Ligand: F

Total number of chains: 168
Active chains: 39
Total number of genes: 62
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 78 46.4% 4AW0A
DFGin ABAminus 20 11.9% 4C57A
DFGin BLAplus 19 11.3% 9UHIA
DFGin None 16 9.5% 8B9EA
DFGin BLBplus 10 6.0% 3ZCLA
DFGout None 9 5.4% 3VO3A
DFGout BBAminus 8 4.8% 4MXCA
DFGin BLBminus 3 1.8% 5XYYA
DFGin BLBtrans 2 1.2% 2R3IA
None None 2 1.2% 5IEXA
DFGinter None 1 0.6% 4EBWA

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC AKT1 AKT1_HUMAN 4EKLA P31749 144 478 480.0 0RF:501 Type1 Active DFGin 6.496 13.423 BLAminus -130.08, 156.46 77.16, 99.77 -112.66, 14.16 298.65, 90.33 -61.32, -30.96 in-in in 8.958 Saltbr-in 2.452 HRD-in -78.38, -44.96 68.93, -13.6 in-in-in SNCiii in-in ActLoopNT-in 2.757 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.83, 160.76 APE9-dihe-na 116.71, 166.32 APE8-dihe-in -83.66, 133.51 APE8-rot-in 293.53 APE67-dihe-in -68.09, -18.95 -43.13, -46.31 APE12-dist-in 8.36 APE11-dist-in 11.512 APE10-dist-in 6.011 APE9-dist-in 4.443 S473D TPO308 TPO308 XRAY 2.0 0.175 0.235 A 341 330 0 0 0 0 [[150, 408]] 1.0 4ekl AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC GRK5 GRK5_HUMAN 9BRPA P34947 25 542 590.0 A1ARF:601 Type1 Inactive DFGin 6.253 12.479 ABAminus -116.3, -61.02 -91.04, 101.81 -97.25, 10.66 289.92, 84.11 -59.57, -18.7 in-in in 8.91 Saltbr-in 3.037 HRD-in -85.07, -56.86 71.89, 13.22 in-in-in SNCiii in-in ActLoopNT-in 3.105 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.18, 177.63 APE9-dihe-na 122.23, -155.28 APE8-dihe-in -122.73, 136.27 APE8-rot-in 286.0 APE67-dihe-inflip 100.9, -21.88 -54.82, 128.22 APE12-dist-in 9.574 APE11-dist-in 11.932 APE10-dist-in 6.253 APE9-dist-in 4.143 D311N None None XRAY 2.8 0.245 0.283 A 598 502 0 0 0 0 [[186, 448]] 1.0 9brp AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BREA P34947 25 542 590.0 W3F:601 Type1 Active DFGin 6.176 12.564 BLAminus -128.67, 172.15 57.35, 77.75 -93.22, 24.8 286.17, 72.14 -63.15, -21.99 in-in in 8.801 Saltbr-in 2.458 HRD-in -88.2, -51.09 67.29, 13.94 in-in-in SNCiii in-in ActLoopNT-in 3.127 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.49, 165.19 APE9-dihe-na 125.58, -150.88 APE8-dihe-in -124.55, 138.39 APE8-rot-in 312.36 APE67-dihe-inflip 92.11, -16.19 -53.44, 132.83 APE12-dist-in 9.943 APE11-dist-in 12.131 APE10-dist-in 6.337 APE9-dist-in 4.122 D311N None None XRAY 2.8 0.215 0.26 A 598 503 0 0 0 0 [[186, 448]] 1.0 9bre AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 8UAQA P34947 25 542 590.0 W3F:601 Type1 Inactive DFGin 6.02 12.841 None -112.48, -65.82 -86.97, 96.33 -93.06, 17.75 286.66, 70.13 -64.2, -19.76 in-in in 9.334 Saltbr-in 3.369 HRD-in -90.24, -57.5 70.99, -0.54 in-in-in SNCiii in-in ActLoopNT-in 3.037 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.56, 170.13 APE9-dihe-na 119.68, -157.85 APE8-dihe-in -112.7, 143.6 APE8-rot-in 314.4 APE67-dihe-inflip 89.64, -4.73 -59.54, 131.81 APE12-dist-in 9.916 APE11-dist-in 12.102 APE10-dist-in 6.306 APE9-dist-in 4.174 D311N None None XRAY 2.8 0.232 0.277 A 598 501 0 0 0 0 [[186, 448]] 1.0 8uaq AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC PDPK1 PDPK1_HUMAN 4AW0A O15530 75 359 556.0 ATP:500,MJF:600 ATPlike,Allosteric Active DFGin 6.531 14.993 BLAminus -134.84, 177.25 78.73, 76.19 -106.3, 8.53 283.51, 97.11 -69.63, -19.36 in-in in 8.595 Saltbr-in 3.009 HRD-in -83.05, -53.03 79.45, -12.94 in-in-in SNCiii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.69, 159.04 APE9-dihe-na 139.48, -167.8 APE8-dihe-in -131.87, 132.42 APE8-rot-in 295.45 APE67-dihe-in -61.29, -25.28 -54.74, -42.17 APE12-dist-in 7.509 APE11-dist-in 10.601 APE10-dist-in 5.026 APE9-dist-in 3.58 Y288G,Q292A SEP241 SEP241,CME260 XRAY 1.43 0.171 0.188 A 311 285 0 0 0 0 [[82, 342]] 1.0 4aw0 AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PRKCH KPCL_HUMAN 8FP1A P24723 349 676 683.0 XXF:9000 Type1 Active DFGin 6.04 12.861 BLAminus -134.17, 160.39 76.6, 103.68 -113.44, 14.82 306.37, 103.97 -62.81, -37.48 in-in in 8.529 Saltbr-in 2.747 HRD-in -71.28, -48.4 60.66, 8.21 in-in-in SNCiii in-in ActLoopNT-in 3.042 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -168.52, 169.89 APE9-dihe-na 121.68, 166.05 APE8-dihe-in -83.39, 128.15 APE8-rot-in 297.95 APE67-dihe-in -61.25, -27.98 -43.8, -44.17 APE12-dist-in 8.666 APE11-dist-in 11.701 APE10-dist-in 6.365 APE9-dist-in 3.566 S675E TPO513,TPO656 TPO513,TPO656 XRAY 1.85 0.2 0.234 A 353 328 0 0 0 0 [[355, 614]] 1.0 8fp1 AGC_PRKCH_HUMAN AGC 1.6e-97 331.6 1 260 260 496 497 498 500 502 384 403 407 476 478 477 479 536 524 519 518 517 516 515 514 513 434 Protein kinase C eta type
CAMK AURKA AURKA_HUMAN 8C1DA O14965 127 388 403.0 T2F:401,ADP:402,T5L:405 Allosteric,ATPlike,Allosteric Inactive DFGin 5.59 14.77 BLAminus -129.39, 179.64 57.3, 80.97 -92.88, 23.53 280.13, 79.47 -56.16, -33.44 in-in in 9.306 Saltbr-in 2.936 HRD-in -72.1, -50.49 67.69, -1.24 in-in-out SNCiio in-out ActLoopNT-in 2.796 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 144.85 APE8-dihe-in -64.26, 154.27 APE8-rot-out 88.6 APE67-dihe-in -39.49, -36.75 -82.32, -6.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.088 C290A None None XRAY 2.115 0.212 0.238 A 265 259 3 0 0 3 [[133, 383]] 1.0 8c1d CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2W1FA O14965 127 389 403.0 L0F:61390 Type1 Inactive DFGin 5.655 15.703 BLAminus -96.26, 172.45 62.06, 107.69 -118.91, 38.89 289.12, 66.42 -59.62, -48.4 out-out out 10.139 Saltbr-out 5.12 HRD-in -78.79, -54.88 78.03, -25.41 out-in-out SNCoio in-out ActLoopNT-in 2.676 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -157.03 APE8-dihe-in -58.47, 105.92 APE8-rot-out 190.33 APE67-dihe-in -42.4, -27.58 -64.36, -20.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.774 None None None XRAY 2.85 0.246 0.348 A 275 253 10 0 0 10 [[133, 383]] 1.0 2w1f CAMK_AURKA_HUMAN CAMK 6.7e-80 274.0 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3O51A O14965 126 388 403.0 LJF:1 Type1.5_Front Inactive DFGout 12.921 9.215 None -125.94, 46.56 -78.14, 156.47 -164.09, 999.0 59.42, 112.33 999.0, 999.0 out-none out 12.863 Saltbr-none 999.0 HRD-out -126.02, 153.87 -92.88, -115.51 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -57.91, -10.7 999.0, -51.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.288 0.304 A 267 246 17 0 0 17 [[133, 383]] 1.0 3o51 CAMK_AURKA_HUMAN CAMK 6e-80 274.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK CAMK2A KCC2A_HUMAN 2VZ6A Q9UQM7 9 299 478.0 FEF:60600 Type1 Active DFGin 7.124 13.93 BLAminus -130.3, 144.9 77.59, 104.3 -118.45, 37.91 281.19, 70.53 -60.86, -31.43 in-in in 9.032 Saltbr-in 2.623 HRD-in -71.43, -45.76 75.34, -9.9 in-in-in SNCiii in-in ActLoopNT-in 2.805 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.76, 148.02 APE9-dihe-na 132.07, -168.34 APE8-dihe-in -120.79, 126.49 APE8-rot-in 299.71 APE67-dihe-in -63.07, -18.83 -35.01, -58.7 APE12-dist-in 10.327 APE11-dist-in 11.819 APE10-dist-in 5.993 APE9-dist-in 3.832 None None None XRAY 2.3 0.165 0.203 A 313 289 2 0 0 0 [[13, 271]] 1.0 2vz6 CAMK_CAMK2A_HUMAN CAMK 1.6e-96 328.7 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 2VZ6B Q9UQM7 9 300 478.0 FEF:60600 Type1 Active DFGin 6.865 14.032 BLAminus -131.92, 139.26 77.54, 110.88 -122.08, 32.95 286.68, 71.96 -61.55, -26.54 in-in in 9.31 Saltbr-in 2.931 HRD-in -73.12, -44.65 73.93, -20.22 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.21, 149.78 APE9-dihe-na 143.11, -171.05 APE8-dihe-in -118.3, 128.44 APE8-rot-in 303.95 APE67-dihe-in -66.72, -18.78 -39.97, -52.82 APE12-dist-in 10.252 APE11-dist-in 11.756 APE10-dist-in 5.996 APE9-dist-in 3.963 None None None XRAY 2.3 0.165 0.203 B 313 292 0 0 0 0 [[13, 271]] 1.0 2vz6 CAMK_CAMK2A_HUMAN CAMK 1.6e-96 328.7 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CHEK1 CHK1_HUMAN 8E80A O14757 8 271 476.0 UUF:301 Type1 Active DFGin 6.948 13.561 BLAminus -116.38, 163.51 69.37, 105.0 -111.89, 20.17 292.16, 81.73 -65.53, -30.68 in-in in 8.579 Saltbr-in 2.859 HRD-in -73.57, -45.75 72.69, 0.21 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.33, 170.54 APE9-dihe-na 117.83, -149.18 APE8-dihe-in -134.92, 121.74 APE8-rot-in 303.05 APE67-dihe-in -62.91, -20.27 -44.12, -51.23 APE12-dist-in 9.365 APE11-dist-in 11.644 APE10-dist-in 6.142 APE9-dist-in 3.497 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.49 0.209 0.242 A 297 258 6 0 0 0 [[9, 265]] 1.0 8e80 CAMK_CHEK1_HUMAN CAMK 4.8e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK2 CHK2_HUMAN 2YCFA O96017 210 510 543.0 YCF:600 Type1 Inactive DFGin 6.651 14.425 BLAminus -133.14, 179.08 68.92, 89.26 -105.02, 26.49 290.18, 77.38 -65.99, -23.19 in-out in 9.994 Saltbr-out 8.56 HRD-in -70.72, -52.98 75.15, -0.9 out-in-out SNCoio in-out ActLoopNT-in 2.905 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -72.28, -26.54 APE9-dihe-na -96.81, -179.54 APE8-dihe-in -85.38, 132.85 APE8-rot-in 297.44 APE67-dihe-in -44.53, -40.92 -82.1, 28.65 APE12-dist-out 25.231 APE11-dist-out 27.289 APE10-dist-out 29.363 APE9-dist-out 33.105 None None None XRAY 1.77 0.197 0.218 A 322 286 15 0 0 0 [[220, 486]] 1.0 2ycf CAMK_CHEK2_HUMAN CAMK 2e-85 292.2 1 256 256 367 368 369 371 373 249 273 277 344 346 345 347 409 394 389 388 387 386 385 384 383 302 Serine/threonine-protein kinase Chk2
CAMK DAPK1 DAPK1_HUMAN 6AARA P53355 2 277 1430.0 9TF:300 Type1 Inactive DFGin 6.743 14.342 BLAminus -121.31, 178.32 64.29, 78.62 -87.38, 15.28 286.92, 75.84 -59.31, -26.74 in-in in 9.386 Saltbr-in 2.811 HRD-in -76.03, -46.41 70.92, -12.19 in-in-out SNCiio in-out ActLoopNT-in 2.921 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -137.91, 116.13 APE9-dihe-na -97.58, -145.9 APE8-dihe-in -81.4, 124.5 APE8-rot-in 302.0 APE67-dihe-in -55.21, -31.9 -47.73, -42.04 APE12-dist-in 11.019 APE11-dist-out 6.26 APE10-dist-out 9.242 APE9-dist-in 4.805 None None None XRAY 1.95 0.182 0.22 A 293 269 7 0 0 0 [[13, 275]] 1.0 6aar CAMK_DAPK1_HUMAN CAMK 6.1e-95 323.3 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK MAPKAPK2 MAPK2_HUMAN 3M42A P49137 47 364 400.0 HGF:365 Type1 None DFGin 4.265 13.765 BLAminus -127.28, 170.7 71.87, 101.44 -103.87, 20.75 277.01, 69.5 -61.92, -8.22 in-in in 9.26 Saltbr-in 3.091 HRD-in -73.72, -58.45 76.25, 11.76 in-in-none SNCiin in-none ActLoopNT-in 2.912 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 P237G None None XRAY 2.68 0.186 0.232 A 299 290 7 0 0 0 [[63, 325]] 1.0 3m42 CAMK_MAPKAPK2_HUMAN CAMK 1.9e-36 228.6 3 154 236 206 207 208 210 212 93 104 108 183 185 184 186 245 0 0 0 0 0 0 0 0 139 MAP kinase-activated protein kinase 2
CAMK MELK MELK_HUMAN 5IH9A Q14680 3 327 651.0 6BF:60401 Type1 None DFGin 6.939 15.146 BLAminus -123.48, 176.08 58.26, 79.91 -95.72, 21.84 280.98, 78.3 -67.92, -25.97 in-in in 8.72 Saltbr-in 2.587 HRD-in -71.83, -48.59 72.02, -0.04 in-in-none SNCiin in-none ActLoopNT-in 2.992 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -4.81 APE8-rot-in 291.01 APE67-dihe-in -55.95, -27.86 -55.75, -43.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.79 0.174 0.2 A 335 307 18 0 0 14 [[11, 263]] 1.0 5ih9 CAMK_MELK_HUMAN CAMK 9.7e-89 303.1 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK PIM1 PIM1_HUMAN 5KGIA P11309 33 305 313.0 6SF:414 Type1 Active DFGin 6.196 14.678 BLAminus -128.85, 173.72 58.37, 80.83 -91.15, 15.65 283.15, 78.86 -67.29, -15.19 in-in in 8.898 Saltbr-in 2.699 HRD-na-A -66.85, -48.52 69.49, 3.32 in-in-in SNCiii in-in ActLoopNT-in 2.854 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.48, 30.3 APE9-dihe-na -88.67, -155.26 APE8-dihe-in -89.24, 121.14 APE8-rot-in 310.96 APE67-dihe-in -66.24, -12.88 -55.29, -44.34 APE12-dist-in 9.723 APE11-dist-in 8.735 APE10-dist-in 5.642 APE9-dist-in 3.74 None None None XRAY 2.13 0.173 0.186 A 276 273 0 0 0 0 [[38, 290]] 1.0 5kgi CAMK_PIM1_HUMAN CAMK 2.5e-65 226.2 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 6L13A P11309 33 305 313.0 E2F:401 Type1 Active DFGin 6.19 14.786 BLAminus -130.24, 168.2 68.46, 80.68 -89.17, 16.05 288.1, 80.31 -69.01, -19.61 in-in in 9.105 Saltbr-in 2.936 HRD-na-A -68.46, -51.8 71.9, 8.52 in-in-in SNCiii in-in ActLoopNT-in 2.778 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.76, 29.56 APE9-dihe-na -92.34, -153.25 APE8-dihe-in -98.43, 124.2 APE8-rot-in 303.55 APE67-dihe-in -68.48, -12.49 -58.68, -45.06 APE12-dist-in 9.5 APE11-dist-in 8.511 APE10-dist-in 5.099 APE9-dist-in 3.659 None SEP261 SEP261 XRAY 2.24 0.18 0.214 A 289 273 0 0 0 0 [[38, 290]] 1.0 6l13 CAMK_PIM1_HUMAN CAMK 3e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 2O65A P11309 33 306 313.0 MYF:501 Type1 Active DFGin 5.773 14.223 BLAminus -134.9, 170.04 60.08, 89.22 -101.35, 10.62 287.34, 92.73 -63.96, -9.9 in-in in 8.704 Saltbr-in 2.471 HRD-na-A -65.14, -47.59 70.03, -4.07 in-in-in SNCiii in-in ActLoopNT-in 2.98 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.66, 34.64 APE9-dihe-na -104.35, -148.26 APE8-dihe-in -83.11, 121.1 APE8-rot-in 316.59 APE67-dihe-in -62.15, -16.44 -57.04, -47.52 APE12-dist-in 9.988 APE11-dist-in 8.628 APE10-dist-in 5.289 APE9-dist-in 4.136 None None None XRAY 2.85 0.21 0.262 A 293 274 0 0 0 0 [[38, 290]] 1.0 2o65 CAMK_PIM1_HUMAN CAMK 3.2e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 8R0WA P11309 33 305 313.0 XGF:405 Type1 Active DFGin 5.997 14.384 BLAminus -131.73, 166.77 65.97, 82.46 -89.79, 16.41 289.35, 79.56 -63.02, -16.4 in-in in 8.812 Saltbr-in 2.643 HRD-na-A -73.15, -45.35 65.43, 10.88 in-in-in SNCiii in-in ActLoopNT-in 2.855 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.23, 17.26 APE9-dihe-na -81.93, -156.28 APE8-dihe-in -91.39, 121.88 APE8-rot-in 296.84 APE67-dihe-in -71.92, -8.94 -64.52, -38.27 APE12-dist-in 9.559 APE11-dist-in 8.479 APE10-dist-in 5.116 APE9-dist-in 3.713 R250G SEP261 SEP261 XRAY 1.95 0.167 0.201 A 313 273 0 0 0 0 [[38, 290]] 1.0 8r0w CAMK_PIM1_HUMAN CAMK 1.5e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 8AFRA P11309 33 305 313.0 M0F:401 Type1 Active DFGin 6.024 14.406 BLAminus -126.46, 177.16 55.61, 83.44 -89.48, 19.88 284.93, 74.96 -67.33, -13.52 in-in in 8.831 Saltbr-in 2.648 HRD-na-A -72.52, -48.51 66.56, 10.77 in-in-in SNCiii in-in ActLoopNT-in 2.815 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.4, 19.87 APE9-dihe-na -78.39, -149.93 APE8-dihe-in -97.85, 123.61 APE8-rot-in 301.25 APE67-dihe-in -68.16, -10.25 -64.9, -40.75 APE12-dist-in 9.727 APE11-dist-in 8.467 APE10-dist-in 5.304 APE9-dist-in 3.645 R250G SEP261 SEP261 XRAY 2.15 0.166 0.191 A 309 264 7 0 0 0 [[38, 290]] 1.0 8afr CAMK_PIM1_HUMAN CAMK 3.1e-62 216.2 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CMGC CDK12 CDK12_HUMAN 8BU5B Q9NYV4 713 1044 1490.0 RMF:1101 Type1 Inactive DFGin 6.801 14.701 ABAminus -126.95, -66.04 -93.95, 105.24 -102.41, 30.18 293.69, 100.66 -84.84, -22.58 in-out in 8.305 Saltbr-out 3.933 HRD-out -78.59, 106.12 -94.17, 5.74 out-in-out SNCoio in-out ActLoopNT-in 2.828 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -136.91, -22.25 APE9-dihe-na -109.89, 157.52 APE8-dihe-in -56.01, 131.78 APE8-rot-in 308.02 APE67-dihe-in -60.99, -26.61 -52.03, -40.26 APE12-dist-out 14.28 APE11-dist-in 11.941 APE10-dist-in 7.36 APE9-dist-in 3.767 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 B 344 332 0 0 0 0 [[727, 1020]] 1.0 8bu5 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU5H Q9NYV4 713 1043 1490.0 RMF:1101 Type1 Inactive DFGin 7.015 14.978 ABAminus -128.46, -54.53 -90.71, 103.12 -97.22, 31.8 290.43, 81.59 -85.33, -25.69 in-in in 8.479 Saltbr-in 3.527 HRD-in -73.55, -49.58 63.85, -4.76 in-in-in SNCiii in-in ActLoopNT-in 2.629 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.5, -28.02 APE9-dihe-na -97.36, 153.71 APE8-dihe-in -57.72, 135.61 APE8-rot-in 311.07 APE67-dihe-in -63.38, -27.52 -50.57, -39.59 APE12-dist-in 13.941 APE11-dist-in 12.128 APE10-dist-in 7.258 APE9-dist-in 3.497 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 H 344 331 0 0 0 0 [[727, 1020]] 1.0 8bu5 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUNB Q9NYV4 715 1041 1490.0 RNF:61101 Type1 Inactive DFGin 7.009 15.297 ABAminus -131.36, -49.43 -89.83, 91.44 -92.44, 32.63 287.3, 77.5 -75.27, -18.22 in-in in 7.748 Saltbr-in 3.279 HRD-in -75.67, -53.71 75.4, -0.11 in-in-in SNCiii in-in ActLoopNT-in 2.923 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -107.12, -39.12 APE9-dihe-na -104.98, 151.97 APE8-dihe-in -58.93, 142.91 APE8-rot-in 279.94 APE67-dihe-in -65.42, -33.6 -55.06, -35.14 APE12-dist-in 13.388 APE11-dist-in 11.695 APE10-dist-in 7.099 APE9-dist-in 3.657 K965R TPO893 TPO893 XRAY 3.08 0.187 0.211 B 344 327 0 0 0 0 [[727, 1020]] 1.0 8bun CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUNH Q9NYV4 715 1043 1490.0 RNF:61101 Type1 Inactive DFGin 7.045 15.286 ABAminus -125.24, -50.09 -100.69, 94.75 -92.24, 30.97 286.18, 71.82 -75.42, -18.26 in-in in 7.834 Saltbr-in 3.373 HRD-in -77.6, -54.36 73.0, -1.25 in-in-in SNCiii in-in ActLoopNT-in 2.74 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.56, -41.65 APE9-dihe-na -95.79, 153.05 APE8-dihe-in -58.87, 144.43 APE8-rot-in 305.25 APE67-dihe-in -65.98, -31.29 -55.83, -37.71 APE12-dist-in 13.775 APE11-dist-in 11.972 APE10-dist-in 6.957 APE9-dist-in 3.478 K965R TPO893 TPO893 XRAY 3.08 0.187 0.211 H 344 329 0 0 0 0 [[727, 1020]] 1.0 8bun CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 9FMRE Q9NYV4 714 1042 1490.0 RMF:61101 Type1 Inactive DFGin 6.793 14.64 ABAminus -113.83, -79.52 -84.15, 118.47 -115.27, 16.16 293.54, 100.02 -64.02, -34.33 in-out in 9.633 Saltbr-out 3.612 HRD-out -79.17, 82.22 -59.96, 8.89 out-in-out SNCoio in-out ActLoopNT-in 3.026 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -148.14, -27.51 APE9-dihe-na -104.44, 148.12 APE8-dihe-in -51.45, 137.55 APE8-rot-in 306.02 APE67-dihe-in -70.5, -21.3 -54.61, -36.19 APE12-dist-out 14.298 APE11-dist-in 12.211 APE10-dist-in 7.469 APE9-dist-in 3.767 None TPO893 TPO893 XRAY 3.9 0.209 0.25 E 351 329 0 0 0 0 [[727, 1020]] 1.0 9fmr CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 9FMRH Q9NYV4 714 1044 1490.0 RMF:61101 Type1 Inactive DFGin 6.801 14.603 ABAminus -113.95, -78.4 -84.85, 124.02 -118.87, 17.95 291.29, 89.7 -63.88, -35.4 in-in in 8.592 Saltbr-in 3.552 HRD-in -72.47, -40.65 59.82, 5.57 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.74, -27.71 APE9-dihe-na -103.25, 148.34 APE8-dihe-in -51.07, 136.63 APE8-rot-in 306.14 APE67-dihe-in -69.99, -21.15 -54.39, -34.8 APE12-dist-in 13.823 APE11-dist-in 12.098 APE10-dist-in 7.255 APE9-dist-in 3.608 None TPO893 TPO893 XRAY 3.9 0.209 0.25 H 351 331 0 0 0 0 [[727, 1020]] 1.0 9fmr CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUNE Q9NYV4 715 1039 1490.0 RNF:61101 Type1 Inactive DFGin 7.217 15.313 BLAminus -143.55, -179.06 50.55, 77.42 -92.12, 34.85 285.27, 76.47 -72.26, -18.51 in-in in 7.824 Saltbr-in 3.046 HRD-in -77.13, -53.65 75.0, -0.22 in-in-out SNCiio in-out ActLoopNT-in 2.924 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -105.31, -34.23 APE9-dihe-na -92.08, 151.91 APE8-dihe-in -57.84, 145.99 APE8-rot-out 175.35 APE67-dihe-in -65.98, -29.37 -55.72, -38.5 APE12-dist-in 13.18 APE11-dist-in 12.611 APE10-dist-in 7.008 APE9-dist-in 3.432 K965R TPO893 TPO893 XRAY 3.08 0.187 0.211 E 344 325 0 0 0 0 [[727, 1020]] 1.0 8bun CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8P81A Q9NYV4 716 1035 1490.0 RMF:1101 Type1 Active DFGin 7.095 14.446 BLAminus -134.83, -178.64 59.2, 72.19 -89.53, 34.88 291.56, 80.44 -67.97, -22.73 in-in in 8.359 Saltbr-in 3.057 HRD-in -81.5, -42.97 59.01, 18.94 in-in-in SNCiii in-in ActLoopNT-in 2.963 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.63, 165.61 APE9-dihe-na 67.08, 139.25 APE8-dihe-in -61.99, 152.33 APE8-rot-in 316.49 APE67-dihe-in -68.12, -20.85 -57.98, -41.98 APE12-dist-in 12.679 APE11-dist-in 10.561 APE10-dist-in 6.52 APE9-dist-in 3.212 None TPO893 TPO893 XRAY 2.68 0.212 0.255 A 351 320 0 0 0 0 [[727, 1020]] 1.0 8p81 CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU5E Q9NYV4 713 1043 1490.0 RMF:1101 Type1 Inactive DFGin 6.942 15.122 None -123.64, -63.66 -81.97, -51.09 56.28, 22.54 292.49, 98.9 -91.33, -28.22 in-out in 8.371 Saltbr-out 3.622 HRD-in -72.77, -54.57 74.45, -4.91 out-in-out SNCoio in-out ActLoopNT-in 2.759 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -134.16, -27.33 APE9-dihe-na -98.05, 157.33 APE8-dihe-in -51.55, 136.25 APE8-rot-in 308.17 APE67-dihe-in -63.16, -26.85 -49.17, -41.17 APE12-dist-out 14.125 APE11-dist-in 12.168 APE10-dist-in 7.286 APE9-dist-in 3.726 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 E 344 331 0 0 0 0 [[727, 1020]] 1.0 8bu5 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 9FMRB Q9NYV4 714 1047 1490.0 RMF:61101 Type1 Inactive DFGin 7.124 15.031 None -111.49, -74.26 -77.99, -72.15 68.85, 12.84 296.16, 89.8 -66.22, -36.51 in-out in 8.332 Saltbr-out 4.45 HRD-in -70.8, -35.56 62.81, 1.22 out-in-in SNCoii in-in ActLoopNT-in 3.072 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.03, -25.75 APE9-dihe-na -103.56, 146.88 APE8-dihe-in -51.72, 138.27 APE8-rot-in 305.58 APE67-dihe-in -69.51, -21.36 -53.61, -35.19 APE12-dist-in 13.987 APE11-dist-in 12.27 APE10-dist-in 7.331 APE9-dist-in 3.865 None TPO893 TPO893 XRAY 3.9 0.209 0.25 B 351 334 0 0 0 0 [[727, 1020]] 1.0 9fmr CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK16 CDK16_HUMAN 3MTLA Q00536 163 473 496.0 FEF:60668 Type1 Inactive DFGout 17.399 7.472 None -75.13, 154.32 -88.9, 77.74 -154.62, 116.54 227.56, 88.74 78.03, 21.89 in-in in 8.385 Saltbr-in 2.641 HRD-out -101.69, 108.56 -74.19, -25.04 in-out-out SNCioo out-out ActLoopNT-out 5.164 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 102.89 APE8-rot-out 156.53 APE67-dihe-in -61.54, -35.29 -78.56, -14.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S319D None None XRAY 2.4 0.198 0.263 A 324 293 18 0 0 12 [[165, 446]] 1.0 3mtl CMGC_CDK16_HUMAN CMGC 1.3e-83 286.9 1 301 301 303 304 305 307 309 194 211 215 283 285 284 286 344 331 326 325 324 323 322 321 320 241 Cyclin-dependent kinase 16
CMGC CDK2 CDK2_HUMAN 9ESWA P24941 1 294 298.0 IJF:60301,IJF:60302,IJF:60303,IJF:60304 Allosteric,Type1,Allosteric,Allosteric Active DFGin 6.515 15.297 BLAminus -143.94, 174.07 58.52, 82.55 -94.4, 25.35 278.47, 68.95 -74.76, -22.16 in-in in 8.637 Saltbr-in 3.197 HRD-in -81.26, -58.57 77.56, 16.21 in-in-in SNCiii in-in ActLoopNT-in 2.996 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -61.44, 160.94 APE9-dihe-na 81.67, 126.4 APE8-dihe-in -51.25, 136.17 APE8-rot-in 300.7 APE67-dihe-in -59.48, -16.12 -52.59, -48.63 APE12-dist-in 12.997 APE11-dist-in 11.897 APE10-dist-in 7.023 APE9-dist-in 3.204 None TPO160 TPO160 XRAY 2.38 0.233 0.239 A 302 294 0 0 0 0 [[4, 286]] 1.0 9esw CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9ESWC P24941 1 296 298.0 IJF:60301,IJF:60302,IJF:60303,IJF:60304 Allosteric,Type1,Allosteric,Allosteric Active DFGin 6.576 15.209 BLAminus -137.9, -176.23 48.55, 71.41 -85.05, 25.18 283.44, 66.65 -62.35, -32.95 in-in in 8.417 Saltbr-in 2.763 HRD-in -83.58, -58.72 75.84, 9.9 in-in-in SNCiii in-in ActLoopNT-in 2.887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.32, 151.2 APE9-dihe-na 72.23, 131.64 APE8-dihe-in -58.77, 140.82 APE8-rot-in 312.4 APE67-dihe-in -51.92, -26.23 -42.04, -57.02 APE12-dist-in 12.776 APE11-dist-in 10.195 APE10-dist-in 6.943 APE9-dist-in 3.236 None TPO160 TPO160 XRAY 2.38 0.233 0.239 C 302 269 27 0 0 0 [[4, 286]] 1.0 9esw CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9OB4A P24941 1 298 298.0 A1CAF:301 Type1 Active DFGin 7.07 15.433 BLAminus -140.78, 171.16 58.81, 81.21 -94.48, 18.25 279.35, 70.51 -60.63, -24.89 in-in in 8.702 Saltbr-in 2.578 HRD-in -77.49, -52.8 70.85, 9.99 in-in-in SNCiii in-in ActLoopNT-in 2.858 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -103.4, 171.78 APE9-dihe-na 71.79, 138.58 APE8-dihe-in -59.97, 144.28 APE8-rot-in 298.9 APE67-dihe-in -65.05, -23.77 -53.99, -47.04 APE12-dist-in 13.149 APE11-dist-in 12.232 APE10-dist-in 7.357 APE9-dist-in 3.261 None TPO160 TPO160 XRAY 1.95 0.211 0.251 A 301 298 0 0 0 0 [[4, 286]] 1.0 9ob4 CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4BCQA P24941 1 295 298.0 TJF:61296 Type1 Active DFGin 6.591 15.979 BLAminus -145.97, 170.46 62.82, 84.99 -99.38, 29.59 282.23, 71.6 -71.19, -18.61 in-in in 9.404 Saltbr-in 3.453 HRD-in -85.05, -58.94 78.36, 12.61 in-in-in SNCiii in-in ActLoopNT-in 3.147 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.8, 176.97 APE9-dihe-na 69.33, 133.29 APE8-dihe-in -55.38, 139.69 APE8-rot-in 304.09 APE67-dihe-in -55.84, -22.0 -49.63, -50.65 APE12-dist-in 13.625 APE11-dist-in 12.543 APE10-dist-in 7.498 APE9-dist-in 3.511 None TPO160 TPO160 XRAY 2.4 0.217 0.252 A 301 290 5 0 0 0 [[4, 286]] 1.0 4bcq CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4BCQC P24941 1 294 298.0 TJF:61295 Type1 Active DFGin 6.54 16.003 BLAminus -147.36, 170.23 59.21, 86.27 -98.9, 28.16 278.44, 72.82 -71.37, -12.42 in-in in 9.598 Saltbr-in 3.261 HRD-in -88.13, -59.99 74.18, 19.51 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.48, 157.26 APE9-dihe-na 69.58, 129.95 APE8-dihe-in -57.66, 135.49 APE8-rot-in 301.27 APE67-dihe-in -62.84, -20.05 -48.44, -46.81 APE12-dist-in 13.54 APE11-dist-in 10.682 APE10-dist-in 7.689 APE9-dist-in 3.66 None TPO160 TPO160 XRAY 2.4 0.217 0.252 C 301 292 2 0 0 0 [[4, 286]] 1.0 4bcq CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 7S9XA P24941 3 298 298.0 8KF:301 Type3 Inactive DFGin 9.152 14.904 BLBminus -140.51, 174.83 55.24, 52.61 -60.52, 155.06 283.44, 65.83 -96.54, 51.03 out-out out 17.021 Saltbr-out 17.405 HRD-in -80.98, -57.39 84.63, -18.55 out-out-out SNCooo out-out ActLoopNT-out 9.299 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 131.76 APE9-dihe-na -82.0, 133.39 APE8-dihe-in -82.83, 123.04 APE8-rot-in 299.71 APE67-dihe-in -59.76, -23.84 -102.49, -0.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.12 APE9-dist-out 11.022 None None None XRAY 1.69 0.231 0.262 A 298 269 27 0 0 12 [[4, 286]] 1.0 7s9x CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2W1HA P24941 1 298 298.0 L0F:1299 Type1 Inactive DFGin 10.307 17.775 BLBtrans -130.06, 151.5 79.56, 18.75 -69.93, 141.61 226.73, 121.67 69.65, -12.05 out-out out 14.489 Saltbr-out 16.038 HRD-in -88.39, -56.31 79.17, -16.22 out-out-out SNCooo out-out ActLoopNT-out 5.457 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 121.46 APE8-dihe-in -76.22, 142.93 APE8-rot-out 186.46 APE67-dihe-in -49.35, -36.85 -110.85, -4.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.805 None None None XRAY 2.15 0.263 0.308 A 298 283 15 0 0 11 [[4, 286]] 1.0 2w1h CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2R3IA P24941 1 298 298.0 SCF:60501 Type1 Inactive DFGin 10.929 18.24 BLBtrans -100.61, 149.54 71.45, 21.63 -58.2, 134.86 231.09, 103.4 83.18, -10.48 out-out out 15.057 Saltbr-out 16.345 HRD-in -91.01, -59.76 82.13, -15.3 out-out-out SNCooo out-out ActLoopNT-out 5.707 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.45, 127.61 APE9-dihe-na -74.97, 122.45 APE8-dihe-in -60.32, 144.67 APE8-rot-out 191.76 APE67-dihe-in -59.78, -26.25 -99.25, -5.87 APE12-dist-out 20.169 APE11-dist-out 17.538 APE10-dist-out 18.889 APE9-dist-out 9.991 None None CSD177 XRAY 1.28 0.178 0.202 A 299 291 7 0 0 0 [[4, 286]] 1.0 2r3i CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 5IEXA P24941 1 298 298.0 6AF:1001 Type1 Inactive None 11.106 18.344 None -105.6, 149.53 71.37, 22.65 -61.85, 135.15 236.62, 103.3 74.49, -10.58 out-out out 15.176 Saltbr-out 15.226 HRD-in -80.72, -65.3 84.99, -26.41 out-out-out SNCooo out-out ActLoopNT-out 5.802 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 111.81 APE8-dihe-in -112.57, 117.73 APE8-rot-in 277.98 APE67-dihe-in -67.92, -29.52 -99.02, -2.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.275 None None None XRAY 2.03 0.206 0.254 A 298 285 13 0 0 8 [[4, 286]] 1.0 5iex CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK6 CDK6_HUMAN 9PE7A Q00534 10 301 326.0 A1CIF:900 Type1 Inactive DFGin 6.872 13.127 BLBplus -137.4, 169.29 57.4, 61.63 -142.77, 164.35 61.09, 86.59 91.92, -16.71 out-out out 12.416 Saltbr-out 9.93 HRD-in -63.73, -52.58 73.19, -16.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 162.46 APE9-dihe-na -100.9, 174.34 APE8-dihe-in -134.69, 96.5 APE8-rot-in 306.93 APE67-dihe-in -54.43, -27.6 -93.0, -5.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 22.373 APE9-dist-out 12.123 E21V,K26T,T106R,Q149E None None XRAY 2.05 0.216 0.267 A 307 262 30 0 0 12 [[13, 300]] 1.0 9pe7 CMGC_CDK6_HUMAN CMGC 3.7e-84 289.5 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
CMGC CDK7 CDK7_HUMAN 8P71J P50613 10 310 346.0 X4F:60401 Type1 Active DFGin 6.832 15.304 BLAminus -139.46, 179.9 57.59, 64.02 -82.45, 17.71 282.17, 74.47 -64.72, -19.22 in-in in 8.103 Saltbr-in 2.694 HRD-in -67.33, -49.46 65.63, 5.51 in-in-in SNCiii in-in ActLoopNT-in 2.639 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.68, 168.49 APE9-dihe-na 67.33, 140.05 APE8-dihe-in -60.3, 143.93 APE8-rot-in 294.53 APE67-dihe-in -61.0, -25.19 -55.87, -41.76 APE12-dist-in 13.411 APE11-dist-in 11.192 APE10-dist-in 6.803 APE9-dist-in 3.276 None None None EM 2.0 999.0 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8p71 CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK8 CDK8_HUMAN 9H8SA P49336 1 362 464.0 A1ITF:60509 Type1 Inactive DFGin 7.344 13.924 BLAminus -119.28, 163.44 74.84, 82.25 -92.61, 11.91 298.93, 132.0 -87.41, 10.8 in-in in 8.612 Saltbr-in 2.624 HRD-in -75.25, -51.5 79.06, -6.52 in-out-out SNCioo out-out ActLoopNT-out 8.659 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 160.05 APE8-rot-out 75.96 APE67-dihe-in -54.19, -23.95 -111.96, 19.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.157 0.197 0.248 A 414 335 27 0 0 17 [[22, 335]] 1.0 9h8s CMGC_CDK8_HUMAN CMGC 6.3e-82 281.3 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CMGC CSNK2A1 CSK21_HUMAN 8AEMA P68400 3 329 391.0 LVF:407,ATP:408 Allosteric,ATPlike Active DFGin 7.399 16.187 BLAminus -114.2, -178.47 56.21, 75.05 -90.39, 15.9 296.69, 81.8 -66.43, -20.83 in-in in 9.132 Saltbr-in 2.816 HRD-in -72.91, -51.16 68.69, 11.11 in-in-in SNCiii in-in ActLoopNT-in 2.905 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.83, 169.06 APE9-dihe-na 58.87, 157.76 APE8-dihe-in -77.1, 150.54 APE8-rot-in 294.73 APE67-dihe-in -68.78, -13.55 -40.19, -53.95 APE12-dist-in 12.744 APE11-dist-in 10.417 APE10-dist-in 6.256 APE9-dist-in 3.215 R21S,K74A,K75A,K76A None None XRAY 1.6 0.19 0.212 A 328 327 0 0 0 0 [[39, 324]] 1.0 8aem CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 9EPWB P68400 3 333 391.0 A1H6F:406 Type1 Active DFGin 7.386 16.279 BLAminus -118.5, 178.76 54.91, 76.82 -86.63, 13.68 291.49, 81.55 -67.5, -20.83 out-in out 10.046 Saltbr-in 3.292 HRD-in -71.7, -52.07 70.7, 14.03 in-in-in SNCiii in-in ActLoopNT-in 2.882 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.62, 167.98 APE9-dihe-na 70.49, 159.89 APE8-dihe-in -76.41, 141.74 APE8-rot-in 289.66 APE67-dihe-in -68.82, -20.3 -42.56, -42.98 APE12-dist-in 12.795 APE11-dist-in 10.921 APE10-dist-in 6.279 APE9-dist-in 3.382 None None None XRAY 2.3 0.261 0.308 B 338 331 0 0 0 0 [[39, 324]] 1.0 9epw CMGC_CSNK2A1_HUMAN CMGC 1.4e-69 240.6 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 2ZJWA P68400 1 332 391.0 REF:336 Type1 Inactive DFGin 7.316 16.527 BLAminus -109.16, -168.7 44.38, 76.01 -90.89, 24.26 297.46, 77.89 -76.15, -7.13 in-in in 9.417 Saltbr-in 2.731 HRD-in -72.0, -50.11 70.44, 13.49 in-in-out SNCiio in-out ActLoopNT-in 2.907 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -14.58, 161.89 APE9-dihe-na 62.59, 163.98 APE8-dihe-in -84.5, 146.1 APE8-rot-out 153.88 APE67-dihe-in -63.0, -17.21 -40.84, -52.94 APE12-dist-in 12.607 APE11-dist-in 8.948 APE10-dist-in 5.933 APE9-dist-in 2.992 None None None XRAY 2.4 0.222 0.274 A 340 332 0 0 0 0 [[39, 324]] 1.0 2zjw CMGC_CSNK2A1_HUMAN CMGC 1.4e-69 240.5 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7I8AA P68400 3 329 391.0 A1B0F:401 Type1 Active DFGin 7.457 16.071 BLAminus -110.77, 179.22 49.98, 83.2 -97.8, 27.66 295.37, 80.49 -74.55, -21.62 in-in in 8.964 Saltbr-in 2.748 HRD-in -69.35, -49.91 66.48, 13.83 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.27, 172.69 APE9-dihe-na 60.01, 160.49 APE8-dihe-in -88.34, 150.2 APE8-rot-in 298.89 APE67-dihe-in -68.6, -15.9 -36.65, -52.88 APE12-dist-in 12.62 APE11-dist-in 10.174 APE10-dist-in 6.101 APE9-dist-in 3.048 R21S,K74A,K75A,K76A None None XRAY 1.84 0.196 0.234 A 328 323 4 0 0 0 [[39, 324]] 1.0 7i8a CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC DYRK1A DYR1A_HUMAN 6A1FA Q13627 134 483 763.0 9OF:807 Type1 Active DFGin 7.205 15.092 BLAminus -125.52, 173.04 69.56, 79.06 -100.37, 18.23 289.23, 81.85 -66.74, -28.25 in-in in 8.712 Saltbr-in 2.843 HRD-in -63.72, -44.37 75.39, -2.34 in-in-in SNCiii in-in ActLoopNT-in 2.826 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.51, 164.33 APE9-dihe-na 78.19, 142.16 APE8-dihe-in -71.23, 146.24 APE8-rot-in 287.31 APE67-dihe-in -64.89, -24.24 -54.81, -45.1 APE12-dist-in 13.001 APE11-dist-in 10.937 APE10-dist-in 7.397 APE9-dist-in 3.189 None PTR321 PTR321 XRAY 1.5 0.178 0.195 A 360 346 4 0 0 0 [[159, 479]] 1.0 6a1f CMGC_DYRK1A_HUMAN CMGC 8.3e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK2 DYRK2_HUMAN 7DH9A Q92630 215 538 601.0 H7F:601 Type1 Inactive DFGin 6.955 15.393 BLAminus -118.25, -176.44 52.33, 72.66 -86.4, 22.32 285.5, 71.17 -68.46, -16.6 in-in in 9.091 Saltbr-in 2.818 HRD-in -67.52, -48.86 77.78, -1.22 in-in-out SNCiio in-out ActLoopNT-in 2.826 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.21, 165.64 APE9-dihe-na 77.26, 152.01 APE8-dihe-in -71.35, 136.19 APE8-rot-out 186.16 APE67-dihe-in -56.24, -27.47 -53.15, -48.91 APE12-dist-in 13.085 APE11-dist-in 11.935 APE10-dist-in 7.588 APE9-dist-in 3.308 None PTR382,SEP458 PTR382,SEP458 XRAY 2.194 0.19 0.218 A 324 324 0 0 0 0 [[222, 535]] 1.0 7dh9 CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
CMGC GSK3B GSK3B_HUMAN 9PE9A P49841 36 382 420.0 A1CIF:900 Type1 Inactive DFGin 7.072 14.229 BLAminus -128.7, -179.96 59.31, 84.1 -97.11, 26.91 283.64, 74.63 -73.69, -18.15 in-in in 8.351 Saltbr-in 2.725 HRD-in -68.62, -45.57 65.7, 16.55 in-in-out SNCiio in-out ActLoopNT-in 2.925 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -143.94, 165.33 APE9-dihe-na 76.34, 152.28 APE8-dihe-in -69.82, 130.62 APE8-rot-out 176.66 APE67-dihe-in -58.68, -26.71 -39.69, -56.4 APE12-dist-in 13.28 APE11-dist-in 11.758 APE10-dist-in 7.093 APE9-dist-in 3.155 None PTR216 PTR216 XRAY 2.11 0.221 0.247 A 359 332 13 0 0 0 [[56, 340]] 1.0 9pe9 CMGC_GSK3B_HUMAN CMGC 2e-70 243.6 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 9PE9B P49841 36 382 420.0 A1CIF:900 Type1 Inactive DFGin 7.058 14.218 BLAminus -128.76, -179.81 59.6, 84.42 -97.78, 27.09 283.79, 74.38 -73.25, -17.71 in-in in 8.353 Saltbr-in 2.713 HRD-in -68.49, -44.82 64.55, 18.32 in-in-out SNCiio in-out ActLoopNT-in 2.94 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -144.27, 163.74 APE9-dihe-na 77.64, 152.05 APE8-dihe-in -69.14, 130.82 APE8-rot-out 177.12 APE67-dihe-in -58.92, -26.81 -39.96, -55.88 APE12-dist-in 13.36 APE11-dist-in 11.824 APE10-dist-in 7.161 APE9-dist-in 3.172 None PTR216 PTR216 XRAY 2.11 0.221 0.247 B 359 332 13 0 0 0 [[56, 340]] 1.0 9pe9 CMGC_GSK3B_HUMAN CMGC 2e-70 243.6 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 4PTEA P49841 36 382 420.0 2WF:501 Type1 Active DFGin 6.932 14.017 BLAminus -141.21, 178.04 57.99, 89.39 -100.23, 24.26 286.38, 75.9 -68.08, -19.02 in-in in 8.716 Saltbr-in 2.635 HRD-in -73.56, -44.45 69.11, 4.74 in-in-in SNCiii in-in ActLoopNT-in 2.792 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.74, 175.98 APE9-dihe-na 75.98, 148.82 APE8-dihe-in -103.79, 152.51 APE8-rot-in 295.33 APE67-dihe-inflip 95.08, -28.26 -38.95, 126.56 APE12-dist-in 12.979 APE11-dist-in 10.89 APE10-dist-in 5.883 APE9-dist-in 3.088 None None None XRAY 2.033 0.17 0.195 A 441 341 6 0 0 0 [[56, 340]] 1.0 4pte CMGC_GSK3B_HUMAN CMGC 3.7e-70 242.6 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 4PTEB P49841 36 385 420.0 2WF:501 Type1 Active DFGin 6.918 13.937 BLAminus -137.07, 179.43 58.52, 88.98 -101.38, 27.88 284.28, 76.88 -69.85, -20.65 in-in in 8.484 Saltbr-in 2.685 HRD-in -70.9, -46.61 73.05, 2.3 in-in-in SNCiii in-in ActLoopNT-in 2.887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -87.76, 178.59 APE9-dihe-na 72.73, 147.77 APE8-dihe-in -103.48, 150.66 APE8-rot-in 296.89 APE67-dihe-inflip 94.67, -27.57 -36.66, 125.81 APE12-dist-in 12.935 APE11-dist-in 10.88 APE10-dist-in 5.877 APE9-dist-in 3.154 None None None XRAY 2.033 0.17 0.195 B 441 347 3 0 0 0 [[56, 340]] 1.0 4pte CMGC_GSK3B_HUMAN CMGC 3.7e-70 242.6 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC MAPK1 MK01_HUMAN 5BVDA P28482 9 358 360.0 4VF:60401 Type1 None DFGin 7.012 14.82 BLAminus -120.88, -174.96 58.49, 83.25 -99.87, 23.43 283.53, 71.8 -56.85, -34.73 in-in in 9.264 Saltbr-in 2.627 HRD-in -80.64, -49.81 78.16, -6.37 in-in-none SNCiin in-none ActLoopNT-in 2.72 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 122.19 APE8-rot-in 306.38 APE67-dihe-in -62.44, -24.22 -51.26, -49.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.172 0.207 A 361 330 20 0 0 16 [[25, 313]] 1.0 5bvd CMGC_MAPK1_HUMAN CMGC 9.2e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8AO6A P28482 11 356 360.0 N9F:406 Type1 Inactive DFGin 6.771 16.337 BLAminus -129.81, 177.88 71.62, 78.81 -103.22, 23.44 283.23, 73.97 -64.0, -29.38 out-in out 10.371 Saltbr-in 2.597 HRD-in -72.45, -50.74 72.14, 4.83 in-in-out SNCiio in-out ActLoopNT-in 2.785 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -96.92, -36.24 APE9-dihe-na -66.98, 156.39 APE8-dihe-in -51.35, 125.27 APE8-rot-in 311.93 APE67-dihe-in -64.42, -17.18 -56.32, -47.54 APE12-dist-out 14.414 APE11-dist-in 11.107 APE10-dist-in 7.103 APE9-dist-in 4.264 None None CME127,CME161 XRAY 1.811 0.175 0.222 A 368 338 0 0 0 0 [[25, 313]] 1.0 8ao6 CMGC_MAPK1_HUMAN CMGC 9.9e-86 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8AO9A P28482 11 356 360.0 N4F:406 Type1 Inactive DFGin 6.837 16.45 BLAminus -129.5, 178.83 61.88, 81.37 -96.97, 21.21 286.14, 78.83 -59.7, -30.7 out-out out 10.301 Saltbr-out 3.765 HRD-in -72.95, -49.65 72.84, 3.98 out-in-out SNCoio in-out ActLoopNT-in 2.854 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -91.06, -44.4 APE9-dihe-na -60.28, 156.59 APE8-dihe-in -55.09, 130.24 APE8-rot-in 307.62 APE67-dihe-in -64.58, -17.09 -62.44, -44.52 APE12-dist-out 14.27 APE11-dist-in 10.981 APE10-dist-in 6.789 APE9-dist-in 4.23 None None CME161 XRAY 1.624 0.184 0.232 A 368 338 2 0 0 0 [[25, 313]] 1.0 8ao9 CMGC_MAPK1_HUMAN CMGC 9.9e-86 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK10 MK10_HUMAN 3CGFA P53779 45 400 464.0 JNF:523 Type1 Inactive DFGin 3.719 14.039 ABAminus -89.59, -53.32 -106.99, -179.49 -117.03, 20.53 309.75, 79.33 76.52, -162.79 in-out in 9.602 Saltbr-out 3.611 HRD-in -43.19, -70.09 72.17, 4.64 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -63.93, 178.32 APE9-dihe-na -126.54, 145.54 APE8-dihe-in -86.07, 133.09 APE8-rot-in 307.62 APE67-dihe-in -51.07, -34.7 -123.34, -6.64 APE12-dist-out 21.335 APE11-dist-out 17.893 APE10-dist-out 16.615 APE9-dist-out 11.474 None None None XRAY 3.0 0.225 0.317 A 365 346 5 0 0 5 [[64, 359]] 1.0 3cgf CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 7YL1A P53779 45 400 464.0 J6F:501 Type1 Inactive DFGin 3.995 14.06 ABAminus -80.16, -27.18 -141.36, 174.64 -114.52, 17.98 302.24, 85.17 76.51, -161.32 in-in in 9.23 Saltbr-in 2.755 HRD-in -85.09, -59.15 76.16, -2.31 in-out-out SNCioo out-out ActLoopNT-out 6.441 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -89.31, 134.84 APE9-dihe-na -84.54, 138.55 APE8-dihe-in -77.28, 127.44 APE8-rot-in 291.87 APE67-dihe-in -54.76, -19.99 -106.7, -13.11 APE12-dist-out 20.721 APE11-dist-out 15.877 APE10-dist-out 16.196 APE9-dist-out 11.273 None None None XRAY 2.48 0.208 0.294 A 464 352 2 0 0 2 [[64, 359]] 1.0 7yl1 CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK14 MK14_HUMAN 6ZQSA Q16539 4 353 360.0 3FF:400 Type1 Inactive DFGin 7.131 15.007 BLAminus -100.05, 172.92 58.72, 89.64 -100.69, 26.63 286.71, 76.86 -66.14, -26.38 out-out out 10.282 Saltbr-out 3.92 HRD-in -83.97, -53.39 74.81, 10.18 out-in-in SNCoii in-in ActLoopNT-in 2.855 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.23, 173.02 APE9-dihe-na 73.87, 161.94 APE8-dihe-in -91.46, 139.33 APE8-rot-in 294.96 APE67-dihe-in -66.05, -18.45 -53.95, -45.87 APE12-dist-in 11.599 APE11-dist-in 11.174 APE10-dist-in 6.771 APE9-dist-in 3.046 None TPO180,PTR182 TPO180,PTR182 XRAY 1.95 0.178 0.223 A 362 350 0 0 0 0 [[24, 308]] 1.0 6zqs CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 5XYYA Q16539 4 352 360.0 P0F:401 Type1.5_Back Inactive DFGin 8.144 16.25 BLBminus -111.25, 174.05 61.59, 81.71 -109.03, 145.8 286.82, 89.51 69.26, 21.62 in-in in 8.942 Saltbr-in 2.649 HRD-in -68.14, -52.86 82.9, -10.64 in-out-out SNCioo out-out ActLoopNT-out 11.476 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.86, 131.59 APE9-dihe-na -62.4, -17.36 APE8-dihe-out -62.41, -19.09 APE8-rot-out 53.75 APE67-dihe-in -64.55, -20.22 -114.48, -18.89 APE12-dist-out 21.139 APE11-dist-out 22.895 APE10-dist-out 17.093 APE9-dist-out 11.759 None None None XRAY 1.7 0.18 0.201 A 380 343 6 0 0 0 [[24, 308]] 1.0 5xyy CMGC_MAPK14_HUMAN CMGC 7e-85 290.9 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 2QD9A Q16539 5 352 360.0 LGF:361 Type1 Inactive DFGin 5.134 13.797 BLBplus -108.86, 148.96 74.79, 24.8 -73.05, 150.79 49.54, 82.76 82.07, 6.15 in-in in 9.155 Saltbr-in 2.557 HRD-in -76.06, -55.95 78.8, -20.76 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -59.56, -22.52 999.0, -59.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.252 0.282 A 366 330 18 0 0 13 [[24, 308]] 1.0 2qd9 CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3QUDA Q16539 4 354 360.0 N3F:361 Type1 Inactive DFGin 10.801 12.553 None -93.66, 153.34 -68.51, -47.3 -136.82, 128.38 301.98, 103.1 -95.02, -166.54 in-in in 9.269 Saltbr-in 3.555 HRD-in -63.42, -58.28 80.41, -12.58 in-out-out SNCioo out-out ActLoopNT-out 20.801 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 112.75 APE9-dihe-na -76.37, 136.79 APE8-dihe-out -65.47, -38.0 APE8-rot-in 295.71 APE67-dihe-in -57.05, -26.46 -56.48, -28.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.762 APE9-dist-out 12.652 None None None XRAY 2.0 0.234 0.278 A 360 345 6 0 0 6 [[24, 308]] 1.0 3qud CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3QUEA Q16539 5 353 360.0 3FF:362 Type1 Inactive DFGin 10.642 12.339 None -82.41, 155.86 -75.27, -54.23 -130.98, 134.23 308.77, 88.25 -97.08, -170.31 in-in in 8.96 Saltbr-in 2.657 HRD-in -64.83, -54.13 86.66, -27.06 in-out-out SNCioo out-out ActLoopNT-out 21.279 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 66.84 APE9-dihe-na -77.78, 135.56 APE8-dihe-out -48.89, -54.16 APE8-rot-in 280.74 APE67-dihe-in -53.38, -25.8 -51.95, -34.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.195 APE9-dist-out 11.393 None None None XRAY 2.7 0.23 0.311 A 360 343 6 0 0 6 [[24, 308]] 1.0 3que CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4R3CA Q16539 4 352 360.0 3GF:402,3GF:403 Type1,Allosteric Inactive DFGin 4.924 13.134 None -118.67, 171.2 49.4, 42.48 -86.86, 999.0 38.51, 75.43 999.0, 999.0 in-out in 9.543 Saltbr-out 3.908 HRD-in -66.01, -56.32 81.1, -14.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 103.85 APE9-dihe-na -65.1, 130.86 APE8-dihe-out -51.86, -39.46 APE8-rot-in 289.55 APE67-dihe-in -62.53, -25.36 -48.44, -37.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.264 None None CME162 XRAY 2.06 0.178 0.217 A 383 336 13 0 0 13 [[24, 308]] 1.0 4r3c CMGC_MAPK14_HUMAN CMGC 7.2e-85 290.9 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3L8SA Q16539 4 353 360.0 BFF:361 Type1 Inactive DFGout 15.489 11.977 None -119.54, 162.4 -99.13, -16.66 31.92, 999.0 247.73, 144.9 999.0, 999.0 in-in in 9.497 Saltbr-in 2.817 HRD-in -77.51, -50.13 90.87, -25.05 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 107.11 APE9-dihe-na -94.83, 118.78 APE8-dihe-out -62.16, -3.07 APE8-rot-out 173.18 APE67-dihe-in -59.13, -22.21 -95.45, -15.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.2 C119S,C162S,A172C,F327L None None XRAY 2.35 0.242 0.307 A 360 334 16 0 0 13 [[24, 308]] 1.0 3l8s CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3UVRA Q16539 5 351 360.0 06F:361 Type2 Inactive DFGout 15.561 8.524 None -148.63, 178.6 -133.58, 101.18 -90.01, -1.78 195.55, 17.77 -54.07, 127.45 in-in in 8.211 Saltbr-in 2.627 HRD-in -62.71, -55.49 83.79, -17.62 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -56.89 APE8-dihe-out -51.15, -30.26 APE8-rot-in 300.71 APE67-dihe-in -70.54, -25.21 -93.95, -15.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.621 None None None XRAY 2.1 0.204 0.245 A 360 331 16 0 0 12 [[24, 308]] 1.0 3uvr CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK8 MK08_HUMAN 8PTAA P45983 8 363 427.0 CIF:401 Type1 Inactive DFGin 3.923 14.477 ABAminus -80.58, -61.37 -103.85, 165.38 -100.79, 23.99 295.77, 91.74 73.84, -149.47 in-in in 9.79 Saltbr-in 3.126 HRD-in -78.59, -61.53 62.23, 7.12 in-out-out SNCioo out-out ActLoopNT-out 6.47 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -130.45, 138.38 APE9-dihe-na -101.99, 109.25 APE8-dihe-in -118.89, 112.23 APE8-rot-out 53.5 APE67-dihe-in -51.79, -30.07 -95.29, -17.54 APE12-dist-in 10.569 APE11-dist-out 7.033 APE10-dist-out 10.183 APE9-dist-out 8.598 None None None XRAY 2.41 0.224 0.226 A 366 354 2 0 0 2 [[26, 321]] 1.0 8pta CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 8PTAB P45983 7 363 427.0 CIF:401 Type1 Inactive DFGin 3.577 13.179 ABAminus -81.24, -57.35 -101.3, 158.61 -105.36, 14.2 308.93, 93.28 64.59, -148.13 in-in in 9.366 Saltbr-in 3.536 HRD-in -77.41, -61.25 61.49, 9.23 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -112.33, 168.25 APE9-dihe-na -116.9, 36.67 APE8-dihe-in -104.63, 91.0 APE8-rot-out 52.55 APE67-dihe-in -56.88, -29.41 -95.02, -21.65 APE12-dist-in 11.784 APE11-dist-in 9.152 APE10-dist-out 11.242 APE9-dist-out 10.214 None None None XRAY 2.41 0.224 0.226 B 366 352 5 0 0 5 [[26, 321]] 1.0 8pta CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 8PTAC P45983 8 361 427.0 CIF:401 Type1 Inactive DFGin 3.826 14.088 ABAminus -83.97, -56.35 -97.04, 154.46 -105.76, 13.83 294.99, 32.04 63.79, -147.27 in-out in 9.723 Saltbr-out 4.528 HRD-in -77.01, -60.9 63.25, 7.56 out-out-out SNCooo out-out ActLoopNT-out 4.611 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -137.59 APE9-dihe-na -94.11, 17.64 APE8-dihe-in -81.48, 63.35 APE8-rot-out 71.39 APE67-dihe-in -58.68, -26.77 -108.19, -24.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.467 APE9-dist-out 10.78 None None None XRAY 2.41 0.224 0.226 C 366 351 3 0 0 3 [[26, 321]] 1.0 8pta CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK9 MK09_HUMAN 3E7OA P45984 9 361 424.0 35F:1 Type1 Inactive DFGin 4.266 14.526 ABAminus -84.35, -29.35 -149.55, 177.24 -106.27, 9.79 301.22, 95.14 60.95, -143.01 in-in in 9.439 Saltbr-in 2.686 HRD-in -64.97, -51.12 67.58, -6.1 in-out-out SNCioo out-out ActLoopNT-out 5.519 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -84.71, -45.82 APE9-dihe-na -76.84, -178.43 APE8-dihe-in -88.6, 137.99 APE8-rot-in 266.04 APE67-dihe-out -72.72, -13.34 -138.1, 64.96 APE12-dist-out 20.29 APE11-dist-out 15.686 APE10-dist-out 19.328 APE9-dist-out 14.665 C177S,C222S,K250A,K251A,K265A,K270A None None XRAY 2.14 0.219 0.25 A 360 342 2 0 0 0 [[26, 321]] 1.0 3e7o CMGC_MAPK9_HUMAN CMGC 2.7e-84 288.8 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 9
CMGC MAPK9 MK09_HUMAN 3E7OB P45984 8 362 424.0 35F:2 Type1 Inactive DFGin 4.276 14.318 ABAminus -85.32, -37.61 -133.45, 175.33 -107.39, 15.94 299.45, 88.14 90.36, 999.0 in-in in 9.466 Saltbr-in 2.801 HRD-in -71.07, -57.75 72.11, -12.31 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -39.52 APE8-rot-out 181.64 APE67-dihe-in -65.99, -17.44 -49.19, -35.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C177S,C222S,K250A,K251A,K265A,K270A None None XRAY 2.14 0.219 0.25 B 360 326 19 0 0 16 [[26, 321]] 1.0 3e7o CMGC_MAPK9_HUMAN CMGC 2.7e-84 288.8 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 9
OTHER CDC7 CDC7_HUMAN 6YA8A O00311 38 572 574.0 ADP:60601,BEF:60603 ATPlike,Allosteric None DFGin 6.168 14.087 BLAminus -118.93, 173.08 76.34, 83.66 -102.33, 21.87 291.62, 81.2 -67.07, -22.7 in-in in 8.709 Saltbr-in 2.738 HRD-in -65.76, -44.2 72.35, -4.4 in-in-none SNCiin in-none ActLoopNT-in 2.755 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na -83.06, -154.71 APE8-dihe-in -48.63, 132.1 APE8-rot-in 306.86 APE67-dihe-in -66.07, -7.37 -59.08, -35.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.888 None None None XRAY 1.79 0.167 0.197 A 359 338 13 0 0 13 [[58, 569]] 1.0 6ya8 OTHER_CDC7_HUMAN CMGC 2e-18 137.3 1 161 296 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 375 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER GAK GAK_HUMAN 4C57A O14976 25 334 1311.0 FEF:1340 Type1 Inactive DFGin 5.754 14.141 ABAminus -112.53, -37.31 -102.07, 134.52 -132.21, 22.67 297.88, 98.14 -59.75, -31.11 in-out in 9.993 Saltbr-out 4.057 HRD-in -62.14, -51.36 70.7, -5.09 out-in-in SNCoii in-in ActLoopNT-in 2.895 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.34, 3.52 APE9-dihe-na -124.99, 156.99 APE8-dihe-in -84.98, 122.71 APE8-rot-in 297.75 APE67-dihe-in -71.57, -19.62 -46.23, -44.89 APE12-dist-in 11.779 APE11-dist-in 8.573 APE10-dist-in 4.33 APE9-dist-in 4.07 None None None XRAY 2.55 0.18 0.228 A 340 310 0 0 0 0 [[40, 313]] 1.0 4c57 OTHER_GAK_HUMAN CAMK 5.3e-44 156.7 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 4C57B O14976 27 334 1311.0 FEF:1337 Type1 Inactive DFGin 5.769 14.233 ABAminus -105.07, -37.59 -101.51, 133.86 -130.57, 22.88 297.9, 97.48 -60.27, -26.81 out-out out 10.065 Saltbr-out 4.056 HRD-in -62.14, -52.49 71.3, -9.85 out-in-in SNCoii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.07, 5.67 APE9-dihe-na -124.2, 156.66 APE8-dihe-in -83.72, 121.96 APE8-rot-in 296.0 APE67-dihe-in -71.56, -19.42 -45.7, -45.17 APE12-dist-in 11.928 APE11-dist-in 8.658 APE10-dist-in 4.358 APE9-dist-in 4.086 None None None XRAY 2.55 0.18 0.228 B 340 308 0 0 0 0 [[40, 313]] 1.0 4c57 OTHER_GAK_HUMAN CAMK 5.3e-44 156.7 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 4C59A O14976 27 333 1311.0 FEF:1334 Type1 Inactive DFGin 5.815 13.68 ABAminus -134.62, -10.32 -105.18, 88.43 -107.04, 23.92 300.54, 105.0 -81.95, -10.0 in-in in 9.093 Saltbr-in 2.855 HRD-in -82.36, -54.36 82.63, -15.13 in-in-none SNCiin in-none ActLoopNT-in 2.838 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.205 0.262 A 340 266 41 0 0 27 [[40, 313]] 1.0 4c59 OTHER_GAK_HUMAN CAMK 5.3e-44 156.7 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER HASPIN HASP_HUMAN 9FLTA Q8TF76 471 798 798.0 A1IDF:801 Type1 Active DFGin 5.178 12.218 BLAminus -141.02, 178.95 59.99, 70.73 -81.95, 27.03 316.78, 141.24 -69.29, -28.67 in-in in 8.759 Saltbr-in 2.463 HRD-na-N -66.6, -53.16 75.71, 6.9 in-in-na SNCiia in-na ActLoopNT-in 2.905 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -131.58, 41.34 APE9-dihe-na -102.69, 164.5 APE8-dihe-na -162.68, -171.46 APE8-rot-na 41.52 APE67-dihe-na -134.91, 146.64 100.36, -24.97 APE12-dist-na 9.64 APE11-dist-na 13.509 APE10-dist-na 17.247 APE9-dist-na 13.279 None None None XRAY 2.4 0.187 0.239 A 336 320 8 0 0 0 [[484, 797]] 1.0 9flt OTHER_HASPIN_HUMAN HASP 1.1e-226 756.9 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER TTK TTK_HUMAN 4JS8A P33981 515 793 857.0 1PF:801 Type1 Inactive DFGin 4.246 15.018 ABAminus -84.57, -49.34 -133.98, 167.4 -109.17, 14.51 305.07, 151.28 67.69, 15.63 in-out in 9.993 Saltbr-out 6.699 HRD-in -62.96, -52.34 70.46, -10.5 out-out-out SNCooo out-out ActLoopNT-out 12.036 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnoo APE10-dihe-na 999.0, 112.01 APE9-dihe-na -104.69, -175.56 APE8-dihe-in -119.7, 153.55 APE8-rot-none 999.0 APE67-dihe-in -65.36, -29.34 -115.57, 0.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.198 APE9-dist-out 12.111 None TPO675,TPO686 TPO675,TPO686 XRAY 1.94 0.232 0.253 A 281 261 18 0 0 8 [[525, 791]] 1.0 4js8 OTHER_TTK_HUMAN CAMK 5.6e-54 189.1 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 7CHMA P33981 516 794 857.0 FZF:801 Type1 Inactive DFGin 4.413 14.608 None -111.88, -71.82 -63.89, 158.67 -119.5, 9.1 283.45, 179.72 82.92, -15.75 in-in in 9.56 Saltbr-in 3.396 HRD-in -57.59, -51.23 60.31, 6.24 in-out-out SNCioo out-out ActLoopNT-out 12.264 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, -62.47 APE9-dihe-na 66.11, 172.68 APE8-dihe-out -121.28, -175.85 APE8-rot-none 999.0 APE67-dihe-in -54.56, -33.62 -132.81, 0.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.863 APE9-dist-out 12.904 None TPO675,TPO686 TPO675,TPO686 XRAY 2.65 0.212 0.253 A 281 260 19 0 0 8 [[525, 791]] 1.0 7chm OTHER_TTK_HUMAN CAMK 5.6e-54 189.1 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER ULK1 ULK1_HUMAN 4WNOA O75385 8 280 1050.0 3RF:401 Type1 Active DFGin 6.889 14.949 BLAminus -117.94, 169.26 64.81, 74.6 -94.14, 20.86 282.18, 71.59 -63.55, -24.11 in-in in 7.662 Saltbr-in 2.77 HRD-in -82.57, -51.36 80.06, -2.07 in-in-in SNCiii in-in ActLoopNT-in 2.966 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.03, 162.62 APE9-dihe-na 120.91, -162.5 APE8-dihe-in -119.54, 124.2 APE8-rot-in 305.96 APE67-dihe-in -67.71, -19.19 -53.63, -37.75 APE12-dist-in 8.214 APE11-dist-in 11.212 APE10-dist-in 5.675 APE9-dist-in 3.309 E37A,K38A TPO180 TPO180 XRAY 1.56 0.18 0.208 A 287 273 0 0 0 0 [[14, 278]] 1.0 4wno OTHER_ULK1_HUMAN ULK 2.1e-132 446.2 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
STE MAP2K1 MP2K1_HUMAN 7UMBC Q02750 41 381 393.0 ANP:401,U9F:402 ATPlike,Type3 Inactive DFGin 6.169 13.767 BLBplus -162.24, 171.11 70.21, 49.7 -113.95, 160.88 44.65, 94.08 -79.06, 81.13 out-out out 15.559 Saltbr-out 15.273 HRD-in -66.12, -48.09 76.83, -9.86 out-out-out SNCooo out-out ActLoopNT-out 9.591 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -127.94, 139.36 APE9-dihe-na -138.86, -160.81 APE8-dihe-out -82.2, -18.64 APE8-rot-out 50.9 APE67-dihe-out -106.39, 139.13 -104.8, 110.61 APE12-dist-out 16.699 APE11-dist-out 19.666 APE10-dist-out 21.57 APE9-dist-out 14.915 None None None XRAY 3.231 0.231 0.268 C 384 303 38 0 0 0 [[68, 361]] 1.0 7umb STE_MAP2K1_HUMAN STE 2.3e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K7 MP2K7_HUMAN 6YG3A O14733 103 400 419.0 6HF:60510 Type1 None DFGin 6.195 14.549 BLAminus -146.55, 178.23 54.3, 83.97 -103.73, 30.03 316.89, 91.95 -57.17, -29.89 na-na na 8.345 Saltbr-na 3.36 HRD-in -81.36, -52.29 76.4, 12.98 na-in-none SNCain in-none ActLoopNT-in 2.982 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.05 0.191 0.235 A 307 265 33 0 0 19 [[120, 380]] 1.0 6yg3 STE_MAP2K7_HUMAN STE 2.4e-80 275.5 2 257 256 260 261 262 264 266 149 166 170 240 242 241 243 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
STE MAP4K1 M4K1_HUMAN 8FH4A Q92918 4 293 833.0 XXF:60401 Type1 Inactive DFGin 6.846 14.475 BLAminus -131.99, 171.23 62.34, 86.7 -92.12, 20.1 289.3, 88.42 -59.7, -48.05 in-in in 9.232 Saltbr-in 2.734 HRD-in -67.47, -51.18 67.4, 4.94 in-out-out SNCioo out-out ActLoopNT-out 6.199 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -73.65, -44.57 APE9-dihe-na 76.29, -171.23 APE8-dihe-in -62.48, 141.12 APE8-rot-out 34.25 APE67-dihe-in -59.58, -27.68 -102.29, 0.49 APE12-dist-out 20.304 APE11-dist-out 21.079 APE10-dist-out 21.421 APE9-dist-out 27.259 T165E,S171E None None XRAY 1.827 0.189 0.215 A 331 290 0 0 0 0 [[17, 274]] 1.0 8fh4 STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FH4B Q92918 6 302 833.0 XXF:60402 Type1 Inactive DFGin 6.551 14.294 BLAminus -141.43, 174.43 62.64, 85.33 -93.2, 13.55 285.99, 85.49 -57.34, -45.75 in-in in 8.939 Saltbr-in 2.697 HRD-in -67.85, -50.88 67.73, 2.48 in-out-out SNCioo out-out ActLoopNT-out 6.309 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -67.39, -32.57 APE9-dihe-na 75.42, -167.37 APE8-dihe-in -61.44, 126.8 APE8-rot-out 59.49 APE67-dihe-in -56.24, -30.95 -97.05, -0.91 APE12-dist-out 19.464 APE11-dist-out 20.586 APE10-dist-out 21.665 APE9-dist-out 28.047 T165E,S171E None None XRAY 1.827 0.189 0.215 B 331 297 0 0 0 0 [[17, 274]] 1.0 8fh4 STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FH4C Q92918 1 292 833.0 XXF:60401 Type1 Inactive DFGin 6.824 14.118 BLAminus -136.31, 172.65 64.01, 85.1 -95.02, 19.77 288.84, 83.7 -61.21, -46.39 in-in in 8.967 Saltbr-in 2.733 HRD-in -69.91, -50.19 67.9, 0.86 in-out-out SNCioo out-out ActLoopNT-out 6.08 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -67.7, -68.85 APE9-dihe-na -109.26, -27.15 APE8-dihe-in -115.11, 101.44 APE8-rot-out 62.11 APE67-dihe-in -65.51, -20.35 -96.81, 16.0 APE12-dist-out 19.318 APE11-dist-out 20.935 APE10-dist-out 23.085 APE9-dist-out 28.365 T165E,S171E None None XRAY 1.827 0.189 0.215 C 331 292 0 0 0 0 [[17, 274]] 1.0 8fh4 STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FH4D Q92918 8 292 833.0 XXF:60401 Type1 Inactive DFGin 6.646 14.023 BLAminus -135.73, 170.9 66.66, 83.46 -93.58, 25.1 289.61, 94.72 -69.05, -41.66 in-in in 9.022 Saltbr-in 2.745 HRD-in -74.6, -51.27 71.89, -5.96 in-out-out SNCioo out-out ActLoopNT-out 6.134 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -170.02 APE8-dihe-in -67.05, 131.5 APE8-rot-out 192.16 APE67-dihe-in -57.98, -30.82 -102.78, -3.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 27.427 T165E,S171E None None XRAY 1.827 0.189 0.215 D 331 276 9 0 0 4 [[17, 274]] 1.0 8fh4 STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9QT6A Q92918 6 292 833.0 A1JAF:301 Type1 Inactive DFGin 6.463 13.765 None -60.93, -35.58 -154.04, -176.9 -79.86, 1.42 63.88, 19.01 105.02, -157.57 out-out out 13.28 Saltbr-out 10.782 HRD-in -74.09, -55.53 70.27, 5.38 out-out-out SNCooo out-out ActLoopNT-out 7.582 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -59.89, -40.77 APE9-dihe-na -92.18, -16.28 APE8-dihe-in -142.86, 74.69 APE8-rot-in 316.27 APE67-dihe-in -56.11, -27.62 -91.41, -1.8 APE12-dist-in 9.809 APE11-dist-in 11.134 APE10-dist-out 15.153 APE9-dist-out 12.698 T165E,S171E None None XRAY 1.76 0.198 0.226 A 294 285 2 0 0 0 [[17, 274]] 1.0 9qt6 STE_MAP4K1_HUMAN STE 4.1e-92 314.1 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8CIJA Q92918 14 294 833.0 USF:401 Type1 Inactive DFGout 11.213 7.331 None -112.58, 122.54 -96.1, 115.56 -121.01, 999.0 297.98, 106.95 999.0, 999.0 out-out out 13.535 Saltbr-out 11.8 HRD-in -61.67, -48.53 69.18, 2.25 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na -87.98, 122.06 APE9-dihe-na 145.78, 142.84 APE8-dihe-in -120.8, 116.13 APE8-rot-in 320.07 APE67-dihe-in -58.16, -27.75 -31.5, -57.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.681 None None None XRAY 2.821 0.239 0.266 A 307 264 17 0 0 12 [[17, 274]] 1.0 8cij STE_MAP4K1_HUMAN STE 4.8e-92 313.9 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K4 M4K4_HUMAN 5DI1A O95819 13 309 1239.0 5DF:4000 Type1 Inactive DFGin 4.26 13.366 BLBplus -145.12, 159.02 72.53, 52.2 -89.55, 138.32 48.51, 95.38 -80.62, 999.0 in-out in 9.403 Saltbr-out 3.985 HRD-in -61.2, -47.09 79.65, -23.06 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -102.21, 124.07 APE9-dihe-na -81.57, -147.04 APE8-dihe-in -74.95, 131.45 APE8-rot-out 195.98 APE67-dihe-in -46.35, -33.38 -85.44, -21.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.602 None None None XRAY 2.9 0.2 0.249 A 310 285 12 0 0 12 [[25, 289]] 1.0 5di1 STE_MAP4K4_HUMAN STE 1.3e-102 348.4 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
TKL ACVR1 ACVR1_HUMAN 3MTFA Q04771 203 498 509.0 A3F:1 Type1 Inactive DFGin 7.09 13.208 BLAminus -126.1, 157.67 76.9, 82.69 -86.05, 21.36 306.23, 175.03 -61.66, -24.97 in-out in 8.331 Saltbr-out 4.196 HRD-in -82.54, -58.57 79.29, -1.49 out-in-out SNCoio in-out ActLoopNT-in 2.913 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -103.22, 162.67 APE9-dihe-na -69.88, 165.81 APE8-dihe-in -53.93, 121.99 APE8-rot-in 312.82 APE67-dihe-in -59.42, -28.32 -57.34, -37.41 APE12-dist-in 10.671 APE11-dist-out 6.476 APE10-dist-out 9.482 APE9-dist-in 4.073 Q207D None None XRAY 2.15 0.185 0.244 A 301 296 0 0 0 0 [[207, 497]] 1.0 3mtf TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 3MTFB Q04771 202 499 509.0 A3F:501 Type1 Inactive DFGin 7.578 13.323 BLAminus -114.45, 160.06 82.35, 87.49 -104.83, 25.86 291.12, 164.81 -75.29, -13.54 in-out in 8.5 Saltbr-out 4.232 HRD-in -82.5, -60.12 85.3, -4.39 out-in-out SNCoio in-out ActLoopNT-in 2.869 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -111.75, 153.3 APE9-dihe-na -57.45, 170.81 APE8-dihe-in -65.39, 131.64 APE8-rot-in 306.28 APE67-dihe-in -49.77, -35.33 -68.1, -43.23 APE12-dist-in 10.611 APE11-dist-out 6.453 APE10-dist-out 9.396 APE9-dist-in 4.119 Q207D None None XRAY 2.15 0.185 0.244 B 301 298 0 0 0 0 [[207, 497]] 1.0 3mtf TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 6EIXA Q04771 192 503 509.0 A3F:601 Type1 Inactive DFGin 7.305 13.382 BLAminus -122.31, 163.89 74.01, 85.68 -98.53, 23.31 310.02, 174.96 -66.89, -23.04 in-out in 9.083 Saltbr-out 5.16 HRD-in -81.6, -53.66 78.97, -2.54 out-in-out SNCoio in-out ActLoopNT-in 3.023 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -113.45, 165.41 APE9-dihe-na -59.94, 163.8 APE8-dihe-in -59.76, 126.51 APE8-rot-in 307.55 APE67-dihe-in -58.05, -30.26 -58.58, -41.78 APE12-dist-in 10.589 APE11-dist-out 6.415 APE10-dist-out 9.311 APE9-dist-in 3.871 Q207E None None XRAY 2.3 0.191 0.249 A 340 312 0 0 0 0 [[207, 497]] 1.0 6eix TKL_ACVR1_HUMAN TKL 2.9e-85 292.0 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 8PODA Q04771 172 498 509.0 7IO:60501,F:60502 Type1,Allosteric Inactive DFGin 7.181 13.248 BLAminus -129.23, 172.96 64.95, 88.23 -102.11, 21.22 307.17, 178.99 -69.46, -24.05 in-out in 8.75 Saltbr-out 5.24 HRD-in -77.46, -49.01 73.0, -1.63 out-in-out SNCoio in-out ActLoopNT-in 3.105 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -104.74, 151.99 APE9-dihe-na -69.89, 170.49 APE8-dihe-in -67.7, 124.46 APE8-rot-in 304.29 APE67-dihe-in -63.94, -28.35 -69.6, -32.91 APE12-dist-in 10.74 APE11-dist-out 6.542 APE10-dist-out 9.732 APE9-dist-in 4.647 None None None XRAY 2.59 0.236 0.255 A 330 320 1 0 0 0 [[207, 497]] 1.0 8pod TKL_ACVR1_HUMAN TKL 2.6e-85 292.1 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL BRAF BRAF_HUMAN 4YHTA P15056 449 719 766.0 4EF:61002 Type1 Inactive DFGin 6.44 13.919 BLAminus -130.91, -175.71 59.89, 88.64 -101.88, 16.92 281.61, 73.69 -54.19, -26.07 in-in in 8.608 Saltbr-in 2.731 HRD-in -63.73, -42.35 62.62, 3.64 in-in-out SNCiio in-out ActLoopNT-in 2.881 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -6.83 APE8-dihe-in -100.18, 82.06 APE8-rot-in 287.27 APE67-dihe-in -63.55, -16.06 -74.16, -21.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.11 I543T,I544N,I551T,L706T,L716T None None XRAY 3.05 0.2 0.233 A 272 256 15 0 0 13 [[457, 716]] 1.0 4yht TKL_BRAF_HUMAN TKL 2.7e-84 288.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 4YHTB P15056 449 720 766.0 4EF:60802 Type1 Inactive DFGin 6.405 13.921 BLAminus -128.69, -172.56 54.11, 90.89 -102.92, 13.66 281.86, 71.12 -49.43, -28.96 in-in in 8.583 Saltbr-in 2.701 HRD-in -63.82, -42.99 62.91, 4.22 in-in-out SNCiio in-out ActLoopNT-in 2.864 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -6.59 APE8-dihe-in -97.87, 80.96 APE8-rot-in 285.28 APE67-dihe-in -62.85, -18.47 -75.71, -20.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.034 I543T,I544N,I551T,L706T,L716T None None XRAY 3.05 0.2 0.233 B 272 258 14 0 0 12 [[457, 716]] 1.0 4yht TKL_BRAF_HUMAN TKL 2.7e-84 288.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 3Q96A P15056 449 722 766.0 0NF:1 Type2 Inactive DFGout 12.887 10.676 BBAminus -160.13, -172.44 -118.2, 91.86 -79.01, 12.35 294.04, 84.62 -59.8, 141.31 in-in in 8.392 Saltbr-in 2.855 HRD-in -57.31, -47.78 82.12, -11.82 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -115.71 APE8-rot-in 265.02 APE67-dihe-in -61.58, -24.04 -87.09, -36.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.1 0.233 0.288 A 282 253 21 0 0 18 [[457, 716]] 1.0 3q96 TKL_BRAF_HUMAN TKL 8e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 3Q96B P15056 449 720 766.0 0NF:1 Type2 Inactive DFGout 12.338 11.655 BBAminus -159.06, -168.23 -117.43, 81.54 -79.68, 17.57 296.0, 82.29 -26.83, 105.54 in-in in 8.586 Saltbr-in 3.176 HRD-in -76.92, -42.58 73.28, -12.97 in-out-out SNCioo out-out ActLoopNT-out 18.49 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 159.44 APE8-dihe-in -92.55, 126.53 APE8-rot-in 290.06 APE67-dihe-in -62.77, -20.3 -102.35, -28.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.232 None None None XRAY 3.1 0.233 0.288 B 282 262 10 0 0 10 [[457, 716]] 1.0 3q96 TKL_BRAF_HUMAN TKL 8e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL IRAK4 IRAK4_HUMAN 4YP8A Q9NWZ3 164 459 460.0 4GF:501 Type1 Active DFGin 6.842 14.163 BLAminus -130.64, 178.89 61.7, 76.88 -103.53, 25.67 310.66, 96.36 -67.74, -31.55 in-in in 8.778 Saltbr-in 3.549 HRD-in -57.79, -50.73 76.7, -3.88 in-in-in SNCiii in-in ActLoopNT-in 2.775 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.21, 150.97 APE9-dihe-na 140.01, -173.97 APE8-dihe-in -103.61, 115.43 APE8-rot-in 309.9 APE67-dihe-in -66.28, -16.88 -42.43, -50.13 APE12-dist-in 10.008 APE11-dist-in 11.614 APE10-dist-in 6.326 APE9-dist-in 3.918 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 A 301 287 9 0 0 4 [[183, 456]] 1.0 4yp8 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4YP8B Q9NWZ3 161 459 460.0 4GF:501 Type1 Inactive DFGin 6.917 14.444 BLAminus -129.86, 179.56 60.17, 77.95 -104.22, 26.32 310.53, 95.0 -66.78, -33.18 in-out in 8.685 Saltbr-out 3.962 HRD-in -57.85, -50.75 76.66, -4.15 out-in-in SNCoii in-in ActLoopNT-in 2.853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.74, 150.82 APE9-dihe-na 140.12, -173.75 APE8-dihe-in -103.4, 115.49 APE8-rot-in 310.63 APE67-dihe-in -65.34, -17.03 -41.64, -51.23 APE12-dist-in 10.045 APE11-dist-in 11.581 APE10-dist-in 6.319 APE9-dist-in 3.905 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 B 301 281 18 0 0 6 [[183, 456]] 1.0 4yp8 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4YP8C Q9NWZ3 164 460 460.0 4GF:501 Type1 Inactive DFGin 6.821 14.409 BLAminus -129.81, 179.51 59.35, 79.05 -103.24, 26.6 309.61, 96.69 -66.38, -34.02 in-out in 8.851 Saltbr-out 4.684 HRD-in -59.31, -50.52 77.45, -5.42 out-in-in SNCoii in-in ActLoopNT-in 2.789 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.88, 150.51 APE9-dihe-na 141.79, -174.18 APE8-dihe-in -103.25, 114.63 APE8-rot-in 311.45 APE67-dihe-in -64.61, -17.76 -41.38, -51.75 APE12-dist-in 10.149 APE11-dist-in 11.626 APE10-dist-in 6.34 APE9-dist-in 3.945 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 C 301 290 7 0 0 4 [[183, 456]] 1.0 4yp8 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4YP8D Q9NWZ3 164 459 460.0 4GF:501 Type1 Inactive DFGin 6.854 14.319 BLAminus -129.62, 178.91 61.84, 77.53 -103.67, 26.43 310.15, 95.74 -66.28, -34.21 in-out in 8.915 Saltbr-out 3.802 HRD-in -59.75, -49.91 75.93, -3.95 out-in-in SNCoii in-in ActLoopNT-in 2.79 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.59, 153.02 APE9-dihe-na 138.42, -174.86 APE8-dihe-in -103.4, 114.55 APE8-rot-in 310.75 APE67-dihe-in -64.11, -17.03 -41.21, -51.68 APE12-dist-in 10.015 APE11-dist-in 11.585 APE10-dist-in 6.327 APE9-dist-in 3.922 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 D 301 288 8 0 0 4 [[183, 456]] 1.0 4yp8 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6LXYA Q9NWZ3 163 458 460.0 EXF:501 Type1 Inactive DFGin 6.997 14.049 BLAminus -130.85, 177.02 62.25, 85.69 -105.57, 13.21 307.3, 97.03 -58.17, -30.36 in-out in 8.929 Saltbr-out 5.362 HRD-in -67.47, -54.1 77.02, 0.48 out-in-in SNCoii in-in ActLoopNT-in 2.819 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.95, 147.66 APE9-dihe-na 135.07, -175.38 APE8-dihe-in -106.14, 112.07 APE8-rot-in 312.29 APE67-dihe-in -59.29, -20.88 -52.35, -43.4 APE12-dist-in 10.191 APE11-dist-in 11.704 APE10-dist-in 6.439 APE9-dist-in 4.357 None TPO345,SEP346 TPO345,SEP346 XRAY 2.19 0.202 0.231 A 305 294 2 0 0 2 [[183, 456]] 1.0 6lxy TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6LXYB Q9NWZ3 163 459 460.0 EXF:502 Type1 None DFGin 6.973 14.137 BLAminus -129.45, 177.84 61.74, 86.54 -106.07, 12.43 306.08, 97.48 -57.61, -29.04 in-none in 9.098 Saltbr-none 999.0 HRD-in -68.65, -53.21 75.68, 1.0 none-in-in SNCnii in-in ActLoopNT-in 2.807 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.47, 149.33 APE9-dihe-na 135.3, -175.41 APE8-dihe-in -105.49, 112.4 APE8-rot-in 312.11 APE67-dihe-in -59.55, -21.17 -51.5, -42.55 APE12-dist-in 10.189 APE11-dist-in 11.686 APE10-dist-in 6.444 APE9-dist-in 4.332 None TPO345,SEP346 TPO345,SEP346 XRAY 2.19 0.202 0.231 B 305 297 0 0 0 0 [[183, 456]] 1.0 6lxy TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6LXYD Q9NWZ3 162 459 460.0 EXF:502 Type1 Inactive DFGin 7.002 14.116 BLAminus -130.62, 177.55 62.4, 85.91 -106.35, 12.8 307.19, 98.16 -58.64, -30.18 in-out in 8.943 Saltbr-out 5.354 HRD-in -67.38, -53.42 77.14, -1.48 out-in-in SNCoii in-in ActLoopNT-in 2.786 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.01, 149.8 APE9-dihe-na 134.89, -175.28 APE8-dihe-in -104.95, 111.45 APE8-rot-in 311.34 APE67-dihe-in -58.57, -21.72 -44.58, -48.25 APE12-dist-in 10.314 APE11-dist-in 11.954 APE10-dist-in 6.613 APE9-dist-in 4.254 None TPO345,SEP346 TPO345,SEP346 XRAY 2.19 0.202 0.231 D 305 293 5 0 0 5 [[183, 456]] 1.0 6lxy TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6LXYE Q9NWZ3 164 458 460.0 EXF:502 Type1 Inactive DFGin 6.954 14.159 BLAminus -130.3, 176.57 62.62, 85.73 -105.89, 13.23 306.79, 97.59 -58.45, -29.69 in-out in 8.931 Saltbr-out 5.391 HRD-in -66.96, -52.89 76.03, -0.37 out-in-in SNCoii in-in ActLoopNT-in 2.795 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.25, 150.73 APE9-dihe-na 134.77, -173.9 APE8-dihe-in -105.72, 111.9 APE8-rot-in 311.85 APE67-dihe-in -56.93, -22.86 -45.56, -48.25 APE12-dist-in 10.309 APE11-dist-in 11.905 APE10-dist-in 6.607 APE9-dist-in 4.292 None TPO345,SEP346 TPO345,SEP346 XRAY 2.19 0.202 0.231 E 305 288 7 0 0 7 [[183, 456]] 1.0 6lxy TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL MAP3K12 M3K12_HUMAN 5CEQA Q12852 117 398 859.0 50F:4000 Type1 Inactive DFGin 6.285 14.143 BLBplus -139.34, 175.24 65.23, 33.46 -103.17, 163.52 57.07, 90.2 71.88, 999.0 na-na na 13.937 Saltbr-na 13.245 HRD-in -61.44, -57.14 79.98, -14.5 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -71.43, -48.01 APE9-dihe-na -72.5, -0.08 APE8-dihe-out -118.56, -4.99 APE8-rot-out 184.08 APE67-dihe-in -55.04, -30.89 -63.03, -27.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.132 None None None XRAY 1.911 0.171 0.218 A 300 269 13 0 0 13 [[118, 372]] 1.0 5ceq TKL_MAP3K12_HUMAN MAP3K123 1.5e-137 462.8 1 254 254 253 254 255 257 259 152 161 165 233 235 234 236 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
TKL MAP3K7 M3K7_HUMAN 5J9LA O43318 31 496 606.0 6HF:60501 Type1 Inactive DFGout 12.964 7.575 None -126.7, 106.14 -55.49, -39.75 -39.65, 999.0 105.32, 93.88 999.0, 999.0 in-out in 9.619 Saltbr-out 4.662 HRD-in -64.53, -55.8 74.12, -2.79 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 124.52 APE8-dihe-out -91.5, 21.0 APE8-rot-in 299.75 APE67-dihe-in -63.93, -32.31 -64.12, -36.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7 None None None XRAY 2.752 0.214 0.243 A 307 253 20 0 0 14 [[36, 286]] 1.0 5j9l TKL_MAP3K7_HUMAN TKL 3.7e-74 255.5 2 266 265 174 175 176 178 180 63 77 81 153 155 154 156 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
TKL RIPK1 RIPK1_HUMAN 7FCZA Q13546 10 294 671.0 3IF:301 Type3 Inactive DFGout 13.865 10.379 BBAminus -121.61, 171.92 -133.79, 66.08 -70.41, -22.3 302.99, 177.02 -85.6, 3.29 out-out out 15.002 Saltbr-out 12.85 HRD-in -69.8, -48.63 73.26, -13.72 out-out-out SNCooo out-out ActLoopNT-out 6.074 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 77.72 APE8-dihe-in -67.19, 127.43 APE8-rot-in 294.95 APE67-dihe-in -62.33, -29.47 -101.92, 1.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.476 C34A,C127A,C233A,C240A None None XRAY 2.21 0.236 0.257 A 297 248 37 0 0 18 [[17, 287]] 1.0 7fcz TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 7FCZB Q13546 7 294 671.0 3IF:301 Type3 Inactive DFGout 13.913 10.028 BBAminus -118.21, 174.22 -136.13, 64.53 -68.29, -24.74 303.09, 178.58 -83.09, -0.43 out-out out 14.189 Saltbr-out 12.575 HRD-in -73.47, -53.47 80.61, -17.48 out-out-out SNCooo out-out ActLoopNT-out 6.139 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 101.37 APE8-dihe-in -64.4, 143.44 APE8-rot-out 179.16 APE67-dihe-in -62.08, -29.26 -100.06, -1.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.634 C34A,C127A,C233A,C240A None None XRAY 2.21 0.236 0.257 B 297 263 25 0 0 17 [[17, 287]] 1.0 7fcz TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL TGFBR1 TGFR1_HUMAN 2WOUA P36897 200 496 503.0 ZZF:61500 Type1 Active DFGin 6.124 13.039 BLAminus -133.49, -169.53 51.05, 62.4 -92.04, 13.34 298.31, 178.69 -62.77, -27.98 in-in in 7.586 Saltbr-in 2.752 HRD-in -65.52, -56.03 81.95, -3.97 in-in-in SNCiii in-in ActLoopNT-in 3.039 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -95.77, -22.31 APE9-dihe-na -79.77, -172.15 APE8-dihe-in -73.94, 125.36 APE8-rot-in 306.35 APE67-dihe-in -52.11, -29.79 -56.64, -45.19 APE12-dist-in 13.078 APE11-dist-in 11.935 APE10-dist-in 6.041 APE9-dist-in 3.629 None None None XRAY 2.3 0.229 0.302 A 306 297 0 0 0 0 [[205, 494]] 1.0 2wou TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3 266 264 350 351 352 354 356 232 245 249 330 332 331 333 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 3FAAA P36897 171 500 503.0 55F:601 Type1 Active DFGin 5.904 13.047 BLAminus -165.74, 163.41 74.29, 54.12 -79.67, 24.05 317.06, 176.62 -56.68, -51.28 in-in in 8.001 Saltbr-in 2.936 HRD-in -45.11, -27.8 52.25, 11.68 in-in-in SNCiii in-in ActLoopNT-in 3.111 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.43, -171.19 APE9-dihe-na 80.03, 171.79 APE8-dihe-in -67.98, 121.11 APE8-rot-in 302.91 APE67-dihe-in -99.71, -73.49 -46.09, -5.99 APE12-dist-in 11.624 APE11-dist-in 11.967 APE10-dist-in 6.015 APE9-dist-in 4.061 None None None XRAY 3.35 0.228 0.271 A 342 328 2 0 0 2 [[205, 494]] 1.0 3faa TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3 266 264 350 351 352 354 356 232 245 249 330 332 331 333 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 3FAAB P36897 171 501 503.0 55F:601 Type1 Active DFGin 6.017 13.306 BLAminus -136.45, -176.24 60.04, 54.86 -81.47, 12.98 307.95, 5.19 -52.57, -45.29 in-in in 8.1 Saltbr-in 3.037 HRD-in -75.89, -39.75 60.74, 14.93 in-in-in SNCiii in-in ActLoopNT-in 3.115 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.32, 175.24 APE9-dihe-na 101.52, 166.7 APE8-dihe-in -70.87, 127.35 APE8-rot-in 315.28 APE67-dihe-in -36.34, -44.33 -43.95, -69.54 APE12-dist-in 11.94 APE11-dist-in 12.0 APE10-dist-in 6.373 APE9-dist-in 4.084 None None None XRAY 3.35 0.228 0.271 B 342 324 7 0 0 3 [[205, 494]] 1.0 3faa TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3 266 264 350 351 352 354 356 232 245 249 330 332 331 333 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 3FAAC P36897 171 500 503.0 55F:601 Type1 Inactive DFGin 6.142 13.141 BLAminus -126.27, 176.42 50.71, 78.49 -102.58, 30.06 320.3, 19.34 -66.31, -17.95 in-in in 7.99 Saltbr-in 2.662 HRD-in -67.56, -21.99 46.1, 19.37 in-in-out SNCiio in-out ActLoopNT-in 2.947 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiii APE10-dihe-na -120.66, 131.05 APE9-dihe-na 148.7, 175.0 APE8-dihe-in -102.93, 87.73 APE8-rot-in 305.5 APE67-dihe-out -28.83, -55.82 5.18, -84.04 APE12-dist-in 11.481 APE11-dist-in 12.149 APE10-dist-in 6.247 APE9-dist-in 4.208 None None None XRAY 3.35 0.228 0.271 C 342 330 0 0 0 0 [[205, 494]] 1.0 3faa TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3 266 264 350 351 352 354 356 232 245 249 330 332 331 333 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 3FAAD P36897 171 500 503.0 55F:601 Type1 Active DFGin 6.26 13.168 BLAminus -151.5, 176.63 62.94, 64.2 -90.99, 26.98 302.19, 4.38 -66.56, -19.34 in-in in 7.809 Saltbr-in 2.745 HRD-in -63.44, -55.82 78.14, 1.44 in-in-in SNCiii in-in ActLoopNT-in 2.803 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.86, 174.28 APE9-dihe-na 87.09, 173.14 APE8-dihe-in -66.87, 116.28 APE8-rot-in 325.42 APE67-dihe-in -60.47, -38.15 -48.63, -36.35 APE12-dist-in 11.714 APE11-dist-in 11.894 APE10-dist-in 6.37 APE9-dist-in 4.229 None None None XRAY 3.35 0.228 0.271 D 342 330 0 0 0 0 [[205, 494]] 1.0 3faa TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3 266 264 350 351 352 354 356 232 245 249 330 332 331 333 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 3FAAE P36897 171 500 503.0 55F:601 Type1 Active DFGin 6.355 13.366 BLAminus -131.48, -168.05 37.37, 86.28 -107.7, 26.02 296.92, 176.17 -65.92, -19.56 in-in in 7.781 Saltbr-in 3.095 HRD-in -66.77, -57.93 79.95, 12.98 in-in-in SNCiii in-in ActLoopNT-in 2.85 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.13, 169.87 APE9-dihe-na 90.72, 172.5 APE8-dihe-in -64.72, 129.04 APE8-rot-in 310.98 APE67-dihe-in -56.46, -40.64 -59.57, -42.14 APE12-dist-in 11.99 APE11-dist-in 12.056 APE10-dist-in 6.57 APE9-dist-in 3.982 None None None XRAY 3.35 0.228 0.271 E 342 330 0 0 0 0 [[205, 494]] 1.0 3faa TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3 266 264 350 351 352 354 356 232 245 249 330 332 331 333 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR2 TGFR2_HUMAN 7DV6A P37173 240 543 567.0 HJF:9000 Type1 Active DFGin 7.131 13.432 BLAminus -156.15, -164.95 57.9, 60.45 -93.44, 15.51 294.56, 110.64 -56.6, -36.89 in-in in 7.444 Saltbr-in 2.659 HRD-in -60.78, -51.79 74.77, -4.11 in-in-in SNCiii in-in ActLoopNT-in 2.86 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.14, 141.57 APE9-dihe-na 113.33, -173.4 APE8-dihe-in -82.04, 128.94 APE8-rot-in 303.35 APE67-dihe-in -55.96, -36.36 -60.86, -38.17 APE12-dist-in 11.508 APE11-dist-in 11.89 APE10-dist-in 6.046 APE9-dist-in 3.912 E431A,R433A,E485A,K488A,R493A,R495A None None XRAY 2.39 0.163 0.224 A 323 304 0 0 0 0 [[244, 540]] 1.0 7dv6 TKL_TGFBR2_HUMAN TKL 2.1e-77 266.2 2 266 265 396 397 398 400 402 277 290 294 376 378 377 379 446 428 423 422 421 420 419 418 417 326 TGF-beta receptor type-2
TYR ALK ALK_HUMAN 4CCUA Q9UM73 1093 1402 1620.0 AWF:1500 Type1 Inactive DFGin 6.02 14.623 ABAminus -118.73, -9.8 -132.17, 139.04 -133.56, 37.48 295.42, 86.35 -74.53, -27.89 in-out in 8.277 Saltbr-out 4.689 HRD-in -77.94, -47.73 82.62, -10.67 out-out-out SNCooo out-out ActLoopNT-out 6.803 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.98, -27.23 APE9-dihe-in -56.62, 135.11 APE8-dihe-in -75.38, 65.75 APE8-rot-na 29.29 APE67-dihe-in -70.29, -14.23 -60.1, -29.45 APE12-dist-na 14.525 APE11-dist-na 15.17 APE10-dist-na 10.028 APE9-dist-in 7.796 None None None XRAY 2.0 0.202 0.233 A 327 293 17 0 0 6 [[1116, 1385]] 1.0 4ccu TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 4FNZA Q9UM73 1093 1402 1620.0 NZF:1501 Type1 Inactive DFGin 5.291 12.8 ABAminus -135.46, 12.02 -152.76, 153.63 -83.97, -38.55 283.31, 122.35 73.66, 999.0 in-in in 8.5 Saltbr-in 2.812 HRD-in -72.66, -49.3 78.9, -9.45 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -97.65, -24.93 APE9-dihe-in -50.61, 132.71 APE8-dihe-in -79.34, 69.48 APE8-rot-na 27.73 APE67-dihe-in -74.42, -13.21 -56.44, -36.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.83 C1097S None None XRAY 2.6 0.202 0.261 A 327 287 23 0 0 15 [[1116, 1385]] 1.0 4fnz TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 4DCEA Q9UM73 1093 1402 1620.0 0JF:1501 Type1 Inactive DFGin 5.63 13.823 None -137.27, 16.47 -161.52, 152.14 -94.73, 164.26 291.72, 122.64 -76.17, 999.0 in-in in 8.482 Saltbr-in 2.883 HRD-in -75.4, -48.78 85.77, -10.33 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -96.83, -20.84 APE9-dihe-in -55.51, 136.7 APE8-dihe-in -77.28, 70.08 APE8-rot-na 28.6 APE67-dihe-in -68.31, -8.92 -56.77, -41.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.974 C1097S None None XRAY 2.03 0.211 0.256 A 333 288 22 0 0 14 [[1116, 1385]] 1.0 4dce TYR_ALK_HUMAN TYR 1.5e-90 309.0 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 4DCEB Q9UM73 1094 1402 1620.0 0JF:1501 Type1 Inactive DFGin 5.747 13.628 None -141.04, 18.73 -165.26, 150.02 -96.5, 167.37 286.77, 120.17 -70.38, 999.0 in-in in 8.563 Saltbr-in 2.99 HRD-in -72.56, -48.26 83.87, -14.3 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -96.41, -12.56 APE9-dihe-in -59.98, 136.0 APE8-dihe-in -80.48, 64.18 APE8-rot-na 31.8 APE67-dihe-in -66.1, -14.3 -52.07, -41.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.713 C1097S None None XRAY 2.03 0.211 0.256 B 333 284 25 0 0 15 [[1116, 1385]] 1.0 4dce TYR_ALK_HUMAN TYR 1.5e-90 309.0 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR BTK BTK_HUMAN 5FBNC Q06187 395 658 659.0 5WF:701,5WE:702 Type1.5_Front,Allosteric Inactive DFGin 6.234 13.485 BLBplus -138.97, 172.93 64.41, 21.2 -64.91, 134.85 43.34, 89.93 78.28, -17.1 out-out out 15.007 Saltbr-out 15.714 HRD-in -67.81, -54.89 86.66, -24.42 out-out-out SNCooo out-out ActLoopNT-out 8.194 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out 143.31, -31.01 APE9-dihe-in -63.12, 135.49 APE8-dihe-in -76.38, 65.1 APE8-rot-na 32.35 APE67-dihe-in -72.98, -10.12 -50.46, -47.16 APE12-dist-na 999.0 APE11-dist-na 17.831 APE10-dist-na 12.608 APE9-dist-out 8.181 None None None XRAY 1.8 0.182 0.226 C 271 256 8 0 0 8 [[402, 653]] 1.0 5fbn TYR_BTK_HUMAN TYR 6e-93 316.8 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 5FBND Q06187 394 658 659.0 5WF:702,5WE:703,5WE:704,5WE:705 Type1.5_Front,Allosteric,Allosteric,Allosteric Inactive DFGin 6.25 13.472 BLBplus -137.76, 172.64 65.66, 19.16 -62.24, 135.48 45.56, 88.91 74.32, -16.76 out-out out 15.056 Saltbr-out 15.752 HRD-in -65.32, -54.88 86.04, -26.38 out-out-none SNCoon out-none ActLoopNT-out 8.195 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.18 APE8-dihe-in -78.24, 64.6 APE8-rot-na 31.95 APE67-dihe-in -74.36, -8.3 -50.81, -46.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.898 None None None XRAY 1.8 0.182 0.226 D 271 255 10 0 0 10 [[402, 653]] 1.0 5fbn TYR_BTK_HUMAN TYR 6e-93 316.8 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR DDR1 DDR1_HUMAN 5SAUA Q08345 604 912 913.0 1IF:61000 Type2 Inactive DFGout 12.628 9.672 BBAminus -137.39, -170.54 -153.95, 108.1 -100.48, 5.9 289.81, 101.12 83.39, -174.73 in-in in 8.355 Saltbr-in 2.869 HRD-in -71.66, -48.67 82.15, -10.52 in-out-in SNCioi out-in ActLoopNT-out 18.139 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.56, 139.94 APE9-dihe-in -129.66, 123.98 APE8-dihe-in -80.56, 70.77 APE8-rot-na 35.49 APE67-dihe-in -73.85, -9.33 -63.13, -31.85 APE12-dist-na 13.331 APE11-dist-na 10.312 APE10-dist-na 5.884 APE9-dist-in 7.555 None None None XRAY 1.8 0.201 0.231 A 321 287 16 0 0 0 [[610, 907]] 1.0 5sau TYR_DDR1_HUMAN TYR 1.4e-92 315.7 1 260 260 783 784 785 787 789 655 672 676 763 765 764 766 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR EPHA2 EPHA2_HUMAN 8BOCA P29317 605 888 976.0 QUF:1001 Type2 Inactive DFGout 13.583 10.813 BBAminus -139.62, -179.28 -151.24, 106.28 -78.98, -6.2 302.64, 171.21 84.05, 5.79 in-in in 8.869 Saltbr-in 3.501 HRD-in -70.68, -54.7 83.35, -19.69 in-out-in SNCioi out-in ActLoopNT-out 12.248 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.53, 160.37 APE9-dihe-in -116.01, 148.45 APE8-dihe-in -79.02, 97.78 APE8-rot-na 34.23 APE67-dihe-in -77.84, -8.8 -56.96, -40.4 APE12-dist-na 12.844 APE11-dist-na 9.325 APE10-dist-na 7.892 APE9-dist-in 5.837 None None None XRAY 1.9 0.248 0.286 A 306 271 13 0 0 0 [[613, 873]] 1.0 8boc TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHB4 EPHB4_HUMAN 2X9FA P54760 608 888 987.0 X9F:1889 Type1 Inactive DFGin 6.208 14.33 BLBminus -134.1, -172.08 65.01, 71.96 -106.66, 162.22 301.36, 107.12 163.16, 158.85 in-in in 7.543 Saltbr-in 2.703 HRD-in -73.92, -48.13 77.71, -16.54 in-out-in SNCioi out-in ActLoopNT-out 9.79 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.56, 149.08 APE9-dihe-in -55.67, 129.32 APE8-dihe-in -83.14, 89.74 APE8-rot-na 29.6 APE67-dihe-in -62.34, -22.56 -52.45, -48.78 APE12-dist-na 8.363 APE11-dist-na 11.417 APE10-dist-na 15.416 APE9-dist-in 6.34 Y774E None None XRAY 1.75 0.159 0.194 A 302 265 16 0 0 13 [[615, 876]] 1.0 2x9f TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR FGFR1 FGFR1_HUMAN 9UHIA P11362 458 764 822.0 A1EPF:60801 Type1 Inactive DFGin 5.058 13.436 BLAplus -111.91, 163.26 62.65, 26.85 -80.22, -19.74 58.59, 88.0 -94.12, 4.52 in-in in 8.251 Saltbr-in 2.888 HRD-in -74.14, -50.3 78.02, -11.1 in-out-out SNCioo out-out ActLoopNT-out 7.511 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -88.77, 149.44 APE9-dihe-in -108.01, 98.39 APE8-dihe-out -63.46, -15.87 APE8-rot-na 3.35 APE67-dihe-in -71.69, -10.38 -55.45, -26.93 APE12-dist-na 17.216 APE11-dist-na 19.672 APE10-dist-na 16.685 APE9-dist-out 11.083 None None None XRAY 1.76 0.163 0.197 A 310 307 0 0 0 0 [[478, 756]] 1.0 9uhi TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 9UHIB P11362 458 763 822.0 A1EPF:60801 Type1 Inactive DFGin 5.213 12.738 BLAplus -108.15, 164.77 66.41, 24.28 -84.34, -17.16 58.96, 83.83 -89.87, -8.4 in-in in 7.768 Saltbr-in 3.449 HRD-in -77.39, -52.67 76.89, -15.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -74.45, 132.66 APE9-dihe-in -102.74, 93.19 APE8-dihe-out -60.68, -21.29 APE8-rot-na 332.28 APE67-dihe-in -72.11, -2.38 -56.87, -27.58 APE12-dist-na 17.352 APE11-dist-na 20.682 APE10-dist-na 16.965 APE9-dist-out 11.364 None None None XRAY 1.76 0.163 0.197 B 310 286 20 0 0 7 [[478, 756]] 1.0 9uhi TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 3C4FA P11362 464 765 822.0 C4F:1 Type1.5_Back Inactive DFGin 5.114 13.318 BLAplus -110.44, 159.78 58.59, 34.58 -81.02, -11.31 51.22, 81.2 -119.48, 23.64 in-out in 7.866 Saltbr-out 4.632 HRD-in -67.82, -57.48 84.79, -17.47 out-out-out SNCooo out-out ActLoopNT-out 9.069 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -97.31, 173.6 APE9-dihe-in -111.71, 110.92 APE8-dihe-out -49.57, -28.9 APE8-rot-na 335.93 APE67-dihe-in -76.49, -6.67 -57.78, -16.15 APE12-dist-na 19.292 APE11-dist-na 21.121 APE10-dist-na 19.395 APE9-dist-out 11.757 C488A None None XRAY 2.07 0.213 0.264 A 302 290 12 0 0 0 [[478, 756]] 1.0 3c4f TYR_FGFR1_HUMAN TYR 1.3e-104 355.0 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 3C4FB P11362 464 765 822.0 C4F:2 Type1.5_Back Inactive DFGin 5.186 13.096 BLAplus -113.87, 161.2 54.21, 44.76 -88.95, -14.38 49.14, 89.01 -114.94, 24.21 in-in in 7.831 Saltbr-in 3.248 HRD-in -69.91, -54.09 86.4, -33.67 in-out-out SNCioo out-out ActLoopNT-out 8.934 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.54, 164.12 APE9-dihe-in -103.97, 111.75 APE8-dihe-out -49.46, -30.24 APE8-rot-na 330.07 APE67-dihe-in -74.8, -7.14 -56.82, -17.81 APE12-dist-na 19.37 APE11-dist-na 21.296 APE10-dist-na 19.671 APE9-dist-out 11.643 C488A None None XRAY 2.07 0.213 0.264 B 302 290 12 0 0 0 [[478, 756]] 1.0 3c4f TYR_FGFR1_HUMAN TYR 1.3e-104 355.0 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 5EW8A P11362 464 765 822.0 5SF:803 Type1.5_Back Inactive DFGin 4.948 13.265 BLAplus -106.94, 161.6 53.73, 34.99 -75.93, -13.84 56.0, 83.89 -112.21, 7.75 in-in in 7.954 Saltbr-in 2.801 HRD-in -68.23, -51.53 79.48, -14.26 in-out-out SNCioo out-out ActLoopNT-out 9.067 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.87, 162.8 APE9-dihe-in -100.01, 112.78 APE8-dihe-out -57.6, -21.18 APE8-rot-na 333.77 APE67-dihe-in -70.4, -6.07 -56.33, -25.26 APE12-dist-na 19.37 APE11-dist-na 20.743 APE10-dist-na 19.216 APE9-dist-out 11.882 None None None XRAY 1.63 0.186 0.206 A 309 291 11 0 0 0 [[478, 756]] 1.0 5ew8 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 5EW8B P11362 461 765 822.0 5SF:802 Type1.5_Back Inactive DFGin 5.002 13.124 BLAplus -109.75, 160.16 55.05, 34.73 -78.35, -12.87 54.65, 85.31 -106.64, 12.94 in-in in 7.88 Saltbr-in 2.807 HRD-in -67.52, -52.32 78.89, -12.97 in-out-out SNCioo out-out ActLoopNT-out 8.38 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.81, 162.42 APE9-dihe-in -99.2, 111.94 APE8-dihe-out -57.42, -21.49 APE8-rot-na 334.53 APE67-dihe-in -69.99, -6.88 -56.65, -24.13 APE12-dist-na 19.902 APE11-dist-na 21.169 APE10-dist-na 19.654 APE9-dist-out 11.767 None None None XRAY 1.63 0.186 0.206 B 309 290 15 0 0 2 [[478, 756]] 1.0 5ew8 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 7WCLA P11362 459 764 822.0 8ZF:60801 Type1.5_Back Inactive DFGin 5.032 13.511 BLAplus -110.65, 158.43 54.71, 42.71 -89.1, -11.93 53.54, 87.56 -114.63, 26.86 in-in in 8.234 Saltbr-in 2.943 HRD-in -65.51, -45.04 70.13, -0.28 in-out-out SNCioo out-out ActLoopNT-out 7.98 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -98.05, 142.67 APE9-dihe-in -99.82, 98.85 APE8-dihe-out -66.04, -10.56 APE8-rot-na 23.45 APE67-dihe-in -75.78, -2.11 -60.96, -29.19 APE12-dist-na 16.725 APE11-dist-na 19.067 APE10-dist-na 16.226 APE9-dist-out 11.223 C584S None None XRAY 2.495 0.195 0.23 A 310 306 0 0 0 0 [[478, 756]] 1.0 7wcl TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 7WCLB P11362 458 763 822.0 8ZF:60801 Type1.5_Back Inactive DFGin 5.686 13.297 BLAplus -116.0, 164.36 53.53, 38.11 -89.51, -19.74 50.41, 88.95 -102.65, 11.92 in-in in 8.381 Saltbr-in 2.804 HRD-in -77.55, -44.61 69.5, -1.67 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -124.03, 166.88 APE9-dihe-in -112.63, 116.79 APE8-dihe-out -58.21, -18.36 APE8-rot-na 340.54 APE67-dihe-in -81.23, 2.92 -65.55, -20.31 APE12-dist-na 18.6 APE11-dist-na 21.605 APE10-dist-na 19.498 APE9-dist-out 11.402 C584S None None XRAY 2.495 0.195 0.23 B 310 285 21 0 0 8 [[478, 756]] 1.0 7wcl TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR3 FGFR3_HUMAN 8UDTA P22607 457 756 806.0 MLT:61001,MLT:61002,WGF:61003 Allosteric,Allosteric,Type1.5_Front Inactive DFGin 5.441 13.493 BLAplus -114.8, 158.79 55.69, 43.2 -82.19, -34.37 42.84, 89.08 -83.27, -4.41 in-out in 8.383 Saltbr-out 5.287 HRD-in -68.34, -46.54 75.89, -9.4 out-out-out SNCooo out-out ActLoopNT-out 7.921 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 112.29 APE8-dihe-out -63.06, -32.23 APE8-rot-na 340.92 APE67-dihe-in -68.35, -26.42 -62.13, -28.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.198 P572S,P573G None None XRAY 2.829 0.263 0.274 A 297 284 4 0 0 4 [[472, 750]] 1.0 8udt TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 8UDTB P22607 457 754 806.0 WGF:62001 Type1.5_Front Inactive DFGin 5.258 13.71 BLAplus -108.64, 157.87 56.15, 40.62 -79.39, -35.54 45.72, 88.06 -80.67, 0.1 in-out in 8.445 Saltbr-out 5.398 HRD-in -67.98, -43.8 74.91, -8.8 out-out-out SNCooo out-out ActLoopNT-out 7.867 ActLoopCT-out TYR APEdihe_nooai APEdist_aaao APE10-dihe-none 999.0, -64.67 APE9-dihe-out -68.82, -39.67 APE8-dihe-out -56.45, -17.85 APE8-rot-na 337.42 APE67-dihe-in -61.76, -27.35 -59.02, -40.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.666 APE9-dist-out 10.854 P572S,P573G None None XRAY 2.829 0.263 0.274 B 297 283 3 0 0 3 [[472, 750]] 1.0 8udt TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 8UDTC P22607 457 756 806.0 WGF:62001 Type1.5_Front Inactive DFGin 5.258 13.824 BLAplus -109.74, 157.08 55.91, 40.67 -78.94, -35.79 45.97, 87.77 -81.04, -4.46 in-out in 8.545 Saltbr-out 4.103 HRD-in -68.09, -46.3 75.11, -4.3 out-out-out SNCooo out-out ActLoopNT-out 7.87 ActLoopCT-out TYR APEdihe_nooai APEdist_aaao APE10-dihe-none 999.0, -150.08 APE9-dihe-out -67.3, -42.56 APE8-dihe-out -46.98, -31.66 APE8-rot-na 333.46 APE67-dihe-in -60.08, -29.46 -58.03, -43.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.405 APE9-dist-out 11.049 P572S,P573G None None XRAY 2.829 0.263 0.274 C 297 284 4 0 0 4 [[472, 750]] 1.0 8udt TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR4 FGFR4_HUMAN 7WCXA P22455 453 752 802.0 90F:801 Type1 Inactive DFGin 5.263 13.141 BLAplus -114.81, 160.0 54.39, 48.08 -89.68, -16.38 44.55, 83.39 -109.65, 26.27 in-in in 7.792 Saltbr-in 2.511 HRD-in -76.2, -43.73 72.01, -8.39 in-out-out SNCioo out-out ActLoopNT-out 8.644 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -80.24, 137.24 APE9-dihe-in -109.54, 93.42 APE8-dihe-out -57.65, -19.77 APE8-rot-na 335.57 APE67-dihe-in -71.93, -5.42 -64.19, -25.82 APE12-dist-na 19.074 APE11-dist-na 20.85 APE10-dist-na 16.822 APE9-dist-out 11.904 C477A,R664E None None XRAY 2.175 0.173 0.221 A 309 300 0 0 0 0 [[467, 745]] 1.0 7wcx TYR_FGFR4_HUMAN TYR 7e-101 342.8 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 7WCWA P22455 453 752 802.0 90F:801 Type1 Inactive DFGin 5.839 13.063 BLAplus -123.48, 161.59 54.95, 50.1 -96.76, -24.53 39.59, 83.16 -101.63, 31.89 in-in in 7.582 Saltbr-in 3.4 HRD-in -77.43, -45.16 72.65, -7.54 in-out-out SNCioo out-out ActLoopNT-out 8.633 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -81.49, 135.61 APE9-dihe-in -107.87, 94.77 APE8-dihe-out -59.45, -18.22 APE8-rot-na 336.81 APE67-dihe-in -74.15, -1.22 -67.3, -23.03 APE12-dist-na 19.435 APE11-dist-na 20.996 APE10-dist-na 16.929 APE9-dist-out 11.84 C477A,R664E None None XRAY 2.317 0.179 0.221 A 309 300 0 0 0 0 [[467, 745]] 1.0 7wcw TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 6JPJA P22455 454 752 802.0 FGF:800 Type1 Inactive DFGin 5.301 12.658 BLAplus -117.71, 161.57 53.08, 42.72 -89.02, -4.4 50.47, 87.12 -117.52, 24.43 in-in in 7.247 Saltbr-in 2.318 HRD-out -71.89, 98.16 -78.45, 15.53 in-out-out SNCioo out-out ActLoopNT-out 8.002 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -85.03, 139.81 APE9-dihe-in -112.83, 87.62 APE8-dihe-out -50.76, -19.28 APE8-rot-na 332.54 APE67-dihe-in -80.03, 5.83 -68.35, -18.64 APE12-dist-na 19.294 APE11-dist-na 21.068 APE10-dist-na 17.129 APE9-dist-out 12.054 C477A,R664E None None XRAY 2.638 0.198 0.243 A 311 299 0 0 0 0 [[467, 745]] 1.0 6jpj TYR_FGFR4_HUMAN TYR 1.3e-100 341.9 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 7VJLA P22455 454 753 802.0 7IF:801 Type1 Inactive DFGin 5.301 12.42 BLAplus -114.78, 170.3 57.71, 40.42 -94.32, 21.48 55.77, 90.38 -107.29, 999.0 in-in in 7.485 Saltbr-in 2.904 HRD-out -79.19, -58.83 -98.34, 2.36 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 2.26 APE8-rot-na 31.94 APE67-dihe-in -59.38, -20.97 -56.11, -39.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.212 0.273 A 301 263 37 0 0 19 [[467, 745]] 1.0 7vjl TYR_FGFR4_HUMAN TYR 1.1e-100 342.2 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 7VJLB P22455 453 753 802.0 7IF:801 Type1 Inactive DFGin 5.405 13.204 BLAplus -123.58, 175.88 60.77, 35.86 -95.6, 5.83 48.51, 81.65 -122.94, 999.0 in-in in 7.876 Saltbr-in 2.665 HRD-out -72.76, -57.66 -103.85, -18.8 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 6.57 APE8-rot-na 30.25 APE67-dihe-in -55.58, -34.43 -70.09, -36.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.212 0.273 B 301 266 35 0 0 19 [[467, 745]] 1.0 7vjl TYR_FGFR4_HUMAN TYR 1.1e-100 342.2 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 6YI8A P22455 453 753 802.0 FGF:801 Type1 Inactive DFGin 5.052 12.585 BLAplus -114.37, 162.1 61.01, 37.7 -86.22, -22.44 57.75, 86.82 -88.83, -1.63 in-in in 7.21 Saltbr-in 2.807 HRD-in -68.35, -54.97 79.66, -18.38 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 137.99 APE9-dihe-in -91.08, 144.79 APE8-dihe-in -80.88, 56.75 APE8-rot-na 32.63 APE67-dihe-in -69.74, -13.54 -50.67, -37.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 19.129 APE9-dist-out 9.562 None None None XRAY 2.13 0.198 0.231 A 307 277 24 0 0 15 [[467, 745]] 1.0 6yi8 TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 6YI8B P22455 451 752 802.0 FGF:801 Type1 Inactive DFGin 5.551 13.074 BLAplus -114.83, 168.14 49.73, 54.77 -99.35, -32.03 46.0, 89.99 -71.98, 999.0 in-in in 7.399 Saltbr-in 2.814 HRD-in -67.69, -51.4 79.31, -36.01 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.49 APE8-dihe-in -88.73, 63.1 APE8-rot-na 25.93 APE67-dihe-in -70.74, -12.22 -53.82, -35.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.081 None None None XRAY 2.13 0.198 0.231 B 307 270 32 0 0 18 [[467, 745]] 1.0 6yi8 TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 7WCTA P22455 453 752 802.0 90F:801 Type1 Inactive DFGin 5.499 13.008 BLAplus -115.75, 158.15 54.59, 44.67 -82.33, -22.35 42.51, 87.35 -106.03, 33.12 in-in in 7.476 Saltbr-in 2.881 HRD-in -76.31, -44.07 70.33, -3.05 in-out-out SNCioo out-out ActLoopNT-out 8.497 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -84.18, 139.68 APE9-dihe-in -111.32, 93.14 APE8-dihe-out -55.09, -20.87 APE8-rot-na 333.3 APE67-dihe-in -74.74, -3.5 -65.15, -23.14 APE12-dist-na 19.463 APE11-dist-na 21.045 APE10-dist-na 17.074 APE9-dist-out 11.772 R664E None None XRAY 2.106 0.184 0.217 A 311 300 0 0 0 0 [[467, 745]] 1.0 7wct TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 5XFJA P22455 453 750 802.0 6LF:801 Type1 Inactive DFGin 5.021 13.251 None -115.6, 133.16 70.83, 138.96 -157.69, 175.22 19.16, 82.91 -161.9, 174.05 in-out in 8.31 Saltbr-out 4.274 HRD-out -142.96, 112.57 -85.34, -51.29 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -47.84 APE8-dihe-in -93.04, 75.41 APE8-rot-na 34.31 APE67-dihe-in -59.81, -17.88 -81.83, -32.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.229 V550M None None XRAY 3.25 0.284 0.336 A 311 266 32 0 0 17 [[467, 745]] 1.0 5xfj TYR_FGFR4_HUMAN TYR 4.5e-101 343.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 5XFFA P22455 453 750 802.0 6LF:801 Type1 Inactive DFGin 7.251 13.8 None -91.81, 157.14 71.12, 141.83 -151.53, 140.75 303.34, 100.5 -174.03, 158.26 in-in in 7.907 Saltbr-in 3.562 HRD-out -144.83, 101.6 -75.14, -41.6 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -18.13 APE8-dihe-in -83.47, 67.75 APE8-rot-na 31.32 APE67-dihe-in -75.73, 1.3 -73.66, -27.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.541 V550L None None XRAY 2.7 0.27 0.32 A 311 269 29 0 0 17 [[467, 745]] 1.0 5xff TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 5JKGA P22455 453 750 802.0 6LF:801 Type1 Inactive DFGin 4.645 13.415 None -80.35, 138.57 42.13, 154.03 -151.26, -44.79 29.5, 89.83 59.57, 154.84 in-in in 7.788 Saltbr-in 2.748 HRD-out -157.35, 80.6 -45.38, -51.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -51.98 APE8-dihe-in -77.75, 74.49 APE8-rot-na 28.85 APE67-dihe-in -78.7, 0.61 -72.33, -28.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.405 None None None XRAY 2.352 0.237 0.277 A 311 266 32 0 0 17 [[467, 745]] 1.0 5jkg TYR_FGFR4_HUMAN TYR 8.4e-101 342.6 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FLT3 FLT3_HUMAN 6JQRA P36888 571 951 993.0 C6F:1001 Type1 Inactive DFGout 15.394 10.885 None -119.73, 157.71 -104.23, 115.68 77.2, 999.0 255.94, 91.42 999.0, 999.0 in-in in 8.326 Saltbr-in 2.804 HRD-out -98.26, 117.82 -85.48, 11.47 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -131.05, 100.76 APE9-dihe-in -103.87, 123.04 APE8-dihe-in -78.74, 70.62 APE8-rot-na 34.5 APE67-dihe-in -69.1, -11.06 -54.04, -46.43 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.223 None None None XRAY 2.2 0.181 0.213 A 330 301 29 0 0 6 [[610, 945]] 1.0 6jqr TYR_FLT3_HUMAN TYR 8.5e-103 349.1 1 259 259 828 829 830 832 834 644 661 665 808 810 809 811 870 858 853 852 851 850 849 848 847 692 Receptor-type tyrosine-protein kinase FLT3
TYR HCK HCK_HUMAN 3VS4A P08631 81 526 526.0 VSF:60603 Type1.5_Back Inactive DFGin 5.296 12.617 BLBplus -129.05, 156.5 78.18, 7.28 -55.31, 122.08 48.34, 94.72 91.65, -36.18 out-out out 13.53 Saltbr-out 14.391 HRD-in -89.51, -57.9 84.08, -11.13 out-out-out SNCooo out-out ActLoopNT-out 6.875 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 47.3 APE8-dihe-in -93.7, 67.91 APE8-rot-na 28.82 APE67-dihe-in -68.45, -16.47 -64.44, -22.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.697 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.747 0.265 0.265 A 454 429 11 0 0 11 [[262, 513]] 1.0 3vs4 TYR_HCK_HUMAN TYR 1.4e-95 325.6 1 260 260 398 399 400 402 404 290 305 309 378 380 379 381 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 3VS4B P08631 81 526 526.0 VSF:60603 Type1.5_Back Inactive DFGin 5.285 12.665 BLBplus -120.89, 167.83 61.49, 15.86 -62.02, 121.53 47.24, 95.4 75.03, 10.7 out-out out 13.766 Saltbr-out 15.042 HRD-in -94.45, -46.27 74.87, -7.2 out-out-out SNCooo out-out ActLoopNT-out 7.135 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 48.23 APE8-dihe-in -84.31, 74.96 APE8-rot-na 34.0 APE67-dihe-in -71.24, -2.76 -88.69, -13.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.595 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.747 0.265 0.265 B 454 434 12 0 0 12 [[262, 513]] 1.0 3vs4 TYR_HCK_HUMAN TYR 1.4e-95 325.6 1 260 260 398 399 400 402 404 290 305 309 378 380 379 381 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR JAK2-1 JAK2_HUMAN 8B9EA O60674 536 809 1132.0 Q7F:1003 Type1 Pseudo DFGin 5.769 13.226 None -72.27, 175.04 -67.31, 162.54 -76.41, -26.42 340.6, 33.67 78.05, -163.23 out-na out 11.726 Saltbr-na 999.0 HRD-in -83.9, -60.17 88.41, -6.41 na-out-out SNCaoo out-out ActLoopNT-out 8.95 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.18, -39.02 APE9-dihe-out -59.74, -28.13 APE8-dihe-out -86.36, 6.28 APE8-rot-na 284.57 APE67-dihe-out -105.41, 26.85 -68.63, 134.78 APE12-dist-na 9.613 APE11-dist-na 11.316 APE10-dist-na 15.854 APE9-dist-out 12.106 W777A,F794H None None XRAY 1.5 0.17 0.194 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8b9e TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B9HA O60674 536 809 1132.0 Q7F:901 Type1 Pseudo DFGin 6.01 13.307 None -84.93, -177.89 -74.12, 157.3 -67.76, -31.57 343.4, 32.07 81.26, -168.8 out-na out 12.097 Saltbr-na 999.0 HRD-in -82.25, -60.3 91.76, -5.32 na-out-out SNCaoo out-out ActLoopNT-out 9.143 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.85, -39.85 APE9-dihe-out -62.27, -26.85 APE8-dihe-out -86.04, 1.76 APE8-rot-na 292.25 APE67-dihe-out -100.68, 23.58 -62.84, 136.16 APE12-dist-na 9.712 APE11-dist-na 11.434 APE10-dist-na 15.933 APE9-dist-out 12.428 W659A,W777A,F794H None None XRAY 1.5 0.182 0.208 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8b9h TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR KDR VGFR2_HUMAN 3VO3A P35968 812 1168 1356.0 0KF:2001 Type2 Inactive DFGout 16.448 8.215 None -125.16, 179.81 -141.05, 99.79 -70.03, -34.74 215.55, 55.41 59.77, -120.61 in-in in 7.357 Saltbr-in 2.898 HRD-in -84.45, -53.71 76.95, -3.4 in-out-in SNCioi out-in ActLoopNT-out 16.477 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.91, 109.54 APE9-dihe-in -120.7, 147.5 APE8-dihe-in -78.09, 65.8 APE8-rot-na 32.33 APE67-dihe-in -67.73, -12.3 -53.4, -39.21 APE12-dist-na 17.03 APE11-dist-na 14.067 APE10-dist-na 11.393 APE9-dist-in 7.997 None None None XRAY 1.52 0.162 0.182 A 318 303 4 0 0 0 [[834, 1162]] 1.0 3vo3 TYR_KDR_HUMAN TYR 4.2e-100 340.3 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
TYR KDR VGFR2_HUMAN 1YWNA P35968 820 1171 1356.0 LIF:60301 Type1 Inactive None 999.0 999.0 None -128.91, 171.96 -143.62, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 7.21 Saltbr-in 2.725 HRD-in -77.88, -50.07 82.87, -17.6 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -141.39, 161.44 APE9-dihe-in -104.18, 100.32 APE8-dihe-out -56.09, -24.71 APE8-rot-na 336.02 APE67-dihe-in -70.59, -14.0 -51.58, -32.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.239 E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 1.71 0.206 0.23 A 316 281 21 0 0 6 [[834, 1162]] 1.0 1ywn TYR_KDR_HUMAN TYR 4.1e-100 340.3 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
TYR LCK LCK_HUMAN 2ZM1A P06239 231 501 509.0 KSF:513 Type1 Active DFGin 6.499 14.193 BLAminus -132.48, -160.42 31.13, 88.01 -99.25, 22.14 293.45, 97.67 -69.47, -32.89 in-in in 8.512 Saltbr-in 2.933 HRD-in -100.89, -51.07 73.44, -7.06 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.43, 148.33 APE9-dihe-in -138.82, 152.04 APE8-dihe-in -57.54, 117.05 APE8-rot-na 333.13 APE67-dihe-in -71.51, -24.6 -61.57, -39.74 APE12-dist-na 15.101 APE11-dist-na 10.35 APE10-dist-na 13.014 APE9-dist-in 6.822 None PTR394 PTR394 XRAY 2.1 0.172 0.232 A 285 271 0 0 0 0 [[245, 496]] 1.0 2zm1 TYR_LCK_HUMAN TYR 1.5e-94 322.1 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
TYR MERTK MERTK_HUMAN 9BHIA Q12866 578 864 999.0 A1APF:60901 Type1.5_Front Inactive DFGin 6.992 12.805 BLAminus -138.66, -158.87 44.96, 74.5 -90.39, 18.73 305.52, 137.7 -55.48, -30.3 out-out out 13.615 Saltbr-out 13.031 HRD-in -81.75, -51.8 68.35, 6.62 out-in-out SNCoio in-out ActLoopNT-in 2.82 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.15, 11.33 APE9-dihe-in -72.53, 150.77 APE8-dihe-in -64.75, 117.67 APE8-rot-na 25.92 APE67-dihe-in -73.91, -0.64 -53.67, -34.29 APE12-dist-na 7.154 APE11-dist-na 12.056 APE10-dist-na 11.657 APE9-dist-in 6.71 None None None XRAY 2.07 0.211 0.23 A 323 278 9 0 0 2 [[587, 856]] 1.0 9bhi TYR_MERTK_HUMAN TYR 1.6e-92 315.5 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AB1A Q12866 571 862 999.0 C6F:60901 Type1 Inactive DFGin 5.872 13.527 None -150.27, 178.21 48.78, 48.66 -107.87, 999.0 41.9, 85.18 999.0, 999.0 out-out out 12.844 Saltbr-out 9.566 HRD-in -84.92, -52.07 85.67, -41.55 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 62.29 APE8-rot-na 36.31 APE67-dihe-in -65.53, -14.5 -57.08, -42.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.93 0.237 0.298 A 298 267 25 0 0 20 [[587, 856]] 1.0 7ab1 TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MET MET_HUMAN 3ZCLA P08581 1052 1345 1390.0 5TF:1 Type1 Inactive DFGin 5.341 14.033 BLBplus -130.37, -159.34 48.43, 53.41 -147.61, 165.56 74.15, 92.01 59.61, -131.84 out-out out 14.636 Saltbr-out 12.785 HRD-in -76.45, -51.81 82.5, -13.86 out-out-in SNCooi out-in ActLoopNT-out 10.735 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.5, 109.91 APE9-dihe-in -127.18, 152.9 APE8-dihe-in -78.54, 68.73 APE8-rot-na 30.54 APE67-dihe-in -82.79, -0.65 -60.11, -28.04 APE12-dist-na 22.937 APE11-dist-na 18.131 APE10-dist-na 17.771 APE9-dist-in 7.357 None None None XRAY 1.4 0.194 0.211 A 306 291 3 0 0 0 [[1078, 1339]] 1.0 3zcl TYR_MET_HUMAN TYR 6.7e-92 313.6 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 4MXCA P08581 1052 1346 1390.0 DWF:1401 Type2 Inactive DFGout 14.41 10.337 BBAminus -151.35, -174.18 -156.99, 122.43 -67.95, -16.78 287.52, 70.23 58.23, -116.98 in-in in 8.929 Saltbr-in 3.515 HRD-in -73.25, -51.06 80.68, -17.87 in-out-in SNCioi out-in ActLoopNT-out 15.287 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -88.68, 108.68 APE9-dihe-in -118.71, 133.81 APE8-dihe-in -79.71, 72.93 APE8-rot-na 28.81 APE67-dihe-in -75.71, -5.79 -60.94, -31.89 APE12-dist-na 999.0 APE11-dist-na 13.628 APE10-dist-na 10.273 APE9-dist-in 7.344 None None None XRAY 1.632 0.18 0.207 A 319 290 5 0 0 5 [[1078, 1339]] 1.0 4mxc TYR_MET_HUMAN TYR 7.7e-92 313.7 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5H3QA P04629 484 796 796.0 7HF:1001 Type1 Inactive DFGout 12.708 6.583 BBAminus 172.54, 156.19 -157.42, 160.24 -99.39, 17.97 295.12, 97.4 79.34, 29.52 in-out in 9.447 Saltbr-out 5.851 HRD-in -81.9, -52.58 77.47, -12.71 out-out-in SNCooi out-in ActLoopNT-out 15.801 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -128.94, 112.39 APE9-dihe-in -107.73, 133.13 APE8-dihe-in -79.15, 63.42 APE8-rot-na 34.45 APE67-dihe-in -63.33, -18.08 -61.61, -34.65 APE12-dist-na 13.748 APE11-dist-na 15.2 APE10-dist-na 10.681 APE9-dist-in 7.568 None None None XRAY 2.1 0.19 0.215 A 324 303 10 0 0 0 [[510, 783]] 1.0 5h3q TYR_NTRK1_HUMAN TYR 2.4e-100 341.1 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5KMJA P04629 486 795 796.0 6UF:901 Type3 Inactive DFGout 12.074 7.602 None 156.98, 152.76 -155.56, 161.93 -106.33, 28.22 308.11, 127.92 67.17, 26.59 in-in in 9.714 Saltbr-in 2.772 HRD-in -79.87, -55.53 78.72, -12.42 in-out-in SNCioi out-in ActLoopNT-out 16.107 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.86, 120.05 APE9-dihe-in -107.69, 130.38 APE8-dihe-in -83.48, 63.94 APE8-rot-na 32.0 APE67-dihe-in -63.64, -21.11 -52.37, -37.83 APE12-dist-na 15.016 APE11-dist-na 15.494 APE10-dist-na 11.096 APE9-dist-in 7.6 None None None XRAY 2.04 0.196 0.226 A 329 300 6 0 0 0 [[510, 783]] 1.0 5kmj TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR PTK2 FAK1_HUMAN 4EBWA Q05397 411 686 1052.0 0PF:700 Type1 Inactive DFGinter 10.52 8.023 None -156.77, 167.19 -119.55, 38.35 -154.8, 160.1 57.14, 97.67 -105.09, 155.15 in-in in 7.232 Saltbr-in 3.021 HRD-out -85.85, 108.83 -92.42, -13.42 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 105.2 APE9-dihe-in -103.42, 143.85 APE8-dihe-in -74.96, 72.04 APE8-rot-na 29.05 APE67-dihe-in -70.29, -24.24 -52.29, -39.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 17.857 APE9-dist-out 9.391 None None None XRAY 2.65 0.186 0.273 A 304 259 17 0 0 15 [[422, 678]] 1.0 4ebw TYR_PTK2_HUMAN TYR 4.7e-93 317.2 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR SYK KSYK_HUMAN 5LMBA P43405 364 634 635.0 6ZF:701 Type1 Active DFGin 6.448 14.283 BLAminus -131.02, -173.87 62.28, 69.39 -93.16, 19.0 290.08, 82.25 -59.68, -28.46 in-in in 7.696 Saltbr-in 2.454 HRD-in -78.06, -53.9 76.38, 4.89 in-in-in SNCiii in-in ActLoopNT-in 2.963 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.66, 104.96 APE9-dihe-in -108.73, 152.4 APE8-dihe-in -79.7, 70.25 APE8-rot-na 31.84 APE67-dihe-in -69.34, -16.13 -51.43, -34.69 APE12-dist-na 13.073 APE11-dist-na 10.546 APE10-dist-na 11.448 APE9-dist-in 6.959 None PTR525 PTR525 XRAY 1.95 0.178 0.228 A 277 265 6 0 0 0 [[370, 628]] 1.0 5lmb TYR_SYK_HUMAN TYR 4.6e-90 307.4 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 5LMBB P43405 364 630 635.0 6ZF:701 Type1 None DFGin 6.542 14.207 BLAminus -133.05, -174.7 62.98, 72.21 -97.02, 21.38 290.54, 88.36 -62.52, -32.46 in-in in 7.737 Saltbr-in 2.556 HRD-in -77.26, -52.74 74.6, 8.57 in-in-none SNCiin in-none ActLoopNT-in 2.872 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.43 APE8-dihe-in -80.7, 73.18 APE8-rot-na 30.16 APE67-dihe-in -64.42, -18.25 -49.18, -37.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.948 None PTR525 PTR525 XRAY 1.95 0.178 0.228 B 277 262 5 0 0 5 [[370, 628]] 1.0 5lmb TYR_SYK_HUMAN TYR 4.6e-90 307.4 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4YJOA P43405 363 632 635.0 4DF:701 Type1 Active DFGin 7.151 15.404 BLAminus -136.57, 178.57 59.58, 80.7 -95.16, 22.65 286.36, 75.19 -55.96, -31.16 in-in in 8.32 Saltbr-in 3.044 HRD-in -80.48, -52.4 72.29, 6.84 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -56.5, 127.44 APE9-dihe-in -144.08, 83.31 APE8-dihe-in -75.74, 70.97 APE8-rot-na 33.07 APE67-dihe-in -63.43, -16.56 -52.99, -37.5 APE12-dist-na 999.0 APE11-dist-na 10.63 APE10-dist-na 7.9 APE9-dist-in 7.507 None None None XRAY 1.6 0.186 0.23 A 281 267 3 0 0 3 [[370, 628]] 1.0 4yjo TYR_SYK_HUMAN TYR 4.8e-90 307.3 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 5TT7A P43405 358 635 635.0 7KF:60901 Type1 Active DFGin 6.311 14.341 BLAminus -130.62, -177.29 62.11, 72.82 -94.96, 21.67 289.95, 80.8 -60.6, -26.94 in-in in 7.709 Saltbr-in 2.84 HRD-in -77.7, -52.28 69.96, 13.2 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.65, 88.09 APE9-dihe-in -107.14, 140.48 APE8-dihe-in -78.3, 78.38 APE8-rot-na 32.04 APE67-dihe-in -64.56, -15.37 -56.64, -35.35 APE12-dist-na 13.888 APE11-dist-na 10.557 APE10-dist-na 10.342 APE9-dist-in 6.849 None None None XRAY 1.77 0.208 0.234 A 289 270 8 0 0 0 [[370, 628]] 1.0 5tt7 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4FYOA P43405 363 635 635.0 0VF:60701 Type1 None DFGin 6.527 14.676 BLAminus -132.65, -177.95 62.23, 72.42 -93.99, 21.12 289.45, 90.18 -61.07, -25.58 in-in in 7.75 Saltbr-in 2.757 HRD-in -74.26, -50.97 72.76, 4.05 in-in-none SNCiin in-none ActLoopNT-in 2.952 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 140.05 APE9-dihe-in -108.11, 144.2 APE8-dihe-in -76.07, 73.27 APE8-rot-na 27.85 APE67-dihe-in -65.29, -14.44 -52.41, -38.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.947 APE9-dist-in 7.308 None None None XRAY 1.4 0.22 0.24 A 291 263 10 0 0 4 [[370, 628]] 1.0 4fyo TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4GFGA P43405 363 635 635.0 0XF:60701 Type1 Active DFGin 6.382 14.706 BLAminus -133.41, -165.6 61.44, 68.78 -94.44, 29.51 290.84, 74.86 -64.09, -30.1 in-in in 8.551 Saltbr-in 3.497 HRD-in -86.12, -47.8 68.36, 5.25 in-in-in SNCiii in-in ActLoopNT-in 2.866 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -53.12, 138.6 APE9-dihe-in -110.15, 137.21 APE8-dihe-in -65.63, 68.92 APE8-rot-na 25.72 APE67-dihe-in -68.08, -17.47 -52.98, -35.53 APE12-dist-na 9.582 APE11-dist-na 10.629 APE10-dist-na 11.706 APE9-dist-in 7.231 None None None XRAY 2.35 0.221 0.246 A 291 273 0 0 0 0 [[370, 628]] 1.0 4gfg TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK

Ligand: F

Total number of chains: 181
Active chains: 40
Total number of genes: 65
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 86 47.5% 4AW0A
DFGin ABAminus 22 12.2% 7PIEA
DFGin BLAplus 19 10.5% 9UHIA
DFGin None 16 8.8% 8B9EA
DFGin BLBplus 10 5.5% 3ZCLA
DFGout BBAminus 10 5.5% 4MXCA
DFGout None 9 5.0% 3VO3A
DFGin BLBminus 4 2.2% 5R9OA
DFGin BLBtrans 2 1.1% 2R3IA
None None 2 1.1% 5IEXA
DFGinter None 1 0.6% 4EBWA

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC PRKACA KAPCA_CRIGR 7PIEA P25321 1 351 351.0 7QF:60401 Type1 Inactive DFGin 6.437 14.708 ABAminus -120.2, -32.0 -97.5, 116.46 -117.79, 21.67 284.38, 87.37 -67.96, -24.99 in-in in 9.018 Saltbr-in 2.947 HRD-in -90.08, -55.75 70.92, 8.29 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.9, 155.75 APE9-dihe-na 129.48, -166.45 APE8-dihe-in -116.19, 135.64 APE8-rot-in 298.32 APE67-dihe-in -59.08, -26.0 -47.12, -51.73 APE12-dist-in 8.298 APE11-dist-in 11.483 APE10-dist-in 5.921 APE9-dist-in 3.894 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.427 0.137 0.158 A 353 350 0 0 0 0 [[44, 298]] 1.0 7pie Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 9RETA P25321 13 351 351.0 A1JEF:60404 Allosteric Active DFGin 6.503 14.919 BLAminus -121.64, 161.02 79.66, 89.44 -97.28, 25.84 271.42, 57.67 -59.32, -29.98 in-in in 9.058 Saltbr-in 2.688 HRD-in -91.57, -50.28 65.7, 14.34 in-in-in SNCiii in-in ActLoopNT-in 2.961 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.82, 155.57 APE9-dihe-na 119.38, 155.92 APE8-dihe-in -73.83, 138.5 APE8-rot-in 315.72 APE67-dihe-in -57.32, -25.4 -54.39, -42.36 APE12-dist-in 8.186 APE11-dist-in 11.402 APE10-dist-in 5.952 APE9-dist-in 4.241 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.75 0.193 0.227 A 353 339 0 0 0 0 [[44, 298]] 1.0 9ret Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
TYR SRC SRC_CHICK 5SYSA P00523 258 533 533.0 72F:600 Type2 Inactive DFGout 13.354 9.801 BBAminus -126.48, -173.83 -168.38, 115.62 -104.78, -47.96 311.28, 146.33 163.56, 999.0 in-in in 8.579 Saltbr-in 3.03 HRD-in -86.37, -44.08 72.1, 11.73 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -16.31 APE8-rot-na 5.39 APE67-dihe-in -61.6, -39.03 -88.61, -20.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V281C None None XRAY 2.8 0.288 0.334 A 286 258 18 0 0 18 [[267, 518]] 1.0 5sys Gallus gallus TYR_SRC_CHICK TYR 4.2e-93 317.3 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 5SYSB P00523 258 533 533.0 72F:600 Type2 Inactive DFGout 13.413 10.163 BBAminus -126.31, -175.1 -166.31, 115.77 -103.34, -47.57 306.63, 130.98 67.96, 999.0 in-in in 8.321 Saltbr-in 3.044 HRD-in -86.54, -44.23 72.2, 11.45 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -18.84 APE8-rot-na 6.43 APE67-dihe-in -61.0, -39.73 -89.58, -19.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V281C None None XRAY 2.8 0.288 0.334 B 286 258 18 0 0 18 [[267, 518]] 1.0 5sys Gallus gallus TYR_SRC_CHICK TYR 4.2e-93 317.3 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
AGC AKT1 AKT1_HUMAN 4EKLA P31749 144 478 480.0 0RF:501 Type1 Active DFGin 6.496 13.423 BLAminus -130.08, 156.46 77.16, 99.77 -112.66, 14.16 298.65, 90.33 -61.32, -30.96 in-in in 8.958 Saltbr-in 2.452 HRD-in -78.38, -44.96 68.93, -13.6 in-in-in SNCiii in-in ActLoopNT-in 2.757 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.83, 160.76 APE9-dihe-na 116.71, 166.32 APE8-dihe-in -83.66, 133.51 APE8-rot-in 293.53 APE67-dihe-in -68.09, -18.95 -43.13, -46.31 APE12-dist-in 8.36 APE11-dist-in 11.512 APE10-dist-in 6.011 APE9-dist-in 4.443 S473D TPO308 TPO308 XRAY 2.0 0.175 0.235 A 341 330 0 0 0 0 [[150, 408]] 1.0 4ekl Homo sapiens AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1 260 260 291 292 293 295 297 179 198 202 271 273 272 274 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC GRK5 GRK5_HUMAN 9BRPA P34947 25 542 590.0 A1ARF:601 Type1 Inactive DFGin 6.253 12.479 ABAminus -116.3, -61.02 -91.04, 101.81 -97.25, 10.66 289.92, 84.11 -59.57, -18.7 in-in in 8.91 Saltbr-in 3.037 HRD-in -85.07, -56.86 71.89, 13.22 in-in-in SNCiii in-in ActLoopNT-in 3.105 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.18, 177.63 APE9-dihe-na 122.23, -155.28 APE8-dihe-in -122.73, 136.27 APE8-rot-in 286.0 APE67-dihe-inflip 100.9, -21.88 -54.82, 128.22 APE12-dist-in 9.574 APE11-dist-in 11.932 APE10-dist-in 6.253 APE9-dist-in 4.143 D311N None None XRAY 2.8 0.245 0.283 A 598 502 0 0 0 0 [[186, 448]] 1.0 9brp Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BREA P34947 25 542 590.0 W3F:601 Type1 Active DFGin 6.176 12.564 BLAminus -128.67, 172.15 57.35, 77.75 -93.22, 24.8 286.17, 72.14 -63.15, -21.99 in-in in 8.801 Saltbr-in 2.458 HRD-in -88.2, -51.09 67.29, 13.94 in-in-in SNCiii in-in ActLoopNT-in 3.127 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.49, 165.19 APE9-dihe-na 125.58, -150.88 APE8-dihe-in -124.55, 138.39 APE8-rot-in 312.36 APE67-dihe-inflip 92.11, -16.19 -53.44, 132.83 APE12-dist-in 9.943 APE11-dist-in 12.131 APE10-dist-in 6.337 APE9-dist-in 4.122 D311N None None XRAY 2.8 0.215 0.26 A 598 503 0 0 0 0 [[186, 448]] 1.0 9bre Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 8UAQA P34947 25 542 590.0 W3F:601 Type1 Inactive DFGin 6.02 12.841 None -112.48, -65.82 -86.97, 96.33 -93.06, 17.75 286.66, 70.13 -64.2, -19.76 in-in in 9.334 Saltbr-in 3.369 HRD-in -90.24, -57.5 70.99, -0.54 in-in-in SNCiii in-in ActLoopNT-in 3.037 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.56, 170.13 APE9-dihe-na 119.68, -157.85 APE8-dihe-in -112.7, 143.6 APE8-rot-in 314.4 APE67-dihe-inflip 89.64, -4.73 -59.54, 131.81 APE12-dist-in 9.916 APE11-dist-in 12.102 APE10-dist-in 6.306 APE9-dist-in 4.174 D311N None None XRAY 2.8 0.232 0.277 A 598 501 0 0 0 0 [[186, 448]] 1.0 8uaq Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC PDPK1 PDPK1_HUMAN 4AW0A O15530 75 359 556.0 ATP:500,MJF:600 ATPlike,Allosteric Active DFGin 6.531 14.993 BLAminus -134.84, 177.25 78.73, 76.19 -106.3, 8.53 283.51, 97.11 -69.63, -19.36 in-in in 8.595 Saltbr-in 3.009 HRD-in -83.05, -53.03 79.45, -12.94 in-in-in SNCiii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.69, 159.04 APE9-dihe-na 139.48, -167.8 APE8-dihe-in -131.87, 132.42 APE8-rot-in 295.45 APE67-dihe-in -61.29, -25.28 -54.74, -42.17 APE12-dist-in 7.509 APE11-dist-in 10.601 APE10-dist-in 5.026 APE9-dist-in 3.58 Y288G,Q292A SEP241 SEP241,CME260 XRAY 1.43 0.171 0.188 A 311 285 0 0 0 0 [[82, 342]] 1.0 4aw0 Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PRKCH KPCL_HUMAN 8FP1A P24723 349 676 683.0 XXF:9000 Type1 Active DFGin 6.04 12.861 BLAminus -134.17, 160.39 76.6, 103.68 -113.44, 14.82 306.37, 103.97 -62.81, -37.48 in-in in 8.529 Saltbr-in 2.747 HRD-in -71.28, -48.4 60.66, 8.21 in-in-in SNCiii in-in ActLoopNT-in 3.042 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -168.52, 169.89 APE9-dihe-na 121.68, 166.05 APE8-dihe-in -83.39, 128.15 APE8-rot-in 297.95 APE67-dihe-in -61.25, -27.98 -43.8, -44.17 APE12-dist-in 8.666 APE11-dist-in 11.701 APE10-dist-in 6.365 APE9-dist-in 3.566 S675E TPO513,TPO656 TPO513,TPO656 XRAY 1.85 0.2 0.234 A 353 328 0 0 0 0 [[355, 614]] 1.0 8fp1 Homo sapiens AGC_PRKCH_HUMAN AGC 1.6e-97 331.6 1 260 260 496 497 498 500 502 384 403 407 476 478 477 479 536 524 519 518 517 516 515 514 513 434 Protein kinase C eta type
CAMK AURKA AURKA_HUMAN 8C1DA O14965 127 388 403.0 T2F:401,ADP:402,T5L:405 Allosteric,ATPlike,Allosteric Inactive DFGin 5.59 14.77 BLAminus -129.39, 179.64 57.3, 80.97 -92.88, 23.53 280.13, 79.47 -56.16, -33.44 in-in in 9.306 Saltbr-in 2.936 HRD-in -72.1, -50.49 67.69, -1.24 in-in-out SNCiio in-out ActLoopNT-in 2.796 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 144.85 APE8-dihe-in -64.26, 154.27 APE8-rot-out 88.6 APE67-dihe-in -39.49, -36.75 -82.32, -6.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.088 C290A None None XRAY 2.115 0.212 0.238 A 265 259 3 0 0 3 [[133, 383]] 1.0 8c1d Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2W1FA O14965 127 389 403.0 L0F:61390 Type1 Inactive DFGin 5.655 15.703 BLAminus -96.26, 172.45 62.06, 107.69 -118.91, 38.89 289.12, 66.42 -59.62, -48.4 out-out out 10.139 Saltbr-out 5.12 HRD-in -78.79, -54.88 78.03, -25.41 out-in-out SNCoio in-out ActLoopNT-in 2.676 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -157.03 APE8-dihe-in -58.47, 105.92 APE8-rot-out 190.33 APE67-dihe-in -42.4, -27.58 -64.36, -20.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.774 None None None XRAY 2.85 0.246 0.348 A 275 253 10 0 0 10 [[133, 383]] 1.0 2w1f Homo sapiens CAMK_AURKA_HUMAN CAMK 6.7e-80 274.0 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3O51A O14965 126 388 403.0 LJF:1 Type1.5_Front Inactive DFGout 12.921 9.215 None -125.94, 46.56 -78.14, 156.47 -164.09, 999.0 59.42, 112.33 999.0, 999.0 out-none out 12.863 Saltbr-none 999.0 HRD-out -126.02, 153.87 -92.88, -115.51 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -57.91, -10.7 999.0, -51.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.288 0.304 A 267 246 17 0 0 17 [[133, 383]] 1.0 3o51 Homo sapiens CAMK_AURKA_HUMAN CAMK 6e-80 274.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK CAMK2A KCC2A_HUMAN 2VZ6A Q9UQM7 9 299 478.0 FEF:60600 Type1 Active DFGin 7.124 13.93 BLAminus -130.3, 144.9 77.59, 104.3 -118.45, 37.91 281.19, 70.53 -60.86, -31.43 in-in in 9.032 Saltbr-in 2.623 HRD-in -71.43, -45.76 75.34, -9.9 in-in-in SNCiii in-in ActLoopNT-in 2.805 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.76, 148.02 APE9-dihe-na 132.07, -168.34 APE8-dihe-in -120.79, 126.49 APE8-rot-in 299.71 APE67-dihe-in -63.07, -18.83 -35.01, -58.7 APE12-dist-in 10.327 APE11-dist-in 11.819 APE10-dist-in 5.993 APE9-dist-in 3.832 None None None XRAY 2.3 0.165 0.203 A 313 289 2 0 0 0 [[13, 271]] 1.0 2vz6 Homo sapiens CAMK_CAMK2A_HUMAN CAMK 1.6e-96 328.7 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 2VZ6B Q9UQM7 9 300 478.0 FEF:60600 Type1 Active DFGin 6.865 14.032 BLAminus -131.92, 139.26 77.54, 110.88 -122.08, 32.95 286.68, 71.96 -61.55, -26.54 in-in in 9.31 Saltbr-in 2.931 HRD-in -73.12, -44.65 73.93, -20.22 in-in-in SNCiii in-in ActLoopNT-in 2.874 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.21, 149.78 APE9-dihe-na 143.11, -171.05 APE8-dihe-in -118.3, 128.44 APE8-rot-in 303.95 APE67-dihe-in -66.72, -18.78 -39.97, -52.82 APE12-dist-in 10.252 APE11-dist-in 11.756 APE10-dist-in 5.996 APE9-dist-in 3.963 None None None XRAY 2.3 0.165 0.203 B 313 292 0 0 0 0 [[13, 271]] 1.0 2vz6 Homo sapiens CAMK_CAMK2A_HUMAN CAMK 1.6e-96 328.7 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CHEK1 CHK1_HUMAN 8E80A O14757 8 271 476.0 UUF:301 Type1 Active DFGin 6.948 13.561 BLAminus -116.38, 163.51 69.37, 105.0 -111.89, 20.17 292.16, 81.73 -65.53, -30.68 in-in in 8.579 Saltbr-in 2.859 HRD-in -73.57, -45.75 72.69, 0.21 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.33, 170.54 APE9-dihe-na 117.83, -149.18 APE8-dihe-in -134.92, 121.74 APE8-rot-in 303.05 APE67-dihe-in -62.91, -20.27 -44.12, -51.23 APE12-dist-in 9.365 APE11-dist-in 11.644 APE10-dist-in 6.142 APE9-dist-in 3.497 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.49 0.209 0.242 A 297 258 6 0 0 0 [[9, 265]] 1.0 8e80 Homo sapiens CAMK_CHEK1_HUMAN CAMK 4.8e-69 238.4 2 256 255 147 148 149 151 153 38 55 59 127 129 128 130 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK2 CHK2_HUMAN 2YCFA O96017 210 510 543.0 YCF:600 Type1 Inactive DFGin 6.651 14.425 BLAminus -133.14, 179.08 68.92, 89.26 -105.02, 26.49 290.18, 77.38 -65.99, -23.19 in-out in 9.994 Saltbr-out 8.56 HRD-in -70.72, -52.98 75.15, -0.9 out-in-out SNCoio in-out ActLoopNT-in 2.905 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -72.28, -26.54 APE9-dihe-na -96.81, -179.54 APE8-dihe-in -85.38, 132.85 APE8-rot-in 297.44 APE67-dihe-in -44.53, -40.92 -82.1, 28.65 APE12-dist-out 25.231 APE11-dist-out 27.289 APE10-dist-out 29.363 APE9-dist-out 33.105 None None None XRAY 1.77 0.197 0.218 A 322 286 15 0 0 0 [[220, 486]] 1.0 2ycf Homo sapiens CAMK_CHEK2_HUMAN CAMK 2e-85 292.2 1 256 256 367 368 369 371 373 249 273 277 344 346 345 347 409 394 389 388 387 386 385 384 383 302 Serine/threonine-protein kinase Chk2
CAMK DAPK1 DAPK1_HUMAN 6AARA P53355 2 277 1430.0 9TF:300 Type1 Inactive DFGin 6.743 14.342 BLAminus -121.31, 178.32 64.29, 78.62 -87.38, 15.28 286.92, 75.84 -59.31, -26.74 in-in in 9.386 Saltbr-in 2.811 HRD-in -76.03, -46.41 70.92, -12.19 in-in-out SNCiio in-out ActLoopNT-in 2.921 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -137.91, 116.13 APE9-dihe-na -97.58, -145.9 APE8-dihe-in -81.4, 124.5 APE8-rot-in 302.0 APE67-dihe-in -55.21, -31.9 -47.73, -42.04 APE12-dist-in 11.019 APE11-dist-out 6.26 APE10-dist-out 9.242 APE9-dist-in 4.805 None None None XRAY 1.95 0.182 0.22 A 293 269 7 0 0 0 [[13, 275]] 1.0 6aar Homo sapiens CAMK_DAPK1_HUMAN CAMK 6.1e-95 323.3 1 256 256 160 161 162 164 166 42 64 68 136 138 137 139 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK MAPKAPK2 MAPK2_HUMAN 3M42A P49137 47 364 400.0 HGF:365 Type1 None DFGin 4.265 13.765 BLAminus -127.28, 170.7 71.87, 101.44 -103.87, 20.75 277.01, 69.5 -61.92, -8.22 in-in in 9.26 Saltbr-in 3.091 HRD-in -73.72, -58.45 76.25, 11.76 in-in-none SNCiin in-none ActLoopNT-in 2.912 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 P237G None None XRAY 2.68 0.186 0.232 A 299 290 7 0 0 0 [[63, 325]] 1.0 3m42 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 1.9e-36 228.6 3 154 236 206 207 208 210 212 93 104 108 183 185 184 186 245 0 0 0 0 0 0 0 0 139 MAP kinase-activated protein kinase 2
CAMK MELK MELK_HUMAN 5IH9A Q14680 3 327 651.0 6BF:60401 Type1 None DFGin 6.939 15.146 BLAminus -123.48, 176.08 58.26, 79.91 -95.72, 21.84 280.98, 78.3 -67.92, -25.97 in-in in 8.72 Saltbr-in 2.587 HRD-in -71.83, -48.59 72.02, -0.04 in-in-none SNCiin in-none ActLoopNT-in 2.992 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -4.81 APE8-rot-in 291.01 APE67-dihe-in -55.95, -27.86 -55.75, -43.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.79 0.174 0.2 A 335 307 18 0 0 14 [[11, 263]] 1.0 5ih9 Homo sapiens CAMK_MELK_HUMAN CAMK 9.7e-89 303.1 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK PIM1 PIM1_HUMAN 5KGIA P11309 33 305 313.0 6SF:414 Type1 Active DFGin 6.196 14.678 BLAminus -128.85, 173.72 58.37, 80.83 -91.15, 15.65 283.15, 78.86 -67.29, -15.19 in-in in 8.898 Saltbr-in 2.699 HRD-na-A -66.85, -48.52 69.49, 3.32 in-in-in SNCiii in-in ActLoopNT-in 2.854 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.48, 30.3 APE9-dihe-na -88.67, -155.26 APE8-dihe-in -89.24, 121.14 APE8-rot-in 310.96 APE67-dihe-in -66.24, -12.88 -55.29, -44.34 APE12-dist-in 9.723 APE11-dist-in 8.735 APE10-dist-in 5.642 APE9-dist-in 3.74 None None None XRAY 2.13 0.173 0.186 A 276 273 0 0 0 0 [[38, 290]] 1.0 5kgi Homo sapiens CAMK_PIM1_HUMAN CAMK 2.5e-65 226.2 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 6L13A P11309 33 305 313.0 E2F:401 Type1 Active DFGin 6.19 14.786 BLAminus -130.24, 168.2 68.46, 80.68 -89.17, 16.05 288.1, 80.31 -69.01, -19.61 in-in in 9.105 Saltbr-in 2.936 HRD-na-A -68.46, -51.8 71.9, 8.52 in-in-in SNCiii in-in ActLoopNT-in 2.778 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.76, 29.56 APE9-dihe-na -92.34, -153.25 APE8-dihe-in -98.43, 124.2 APE8-rot-in 303.55 APE67-dihe-in -68.48, -12.49 -58.68, -45.06 APE12-dist-in 9.5 APE11-dist-in 8.511 APE10-dist-in 5.099 APE9-dist-in 3.659 None SEP261 SEP261 XRAY 2.24 0.18 0.214 A 289 273 0 0 0 0 [[38, 290]] 1.0 6l13 Homo sapiens CAMK_PIM1_HUMAN CAMK 3e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 2O65A P11309 33 306 313.0 MYF:501 Type1 Active DFGin 5.773 14.223 BLAminus -134.9, 170.04 60.08, 89.22 -101.35, 10.62 287.34, 92.73 -63.96, -9.9 in-in in 8.704 Saltbr-in 2.471 HRD-na-A -65.14, -47.59 70.03, -4.07 in-in-in SNCiii in-in ActLoopNT-in 2.98 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.66, 34.64 APE9-dihe-na -104.35, -148.26 APE8-dihe-in -83.11, 121.1 APE8-rot-in 316.59 APE67-dihe-in -62.15, -16.44 -57.04, -47.52 APE12-dist-in 9.988 APE11-dist-in 8.628 APE10-dist-in 5.289 APE9-dist-in 4.136 None None None XRAY 2.85 0.21 0.262 A 293 274 0 0 0 0 [[38, 290]] 1.0 2o65 Homo sapiens CAMK_PIM1_HUMAN CAMK 3.2e-65 226.0 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 8R0WA P11309 33 305 313.0 XGF:405 Type1 Active DFGin 5.997 14.384 BLAminus -131.73, 166.77 65.97, 82.46 -89.79, 16.41 289.35, 79.56 -63.02, -16.4 in-in in 8.812 Saltbr-in 2.643 HRD-na-A -73.15, -45.35 65.43, 10.88 in-in-in SNCiii in-in ActLoopNT-in 2.855 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.23, 17.26 APE9-dihe-na -81.93, -156.28 APE8-dihe-in -91.39, 121.88 APE8-rot-in 296.84 APE67-dihe-in -71.92, -8.94 -64.52, -38.27 APE12-dist-in 9.559 APE11-dist-in 8.479 APE10-dist-in 5.116 APE9-dist-in 3.713 R250G SEP261 SEP261 XRAY 1.95 0.167 0.201 A 313 273 0 0 0 0 [[38, 290]] 1.0 8r0w Homo sapiens CAMK_PIM1_HUMAN CAMK 1.5e-64 223.7 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 8AFRA P11309 33 305 313.0 M0F:401 Type1 Active DFGin 6.024 14.406 BLAminus -126.46, 177.16 55.61, 83.44 -89.48, 19.88 284.93, 74.96 -67.33, -13.52 in-in in 8.831 Saltbr-in 2.648 HRD-na-A -72.52, -48.51 66.56, 10.77 in-in-in SNCiii in-in ActLoopNT-in 2.815 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.4, 19.87 APE9-dihe-na -78.39, -149.93 APE8-dihe-in -97.85, 123.61 APE8-rot-in 301.25 APE67-dihe-in -68.16, -10.25 -64.9, -40.75 APE12-dist-in 9.727 APE11-dist-in 8.467 APE10-dist-in 5.304 APE9-dist-in 3.645 R250G SEP261 SEP261 XRAY 2.15 0.166 0.191 A 309 264 7 0 0 0 [[38, 290]] 1.0 8afr Homo sapiens CAMK_PIM1_HUMAN CAMK 3.1e-62 216.2 1 256 256 185 186 187 189 191 67 89 93 164 166 165 167 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CMGC CDK12 CDK12_HUMAN 8BU5B Q9NYV4 713 1044 1490.0 RMF:1101 Type1 Inactive DFGin 6.801 14.701 ABAminus -126.95, -66.04 -93.95, 105.24 -102.41, 30.18 293.69, 100.66 -84.84, -22.58 in-out in 8.305 Saltbr-out 3.933 HRD-out -78.59, 106.12 -94.17, 5.74 out-in-out SNCoio in-out ActLoopNT-in 2.828 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -136.91, -22.25 APE9-dihe-na -109.89, 157.52 APE8-dihe-in -56.01, 131.78 APE8-rot-in 308.02 APE67-dihe-in -60.99, -26.61 -52.03, -40.26 APE12-dist-out 14.28 APE11-dist-in 11.941 APE10-dist-in 7.36 APE9-dist-in 3.767 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 B 344 332 0 0 0 0 [[727, 1020]] 1.0 8bu5 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU5H Q9NYV4 713 1043 1490.0 RMF:1101 Type1 Inactive DFGin 7.015 14.978 ABAminus -128.46, -54.53 -90.71, 103.12 -97.22, 31.8 290.43, 81.59 -85.33, -25.69 in-in in 8.479 Saltbr-in 3.527 HRD-in -73.55, -49.58 63.85, -4.76 in-in-in SNCiii in-in ActLoopNT-in 2.629 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.5, -28.02 APE9-dihe-na -97.36, 153.71 APE8-dihe-in -57.72, 135.61 APE8-rot-in 311.07 APE67-dihe-in -63.38, -27.52 -50.57, -39.59 APE12-dist-in 13.941 APE11-dist-in 12.128 APE10-dist-in 7.258 APE9-dist-in 3.497 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 H 344 331 0 0 0 0 [[727, 1020]] 1.0 8bu5 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUNB Q9NYV4 715 1041 1490.0 RNF:61101 Type1 Inactive DFGin 7.009 15.297 ABAminus -131.36, -49.43 -89.83, 91.44 -92.44, 32.63 287.3, 77.5 -75.27, -18.22 in-in in 7.748 Saltbr-in 3.279 HRD-in -75.67, -53.71 75.4, -0.11 in-in-in SNCiii in-in ActLoopNT-in 2.923 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -107.12, -39.12 APE9-dihe-na -104.98, 151.97 APE8-dihe-in -58.93, 142.91 APE8-rot-in 279.94 APE67-dihe-in -65.42, -33.6 -55.06, -35.14 APE12-dist-in 13.388 APE11-dist-in 11.695 APE10-dist-in 7.099 APE9-dist-in 3.657 K965R TPO893 TPO893 XRAY 3.08 0.187 0.211 B 344 327 0 0 0 0 [[727, 1020]] 1.0 8bun Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUNH Q9NYV4 715 1043 1490.0 RNF:61101 Type1 Inactive DFGin 7.045 15.286 ABAminus -125.24, -50.09 -100.69, 94.75 -92.24, 30.97 286.18, 71.82 -75.42, -18.26 in-in in 7.834 Saltbr-in 3.373 HRD-in -77.6, -54.36 73.0, -1.25 in-in-in SNCiii in-in ActLoopNT-in 2.74 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.56, -41.65 APE9-dihe-na -95.79, 153.05 APE8-dihe-in -58.87, 144.43 APE8-rot-in 305.25 APE67-dihe-in -65.98, -31.29 -55.83, -37.71 APE12-dist-in 13.775 APE11-dist-in 11.972 APE10-dist-in 6.957 APE9-dist-in 3.478 K965R TPO893 TPO893 XRAY 3.08 0.187 0.211 H 344 329 0 0 0 0 [[727, 1020]] 1.0 8bun Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 9FMRE Q9NYV4 714 1042 1490.0 RMF:61101 Type1 Inactive DFGin 6.793 14.64 ABAminus -113.83, -79.52 -84.15, 118.47 -115.27, 16.16 293.54, 100.02 -64.02, -34.33 in-out in 9.633 Saltbr-out 3.612 HRD-out -79.17, 82.22 -59.96, 8.89 out-in-out SNCoio in-out ActLoopNT-in 3.026 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -148.14, -27.51 APE9-dihe-na -104.44, 148.12 APE8-dihe-in -51.45, 137.55 APE8-rot-in 306.02 APE67-dihe-in -70.5, -21.3 -54.61, -36.19 APE12-dist-out 14.298 APE11-dist-in 12.211 APE10-dist-in 7.469 APE9-dist-in 3.767 None TPO893 TPO893 XRAY 3.9 0.209 0.25 E 351 329 0 0 0 0 [[727, 1020]] 1.0 9fmr Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 9FMRH Q9NYV4 714 1044 1490.0 RMF:61101 Type1 Inactive DFGin 6.801 14.603 ABAminus -113.95, -78.4 -84.85, 124.02 -118.87, 17.95 291.29, 89.7 -63.88, -35.4 in-in in 8.592 Saltbr-in 3.552 HRD-in -72.47, -40.65 59.82, 5.57 in-in-in SNCiii in-in ActLoopNT-in 2.944 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.74, -27.71 APE9-dihe-na -103.25, 148.34 APE8-dihe-in -51.07, 136.63 APE8-rot-in 306.14 APE67-dihe-in -69.99, -21.15 -54.39, -34.8 APE12-dist-in 13.823 APE11-dist-in 12.098 APE10-dist-in 7.255 APE9-dist-in 3.608 None TPO893 TPO893 XRAY 3.9 0.209 0.25 H 351 331 0 0 0 0 [[727, 1020]] 1.0 9fmr Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUNE Q9NYV4 715 1039 1490.0 RNF:61101 Type1 Inactive DFGin 7.217 15.313 BLAminus -143.55, -179.06 50.55, 77.42 -92.12, 34.85 285.27, 76.47 -72.26, -18.51 in-in in 7.824 Saltbr-in 3.046 HRD-in -77.13, -53.65 75.0, -0.22 in-in-out SNCiio in-out ActLoopNT-in 2.924 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -105.31, -34.23 APE9-dihe-na -92.08, 151.91 APE8-dihe-in -57.84, 145.99 APE8-rot-out 175.35 APE67-dihe-in -65.98, -29.37 -55.72, -38.5 APE12-dist-in 13.18 APE11-dist-in 12.611 APE10-dist-in 7.008 APE9-dist-in 3.432 K965R TPO893 TPO893 XRAY 3.08 0.187 0.211 E 344 325 0 0 0 0 [[727, 1020]] 1.0 8bun Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8P81A Q9NYV4 716 1035 1490.0 RMF:1101 Type1 Active DFGin 7.095 14.446 BLAminus -134.83, -178.64 59.2, 72.19 -89.53, 34.88 291.56, 80.44 -67.97, -22.73 in-in in 8.359 Saltbr-in 3.057 HRD-in -81.5, -42.97 59.01, 18.94 in-in-in SNCiii in-in ActLoopNT-in 2.963 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.63, 165.61 APE9-dihe-na 67.08, 139.25 APE8-dihe-in -61.99, 152.33 APE8-rot-in 316.49 APE67-dihe-in -68.12, -20.85 -57.98, -41.98 APE12-dist-in 12.679 APE11-dist-in 10.561 APE10-dist-in 6.52 APE9-dist-in 3.212 None TPO893 TPO893 XRAY 2.68 0.212 0.255 A 351 320 0 0 0 0 [[727, 1020]] 1.0 8p81 Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU5E Q9NYV4 713 1043 1490.0 RMF:1101 Type1 Inactive DFGin 6.942 15.122 None -123.64, -63.66 -81.97, -51.09 56.28, 22.54 292.49, 98.9 -91.33, -28.22 in-out in 8.371 Saltbr-out 3.622 HRD-in -72.77, -54.57 74.45, -4.91 out-in-out SNCoio in-out ActLoopNT-in 2.759 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -134.16, -27.33 APE9-dihe-na -98.05, 157.33 APE8-dihe-in -51.55, 136.25 APE8-rot-in 308.17 APE67-dihe-in -63.16, -26.85 -49.17, -41.17 APE12-dist-out 14.125 APE11-dist-in 12.168 APE10-dist-in 7.286 APE9-dist-in 3.726 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 E 344 331 0 0 0 0 [[727, 1020]] 1.0 8bu5 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 9FMRB Q9NYV4 714 1047 1490.0 RMF:61101 Type1 Inactive DFGin 7.124 15.031 None -111.49, -74.26 -77.99, -72.15 68.85, 12.84 296.16, 89.8 -66.22, -36.51 in-out in 8.332 Saltbr-out 4.45 HRD-in -70.8, -35.56 62.81, 1.22 out-in-in SNCoii in-in ActLoopNT-in 3.072 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.03, -25.75 APE9-dihe-na -103.56, 146.88 APE8-dihe-in -51.72, 138.27 APE8-rot-in 305.58 APE67-dihe-in -69.51, -21.36 -53.61, -35.19 APE12-dist-in 13.987 APE11-dist-in 12.27 APE10-dist-in 7.331 APE9-dist-in 3.865 None TPO893 TPO893 XRAY 3.9 0.209 0.25 B 351 334 0 0 0 0 [[727, 1020]] 1.0 9fmr Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1 301 301 876 877 878 880 882 756 774 778 856 858 857 859 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK16 CDK16_HUMAN 3MTLA Q00536 163 473 496.0 FEF:60668 Type1 Inactive DFGout 17.399 7.472 None -75.13, 154.32 -88.9, 77.74 -154.62, 116.54 227.56, 88.74 78.03, 21.89 in-in in 8.385 Saltbr-in 2.641 HRD-out -101.69, 108.56 -74.19, -25.04 in-out-out SNCioo out-out ActLoopNT-out 5.164 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 102.89 APE8-rot-out 156.53 APE67-dihe-in -61.54, -35.29 -78.56, -14.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S319D None None XRAY 2.4 0.198 0.263 A 324 293 18 0 0 12 [[165, 446]] 1.0 3mtl Homo sapiens CMGC_CDK16_HUMAN CMGC 1.3e-83 286.9 1 301 301 303 304 305 307 309 194 211 215 283 285 284 286 344 331 326 325 324 323 322 321 320 241 Cyclin-dependent kinase 16
CMGC CDK2 CDK2_HUMAN 9ESWA P24941 1 294 298.0 IJF:60301,IJF:60302,IJF:60303,IJF:60304 Allosteric,Type1,Allosteric,Allosteric Active DFGin 6.515 15.297 BLAminus -143.94, 174.07 58.52, 82.55 -94.4, 25.35 278.47, 68.95 -74.76, -22.16 in-in in 8.637 Saltbr-in 3.197 HRD-in -81.26, -58.57 77.56, 16.21 in-in-in SNCiii in-in ActLoopNT-in 2.996 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -61.44, 160.94 APE9-dihe-na 81.67, 126.4 APE8-dihe-in -51.25, 136.17 APE8-rot-in 300.7 APE67-dihe-in -59.48, -16.12 -52.59, -48.63 APE12-dist-in 12.997 APE11-dist-in 11.897 APE10-dist-in 7.023 APE9-dist-in 3.204 None TPO160 TPO160 XRAY 2.38 0.233 0.239 A 302 294 0 0 0 0 [[4, 286]] 1.0 9esw Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9ESWC P24941 1 296 298.0 IJF:60301,IJF:60302,IJF:60303,IJF:60304 Allosteric,Type1,Allosteric,Allosteric Active DFGin 6.576 15.209 BLAminus -137.9, -176.23 48.55, 71.41 -85.05, 25.18 283.44, 66.65 -62.35, -32.95 in-in in 8.417 Saltbr-in 2.763 HRD-in -83.58, -58.72 75.84, 9.9 in-in-in SNCiii in-in ActLoopNT-in 2.887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.32, 151.2 APE9-dihe-na 72.23, 131.64 APE8-dihe-in -58.77, 140.82 APE8-rot-in 312.4 APE67-dihe-in -51.92, -26.23 -42.04, -57.02 APE12-dist-in 12.776 APE11-dist-in 10.195 APE10-dist-in 6.943 APE9-dist-in 3.236 None TPO160 TPO160 XRAY 2.38 0.233 0.239 C 302 269 27 0 0 0 [[4, 286]] 1.0 9esw Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9OB4A P24941 1 298 298.0 A1CAF:301 Type1 Active DFGin 7.07 15.433 BLAminus -140.78, 171.16 58.81, 81.21 -94.48, 18.25 279.35, 70.51 -60.63, -24.89 in-in in 8.702 Saltbr-in 2.578 HRD-in -77.49, -52.8 70.85, 9.99 in-in-in SNCiii in-in ActLoopNT-in 2.858 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -103.4, 171.78 APE9-dihe-na 71.79, 138.58 APE8-dihe-in -59.97, 144.28 APE8-rot-in 298.9 APE67-dihe-in -65.05, -23.77 -53.99, -47.04 APE12-dist-in 13.149 APE11-dist-in 12.232 APE10-dist-in 7.357 APE9-dist-in 3.261 None TPO160 TPO160 XRAY 1.95 0.211 0.251 A 301 298 0 0 0 0 [[4, 286]] 1.0 9ob4 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4BCQA P24941 1 295 298.0 TJF:61296 Type1 Active DFGin 6.591 15.979 BLAminus -145.97, 170.46 62.82, 84.99 -99.38, 29.59 282.23, 71.6 -71.19, -18.61 in-in in 9.404 Saltbr-in 3.453 HRD-in -85.05, -58.94 78.36, 12.61 in-in-in SNCiii in-in ActLoopNT-in 3.147 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.8, 176.97 APE9-dihe-na 69.33, 133.29 APE8-dihe-in -55.38, 139.69 APE8-rot-in 304.09 APE67-dihe-in -55.84, -22.0 -49.63, -50.65 APE12-dist-in 13.625 APE11-dist-in 12.543 APE10-dist-in 7.498 APE9-dist-in 3.511 None TPO160 TPO160 XRAY 2.4 0.217 0.252 A 301 290 5 0 0 0 [[4, 286]] 1.0 4bcq Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4BCQC P24941 1 294 298.0 TJF:61295 Type1 Active DFGin 6.54 16.003 BLAminus -147.36, 170.23 59.21, 86.27 -98.9, 28.16 278.44, 72.82 -71.37, -12.42 in-in in 9.598 Saltbr-in 3.261 HRD-in -88.13, -59.99 74.18, 19.51 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.48, 157.26 APE9-dihe-na 69.58, 129.95 APE8-dihe-in -57.66, 135.49 APE8-rot-in 301.27 APE67-dihe-in -62.84, -20.05 -48.44, -46.81 APE12-dist-in 13.54 APE11-dist-in 10.682 APE10-dist-in 7.689 APE9-dist-in 3.66 None TPO160 TPO160 XRAY 2.4 0.217 0.252 C 301 292 2 0 0 0 [[4, 286]] 1.0 4bcq Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 7S9XA P24941 3 298 298.0 8KF:301 Type3 Inactive DFGin 9.152 14.904 BLBminus -140.51, 174.83 55.24, 52.61 -60.52, 155.06 283.44, 65.83 -96.54, 51.03 out-out out 17.021 Saltbr-out 17.405 HRD-in -80.98, -57.39 84.63, -18.55 out-out-out SNCooo out-out ActLoopNT-out 9.299 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 131.76 APE9-dihe-na -82.0, 133.39 APE8-dihe-in -82.83, 123.04 APE8-rot-in 299.71 APE67-dihe-in -59.76, -23.84 -102.49, -0.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.12 APE9-dist-out 11.022 None None None XRAY 1.69 0.231 0.262 A 298 269 27 0 0 12 [[4, 286]] 1.0 7s9x Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2W1HA P24941 1 298 298.0 L0F:1299 Type1 Inactive DFGin 10.307 17.775 BLBtrans -130.06, 151.5 79.56, 18.75 -69.93, 141.61 226.73, 121.67 69.65, -12.05 out-out out 14.489 Saltbr-out 16.038 HRD-in -88.39, -56.31 79.17, -16.22 out-out-out SNCooo out-out ActLoopNT-out 5.457 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 121.46 APE8-dihe-in -76.22, 142.93 APE8-rot-out 186.46 APE67-dihe-in -49.35, -36.85 -110.85, -4.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.805 None None None XRAY 2.15 0.263 0.308 A 298 283 15 0 0 11 [[4, 286]] 1.0 2w1h Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2R3IA P24941 1 298 298.0 SCF:60501 Type1 Inactive DFGin 10.929 18.24 BLBtrans -100.61, 149.54 71.45, 21.63 -58.2, 134.86 231.09, 103.4 83.18, -10.48 out-out out 15.057 Saltbr-out 16.345 HRD-in -91.01, -59.76 82.13, -15.3 out-out-out SNCooo out-out ActLoopNT-out 5.707 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.45, 127.61 APE9-dihe-na -74.97, 122.45 APE8-dihe-in -60.32, 144.67 APE8-rot-out 191.76 APE67-dihe-in -59.78, -26.25 -99.25, -5.87 APE12-dist-out 20.169 APE11-dist-out 17.538 APE10-dist-out 18.889 APE9-dist-out 9.991 None None CSD177 XRAY 1.28 0.178 0.202 A 299 291 7 0 0 0 [[4, 286]] 1.0 2r3i Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 5IEXA P24941 1 298 298.0 6AF:1001 Type1 Inactive None 11.106 18.344 None -105.6, 149.53 71.37, 22.65 -61.85, 135.15 236.62, 103.3 74.49, -10.58 out-out out 15.176 Saltbr-out 15.226 HRD-in -80.72, -65.3 84.99, -26.41 out-out-out SNCooo out-out ActLoopNT-out 5.802 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 111.81 APE8-dihe-in -112.57, 117.73 APE8-rot-in 277.98 APE67-dihe-in -67.92, -29.52 -99.02, -2.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.275 None None None XRAY 2.03 0.206 0.254 A 298 285 13 0 0 8 [[4, 286]] 1.0 5iex Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK6 CDK6_HUMAN 9PE7A Q00534 10 301 326.0 A1CIF:900 Type1 Inactive DFGin 6.872 13.127 BLBplus -137.4, 169.29 57.4, 61.63 -142.77, 164.35 61.09, 86.59 91.92, -16.71 out-out out 12.416 Saltbr-out 9.93 HRD-in -63.73, -52.58 73.19, -16.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 162.46 APE9-dihe-na -100.9, 174.34 APE8-dihe-in -134.69, 96.5 APE8-rot-in 306.93 APE67-dihe-in -54.43, -27.6 -93.0, -5.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 22.373 APE9-dist-out 12.123 E21V,K26T,T106R,Q149E None None XRAY 2.05 0.216 0.267 A 307 262 30 0 0 12 [[13, 300]] 1.0 9pe7 Homo sapiens CMGC_CDK6_HUMAN CMGC 3.7e-84 289.5 1 301 301 162 163 164 166 168 43 61 65 142 144 143 145 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
CMGC CDK7 CDK7_HUMAN 8P71J P50613 10 310 346.0 X4F:60401 Type1 Active DFGin 6.832 15.304 BLAminus -139.46, 179.9 57.59, 64.02 -82.45, 17.71 282.17, 74.47 -64.72, -19.22 in-in in 8.103 Saltbr-in 2.694 HRD-in -67.33, -49.46 65.63, 5.51 in-in-in SNCiii in-in ActLoopNT-in 2.639 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.68, 168.49 APE9-dihe-na 67.33, 140.05 APE8-dihe-in -60.3, 143.93 APE8-rot-in 294.53 APE67-dihe-in -61.0, -25.19 -55.87, -41.76 APE12-dist-in 13.411 APE11-dist-in 11.192 APE10-dist-in 6.803 APE9-dist-in 3.276 None None None EM 2.0 999.0 999.0 J 349 286 15 0 0 0 [[12, 295]] 1.0 8p71 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK8 CDK8_HUMAN 9H8SA P49336 1 362 464.0 A1ITF:60509 Type1 Inactive DFGin 7.344 13.924 BLAminus -119.28, 163.44 74.84, 82.25 -92.61, 11.91 298.93, 132.0 -87.41, 10.8 in-in in 8.612 Saltbr-in 2.624 HRD-in -75.25, -51.5 79.06, -6.52 in-out-out SNCioo out-out ActLoopNT-out 8.659 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 160.05 APE8-rot-out 75.96 APE67-dihe-in -54.19, -23.95 -111.96, 19.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.157 0.197 0.248 A 414 335 27 0 0 17 [[22, 335]] 1.0 9h8s Homo sapiens CMGC_CDK8_HUMAN CMGC 6.3e-82 281.3 5 301 297 172 173 174 176 178 52 66 70 148 150 149 151 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CMGC CSNK2A1 CSK21_HUMAN 8AEMA P68400 3 329 391.0 LVF:407,ATP:408 Allosteric,ATPlike Active DFGin 7.399 16.187 BLAminus -114.2, -178.47 56.21, 75.05 -90.39, 15.9 296.69, 81.8 -66.43, -20.83 in-in in 9.132 Saltbr-in 2.816 HRD-in -72.91, -51.16 68.69, 11.11 in-in-in SNCiii in-in ActLoopNT-in 2.905 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.83, 169.06 APE9-dihe-na 58.87, 157.76 APE8-dihe-in -77.1, 150.54 APE8-rot-in 294.73 APE67-dihe-in -68.78, -13.55 -40.19, -53.95 APE12-dist-in 12.744 APE11-dist-in 10.417 APE10-dist-in 6.256 APE9-dist-in 3.215 R21S,K74A,K75A,K76A None None XRAY 1.6 0.19 0.212 A 328 327 0 0 0 0 [[39, 324]] 1.0 8aem Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 9EPWB P68400 3 333 391.0 A1H6F:406 Type1 Active DFGin 7.386 16.279 BLAminus -118.5, 178.76 54.91, 76.82 -86.63, 13.68 291.49, 81.55 -67.5, -20.83 out-in out 10.046 Saltbr-in 3.292 HRD-in -71.7, -52.07 70.7, 14.03 in-in-in SNCiii in-in ActLoopNT-in 2.882 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.62, 167.98 APE9-dihe-na 70.49, 159.89 APE8-dihe-in -76.41, 141.74 APE8-rot-in 289.66 APE67-dihe-in -68.82, -20.3 -42.56, -42.98 APE12-dist-in 12.795 APE11-dist-in 10.921 APE10-dist-in 6.279 APE9-dist-in 3.382 None None None XRAY 2.3 0.261 0.308 B 338 331 0 0 0 0 [[39, 324]] 1.0 9epw Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.4e-69 240.6 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 2ZJWA P68400 1 332 391.0 REF:336 Type1 Inactive DFGin 7.316 16.527 BLAminus -109.16, -168.7 44.38, 76.01 -90.89, 24.26 297.46, 77.89 -76.15, -7.13 in-in in 9.417 Saltbr-in 2.731 HRD-in -72.0, -50.11 70.44, 13.49 in-in-out SNCiio in-out ActLoopNT-in 2.907 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -14.58, 161.89 APE9-dihe-na 62.59, 163.98 APE8-dihe-in -84.5, 146.1 APE8-rot-out 153.88 APE67-dihe-in -63.0, -17.21 -40.84, -52.94 APE12-dist-in 12.607 APE11-dist-in 8.948 APE10-dist-in 5.933 APE9-dist-in 2.992 None None None XRAY 2.4 0.222 0.274 A 340 332 0 0 0 0 [[39, 324]] 1.0 2zjw Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.4e-69 240.5 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7I8AA P68400 3 329 391.0 A1B0F:401 Type1 Active DFGin 7.457 16.071 BLAminus -110.77, 179.22 49.98, 83.2 -97.8, 27.66 295.37, 80.49 -74.55, -21.62 in-in in 8.964 Saltbr-in 2.748 HRD-in -69.35, -49.91 66.48, 13.83 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.27, 172.69 APE9-dihe-na 60.01, 160.49 APE8-dihe-in -88.34, 150.2 APE8-rot-in 298.89 APE67-dihe-in -68.6, -15.9 -36.65, -52.88 APE12-dist-in 12.62 APE11-dist-in 10.174 APE10-dist-in 6.101 APE9-dist-in 3.048 R21S,K74A,K75A,K76A None None XRAY 1.84 0.196 0.234 A 328 323 4 0 0 0 [[39, 324]] 1.0 7i8a Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC DYRK1A DYR1A_HUMAN 6A1FA Q13627 134 483 763.0 9OF:807 Type1 Active DFGin 7.205 15.092 BLAminus -125.52, 173.04 69.56, 79.06 -100.37, 18.23 289.23, 81.85 -66.74, -28.25 in-in in 8.712 Saltbr-in 2.843 HRD-in -63.72, -44.37 75.39, -2.34 in-in-in SNCiii in-in ActLoopNT-in 2.826 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.51, 164.33 APE9-dihe-na 78.19, 142.16 APE8-dihe-in -71.23, 146.24 APE8-rot-in 287.31 APE67-dihe-in -64.89, -24.24 -54.81, -45.1 APE12-dist-in 13.001 APE11-dist-in 10.937 APE10-dist-in 7.397 APE9-dist-in 3.189 None PTR321 PTR321 XRAY 1.5 0.178 0.195 A 360 346 4 0 0 0 [[159, 479]] 1.0 6a1f Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.3e-91 310.2 1 301 301 306 307 308 310 312 188 203 207 284 286 285 287 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK2 DYRK2_HUMAN 7DH9A Q92630 215 538 601.0 H7F:601 Type1 Inactive DFGin 6.955 15.393 BLAminus -118.25, -176.44 52.33, 72.66 -86.4, 22.32 285.5, 71.17 -68.46, -16.6 in-in in 9.091 Saltbr-in 2.818 HRD-in -67.52, -48.86 77.78, -1.22 in-in-out SNCiio in-out ActLoopNT-in 2.826 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.21, 165.64 APE9-dihe-na 77.26, 152.01 APE8-dihe-in -71.35, 136.19 APE8-rot-out 186.16 APE67-dihe-in -56.24, -27.47 -53.15, -48.91 APE12-dist-in 13.085 APE11-dist-in 11.935 APE10-dist-in 7.588 APE9-dist-in 3.308 None PTR382,SEP458 PTR382,SEP458 XRAY 2.194 0.19 0.218 A 324 324 0 0 0 0 [[222, 535]] 1.0 7dh9 Homo sapiens CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1 301 301 367 368 369 371 373 251 266 270 345 347 346 348 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
CMGC GSK3B GSK3B_HUMAN 9PE9A P49841 36 382 420.0 A1CIF:900 Type1 Inactive DFGin 7.072 14.229 BLAminus -128.7, -179.96 59.31, 84.1 -97.11, 26.91 283.64, 74.63 -73.69, -18.15 in-in in 8.351 Saltbr-in 2.725 HRD-in -68.62, -45.57 65.7, 16.55 in-in-out SNCiio in-out ActLoopNT-in 2.925 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -143.94, 165.33 APE9-dihe-na 76.34, 152.28 APE8-dihe-in -69.82, 130.62 APE8-rot-out 176.66 APE67-dihe-in -58.68, -26.71 -39.69, -56.4 APE12-dist-in 13.28 APE11-dist-in 11.758 APE10-dist-in 7.093 APE9-dist-in 3.155 None PTR216 PTR216 XRAY 2.11 0.221 0.247 A 359 332 13 0 0 0 [[56, 340]] 1.0 9pe9 Homo sapiens CMGC_GSK3B_HUMAN CMGC 2e-70 243.6 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 9PE9B P49841 36 382 420.0 A1CIF:900 Type1 Inactive DFGin 7.058 14.218 BLAminus -128.76, -179.81 59.6, 84.42 -97.78, 27.09 283.79, 74.38 -73.25, -17.71 in-in in 8.353 Saltbr-in 2.713 HRD-in -68.49, -44.82 64.55, 18.32 in-in-out SNCiio in-out ActLoopNT-in 2.94 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -144.27, 163.74 APE9-dihe-na 77.64, 152.05 APE8-dihe-in -69.14, 130.82 APE8-rot-out 177.12 APE67-dihe-in -58.92, -26.81 -39.96, -55.88 APE12-dist-in 13.36 APE11-dist-in 11.824 APE10-dist-in 7.161 APE9-dist-in 3.172 None PTR216 PTR216 XRAY 2.11 0.221 0.247 B 359 332 13 0 0 0 [[56, 340]] 1.0 9pe9 Homo sapiens CMGC_GSK3B_HUMAN CMGC 2e-70 243.6 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 4PTEA P49841 36 382 420.0 2WF:501 Type1 Active DFGin 6.932 14.017 BLAminus -141.21, 178.04 57.99, 89.39 -100.23, 24.26 286.38, 75.9 -68.08, -19.02 in-in in 8.716 Saltbr-in 2.635 HRD-in -73.56, -44.45 69.11, 4.74 in-in-in SNCiii in-in ActLoopNT-in 2.792 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.74, 175.98 APE9-dihe-na 75.98, 148.82 APE8-dihe-in -103.79, 152.51 APE8-rot-in 295.33 APE67-dihe-inflip 95.08, -28.26 -38.95, 126.56 APE12-dist-in 12.979 APE11-dist-in 10.89 APE10-dist-in 5.883 APE9-dist-in 3.088 None None None XRAY 2.033 0.17 0.195 A 441 341 6 0 0 0 [[56, 340]] 1.0 4pte Homo sapiens CMGC_GSK3B_HUMAN CMGC 3.7e-70 242.6 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 4PTEB P49841 36 385 420.0 2WF:501 Type1 Active DFGin 6.918 13.937 BLAminus -137.07, 179.43 58.52, 88.98 -101.38, 27.88 284.28, 76.88 -69.85, -20.65 in-in in 8.484 Saltbr-in 2.685 HRD-in -70.9, -46.61 73.05, 2.3 in-in-in SNCiii in-in ActLoopNT-in 2.887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -87.76, 178.59 APE9-dihe-na 72.73, 147.77 APE8-dihe-in -103.48, 150.66 APE8-rot-in 296.89 APE67-dihe-inflip 94.67, -27.57 -36.66, 125.81 APE12-dist-in 12.935 APE11-dist-in 10.88 APE10-dist-in 5.877 APE9-dist-in 3.154 None None None XRAY 2.033 0.17 0.195 B 441 347 3 0 0 0 [[56, 340]] 1.0 4pte Homo sapiens CMGC_GSK3B_HUMAN CMGC 3.7e-70 242.6 1 301 301 199 200 201 203 205 85 97 101 178 180 179 181 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC MAPK1 MK01_HUMAN 5BVDA P28482 9 358 360.0 4VF:60401 Type1 None DFGin 7.012 14.82 BLAminus -120.88, -174.96 58.49, 83.25 -99.87, 23.43 283.53, 71.8 -56.85, -34.73 in-in in 9.264 Saltbr-in 2.627 HRD-in -80.64, -49.81 78.16, -6.37 in-in-none SNCiin in-none ActLoopNT-in 2.72 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 122.19 APE8-rot-in 306.38 APE67-dihe-in -62.44, -24.22 -51.26, -49.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.172 0.207 A 361 330 20 0 0 16 [[25, 313]] 1.0 5bvd Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.2e-86 293.7 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8AO6A P28482 11 356 360.0 N9F:406 Type1 Inactive DFGin 6.771 16.337 BLAminus -129.81, 177.88 71.62, 78.81 -103.22, 23.44 283.23, 73.97 -64.0, -29.38 out-in out 10.371 Saltbr-in 2.597 HRD-in -72.45, -50.74 72.14, 4.83 in-in-out SNCiio in-out ActLoopNT-in 2.785 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -96.92, -36.24 APE9-dihe-na -66.98, 156.39 APE8-dihe-in -51.35, 125.27 APE8-rot-in 311.93 APE67-dihe-in -64.42, -17.18 -56.32, -47.54 APE12-dist-out 14.414 APE11-dist-in 11.107 APE10-dist-in 7.103 APE9-dist-in 4.264 None None CME127,CME161 XRAY 1.811 0.175 0.222 A 368 338 0 0 0 0 [[25, 313]] 1.0 8ao6 Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.9e-86 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8AO9A P28482 11 356 360.0 N4F:406 Type1 Inactive DFGin 6.837 16.45 BLAminus -129.5, 178.83 61.88, 81.37 -96.97, 21.21 286.14, 78.83 -59.7, -30.7 out-out out 10.301 Saltbr-out 3.765 HRD-in -72.95, -49.65 72.84, 3.98 out-in-out SNCoio in-out ActLoopNT-in 2.854 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -91.06, -44.4 APE9-dihe-na -60.28, 156.59 APE8-dihe-in -55.09, 130.24 APE8-rot-in 307.62 APE67-dihe-in -64.58, -17.09 -62.44, -44.52 APE12-dist-out 14.27 APE11-dist-in 10.981 APE10-dist-in 6.789 APE9-dist-in 4.23 None None CME161 XRAY 1.624 0.184 0.232 A 368 338 2 0 0 0 [[25, 313]] 1.0 8ao9 Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.9e-86 293.6 1 301 301 166 167 168 170 172 54 71 75 146 148 147 149 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK10 MK10_HUMAN 3CGFA P53779 45 400 464.0 JNF:523 Type1 Inactive DFGin 3.719 14.039 ABAminus -89.59, -53.32 -106.99, -179.49 -117.03, 20.53 309.75, 79.33 76.52, -162.79 in-out in 9.602 Saltbr-out 3.611 HRD-in -43.19, -70.09 72.17, 4.64 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -63.93, 178.32 APE9-dihe-na -126.54, 145.54 APE8-dihe-in -86.07, 133.09 APE8-rot-in 307.62 APE67-dihe-in -51.07, -34.7 -123.34, -6.64 APE12-dist-out 21.335 APE11-dist-out 17.893 APE10-dist-out 16.615 APE9-dist-out 11.474 None None None XRAY 3.0 0.225 0.317 A 365 346 5 0 0 5 [[64, 359]] 1.0 3cgf Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 7YL1A P53779 45 400 464.0 J6F:501 Type1 Inactive DFGin 3.995 14.06 ABAminus -80.16, -27.18 -141.36, 174.64 -114.52, 17.98 302.24, 85.17 76.51, -161.32 in-in in 9.23 Saltbr-in 2.755 HRD-in -85.09, -59.15 76.16, -2.31 in-out-out SNCioo out-out ActLoopNT-out 6.441 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -89.31, 134.84 APE9-dihe-na -84.54, 138.55 APE8-dihe-in -77.28, 127.44 APE8-rot-in 291.87 APE67-dihe-in -54.76, -19.99 -106.7, -13.11 APE12-dist-out 20.721 APE11-dist-out 15.877 APE10-dist-out 16.196 APE9-dist-out 11.273 None None None XRAY 2.48 0.208 0.294 A 464 352 2 0 0 2 [[64, 359]] 1.0 7yl1 Homo sapiens CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1 301 301 206 207 208 210 212 93 111 115 186 188 187 189 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK14 MK14_HUMAN 6ZQSA Q16539 4 353 360.0 3FF:400 Type1 Inactive DFGin 7.131 15.007 BLAminus -100.05, 172.92 58.72, 89.64 -100.69, 26.63 286.71, 76.86 -66.14, -26.38 out-out out 10.282 Saltbr-out 3.92 HRD-in -83.97, -53.39 74.81, 10.18 out-in-in SNCoii in-in ActLoopNT-in 2.855 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.23, 173.02 APE9-dihe-na 73.87, 161.94 APE8-dihe-in -91.46, 139.33 APE8-rot-in 294.96 APE67-dihe-in -66.05, -18.45 -53.95, -45.87 APE12-dist-in 11.599 APE11-dist-in 11.174 APE10-dist-in 6.771 APE9-dist-in 3.046 None TPO180,PTR182 TPO180,PTR182 XRAY 1.95 0.178 0.223 A 362 350 0 0 0 0 [[24, 308]] 1.0 6zqs Homo sapiens CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 5XYYA Q16539 4 352 360.0 P0F:401 Type1.5_Back Inactive DFGin 8.144 16.25 BLBminus -111.25, 174.05 61.59, 81.71 -109.03, 145.8 286.82, 89.51 69.26, 21.62 in-in in 8.942 Saltbr-in 2.649 HRD-in -68.14, -52.86 82.9, -10.64 in-out-out SNCioo out-out ActLoopNT-out 11.476 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.86, 131.59 APE9-dihe-na -62.4, -17.36 APE8-dihe-out -62.41, -19.09 APE8-rot-out 53.75 APE67-dihe-in -64.55, -20.22 -114.48, -18.89 APE12-dist-out 21.139 APE11-dist-out 22.895 APE10-dist-out 17.093 APE9-dist-out 11.759 None None None XRAY 1.7 0.18 0.201 A 380 343 6 0 0 0 [[24, 308]] 1.0 5xyy Homo sapiens CMGC_MAPK14_HUMAN CMGC 7e-85 290.9 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 2QD9A Q16539 5 352 360.0 LGF:361 Type1 Inactive DFGin 5.134 13.797 BLBplus -108.86, 148.96 74.79, 24.8 -73.05, 150.79 49.54, 82.76 82.07, 6.15 in-in in 9.155 Saltbr-in 2.557 HRD-in -76.06, -55.95 78.8, -20.76 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -59.56, -22.52 999.0, -59.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.252 0.282 A 366 330 18 0 0 13 [[24, 308]] 1.0 2qd9 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3QUDA Q16539 4 354 360.0 N3F:361 Type1 Inactive DFGin 10.801 12.553 None -93.66, 153.34 -68.51, -47.3 -136.82, 128.38 301.98, 103.1 -95.02, -166.54 in-in in 9.269 Saltbr-in 3.555 HRD-in -63.42, -58.28 80.41, -12.58 in-out-out SNCioo out-out ActLoopNT-out 20.801 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 112.75 APE9-dihe-na -76.37, 136.79 APE8-dihe-out -65.47, -38.0 APE8-rot-in 295.71 APE67-dihe-in -57.05, -26.46 -56.48, -28.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.762 APE9-dist-out 12.652 None None None XRAY 2.0 0.234 0.278 A 360 345 6 0 0 6 [[24, 308]] 1.0 3qud Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3QUEA Q16539 5 353 360.0 3FF:362 Type1 Inactive DFGin 10.642 12.339 None -82.41, 155.86 -75.27, -54.23 -130.98, 134.23 308.77, 88.25 -97.08, -170.31 in-in in 8.96 Saltbr-in 2.657 HRD-in -64.83, -54.13 86.66, -27.06 in-out-out SNCioo out-out ActLoopNT-out 21.279 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 66.84 APE9-dihe-na -77.78, 135.56 APE8-dihe-out -48.89, -54.16 APE8-rot-in 280.74 APE67-dihe-in -53.38, -25.8 -51.95, -34.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.195 APE9-dist-out 11.393 None None None XRAY 2.7 0.23 0.311 A 360 343 6 0 0 6 [[24, 308]] 1.0 3que Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4R3CA Q16539 4 352 360.0 3GF:402,3GF:403 Type1,Allosteric Inactive DFGin 4.924 13.134 None -118.67, 171.2 49.4, 42.48 -86.86, 999.0 38.51, 75.43 999.0, 999.0 in-out in 9.543 Saltbr-out 3.908 HRD-in -66.01, -56.32 81.1, -14.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 103.85 APE9-dihe-na -65.1, 130.86 APE8-dihe-out -51.86, -39.46 APE8-rot-in 289.55 APE67-dihe-in -62.53, -25.36 -48.44, -37.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.264 None None CME162 XRAY 2.06 0.178 0.217 A 383 336 13 0 0 13 [[24, 308]] 1.0 4r3c Homo sapiens CMGC_MAPK14_HUMAN CMGC 7.2e-85 290.9 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3L8SA Q16539 4 353 360.0 BFF:361 Type1 Inactive DFGout 15.489 11.977 None -119.54, 162.4 -99.13, -16.66 31.92, 999.0 247.73, 144.9 999.0, 999.0 in-in in 9.497 Saltbr-in 2.817 HRD-in -77.51, -50.13 90.87, -25.05 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 107.11 APE9-dihe-na -94.83, 118.78 APE8-dihe-out -62.16, -3.07 APE8-rot-out 173.18 APE67-dihe-in -59.13, -22.21 -95.45, -15.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.2 C119S,C162S,A172C,F327L None None XRAY 2.35 0.242 0.307 A 360 334 16 0 0 13 [[24, 308]] 1.0 3l8s Homo sapiens CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3UVRA Q16539 5 351 360.0 06F:361 Type2 Inactive DFGout 15.561 8.524 None -148.63, 178.6 -133.58, 101.18 -90.01, -1.78 195.55, 17.77 -54.07, 127.45 in-in in 8.211 Saltbr-in 2.627 HRD-in -62.71, -55.49 83.79, -17.62 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -56.89 APE8-dihe-out -51.15, -30.26 APE8-rot-in 300.71 APE67-dihe-in -70.54, -25.21 -93.95, -15.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.621 None None None XRAY 2.1 0.204 0.245 A 360 331 16 0 0 12 [[24, 308]] 1.0 3uvr Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK8 MK08_HUMAN 8PTAA P45983 8 363 427.0 CIF:401 Type1 Inactive DFGin 3.923 14.477 ABAminus -80.58, -61.37 -103.85, 165.38 -100.79, 23.99 295.77, 91.74 73.84, -149.47 in-in in 9.79 Saltbr-in 3.126 HRD-in -78.59, -61.53 62.23, 7.12 in-out-out SNCioo out-out ActLoopNT-out 6.47 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -130.45, 138.38 APE9-dihe-na -101.99, 109.25 APE8-dihe-in -118.89, 112.23 APE8-rot-out 53.5 APE67-dihe-in -51.79, -30.07 -95.29, -17.54 APE12-dist-in 10.569 APE11-dist-out 7.033 APE10-dist-out 10.183 APE9-dist-out 8.598 None None None XRAY 2.41 0.224 0.226 A 366 354 2 0 0 2 [[26, 321]] 1.0 8pta Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 8PTAB P45983 7 363 427.0 CIF:401 Type1 Inactive DFGin 3.577 13.179 ABAminus -81.24, -57.35 -101.3, 158.61 -105.36, 14.2 308.93, 93.28 64.59, -148.13 in-in in 9.366 Saltbr-in 3.536 HRD-in -77.41, -61.25 61.49, 9.23 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -112.33, 168.25 APE9-dihe-na -116.9, 36.67 APE8-dihe-in -104.63, 91.0 APE8-rot-out 52.55 APE67-dihe-in -56.88, -29.41 -95.02, -21.65 APE12-dist-in 11.784 APE11-dist-in 9.152 APE10-dist-out 11.242 APE9-dist-out 10.214 None None None XRAY 2.41 0.224 0.226 B 366 352 5 0 0 5 [[26, 321]] 1.0 8pta Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 8PTAC P45983 8 361 427.0 CIF:401 Type1 Inactive DFGin 3.826 14.088 ABAminus -83.97, -56.35 -97.04, 154.46 -105.76, 13.83 294.99, 32.04 63.79, -147.27 in-out in 9.723 Saltbr-out 4.528 HRD-in -77.01, -60.9 63.25, 7.56 out-out-out SNCooo out-out ActLoopNT-out 4.611 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -137.59 APE9-dihe-na -94.11, 17.64 APE8-dihe-in -81.48, 63.35 APE8-rot-out 71.39 APE67-dihe-in -58.68, -26.77 -108.19, -24.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.467 APE9-dist-out 10.78 None None None XRAY 2.41 0.224 0.226 C 366 351 3 0 0 3 [[26, 321]] 1.0 8pta Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK9 MK09_HUMAN 3E7OA P45984 9 361 424.0 35F:1 Type1 Inactive DFGin 4.266 14.526 ABAminus -84.35, -29.35 -149.55, 177.24 -106.27, 9.79 301.22, 95.14 60.95, -143.01 in-in in 9.439 Saltbr-in 2.686 HRD-in -64.97, -51.12 67.58, -6.1 in-out-out SNCioo out-out ActLoopNT-out 5.519 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -84.71, -45.82 APE9-dihe-na -76.84, -178.43 APE8-dihe-in -88.6, 137.99 APE8-rot-in 266.04 APE67-dihe-out -72.72, -13.34 -138.1, 64.96 APE12-dist-out 20.29 APE11-dist-out 15.686 APE10-dist-out 19.328 APE9-dist-out 14.665 C177S,C222S,K250A,K251A,K265A,K270A None None XRAY 2.14 0.219 0.25 A 360 342 2 0 0 0 [[26, 321]] 1.0 3e7o Homo sapiens CMGC_MAPK9_HUMAN CMGC 2.7e-84 288.8 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 9
CMGC MAPK9 MK09_HUMAN 3E7OB P45984 8 362 424.0 35F:2 Type1 Inactive DFGin 4.276 14.318 ABAminus -85.32, -37.61 -133.45, 175.33 -107.39, 15.94 299.45, 88.14 90.36, 999.0 in-in in 9.466 Saltbr-in 2.801 HRD-in -71.07, -57.75 72.11, -12.31 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -39.52 APE8-rot-out 181.64 APE67-dihe-in -65.99, -17.44 -49.19, -35.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C177S,C222S,K250A,K251A,K265A,K270A None None XRAY 2.14 0.219 0.25 B 360 326 19 0 0 16 [[26, 321]] 1.0 3e7o Homo sapiens CMGC_MAPK9_HUMAN CMGC 2.7e-84 288.8 1 301 301 168 169 170 172 174 55 73 77 148 150 149 151 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 9
OTHER CDC7 CDC7_HUMAN 6YA8A O00311 38 572 574.0 ADP:60601,BEF:60603 ATPlike,Allosteric None DFGin 6.168 14.087 BLAminus -118.93, 173.08 76.34, 83.66 -102.33, 21.87 291.62, 81.2 -67.07, -22.7 in-in in 8.709 Saltbr-in 2.738 HRD-in -65.76, -44.2 72.35, -4.4 in-in-none SNCiin in-none ActLoopNT-in 2.755 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na -83.06, -154.71 APE8-dihe-in -48.63, 132.1 APE8-rot-in 306.86 APE67-dihe-in -66.07, -7.37 -59.08, -35.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.888 None None None XRAY 1.79 0.167 0.197 A 359 338 13 0 0 13 [[58, 569]] 1.0 6ya8 Homo sapiens OTHER_CDC7_HUMAN CMGC 2e-18 137.3 1 161 296 195 196 197 199 201 90 104 108 174 176 175 177 396 383 378 377 376 375 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER GAK GAK_HUMAN 4C57A O14976 25 334 1311.0 FEF:1340 Type1 Inactive DFGin 5.754 14.141 ABAminus -112.53, -37.31 -102.07, 134.52 -132.21, 22.67 297.88, 98.14 -59.75, -31.11 in-out in 9.993 Saltbr-out 4.057 HRD-in -62.14, -51.36 70.7, -5.09 out-in-in SNCoii in-in ActLoopNT-in 2.895 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.34, 3.52 APE9-dihe-na -124.99, 156.99 APE8-dihe-in -84.98, 122.71 APE8-rot-in 297.75 APE67-dihe-in -71.57, -19.62 -46.23, -44.89 APE12-dist-in 11.779 APE11-dist-in 8.573 APE10-dist-in 4.33 APE9-dist-in 4.07 None None None XRAY 2.55 0.18 0.228 A 340 310 0 0 0 0 [[40, 313]] 1.0 4c57 Homo sapiens OTHER_GAK_HUMAN CAMK 5.3e-44 156.7 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 4C57B O14976 27 334 1311.0 FEF:1337 Type1 Inactive DFGin 5.769 14.233 ABAminus -105.07, -37.59 -101.51, 133.86 -130.57, 22.88 297.9, 97.48 -60.27, -26.81 out-out out 10.065 Saltbr-out 4.056 HRD-in -62.14, -52.49 71.3, -9.85 out-in-in SNCoii in-in ActLoopNT-in 2.891 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.07, 5.67 APE9-dihe-na -124.2, 156.66 APE8-dihe-in -83.72, 121.96 APE8-rot-in 296.0 APE67-dihe-in -71.56, -19.42 -45.7, -45.17 APE12-dist-in 11.928 APE11-dist-in 8.658 APE10-dist-in 4.358 APE9-dist-in 4.086 None None None XRAY 2.55 0.18 0.228 B 340 308 0 0 0 0 [[40, 313]] 1.0 4c57 Homo sapiens OTHER_GAK_HUMAN CAMK 5.3e-44 156.7 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 4C59A O14976 27 333 1311.0 FEF:1334 Type1 Inactive DFGin 5.815 13.68 ABAminus -134.62, -10.32 -105.18, 88.43 -107.04, 23.92 300.54, 105.0 -81.95, -10.0 in-in in 9.093 Saltbr-in 2.855 HRD-in -82.36, -54.36 82.63, -15.13 in-in-none SNCiin in-none ActLoopNT-in 2.838 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.205 0.262 A 340 266 41 0 0 27 [[40, 313]] 1.0 4c59 Homo sapiens OTHER_GAK_HUMAN CAMK 5.3e-44 156.7 3 252 250 190 191 192 194 196 69 85 89 170 172 171 173 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER HASPIN HASP_HUMAN 9FLTA Q8TF76 471 798 798.0 A1IDF:801 Type1 Active DFGin 5.178 12.218 BLAminus -141.02, 178.95 59.99, 70.73 -81.95, 27.03 316.78, 141.24 -69.29, -28.67 in-in in 8.759 Saltbr-in 2.463 HRD-na-N -66.6, -53.16 75.71, 6.9 in-in-na SNCiia in-na ActLoopNT-in 2.905 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -131.58, 41.34 APE9-dihe-na -102.69, 164.5 APE8-dihe-na -162.68, -171.46 APE8-rot-na 41.52 APE67-dihe-na -134.91, 146.64 100.36, -24.97 APE12-dist-na 9.64 APE11-dist-na 13.509 APE10-dist-na 17.247 APE9-dist-na 13.279 None None None XRAY 2.4 0.187 0.239 A 336 320 8 0 0 0 [[484, 797]] 1.0 9flt Homo sapiens OTHER_HASPIN_HUMAN HASP 1.1e-226 756.9 1 314 314 686 687 688 690 692 511 535 539 646 648 647 649 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER TTK TTK_HUMAN 4JS8A P33981 515 793 857.0 1PF:801 Type1 Inactive DFGin 4.246 15.018 ABAminus -84.57, -49.34 -133.98, 167.4 -109.17, 14.51 305.07, 151.28 67.69, 15.63 in-out in 9.993 Saltbr-out 6.699 HRD-in -62.96, -52.34 70.46, -10.5 out-out-out SNCooo out-out ActLoopNT-out 12.036 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnoo APE10-dihe-na 999.0, 112.01 APE9-dihe-na -104.69, -175.56 APE8-dihe-in -119.7, 153.55 APE8-rot-none 999.0 APE67-dihe-in -65.36, -29.34 -115.57, 0.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.198 APE9-dist-out 12.111 None TPO675,TPO686 TPO675,TPO686 XRAY 1.94 0.232 0.253 A 281 261 18 0 0 8 [[525, 791]] 1.0 4js8 Homo sapiens OTHER_TTK_HUMAN CAMK 5.6e-54 189.1 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 7CHMA P33981 516 794 857.0 FZF:801 Type1 Inactive DFGin 4.413 14.608 None -111.88, -71.82 -63.89, 158.67 -119.5, 9.1 283.45, 179.72 82.92, -15.75 in-in in 9.56 Saltbr-in 3.396 HRD-in -57.59, -51.23 60.31, 6.24 in-out-out SNCioo out-out ActLoopNT-out 12.264 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, -62.47 APE9-dihe-na 66.11, 172.68 APE8-dihe-out -121.28, -175.85 APE8-rot-none 999.0 APE67-dihe-in -54.56, -33.62 -132.81, 0.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.863 APE9-dist-out 12.904 None TPO675,TPO686 TPO675,TPO686 XRAY 2.65 0.212 0.253 A 281 260 19 0 0 8 [[525, 791]] 1.0 7chm Homo sapiens OTHER_TTK_HUMAN CAMK 5.6e-54 189.1 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER ULK1 ULK1_HUMAN 4WNOA O75385 8 280 1050.0 3RF:401 Type1 Active DFGin 6.889 14.949 BLAminus -117.94, 169.26 64.81, 74.6 -94.14, 20.86 282.18, 71.59 -63.55, -24.11 in-in in 7.662 Saltbr-in 2.77 HRD-in -82.57, -51.36 80.06, -2.07 in-in-in SNCiii in-in ActLoopNT-in 2.966 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.03, 162.62 APE9-dihe-na 120.91, -162.5 APE8-dihe-in -119.54, 124.2 APE8-rot-in 305.96 APE67-dihe-in -67.71, -19.19 -53.63, -37.75 APE12-dist-in 8.214 APE11-dist-in 11.212 APE10-dist-in 5.675 APE9-dist-in 3.309 E37A,K38A TPO180 TPO180 XRAY 1.56 0.18 0.208 A 287 273 0 0 0 0 [[14, 278]] 1.0 4wno Homo sapiens OTHER_ULK1_HUMAN ULK 2.1e-132 446.2 1 256 256 164 165 166 168 170 46 63 67 135 137 136 138 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
STE MAP2K1 MP2K1_HUMAN 7UMBC Q02750 41 381 393.0 ANP:401,U9F:402 ATPlike,Type3 Inactive DFGin 6.169 13.767 BLBplus -162.24, 171.11 70.21, 49.7 -113.95, 160.88 44.65, 94.08 -79.06, 81.13 out-out out 15.559 Saltbr-out 15.273 HRD-in -66.12, -48.09 76.83, -9.86 out-out-out SNCooo out-out ActLoopNT-out 9.591 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -127.94, 139.36 APE9-dihe-na -138.86, -160.81 APE8-dihe-out -82.2, -18.64 APE8-rot-out 50.9 APE67-dihe-out -106.39, 139.13 -104.8, 110.61 APE12-dist-out 16.699 APE11-dist-out 19.666 APE10-dist-out 21.57 APE9-dist-out 14.915 None None None XRAY 3.231 0.231 0.268 C 384 303 38 0 0 0 [[68, 361]] 1.0 7umb Homo sapiens STE_MAP2K1_HUMAN STE 2.3e-97 331.4 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K7 MP2K7_HUMAN 6YG3A O14733 103 400 419.0 6HF:60510 Type1 None DFGin 6.195 14.549 BLAminus -146.55, 178.23 54.3, 83.97 -103.73, 30.03 316.89, 91.95 -57.17, -29.89 na-na na 8.345 Saltbr-na 3.36 HRD-in -81.36, -52.29 76.4, 12.98 na-in-none SNCain in-none ActLoopNT-in 2.982 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.05 0.191 0.235 A 307 265 33 0 0 19 [[120, 380]] 1.0 6yg3 Homo sapiens STE_MAP2K7_HUMAN STE 2.4e-80 275.5 2 257 256 260 261 262 264 266 149 166 170 240 242 241 243 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
STE MAP4K1 M4K1_HUMAN 8FH4A Q92918 4 293 833.0 XXF:60401 Type1 Inactive DFGin 6.846 14.475 BLAminus -131.99, 171.23 62.34, 86.7 -92.12, 20.1 289.3, 88.42 -59.7, -48.05 in-in in 9.232 Saltbr-in 2.734 HRD-in -67.47, -51.18 67.4, 4.94 in-out-out SNCioo out-out ActLoopNT-out 6.199 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -73.65, -44.57 APE9-dihe-na 76.29, -171.23 APE8-dihe-in -62.48, 141.12 APE8-rot-out 34.25 APE67-dihe-in -59.58, -27.68 -102.29, 0.49 APE12-dist-out 20.304 APE11-dist-out 21.079 APE10-dist-out 21.421 APE9-dist-out 27.259 T165E,S171E None None XRAY 1.827 0.189 0.215 A 331 290 0 0 0 0 [[17, 274]] 1.0 8fh4 Homo sapiens STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FH4B Q92918 6 302 833.0 XXF:60402 Type1 Inactive DFGin 6.551 14.294 BLAminus -141.43, 174.43 62.64, 85.33 -93.2, 13.55 285.99, 85.49 -57.34, -45.75 in-in in 8.939 Saltbr-in 2.697 HRD-in -67.85, -50.88 67.73, 2.48 in-out-out SNCioo out-out ActLoopNT-out 6.309 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -67.39, -32.57 APE9-dihe-na 75.42, -167.37 APE8-dihe-in -61.44, 126.8 APE8-rot-out 59.49 APE67-dihe-in -56.24, -30.95 -97.05, -0.91 APE12-dist-out 19.464 APE11-dist-out 20.586 APE10-dist-out 21.665 APE9-dist-out 28.047 T165E,S171E None None XRAY 1.827 0.189 0.215 B 331 297 0 0 0 0 [[17, 274]] 1.0 8fh4 Homo sapiens STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FH4C Q92918 1 292 833.0 XXF:60401 Type1 Inactive DFGin 6.824 14.118 BLAminus -136.31, 172.65 64.01, 85.1 -95.02, 19.77 288.84, 83.7 -61.21, -46.39 in-in in 8.967 Saltbr-in 2.733 HRD-in -69.91, -50.19 67.9, 0.86 in-out-out SNCioo out-out ActLoopNT-out 6.08 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -67.7, -68.85 APE9-dihe-na -109.26, -27.15 APE8-dihe-in -115.11, 101.44 APE8-rot-out 62.11 APE67-dihe-in -65.51, -20.35 -96.81, 16.0 APE12-dist-out 19.318 APE11-dist-out 20.935 APE10-dist-out 23.085 APE9-dist-out 28.365 T165E,S171E None None XRAY 1.827 0.189 0.215 C 331 292 0 0 0 0 [[17, 274]] 1.0 8fh4 Homo sapiens STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FH4D Q92918 8 292 833.0 XXF:60401 Type1 Inactive DFGin 6.646 14.023 BLAminus -135.73, 170.9 66.66, 83.46 -93.58, 25.1 289.61, 94.72 -69.05, -41.66 in-in in 9.022 Saltbr-in 2.745 HRD-in -74.6, -51.27 71.89, -5.96 in-out-out SNCioo out-out ActLoopNT-out 6.134 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -170.02 APE8-dihe-in -67.05, 131.5 APE8-rot-out 192.16 APE67-dihe-in -57.98, -30.82 -102.78, -3.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 27.427 T165E,S171E None None XRAY 1.827 0.189 0.215 D 331 276 9 0 0 4 [[17, 274]] 1.0 8fh4 Homo sapiens STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9QT6A Q92918 6 292 833.0 A1JAF:301 Type1 Inactive DFGin 6.463 13.765 None -60.93, -35.58 -154.04, -176.9 -79.86, 1.42 63.88, 19.01 105.02, -157.57 out-out out 13.28 Saltbr-out 10.782 HRD-in -74.09, -55.53 70.27, 5.38 out-out-out SNCooo out-out ActLoopNT-out 7.582 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -59.89, -40.77 APE9-dihe-na -92.18, -16.28 APE8-dihe-in -142.86, 74.69 APE8-rot-in 316.27 APE67-dihe-in -56.11, -27.62 -91.41, -1.8 APE12-dist-in 9.809 APE11-dist-in 11.134 APE10-dist-out 15.153 APE9-dist-out 12.698 T165E,S171E None None XRAY 1.76 0.198 0.226 A 294 285 2 0 0 0 [[17, 274]] 1.0 9qt6 Homo sapiens STE_MAP4K1_HUMAN STE 4.1e-92 314.1 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8CIJA Q92918 14 294 833.0 USF:401 Type1 Inactive DFGout 11.213 7.331 None -112.58, 122.54 -96.1, 115.56 -121.01, 999.0 297.98, 106.95 999.0, 999.0 out-out out 13.535 Saltbr-out 11.8 HRD-in -61.67, -48.53 69.18, 2.25 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na -87.98, 122.06 APE9-dihe-na 145.78, 142.84 APE8-dihe-in -120.8, 116.13 APE8-rot-in 320.07 APE67-dihe-in -58.16, -27.75 -31.5, -57.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.681 None None None XRAY 2.821 0.239 0.266 A 307 264 17 0 0 12 [[17, 274]] 1.0 8cij Homo sapiens STE_MAP4K1_HUMAN STE 4.8e-92 313.9 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K4 M4K4_HUMAN 5DI1A O95819 13 309 1239.0 5DF:4000 Type1 Inactive DFGin 4.26 13.366 BLBplus -145.12, 159.02 72.53, 52.2 -89.55, 138.32 48.51, 95.38 -80.62, 999.0 in-out in 9.403 Saltbr-out 3.985 HRD-in -61.2, -47.09 79.65, -23.06 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -102.21, 124.07 APE9-dihe-na -81.57, -147.04 APE8-dihe-in -74.95, 131.45 APE8-rot-out 195.98 APE67-dihe-in -46.35, -33.38 -85.44, -21.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.602 None None None XRAY 2.9 0.2 0.249 A 310 285 12 0 0 12 [[25, 289]] 1.0 5di1 Homo sapiens STE_MAP4K4_HUMAN STE 1.3e-102 348.4 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
TKL ACVR1 ACVR1_HUMAN 3MTFA Q04771 203 498 509.0 A3F:1 Type1 Inactive DFGin 7.09 13.208 BLAminus -126.1, 157.67 76.9, 82.69 -86.05, 21.36 306.23, 175.03 -61.66, -24.97 in-out in 8.331 Saltbr-out 4.196 HRD-in -82.54, -58.57 79.29, -1.49 out-in-out SNCoio in-out ActLoopNT-in 2.913 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -103.22, 162.67 APE9-dihe-na -69.88, 165.81 APE8-dihe-in -53.93, 121.99 APE8-rot-in 312.82 APE67-dihe-in -59.42, -28.32 -57.34, -37.41 APE12-dist-in 10.671 APE11-dist-out 6.476 APE10-dist-out 9.482 APE9-dist-in 4.073 Q207D None None XRAY 2.15 0.185 0.244 A 301 296 0 0 0 0 [[207, 497]] 1.0 3mtf Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 3MTFB Q04771 202 499 509.0 A3F:501 Type1 Inactive DFGin 7.578 13.323 BLAminus -114.45, 160.06 82.35, 87.49 -104.83, 25.86 291.12, 164.81 -75.29, -13.54 in-out in 8.5 Saltbr-out 4.232 HRD-in -82.5, -60.12 85.3, -4.39 out-in-out SNCoio in-out ActLoopNT-in 2.869 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -111.75, 153.3 APE9-dihe-na -57.45, 170.81 APE8-dihe-in -65.39, 131.64 APE8-rot-in 306.28 APE67-dihe-in -49.77, -35.33 -68.1, -43.23 APE12-dist-in 10.611 APE11-dist-out 6.453 APE10-dist-out 9.396 APE9-dist-in 4.119 Q207D None None XRAY 2.15 0.185 0.244 B 301 298 0 0 0 0 [[207, 497]] 1.0 3mtf Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 6EIXA Q04771 192 503 509.0 A3F:601 Type1 Inactive DFGin 7.305 13.382 BLAminus -122.31, 163.89 74.01, 85.68 -98.53, 23.31 310.02, 174.96 -66.89, -23.04 in-out in 9.083 Saltbr-out 5.16 HRD-in -81.6, -53.66 78.97, -2.54 out-in-out SNCoio in-out ActLoopNT-in 3.023 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -113.45, 165.41 APE9-dihe-na -59.94, 163.8 APE8-dihe-in -59.76, 126.51 APE8-rot-in 307.55 APE67-dihe-in -58.05, -30.26 -58.58, -41.78 APE12-dist-in 10.589 APE11-dist-out 6.415 APE10-dist-out 9.311 APE9-dist-in 3.871 Q207E None None XRAY 2.3 0.191 0.249 A 340 312 0 0 0 0 [[207, 497]] 1.0 6eix Homo sapiens TKL_ACVR1_HUMAN TKL 2.9e-85 292.0 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 8PODA Q04771 172 498 509.0 7IO:60501,F:60502 Type1,Allosteric Inactive DFGin 7.181 13.248 BLAminus -129.23, 172.96 64.95, 88.23 -102.11, 21.22 307.17, 178.99 -69.46, -24.05 in-out in 8.75 Saltbr-out 5.24 HRD-in -77.46, -49.01 73.0, -1.63 out-in-out SNCoio in-out ActLoopNT-in 3.105 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -104.74, 151.99 APE9-dihe-na -69.89, 170.49 APE8-dihe-in -67.7, 124.46 APE8-rot-in 304.29 APE67-dihe-in -63.94, -28.35 -69.6, -32.91 APE12-dist-in 10.74 APE11-dist-out 6.542 APE10-dist-out 9.732 APE9-dist-in 4.647 None None None XRAY 2.59 0.236 0.255 A 330 320 1 0 0 0 [[207, 497]] 1.0 8pod Homo sapiens TKL_ACVR1_HUMAN TKL 2.6e-85 292.1 2 267 266 353 354 355 357 359 235 248 252 333 335 334 336 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL BRAF BRAF_HUMAN 4YHTA P15056 449 719 766.0 4EF:61002 Type1 Inactive DFGin 6.44 13.919 BLAminus -130.91, -175.71 59.89, 88.64 -101.88, 16.92 281.61, 73.69 -54.19, -26.07 in-in in 8.608 Saltbr-in 2.731 HRD-in -63.73, -42.35 62.62, 3.64 in-in-out SNCiio in-out ActLoopNT-in 2.881 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -6.83 APE8-dihe-in -100.18, 82.06 APE8-rot-in 287.27 APE67-dihe-in -63.55, -16.06 -74.16, -21.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.11 I543T,I544N,I551T,L706T,L716T None None XRAY 3.05 0.2 0.233 A 272 256 15 0 0 13 [[457, 716]] 1.0 4yht Homo sapiens TKL_BRAF_HUMAN TKL 2.7e-84 288.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 4YHTB P15056 449 720 766.0 4EF:60802 Type1 Inactive DFGin 6.405 13.921 BLAminus -128.69, -172.56 54.11, 90.89 -102.92, 13.66 281.86, 71.12 -49.43, -28.96 in-in in 8.583 Saltbr-in 2.701 HRD-in -63.82, -42.99 62.91, 4.22 in-in-out SNCiio in-out ActLoopNT-in 2.864 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -6.59 APE8-dihe-in -97.87, 80.96 APE8-rot-in 285.28 APE67-dihe-in -62.85, -18.47 -75.71, -20.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.034 I543T,I544N,I551T,L706T,L716T None None XRAY 3.05 0.2 0.233 B 272 258 14 0 0 12 [[457, 716]] 1.0 4yht Homo sapiens TKL_BRAF_HUMAN TKL 2.7e-84 288.8 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 3Q96A P15056 449 722 766.0 0NF:1 Type2 Inactive DFGout 12.887 10.676 BBAminus -160.13, -172.44 -118.2, 91.86 -79.01, 12.35 294.04, 84.62 -59.8, 141.31 in-in in 8.392 Saltbr-in 2.855 HRD-in -57.31, -47.78 82.12, -11.82 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -115.71 APE8-rot-in 265.02 APE67-dihe-in -61.58, -24.04 -87.09, -36.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.1 0.233 0.288 A 282 253 21 0 0 18 [[457, 716]] 1.0 3q96 Homo sapiens TKL_BRAF_HUMAN TKL 8e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 3Q96B P15056 449 720 766.0 0NF:1 Type2 Inactive DFGout 12.338 11.655 BBAminus -159.06, -168.23 -117.43, 81.54 -79.68, 17.57 296.0, 82.29 -26.83, 105.54 in-in in 8.586 Saltbr-in 3.176 HRD-in -76.92, -42.58 73.28, -12.97 in-out-out SNCioo out-out ActLoopNT-out 18.49 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 159.44 APE8-dihe-in -92.55, 126.53 APE8-rot-in 290.06 APE67-dihe-in -62.77, -20.3 -102.35, -28.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.232 None None None XRAY 3.1 0.233 0.288 B 282 262 10 0 0 10 [[457, 716]] 1.0 3q96 Homo sapiens TKL_BRAF_HUMAN TKL 8e-82 280.7 4 266 263 593 594 595 597 599 483 501 505 573 575 574 576 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL IRAK4 IRAK4_HUMAN 4YP8A Q9NWZ3 164 459 460.0 4GF:501 Type1 Active DFGin 6.842 14.163 BLAminus -130.64, 178.89 61.7, 76.88 -103.53, 25.67 310.66, 96.36 -67.74, -31.55 in-in in 8.778 Saltbr-in 3.549 HRD-in -57.79, -50.73 76.7, -3.88 in-in-in SNCiii in-in ActLoopNT-in 2.775 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.21, 150.97 APE9-dihe-na 140.01, -173.97 APE8-dihe-in -103.61, 115.43 APE8-rot-in 309.9 APE67-dihe-in -66.28, -16.88 -42.43, -50.13 APE12-dist-in 10.008 APE11-dist-in 11.614 APE10-dist-in 6.326 APE9-dist-in 3.918 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 A 301 287 9 0 0 4 [[183, 456]] 1.0 4yp8 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4YP8B Q9NWZ3 161 459 460.0 4GF:501 Type1 Inactive DFGin 6.917 14.444 BLAminus -129.86, 179.56 60.17, 77.95 -104.22, 26.32 310.53, 95.0 -66.78, -33.18 in-out in 8.685 Saltbr-out 3.962 HRD-in -57.85, -50.75 76.66, -4.15 out-in-in SNCoii in-in ActLoopNT-in 2.853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.74, 150.82 APE9-dihe-na 140.12, -173.75 APE8-dihe-in -103.4, 115.49 APE8-rot-in 310.63 APE67-dihe-in -65.34, -17.03 -41.64, -51.23 APE12-dist-in 10.045 APE11-dist-in 11.581 APE10-dist-in 6.319 APE9-dist-in 3.905 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 B 301 281 18 0 0 6 [[183, 456]] 1.0 4yp8 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4YP8C Q9NWZ3 164 460 460.0 4GF:501 Type1 Inactive DFGin 6.821 14.409 BLAminus -129.81, 179.51 59.35, 79.05 -103.24, 26.6 309.61, 96.69 -66.38, -34.02 in-out in 8.851 Saltbr-out 4.684 HRD-in -59.31, -50.52 77.45, -5.42 out-in-in SNCoii in-in ActLoopNT-in 2.789 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.88, 150.51 APE9-dihe-na 141.79, -174.18 APE8-dihe-in -103.25, 114.63 APE8-rot-in 311.45 APE67-dihe-in -64.61, -17.76 -41.38, -51.75 APE12-dist-in 10.149 APE11-dist-in 11.626 APE10-dist-in 6.34 APE9-dist-in 3.945 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 C 301 290 7 0 0 4 [[183, 456]] 1.0 4yp8 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4YP8D Q9NWZ3 164 459 460.0 4GF:501 Type1 Inactive DFGin 6.854 14.319 BLAminus -129.62, 178.91 61.84, 77.53 -103.67, 26.43 310.15, 95.74 -66.28, -34.21 in-out in 8.915 Saltbr-out 3.802 HRD-in -59.75, -49.91 75.93, -3.95 out-in-in SNCoii in-in ActLoopNT-in 2.79 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.59, 153.02 APE9-dihe-na 138.42, -174.86 APE8-dihe-in -103.4, 114.55 APE8-rot-in 310.75 APE67-dihe-in -64.11, -17.03 -41.21, -51.68 APE12-dist-in 10.015 APE11-dist-in 11.585 APE10-dist-in 6.327 APE9-dist-in 3.922 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 D 301 288 8 0 0 4 [[183, 456]] 1.0 4yp8 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6LXYA Q9NWZ3 163 458 460.0 EXF:501 Type1 Inactive DFGin 6.997 14.049 BLAminus -130.85, 177.02 62.25, 85.69 -105.57, 13.21 307.3, 97.03 -58.17, -30.36 in-out in 8.929 Saltbr-out 5.362 HRD-in -67.47, -54.1 77.02, 0.48 out-in-in SNCoii in-in ActLoopNT-in 2.819 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.95, 147.66 APE9-dihe-na 135.07, -175.38 APE8-dihe-in -106.14, 112.07 APE8-rot-in 312.29 APE67-dihe-in -59.29, -20.88 -52.35, -43.4 APE12-dist-in 10.191 APE11-dist-in 11.704 APE10-dist-in 6.439 APE9-dist-in 4.357 None TPO345,SEP346 TPO345,SEP346 XRAY 2.19 0.202 0.231 A 305 294 2 0 0 2 [[183, 456]] 1.0 6lxy Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6LXYB Q9NWZ3 163 459 460.0 EXF:502 Type1 None DFGin 6.973 14.137 BLAminus -129.45, 177.84 61.74, 86.54 -106.07, 12.43 306.08, 97.48 -57.61, -29.04 in-none in 9.098 Saltbr-none 999.0 HRD-in -68.65, -53.21 75.68, 1.0 none-in-in SNCnii in-in ActLoopNT-in 2.807 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.47, 149.33 APE9-dihe-na 135.3, -175.41 APE8-dihe-in -105.49, 112.4 APE8-rot-in 312.11 APE67-dihe-in -59.55, -21.17 -51.5, -42.55 APE12-dist-in 10.189 APE11-dist-in 11.686 APE10-dist-in 6.444 APE9-dist-in 4.332 None TPO345,SEP346 TPO345,SEP346 XRAY 2.19 0.202 0.231 B 305 297 0 0 0 0 [[183, 456]] 1.0 6lxy Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6LXYD Q9NWZ3 162 459 460.0 EXF:502 Type1 Inactive DFGin 7.002 14.116 BLAminus -130.62, 177.55 62.4, 85.91 -106.35, 12.8 307.19, 98.16 -58.64, -30.18 in-out in 8.943 Saltbr-out 5.354 HRD-in -67.38, -53.42 77.14, -1.48 out-in-in SNCoii in-in ActLoopNT-in 2.786 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.01, 149.8 APE9-dihe-na 134.89, -175.28 APE8-dihe-in -104.95, 111.45 APE8-rot-in 311.34 APE67-dihe-in -58.57, -21.72 -44.58, -48.25 APE12-dist-in 10.314 APE11-dist-in 11.954 APE10-dist-in 6.613 APE9-dist-in 4.254 None TPO345,SEP346 TPO345,SEP346 XRAY 2.19 0.202 0.231 D 305 293 5 0 0 5 [[183, 456]] 1.0 6lxy Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6LXYE Q9NWZ3 164 458 460.0 EXF:502 Type1 Inactive DFGin 6.954 14.159 BLAminus -130.3, 176.57 62.62, 85.73 -105.89, 13.23 306.79, 97.59 -58.45, -29.69 in-out in 8.931 Saltbr-out 5.391 HRD-in -66.96, -52.89 76.03, -0.37 out-in-in SNCoii in-in ActLoopNT-in 2.795 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.25, 150.73 APE9-dihe-na 134.77, -173.9 APE8-dihe-in -105.72, 111.9 APE8-rot-in 311.85 APE67-dihe-in -56.93, -22.86 -45.56, -48.25 APE12-dist-in 10.309 APE11-dist-in 11.905 APE10-dist-in 6.607 APE9-dist-in 4.292 None TPO345,SEP346 TPO345,SEP346 XRAY 2.19 0.202 0.231 E 305 288 7 0 0 7 [[183, 456]] 1.0 6lxy Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5 266 262 328 329 330 332 334 213 233 237 308 310 309 311 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL MAP3K12 M3K12_HUMAN 5CEQA Q12852 117 398 859.0 50F:4000 Type1 Inactive DFGin 6.285 14.143 BLBplus -139.34, 175.24 65.23, 33.46 -103.17, 163.52 57.07, 90.2 71.88, 999.0 na-na na 13.937 Saltbr-na 13.245 HRD-in -61.44, -57.14 79.98, -14.5 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -71.43, -48.01 APE9-dihe-na -72.5, -0.08 APE8-dihe-out -118.56, -4.99 APE8-rot-out 184.08 APE67-dihe-in -55.04, -30.89 -63.03, -27.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.132 None None None XRAY 1.911 0.171 0.218 A 300 269 13 0 0 13 [[118, 372]] 1.0 5ceq Homo sapiens TKL_MAP3K12_HUMAN MAP3K123 1.5e-137 462.8 1 254 254 253 254 255 257 259 152 161 165 233 235 234 236 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
TKL MAP3K7 M3K7_HUMAN 5J9LA O43318 31 496 606.0 6HF:60501 Type1 Inactive DFGout 12.964 7.575 None -126.7, 106.14 -55.49, -39.75 -39.65, 999.0 105.32, 93.88 999.0, 999.0 in-out in 9.619 Saltbr-out 4.662 HRD-in -64.53, -55.8 74.12, -2.79 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 124.52 APE8-dihe-out -91.5, 21.0 APE8-rot-in 299.75 APE67-dihe-in -63.93, -32.31 -64.12, -36.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7 None None None XRAY 2.752 0.214 0.243 A 307 253 20 0 0 14 [[36, 286]] 1.0 5j9l Homo sapiens TKL_MAP3K7_HUMAN TKL 3.7e-74 255.5 2 266 265 174 175 176 178 180 63 77 81 153 155 154 156 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
TKL RIPK1 RIPK1_HUMAN 7FCZA Q13546 10 294 671.0 3IF:301 Type3 Inactive DFGout 13.865 10.379 BBAminus -121.61, 171.92 -133.79, 66.08 -70.41, -22.3 302.99, 177.02 -85.6, 3.29 out-out out 15.002 Saltbr-out 12.85 HRD-in -69.8, -48.63 73.26, -13.72 out-out-out SNCooo out-out ActLoopNT-out 6.074 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 77.72 APE8-dihe-in -67.19, 127.43 APE8-rot-in 294.95 APE67-dihe-in -62.33, -29.47 -101.92, 1.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.476 C34A,C127A,C233A,C240A None None XRAY 2.21 0.236 0.257 A 297 248 37 0 0 18 [[17, 287]] 1.0 7fcz Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 7FCZB Q13546 7 294 671.0 3IF:301 Type3 Inactive DFGout 13.913 10.028 BBAminus -118.21, 174.22 -136.13, 64.53 -68.29, -24.74 303.09, 178.58 -83.09, -0.43 out-out out 14.189 Saltbr-out 12.575 HRD-in -73.47, -53.47 80.61, -17.48 out-out-out SNCooo out-out ActLoopNT-out 6.139 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 101.37 APE8-dihe-in -64.4, 143.44 APE8-rot-out 179.16 APE67-dihe-in -62.08, -29.26 -100.06, -1.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.634 C34A,C127A,C233A,C240A None None XRAY 2.21 0.236 0.257 B 297 263 25 0 0 17 [[17, 287]] 1.0 7fcz Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6 265 260 155 156 157 159 161 45 63 67 135 137 136 138 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL TGFBR1 TGFR1_HUMAN 2WOUA P36897 200 496 503.0 ZZF:61500 Type1 Active DFGin 6.124 13.039 BLAminus -133.49, -169.53 51.05, 62.4 -92.04, 13.34 298.31, 178.69 -62.77, -27.98 in-in in 7.586 Saltbr-in 2.752 HRD-in -65.52, -56.03 81.95, -3.97 in-in-in SNCiii in-in ActLoopNT-in 3.039 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -95.77, -22.31 APE9-dihe-na -79.77, -172.15 APE8-dihe-in -73.94, 125.36 APE8-rot-in 306.35 APE67-dihe-in -52.11, -29.79 -56.64, -45.19 APE12-dist-in 13.078 APE11-dist-in 11.935 APE10-dist-in 6.041 APE9-dist-in 3.629 None None None XRAY 2.3 0.229 0.302 A 306 297 0 0 0 0 [[205, 494]] 1.0 2wou Homo sapiens TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3 266 264 350 351 352 354 356 232 245 249 330 332 331 333 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 3FAAA P36897 171 500 503.0 55F:601 Type1 Active DFGin 5.904 13.047 BLAminus -165.74, 163.41 74.29, 54.12 -79.67, 24.05 317.06, 176.62 -56.68, -51.28 in-in in 8.001 Saltbr-in 2.936 HRD-in -45.11, -27.8 52.25, 11.68 in-in-in SNCiii in-in ActLoopNT-in 3.111 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.43, -171.19 APE9-dihe-na 80.03, 171.79 APE8-dihe-in -67.98, 121.11 APE8-rot-in 302.91 APE67-dihe-in -99.71, -73.49 -46.09, -5.99 APE12-dist-in 11.624 APE11-dist-in 11.967 APE10-dist-in 6.015 APE9-dist-in 4.061 None None None XRAY 3.35 0.228 0.271 A 342 328 2 0 0 2 [[205, 494]] 1.0 3faa Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3 266 264 350 351 352 354 356 232 245 249 330 332 331 333 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 3FAAB P36897 171 501 503.0 55F:601 Type1 Active DFGin 6.017 13.306 BLAminus -136.45, -176.24 60.04, 54.86 -81.47, 12.98 307.95, 5.19 -52.57, -45.29 in-in in 8.1 Saltbr-in 3.037 HRD-in -75.89, -39.75 60.74, 14.93 in-in-in SNCiii in-in ActLoopNT-in 3.115 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.32, 175.24 APE9-dihe-na 101.52, 166.7 APE8-dihe-in -70.87, 127.35 APE8-rot-in 315.28 APE67-dihe-in -36.34, -44.33 -43.95, -69.54 APE12-dist-in 11.94 APE11-dist-in 12.0 APE10-dist-in 6.373 APE9-dist-in 4.084 None None None XRAY 3.35 0.228 0.271 B 342 324 7 0 0 3 [[205, 494]] 1.0 3faa Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3 266 264 350 351 352 354 356 232 245 249 330 332 331 333 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 3FAAC P36897 171 500 503.0 55F:601 Type1 Inactive DFGin 6.142 13.141 BLAminus -126.27, 176.42 50.71, 78.49 -102.58, 30.06 320.3, 19.34 -66.31, -17.95 in-in in 7.99 Saltbr-in 2.662 HRD-in -67.56, -21.99 46.1, 19.37 in-in-out SNCiio in-out ActLoopNT-in 2.947 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiii APE10-dihe-na -120.66, 131.05 APE9-dihe-na 148.7, 175.0 APE8-dihe-in -102.93, 87.73 APE8-rot-in 305.5 APE67-dihe-out -28.83, -55.82 5.18, -84.04 APE12-dist-in 11.481 APE11-dist-in 12.149 APE10-dist-in 6.247 APE9-dist-in 4.208 None None None XRAY 3.35 0.228 0.271 C 342 330 0 0 0 0 [[205, 494]] 1.0 3faa Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3 266 264 350 351 352 354 356 232 245 249 330 332 331 333 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 3FAAD P36897 171 500 503.0 55F:601 Type1 Active DFGin 6.26 13.168 BLAminus -151.5, 176.63 62.94, 64.2 -90.99, 26.98 302.19, 4.38 -66.56, -19.34 in-in in 7.809 Saltbr-in 2.745 HRD-in -63.44, -55.82 78.14, 1.44 in-in-in SNCiii in-in ActLoopNT-in 2.803 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.86, 174.28 APE9-dihe-na 87.09, 173.14 APE8-dihe-in -66.87, 116.28 APE8-rot-in 325.42 APE67-dihe-in -60.47, -38.15 -48.63, -36.35 APE12-dist-in 11.714 APE11-dist-in 11.894 APE10-dist-in 6.37 APE9-dist-in 4.229 None None None XRAY 3.35 0.228 0.271 D 342 330 0 0 0 0 [[205, 494]] 1.0 3faa Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3 266 264 350 351 352 354 356 232 245 249 330 332 331 333 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 3FAAE P36897 171 500 503.0 55F:601 Type1 Active DFGin 6.355 13.366 BLAminus -131.48, -168.05 37.37, 86.28 -107.7, 26.02 296.92, 176.17 -65.92, -19.56 in-in in 7.781 Saltbr-in 3.095 HRD-in -66.77, -57.93 79.95, 12.98 in-in-in SNCiii in-in ActLoopNT-in 2.85 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.13, 169.87 APE9-dihe-na 90.72, 172.5 APE8-dihe-in -64.72, 129.04 APE8-rot-in 310.98 APE67-dihe-in -56.46, -40.64 -59.57, -42.14 APE12-dist-in 11.99 APE11-dist-in 12.056 APE10-dist-in 6.57 APE9-dist-in 3.982 None None None XRAY 3.35 0.228 0.271 E 342 330 0 0 0 0 [[205, 494]] 1.0 3faa Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3 266 264 350 351 352 354 356 232 245 249 330 332 331 333 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR2 TGFR2_HUMAN 7DV6A P37173 240 543 567.0 HJF:9000 Type1 Active DFGin 7.131 13.432 BLAminus -156.15, -164.95 57.9, 60.45 -93.44, 15.51 294.56, 110.64 -56.6, -36.89 in-in in 7.444 Saltbr-in 2.659 HRD-in -60.78, -51.79 74.77, -4.11 in-in-in SNCiii in-in ActLoopNT-in 2.86 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.14, 141.57 APE9-dihe-na 113.33, -173.4 APE8-dihe-in -82.04, 128.94 APE8-rot-in 303.35 APE67-dihe-in -55.96, -36.36 -60.86, -38.17 APE12-dist-in 11.508 APE11-dist-in 11.89 APE10-dist-in 6.046 APE9-dist-in 3.912 E431A,R433A,E485A,K488A,R493A,R495A None None XRAY 2.39 0.163 0.224 A 323 304 0 0 0 0 [[244, 540]] 1.0 7dv6 Homo sapiens TKL_TGFBR2_HUMAN TKL 2.1e-77 266.2 2 266 265 396 397 398 400 402 277 290 294 376 378 377 379 446 428 423 422 421 420 419 418 417 326 TGF-beta receptor type-2
TYR ALK ALK_HUMAN 4CCUA Q9UM73 1093 1402 1620.0 AWF:1500 Type1 Inactive DFGin 6.02 14.623 ABAminus -118.73, -9.8 -132.17, 139.04 -133.56, 37.48 295.42, 86.35 -74.53, -27.89 in-out in 8.277 Saltbr-out 4.689 HRD-in -77.94, -47.73 82.62, -10.67 out-out-out SNCooo out-out ActLoopNT-out 6.803 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.98, -27.23 APE9-dihe-in -56.62, 135.11 APE8-dihe-in -75.38, 65.75 APE8-rot-na 29.29 APE67-dihe-in -70.29, -14.23 -60.1, -29.45 APE12-dist-na 14.525 APE11-dist-na 15.17 APE10-dist-na 10.028 APE9-dist-in 7.796 None None None XRAY 2.0 0.202 0.233 A 327 293 17 0 0 6 [[1116, 1385]] 1.0 4ccu Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 4FNZA Q9UM73 1093 1402 1620.0 NZF:1501 Type1 Inactive DFGin 5.291 12.8 ABAminus -135.46, 12.02 -152.76, 153.63 -83.97, -38.55 283.31, 122.35 73.66, 999.0 in-in in 8.5 Saltbr-in 2.812 HRD-in -72.66, -49.3 78.9, -9.45 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -97.65, -24.93 APE9-dihe-in -50.61, 132.71 APE8-dihe-in -79.34, 69.48 APE8-rot-na 27.73 APE67-dihe-in -74.42, -13.21 -56.44, -36.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.83 C1097S None None XRAY 2.6 0.202 0.261 A 327 287 23 0 0 15 [[1116, 1385]] 1.0 4fnz Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 4DCEA Q9UM73 1093 1402 1620.0 0JF:1501 Type1 Inactive DFGin 5.63 13.823 None -137.27, 16.47 -161.52, 152.14 -94.73, 164.26 291.72, 122.64 -76.17, 999.0 in-in in 8.482 Saltbr-in 2.883 HRD-in -75.4, -48.78 85.77, -10.33 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -96.83, -20.84 APE9-dihe-in -55.51, 136.7 APE8-dihe-in -77.28, 70.08 APE8-rot-na 28.6 APE67-dihe-in -68.31, -8.92 -56.77, -41.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.974 C1097S None None XRAY 2.03 0.211 0.256 A 333 288 22 0 0 14 [[1116, 1385]] 1.0 4dce Homo sapiens TYR_ALK_HUMAN TYR 1.5e-90 309.0 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 4DCEB Q9UM73 1094 1402 1620.0 0JF:1501 Type1 Inactive DFGin 5.747 13.628 None -141.04, 18.73 -165.26, 150.02 -96.5, 167.37 286.77, 120.17 -70.38, 999.0 in-in in 8.563 Saltbr-in 2.99 HRD-in -72.56, -48.26 83.87, -14.3 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -96.41, -12.56 APE9-dihe-in -59.98, 136.0 APE8-dihe-in -80.48, 64.18 APE8-rot-na 31.8 APE67-dihe-in -66.1, -14.3 -52.07, -41.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.713 C1097S None None XRAY 2.03 0.211 0.256 B 333 284 25 0 0 15 [[1116, 1385]] 1.0 4dce Homo sapiens TYR_ALK_HUMAN TYR 1.5e-90 309.0 1 260 260 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR BTK BTK_HUMAN 5FBNC Q06187 395 658 659.0 5WF:701,5WE:702 Type1.5_Front,Allosteric Inactive DFGin 6.234 13.485 BLBplus -138.97, 172.93 64.41, 21.2 -64.91, 134.85 43.34, 89.93 78.28, -17.1 out-out out 15.007 Saltbr-out 15.714 HRD-in -67.81, -54.89 86.66, -24.42 out-out-out SNCooo out-out ActLoopNT-out 8.194 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out 143.31, -31.01 APE9-dihe-in -63.12, 135.49 APE8-dihe-in -76.38, 65.1 APE8-rot-na 32.35 APE67-dihe-in -72.98, -10.12 -50.46, -47.16 APE12-dist-na 999.0 APE11-dist-na 17.831 APE10-dist-na 12.608 APE9-dist-out 8.181 None None None XRAY 1.8 0.182 0.226 C 271 256 8 0 0 8 [[402, 653]] 1.0 5fbn Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 5FBND Q06187 394 658 659.0 5WF:702,5WE:703,5WE:704,5WE:705 Type1.5_Front,Allosteric,Allosteric,Allosteric Inactive DFGin 6.25 13.472 BLBplus -137.76, 172.64 65.66, 19.16 -62.24, 135.48 45.56, 88.91 74.32, -16.76 out-out out 15.056 Saltbr-out 15.752 HRD-in -65.32, -54.88 86.04, -26.38 out-out-none SNCoon out-none ActLoopNT-out 8.195 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.18 APE8-dihe-in -78.24, 64.6 APE8-rot-na 31.95 APE67-dihe-in -74.36, -8.3 -50.81, -46.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.898 None None None XRAY 1.8 0.182 0.226 D 271 255 10 0 0 10 [[402, 653]] 1.0 5fbn Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR DDR1 DDR1_HUMAN 5SAUA Q08345 604 912 913.0 1IF:61000 Type2 Inactive DFGout 12.628 9.672 BBAminus -137.39, -170.54 -153.95, 108.1 -100.48, 5.9 289.81, 101.12 83.39, -174.73 in-in in 8.355 Saltbr-in 2.869 HRD-in -71.66, -48.67 82.15, -10.52 in-out-in SNCioi out-in ActLoopNT-out 18.139 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.56, 139.94 APE9-dihe-in -129.66, 123.98 APE8-dihe-in -80.56, 70.77 APE8-rot-na 35.49 APE67-dihe-in -73.85, -9.33 -63.13, -31.85 APE12-dist-na 13.331 APE11-dist-na 10.312 APE10-dist-na 5.884 APE9-dist-in 7.555 None None None XRAY 1.8 0.201 0.231 A 321 287 16 0 0 0 [[610, 907]] 1.0 5sau Homo sapiens TYR_DDR1_HUMAN TYR 1.4e-92 315.7 1 260 260 783 784 785 787 789 655 672 676 763 765 764 766 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR EPHA2 EPHA2_HUMAN 8BOCA P29317 605 888 976.0 QUF:1001 Type2 Inactive DFGout 13.583 10.813 BBAminus -139.62, -179.28 -151.24, 106.28 -78.98, -6.2 302.64, 171.21 84.05, 5.79 in-in in 8.869 Saltbr-in 3.501 HRD-in -70.68, -54.7 83.35, -19.69 in-out-in SNCioi out-in ActLoopNT-out 12.248 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.53, 160.37 APE9-dihe-in -116.01, 148.45 APE8-dihe-in -79.02, 97.78 APE8-rot-na 34.23 APE67-dihe-in -77.84, -8.8 -56.96, -40.4 APE12-dist-na 12.844 APE11-dist-na 9.325 APE10-dist-na 7.892 APE9-dist-in 5.837 None None None XRAY 1.9 0.248 0.286 A 306 271 13 0 0 0 [[613, 873]] 1.0 8boc Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2 261 260 756 757 758 760 762 646 663 667 736 738 737 739 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHB4 EPHB4_HUMAN 2X9FA P54760 608 888 987.0 X9F:1889 Type1 Inactive DFGin 6.208 14.33 BLBminus -134.1, -172.08 65.01, 71.96 -106.66, 162.22 301.36, 107.12 163.16, 158.85 in-in in 7.543 Saltbr-in 2.703 HRD-in -73.92, -48.13 77.71, -16.54 in-out-in SNCioi out-in ActLoopNT-out 9.79 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.56, 149.08 APE9-dihe-in -55.67, 129.32 APE8-dihe-in -83.14, 89.74 APE8-rot-na 29.6 APE67-dihe-in -62.34, -22.56 -52.45, -48.78 APE12-dist-na 8.363 APE11-dist-na 11.417 APE10-dist-na 15.416 APE9-dist-in 6.34 Y774E None None XRAY 1.75 0.159 0.194 A 302 265 16 0 0 13 [[615, 876]] 1.0 2x9f Homo sapiens TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2 261 260 757 758 759 761 763 647 664 668 737 739 738 740 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR FGFR1 FGFR1_HUMAN 9UHIA P11362 458 764 822.0 A1EPF:60801 Type1 Inactive DFGin 5.058 13.436 BLAplus -111.91, 163.26 62.65, 26.85 -80.22, -19.74 58.59, 88.0 -94.12, 4.52 in-in in 8.251 Saltbr-in 2.888 HRD-in -74.14, -50.3 78.02, -11.1 in-out-out SNCioo out-out ActLoopNT-out 7.511 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -88.77, 149.44 APE9-dihe-in -108.01, 98.39 APE8-dihe-out -63.46, -15.87 APE8-rot-na 3.35 APE67-dihe-in -71.69, -10.38 -55.45, -26.93 APE12-dist-na 17.216 APE11-dist-na 19.672 APE10-dist-na 16.685 APE9-dist-out 11.083 None None None XRAY 1.76 0.163 0.197 A 310 307 0 0 0 0 [[478, 756]] 1.0 9uhi Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 9UHIB P11362 458 763 822.0 A1EPF:60801 Type1 Inactive DFGin 5.213 12.738 BLAplus -108.15, 164.77 66.41, 24.28 -84.34, -17.16 58.96, 83.83 -89.87, -8.4 in-in in 7.768 Saltbr-in 3.449 HRD-in -77.39, -52.67 76.89, -15.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -74.45, 132.66 APE9-dihe-in -102.74, 93.19 APE8-dihe-out -60.68, -21.29 APE8-rot-na 332.28 APE67-dihe-in -72.11, -2.38 -56.87, -27.58 APE12-dist-na 17.352 APE11-dist-na 20.682 APE10-dist-na 16.965 APE9-dist-out 11.364 None None None XRAY 1.76 0.163 0.197 B 310 286 20 0 0 7 [[478, 756]] 1.0 9uhi Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 3C4FA P11362 464 765 822.0 C4F:1 Type1.5_Back Inactive DFGin 5.114 13.318 BLAplus -110.44, 159.78 58.59, 34.58 -81.02, -11.31 51.22, 81.2 -119.48, 23.64 in-out in 7.866 Saltbr-out 4.632 HRD-in -67.82, -57.48 84.79, -17.47 out-out-out SNCooo out-out ActLoopNT-out 9.069 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -97.31, 173.6 APE9-dihe-in -111.71, 110.92 APE8-dihe-out -49.57, -28.9 APE8-rot-na 335.93 APE67-dihe-in -76.49, -6.67 -57.78, -16.15 APE12-dist-na 19.292 APE11-dist-na 21.121 APE10-dist-na 19.395 APE9-dist-out 11.757 C488A None None XRAY 2.07 0.213 0.264 A 302 290 12 0 0 0 [[478, 756]] 1.0 3c4f Homo sapiens TYR_FGFR1_HUMAN TYR 1.3e-104 355.0 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 3C4FB P11362 464 765 822.0 C4F:2 Type1.5_Back Inactive DFGin 5.186 13.096 BLAplus -113.87, 161.2 54.21, 44.76 -88.95, -14.38 49.14, 89.01 -114.94, 24.21 in-in in 7.831 Saltbr-in 3.248 HRD-in -69.91, -54.09 86.4, -33.67 in-out-out SNCioo out-out ActLoopNT-out 8.934 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.54, 164.12 APE9-dihe-in -103.97, 111.75 APE8-dihe-out -49.46, -30.24 APE8-rot-na 330.07 APE67-dihe-in -74.8, -7.14 -56.82, -17.81 APE12-dist-na 19.37 APE11-dist-na 21.296 APE10-dist-na 19.671 APE9-dist-out 11.643 C488A None None XRAY 2.07 0.213 0.264 B 302 290 12 0 0 0 [[478, 756]] 1.0 3c4f Homo sapiens TYR_FGFR1_HUMAN TYR 1.3e-104 355.0 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 5EW8A P11362 464 765 822.0 5SF:803 Type1.5_Back Inactive DFGin 4.948 13.265 BLAplus -106.94, 161.6 53.73, 34.99 -75.93, -13.84 56.0, 83.89 -112.21, 7.75 in-in in 7.954 Saltbr-in 2.801 HRD-in -68.23, -51.53 79.48, -14.26 in-out-out SNCioo out-out ActLoopNT-out 9.067 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.87, 162.8 APE9-dihe-in -100.01, 112.78 APE8-dihe-out -57.6, -21.18 APE8-rot-na 333.77 APE67-dihe-in -70.4, -6.07 -56.33, -25.26 APE12-dist-na 19.37 APE11-dist-na 20.743 APE10-dist-na 19.216 APE9-dist-out 11.882 None None None XRAY 1.63 0.186 0.206 A 309 291 11 0 0 0 [[478, 756]] 1.0 5ew8 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 5EW8B P11362 461 765 822.0 5SF:802 Type1.5_Back Inactive DFGin 5.002 13.124 BLAplus -109.75, 160.16 55.05, 34.73 -78.35, -12.87 54.65, 85.31 -106.64, 12.94 in-in in 7.88 Saltbr-in 2.807 HRD-in -67.52, -52.32 78.89, -12.97 in-out-out SNCioo out-out ActLoopNT-out 8.38 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.81, 162.42 APE9-dihe-in -99.2, 111.94 APE8-dihe-out -57.42, -21.49 APE8-rot-na 334.53 APE67-dihe-in -69.99, -6.88 -56.65, -24.13 APE12-dist-na 19.902 APE11-dist-na 21.169 APE10-dist-na 19.654 APE9-dist-out 11.767 None None None XRAY 1.63 0.186 0.206 B 309 290 15 0 0 2 [[478, 756]] 1.0 5ew8 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 7WCLA P11362 459 764 822.0 8ZF:60801 Type1.5_Back Inactive DFGin 5.032 13.511 BLAplus -110.65, 158.43 54.71, 42.71 -89.1, -11.93 53.54, 87.56 -114.63, 26.86 in-in in 8.234 Saltbr-in 2.943 HRD-in -65.51, -45.04 70.13, -0.28 in-out-out SNCioo out-out ActLoopNT-out 7.98 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -98.05, 142.67 APE9-dihe-in -99.82, 98.85 APE8-dihe-out -66.04, -10.56 APE8-rot-na 23.45 APE67-dihe-in -75.78, -2.11 -60.96, -29.19 APE12-dist-na 16.725 APE11-dist-na 19.067 APE10-dist-na 16.226 APE9-dist-out 11.223 C584S None None XRAY 2.495 0.195 0.23 A 310 306 0 0 0 0 [[478, 756]] 1.0 7wcl Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 7WCLB P11362 458 763 822.0 8ZF:60801 Type1.5_Back Inactive DFGin 5.686 13.297 BLAplus -116.0, 164.36 53.53, 38.11 -89.51, -19.74 50.41, 88.95 -102.65, 11.92 in-in in 8.381 Saltbr-in 2.804 HRD-in -77.55, -44.61 69.5, -1.67 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -124.03, 166.88 APE9-dihe-in -112.63, 116.79 APE8-dihe-out -58.21, -18.36 APE8-rot-na 340.54 APE67-dihe-in -81.23, 2.92 -65.55, -20.31 APE12-dist-na 18.6 APE11-dist-na 21.605 APE10-dist-na 19.498 APE9-dist-out 11.402 C584S None None XRAY 2.495 0.195 0.23 B 310 285 21 0 0 8 [[478, 756]] 1.0 7wcl Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1 260 260 640 641 642 644 646 514 531 535 620 622 621 623 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR3 FGFR3_HUMAN 8UDTA P22607 457 756 806.0 MLT:61001,MLT:61002,WGF:61003 Allosteric,Allosteric,Type1.5_Front Inactive DFGin 5.441 13.493 BLAplus -114.8, 158.79 55.69, 43.2 -82.19, -34.37 42.84, 89.08 -83.27, -4.41 in-out in 8.383 Saltbr-out 5.287 HRD-in -68.34, -46.54 75.89, -9.4 out-out-out SNCooo out-out ActLoopNT-out 7.921 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 112.29 APE8-dihe-out -63.06, -32.23 APE8-rot-na 340.92 APE67-dihe-in -68.35, -26.42 -62.13, -28.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.198 P572S,P573G None None XRAY 2.829 0.263 0.274 A 297 284 4 0 0 4 [[472, 750]] 1.0 8udt Homo sapiens TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 8UDTB P22607 457 754 806.0 WGF:62001 Type1.5_Front Inactive DFGin 5.258 13.71 BLAplus -108.64, 157.87 56.15, 40.62 -79.39, -35.54 45.72, 88.06 -80.67, 0.1 in-out in 8.445 Saltbr-out 5.398 HRD-in -67.98, -43.8 74.91, -8.8 out-out-out SNCooo out-out ActLoopNT-out 7.867 ActLoopCT-out TYR APEdihe_nooai APEdist_aaao APE10-dihe-none 999.0, -64.67 APE9-dihe-out -68.82, -39.67 APE8-dihe-out -56.45, -17.85 APE8-rot-na 337.42 APE67-dihe-in -61.76, -27.35 -59.02, -40.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.666 APE9-dist-out 10.854 P572S,P573G None None XRAY 2.829 0.263 0.274 B 297 283 3 0 0 3 [[472, 750]] 1.0 8udt Homo sapiens TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 8UDTC P22607 457 756 806.0 WGF:62001 Type1.5_Front Inactive DFGin 5.258 13.824 BLAplus -109.74, 157.08 55.91, 40.67 -78.94, -35.79 45.97, 87.77 -81.04, -4.46 in-out in 8.545 Saltbr-out 4.103 HRD-in -68.09, -46.3 75.11, -4.3 out-out-out SNCooo out-out ActLoopNT-out 7.87 ActLoopCT-out TYR APEdihe_nooai APEdist_aaao APE10-dihe-none 999.0, -150.08 APE9-dihe-out -67.3, -42.56 APE8-dihe-out -46.98, -31.66 APE8-rot-na 333.46 APE67-dihe-in -60.08, -29.46 -58.03, -43.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.405 APE9-dist-out 11.049 P572S,P573G None None XRAY 2.829 0.263 0.274 C 297 284 4 0 0 4 [[472, 750]] 1.0 8udt Homo sapiens TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1 260 260 634 635 636 638 640 508 525 529 614 616 615 617 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR4 FGFR4_HUMAN 7WCXA P22455 453 752 802.0 90F:801 Type1 Inactive DFGin 5.263 13.141 BLAplus -114.81, 160.0 54.39, 48.08 -89.68, -16.38 44.55, 83.39 -109.65, 26.27 in-in in 7.792 Saltbr-in 2.511 HRD-in -76.2, -43.73 72.01, -8.39 in-out-out SNCioo out-out ActLoopNT-out 8.644 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -80.24, 137.24 APE9-dihe-in -109.54, 93.42 APE8-dihe-out -57.65, -19.77 APE8-rot-na 335.57 APE67-dihe-in -71.93, -5.42 -64.19, -25.82 APE12-dist-na 19.074 APE11-dist-na 20.85 APE10-dist-na 16.822 APE9-dist-out 11.904 C477A,R664E None None XRAY 2.175 0.173 0.221 A 309 300 0 0 0 0 [[467, 745]] 1.0 7wcx Homo sapiens TYR_FGFR4_HUMAN TYR 7e-101 342.8 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 7WCWA P22455 453 752 802.0 90F:801 Type1 Inactive DFGin 5.839 13.063 BLAplus -123.48, 161.59 54.95, 50.1 -96.76, -24.53 39.59, 83.16 -101.63, 31.89 in-in in 7.582 Saltbr-in 3.4 HRD-in -77.43, -45.16 72.65, -7.54 in-out-out SNCioo out-out ActLoopNT-out 8.633 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -81.49, 135.61 APE9-dihe-in -107.87, 94.77 APE8-dihe-out -59.45, -18.22 APE8-rot-na 336.81 APE67-dihe-in -74.15, -1.22 -67.3, -23.03 APE12-dist-na 19.435 APE11-dist-na 20.996 APE10-dist-na 16.929 APE9-dist-out 11.84 C477A,R664E None None XRAY 2.317 0.179 0.221 A 309 300 0 0 0 0 [[467, 745]] 1.0 7wcw Homo sapiens TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 6JPJA P22455 454 752 802.0 FGF:800 Type1 Inactive DFGin 5.301 12.658 BLAplus -117.71, 161.57 53.08, 42.72 -89.02, -4.4 50.47, 87.12 -117.52, 24.43 in-in in 7.247 Saltbr-in 2.318 HRD-out -71.89, 98.16 -78.45, 15.53 in-out-out SNCioo out-out ActLoopNT-out 8.002 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -85.03, 139.81 APE9-dihe-in -112.83, 87.62 APE8-dihe-out -50.76, -19.28 APE8-rot-na 332.54 APE67-dihe-in -80.03, 5.83 -68.35, -18.64 APE12-dist-na 19.294 APE11-dist-na 21.068 APE10-dist-na 17.129 APE9-dist-out 12.054 C477A,R664E None None XRAY 2.638 0.198 0.243 A 311 299 0 0 0 0 [[467, 745]] 1.0 6jpj Homo sapiens TYR_FGFR4_HUMAN TYR 1.3e-100 341.9 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 7VJLA P22455 454 753 802.0 7IF:801 Type1 Inactive DFGin 5.301 12.42 BLAplus -114.78, 170.3 57.71, 40.42 -94.32, 21.48 55.77, 90.38 -107.29, 999.0 in-in in 7.485 Saltbr-in 2.904 HRD-out -79.19, -58.83 -98.34, 2.36 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 2.26 APE8-rot-na 31.94 APE67-dihe-in -59.38, -20.97 -56.11, -39.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.212 0.273 A 301 263 37 0 0 19 [[467, 745]] 1.0 7vjl Homo sapiens TYR_FGFR4_HUMAN TYR 1.1e-100 342.2 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 7VJLB P22455 453 753 802.0 7IF:801 Type1 Inactive DFGin 5.405 13.204 BLAplus -123.58, 175.88 60.77, 35.86 -95.6, 5.83 48.51, 81.65 -122.94, 999.0 in-in in 7.876 Saltbr-in 2.665 HRD-out -72.76, -57.66 -103.85, -18.8 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 6.57 APE8-rot-na 30.25 APE67-dihe-in -55.58, -34.43 -70.09, -36.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.212 0.273 B 301 266 35 0 0 19 [[467, 745]] 1.0 7vjl Homo sapiens TYR_FGFR4_HUMAN TYR 1.1e-100 342.2 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 6YI8A P22455 453 753 802.0 FGF:801 Type1 Inactive DFGin 5.052 12.585 BLAplus -114.37, 162.1 61.01, 37.7 -86.22, -22.44 57.75, 86.82 -88.83, -1.63 in-in in 7.21 Saltbr-in 2.807 HRD-in -68.35, -54.97 79.66, -18.38 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 137.99 APE9-dihe-in -91.08, 144.79 APE8-dihe-in -80.88, 56.75 APE8-rot-na 32.63 APE67-dihe-in -69.74, -13.54 -50.67, -37.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 19.129 APE9-dist-out 9.562 None None None XRAY 2.13 0.198 0.231 A 307 277 24 0 0 15 [[467, 745]] 1.0 6yi8 Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 6YI8B P22455 451 752 802.0 FGF:801 Type1 Inactive DFGin 5.551 13.074 BLAplus -114.83, 168.14 49.73, 54.77 -99.35, -32.03 46.0, 89.99 -71.98, 999.0 in-in in 7.399 Saltbr-in 2.814 HRD-in -67.69, -51.4 79.31, -36.01 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.49 APE8-dihe-in -88.73, 63.1 APE8-rot-na 25.93 APE67-dihe-in -70.74, -12.22 -53.82, -35.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.081 None None None XRAY 2.13 0.198 0.231 B 307 270 32 0 0 18 [[467, 745]] 1.0 6yi8 Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 7WCTA P22455 453 752 802.0 90F:801 Type1 Inactive DFGin 5.499 13.008 BLAplus -115.75, 158.15 54.59, 44.67 -82.33, -22.35 42.51, 87.35 -106.03, 33.12 in-in in 7.476 Saltbr-in 2.881 HRD-in -76.31, -44.07 70.33, -3.05 in-out-out SNCioo out-out ActLoopNT-out 8.497 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -84.18, 139.68 APE9-dihe-in -111.32, 93.14 APE8-dihe-out -55.09, -20.87 APE8-rot-na 333.3 APE67-dihe-in -74.74, -3.5 -65.15, -23.14 APE12-dist-na 19.463 APE11-dist-na 21.045 APE10-dist-na 17.074 APE9-dist-out 11.772 R664E None None XRAY 2.106 0.184 0.217 A 311 300 0 0 0 0 [[467, 745]] 1.0 7wct Homo sapiens TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 5XFJA P22455 453 750 802.0 6LF:801 Type1 Inactive DFGin 5.021 13.251 None -115.6, 133.16 70.83, 138.96 -157.69, 175.22 19.16, 82.91 -161.9, 174.05 in-out in 8.31 Saltbr-out 4.274 HRD-out -142.96, 112.57 -85.34, -51.29 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -47.84 APE8-dihe-in -93.04, 75.41 APE8-rot-na 34.31 APE67-dihe-in -59.81, -17.88 -81.83, -32.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.229 V550M None None XRAY 3.25 0.284 0.336 A 311 266 32 0 0 17 [[467, 745]] 1.0 5xfj Homo sapiens TYR_FGFR4_HUMAN TYR 4.5e-101 343.4 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 5XFFA P22455 453 750 802.0 6LF:801 Type1 Inactive DFGin 7.251 13.8 None -91.81, 157.14 71.12, 141.83 -151.53, 140.75 303.34, 100.5 -174.03, 158.26 in-in in 7.907 Saltbr-in 3.562 HRD-out -144.83, 101.6 -75.14, -41.6 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -18.13 APE8-dihe-in -83.47, 67.75 APE8-rot-na 31.32 APE67-dihe-in -75.73, 1.3 -73.66, -27.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.541 V550L None None XRAY 2.7 0.27 0.32 A 311 269 29 0 0 17 [[467, 745]] 1.0 5xff Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 5JKGA P22455 453 750 802.0 6LF:801 Type1 Inactive DFGin 4.645 13.415 None -80.35, 138.57 42.13, 154.03 -151.26, -44.79 29.5, 89.83 59.57, 154.84 in-in in 7.788 Saltbr-in 2.748 HRD-out -157.35, 80.6 -45.38, -51.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -51.98 APE8-dihe-in -77.75, 74.49 APE8-rot-na 28.85 APE67-dihe-in -78.7, 0.61 -72.33, -28.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.405 None None None XRAY 2.352 0.237 0.277 A 311 266 32 0 0 17 [[467, 745]] 1.0 5jkg Homo sapiens TYR_FGFR4_HUMAN TYR 8.4e-101 342.6 1 261 261 629 630 631 633 635 503 520 524 609 611 610 612 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FLT3 FLT3_HUMAN 6JQRA P36888 571 951 993.0 C6F:1001 Type1 Inactive DFGout 15.394 10.885 None -119.73, 157.71 -104.23, 115.68 77.2, 999.0 255.94, 91.42 999.0, 999.0 in-in in 8.326 Saltbr-in 2.804 HRD-out -98.26, 117.82 -85.48, 11.47 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -131.05, 100.76 APE9-dihe-in -103.87, 123.04 APE8-dihe-in -78.74, 70.62 APE8-rot-na 34.5 APE67-dihe-in -69.1, -11.06 -54.04, -46.43 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.223 None None None XRAY 2.2 0.181 0.213 A 330 301 29 0 0 6 [[610, 945]] 1.0 6jqr Homo sapiens TYR_FLT3_HUMAN TYR 8.5e-103 349.1 1 259 259 828 829 830 832 834 644 661 665 808 810 809 811 870 858 853 852 851 850 849 848 847 692 Receptor-type tyrosine-protein kinase FLT3
TYR HCK HCK_HUMAN 3VS4A P08631 81 526 526.0 VSF:60603 Type1.5_Back Inactive DFGin 5.296 12.617 BLBplus -129.05, 156.5 78.18, 7.28 -55.31, 122.08 48.34, 94.72 91.65, -36.18 out-out out 13.53 Saltbr-out 14.391 HRD-in -89.51, -57.9 84.08, -11.13 out-out-out SNCooo out-out ActLoopNT-out 6.875 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 47.3 APE8-dihe-in -93.7, 67.91 APE8-rot-na 28.82 APE67-dihe-in -68.45, -16.47 -64.44, -22.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.697 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.747 0.265 0.265 A 454 429 11 0 0 11 [[262, 513]] 1.0 3vs4 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1 260 260 398 399 400 402 404 290 305 309 378 380 379 381 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 3VS4B P08631 81 526 526.0 VSF:60603 Type1.5_Back Inactive DFGin 5.285 12.665 BLBplus -120.89, 167.83 61.49, 15.86 -62.02, 121.53 47.24, 95.4 75.03, 10.7 out-out out 13.766 Saltbr-out 15.042 HRD-in -94.45, -46.27 74.87, -7.2 out-out-out SNCooo out-out ActLoopNT-out 7.135 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 48.23 APE8-dihe-in -84.31, 74.96 APE8-rot-na 34.0 APE67-dihe-in -71.24, -2.76 -88.69, -13.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.595 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.747 0.265 0.265 B 454 434 12 0 0 12 [[262, 513]] 1.0 3vs4 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1 260 260 398 399 400 402 404 290 305 309 378 380 379 381 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR JAK2-1 JAK2_HUMAN 8B9EA O60674 536 809 1132.0 Q7F:1003 Type1 Pseudo DFGin 5.769 13.226 None -72.27, 175.04 -67.31, 162.54 -76.41, -26.42 340.6, 33.67 78.05, -163.23 out-na out 11.726 Saltbr-na 999.0 HRD-in -83.9, -60.17 88.41, -6.41 na-out-out SNCaoo out-out ActLoopNT-out 8.95 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.18, -39.02 APE9-dihe-out -59.74, -28.13 APE8-dihe-out -86.36, 6.28 APE8-rot-na 284.57 APE67-dihe-out -105.41, 26.85 -68.63, 134.78 APE12-dist-na 9.613 APE11-dist-na 11.316 APE10-dist-na 15.854 APE9-dist-out 12.106 W777A,F794H None None XRAY 1.5 0.17 0.194 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8b9e Homo sapiens TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B9HA O60674 536 809 1132.0 Q7F:901 Type1 Pseudo DFGin 6.01 13.307 None -84.93, -177.89 -74.12, 157.3 -67.76, -31.57 343.4, 32.07 81.26, -168.8 out-na out 12.097 Saltbr-na 999.0 HRD-in -82.25, -60.3 91.76, -5.32 na-out-out SNCaoo out-out ActLoopNT-out 9.143 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.85, -39.85 APE9-dihe-out -62.27, -26.85 APE8-dihe-out -86.04, 1.76 APE8-rot-na 292.25 APE67-dihe-out -100.68, 23.58 -62.84, 136.16 APE12-dist-na 9.712 APE11-dist-na 11.434 APE10-dist-na 15.933 APE9-dist-out 12.428 W659A,W777A,F794H None None XRAY 1.5 0.182 0.208 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 8b9h Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR KDR VGFR2_HUMAN 3VO3A P35968 812 1168 1356.0 0KF:2001 Type2 Inactive DFGout 16.448 8.215 None -125.16, 179.81 -141.05, 99.79 -70.03, -34.74 215.55, 55.41 59.77, -120.61 in-in in 7.357 Saltbr-in 2.898 HRD-in -84.45, -53.71 76.95, -3.4 in-out-in SNCioi out-in ActLoopNT-out 16.477 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.91, 109.54 APE9-dihe-in -120.7, 147.5 APE8-dihe-in -78.09, 65.8 APE8-rot-na 32.33 APE67-dihe-in -67.73, -12.3 -53.4, -39.21 APE12-dist-na 17.03 APE11-dist-na 14.067 APE10-dist-na 11.393 APE9-dist-in 7.997 None None None XRAY 1.52 0.162 0.182 A 318 303 4 0 0 0 [[834, 1162]] 1.0 3vo3 Homo sapiens TYR_KDR_HUMAN TYR 4.2e-100 340.3 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
TYR KDR VGFR2_HUMAN 1YWNA P35968 820 1171 1356.0 LIF:60301 Type1 Inactive None 999.0 999.0 None -128.91, 171.96 -143.62, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 7.21 Saltbr-in 2.725 HRD-in -77.88, -50.07 82.87, -17.6 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -141.39, 161.44 APE9-dihe-in -104.18, 100.32 APE8-dihe-out -56.09, -24.71 APE8-rot-na 336.02 APE67-dihe-in -70.59, -14.0 -51.58, -32.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.239 E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 1.71 0.206 0.23 A 316 281 21 0 0 6 [[834, 1162]] 1.0 1ywn Homo sapiens TYR_KDR_HUMAN TYR 4.1e-100 340.3 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
TYR LCK LCK_HUMAN 2ZM1A P06239 231 501 509.0 KSF:513 Type1 Active DFGin 6.499 14.193 BLAminus -132.48, -160.42 31.13, 88.01 -99.25, 22.14 293.45, 97.67 -69.47, -32.89 in-in in 8.512 Saltbr-in 2.933 HRD-in -100.89, -51.07 73.44, -7.06 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.43, 148.33 APE9-dihe-in -138.82, 152.04 APE8-dihe-in -57.54, 117.05 APE8-rot-na 333.13 APE67-dihe-in -71.51, -24.6 -61.57, -39.74 APE12-dist-na 15.101 APE11-dist-na 10.35 APE10-dist-na 13.014 APE9-dist-in 6.822 None PTR394 PTR394 XRAY 2.1 0.172 0.232 A 285 271 0 0 0 0 [[245, 496]] 1.0 2zm1 Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.1 1 260 260 381 382 383 385 387 273 288 292 361 363 362 364 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
TYR MERTK MERTK_HUMAN 9BHIA Q12866 578 864 999.0 A1APF:60901 Type1.5_Front Inactive DFGin 6.992 12.805 BLAminus -138.66, -158.87 44.96, 74.5 -90.39, 18.73 305.52, 137.7 -55.48, -30.3 out-out out 13.615 Saltbr-out 13.031 HRD-in -81.75, -51.8 68.35, 6.62 out-in-out SNCoio in-out ActLoopNT-in 2.82 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.15, 11.33 APE9-dihe-in -72.53, 150.77 APE8-dihe-in -64.75, 117.67 APE8-rot-na 25.92 APE67-dihe-in -73.91, -0.64 -53.67, -34.29 APE12-dist-na 7.154 APE11-dist-na 12.056 APE10-dist-na 11.657 APE9-dist-in 6.71 None None None XRAY 2.07 0.211 0.23 A 323 278 9 0 0 2 [[587, 856]] 1.0 9bhi Homo sapiens TYR_MERTK_HUMAN TYR 1.6e-92 315.5 2 261 260 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AB1A Q12866 571 862 999.0 C6F:60901 Type1 Inactive DFGin 5.872 13.527 None -150.27, 178.21 48.78, 48.66 -107.87, 999.0 41.9, 85.18 999.0, 999.0 out-out out 12.844 Saltbr-out 9.566 HRD-in -84.92, -52.07 85.67, -41.55 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 62.29 APE8-rot-na 36.31 APE67-dihe-in -65.53, -14.5 -57.08, -42.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.93 0.237 0.298 A 298 267 25 0 0 20 [[587, 856]] 1.0 7ab1 Homo sapiens TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2 260 259 740 741 742 744 746 619 637 641 720 722 721 723 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MET MET_HUMAN 3ZCLA P08581 1052 1345 1390.0 5TF:1 Type1 Inactive DFGin 5.341 14.033 BLBplus -130.37, -159.34 48.43, 53.41 -147.61, 165.56 74.15, 92.01 59.61, -131.84 out-out out 14.636 Saltbr-out 12.785 HRD-in -76.45, -51.81 82.5, -13.86 out-out-in SNCooi out-in ActLoopNT-out 10.735 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.5, 109.91 APE9-dihe-in -127.18, 152.9 APE8-dihe-in -78.54, 68.73 APE8-rot-na 30.54 APE67-dihe-in -82.79, -0.65 -60.11, -28.04 APE12-dist-na 22.937 APE11-dist-na 18.131 APE10-dist-na 17.771 APE9-dist-in 7.357 None None None XRAY 1.4 0.194 0.211 A 306 291 3 0 0 0 [[1078, 1339]] 1.0 3zcl Homo sapiens TYR_MET_HUMAN TYR 6.7e-92 313.6 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 4MXCA P08581 1052 1346 1390.0 DWF:1401 Type2 Inactive DFGout 14.41 10.337 BBAminus -151.35, -174.18 -156.99, 122.43 -67.95, -16.78 287.52, 70.23 58.23, -116.98 in-in in 8.929 Saltbr-in 3.515 HRD-in -73.25, -51.06 80.68, -17.87 in-out-in SNCioi out-in ActLoopNT-out 15.287 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -88.68, 108.68 APE9-dihe-in -118.71, 133.81 APE8-dihe-in -79.71, 72.93 APE8-rot-na 28.81 APE67-dihe-in -75.71, -5.79 -60.94, -31.89 APE12-dist-na 999.0 APE11-dist-na 13.628 APE10-dist-na 10.273 APE9-dist-in 7.344 None None None XRAY 1.632 0.18 0.207 A 319 290 5 0 0 5 [[1078, 1339]] 1.0 4mxc Homo sapiens TYR_MET_HUMAN TYR 7.7e-92 313.7 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5H3QA P04629 484 796 796.0 7HF:1001 Type1 Inactive DFGout 12.708 6.583 BBAminus 172.54, 156.19 -157.42, 160.24 -99.39, 17.97 295.12, 97.4 79.34, 29.52 in-out in 9.447 Saltbr-out 5.851 HRD-in -81.9, -52.58 77.47, -12.71 out-out-in SNCooi out-in ActLoopNT-out 15.801 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -128.94, 112.39 APE9-dihe-in -107.73, 133.13 APE8-dihe-in -79.15, 63.42 APE8-rot-na 34.45 APE67-dihe-in -63.33, -18.08 -61.61, -34.65 APE12-dist-na 13.748 APE11-dist-na 15.2 APE10-dist-na 10.681 APE9-dist-in 7.568 None None None XRAY 2.1 0.19 0.215 A 324 303 10 0 0 0 [[510, 783]] 1.0 5h3q Homo sapiens TYR_NTRK1_HUMAN TYR 2.4e-100 341.1 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5KMJA P04629 486 795 796.0 6UF:901 Type3 Inactive DFGout 12.074 7.602 None 156.98, 152.76 -155.56, 161.93 -106.33, 28.22 308.11, 127.92 67.17, 26.59 in-in in 9.714 Saltbr-in 2.772 HRD-in -79.87, -55.53 78.72, -12.42 in-out-in SNCioi out-in ActLoopNT-out 16.107 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.86, 120.05 APE9-dihe-in -107.69, 130.38 APE8-dihe-in -83.48, 63.94 APE8-rot-na 32.0 APE67-dihe-in -63.64, -21.11 -52.37, -37.83 APE12-dist-na 15.016 APE11-dist-na 15.494 APE10-dist-na 11.096 APE9-dist-in 7.6 None None None XRAY 2.04 0.196 0.226 A 329 300 6 0 0 0 [[510, 783]] 1.0 5kmj Homo sapiens TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2 260 259 667 668 669 671 673 544 560 564 647 649 648 650 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR PTK2 FAK1_HUMAN 4EBWA Q05397 411 686 1052.0 0PF:700 Type1 Inactive DFGinter 10.52 8.023 None -156.77, 167.19 -119.55, 38.35 -154.8, 160.1 57.14, 97.67 -105.09, 155.15 in-in in 7.232 Saltbr-in 3.021 HRD-out -85.85, 108.83 -92.42, -13.42 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 105.2 APE9-dihe-in -103.42, 143.85 APE8-dihe-in -74.96, 72.04 APE8-rot-na 29.05 APE67-dihe-in -70.29, -24.24 -52.29, -39.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 17.857 APE9-dist-out 9.391 None None None XRAY 2.65 0.186 0.273 A 304 259 17 0 0 15 [[422, 678]] 1.0 4ebw Homo sapiens TYR_PTK2_HUMAN TYR 4.7e-93 317.2 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR SYK KSYK_HUMAN 5LMBA P43405 364 634 635.0 6ZF:701 Type1 Active DFGin 6.448 14.283 BLAminus -131.02, -173.87 62.28, 69.39 -93.16, 19.0 290.08, 82.25 -59.68, -28.46 in-in in 7.696 Saltbr-in 2.454 HRD-in -78.06, -53.9 76.38, 4.89 in-in-in SNCiii in-in ActLoopNT-in 2.963 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.66, 104.96 APE9-dihe-in -108.73, 152.4 APE8-dihe-in -79.7, 70.25 APE8-rot-na 31.84 APE67-dihe-in -69.34, -16.13 -51.43, -34.69 APE12-dist-na 13.073 APE11-dist-na 10.546 APE10-dist-na 11.448 APE9-dist-in 6.959 None PTR525 PTR525 XRAY 1.95 0.178 0.228 A 277 265 6 0 0 0 [[370, 628]] 1.0 5lmb Homo sapiens TYR_SYK_HUMAN TYR 4.6e-90 307.4 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 5LMBB P43405 364 630 635.0 6ZF:701 Type1 None DFGin 6.542 14.207 BLAminus -133.05, -174.7 62.98, 72.21 -97.02, 21.38 290.54, 88.36 -62.52, -32.46 in-in in 7.737 Saltbr-in 2.556 HRD-in -77.26, -52.74 74.6, 8.57 in-in-none SNCiin in-none ActLoopNT-in 2.872 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.43 APE8-dihe-in -80.7, 73.18 APE8-rot-na 30.16 APE67-dihe-in -64.42, -18.25 -49.18, -37.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.948 None PTR525 PTR525 XRAY 1.95 0.178 0.228 B 277 262 5 0 0 5 [[370, 628]] 1.0 5lmb Homo sapiens TYR_SYK_HUMAN TYR 4.6e-90 307.4 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4YJOA P43405 363 632 635.0 4DF:701 Type1 Active DFGin 7.151 15.404 BLAminus -136.57, 178.57 59.58, 80.7 -95.16, 22.65 286.36, 75.19 -55.96, -31.16 in-in in 8.32 Saltbr-in 3.044 HRD-in -80.48, -52.4 72.29, 6.84 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -56.5, 127.44 APE9-dihe-in -144.08, 83.31 APE8-dihe-in -75.74, 70.97 APE8-rot-na 33.07 APE67-dihe-in -63.43, -16.56 -52.99, -37.5 APE12-dist-na 999.0 APE11-dist-na 10.63 APE10-dist-na 7.9 APE9-dist-in 7.507 None None None XRAY 1.6 0.186 0.23 A 281 267 3 0 0 3 [[370, 628]] 1.0 4yjo Homo sapiens TYR_SYK_HUMAN TYR 4.8e-90 307.3 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 5TT7A P43405 358 635 635.0 7KF:60901 Type1 Active DFGin 6.311 14.341 BLAminus -130.62, -177.29 62.11, 72.82 -94.96, 21.67 289.95, 80.8 -60.6, -26.94 in-in in 7.709 Saltbr-in 2.84 HRD-in -77.7, -52.28 69.96, 13.2 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.65, 88.09 APE9-dihe-in -107.14, 140.48 APE8-dihe-in -78.3, 78.38 APE8-rot-na 32.04 APE67-dihe-in -64.56, -15.37 -56.64, -35.35 APE12-dist-na 13.888 APE11-dist-na 10.557 APE10-dist-na 10.342 APE9-dist-in 6.849 None None None XRAY 1.77 0.208 0.234 A 289 270 8 0 0 0 [[370, 628]] 1.0 5tt7 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4FYOA P43405 363 635 635.0 0VF:60701 Type1 None DFGin 6.527 14.676 BLAminus -132.65, -177.95 62.23, 72.42 -93.99, 21.12 289.45, 90.18 -61.07, -25.58 in-in in 7.75 Saltbr-in 2.757 HRD-in -74.26, -50.97 72.76, 4.05 in-in-none SNCiin in-none ActLoopNT-in 2.952 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 140.05 APE9-dihe-in -108.11, 144.2 APE8-dihe-in -76.07, 73.27 APE8-rot-na 27.85 APE67-dihe-in -65.29, -14.44 -52.41, -38.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.947 APE9-dist-in 7.308 None None None XRAY 1.4 0.22 0.24 A 291 263 10 0 0 4 [[370, 628]] 1.0 4fyo Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4GFGA P43405 363 635 635.0 0XF:60701 Type1 Active DFGin 6.382 14.706 BLAminus -133.41, -165.6 61.44, 68.78 -94.44, 29.51 290.84, 74.86 -64.09, -30.1 in-in in 8.551 Saltbr-in 3.497 HRD-in -86.12, -47.8 68.36, 5.25 in-in-in SNCiii in-in ActLoopNT-in 2.866 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -53.12, 138.6 APE9-dihe-in -110.15, 137.21 APE8-dihe-in -65.63, 68.92 APE8-rot-na 25.72 APE67-dihe-in -68.08, -17.47 -52.98, -35.53 APE12-dist-na 9.582 APE11-dist-na 10.629 APE10-dist-na 11.706 APE9-dist-in 7.231 None None None XRAY 2.35 0.221 0.246 A 291 273 0 0 0 0 [[370, 628]] 1.0 4gfg Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5 260 256 511 512 513 515 517 402 420 424 491 493 492 494 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
CMGC MAPK14 MK14_MOUSE 5R9OA P47811 5 352 360.0 54F:401 Allosteric Inactive DFGin 7.673 17.211 BLBminus -136.39, -176.43 54.27, 60.09 -56.75, 144.98 283.51, 68.16 -67.8, 120.41 in-in in 9.802 Saltbr-in 2.875 HRD-in -68.65, -55.19 86.09, -8.85 in-out-out SNCioo out-out ActLoopNT-out 10.312 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.85, 133.85 APE9-dihe-na -63.65, -21.53 APE8-dihe-out -61.93, -15.63 APE8-rot-out 53.56 APE67-dihe-in -63.52, -19.95 -117.35, -20.3 APE12-dist-out 21.981 APE11-dist-out 24.156 APE10-dist-out 18.374 APE9-dist-out 11.868 None None None XRAY 1.6 0.18 0.196 A 360 348 0 0 0 0 [[24, 308]] 1.0 5r9o Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
TKL RIPK3 RIPK3_MOUSE 9LVHA Q9QZL0 13 312 486.0 MYF:401 Type1 None DFGin 6.25 14.259 BLAminus -136.98, 168.96 62.75, 89.32 -105.42, 15.63 293.79, 91.31 -62.49, -27.0 in-in in 8.376 Saltbr-in 2.879 HRD-in -72.81, -50.94 74.54, 2.05 in-in-none SNCiin in-none ActLoopNT-in 2.778 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -60.25, -26.93 999.0, -1.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.38 0.251 0.271 A 325 263 37 0 0 19 [[20, 290]] 1.0 9lvh Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9LVHB Q9QZL0 13 312 486.0 MYF:401 Type1 None DFGin 6.144 14.058 BLAminus -139.36, 174.01 57.76, 83.37 -93.9, 23.89 297.93, 87.69 -58.87, -31.82 in-in in 8.581 Saltbr-in 2.817 HRD-in -67.48, -56.31 78.93, 2.25 in-in-none SNCiin in-none ActLoopNT-in 2.713 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.93 APE8-rot-in 302.42 APE67-dihe-in -61.51, -26.08 -64.96, -15.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.38 0.251 0.271 B 325 266 34 0 0 18 [[20, 290]] 1.0 9lvh Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
OTHER CDC7 CDC7_YEAST 7PT78 P06243 10 475 507.0 ADP:1001,BEF:1003 ATPlike,Allosteric Inactive DFGin 7.05 14.828 ABAminus -125.48, -62.19 -62.72, 136.55 -132.76, 24.05 270.26, 81.1 -56.4, -43.64 in-out in 8.956 Saltbr-out 6.838 HRD-out -95.15, 91.19 -59.72, -45.2 out-in-out SNCoio in-out ActLoopNT-in 2.418 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiii APE10-dihe-na -63.65, 141.8 APE9-dihe-na 169.57, -141.23 APE8-dihe-in -138.07, 164.32 APE8-rot-in 301.9 APE67-dihe-out 82.72, -175.36 -64.25, 106.81 APE12-dist-in 8.854 APE11-dist-in 11.015 APE10-dist-in 5.043 APE9-dist-in 4.626 None None None EM 3.8 999.0 999.0 8 507 402 64 0 0 46 [[33, 469]] 1.0 7pt7 Saccharomyces cerevisiae OTHER_CDC7_YEAST CMGC 4e-17 121.0 1 158 260 181 182 183 185 187 76 90 94 160 162 161 163 301 288 283 282 281 280 279 278 277 121 Cell division control protein 7
CMGC GSK3B A0A125YY75_TOXGG 9HVXA A0A125YY75 46 384 394.0 A1IYF:60401 Type1 Inactive DFGin 6.812 13.739 BLAminus -151.79, -170.99 58.28, 71.83 -90.67, 23.31 282.96, 81.43 -68.24, -23.58 in-in in 7.973 Saltbr-in 2.67 HRD-in -79.27, -44.62 69.75, 6.05 in-in-out SNCiio in-out ActLoopNT-in 2.916 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.04, -39.68 APE9-dihe-na -85.38, 168.26 APE8-dihe-in -65.75, 139.05 APE8-rot-out 179.82 APE67-dihe-in -62.31, -27.06 -57.82, -44.69 APE12-dist-in 13.505 APE11-dist-in 11.868 APE10-dist-in 7.371 APE9-dist-in 3.499 None PTR211 PTR211 XRAY 2.1 0.203 0.25 A 350 323 16 0 0 0 [[47, 344]] 1.0 9hvx Toxoplasma gondii CMGC_GSK3B_TOXGG CMGC 6.4e-71 244.9 1 301 301 194 195 196 198 200 76 88 92 173 175 174 176 234 221 216 215 214 213 212 211 210 128 Putative cell-cycle-associated protein kinase GSK
CMGC GSK3B A0A125YY75_TOXGG 9HW6A A0A125YY75 46 384 394.0 A1IYF:60401 Type1 Inactive DFGin 6.554 13.514 BLAminus -159.29, -172.81 63.26, 75.9 -98.23, 18.12 289.64, 83.03 -60.9, -17.5 in-in in 8.248 Saltbr-in 2.913 HRD-in -74.22, -42.3 70.91, -2.75 in-in-out SNCiio in-out ActLoopNT-in 2.779 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_niio APE10-dihe-na -107.29, 145.01 APE9-dihe-na -102.07, 19.34 APE8-dihe-in -80.82, 138.15 APE8-rot-out 53.99 APE67-dihe-in -80.29, -18.75 -104.8, -54.34 APE12-dist-none 999.0 APE11-dist-in 10.111 APE10-dist-in 7.183 APE9-dist-out 8.805 None PTR211,SEP257 PTR211,SEP257 XRAY 2.9 0.207 0.26 A 373 332 7 0 0 3 [[47, 344]] 1.0 9hw6 Toxoplasma gondii CMGC_GSK3B_TOXGG CMGC 8e-71 244.6 1 301 301 194 195 196 198 200 76 88 92 173 175 174 176 234 221 216 215 214 213 212 211 210 128 Putative cell-cycle-associated protein kinase GSK
CMGC GSK3B A0A125YY75_TOXGG 9HW6B A0A125YY75 46 384 394.0 A1IYF:60402 Type1 Inactive DFGin 6.969 13.759 BLAminus -158.71, -175.52 61.04, 75.48 -97.8, 20.68 289.3, 83.48 -61.51, -18.44 in-in in 8.34 Saltbr-in 2.533 HRD-in -73.25, -38.58 70.21, -4.6 in-in-out SNCiio in-out ActLoopNT-in 2.957 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnio APE10-dihe-na 999.0, 137.93 APE9-dihe-na -128.88, -94.97 APE8-dihe-out 8.76, 102.73 APE8-rot-out 52.93 APE67-dihe-in -72.89, -15.66 -99.47, -15.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.673 APE9-dist-out 7.874 None PTR211 PTR211 XRAY 2.9 0.207 0.26 B 373 332 7 0 0 6 [[47, 344]] 1.0 9hw6 Toxoplasma gondii CMGC_GSK3B_TOXGG CMGC 8e-71 244.6 1 301 301 194 195 196 198 200 76 88 92 173 175 174 176 234 221 216 215 214 213 212 211 210 128 Putative cell-cycle-associated protein kinase GSK
CMGC GSK3B A0A125YY75_TOXGG 9HW6D A0A125YY75 46 384 394.0 A1IYF:60402 Type1 Inactive DFGin 6.752 13.545 BLAminus -157.98, -176.25 63.15, 72.4 -94.88, 18.71 288.21, 86.06 -60.77, -17.66 in-in in 8.448 Saltbr-in 3.001 HRD-in -74.85, -41.94 71.3, -1.92 in-in-out SNCiio in-out ActLoopNT-in 2.853 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnio APE10-dihe-na 999.0, -28.71 APE9-dihe-na 70.23, 60.42 APE8-dihe-out -136.17, -56.82 APE8-rot-out 132.32 APE67-dihe-out -77.45, -28.23 69.46, -39.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.077 APE9-dist-out 8.582 None PTR211,SEP257 PTR211,SEP257 XRAY 2.9 0.207 0.26 D 373 327 12 0 0 9 [[47, 344]] 1.0 9hw6 Toxoplasma gondii CMGC_GSK3B_TOXGG CMGC 8e-71 244.6 1 301 301 194 195 196 198 200 76 88 92 173 175 174 176 234 221 216 215 214 213 212 211 210 128 Putative cell-cycle-associated protein kinase GSK
CMGC GSK3B A0A125YY75_TOXGG 9HW6F A0A125YY75 46 384 394.0 A1IYF:60401 Type1 Inactive DFGin 6.98 13.82 BLAminus -156.62, -174.56 59.51, 71.39 -97.24, 16.48 288.27, 84.06 -60.16, -18.79 in-in in 8.206 Saltbr-in 2.735 HRD-in -76.38, -41.74 71.66, -4.7 in-in-out SNCiio in-out ActLoopNT-in 2.744 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_niio APE10-dihe-na -146.52, 154.45 APE9-dihe-na -92.11, 49.24 APE8-dihe-in -83.14, 134.37 APE8-rot-out 54.49 APE67-dihe-in -77.45, -15.85 -109.34, -69.31 APE12-dist-none 999.0 APE11-dist-in 9.936 APE10-dist-in 6.674 APE9-dist-out 9.042 None PTR211 PTR211 XRAY 2.9 0.207 0.26 F 373 325 14 0 0 6 [[47, 344]] 1.0 9hw6 Toxoplasma gondii CMGC_GSK3B_TOXGG CMGC 8e-71 244.6 1 301 301 194 195 196 198 200 76 88 92 173 175 174 176 234 221 216 215 214 213 212 211 210 128 Putative cell-cycle-associated protein kinase GSK

Ligand: F

Total number of chains: 13
Active chains: 1
Total number of genes: 6
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 8 61.5% 9RETA
DFGin ABAminus 2 15.4% 7PIEA
DFGout BBAminus 2 15.4% 5SYSA
DFGin BLBminus 1 7.7% 5R9OA

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC PRKACA KAPCA_CRIGR 7PIEA P25321 1 351 351.0 7QF:60401 Type1 Inactive DFGin 6.437 14.708 ABAminus -120.2, -32.0 -97.5, 116.46 -117.79, 21.67 284.38, 87.37 -67.96, -24.99 in-in in 9.018 Saltbr-in 2.947 HRD-in -90.08, -55.75 70.92, 8.29 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.9, 155.75 APE9-dihe-na 129.48, -166.45 APE8-dihe-in -116.19, 135.64 APE8-rot-in 298.32 APE67-dihe-in -59.08, -26.0 -47.12, -51.73 APE12-dist-in 8.298 APE11-dist-in 11.483 APE10-dist-in 5.921 APE9-dist-in 3.894 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.427 0.137 0.158 A 353 350 0 0 0 0 [[44, 298]] 1.0 7pie Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 9RETA P25321 13 351 351.0 A1JEF:60404 Allosteric Active DFGin 6.503 14.919 BLAminus -121.64, 161.02 79.66, 89.44 -97.28, 25.84 271.42, 57.67 -59.32, -29.98 in-in in 9.058 Saltbr-in 2.688 HRD-in -91.57, -50.28 65.7, 14.34 in-in-in SNCiii in-in ActLoopNT-in 2.961 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.82, 155.57 APE9-dihe-na 119.38, 155.92 APE8-dihe-in -73.83, 138.5 APE8-rot-in 315.72 APE67-dihe-in -57.32, -25.4 -54.39, -42.36 APE12-dist-in 8.186 APE11-dist-in 11.402 APE10-dist-in 5.952 APE9-dist-in 4.241 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.75 0.193 0.227 A 353 339 0 0 0 0 [[44, 298]] 1.0 9ret Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
TYR SRC SRC_CHICK 5SYSA P00523 258 533 533.0 72F:600 Type2 Inactive DFGout 13.354 9.801 BBAminus -126.48, -173.83 -168.38, 115.62 -104.78, -47.96 311.28, 146.33 163.56, 999.0 in-in in 8.579 Saltbr-in 3.03 HRD-in -86.37, -44.08 72.1, 11.73 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -16.31 APE8-rot-na 5.39 APE67-dihe-in -61.6, -39.03 -88.61, -20.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V281C None None XRAY 2.8 0.288 0.334 A 286 258 18 0 0 18 [[267, 518]] 1.0 5sys Gallus gallus TYR_SRC_CHICK TYR 4.2e-93 317.3 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 5SYSB P00523 258 533 533.0 72F:600 Type2 Inactive DFGout 13.413 10.163 BBAminus -126.31, -175.1 -166.31, 115.77 -103.34, -47.57 306.63, 130.98 67.96, 999.0 in-in in 8.321 Saltbr-in 3.044 HRD-in -86.54, -44.23 72.2, 11.45 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -18.84 APE8-rot-na 6.43 APE67-dihe-in -61.0, -39.73 -89.58, -19.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V281C None None XRAY 2.8 0.288 0.334 B 286 258 18 0 0 18 [[267, 518]] 1.0 5sys Gallus gallus TYR_SRC_CHICK TYR 4.2e-93 317.3 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
CMGC MAPK14 MK14_MOUSE 5R9OA P47811 5 352 360.0 54F:401 Allosteric Inactive DFGin 7.673 17.211 BLBminus -136.39, -176.43 54.27, 60.09 -56.75, 144.98 283.51, 68.16 -67.8, 120.41 in-in in 9.802 Saltbr-in 2.875 HRD-in -68.65, -55.19 86.09, -8.85 in-out-out SNCioo out-out ActLoopNT-out 10.312 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.85, 133.85 APE9-dihe-na -63.65, -21.53 APE8-dihe-out -61.93, -15.63 APE8-rot-out 53.56 APE67-dihe-in -63.52, -19.95 -117.35, -20.3 APE12-dist-out 21.981 APE11-dist-out 24.156 APE10-dist-out 18.374 APE9-dist-out 11.868 None None None XRAY 1.6 0.18 0.196 A 360 348 0 0 0 0 [[24, 308]] 1.0 5r9o Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
TKL RIPK3 RIPK3_MOUSE 9LVHA Q9QZL0 13 312 486.0 MYF:401 Type1 None DFGin 6.25 14.259 BLAminus -136.98, 168.96 62.75, 89.32 -105.42, 15.63 293.79, 91.31 -62.49, -27.0 in-in in 8.376 Saltbr-in 2.879 HRD-in -72.81, -50.94 74.54, 2.05 in-in-none SNCiin in-none ActLoopNT-in 2.778 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -60.25, -26.93 999.0, -1.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.38 0.251 0.271 A 325 263 37 0 0 19 [[20, 290]] 1.0 9lvh Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9LVHB Q9QZL0 13 312 486.0 MYF:401 Type1 None DFGin 6.144 14.058 BLAminus -139.36, 174.01 57.76, 83.37 -93.9, 23.89 297.93, 87.69 -58.87, -31.82 in-in in 8.581 Saltbr-in 2.817 HRD-in -67.48, -56.31 78.93, 2.25 in-in-none SNCiin in-none ActLoopNT-in 2.713 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.93 APE8-rot-in 302.42 APE67-dihe-in -61.51, -26.08 -64.96, -15.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.38 0.251 0.271 B 325 266 34 0 0 18 [[20, 290]] 1.0 9lvh Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3 265 263 160 161 162 164 166 51 61 65 140 142 141 143 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
OTHER CDC7 CDC7_YEAST 7PT78 P06243 10 475 507.0 ADP:1001,BEF:1003 ATPlike,Allosteric Inactive DFGin 7.05 14.828 ABAminus -125.48, -62.19 -62.72, 136.55 -132.76, 24.05 270.26, 81.1 -56.4, -43.64 in-out in 8.956 Saltbr-out 6.838 HRD-out -95.15, 91.19 -59.72, -45.2 out-in-out SNCoio in-out ActLoopNT-in 2.418 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiii APE10-dihe-na -63.65, 141.8 APE9-dihe-na 169.57, -141.23 APE8-dihe-in -138.07, 164.32 APE8-rot-in 301.9 APE67-dihe-out 82.72, -175.36 -64.25, 106.81 APE12-dist-in 8.854 APE11-dist-in 11.015 APE10-dist-in 5.043 APE9-dist-in 4.626 None None None EM 3.8 999.0 999.0 8 507 402 64 0 0 46 [[33, 469]] 1.0 7pt7 Saccharomyces cerevisiae OTHER_CDC7_YEAST CMGC 4e-17 121.0 1 158 260 181 182 183 185 187 76 90 94 160 162 161 163 301 288 283 282 281 280 279 278 277 121 Cell division control protein 7
CMGC GSK3B A0A125YY75_TOXGG 9HVXA A0A125YY75 46 384 394.0 A1IYF:60401 Type1 Inactive DFGin 6.812 13.739 BLAminus -151.79, -170.99 58.28, 71.83 -90.67, 23.31 282.96, 81.43 -68.24, -23.58 in-in in 7.973 Saltbr-in 2.67 HRD-in -79.27, -44.62 69.75, 6.05 in-in-out SNCiio in-out ActLoopNT-in 2.916 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.04, -39.68 APE9-dihe-na -85.38, 168.26 APE8-dihe-in -65.75, 139.05 APE8-rot-out 179.82 APE67-dihe-in -62.31, -27.06 -57.82, -44.69 APE12-dist-in 13.505 APE11-dist-in 11.868 APE10-dist-in 7.371 APE9-dist-in 3.499 None PTR211 PTR211 XRAY 2.1 0.203 0.25 A 350 323 16 0 0 0 [[47, 344]] 1.0 9hvx Toxoplasma gondii CMGC_GSK3B_TOXGG CMGC 6.4e-71 244.9 1 301 301 194 195 196 198 200 76 88 92 173 175 174 176 234 221 216 215 214 213 212 211 210 128 Putative cell-cycle-associated protein kinase GSK
CMGC GSK3B A0A125YY75_TOXGG 9HW6A A0A125YY75 46 384 394.0 A1IYF:60401 Type1 Inactive DFGin 6.554 13.514 BLAminus -159.29, -172.81 63.26, 75.9 -98.23, 18.12 289.64, 83.03 -60.9, -17.5 in-in in 8.248 Saltbr-in 2.913 HRD-in -74.22, -42.3 70.91, -2.75 in-in-out SNCiio in-out ActLoopNT-in 2.779 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_niio APE10-dihe-na -107.29, 145.01 APE9-dihe-na -102.07, 19.34 APE8-dihe-in -80.82, 138.15 APE8-rot-out 53.99 APE67-dihe-in -80.29, -18.75 -104.8, -54.34 APE12-dist-none 999.0 APE11-dist-in 10.111 APE10-dist-in 7.183 APE9-dist-out 8.805 None PTR211,SEP257 PTR211,SEP257 XRAY 2.9 0.207 0.26 A 373 332 7 0 0 3 [[47, 344]] 1.0 9hw6 Toxoplasma gondii CMGC_GSK3B_TOXGG CMGC 8e-71 244.6 1 301 301 194 195 196 198 200 76 88 92 173 175 174 176 234 221 216 215 214 213 212 211 210 128 Putative cell-cycle-associated protein kinase GSK
CMGC GSK3B A0A125YY75_TOXGG 9HW6B A0A125YY75 46 384 394.0 A1IYF:60402 Type1 Inactive DFGin 6.969 13.759 BLAminus -158.71, -175.52 61.04, 75.48 -97.8, 20.68 289.3, 83.48 -61.51, -18.44 in-in in 8.34 Saltbr-in 2.533 HRD-in -73.25, -38.58 70.21, -4.6 in-in-out SNCiio in-out ActLoopNT-in 2.957 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnio APE10-dihe-na 999.0, 137.93 APE9-dihe-na -128.88, -94.97 APE8-dihe-out 8.76, 102.73 APE8-rot-out 52.93 APE67-dihe-in -72.89, -15.66 -99.47, -15.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.673 APE9-dist-out 7.874 None PTR211 PTR211 XRAY 2.9 0.207 0.26 B 373 332 7 0 0 6 [[47, 344]] 1.0 9hw6 Toxoplasma gondii CMGC_GSK3B_TOXGG CMGC 8e-71 244.6 1 301 301 194 195 196 198 200 76 88 92 173 175 174 176 234 221 216 215 214 213 212 211 210 128 Putative cell-cycle-associated protein kinase GSK
CMGC GSK3B A0A125YY75_TOXGG 9HW6D A0A125YY75 46 384 394.0 A1IYF:60402 Type1 Inactive DFGin 6.752 13.545 BLAminus -157.98, -176.25 63.15, 72.4 -94.88, 18.71 288.21, 86.06 -60.77, -17.66 in-in in 8.448 Saltbr-in 3.001 HRD-in -74.85, -41.94 71.3, -1.92 in-in-out SNCiio in-out ActLoopNT-in 2.853 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnio APE10-dihe-na 999.0, -28.71 APE9-dihe-na 70.23, 60.42 APE8-dihe-out -136.17, -56.82 APE8-rot-out 132.32 APE67-dihe-out -77.45, -28.23 69.46, -39.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.077 APE9-dist-out 8.582 None PTR211,SEP257 PTR211,SEP257 XRAY 2.9 0.207 0.26 D 373 327 12 0 0 9 [[47, 344]] 1.0 9hw6 Toxoplasma gondii CMGC_GSK3B_TOXGG CMGC 8e-71 244.6 1 301 301 194 195 196 198 200 76 88 92 173 175 174 176 234 221 216 215 214 213 212 211 210 128 Putative cell-cycle-associated protein kinase GSK
CMGC GSK3B A0A125YY75_TOXGG 9HW6F A0A125YY75 46 384 394.0 A1IYF:60401 Type1 Inactive DFGin 6.98 13.82 BLAminus -156.62, -174.56 59.51, 71.39 -97.24, 16.48 288.27, 84.06 -60.16, -18.79 in-in in 8.206 Saltbr-in 2.735 HRD-in -76.38, -41.74 71.66, -4.7 in-in-out SNCiio in-out ActLoopNT-in 2.744 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_niio APE10-dihe-na -146.52, 154.45 APE9-dihe-na -92.11, 49.24 APE8-dihe-in -83.14, 134.37 APE8-rot-out 54.49 APE67-dihe-in -77.45, -15.85 -109.34, -69.31 APE12-dist-none 999.0 APE11-dist-in 9.936 APE10-dist-in 6.674 APE9-dist-out 9.042 None PTR211 PTR211 XRAY 2.9 0.207 0.26 F 373 325 14 0 0 6 [[47, 344]] 1.0 9hw6 Toxoplasma gondii CMGC_GSK3B_TOXGG CMGC 8e-71 244.6 1 301 301 194 195 196 198 200 76 88 92 173 175 174 176 234 221 216 215 214 213 212 211 210 128 Putative cell-cycle-associated protein kinase GSK