Ligand: F

Total number of chains: 168
Active chains: 39
Total number of genes: 62
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 78 46.4% 4AW0A
DFGin ABAminus 20 11.9% 4C57A
DFGin BLAplus 19 11.3% 9UHIA
DFGin None 16 9.5% 8B9EA
DFGin BLBplus 10 6.0% 3ZCLA
DFGout None 9 5.4% 3VO3A
DFGout BBAminus 8 4.8% 4MXCA
DFGin BLBminus 3 1.8% 5XYYA
DFGin BLBtrans 2 1.2% 2R3IA
None None 2 1.2% 5IEXA
DFGinter None 1 0.6% 4EBWA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AGC AKT1 AKT1_HUMAN 4EKLA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 0RF Type1 144 - 478 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase
AGC GRK5 GRK5_HUMAN 9BRPA 2.8 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1ARF Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BREA 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii W3F Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 8UAQA 2.8 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii W3F Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5
AGC PDPK1 PDPK1_HUMAN 4AW0A 1.43 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, MJF ATPlike, Allosteric 75 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1
AGC PRKCH KPCL_HUMAN 8FP1A 1.85 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii XXF Type1 349 - 676 0 TPO513,TPO656 S675E Protein kinase C eta type
CAMK AURKA AURKA_HUMAN 8C1DA 2.115 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno T2F, ADP, T5L Allosteric, ATPlike, Allosteric 127 - 388 0 None C290A Aurora kinase A
CAMK AURKA AURKA_HUMAN 2W1FA 2.85 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_nnno L0F Type1 127 - 389 0 None None Aurora kinase A
CAMK AURKA AURKA_HUMAN 3O51A 3.2 Inactive DFGout‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn LJF Type1.5_Front 126 - 388 0 None None Aurora kinase A
CAMK CAMK2A KCC2A_HUMAN 2VZ6A 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii FEF Type1 9 - 299 0 None None Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 2VZ6B 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii FEF Type1 9 - 300 0 None None Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CHEK1 CHK1_HUMAN 8E80A 1.49 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii UUF Type1 8 - 271 0 None N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S Serine/threonine-protein kinase Chk1
CAMK CHEK2 CHK2_HUMAN 2YCFA 1.77 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_oooo YCF Type1 210 - 510 0 None None Serine/threonine-protein kinase Chk2
CAMK DAPK1 DAPK1_HUMAN 6AARA 1.95 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9TF Type1 2 - 277 0 None None Death-associated protein kinase 1
CAMK MAPKAPK2 MAPK2_HUMAN 3M42A 2.68 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn HGF Type1 47 - 364 0 None P237G MAP kinase-activated protein kinase 2
CAMK MELK MELK_HUMAN 5IH9A 1.79 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_nnnn 6BF Type1 3 - 327 0 None None Maternal embryonic leucine zipper kinase
CAMK PIM1 PIM1_HUMAN 5KGIA 2.13 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6SF Type1 33 - 305 0 None None Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 6L13A 2.24 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii E2F Type1 33 - 305 0 SEP261 None Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 2O65A 2.85 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii MYF Type1 33 - 306 0 None None Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 8R0WA 1.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii XGF Type1 33 - 305 0 SEP261 R250G Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 8AFRA 2.15 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii M0F Type1 33 - 305 0 SEP261 R250G Serine/threonine-protein kinase pim-1
CMGC CDK12 CDK12_HUMAN 8BU5B 3.134 Inactive DFGin‑ABAminus in-out in-out nonTYR APEdihe_aaiii APEdist_oiii RMF Type1 713 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU5H 3.134 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RMF Type1 713 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUNB 3.08 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RNF Type1 715 - 1041 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUNH 3.08 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RNF Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 9FMRE 3.9 Inactive DFGin‑ABAminus in-out in-out nonTYR APEdihe_aaiii APEdist_oiii RMF Type1 714 - 1042 0 TPO893 None Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 9FMRH 3.9 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RMF Type1 714 - 1044 0 TPO893 None Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUNE 3.08 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RNF Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8P81A 2.68 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RMF Type1 716 - 1035 0 TPO893 None Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU5E 3.134 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaiii APEdist_oiii RMF Type1 713 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 9FMRB 3.9 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii RMF Type1 714 - 1047 0 TPO893 None Cyclin-dependent kinase 12
CMGC CDK16 CDK16_HUMAN 3MTLA 2.4 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn FEF Type1 163 - 473 0 None S319D Cyclin-dependent kinase 16
CMGC CDK2 CDK2_HUMAN 9ESWA 2.38 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii IJF, IJF, IJF, IJF Allosteric, Type1, Allosteric, Allosteric 1 - 294 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9ESWC 2.38 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii IJF, IJF, IJF, IJF Allosteric, Type1, Allosteric, Allosteric 1 - 296 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9OB4A 1.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1CAF Type1 1 - 298 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4BCQA 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii TJF Type1 1 - 295 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4BCQC 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii TJF Type1 1 - 294 0 TPO160 None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 7S9XA 1.69 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo 8KF Type3 3 - 298 0 None None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2W1HA 2.15 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_nnno L0F Type1 1 - 298 0 None None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2R3IA 1.28 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_oooo SCF Type1 1 - 298 0 None None Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 5IEXA 2.03 Inactive None‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnno 6AF Type1 1 - 298 0 None None Cyclin-dependent kinase 2
CMGC CDK6 CDK6_HUMAN 9PE7A 2.05 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaiii APEdist_nnoo A1CIF Type1 10 - 301 0 None E21V,K26T,T106R,Q149E Cyclin-dependent kinase 6
CMGC CDK7 CDK7_HUMAN 8P71J 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii X4F Type1 10 - 310 0 None None Cyclin-dependent kinase 7
CMGC CDK8 CDK8_HUMAN 9H8SA 2.157 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn A1ITF Type1 1 - 362 0 None None Cyclin-dependent kinase 8
CMGC CSNK2A1 CSK21_HUMAN 8AEMA 1.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii LVF, ATP Allosteric, ATPlike 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 9EPWB 2.3 Active DFGin‑BLAminus out-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1H6F Type1 3 - 333 0 None None Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 2ZJWA 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii REF Type1 1 - 332 0 None None Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7I8AA 1.84 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1B0F Type1 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha
CMGC DYRK1A DYR1A_HUMAN 6A1FA 1.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 9OF Type1 134 - 483 0 PTR321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK2 DYRK2_HUMAN 7DH9A 2.194 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii H7F Type1 215 - 538 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2
CMGC GSK3B GSK3B_HUMAN 9PE9A 2.11 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii A1CIF Type1 36 - 382 0 PTR216 None Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 9PE9B 2.11 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii A1CIF Type1 36 - 382 0 PTR216 None Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 4PTEA 2.033 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 2WF Type1 36 - 382 0 None None Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 4PTEB 2.033 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 2WF Type1 36 - 385 0 None None Glycogen synthase kinase-3 beta
CMGC MAPK1 MK01_HUMAN 5BVDA 1.9 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_nnnn 4VF Type1 9 - 358 0 None None Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8AO6A 1.811 Inactive DFGin‑BLAminus out-in in-out nonTYR APEdihe_aaiii APEdist_oiii N9F Type1 11 - 356 0 None None Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8AO9A 1.624 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_oiii N4F Type1 11 - 356 0 None None Mitogen-activated protein kinase 1
CMGC MAPK10 MK10_HUMAN 3CGFA 3.0 Inactive DFGin‑ABAminus in-out none-out nonTYR APEdihe_aaiii APEdist_oooo JNF Type1 45 - 400 0 None None Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 7YL1A 2.48 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaiii APEdist_oooo J6F Type1 45 - 400 0 None None Mitogen-activated protein kinase 10
CMGC MAPK14 MK14_HUMAN 6ZQSA 1.95 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii 3FF Type1 4 - 353 0 TPO180,PTR182 None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 5XYYA 1.7 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo P0F Type1.5_Back 4 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 2QD9A 1.7 Inactive DFGin‑BLBplus in-in none-none nonTYR APEdihe_aannn APEdist_nnnn LGF Type1 5 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3QUDA 2.0 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaoii APEdist_nnoo N3F Type1 4 - 354 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3QUEA 2.7 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaoii APEdist_nnoo 3FF Type1 5 - 353 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4R3CA 2.06 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaoii APEdist_nnno 3GF, 3GF Type1, Allosteric 4 - 352 0 None None Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3L8SA 2.35 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno BFF Type1 4 - 353 0 None C119S,C162S,A172C,F327L Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3UVRA 2.1 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno 06F Type2 5 - 351 0 None None Mitogen-activated protein kinase 14
CMGC MAPK8 MK08_HUMAN 8PTAA 2.41 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaioi APEdist_iooo CIF Type1 8 - 363 0 None None Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 8PTAB 2.41 Inactive DFGin‑ABAminus in-in none-out nonTYR APEdihe_aaioi APEdist_iioo CIF Type1 7 - 363 0 None None Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 8PTAC 2.41 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaioi APEdist_nnoo CIF Type1 8 - 361 0 None None Mitogen-activated protein kinase 8
CMGC MAPK9 MK09_HUMAN 3E7OA 2.14 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaiio APEdist_oooo 35F Type1 9 - 361 0 None C177S,C222S,K250A,K251A,K265A,K270A Mitogen-activated protein kinase 9
CMGC MAPK9 MK09_HUMAN 3E7OB 2.14 Inactive DFGin‑ABAminus in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn 35F Type1 8 - 362 0 None C177S,C222S,K250A,K251A,K265A,K270A Mitogen-activated protein kinase 9
OTHER CDC7 CDC7_HUMAN 6YA8A 1.79 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnni ADP, BEF ATPlike, Allosteric 38 - 572 0 None None Cell division cycle 7-related protein kinase
OTHER GAK GAK_HUMAN 4C57A 2.55 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii FEF Type1 25 - 334 0 None None Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 4C57B 2.55 Inactive DFGin‑ABAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii FEF Type1 27 - 334 0 None None Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 4C59A 2.8 Inactive DFGin‑ABAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn FEF Type1 27 - 333 0 None None Cyclin-G-associated kinase
OTHER HASPIN HASP_HUMAN 9FLTA 2.4 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa A1IDF Type1 471 - 798 0 None None Serine/threonine-protein kinase haspin
OTHER TTK TTK_HUMAN 4JS8A 1.94 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaini APEdist_nnoo 1PF Type1 515 - 793 0 TPO675,TPO686 None Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 7CHMA 2.65 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaoni APEdist_nnoo FZF Type1 516 - 794 0 TPO675,TPO686 None Dual specificity protein kinase TTK
OTHER ULK1 ULK1_HUMAN 4WNOA 1.56 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 3RF Type1 8 - 280 0 TPO180 E37A,K38A Serine/threonine-protein kinase ULK1
STE MAP2K1 MP2K1_HUMAN 7UMBC 3.231 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, U9F ATPlike, Type3 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K7 MP2K7_HUMAN 6YG3A 2.05 None DFGin‑BLAminus in-na in-none nonTYR APEdihe_aannn APEdist_nnnn 6HF Type1 103 - 400 0 None None Dual specificity mitogen-activated protein kinase kinase 7
STE MAP4K1 M4K1_HUMAN 8FH4A 1.827 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo XXF Type1 4 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FH4B 1.827 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo XXF Type1 6 - 302 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FH4C 1.827 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo XXF Type1 1 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FH4D 1.827 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno XXF Type1 8 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9QT6A 1.76 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioo A1JAF Type1 6 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8CIJA 2.821 Inactive DFGout‑None out-out none-none nonTYR APEdihe_aaiii APEdist_nnni USF Type1 14 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K4 M4K4_HUMAN 5DI1A 2.9 Inactive DFGin‑BLBplus in-out none-out nonTYR APEdihe_aaioi APEdist_nnno 5DF Type1 13 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4
TKL ACVR1 ACVR1_HUMAN 3MTFA 2.15 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi A3F Type1 203 - 498 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 3MTFB 2.15 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi A3F Type1 202 - 499 0 None Q207D Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 6EIXA 2.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi A3F Type1 192 - 503 0 None Q207E Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 8PODA 2.59 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi 7IO, F Type1, Allosteric 172 - 498 0 None None Activin receptor type-1
TKL BRAF BRAF_HUMAN 4YHTA 3.05 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnno 4EF Type1 449 - 719 0 None I543T,I544N,I551T,L706T,L716T Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 4YHTB 3.05 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnno 4EF Type1 449 - 720 0 None I543T,I544N,I551T,L706T,L716T Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 3Q96A 3.1 Inactive DFGout‑BBAminus in-in none-none nonTYR APEdihe_aanii APEdist_nnnn 0NF Type2 449 - 722 0 None None Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 3Q96B 3.1 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaiii APEdist_nnno 0NF Type2 449 - 720 0 None None Serine/threonine-protein kinase B-raf
TKL IRAK4 IRAK4_HUMAN 4YP8A 2.641 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4GF Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4YP8B 2.641 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4GF Type1 161 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4YP8C 2.641 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4GF Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4YP8D 2.641 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4GF Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6LXYA 2.19 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii EXF Type1 163 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6LXYB 2.19 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii EXF Type1 163 - 459 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6LXYD 2.19 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii EXF Type1 162 - 459 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6LXYE 2.19 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii EXF Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4
TKL MAP3K12 M3K12_HUMAN 5CEQA 1.911 Inactive DFGin‑BLBplus out-na none-out nonTYR APEdihe_aaooi APEdist_nnno 50F Type1 117 - 398 0 None None Mitogen-activated protein kinase kinase kinase 12
TKL MAP3K7 M3K7_HUMAN 5J9LA 2.752 Inactive DFGout‑None in-out none-out nonTYR APEdihe_aaoii APEdist_nnno 6HF Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7
TKL RIPK1 RIPK1_HUMAN 7FCZA 2.21 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaiii APEdist_nnno 3IF Type3 10 - 294 0 None C34A,C127A,C233A,C240A Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 7FCZB 2.21 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnno 3IF Type3 7 - 294 0 None C34A,C127A,C233A,C240A Receptor-interacting serine/threonine-protein kinase 1
TKL TGFBR1 TGFR1_HUMAN 2WOUA 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ZZF Type1 200 - 496 0 None None TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 3FAAA 3.35 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 55F Type1 171 - 500 0 None None TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 3FAAB 3.35 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 55F Type1 171 - 501 0 None None TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 3FAAC 3.35 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_iiii 55F Type1 171 - 500 0 None None TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 3FAAD 3.35 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 55F Type1 171 - 500 0 None None TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 3FAAE 3.35 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 55F Type1 171 - 500 0 None None TGF-beta receptor type-1
TKL TGFBR2 TGFR2_HUMAN 7DV6A 2.39 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii HJF Type1 240 - 543 0 None E431A,R433A,E485A,K488A,R493A,R495A TGF-beta receptor type-2
TYR ALK ALK_HUMAN 4CCUA 2.0 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaai AWF Type1 1093 - 1402 0 None None ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 4FNZA 2.6 Inactive DFGin‑ABAminus in-in none-out TYR APEdihe_oiiai APEdist_aaai NZF Type1 1093 - 1402 0 None C1097S ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 4DCEA 2.03 Inactive DFGin‑None in-in none-out TYR APEdihe_oiiai APEdist_aaai 0JF Type1 1093 - 1402 0 None C1097S ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 4DCEB 2.03 Inactive DFGin‑None in-in none-out TYR APEdihe_oiiai APEdist_aaao 0JF Type1 1094 - 1402 0 None C1097S ALK tyrosine kinase receptor
TYR BTK BTK_HUMAN 5FBNC 1.8 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 5WF, 5WE Type1.5_Front, Allosteric 395 - 658 0 None None Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 5FBND 1.8 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai 5WF, 5WE, 5WE, 5WE Type1.5_Front, Allosteric, Allosteric, Allosteric 394 - 658 0 None None Tyrosine-protein kinase BTK
TYR DDR1 DDR1_HUMAN 5SAUA 1.8 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 1IF Type2 604 - 912 0 None None Epithelial discoidin domain-containing receptor 1
TYR EPHA2 EPHA2_HUMAN 8BOCA 1.9 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai QUF Type2 605 - 888 0 None None Ephrin type-A receptor 2
TYR EPHB4 EPHB4_HUMAN 2X9FA 1.75 Inactive DFGin‑BLBminus in-in out-in TYR APEdihe_iiiai APEdist_aaai X9F Type1 608 - 888 0 None Y774E Ephrin type-B receptor 4
TYR FGFR1 FGFR1_HUMAN 9UHIA 1.76 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_iioai APEdist_aaao A1EPF Type1 458 - 764 0 None None Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 9UHIB 1.76 Inactive DFGin‑BLAplus in-in none-out TYR APEdihe_iioai APEdist_aaao A1EPF Type1 458 - 763 0 None None Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 3C4FA 2.07 Inactive DFGin‑BLAplus in-out out-out TYR APEdihe_iioai APEdist_aaao C4F Type1.5_Back 464 - 765 0 None C488A Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 3C4FB 2.07 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_iioai APEdist_aaao C4F Type1.5_Back 464 - 765 0 None C488A Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 5EW8A 1.63 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_iioai APEdist_aaao 5SF Type1.5_Back 464 - 765 0 None None Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 5EW8B 1.63 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_iioai APEdist_aaao 5SF Type1.5_Back 461 - 765 0 None None Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 7WCLA 2.495 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_iioai APEdist_aaao 8ZF Type1.5_Back 459 - 764 0 None C584S Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 7WCLB 2.495 Inactive DFGin‑BLAplus in-in none-out TYR APEdihe_iioai APEdist_aaao 8ZF Type1.5_Back 458 - 763 0 None C584S Fibroblast growth factor receptor 1
TYR FGFR3 FGFR3_HUMAN 8UDTA 2.829 Inactive DFGin‑BLAplus in-out out-out TYR APEdihe_nnoai APEdist_aaao MLT, MLT, WGF Allosteric, Allosteric, Type1.5_Front 457 - 756 0 None P572S,P573G Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 8UDTB 2.829 Inactive DFGin‑BLAplus in-out out-out TYR APEdihe_nooai APEdist_aaao WGF Type1.5_Front 457 - 754 0 None P572S,P573G Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 8UDTC 2.829 Inactive DFGin‑BLAplus in-out out-out TYR APEdihe_nooai APEdist_aaao WGF Type1.5_Front 457 - 756 0 None P572S,P573G Fibroblast growth factor receptor 3
TYR FGFR4 FGFR4_HUMAN 7WCXA 2.175 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_iioai APEdist_aaao 90F Type1 453 - 752 0 None C477A,R664E Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 7WCWA 2.317 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_iioai APEdist_aaao 90F Type1 453 - 752 0 None C477A,R664E Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 6JPJA 2.638 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_iioai APEdist_aaao FGF Type1 454 - 752 0 None C477A,R664E Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 7VJLA 2.9 Inactive DFGin‑BLAplus in-in none-none TYR APEdihe_nnnai APEdist_aaan 7IF Type1 454 - 753 0 None None Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 7VJLB 2.9 Inactive DFGin‑BLAplus in-in none-none TYR APEdihe_nnnai APEdist_aaan 7IF Type1 453 - 753 0 None None Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 6YI8A 2.13 Inactive DFGin‑BLAplus in-in none-out TYR APEdihe_niiai APEdist_aaao FGF Type1 453 - 753 0 None None Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 6YI8B 2.13 Inactive DFGin‑BLAplus in-in none-out TYR APEdihe_nniai APEdist_aaao FGF Type1 451 - 752 0 None None Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 7WCTA 2.106 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_iioai APEdist_aaao 90F Type1 453 - 752 0 None R664E Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 5XFJA 3.25 Inactive DFGin‑None in-out none-out TYR APEdihe_nniai APEdist_aaao 6LF Type1 453 - 750 0 None V550M Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 5XFFA 2.7 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao 6LF Type1 453 - 750 0 None V550L Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 5JKGA 2.352 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao 6LF Type1 453 - 750 0 None None Fibroblast growth factor receptor 4
TYR FLT3 FLT3_HUMAN 6JQRA 2.2 Inactive DFGout‑None in-in none-in TYR APEdihe_iiiai APEdist_aaai C6F Type1 571 - 951 0 None None Receptor-type tyrosine-protein kinase FLT3
TYR HCK HCK_HUMAN 3VS4A 2.747 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao VSF Type1.5_Back 81 - 526 0 PTR522 Q523E,Q524E,Q525I Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 3VS4B 2.747 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao VSF Type1.5_Back 81 - 526 0 PTR522 Q523E,Q524E,Q525I Tyrosine-protein kinase HCK
TYR JAK2-1 JAK2_HUMAN 8B9EA 1.5 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao Q7F Type1 536 - 809 0 None W777A,F794H Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B9HA 1.5 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao Q7F Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2
TYR KDR VGFR2_HUMAN 3VO3A 1.52 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai 0KF Type2 812 - 1168 0 None None Vascular endothelial growth factor receptor 2
TYR KDR VGFR2_HUMAN 1YWNA 1.71 Inactive None‑None in-in none-out TYR APEdihe_iioai APEdist_aaao LIF Type1 820 - 1171 0 PTR1054,PTR1059 E990V Vascular endothelial growth factor receptor 2
TYR LCK LCK_HUMAN 2ZM1A 2.1 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KSF Type1 231 - 501 0 PTR394 None Tyrosine-protein kinase Lck
TYR MERTK MERTK_HUMAN 9BHIA 2.07 Inactive DFGin‑BLAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai A1APF Type1.5_Front 578 - 864 0 None None Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AB1A 1.93 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan C6F Type1 571 - 862 0 None K591R,K693R,K702R,K856R Tyrosine-protein kinase Mer
TYR MET MET_HUMAN 3ZCLA 1.4 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 5TF Type1 1052 - 1345 0 None None Hepatocyte growth factor receptor
TYR MET MET_HUMAN 4MXCA 1.632 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai DWF Type2 1052 - 1346 0 None None Hepatocyte growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5H3QA 2.1 Inactive DFGout‑BBAminus in-out out-in TYR APEdihe_iiiai APEdist_aaai 7HF Type1 484 - 796 0 None None High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5KMJA 2.04 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai 6UF Type3 486 - 795 0 None None High affinity nerve growth factor receptor
TYR PTK2 FAK1_HUMAN 4EBWA 2.65 Inactive DFGinter‑None in-in none-out TYR APEdihe_niiai APEdist_aaao 0PF Type1 411 - 686 0 None None Focal adhesion kinase 1
TYR SYK KSYK_HUMAN 5LMBA 1.95 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 6ZF Type1 364 - 634 0 PTR525 None Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 5LMBB 1.95 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai 6ZF Type1 364 - 630 0 PTR525 None Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4YJOA 1.6 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 4DF Type1 363 - 632 0 None None Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 5TT7A 1.77 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 7KF Type1 358 - 635 0 None None Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4FYOA 1.4 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 0VF Type1 363 - 635 0 None None Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4GFGA 2.35 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0XF Type1 363 - 635 0 None None Tyrosine-protein kinase SYK

Ligand: F

Total number of chains: 181
Active chains: 40
Total number of genes: 65
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 86 47.5% 4AW0A
DFGin ABAminus 22 12.2% 7PIEA
DFGin BLAplus 19 10.5% 9UHIA
DFGin None 16 8.8% 8B9EA
DFGin BLBplus 10 5.5% 3ZCLA
DFGout BBAminus 10 5.5% 4MXCA
DFGout None 9 5.0% 3VO3A
DFGin BLBminus 4 2.2% 5R9OA
DFGin BLBtrans 2 1.1% 2R3IA
None None 2 1.1% 5IEXA
DFGinter None 1 0.6% 4EBWA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
AGC PRKACA KAPCA_CRIGR 7PIEA 1.427 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 7QF Type1 1 - 351 0 SEP11,SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKACA KAPCA_CRIGR 9RETA 1.75 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1JEF Allosteric 13 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
TYR SRC SRC_CHICK 5SYSA 2.8 Inactive DFGout‑BBAminus in-in none-none TYR APEdihe_nnnai APEdist_aaan 72F Type2 258 - 533 0 None V281C Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 5SYSB 2.8 Inactive DFGout‑BBAminus in-in none-none TYR APEdihe_nnnai APEdist_aaan 72F Type2 258 - 533 0 None V281C Proto-oncogene tyrosine-protein kinase Src Gallus gallus
AGC AKT1 AKT1_HUMAN 4EKLA 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 0RF Type1 144 - 478 0 TPO308 S473D RAC-alpha serine/threonine-protein kinase Homo sapiens
AGC GRK5 GRK5_HUMAN 9BRPA 2.8 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1ARF Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5 Homo sapiens
AGC GRK5 GRK5_HUMAN 9BREA 2.8 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii W3F Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5 Homo sapiens
AGC GRK5 GRK5_HUMAN 8UAQA 2.8 Inactive DFGin‑None in-in in-in nonTYR APEdihe_aaiii APEdist_iiii W3F Type1 25 - 542 0 None D311N G protein-coupled receptor kinase 5 Homo sapiens
AGC PDPK1 PDPK1_HUMAN 4AW0A 1.43 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ATP, MJF ATPlike, Allosteric 75 - 359 0 SEP241 Y288G,Q292A 3-phosphoinositide-dependent protein kinase 1 Homo sapiens
AGC PRKCH KPCL_HUMAN 8FP1A 1.85 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii XXF Type1 349 - 676 0 TPO513,TPO656 S675E Protein kinase C eta type Homo sapiens
CAMK AURKA AURKA_HUMAN 8C1DA 2.115 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_nnno T2F, ADP, T5L Allosteric, ATPlike, Allosteric 127 - 388 0 None C290A Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 2W1FA 2.85 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaioi APEdist_nnno L0F Type1 127 - 389 0 None None Aurora kinase A Homo sapiens
CAMK AURKA AURKA_HUMAN 3O51A 3.2 Inactive DFGout‑None out-none none-none nonTYR APEdihe_aannn APEdist_nnnn LJF Type1.5_Front 126 - 388 0 None None Aurora kinase A Homo sapiens
CAMK CAMK2A KCC2A_HUMAN 2VZ6A 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii FEF Type1 9 - 299 0 None None Calcium/calmodulin-dependent protein kinase type II subunit alpha Homo sapiens
CAMK CAMK2A KCC2A_HUMAN 2VZ6B 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii FEF Type1 9 - 300 0 None None Calcium/calmodulin-dependent protein kinase type II subunit alpha Homo sapiens
CAMK CHEK1 CHK1_HUMAN 8E80A 1.49 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii UUF Type1 8 - 271 0 None N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S Serine/threonine-protein kinase Chk1 Homo sapiens
CAMK CHEK2 CHK2_HUMAN 2YCFA 1.77 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_oooo YCF Type1 210 - 510 0 None None Serine/threonine-protein kinase Chk2 Homo sapiens
CAMK DAPK1 DAPK1_HUMAN 6AARA 1.95 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_iooi 9TF Type1 2 - 277 0 None None Death-associated protein kinase 1 Homo sapiens
CAMK MAPKAPK2 MAPK2_HUMAN 3M42A 2.68 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn HGF Type1 47 - 364 0 None P237G MAP kinase-activated protein kinase 2 Homo sapiens
CAMK MELK MELK_HUMAN 5IH9A 1.79 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_nnnn 6BF Type1 3 - 327 0 None None Maternal embryonic leucine zipper kinase Homo sapiens
CAMK PIM1 PIM1_HUMAN 5KGIA 2.13 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 6SF Type1 33 - 305 0 None None Serine/threonine-protein kinase pim-1 Homo sapiens
CAMK PIM1 PIM1_HUMAN 6L13A 2.24 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii E2F Type1 33 - 305 0 SEP261 None Serine/threonine-protein kinase pim-1 Homo sapiens
CAMK PIM1 PIM1_HUMAN 2O65A 2.85 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii MYF Type1 33 - 306 0 None None Serine/threonine-protein kinase pim-1 Homo sapiens
CAMK PIM1 PIM1_HUMAN 8R0WA 1.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii XGF Type1 33 - 305 0 SEP261 R250G Serine/threonine-protein kinase pim-1 Homo sapiens
CAMK PIM1 PIM1_HUMAN 8AFRA 2.15 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii M0F Type1 33 - 305 0 SEP261 R250G Serine/threonine-protein kinase pim-1 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BU5B 3.134 Inactive DFGin‑ABAminus in-out in-out nonTYR APEdihe_aaiii APEdist_oiii RMF Type1 713 - 1044 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BU5H 3.134 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RMF Type1 713 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BUNB 3.08 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RNF Type1 715 - 1041 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BUNH 3.08 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RNF Type1 715 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 9FMRE 3.9 Inactive DFGin‑ABAminus in-out in-out nonTYR APEdihe_aaiii APEdist_oiii RMF Type1 714 - 1042 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 9FMRH 3.9 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RMF Type1 714 - 1044 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BUNE 3.08 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii RNF Type1 715 - 1039 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8P81A 2.68 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii RMF Type1 716 - 1035 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 8BU5E 3.134 Inactive DFGin‑None in-out in-out nonTYR APEdihe_aaiii APEdist_oiii RMF Type1 713 - 1043 0 TPO893 K965R Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK12 CDK12_HUMAN 9FMRB 3.9 Inactive DFGin‑None in-out in-in nonTYR APEdihe_aaiii APEdist_iiii RMF Type1 714 - 1047 0 TPO893 None Cyclin-dependent kinase 12 Homo sapiens
CMGC CDK16 CDK16_HUMAN 3MTLA 2.4 Inactive DFGout‑None in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn FEF Type1 163 - 473 0 None S319D Cyclin-dependent kinase 16 Homo sapiens
CMGC CDK2 CDK2_HUMAN 9ESWA 2.38 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii IJF, IJF, IJF, IJF Allosteric, Type1, Allosteric, Allosteric 1 - 294 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 9ESWC 2.38 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii IJF, IJF, IJF, IJF Allosteric, Type1, Allosteric, Allosteric 1 - 296 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 9OB4A 1.95 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1CAF Type1 1 - 298 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 4BCQA 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii TJF Type1 1 - 295 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 4BCQC 2.4 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii TJF Type1 1 - 294 0 TPO160 None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 7S9XA 1.69 Inactive DFGin‑BLBminus out-out out-out nonTYR APEdihe_aaiii APEdist_nnoo 8KF Type3 3 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 2W1HA 2.15 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_nnno L0F Type1 1 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 2R3IA 1.28 Inactive DFGin‑BLBtrans out-out out-out nonTYR APEdihe_aaioi APEdist_oooo SCF Type1 1 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK2 CDK2_HUMAN 5IEXA 2.03 Inactive None‑None out-out out-out nonTYR APEdihe_aaiii APEdist_nnno 6AF Type1 1 - 298 0 None None Cyclin-dependent kinase 2 Homo sapiens
CMGC CDK6 CDK6_HUMAN 9PE7A 2.05 Inactive DFGin‑BLBplus out-out none-out nonTYR APEdihe_aaiii APEdist_nnoo A1CIF Type1 10 - 301 0 None E21V,K26T,T106R,Q149E Cyclin-dependent kinase 6 Homo sapiens
CMGC CDK7 CDK7_HUMAN 8P71J 2.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii X4F Type1 10 - 310 0 None None Cyclin-dependent kinase 7 Homo sapiens
CMGC CDK8 CDK8_HUMAN 9H8SA 2.157 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn A1ITF Type1 1 - 362 0 None None Cyclin-dependent kinase 8 Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 8AEMA 1.6 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii LVF, ATP Allosteric, ATPlike 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 9EPWB 2.3 Active DFGin‑BLAminus out-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1H6F Type1 3 - 333 0 None None Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 2ZJWA 2.4 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii REF Type1 1 - 332 0 None None Casein kinase II subunit alpha Homo sapiens
CMGC CSNK2A1 CSK21_HUMAN 7I8AA 1.84 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1B0F Type1 3 - 329 0 None R21S,K74A,K75A,K76A Casein kinase II subunit alpha Homo sapiens
CMGC DYRK1A DYR1A_HUMAN 6A1FA 1.5 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 9OF Type1 134 - 483 0 PTR321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A Homo sapiens
CMGC DYRK2 DYRK2_HUMAN 7DH9A 2.194 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii H7F Type1 215 - 538 0 PTR382,SEP458 None Dual specificity tyrosine-phosphorylation-regulated kinase 2 Homo sapiens
CMGC GSK3B GSK3B_HUMAN 9PE9A 2.11 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii A1CIF Type1 36 - 382 0 PTR216 None Glycogen synthase kinase-3 beta Homo sapiens
CMGC GSK3B GSK3B_HUMAN 9PE9B 2.11 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii A1CIF Type1 36 - 382 0 PTR216 None Glycogen synthase kinase-3 beta Homo sapiens
CMGC GSK3B GSK3B_HUMAN 4PTEA 2.033 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 2WF Type1 36 - 382 0 None None Glycogen synthase kinase-3 beta Homo sapiens
CMGC GSK3B GSK3B_HUMAN 4PTEB 2.033 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 2WF Type1 36 - 385 0 None None Glycogen synthase kinase-3 beta Homo sapiens
CMGC MAPK1 MK01_HUMAN 5BVDA 1.9 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_nnnn 4VF Type1 9 - 358 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 8AO6A 1.811 Inactive DFGin‑BLAminus out-in in-out nonTYR APEdihe_aaiii APEdist_oiii N9F Type1 11 - 356 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK1 MK01_HUMAN 8AO9A 1.624 Inactive DFGin‑BLAminus out-out in-out nonTYR APEdihe_aaiii APEdist_oiii N4F Type1 11 - 356 0 None None Mitogen-activated protein kinase 1 Homo sapiens
CMGC MAPK10 MK10_HUMAN 3CGFA 3.0 Inactive DFGin‑ABAminus in-out none-out nonTYR APEdihe_aaiii APEdist_oooo JNF Type1 45 - 400 0 None None Mitogen-activated protein kinase 10 Homo sapiens
CMGC MAPK10 MK10_HUMAN 7YL1A 2.48 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaiii APEdist_oooo J6F Type1 45 - 400 0 None None Mitogen-activated protein kinase 10 Homo sapiens
CMGC MAPK14 MK14_HUMAN 6ZQSA 1.95 Inactive DFGin‑BLAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii 3FF Type1 4 - 353 0 TPO180,PTR182 None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 5XYYA 1.7 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo P0F Type1.5_Back 4 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 2QD9A 1.7 Inactive DFGin‑BLBplus in-in none-none nonTYR APEdihe_aannn APEdist_nnnn LGF Type1 5 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3QUDA 2.0 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaoii APEdist_nnoo N3F Type1 4 - 354 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3QUEA 2.7 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaoii APEdist_nnoo 3FF Type1 5 - 353 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 4R3CA 2.06 Inactive DFGin‑None in-out none-out nonTYR APEdihe_aaoii APEdist_nnno 3GF, 3GF Type1, Allosteric 4 - 352 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3L8SA 2.35 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaooi APEdist_nnno BFF Type1 4 - 353 0 None C119S,C162S,A172C,F327L Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK14 MK14_HUMAN 3UVRA 2.1 Inactive DFGout‑None in-in none-out nonTYR APEdihe_aaoii APEdist_nnno 06F Type2 5 - 351 0 None None Mitogen-activated protein kinase 14 Homo sapiens
CMGC MAPK8 MK08_HUMAN 8PTAA 2.41 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaioi APEdist_iooo CIF Type1 8 - 363 0 None None Mitogen-activated protein kinase 8 Homo sapiens
CMGC MAPK8 MK08_HUMAN 8PTAB 2.41 Inactive DFGin‑ABAminus in-in none-out nonTYR APEdihe_aaioi APEdist_iioo CIF Type1 7 - 363 0 None None Mitogen-activated protein kinase 8 Homo sapiens
CMGC MAPK8 MK08_HUMAN 8PTAC 2.41 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaioi APEdist_nnoo CIF Type1 8 - 361 0 None None Mitogen-activated protein kinase 8 Homo sapiens
CMGC MAPK9 MK09_HUMAN 3E7OA 2.14 Inactive DFGin‑ABAminus in-in out-out nonTYR APEdihe_aaiio APEdist_oooo 35F Type1 9 - 361 0 None C177S,C222S,K250A,K251A,K265A,K270A Mitogen-activated protein kinase 9 Homo sapiens
CMGC MAPK9 MK09_HUMAN 3E7OB 2.14 Inactive DFGin‑ABAminus in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn 35F Type1 8 - 362 0 None C177S,C222S,K250A,K251A,K265A,K270A Mitogen-activated protein kinase 9 Homo sapiens
OTHER CDC7 CDC7_HUMAN 6YA8A 1.79 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aaiii APEdist_nnni ADP, BEF ATPlike, Allosteric 38 - 572 0 None None Cell division cycle 7-related protein kinase Homo sapiens
OTHER GAK GAK_HUMAN 4C57A 2.55 Inactive DFGin‑ABAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii FEF Type1 25 - 334 0 None None Cyclin-G-associated kinase Homo sapiens
OTHER GAK GAK_HUMAN 4C57B 2.55 Inactive DFGin‑ABAminus out-out in-in nonTYR APEdihe_aaiii APEdist_iiii FEF Type1 27 - 334 0 None None Cyclin-G-associated kinase Homo sapiens
OTHER GAK GAK_HUMAN 4C59A 2.8 Inactive DFGin‑ABAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn FEF Type1 27 - 333 0 None None Cyclin-G-associated kinase Homo sapiens
OTHER HASPIN HASP_HUMAN 9FLTA 2.4 Active DFGin‑BLAminus in-in in-na noAPE APEdihe_aaaaa APEdist_aaaa A1IDF Type1 471 - 798 0 None None Serine/threonine-protein kinase haspin Homo sapiens
OTHER TTK TTK_HUMAN 4JS8A 1.94 Inactive DFGin‑ABAminus in-out out-out nonTYR APEdihe_aaini APEdist_nnoo 1PF Type1 515 - 793 0 TPO675,TPO686 None Dual specificity protein kinase TTK Homo sapiens
OTHER TTK TTK_HUMAN 7CHMA 2.65 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaoni APEdist_nnoo FZF Type1 516 - 794 0 TPO675,TPO686 None Dual specificity protein kinase TTK Homo sapiens
OTHER ULK1 ULK1_HUMAN 4WNOA 1.56 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 3RF Type1 8 - 280 0 TPO180 E37A,K38A Serine/threonine-protein kinase ULK1 Homo sapiens
STE MAP2K1 MP2K1_HUMAN 7UMBC 3.231 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaooo APEdist_oooo ANP, U9F ATPlike, Type3 41 - 381 0 None None Dual specificity mitogen-activated protein kinase kinase 1 Homo sapiens
STE MAP2K7 MP2K7_HUMAN 6YG3A 2.05 None DFGin‑BLAminus in-na in-none nonTYR APEdihe_aannn APEdist_nnnn 6HF Type1 103 - 400 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8FH4A 1.827 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo XXF Type1 4 - 293 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8FH4B 1.827 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo XXF Type1 6 - 302 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8FH4C 1.827 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_oooo XXF Type1 1 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8FH4D 1.827 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno XXF Type1 8 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 9QT6A 1.76 Inactive DFGin‑None out-out out-out nonTYR APEdihe_aaiii APEdist_iioo A1JAF Type1 6 - 292 0 None T165E,S171E Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K1 M4K1_HUMAN 8CIJA 2.821 Inactive DFGout‑None out-out none-none nonTYR APEdihe_aaiii APEdist_nnni USF Type1 14 - 294 0 None None Mitogen-activated protein kinase kinase kinase kinase 1 Homo sapiens
STE MAP4K4 M4K4_HUMAN 5DI1A 2.9 Inactive DFGin‑BLBplus in-out none-out nonTYR APEdihe_aaioi APEdist_nnno 5DF Type1 13 - 309 0 None None Mitogen-activated protein kinase kinase kinase kinase 4 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 3MTFA 2.15 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi A3F Type1 203 - 498 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 3MTFB 2.15 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi A3F Type1 202 - 499 0 None Q207D Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 6EIXA 2.3 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi A3F Type1 192 - 503 0 None Q207E Activin receptor type-1 Homo sapiens
TKL ACVR1 ACVR1_HUMAN 8PODA 2.59 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi 7IO, F Type1, Allosteric 172 - 498 0 None None Activin receptor type-1 Homo sapiens
TKL BRAF BRAF_HUMAN 4YHTA 3.05 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnno 4EF Type1 449 - 719 0 None I543T,I544N,I551T,L706T,L716T Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 4YHTB 3.05 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnno 4EF Type1 449 - 720 0 None I543T,I544N,I551T,L706T,L716T Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 3Q96A 3.1 Inactive DFGout‑BBAminus in-in none-none nonTYR APEdihe_aanii APEdist_nnnn 0NF Type2 449 - 722 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL BRAF BRAF_HUMAN 3Q96B 3.1 Inactive DFGout‑BBAminus in-in out-out nonTYR APEdihe_aaiii APEdist_nnno 0NF Type2 449 - 720 0 None None Serine/threonine-protein kinase B-raf Homo sapiens
TKL IRAK4 IRAK4_HUMAN 4YP8A 2.641 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 4GF Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 4YP8B 2.641 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4GF Type1 161 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 4YP8C 2.641 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4GF Type1 164 - 460 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 4YP8D 2.641 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii 4GF Type1 164 - 459 0 TPO342,TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 6LXYA 2.19 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii EXF Type1 163 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 6LXYB 2.19 None DFGin‑BLAminus in-none in-in nonTYR APEdihe_aaiii APEdist_iiii EXF Type1 163 - 459 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 6LXYD 2.19 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii EXF Type1 162 - 459 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL IRAK4 IRAK4_HUMAN 6LXYE 2.19 Inactive DFGin‑BLAminus in-out in-in nonTYR APEdihe_aaiii APEdist_iiii EXF Type1 164 - 458 0 TPO345,SEP346 None Interleukin-1 receptor-associated kinase 4 Homo sapiens
TKL MAP3K12 M3K12_HUMAN 5CEQA 1.911 Inactive DFGin‑BLBplus out-na none-out nonTYR APEdihe_aaooi APEdist_nnno 50F Type1 117 - 398 0 None None Mitogen-activated protein kinase kinase kinase 12 Homo sapiens
TKL MAP3K7 M3K7_HUMAN 5J9LA 2.752 Inactive DFGout‑None in-out none-out nonTYR APEdihe_aaoii APEdist_nnno 6HF Type1 31 - 496 0 None None Mitogen-activated protein kinase kinase kinase 7 Homo sapiens
TKL RIPK1 RIPK1_HUMAN 7FCZA 2.21 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaiii APEdist_nnno 3IF Type3 10 - 294 0 None C34A,C127A,C233A,C240A Receptor-interacting serine/threonine-protein kinase 1 Homo sapiens
TKL RIPK1 RIPK1_HUMAN 7FCZB 2.21 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_nnno 3IF Type3 7 - 294 0 None C34A,C127A,C233A,C240A Receptor-interacting serine/threonine-protein kinase 1 Homo sapiens
TKL TGFBR1 TGFR1_HUMAN 2WOUA 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii ZZF Type1 200 - 496 0 None None TGF-beta receptor type-1 Homo sapiens
TKL TGFBR1 TGFR1_HUMAN 3FAAA 3.35 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 55F Type1 171 - 500 0 None None TGF-beta receptor type-1 Homo sapiens
TKL TGFBR1 TGFR1_HUMAN 3FAAB 3.35 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 55F Type1 171 - 501 0 None None TGF-beta receptor type-1 Homo sapiens
TKL TGFBR1 TGFR1_HUMAN 3FAAC 3.35 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiio APEdist_iiii 55F Type1 171 - 500 0 None None TGF-beta receptor type-1 Homo sapiens
TKL TGFBR1 TGFR1_HUMAN 3FAAD 3.35 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 55F Type1 171 - 500 0 None None TGF-beta receptor type-1 Homo sapiens
TKL TGFBR1 TGFR1_HUMAN 3FAAE 3.35 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 55F Type1 171 - 500 0 None None TGF-beta receptor type-1 Homo sapiens
TKL TGFBR2 TGFR2_HUMAN 7DV6A 2.39 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii HJF Type1 240 - 543 0 None E431A,R433A,E485A,K488A,R493A,R495A TGF-beta receptor type-2 Homo sapiens
TYR ALK ALK_HUMAN 4CCUA 2.0 Inactive DFGin‑ABAminus in-out out-out TYR APEdihe_oiiai APEdist_aaai AWF Type1 1093 - 1402 0 None None ALK tyrosine kinase receptor Homo sapiens
TYR ALK ALK_HUMAN 4FNZA 2.6 Inactive DFGin‑ABAminus in-in none-out TYR APEdihe_oiiai APEdist_aaai NZF Type1 1093 - 1402 0 None C1097S ALK tyrosine kinase receptor Homo sapiens
TYR ALK ALK_HUMAN 4DCEA 2.03 Inactive DFGin‑None in-in none-out TYR APEdihe_oiiai APEdist_aaai 0JF Type1 1093 - 1402 0 None C1097S ALK tyrosine kinase receptor Homo sapiens
TYR ALK ALK_HUMAN 4DCEB 2.03 Inactive DFGin‑None in-in none-out TYR APEdihe_oiiai APEdist_aaao 0JF Type1 1094 - 1402 0 None C1097S ALK tyrosine kinase receptor Homo sapiens
TYR BTK BTK_HUMAN 5FBNC 1.8 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 5WF, 5WE Type1.5_Front, Allosteric 395 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
TYR BTK BTK_HUMAN 5FBND 1.8 Inactive DFGin‑BLBplus out-out out-none TYR APEdihe_nniai APEdist_aaai 5WF, 5WE, 5WE, 5WE Type1.5_Front, Allosteric, Allosteric, Allosteric 394 - 658 0 None None Tyrosine-protein kinase BTK Homo sapiens
TYR DDR1 DDR1_HUMAN 5SAUA 1.8 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai 1IF Type2 604 - 912 0 None None Epithelial discoidin domain-containing receptor 1 Homo sapiens
TYR EPHA2 EPHA2_HUMAN 8BOCA 1.9 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai QUF Type2 605 - 888 0 None None Ephrin type-A receptor 2 Homo sapiens
TYR EPHB4 EPHB4_HUMAN 2X9FA 1.75 Inactive DFGin‑BLBminus in-in out-in TYR APEdihe_iiiai APEdist_aaai X9F Type1 608 - 888 0 None Y774E Ephrin type-B receptor 4 Homo sapiens
TYR FGFR1 FGFR1_HUMAN 9UHIA 1.76 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_iioai APEdist_aaao A1EPF Type1 458 - 764 0 None None Fibroblast growth factor receptor 1 Homo sapiens
TYR FGFR1 FGFR1_HUMAN 9UHIB 1.76 Inactive DFGin‑BLAplus in-in none-out TYR APEdihe_iioai APEdist_aaao A1EPF Type1 458 - 763 0 None None Fibroblast growth factor receptor 1 Homo sapiens
TYR FGFR1 FGFR1_HUMAN 3C4FA 2.07 Inactive DFGin‑BLAplus in-out out-out TYR APEdihe_iioai APEdist_aaao C4F Type1.5_Back 464 - 765 0 None C488A Fibroblast growth factor receptor 1 Homo sapiens
TYR FGFR1 FGFR1_HUMAN 3C4FB 2.07 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_iioai APEdist_aaao C4F Type1.5_Back 464 - 765 0 None C488A Fibroblast growth factor receptor 1 Homo sapiens
TYR FGFR1 FGFR1_HUMAN 5EW8A 1.63 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_iioai APEdist_aaao 5SF Type1.5_Back 464 - 765 0 None None Fibroblast growth factor receptor 1 Homo sapiens
TYR FGFR1 FGFR1_HUMAN 5EW8B 1.63 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_iioai APEdist_aaao 5SF Type1.5_Back 461 - 765 0 None None Fibroblast growth factor receptor 1 Homo sapiens
TYR FGFR1 FGFR1_HUMAN 7WCLA 2.495 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_iioai APEdist_aaao 8ZF Type1.5_Back 459 - 764 0 None C584S Fibroblast growth factor receptor 1 Homo sapiens
TYR FGFR1 FGFR1_HUMAN 7WCLB 2.495 Inactive DFGin‑BLAplus in-in none-out TYR APEdihe_iioai APEdist_aaao 8ZF Type1.5_Back 458 - 763 0 None C584S Fibroblast growth factor receptor 1 Homo sapiens
TYR FGFR3 FGFR3_HUMAN 8UDTA 2.829 Inactive DFGin‑BLAplus in-out out-out TYR APEdihe_nnoai APEdist_aaao MLT, MLT, WGF Allosteric, Allosteric, Type1.5_Front 457 - 756 0 None P572S,P573G Fibroblast growth factor receptor 3 Homo sapiens
TYR FGFR3 FGFR3_HUMAN 8UDTB 2.829 Inactive DFGin‑BLAplus in-out out-out TYR APEdihe_nooai APEdist_aaao WGF Type1.5_Front 457 - 754 0 None P572S,P573G Fibroblast growth factor receptor 3 Homo sapiens
TYR FGFR3 FGFR3_HUMAN 8UDTC 2.829 Inactive DFGin‑BLAplus in-out out-out TYR APEdihe_nooai APEdist_aaao WGF Type1.5_Front 457 - 756 0 None P572S,P573G Fibroblast growth factor receptor 3 Homo sapiens
TYR FGFR4 FGFR4_HUMAN 7WCXA 2.175 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_iioai APEdist_aaao 90F Type1 453 - 752 0 None C477A,R664E Fibroblast growth factor receptor 4 Homo sapiens
TYR FGFR4 FGFR4_HUMAN 7WCWA 2.317 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_iioai APEdist_aaao 90F Type1 453 - 752 0 None C477A,R664E Fibroblast growth factor receptor 4 Homo sapiens
TYR FGFR4 FGFR4_HUMAN 6JPJA 2.638 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_iioai APEdist_aaao FGF Type1 454 - 752 0 None C477A,R664E Fibroblast growth factor receptor 4 Homo sapiens
TYR FGFR4 FGFR4_HUMAN 7VJLA 2.9 Inactive DFGin‑BLAplus in-in none-none TYR APEdihe_nnnai APEdist_aaan 7IF Type1 454 - 753 0 None None Fibroblast growth factor receptor 4 Homo sapiens
TYR FGFR4 FGFR4_HUMAN 7VJLB 2.9 Inactive DFGin‑BLAplus in-in none-none TYR APEdihe_nnnai APEdist_aaan 7IF Type1 453 - 753 0 None None Fibroblast growth factor receptor 4 Homo sapiens
TYR FGFR4 FGFR4_HUMAN 6YI8A 2.13 Inactive DFGin‑BLAplus in-in none-out TYR APEdihe_niiai APEdist_aaao FGF Type1 453 - 753 0 None None Fibroblast growth factor receptor 4 Homo sapiens
TYR FGFR4 FGFR4_HUMAN 6YI8B 2.13 Inactive DFGin‑BLAplus in-in none-out TYR APEdihe_nniai APEdist_aaao FGF Type1 451 - 752 0 None None Fibroblast growth factor receptor 4 Homo sapiens
TYR FGFR4 FGFR4_HUMAN 7WCTA 2.106 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_iioai APEdist_aaao 90F Type1 453 - 752 0 None R664E Fibroblast growth factor receptor 4 Homo sapiens
TYR FGFR4 FGFR4_HUMAN 5XFJA 3.25 Inactive DFGin‑None in-out none-out TYR APEdihe_nniai APEdist_aaao 6LF Type1 453 - 750 0 None V550M Fibroblast growth factor receptor 4 Homo sapiens
TYR FGFR4 FGFR4_HUMAN 5XFFA 2.7 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao 6LF Type1 453 - 750 0 None V550L Fibroblast growth factor receptor 4 Homo sapiens
TYR FGFR4 FGFR4_HUMAN 5JKGA 2.352 Inactive DFGin‑None in-in none-out TYR APEdihe_nniai APEdist_aaao 6LF Type1 453 - 750 0 None None Fibroblast growth factor receptor 4 Homo sapiens
TYR FLT3 FLT3_HUMAN 6JQRA 2.2 Inactive DFGout‑None in-in none-in TYR APEdihe_iiiai APEdist_aaai C6F Type1 571 - 951 0 None None Receptor-type tyrosine-protein kinase FLT3 Homo sapiens
TYR HCK HCK_HUMAN 3VS4A 2.747 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao VSF Type1.5_Back 81 - 526 0 PTR522 Q523E,Q524E,Q525I Tyrosine-protein kinase HCK Homo sapiens
TYR HCK HCK_HUMAN 3VS4B 2.747 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_nniai APEdist_aaao VSF Type1.5_Back 81 - 526 0 PTR522 Q523E,Q524E,Q525I Tyrosine-protein kinase HCK Homo sapiens
TYR JAK2-1 JAK2_HUMAN 8B9EA 1.5 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao Q7F Type1 536 - 809 0 None W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR JAK2-1 JAK2_HUMAN 8B9HA 1.5 Pseudo DFGin‑None out-na out-out TYR APEdihe_oooao APEdist_aaao Q7F Type1 536 - 809 0 None W659A,W777A,F794H Tyrosine-protein kinase JAK2 Homo sapiens
TYR KDR VGFR2_HUMAN 3VO3A 1.52 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai 0KF Type2 812 - 1168 0 None None Vascular endothelial growth factor receptor 2 Homo sapiens
TYR KDR VGFR2_HUMAN 1YWNA 1.71 Inactive None‑None in-in none-out TYR APEdihe_iioai APEdist_aaao LIF Type1 820 - 1171 0 PTR1054,PTR1059 E990V Vascular endothelial growth factor receptor 2 Homo sapiens
TYR LCK LCK_HUMAN 2ZM1A 2.1 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai KSF Type1 231 - 501 0 PTR394 None Tyrosine-protein kinase Lck Homo sapiens
TYR MERTK MERTK_HUMAN 9BHIA 2.07 Inactive DFGin‑BLAminus out-out in-out TYR APEdihe_oiiai APEdist_aaai A1APF Type1.5_Front 578 - 864 0 None None Tyrosine-protein kinase Mer Homo sapiens
TYR MERTK MERTK_HUMAN 7AB1A 1.93 Inactive DFGin‑None out-out none-none TYR APEdihe_nnnai APEdist_aaan C6F Type1 571 - 862 0 None K591R,K693R,K702R,K856R Tyrosine-protein kinase Mer Homo sapiens
TYR MET MET_HUMAN 3ZCLA 1.4 Inactive DFGin‑BLBplus out-out out-in TYR APEdihe_iiiai APEdist_aaai 5TF Type1 1052 - 1345 0 None None Hepatocyte growth factor receptor Homo sapiens
TYR MET MET_HUMAN 4MXCA 1.632 Inactive DFGout‑BBAminus in-in out-in TYR APEdihe_iiiai APEdist_aaai DWF Type2 1052 - 1346 0 None None Hepatocyte growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 5H3QA 2.1 Inactive DFGout‑BBAminus in-out out-in TYR APEdihe_iiiai APEdist_aaai 7HF Type1 484 - 796 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR NTRK1 NTRK1_HUMAN 5KMJA 2.04 Inactive DFGout‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai 6UF Type3 486 - 795 0 None None High affinity nerve growth factor receptor Homo sapiens
TYR PTK2 FAK1_HUMAN 4EBWA 2.65 Inactive DFGinter‑None in-in none-out TYR APEdihe_niiai APEdist_aaao 0PF Type1 411 - 686 0 None None Focal adhesion kinase 1 Homo sapiens
TYR SYK KSYK_HUMAN 5LMBA 1.95 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 6ZF Type1 364 - 634 0 PTR525 None Tyrosine-protein kinase SYK Homo sapiens
TYR SYK KSYK_HUMAN 5LMBB 1.95 None DFGin‑BLAminus in-in in-none TYR APEdihe_nniai APEdist_aaai 6ZF Type1 364 - 630 0 PTR525 None Tyrosine-protein kinase SYK Homo sapiens
TYR SYK KSYK_HUMAN 4YJOA 1.6 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 4DF Type1 363 - 632 0 None None Tyrosine-protein kinase SYK Homo sapiens
TYR SYK KSYK_HUMAN 5TT7A 1.77 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 7KF Type1 358 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
TYR SYK KSYK_HUMAN 4FYOA 1.4 None DFGin‑BLAminus in-in in-none TYR APEdihe_niiai APEdist_aaai 0VF Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
TYR SYK KSYK_HUMAN 4GFGA 2.35 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 0XF Type1 363 - 635 0 None None Tyrosine-protein kinase SYK Homo sapiens
CMGC MAPK14 MK14_MOUSE 5R9OA 1.6 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo 54F Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
TKL RIPK3 RIPK3_MOUSE 9LVHA 2.38 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn MYF Type1 13 - 312 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
TKL RIPK3 RIPK3_MOUSE 9LVHB 2.38 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_nnnn MYF Type1 13 - 312 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
OTHER CDC7 CDC7_YEAST 7PT78 3.8 Inactive DFGin‑ABAminus in-out in-out nonTYR APEdihe_aaiio APEdist_iiii ADP, BEF ATPlike, Allosteric 10 - 475 0 None None Cell division control protein 7 Saccharomyces cerevisiae
CMGC GSK3B A0A125YY75_TOXGG 9HVXA 2.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii A1IYF Type1 46 - 384 0 PTR211 None Putative cell-cycle-associated protein kinase GSK Toxoplasma gondii
CMGC GSK3B A0A125YY75_TOXGG 9HW6A 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_niio A1IYF Type1 46 - 384 0 PTR211,SEP257 None Putative cell-cycle-associated protein kinase GSK Toxoplasma gondii
CMGC GSK3B A0A125YY75_TOXGG 9HW6B 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooi APEdist_nnio A1IYF Type1 46 - 384 0 PTR211 None Putative cell-cycle-associated protein kinase GSK Toxoplasma gondii
CMGC GSK3B A0A125YY75_TOXGG 9HW6D 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooo APEdist_nnio A1IYF Type1 46 - 384 0 PTR211,SEP257 None Putative cell-cycle-associated protein kinase GSK Toxoplasma gondii
CMGC GSK3B A0A125YY75_TOXGG 9HW6F 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_niio A1IYF Type1 46 - 384 0 PTR211 None Putative cell-cycle-associated protein kinase GSK Toxoplasma gondii

Ligand: F

Total number of chains: 13
Active chains: 1
Total number of genes: 6
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 8 61.5% 9RETA
DFGin ABAminus 2 15.4% 7PIEA
DFGout BBAminus 2 15.4% 5SYSA
DFGin BLBminus 1 7.7% 5R9OA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
AGC PRKACA KAPCA_CRIGR 7PIEA 1.427 Inactive DFGin‑ABAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii 7QF Type1 1 - 351 0 SEP11,SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
AGC PRKACA KAPCA_CRIGR 9RETA 1.75 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1JEF Allosteric 13 - 351 0 SEP140,TPO198,SEP339 None cAMP-dependent protein kinase catalytic subunit alpha Cricetulus griseus
TYR SRC SRC_CHICK 5SYSA 2.8 Inactive DFGout‑BBAminus in-in none-none TYR APEdihe_nnnai APEdist_aaan 72F Type2 258 - 533 0 None V281C Proto-oncogene tyrosine-protein kinase Src Gallus gallus
TYR SRC SRC_CHICK 5SYSB 2.8 Inactive DFGout‑BBAminus in-in none-none TYR APEdihe_nnnai APEdist_aaan 72F Type2 258 - 533 0 None V281C Proto-oncogene tyrosine-protein kinase Src Gallus gallus
CMGC MAPK14 MK14_MOUSE 5R9OA 1.6 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaooi APEdist_oooo 54F Allosteric 5 - 352 0 None None Mitogen-activated protein kinase 14 Mus musculus
TKL RIPK3 RIPK3_MOUSE 9LVHA 2.38 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aannn APEdist_nnnn MYF Type1 13 - 312 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
TKL RIPK3 RIPK3_MOUSE 9LVHB 2.38 None DFGin‑BLAminus in-in in-none nonTYR APEdihe_aanii APEdist_nnnn MYF Type1 13 - 312 0 None None Receptor-interacting serine/threonine-protein kinase 3 Mus musculus
OTHER CDC7 CDC7_YEAST 7PT78 3.8 Inactive DFGin‑ABAminus in-out in-out nonTYR APEdihe_aaiio APEdist_iiii ADP, BEF ATPlike, Allosteric 10 - 475 0 None None Cell division control protein 7 Saccharomyces cerevisiae
CMGC GSK3B A0A125YY75_TOXGG 9HVXA 2.1 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iiii A1IYF Type1 46 - 384 0 PTR211 None Putative cell-cycle-associated protein kinase GSK Toxoplasma gondii
CMGC GSK3B A0A125YY75_TOXGG 9HW6A 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_niio A1IYF Type1 46 - 384 0 PTR211,SEP257 None Putative cell-cycle-associated protein kinase GSK Toxoplasma gondii
CMGC GSK3B A0A125YY75_TOXGG 9HW6B 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooi APEdist_nnio A1IYF Type1 46 - 384 0 PTR211 None Putative cell-cycle-associated protein kinase GSK Toxoplasma gondii
CMGC GSK3B A0A125YY75_TOXGG 9HW6D 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaooo APEdist_nnio A1IYF Type1 46 - 384 0 PTR211,SEP257 None Putative cell-cycle-associated protein kinase GSK Toxoplasma gondii
CMGC GSK3B A0A125YY75_TOXGG 9HW6F 2.9 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_niio A1IYF Type1 46 - 384 0 PTR211 None Putative cell-cycle-associated protein kinase GSK Toxoplasma gondii