CMGC_CDK8 (Cyclin-dependent kinase 8)

Total number of chains: 38
Active chains: 2
Uniprot: CDK8_HUMAN
Kinase Domain Residues: 20 - 335
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 14 36.8% 6T41A
DFGin BLAminus 10 26.3% AF-P49336-K1A
DFGout BBAminus 9 23.7% 6TPAA
DFGin BLAplus 3 7.9% 8TQ2A
DFGin BLBplus 1 2.6% 5HBHA
None None 1 2.6% 4F70A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-P49336-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 12 - 343 0 None None Cyclin-dependent kinase 8
AF-P49336-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 12 - 343 0 None None Cyclin-dependent kinase 8
5HBJA 3.0 Inactive DFGin‑BLAminus in-in none-out nonTYR APEdihe_aaiii APEdist_nnno 5Y8 Type1 1 - 361 0 None None Cyclin-dependent kinase 8
5ICPA 2.18 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnoo 69Z Type1 1 - 362 0 None None Cyclin-dependent kinase 8
5IDNA 2.26 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno 6A7 Type1 1 - 363 0 None None Cyclin-dependent kinase 8
5XQXA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnno 8CC Type1 1 - 362 0 None None Cyclin-dependent kinase 8
5XS2A 2.04 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo 8D6 Type1 1 - 363 0 None None Cyclin-dependent kinase 8
6QTJA 2.48 Inactive DFGin‑BLAminus in-in none-out nonTYR APEdihe_aaiii APEdist_nnno JHK Type1 1 - 359 0 None None Cyclin-dependent kinase 8
9H8CA 2.573 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaiii APEdist_nnno A1IS8 Type1 1 - 361 0 None None Cyclin-dependent kinase 8
9H8SA 2.157 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn A1ITF Type1 1 - 362 0 None None Cyclin-dependent kinase 8
8TQ2A 3.8 Inactive DFGin‑BLAplus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 1 - 359 0 None None Cyclin-dependent kinase 8
8TQCA 3.8 Inactive DFGin‑BLAplus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 1 - 359 0 None None Cyclin-dependent kinase 8
8TQWA 8.2 Inactive DFGin‑BLAplus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 1 - 359 0 None None Cyclin-dependent kinase 8
4G6LA 2.7 Inactive DFGin‑BLBminus in-in out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 1 - 359 0 None None Cyclin-dependent kinase 8
5FGKA 2.36 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaiii APEdist_nnno 5XG Type1 1 - 362 0 None None Cyclin-dependent kinase 8
5HBEA 2.38 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno 5Y6 Type1 1 - 361 0 None None Cyclin-dependent kinase 8
5HNBA 2.35 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aanio APEdist_nnnn 62M Type1 1 - 359 0 None None Cyclin-dependent kinase 8
5I5ZA 2.6 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn 68U Type1 1 - 362 0 None None Cyclin-dependent kinase 8
5IDPA 2.65 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn 6A6 Type1 1 - 359 0 None None Cyclin-dependent kinase 8
4F7SA 2.2 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn 0SW Type1 1 - 359 0 None None Cyclin-dependent kinase 8
5BNJA 2.64 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn 4TV Type1 1 - 362 0 None None Cyclin-dependent kinase 8
6QTGA 2.7 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaiii APEdist_nnno JH8 Type1 1 - 359 0 None None Cyclin-dependent kinase 8
4CRLA 2.4 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno C1I Type1 1 - 359 0 None None Cyclin-dependent kinase 8
5CEIA 2.24 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn 50R Type1 1 - 362 0 None None Cyclin-dependent kinase 8
6R3SA 2.19 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn JRE Type1 1 - 362 0 None None Cyclin-dependent kinase 8
6Y0AA 2.19 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn JRE Type1 1 - 362 0 None None Cyclin-dependent kinase 8
6T41A 2.45 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn MFE Type1 1 - 359 0 None None Cyclin-dependent kinase 8
5HBHA 2.5 Inactive DFGin‑BLBplus in-in out-out nonTYR APEdihe_aaioi APEdist_nnoo 5Y7 Type1 1 - 361 0 None None Cyclin-dependent kinase 8
3RGFA 2.2 Inactive DFGout‑BBAminus in-out out-out nonTYR APEdihe_aaioi APEdist_nnno BAX Type2 1 - 353 0 None None Cyclin-dependent kinase 8
4F6UA 2.1 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaioi APEdist_nnio 0SR Type2 1 - 359 0 None None Cyclin-dependent kinase 8
4F6WA 2.39 Inactive DFGout‑BBAminus in-in none-none nonTYR APEdihe_aanii APEdist_nnnn 0SS Type2 1 - 359 0 None None Cyclin-dependent kinase 8
4F7LA 2.9 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn 0SO Type2 1 - 359 0 None None Cyclin-dependent kinase 8
4F7NA 2.65 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaioi APEdist_nnio 0SV Type2 1 - 361 0 None None Cyclin-dependent kinase 8
5HVYA 2.39 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oioo 66X Type2 1 - 359 0 None None Cyclin-dependent kinase 8
6TPAA 2.8 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn NZ8, NZ5, NZ5, NZ5 Type2, Allosteric, Allosteric, Allosteric 1 - 359 0 None None Cyclin-dependent kinase 8
4F6SA 2.6 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 0SQ Type3 1 - 359 0 None None Cyclin-dependent kinase 8
4F7JA 2.6 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaiii APEdist_nnno 0SU Type3 1 - 359 0 None None Cyclin-dependent kinase 8
4F70A 3.0 Inactive None‑None in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 0ST Type3 1 - 359 0 None None Cyclin-dependent kinase 8

CMGC_CDK8 (Cyclin-dependent kinase 8)

Total number of chains: 38
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBminus 14 36.8% 6T41A
DFGin BLAminus 10 26.3% AF-P49336-K1A
DFGout BBAminus 9 23.7% 6TPAA
DFGin BLAplus 3 7.9% 8TQ2A
DFGin BLBplus 1 2.6% 5HBHA
None None 1 2.6% 4F70A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CDK8_HUMAN AF-P49336-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 12 - 343 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN AF-P49336-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 12 - 343 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 5HBJA 3.0 Inactive DFGin‑BLAminus in-in none-out nonTYR APEdihe_aaiii APEdist_nnno 5Y8 Type1 1 - 361 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 5ICPA 2.18 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnoo 69Z Type1 1 - 362 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 5IDNA 2.26 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno 6A7 Type1 1 - 363 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 5XQXA 2.3 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nnno 8CC Type1 1 - 362 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 5XS2A 2.04 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaioi APEdist_iioo 8D6 Type1 1 - 363 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 6QTJA 2.48 Inactive DFGin‑BLAminus in-in none-out nonTYR APEdihe_aaiii APEdist_nnno JHK Type1 1 - 359 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 9H8CA 2.573 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aaiii APEdist_nnno A1IS8 Type1 1 - 361 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 9H8SA 2.157 Inactive DFGin‑BLAminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn A1ITF Type1 1 - 362 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 8TQ2A 3.8 Inactive DFGin‑BLAplus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 1 - 359 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 8TQCA 3.8 Inactive DFGin‑BLAplus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 1 - 359 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 8TQWA 8.2 Inactive DFGin‑BLAplus in-out in-out nonTYR APEdihe_aaioi APEdist_iiii No_ligand No_ligand 1 - 359 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 4G6LA 2.7 Inactive DFGin‑BLBminus in-in out-none nonTYR APEdihe_aannn APEdist_nnnn No_ligand No_ligand 1 - 359 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 5FGKA 2.36 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaiii APEdist_nnno 5XG Type1 1 - 362 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 5HBEA 2.38 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno 5Y6 Type1 1 - 361 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 5HNBA 2.35 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aanio APEdist_nnnn 62M Type1 1 - 359 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 5I5ZA 2.6 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn 68U Type1 1 - 362 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 5IDPA 2.65 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn 6A6 Type1 1 - 359 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 4F7SA 2.2 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn 0SW Type1 1 - 359 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 5BNJA 2.64 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn 4TV Type1 1 - 362 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 6QTGA 2.7 Inactive DFGin‑BLBminus in-in none-out nonTYR APEdihe_aaiii APEdist_nnno JH8 Type1 1 - 359 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 4CRLA 2.4 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aaioi APEdist_nnno C1I Type1 1 - 359 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 5CEIA 2.24 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn 50R Type1 1 - 362 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 6R3SA 2.19 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn JRE Type1 1 - 362 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 6Y0AA 2.19 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn JRE Type1 1 - 362 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 6T41A 2.45 Inactive DFGin‑BLBminus in-in out-out nonTYR APEdihe_aanoi APEdist_nnnn MFE Type1 1 - 359 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 5HBHA 2.5 Inactive DFGin‑BLBplus in-in out-out nonTYR APEdihe_aaioi APEdist_nnoo 5Y7 Type1 1 - 361 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 3RGFA 2.2 Inactive DFGout‑BBAminus in-out out-out nonTYR APEdihe_aaioi APEdist_nnno BAX Type2 1 - 353 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 4F6UA 2.1 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaioi APEdist_nnio 0SR Type2 1 - 359 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 4F6WA 2.39 Inactive DFGout‑BBAminus in-in none-none nonTYR APEdihe_aanii APEdist_nnnn 0SS Type2 1 - 359 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 4F7LA 2.9 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aanoi APEdist_nnnn 0SO Type2 1 - 359 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 4F7NA 2.65 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaioi APEdist_nnio 0SV Type2 1 - 361 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 5HVYA 2.39 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aaioi APEdist_oioo 66X Type2 1 - 359 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 6TPAA 2.8 Inactive DFGout‑BBAminus out-out out-out nonTYR APEdihe_aanoi APEdist_nnnn NZ8, NZ5, NZ5, NZ5 Type2, Allosteric, Allosteric, Allosteric 1 - 359 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 4F6SA 2.6 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 0SQ Type3 1 - 359 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 4F7JA 2.6 Inactive DFGout‑BBAminus in-in none-out nonTYR APEdihe_aaiii APEdist_nnno 0SU Type3 1 - 359 0 None None Cyclin-dependent kinase 8 Homo sapiens
CDK8_HUMAN 4F70A 3.0 Inactive None‑None in-in none-out nonTYR APEdihe_aaioi APEdist_nnno 0ST Type3 1 - 359 0 None None Cyclin-dependent kinase 8 Homo sapiens

CMGC_CDK8 (Cyclin-dependent kinase 8)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism