CMGC_CDK11B (Cyclin-dependent kinase 11B)

Total number of chains: 9
Active chains: 2
Uniprot: CD11B_HUMAN
Kinase Domain Residues: 438 - 723
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 6 66.7% 7UKZB
DFGin BLAminus 3 33.3% AF-P21127-K1A

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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-P21127-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 430 - 731 0 None None Cyclin-dependent kinase 11B
AF-P21127-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 430 - 731 0 None None Cyclin-dependent kinase 11B
7UKZA 2.6 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NK3 Type1 436 - 736 0 TPO595 None Cyclin-dependent kinase 11B
7UKZB 2.6 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NK3 Type1 436 - 736 0 TPO595 None Cyclin-dependent kinase 11B
7UKZC 2.6 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii NK3 Type1 436 - 736 0 TPO595 None Cyclin-dependent kinase 11B
7UKZD 2.6 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NK3 Type1 437 - 736 0 TPO595 None Cyclin-dependent kinase 11B
7UKZE 2.6 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NK3 Type1 435 - 736 0 TPO595 None Cyclin-dependent kinase 11B
7UKZF 2.6 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii NK3 Type1 436 - 736 0 TPO595 None Cyclin-dependent kinase 11B
9I9IK 3.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 440 - 740 0 TPO595 None Cyclin-dependent kinase 11B

CMGC_CDK11B (Cyclin-dependent kinase 11B)

Total number of chains: 9
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 6 66.7% 7UKZB
DFGin BLAminus 3 33.3% AF-P21127-K1A

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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CD11B_HUMAN AF-P21127-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 430 - 731 0 None None Cyclin-dependent kinase 11B Homo sapiens
CD11B_HUMAN AF-P21127-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 430 - 731 0 None None Cyclin-dependent kinase 11B Homo sapiens
CD11B_HUMAN 7UKZA 2.6 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NK3 Type1 436 - 736 0 TPO595 None Cyclin-dependent kinase 11B Homo sapiens
CD11B_HUMAN 7UKZB 2.6 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NK3 Type1 436 - 736 0 TPO595 None Cyclin-dependent kinase 11B Homo sapiens
CD11B_HUMAN 7UKZC 2.6 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii NK3 Type1 436 - 736 0 TPO595 None Cyclin-dependent kinase 11B Homo sapiens
CD11B_HUMAN 7UKZD 2.6 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NK3 Type1 437 - 736 0 TPO595 None Cyclin-dependent kinase 11B Homo sapiens
CD11B_HUMAN 7UKZE 2.6 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii NK3 Type1 435 - 736 0 TPO595 None Cyclin-dependent kinase 11B Homo sapiens
CD11B_HUMAN 7UKZF 2.6 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii NK3 Type1 436 - 736 0 TPO595 None Cyclin-dependent kinase 11B Homo sapiens
CD11B_HUMAN 9I9IK 3.5 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii ADP ATPlike 440 - 740 0 TPO595 None Cyclin-dependent kinase 11B Homo sapiens

CMGC_CDK11B (Cyclin-dependent kinase 11B)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative

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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism