CDK8 (Cyclin-dependent kinase 8)

Group: CMGC
Uniprot: CDK8_HUMAN
Domain boundary: 20 - 335


Total number of chains: 37
Spatial Dihedral Chains Representative
DFGin BLAminus 9 AF-P49336-K1A
DFGin BLAplus 3 8TQ2A
DFGin BLBminus 14 6T41A
DFGin BLBplus 1 5HBHA
DFGout BBAminus 9 6TPAA
None None 1 4F70A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
AF-P49336-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 12 - 343 None None 0
5HBJA 3.0 None DFGin BLAminus in-in none-out 5Y8 Type1 1 - 361 None None 12
5ICPA 2.18 Inactive DFGin BLAminus in-in out-out 69Z Type1 1 - 362 None None 8
5IDNA 2.26 Inactive DFGin BLAminus in-in out-out 6A7 Type1 1 - 363 None None 16
5XQXA 2.3 Inactive DFGin BLAminus in-in in-out 8CC Type1 1 - 362 None None 13
5XS2A 2.04 Inactive DFGin BLAminus in-in in-out 8D6 Type1 1 - 363 None None 0
6QTJA 2.48 None DFGin BLAminus in-in none-out JHK Type1 1 - 359 None None 18
9H8CA 2.573 Inactive DFGin BLAminus in-in out-out A1IS8 Type1 1 - 361 None None 15
9H8SA 2.157 None DFGin BLAminus in-in out-none A1ITF Type1 1 - 362 None None 17
8TQ2A 3.8 Inactive DFGin BLAplus in-out in-in No_ligand No_ligand 1 - 359 None None 0
8TQCA 3.8 Inactive DFGin BLAplus in-out in-in No_ligand No_ligand 1 - 359 None None 0
8TQWa 8.2 Inactive DFGin BLAplus in-out in-in No_ligand No_ligand 1 - 359 None None 0
4G6LA 2.7 Inactive DFGin BLBminus in-in out-none No_ligand No_ligand 1 - 359 None None 12
5FGKA 2.36 Inactive DFGin BLBminus in-in none-out 5XG Type1 1 - 362 None None 17
5HBEA 2.38 Inactive DFGin BLBminus in-in out-out 5Y6 Type1 1 - 361 None None 9
5HNBA 2.35 Inactive DFGin BLBminus in-in out-none 62M Type1 1 - 359 None None 10
5I5ZA 2.6 Inactive DFGin BLBminus in-in out-none 68U Type1 1 - 362 None None 10
5IDPA 2.65 Inactive DFGin BLBminus in-in out-none 6A6 Type1 1 - 359 None None 10
4F7SA 2.2 Inactive DFGin BLBminus in-in out-none 0SW Type1 1 - 359 None None 9
5BNJA 2.64 Inactive DFGin BLBminus in-in out-none 4TV Type1 1 - 362 None None 11
6QTGA 2.7 Inactive DFGin BLBminus in-in none-out JH8 Type1 1 - 359 None None 19
4CRLA 2.4 Inactive DFGin BLBminus in-in out-out C1I Type1 1 - 359 None None 10
5CEIA 2.24 Inactive DFGin BLBminus in-in out-none 50R Type1 1 - 362 None None 9
6R3SA 2.19 Inactive DFGin BLBminus in-in out-none JRE Type1 1 - 362 None None 9
6Y0AA 2.19 Inactive DFGin BLBminus in-in out-none JRE Type1 1 - 362 None None 9
6T41A 2.45 Inactive DFGin BLBminus in-in out-none MFE Type1 1 - 359 None None 9
5HBHA 2.5 Inactive DFGin BLBplus in-in out-out 5Y7 Type1 1 - 361 None None 14
3RGFA 2.2 Inactive DFGout BBAminus in-out out-out BAX Type2 1 - 353 None None 16
4F6UA 2.1 Inactive DFGout BBAminus in-in none-out 0SR Type2 1 - 359 None None 17
4F6WA 2.39 Inactive DFGout BBAminus in-in none-none 0SS Type2 1 - 359 None None 18
4F7LA 2.9 Inactive DFGout BBAminus in-in none-none 0SO Type2 1 - 359 None None 20
4F7NA 2.65 Inactive DFGout BBAminus in-in none-out 0SV Type2 1 - 361 None None 17
5HVYA 2.39 Inactive DFGout BBAminus out-out out-out 66X Type2 1 - 359 None None 12
6TPAA 2.8 Inactive DFGout BBAminus out-out out-none NZ8 NZ5 NZ5 NZ5 Type2 Allosteric Allosteric Allosteric 1 - 359 None None 16
4F6SA 2.6 Inactive DFGout BBAminus in-in none-out 0SQ Type3 1 - 359 None None 17
4F7JA 2.6 Inactive DFGout BBAminus in-in none-out 0SU Type3 1 - 359 None None 18
4F70A 3.0 Inactive None None in-in none-out 0ST Type3 1 - 359 None None 20

CDK8 (Cyclin-dependent kinase 8)

Group: CMGC
Total number of chains: 37
Spatial Dihedral Chains Representative
DFGin BLAminus 9 AF-P49336-K1A
DFGin BLAplus 3 8TQ2A
DFGin BLBminus 14 6T41A
DFGin BLBplus 1 5HBHA
DFGout BBAminus 9 6TPAA
None None 1 4F70A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens CDK8_HUMAN AF-P49336-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 12 - 343 None None 0
Homo sapiens CDK8_HUMAN 5HBJA 3.0 None DFGin BLAminus in-in none-out 5Y8 Type1 1 - 361 None None 12
Homo sapiens CDK8_HUMAN 5ICPA 2.18 Inactive DFGin BLAminus in-in out-out 69Z Type1 1 - 362 None None 8
Homo sapiens CDK8_HUMAN 5IDNA 2.26 Inactive DFGin BLAminus in-in out-out 6A7 Type1 1 - 363 None None 16
Homo sapiens CDK8_HUMAN 5XQXA 2.3 Inactive DFGin BLAminus in-in in-out 8CC Type1 1 - 362 None None 13
Homo sapiens CDK8_HUMAN 5XS2A 2.04 Inactive DFGin BLAminus in-in in-out 8D6 Type1 1 - 363 None None 0
Homo sapiens CDK8_HUMAN 6QTJA 2.48 None DFGin BLAminus in-in none-out JHK Type1 1 - 359 None None 18
Homo sapiens CDK8_HUMAN 9H8CA 2.573 Inactive DFGin BLAminus in-in out-out A1IS8 Type1 1 - 361 None None 15
Homo sapiens CDK8_HUMAN 9H8SA 2.157 None DFGin BLAminus in-in out-none A1ITF Type1 1 - 362 None None 17
Homo sapiens CDK8_HUMAN 8TQ2A 3.8 Inactive DFGin BLAplus in-out in-in No_ligand No_ligand 1 - 359 None None 0
Homo sapiens CDK8_HUMAN 8TQCA 3.8 Inactive DFGin BLAplus in-out in-in No_ligand No_ligand 1 - 359 None None 0
Homo sapiens CDK8_HUMAN 8TQWa 8.2 Inactive DFGin BLAplus in-out in-in No_ligand No_ligand 1 - 359 None None 0
Homo sapiens CDK8_HUMAN 4G6LA 2.7 Inactive DFGin BLBminus in-in out-none No_ligand No_ligand 1 - 359 None None 12
Homo sapiens CDK8_HUMAN 5FGKA 2.36 Inactive DFGin BLBminus in-in none-out 5XG Type1 1 - 362 None None 17
Homo sapiens CDK8_HUMAN 5HBEA 2.38 Inactive DFGin BLBminus in-in out-out 5Y6 Type1 1 - 361 None None 9
Homo sapiens CDK8_HUMAN 5HNBA 2.35 Inactive DFGin BLBminus in-in out-none 62M Type1 1 - 359 None None 10
Homo sapiens CDK8_HUMAN 5I5ZA 2.6 Inactive DFGin BLBminus in-in out-none 68U Type1 1 - 362 None None 10
Homo sapiens CDK8_HUMAN 5IDPA 2.65 Inactive DFGin BLBminus in-in out-none 6A6 Type1 1 - 359 None None 10
Homo sapiens CDK8_HUMAN 4F7SA 2.2 Inactive DFGin BLBminus in-in out-none 0SW Type1 1 - 359 None None 9
Homo sapiens CDK8_HUMAN 5BNJA 2.64 Inactive DFGin BLBminus in-in out-none 4TV Type1 1 - 362 None None 11
Homo sapiens CDK8_HUMAN 6QTGA 2.7 Inactive DFGin BLBminus in-in none-out JH8 Type1 1 - 359 None None 19
Homo sapiens CDK8_HUMAN 4CRLA 2.4 Inactive DFGin BLBminus in-in out-out C1I Type1 1 - 359 None None 10
Homo sapiens CDK8_HUMAN 5CEIA 2.24 Inactive DFGin BLBminus in-in out-none 50R Type1 1 - 362 None None 9
Homo sapiens CDK8_HUMAN 6R3SA 2.19 Inactive DFGin BLBminus in-in out-none JRE Type1 1 - 362 None None 9
Homo sapiens CDK8_HUMAN 6Y0AA 2.19 Inactive DFGin BLBminus in-in out-none JRE Type1 1 - 362 None None 9
Homo sapiens CDK8_HUMAN 6T41A 2.45 Inactive DFGin BLBminus in-in out-none MFE Type1 1 - 359 None None 9
Homo sapiens CDK8_HUMAN 5HBHA 2.5 Inactive DFGin BLBplus in-in out-out 5Y7 Type1 1 - 361 None None 14
Homo sapiens CDK8_HUMAN 3RGFA 2.2 Inactive DFGout BBAminus in-out out-out BAX Type2 1 - 353 None None 16
Homo sapiens CDK8_HUMAN 4F6UA 2.1 Inactive DFGout BBAminus in-in none-out 0SR Type2 1 - 359 None None 17
Homo sapiens CDK8_HUMAN 4F6WA 2.39 Inactive DFGout BBAminus in-in none-none 0SS Type2 1 - 359 None None 18
Homo sapiens CDK8_HUMAN 4F7LA 2.9 Inactive DFGout BBAminus in-in none-none 0SO Type2 1 - 359 None None 20
Homo sapiens CDK8_HUMAN 4F7NA 2.65 Inactive DFGout BBAminus in-in none-out 0SV Type2 1 - 361 None None 17
Homo sapiens CDK8_HUMAN 5HVYA 2.39 Inactive DFGout BBAminus out-out out-out 66X Type2 1 - 359 None None 12
Homo sapiens CDK8_HUMAN 6TPAA 2.8 Inactive DFGout BBAminus out-out out-none NZ8 NZ5 NZ5 NZ5 Type2 Allosteric Allosteric Allosteric 1 - 359 None None 16
Homo sapiens CDK8_HUMAN 4F6SA 2.6 Inactive DFGout BBAminus in-in none-out 0SQ Type3 1 - 359 None None 17
Homo sapiens CDK8_HUMAN 4F7JA 2.6 Inactive DFGout BBAminus in-in none-out 0SU Type3 1 - 359 None None 18
Homo sapiens CDK8_HUMAN 4F70A 3.0 Inactive None None in-in none-out 0ST Type3 1 - 359 None None 20

CDK8 (Cyclin-dependent kinase 8)

No non-human structures known.