Protein kinases in complex with F

Total number of genes: 61
Total number of chains: 161
Spatial Dihedral Chains Representative
DFGin BLAminus 75 4AW0A
DFGin BLAplus 17 7WCTA
DFGin ABAminus 19 4C57A
DFGin BLBminus 3 5XYYA
DFGin BLBplus 9 3ZCLA
DFGin BLBtrans 2 2R3IA
DFGin None 16 8B9EA
DFGinter None 1 4EBWA
DFGout BBAminus 8 4MXCA
DFGout None 9 3VO3A
None None 2 5IEXA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
AGC AKT1 AKT1_HUMAN RAC-alpha serine/threonine-protein kinase 4EKLA 2.0 Active DFGin BLAminus in-in in-in 0RF Type1
AGC GRK5 GRK5_HUMAN G protein-coupled receptor kinase 5 9BREA 2.8 Active DFGin BLAminus in-in in-in W3F Type1
AGC GRK5 GRK5_HUMAN G protein-coupled receptor kinase 5 8UAQA 2.8 Inactive DFGin None in-in in-in W3F Type1
AGC PDPK1 PDPK1_HUMAN 3-phosphoinositide-dependent protein kinase 1 4AW0A 1.43 Active DFGin BLAminus in-in in-in ATP MJF Type1 Allosteric
AGC PRKCH KPCL_HUMAN Protein kinase C eta type 8FP1A 1.85 Active DFGin BLAminus in-in in-in XXF Type1
CAMK AURKA AURKA_HUMAN Aurora kinase A 8C1DA 2.115 Inactive DFGin BLAminus in-in in-out T2F ADP T5L Allosteric Type1 Allosteric
CAMK AURKA AURKA_HUMAN Aurora kinase A 2W1FA 2.85 Inactive DFGin BLAminus out-out in-out L0F Type1
CAMK AURKA AURKA_HUMAN Aurora kinase A 3O51A 3.2 Inactive DFGout None out-none none-none LJF Type1.5_Front
CAMK CAMK2A KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha 2VZ6A 2.3 Active DFGin BLAminus in-in in-in FEF Type1
CAMK CAMK2A KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha 2VZ6B 2.3 Active DFGin BLAminus in-in in-in FEF Type1
CAMK CHEK1 CHK1_HUMAN Serine/threonine-protein kinase Chk1 8E80A 1.49 Active DFGin BLAminus in-in in-in UUF Type1
CAMK CHEK2 CHK2_HUMAN Serine/threonine-protein kinase Chk2 2YCFA 1.77 Inactive DFGin BLAminus in-out in-out YCF Type1
CAMK DAPK1 DAPK1_HUMAN Death-associated protein kinase 1 6AARA 1.95 Active DFGin BLAminus in-in in-in 9TF Type1
CAMK MAPKAPK2 MAPK2_HUMAN MAP kinase-activated protein kinase 2 3M42A 2.68 None DFGin BLAminus in-in in-none HGF Type1
CAMK MELK MELK_HUMAN Maternal embryonic leucine zipper kinase 5IH9A 1.79 None DFGin BLAminus in-in in-none 6BF Type1
CAMK PIM1 PIM1_HUMAN Serine/threonine-protein kinase pim-1 5KGIA 2.13 Active DFGin BLAminus in-in in-in 6SF Type1
CAMK PIM1 PIM1_HUMAN Serine/threonine-protein kinase pim-1 6L13A 2.24 Active DFGin BLAminus in-in in-in E2F Type1
CAMK PIM1 PIM1_HUMAN Serine/threonine-protein kinase pim-1 2O65A 2.85 Active DFGin BLAminus in-in in-in MYF Type1
CAMK PIM1 PIM1_HUMAN Serine/threonine-protein kinase pim-1 8R0WA 1.95 Active DFGin BLAminus in-in in-in XGF Type1
CAMK PIM1 PIM1_HUMAN Serine/threonine-protein kinase pim-1 8AFRA 2.15 Active DFGin BLAminus in-in in-in M0F Type1
CMGC CDK12 CDK12_HUMAN Cyclin-dependent kinase 12 8BU5B 3.134 Inactive DFGin ABAminus in-out in-in RMF Type1
CMGC CDK12 CDK12_HUMAN Cyclin-dependent kinase 12 8BU5H 3.134 Inactive DFGin ABAminus in-in in-in RMF Type1
CMGC CDK12 CDK12_HUMAN Cyclin-dependent kinase 12 8BUNB 3.08 Inactive DFGin ABAminus in-in in-in RNF Type1
CMGC CDK12 CDK12_HUMAN Cyclin-dependent kinase 12 8BUNH 3.08 Inactive DFGin ABAminus in-in in-in RNF Type1
CMGC CDK12 CDK12_HUMAN Cyclin-dependent kinase 12 9FMRE 3.9 Inactive DFGin ABAminus in-out in-in RMF Type1
CMGC CDK12 CDK12_HUMAN Cyclin-dependent kinase 12 9FMRH 3.9 Inactive DFGin ABAminus in-in in-in RMF Type1
CMGC CDK12 CDK12_HUMAN Cyclin-dependent kinase 12 8BUNE 3.08 Active DFGin BLAminus in-in in-in RNF Type1
CMGC CDK12 CDK12_HUMAN Cyclin-dependent kinase 12 8P81A 2.68 Active DFGin BLAminus in-in in-in RMF Type1
CMGC CDK12 CDK12_HUMAN Cyclin-dependent kinase 12 8BU5E 3.134 Inactive DFGin None in-out in-in RMF Type1
CMGC CDK12 CDK12_HUMAN Cyclin-dependent kinase 12 9FMRB 3.9 Inactive DFGin None in-out in-in RMF Type1
CMGC CDK16 CDK16_HUMAN Cyclin-dependent kinase 16 3MTLA 2.4 Inactive DFGout None in-in out-none FEF Type1
CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 9ESWA 2.38 Active DFGin BLAminus in-in in-in IJF IJF IJF IJF Allosteric Type1 Allosteric Allosteric
CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 9ESWC 2.38 Active DFGin BLAminus in-in in-in IJF IJF IJF IJF Allosteric Type1 Allosteric Allosteric
CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 9OB4A 1.95 Active DFGin BLAminus in-in in-in A1CAF Type1
CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 4BCQA 2.4 Active DFGin BLAminus in-in in-in TJF Type1
CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 4BCQC 2.4 Active DFGin BLAminus in-in in-in TJF Type1
CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 7S9XA 1.69 Inactive DFGin BLBminus out-out out-out 8KF Type3
CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 2W1HA 2.15 Inactive DFGin BLBtrans out-out out-out L0F Type1
CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 2R3IA 1.28 Inactive DFGin BLBtrans out-out out-out SCF Type1
CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 5IEXA 2.03 Inactive None None out-out out-out 6AF Type1
CMGC CDK7 CDK7_HUMAN Cyclin-dependent kinase 7 8P71J 2.0 Active DFGin BLAminus in-in in-in X4F Type1
CMGC CDK8 CDK8_HUMAN Cyclin-dependent kinase 8 9H8SA 2.157 None DFGin BLAminus in-in out-none A1ITF Type1
CMGC CSNK2A1 CSK21_HUMAN Casein kinase II subunit alpha 8AEMA 1.6 Active DFGin BLAminus in-in in-in LVF ATP Allosteric Type1
CMGC CSNK2A1 CSK21_HUMAN Casein kinase II subunit alpha 9EPWB 2.3 Active DFGin BLAminus out-in in-in A1H6F Type1
CMGC CSNK2A1 CSK21_HUMAN Casein kinase II subunit alpha 2ZJWA 2.4 Active DFGin BLAminus in-in in-in REF Type1
CMGC DYRK1A DYR1A_HUMAN Dual specificity tyrosine-phosphorylation-regulated kinase 1A 6A1FA 1.5 Active DFGin BLAminus in-in in-in 9OF Type1
CMGC DYRK2 DYRK2_HUMAN Dual specificity tyrosine-phosphorylation-regulated kinase 2 7DH9A 2.194 Active DFGin BLAminus in-in in-in H7F Type1
CMGC GSK3B GSK3B_HUMAN Glycogen synthase kinase-3 beta 4PTEA 2.033 Active DFGin BLAminus in-in in-in 2WF Type1
CMGC GSK3B GSK3B_HUMAN Glycogen synthase kinase-3 beta 4PTEB 2.033 Active DFGin BLAminus in-in in-in 2WF Type1
CMGC MAPK1 MK01_HUMAN Mitogen-activated protein kinase 1 5BVDA 1.9 None DFGin BLAminus in-in in-none 4VF Type1
CMGC MAPK1 MK01_HUMAN Mitogen-activated protein kinase 1 8AO6A 1.811 Active DFGin BLAminus out-in in-in N9F Type1
CMGC MAPK1 MK01_HUMAN Mitogen-activated protein kinase 1 8AO9A 1.624 Inactive DFGin BLAminus out-out in-in N4F Type1
CMGC MAPK10 MK10_HUMAN Mitogen-activated protein kinase 10 3CGFA 3.0 Inactive DFGin ABAminus in-out none-out JNF Type1
CMGC MAPK10 MK10_HUMAN Mitogen-activated protein kinase 10 7YL1A 2.48 Inactive DFGin ABAminus in-in out-out J6F Type1
CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 6ZQSA 1.95 Inactive DFGin BLAminus out-out in-in 3FF Type1
CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 5XYYA 1.7 Inactive DFGin BLBminus in-in out-out P0F Type1.5_Back
CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 2QD9A 1.7 Inactive DFGin BLBplus in-in none-none LGF Type1
CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 3QUDA 2.0 Inactive DFGin None in-in out-out N3F Type1
CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 3QUEA 2.7 Inactive DFGin None in-in out-out 3FF Type1
CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 4R3CA 2.06 Inactive DFGin None in-out none-out 3GF 3GF Type1 Allosteric
CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 3L8SA 2.35 Inactive DFGout None in-in none-out BFF Type1
CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 3UVRA 2.1 Inactive DFGout None in-in none-out 06F Type2
CMGC MAPK8 MK08_HUMAN Mitogen-activated protein kinase 8 8PTAA 2.41 Inactive DFGin ABAminus in-in out-out CIF Type1
CMGC MAPK8 MK08_HUMAN Mitogen-activated protein kinase 8 8PTAB 2.41 Inactive DFGin ABAminus in-in none-out CIF Type1
CMGC MAPK8 MK08_HUMAN Mitogen-activated protein kinase 8 8PTAC 2.41 Inactive DFGin ABAminus in-out out-out CIF Type1
CMGC MAPK9 MK09_HUMAN Mitogen-activated protein kinase 9 3E7OA 2.14 Inactive DFGin ABAminus in-in out-out 35F Type1
CMGC MAPK9 MK09_HUMAN Mitogen-activated protein kinase 9 3E7OB 2.14 Inactive DFGin ABAminus in-in none-none 35F Type1
OTHER CDC7 CDC7_HUMAN Cell division cycle 7-related protein kinase 6YA8A 1.79 Active DFGin BLAminus in-in in-in ADP BEF Type1 Allosteric
OTHER GAK GAK_HUMAN Cyclin-G-associated kinase 4C57A 2.55 Inactive DFGin ABAminus in-out in-in FEF Type1
OTHER GAK GAK_HUMAN Cyclin-G-associated kinase 4C57B 2.55 Inactive DFGin ABAminus out-out in-in FEF Type1
OTHER GAK GAK_HUMAN Cyclin-G-associated kinase 4C59A 2.8 Inactive DFGin ABAminus in-in in-none FEF Type1
OTHER HASPIN HASP_HUMAN Serine/threonine-protein kinase haspin 9FLTA 2.4 Active DFGin BLAminus in-in in-none A1IDF Type1
OTHER TTK TTK_HUMAN Dual specificity protein kinase TTK 4JS8A 1.94 Inactive DFGin ABAminus in-out out-out 1PF Type1
OTHER TTK TTK_HUMAN Dual specificity protein kinase TTK 7CHMA 2.65 Inactive DFGin None in-in out-out FZF Type1
OTHER ULK1 ULK1_HUMAN Serine/threonine-protein kinase ULK1 4WNOA 1.56 Active DFGin BLAminus in-in in-in 3RF Type1
STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 7UMBC 3.231 Inactive DFGin BLBplus out-out out-out ANP U9F Type1 Type3
STE MAP2K7 MP2K7_HUMAN Dual specificity mitogen-activated protein kinase kinase 7 6YG3A 2.05 None DFGin BLAminus in-in in-none 6HF Type1
STE MAP4K1 M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 8FH4A 1.827 Inactive DFGin BLAminus in-in out-out XXF Type1
STE MAP4K1 M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 8FH4B 1.827 Inactive DFGin BLAminus in-in out-out XXF Type1
STE MAP4K1 M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 8FH4C 1.827 Inactive DFGin BLAminus in-in out-out XXF Type1
STE MAP4K1 M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 8FH4D 1.827 Inactive DFGin BLAminus in-in out-out XXF Type1
STE MAP4K1 M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 9QT6A 1.76 Inactive DFGin None out-out out-out A1JAF Type1
STE MAP4K1 M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 8CIJA 2.821 Inactive DFGout None out-out none-in USF Type1
STE MAP4K4 M4K4_HUMAN Mitogen-activated protein kinase kinase kinase kinase 4 5DI1A 2.9 Inactive DFGin BLBplus in-out none-out 5DF Type1
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 3MTFA 2.15 Inactive DFGin BLAminus in-out in-in A3F Type1
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 3MTFB 2.15 Inactive DFGin BLAminus in-out in-in A3F Type1
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 6EIXA 2.3 Inactive DFGin BLAminus in-out in-in A3F Type1
TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 8PODA 2.59 Inactive DFGin BLAminus in-out in-in 7IO F Type1 Allosteric
TKL BRAF BRAF_HUMAN Serine/threonine-protein kinase B-raf 4YHTA 3.05 Inactive DFGin BLAminus in-in in-out 4EF Type1
TKL BRAF BRAF_HUMAN Serine/threonine-protein kinase B-raf 4YHTB 3.05 Inactive DFGin BLAminus in-in in-out 4EF Type1
TKL BRAF BRAF_HUMAN Serine/threonine-protein kinase B-raf 3Q96A 3.1 Inactive DFGout BBAminus in-in none-none 0NF Type2
TKL BRAF BRAF_HUMAN Serine/threonine-protein kinase B-raf 3Q96B 3.1 Inactive DFGout BBAminus in-in out-out 0NF Type2
TKL IRAK4 IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 4YP8A 2.641 Active DFGin BLAminus in-in in-in 4GF Type1
TKL IRAK4 IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 4YP8B 2.641 Inactive DFGin BLAminus in-out in-in 4GF Type1
TKL IRAK4 IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 4YP8C 2.641 Inactive DFGin BLAminus in-out in-in 4GF Type1
TKL IRAK4 IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 4YP8D 2.641 Inactive DFGin BLAminus in-out in-in 4GF Type1
TKL IRAK4 IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 6LXYA 2.19 Inactive DFGin BLAminus in-out in-in EXF Type1
TKL IRAK4 IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 6LXYB 2.19 None DFGin BLAminus in-none in-in EXF Type1
TKL IRAK4 IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 6LXYD 2.19 Inactive DFGin BLAminus in-out in-in EXF Type1
TKL IRAK4 IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 6LXYE 2.19 Inactive DFGin BLAminus in-out in-in EXF Type1
TKL MAP3K12 M3K12_HUMAN Mitogen-activated protein kinase kinase kinase 12 5CEQA 1.911 Inactive DFGin BLBplus out-out none-out 50F Type1
TKL MAP3K7 M3K7_HUMAN Mitogen-activated protein kinase kinase kinase 7 5J9LA 2.752 Inactive DFGout None in-out none-out 6HF Type1
TKL RIPK1 RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 7FCZA 2.21 Inactive DFGout BBAminus out-out out-out 3IF Type3
TKL RIPK1 RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 7FCZB 2.21 Inactive DFGout BBAminus out-out out-out 3IF Type3
TKL TGFBR1 TGFR1_HUMAN TGF-beta receptor type-1 2WOUA 2.3 Active DFGin BLAminus in-in in-in ZZF Type1
TKL TGFBR1 TGFR1_HUMAN TGF-beta receptor type-1 3FAAA 3.35 Active DFGin BLAminus in-in in-in 55F Type1
TKL TGFBR1 TGFR1_HUMAN TGF-beta receptor type-1 3FAAB 3.35 Active DFGin BLAminus in-in in-in 55F Type1
TKL TGFBR1 TGFR1_HUMAN TGF-beta receptor type-1 3FAAC 3.35 Active DFGin BLAminus in-in in-in 55F Type1
TKL TGFBR1 TGFR1_HUMAN TGF-beta receptor type-1 3FAAD 3.35 Active DFGin BLAminus in-in in-in 55F Type1
TKL TGFBR1 TGFR1_HUMAN TGF-beta receptor type-1 3FAAE 3.35 Active DFGin BLAminus in-in in-in 55F Type1
TKL TGFBR2 TGFR2_HUMAN TGF-beta receptor type-2 7DV6A 2.39 Active DFGin BLAminus in-in in-in HJF Type1
TYR ALK ALK_HUMAN ALK tyrosine kinase receptor 4CCUA 2.0 Inactive DFGin ABAminus in-out out-in AWF Type1
TYR ALK ALK_HUMAN ALK tyrosine kinase receptor 4FNZA 2.6 Inactive DFGin ABAminus in-in none-in NZF Type1
TYR ALK ALK_HUMAN ALK tyrosine kinase receptor 4DCEA 2.03 Inactive DFGin None in-in none-in 0JF Type1
TYR ALK ALK_HUMAN ALK tyrosine kinase receptor 4DCEB 2.03 Inactive DFGin None in-in none-out 0JF Type1
TYR BTK BTK_HUMAN Tyrosine-protein kinase BTK 5FBNC 1.8 Inactive DFGin BLBplus out-out out-out 5WF 5WE Type1.5_Front Allosteric
TYR BTK BTK_HUMAN Tyrosine-protein kinase BTK 5FBND 1.8 Inactive DFGin BLBplus out-out out-in 5WF 5WE 5WE 5WE Type1.5_Front Allosteric Allosteric Allosteric
TYR DDR1 DDR1_HUMAN Epithelial discoidin domain-containing receptor 1 5SAUA 1.8 Inactive DFGout BBAminus in-in out-in 1IF Type2
TYR EPHA2 EPHA2_HUMAN Ephrin type-A receptor 2 8BOCA 1.9 Inactive DFGout BBAminus in-in out-in QUF Type2
TYR EPHB4 EPHB4_HUMAN Ephrin type-B receptor 4 2X9FA 1.75 Inactive DFGin BLBminus in-in out-in X9F Type1
TYR FGFR1 FGFR1_HUMAN Fibroblast growth factor receptor 1 3C4FA 2.07 Inactive DFGin BLAplus in-out out-out C4F Type1.5_Back
TYR FGFR1 FGFR1_HUMAN Fibroblast growth factor receptor 1 3C4FB 2.07 Inactive DFGin BLAplus in-in out-out C4F Type1.5_Back
TYR FGFR1 FGFR1_HUMAN Fibroblast growth factor receptor 1 5EW8A 1.63 Inactive DFGin BLAplus in-in out-out 5SF Type1.5_Back
TYR FGFR1 FGFR1_HUMAN Fibroblast growth factor receptor 1 5EW8B 1.63 Inactive DFGin BLAplus in-in out-out 5SF Type1.5_Back
TYR FGFR1 FGFR1_HUMAN Fibroblast growth factor receptor 1 7WCLA 2.495 Inactive DFGin BLAplus in-in out-out 8ZF Type1.5_Back
TYR FGFR1 FGFR1_HUMAN Fibroblast growth factor receptor 1 7WCLB 2.495 Inactive DFGin BLAplus in-in none-out 8ZF Type1.5_Back
TYR FGFR3 FGFR3_HUMAN Fibroblast growth factor receptor 3 8UDTA 2.829 Inactive DFGin BLAplus in-out out-out MLT MLT WGF Allosteric Allosteric Type1.5_Front
TYR FGFR3 FGFR3_HUMAN Fibroblast growth factor receptor 3 8UDTB 2.829 Inactive DFGin BLAplus in-out out-out WGF Type1.5_Front
TYR FGFR3 FGFR3_HUMAN Fibroblast growth factor receptor 3 8UDTC 2.829 Inactive DFGin BLAplus in-out out-out WGF Type1.5_Front
TYR FGFR4 FGFR4_HUMAN Fibroblast growth factor receptor 4 7WCXA 2.175 Inactive DFGin BLAplus in-in out-out 90F Type1
TYR FGFR4 FGFR4_HUMAN Fibroblast growth factor receptor 4 7WCWA 2.317 Inactive DFGin BLAplus in-in out-out 90F Type1
TYR FGFR4 FGFR4_HUMAN Fibroblast growth factor receptor 4 6JPJA 2.638 Inactive DFGin BLAplus in-in out-out FGF Type1
TYR FGFR4 FGFR4_HUMAN Fibroblast growth factor receptor 4 7VJLA 2.9 Inactive DFGin BLAplus in-in none-none 7IF Type1
TYR FGFR4 FGFR4_HUMAN Fibroblast growth factor receptor 4 7VJLB 2.9 Inactive DFGin BLAplus in-in none-none 7IF Type1
TYR FGFR4 FGFR4_HUMAN Fibroblast growth factor receptor 4 6YI8A 2.13 Inactive DFGin BLAplus in-in none-out FGF Type1
TYR FGFR4 FGFR4_HUMAN Fibroblast growth factor receptor 4 6YI8B 2.13 Inactive DFGin BLAplus in-in none-out FGF Type1
TYR FGFR4 FGFR4_HUMAN Fibroblast growth factor receptor 4 7WCTA 2.106 Inactive DFGin BLAplus in-in out-out 90F Type1
TYR FGFR4 FGFR4_HUMAN Fibroblast growth factor receptor 4 5XFJA 3.25 Inactive DFGin None in-out none-out 6LF Type1
TYR FGFR4 FGFR4_HUMAN Fibroblast growth factor receptor 4 5XFFA 2.7 Inactive DFGin None in-in none-out 6LF Type1
TYR FGFR4 FGFR4_HUMAN Fibroblast growth factor receptor 4 5JKGA 2.352 Inactive DFGin None in-in none-out 6LF Type1
TYR FLT3 FLT3_HUMAN Receptor-type tyrosine-protein kinase FLT3 6JQRA 2.2 Inactive DFGout None in-in none-in C6F Type1
TYR HCK HCK_HUMAN Tyrosine-protein kinase HCK 3VS4A 2.747 Inactive DFGin BLBplus out-out out-out VSF Type1.5_Back
TYR HCK HCK_HUMAN Tyrosine-protein kinase HCK 3VS4B 2.747 Inactive DFGin BLBplus out-out out-out VSF Type1.5_Back
TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 8B9EA 1.5 Inactive DFGin None out-none out-out Q7F Type1
TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 8B9HA 1.5 Inactive DFGin None out-none out-out Q7F Type1
TYR KDR VGFR2_HUMAN Vascular endothelial growth factor receptor 2 3VO3A 1.52 Inactive DFGout None in-in out-in 0KF Type2
TYR KDR VGFR2_HUMAN Vascular endothelial growth factor receptor 2 1YWNA 1.71 Inactive None None in-in none-out LIF Type1
TYR LCK LCK_HUMAN Tyrosine-protein kinase Lck 2ZM1A 2.1 Active DFGin BLAminus in-in in-in KSF Type1
TYR MERTK MERTK_HUMAN Tyrosine-protein kinase Mer 9BHIA 2.07 Inactive DFGin BLAminus out-out in-in A1APF Type1.5_Front
TYR MERTK MERTK_HUMAN Tyrosine-protein kinase Mer 7AB1A 1.93 Inactive DFGin None out-out none-none C6F Type1
TYR MET MET_HUMAN Hepatocyte growth factor receptor 3ZCLA 1.4 Inactive DFGin BLBplus out-out out-in 5TF Type1
TYR MET MET_HUMAN Hepatocyte growth factor receptor 4MXCA 1.632 Inactive DFGout BBAminus in-in out-in DWF Type2
TYR NTRK1 NTRK1_HUMAN High affinity nerve growth factor receptor 5H3QA 2.1 Inactive DFGout BBAminus in-out out-in 7HF Type1
TYR NTRK1 NTRK1_HUMAN High affinity nerve growth factor receptor 5KMJA 2.04 Inactive DFGout None in-in out-in 6UF Type3
TYR PTK2 FAK1_HUMAN Focal adhesion kinase 1 4EBWA 2.65 Inactive DFGinter None in-in none-out 0PF Type1
TYR SYK KSYK_HUMAN Tyrosine-protein kinase SYK 5LMBA 1.95 Active DFGin BLAminus in-in in-in 6ZF Type1
TYR SYK KSYK_HUMAN Tyrosine-protein kinase SYK 5LMBB 1.95 Active DFGin BLAminus in-in in-in 6ZF Type1
TYR SYK KSYK_HUMAN Tyrosine-protein kinase SYK 4YJOA 1.6 Active DFGin BLAminus in-in in-in 4DF Type1
TYR SYK KSYK_HUMAN Tyrosine-protein kinase SYK 5TT7A 1.77 Active DFGin BLAminus in-in in-in 7KF Type1
TYR SYK KSYK_HUMAN Tyrosine-protein kinase SYK 4FYOA 1.4 Active DFGin BLAminus in-in in-in 0VF Type1
TYR SYK KSYK_HUMAN Tyrosine-protein kinase SYK 4GFGA 2.35 Active DFGin BLAminus in-in in-in 0XF Type1

Protein kinases in complex with F

Total number of genes: 64
Total number of chains: 168
Spatial Dihedral Chains Representative
DFGin BLAminus 77 4AW0A
DFGin BLAplus 17 7WCTA
DFGin ABAminus 21 7PIEA
DFGin BLBminus 4 5R9OA
DFGin BLBplus 9 3ZCLA
DFGin BLBtrans 2 2R3IA
DFGin None 16 8B9EA
DFGinter None 1 4EBWA
DFGout BBAminus 10 4MXCA
DFGout None 9 3VO3A
None None 2 5IEXA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Cricetulus griseus AGC PRKACA KAPCA_CRIGR cAMP-dependent protein kinase catalytic subunit alpha 7PIEA 1.427 Inactive DFGin ABAminus in-in in-in 7QF Type1
Gallus gallus TYR SRC SRC_CHICK Proto-oncogene tyrosine-protein kinase Src 5SYSA 2.8 Inactive DFGout BBAminus in-in none-none 72F Type2
Gallus gallus TYR SRC SRC_CHICK Proto-oncogene tyrosine-protein kinase Src 5SYSB 2.8 Inactive DFGout BBAminus in-in none-none 72F Type2
Homo sapiens AGC AKT1 AKT1_HUMAN RAC-alpha serine/threonine-protein kinase 4EKLA 2.0 Active DFGin BLAminus in-in in-in 0RF Type1
Homo sapiens AGC GRK5 GRK5_HUMAN G protein-coupled receptor kinase 5 9BREA 2.8 Active DFGin BLAminus in-in in-in W3F Type1
Homo sapiens AGC GRK5 GRK5_HUMAN G protein-coupled receptor kinase 5 8UAQA 2.8 Inactive DFGin None in-in in-in W3F Type1
Homo sapiens AGC PDPK1 PDPK1_HUMAN 3-phosphoinositide-dependent protein kinase 1 4AW0A 1.43 Active DFGin BLAminus in-in in-in ATP MJF Type1 Allosteric
Homo sapiens AGC PRKCH KPCL_HUMAN Protein kinase C eta type 8FP1A 1.85 Active DFGin BLAminus in-in in-in XXF Type1
Homo sapiens CAMK AURKA AURKA_HUMAN Aurora kinase A 8C1DA 2.115 Inactive DFGin BLAminus in-in in-out T2F ADP T5L Allosteric Type1 Allosteric
Homo sapiens CAMK AURKA AURKA_HUMAN Aurora kinase A 2W1FA 2.85 Inactive DFGin BLAminus out-out in-out L0F Type1
Homo sapiens CAMK AURKA AURKA_HUMAN Aurora kinase A 3O51A 3.2 Inactive DFGout None out-none none-none LJF Type1.5_Front
Homo sapiens CAMK CAMK2A KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha 2VZ6A 2.3 Active DFGin BLAminus in-in in-in FEF Type1
Homo sapiens CAMK CAMK2A KCC2A_HUMAN Calcium/calmodulin-dependent protein kinase type II subunit alpha 2VZ6B 2.3 Active DFGin BLAminus in-in in-in FEF Type1
Homo sapiens CAMK CHEK1 CHK1_HUMAN Serine/threonine-protein kinase Chk1 8E80A 1.49 Active DFGin BLAminus in-in in-in UUF Type1
Homo sapiens CAMK CHEK2 CHK2_HUMAN Serine/threonine-protein kinase Chk2 2YCFA 1.77 Inactive DFGin BLAminus in-out in-out YCF Type1
Homo sapiens CAMK DAPK1 DAPK1_HUMAN Death-associated protein kinase 1 6AARA 1.95 Active DFGin BLAminus in-in in-in 9TF Type1
Homo sapiens CAMK MAPKAPK2 MAPK2_HUMAN MAP kinase-activated protein kinase 2 3M42A 2.68 None DFGin BLAminus in-in in-none HGF Type1
Homo sapiens CAMK MELK MELK_HUMAN Maternal embryonic leucine zipper kinase 5IH9A 1.79 None DFGin BLAminus in-in in-none 6BF Type1
Homo sapiens CAMK PIM1 PIM1_HUMAN Serine/threonine-protein kinase pim-1 5KGIA 2.13 Active DFGin BLAminus in-in in-in 6SF Type1
Homo sapiens CAMK PIM1 PIM1_HUMAN Serine/threonine-protein kinase pim-1 6L13A 2.24 Active DFGin BLAminus in-in in-in E2F Type1
Homo sapiens CAMK PIM1 PIM1_HUMAN Serine/threonine-protein kinase pim-1 2O65A 2.85 Active DFGin BLAminus in-in in-in MYF Type1
Homo sapiens CAMK PIM1 PIM1_HUMAN Serine/threonine-protein kinase pim-1 8R0WA 1.95 Active DFGin BLAminus in-in in-in XGF Type1
Homo sapiens CAMK PIM1 PIM1_HUMAN Serine/threonine-protein kinase pim-1 8AFRA 2.15 Active DFGin BLAminus in-in in-in M0F Type1
Homo sapiens CMGC CDK12 CDK12_HUMAN Cyclin-dependent kinase 12 8BU5B 3.134 Inactive DFGin ABAminus in-out in-in RMF Type1
Homo sapiens CMGC CDK12 CDK12_HUMAN Cyclin-dependent kinase 12 8BU5H 3.134 Inactive DFGin ABAminus in-in in-in RMF Type1
Homo sapiens CMGC CDK12 CDK12_HUMAN Cyclin-dependent kinase 12 8BUNB 3.08 Inactive DFGin ABAminus in-in in-in RNF Type1
Homo sapiens CMGC CDK12 CDK12_HUMAN Cyclin-dependent kinase 12 8BUNH 3.08 Inactive DFGin ABAminus in-in in-in RNF Type1
Homo sapiens CMGC CDK12 CDK12_HUMAN Cyclin-dependent kinase 12 9FMRE 3.9 Inactive DFGin ABAminus in-out in-in RMF Type1
Homo sapiens CMGC CDK12 CDK12_HUMAN Cyclin-dependent kinase 12 9FMRH 3.9 Inactive DFGin ABAminus in-in in-in RMF Type1
Homo sapiens CMGC CDK12 CDK12_HUMAN Cyclin-dependent kinase 12 8BUNE 3.08 Active DFGin BLAminus in-in in-in RNF Type1
Homo sapiens CMGC CDK12 CDK12_HUMAN Cyclin-dependent kinase 12 8P81A 2.68 Active DFGin BLAminus in-in in-in RMF Type1
Homo sapiens CMGC CDK12 CDK12_HUMAN Cyclin-dependent kinase 12 8BU5E 3.134 Inactive DFGin None in-out in-in RMF Type1
Homo sapiens CMGC CDK12 CDK12_HUMAN Cyclin-dependent kinase 12 9FMRB 3.9 Inactive DFGin None in-out in-in RMF Type1
Homo sapiens CMGC CDK16 CDK16_HUMAN Cyclin-dependent kinase 16 3MTLA 2.4 Inactive DFGout None in-in out-none FEF Type1
Homo sapiens CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 9ESWA 2.38 Active DFGin BLAminus in-in in-in IJF IJF IJF IJF Allosteric Type1 Allosteric Allosteric
Homo sapiens CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 9ESWC 2.38 Active DFGin BLAminus in-in in-in IJF IJF IJF IJF Allosteric Type1 Allosteric Allosteric
Homo sapiens CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 9OB4A 1.95 Active DFGin BLAminus in-in in-in A1CAF Type1
Homo sapiens CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 4BCQA 2.4 Active DFGin BLAminus in-in in-in TJF Type1
Homo sapiens CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 4BCQC 2.4 Active DFGin BLAminus in-in in-in TJF Type1
Homo sapiens CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 7S9XA 1.69 Inactive DFGin BLBminus out-out out-out 8KF Type3
Homo sapiens CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 2W1HA 2.15 Inactive DFGin BLBtrans out-out out-out L0F Type1
Homo sapiens CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 2R3IA 1.28 Inactive DFGin BLBtrans out-out out-out SCF Type1
Homo sapiens CMGC CDK2 CDK2_HUMAN Cyclin-dependent kinase 2 5IEXA 2.03 Inactive None None out-out out-out 6AF Type1
Homo sapiens CMGC CDK7 CDK7_HUMAN Cyclin-dependent kinase 7 8P71J 2.0 Active DFGin BLAminus in-in in-in X4F Type1
Homo sapiens CMGC CDK8 CDK8_HUMAN Cyclin-dependent kinase 8 9H8SA 2.157 None DFGin BLAminus in-in out-none A1ITF Type1
Homo sapiens CMGC CSNK2A1 CSK21_HUMAN Casein kinase II subunit alpha 8AEMA 1.6 Active DFGin BLAminus in-in in-in LVF ATP Allosteric Type1
Homo sapiens CMGC CSNK2A1 CSK21_HUMAN Casein kinase II subunit alpha 9EPWB 2.3 Active DFGin BLAminus out-in in-in A1H6F Type1
Homo sapiens CMGC CSNK2A1 CSK21_HUMAN Casein kinase II subunit alpha 2ZJWA 2.4 Active DFGin BLAminus in-in in-in REF Type1
Homo sapiens CMGC DYRK1A DYR1A_HUMAN Dual specificity tyrosine-phosphorylation-regulated kinase 1A 6A1FA 1.5 Active DFGin BLAminus in-in in-in 9OF Type1
Homo sapiens CMGC DYRK2 DYRK2_HUMAN Dual specificity tyrosine-phosphorylation-regulated kinase 2 7DH9A 2.194 Active DFGin BLAminus in-in in-in H7F Type1
Homo sapiens CMGC GSK3B GSK3B_HUMAN Glycogen synthase kinase-3 beta 4PTEA 2.033 Active DFGin BLAminus in-in in-in 2WF Type1
Homo sapiens CMGC GSK3B GSK3B_HUMAN Glycogen synthase kinase-3 beta 4PTEB 2.033 Active DFGin BLAminus in-in in-in 2WF Type1
Homo sapiens CMGC MAPK1 MK01_HUMAN Mitogen-activated protein kinase 1 5BVDA 1.9 None DFGin BLAminus in-in in-none 4VF Type1
Homo sapiens CMGC MAPK1 MK01_HUMAN Mitogen-activated protein kinase 1 8AO6A 1.811 Active DFGin BLAminus out-in in-in N9F Type1
Homo sapiens CMGC MAPK1 MK01_HUMAN Mitogen-activated protein kinase 1 8AO9A 1.624 Inactive DFGin BLAminus out-out in-in N4F Type1
Homo sapiens CMGC MAPK10 MK10_HUMAN Mitogen-activated protein kinase 10 3CGFA 3.0 Inactive DFGin ABAminus in-out none-out JNF Type1
Homo sapiens CMGC MAPK10 MK10_HUMAN Mitogen-activated protein kinase 10 7YL1A 2.48 Inactive DFGin ABAminus in-in out-out J6F Type1
Homo sapiens CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 6ZQSA 1.95 Inactive DFGin BLAminus out-out in-in 3FF Type1
Homo sapiens CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 5XYYA 1.7 Inactive DFGin BLBminus in-in out-out P0F Type1.5_Back
Homo sapiens CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 2QD9A 1.7 Inactive DFGin BLBplus in-in none-none LGF Type1
Homo sapiens CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 3QUDA 2.0 Inactive DFGin None in-in out-out N3F Type1
Homo sapiens CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 3QUEA 2.7 Inactive DFGin None in-in out-out 3FF Type1
Homo sapiens CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 4R3CA 2.06 Inactive DFGin None in-out none-out 3GF 3GF Type1 Allosteric
Homo sapiens CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 3L8SA 2.35 Inactive DFGout None in-in none-out BFF Type1
Homo sapiens CMGC MAPK14 MK14_HUMAN Mitogen-activated protein kinase 14 3UVRA 2.1 Inactive DFGout None in-in none-out 06F Type2
Homo sapiens CMGC MAPK8 MK08_HUMAN Mitogen-activated protein kinase 8 8PTAA 2.41 Inactive DFGin ABAminus in-in out-out CIF Type1
Homo sapiens CMGC MAPK8 MK08_HUMAN Mitogen-activated protein kinase 8 8PTAB 2.41 Inactive DFGin ABAminus in-in none-out CIF Type1
Homo sapiens CMGC MAPK8 MK08_HUMAN Mitogen-activated protein kinase 8 8PTAC 2.41 Inactive DFGin ABAminus in-out out-out CIF Type1
Homo sapiens CMGC MAPK9 MK09_HUMAN Mitogen-activated protein kinase 9 3E7OA 2.14 Inactive DFGin ABAminus in-in out-out 35F Type1
Homo sapiens CMGC MAPK9 MK09_HUMAN Mitogen-activated protein kinase 9 3E7OB 2.14 Inactive DFGin ABAminus in-in none-none 35F Type1
Homo sapiens OTHER CDC7 CDC7_HUMAN Cell division cycle 7-related protein kinase 6YA8A 1.79 Active DFGin BLAminus in-in in-in ADP BEF Type1 Allosteric
Homo sapiens OTHER GAK GAK_HUMAN Cyclin-G-associated kinase 4C57A 2.55 Inactive DFGin ABAminus in-out in-in FEF Type1
Homo sapiens OTHER GAK GAK_HUMAN Cyclin-G-associated kinase 4C57B 2.55 Inactive DFGin ABAminus out-out in-in FEF Type1
Homo sapiens OTHER GAK GAK_HUMAN Cyclin-G-associated kinase 4C59A 2.8 Inactive DFGin ABAminus in-in in-none FEF Type1
Homo sapiens OTHER HASPIN HASP_HUMAN Serine/threonine-protein kinase haspin 9FLTA 2.4 Active DFGin BLAminus in-in in-none A1IDF Type1
Homo sapiens OTHER TTK TTK_HUMAN Dual specificity protein kinase TTK 4JS8A 1.94 Inactive DFGin ABAminus in-out out-out 1PF Type1
Homo sapiens OTHER TTK TTK_HUMAN Dual specificity protein kinase TTK 7CHMA 2.65 Inactive DFGin None in-in out-out FZF Type1
Homo sapiens OTHER ULK1 ULK1_HUMAN Serine/threonine-protein kinase ULK1 4WNOA 1.56 Active DFGin BLAminus in-in in-in 3RF Type1
Homo sapiens STE MAP2K1 MP2K1_HUMAN Dual specificity mitogen-activated protein kinase kinase 1 7UMBC 3.231 Inactive DFGin BLBplus out-out out-out ANP U9F Type1 Type3
Homo sapiens STE MAP2K7 MP2K7_HUMAN Dual specificity mitogen-activated protein kinase kinase 7 6YG3A 2.05 None DFGin BLAminus in-in in-none 6HF Type1
Homo sapiens STE MAP4K1 M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 8FH4A 1.827 Inactive DFGin BLAminus in-in out-out XXF Type1
Homo sapiens STE MAP4K1 M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 8FH4B 1.827 Inactive DFGin BLAminus in-in out-out XXF Type1
Homo sapiens STE MAP4K1 M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 8FH4C 1.827 Inactive DFGin BLAminus in-in out-out XXF Type1
Homo sapiens STE MAP4K1 M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 8FH4D 1.827 Inactive DFGin BLAminus in-in out-out XXF Type1
Homo sapiens STE MAP4K1 M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 9QT6A 1.76 Inactive DFGin None out-out out-out A1JAF Type1
Homo sapiens STE MAP4K1 M4K1_HUMAN Mitogen-activated protein kinase kinase kinase kinase 1 8CIJA 2.821 Inactive DFGout None out-out none-in USF Type1
Homo sapiens STE MAP4K4 M4K4_HUMAN Mitogen-activated protein kinase kinase kinase kinase 4 5DI1A 2.9 Inactive DFGin BLBplus in-out none-out 5DF Type1
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 3MTFA 2.15 Inactive DFGin BLAminus in-out in-in A3F Type1
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 3MTFB 2.15 Inactive DFGin BLAminus in-out in-in A3F Type1
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 6EIXA 2.3 Inactive DFGin BLAminus in-out in-in A3F Type1
Homo sapiens TKL ACVR1 ACVR1_HUMAN Activin receptor type-1 8PODA 2.59 Inactive DFGin BLAminus in-out in-in 7IO F Type1 Allosteric
Homo sapiens TKL BRAF BRAF_HUMAN Serine/threonine-protein kinase B-raf 4YHTA 3.05 Inactive DFGin BLAminus in-in in-out 4EF Type1
Homo sapiens TKL BRAF BRAF_HUMAN Serine/threonine-protein kinase B-raf 4YHTB 3.05 Inactive DFGin BLAminus in-in in-out 4EF Type1
Homo sapiens TKL BRAF BRAF_HUMAN Serine/threonine-protein kinase B-raf 3Q96A 3.1 Inactive DFGout BBAminus in-in none-none 0NF Type2
Homo sapiens TKL BRAF BRAF_HUMAN Serine/threonine-protein kinase B-raf 3Q96B 3.1 Inactive DFGout BBAminus in-in out-out 0NF Type2
Homo sapiens TKL IRAK4 IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 4YP8A 2.641 Active DFGin BLAminus in-in in-in 4GF Type1
Homo sapiens TKL IRAK4 IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 4YP8B 2.641 Inactive DFGin BLAminus in-out in-in 4GF Type1
Homo sapiens TKL IRAK4 IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 4YP8C 2.641 Inactive DFGin BLAminus in-out in-in 4GF Type1
Homo sapiens TKL IRAK4 IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 4YP8D 2.641 Inactive DFGin BLAminus in-out in-in 4GF Type1
Homo sapiens TKL IRAK4 IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 6LXYA 2.19 Inactive DFGin BLAminus in-out in-in EXF Type1
Homo sapiens TKL IRAK4 IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 6LXYB 2.19 None DFGin BLAminus in-none in-in EXF Type1
Homo sapiens TKL IRAK4 IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 6LXYD 2.19 Inactive DFGin BLAminus in-out in-in EXF Type1
Homo sapiens TKL IRAK4 IRAK4_HUMAN Interleukin-1 receptor-associated kinase 4 6LXYE 2.19 Inactive DFGin BLAminus in-out in-in EXF Type1
Homo sapiens TKL MAP3K12 M3K12_HUMAN Mitogen-activated protein kinase kinase kinase 12 5CEQA 1.911 Inactive DFGin BLBplus out-out none-out 50F Type1
Homo sapiens TKL MAP3K7 M3K7_HUMAN Mitogen-activated protein kinase kinase kinase 7 5J9LA 2.752 Inactive DFGout None in-out none-out 6HF Type1
Homo sapiens TKL RIPK1 RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 7FCZA 2.21 Inactive DFGout BBAminus out-out out-out 3IF Type3
Homo sapiens TKL RIPK1 RIPK1_HUMAN Receptor-interacting serine/threonine-protein kinase 1 7FCZB 2.21 Inactive DFGout BBAminus out-out out-out 3IF Type3
Homo sapiens TKL TGFBR1 TGFR1_HUMAN TGF-beta receptor type-1 2WOUA 2.3 Active DFGin BLAminus in-in in-in ZZF Type1
Homo sapiens TKL TGFBR1 TGFR1_HUMAN TGF-beta receptor type-1 3FAAA 3.35 Active DFGin BLAminus in-in in-in 55F Type1
Homo sapiens TKL TGFBR1 TGFR1_HUMAN TGF-beta receptor type-1 3FAAB 3.35 Active DFGin BLAminus in-in in-in 55F Type1
Homo sapiens TKL TGFBR1 TGFR1_HUMAN TGF-beta receptor type-1 3FAAC 3.35 Active DFGin BLAminus in-in in-in 55F Type1
Homo sapiens TKL TGFBR1 TGFR1_HUMAN TGF-beta receptor type-1 3FAAD 3.35 Active DFGin BLAminus in-in in-in 55F Type1
Homo sapiens TKL TGFBR1 TGFR1_HUMAN TGF-beta receptor type-1 3FAAE 3.35 Active DFGin BLAminus in-in in-in 55F Type1
Homo sapiens TKL TGFBR2 TGFR2_HUMAN TGF-beta receptor type-2 7DV6A 2.39 Active DFGin BLAminus in-in in-in HJF Type1
Homo sapiens TYR ALK ALK_HUMAN ALK tyrosine kinase receptor 4CCUA 2.0 Inactive DFGin ABAminus in-out out-in AWF Type1
Homo sapiens TYR ALK ALK_HUMAN ALK tyrosine kinase receptor 4FNZA 2.6 Inactive DFGin ABAminus in-in none-in NZF Type1
Homo sapiens TYR ALK ALK_HUMAN ALK tyrosine kinase receptor 4DCEA 2.03 Inactive DFGin None in-in none-in 0JF Type1
Homo sapiens TYR ALK ALK_HUMAN ALK tyrosine kinase receptor 4DCEB 2.03 Inactive DFGin None in-in none-out 0JF Type1
Homo sapiens TYR BTK BTK_HUMAN Tyrosine-protein kinase BTK 5FBNC 1.8 Inactive DFGin BLBplus out-out out-out 5WF 5WE Type1.5_Front Allosteric
Homo sapiens TYR BTK BTK_HUMAN Tyrosine-protein kinase BTK 5FBND 1.8 Inactive DFGin BLBplus out-out out-in 5WF 5WE 5WE 5WE Type1.5_Front Allosteric Allosteric Allosteric
Homo sapiens TYR DDR1 DDR1_HUMAN Epithelial discoidin domain-containing receptor 1 5SAUA 1.8 Inactive DFGout BBAminus in-in out-in 1IF Type2
Homo sapiens TYR EPHA2 EPHA2_HUMAN Ephrin type-A receptor 2 8BOCA 1.9 Inactive DFGout BBAminus in-in out-in QUF Type2
Homo sapiens TYR EPHB4 EPHB4_HUMAN Ephrin type-B receptor 4 2X9FA 1.75 Inactive DFGin BLBminus in-in out-in X9F Type1
Homo sapiens TYR FGFR1 FGFR1_HUMAN Fibroblast growth factor receptor 1 3C4FA 2.07 Inactive DFGin BLAplus in-out out-out C4F Type1.5_Back
Homo sapiens TYR FGFR1 FGFR1_HUMAN Fibroblast growth factor receptor 1 3C4FB 2.07 Inactive DFGin BLAplus in-in out-out C4F Type1.5_Back
Homo sapiens TYR FGFR1 FGFR1_HUMAN Fibroblast growth factor receptor 1 5EW8A 1.63 Inactive DFGin BLAplus in-in out-out 5SF Type1.5_Back
Homo sapiens TYR FGFR1 FGFR1_HUMAN Fibroblast growth factor receptor 1 5EW8B 1.63 Inactive DFGin BLAplus in-in out-out 5SF Type1.5_Back
Homo sapiens TYR FGFR1 FGFR1_HUMAN Fibroblast growth factor receptor 1 7WCLA 2.495 Inactive DFGin BLAplus in-in out-out 8ZF Type1.5_Back
Homo sapiens TYR FGFR1 FGFR1_HUMAN Fibroblast growth factor receptor 1 7WCLB 2.495 Inactive DFGin BLAplus in-in none-out 8ZF Type1.5_Back
Homo sapiens TYR FGFR3 FGFR3_HUMAN Fibroblast growth factor receptor 3 8UDTA 2.829 Inactive DFGin BLAplus in-out out-out MLT MLT WGF Allosteric Allosteric Type1.5_Front
Homo sapiens TYR FGFR3 FGFR3_HUMAN Fibroblast growth factor receptor 3 8UDTB 2.829 Inactive DFGin BLAplus in-out out-out WGF Type1.5_Front
Homo sapiens TYR FGFR3 FGFR3_HUMAN Fibroblast growth factor receptor 3 8UDTC 2.829 Inactive DFGin BLAplus in-out out-out WGF Type1.5_Front
Homo sapiens TYR FGFR4 FGFR4_HUMAN Fibroblast growth factor receptor 4 7WCXA 2.175 Inactive DFGin BLAplus in-in out-out 90F Type1
Homo sapiens TYR FGFR4 FGFR4_HUMAN Fibroblast growth factor receptor 4 7WCWA 2.317 Inactive DFGin BLAplus in-in out-out 90F Type1
Homo sapiens TYR FGFR4 FGFR4_HUMAN Fibroblast growth factor receptor 4 6JPJA 2.638 Inactive DFGin BLAplus in-in out-out FGF Type1
Homo sapiens TYR FGFR4 FGFR4_HUMAN Fibroblast growth factor receptor 4 7VJLA 2.9 Inactive DFGin BLAplus in-in none-none 7IF Type1
Homo sapiens TYR FGFR4 FGFR4_HUMAN Fibroblast growth factor receptor 4 7VJLB 2.9 Inactive DFGin BLAplus in-in none-none 7IF Type1
Homo sapiens TYR FGFR4 FGFR4_HUMAN Fibroblast growth factor receptor 4 6YI8A 2.13 Inactive DFGin BLAplus in-in none-out FGF Type1
Homo sapiens TYR FGFR4 FGFR4_HUMAN Fibroblast growth factor receptor 4 6YI8B 2.13 Inactive DFGin BLAplus in-in none-out FGF Type1
Homo sapiens TYR FGFR4 FGFR4_HUMAN Fibroblast growth factor receptor 4 7WCTA 2.106 Inactive DFGin BLAplus in-in out-out 90F Type1
Homo sapiens TYR FGFR4 FGFR4_HUMAN Fibroblast growth factor receptor 4 5XFJA 3.25 Inactive DFGin None in-out none-out 6LF Type1
Homo sapiens TYR FGFR4 FGFR4_HUMAN Fibroblast growth factor receptor 4 5XFFA 2.7 Inactive DFGin None in-in none-out 6LF Type1
Homo sapiens TYR FGFR4 FGFR4_HUMAN Fibroblast growth factor receptor 4 5JKGA 2.352 Inactive DFGin None in-in none-out 6LF Type1
Homo sapiens TYR FLT3 FLT3_HUMAN Receptor-type tyrosine-protein kinase FLT3 6JQRA 2.2 Inactive DFGout None in-in none-in C6F Type1
Homo sapiens TYR HCK HCK_HUMAN Tyrosine-protein kinase HCK 3VS4A 2.747 Inactive DFGin BLBplus out-out out-out VSF Type1.5_Back
Homo sapiens TYR HCK HCK_HUMAN Tyrosine-protein kinase HCK 3VS4B 2.747 Inactive DFGin BLBplus out-out out-out VSF Type1.5_Back
Homo sapiens TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 8B9EA 1.5 Inactive DFGin None out-none out-out Q7F Type1
Homo sapiens TYR JAK2 JAK2_HUMAN Tyrosine-protein kinase JAK2 8B9HA 1.5 Inactive DFGin None out-none out-out Q7F Type1
Homo sapiens TYR KDR VGFR2_HUMAN Vascular endothelial growth factor receptor 2 3VO3A 1.52 Inactive DFGout None in-in out-in 0KF Type2
Homo sapiens TYR KDR VGFR2_HUMAN Vascular endothelial growth factor receptor 2 1YWNA 1.71 Inactive None None in-in none-out LIF Type1
Homo sapiens TYR LCK LCK_HUMAN Tyrosine-protein kinase Lck 2ZM1A 2.1 Active DFGin BLAminus in-in in-in KSF Type1
Homo sapiens TYR MERTK MERTK_HUMAN Tyrosine-protein kinase Mer 9BHIA 2.07 Inactive DFGin BLAminus out-out in-in A1APF Type1.5_Front
Homo sapiens TYR MERTK MERTK_HUMAN Tyrosine-protein kinase Mer 7AB1A 1.93 Inactive DFGin None out-out none-none C6F Type1
Homo sapiens TYR MET MET_HUMAN Hepatocyte growth factor receptor 3ZCLA 1.4 Inactive DFGin BLBplus out-out out-in 5TF Type1
Homo sapiens TYR MET MET_HUMAN Hepatocyte growth factor receptor 4MXCA 1.632 Inactive DFGout BBAminus in-in out-in DWF Type2
Homo sapiens TYR NTRK1 NTRK1_HUMAN High affinity nerve growth factor receptor 5H3QA 2.1 Inactive DFGout BBAminus in-out out-in 7HF Type1
Homo sapiens TYR NTRK1 NTRK1_HUMAN High affinity nerve growth factor receptor 5KMJA 2.04 Inactive DFGout None in-in out-in 6UF Type3
Homo sapiens TYR PTK2 FAK1_HUMAN Focal adhesion kinase 1 4EBWA 2.65 Inactive DFGinter None in-in none-out 0PF Type1
Homo sapiens TYR SYK KSYK_HUMAN Tyrosine-protein kinase SYK 5LMBA 1.95 Active DFGin BLAminus in-in in-in 6ZF Type1
Homo sapiens TYR SYK KSYK_HUMAN Tyrosine-protein kinase SYK 5LMBB 1.95 Active DFGin BLAminus in-in in-in 6ZF Type1
Homo sapiens TYR SYK KSYK_HUMAN Tyrosine-protein kinase SYK 4YJOA 1.6 Active DFGin BLAminus in-in in-in 4DF Type1
Homo sapiens TYR SYK KSYK_HUMAN Tyrosine-protein kinase SYK 5TT7A 1.77 Active DFGin BLAminus in-in in-in 7KF Type1
Homo sapiens TYR SYK KSYK_HUMAN Tyrosine-protein kinase SYK 4FYOA 1.4 Active DFGin BLAminus in-in in-in 0VF Type1
Homo sapiens TYR SYK KSYK_HUMAN Tyrosine-protein kinase SYK 4GFGA 2.35 Active DFGin BLAminus in-in in-in 0XF Type1
Mus musculus CMGC MAPK14 MK14_MOUSE Mitogen-activated protein kinase 14 5R9OA 1.6 Inactive DFGin BLBminus in-in out-out 54F Allosteric
Mus musculus TKL RIPK3 RIPK3_MOUSE Receptor-interacting serine/threonine-protein kinase 3 9LVHA 2.38 None DFGin BLAminus in-in in-none MYF Type1
Mus musculus TKL RIPK3 RIPK3_MOUSE Receptor-interacting serine/threonine-protein kinase 3 9LVHB 2.38 None DFGin BLAminus in-in in-none MYF Type1
Saccharomyces cerevisiae OTHER CDC7 CDC7_YEAST Cell division control protein 7 7PT78 3.8 Inactive DFGin ABAminus in-out in-in ADP BEF Type1 Allosteric

Protein kinases in complex with F

Total number of genes: 5
Total number of chains: 7
Spatial Dihedral Chains Representative
DFGin BLAminus 2 9LVHB
DFGin ABAminus 2 7PIEA
DFGin BLBminus 1 5R9OA
DFGout BBAminus 2 5SYSA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Cricetulus griseus AGC PRKACA KAPCA_CRIGR cAMP-dependent protein kinase catalytic subunit alpha 7PIEA 1.427 Inactive DFGin ABAminus in-in in-in 7QF Type1
Gallus gallus TYR SRC SRC_CHICK Proto-oncogene tyrosine-protein kinase Src 5SYSA 2.8 Inactive DFGout BBAminus in-in none-none 72F Type2
Gallus gallus TYR SRC SRC_CHICK Proto-oncogene tyrosine-protein kinase Src 5SYSB 2.8 Inactive DFGout BBAminus in-in none-none 72F Type2
Mus musculus CMGC MAPK14 MK14_MOUSE Mitogen-activated protein kinase 14 5R9OA 1.6 Inactive DFGin BLBminus in-in out-out 54F Allosteric
Mus musculus TKL RIPK3 RIPK3_MOUSE Receptor-interacting serine/threonine-protein kinase 3 9LVHA 2.38 None DFGin BLAminus in-in in-none MYF Type1
Mus musculus TKL RIPK3 RIPK3_MOUSE Receptor-interacting serine/threonine-protein kinase 3 9LVHB 2.38 None DFGin BLAminus in-in in-none MYF Type1
Saccharomyces cerevisiae OTHER CDC7 CDC7_YEAST Cell division control protein 7 7PT78 3.8 Inactive DFGin ABAminus in-out in-in ADP BEF Type1 Allosteric