe-na -63.29, 147.56 APE8-dihe-in -50.7, 127.74 APE8-rot-in 296.79 APE67-dihe-in -63.13, -20.59 -60.61, -24.81 APE12-dist-in 8.6053 APE11-dist-out 6.693 APE10-dist-out 9.8356 APE9-dist-in 4.7504 T180V,Y182F None None XRAY 1.55 0.187 0.216 A 353.0 337.0 16 38 22 16 [[13, 309]] 1.0 2b9h Saccharomyces cerevisiae CMGC_FUS3_YEAST CMGC 2.2e-73 253.2 3.0 301.0 299.0 154 155 156 158 160 42 59 63 134 136 135 137.0 205 192 187 186 185 184 183 182 181 94 Mitogen-activated protein kinase FUS3
CMGC FUS3 FUS3_YEAST 2B9IA P16892 1 353 353.0 ADP:500 ATPlike Inactive DFGin 6.3651 14.0664 BLAminus -135.63, 178.36 68.62, 72.5 -98.81, 8.36 296.13, 97.35 -58.15, -32.2 in-in in 8.7017 Saltbr-in 2.9495 HRD-in -67.33, -47.39 70.79, -9.55 in-in-out SNCiio in-out ActLoopNT-in 2.9537 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -112.27, 137.29 APE9-dihe-na -73.31, 133.1 APE8-dihe-in -36.03, 128.5 APE8-rot-in 289.53 APE67-dihe-in -68.8, -14.68 -68.0, -19.59 APE12-dist-in 8.9047 APE11-dist-out 6.5806 APE10-dist-out 9.9611 APE9-dist-in 4.5499 T180V,Y182F None None XRAY 2.5 0.202 0.279 A 353.0 338.0 15 38 23 15 [[13, 309]] 1.0 2b9i Saccharomyces cerevisiae CMGC_FUS3_YEAST CMGC 2.2e-73 253.2 3.0 301.0 299.0 154 155 156 158 160 42 59 63 134 136 135 137.0 205 192 187 186 185 184 183 182 181 94 Mitogen-activated protein kinase FUS3
CMGC FUS3 FUS3_YEAST 2B9JA P16892 1 353 353.0 ADP:500 ATPlike Inactive DFGin 6.5469 13.8678 BLAminus -134.9, -176.68 60.68, 67.3 -98.24, 14.73 302.06, 96.25 -69.67, -26.86 in-in in 8.7013 Saltbr-in 2.9604 HRD-in -72.32, -48.06 70.0, -6.29 in-in-out SNCiio in-out ActLoopNT-in 2.9661 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -102.32, 139.79 APE9-dihe-na -71.76, 150.07 APE8-dihe-in -56.91, 118.63 APE8-rot-in 300.43 APE67-dihe-in -59.09, -25.02 -50.5, -31.25 APE12-dist-in 8.8527 APE11-dist-out 6.5935 APE10-dist-out 10.0651 APE9-dist-in 4.7662 T180V,Y182F None None XRAY 2.3 0.196 0.263 A 353.0 337.0 16 38 22 16 [[13, 309]] 1.0 2b9j Saccharomyces cerevisiae CMGC_FUS3_YEAST CMGC 2.2e-73 253.2 3.0 301.0 299.0 154 155 156 158 160 42 59 63 134 136 135 137.0 205 192 187 186 185 184 183 182 181 94 Mitogen-activated protein kinase FUS3
CMGC FUS3 FUS3_YEAST 2B9FA P16892 1 353 353.0 ADP:500 ATPlike Inactive DFGin 6.3195 13.8141 BLAminus -136.19, -174.38 64.52, 61.38 -89.09, 7.19 299.63, 104.82 -67.16, -21.09 in-in in 8.6105 Saltbr-in 2.6835 HRD-in -75.04, -47.21 75.53, -13.96 in-in-out SNCiio in-out ActLoopNT-in 3.0448 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -129.66, 156.16 APE9-dihe-na -66.55, 158.23 APE8-dihe-in -56.07, 140.2 APE8-rot-in 288.73 APE67-dihe-in -58.7, -27.3 -59.52, -33.17 APE12-dist-in 8.6815 APE11-dist-out 5.7984 APE10-dist-out 8.5735 APE9-dist-in 4.0923 None None None XRAY 1.8 0.213 0.259 A 353.0 337.0 16 38 22 16 [[13, 309]] 1.0 2b9f Saccharomyces cerevisiae CMGC_FUS3_YEAST CMGC 5.2e-75 258.5 3.0 301.0 299.0 154 155 156 158 160 42 59 63 134 136 135 137.0 205 192 187 186 185 184 183 182 181 94 Mitogen-activated protein kinase FUS3
CMGC FUS3 FUS3_YEAST 2F9GA P16892 1 353 353.0 ADP:500 ATPlike None DFGin 6.6068 14.0327 BLAminus -131.87, -173.96 62.19, 67.37 -94.01, 7.54 292.42, 102.61 -61.43, -28.32 in-in in 8.7382 Saltbr-in 2.7662 HRD-in -77.05, -50.83 75.67, -3.23 in-in-none SNCiin in-none ActLoopNT-in 2.9552 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.43 APE8-rot-in 296.4 APE67-dihe-in -62.22, -26.66 -58.62, -16.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None PTR182 PTR182 XRAY 2.1 0.211 0.26 A 353.0 332.0 21 38 17 21 [[13, 309]] 1.0 2f9g Saccharomyces cerevisiae CMGC_FUS3_YEAST CMGC 5.2e-75 258.5 3.0 301.0 299.0 154 155 156 158 160 42 59 63 134 136 135 137.0 205 192 187 186 185 184 183 182 181 94 Mitogen-activated protein kinase FUS3
CMGC KIN28 KIN28_YEAST 6XI8A P06242 6 303 306.0 ADP:401 ATPlike Inactive DFGin 5.5015 15.4441 BLAminus -145.77, -169.62 57.83, 69.55 -84.3, 48.2 280.55, 74.99 -75.72, -28.64 in-out in 8.9518 Saltbr-out 3.667 HRD-out 58.01, 71.8 -89.69, 32.34 out-in-out SNCoio in-out ActLoopNT-in 2.7014 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -116.0, -16.75 APE9-dihe-na -128.02, 157.65 APE8-dihe-in -70.96, 169.95 APE8-rot-out 44.23 APE67-dihe-in -79.03, -7.97 -69.89, -44.72 APE12-dist-in 12.3867 APE11-dist-in 10.7044 APE10-dist-in 6.15 APE9-dist-in 3.4398 None TPO162 TPO162 EM 3.64 999.0 999.0 A 301.0 290.0 8 28 28 0 [[7, 290]] 1.0 6xi8 Saccharomyces cerevisiae CMGC_KIN28_YEAST CMGC 4.1e-70 242.3 1.0 301.0 301.0 146 147 148 150 152 36 54 58 126 128 127 129.0 187 174 169 168 167 166 165 164 163 84 Serine/threonine-protein kinase KIN28
CMGC KIN28 KIN28_YEAST 7KUEA P06242 6 303 306.0 ADP:401 ATPlike Inactive DFGin 5.5017 15.4445 BLAminus -145.81, -169.57 57.84, 69.51 -84.28, 48.19 280.53, 74.97 -75.72, -28.63 in-out in 8.9524 Saltbr-out 3.6675 HRD-out 58.03, 71.82 -89.76, 32.34 out-in-out SNCoio in-out ActLoopNT-in 2.7016 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -115.99, -16.84 APE9-dihe-na -127.96, 157.63 APE8-dihe-in -70.94, 169.94 APE8-rot-out 44.25 APE67-dihe-in -79.07, -7.97 -69.92, -44.62 APE12-dist-in 12.3861 APE11-dist-in 10.7049 APE10-dist-in 6.1497 APE9-dist-in 3.4396 None TPO162 TPO162 EM 3.5 999.0 999.0 A 306.0 290.0 8 28 28 0 [[7, 290]] 1.0 7kue Saccharomyces cerevisiae CMGC_KIN28_YEAST CMGC 4.4e-70 242.3 1.0 301.0 301.0 146 147 148 150 152 36 54 58 126 128 127 129.0 187 174 169 168 167 166 165 164 163 84 Serine/threonine-protein kinase KIN28
CMGC SKY1 SKY1_YEAST 1Q8YA Q03656 144 737 742.0 ADP:60810 ATPlike Active DFGin 5.5538 12.776 BLAminus -120.8, -179.55 50.32, 80.87 -92.72, 24.06 294.38, 19.86 -63.4, -18.16 in-in in 8.712 Saltbr-in 2.7404 HRD-in -75.73, -45.78 71.18, -6.61 in-in-in SNCiii in-in ActLoopNT-in 2.9649 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.41, 175.98 APE9-dihe-na 63.08, 152.12 APE8-dihe-in -90.87, 131.26 APE8-rot-in 290.95 APE67-dihe-in -56.18, -26.85 -9.03, -76.03 APE12-dist-in 12.5336 APE11-dist-in 10.4963 APE10-dist-in 7.5074 APE9-dist-in 2.9897 None None None XRAY 2.05 0.209 0.244 A 373.0 351.0 11 25 25 0 [[158, 706]] 1.0 1q8y Saccharomyces cerevisiae CMGC_SKY1_YEAST CMGC 8.8e-100 339.7 1.0 301.0 301.0 549 550 551 553 555 187 202 206 291 293 292 294.0 586 574 569 568 567 566 565 564 563 247 Serine/threonine-protein kinase SKY1
OTHER BUD32 BUD32_YEAST 4WW9A P53323 4 259 261.0 ADP:302 ATPlike Active DFGin 6.6178 15.2832 BLAminus -128.14, 172.87 62.95, 73.82 -100.2, 23.36 281.69, 91.54 -52.55, -36.42 in-in in 7.602 Saltbr-in 2.7444 HRD-in -80.98, -51.42 97.59, -12.36 in-in-na SNCiia in-na ActLoopNT-in 2.852 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -61.46, -46.34 APE9-dihe-na -60.52, -40.33 APE8-dihe-na -68.91, -38.47 APE8-rot-na 168.71 APE67-dihe-na -62.48, -38.16 -54.4, -51.68 APE12-dist-na 15.7325 APE11-dist-na 11.1786 APE10-dist-na 14.6865 APE9-dist-na 11.7341 None None None XRAY 1.951 0.18 0.209 A 261.0 238.0 20 23 23 0 [[17, 261]] 1.0 4ww9 Saccharomyces cerevisiae OTHER_BUD32_YEAST TP53RK 5e-44 156.6 8.0 224.0 217.0 181 182 183 185 187 52 76 80 158 160 159 161.0 198 204 199 198 197 196 195 194 193 107 EKC/KEOPS complex subunit BUD32
OTHER CDC7 CDC7_YEAST 7PT78 P06243 10 475 507.0 ADP:1001,BEF:1003 ATPlike,Allosteric Inactive DFGin 7.05 14.8279 ABAminus -125.48, -62.19 -62.72, 136.55 -132.76, 24.05 270.26, 81.1 -56.4, -43.64 in-out in 8.9564 Saltbr-out 6.8378 HRD-out -95.15, 91.19 -59.72, -45.2 out-in-out SNCoio in-out ActLoopNT-in 2.4184 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiii APE10-dihe-na -63.65, 141.8 APE9-dihe-na 169.57, -141.23 APE8-dihe-in -138.07, 164.32 APE8-rot-in 301.9 APE67-dihe-out 82.72, -175.36 -64.25, 106.81 APE12-dist-in 8.8541 APE11-dist-in 11.0152 APE10-dist-in 5.0432 APE9-dist-in 4.6257 None None None EM 3.8 999.0 999.0 8 507.0 402.0 64 107 61 46 [[33, 469]] 1.0 7pt7 Saccharomyces cerevisiae OTHER_CDC7_YEAST CMGC 4e-17 121.0 1.0 158.0 260.0 181 182 183 185 187 76 90 94 160 162 161 163.0 301 288 283 282 281 280 279 278 277 121 Cell division control protein 7
OTHER IRE1 IRE1_YEAST 2RIOA P32361 665 1115 1115.0 ADP:61101 ATPlike None DFGin 5.0319 14.6663 BLAminus -125.01, -166.82 59.91, 72.41 -79.74, 13.1 278.94, 57.84 -50.86, -29.29 out-in out 10.3602 Saltbr-in 3.5441 HRD-in -69.38, -55.95 80.27, 5.91 in-in-none SNCiin in-none ActLoopNT-in 2.6844 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 148.77 APE8-rot-in 240.38 APE67-dihe-in -59.81, -10.2 -102.36, 14.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.224 0.266 A 434.0 396.0 26 32 18 14 [[672, 977]] 1.0 2rio Saccharomyces cerevisiae OTHER_IRE1_YEAST TKL 1e-35 129.7 4.0 263.0 260.0 827 828 829 831 833 702 715 719 794 796 795 797.0 902 859 854 853 852 851 850 849 848 746 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER IRE1 IRE1_YEAST 2RIOB P32361 665 1115 1115.0 ADP:62101 ATPlike Inactive DFGin 5.1319 14.4012 BLAminus -133.23, -169.67 57.3, 77.4 -91.55, 18.06 279.67, 55.41 -50.86, -27.7 in-in in 9.9668 Saltbr-in 3.5542 HRD-in -79.44, -44.63 66.11, 11.75 in-in-out SNCiio in-out ActLoopNT-in 2.7644 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 139.02 APE8-rot-out 206.66 APE67-dihe-in -67.78, -12.45 -143.81, 21.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.224 0.266 B 434.0 395.0 27 32 18 14 [[672, 977]] 1.0 2rio Saccharomyces cerevisiae OTHER_IRE1_YEAST TKL 1e-35 129.7 4.0 263.0 260.0 827 828 829 831 833 702 715 719 794 796 795 797.0 902 859 854 853 852 851 850 849 848 746 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER IRE1 IRE1_YEAST 3LJ0A P32361 665 1115 1115.0 ADP:2101,QUE:1 ATPlike,Allosteric None DFGin 5.6568 14.5198 BLAminus -127.75, -159.8 55.73, 76.2 -100.97, 26.65 278.19, 55.54 -68.42, -38.12 in-in in 9.3145 Saltbr-in 3.0432 HRD-in -75.54, -40.03 69.65, -11.03 in-in-none SNCiin in-none ActLoopNT-in 2.8835 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -61.99 APE8-rot-none 999.0 APE67-dihe-in -81.59, -8.09 -104.48, 18.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP840,SEP841,TPO844 SEP840,SEP841,TPO844 XRAY 3.2 0.217 0.224 A 434.0 407.0 20 32 25 7 [[672, 977]] 1.0 3lj0 Saccharomyces cerevisiae OTHER_IRE1_YEAST TKL 1e-35 129.7 4.0 263.0 260.0 827 828 829 831 833 702 715 719 794 796 795 797.0 902 859 854 853 852 851 850 849 848 746 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER IRE1 IRE1_YEAST 3LJ0B P32361 670 1115 1115.0 ADP:2101,QUE:1 ATPlike,Allosteric None DFGin 5.6395 14.5291 BLAminus -127.76, -160.17 56.44, 75.29 -99.49, 26.48 278.86, 54.86 -67.91, -37.63 in-in in 9.3315 Saltbr-in 3.0881 HRD-in -76.48, -40.82 70.18, -10.34 in-in-none SNCiin in-none ActLoopNT-in 2.8642 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -62.45 APE8-rot-in 292.53 APE67-dihe-in -81.7, -8.3 -104.03, 18.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP840,SEP841,TPO844 SEP840,SEP841,TPO844 XRAY 3.2 0.217 0.224 B 434.0 402.0 20 32 25 7 [[672, 977]] 1.0 3lj0 Saccharomyces cerevisiae OTHER_IRE1_YEAST TKL 1e-35 129.7 4.0 263.0 260.0 827 828 829 831 833 702 715 719 794 796 795 797.0 902 859 854 853 852 851 850 849 848 746 Serine/threonine-protein kinase/endoribonuclease IRE1
TYR VKR2 A0A3Q0KQ92_SCHMA 7ZVSA A0A3Q0KQ92 943 1257 1641.0 ADP:1301 ATPlike Inactive DFGin 6.4107 13.9115 ABAminus -108.2, -51.57 -108.14, 130.38 -125.76, 34.81 311.68, 99.72 -69.75, -23.67 in-out in 7.915 Saltbr-out 4.4345 HRD-in -84.85, -39.64 60.03, 4.72 out-in-none SNCoin in-none ActLoopNT-in 3.1146 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.51 APE8-dihe-in -86.18, 75.72 APE8-rot-na 32.5 APE67-dihe-in -65.42, -24.56 -66.74, -36.8 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6537 None None None XRAY 3.07 0.219 0.252 A 341.0 300.0 15 33 18 15 [[966, 1240]] 1.0 7zvs Schistosoma mansoni TYR_VKR2_SCHMA TYR 2.6e-69 239.5 1.0 253.0 253.0 1117 1118 1119 1121 1123 997 1014 1018 1097 1099 1098 1100.0 1162 1150 1145 1144 1143 1142 1141 1140 1139 1045 Guanylate cyclase
TYR VKR2 A0A3Q0KQ92_SCHMA 7ZVSB A0A3Q0KQ92 946 1257 1641.0 ADP:1301 ATPlike Inactive DFGin 6.6225 14.5211 ABAminus -98.3, -71.59 -103.46, 126.3 -111.19, 44.98 301.93, 110.43 -72.41, -47.73 in-in in 8.9886 Saltbr-in 3.5916 HRD-in -85.3, -43.46 65.5, -4.13 in-in-none SNCiin in-none ActLoopNT-in 3.1678 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 149.82 APE9-dihe-in -99.67, 136.73 APE8-dihe-in -75.43, 94.78 APE8-rot-na 28.24 APE67-dihe-in -74.95, -28.65 -71.49, -32.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.7742 APE9-dist-in 6.6 None None None XRAY 3.07 0.219 0.252 B 341.0 296.0 16 33 17 16 [[966, 1240]] 1.0 7zvs Schistosoma mansoni TYR_VKR2_SCHMA TYR 2.6e-69 239.5 1.0 253.0 253.0 1117 1118 1119 1121 1123 997 1014 1018 1097 1099 1098 1100.0 1162 1150 1145 1144 1143 1142 1141 1140 1139 1045 Guanylate cyclase
OTHER YOPO Q93KQ6_YEREN 5CE3B Q93KQ6 108 729 729.0 ADP:60801 ATPlike Inactive None 999.0 999.0 None -135.72, -178.29 65.55, 68.88 -88.43, 18.62 274.24, 50.39 -58.33, -41.28 none-na none 999.0 Saltbr-na 999.0 HRD-in -75.96, -46.65 74.34, -12.04 na-in-out SNCaio in-out ActLoopNT-in 2.9309 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ooii APE10-dihe-na -168.45, -171.64 APE9-dihe-na -171.12, 163.26 APE8-dihe-in -100.11, 126.72 APE8-rot-in 306.6 APE67-dihe-in -62.68, -33.12 -66.23, -36.58 APE12-dist-out 6.8938 APE11-dist-out 3.8172 APE10-dist-in 5.1847 APE9-dist-in 3.949 K205Y,E206Y,E207Y,K440Y,K441Y None None XRAY 2.93 0.198 0.24 B 643.0 598.0 0 23 23 0 [[144, 405]] 1.0 5ce3 Yersinia enterocolitica OTHER_YOPO_YEREN STE 4.1e-06 32.8 55.0 256.0 202.0 285 286 287 289 291 0 0 0 264 266 265 267.0 321 308 303 302 301 300 299 298 297 212 YopO
OTHER YOPO Q93KQ6_YEREN 5CE3D Q93KQ6 108 729 729.0 ADP:60801 ATPlike Inactive None 999.0 999.0 None -137.87, -178.9 65.7, 69.62 -87.46, 18.2 287.37, 172.47 -59.1, -40.66 none-na none 999.0 Saltbr-na 999.0 HRD-in -75.41, -46.8 73.5, -11.21 na-in-out SNCaio in-out ActLoopNT-in 2.9231 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ooii APE10-dihe-na -169.34, -172.42 APE9-dihe-na -171.36, 163.27 APE8-dihe-in -100.95, 126.72 APE8-rot-in 306.77 APE67-dihe-in -63.23, -33.24 -66.66, -36.24 APE12-dist-out 6.8767 APE11-dist-out 3.8149 APE10-dist-in 5.1725 APE9-dist-in 3.9376 K205Y,E206Y,E207Y,K440Y,K441Y None None XRAY 2.93 0.198 0.24 D 643.0 598.0 0 23 23 0 [[144, 405]] 1.0 5ce3 Yersinia enterocolitica OTHER_YOPO_YEREN STE 4.1e-06 32.8 55.0 256.0 202.0 285 286 287 289 291 0 0 0 264 266 265 267.0 321 308 303 302 301 300 299 298 297 212 YopO

Ligand: ADP

Total number of chains: 111
Active chains: 46
Total number of genes: 36
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 78 70.3% 6EM7A
DFGin BLBplus 14 12.6% 8XN8A
None None 8 7.2% 4IX4A
DFGin ABAminus 5 4.5% 3TNQB
DFGin None 4 3.6% 5GZAA
DFGin BLBminus 2 1.8% 5M06B
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL BRI1 BRI1_ARATH 5LPBA O22476 867 1160 1196.0 ADP:1201 ATPlike Active DFGin 5.075 15.0582 BLAminus -134.68, 179.03 63.17, 81.59 -99.15, 20.06 285.86, 73.26 -60.78, -23.17 in-in in 8.6491 Saltbr-in 3.1477 HRD-in -69.16, -46.8 71.42, -2.74 in-in-in SNCiii in-in ActLoopNT-in 2.9288 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -107.78, 147.47 APE9-dihe-na 145.38, -170.04 APE8-dihe-in -133.78, 133.64 APE8-rot-in 306.07 APE67-dihe-inflip 102.35, -15.45 -46.22, 126.04 APE12-dist-in 9.2481 APE11-dist-in 11.2752 APE10-dist-in 5.4965 APE9-dist-in 3.7428 T872A TPO1039,SEP1042,SEP1044,SEP1060 TPO1039,SEP1042,SEP1044,SEP1060 XRAY 1.98 0.184 0.203 A 296.0 284.0 10 30 30 0 [[882, 1157]] 1.0 5lpb Arabidopsis thaliana TKL_BRI1_ARATH TKL 2e-63 220.4 4.0 266.0 263.0 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009.0 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL BRI1 BRI1_ARATH 5LPZA O22476 866 1160 1196.0 ADP:1200 ATPlike Active DFGin 5.2809 15.2287 BLAminus -133.61, -178.19 59.45, 71.09 -88.15, 19.11 288.53, 76.38 -60.79, -23.86 in-in in 8.6333 Saltbr-in 2.8287 HRD-in -68.17, -37.55 64.9, -2.92 in-in-in SNCiii in-in ActLoopNT-in 3.0224 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -69.74, 170.98 APE9-dihe-na 106.33, 162.6 APE8-dihe-in -102.72, 137.46 APE8-rot-in 305.68 APE67-dihe-inflip 102.78, -18.56 -57.05, 134.59 APE12-dist-in 9.3424 APE11-dist-in 11.7555 APE10-dist-in 5.7196 APE9-dist-in 3.5785 T872A TPO1039,SEP1042,SEP1044 TPO1039,SEP1042,SEP1044 XRAY 2.48 0.226 0.253 A 332.0 286.0 9 30 30 0 [[882, 1157]] 1.0 5lpz Arabidopsis thaliana TKL_BRI1_ARATH TKL 3e-63 219.9 4.0 266.0 263.0 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009.0 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL FERONIA FERON_ARATH 7XDXA Q9SCZ4 521 815 895.0 ADP:901 ATPlike Inactive DFGin 6.8683 15.5083 BLAminus -133.42, -178.74 67.64, 77.46 -97.26, 15.76 285.98, 88.34 -59.81, -31.94 in-out in 8.7215 Saltbr-out 5.533 HRD-in -65.25, -47.87 74.08, 0.6 out-in-none SNCoin in-none ActLoopNT-in 2.7617 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 135.64 APE8-rot-in 306.33 APE67-dihe-inflip 94.97, -23.67 -64.5, 138.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.23 0.184 0.235 A 313.0 280.0 15 30 15 15 [[535, 809]] 1.0 7xdx Arabidopsis thaliana TKL_FERONIA_ARATH TKL 2e-57 200.7 3.0 266.0 264.0 678 679 680 682 684 565 581 585 658 660 659 661.0 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
TKL FERONIA FERON_ARATH 7XDXB Q9SCZ4 521 815 895.0 ADP:901 ATPlike None DFGin 6.6219 15.4249 BLAminus -136.76, -177.06 63.7, 79.87 -96.73, 14.62 285.92, 71.87 -59.53, -21.5 in-in in 8.5759 Saltbr-in 3.3322 HRD-in -65.1, -49.82 75.49, 1.86 in-in-none SNCiin in-none ActLoopNT-in 2.7369 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 136.01 APE8-rot-in 320.81 APE67-dihe-inflip 95.62, -22.56 -64.49, 139.7 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.23 0.184 0.235 B 313.0 280.0 15 30 15 15 [[535, 809]] 1.0 7xdx Arabidopsis thaliana TKL_FERONIA_ARATH TKL 2e-57 200.7 3.0 266.0 264.0 678 679 680 682 684 565 581 585 658 660 659 661.0 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
TKL FERONIA FERON_ARATH 7XDYA Q9SCZ4 521 815 895.0 ADP:901 ATPlike Inactive DFGin 6.7592 15.7857 BLAminus -141.78, -171.91 66.87, 59.86 -83.38, 11.19 284.91, 77.98 -59.88, -27.32 in-out in 8.8858 Saltbr-out 5.6045 HRD-in -63.61, -43.27 68.91, 0.58 out-in-none SNCoin in-none ActLoopNT-in 2.8628 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 155.73 APE8-rot-in 307.09 APE67-dihe-inflip 97.81, -22.04 -77.29, 136.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.28 0.2 0.247 A 313.0 280.0 15 30 15 15 [[535, 809]] 1.0 7xdy Arabidopsis thaliana TKL_FERONIA_ARATH TKL 2e-57 200.7 3.0 266.0 264.0 678 679 680 682 684 565 581 585 658 660 659 661.0 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
TKL FERONIA FERON_ARATH 7XDYB Q9SCZ4 522 816 895.0 ADP:901 ATPlike Inactive DFGin 6.4485 16.0333 BLAminus -144.23, -178.13 65.87, 74.19 -94.93, 27.11 292.01, 67.35 -65.38, -32.71 in-out in 9.3487 Saltbr-out 6.0788 HRD-in -72.36, -52.52 79.98, -11.0 out-in-out SNCoio in-out ActLoopNT-in 2.784 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -15.92 APE8-rot-out 172.5 APE67-dihe-in -79.26, 18.24 -58.71, -66.01 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.28 0.2 0.247 B 313.0 280.0 15 30 15 15 [[535, 809]] 1.0 7xdy Arabidopsis thaliana TKL_FERONIA_ARATH TKL 2e-57 200.7 3.0 266.0 264.0 678 679 680 682 684 565 581 585 658 660 659 661.0 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
TKL FERONIA FERON_ARATH 7XDWA Q9SCZ4 521 815 895.0 ADP:901 ATPlike None DFGin 6.7365 15.7469 BLAminus -137.39, -174.63 58.35, 60.55 -84.66, 26.98 279.96, 82.38 -74.32, -25.62 in-none in 8.7321 Saltbr-none 999.0 HRD-in -69.86, -44.55 71.98, 2.17 none-in-none SNCnin in-none ActLoopNT-in 2.918 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 144.08 APE8-rot-in 320.64 APE67-dihe-in -58.47, -9.87 -56.6, -62.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.926 0.188 0.207 A 313.0 281.0 14 30 16 14 [[535, 809]] 1.0 7xdw Arabidopsis thaliana TKL_FERONIA_ARATH TKL 8.2e-57 198.7 3.0 266.0 264.0 678 679 680 682 684 565 581 585 658 660 659 661.0 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
TKL FERONIA FERON_ARATH 7XDWB Q9SCZ4 522 816 895.0 ADP:901 ATPlike None DFGin 6.7079 15.5191 BLAminus -137.44, -171.65 65.06, 59.01 -87.27, 21.93 280.32, 83.86 -70.86, -24.01 in-none in 8.7017 Saltbr-none 999.0 HRD-in -70.0, -44.65 71.38, 1.15 none-in-none SNCnin in-none ActLoopNT-in 2.9442 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 146.34 APE8-rot-in 314.87 APE67-dihe-inflip 95.5, -19.53 -58.77, 130.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.926 0.188 0.207 B 313.0 281.0 14 30 16 14 [[535, 809]] 1.0 7xdw Arabidopsis thaliana TKL_FERONIA_ARATH TKL 8.2e-57 198.7 3.0 266.0 264.0 678 679 680 682 684 565 581 585 658 660 659 661.0 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
AGC GRK1 GRK1_BOVIN 3C4ZA P28327 31 533 561.0 ADP:562 ATPlike Active DFGin 5.9128 13.2351 BLAminus -149.46, 171.26 70.91, 78.39 -108.02, 16.47 270.55, 111.24 -69.43, -16.01 in-in in 8.7363 Saltbr-in 2.7164 HRD-in -71.08, -53.07 69.31, 6.53 in-in-in SNCiii in-in ActLoopNT-in 2.8781 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.53, 147.45 APE9-dihe-na 134.96, -165.72 APE8-dihe-in -111.39, 128.56 APE8-rot-in 296.58 APE67-dihe-inflip 96.79, -17.75 -54.96, 131.39 APE12-dist-in 10.4298 APE11-dist-in 11.1131 APE10-dist-in 5.4905 APE9-dist-in 3.5422 None None None XRAY 1.84 0.193 999.0 A 543.0 493.0 0 28 28 0 [[187, 452]] 1.0 3c4z Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4.0 260.0 257.0 331 332 333 335 337 216 235 239 311 313 312 314.0 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C50A P28327 30 533 561.0 ADP:562 ATPlike Active DFGin 6.0752 13.0339 BLAminus -142.59, 172.43 68.85, 78.38 -104.12, 14.36 280.99, 104.76 -67.57, -15.07 in-in in 8.6024 Saltbr-in 2.9252 HRD-in -76.21, -52.36 64.46, 15.62 in-in-in SNCiii in-in ActLoopNT-in 2.7949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.66, 144.27 APE9-dihe-na 130.37, -165.26 APE8-dihe-in -104.68, 131.22 APE8-rot-in 300.48 APE67-dihe-inflip 92.29, -6.18 -56.88, 135.03 APE12-dist-in 10.685 APE11-dist-in 11.4689 APE10-dist-in 5.8763 APE9-dist-in 3.4729 None None None XRAY 2.6 0.19 999.0 A 543.0 499.0 0 28 28 0 [[187, 452]] 1.0 3c50 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4.0 260.0 257.0 331 332 333 335 337 216 235 239 311 313 312 314.0 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C50B P28327 30 533 561.0 ADP:562 ATPlike Active DFGin 6.0782 13.0677 BLAminus -140.52, 175.4 66.53, 77.05 -104.14, 18.55 279.39, 103.87 -67.23, -21.39 in-in in 8.5322 Saltbr-in 2.7211 HRD-in -71.74, -52.34 63.89, 11.32 in-in-in SNCiii in-in ActLoopNT-in 2.8901 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.47, 143.37 APE9-dihe-na 137.53, -168.17 APE8-dihe-in -105.39, 125.32 APE8-rot-in 297.12 APE67-dihe-inflip 95.82, -17.57 -51.32, 135.4 APE12-dist-in 10.1294 APE11-dist-in 11.1147 APE10-dist-in 5.5383 APE9-dist-in 3.4184 None None None XRAY 2.6 0.19 999.0 B 543.0 496.0 0 28 28 0 [[187, 452]] 1.0 3c50 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4.0 260.0 257.0 331 332 333 335 337 216 235 239 311 313 312 314.0 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C51A P28327 31 533 561.0 ADP:562 ATPlike Active DFGin 5.7354 13.2354 BLAminus -156.28, 178.74 57.85, 73.51 -84.14, -2.01 283.03, 106.57 -47.35, -22.99 in-in in 8.7977 Saltbr-in 2.6866 HRD-in -64.41, -45.82 69.5, -19.46 in-in-in SNCiii in-in ActLoopNT-in 2.9155 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -176.64, 142.5 APE9-dihe-na 155.52, -169.52 APE8-dihe-in -101.5, 135.25 APE8-rot-in 300.99 APE67-dihe-inflip 84.91, 4.53 -59.96, 128.0 APE12-dist-in 10.573 APE11-dist-in 11.5413 APE10-dist-in 6.1515 APE9-dist-in 3.937 None None None XRAY 3.55 0.281 999.0 A 543.0 487.0 0 28 28 0 [[187, 452]] 1.0 3c51 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4.0 260.0 257.0 331 332 333 335 337 216 235 239 311 313 312 314.0 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C51B P28327 31 533 561.0 ADP:562 ATPlike Active DFGin 5.7851 13.1869 BLAminus -156.29, 175.57 58.57, 74.43 -85.29, -1.69 285.99, 107.07 -47.38, -22.91 in-in in 8.696 Saltbr-in 2.7915 HRD-in -66.67, -42.5 63.68, -15.39 in-in-in SNCiii in-in ActLoopNT-in 2.9686 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -176.05, 141.93 APE9-dihe-na 155.26, -171.96 APE8-dihe-in -101.33, 138.35 APE8-rot-in 299.85 APE67-dihe-inflip 84.6, 5.24 -64.39, 128.67 APE12-dist-in 10.5371 APE11-dist-in 11.5977 APE10-dist-in 6.1564 APE9-dist-in 3.9396 None None None XRAY 3.55 0.281 999.0 B 543.0 461.0 20 28 28 0 [[187, 452]] 1.0 3c51 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4.0 260.0 257.0 331 332 333 335 337 216 235 239 311 313 312 314.0 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3QC9A P28327 31 533 561.0 ADP:700 ATPlike Active DFGin 6.8516 13.4841 BLAminus -151.04, 174.48 70.22, 99.25 -129.57, 18.73 275.22, 99.19 -61.63, -18.96 in-in in 8.9606 Saltbr-in 3.1273 HRD-in -61.98, -58.15 73.37, -3.42 in-in-in SNCiii in-in ActLoopNT-in 2.9166 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -167.32, 133.82 APE9-dihe-na 142.48, -169.15 APE8-dihe-in -104.33, 125.71 APE8-rot-in 302.67 APE67-dihe-inflip 104.42, -3.83 -50.74, 122.55 APE12-dist-in 10.3557 APE11-dist-in 11.0144 APE10-dist-in 5.5004 APE9-dist-in 3.6645 T8C,N480C None None XRAY 2.7 0.194 0.229 A 543.0 486.0 0 28 28 0 [[187, 452]] 1.0 3qc9 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4.0 260.0 257.0 331 332 333 335 337 216 235 239 311 313 312 314.0 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3QC9B P28327 31 533 561.0 ADP:700 ATPlike Active DFGin 6.8991 13.5043 BLAminus -154.17, 173.67 70.5, 100.81 -132.54, 18.75 276.87, 97.69 -56.57, -24.02 in-in in 8.931 Saltbr-in 3.099 HRD-in -65.24, -58.34 73.4, -2.88 in-in-in SNCiii in-in ActLoopNT-in 2.9339 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -166.53, 132.45 APE9-dihe-na 145.72, -169.79 APE8-dihe-in -103.09, 126.5 APE8-rot-in 303.38 APE67-dihe-inflip 99.94, -4.73 -52.12, 123.93 APE12-dist-in 10.3676 APE11-dist-in 11.0383 APE10-dist-in 5.525 APE9-dist-in 3.6772 T8C,N480C None None XRAY 2.7 0.194 0.229 B 543.0 481.0 0 28 28 0 [[187, 452]] 1.0 3qc9 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4.0 260.0 257.0 331 332 333 335 337 216 235 239 311 313 312 314.0 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3QC9C P28327 31 533 561.0 ADP:700 ATPlike Active DFGin 6.8677 13.481 BLAminus -151.87, 172.48 72.03, 98.62 -128.19, 19.72 276.34, 98.38 -59.47, -19.79 in-in in 8.9508 Saltbr-in 3.1074 HRD-in -62.09, -58.44 72.04, -1.68 in-in-in SNCiii in-in ActLoopNT-in 2.9357 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -168.26, 134.05 APE9-dihe-na 142.83, -170.11 APE8-dihe-in -104.04, 126.58 APE8-rot-in 301.36 APE67-dihe-inflip 105.14, -2.81 -49.9, 120.73 APE12-dist-in 10.3838 APE11-dist-in 11.0185 APE10-dist-in 5.5081 APE9-dist-in 3.673 T8C,N480C None None XRAY 2.7 0.194 0.229 C 543.0 482.0 0 28 28 0 [[187, 452]] 1.0 3qc9 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4.0 260.0 257.0 331 332 333 335 337 216 235 239 311 313 312 314.0 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3QC9D P28327 31 533 561.0 ADP:700 ATPlike Active DFGin 6.9233 13.5167 BLAminus -151.29, 174.11 71.25, 99.27 -130.54, 20.81 276.77, 98.72 -58.99, -24.3 in-in in 8.9307 Saltbr-in 3.0905 HRD-in -63.44, -57.63 71.87, -0.43 in-in-in SNCiii in-in ActLoopNT-in 2.9269 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.95, 134.69 APE9-dihe-na 141.2, -168.54 APE8-dihe-in -103.28, 126.55 APE8-rot-in 303.76 APE67-dihe-inflip 102.49, -2.5 -51.29, 121.62 APE12-dist-in 10.3966 APE11-dist-in 11.0439 APE10-dist-in 5.5135 APE9-dist-in 3.693 T8C,N480C None None XRAY 2.7 0.194 0.229 D 543.0 486.0 0 28 28 0 [[187, 452]] 1.0 3qc9 Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4.0 260.0 257.0 331 332 333 335 337 216 235 239 311 313 312 314.0 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
CK1 HRR25 Q6FS46_CANGA 4XH0A Q6FS46 3 397 495.0 ADP:501 ATPlike None DFGin 6.443 15.3833 BLAminus -128.64, -179.51 59.61, 77.98 -98.4, 10.06 283.06, 95.13 -55.51, -31.98 in-none in 8.1487 Saltbr-none 999.0 HRD-in -77.95, -46.78 69.84, 1.34 none-in-in SNCnii in-in ActLoopNT-in 2.7696 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.48, 125.7 APE9-dihe-na -118.27, -46.73 APE8-dihe-in -107.01, 112.94 APE8-rot-in 317.73 APE67-dihe-in -59.61, -42.11 -60.33, -32.21 APE12-dist-in 13.2808 APE11-dist-in 12.5221 APE10-dist-in 6.9261 APE9-dist-in 5.2004 K38R None None XRAY 1.99 0.168 0.2 A 403.0 350.0 5 35 35 0 [[9, 275]] 1.0 4xh0 Candida glabrata CK1_HRR25_CANGA CK1 2.6e-101 344.7 1.0 261.0 261.0 148 149 150 152 154 38 52 56 125 127 126 128.0 195 183 178 177 176 175 174 173 172 83 non-specific serine/threonine protein kinase
CK1 HRR25 Q6FS46_CANGA 4XHGA Q6FS46 2 397 495.0 ADP:501 ATPlike Inactive DFGin 6.7681 15.5237 BLAminus -126.45, -178.1 65.49, 74.25 -101.88, 16.36 285.39, 86.86 -58.89, -30.96 in-none in 8.2372 Saltbr-none 999.0 HRD-in -77.78, -51.52 75.28, -1.16 none-in-out SNCnio in-out ActLoopNT-in 2.8504 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -115.41, -44.98 APE9-dihe-na -99.02, -152.38 APE8-dihe-in -72.06, 134.26 APE8-rot-in 284.45 APE67-dihe-in -61.84, -37.14 -105.15, 28.83 APE12-dist-in 12.9854 APE11-dist-in 12.4375 APE10-dist-out 8.315 APE9-dist-out 8.1809 K38R None None XRAY 2.15 0.176 0.216 A 403.0 357.0 0 35 35 0 [[9, 275]] 1.0 4xhg Candida glabrata CK1_HRR25_CANGA CK1 2.6e-101 344.7 1.0 261.0 261.0 148 149 150 152 154 38 52 56 125 127 126 128.0 195 183 178 177 176 175 174 173 172 83 non-specific serine/threonine protein kinase
AGC PRKACA KAPCA_CRIGR 6EM6A P25321 12 351 351.0 ADP:60401 ATPlike Inactive DFGin 6.8591 14.8208 BLAminus -128.32, 163.45 74.87, 92.52 -104.27, 28.45 286.23, 74.8 -62.75, -23.58 in-out in 9.7038 Saltbr-out 4.3621 HRD-in -85.36, -55.87 71.35, 12.71 out-in-in SNCoii in-in ActLoopNT-in 2.9302 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.91, 157.75 APE9-dihe-na 127.42, -164.4 APE8-dihe-in -115.9, 133.37 APE8-rot-in 304.12 APE67-dihe-in -57.32, -23.54 -48.16, -51.44 APE12-dist-in 8.0456 APE11-dist-in 11.3093 APE10-dist-in 5.7368 APE9-dist-in 3.819 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.64 0.175 0.191 A 353.0 340.0 0 25 25 0 [[44, 298]] 1.0 6em6 Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6EM7A P25321 11 351 351.0 ADP:60403 ATPlike Active DFGin 5.924 14.3384 BLAminus -118.71, 173.1 68.53, 85.06 -96.18, 23.36 270.78, 55.34 -59.75, -28.55 in-in in 8.7405 Saltbr-in 2.7108 HRD-in -88.33, -53.93 74.88, 10.19 in-in-in SNCiii in-in ActLoopNT-in 2.9674 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.73, 159.92 APE9-dihe-na 127.98, -160.75 APE8-dihe-in -119.5, 137.47 APE8-rot-in 298.57 APE67-dihe-in -59.39, -22.73 -49.47, -50.59 APE12-dist-in 8.0499 APE11-dist-in 11.4294 APE10-dist-in 5.809 APE9-dist-in 3.6743 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.238 0.139 0.157 A 353.0 341.0 0 25 25 0 [[44, 298]] 1.0 6em7 Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CMGC CDK Q5CRJ8_CRYPI 3NIZA Q5CRJ8 1 293 295.0 ADP:60314 ATPlike Inactive DFGin 6.414 14.9205 BLAminus -148.14, 171.85 62.34, 76.33 -90.55, 26.42 283.17, 83.82 -64.08, -27.13 in-in in 9.1988 Saltbr-in 3.0509 HRD-in -69.04, -53.75 72.92, -5.13 in-in-out SNCiio in-out ActLoopNT-in 2.9042 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -75.55, 106.41 APE9-dihe-na -120.78, 159.03 APE8-dihe-in -63.65, 138.42 APE8-rot-out 189.36 APE67-dihe-in -64.68, -19.03 -103.04, 13.52 APE12-dist-in 10.7004 APE11-dist-in 9.7673 APE10-dist-out 13.8921 APE9-dist-out 9.5481 None None None XRAY 2.4 0.223 0.256 A 311.0 284.0 9 28 25 3 [[5, 286]] 1.0 3niz Cryptosporidium parvum CMGC_CDK_CRYPI CMGC 1.9e-86 296.3 1.0 301.0 301.0 143 144 145 147 149 33 51 55 123 125 124 126.0 184 171 166 165 164 163 162 161 160 81 Cyclin-dependent kinase 2 homolog
CAMK PLK1 Q4KMI8_DANRE 3D5WA Q4KMI8 24 310 595.0 ADP:313 ATPlike Inactive DFGin 5.8398 15.103 BLAminus -136.31, -173.3 52.58, 90.43 -100.9, 29.72 290.61, 88.81 -67.31, -18.54 out-out out 10.538 Saltbr-out 4.5698 HRD-in -72.81, -47.33 67.56, -5.93 out-in-in SNCoii in-in ActLoopNT-in 2.9013 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.0, 153.74 APE9-dihe-na 145.11, -167.91 APE8-dihe-in -110.25, 127.19 APE8-rot-in 299.86 APE67-dihe-in -70.02, -15.96 -37.98, -47.89 APE12-dist-in 8.2509 APE11-dist-in 11.2747 APE10-dist-in 5.6458 APE9-dist-in 3.9124 None TPO196 TPO196 XRAY 2.6 0.244 0.271 A 317.0 285.0 2 28 28 0 [[39, 291]] 1.0 3d5w Danio rerio CAMK_PLK1_DANRE CAMK 4.6e-77 264.7 1.0 256.0 256.0 179 180 181 183 185 68 87 91 159 161 160 162.0 219 207 202 201 200 199 198 197 196 117 Serine/threonine-protein kinase PLK
OTHER POMK SG196_DANRE 5GZAA Q5U3W1 53 342 347.0 ADP:401,ZZ1:405 ATPlike,Allosteric Pseudo DFGin 5.3569 13.1741 None -145.49, -53.43 -88.36, 87.6 -105.44, 34.02 303.67, 0.43 -66.19, -35.84 none-na none 999.0 Saltbr-na 999.0 HRD-out -76.02, 100.34 -84.46, -37.81 na-in-out SNCaio in-out ActLoopNT-in 3.1764 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_iioo APE10-dihe-na -72.0, 131.22 APE9-dihe-na -98.58, 149.02 APE8-dihe-in -137.88, 170.05 APE8-rot-out 49.36 APE67-dihe-out -89.83, -15.07 100.95, 169.89 APE12-dist-in 12.1638 APE11-dist-in 13.9361 APE10-dist-out 17.3588 APE9-dist-out 9.4145 None None None XRAY 2.0 0.203 0.218 A 290.0 290.0 0 30 30 0 [[72, 335]] 1.0 5gza Danio rerio OTHER_POMK_DANRE POMK 3.3e-138 465.4 1.0 265.0 265.0 224 225 226 228 230 106 120 124 199 201 200 202.0 278 254 249 248 247 246 245 244 243 148 Protein O-mannose kinase
CAMK CAMKII KCC2A_DROME 5FG8A Q00168 7 275 530.0 ADP:301 ATPlike Active DFGin 5.8825 14.2303 BLAminus -120.35, -179.38 64.2, 77.37 -92.62, 22.59 287.14, 78.3 -59.18, -27.49 in-in in 8.9956 Saltbr-in 2.7976 HRD-in -79.26, -45.5 78.31, -3.25 in-in-in SNCiii in-in ActLoopNT-in 2.9362 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.29, 153.59 APE9-dihe-na 138.39, -158.82 APE8-dihe-in -123.15, 126.57 APE8-rot-in 291.32 APE67-dihe-in -61.12, -15.42 -38.96, -61.46 APE12-dist-in 10.2082 APE11-dist-in 11.8158 APE10-dist-in 6.2893 APE9-dist-in 3.4793 None None None XRAY 1.955 0.192 0.221 A 285.0 269.0 0 28 28 0 [[14, 272]] 1.0 5fg8 Drosophila melanogaster CAMK_CAMKII_DROME CAMK 6.3e-98 333.1 1.0 256.0 256.0 156 157 158 160 162 43 61 65 133 135 134 136.0 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II alpha chain
CAMK CAMKII KCC2A_DROME 5HU3A Q00168 7 272 530.0 ADP:301 ATPlike Active DFGin 5.6249 14.217 BLAminus -125.3, -175.54 57.54, 73.58 -90.7, 26.83 289.37, 84.29 -62.44, -29.23 in-in in 8.9517 Saltbr-in 2.6715 HRD-in -75.88, -45.31 74.57, -1.26 in-in-in SNCiii in-in ActLoopNT-in 2.9044 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.12, 157.18 APE9-dihe-na 139.99, -158.88 APE8-dihe-in -121.63, 130.83 APE8-rot-in 294.31 APE67-dihe-in -66.75, -12.95 -42.37, -59.45 APE12-dist-in 10.0585 APE11-dist-in 11.7662 APE10-dist-in 6.2771 APE9-dist-in 3.5644 D136N None None XRAY 1.885 0.194 0.228 A 285.0 266.0 0 28 28 0 [[14, 272]] 1.0 5hu3 Drosophila melanogaster CAMK_CAMKII_DROME CAMK 5.7e-97 329.9 1.0 256.0 256.0 156 157 158 160 162 43 61 65 133 135 134 136.0 196 184 179 178 177 176 175 174 173 91 Calcium/calmodulin-dependent protein kinase type II alpha chain
CAMK OBSCN-1 OBSCN_DROME 8AK3A A8DYP0 3186 3477 4218.0 ADP:63501 ATPlike Pseudo DFGin 5.9051 13.4845 BLAminus -132.07, -172.8 60.67, 81.34 -101.92, 21.49 307.26, 110.13 -57.27, -33.59 in-in in 7.72 Saltbr-in 2.7612 HRD-in -74.37, -46.4 81.73, -14.06 in-in-in SNCiii in-in ActLoopNT-in 2.8971 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na -140.07, 151.0 APE9-dihe-na 162.46, 172.55 APE8-dihe-in -86.0, 119.15 APE8-rot-na 203.36 APE67-dihe-in -78.57, -5.95 -56.15, -31.0 APE12-dist-in 8.0475 APE11-dist-in 10.0079 APE10-dist-in 6.6911 APE9-dist-in 5.7871 None None None XRAY 1.9 0.175 0.208 A 297.0 292.0 0 27 27 0 [[3186, 3440], [3897, 4151]] 2.0 8ak3 Drosophila melanogaster CAMK_OBSCN-1_DROME CAMK 2.3e-61 213.3 1.0 256.0 256.0 3325 3326 3327 3329 3331 3215 3230 3234 3303 3305 3304 3306.0 3364 3352 3347 3346 3345 3344 3343 3342 3341 3260 Protein Obscurin
OTHER BUBR1 A1Z6I7_DROME 6JKMA A1Z6I7 1127 1459 1460.0 ADP:61501 ATPlike Inactive DFGin 6.0094 13.9481 BLAminus -128.73, 177.45 65.82, 73.45 -92.38, 26.0 302.65, 107.99 -57.62, -35.04 in-in in 8.3334 Saltbr-in 2.9873 HRD-in -63.93, -46.09 73.48, 2.84 in-in-out SNCiio in-out ActLoopNT-in 2.7547 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_iooo APE10-dihe-na -54.34, 146.08 APE9-dihe-na -76.3, -56.25 APE8-dihe-in -62.83, 122.42 APE8-rot-na 191.74 APE67-dihe-in -57.79, -24.72 -57.87, -34.67 APE12-dist-in 12.1217 APE11-dist-out 15.9738 APE10-dist-out 12.4259 APE9-dist-out 12.3951 None None None XRAY 1.95 0.181 0.226 A 341.0 333.0 0 30 30 0 [[1175, 1438]] 1.0 6jkm Drosophila melanogaster OTHER_BUBR1_DROME BUB 7.6e-133 447.7 1.0 265.0 265.0 1325 1326 1327 1329 1331 1204 1213 1217 1298 1300 1299 1301.0 1367 1355 1350 1349 1348 1347 1346 1345 1344 1251 Bub1-related kinase
CAMK CDPK Q3HNM4_EIMTE 4YSJA Q3HNM4 26 499 505.0 ADP:60506 ATPlike Active DFGin 6.6513 14.0048 BLAminus -140.39, -165.72 52.75, 66.63 -84.34, 22.0 285.15, 82.54 -78.31, -16.63 in-in in 8.3189 Saltbr-in 3.4823 HRD-in -81.29, -53.0 84.02, -6.2 in-in-in SNCiii in-in ActLoopNT-in 2.8976 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.58, 142.92 APE9-dihe-na 138.88, -163.22 APE8-dihe-in -136.98, 140.82 APE8-rot-in 303.29 APE67-dihe-in -62.88, -33.46 -45.59, -53.66 APE12-dist-in 9.1442 APE11-dist-in 11.5637 APE10-dist-in 5.9896 APE9-dist-in 3.4927 None None None XRAY 2.7 0.249 0.292 A 491.0 459.0 10 27 27 0 [[46, 303]] 1.0 4ysj Eimeria tenella CAMK_CDPK_EIMTE CAMK 6.1e-90 307.2 1.0 256.0 256.0 189 190 191 193 195 75 94 98 166 168 167 169.0 227 216 211 210 209 208 207 206 205 124 non-specific serine/threonine protein kinase
CAMK CDPK Q3HNM4_EIMTE 4YSJB Q3HNM4 26 499 505.0 ADP:60506 ATPlike Active DFGin 6.5952 13.9931 BLAminus -140.54, -165.92 54.1, 65.38 -84.49, 22.28 285.29, 82.38 -78.18, -16.85 in-in in 8.3003 Saltbr-in 3.4937 HRD-in -81.3, -52.72 84.55, -6.86 in-in-in SNCiii in-in ActLoopNT-in 2.8688 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.46, 142.21 APE9-dihe-na 137.64, -162.65 APE8-dihe-in -138.56, 141.54 APE8-rot-in 303.24 APE67-dihe-in -62.83, -32.98 -44.74, -55.37 APE12-dist-in 8.9007 APE11-dist-in 11.534 APE10-dist-in 5.9792 APE9-dist-in 3.5054 None None None XRAY 2.7 0.249 0.292 B 491.0 462.0 10 27 27 0 [[46, 303]] 1.0 4ysj Eimeria tenella CAMK_CDPK_EIMTE CAMK 6.1e-90 307.2 1.0 256.0 256.0 189 190 191 193 195 75 94 98 166 168 167 169.0 227 216 211 210 209 208 207 206 205 124 non-specific serine/threonine protein kinase
OTHER STT7 C1EBN1_MICCC 4IX4A C1EBN1 151 489 489.0 ADP:60601 none Inactive None 999.0 999.0 None -124.77, 172.55 68.64, 78.1 -90.38, 21.25 292.81, 157.07 -65.27, -19.84 none-na none 999.0 Saltbr-na 999.0 HRD-na- -69.85, -47.17 71.62, 4.08 na-in-none SNCain in-none ActLoopNT-in 2.9597 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.499 0.163 0.199 A 350.0 339.0 0 -337 -337 0 [[62, 488]] 1.0 4ix4 Micromonas commoda OTHER_STT7_MICCC CMGC 1.3e-08 61.8 104.0 156.0 81.0 337 338 339 341 343 0 0 0 315 317 316 318.0 0 0 0 0 0 0 0 0 0 0 Protein kinase domain-containing protein
OTHER STT7 C1EBN1_MICCC 4IX4B C1EBN1 151 489 489.0 ADP:60601 none Inactive None 999.0 999.0 None -124.06, 172.31 67.36, 81.18 -93.11, 18.85 292.92, 160.57 -65.85, -21.57 none-na none 999.0 Saltbr-na 999.0 HRD-na- -69.18, -45.52 70.51, 2.0 na-in-none SNCain in-none ActLoopNT-in 2.9526 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.499 0.163 0.199 B 350.0 339.0 0 -337 -337 0 [[62, 488]] 1.0 4ix4 Micromonas commoda OTHER_STT7_MICCC CMGC 1.3e-08 61.8 104.0 156.0 81.0 337 338 339 341 343 0 0 0 315 317 316 318.0 0 0 0 0 0 0 0 0 0 0 Protein kinase domain-containing protein
OTHER STT7 C1EBN1_MICCC 4IX6A C1EBN1 151 489 489.0 ADP:60601 none Inactive None 999.0 999.0 None -121.42, 171.38 68.63, 78.17 -88.85, 21.64 296.86, 161.4 -62.59, -24.51 none-na none 999.0 Saltbr-na 999.0 HRD-na- -70.26, -46.59 73.56, 1.3 na-in-none SNCain in-none ActLoopNT-in 2.9486 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.6 0.174 0.193 A 350.0 339.0 0 -337 -337 0 [[62, 488]] 1.0 4ix6 Micromonas commoda OTHER_STT7_MICCC CMGC 1.3e-08 61.8 104.0 156.0 81.0 337 338 339 341 343 0 0 0 315 317 316 318.0 0 0 0 0 0 0 0 0 0 0 Protein kinase domain-containing protein
OTHER STT7 C1EBN1_MICCC 4IX6B C1EBN1 151 489 489.0 ADP:60601 none Inactive None 999.0 999.0 None -120.88, 168.28 70.6, 77.38 -87.7, 20.1 294.13, 158.65 -62.82, -23.17 none-na none 999.0 Saltbr-na 999.0 HRD-na- -69.85, -45.21 71.7, -0.13 na-in-none SNCain in-none ActLoopNT-in 2.9667 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.6 0.174 0.193 B 350.0 339.0 0 -337 -337 0 [[62, 488]] 1.0 4ix6 Micromonas commoda OTHER_STT7_MICCC CMGC 1.3e-08 61.8 104.0 156.0 81.0 337 338 339 341 343 0 0 0 315 317 316 318.0 0 0 0 0 0 0 0 0 0 0 Protein kinase domain-containing protein
TKL RIPK A0A811MS43_9POAL 8HODA A0A811MS43 82 379 435.0 ADP:60401 ATPlike Inactive DFGin 5.8334 13.3727 BLBplus -121.78, 161.33 63.78, 18.48 -72.74, 142.38 54.34, 88.33 69.05, 9.41 out-out out 13.9488 Saltbr-out 11.8453 HRD-out -80.81, 162.08 -71.22, -39.02 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_oooo APE10-dihe-na -63.8, 122.58 APE9-dihe-na 79.64, 3.1 APE8-dihe-in -72.72, 144.78 APE8-rot-out 54.39 APE67-dihe-out 108.47, -0.29 -117.76, 31.22 APE12-dist-out 17.5773 APE11-dist-out 21.1323 APE10-dist-out 20.0913 APE9-dist-out 12.2033 S262A,T263A None None XRAY 1.95 0.201 0.228 A 326.0 279.0 19 30 21 9 [[97, 377]] 1.0 8hod Miscanthus lutarioriparius TKL_RIPK_9POAL TKL 6.7e-60 208.9 4.0 266.0 263.0 245 246 247 249 251 133 149 153 225 227 226 228.0 287 275 270 269 268 267 266 265 264 179 non-specific serine/threonine protein kinase
AGC PRKACA KAPCA_MOUSE 4NTTB P05132 11 351 351.0 ADP:60401 ATPlike Inactive DFGin 6.5417 14.8798 ABAminus -93.85, -35.44 -119.41, 118.31 -113.9, 43.83 296.85, 78.9 -65.87, -49.34 in-none in 9.8688 Saltbr-none 999.0 HRD-in -94.05, -37.34 60.44, 1.66 none-in-in SNCnii in-in ActLoopNT-in 2.7867 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -166.4, 146.42 APE9-dihe-na 126.7, -158.4 APE8-dihe-in -116.99, 137.33 APE8-rot-in 273.8 APE67-dihe-in -64.02, -34.69 -52.94, -43.07 APE12-dist-in 7.7129 APE11-dist-in 10.7197 APE10-dist-in 5.2983 APE9-dist-in 4.164 K8C TPO198,SEP339 TPO198,SEP339 XRAY 3.5 0.23 0.284 B 350.0 341.0 0 25 25 0 [[44, 298]] 1.0 4ntt Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4O21A P05132 16 351 351.0 ADP:60401 ATPlike Active DFGin 6.0367 14.4393 BLAminus -125.27, 173.53 70.53, 83.75 -96.26, 25.58 272.04, 54.28 -57.91, -27.19 in-in in 8.9531 Saltbr-in 2.7155 HRD-in -83.95, -57.84 75.15, 8.54 in-in-in SNCiii in-in ActLoopNT-in 2.9043 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.15, 164.3 APE9-dihe-na 125.14, -151.92 APE8-dihe-in -125.51, 129.66 APE8-rot-in 308.07 APE67-dihe-in -63.53, -19.17 -43.91, -48.76 APE12-dist-in 8.0396 APE11-dist-in 11.4602 APE10-dist-in 5.9112 APE9-dist-in 3.4511 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.95 0.17 0.215 A 342.0 336.0 0 25 25 0 [[44, 298]] 1.0 4o21 Mus musculus AGC_PRKACA_MOUSE AGC 1.4e-94 322.2 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 1L3RE P05132 2 351 351.0 ADP:60381 ATPlike Active DFGin 5.7538 14.4402 BLAminus -119.14, -174.46 57.18, 81.19 -93.77, 20.31 270.88, 52.04 -50.0, -37.57 in-in in 9.0231 Saltbr-in 2.7924 HRD-in -82.45, -54.36 70.16, 7.26 in-in-in SNCiii in-in ActLoopNT-in 2.9201 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.84, 161.06 APE9-dihe-na 132.7, -149.01 APE8-dihe-in -131.06, 132.91 APE8-rot-in 298.56 APE67-dihe-in -55.27, -27.25 -33.24, -62.94 APE12-dist-in 8.1978 APE11-dist-in 11.2333 APE10-dist-in 5.8253 APE9-dist-in 3.3679 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 2.0 0.205 0.232 E 350.0 341.0 0 25 25 0 [[44, 298]] 1.0 1l3r Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DH5A P05132 16 351 351.0 ADP:60403 ATPlike Active DFGin 6.1214 14.3392 BLAminus -125.12, -179.76 61.4, 85.13 -97.61, 27.77 279.05, 62.21 -46.99, -44.52 in-in in 9.0432 Saltbr-in 2.5524 HRD-in -77.92, -53.51 67.68, 1.05 in-in-in SNCiii in-in ActLoopNT-in 2.9684 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.88, 153.17 APE9-dihe-na 132.88, -161.89 APE8-dihe-in -112.07, 131.8 APE8-rot-in 304.21 APE67-dihe-in -57.01, -23.17 -41.47, -55.69 APE12-dist-in 8.2186 APE11-dist-in 11.6017 APE10-dist-in 6.0711 APE9-dist-in 3.87 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.2 0.187 0.222 A 350.0 336.0 0 25 25 0 [[44, 298]] 1.0 4dh5 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 5JR7A P05132 14 351 351.0 ADP:60400 ATPlike Active DFGin 5.7387 13.6907 BLAminus -145.14, 176.28 64.37, 76.68 -85.75, 18.89 294.14, 59.99 -43.66, -41.86 in-in in 8.6743 Saltbr-in 2.7095 HRD-in -93.38, -54.67 74.91, 7.39 in-in-in SNCiii in-in ActLoopNT-in 2.945 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.46, 148.2 APE9-dihe-na 147.95, -159.28 APE8-dihe-in -109.66, 131.32 APE8-rot-in 258.88 APE67-dihe-in -65.5, -25.8 -38.64, -53.47 APE12-dist-in 8.0144 APE11-dist-in 10.772 APE10-dist-in 5.5284 APE9-dist-in 3.8782 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.56 0.269 0.322 A 350.0 338.0 0 25 25 0 [[44, 298]] 1.0 5jr7 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 5JR7C P05132 14 351 351.0 ADP:60400 ATPlike Active DFGin 5.8995 13.1635 BLAminus -138.79, 176.44 54.89, 86.07 -89.1, 7.67 290.95, 62.79 -41.83, -37.01 in-in in 8.1848 Saltbr-in 3.1954 HRD-in -79.11, -50.37 72.48, -21.93 in-in-in SNCiii in-in ActLoopNT-in 2.8194 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.28, 123.46 APE9-dihe-na 160.31, -160.86 APE8-dihe-in -110.49, 124.04 APE8-rot-in 311.35 APE67-dihe-in -70.47, -24.34 -45.9, -42.95 APE12-dist-in 8.1626 APE11-dist-in 10.628 APE10-dist-in 5.0018 APE9-dist-in 4.2619 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.56 0.269 0.322 C 350.0 338.0 0 25 25 0 [[44, 298]] 1.0 5jr7 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 7UJXE P05132 16 351 351.0 ADP:60401 ATPlike Active DFGin 5.731 14.3568 BLAminus -121.93, 179.51 64.92, 83.56 -91.91, 29.5 277.22, 63.03 -64.62, -28.12 in-in in 9.1028 Saltbr-in 2.8121 HRD-in -86.19, -57.72 74.11, 16.74 in-in-in SNCiii in-in ActLoopNT-in 2.9312 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.48, 155.47 APE9-dihe-na 127.23, -161.98 APE8-dihe-in -111.77, 133.52 APE8-rot-in 302.04 APE67-dihe-in -65.07, -18.97 -50.87, -44.77 APE12-dist-in 8.1906 APE11-dist-in 11.5001 APE10-dist-in 5.9613 APE9-dist-in 4.0077 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.4 0.133 0.176 E 350.0 336.0 0 25 25 0 [[44, 298]] 1.0 7ujx Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 7V0GE P05132 17 351 351.0 ADP:60401 ATPlike Active DFGin 5.7389 14.3189 BLAminus -119.5, 177.58 67.43, 82.74 -91.45, 25.21 276.8, 64.92 -62.46, -26.34 in-in in 9.0699 Saltbr-in 2.8017 HRD-in -88.93, -50.41 71.3, 15.33 in-in-in SNCiii in-in ActLoopNT-in 2.9568 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.52, 156.77 APE9-dihe-na 130.04, -162.37 APE8-dihe-in -114.97, 131.2 APE8-rot-in 299.52 APE67-dihe-in -60.0, -22.75 -47.18, -49.61 APE12-dist-in 8.1738 APE11-dist-in 11.5422 APE10-dist-in 6.0368 APE9-dist-in 3.9649 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.63 0.118 0.163 E 350.0 335.0 0 25 25 0 [[44, 298]] 1.0 7v0g Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IADA P05132 15 351 351.0 ADP:60403 ATPlike Active DFGin 5.6579 14.362 BLAminus -130.04, -179.13 63.0, 77.66 -87.34, 22.78 276.11, 53.54 -55.12, -31.28 in-in in 9.0855 Saltbr-in 2.8296 HRD-in -93.22, -52.19 70.15, 14.14 in-in-in SNCiii in-in ActLoopNT-in 2.9352 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.54, 160.6 APE9-dihe-na 133.65, -143.98 APE8-dihe-in -130.05, 134.5 APE8-rot-in 298.49 APE67-dihe-in -67.08, -22.74 -48.94, -44.54 APE12-dist-in 8.0511 APE11-dist-in 11.5496 APE10-dist-in 6.0873 APE9-dist-in 3.5214 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.9 0.189 0.243 A 356.0 337.0 0 25 25 0 [[44, 298]] 1.0 4iad Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IAFA P05132 16 351 351.0 ADP:60403 ATPlike Active DFGin 5.9427 14.1301 BLAminus -121.29, 178.82 64.06, 84.8 -98.0, 27.2 281.56, 65.38 -51.93, -33.25 in-in in 8.8711 Saltbr-in 2.6687 HRD-in -76.48, -53.65 65.3, 9.94 in-in-in SNCiii in-in ActLoopNT-in 2.9738 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.4, 160.11 APE9-dihe-na 128.66, -151.44 APE8-dihe-in -123.86, 135.06 APE8-rot-in 298.27 APE67-dihe-in -57.84, -25.84 -42.55, -55.44 APE12-dist-in 8.1629 APE11-dist-in 11.523 APE10-dist-in 5.9727 APE9-dist-in 3.5632 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.2 0.16 0.192 A 356.0 336.0 0 25 25 0 [[44, 298]] 1.0 4iaf Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IAIA P05132 16 351 351.0 ADP:60403 ATPlike Active DFGin 5.4651 14.5028 BLAminus -125.1, 176.4 64.24, 81.88 -90.74, 22.64 269.91, 49.4 -55.45, -35.99 in-in in 9.1007 Saltbr-in 2.7138 HRD-in -91.06, -49.32 68.79, 15.16 in-in-in SNCiii in-in ActLoopNT-in 2.9385 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.75, 156.86 APE9-dihe-na 141.29, -148.36 APE8-dihe-in -128.24, 130.8 APE8-rot-in 300.02 APE67-dihe-in -62.27, -23.0 -47.39, -47.75 APE12-dist-in 7.9453 APE11-dist-in 11.4584 APE10-dist-in 5.8673 APE9-dist-in 3.6084 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.55 0.171 0.209 A 356.0 336.0 0 25 25 0 [[44, 298]] 1.0 4iai Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IAKA P05132 15 351 351.0 ADP:60403 ATPlike Active DFGin 5.7052 14.5691 BLAminus -126.92, 179.61 63.08, 81.74 -90.27, 23.65 270.26, 53.44 -59.05, -31.45 in-in in 8.9848 Saltbr-in 2.7471 HRD-in -94.54, -49.89 67.85, 16.15 in-in-in SNCiii in-in ActLoopNT-in 2.9098 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.92, 164.74 APE9-dihe-na 131.87, -148.57 APE8-dihe-in -130.85, 127.67 APE8-rot-in 297.68 APE67-dihe-in -61.28, -21.91 -43.91, -50.7 APE12-dist-in 7.9618 APE11-dist-in 11.4433 APE10-dist-in 5.9794 APE9-dist-in 3.5447 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.6 0.185 0.222 A 356.0 337.0 0 25 25 0 [[44, 298]] 1.0 4iak Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IAYA P05132 16 351 351.0 ADP:60403 ATPlike Active DFGin 5.806 14.2571 BLAminus -131.74, 174.05 67.76, 85.89 -95.28, 20.31 273.12, 61.73 -48.17, -36.05 in-in in 9.0392 Saltbr-in 2.9406 HRD-in -89.87, -50.65 68.98, 10.01 in-in-in SNCiii in-in ActLoopNT-in 3.055 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.39, 159.46 APE9-dihe-na 132.54, -148.24 APE8-dihe-in -127.91, 130.95 APE8-rot-in 300.76 APE67-dihe-in -63.09, -19.35 -45.58, -49.88 APE12-dist-in 8.0893 APE11-dist-in 11.4657 APE10-dist-in 5.991 APE9-dist-in 3.8226 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.0 0.182 0.227 A 356.0 336.0 0 25 25 0 [[44, 298]] 1.0 4iay Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IAZA P05132 15 351 351.0 ADP:60403 ATPlike Active DFGin 6.1438 14.6353 BLAminus -132.33, 171.23 62.84, 84.78 -94.94, 21.85 278.49, 61.31 -54.74, -28.93 in-in in 9.2192 Saltbr-in 2.747 HRD-in -95.03, -54.93 73.76, 14.73 in-in-in SNCiii in-in ActLoopNT-in 3.017 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.57, 164.74 APE9-dihe-na 127.12, -150.82 APE8-dihe-in -127.02, 138.46 APE8-rot-in 303.51 APE67-dihe-in -63.11, -25.72 -51.71, -47.83 APE12-dist-in 7.9634 APE11-dist-in 11.5144 APE10-dist-in 5.9788 APE9-dist-in 3.5741 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.85 0.201 0.248 A 356.0 337.0 0 25 25 0 [[44, 298]] 1.0 4iaz Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IB0A P05132 15 351 351.0 ADP:60403 ATPlike Active DFGin 5.7134 14.4391 BLAminus -123.68, 176.86 65.62, 82.22 -94.42, 18.76 272.15, 51.12 -47.84, -35.86 in-in in 9.0645 Saltbr-in 3.0231 HRD-in -84.67, -55.05 71.31, 12.11 in-in-in SNCiii in-in ActLoopNT-in 2.8861 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.67, 157.49 APE9-dihe-na 139.08, -144.95 APE8-dihe-in -131.16, 131.55 APE8-rot-in 306.17 APE67-dihe-in -61.31, -24.54 -46.0, -48.78 APE12-dist-in 8.0592 APE11-dist-in 11.5164 APE10-dist-in 5.9694 APE9-dist-in 3.6924 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.87 0.219 0.287 A 356.0 337.0 0 25 25 0 [[44, 298]] 1.0 4ib0 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IB1A P05132 14 351 351.0 ADP:60403 ATPlike Active DFGin 5.6556 14.4434 BLAminus -126.58, 171.72 66.62, 80.69 -90.79, 23.58 274.18, 53.88 -53.03, -31.34 in-in in 9.1208 Saltbr-in 2.6907 HRD-in -82.93, -51.49 69.93, 14.85 in-in-in SNCiii in-in ActLoopNT-in 2.9803 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.64, 163.58 APE9-dihe-na 133.1, -151.37 APE8-dihe-in -125.38, 138.08 APE8-rot-in 304.1 APE67-dihe-in -60.15, -23.69 -50.01, -49.7 APE12-dist-in 7.9604 APE11-dist-in 11.404 APE10-dist-in 5.9611 APE9-dist-in 3.6354 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.63 0.196 0.223 A 356.0 338.0 0 25 25 0 [[44, 298]] 1.0 4ib1 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4IB3A P05132 13 351 351.0 ADP:60401 ATPlike Active DFGin 5.973 14.2146 BLAminus -125.69, 173.12 66.37, 84.97 -98.59, 21.41 276.57, 60.51 -51.27, -29.52 in-in in 8.9902 Saltbr-in 2.7598 HRD-in -77.27, -49.79 61.58, 13.48 in-in-in SNCiii in-in ActLoopNT-in 2.8695 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.06, 160.46 APE9-dihe-na 127.6, -161.57 APE8-dihe-in -110.98, 129.89 APE8-rot-in 305.68 APE67-dihe-in -58.89, -23.07 -39.61, -54.94 APE12-dist-in 8.0781 APE11-dist-in 11.5224 APE10-dist-in 5.9229 APE9-dist-in 3.5677 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.2 0.182 0.228 A 356.0 339.0 0 25 25 0 [[44, 298]] 1.0 4ib3 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4XW6A P05132 15 351 351.0 ADP:60403 ATPlike Active DFGin 5.9823 14.431 BLAminus -130.68, 178.48 65.03, 84.15 -99.24, 23.41 276.01, 56.03 -60.45, -23.49 in-in in 9.1497 Saltbr-in 2.7348 HRD-in -94.59, -52.61 68.2, 15.9 in-in-in SNCiii in-in ActLoopNT-in 2.7909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.91, 154.59 APE9-dihe-na 136.7, -154.91 APE8-dihe-in -121.39, 127.95 APE8-rot-in 293.9 APE67-dihe-in -62.75, -24.38 -45.59, -46.76 APE12-dist-in 8.0512 APE11-dist-in 11.6319 APE10-dist-in 6.051 APE9-dist-in 3.787 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.9 0.186 0.265 A 356.0 337.0 0 25 25 0 [[44, 298]] 1.0 4xw6 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 6E21A P05132 16 351 351.0 ADP:60403 ATPlike Active DFGin 5.5937 14.0551 BLAminus -122.61, 176.37 63.02, 83.41 -94.2, 28.27 284.3, 46.09 -48.88, -41.13 in-in in 9.0287 Saltbr-in 2.6073 HRD-in -74.35, -56.8 67.48, 11.51 in-in-in SNCiii in-in ActLoopNT-in 2.9072 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.7, 159.01 APE9-dihe-na 131.41, -152.84 APE8-dihe-in -125.29, 130.56 APE8-rot-in 303.23 APE67-dihe-in -58.42, -25.04 -35.36, -60.06 APE12-dist-in 8.0433 APE11-dist-in 11.5842 APE10-dist-in 6.0224 APE9-dist-in 3.5802 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.0 0.187 0.217 A 356.0 336.0 0 25 25 0 [[44, 298]] 1.0 6e21 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 1JBPE P05132 10 351 351.0 ADP:60381 ATPlike Inactive DFGin 6.1283 14.0345 BLAminus -131.98, 178.81 60.97, 83.81 -101.93, 15.49 276.81, 71.17 -55.35, -24.18 in-in in 8.8688 Saltbr-in 2.7492 HRD-out -93.99, 130.53 -128.02, 39.83 in-in-in SNCiii in-in ActLoopNT-in 2.8856 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.07, 156.95 APE9-dihe-na 132.9, -168.64 APE8-dihe-in -109.4, 126.7 APE8-rot-in 297.85 APE67-dihe-in -61.28, -20.5 -33.82, -53.02 APE12-dist-in 8.1215 APE11-dist-in 11.4477 APE10-dist-in 6.0125 APE9-dist-in 3.8617 None SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.2 0.175 999.0 E 350.0 342.0 0 25 25 0 [[44, 298]] 1.0 1jbp Mus musculus AGC_PRKACA_MOUSE AGC 1.6e-94 321.9 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 1RDQE P05132 2 351 351.0 ADP:60599,ATP:60600 ATPlike,ATPlike Active DFGin 5.7065 14.5148 BLAminus -117.27, 178.71 64.74, 81.19 -90.07, 21.82 270.96, 52.48 -58.25, -31.62 in-in in 9.0905 Saltbr-in 2.719 HRD-in -91.16, -53.36 73.19, 12.39 in-in-in SNCiii in-in ActLoopNT-in 2.9357 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.91, 159.57 APE9-dihe-na 132.64, -151.85 APE8-dihe-in -127.7, 133.09 APE8-rot-in 298.45 APE67-dihe-in -59.33, -27.24 -47.42, -47.34 APE12-dist-in 8.1158 APE11-dist-in 11.4138 APE10-dist-in 5.8307 APE9-dist-in 3.5208 Y205A TPO198,SEP339 TPO198,SEP339 XRAY 1.26 0.132 0.162 E 350.0 342.0 0 25 25 0 [[44, 298]] 1.0 1rdq Mus musculus AGC_PRKACA_MOUSE AGC 1.1e-92 315.9 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4NTTA P05132 11 351 351.0 ADP:60401 ATPlike Inactive DFGin 6.2546 15.2208 None 58.0, -132.96 -135.23, 163.83 -122.73, 17.77 281.43, 74.72 -41.46, -50.2 in-out in 9.9815 Saltbr-out 4.1938 HRD-in -65.11, -40.77 60.9, 3.38 out-in-in SNCoii in-in ActLoopNT-in 2.8637 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.9, 118.31 APE9-dihe-na 164.12, -173.28 APE8-dihe-in -108.19, 123.7 APE8-rot-in 267.93 APE67-dihe-in -75.4, -22.82 -40.35, -37.34 APE12-dist-in 8.1876 APE11-dist-in 11.1589 APE10-dist-in 5.5421 APE9-dist-in 4.3211 None TPO198,SEP339 TPO198,SEP339 XRAY 3.5 0.23 0.284 A 350.0 341.0 0 25 25 0 [[44, 298]] 1.0 4ntt Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CAMK CAMK2A KCC2A_MOUSE 7B57B P11798 5 307 478.0 ADP:603 ATPlike Active DFGin 6.6116 14.0811 BLAminus -127.42, 175.73 58.47, 86.34 -93.82, 26.41 288.57, 77.62 -63.18, -29.51 in-in in 8.7899 Saltbr-in 2.7985 HRD-in -66.41, -49.66 65.98, 1.57 in-in-in SNCiii in-in ActLoopNT-in 2.9327 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.13, 142.7 APE9-dihe-na 131.67, 177.43 APE8-dihe-in -91.43, 131.98 APE8-rot-in 302.75 APE67-dihe-in -62.31, -16.39 -48.04, -47.99 APE12-dist-in 10.3678 APE11-dist-in 11.4404 APE10-dist-in 5.7432 APE9-dist-in 3.9985 T305A,T306A None None XRAY 1.95 0.206 0.247 B 317.0 303.0 0 28 28 0 [[13, 271]] 1.0 7b57 Mus musculus CAMK_CAMK2A_MOUSE CAMK 1.7e-96 328.6 1.0 256.0 256.0 155 156 157 159 161 42 60 64 132 134 133 135.0 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CK1 CSNK1D KC1D_MOUSE 5X17A Q9DC28 3 292 415.0 ADP:307 Type1.5_Back Active DFGin 5.8854 15.0171 BLAminus -136.76, 176.51 70.17, 78.89 -96.78, 24.57 288.71, 93.09 -76.8, -15.99 in-in in 8.1025 Saltbr-in 3.1483 HRD-in -73.34, -55.18 81.19, 1.41 in-in-in SNCiii in-in ActLoopNT-in 2.8237 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -69.47, -59.72 APE9-dihe-na -86.86, -154.47 APE8-dihe-in -76.87, 120.04 APE8-rot-in 308.55 APE67-dihe-in -51.63, -37.36 -55.73, -38.13 APE12-dist-in 10.4574 APE11-dist-in 12.4167 APE10-dist-in 6.3785 APE9-dist-in 3.8068 None None None XRAY 2.0 0.19 0.242 A 296.0 290.0 0 35 35 0 [[9, 275]] 1.0 5x17 Mus musculus CK1_CSNK1D_MOUSE CK1 1.6e-122 413.9 1.0 262.0 262.0 148 149 150 152 154 38 52 56 125 127 126 128.0 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CK1 CSNK1D KC1D_MOUSE 5X17B Q9DC28 4 292 415.0 ADP:306 Type1.5_Back Active DFGin 6.3327 14.9893 BLAminus -121.28, -179.96 69.25, 82.44 -101.59, 21.98 290.59, 89.01 -77.86, -17.5 in-in in 8.0416 Saltbr-in 3.1065 HRD-in -90.58, -48.35 72.79, 12.65 in-in-in SNCiii in-in ActLoopNT-in 2.7599 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.44, 137.77 APE9-dihe-na 91.26, -171.32 APE8-dihe-in -91.08, 137.89 APE8-rot-in 301.79 APE67-dihe-in -58.2, -31.0 -69.62, -39.78 APE12-dist-in 12.2973 APE11-dist-in 11.9873 APE10-dist-in 6.4915 APE9-dist-in 3.3728 None None None XRAY 2.0 0.19 0.242 B 296.0 289.0 0 35 35 0 [[9, 275]] 1.0 5x17 Mus musculus CK1_CSNK1D_MOUSE CK1 1.6e-122 413.9 1.0 262.0 262.0 148 149 150 152 154 38 52 56 125 127 126 128.0 195 183 178 177 176 175 174 173 172 83 Casein kinase I isoform delta
CMGC GSK3B GSK3B_MOUSE 8VMFA Q9WV60 27 383 420.0 ADP:60504 ATPlike Active DFGin 6.6121 14.0996 BLAminus -148.4, -167.57 58.53, 66.72 -90.57, 24.21 287.49, 78.37 -75.04, -7.89 in-in in 8.6601 Saltbr-in 2.678 HRD-in -67.34, -47.3 70.6, 6.45 in-in-in SNCiii in-in ActLoopNT-in 2.8401 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -98.01, -20.74 APE9-dihe-na -93.16, -168.14 APE8-dihe-in -112.8, 164.36 APE8-rot-in 304.6 APE67-dihe-inflip 78.98, -8.38 -56.8, 140.56 APE12-dist-in 13.183 APE11-dist-in 10.9487 APE10-dist-in 6.514 APE9-dist-in 3.3085 None None None XRAY 2.5 0.21 0.251 A 364.0 354.0 0 27 27 0 [[56, 340]] 1.0 8vmf Mus musculus CMGC_GSK3B_MOUSE CMGC 2e-70 243.5 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_MOUSE 8VMGA Q9WV60 26 383 420.0 ADP:60401 ATPlike Active DFGin 7.0002 13.9987 BLAminus -139.67, -176.86 60.44, 73.06 -89.27, 27.07 283.1, 81.19 -73.23, -12.63 in-in in 8.478 Saltbr-in 2.6881 HRD-in -67.64, -48.38 72.75, 3.36 in-in-in SNCiii in-in ActLoopNT-in 2.8435 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.26, 164.63 APE9-dihe-na 72.45, 142.8 APE8-dihe-in -66.41, 146.08 APE8-rot-in 307.07 APE67-dihe-in -64.3, -22.81 -57.43, -46.54 APE12-dist-in 13.2782 APE11-dist-in 11.627 APE10-dist-in 6.9412 APE9-dist-in 2.9838 None None None XRAY 2.45 0.195 0.23 A 364.0 358.0 0 27 27 0 [[56, 340]] 1.0 8vmg Mus musculus CMGC_GSK3B_MOUSE CMGC 2e-70 243.5 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_MOUSE 8VMEA Q9WV60 26 383 420.0 ADP:60401 ATPlike Active DFGin 6.469 13.8439 BLAminus -131.0, -171.33 63.41, 73.0 -92.56, 22.88 289.27, 83.61 -79.03, -1.02 in-in in 8.7532 Saltbr-in 2.7802 HRD-in -67.9, -47.67 70.4, 7.52 in-in-in SNCiii in-in ActLoopNT-in 2.7313 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -121.18, 168.01 APE9-dihe-na 68.83, 161.19 APE8-dihe-in -90.7, 152.54 APE8-rot-in 290.93 APE67-dihe-inflip 82.32, -22.26 -51.38, 150.9 APE12-dist-in 13.2878 APE11-dist-in 12.0712 APE10-dist-in 6.9342 APE9-dist-in 3.2916 None None None XRAY 2.3 0.183 0.23 A 365.0 355.0 0 27 27 0 [[56, 340]] 1.0 8vme Mus musculus CMGC_GSK3B_MOUSE CMGC 2.1e-70 243.5 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_MOUSE 4NU1A Q9WV60 6 383 420.0 ADP:405 ATPlike Active DFGin 6.1094 13.6771 BLAminus -140.27, -172.8 60.29, 88.19 -108.14, 24.39 289.57, 88.21 -68.01, -14.99 in-in in 8.691 Saltbr-in 2.7928 HRD-in -66.76, -45.51 62.96, 19.85 in-in-in SNCiii in-in ActLoopNT-in 2.6824 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.38, 172.68 APE9-dihe-na 66.76, 153.81 APE8-dihe-in -82.08, 156.46 APE8-rot-in 299.93 APE67-dihe-inflip 76.53, -25.22 -54.39, 158.45 APE12-dist-in 13.5101 APE11-dist-in 11.6207 APE10-dist-in 7.1263 APE9-dist-in 3.1496 None SEP9 SEP9 XRAY 2.5 0.194 0.245 A 389.0 357.0 2 27 27 0 [[56, 340]] 1.0 4nu1 Mus musculus CMGC_GSK3B_MOUSE CMGC 2.5e-70 243.2 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
OTHER ERN1 ERN1_MOUSE 4PL4B Q9EQY0 562 963 977.0 ADP:1001 ATPlike Inactive DFGin 7.3927 13.4972 BLBplus -131.17, -171.5 49.73, 22.15 -77.96, 172.77 53.0, 89.01 68.36, -18.97 out-out out 16.1855 Saltbr-out 12.8674 HRD-in -71.43, -56.11 80.63, -15.27 out-out-out SNCooo out-out ActLoopNT-out 10.3004 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -71.5, 161.7 APE9-dihe-na 95.56, 170.85 APE8-dihe-in -126.15, 140.57 APE8-rot-in 313.23 APE67-dihe-inflip 115.41, -9.81 -59.18, 119.64 APE12-dist-none 999.0 APE11-dist-in 13.3728 APE10-dist-out 8.9632 APE9-dist-in 3.3017 N772Y None None XRAY 3.0 0.213 0.276 B 435.0 384.0 18 31 19 12 [[571, 832]] 1.0 4pl4 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL4C Q9EQY0 562 963 977.0 ADP:1001 ATPlike Inactive DFGin 7.5482 14.2484 BLBplus -126.51, -173.84 57.1, 11.03 -79.33, 148.55 56.35, 128.67 90.22, -11.73 out-out out 16.9717 Saltbr-out 13.4493 HRD-in -87.09, -33.21 64.61, -28.11 out-out-out SNCooo out-out ActLoopNT-out 10.6681 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioi APE10-dihe-na -75.07, 168.04 APE9-dihe-na 83.31, 160.45 APE8-dihe-in -117.06, 150.3 APE8-rot-out 84.63 APE67-dihe-inflip 114.33, -11.46 -59.41, 124.52 APE12-dist-none 999.0 APE11-dist-in 13.4836 APE10-dist-out 8.4493 APE9-dist-in 3.5542 N772Y None None XRAY 3.0 0.213 0.276 C 435.0 384.0 18 31 19 12 [[571, 832]] 1.0 4pl4 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL4D Q9EQY0 562 961 977.0 ADP:1001 ATPlike Inactive DFGin 7.5079 13.71 BLBplus -135.47, -173.14 51.5, 21.77 -87.04, 144.38 56.66, 114.14 91.93, -17.13 out-out out 15.9791 Saltbr-out 13.3396 HRD-in -83.86, -32.09 72.35, -48.88 out-out-out SNCooo out-out ActLoopNT-out 10.328 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -70.73, 154.49 APE9-dihe-na 96.39, -168.63 APE8-dihe-in -140.56, 130.56 APE8-rot-in 311.25 APE67-dihe-inflip 116.72, -15.16 -51.06, 117.77 APE12-dist-none 999.0 APE11-dist-in 13.9703 APE10-dist-out 9.1376 APE9-dist-in 3.9224 N772Y None None XRAY 3.0 0.213 0.276 D 435.0 377.0 18 31 19 12 [[571, 832]] 1.0 4pl4 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL5B Q9EQY0 562 963 977.0 ADP:1001 ATPlike Inactive DFGin 7.4546 13.9365 BLBplus -129.37, -173.23 56.7, 18.18 -83.15, 166.18 46.51, 88.1 78.73, -17.65 out-out out 17.3785 Saltbr-out 14.0508 HRD-in -57.7, -43.88 69.49, -15.96 out-out-out SNCooo out-out ActLoopNT-out 10.0479 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_nioi APE10-dihe-na -68.77, 169.09 APE9-dihe-na 94.26, -167.14 APE8-dihe-in -147.72, 134.59 APE8-rot-in 292.91 APE67-dihe-out 142.49, -27.58 -41.24, 92.94 APE12-dist-none 999.0 APE11-dist-in 13.2922 APE10-dist-out 8.4459 APE9-dist-in 3.3559 N772Y None None XRAY 3.4 0.225 0.285 B 435.0 383.0 19 31 18 13 [[571, 832]] 1.0 4pl5 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL5C Q9EQY0 562 963 977.0 ADP:1001 ATPlike Inactive DFGin 7.7942 14.0613 BLBplus -140.3, -178.86 59.78, 31.79 -102.25, 171.48 50.28, 80.31 73.36, 0.55 out-out out 16.8522 Saltbr-out 12.6343 HRD-in -71.26, -29.05 67.43, -40.0 out-out-out SNCooo out-out ActLoopNT-out 10.5425 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -68.61, -176.62 APE9-dihe-na 79.33, -164.24 APE8-dihe-in -141.99, 145.59 APE8-rot-in 309.7 APE67-dihe-inflip 125.8, -7.43 -55.77, 102.3 APE12-dist-none 999.0 APE11-dist-in 13.6845 APE10-dist-out 8.5993 APE9-dist-in 3.6488 N772Y None None XRAY 3.4 0.225 0.285 C 435.0 386.0 16 31 20 11 [[571, 832]] 1.0 4pl5 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL5D Q9EQY0 561 963 977.0 ADP:1001 ATPlike Inactive DFGin 6.8833 13.7093 BLBplus -149.88, 177.73 60.77, 34.53 -99.83, 170.66 50.74, 82.52 85.0, -30.32 out-out out 16.8731 Saltbr-out 16.3097 HRD-in -73.87, -31.52 63.42, -30.41 out-out-out SNCooo out-out ActLoopNT-out 10.8618 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nioi APE10-dihe-na -64.48, 167.99 APE9-dihe-na 99.63, 173.49 APE8-dihe-in -124.29, 140.67 APE8-rot-out 174.47 APE67-dihe-inflip 122.64, -17.06 -61.26, 114.95 APE12-dist-none 999.0 APE11-dist-in 13.2318 APE10-dist-out 8.1121 APE9-dist-in 3.9187 N772Y None None XRAY 3.4 0.225 0.285 D 435.0 385.0 18 31 19 12 [[571, 832]] 1.0 4pl5 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL3A Q9EQY0 560 964 977.0 31J:1001,ADP:1002 Allosteric,ATPlike Inactive DFGin 7.327 13.7163 BLBplus -137.83, -169.53 45.26, 38.38 -99.01, 160.39 56.61, 78.79 64.67, 4.33 out-out out 16.5791 Saltbr-out 12.4483 HRD-in -67.88, -49.57 75.5, 1.96 out-out-out SNCooo out-out ActLoopNT-out 9.693 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -56.59, -179.83 APE9-dihe-na 70.82, 169.1 APE8-dihe-in -122.85, 127.5 APE8-rot-in 297.91 APE67-dihe-inflip 117.64, -32.26 -39.31, 118.58 APE12-dist-none 999.0 APE11-dist-out 14.0611 APE10-dist-out 9.3121 APE9-dist-in 3.5586 N772Y None None XRAY 2.9 0.202 0.234 A 435.0 388.0 17 31 19 12 [[571, 832]] 1.0 4pl3 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL3B Q9EQY0 562 963 977.0 31J:1001,ADP:1002 Allosteric,ATPlike Inactive DFGin 7.3343 13.8933 BLBplus -148.72, -173.45 55.21, 14.76 -81.6, 169.54 60.69, 84.7 79.59, -5.1 out-out out 16.5804 Saltbr-out 13.2885 HRD-in -77.64, -56.6 82.71, -30.85 out-out-out SNCooo out-out ActLoopNT-out 10.6216 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -64.56, 166.09 APE9-dihe-na 91.33, -176.0 APE8-dihe-in -135.33, 135.79 APE8-rot-in 299.82 APE67-dihe-inflip 121.38, -25.98 -48.92, 119.9 APE12-dist-none 999.0 APE11-dist-out 14.1225 APE10-dist-out 9.3359 APE9-dist-in 3.6949 N772Y None None XRAY 2.9 0.202 0.234 B 435.0 383.0 19 31 18 13 [[571, 832]] 1.0 4pl3 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL4A Q9EQY0 562 963 977.0 31K:1001,ADP:1002 Allosteric,ATPlike Inactive DFGin 6.7883 14.2186 BLBplus -105.14, -174.11 44.38, 29.11 -94.38, 143.46 69.8, 104.54 103.76, -33.08 out-out out 16.6052 Saltbr-out 13.2732 HRD-in -77.26, -47.59 71.94, -10.31 out-out-out SNCooo out-out ActLoopNT-out 10.5629 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -61.91, 153.92 APE9-dihe-na 102.53, -174.53 APE8-dihe-in -133.87, 129.13 APE8-rot-in 297.04 APE67-dihe-inflip 119.89, -24.27 -52.28, 118.86 APE12-dist-none 999.0 APE11-dist-out 14.3788 APE10-dist-out 9.4324 APE9-dist-in 3.2964 N772Y None None XRAY 3.0 0.213 0.276 A 435.0 385.0 17 31 20 11 [[571, 832]] 1.0 4pl4 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER ERN1 ERN1_MOUSE 4PL5A Q9EQY0 562 964 977.0 31L:1001,ADP:1002,PEU:1004 Allosteric,ATPlike,Allosteric Inactive DFGin 6.5845 13.7552 BLBplus -127.28, -167.94 47.08, 28.46 -89.65, 160.5 62.46, 164.78 70.79, 0.93 out-out out 16.2962 Saltbr-out 12.729 HRD-in -75.22, -42.28 71.55, -19.88 out-out-out SNCooo out-out ActLoopNT-out 10.4865 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioi APE10-dihe-na -69.09, -179.67 APE9-dihe-na 72.79, -173.9 APE8-dihe-in -128.85, 142.84 APE8-rot-in 291.98 APE67-dihe-inflip 114.76, -25.15 -48.2, 123.54 APE12-dist-none 999.0 APE11-dist-in 13.7986 APE10-dist-out 8.5968 APE9-dist-in 3.4978 N772Y None None XRAY 3.4 0.225 0.285 A 435.0 386.0 17 31 19 12 [[571, 832]] 1.0 4pl5 Mus musculus OTHER_ERN1_MOUSE CAMK 3.2e-35 128.2 5.0 256.0 252.0 710 711 712 714 716 599 612 616 685 687 686 688.0 756 741 736 735 734 733 732 731 730 643 Serine/threonine-protein kinase/endoribonuclease IRE1
TYR EPHB2 EPHB2_MOUSE 2HENA P54763 614 893 986.0 ADP:60400 ATPlike None DFGin 5.3332 15.674 BLAminus -133.74, -165.91 59.29, 70.83 -103.82, 9.51 292.63, 82.7 -87.21, 999.0 in-in in 8.0233 Saltbr-in 2.7858 HRD-in -62.88, -49.36 74.49, -21.92 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 78.77 APE8-rot-na 327.53 APE67-dihe-in -57.52, -8.41 -44.64, -64.96 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 D746A None None XRAY 2.6 0.205 0.26 A 286.0 258.0 22 33 11 22 [[621, 882]] 1.0 2hen Mus musculus TYR_EPHB2_MOUSE TYR 7e-108 365.8 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR EPHB2 EPHB2_MOUSE 2HENB P54763 614 893 986.0 ADP:60401 ATPlike None DFGin 4.8756 14.8878 BLAminus -140.27, -169.83 69.21, 92.69 -125.5, 35.8 302.49, 84.21 -59.5, 999.0 in-in in 8.2673 Saltbr-in 2.8391 HRD-in -71.96, -52.85 76.51, -19.64 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 70.95 APE8-rot-na 35.68 APE67-dihe-in -63.04, 8.29 -53.0, -58.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 D746A None None XRAY 2.6 0.205 0.26 B 286.0 258.0 22 33 11 22 [[621, 882]] 1.0 2hen Mus musculus TYR_EPHB2_MOUSE TYR 7e-108 365.8 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR EPHB2 EPHB2_MOUSE 2HENC P54763 614 893 986.0 ADP:60402 ATPlike None DFGin 5.1672 15.7873 BLAminus -136.6, -161.63 61.14, 70.93 -108.31, 8.65 286.35, 98.46 -79.82, 999.0 in-in in 8.0738 Saltbr-in 2.8762 HRD-in -60.04, -43.18 71.33, -24.11 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 75.37 APE8-rot-na 329.62 APE67-dihe-in -67.84, -7.2 -58.96, -40.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 D746A None None XRAY 2.6 0.205 0.26 C 286.0 258.0 22 33 11 22 [[621, 882]] 1.0 2hen Mus musculus TYR_EPHB2_MOUSE TYR 7e-108 365.8 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR EPHB2 EPHB2_MOUSE 2HEND P54763 614 893 986.0 ADP:60403 ATPlike None DFGin 4.7905 14.7722 BLAminus -150.33, -176.71 75.96, 94.04 -126.18, 89.85 307.58, 79.07 -67.67, 999.0 in-in in 8.3217 Saltbr-in 3.4086 HRD-in -71.43, -49.79 75.74, -24.02 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 92.49 APE8-rot-na 333.13 APE67-dihe-in -68.61, 6.13 -48.05, -54.94 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 D746A None None XRAY 2.6 0.205 0.26 D 286.0 258.0 22 33 11 22 [[621, 882]] 1.0 2hen Mus musculus TYR_EPHB2_MOUSE TYR 7e-108 365.8 2.0 261.0 260.0 763 764 765 767 769 653 670 674 743 745 744 746.0 808 796 791 790 789 788 787 786 785 700 Ephrin type-B receptor 2
TYR JAK1-12 JAK1_MOUSE 7T6FA P52332 32 1153 1153.0 ADN:61201,ADP:61202 Allosteric,ATPlike Inactive DFGin 6.8989 13.8131 None -86.13, -125.98 -78.37, 170.67 -132.74, 42.36 300.4, 95.7 -63.52, -44.16 in-out in 8.2656 Saltbr-out 5.3454 HRD-in -74.55, -24.53 68.9, -7.15 out-in-out SNCoio in-out ActLoopNT-in 3.3664 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -74.97, -30.61 APE9-dihe-in -69.86, 145.09 APE8-dihe-in -65.5, 154.45 APE8-rot-na 337.81 APE67-dihe-in -111.81, 34.03 -69.03, -47.03 APE12-dist-na 13.0701 APE11-dist-na 13.989 APE10-dist-na 8.6737 APE9-dist-in 6.36 None None None EM 3.6 999.0 999.0 A 1173.0 1043.0 23 31 31 0 [[582, 846], [874, 1150]] 2.0 7t6f Mus musculus TYR_JAK1-12_MOUSE TYR 7.5e-59 499.6 3.0 260.0 516.0 1019 1020 1021 1023 1025 907 924 928 999 1001 1000 1002.0 1062 1050 1045 1044 1043 1042 1041 1040 1039 956 Tyrosine-protein kinase JAK1
TYR JAK1-12 JAK1_MOUSE 7T6FB P52332 32 1153 1153.0 ADN:61201,ADP:61202 Allosteric,ATPlike Inactive DFGin 6.8984 13.8132 None -86.09, -125.95 -78.45, 170.72 -132.73, 42.29 300.45, 95.61 -63.42, -44.2 in-out in 8.2667 Saltbr-out 5.3471 HRD-in -74.65, -24.42 68.9, -7.11 out-in-out SNCoio in-out ActLoopNT-in 3.3661 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -74.91, -30.65 APE9-dihe-in -69.79, 145.09 APE8-dihe-in -65.5, 154.47 APE8-rot-na 337.81 APE67-dihe-in -111.9, 34.05 -69.03, -46.98 APE12-dist-na 13.0694 APE11-dist-na 13.9887 APE10-dist-na 8.6729 APE9-dist-in 6.3604 None None None EM 3.6 999.0 999.0 B 1173.0 1043.0 23 31 31 0 [[582, 846], [874, 1150]] 2.0 7t6f Mus musculus TYR_JAK1-12_MOUSE TYR 7.5e-59 499.6 3.0 260.0 516.0 1019 1020 1021 1023 1025 907 924 928 999 1001 1000 1002.0 1062 1050 1045 1044 1043 1042 1041 1040 1039 956 Tyrosine-protein kinase JAK1
TYR JAK1-12 JAK1_MOUSE 8EWYA P52332 32 1153 1153.0 ADN:61201,ADP:61202 Allosteric,ATPlike Inactive None 999.0 999.0 None -138.68, -158.74 57.84, 53.41 -86.5, 17.2 999.0, 999.0 -66.33, -21.83 in-none in 8.0785 Saltbr-none 999.0 HRD-in -63.86, -38.24 65.99, -1.42 none-in-in SNCnii in-in ActLoopNT-in 2.8414 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.88, 139.03 APE9-dihe-in -137.63, 148.1 APE8-dihe-in -70.82, 80.23 APE8-rot-na 999.0 APE67-dihe-in -71.32, -12.38 -60.07, -30.97 APE12-dist-na 13.0021 APE11-dist-na 7.9281 APE10-dist-na 11.009 APE9-dist-in 6.3419 V657F None None EM 5.5 999.0 999.0 A 1173.0 1047.0 19 31 31 0 [[582, 846], [874, 1150]] 2.0 8ewy Mus musculus TYR_JAK1-12_MOUSE TYR 7.5e-59 499.6 3.0 260.0 516.0 1019 1020 1021 1023 1025 907 924 928 999 1001 1000 1002.0 1062 1050 1045 1044 1043 1042 1041 1040 1039 956 Tyrosine-protein kinase JAK1
TYR JAK1-12 JAK1_MOUSE 8EWYB P52332 32 1153 1153.0 ADN:61201,ADP:61202 Allosteric,ATPlike Inactive None 999.0 999.0 None -138.65, -158.76 57.86, 53.37 -86.37, 17.05 999.0, 999.0 -66.24, -21.9 in-none in 8.0788 Saltbr-none 999.0 HRD-in -63.87, -38.25 66.06, -1.5 none-in-in SNCnii in-in ActLoopNT-in 2.8419 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -64.87, 139.06 APE9-dihe-in -137.62, 148.16 APE8-dihe-in -70.91, 80.26 APE8-rot-na 999.0 APE67-dihe-in -71.25, -12.38 -60.08, -31.01 APE12-dist-na 13.0021 APE11-dist-na 7.9285 APE10-dist-na 11.0086 APE9-dist-in 6.3412 V657F None None EM 5.5 999.0 999.0 B 1173.0 1047.0 19 31 31 0 [[582, 846], [874, 1150]] 2.0 8ewy Mus musculus TYR_JAK1-12_MOUSE TYR 7.5e-59 499.6 3.0 260.0 516.0 1019 1020 1021 1023 1025 907 924 928 999 1001 1000 1002.0 1062 1050 1045 1044 1043 1042 1041 1040 1039 956 Tyrosine-protein kinase JAK1
TYR SRC SRC_MOUSE 8XN8A P05480 85 534 535.0 ADP:601 ATPlike Inactive DFGin 5.8276 13.2331 BLBplus -120.06, 161.26 65.68, 32.74 -74.22, 143.59 39.08, 88.47 84.86, -35.8 out-out out 13.9863 Saltbr-out 13.9219 HRD-in -73.69, -59.12 84.41, -7.57 out-out-out SNCooo out-out ActLoopNT-out 7.4048 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -103.24, -6.02 APE9-dihe-in -94.54, 127.69 APE8-dihe-in -80.44, 65.55 APE8-rot-na 33.74 APE67-dihe-in -67.14, -17.8 -57.51, -33.8 APE12-dist-na 17.6986 APE11-dist-na 18.5584 APE10-dist-na 13.3733 APE9-dist-out 8.7101 None PTR529 PTR529 XRAY 1.95 0.187 0.224 A 451.0 450.0 0 29 29 0 [[269, 520]] 1.0 8xn8 Mus musculus TYR_SRC_MOUSE TYR 8.8e-94 319.8 1.0 260.0 260.0 405 406 407 409 411 297 312 316 385 387 386 388.0 446 434 429 428 427 426 425 424 423 341 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_MOUSE 6F3FA P05480 85 531 535.0 ADP:60601 ATPlike Inactive DFGin 5.729 13.2626 BLBplus -129.36, 166.09 58.36, 35.58 -80.98, 135.75 39.82, 82.45 82.86, -9.54 out-out out 14.175 Saltbr-out 14.398 HRD-in -79.21, -57.39 83.57, -8.9 out-out-out SNCooo out-out ActLoopNT-out 7.2896 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -111.04, 2.76 APE9-dihe-in -98.67, 129.97 APE8-dihe-in -74.19, 70.52 APE8-rot-na 30.31 APE67-dihe-in -76.25, -9.79 -62.62, -30.23 APE12-dist-na 17.5264 APE11-dist-na 18.7227 APE10-dist-na 13.526 APE9-dist-out 8.5478 None PTR529 PTR529 XRAY 2.418 0.211 0.268 A 455.0 447.0 0 29 29 0 [[269, 520]] 1.0 6f3f Mus musculus TYR_SRC_MOUSE TYR 9e-94 319.7 1.0 260.0 260.0 405 406 407 409 411 297 312 316 385 387 386 388.0 446 434 429 428 427 426 425 424 423 341 Proto-oncogene tyrosine-protein kinase Src
OTHER PKNB PKNB_MYCTU 3F61A P9WI81 1 290 626.0 ADP:340 ATPlike Inactive DFGin 10.4084 16.8235 BLBminus -141.07, 168.15 65.97, 58.12 -87.1, 145.62 281.84, 72.93 89.1, 11.07 in-out in 9.9329 Saltbr-out 6.7775 HRD-in -66.51, -54.56 82.27, -14.45 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -63.4, -20.65 999.0, 0.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 L33D,V222D None None XRAY 1.8 0.205 0.228 A 311.0 271.0 19 31 12 19 [[11, 273]] 1.0 3f61 Mycobacterium tuberculosis OTHER_PKNB_MYCTU CAMK 1.6e-46 164.7 1.0 248.0 248.0 155 156 157 159 161 40 59 63 135 137 136 138.0 198 186 181 180 179 178 177 176 175 93 Serine/threonine-protein kinase PknB
OTHER PKNG PKNG_MYCTU 4Y0XA P9WI73 83 404 750.0 ADP:501 ATPlike Inactive DFGin 6.7267 11.5343 BLAminus -117.75, -169.01 53.44, 71.03 -83.15, 12.14 305.33, 8.75 -59.16, -32.06 out-out out 15.116 Saltbr-out 15.0592 HRD-in -73.44, -41.15 68.04, -13.32 out-in-out SNCoio in-out ActLoopNT-in 2.7773 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -55.23, 147.28 APE9-dihe-na -174.26, 176.21 APE8-dihe-in -98.04, 125.35 APE8-rot-in 298.01 APE67-dihe-inflip 105.55, -13.26 -56.87, 129.33 APE12-dist-out 5.5418 APE11-dist-in 10.1536 APE10-dist-in 7.3709 APE9-dist-in 5.7905 None None None XRAY 1.74 0.198 0.209 A 375.0 322.0 0 24 24 0 [[151, 345]] 1.0 4y0x Mycobacterium tuberculosis OTHER_PKNG_MYCTU CAMK 8.2e-22 86.0 1.0 186.0 186.0 292 293 294 296 298 181 198 202 273 275 274 276.0 327 316 311 310 309 308 307 306 305 233 Serine/threonine-protein kinase PknG
OTHER PKNI PKNI_MYCTU 5M06B P9WI69 2 255 585.0 ADP:301 ATPlike Inactive DFGin 8.3159 16.6312 BLBminus -112.52, 166.29 60.43, 51.53 -60.28, 125.48 270.62, 84.02 56.24, 31.01 out-out out 14.989 Saltbr-out 14.3942 HRD-in -80.29, -52.43 77.96, -9.32 out-out-out SNCooo out-out ActLoopNT-out 11.5297 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-out -70.34, -46.82 -66.42, 150.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.213 0.239 B 276.0 248.0 3 14 14 0 [[12, 175]] 1.0 5m06 Mycobacterium tuberculosis OTHER_PKNI_MYCTU CAMK 1.3e-18 76.4 1.0 201.0 201.0 158 159 160 162 164 41 60 64 134 136 135 137.0 184 172 167 166 0 0 0 0 0 90 Serine/threonine-protein kinase PknI
STE MAP2K1 MP2K1_RABIT 7JUQC P29678 40 381 393.0 ADP:401 ATPlike Inactive DFGin 6.5861 14.742 BLBplus -129.84, -170.1 45.36, 32.9 -86.02, 164.53 43.64, 99.66 -81.97, 72.94 out-out out 15.5727 Saltbr-out 14.6393 HRD-in -71.73, -54.6 83.98, -10.27 out-out-out SNCooo out-out ActLoopNT-out 9.8167 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -103.97, 121.68 APE9-dihe-na -107.28, -138.86 APE8-dihe-out -101.2, -25.18 APE8-rot-out 36.43 APE67-dihe-out -125.05, 133.16 -97.84, 131.49 APE12-dist-out 16.4657 APE11-dist-out 18.834 APE10-dist-out 20.472 APE9-dist-out 14.6884 None None None XRAY 3.22 0.256 0.288 C 384.0 305.0 37 26 26 0 [[68, 361]] 1.0 7juq Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
OTHER FLS2 FLS2_ORYSJ 8JUVA Q0JA29 861 1178 1183.0 ADP:60601 ATPlike Inactive DFGin 6.1498 14.3273 BLAminus -130.59, 177.4 65.69, 86.01 -100.39, 23.88 290.69, 79.09 -65.0, -14.14 in-in in 8.0252 Saltbr-in 2.7601 HRD-in -70.78, -47.74 78.11, -0.08 in-in-out SNCiio in-out ActLoopNT-in 2.7474 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -103.82, 168.59 APE9-dihe-na 62.78, -132.62 APE8-dihe-out -74.57, -16.63 APE8-rot-out 44.07 APE67-dihe-in -63.03, -19.63 -66.3, -33.92 APE12-dist-out 23.7254 APE11-dist-out 18.6911 APE10-dist-out 19.68 APE9-dist-out 12.2555 None None MSE903,MSE959,MSE1037,MSE1066,MSE1073,MSE1090,MSE1134,MSE1166,MSE1176 XRAY 2.09 0.183 0.208 A 339.0 288.0 30 39 23 16 [[874, 1175]] 1.0 8juv Oryza sativa OTHER_FLS2_ORYSJ TKL 3.7e-44 157.3 4.0 265.0 262.0 1030 1031 1032 1034 1036 908 926 930 1010 1012 1011 1013.0 1081 1069 1064 1063 1062 1061 1060 1059 1058 957 LRR receptor-like serine/threonine-protein kinase FLS2
OTHER PINK1 PINK1_PEDHC 8UYIA E0W1I1 120 572 575.0 ADP:601 ATPlike Active DFGin 9.4715 14.4921 BLAminus -126.54, -170.24 58.08, 66.04 -87.71, 25.91 289.34, 85.25 -66.89, -21.8 in-in in 7.7338 Saltbr-in 2.4889 HRD-in -72.82, -45.28 62.7, 4.34 in-in-in SNCiii in-in ActLoopNT-in 2.7928 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na 149.48, -127.57 APE9-dihe-na -109.63, -105.35 APE8-dihe-in -70.24, 160.24 APE8-rot-na 51.46 APE67-dihe-in -90.34, -42.74 -107.64, 8.21 APE12-dist-in 8.4846 APE11-dist-in 10.4134 APE10-dist-in 5.8277 APE9-dist-in 3.6425 None SEP202,TPO305 SEP202,TPO305 EM 3.13 999.0 999.0 A 463.0 369.0 49 34 34 0 [[64, 514]] 1.0 8uyi Pediculus humanus OTHER_PINK1_PEDHC PINK1 1e-86 297.1 4.0 367.0 364.0 356 357 358 360 362 193 214 218 331 333 332 334.0 408 390 385 384 383 382 381 380 379 291 Serine/threonine-protein kinase Pink1, mitochondrial
OTHER PINK1 PINK1_PEDHC 8UYIB E0W1I1 122 574 575.0 ADP:601 ATPlike Active DFGin 9.3699 14.7672 BLAminus -128.32, -168.79 58.11, 64.54 -83.54, 12.33 278.78, 92.3 -66.63, -13.93 in-in in 8.0008 Saltbr-in 2.3626 HRD-in -66.42, -44.15 62.85, 2.17 in-in-in SNCiii in-in ActLoopNT-in 2.9742 ActLoopCT-in nonTYR APEdihe_aaiai APEdist_iiii APE10-dihe-na 143.29, -143.85 APE9-dihe-na -111.19, -100.88 APE8-dihe-in -71.36, 134.31 APE8-rot-na 50.34 APE67-dihe-in -67.38, -41.28 -74.79, -24.08 APE12-dist-in 8.4735 APE11-dist-in 10.8064 APE10-dist-in 6.2268 APE9-dist-in 3.5529 None SEP202,TPO305 SEP202,TPO305 EM 3.13 999.0 999.0 B 463.0 369.0 51 34 34 0 [[64, 514]] 1.0 8uyi Pediculus humanus OTHER_PINK1_PEDHC PINK1 1e-86 297.1 4.0 367.0 364.0 356 357 358 360 362 193 214 218 331 333 332 334.0 408 390 385 384 383 382 381 380 379 291 Serine/threonine-protein kinase Pink1, mitochondrial
AGC PRKACA KAPCA_RAT 3TNQB P27791 18 351 351.0 ADP:60400 ATPlike Inactive DFGin 6.0256 14.1092 ABAminus -114.77, -42.68 -116.73, 98.61 -86.63, 16.07 279.08, 57.74 -59.27, -13.09 in-in in 8.7647 Saltbr-in 3.2951 HRD-in -83.62, -53.15 67.05, 14.07 in-in-in SNCiii in-in ActLoopNT-in 3.0146 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.54, 167.18 APE9-dihe-na 139.44, -131.54 APE8-dihe-in -144.99, 127.08 APE8-rot-in 312.05 APE67-dihe-in -55.59, -13.34 -44.48, -54.97 APE12-dist-in 8.0951 APE11-dist-in 11.4567 APE10-dist-in 6.1812 APE9-dist-in 3.5888 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 3.097 0.234 0.275 B 350.0 334.0 0 25 25 0 [[44, 298]] 1.0 3tnq Rattus norvegicus AGC_PRKACA_RAT AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CMGC MAPK1 MK01_RAT 4GVAA P63086 11 356 358.0 ADP:401 ATPlike Inactive DFGin 6.7023 16.7688 BLAminus -137.11, 178.59 63.89, 77.38 -94.14, 25.17 286.58, 79.57 -59.17, -35.22 out-out out 10.4922 Saltbr-out 6.5214 HRD-in -67.64, -55.15 72.72, 9.25 out-in-in SNCoii in-in ActLoopNT-in 2.8301 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -101.68, -13.3 APE9-dihe-na -77.88, 161.53 APE8-dihe-in -56.04, 126.28 APE8-rot-in 320.84 APE67-dihe-in -66.77, -13.08 -47.2, -54.23 APE12-dist-in 13.8449 APE11-dist-in 11.0504 APE10-dist-in 7.1482 APE9-dist-in 4.1983 None None CME159 XRAY 1.83 0.191 0.241 A 364.0 346.0 0 31 31 0 [[23, 311]] 1.0 4gva Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.4e-85 293.1 1.0 301.0 301.0 164 165 166 168 170 52 69 73 144 146 145 147.0 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC FUS3 FUS3_YEAST 2B9HA P16892 1 353 353.0 ADP:500 ATPlike Inactive DFGin 6.2831 13.7635 BLAminus -136.62, -177.7 68.6, 65.84 -94.91, 10.48 297.74, 102.72 -75.81, -10.99 in-in in 8.5638 Saltbr-in 2.7323 HRD-in -74.04, -48.55 74.11, -6.87 in-in-out SNCiio in-out ActLoopNT-in 2.9317 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -116.55, 132.5 APE9-dihe-na -63.29, 147.56 APE8-dihe-in -50.7, 127.74 APE8-rot-in 296.79 APE67-dihe-in -63.13, -20.59 -60.61, -24.81 APE12-dist-in 8.6053 APE11-dist-out 6.693 APE10-dist-out 9.8356 APE9-dist-in 4.7504 T180V,Y182F None None XRAY 1.55 0.187 0.216 A 353.0 337.0 16 38 22 16 [[13, 309]] 1.0 2b9h Saccharomyces cerevisiae CMGC_FUS3_YEAST CMGC 2.2e-73 253.2 3.0 301.0 299.0 154 155 156 158 160 42 59 63 134 136 135 137.0 205 192 187 186 185 184 183 182 181 94 Mitogen-activated protein kinase FUS3
CMGC FUS3 FUS3_YEAST 2B9IA P16892 1 353 353.0 ADP:500 ATPlike Inactive DFGin 6.3651 14.0664 BLAminus -135.63, 178.36 68.62, 72.5 -98.81, 8.36 296.13, 97.35 -58.15, -32.2 in-in in 8.7017 Saltbr-in 2.9495 HRD-in -67.33, -47.39 70.79, -9.55 in-in-out SNCiio in-out ActLoopNT-in 2.9537 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -112.27, 137.29 APE9-dihe-na -73.31, 133.1 APE8-dihe-in -36.03, 128.5 APE8-rot-in 289.53 APE67-dihe-in -68.8, -14.68 -68.0, -19.59 APE12-dist-in 8.9047 APE11-dist-out 6.5806 APE10-dist-out 9.9611 APE9-dist-in 4.5499 T180V,Y182F None None XRAY 2.5 0.202 0.279 A 353.0 338.0 15 38 23 15 [[13, 309]] 1.0 2b9i Saccharomyces cerevisiae CMGC_FUS3_YEAST CMGC 2.2e-73 253.2 3.0 301.0 299.0 154 155 156 158 160 42 59 63 134 136 135 137.0 205 192 187 186 185 184 183 182 181 94 Mitogen-activated protein kinase FUS3
CMGC FUS3 FUS3_YEAST 2B9JA P16892 1 353 353.0 ADP:500 ATPlike Inactive DFGin 6.5469 13.8678 BLAminus -134.9, -176.68 60.68, 67.3 -98.24, 14.73 302.06, 96.25 -69.67, -26.86 in-in in 8.7013 Saltbr-in 2.9604 HRD-in -72.32, -48.06 70.0, -6.29 in-in-out SNCiio in-out ActLoopNT-in 2.9661 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -102.32, 139.79 APE9-dihe-na -71.76, 150.07 APE8-dihe-in -56.91, 118.63 APE8-rot-in 300.43 APE67-dihe-in -59.09, -25.02 -50.5, -31.25 APE12-dist-in 8.8527 APE11-dist-out 6.5935 APE10-dist-out 10.0651 APE9-dist-in 4.7662 T180V,Y182F None None XRAY 2.3 0.196 0.263 A 353.0 337.0 16 38 22 16 [[13, 309]] 1.0 2b9j Saccharomyces cerevisiae CMGC_FUS3_YEAST CMGC 2.2e-73 253.2 3.0 301.0 299.0 154 155 156 158 160 42 59 63 134 136 135 137.0 205 192 187 186 185 184 183 182 181 94 Mitogen-activated protein kinase FUS3
CMGC FUS3 FUS3_YEAST 2B9FA P16892 1 353 353.0 ADP:500 ATPlike Inactive DFGin 6.3195 13.8141 BLAminus -136.19, -174.38 64.52, 61.38 -89.09, 7.19 299.63, 104.82 -67.16, -21.09 in-in in 8.6105 Saltbr-in 2.6835 HRD-in -75.04, -47.21 75.53, -13.96 in-in-out SNCiio in-out ActLoopNT-in 3.0448 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -129.66, 156.16 APE9-dihe-na -66.55, 158.23 APE8-dihe-in -56.07, 140.2 APE8-rot-in 288.73 APE67-dihe-in -58.7, -27.3 -59.52, -33.17 APE12-dist-in 8.6815 APE11-dist-out 5.7984 APE10-dist-out 8.5735 APE9-dist-in 4.0923 None None None XRAY 1.8 0.213 0.259 A 353.0 337.0 16 38 22 16 [[13, 309]] 1.0 2b9f Saccharomyces cerevisiae CMGC_FUS3_YEAST CMGC 5.2e-75 258.5 3.0 301.0 299.0 154 155 156 158 160 42 59 63 134 136 135 137.0 205 192 187 186 185 184 183 182 181 94 Mitogen-activated protein kinase FUS3
CMGC FUS3 FUS3_YEAST 2F9GA P16892 1 353 353.0 ADP:500 ATPlike None DFGin 6.6068 14.0327 BLAminus -131.87, -173.96 62.19, 67.37 -94.01, 7.54 292.42, 102.61 -61.43, -28.32 in-in in 8.7382 Saltbr-in 2.7662 HRD-in -77.05, -50.83 75.67, -3.23 in-in-none SNCiin in-none ActLoopNT-in 2.9552 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.43 APE8-rot-in 296.4 APE67-dihe-in -62.22, -26.66 -58.62, -16.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None PTR182 PTR182 XRAY 2.1 0.211 0.26 A 353.0 332.0 21 38 17 21 [[13, 309]] 1.0 2f9g Saccharomyces cerevisiae CMGC_FUS3_YEAST CMGC 5.2e-75 258.5 3.0 301.0 299.0 154 155 156 158 160 42 59 63 134 136 135 137.0 205 192 187 186 185 184 183 182 181 94 Mitogen-activated protein kinase FUS3
CMGC KIN28 KIN28_YEAST 6XI8A P06242 6 303 306.0 ADP:401 ATPlike Inactive DFGin 5.5015 15.4441 BLAminus -145.77, -169.62 57.83, 69.55 -84.3, 48.2 280.55, 74.99 -75.72, -28.64 in-out in 8.9518 Saltbr-out 3.667 HRD-out 58.01, 71.8 -89.69, 32.34 out-in-out SNCoio in-out ActLoopNT-in 2.7014 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -116.0, -16.75 APE9-dihe-na -128.02, 157.65 APE8-dihe-in -70.96, 169.95 APE8-rot-out 44.23 APE67-dihe-in -79.03, -7.97 -69.89, -44.72 APE12-dist-in 12.3867 APE11-dist-in 10.7044 APE10-dist-in 6.15 APE9-dist-in 3.4398 None TPO162 TPO162 EM 3.64 999.0 999.0 A 301.0 290.0 8 28 28 0 [[7, 290]] 1.0 6xi8 Saccharomyces cerevisiae CMGC_KIN28_YEAST CMGC 4.1e-70 242.3 1.0 301.0 301.0 146 147 148 150 152 36 54 58 126 128 127 129.0 187 174 169 168 167 166 165 164 163 84 Serine/threonine-protein kinase KIN28
CMGC KIN28 KIN28_YEAST 7KUEA P06242 6 303 306.0 ADP:401 ATPlike Inactive DFGin 5.5017 15.4445 BLAminus -145.81, -169.57 57.84, 69.51 -84.28, 48.19 280.53, 74.97 -75.72, -28.63 in-out in 8.9524 Saltbr-out 3.6675 HRD-out 58.03, 71.82 -89.76, 32.34 out-in-out SNCoio in-out ActLoopNT-in 2.7016 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -115.99, -16.84 APE9-dihe-na -127.96, 157.63 APE8-dihe-in -70.94, 169.94 APE8-rot-out 44.25 APE67-dihe-in -79.07, -7.97 -69.92, -44.62 APE12-dist-in 12.3861 APE11-dist-in 10.7049 APE10-dist-in 6.1497 APE9-dist-in 3.4396 None TPO162 TPO162 EM 3.5 999.0 999.0 A 306.0 290.0 8 28 28 0 [[7, 290]] 1.0 7kue Saccharomyces cerevisiae CMGC_KIN28_YEAST CMGC 4.4e-70 242.3 1.0 301.0 301.0 146 147 148 150 152 36 54 58 126 128 127 129.0 187 174 169 168 167 166 165 164 163 84 Serine/threonine-protein kinase KIN28
CMGC SKY1 SKY1_YEAST 1Q8YA Q03656 144 737 742.0 ADP:60810 ATPlike Active DFGin 5.5538 12.776 BLAminus -120.8, -179.55 50.32, 80.87 -92.72, 24.06 294.38, 19.86 -63.4, -18.16 in-in in 8.712 Saltbr-in 2.7404 HRD-in -75.73, -45.78 71.18, -6.61 in-in-in SNCiii in-in ActLoopNT-in 2.9649 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.41, 175.98 APE9-dihe-na 63.08, 152.12 APE8-dihe-in -90.87, 131.26 APE8-rot-in 290.95 APE67-dihe-in -56.18, -26.85 -9.03, -76.03 APE12-dist-in 12.5336 APE11-dist-in 10.4963 APE10-dist-in 7.5074 APE9-dist-in 2.9897 None None None XRAY 2.05 0.209 0.244 A 373.0 351.0 11 25 25 0 [[158, 706]] 1.0 1q8y Saccharomyces cerevisiae CMGC_SKY1_YEAST CMGC 8.8e-100 339.7 1.0 301.0 301.0 549 550 551 553 555 187 202 206 291 293 292 294.0 586 574 569 568 567 566 565 564 563 247 Serine/threonine-protein kinase SKY1
OTHER BUD32 BUD32_YEAST 4WW9A P53323 4 259 261.0 ADP:302 ATPlike Active DFGin 6.6178 15.2832 BLAminus -128.14, 172.87 62.95, 73.82 -100.2, 23.36 281.69, 91.54 -52.55, -36.42 in-in in 7.602 Saltbr-in 2.7444 HRD-in -80.98, -51.42 97.59, -12.36 in-in-na SNCiia in-na ActLoopNT-in 2.852 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -61.46, -46.34 APE9-dihe-na -60.52, -40.33 APE8-dihe-na -68.91, -38.47 APE8-rot-na 168.71 APE67-dihe-na -62.48, -38.16 -54.4, -51.68 APE12-dist-na 15.7325 APE11-dist-na 11.1786 APE10-dist-na 14.6865 APE9-dist-na 11.7341 None None None XRAY 1.951 0.18 0.209 A 261.0 238.0 20 23 23 0 [[17, 261]] 1.0 4ww9 Saccharomyces cerevisiae OTHER_BUD32_YEAST TP53RK 5e-44 156.6 8.0 224.0 217.0 181 182 183 185 187 52 76 80 158 160 159 161.0 198 204 199 198 197 196 195 194 193 107 EKC/KEOPS complex subunit BUD32
OTHER CDC7 CDC7_YEAST 7PT78 P06243 10 475 507.0 ADP:1001,BEF:1003 ATPlike,Allosteric Inactive DFGin 7.05 14.8279 ABAminus -125.48, -62.19 -62.72, 136.55 -132.76, 24.05 270.26, 81.1 -56.4, -43.64 in-out in 8.9564 Saltbr-out 6.8378 HRD-out -95.15, 91.19 -59.72, -45.2 out-in-out SNCoio in-out ActLoopNT-in 2.4184 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiii APE10-dihe-na -63.65, 141.8 APE9-dihe-na 169.57, -141.23 APE8-dihe-in -138.07, 164.32 APE8-rot-in 301.9 APE67-dihe-out 82.72, -175.36 -64.25, 106.81 APE12-dist-in 8.8541 APE11-dist-in 11.0152 APE10-dist-in 5.0432 APE9-dist-in 4.6257 None None None EM 3.8 999.0 999.0 8 507.0 402.0 64 107 61 46 [[33, 469]] 1.0 7pt7 Saccharomyces cerevisiae OTHER_CDC7_YEAST CMGC 4e-17 121.0 1.0 158.0 260.0 181 182 183 185 187 76 90 94 160 162 161 163.0 301 288 283 282 281 280 279 278 277 121 Cell division control protein 7
OTHER IRE1 IRE1_YEAST 2RIOA P32361 665 1115 1115.0 ADP:61101 ATPlike None DFGin 5.0319 14.6663 BLAminus -125.01, -166.82 59.91, 72.41 -79.74, 13.1 278.94, 57.84 -50.86, -29.29 out-in out 10.3602 Saltbr-in 3.5441 HRD-in -69.38, -55.95 80.27, 5.91 in-in-none SNCiin in-none ActLoopNT-in 2.6844 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 148.77 APE8-rot-in 240.38 APE67-dihe-in -59.81, -10.2 -102.36, 14.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.224 0.266 A 434.0 396.0 26 32 18 14 [[672, 977]] 1.0 2rio Saccharomyces cerevisiae OTHER_IRE1_YEAST TKL 1e-35 129.7 4.0 263.0 260.0 827 828 829 831 833 702 715 719 794 796 795 797.0 902 859 854 853 852 851 850 849 848 746 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER IRE1 IRE1_YEAST 2RIOB P32361 665 1115 1115.0 ADP:62101 ATPlike Inactive DFGin 5.1319 14.4012 BLAminus -133.23, -169.67 57.3, 77.4 -91.55, 18.06 279.67, 55.41 -50.86, -27.7 in-in in 9.9668 Saltbr-in 3.5542 HRD-in -79.44, -44.63 66.11, 11.75 in-in-out SNCiio in-out ActLoopNT-in 2.7644 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 139.02 APE8-rot-out 206.66 APE67-dihe-in -67.78, -12.45 -143.81, 21.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.224 0.266 B 434.0 395.0 27 32 18 14 [[672, 977]] 1.0 2rio Saccharomyces cerevisiae OTHER_IRE1_YEAST TKL 1e-35 129.7 4.0 263.0 260.0 827 828 829 831 833 702 715 719 794 796 795 797.0 902 859 854 853 852 851 850 849 848 746 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER IRE1 IRE1_YEAST 3LJ0A P32361 665 1115 1115.0 ADP:2101,QUE:1 ATPlike,Allosteric None DFGin 5.6568 14.5198 BLAminus -127.75, -159.8 55.73, 76.2 -100.97, 26.65 278.19, 55.54 -68.42, -38.12 in-in in 9.3145 Saltbr-in 3.0432 HRD-in -75.54, -40.03 69.65, -11.03 in-in-none SNCiin in-none ActLoopNT-in 2.8835 ActLoopCT-none nonTYR APEdihe_aanni APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -61.99 APE8-rot-none 999.0 APE67-dihe-in -81.59, -8.09 -104.48, 18.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP840,SEP841,TPO844 SEP840,SEP841,TPO844 XRAY 3.2 0.217 0.224 A 434.0 407.0 20 32 25 7 [[672, 977]] 1.0 3lj0 Saccharomyces cerevisiae OTHER_IRE1_YEAST TKL 1e-35 129.7 4.0 263.0 260.0 827 828 829 831 833 702 715 719 794 796 795 797.0 902 859 854 853 852 851 850 849 848 746 Serine/threonine-protein kinase/endoribonuclease IRE1
OTHER IRE1 IRE1_YEAST 3LJ0B P32361 670 1115 1115.0 ADP:2101,QUE:1 ATPlike,Allosteric None DFGin 5.6395 14.5291 BLAminus -127.76, -160.17 56.44, 75.29 -99.49, 26.48 278.86, 54.86 -67.91, -37.63 in-in in 9.3315 Saltbr-in 3.0881 HRD-in -76.48, -40.82 70.18, -10.34 in-in-none SNCiin in-none ActLoopNT-in 2.8642 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -62.45 APE8-rot-in 292.53 APE67-dihe-in -81.7, -8.3 -104.03, 18.85 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP840,SEP841,TPO844 SEP840,SEP841,TPO844 XRAY 3.2 0.217 0.224 B 434.0 402.0 20 32 25 7 [[672, 977]] 1.0 3lj0 Saccharomyces cerevisiae OTHER_IRE1_YEAST TKL 1e-35 129.7 4.0 263.0 260.0 827 828 829 831 833 702 715 719 794 796 795 797.0 902 859 854 853 852 851 850 849 848 746 Serine/threonine-protein kinase/endoribonuclease IRE1
TYR VKR2 A0A3Q0KQ92_SCHMA 7ZVSA A0A3Q0KQ92 943 1257 1641.0 ADP:1301 ATPlike Inactive DFGin 6.4107 13.9115 ABAminus -108.2, -51.57 -108.14, 130.38 -125.76, 34.81 311.68, 99.72 -69.75, -23.67 in-out in 7.915 Saltbr-out 4.4345 HRD-in -84.85, -39.64 60.03, 4.72 out-in-none SNCoin in-none ActLoopNT-in 3.1146 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 132.51 APE8-dihe-in -86.18, 75.72 APE8-rot-na 32.5 APE67-dihe-in -65.42, -24.56 -66.74, -36.8 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.6537 None None None XRAY 3.07 0.219 0.252 A 341.0 300.0 15 33 18 15 [[966, 1240]] 1.0 7zvs Schistosoma mansoni TYR_VKR2_SCHMA TYR 2.6e-69 239.5 1.0 253.0 253.0 1117 1118 1119 1121 1123 997 1014 1018 1097 1099 1098 1100.0 1162 1150 1145 1144 1143 1142 1141 1140 1139 1045 Guanylate cyclase
TYR VKR2 A0A3Q0KQ92_SCHMA 7ZVSB A0A3Q0KQ92 946 1257 1641.0 ADP:1301 ATPlike Inactive DFGin 6.6225 14.5211 ABAminus -98.3, -71.59 -103.46, 126.3 -111.19, 44.98 301.93, 110.43 -72.41, -47.73 in-in in 8.9886 Saltbr-in 3.5916 HRD-in -85.3, -43.46 65.5, -4.13 in-in-none SNCiin in-none ActLoopNT-in 3.1678 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 149.82 APE9-dihe-in -99.67, 136.73 APE8-dihe-in -75.43, 94.78 APE8-rot-na 28.24 APE67-dihe-in -74.95, -28.65 -71.49, -32.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 10.7742 APE9-dist-in 6.6 None None None XRAY 3.07 0.219 0.252 B 341.0 296.0 16 33 17 16 [[966, 1240]] 1.0 7zvs Schistosoma mansoni TYR_VKR2_SCHMA TYR 2.6e-69 239.5 1.0 253.0 253.0 1117 1118 1119 1121 1123 997 1014 1018 1097 1099 1098 1100.0 1162 1150 1145 1144 1143 1142 1141 1140 1139 1045 Guanylate cyclase
OTHER YOPO Q93KQ6_YEREN 5CE3B Q93KQ6 108 729 729.0 ADP:60801 ATPlike Inactive None 999.0 999.0 None -135.72, -178.29 65.55, 68.88 -88.43, 18.62 274.24, 50.39 -58.33, -41.28 none-na none 999.0 Saltbr-na 999.0 HRD-in -75.96, -46.65 74.34, -12.04 na-in-out SNCaio in-out ActLoopNT-in 2.9309 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ooii APE10-dihe-na -168.45, -171.64 APE9-dihe-na -171.12, 163.26 APE8-dihe-in -100.11, 126.72 APE8-rot-in 306.6 APE67-dihe-in -62.68, -33.12 -66.23, -36.58 APE12-dist-out 6.8938 APE11-dist-out 3.8172 APE10-dist-in 5.1847 APE9-dist-in 3.949 K205Y,E206Y,E207Y,K440Y,K441Y None None XRAY 2.93 0.198 0.24 B 643.0 598.0 0 23 23 0 [[144, 405]] 1.0 5ce3 Yersinia enterocolitica OTHER_YOPO_YEREN STE 4.1e-06 32.8 55.0 256.0 202.0 285 286 287 289 291 0 0 0 264 266 265 267.0 321 308 303 302 301 300 299 298 297 212 YopO
OTHER YOPO Q93KQ6_YEREN 5CE3D Q93KQ6 108 729 729.0 ADP:60801 ATPlike Inactive None 999.0 999.0 None -137.87, -178.9 65.7, 69.62 -87.46, 18.2 287.37, 172.47 -59.1, -40.66 none-na none 999.0 Saltbr-na 999.0 HRD-in -75.41, -46.8 73.5, -11.21 na-in-out SNCaio in-out ActLoopNT-in 2.9231 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ooii APE10-dihe-na -169.34, -172.42 APE9-dihe-na -171.36, 163.27 APE8-dihe-in -100.95, 126.72 APE8-rot-in 306.77 APE67-dihe-in -63.23, -33.24 -66.66, -36.24 APE12-dist-out 6.8767 APE11-dist-out 3.8149 APE10-dist-in 5.1725 APE9-dist-in 3.9376 K205Y,E206Y,E207Y,K440Y,K441Y None None XRAY 2.93 0.198 0.24 D 643.0 598.0 0 23 23 0 [[144, 405]] 1.0 5ce3 Yersinia enterocolitica OTHER_YOPO_YEREN STE 4.1e-06 32.8 55.0 256.0 202.0 285 286 287 289 291 0 0 0 264 266 265 267.0 321 308 303 302 301 300 299 298 297 212 YopO