MARK3 (MAP/microtubule affinity-regulating kinase 3)

Group: CAMK
Uniprot: MARK3_HUMAN
Domain boundary: 56 - 307


Total number of chains: 15
Spatial Dihedral Chains Representative
DFGin BLAminus 4 AF-P27448-K1A
DFGin BLBminus 1 7P1LA
DFGin BLBtrans 1 8UOJA
None None 9 3FE3A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-P27448-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 48 - 315 None None 0
8UOIA 1.8 Inactive DFGin BLAminus in-out in-in X3Q Type1 51 - 368 I62L,L72R,V116I,G137K,F141Y,A146E,V205K None 5
8UOKA 1.85 Active DFGin BLAminus in-in in-in X5N Type1 51 - 369 I62L,L72R,V116I,G137K,F141Y,A146E,V205K None 0
8UOKB 1.85 Active DFGin BLAminus in-in in-in X5N Type1 51 - 369 I62L,L72R,V116I,G137K,F141Y,A146E,V205K None 0
7P1LA 1.95 Inactive DFGin BLBminus out-out out-none V5E Type1 50 - 365 None None 9
8UOJA 1.6 Inactive DFGin BLBtrans out-out out-in X5I BEZ Type1 Allosteric 50 - 370 I62L,L72R,V116I,G137K,F141Y,A146E None 0
2QNJA 2.7 Inactive None None in-out out-out No_ligand No_ligand 44 - 366 None None 5
2QNJB 2.7 Inactive None None out-out out-out No_ligand No_ligand 44 - 367 None None 3
3FE3A 1.9 Inactive None None out-out out-out No_ligand No_ligand 50 - 366 T211A,S215A None 0
3FE3B 1.9 Inactive None None out-out out-out No_ligand No_ligand 50 - 366 T211A,S215A None 0
8UOHA 2.15 Inactive None None out-out out-out No_ligand No_ligand 48 - 369 I62L,L72R,V116I,G137K,F141Y,A146E None 0
7P1LB 1.95 Inactive None None out-out out-none V5E Type1 50 - 365 None None 9
8UOHB 2.15 Inactive None None in-out out-out X4W Type1 48 - 370 I62L,L72R,V116I,G137K,F141Y,A146E None 0
8UOLA 1.9 Inactive None None out-out out-none X4H Type1 51 - 370 I62L,L72R,V116I,G137K,F141Y,A146E None 8
8UOLB 1.9 Inactive None None out-out out-in X4H Type1 50 - 367 I62L,L72R,V116I,G137K,F141Y,A146E None 8

MARK3 (MAP/microtubule affinity-regulating kinase 3)

Group: CAMK
Total number of chains: 15
Spatial Dihedral Chains Representative
DFGin BLAminus 4 AF-P27448-K1A
DFGin BLBminus 1 7P1LA
DFGin BLBtrans 1 8UOJA
None None 9 3FE3A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens MARK3_HUMAN AF-P27448-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 48 - 315 None None 0
Homo sapiens MARK3_HUMAN 8UOIA 1.8 Inactive DFGin BLAminus in-out in-in X3Q Type1 51 - 368 I62L,L72R,V116I,G137K,F141Y,A146E,V205K None 5
Homo sapiens MARK3_HUMAN 8UOKA 1.85 Active DFGin BLAminus in-in in-in X5N Type1 51 - 369 I62L,L72R,V116I,G137K,F141Y,A146E,V205K None 0
Homo sapiens MARK3_HUMAN 8UOKB 1.85 Active DFGin BLAminus in-in in-in X5N Type1 51 - 369 I62L,L72R,V116I,G137K,F141Y,A146E,V205K None 0
Homo sapiens MARK3_HUMAN 7P1LA 1.95 Inactive DFGin BLBminus out-out out-none V5E Type1 50 - 365 None None 9
Homo sapiens MARK3_HUMAN 8UOJA 1.6 Inactive DFGin BLBtrans out-out out-in X5I BEZ Type1 Allosteric 50 - 370 I62L,L72R,V116I,G137K,F141Y,A146E None 0
Homo sapiens MARK3_HUMAN 2QNJA 2.7 Inactive None None in-out out-out No_ligand No_ligand 44 - 366 None None 5
Homo sapiens MARK3_HUMAN 2QNJB 2.7 Inactive None None out-out out-out No_ligand No_ligand 44 - 367 None None 3
Homo sapiens MARK3_HUMAN 3FE3A 1.9 Inactive None None out-out out-out No_ligand No_ligand 50 - 366 T211A,S215A None 0
Homo sapiens MARK3_HUMAN 3FE3B 1.9 Inactive None None out-out out-out No_ligand No_ligand 50 - 366 T211A,S215A None 0
Homo sapiens MARK3_HUMAN 8UOHA 2.15 Inactive None None out-out out-out No_ligand No_ligand 48 - 369 I62L,L72R,V116I,G137K,F141Y,A146E None 0
Homo sapiens MARK3_HUMAN 7P1LB 1.95 Inactive None None out-out out-none V5E Type1 50 - 365 None None 9
Homo sapiens MARK3_HUMAN 8UOHB 2.15 Inactive None None in-out out-out X4W Type1 48 - 370 I62L,L72R,V116I,G137K,F141Y,A146E None 0
Homo sapiens MARK3_HUMAN 8UOLA 1.9 Inactive None None out-out out-none X4H Type1 51 - 370 I62L,L72R,V116I,G137K,F141Y,A146E None 8
Homo sapiens MARK3_HUMAN 8UOLB 1.9 Inactive None None out-out out-in X4H Type1 50 - 367 I62L,L72R,V116I,G137K,F141Y,A146E None 8

MARK3 (MAP/microtubule affinity-regulating kinase 3)

No non-human structures known.