ULK1 (Serine/threonine-protein kinase ULK1)

Group: OTHER
Uniprot: ULK1_HUMAN
Domain boundary: 14 - 278


Total number of chains: 29
Spatial Dihedral Chains Representative
DFGin BLAminus 28 AF-O75385-K1A
None None 1 9F32A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-O75385-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 6 - 286 None None 0
8P5GA 2.019 Active DFGin BLAminus in-in in-in XBJ Type1 8 - 280 None X180 0
8P5GB 2.019 Active DFGin BLAminus in-in in-in XBJ Type1 8 - 279 None X180 0
8P5HA 1.941 Active DFGin BLAminus in-in in-in XBJ Type1 8 - 280 R245A,E246A X180 0
8P5HB 1.941 Active DFGin BLAminus in-in in-in XBJ Type1 8 - 280 R245A,E246A X180 0
8P5IA 1.829 Active DFGin BLAminus in-in in-in WYX Type1 8 - 280 R245A,E246A X180 0
8P5IB 1.829 Active DFGin BLAminus in-in in-in WYX Type1 8 - 280 R245A,E246A X180 0
8P5IC 1.829 Active DFGin BLAminus in-in in-in WYX Type1 8 - 280 R245A,E246A X180 0
8P5ID 1.829 Active DFGin BLAminus in-in in-in WYX Type1 8 - 279 R245A,E246A X180 0
8P5JA 2.164 Active DFGin BLAminus in-in in-in WYT Type1 8 - 279 R245A,E246A X180 0
8P5JB 2.164 Active DFGin BLAminus in-in in-in WYT Type1 8 - 279 R245A,E246A X180 0
8P5KA 2.209 Active DFGin BLAminus in-in in-in HVH Type1 8 - 280 R245A,E246A X180 0
8P5KB 2.209 Active DFGin BLAminus in-in in-in HVH Type1 8 - 280 R245A,E246A X180 0
8P5KC 2.209 Active DFGin BLAminus in-in in-in HVH Type1 8 - 279 R245A,E246A X180 0
8P5KD 2.209 Active DFGin BLAminus in-in in-in HVH Type1 8 - 280 R245A,E246A X180 0
8P5LA 1.836 Active DFGin BLAminus in-in in-in 1FV Type1 8 - 280 R245A,E246A X180 0
8P5LB 1.836 Active DFGin BLAminus in-in in-in 1FV Type1 8 - 280 R245A,E246A X180 0
6MNHA 1.73 Inactive DFGin BLAminus in-in in-out JVD Type1 8 - 290 S195A,S224A X87 7
8SV9A 2.3 Active DFGin BLAminus in-in in-in WXH Type1 8 - 281 E37A,K38A X87,X180 0
8SV9B 2.3 Active DFGin BLAminus in-in in-in WXH Type1 8 - 281 E37A,K38A X87,X180 0
4WNOA 1.56 Active DFGin BLAminus in-in in-in 3RF Type1 8 - 280 E37A,K38A X180 0
4WNPA 1.88 Active DFGin BLAminus in-in in-in 3RJ Type1 7 - 280 E37A,K38A X180 0
4WNPB 1.88 Active DFGin BLAminus in-in in-in 3RJ Type1 8 - 280 E37A,K38A X180 0
4WNPC 1.88 Active DFGin BLAminus in-in in-in 3RJ Type1 8 - 279 E37A,K38A X180 0
4WNPD 1.88 Active DFGin BLAminus in-in in-in 3RJ Type1 8 - 280 E37A,K38A X180 0
5CI7A 1.74 Active DFGin BLAminus in-in in-in 51W Type1 3 - 279 E37A,K38A X180 0
6QASA 1.75 Active DFGin BLAminus in-in in-in 34W Type1 8 - 281 None X87,X180 0
6QASB 1.75 Active DFGin BLAminus in-in in-in 34W 34W Type1 Allosteric 8 - 280 None X87,X180 0
9F32A 2.1 Inactive None None none-none none-out A1H9M Type1 8 - 282 None None 15

ULK1 (Serine/threonine-protein kinase ULK1)

Group: OTHER
Total number of chains: 29
Spatial Dihedral Chains Representative
DFGin BLAminus 28 AF-O75385-K1A
None None 1 9F32A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens ULK1_HUMAN AF-O75385-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 6 - 286 None None 0
Homo sapiens ULK1_HUMAN 8P5GA 2.019 Active DFGin BLAminus in-in in-in XBJ Type1 8 - 280 None X180 0
Homo sapiens ULK1_HUMAN 8P5GB 2.019 Active DFGin BLAminus in-in in-in XBJ Type1 8 - 279 None X180 0
Homo sapiens ULK1_HUMAN 8P5HA 1.941 Active DFGin BLAminus in-in in-in XBJ Type1 8 - 280 R245A,E246A X180 0
Homo sapiens ULK1_HUMAN 8P5HB 1.941 Active DFGin BLAminus in-in in-in XBJ Type1 8 - 280 R245A,E246A X180 0
Homo sapiens ULK1_HUMAN 8P5IA 1.829 Active DFGin BLAminus in-in in-in WYX Type1 8 - 280 R245A,E246A X180 0
Homo sapiens ULK1_HUMAN 8P5IB 1.829 Active DFGin BLAminus in-in in-in WYX Type1 8 - 280 R245A,E246A X180 0
Homo sapiens ULK1_HUMAN 8P5IC 1.829 Active DFGin BLAminus in-in in-in WYX Type1 8 - 280 R245A,E246A X180 0
Homo sapiens ULK1_HUMAN 8P5ID 1.829 Active DFGin BLAminus in-in in-in WYX Type1 8 - 279 R245A,E246A X180 0
Homo sapiens ULK1_HUMAN 8P5JA 2.164 Active DFGin BLAminus in-in in-in WYT Type1 8 - 279 R245A,E246A X180 0
Homo sapiens ULK1_HUMAN 8P5JB 2.164 Active DFGin BLAminus in-in in-in WYT Type1 8 - 279 R245A,E246A X180 0
Homo sapiens ULK1_HUMAN 8P5KA 2.209 Active DFGin BLAminus in-in in-in HVH Type1 8 - 280 R245A,E246A X180 0
Homo sapiens ULK1_HUMAN 8P5KB 2.209 Active DFGin BLAminus in-in in-in HVH Type1 8 - 280 R245A,E246A X180 0
Homo sapiens ULK1_HUMAN 8P5KC 2.209 Active DFGin BLAminus in-in in-in HVH Type1 8 - 279 R245A,E246A X180 0
Homo sapiens ULK1_HUMAN 8P5KD 2.209 Active DFGin BLAminus in-in in-in HVH Type1 8 - 280 R245A,E246A X180 0
Homo sapiens ULK1_HUMAN 8P5LA 1.836 Active DFGin BLAminus in-in in-in 1FV Type1 8 - 280 R245A,E246A X180 0
Homo sapiens ULK1_HUMAN 8P5LB 1.836 Active DFGin BLAminus in-in in-in 1FV Type1 8 - 280 R245A,E246A X180 0
Homo sapiens ULK1_HUMAN 6MNHA 1.73 Inactive DFGin BLAminus in-in in-out JVD Type1 8 - 290 S195A,S224A X87 7
Homo sapiens ULK1_HUMAN 8SV9A 2.3 Active DFGin BLAminus in-in in-in WXH Type1 8 - 281 E37A,K38A X87,X180 0
Homo sapiens ULK1_HUMAN 8SV9B 2.3 Active DFGin BLAminus in-in in-in WXH Type1 8 - 281 E37A,K38A X87,X180 0
Homo sapiens ULK1_HUMAN 4WNOA 1.56 Active DFGin BLAminus in-in in-in 3RF Type1 8 - 280 E37A,K38A X180 0
Homo sapiens ULK1_HUMAN 4WNPA 1.88 Active DFGin BLAminus in-in in-in 3RJ Type1 7 - 280 E37A,K38A X180 0
Homo sapiens ULK1_HUMAN 4WNPB 1.88 Active DFGin BLAminus in-in in-in 3RJ Type1 8 - 280 E37A,K38A X180 0
Homo sapiens ULK1_HUMAN 4WNPC 1.88 Active DFGin BLAminus in-in in-in 3RJ Type1 8 - 279 E37A,K38A X180 0
Homo sapiens ULK1_HUMAN 4WNPD 1.88 Active DFGin BLAminus in-in in-in 3RJ Type1 8 - 280 E37A,K38A X180 0
Homo sapiens ULK1_HUMAN 5CI7A 1.74 Active DFGin BLAminus in-in in-in 51W Type1 3 - 279 E37A,K38A X180 0
Homo sapiens ULK1_HUMAN 6QASA 1.75 Active DFGin BLAminus in-in in-in 34W Type1 8 - 281 None X87,X180 0
Homo sapiens ULK1_HUMAN 6QASB 1.75 Active DFGin BLAminus in-in in-in 34W 34W Type1 Allosteric 8 - 280 None X87,X180 0
Homo sapiens ULK1_HUMAN 9F32A 2.1 Inactive None None none-none none-out A1H9M Type1 8 - 282 None None 15

ULK1 (Serine/threonine-protein kinase ULK1)

No non-human structures known.