Ligand: F

Total number of chains: 168
Active chains: 39
Total number of genes: 62
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 78 46.4% 4AW0A
DFGin ABAminus 20 11.9% 4C57A
DFGin BLAplus 19 11.3% 9UHIA
DFGin None 16 9.5% 8B9EA
DFGin BLBplus 10 6.0% 3ZCLA
DFGout None 9 5.4% 3VO3A
DFGout BBAminus 8 4.8% 4MXCA
DFGin BLBminus 3 1.8% 5XYYA
DFGin BLBtrans 2 1.2% 2R3IA
None None 2 1.2% 5IEXA
DFGinter None 1 0.6% 4EBWA

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC AKT1 AKT1_HUMAN 4EKLA P31749 144 478 480.0 0RF:501 Type1 Active DFGin 6.4963 13.4232 BLAminus -130.08, 156.46 77.16, 99.77 -112.66, 14.16 298.65, 90.33 -61.32, -30.96 in-in in 8.9582 Saltbr-in 2.4524 HRD-in -78.38, -44.96 68.93, -13.6 in-in-in SNCiii in-in ActLoopNT-in 2.7571 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.83, 160.76 APE9-dihe-na 116.71, 166.32 APE8-dihe-in -83.66, 133.51 APE8-rot-in 293.53 APE67-dihe-in -68.09, -18.95 -43.13, -46.31 APE12-dist-in 8.36 APE11-dist-in 11.5119 APE10-dist-in 6.0113 APE9-dist-in 4.4431 S473D TPO308 TPO308 XRAY 2.0 0.175 0.235 A 341.0 330.0 0 28 28 0 [[150, 408]] 1.0 4ekl AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC GRK5 GRK5_HUMAN 9BRPA P34947 25 542 590.0 A1ARF:601 Type1 Inactive DFGin 6.2535 12.4795 ABAminus -116.3, -61.02 -91.04, 101.81 -97.25, 10.66 289.92, 84.11 -59.57, -18.7 in-in in 8.9098 Saltbr-in 3.0371 HRD-in -85.07, -56.86 71.89, 13.22 in-in-in SNCiii in-in ActLoopNT-in 3.1048 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.18, 177.63 APE9-dihe-na 122.23, -155.28 APE8-dihe-in -122.73, 136.27 APE8-rot-in 286.0 APE67-dihe-inflip 100.9, -21.88 -54.82, 128.22 APE12-dist-in 9.574 APE11-dist-in 11.9322 APE10-dist-in 6.253 APE9-dist-in 4.143 D311N None None XRAY 2.8 0.245 0.283 A 598.0 502.0 0 27 27 0 [[186, 448]] 1.0 9brp AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BREA P34947 25 542 590.0 W3F:601 Type1 Active DFGin 6.1758 12.5641 BLAminus -128.67, 172.15 57.35, 77.75 -93.22, 24.8 286.17, 72.14 -63.15, -21.99 in-in in 8.8006 Saltbr-in 2.4578 HRD-in -88.2, -51.09 67.29, 13.94 in-in-in SNCiii in-in ActLoopNT-in 3.1273 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.49, 165.19 APE9-dihe-na 125.58, -150.88 APE8-dihe-in -124.55, 138.39 APE8-rot-in 312.36 APE67-dihe-inflip 92.11, -16.19 -53.44, 132.83 APE12-dist-in 9.9432 APE11-dist-in 12.1314 APE10-dist-in 6.3367 APE9-dist-in 4.1222 D311N None None XRAY 2.8 0.215 0.26 A 598.0 503.0 0 27 27 0 [[186, 448]] 1.0 9bre AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 8UAQA P34947 25 542 590.0 W3F:601 Type1 Inactive DFGin 6.0198 12.8412 None -112.48, -65.82 -86.97, 96.33 -93.06, 17.75 286.66, 70.13 -64.2, -19.76 in-in in 9.3335 Saltbr-in 3.3688 HRD-in -90.24, -57.5 70.99, -0.54 in-in-in SNCiii in-in ActLoopNT-in 3.0372 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.56, 170.13 APE9-dihe-na 119.68, -157.85 APE8-dihe-in -112.7, 143.6 APE8-rot-in 314.4 APE67-dihe-inflip 89.64, -4.73 -59.54, 131.81 APE12-dist-in 9.916 APE11-dist-in 12.1019 APE10-dist-in 6.3064 APE9-dist-in 4.1737 D311N None None XRAY 2.8 0.232 0.277 A 598.0 501.0 0 27 27 0 [[186, 448]] 1.0 8uaq AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC PDPK1 PDPK1_HUMAN 4AW0A O15530 75 359 556.0 ATP:500,MJF:600 ATPlike,Allosteric Active DFGin 6.5313 14.9926 BLAminus -134.84, 177.25 78.73, 76.19 -106.3, 8.53 283.51, 97.11 -69.63, -19.36 in-in in 8.5954 Saltbr-in 3.0091 HRD-in -83.05, -53.03 79.45, -12.94 in-in-in SNCiii in-in ActLoopNT-in 2.9336 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.69, 159.04 APE9-dihe-na 139.48, -167.8 APE8-dihe-in -131.87, 132.42 APE8-rot-in 295.45 APE67-dihe-in -61.29, -25.28 -54.74, -42.17 APE12-dist-in 7.5089 APE11-dist-in 10.6011 APE10-dist-in 5.0264 APE9-dist-in 3.5797 Y288G,Q292A SEP241 SEP241,CME260 XRAY 1.43 0.171 0.188 A 311.0 285.0 0 30 30 0 [[82, 342]] 1.0 4aw0 AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PRKCH KPCL_HUMAN 8FP1A P24723 349 676 683.0 XXF:9000 Type1 Active DFGin 6.0402 12.8612 BLAminus -134.17, 160.39 76.6, 103.68 -113.44, 14.82 306.37, 103.97 -62.81, -37.48 in-in in 8.5287 Saltbr-in 2.747 HRD-in -71.28, -48.4 60.66, 8.21 in-in-in SNCiii in-in ActLoopNT-in 3.0416 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -168.52, 169.89 APE9-dihe-na 121.68, 166.05 APE8-dihe-in -83.39, 128.15 APE8-rot-in 297.95 APE67-dihe-in -61.25, -27.98 -43.8, -44.17 APE12-dist-in 8.6657 APE11-dist-in 11.7009 APE10-dist-in 6.3651 APE9-dist-in 3.5655 S675E TPO513,TPO656 TPO513,TPO656 XRAY 1.85 0.2 0.234 A 353.0 328.0 0 28 28 0 [[355, 614]] 1.0 8fp1 AGC_PRKCH_HUMAN AGC 1.6e-97 331.6 1.0 260.0 260.0 496 497 498 500 502 384 403 407 476 478 477 479.0 536 524 519 518 517 516 515 514 513 434 Protein kinase C eta type
CAMK AURKA AURKA_HUMAN 8C1DA O14965 127 388 403.0 T2F:401,ADP:402,T5L:405 Allosteric,ATPlike,Allosteric Inactive DFGin 5.5903 14.7701 BLAminus -129.39, 179.64 57.3, 80.97 -92.88, 23.53 280.13, 79.47 -56.16, -33.44 in-in in 9.3061 Saltbr-in 2.9364 HRD-in -72.1, -50.49 67.69, -1.24 in-in-out SNCiio in-out ActLoopNT-in 2.7964 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 144.85 APE8-dihe-in -64.26, 154.27 APE8-rot-out 88.6 APE67-dihe-in -39.49, -36.75 -82.32, -6.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.088 C290A None None XRAY 2.115 0.212 0.238 A 265.0 259.0 3 26 23 3 [[133, 383]] 1.0 8c1d CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2W1FA O14965 127 389 403.0 L0F:61390 Type1 Inactive DFGin 5.6549 15.7027 BLAminus -96.26, 172.45 62.06, 107.69 -118.91, 38.89 289.12, 66.42 -59.62, -48.4 out-out out 10.1385 Saltbr-out 5.1197 HRD-in -78.79, -54.88 78.03, -25.41 out-in-out SNCoio in-out ActLoopNT-in 2.6762 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -157.03 APE8-dihe-in -58.47, 105.92 APE8-rot-out 190.33 APE67-dihe-in -42.4, -27.58 -64.36, -20.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7745 None None None XRAY 2.85 0.246 0.348 A 275.0 253.0 10 26 16 10 [[133, 383]] 1.0 2w1f CAMK_AURKA_HUMAN CAMK 6.7e-80 274.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3O51A O14965 126 388 403.0 LJF:1 Type1.5_Front Inactive DFGout 12.9209 9.2148 None -125.94, 46.56 -78.14, 156.47 -164.09, 999.0 59.42, 112.33 999.0, 999.0 out-none out 12.8625 Saltbr-none 999.0 HRD-out -126.02, 153.87 -92.88, -115.51 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -57.91, -10.7 999.0, -51.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.288 0.304 A 267.0 246.0 17 26 9 17 [[133, 383]] 1.0 3o51 CAMK_AURKA_HUMAN CAMK 6e-80 274.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK CAMK2A KCC2A_HUMAN 2VZ6A Q9UQM7 9 299 478.0 FEF:60600 Type1 Active DFGin 7.1238 13.9304 BLAminus -130.3, 144.9 77.59, 104.3 -118.45, 37.91 281.19, 70.53 -60.86, -31.43 in-in in 9.0324 Saltbr-in 2.6227 HRD-in -71.43, -45.76 75.34, -9.9 in-in-in SNCiii in-in ActLoopNT-in 2.8051 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.76, 148.02 APE9-dihe-na 132.07, -168.34 APE8-dihe-in -120.79, 126.49 APE8-rot-in 299.71 APE67-dihe-in -63.07, -18.83 -35.01, -58.7 APE12-dist-in 10.327 APE11-dist-in 11.8194 APE10-dist-in 5.9929 APE9-dist-in 3.8322 None None None XRAY 2.3 0.165 0.203 A 313.0 289.0 2 28 28 0 [[13, 271]] 1.0 2vz6 CAMK_CAMK2A_HUMAN CAMK 1.6e-96 328.7 1.0 256.0 256.0 155 156 157 159 161 42 60 64 132 134 133 135.0 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 2VZ6B Q9UQM7 9 300 478.0 FEF:60600 Type1 Active DFGin 6.8653 14.0317 BLAminus -131.92, 139.26 77.54, 110.88 -122.08, 32.95 286.68, 71.96 -61.55, -26.54 in-in in 9.3105 Saltbr-in 2.9307 HRD-in -73.12, -44.65 73.93, -20.22 in-in-in SNCiii in-in ActLoopNT-in 2.8744 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.21, 149.78 APE9-dihe-na 143.11, -171.05 APE8-dihe-in -118.3, 128.44 APE8-rot-in 303.95 APE67-dihe-in -66.72, -18.78 -39.97, -52.82 APE12-dist-in 10.2519 APE11-dist-in 11.7563 APE10-dist-in 5.9962 APE9-dist-in 3.963 None None None XRAY 2.3 0.165 0.203 B 313.0 292.0 0 28 28 0 [[13, 271]] 1.0 2vz6 CAMK_CAMK2A_HUMAN CAMK 1.6e-96 328.7 1.0 256.0 256.0 155 156 157 159 161 42 60 64 132 134 133 135.0 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CHEK1 CHK1_HUMAN 8E80A O14757 8 271 476.0 UUF:301 Type1 Active DFGin 6.9481 13.5611 BLAminus -116.38, 163.51 69.37, 105.0 -111.89, 20.17 292.16, 81.73 -65.53, -30.68 in-in in 8.5794 Saltbr-in 2.859 HRD-in -73.57, -45.75 72.69, 0.21 in-in-in SNCiii in-in ActLoopNT-in 2.9485 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.33, 170.54 APE9-dihe-na 117.83, -149.18 APE8-dihe-in -134.92, 121.74 APE8-rot-in 303.05 APE67-dihe-in -62.91, -20.27 -44.12, -51.23 APE12-dist-in 9.3649 APE11-dist-in 11.6442 APE10-dist-in 6.1424 APE9-dist-in 3.4974 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.49 0.209 0.242 A 297.0 258.0 6 30 30 0 [[9, 265]] 1.0 8e80 CAMK_CHEK1_HUMAN CAMK 4.8e-69 238.4 2.0 256.0 255.0 147 148 149 151 153 38 55 59 127 129 128 130.0 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK2 CHK2_HUMAN 2YCFA O96017 210 510 543.0 YCF:600 Type1 Inactive DFGin 6.6505 14.4245 BLAminus -133.14, 179.08 68.92, 89.26 -105.02, 26.49 290.18, 77.38 -65.99, -23.19 in-out in 9.994 Saltbr-out 8.5603 HRD-in -70.72, -52.98 75.15, -0.9 out-in-out SNCoio in-out ActLoopNT-in 2.9054 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -72.28, -26.54 APE9-dihe-na -96.81, -179.54 APE8-dihe-in -85.38, 132.85 APE8-rot-in 297.44 APE67-dihe-in -44.53, -40.92 -82.1, 28.65 APE12-dist-out 25.2308 APE11-dist-out 27.2893 APE10-dist-out 29.3634 APE9-dist-out 33.1045 None None None XRAY 1.77 0.197 0.218 A 322.0 286.0 15 27 27 0 [[220, 486]] 1.0 2ycf CAMK_CHEK2_HUMAN CAMK 2e-85 292.2 1.0 256.0 256.0 367 368 369 371 373 249 273 277 344 346 345 347.0 409 394 389 388 387 386 385 384 383 302 Serine/threonine-protein kinase Chk2
CAMK DAPK1 DAPK1_HUMAN 6AARA P53355 2 277 1430.0 9TF:300 Type1 Inactive DFGin 6.7434 14.3416 BLAminus -121.31, 178.32 64.29, 78.62 -87.38, 15.28 286.92, 75.84 -59.31, -26.74 in-in in 9.3863 Saltbr-in 2.8106 HRD-in -76.03, -46.41 70.92, -12.19 in-in-out SNCiio in-out ActLoopNT-in 2.9205 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -137.91, 116.13 APE9-dihe-na -97.58, -145.9 APE8-dihe-in -81.4, 124.5 APE8-rot-in 302.0 APE67-dihe-in -55.21, -31.9 -47.73, -42.04 APE12-dist-in 11.0192 APE11-dist-out 6.2597 APE10-dist-out 9.242 APE9-dist-in 4.8049 None None None XRAY 1.95 0.182 0.22 A 293.0 269.0 7 27 27 0 [[13, 275]] 1.0 6aar CAMK_DAPK1_HUMAN CAMK 6.1e-95 323.3 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK MAPKAPK2 MAPK2_HUMAN 3M42A P49137 47 364 400.0 HGF:365 Type1 None DFGin 4.2648 13.7652 BLAminus -127.28, 170.7 71.87, 101.44 -103.87, 20.75 277.01, 69.5 -61.92, -8.22 in-in in 9.2598 Saltbr-in 3.0911 HRD-in -73.72, -58.45 76.25, 11.76 in-in-none SNCiin in-none ActLoopNT-in 2.9117 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 P237G None None XRAY 2.68 0.186 0.232 A 299.0 290.0 7 -206 -206 0 [[63, 325]] 1.0 3m42 CAMK_MAPKAPK2_HUMAN CAMK 1.9e-36 228.6 3.0 154.0 236.0 206 207 208 210 212 93 104 108 183 185 184 186.0 245 0 0 0 0 0 0 0 0 139 MAP kinase-activated protein kinase 2
CAMK MELK MELK_HUMAN 5IH9A Q14680 3 327 651.0 6BF:60401 Type1 None DFGin 6.9392 15.1461 BLAminus -123.48, 176.08 58.26, 79.91 -95.72, 21.84 280.98, 78.3 -67.92, -25.97 in-in in 8.7195 Saltbr-in 2.5866 HRD-in -71.83, -48.59 72.02, -0.04 in-in-none SNCiin in-none ActLoopNT-in 2.9916 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -4.81 APE8-rot-in 291.01 APE67-dihe-in -55.95, -27.86 -55.75, -43.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.79 0.174 0.2 A 335.0 307.0 18 29 15 14 [[11, 263]] 1.0 5ih9 CAMK_MELK_HUMAN CAMK 9.7e-89 303.1 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK PIM1 PIM1_HUMAN 5KGIA P11309 33 305 313.0 6SF:414 Type1 Active DFGin 6.1959 14.6781 BLAminus -128.85, 173.72 58.37, 80.83 -91.15, 15.65 283.15, 78.86 -67.29, -15.19 in-in in 8.8975 Saltbr-in 2.6991 HRD-naA -66.85, -48.52 69.49, 3.32 in-in-in SNCiii in-in ActLoopNT-in 2.8537 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.48, 30.3 APE9-dihe-na -88.67, -155.26 APE8-dihe-in -89.24, 121.14 APE8-rot-in 310.96 APE67-dihe-in -66.24, -12.88 -55.29, -44.34 APE12-dist-in 9.7233 APE11-dist-in 8.7346 APE10-dist-in 5.6424 APE9-dist-in 3.7397 None None None XRAY 2.13 0.173 0.186 A 276.0 273.0 0 26 26 0 [[38, 290]] 1.0 5kgi CAMK_PIM1_HUMAN CAMK 2.5e-65 226.2 1.0 256.0 256.0 185 186 187 189 191 67 89 93 164 166 165 167.0 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 6L13A P11309 33 305 313.0 E2F:401 Type1 Active DFGin 6.1902 14.7858 BLAminus -130.24, 168.2 68.46, 80.68 -89.17, 16.05 288.1, 80.31 -69.01, -19.61 in-in in 9.1055 Saltbr-in 2.9362 HRD-naA -68.46, -51.8 71.9, 8.52 in-in-in SNCiii in-in ActLoopNT-in 2.7778 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.76, 29.56 APE9-dihe-na -92.34, -153.25 APE8-dihe-in -98.43, 124.2 APE8-rot-in 303.55 APE67-dihe-in -68.48, -12.49 -58.68, -45.06 APE12-dist-in 9.5 APE11-dist-in 8.5109 APE10-dist-in 5.0987 APE9-dist-in 3.6586 None SEP261 SEP261 XRAY 2.24 0.18 0.214 A 289.0 273.0 0 26 26 0 [[38, 290]] 1.0 6l13 CAMK_PIM1_HUMAN CAMK 3e-65 226.0 1.0 256.0 256.0 185 186 187 189 191 67 89 93 164 166 165 167.0 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 2O65A P11309 33 306 313.0 MYF:501 Type1 Active DFGin 5.7731 14.2228 BLAminus -134.9, 170.04 60.08, 89.22 -101.35, 10.62 287.34, 92.73 -63.96, -9.9 in-in in 8.7039 Saltbr-in 2.4715 HRD-naA -65.14, -47.59 70.03, -4.07 in-in-in SNCiii in-in ActLoopNT-in 2.9803 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.66, 34.64 APE9-dihe-na -104.35, -148.26 APE8-dihe-in -83.11, 121.1 APE8-rot-in 316.59 APE67-dihe-in -62.15, -16.44 -57.04, -47.52 APE12-dist-in 9.9881 APE11-dist-in 8.6279 APE10-dist-in 5.2887 APE9-dist-in 4.1355 None None None XRAY 2.85 0.21 0.262 A 293.0 274.0 0 26 26 0 [[38, 290]] 1.0 2o65 CAMK_PIM1_HUMAN CAMK 3.2e-65 226.0 1.0 256.0 256.0 185 186 187 189 191 67 89 93 164 166 165 167.0 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 8R0WA P11309 33 305 313.0 XGF:405 Type1 Active DFGin 5.9965 14.3841 BLAminus -131.73, 166.77 65.97, 82.46 -89.79, 16.41 289.35, 79.56 -63.02, -16.4 in-in in 8.8117 Saltbr-in 2.6426 HRD-naA -73.15, -45.35 65.43, 10.88 in-in-in SNCiii in-in ActLoopNT-in 2.8554 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.23, 17.26 APE9-dihe-na -81.93, -156.28 APE8-dihe-in -91.39, 121.88 APE8-rot-in 296.84 APE67-dihe-in -71.92, -8.94 -64.52, -38.27 APE12-dist-in 9.5591 APE11-dist-in 8.4794 APE10-dist-in 5.1163 APE9-dist-in 3.7129 R250G SEP261 SEP261 XRAY 1.95 0.167 0.201 A 313.0 273.0 0 26 26 0 [[38, 290]] 1.0 8r0w CAMK_PIM1_HUMAN CAMK 1.5e-64 223.7 1.0 256.0 256.0 185 186 187 189 191 67 89 93 164 166 165 167.0 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 8AFRA P11309 33 305 313.0 M0F:401 Type1 Active DFGin 6.0243 14.4056 BLAminus -126.46, 177.16 55.61, 83.44 -89.48, 19.88 284.93, 74.96 -67.33, -13.52 in-in in 8.8307 Saltbr-in 2.6484 HRD-naA -72.52, -48.51 66.56, 10.77 in-in-in SNCiii in-in ActLoopNT-in 2.8149 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.4, 19.87 APE9-dihe-na -78.39, -149.93 APE8-dihe-in -97.85, 123.61 APE8-rot-in 301.25 APE67-dihe-in -68.16, -10.25 -64.9, -40.75 APE12-dist-in 9.7271 APE11-dist-in 8.4666 APE10-dist-in 5.304 APE9-dist-in 3.645 R250G SEP261 SEP261 XRAY 2.15 0.166 0.191 A 309.0 264.0 7 26 26 0 [[38, 290]] 1.0 8afr CAMK_PIM1_HUMAN CAMK 3.1e-62 216.2 1.0 256.0 256.0 185 186 187 189 191 67 89 93 164 166 165 167.0 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CMGC CDK12 CDK12_HUMAN 8BU5B Q9NYV4 713 1044 1490.0 RMF:1101 Type1 Inactive DFGin 6.8015 14.7007 ABAminus -126.95, -66.04 -93.95, 105.24 -102.41, 30.18 293.69, 100.66 -84.84, -22.58 in-out in 8.3047 Saltbr-out 3.9335 HRD-out -78.59, 106.12 -94.17, 5.74 out-in-out SNCoio in-out ActLoopNT-in 2.8278 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -136.91, -22.25 APE9-dihe-na -109.89, 157.52 APE8-dihe-in -56.01, 131.78 APE8-rot-in 308.02 APE67-dihe-in -60.99, -26.61 -52.03, -40.26 APE12-dist-out 14.2801 APE11-dist-in 11.9408 APE10-dist-in 7.3604 APE9-dist-in 3.7666 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 B 344.0 332.0 0 29 29 0 [[727, 1020]] 1.0 8bu5 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU5H Q9NYV4 713 1043 1490.0 RMF:1101 Type1 Inactive DFGin 7.0152 14.9781 ABAminus -128.46, -54.53 -90.71, 103.12 -97.22, 31.8 290.43, 81.59 -85.33, -25.69 in-in in 8.4795 Saltbr-in 3.5275 HRD-in -73.55, -49.58 63.85, -4.76 in-in-in SNCiii in-in ActLoopNT-in 2.6292 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.5, -28.02 APE9-dihe-na -97.36, 153.71 APE8-dihe-in -57.72, 135.61 APE8-rot-in 311.07 APE67-dihe-in -63.38, -27.52 -50.57, -39.59 APE12-dist-in 13.9415 APE11-dist-in 12.128 APE10-dist-in 7.2577 APE9-dist-in 3.4973 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 H 344.0 331.0 0 29 29 0 [[727, 1020]] 1.0 8bu5 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUNB Q9NYV4 715 1041 1490.0 RNF:61101 Type1 Inactive DFGin 7.0092 15.2967 ABAminus -131.36, -49.43 -89.83, 91.44 -92.44, 32.63 287.3, 77.5 -75.27, -18.22 in-in in 7.7476 Saltbr-in 3.2793 HRD-in -75.67, -53.71 75.4, -0.11 in-in-in SNCiii in-in ActLoopNT-in 2.9232 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -107.12, -39.12 APE9-dihe-na -104.98, 151.97 APE8-dihe-in -58.93, 142.91 APE8-rot-in 279.94 APE67-dihe-in -65.42, -33.6 -55.06, -35.14 APE12-dist-in 13.3877 APE11-dist-in 11.6951 APE10-dist-in 7.099 APE9-dist-in 3.6569 K965R TPO893 TPO893 XRAY 3.08 0.187 0.211 B 344.0 327.0 0 29 29 0 [[727, 1020]] 1.0 8bun CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUNH Q9NYV4 715 1043 1490.0 RNF:61101 Type1 Inactive DFGin 7.0453 15.2864 ABAminus -125.24, -50.09 -100.69, 94.75 -92.24, 30.97 286.18, 71.82 -75.42, -18.26 in-in in 7.8338 Saltbr-in 3.3735 HRD-in -77.6, -54.36 73.0, -1.25 in-in-in SNCiii in-in ActLoopNT-in 2.74 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.56, -41.65 APE9-dihe-na -95.79, 153.05 APE8-dihe-in -58.87, 144.43 APE8-rot-in 305.25 APE67-dihe-in -65.98, -31.29 -55.83, -37.71 APE12-dist-in 13.7752 APE11-dist-in 11.9719 APE10-dist-in 6.9568 APE9-dist-in 3.4785 K965R TPO893 TPO893 XRAY 3.08 0.187 0.211 H 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bun CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 9FMRE Q9NYV4 714 1042 1490.0 RMF:61101 Type1 Inactive DFGin 6.7935 14.6403 ABAminus -113.83, -79.52 -84.15, 118.47 -115.27, 16.16 293.54, 100.02 -64.02, -34.33 in-out in 9.6335 Saltbr-out 3.6123 HRD-out -79.17, 82.22 -59.96, 8.89 out-in-out SNCoio in-out ActLoopNT-in 3.0256 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -148.14, -27.51 APE9-dihe-na -104.44, 148.12 APE8-dihe-in -51.45, 137.55 APE8-rot-in 306.02 APE67-dihe-in -70.5, -21.3 -54.61, -36.19 APE12-dist-out 14.2984 APE11-dist-in 12.2112 APE10-dist-in 7.469 APE9-dist-in 3.7666 None TPO893 TPO893 XRAY 3.9 0.209 0.25 E 351.0 329.0 0 29 29 0 [[727, 1020]] 1.0 9fmr CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 9FMRH Q9NYV4 714 1044 1490.0 RMF:61101 Type1 Inactive DFGin 6.8012 14.6033 ABAminus -113.95, -78.4 -84.85, 124.02 -118.87, 17.95 291.29, 89.7 -63.88, -35.4 in-in in 8.5917 Saltbr-in 3.5517 HRD-in -72.47, -40.65 59.82, 5.57 in-in-in SNCiii in-in ActLoopNT-in 2.9439 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.74, -27.71 APE9-dihe-na -103.25, 148.34 APE8-dihe-in -51.07, 136.63 APE8-rot-in 306.14 APE67-dihe-in -69.99, -21.15 -54.39, -34.8 APE12-dist-in 13.8232 APE11-dist-in 12.0979 APE10-dist-in 7.2545 APE9-dist-in 3.6076 None TPO893 TPO893 XRAY 3.9 0.209 0.25 H 351.0 331.0 0 29 29 0 [[727, 1020]] 1.0 9fmr CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUNE Q9NYV4 715 1039 1490.0 RNF:61101 Type1 Inactive DFGin 7.2173 15.3129 BLAminus -143.55, -179.06 50.55, 77.42 -92.12, 34.85 285.27, 76.47 -72.26, -18.51 in-in in 7.8237 Saltbr-in 3.0461 HRD-in -77.13, -53.65 75.0, -0.22 in-in-out SNCiio in-out ActLoopNT-in 2.9239 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -105.31, -34.23 APE9-dihe-na -92.08, 151.91 APE8-dihe-in -57.84, 145.99 APE8-rot-out 175.35 APE67-dihe-in -65.98, -29.37 -55.72, -38.5 APE12-dist-in 13.1801 APE11-dist-in 12.6112 APE10-dist-in 7.008 APE9-dist-in 3.4323 K965R TPO893 TPO893 XRAY 3.08 0.187 0.211 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bun CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8P81A Q9NYV4 716 1035 1490.0 RMF:1101 Type1 Active DFGin 7.0954 14.4463 BLAminus -134.83, -178.64 59.2, 72.19 -89.53, 34.88 291.56, 80.44 -67.97, -22.73 in-in in 8.3586 Saltbr-in 3.0568 HRD-in -81.5, -42.97 59.01, 18.94 in-in-in SNCiii in-in ActLoopNT-in 2.9629 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.63, 165.61 APE9-dihe-na 67.08, 139.25 APE8-dihe-in -61.99, 152.33 APE8-rot-in 316.49 APE67-dihe-in -68.12, -20.85 -57.98, -41.98 APE12-dist-in 12.6789 APE11-dist-in 10.561 APE10-dist-in 6.5202 APE9-dist-in 3.2122 None TPO893 TPO893 XRAY 2.68 0.212 0.255 A 351.0 320.0 0 29 29 0 [[727, 1020]] 1.0 8p81 CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU5E Q9NYV4 713 1043 1490.0 RMF:1101 Type1 Inactive DFGin 6.9424 15.1221 None -123.64, -63.66 -81.97, -51.09 56.28, 22.54 292.49, 98.9 -91.33, -28.22 in-out in 8.3713 Saltbr-out 3.6222 HRD-in -72.77, -54.57 74.45, -4.91 out-in-out SNCoio in-out ActLoopNT-in 2.7589 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -134.16, -27.33 APE9-dihe-na -98.05, 157.33 APE8-dihe-in -51.55, 136.25 APE8-rot-in 308.17 APE67-dihe-in -63.16, -26.85 -49.17, -41.17 APE12-dist-out 14.1246 APE11-dist-in 12.1682 APE10-dist-in 7.2856 APE9-dist-in 3.7263 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 E 344.0 331.0 0 29 29 0 [[727, 1020]] 1.0 8bu5 CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 9FMRB Q9NYV4 714 1047 1490.0 RMF:61101 Type1 Inactive DFGin 7.1242 15.0312 None -111.49, -74.26 -77.99, -72.15 68.85, 12.84 296.16, 89.8 -66.22, -36.51 in-out in 8.3316 Saltbr-out 4.4499 HRD-in -70.8, -35.56 62.81, 1.22 out-in-in SNCoii in-in ActLoopNT-in 3.0722 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.03, -25.75 APE9-dihe-na -103.56, 146.88 APE8-dihe-in -51.72, 138.27 APE8-rot-in 305.58 APE67-dihe-in -69.51, -21.36 -53.61, -35.19 APE12-dist-in 13.9874 APE11-dist-in 12.2701 APE10-dist-in 7.331 APE9-dist-in 3.8645 None TPO893 TPO893 XRAY 3.9 0.209 0.25 B 351.0 334.0 0 29 29 0 [[727, 1020]] 1.0 9fmr CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK16 CDK16_HUMAN 3MTLA Q00536 163 473 496.0 FEF:60668 Type1 Inactive DFGout 17.3993 7.4716 None -75.13, 154.32 -88.9, 77.74 -154.62, 116.54 227.56, 88.74 78.03, 21.89 in-in in 8.3848 Saltbr-in 2.6411 HRD-out -101.69, 108.56 -74.19, -25.04 in-out-out SNCioo out-out ActLoopNT-out 5.1638 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 102.89 APE8-rot-out 156.53 APE67-dihe-in -61.54, -35.29 -78.56, -14.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S319D None None XRAY 2.4 0.198 0.263 A 324.0 293.0 18 28 16 12 [[165, 446]] 1.0 3mtl CMGC_CDK16_HUMAN CMGC 1.3e-83 286.9 1.0 301.0 301.0 303 304 305 307 309 194 211 215 283 285 284 286.0 344 331 326 325 324 323 322 321 320 241 Cyclin-dependent kinase 16
CMGC CDK2 CDK2_HUMAN 9ESWA P24941 1 294 298.0 IJF:60301,IJF:60302,IJF:60303,IJF:60304 Allosteric,Type1,Allosteric,Allosteric Active DFGin 6.5148 15.2974 BLAminus -143.94, 174.07 58.52, 82.55 -94.4, 25.35 278.47, 68.95 -74.76, -22.16 in-in in 8.6366 Saltbr-in 3.1971 HRD-in -81.26, -58.57 77.56, 16.21 in-in-in SNCiii in-in ActLoopNT-in 2.9956 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -61.44, 160.94 APE9-dihe-na 81.67, 126.4 APE8-dihe-in -51.25, 136.17 APE8-rot-in 300.7 APE67-dihe-in -59.48, -16.12 -52.59, -48.63 APE12-dist-in 12.9968 APE11-dist-in 11.8966 APE10-dist-in 7.0228 APE9-dist-in 3.2038 None TPO160 TPO160 XRAY 2.38 0.233 0.239 A 302.0 294.0 0 28 28 0 [[4, 286]] 1.0 9esw CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9ESWC P24941 1 296 298.0 IJF:60301,IJF:60302,IJF:60303,IJF:60304 Allosteric,Type1,Allosteric,Allosteric Active DFGin 6.5764 15.209 BLAminus -137.9, -176.23 48.55, 71.41 -85.05, 25.18 283.44, 66.65 -62.35, -32.95 in-in in 8.4167 Saltbr-in 2.7633 HRD-in -83.58, -58.72 75.84, 9.9 in-in-in SNCiii in-in ActLoopNT-in 2.887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.32, 151.2 APE9-dihe-na 72.23, 131.64 APE8-dihe-in -58.77, 140.82 APE8-rot-in 312.4 APE67-dihe-in -51.92, -26.23 -42.04, -57.02 APE12-dist-in 12.7761 APE11-dist-in 10.1953 APE10-dist-in 6.9433 APE9-dist-in 3.2364 None TPO160 TPO160 XRAY 2.38 0.233 0.239 C 302.0 269.0 27 28 28 0 [[4, 286]] 1.0 9esw CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9OB4A P24941 1 298 298.0 A1CAF:301 Type1 Active DFGin 7.0696 15.4326 BLAminus -140.78, 171.16 58.81, 81.21 -94.48, 18.25 279.35, 70.51 -60.63, -24.89 in-in in 8.7019 Saltbr-in 2.5781 HRD-in -77.49, -52.8 70.85, 9.99 in-in-in SNCiii in-in ActLoopNT-in 2.8582 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -103.4, 171.78 APE9-dihe-na 71.79, 138.58 APE8-dihe-in -59.97, 144.28 APE8-rot-in 298.9 APE67-dihe-in -65.05, -23.77 -53.99, -47.04 APE12-dist-in 13.1487 APE11-dist-in 12.2324 APE10-dist-in 7.357 APE9-dist-in 3.2609 None TPO160 TPO160 XRAY 1.95 0.211 0.251 A 301.0 298.0 0 28 28 0 [[4, 286]] 1.0 9ob4 CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4BCQA P24941 1 295 298.0 TJF:61296 Type1 Active DFGin 6.5912 15.9794 BLAminus -145.97, 170.46 62.82, 84.99 -99.38, 29.59 282.23, 71.6 -71.19, -18.61 in-in in 9.4042 Saltbr-in 3.4531 HRD-in -85.05, -58.94 78.36, 12.61 in-in-in SNCiii in-in ActLoopNT-in 3.1475 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.8, 176.97 APE9-dihe-na 69.33, 133.29 APE8-dihe-in -55.38, 139.69 APE8-rot-in 304.09 APE67-dihe-in -55.84, -22.0 -49.63, -50.65 APE12-dist-in 13.6254 APE11-dist-in 12.5429 APE10-dist-in 7.4985 APE9-dist-in 3.5108 None TPO160 TPO160 XRAY 2.4 0.217 0.252 A 301.0 290.0 5 28 28 0 [[4, 286]] 1.0 4bcq CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4BCQC P24941 1 294 298.0 TJF:61295 Type1 Active DFGin 6.5396 16.003 BLAminus -147.36, 170.23 59.21, 86.27 -98.9, 28.16 278.44, 72.82 -71.37, -12.42 in-in in 9.5981 Saltbr-in 3.2615 HRD-in -88.13, -59.99 74.18, 19.51 in-in-in SNCiii in-in ActLoopNT-in 2.9087 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.48, 157.26 APE9-dihe-na 69.58, 129.95 APE8-dihe-in -57.66, 135.49 APE8-rot-in 301.27 APE67-dihe-in -62.84, -20.05 -48.44, -46.81 APE12-dist-in 13.5398 APE11-dist-in 10.6816 APE10-dist-in 7.6895 APE9-dist-in 3.6597 None TPO160 TPO160 XRAY 2.4 0.217 0.252 C 301.0 292.0 2 28 28 0 [[4, 286]] 1.0 4bcq CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 7S9XA P24941 3 298 298.0 8KF:301 Type3 Inactive DFGin 9.1518 14.9038 BLBminus -140.51, 174.83 55.24, 52.61 -60.52, 155.06 283.44, 65.83 -96.54, 51.03 out-out out 17.0211 Saltbr-out 17.4046 HRD-in -80.98, -57.39 84.63, -18.55 out-out-out SNCooo out-out ActLoopNT-out 9.2992 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 131.76 APE9-dihe-na -82.0, 133.39 APE8-dihe-in -82.83, 123.04 APE8-rot-in 299.71 APE67-dihe-in -59.76, -23.84 -102.49, -0.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.1199 APE9-dist-out 11.0222 None None None XRAY 1.69 0.231 0.262 A 298.0 269.0 27 28 16 12 [[4, 286]] 1.0 7s9x CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2W1HA P24941 1 298 298.0 L0F:1299 Type1 Inactive DFGin 10.3073 17.775 BLBtrans -130.06, 151.5 79.56, 18.75 -69.93, 141.61 226.73, 121.67 69.65, -12.05 out-out out 14.489 Saltbr-out 16.0385 HRD-in -88.39, -56.31 79.17, -16.22 out-out-out SNCooo out-out ActLoopNT-out 5.4567 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 121.46 APE8-dihe-in -76.22, 142.93 APE8-rot-out 186.46 APE67-dihe-in -49.35, -36.85 -110.85, -4.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8052 None None None XRAY 2.15 0.263 0.308 A 298.0 283.0 15 28 17 11 [[4, 286]] 1.0 2w1h CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2R3IA P24941 1 298 298.0 SCF:60501 Type1 Inactive DFGin 10.9293 18.2404 BLBtrans -100.61, 149.54 71.45, 21.63 -58.2, 134.86 231.09, 103.4 83.18, -10.48 out-out out 15.0575 Saltbr-out 16.3446 HRD-in -91.01, -59.76 82.13, -15.3 out-out-out SNCooo out-out ActLoopNT-out 5.7069 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.45, 127.61 APE9-dihe-na -74.97, 122.45 APE8-dihe-in -60.32, 144.67 APE8-rot-out 191.76 APE67-dihe-in -59.78, -26.25 -99.25, -5.87 APE12-dist-out 20.1693 APE11-dist-out 17.5378 APE10-dist-out 18.8885 APE9-dist-out 9.9912 None None CSD177 XRAY 1.28 0.178 0.202 A 299.0 291.0 7 28 28 0 [[4, 286]] 1.0 2r3i CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 5IEXA P24941 1 298 298.0 6AF:1001 Type1 Inactive None 11.1059 18.3439 None -105.6, 149.53 71.37, 22.65 -61.85, 135.15 236.62, 103.3 74.49, -10.58 out-out out 15.1763 Saltbr-out 15.2259 HRD-in -80.72, -65.3 84.99, -26.41 out-out-out SNCooo out-out ActLoopNT-out 5.8019 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 111.81 APE8-dihe-in -112.57, 117.73 APE8-rot-in 277.98 APE67-dihe-in -67.92, -29.52 -99.02, -2.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2755 None None None XRAY 2.03 0.206 0.254 A 298.0 285.0 13 28 20 8 [[4, 286]] 1.0 5iex CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK6 CDK6_HUMAN 9PE7A Q00534 10 301 326.0 A1CIF:900 Type1 Inactive DFGin 6.8718 13.1269 BLBplus -137.4, 169.29 57.4, 61.63 -142.77, 164.35 61.09, 86.59 91.92, -16.71 out-out out 12.416 Saltbr-out 9.9299 HRD-in -63.73, -52.58 73.19, -16.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 162.46 APE9-dihe-na -100.9, 174.34 APE8-dihe-in -134.69, 96.5 APE8-rot-in 306.93 APE67-dihe-in -54.43, -27.6 -93.0, -5.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 22.3734 APE9-dist-out 12.123 E21V,K26T,T106R,Q149E None None XRAY 2.05 0.216 0.267 A 307.0 262.0 30 27 15 12 [[13, 300]] 1.0 9pe7 CMGC_CDK6_HUMAN CMGC 3.7e-84 289.5 1.0 301.0 301.0 162 163 164 166 168 43 61 65 142 144 143 145.0 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
CMGC CDK7 CDK7_HUMAN 8P71J P50613 10 310 346.0 X4F:60401 Type1 Active DFGin 6.8323 15.3042 BLAminus -139.46, 179.9 57.59, 64.02 -82.45, 17.71 282.17, 74.47 -64.72, -19.22 in-in in 8.1027 Saltbr-in 2.6939 HRD-in -67.33, -49.46 65.63, 5.51 in-in-in SNCiii in-in ActLoopNT-in 2.6395 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.68, 168.49 APE9-dihe-na 67.33, 140.05 APE8-dihe-in -60.3, 143.93 APE8-rot-in 294.53 APE67-dihe-in -61.0, -25.19 -55.87, -41.76 APE12-dist-in 13.411 APE11-dist-in 11.1922 APE10-dist-in 6.8033 APE9-dist-in 3.2758 None None None EM 2.0 999.0 999.0 J 349.0 286.0 15 28 28 0 [[12, 295]] 1.0 8p71 CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK8 CDK8_HUMAN 9H8SA P49336 1 362 464.0 A1ITF:60509 Type1 Inactive DFGin 7.3437 13.9243 BLAminus -119.28, 163.44 74.84, 82.25 -92.61, 11.91 298.93, 132.0 -87.41, 10.8 in-in in 8.6117 Saltbr-in 2.6241 HRD-in -75.25, -51.5 79.06, -6.52 in-out-out SNCioo out-out ActLoopNT-out 8.6589 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 160.05 APE8-rot-out 75.96 APE67-dihe-in -54.19, -23.95 -111.96, 19.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.157 0.197 0.248 A 414.0 335.0 27 31 14 17 [[22, 335]] 1.0 9h8s CMGC_CDK8_HUMAN CMGC 6.3e-82 281.3 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CMGC CSNK2A1 CSK21_HUMAN 8AEMA P68400 3 329 391.0 LVF:407,ATP:408 Allosteric,ATPlike Active DFGin 7.3989 16.1874 BLAminus -114.2, -178.47 56.21, 75.05 -90.39, 15.9 296.69, 81.8 -66.43, -20.83 in-in in 9.1318 Saltbr-in 2.816 HRD-in -72.91, -51.16 68.69, 11.11 in-in-in SNCiii in-in ActLoopNT-in 2.9049 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.83, 169.06 APE9-dihe-na 58.87, 157.76 APE8-dihe-in -77.1, 150.54 APE8-rot-in 294.73 APE67-dihe-in -68.78, -13.55 -40.19, -53.95 APE12-dist-in 12.7442 APE11-dist-in 10.4167 APE10-dist-in 6.256 APE9-dist-in 3.2152 R21S,K74A,K75A,K76A None None XRAY 1.6 0.19 0.212 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 8aem CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 9EPWB P68400 3 333 391.0 A1H6F:406 Type1 Active DFGin 7.3863 16.279 BLAminus -118.5, 178.76 54.91, 76.82 -86.63, 13.68 291.49, 81.55 -67.5, -20.83 out-in out 10.0457 Saltbr-in 3.2916 HRD-in -71.7, -52.07 70.7, 14.03 in-in-in SNCiii in-in ActLoopNT-in 2.8817 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.62, 167.98 APE9-dihe-na 70.49, 159.89 APE8-dihe-in -76.41, 141.74 APE8-rot-in 289.66 APE67-dihe-in -68.82, -20.3 -42.56, -42.98 APE12-dist-in 12.7948 APE11-dist-in 10.9212 APE10-dist-in 6.2791 APE9-dist-in 3.3821 None None None XRAY 2.3 0.261 0.308 B 338.0 331.0 0 27 27 0 [[39, 324]] 1.0 9epw CMGC_CSNK2A1_HUMAN CMGC 1.4e-69 240.6 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 2ZJWA P68400 1 332 391.0 REF:336 Type1 Inactive DFGin 7.3157 16.5266 BLAminus -109.16, -168.7 44.38, 76.01 -90.89, 24.26 297.46, 77.89 -76.15, -7.13 in-in in 9.4174 Saltbr-in 2.7312 HRD-in -72.0, -50.11 70.44, 13.49 in-in-out SNCiio in-out ActLoopNT-in 2.9068 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -14.58, 161.89 APE9-dihe-na 62.59, 163.98 APE8-dihe-in -84.5, 146.1 APE8-rot-out 153.88 APE67-dihe-in -63.0, -17.21 -40.84, -52.94 APE12-dist-in 12.6075 APE11-dist-in 8.9479 APE10-dist-in 5.933 APE9-dist-in 2.9919 None None None XRAY 2.4 0.222 0.274 A 340.0 332.0 0 27 27 0 [[39, 324]] 1.0 2zjw CMGC_CSNK2A1_HUMAN CMGC 1.4e-69 240.5 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7I8AA P68400 3 329 391.0 A1B0F:401 Type1 Active DFGin 7.4573 16.0714 BLAminus -110.77, 179.22 49.98, 83.2 -97.8, 27.66 295.37, 80.49 -74.55, -21.62 in-in in 8.9645 Saltbr-in 2.7479 HRD-in -69.35, -49.91 66.48, 13.83 in-in-in SNCiii in-in ActLoopNT-in 2.9297 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.27, 172.69 APE9-dihe-na 60.01, 160.49 APE8-dihe-in -88.34, 150.2 APE8-rot-in 298.89 APE67-dihe-in -68.6, -15.9 -36.65, -52.88 APE12-dist-in 12.6195 APE11-dist-in 10.1738 APE10-dist-in 6.1014 APE9-dist-in 3.048 R21S,K74A,K75A,K76A None None XRAY 1.84 0.196 0.234 A 328.0 323.0 4 27 27 0 [[39, 324]] 1.0 7i8a CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC DYRK1A DYR1A_HUMAN 6A1FA Q13627 134 483 763.0 9OF:807 Type1 Active DFGin 7.2047 15.0923 BLAminus -125.52, 173.04 69.56, 79.06 -100.37, 18.23 289.23, 81.85 -66.74, -28.25 in-in in 8.7124 Saltbr-in 2.8433 HRD-in -63.72, -44.37 75.39, -2.34 in-in-in SNCiii in-in ActLoopNT-in 2.8263 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.51, 164.33 APE9-dihe-na 78.19, 142.16 APE8-dihe-in -71.23, 146.24 APE8-rot-in 287.31 APE67-dihe-in -64.89, -24.24 -54.81, -45.1 APE12-dist-in 13.0008 APE11-dist-in 10.9373 APE10-dist-in 7.3973 APE9-dist-in 3.1888 None PTR321 PTR321 XRAY 1.5 0.178 0.195 A 360.0 346.0 4 25 25 0 [[159, 479]] 1.0 6a1f CMGC_DYRK1A_HUMAN CMGC 8.3e-91 310.2 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK2 DYRK2_HUMAN 7DH9A Q92630 215 538 601.0 H7F:601 Type1 Inactive DFGin 6.9547 15.3926 BLAminus -118.25, -176.44 52.33, 72.66 -86.4, 22.32 285.5, 71.17 -68.46, -16.6 in-in in 9.0913 Saltbr-in 2.8181 HRD-in -67.52, -48.86 77.78, -1.22 in-in-out SNCiio in-out ActLoopNT-in 2.8265 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.21, 165.64 APE9-dihe-na 77.26, 152.01 APE8-dihe-in -71.35, 136.19 APE8-rot-out 186.16 APE67-dihe-in -56.24, -27.47 -53.15, -48.91 APE12-dist-in 13.0845 APE11-dist-in 11.9349 APE10-dist-in 7.5884 APE9-dist-in 3.3083 None PTR382,SEP458 PTR382,SEP458 XRAY 2.194 0.19 0.218 A 324.0 324.0 0 25 25 0 [[222, 535]] 1.0 7dh9 CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
CMGC GSK3B GSK3B_HUMAN 9PE9A P49841 36 382 420.0 A1CIF:900 Type1 Inactive DFGin 7.0716 14.2287 BLAminus -128.7, -179.96 59.31, 84.1 -97.11, 26.91 283.64, 74.63 -73.69, -18.15 in-in in 8.351 Saltbr-in 2.7255 HRD-in -68.62, -45.57 65.7, 16.55 in-in-out SNCiio in-out ActLoopNT-in 2.9248 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -143.94, 165.33 APE9-dihe-na 76.34, 152.28 APE8-dihe-in -69.82, 130.62 APE8-rot-out 176.66 APE67-dihe-in -58.68, -26.71 -39.69, -56.4 APE12-dist-in 13.2799 APE11-dist-in 11.7578 APE10-dist-in 7.0929 APE9-dist-in 3.1547 None PTR216 PTR216 XRAY 2.11 0.221 0.247 A 359.0 332.0 13 27 27 0 [[56, 340]] 1.0 9pe9 CMGC_GSK3B_HUMAN CMGC 2e-70 243.6 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 9PE9B P49841 36 382 420.0 A1CIF:900 Type1 Inactive DFGin 7.0575 14.2183 BLAminus -128.76, -179.81 59.6, 84.42 -97.78, 27.09 283.79, 74.38 -73.25, -17.71 in-in in 8.3532 Saltbr-in 2.7132 HRD-in -68.49, -44.82 64.55, 18.32 in-in-out SNCiio in-out ActLoopNT-in 2.9402 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -144.27, 163.74 APE9-dihe-na 77.64, 152.05 APE8-dihe-in -69.14, 130.82 APE8-rot-out 177.12 APE67-dihe-in -58.92, -26.81 -39.96, -55.88 APE12-dist-in 13.3604 APE11-dist-in 11.8241 APE10-dist-in 7.1609 APE9-dist-in 3.1723 None PTR216 PTR216 XRAY 2.11 0.221 0.247 B 359.0 332.0 13 27 27 0 [[56, 340]] 1.0 9pe9 CMGC_GSK3B_HUMAN CMGC 2e-70 243.6 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 4PTEA P49841 36 382 420.0 2WF:501 Type1 Active DFGin 6.9317 14.0172 BLAminus -141.21, 178.04 57.99, 89.39 -100.23, 24.26 286.38, 75.9 -68.08, -19.02 in-in in 8.7161 Saltbr-in 2.6354 HRD-in -73.56, -44.45 69.11, 4.74 in-in-in SNCiii in-in ActLoopNT-in 2.7924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.74, 175.98 APE9-dihe-na 75.98, 148.82 APE8-dihe-in -103.79, 152.51 APE8-rot-in 295.33 APE67-dihe-inflip 95.08, -28.26 -38.95, 126.56 APE12-dist-in 12.9786 APE11-dist-in 10.8902 APE10-dist-in 5.8826 APE9-dist-in 3.0881 None None None XRAY 2.033 0.17 0.195 A 441.0 341.0 6 27 27 0 [[56, 340]] 1.0 4pte CMGC_GSK3B_HUMAN CMGC 3.7e-70 242.6 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 4PTEB P49841 36 385 420.0 2WF:501 Type1 Active DFGin 6.9181 13.9369 BLAminus -137.07, 179.43 58.52, 88.98 -101.38, 27.88 284.28, 76.88 -69.85, -20.65 in-in in 8.4836 Saltbr-in 2.6854 HRD-in -70.9, -46.61 73.05, 2.3 in-in-in SNCiii in-in ActLoopNT-in 2.8872 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -87.76, 178.59 APE9-dihe-na 72.73, 147.77 APE8-dihe-in -103.48, 150.66 APE8-rot-in 296.89 APE67-dihe-inflip 94.67, -27.57 -36.66, 125.81 APE12-dist-in 12.9354 APE11-dist-in 10.8805 APE10-dist-in 5.8765 APE9-dist-in 3.1539 None None None XRAY 2.033 0.17 0.195 B 441.0 347.0 3 27 27 0 [[56, 340]] 1.0 4pte CMGC_GSK3B_HUMAN CMGC 3.7e-70 242.6 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC MAPK1 MK01_HUMAN 5BVDA P28482 9 358 360.0 4VF:60401 Type1 None DFGin 7.0124 14.8201 BLAminus -120.88, -174.96 58.49, 83.25 -99.87, 23.43 283.53, 71.8 -56.85, -34.73 in-in in 9.2645 Saltbr-in 2.6271 HRD-in -80.64, -49.81 78.16, -6.37 in-in-none SNCiin in-none ActLoopNT-in 2.7197 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 122.19 APE8-rot-in 306.38 APE67-dihe-in -62.44, -24.22 -51.26, -49.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.172 0.207 A 361.0 330.0 20 31 15 16 [[25, 313]] 1.0 5bvd CMGC_MAPK1_HUMAN CMGC 9.2e-86 293.7 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8AO6A P28482 11 356 360.0 N9F:406 Type1 Inactive DFGin 6.7709 16.337 BLAminus -129.81, 177.88 71.62, 78.81 -103.22, 23.44 283.23, 73.97 -64.0, -29.38 out-in out 10.3714 Saltbr-in 2.597 HRD-in -72.45, -50.74 72.14, 4.83 in-in-out SNCiio in-out ActLoopNT-in 2.7853 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -96.92, -36.24 APE9-dihe-na -66.98, 156.39 APE8-dihe-in -51.35, 125.27 APE8-rot-in 311.93 APE67-dihe-in -64.42, -17.18 -56.32, -47.54 APE12-dist-out 14.4141 APE11-dist-in 11.1069 APE10-dist-in 7.1029 APE9-dist-in 4.2638 None None CME127,CME161 XRAY 1.811 0.175 0.222 A 368.0 338.0 0 31 31 0 [[25, 313]] 1.0 8ao6 CMGC_MAPK1_HUMAN CMGC 9.9e-86 293.6 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8AO9A P28482 11 356 360.0 N4F:406 Type1 Inactive DFGin 6.837 16.4502 BLAminus -129.5, 178.83 61.88, 81.37 -96.97, 21.21 286.14, 78.83 -59.7, -30.7 out-out out 10.3006 Saltbr-out 3.7652 HRD-in -72.95, -49.65 72.84, 3.98 out-in-out SNCoio in-out ActLoopNT-in 2.8539 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -91.06, -44.4 APE9-dihe-na -60.28, 156.59 APE8-dihe-in -55.09, 130.24 APE8-rot-in 307.62 APE67-dihe-in -64.58, -17.09 -62.44, -44.52 APE12-dist-out 14.2701 APE11-dist-in 10.9807 APE10-dist-in 6.7892 APE9-dist-in 4.2298 None None CME161 XRAY 1.624 0.184 0.232 A 368.0 338.0 2 31 31 0 [[25, 313]] 1.0 8ao9 CMGC_MAPK1_HUMAN CMGC 9.9e-86 293.6 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK10 MK10_HUMAN 3CGFA P53779 45 400 464.0 JNF:523 Type1 Inactive DFGin 3.7194 14.0388 ABAminus -89.59, -53.32 -106.99, -179.49 -117.03, 20.53 309.75, 79.33 76.52, -162.79 in-out in 9.6016 Saltbr-out 3.6113 HRD-in -43.19, -70.09 72.17, 4.64 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -63.93, 178.32 APE9-dihe-na -126.54, 145.54 APE8-dihe-in -86.07, 133.09 APE8-rot-in 307.62 APE67-dihe-in -51.07, -34.7 -123.34, -6.64 APE12-dist-out 21.3349 APE11-dist-out 17.8933 APE10-dist-out 16.6152 APE9-dist-out 11.4736 None None None XRAY 3.0 0.225 0.317 A 365.0 346.0 5 27 22 5 [[64, 359]] 1.0 3cgf CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1.0 301.0 301.0 206 207 208 210 212 93 111 115 186 188 187 189.0 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 7YL1A P53779 45 400 464.0 J6F:501 Type1 Inactive DFGin 3.9949 14.0597 ABAminus -80.16, -27.18 -141.36, 174.64 -114.52, 17.98 302.24, 85.17 76.51, -161.32 in-in in 9.2297 Saltbr-in 2.7546 HRD-in -85.09, -59.15 76.16, -2.31 in-out-out SNCioo out-out ActLoopNT-out 6.4415 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -89.31, 134.84 APE9-dihe-na -84.54, 138.55 APE8-dihe-in -77.28, 127.44 APE8-rot-in 291.87 APE67-dihe-in -54.76, -19.99 -106.7, -13.11 APE12-dist-out 20.7213 APE11-dist-out 15.8773 APE10-dist-out 16.1956 APE9-dist-out 11.2727 None None None XRAY 2.48 0.208 0.294 A 464.0 352.0 2 27 25 2 [[64, 359]] 1.0 7yl1 CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1.0 301.0 301.0 206 207 208 210 212 93 111 115 186 188 187 189.0 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK14 MK14_HUMAN 6ZQSA Q16539 4 353 360.0 3FF:400 Type1 Inactive DFGin 7.1312 15.0067 BLAminus -100.05, 172.92 58.72, 89.64 -100.69, 26.63 286.71, 76.86 -66.14, -26.38 out-out out 10.2824 Saltbr-out 3.9201 HRD-in -83.97, -53.39 74.81, 10.18 out-in-in SNCoii in-in ActLoopNT-in 2.8547 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.23, 173.02 APE9-dihe-na 73.87, 161.94 APE8-dihe-in -91.46, 139.33 APE8-rot-in 294.96 APE67-dihe-in -66.05, -18.45 -53.95, -45.87 APE12-dist-in 11.599 APE11-dist-in 11.174 APE10-dist-in 6.7713 APE9-dist-in 3.0458 None TPO180,PTR182 TPO180,PTR182 XRAY 1.95 0.178 0.223 A 362.0 350.0 0 25 25 0 [[24, 308]] 1.0 6zqs CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 5XYYA Q16539 4 352 360.0 P0F:401 Type1.5_Back Inactive DFGin 8.1438 16.2502 BLBminus -111.25, 174.05 61.59, 81.71 -109.03, 145.8 286.82, 89.51 69.26, 21.62 in-in in 8.942 Saltbr-in 2.6487 HRD-in -68.14, -52.86 82.9, -10.64 in-out-out SNCioo out-out ActLoopNT-out 11.4762 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.86, 131.59 APE9-dihe-na -62.4, -17.36 APE8-dihe-out -62.41, -19.09 APE8-rot-out 53.75 APE67-dihe-in -64.55, -20.22 -114.48, -18.89 APE12-dist-out 21.1385 APE11-dist-out 22.895 APE10-dist-out 17.0927 APE9-dist-out 11.7589 None None None XRAY 1.7 0.18 0.201 A 380.0 343.0 6 25 25 0 [[24, 308]] 1.0 5xyy CMGC_MAPK14_HUMAN CMGC 7e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 2QD9A Q16539 5 352 360.0 LGF:361 Type1 Inactive DFGin 5.1343 13.7971 BLBplus -108.86, 148.96 74.79, 24.8 -73.05, 150.79 49.54, 82.76 82.07, 6.15 in-in in 9.155 Saltbr-in 2.5566 HRD-in -76.06, -55.95 78.8, -20.76 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -59.56, -22.52 999.0, -59.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.252 0.282 A 366.0 330.0 18 25 12 13 [[24, 308]] 1.0 2qd9 CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3QUDA Q16539 4 354 360.0 N3F:361 Type1 Inactive DFGin 10.8012 12.5528 None -93.66, 153.34 -68.51, -47.3 -136.82, 128.38 301.98, 103.1 -95.02, -166.54 in-in in 9.269 Saltbr-in 3.5549 HRD-in -63.42, -58.28 80.41, -12.58 in-out-out SNCioo out-out ActLoopNT-out 20.8014 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 112.75 APE9-dihe-na -76.37, 136.79 APE8-dihe-out -65.47, -38.0 APE8-rot-in 295.71 APE67-dihe-in -57.05, -26.46 -56.48, -28.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.7622 APE9-dist-out 12.6517 None None None XRAY 2.0 0.234 0.278 A 360.0 345.0 6 25 19 6 [[24, 308]] 1.0 3qud CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3QUEA Q16539 5 353 360.0 3FF:362 Type1 Inactive DFGin 10.6415 12.3386 None -82.41, 155.86 -75.27, -54.23 -130.98, 134.23 308.77, 88.25 -97.08, -170.31 in-in in 8.9604 Saltbr-in 2.6567 HRD-in -64.83, -54.13 86.66, -27.06 in-out-out SNCioo out-out ActLoopNT-out 21.2792 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 66.84 APE9-dihe-na -77.78, 135.56 APE8-dihe-out -48.89, -54.16 APE8-rot-in 280.74 APE67-dihe-in -53.38, -25.8 -51.95, -34.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.1952 APE9-dist-out 11.3927 None None None XRAY 2.7 0.23 0.311 A 360.0 343.0 6 25 19 6 [[24, 308]] 1.0 3que CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4R3CA Q16539 4 352 360.0 3GF:402,3GF:403 Type1,Allosteric Inactive DFGin 4.9243 13.1341 None -118.67, 171.2 49.4, 42.48 -86.86, 999.0 38.51, 75.43 999.0, 999.0 in-out in 9.5432 Saltbr-out 3.9084 HRD-in -66.01, -56.32 81.1, -14.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 103.85 APE9-dihe-na -65.1, 130.86 APE8-dihe-out -51.86, -39.46 APE8-rot-in 289.55 APE67-dihe-in -62.53, -25.36 -48.44, -37.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2638 None None CME162 XRAY 2.06 0.178 0.217 A 383.0 336.0 13 25 12 13 [[24, 308]] 1.0 4r3c CMGC_MAPK14_HUMAN CMGC 7.2e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3L8SA Q16539 4 353 360.0 BFF:361 Type1 Inactive DFGout 15.4888 11.9771 None -119.54, 162.4 -99.13, -16.66 31.92, 999.0 247.73, 144.9 999.0, 999.0 in-in in 9.4966 Saltbr-in 2.8175 HRD-in -77.51, -50.13 90.87, -25.05 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 107.11 APE9-dihe-na -94.83, 118.78 APE8-dihe-out -62.16, -3.07 APE8-rot-out 173.18 APE67-dihe-in -59.13, -22.21 -95.45, -15.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.2005 C119S,C162S,A172C,F327L None None XRAY 2.35 0.242 0.307 A 360.0 334.0 16 25 12 13 [[24, 308]] 1.0 3l8s CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3UVRA Q16539 5 351 360.0 06F:361 Type2 Inactive DFGout 15.5607 8.5245 None -148.63, 178.6 -133.58, 101.18 -90.01, -1.78 195.55, 17.77 -54.07, 127.45 in-in in 8.2112 Saltbr-in 2.6266 HRD-in -62.71, -55.49 83.79, -17.62 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -56.89 APE8-dihe-out -51.15, -30.26 APE8-rot-in 300.71 APE67-dihe-in -70.54, -25.21 -93.95, -15.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.6213 None None None XRAY 2.1 0.204 0.245 A 360.0 331.0 16 25 13 12 [[24, 308]] 1.0 3uvr CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK8 MK08_HUMAN 8PTAA P45983 8 363 427.0 CIF:401 Type1 Inactive DFGin 3.923 14.4771 ABAminus -80.58, -61.37 -103.85, 165.38 -100.79, 23.99 295.77, 91.74 73.84, -149.47 in-in in 9.7897 Saltbr-in 3.1262 HRD-in -78.59, -61.53 62.23, 7.12 in-out-out SNCioo out-out ActLoopNT-out 6.4702 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -130.45, 138.38 APE9-dihe-na -101.99, 109.25 APE8-dihe-in -118.89, 112.23 APE8-rot-out 53.5 APE67-dihe-in -51.79, -30.07 -95.29, -17.54 APE12-dist-in 10.569 APE11-dist-out 7.0333 APE10-dist-out 10.1833 APE9-dist-out 8.5978 None None None XRAY 2.41 0.224 0.226 A 366.0 354.0 2 27 25 2 [[26, 321]] 1.0 8pta CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 8PTAB P45983 7 363 427.0 CIF:401 Type1 Inactive DFGin 3.5773 13.1788 ABAminus -81.24, -57.35 -101.3, 158.61 -105.36, 14.2 308.93, 93.28 64.59, -148.13 in-in in 9.3658 Saltbr-in 3.5356 HRD-in -77.41, -61.25 61.49, 9.23 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -112.33, 168.25 APE9-dihe-na -116.9, 36.67 APE8-dihe-in -104.63, 91.0 APE8-rot-out 52.55 APE67-dihe-in -56.88, -29.41 -95.02, -21.65 APE12-dist-in 11.7839 APE11-dist-in 9.1521 APE10-dist-out 11.2421 APE9-dist-out 10.2145 None None None XRAY 2.41 0.224 0.226 B 366.0 352.0 5 27 22 5 [[26, 321]] 1.0 8pta CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 8PTAC P45983 8 361 427.0 CIF:401 Type1 Inactive DFGin 3.8263 14.0885 ABAminus -83.97, -56.35 -97.04, 154.46 -105.76, 13.83 294.99, 32.04 63.79, -147.27 in-out in 9.7228 Saltbr-out 4.5276 HRD-in -77.01, -60.9 63.25, 7.56 out-out-out SNCooo out-out ActLoopNT-out 4.6109 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -137.59 APE9-dihe-na -94.11, 17.64 APE8-dihe-in -81.48, 63.35 APE8-rot-out 71.39 APE67-dihe-in -58.68, -26.77 -108.19, -24.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.4666 APE9-dist-out 10.7804 None None None XRAY 2.41 0.224 0.226 C 366.0 351.0 3 27 24 3 [[26, 321]] 1.0 8pta CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK9 MK09_HUMAN 3E7OA P45984 9 361 424.0 35F:1 Type1 Inactive DFGin 4.2658 14.5259 ABAminus -84.35, -29.35 -149.55, 177.24 -106.27, 9.79 301.22, 95.14 60.95, -143.01 in-in in 9.4394 Saltbr-in 2.6864 HRD-in -64.97, -51.12 67.58, -6.1 in-out-out SNCioo out-out ActLoopNT-out 5.5191 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -84.71, -45.82 APE9-dihe-na -76.84, -178.43 APE8-dihe-in -88.6, 137.99 APE8-rot-in 266.04 APE67-dihe-out -72.72, -13.34 -138.1, 64.96 APE12-dist-out 20.2903 APE11-dist-out 15.6856 APE10-dist-out 19.3278 APE9-dist-out 14.6648 C177S,C222S,K250A,K251A,K265A,K270A None None XRAY 2.14 0.219 0.25 A 360.0 342.0 2 27 27 0 [[26, 321]] 1.0 3e7o CMGC_MAPK9_HUMAN CMGC 2.7e-84 288.8 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 9
CMGC MAPK9 MK09_HUMAN 3E7OB P45984 8 362 424.0 35F:2 Type1 Inactive DFGin 4.2756 14.3183 ABAminus -85.32, -37.61 -133.45, 175.33 -107.39, 15.94 299.45, 88.14 90.36, 999.0 in-in in 9.4665 Saltbr-in 2.8008 HRD-in -71.07, -57.75 72.11, -12.31 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -39.52 APE8-rot-out 181.64 APE67-dihe-in -65.99, -17.44 -49.19, -35.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C177S,C222S,K250A,K251A,K265A,K270A None None XRAY 2.14 0.219 0.25 B 360.0 326.0 19 27 11 16 [[26, 321]] 1.0 3e7o CMGC_MAPK9_HUMAN CMGC 2.7e-84 288.8 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 9
OTHER CDC7 CDC7_HUMAN 6YA8A O00311 38 572 574.0 ADP:60601,BEF:60603 ATPlike,Allosteric None DFGin 6.1681 14.0868 BLAminus -118.93, 173.08 76.34, 83.66 -102.33, 21.87 291.62, 81.2 -67.07, -22.7 in-in in 8.7089 Saltbr-in 2.7382 HRD-in -65.76, -44.2 72.35, -4.4 in-in-none SNCiin in-none ActLoopNT-in 2.755 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na -83.06, -154.71 APE8-dihe-in -48.63, 132.1 APE8-rot-in 306.86 APE67-dihe-in -66.07, -7.37 -59.08, -35.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.8876 None None None XRAY 1.79 0.167 0.197 A 359.0 338.0 13 188 175 13 [[58, 569]] 1.0 6ya8 OTHER_CDC7_HUMAN CMGC 2e-18 137.3 1.0 161.0 296.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 375 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER GAK GAK_HUMAN 4C57A O14976 25 334 1311.0 FEF:1340 Type1 Inactive DFGin 5.7541 14.1406 ABAminus -112.53, -37.31 -102.07, 134.52 -132.21, 22.67 297.88, 98.14 -59.75, -31.11 in-out in 9.9935 Saltbr-out 4.0566 HRD-in -62.14, -51.36 70.7, -5.09 out-in-in SNCoii in-in ActLoopNT-in 2.8949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.34, 3.52 APE9-dihe-na -124.99, 156.99 APE8-dihe-in -84.98, 122.71 APE8-rot-in 297.75 APE67-dihe-in -71.57, -19.62 -46.23, -44.89 APE12-dist-in 11.7793 APE11-dist-in 8.5735 APE10-dist-in 4.3301 APE9-dist-in 4.0704 None None None XRAY 2.55 0.18 0.228 A 340.0 310.0 0 40 40 0 [[40, 313]] 1.0 4c57 OTHER_GAK_HUMAN CAMK 5.3e-44 156.7 3.0 252.0 250.0 190 191 192 194 196 69 85 89 170 172 171 173.0 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 4C57B O14976 27 334 1311.0 FEF:1337 Type1 Inactive DFGin 5.7695 14.2334 ABAminus -105.07, -37.59 -101.51, 133.86 -130.57, 22.88 297.9, 97.48 -60.27, -26.81 out-out out 10.0646 Saltbr-out 4.0563 HRD-in -62.14, -52.49 71.3, -9.85 out-in-in SNCoii in-in ActLoopNT-in 2.8914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.07, 5.67 APE9-dihe-na -124.2, 156.66 APE8-dihe-in -83.72, 121.96 APE8-rot-in 296.0 APE67-dihe-in -71.56, -19.42 -45.7, -45.17 APE12-dist-in 11.9284 APE11-dist-in 8.6579 APE10-dist-in 4.358 APE9-dist-in 4.0859 None None None XRAY 2.55 0.18 0.228 B 340.0 308.0 0 40 40 0 [[40, 313]] 1.0 4c57 OTHER_GAK_HUMAN CAMK 5.3e-44 156.7 3.0 252.0 250.0 190 191 192 194 196 69 85 89 170 172 171 173.0 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 4C59A O14976 27 333 1311.0 FEF:1334 Type1 Inactive DFGin 5.8147 13.6797 ABAminus -134.62, -10.32 -105.18, 88.43 -107.04, 23.92 300.54, 105.0 -81.95, -10.0 in-in in 9.0927 Saltbr-in 2.8554 HRD-in -82.36, -54.36 82.63, -15.13 in-in-none SNCiin in-none ActLoopNT-in 2.8383 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.205 0.262 A 340.0 266.0 41 40 13 27 [[40, 313]] 1.0 4c59 OTHER_GAK_HUMAN CAMK 5.3e-44 156.7 3.0 252.0 250.0 190 191 192 194 196 69 85 89 170 172 171 173.0 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER HASPIN HASP_HUMAN 9FLTA Q8TF76 471 798 798.0 A1IDF:801 Type1 Active DFGin 5.1776 12.2183 BLAminus -141.02, 178.95 59.99, 70.73 -81.95, 27.03 316.78, 141.24 -69.29, -28.67 in-in in 8.7595 Saltbr-in 2.4634 HRD-naN -66.6, -53.16 75.71, 6.9 in-in-na SNCiia in-na ActLoopNT-in 2.9046 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -131.58, 41.34 APE9-dihe-na -102.69, 164.5 APE8-dihe-na -162.68, -171.46 APE8-rot-na 41.52 APE67-dihe-na -134.91, 146.64 100.36, -24.97 APE12-dist-na 9.6398 APE11-dist-na 13.5093 APE10-dist-na 17.2466 APE9-dist-na 13.2789 None None None XRAY 2.4 0.187 0.239 A 336.0 320.0 8 35 35 0 [[484, 797]] 1.0 9flt OTHER_HASPIN_HUMAN HASP 1.1e-226 756.9 1.0 314.0 314.0 686 687 688 690 692 511 535 539 646 648 647 649.0 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER TTK TTK_HUMAN 4JS8A P33981 515 793 857.0 1PF:801 Type1 Inactive DFGin 4.2459 15.0178 ABAminus -84.57, -49.34 -133.98, 167.4 -109.17, 14.51 305.07, 151.28 67.69, 15.63 in-out in 9.9926 Saltbr-out 6.6989 HRD-in -62.96, -52.34 70.46, -10.5 out-out-out SNCooo out-out ActLoopNT-out 12.0357 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnoo APE10-dihe-na 999.0, 112.01 APE9-dihe-na -104.69, -175.56 APE8-dihe-in -119.7, 153.55 APE8-rot-none 999.0 APE67-dihe-in -65.36, -29.34 -115.57, 0.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.1985 APE9-dist-out 12.1114 None TPO675,TPO686 TPO675,TPO686 XRAY 1.94 0.232 0.253 A 281.0 261.0 18 30 22 8 [[525, 791]] 1.0 4js8 OTHER_TTK_HUMAN CAMK 5.6e-54 189.1 1.0 256.0 256.0 663 664 665 667 669 553 571 575 644 646 645 647.0 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 7CHMA P33981 516 794 857.0 FZF:801 Type1 Inactive DFGin 4.4135 14.6083 None -111.88, -71.82 -63.89, 158.67 -119.5, 9.1 283.45, 179.72 82.92, -15.75 in-in in 9.5598 Saltbr-in 3.396 HRD-in -57.59, -51.23 60.31, 6.24 in-out-out SNCioo out-out ActLoopNT-out 12.2637 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, -62.47 APE9-dihe-na 66.11, 172.68 APE8-dihe-out -121.28, -175.85 APE8-rot-none 999.0 APE67-dihe-in -54.56, -33.62 -132.81, 0.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.8631 APE9-dist-out 12.904 None TPO675,TPO686 TPO675,TPO686 XRAY 2.65 0.212 0.253 A 281.0 260.0 19 30 22 8 [[525, 791]] 1.0 7chm OTHER_TTK_HUMAN CAMK 5.6e-54 189.1 1.0 256.0 256.0 663 664 665 667 669 553 571 575 644 646 645 647.0 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER ULK1 ULK1_HUMAN 4WNOA O75385 8 280 1050.0 3RF:401 Type1 Active DFGin 6.8894 14.9489 BLAminus -117.94, 169.26 64.81, 74.6 -94.14, 20.86 282.18, 71.59 -63.55, -24.11 in-in in 7.6619 Saltbr-in 2.7703 HRD-in -82.57, -51.36 80.06, -2.07 in-in-in SNCiii in-in ActLoopNT-in 2.9659 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.03, 162.62 APE9-dihe-na 120.91, -162.5 APE8-dihe-in -119.54, 124.2 APE8-rot-in 305.96 APE67-dihe-in -67.71, -19.19 -53.63, -37.75 APE12-dist-in 8.2136 APE11-dist-in 11.2124 APE10-dist-in 5.6751 APE9-dist-in 3.309 E37A,K38A TPO180 TPO180 XRAY 1.56 0.18 0.208 A 287.0 273.0 0 27 27 0 [[14, 278]] 1.0 4wno OTHER_ULK1_HUMAN ULK 2.1e-132 446.2 1.0 256.0 256.0 164 165 166 168 170 46 63 67 135 137 136 138.0 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
STE MAP2K1 MP2K1_HUMAN 7UMBC Q02750 41 381 393.0 ANP:401,U9F:402 ATPlike,Type3 Inactive DFGin 6.169 13.7668 BLBplus -162.24, 171.11 70.21, 49.7 -113.95, 160.88 44.65, 94.08 -79.06, 81.13 out-out out 15.5589 Saltbr-out 15.2725 HRD-in -66.12, -48.09 76.83, -9.86 out-out-out SNCooo out-out ActLoopNT-out 9.5911 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -127.94, 139.36 APE9-dihe-na -138.86, -160.81 APE8-dihe-out -82.2, -18.64 APE8-rot-out 50.9 APE67-dihe-out -106.39, 139.13 -104.8, 110.61 APE12-dist-out 16.6992 APE11-dist-out 19.6656 APE10-dist-out 21.5701 APE9-dist-out 14.915 None None None XRAY 3.231 0.231 0.268 C 384.0 303.0 38 26 26 0 [[68, 361]] 1.0 7umb STE_MAP2K1_HUMAN STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K7 MP2K7_HUMAN 6YG3A O14733 103 400 419.0 6HF:60510 Type1 None DFGin 6.1952 14.5493 BLAminus -146.55, 178.23 54.3, 83.97 -103.73, 30.03 316.89, 91.95 -57.17, -29.89 in-na in 8.3452 Saltbr-na 3.3604 HRD-in -81.36, -52.29 76.4, 12.98 na-in-none SNCain in-none ActLoopNT-in 2.9822 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.05 0.191 0.235 A 307.0 265.0 33 27 8 19 [[120, 380]] 1.0 6yg3 STE_MAP2K7_HUMAN STE 2.4e-80 275.5 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
STE MAP4K1 M4K1_HUMAN 8FH4A Q92918 4 293 833.0 XXF:60401 Type1 Inactive DFGin 6.8462 14.4745 BLAminus -131.99, 171.23 62.34, 86.7 -92.12, 20.1 289.3, 88.42 -59.7, -48.05 in-in in 9.2322 Saltbr-in 2.734 HRD-in -67.47, -51.18 67.4, 4.94 in-out-out SNCioo out-out ActLoopNT-out 6.1988 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -73.65, -44.57 APE9-dihe-na 76.29, -171.23 APE8-dihe-in -62.48, 141.12 APE8-rot-out 34.25 APE67-dihe-in -59.58, -27.68 -102.29, 0.49 APE12-dist-out 20.3044 APE11-dist-out 21.0787 APE10-dist-out 21.4211 APE9-dist-out 27.2591 T165E,S171E None None XRAY 1.827 0.189 0.215 A 331.0 290.0 0 28 28 0 [[17, 274]] 1.0 8fh4 STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FH4B Q92918 6 302 833.0 XXF:60402 Type1 Inactive DFGin 6.5509 14.2937 BLAminus -141.43, 174.43 62.64, 85.33 -93.2, 13.55 285.99, 85.49 -57.34, -45.75 in-in in 8.9388 Saltbr-in 2.6969 HRD-in -67.85, -50.88 67.73, 2.48 in-out-out SNCioo out-out ActLoopNT-out 6.3091 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -67.39, -32.57 APE9-dihe-na 75.42, -167.37 APE8-dihe-in -61.44, 126.8 APE8-rot-out 59.49 APE67-dihe-in -56.24, -30.95 -97.05, -0.91 APE12-dist-out 19.4642 APE11-dist-out 20.5862 APE10-dist-out 21.6649 APE9-dist-out 28.0466 T165E,S171E None None XRAY 1.827 0.189 0.215 B 331.0 297.0 0 28 28 0 [[17, 274]] 1.0 8fh4 STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FH4C Q92918 1 292 833.0 XXF:60401 Type1 Inactive DFGin 6.8242 14.1178 BLAminus -136.31, 172.65 64.01, 85.1 -95.02, 19.77 288.84, 83.7 -61.21, -46.39 in-in in 8.9671 Saltbr-in 2.7326 HRD-in -69.91, -50.19 67.9, 0.86 in-out-out SNCioo out-out ActLoopNT-out 6.0797 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -67.7, -68.85 APE9-dihe-na -109.26, -27.15 APE8-dihe-in -115.11, 101.44 APE8-rot-out 62.11 APE67-dihe-in -65.51, -20.35 -96.81, 16.0 APE12-dist-out 19.3179 APE11-dist-out 20.9352 APE10-dist-out 23.0855 APE9-dist-out 28.3652 T165E,S171E None None XRAY 1.827 0.189 0.215 C 331.0 292.0 0 28 28 0 [[17, 274]] 1.0 8fh4 STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FH4D Q92918 8 292 833.0 XXF:60401 Type1 Inactive DFGin 6.6457 14.0225 BLAminus -135.73, 170.9 66.66, 83.46 -93.58, 25.1 289.61, 94.72 -69.05, -41.66 in-in in 9.0222 Saltbr-in 2.7448 HRD-in -74.6, -51.27 71.89, -5.96 in-out-out SNCioo out-out ActLoopNT-out 6.1341 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -170.02 APE8-dihe-in -67.05, 131.5 APE8-rot-out 192.16 APE67-dihe-in -57.98, -30.82 -102.78, -3.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 27.4265 T165E,S171E None None XRAY 1.827 0.189 0.215 D 331.0 276.0 9 28 24 4 [[17, 274]] 1.0 8fh4 STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9QT6A Q92918 6 292 833.0 A1JAF:301 Type1 Inactive DFGin 6.4629 13.7652 None -60.93, -35.58 -154.04, -176.9 -79.86, 1.42 63.88, 19.01 105.02, -157.57 out-out out 13.2797 Saltbr-out 10.7822 HRD-in -74.09, -55.53 70.27, 5.38 out-out-out SNCooo out-out ActLoopNT-out 7.5816 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -59.89, -40.77 APE9-dihe-na -92.18, -16.28 APE8-dihe-in -142.86, 74.69 APE8-rot-in 316.27 APE67-dihe-in -56.11, -27.62 -91.41, -1.8 APE12-dist-in 9.8088 APE11-dist-in 11.1344 APE10-dist-out 15.1534 APE9-dist-out 12.6983 T165E,S171E None None XRAY 1.76 0.198 0.226 A 294.0 285.0 2 28 28 0 [[17, 274]] 1.0 9qt6 STE_MAP4K1_HUMAN STE 4.1e-92 314.1 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8CIJA Q92918 14 294 833.0 USF:401 Type1 Inactive DFGout 11.2132 7.331 None -112.58, 122.54 -96.1, 115.56 -121.01, 999.0 297.98, 106.95 999.0, 999.0 out-out out 13.5351 Saltbr-out 11.7998 HRD-in -61.67, -48.53 69.18, 2.25 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na -87.98, 122.06 APE9-dihe-na 145.78, 142.84 APE8-dihe-in -120.8, 116.13 APE8-rot-in 320.07 APE67-dihe-in -58.16, -27.75 -31.5, -57.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.6814 None None None XRAY 2.821 0.239 0.266 A 307.0 264.0 17 28 16 12 [[17, 274]] 1.0 8cij STE_MAP4K1_HUMAN STE 4.8e-92 313.9 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K4 M4K4_HUMAN 5DI1A O95819 13 309 1239.0 5DF:4000 Type1 Inactive DFGin 4.2602 13.3659 BLBplus -145.12, 159.02 72.53, 52.2 -89.55, 138.32 48.51, 95.38 -80.62, 999.0 in-out in 9.4027 Saltbr-out 3.985 HRD-in -61.2, -47.09 79.65, -23.06 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -102.21, 124.07 APE9-dihe-na -81.57, -147.04 APE8-dihe-in -74.95, 131.45 APE8-rot-out 195.98 APE67-dihe-in -46.35, -33.38 -85.44, -21.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.6024 None None None XRAY 2.9 0.2 0.249 A 310.0 285.0 12 28 16 12 [[25, 289]] 1.0 5di1 STE_MAP4K4_HUMAN STE 1.3e-102 348.4 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
TKL ACVR1 ACVR1_HUMAN 3MTFA Q04771 203 498 509.0 A3F:1 Type1 Inactive DFGin 7.0905 13.2083 BLAminus -126.1, 157.67 76.9, 82.69 -86.05, 21.36 306.23, 175.03 -61.66, -24.97 in-out in 8.3313 Saltbr-out 4.1956 HRD-in -82.54, -58.57 79.29, -1.49 out-in-out SNCoio in-out ActLoopNT-in 2.9128 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -103.22, 162.67 APE9-dihe-na -69.88, 165.81 APE8-dihe-in -53.93, 121.99 APE8-rot-in 312.82 APE67-dihe-in -59.42, -28.32 -57.34, -37.41 APE12-dist-in 10.6706 APE11-dist-out 6.476 APE10-dist-out 9.4819 APE9-dist-in 4.0726 Q207D None None XRAY 2.15 0.185 0.244 A 301.0 296.0 0 32 32 0 [[207, 497]] 1.0 3mtf TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 3MTFB Q04771 202 499 509.0 A3F:501 Type1 Inactive DFGin 7.5781 13.3226 BLAminus -114.45, 160.06 82.35, 87.49 -104.83, 25.86 291.12, 164.81 -75.29, -13.54 in-out in 8.5 Saltbr-out 4.2324 HRD-in -82.5, -60.12 85.3, -4.39 out-in-out SNCoio in-out ActLoopNT-in 2.869 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -111.75, 153.3 APE9-dihe-na -57.45, 170.81 APE8-dihe-in -65.39, 131.64 APE8-rot-in 306.28 APE67-dihe-in -49.77, -35.33 -68.1, -43.23 APE12-dist-in 10.6109 APE11-dist-out 6.4527 APE10-dist-out 9.3963 APE9-dist-in 4.1192 Q207D None None XRAY 2.15 0.185 0.244 B 301.0 298.0 0 32 32 0 [[207, 497]] 1.0 3mtf TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 6EIXA Q04771 192 503 509.0 A3F:601 Type1 Inactive DFGin 7.3048 13.3822 BLAminus -122.31, 163.89 74.01, 85.68 -98.53, 23.31 310.02, 174.96 -66.89, -23.04 in-out in 9.0828 Saltbr-out 5.1598 HRD-in -81.6, -53.66 78.97, -2.54 out-in-out SNCoio in-out ActLoopNT-in 3.0232 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -113.45, 165.41 APE9-dihe-na -59.94, 163.8 APE8-dihe-in -59.76, 126.51 APE8-rot-in 307.55 APE67-dihe-in -58.05, -30.26 -58.58, -41.78 APE12-dist-in 10.589 APE11-dist-out 6.415 APE10-dist-out 9.3108 APE9-dist-in 3.8713 Q207E None None XRAY 2.3 0.191 0.249 A 340.0 312.0 0 32 32 0 [[207, 497]] 1.0 6eix TKL_ACVR1_HUMAN TKL 2.9e-85 292.0 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 8PODA Q04771 172 498 509.0 7IO:60501,F:60502 Type1,Allosteric Inactive DFGin 7.1808 13.2482 BLAminus -129.23, 172.96 64.95, 88.23 -102.11, 21.22 307.17, 178.99 -69.46, -24.05 in-out in 8.7504 Saltbr-out 5.2405 HRD-in -77.46, -49.01 73.0, -1.63 out-in-out SNCoio in-out ActLoopNT-in 3.1049 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -104.74, 151.99 APE9-dihe-na -69.89, 170.49 APE8-dihe-in -67.7, 124.46 APE8-rot-in 304.29 APE67-dihe-in -63.94, -28.35 -69.6, -32.91 APE12-dist-in 10.7398 APE11-dist-out 6.5417 APE10-dist-out 9.7318 APE9-dist-in 4.6474 None None None XRAY 2.59 0.236 0.255 A 330.0 320.0 1 32 32 0 [[207, 497]] 1.0 8pod TKL_ACVR1_HUMAN TKL 2.6e-85 292.1 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL BRAF BRAF_HUMAN 4YHTA P15056 449 719 766.0 4EF:61002 Type1 Inactive DFGin 6.4399 13.919 BLAminus -130.91, -175.71 59.89, 88.64 -101.88, 16.92 281.61, 73.69 -54.19, -26.07 in-in in 8.6082 Saltbr-in 2.7306 HRD-in -63.73, -42.35 62.62, 3.64 in-in-out SNCiio in-out ActLoopNT-in 2.8806 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -6.83 APE8-dihe-in -100.18, 82.06 APE8-rot-in 287.27 APE67-dihe-in -63.55, -16.06 -74.16, -21.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.1095 I543T,I544N,I551T,L706T,L716T None None XRAY 3.05 0.2 0.233 A 272.0 256.0 15 30 17 13 [[457, 716]] 1.0 4yht TKL_BRAF_HUMAN TKL 2.7e-84 288.8 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 4YHTB P15056 449 720 766.0 4EF:60802 Type1 Inactive DFGin 6.4052 13.9205 BLAminus -128.69, -172.56 54.11, 90.89 -102.92, 13.66 281.86, 71.12 -49.43, -28.96 in-in in 8.5831 Saltbr-in 2.7006 HRD-in -63.82, -42.99 62.91, 4.22 in-in-out SNCiio in-out ActLoopNT-in 2.8638 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -6.59 APE8-dihe-in -97.87, 80.96 APE8-rot-in 285.28 APE67-dihe-in -62.85, -18.47 -75.71, -20.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.0341 I543T,I544N,I551T,L706T,L716T None None XRAY 3.05 0.2 0.233 B 272.0 258.0 14 30 18 12 [[457, 716]] 1.0 4yht TKL_BRAF_HUMAN TKL 2.7e-84 288.8 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 3Q96A P15056 449 722 766.0 0NF:1 Type2 Inactive DFGout 12.8873 10.6757 BBAminus -160.13, -172.44 -118.2, 91.86 -79.01, 12.35 294.04, 84.62 -59.8, 141.31 in-in in 8.3917 Saltbr-in 2.8554 HRD-in -57.31, -47.78 82.12, -11.82 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -115.71 APE8-rot-in 265.02 APE67-dihe-in -61.58, -24.04 -87.09, -36.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.1 0.233 0.288 A 282.0 253.0 21 30 12 18 [[457, 716]] 1.0 3q96 TKL_BRAF_HUMAN TKL 8e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 3Q96B P15056 449 720 766.0 0NF:1 Type2 Inactive DFGout 12.3376 11.6545 BBAminus -159.06, -168.23 -117.43, 81.54 -79.68, 17.57 296.0, 82.29 -26.83, 105.54 in-in in 8.5859 Saltbr-in 3.1759 HRD-in -76.92, -42.58 73.28, -12.97 in-out-out SNCioo out-out ActLoopNT-out 18.4896 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 159.44 APE8-dihe-in -92.55, 126.53 APE8-rot-in 290.06 APE67-dihe-in -62.77, -20.3 -102.35, -28.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.2315 None None None XRAY 3.1 0.233 0.288 B 282.0 262.0 10 30 20 10 [[457, 716]] 1.0 3q96 TKL_BRAF_HUMAN TKL 8e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL IRAK4 IRAK4_HUMAN 4YP8A Q9NWZ3 164 459 460.0 4GF:501 Type1 Active DFGin 6.842 14.1629 BLAminus -130.64, 178.89 61.7, 76.88 -103.53, 25.67 310.66, 96.36 -67.74, -31.55 in-in in 8.7784 Saltbr-in 3.5486 HRD-in -57.79, -50.73 76.7, -3.88 in-in-in SNCiii in-in ActLoopNT-in 2.7748 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.21, 150.97 APE9-dihe-na 140.01, -173.97 APE8-dihe-in -103.61, 115.43 APE8-rot-in 309.9 APE67-dihe-in -66.28, -16.88 -42.43, -50.13 APE12-dist-in 10.0082 APE11-dist-in 11.614 APE10-dist-in 6.3264 APE9-dist-in 3.9176 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 A 301.0 287.0 9 30 26 4 [[183, 456]] 1.0 4yp8 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4YP8B Q9NWZ3 161 459 460.0 4GF:501 Type1 Inactive DFGin 6.9172 14.4445 BLAminus -129.86, 179.56 60.17, 77.95 -104.22, 26.32 310.53, 95.0 -66.78, -33.18 in-out in 8.6851 Saltbr-out 3.9622 HRD-in -57.85, -50.75 76.66, -4.15 out-in-in SNCoii in-in ActLoopNT-in 2.8535 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.74, 150.82 APE9-dihe-na 140.12, -173.75 APE8-dihe-in -103.4, 115.49 APE8-rot-in 310.63 APE67-dihe-in -65.34, -17.03 -41.64, -51.23 APE12-dist-in 10.0453 APE11-dist-in 11.5809 APE10-dist-in 6.3191 APE9-dist-in 3.9048 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 B 301.0 281.0 18 30 24 6 [[183, 456]] 1.0 4yp8 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4YP8C Q9NWZ3 164 460 460.0 4GF:501 Type1 Inactive DFGin 6.8212 14.4085 BLAminus -129.81, 179.51 59.35, 79.05 -103.24, 26.6 309.61, 96.69 -66.38, -34.02 in-out in 8.8507 Saltbr-out 4.6837 HRD-in -59.31, -50.52 77.45, -5.42 out-in-in SNCoii in-in ActLoopNT-in 2.7895 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.88, 150.51 APE9-dihe-na 141.79, -174.18 APE8-dihe-in -103.25, 114.63 APE8-rot-in 311.45 APE67-dihe-in -64.61, -17.76 -41.38, -51.75 APE12-dist-in 10.1488 APE11-dist-in 11.6263 APE10-dist-in 6.34 APE9-dist-in 3.9449 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 C 301.0 290.0 7 30 26 4 [[183, 456]] 1.0 4yp8 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4YP8D Q9NWZ3 164 459 460.0 4GF:501 Type1 Inactive DFGin 6.8543 14.3193 BLAminus -129.62, 178.91 61.84, 77.53 -103.67, 26.43 310.15, 95.74 -66.28, -34.21 in-out in 8.9151 Saltbr-out 3.8024 HRD-in -59.75, -49.91 75.93, -3.95 out-in-in SNCoii in-in ActLoopNT-in 2.7897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.59, 153.02 APE9-dihe-na 138.42, -174.86 APE8-dihe-in -103.4, 114.55 APE8-rot-in 310.75 APE67-dihe-in -64.11, -17.03 -41.21, -51.68 APE12-dist-in 10.0152 APE11-dist-in 11.5854 APE10-dist-in 6.3272 APE9-dist-in 3.9224 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 D 301.0 288.0 8 30 26 4 [[183, 456]] 1.0 4yp8 TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6LXYA Q9NWZ3 163 458 460.0 EXF:501 Type1 Inactive DFGin 6.9967 14.0491 BLAminus -130.85, 177.02 62.25, 85.69 -105.57, 13.21 307.3, 97.03 -58.17, -30.36 in-out in 8.9293 Saltbr-out 5.3622 HRD-in -67.47, -54.1 77.02, 0.48 out-in-in SNCoii in-in ActLoopNT-in 2.8192 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.95, 147.66 APE9-dihe-na 135.07, -175.38 APE8-dihe-in -106.14, 112.07 APE8-rot-in 312.29 APE67-dihe-in -59.29, -20.88 -52.35, -43.4 APE12-dist-in 10.1915 APE11-dist-in 11.7043 APE10-dist-in 6.4389 APE9-dist-in 4.3573 None TPO345,SEP346 TPO345,SEP346 XRAY 2.19 0.202 0.231 A 305.0 294.0 2 30 28 2 [[183, 456]] 1.0 6lxy TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6LXYB Q9NWZ3 163 459 460.0 EXF:502 Type1 None DFGin 6.9731 14.1366 BLAminus -129.45, 177.84 61.74, 86.54 -106.07, 12.43 306.08, 97.48 -57.61, -29.04 in-none in 9.0982 Saltbr-none 999.0 HRD-in -68.65, -53.21 75.68, 1.0 none-in-in SNCnii in-in ActLoopNT-in 2.8068 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.47, 149.33 APE9-dihe-na 135.3, -175.41 APE8-dihe-in -105.49, 112.4 APE8-rot-in 312.11 APE67-dihe-in -59.55, -21.17 -51.5, -42.55 APE12-dist-in 10.1894 APE11-dist-in 11.6864 APE10-dist-in 6.444 APE9-dist-in 4.3325 None TPO345,SEP346 TPO345,SEP346 XRAY 2.19 0.202 0.231 B 305.0 297.0 0 30 30 0 [[183, 456]] 1.0 6lxy TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6LXYD Q9NWZ3 162 459 460.0 EXF:502 Type1 Inactive DFGin 7.0024 14.1156 BLAminus -130.62, 177.55 62.4, 85.91 -106.35, 12.8 307.19, 98.16 -58.64, -30.18 in-out in 8.9428 Saltbr-out 5.3537 HRD-in -67.38, -53.42 77.14, -1.48 out-in-in SNCoii in-in ActLoopNT-in 2.7863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.01, 149.8 APE9-dihe-na 134.89, -175.28 APE8-dihe-in -104.95, 111.45 APE8-rot-in 311.34 APE67-dihe-in -58.57, -21.72 -44.58, -48.25 APE12-dist-in 10.314 APE11-dist-in 11.9545 APE10-dist-in 6.613 APE9-dist-in 4.2536 None TPO345,SEP346 TPO345,SEP346 XRAY 2.19 0.202 0.231 D 305.0 293.0 5 30 25 5 [[183, 456]] 1.0 6lxy TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6LXYE Q9NWZ3 164 458 460.0 EXF:502 Type1 Inactive DFGin 6.9536 14.1587 BLAminus -130.3, 176.57 62.62, 85.73 -105.89, 13.23 306.79, 97.59 -58.45, -29.69 in-out in 8.9309 Saltbr-out 5.3907 HRD-in -66.96, -52.89 76.03, -0.37 out-in-in SNCoii in-in ActLoopNT-in 2.7953 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.25, 150.73 APE9-dihe-na 134.77, -173.9 APE8-dihe-in -105.72, 111.9 APE8-rot-in 311.85 APE67-dihe-in -56.93, -22.86 -45.56, -48.25 APE12-dist-in 10.3091 APE11-dist-in 11.9048 APE10-dist-in 6.6072 APE9-dist-in 4.2918 None TPO345,SEP346 TPO345,SEP346 XRAY 2.19 0.202 0.231 E 305.0 288.0 7 30 23 7 [[183, 456]] 1.0 6lxy TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL MAP3K12 M3K12_HUMAN 5CEQA Q12852 117 398 859.0 50F:4000 Type1 Inactive DFGin 6.2846 14.1433 BLBplus -139.34, 175.24 65.23, 33.46 -103.17, 163.52 57.07, 90.2 71.88, 999.0 out-na out 13.9369 Saltbr-na 13.2447 HRD-in -61.44, -57.14 79.98, -14.5 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -71.43, -48.01 APE9-dihe-na -72.5, -0.08 APE8-dihe-out -118.56, -4.99 APE8-rot-out 184.08 APE67-dihe-in -55.04, -30.89 -63.03, -27.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.1318 None None None XRAY 1.911 0.171 0.218 A 300.0 269.0 13 27 14 13 [[118, 372]] 1.0 5ceq TKL_MAP3K12_HUMAN MAP3K123 1.5e-137 462.8 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
TKL MAP3K7 M3K7_HUMAN 5J9LA O43318 31 496 606.0 6HF:60501 Type1 Inactive DFGout 12.964 7.5747 None -126.7, 106.14 -55.49, -39.75 -39.65, 999.0 105.32, 93.88 999.0, 999.0 in-out in 9.6191 Saltbr-out 4.6621 HRD-in -64.53, -55.8 74.12, -2.79 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 124.52 APE8-dihe-out -91.5, 21.0 APE8-rot-in 299.75 APE67-dihe-in -63.93, -32.31 -64.12, -36.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6997 None None None XRAY 2.752 0.214 0.243 A 307.0 253.0 20 25 11 14 [[36, 286]] 1.0 5j9l TKL_MAP3K7_HUMAN TKL 3.7e-74 255.5 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
TKL RIPK1 RIPK1_HUMAN 7FCZA Q13546 10 294 671.0 3IF:301 Type3 Inactive DFGout 13.8651 10.3793 BBAminus -121.61, 171.92 -133.79, 66.08 -70.41, -22.3 302.99, 177.02 -85.6, 3.29 out-out out 15.0017 Saltbr-out 12.8499 HRD-in -69.8, -48.63 73.26, -13.72 out-out-out SNCooo out-out ActLoopNT-out 6.0735 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 77.72 APE8-dihe-in -67.19, 127.43 APE8-rot-in 294.95 APE67-dihe-in -62.33, -29.47 -101.92, 1.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.4756 C34A,C127A,C233A,C240A None None XRAY 2.21 0.236 0.257 A 297.0 248.0 37 41 23 18 [[17, 287]] 1.0 7fcz TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6.0 265.0 260.0 155 156 157 159 161 45 63 67 135 137 136 138.0 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 7FCZB Q13546 7 294 671.0 3IF:301 Type3 Inactive DFGout 13.9133 10.0278 BBAminus -118.21, 174.22 -136.13, 64.53 -68.29, -24.74 303.09, 178.58 -83.09, -0.43 out-out out 14.1894 Saltbr-out 12.5753 HRD-in -73.47, -53.47 80.61, -17.48 out-out-out SNCooo out-out ActLoopNT-out 6.1388 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 101.37 APE8-dihe-in -64.4, 143.44 APE8-rot-out 179.16 APE67-dihe-in -62.08, -29.26 -100.06, -1.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.6339 C34A,C127A,C233A,C240A None None XRAY 2.21 0.236 0.257 B 297.0 263.0 25 41 24 17 [[17, 287]] 1.0 7fcz TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6.0 265.0 260.0 155 156 157 159 161 45 63 67 135 137 136 138.0 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL TGFBR1 TGFR1_HUMAN 2WOUA P36897 200 496 503.0 ZZF:61500 Type1 Active DFGin 6.1243 13.0393 BLAminus -133.49, -169.53 51.05, 62.4 -92.04, 13.34 298.31, 178.69 -62.77, -27.98 in-in in 7.5857 Saltbr-in 2.7517 HRD-in -65.52, -56.03 81.95, -3.97 in-in-in SNCiii in-in ActLoopNT-in 3.039 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -95.77, -22.31 APE9-dihe-na -79.77, -172.15 APE8-dihe-in -73.94, 125.36 APE8-rot-in 306.35 APE67-dihe-in -52.11, -29.79 -56.64, -45.19 APE12-dist-in 13.0776 APE11-dist-in 11.9354 APE10-dist-in 6.0414 APE9-dist-in 3.6288 None None None XRAY 2.3 0.229 0.302 A 306.0 297.0 0 32 32 0 [[205, 494]] 1.0 2wou TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 3FAAA P36897 171 500 503.0 55F:601 Type1 Active DFGin 5.9037 13.0472 BLAminus -165.74, 163.41 74.29, 54.12 -79.67, 24.05 317.06, 176.62 -56.68, -51.28 in-in in 8.0011 Saltbr-in 2.9364 HRD-in -45.11, -27.8 52.25, 11.68 in-in-in SNCiii in-in ActLoopNT-in 3.1109 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.43, -171.19 APE9-dihe-na 80.03, 171.79 APE8-dihe-in -67.98, 121.11 APE8-rot-in 302.91 APE67-dihe-in -99.71, -73.49 -46.09, -5.99 APE12-dist-in 11.6243 APE11-dist-in 11.9673 APE10-dist-in 6.0149 APE9-dist-in 4.0613 None None None XRAY 3.35 0.228 0.271 A 342.0 328.0 2 32 30 2 [[205, 494]] 1.0 3faa TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 3FAAB P36897 171 501 503.0 55F:601 Type1 Active DFGin 6.0174 13.3063 BLAminus -136.45, -176.24 60.04, 54.86 -81.47, 12.98 307.95, 5.19 -52.57, -45.29 in-in in 8.0996 Saltbr-in 3.0373 HRD-in -75.89, -39.75 60.74, 14.93 in-in-in SNCiii in-in ActLoopNT-in 3.1146 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.32, 175.24 APE9-dihe-na 101.52, 166.7 APE8-dihe-in -70.87, 127.35 APE8-rot-in 315.28 APE67-dihe-in -36.34, -44.33 -43.95, -69.54 APE12-dist-in 11.9404 APE11-dist-in 11.9996 APE10-dist-in 6.3733 APE9-dist-in 4.0844 None None None XRAY 3.35 0.228 0.271 B 342.0 324.0 7 32 29 3 [[205, 494]] 1.0 3faa TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 3FAAC P36897 171 500 503.0 55F:601 Type1 Inactive DFGin 6.142 13.1414 BLAminus -126.27, 176.42 50.71, 78.49 -102.58, 30.06 320.3, 19.34 -66.31, -17.95 in-in in 7.9903 Saltbr-in 2.6623 HRD-in -67.56, -21.99 46.1, 19.37 in-in-out SNCiio in-out ActLoopNT-in 2.947 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiii APE10-dihe-na -120.66, 131.05 APE9-dihe-na 148.7, 175.0 APE8-dihe-in -102.93, 87.73 APE8-rot-in 305.5 APE67-dihe-out -28.83, -55.82 5.18, -84.04 APE12-dist-in 11.4809 APE11-dist-in 12.1489 APE10-dist-in 6.2467 APE9-dist-in 4.208 None None None XRAY 3.35 0.228 0.271 C 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 3faa TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 3FAAD P36897 171 500 503.0 55F:601 Type1 Active DFGin 6.2595 13.1679 BLAminus -151.5, 176.63 62.94, 64.2 -90.99, 26.98 302.19, 4.38 -66.56, -19.34 in-in in 7.8095 Saltbr-in 2.7451 HRD-in -63.44, -55.82 78.14, 1.44 in-in-in SNCiii in-in ActLoopNT-in 2.8034 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.86, 174.28 APE9-dihe-na 87.09, 173.14 APE8-dihe-in -66.87, 116.28 APE8-rot-in 325.42 APE67-dihe-in -60.47, -38.15 -48.63, -36.35 APE12-dist-in 11.7136 APE11-dist-in 11.8944 APE10-dist-in 6.3705 APE9-dist-in 4.2294 None None None XRAY 3.35 0.228 0.271 D 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 3faa TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 3FAAE P36897 171 500 503.0 55F:601 Type1 Active DFGin 6.355 13.3659 BLAminus -131.48, -168.05 37.37, 86.28 -107.7, 26.02 296.92, 176.17 -65.92, -19.56 in-in in 7.7814 Saltbr-in 3.0945 HRD-in -66.77, -57.93 79.95, 12.98 in-in-in SNCiii in-in ActLoopNT-in 2.8502 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.13, 169.87 APE9-dihe-na 90.72, 172.5 APE8-dihe-in -64.72, 129.04 APE8-rot-in 310.98 APE67-dihe-in -56.46, -40.64 -59.57, -42.14 APE12-dist-in 11.9901 APE11-dist-in 12.0559 APE10-dist-in 6.5703 APE9-dist-in 3.9816 None None None XRAY 3.35 0.228 0.271 E 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 3faa TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR2 TGFR2_HUMAN 7DV6A P37173 240 543 567.0 HJF:9000 Type1 Active DFGin 7.1311 13.4318 BLAminus -156.15, -164.95 57.9, 60.45 -93.44, 15.51 294.56, 110.64 -56.6, -36.89 in-in in 7.4443 Saltbr-in 2.6595 HRD-in -60.78, -51.79 74.77, -4.11 in-in-in SNCiii in-in ActLoopNT-in 2.8603 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.14, 141.57 APE9-dihe-na 113.33, -173.4 APE8-dihe-in -82.04, 128.94 APE8-rot-in 303.35 APE67-dihe-in -55.96, -36.36 -60.86, -38.17 APE12-dist-in 11.5078 APE11-dist-in 11.8903 APE10-dist-in 6.0465 APE9-dist-in 3.9117 E431A,R433A,E485A,K488A,R493A,R495A None None XRAY 2.39 0.163 0.224 A 323.0 304.0 0 32 32 0 [[244, 540]] 1.0 7dv6 TKL_TGFBR2_HUMAN TKL 2.1e-77 266.2 2.0 266.0 265.0 396 397 398 400 402 277 290 294 376 378 377 379.0 446 428 423 422 421 420 419 418 417 326 TGF-beta receptor type-2
TYR ALK ALK_HUMAN 4CCUA Q9UM73 1093 1402 1620.0 AWF:1500 Type1 Inactive DFGin 6.0199 14.6231 ABAminus -118.73, -9.8 -132.17, 139.04 -133.56, 37.48 295.42, 86.35 -74.53, -27.89 in-out in 8.2766 Saltbr-out 4.6887 HRD-in -77.94, -47.73 82.62, -10.67 out-out-out SNCooo out-out ActLoopNT-out 6.8034 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.98, -27.23 APE9-dihe-in -56.62, 135.11 APE8-dihe-in -75.38, 65.75 APE8-rot-na 29.29 APE67-dihe-in -70.29, -14.23 -60.1, -29.45 APE12-dist-na 14.5251 APE11-dist-na 15.1704 APE10-dist-na 10.0283 APE9-dist-in 7.7958 None None None XRAY 2.0 0.202 0.233 A 327.0 293.0 17 30 24 6 [[1116, 1385]] 1.0 4ccu TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 4FNZA Q9UM73 1093 1402 1620.0 NZF:1501 Type1 Inactive DFGin 5.291 12.7997 ABAminus -135.46, 12.02 -152.76, 153.63 -83.97, -38.55 283.31, 122.35 73.66, 999.0 in-in in 8.5004 Saltbr-in 2.8123 HRD-in -72.66, -49.3 78.9, -9.45 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -97.65, -24.93 APE9-dihe-in -50.61, 132.71 APE8-dihe-in -79.34, 69.48 APE8-rot-na 27.73 APE67-dihe-in -74.42, -13.21 -56.44, -36.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8304 C1097S None None XRAY 2.6 0.202 0.261 A 327.0 287.0 23 30 15 15 [[1116, 1385]] 1.0 4fnz TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 4DCEA Q9UM73 1093 1402 1620.0 0JF:1501 Type1 Inactive DFGin 5.6296 13.8228 None -137.27, 16.47 -161.52, 152.14 -94.73, 164.26 291.72, 122.64 -76.17, 999.0 in-in in 8.4822 Saltbr-in 2.8829 HRD-in -75.4, -48.78 85.77, -10.33 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -96.83, -20.84 APE9-dihe-in -55.51, 136.7 APE8-dihe-in -77.28, 70.08 APE8-rot-na 28.6 APE67-dihe-in -68.31, -8.92 -56.77, -41.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.9739 C1097S None None XRAY 2.03 0.211 0.256 A 333.0 288.0 22 30 16 14 [[1116, 1385]] 1.0 4dce TYR_ALK_HUMAN TYR 1.5e-90 309.0 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 4DCEB Q9UM73 1094 1402 1620.0 0JF:1501 Type1 Inactive DFGin 5.7474 13.6282 None -141.04, 18.73 -165.26, 150.02 -96.5, 167.37 286.77, 120.17 -70.38, 999.0 in-in in 8.5634 Saltbr-in 2.9896 HRD-in -72.56, -48.26 83.87, -14.3 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -96.41, -12.56 APE9-dihe-in -59.98, 136.0 APE8-dihe-in -80.48, 64.18 APE8-rot-na 31.8 APE67-dihe-in -66.1, -14.3 -52.07, -41.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.7127 C1097S None None XRAY 2.03 0.211 0.256 B 333.0 284.0 25 30 15 15 [[1116, 1385]] 1.0 4dce TYR_ALK_HUMAN TYR 1.5e-90 309.0 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR BTK BTK_HUMAN 5FBNC Q06187 395 658 659.0 5WF:701,5WE:702 Type1.5_Front,Allosteric Inactive DFGin 6.2343 13.4854 BLBplus -138.97, 172.93 64.41, 21.2 -64.91, 134.85 43.34, 89.93 78.28, -17.1 out-out out 15.0072 Saltbr-out 15.714 HRD-in -67.81, -54.89 86.66, -24.42 out-out-out SNCooo out-out ActLoopNT-out 8.1944 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out 143.31, -31.01 APE9-dihe-in -63.12, 135.49 APE8-dihe-in -76.38, 65.1 APE8-rot-na 32.35 APE67-dihe-in -72.98, -10.12 -50.46, -47.16 APE12-dist-na 999.0 APE11-dist-na 17.8308 APE10-dist-na 12.6083 APE9-dist-out 8.1809 None None None XRAY 1.8 0.182 0.226 C 271.0 256.0 8 29 21 8 [[402, 653]] 1.0 5fbn TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 5FBND Q06187 394 658 659.0 5WF:702,5WE:703,5WE:704,5WE:705 Type1.5_Front,Allosteric,Allosteric,Allosteric Inactive DFGin 6.2504 13.4724 BLBplus -137.76, 172.64 65.66, 19.16 -62.24, 135.48 45.56, 88.91 74.32, -16.76 out-out out 15.0558 Saltbr-out 15.7515 HRD-in -65.32, -54.88 86.04, -26.38 out-out-none SNCoon out-none ActLoopNT-out 8.1947 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.18 APE8-dihe-in -78.24, 64.6 APE8-rot-na 31.95 APE67-dihe-in -74.36, -8.3 -50.81, -46.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8979 None None None XRAY 1.8 0.182 0.226 D 271.0 255.0 10 29 19 10 [[402, 653]] 1.0 5fbn TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR DDR1 DDR1_HUMAN 5SAUA Q08345 604 912 913.0 1IF:61000 Type2 Inactive DFGout 12.6278 9.6718 BBAminus -137.39, -170.54 -153.95, 108.1 -100.48, 5.9 289.81, 101.12 83.39, -174.73 in-in in 8.355 Saltbr-in 2.8692 HRD-in -71.66, -48.67 82.15, -10.52 in-out-in SNCioi out-in ActLoopNT-out 18.1388 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.56, 139.94 APE9-dihe-in -129.66, 123.98 APE8-dihe-in -80.56, 70.77 APE8-rot-na 35.49 APE67-dihe-in -73.85, -9.33 -63.13, -31.85 APE12-dist-na 13.3308 APE11-dist-na 10.3117 APE10-dist-na 5.8844 APE9-dist-in 7.5547 None None None XRAY 1.8 0.201 0.231 A 321.0 287.0 16 30 30 0 [[610, 907]] 1.0 5sau TYR_DDR1_HUMAN TYR 1.4e-92 315.7 1.0 260.0 260.0 783 784 785 787 789 655 672 676 763 765 764 766.0 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR EPHA2 EPHA2_HUMAN 8BOCA P29317 605 888 976.0 QUF:1001 Type2 Inactive DFGout 13.5834 10.813 BBAminus -139.62, -179.28 -151.24, 106.28 -78.98, -6.2 302.64, 171.21 84.05, 5.79 in-in in 8.8689 Saltbr-in 3.5006 HRD-in -70.68, -54.7 83.35, -19.69 in-out-in SNCioi out-in ActLoopNT-out 12.2476 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.53, 160.37 APE9-dihe-in -116.01, 148.45 APE8-dihe-in -79.02, 97.78 APE8-rot-na 34.23 APE67-dihe-in -77.84, -8.8 -56.96, -40.4 APE12-dist-na 12.8439 APE11-dist-na 9.3252 APE10-dist-na 7.8923 APE9-dist-in 5.837 None None None XRAY 1.9 0.248 0.286 A 306.0 271.0 13 31 31 0 [[613, 873]] 1.0 8boc TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2.0 261.0 260.0 756 757 758 760 762 646 663 667 736 738 737 739.0 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHB4 EPHB4_HUMAN 2X9FA P54760 608 888 987.0 X9F:1889 Type1 Inactive DFGin 6.2077 14.3304 BLBminus -134.1, -172.08 65.01, 71.96 -106.66, 162.22 301.36, 107.12 163.16, 158.85 in-in in 7.543 Saltbr-in 2.7028 HRD-in -73.92, -48.13 77.71, -16.54 in-out-in SNCioi out-in ActLoopNT-out 9.7905 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.56, 149.08 APE9-dihe-in -55.67, 129.32 APE8-dihe-in -83.14, 89.74 APE8-rot-na 29.6 APE67-dihe-in -62.34, -22.56 -52.45, -48.78 APE12-dist-na 8.3626 APE11-dist-na 11.4167 APE10-dist-na 15.4162 APE9-dist-in 6.3395 Y774E None None XRAY 1.75 0.159 0.194 A 302.0 265.0 16 33 20 13 [[615, 876]] 1.0 2x9f TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2.0 261.0 260.0 757 758 759 761 763 647 664 668 737 739 738 740.0 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR FGFR1 FGFR1_HUMAN 9UHIA P11362 458 764 822.0 A1EPF:60801 Type1 Inactive DFGin 5.058 13.4362 BLAplus -111.91, 163.26 62.65, 26.85 -80.22, -19.74 58.59, 88.0 -94.12, 4.52 in-in in 8.2512 Saltbr-in 2.8878 HRD-in -74.14, -50.3 78.02, -11.1 in-out-out SNCioo out-out ActLoopNT-out 7.5114 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -88.77, 149.44 APE9-dihe-in -108.01, 98.39 APE8-dihe-out -63.46, -15.87 APE8-rot-na 3.35 APE67-dihe-in -71.69, -10.38 -55.45, -26.93 APE12-dist-na 17.216 APE11-dist-na 19.6718 APE10-dist-na 16.6848 APE9-dist-out 11.0826 None None None XRAY 1.76 0.163 0.197 A 310.0 307.0 0 30 30 0 [[478, 756]] 1.0 9uhi TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 9UHIB P11362 458 763 822.0 A1EPF:60801 Type1 Inactive DFGin 5.2132 12.7377 BLAplus -108.15, 164.77 66.41, 24.28 -84.34, -17.16 58.96, 83.83 -89.87, -8.4 in-in in 7.7681 Saltbr-in 3.4492 HRD-in -77.39, -52.67 76.89, -15.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -74.45, 132.66 APE9-dihe-in -102.74, 93.19 APE8-dihe-out -60.68, -21.29 APE8-rot-na 332.28 APE67-dihe-in -72.11, -2.38 -56.87, -27.58 APE12-dist-na 17.3515 APE11-dist-na 20.6822 APE10-dist-na 16.9654 APE9-dist-out 11.3637 None None None XRAY 1.76 0.163 0.197 B 310.0 286.0 20 30 23 7 [[478, 756]] 1.0 9uhi TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 3C4FA P11362 464 765 822.0 C4F:1 Type1.5_Back Inactive DFGin 5.1138 13.3182 BLAplus -110.44, 159.78 58.59, 34.58 -81.02, -11.31 51.22, 81.2 -119.48, 23.64 in-out in 7.8662 Saltbr-out 4.6321 HRD-in -67.82, -57.48 84.79, -17.47 out-out-out SNCooo out-out ActLoopNT-out 9.0691 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -97.31, 173.6 APE9-dihe-in -111.71, 110.92 APE8-dihe-out -49.57, -28.9 APE8-rot-na 335.93 APE67-dihe-in -76.49, -6.67 -57.78, -16.15 APE12-dist-na 19.2924 APE11-dist-na 21.1206 APE10-dist-na 19.3954 APE9-dist-out 11.7567 C488A None None XRAY 2.07 0.213 0.264 A 302.0 290.0 12 30 30 0 [[478, 756]] 1.0 3c4f TYR_FGFR1_HUMAN TYR 1.3e-104 355.0 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 3C4FB P11362 464 765 822.0 C4F:2 Type1.5_Back Inactive DFGin 5.1863 13.0956 BLAplus -113.87, 161.2 54.21, 44.76 -88.95, -14.38 49.14, 89.01 -114.94, 24.21 in-in in 7.8308 Saltbr-in 3.2478 HRD-in -69.91, -54.09 86.4, -33.67 in-out-out SNCioo out-out ActLoopNT-out 8.9335 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.54, 164.12 APE9-dihe-in -103.97, 111.75 APE8-dihe-out -49.46, -30.24 APE8-rot-na 330.07 APE67-dihe-in -74.8, -7.14 -56.82, -17.81 APE12-dist-na 19.3702 APE11-dist-na 21.2959 APE10-dist-na 19.6706 APE9-dist-out 11.6434 C488A None None XRAY 2.07 0.213 0.264 B 302.0 290.0 12 30 30 0 [[478, 756]] 1.0 3c4f TYR_FGFR1_HUMAN TYR 1.3e-104 355.0 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 5EW8A P11362 464 765 822.0 5SF:803 Type1.5_Back Inactive DFGin 4.9481 13.2646 BLAplus -106.94, 161.6 53.73, 34.99 -75.93, -13.84 56.0, 83.89 -112.21, 7.75 in-in in 7.9544 Saltbr-in 2.8007 HRD-in -68.23, -51.53 79.48, -14.26 in-out-out SNCioo out-out ActLoopNT-out 9.0673 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.87, 162.8 APE9-dihe-in -100.01, 112.78 APE8-dihe-out -57.6, -21.18 APE8-rot-na 333.77 APE67-dihe-in -70.4, -6.07 -56.33, -25.26 APE12-dist-na 19.3705 APE11-dist-na 20.7434 APE10-dist-na 19.2162 APE9-dist-out 11.8815 None None None XRAY 1.63 0.186 0.206 A 309.0 291.0 11 30 30 0 [[478, 756]] 1.0 5ew8 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 5EW8B P11362 461 765 822.0 5SF:802 Type1.5_Back Inactive DFGin 5.0015 13.1238 BLAplus -109.75, 160.16 55.05, 34.73 -78.35, -12.87 54.65, 85.31 -106.64, 12.94 in-in in 7.8796 Saltbr-in 2.8072 HRD-in -67.52, -52.32 78.89, -12.97 in-out-out SNCioo out-out ActLoopNT-out 8.3799 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.81, 162.42 APE9-dihe-in -99.2, 111.94 APE8-dihe-out -57.42, -21.49 APE8-rot-na 334.53 APE67-dihe-in -69.99, -6.88 -56.65, -24.13 APE12-dist-na 19.9019 APE11-dist-na 21.1689 APE10-dist-na 19.6545 APE9-dist-out 11.7665 None None None XRAY 1.63 0.186 0.206 B 309.0 290.0 15 30 28 2 [[478, 756]] 1.0 5ew8 TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 7WCLA P11362 459 764 822.0 8ZF:60801 Type1.5_Back Inactive DFGin 5.0323 13.5114 BLAplus -110.65, 158.43 54.71, 42.71 -89.1, -11.93 53.54, 87.56 -114.63, 26.86 in-in in 8.2337 Saltbr-in 2.9434 HRD-in -65.51, -45.04 70.13, -0.28 in-out-out SNCioo out-out ActLoopNT-out 7.9796 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -98.05, 142.67 APE9-dihe-in -99.82, 98.85 APE8-dihe-out -66.04, -10.56 APE8-rot-na 23.45 APE67-dihe-in -75.78, -2.11 -60.96, -29.19 APE12-dist-na 16.7251 APE11-dist-na 19.0668 APE10-dist-na 16.2264 APE9-dist-out 11.2235 C584S None None XRAY 2.495 0.195 0.23 A 310.0 306.0 0 30 30 0 [[478, 756]] 1.0 7wcl TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 7WCLB P11362 458 763 822.0 8ZF:60801 Type1.5_Back Inactive DFGin 5.6863 13.2974 BLAplus -116.0, 164.36 53.53, 38.11 -89.51, -19.74 50.41, 88.95 -102.65, 11.92 in-in in 8.3808 Saltbr-in 2.8041 HRD-in -77.55, -44.61 69.5, -1.67 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -124.03, 166.88 APE9-dihe-in -112.63, 116.79 APE8-dihe-out -58.21, -18.36 APE8-rot-na 340.54 APE67-dihe-in -81.23, 2.92 -65.55, -20.31 APE12-dist-na 18.6 APE11-dist-na 21.6055 APE10-dist-na 19.4985 APE9-dist-out 11.4021 C584S None None XRAY 2.495 0.195 0.23 B 310.0 285.0 21 30 22 8 [[478, 756]] 1.0 7wcl TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR3 FGFR3_HUMAN 8UDTA P22607 457 756 806.0 MLT:61001,MLT:61002,WGF:61003 Allosteric,Allosteric,Type1.5_Front Inactive DFGin 5.4408 13.493 BLAplus -114.8, 158.79 55.69, 43.2 -82.19, -34.37 42.84, 89.08 -83.27, -4.41 in-out in 8.3828 Saltbr-out 5.2872 HRD-in -68.34, -46.54 75.89, -9.4 out-out-out SNCooo out-out ActLoopNT-out 7.9211 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 112.29 APE8-dihe-out -63.06, -32.23 APE8-rot-na 340.92 APE67-dihe-in -68.35, -26.42 -62.13, -28.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.1982 P572S,P573G None None XRAY 2.829 0.263 0.274 A 297.0 284.0 4 30 26 4 [[472, 750]] 1.0 8udt TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 8UDTB P22607 457 754 806.0 WGF:62001 Type1.5_Front Inactive DFGin 5.2581 13.7103 BLAplus -108.64, 157.87 56.15, 40.62 -79.39, -35.54 45.72, 88.06 -80.67, 0.1 in-out in 8.4451 Saltbr-out 5.3977 HRD-in -67.98, -43.8 74.91, -8.8 out-out-out SNCooo out-out ActLoopNT-out 7.8672 ActLoopCT-out TYR APEdihe_nooai APEdist_aaao APE10-dihe-none 999.0, -64.67 APE9-dihe-out -68.82, -39.67 APE8-dihe-out -56.45, -17.85 APE8-rot-na 337.42 APE67-dihe-in -61.76, -27.35 -59.02, -40.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.6665 APE9-dist-out 10.854 P572S,P573G None None XRAY 2.829 0.263 0.274 B 297.0 283.0 3 30 27 3 [[472, 750]] 1.0 8udt TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 8UDTC P22607 457 756 806.0 WGF:62001 Type1.5_Front Inactive DFGin 5.2583 13.8238 BLAplus -109.74, 157.08 55.91, 40.67 -78.94, -35.79 45.97, 87.77 -81.04, -4.46 in-out in 8.545 Saltbr-out 4.1026 HRD-in -68.09, -46.3 75.11, -4.3 out-out-out SNCooo out-out ActLoopNT-out 7.8702 ActLoopCT-out TYR APEdihe_nooai APEdist_aaao APE10-dihe-none 999.0, -150.08 APE9-dihe-out -67.3, -42.56 APE8-dihe-out -46.98, -31.66 APE8-rot-na 333.46 APE67-dihe-in -60.08, -29.46 -58.03, -43.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.4047 APE9-dist-out 11.049 P572S,P573G None None XRAY 2.829 0.263 0.274 C 297.0 284.0 4 30 26 4 [[472, 750]] 1.0 8udt TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR4 FGFR4_HUMAN 7WCXA P22455 453 752 802.0 90F:801 Type1 Inactive DFGin 5.2632 13.1414 BLAplus -114.81, 160.0 54.39, 48.08 -89.68, -16.38 44.55, 83.39 -109.65, 26.27 in-in in 7.7923 Saltbr-in 2.5114 HRD-in -76.2, -43.73 72.01, -8.39 in-out-out SNCioo out-out ActLoopNT-out 8.6444 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -80.24, 137.24 APE9-dihe-in -109.54, 93.42 APE8-dihe-out -57.65, -19.77 APE8-rot-na 335.57 APE67-dihe-in -71.93, -5.42 -64.19, -25.82 APE12-dist-na 19.0736 APE11-dist-na 20.85 APE10-dist-na 16.8219 APE9-dist-out 11.9043 C477A,R664E None None XRAY 2.175 0.173 0.221 A 309.0 300.0 0 30 30 0 [[467, 745]] 1.0 7wcx TYR_FGFR4_HUMAN TYR 7e-101 342.8 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 7WCWA P22455 453 752 802.0 90F:801 Type1 Inactive DFGin 5.8394 13.063 BLAplus -123.48, 161.59 54.95, 50.1 -96.76, -24.53 39.59, 83.16 -101.63, 31.89 in-in in 7.5817 Saltbr-in 3.4 HRD-in -77.43, -45.16 72.65, -7.54 in-out-out SNCioo out-out ActLoopNT-out 8.6329 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -81.49, 135.61 APE9-dihe-in -107.87, 94.77 APE8-dihe-out -59.45, -18.22 APE8-rot-na 336.81 APE67-dihe-in -74.15, -1.22 -67.3, -23.03 APE12-dist-na 19.4349 APE11-dist-na 20.9958 APE10-dist-na 16.9286 APE9-dist-out 11.8399 C477A,R664E None None XRAY 2.317 0.179 0.221 A 309.0 300.0 0 30 30 0 [[467, 745]] 1.0 7wcw TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 6JPJA P22455 454 752 802.0 FGF:800 Type1 Inactive DFGin 5.301 12.6584 BLAplus -117.71, 161.57 53.08, 42.72 -89.02, -4.4 50.47, 87.12 -117.52, 24.43 in-in in 7.2473 Saltbr-in 2.3178 HRD-out -71.89, 98.16 -78.45, 15.53 in-out-out SNCioo out-out ActLoopNT-out 8.0019 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -85.03, 139.81 APE9-dihe-in -112.83, 87.62 APE8-dihe-out -50.76, -19.28 APE8-rot-na 332.54 APE67-dihe-in -80.03, 5.83 -68.35, -18.64 APE12-dist-na 19.2943 APE11-dist-na 21.0682 APE10-dist-na 17.1289 APE9-dist-out 12.054 C477A,R664E None None XRAY 2.638 0.198 0.243 A 311.0 299.0 0 30 30 0 [[467, 745]] 1.0 6jpj TYR_FGFR4_HUMAN TYR 1.3e-100 341.9 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 7VJLA P22455 454 753 802.0 7IF:801 Type1 Inactive DFGin 5.3011 12.4196 BLAplus -114.78, 170.3 57.71, 40.42 -94.32, 21.48 55.77, 90.38 -107.29, 999.0 in-in in 7.4851 Saltbr-in 2.9035 HRD-out -79.19, -58.83 -98.34, 2.36 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 2.26 APE8-rot-na 31.94 APE67-dihe-in -59.38, -20.97 -56.11, -39.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.212 0.273 A 301.0 263.0 37 30 11 19 [[467, 745]] 1.0 7vjl TYR_FGFR4_HUMAN TYR 1.1e-100 342.2 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 7VJLB P22455 453 753 802.0 7IF:801 Type1 Inactive DFGin 5.4049 13.2037 BLAplus -123.58, 175.88 60.77, 35.86 -95.6, 5.83 48.51, 81.65 -122.94, 999.0 in-in in 7.8757 Saltbr-in 2.6652 HRD-out -72.76, -57.66 -103.85, -18.8 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 6.57 APE8-rot-na 30.25 APE67-dihe-in -55.58, -34.43 -70.09, -36.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.212 0.273 B 301.0 266.0 35 30 11 19 [[467, 745]] 1.0 7vjl TYR_FGFR4_HUMAN TYR 1.1e-100 342.2 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 6YI8A P22455 453 753 802.0 FGF:801 Type1 Inactive DFGin 5.0516 12.5848 BLAplus -114.37, 162.1 61.01, 37.7 -86.22, -22.44 57.75, 86.82 -88.83, -1.63 in-in in 7.21 Saltbr-in 2.807 HRD-in -68.35, -54.97 79.66, -18.38 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 137.99 APE9-dihe-in -91.08, 144.79 APE8-dihe-in -80.88, 56.75 APE8-rot-na 32.63 APE67-dihe-in -69.74, -13.54 -50.67, -37.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 19.1286 APE9-dist-out 9.5625 None None None XRAY 2.13 0.198 0.231 A 307.0 277.0 24 30 15 15 [[467, 745]] 1.0 6yi8 TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 6YI8B P22455 451 752 802.0 FGF:801 Type1 Inactive DFGin 5.5513 13.0744 BLAplus -114.83, 168.14 49.73, 54.77 -99.35, -32.03 46.0, 89.99 -71.98, 999.0 in-in in 7.3993 Saltbr-in 2.8136 HRD-in -67.69, -51.4 79.31, -36.01 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.49 APE8-dihe-in -88.73, 63.1 APE8-rot-na 25.93 APE67-dihe-in -70.74, -12.22 -53.82, -35.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.0812 None None None XRAY 2.13 0.198 0.231 B 307.0 270.0 32 30 12 18 [[467, 745]] 1.0 6yi8 TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 7WCTA P22455 453 752 802.0 90F:801 Type1 Inactive DFGin 5.4993 13.0077 BLAplus -115.75, 158.15 54.59, 44.67 -82.33, -22.35 42.51, 87.35 -106.03, 33.12 in-in in 7.4757 Saltbr-in 2.8808 HRD-in -76.31, -44.07 70.33, -3.05 in-out-out SNCioo out-out ActLoopNT-out 8.4968 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -84.18, 139.68 APE9-dihe-in -111.32, 93.14 APE8-dihe-out -55.09, -20.87 APE8-rot-na 333.3 APE67-dihe-in -74.74, -3.5 -65.15, -23.14 APE12-dist-na 19.4627 APE11-dist-na 21.0452 APE10-dist-na 17.0744 APE9-dist-out 11.7717 R664E None None XRAY 2.106 0.184 0.217 A 311.0 300.0 0 30 30 0 [[467, 745]] 1.0 7wct TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 5XFJA P22455 453 750 802.0 6LF:801 Type1 Inactive DFGin 5.0214 13.2508 None -115.6, 133.16 70.83, 138.96 -157.69, 175.22 19.16, 82.91 -161.9, 174.05 in-out in 8.3097 Saltbr-out 4.2744 HRD-out -142.96, 112.57 -85.34, -51.29 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -47.84 APE8-dihe-in -93.04, 75.41 APE8-rot-na 34.31 APE67-dihe-in -59.81, -17.88 -81.83, -32.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.229 V550M None None XRAY 3.25 0.284 0.336 A 311.0 266.0 32 30 13 17 [[467, 745]] 1.0 5xfj TYR_FGFR4_HUMAN TYR 4.5e-101 343.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 5XFFA P22455 453 750 802.0 6LF:801 Type1 Inactive DFGin 7.2509 13.8003 None -91.81, 157.14 71.12, 141.83 -151.53, 140.75 303.34, 100.5 -174.03, 158.26 in-in in 7.9065 Saltbr-in 3.5618 HRD-out -144.83, 101.6 -75.14, -41.6 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -18.13 APE8-dihe-in -83.47, 67.75 APE8-rot-na 31.32 APE67-dihe-in -75.73, 1.3 -73.66, -27.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.5407 V550L None None XRAY 2.7 0.27 0.32 A 311.0 269.0 29 30 13 17 [[467, 745]] 1.0 5xff TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 5JKGA P22455 453 750 802.0 6LF:801 Type1 Inactive DFGin 4.645 13.4149 None -80.35, 138.57 42.13, 154.03 -151.26, -44.79 29.5, 89.83 59.57, 154.84 in-in in 7.7877 Saltbr-in 2.7483 HRD-out -157.35, 80.6 -45.38, -51.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -51.98 APE8-dihe-in -77.75, 74.49 APE8-rot-na 28.85 APE67-dihe-in -78.7, 0.61 -72.33, -28.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.4055 None None None XRAY 2.352 0.237 0.277 A 311.0 266.0 32 30 13 17 [[467, 745]] 1.0 5jkg TYR_FGFR4_HUMAN TYR 8.4e-101 342.6 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FLT3 FLT3_HUMAN 6JQRA P36888 571 951 993.0 C6F:1001 Type1 Inactive DFGout 15.3937 10.8847 None -119.73, 157.71 -104.23, 115.68 77.2, 999.0 255.94, 91.42 999.0, 999.0 in-in in 8.3262 Saltbr-in 2.8041 HRD-out -98.26, 117.82 -85.48, 11.47 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -131.05, 100.76 APE9-dihe-in -103.87, 123.04 APE8-dihe-in -78.74, 70.62 APE8-rot-na 34.5 APE67-dihe-in -69.1, -11.06 -54.04, -46.43 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.223 None None None XRAY 2.2 0.181 0.213 A 330.0 301.0 29 30 24 6 [[610, 945]] 1.0 6jqr TYR_FLT3_HUMAN TYR 8.5e-103 349.1 1.0 259.0 259.0 828 829 830 832 834 644 661 665 808 810 809 811.0 870 858 853 852 851 850 849 848 847 692 Receptor-type tyrosine-protein kinase FLT3
TYR HCK HCK_HUMAN 3VS4A P08631 81 526 526.0 VSF:60603 Type1.5_Back Inactive DFGin 5.2959 12.6167 BLBplus -129.05, 156.5 78.18, 7.28 -55.31, 122.08 48.34, 94.72 91.65, -36.18 out-out out 13.5298 Saltbr-out 14.391 HRD-in -89.51, -57.9 84.08, -11.13 out-out-out SNCooo out-out ActLoopNT-out 6.8746 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 47.3 APE8-dihe-in -93.7, 67.91 APE8-rot-na 28.82 APE67-dihe-in -68.45, -16.47 -64.44, -22.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.6975 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.747 0.265 0.265 A 454.0 429.0 11 29 18 11 [[262, 513]] 1.0 3vs4 TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 3VS4B P08631 81 526 526.0 VSF:60603 Type1.5_Back Inactive DFGin 5.2845 12.6652 BLBplus -120.89, 167.83 61.49, 15.86 -62.02, 121.53 47.24, 95.4 75.03, 10.7 out-out out 13.7661 Saltbr-out 15.0419 HRD-in -94.45, -46.27 74.87, -7.2 out-out-out SNCooo out-out ActLoopNT-out 7.1349 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 48.23 APE8-dihe-in -84.31, 74.96 APE8-rot-na 34.0 APE67-dihe-in -71.24, -2.76 -88.69, -13.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.5953 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.747 0.265 0.265 B 454.0 434.0 12 29 17 12 [[262, 513]] 1.0 3vs4 TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR JAK2-1 JAK2_HUMAN 8B9EA O60674 536 809 1132.0 Q7F:1003 Type1 Pseudo DFGin 5.7694 13.2256 None -72.27, 175.04 -67.31, 162.54 -76.41, -26.42 340.6, 33.67 78.05, -163.23 out-na out 11.7256 Saltbr-na 999.0 HRD-in -83.9, -60.17 88.41, -6.41 na-out-out SNCaoo out-out ActLoopNT-out 8.9495 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.18, -39.02 APE9-dihe-out -59.74, -28.13 APE8-dihe-out -86.36, 6.28 APE8-rot-na 284.57 APE67-dihe-out -105.41, 26.85 -68.63, 134.78 APE12-dist-na 9.6132 APE11-dist-na 11.3156 APE10-dist-na 15.8543 APE9-dist-out 12.1058 W777A,F794H None None XRAY 1.5 0.17 0.194 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8b9e TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B9HA O60674 536 809 1132.0 Q7F:901 Type1 Pseudo DFGin 6.0102 13.3074 None -84.93, -177.89 -74.12, 157.3 -67.76, -31.57 343.4, 32.07 81.26, -168.8 out-na out 12.0967 Saltbr-na 999.0 HRD-in -82.25, -60.3 91.76, -5.32 na-out-out SNCaoo out-out ActLoopNT-out 9.1429 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.85, -39.85 APE9-dihe-out -62.27, -26.85 APE8-dihe-out -86.04, 1.76 APE8-rot-na 292.25 APE67-dihe-out -100.68, 23.58 -62.84, 136.16 APE12-dist-na 9.712 APE11-dist-na 11.4338 APE10-dist-na 15.9334 APE9-dist-out 12.4277 W659A,W777A,F794H None None XRAY 1.5 0.182 0.208 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8b9h TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR KDR VGFR2_HUMAN 3VO3A P35968 812 1168 1356.0 0KF:2001 Type2 Inactive DFGout 16.4477 8.2146 None -125.16, 179.81 -141.05, 99.79 -70.03, -34.74 215.55, 55.41 59.77, -120.61 in-in in 7.3573 Saltbr-in 2.8979 HRD-in -84.45, -53.71 76.95, -3.4 in-out-in SNCioi out-in ActLoopNT-out 16.4768 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.91, 109.54 APE9-dihe-in -120.7, 147.5 APE8-dihe-in -78.09, 65.8 APE8-rot-na 32.33 APE67-dihe-in -67.73, -12.3 -53.4, -39.21 APE12-dist-na 17.0304 APE11-dist-na 14.0671 APE10-dist-na 11.3935 APE9-dist-in 7.9974 None None None XRAY 1.52 0.162 0.182 A 318.0 303.0 4 30 30 0 [[834, 1162]] 1.0 3vo3 TYR_KDR_HUMAN TYR 4.2e-100 340.3 1.0 260.0 260.0 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028.0 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
TYR KDR VGFR2_HUMAN 1YWNA P35968 820 1171 1356.0 LIF:60301 Type1 Inactive None 999.0 999.0 None -128.91, 171.96 -143.62, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 7.2102 Saltbr-in 2.725 HRD-in -77.88, -50.07 82.87, -17.6 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -141.39, 161.44 APE9-dihe-in -104.18, 100.32 APE8-dihe-out -56.09, -24.71 APE8-rot-na 336.02 APE67-dihe-in -70.59, -14.0 -51.58, -32.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.2392 E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 1.71 0.206 0.23 A 316.0 281.0 21 30 24 6 [[834, 1162]] 1.0 1ywn TYR_KDR_HUMAN TYR 4.1e-100 340.3 1.0 260.0 260.0 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028.0 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
TYR LCK LCK_HUMAN 2ZM1A P06239 231 501 509.0 KSF:513 Type1 Active DFGin 6.4993 14.1929 BLAminus -132.48, -160.42 31.13, 88.01 -99.25, 22.14 293.45, 97.67 -69.47, -32.89 in-in in 8.5119 Saltbr-in 2.9335 HRD-in -100.89, -51.07 73.44, -7.06 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.43, 148.33 APE9-dihe-in -138.82, 152.04 APE8-dihe-in -57.54, 117.05 APE8-rot-na 333.13 APE67-dihe-in -71.51, -24.6 -61.57, -39.74 APE12-dist-na 15.1006 APE11-dist-na 10.3495 APE10-dist-na 13.0138 APE9-dist-in 6.8223 None PTR394 PTR394 XRAY 2.1 0.172 0.232 A 285.0 271.0 0 29 29 0 [[245, 496]] 1.0 2zm1 TYR_LCK_HUMAN TYR 1.5e-94 322.1 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
TYR MERTK MERTK_HUMAN 9BHIA Q12866 578 864 999.0 A1APF:60901 Type1.5_Front Inactive DFGin 6.9923 12.8049 BLAminus -138.66, -158.87 44.96, 74.5 -90.39, 18.73 305.52, 137.7 -55.48, -30.3 out-out out 13.6153 Saltbr-out 13.031 HRD-in -81.75, -51.8 68.35, 6.62 out-in-out SNCoio in-out ActLoopNT-in 2.8195 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.15, 11.33 APE9-dihe-in -72.53, 150.77 APE8-dihe-in -64.75, 117.67 APE8-rot-na 25.92 APE67-dihe-in -73.91, -0.64 -53.67, -34.29 APE12-dist-na 7.154 APE11-dist-na 12.0556 APE10-dist-na 11.6569 APE9-dist-in 6.7096 None None None XRAY 2.07 0.211 0.23 A 323.0 278.0 9 30 28 2 [[587, 856]] 1.0 9bhi TYR_MERTK_HUMAN TYR 1.6e-92 315.5 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AB1A Q12866 571 862 999.0 C6F:60901 Type1 Inactive DFGin 5.8722 13.5268 None -150.27, 178.21 48.78, 48.66 -107.87, 999.0 41.9, 85.18 999.0, 999.0 out-out out 12.8443 Saltbr-out 9.5657 HRD-in -84.92, -52.07 85.67, -41.55 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 62.29 APE8-rot-na 36.31 APE67-dihe-in -65.53, -14.5 -57.08, -42.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.93 0.237 0.298 A 298.0 267.0 25 30 10 20 [[587, 856]] 1.0 7ab1 TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2.0 260.0 259.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MET MET_HUMAN 3ZCLA P08581 1052 1345 1390.0 5TF:1 Type1 Inactive DFGin 5.3407 14.0328 BLBplus -130.37, -159.34 48.43, 53.41 -147.61, 165.56 74.15, 92.01 59.61, -131.84 out-out out 14.6359 Saltbr-out 12.7854 HRD-in -76.45, -51.81 82.5, -13.86 out-out-in SNCooi out-in ActLoopNT-out 10.7346 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.5, 109.91 APE9-dihe-in -127.18, 152.9 APE8-dihe-in -78.54, 68.73 APE8-rot-na 30.54 APE67-dihe-in -82.79, -0.65 -60.11, -28.04 APE12-dist-na 22.9366 APE11-dist-na 18.1313 APE10-dist-na 17.7713 APE9-dist-in 7.3575 None None None XRAY 1.4 0.194 0.211 A 306.0 291.0 3 32 32 0 [[1078, 1339]] 1.0 3zcl TYR_MET_HUMAN TYR 6.7e-92 313.6 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 4MXCA P08581 1052 1346 1390.0 DWF:1401 Type2 Inactive DFGout 14.4103 10.3366 BBAminus -151.35, -174.18 -156.99, 122.43 -67.95, -16.78 287.52, 70.23 58.23, -116.98 in-in in 8.9293 Saltbr-in 3.5152 HRD-in -73.25, -51.06 80.68, -17.87 in-out-in SNCioi out-in ActLoopNT-out 15.2867 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -88.68, 108.68 APE9-dihe-in -118.71, 133.81 APE8-dihe-in -79.71, 72.93 APE8-rot-na 28.81 APE67-dihe-in -75.71, -5.79 -60.94, -31.89 APE12-dist-na 999.0 APE11-dist-na 13.6281 APE10-dist-na 10.2732 APE9-dist-in 7.344 None None None XRAY 1.632 0.18 0.207 A 319.0 290.0 5 32 27 5 [[1078, 1339]] 1.0 4mxc TYR_MET_HUMAN TYR 7.7e-92 313.7 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5H3QA P04629 484 796 796.0 7HF:1001 Type1 Inactive DFGout 12.7078 6.5827 BBAminus 172.54, 156.19 -157.42, 160.24 -99.39, 17.97 295.12, 97.4 79.34, 29.52 in-out in 9.4475 Saltbr-out 5.8508 HRD-in -81.9, -52.58 77.47, -12.71 out-out-in SNCooi out-in ActLoopNT-out 15.8006 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -128.94, 112.39 APE9-dihe-in -107.73, 133.13 APE8-dihe-in -79.15, 63.42 APE8-rot-na 34.45 APE67-dihe-in -63.33, -18.08 -61.61, -34.65 APE12-dist-na 13.7485 APE11-dist-na 15.1996 APE10-dist-na 10.6807 APE9-dist-in 7.568 None None None XRAY 2.1 0.19 0.215 A 324.0 303.0 10 30 30 0 [[510, 783]] 1.0 5h3q TYR_NTRK1_HUMAN TYR 2.4e-100 341.1 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5KMJA P04629 486 795 796.0 6UF:901 Type3 Inactive DFGout 12.074 7.6023 None 156.98, 152.76 -155.56, 161.93 -106.33, 28.22 308.11, 127.92 67.17, 26.59 in-in in 9.7145 Saltbr-in 2.7723 HRD-in -79.87, -55.53 78.72, -12.42 in-out-in SNCioi out-in ActLoopNT-out 16.1073 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.86, 120.05 APE9-dihe-in -107.69, 130.38 APE8-dihe-in -83.48, 63.94 APE8-rot-na 32.0 APE67-dihe-in -63.64, -21.11 -52.37, -37.83 APE12-dist-na 15.0163 APE11-dist-na 15.494 APE10-dist-na 11.0956 APE9-dist-in 7.6003 None None None XRAY 2.04 0.196 0.226 A 329.0 300.0 6 30 30 0 [[510, 783]] 1.0 5kmj TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR PTK2 FAK1_HUMAN 4EBWA Q05397 411 686 1052.0 0PF:700 Type1 Inactive DFGinter 10.5201 8.0228 None -156.77, 167.19 -119.55, 38.35 -154.8, 160.1 57.14, 97.67 -105.09, 155.15 in-in in 7.2322 Saltbr-in 3.0214 HRD-out -85.85, 108.83 -92.42, -13.42 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 105.2 APE9-dihe-in -103.42, 143.85 APE8-dihe-in -74.96, 72.04 APE8-rot-na 29.05 APE67-dihe-in -70.29, -24.24 -52.29, -39.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 17.857 APE9-dist-out 9.3907 None None None XRAY 2.65 0.186 0.273 A 304.0 259.0 17 29 14 15 [[422, 678]] 1.0 4ebw TYR_PTK2_HUMAN TYR 4.7e-93 317.2 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR SYK KSYK_HUMAN 5LMBA P43405 364 634 635.0 6ZF:701 Type1 Active DFGin 6.4476 14.2826 BLAminus -131.02, -173.87 62.28, 69.39 -93.16, 19.0 290.08, 82.25 -59.68, -28.46 in-in in 7.6957 Saltbr-in 2.454 HRD-in -78.06, -53.9 76.38, 4.89 in-in-in SNCiii in-in ActLoopNT-in 2.9631 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.66, 104.96 APE9-dihe-in -108.73, 152.4 APE8-dihe-in -79.7, 70.25 APE8-rot-na 31.84 APE67-dihe-in -69.34, -16.13 -51.43, -34.69 APE12-dist-na 13.0735 APE11-dist-na 10.546 APE10-dist-na 11.4482 APE9-dist-in 6.9588 None PTR525 PTR525 XRAY 1.95 0.178 0.228 A 277.0 265.0 6 31 31 0 [[370, 628]] 1.0 5lmb TYR_SYK_HUMAN TYR 4.6e-90 307.4 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 5LMBB P43405 364 630 635.0 6ZF:701 Type1 None DFGin 6.5417 14.2074 BLAminus -133.05, -174.7 62.98, 72.21 -97.02, 21.38 290.54, 88.36 -62.52, -32.46 in-in in 7.7365 Saltbr-in 2.5556 HRD-in -77.26, -52.74 74.6, 8.57 in-in-none SNCiin in-none ActLoopNT-in 2.872 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.43 APE8-dihe-in -80.7, 73.18 APE8-rot-na 30.16 APE67-dihe-in -64.42, -18.25 -49.18, -37.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.9476 None PTR525 PTR525 XRAY 1.95 0.178 0.228 B 277.0 262.0 5 31 26 5 [[370, 628]] 1.0 5lmb TYR_SYK_HUMAN TYR 4.6e-90 307.4 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4YJOA P43405 363 632 635.0 4DF:701 Type1 Active DFGin 7.1511 15.4037 BLAminus -136.57, 178.57 59.58, 80.7 -95.16, 22.65 286.36, 75.19 -55.96, -31.16 in-in in 8.3198 Saltbr-in 3.0437 HRD-in -80.48, -52.4 72.29, 6.84 in-in-in SNCiii in-in ActLoopNT-in 2.9567 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -56.5, 127.44 APE9-dihe-in -144.08, 83.31 APE8-dihe-in -75.74, 70.97 APE8-rot-na 33.07 APE67-dihe-in -63.43, -16.56 -52.99, -37.5 APE12-dist-na 999.0 APE11-dist-na 10.63 APE10-dist-na 7.9003 APE9-dist-in 7.5071 None None None XRAY 1.6 0.186 0.23 A 281.0 267.0 3 31 28 3 [[370, 628]] 1.0 4yjo TYR_SYK_HUMAN TYR 4.8e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 5TT7A P43405 358 635 635.0 7KF:60901 Type1 Active DFGin 6.3107 14.3414 BLAminus -130.62, -177.29 62.11, 72.82 -94.96, 21.67 289.95, 80.8 -60.6, -26.94 in-in in 7.7094 Saltbr-in 2.8404 HRD-in -77.7, -52.28 69.96, 13.2 in-in-in SNCiii in-in ActLoopNT-in 2.8781 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.65, 88.09 APE9-dihe-in -107.14, 140.48 APE8-dihe-in -78.3, 78.38 APE8-rot-na 32.04 APE67-dihe-in -64.56, -15.37 -56.64, -35.35 APE12-dist-na 13.888 APE11-dist-na 10.557 APE10-dist-na 10.3425 APE9-dist-in 6.8486 None None None XRAY 1.77 0.208 0.234 A 289.0 270.0 8 31 31 0 [[370, 628]] 1.0 5tt7 TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4FYOA P43405 363 635 635.0 0VF:60701 Type1 None DFGin 6.5272 14.6759 BLAminus -132.65, -177.95 62.23, 72.42 -93.99, 21.12 289.45, 90.18 -61.07, -25.58 in-in in 7.7502 Saltbr-in 2.757 HRD-in -74.26, -50.97 72.76, 4.05 in-in-none SNCiin in-none ActLoopNT-in 2.9524 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 140.05 APE9-dihe-in -108.11, 144.2 APE8-dihe-in -76.07, 73.27 APE8-rot-na 27.85 APE67-dihe-in -65.29, -14.44 -52.41, -38.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.9467 APE9-dist-in 7.3079 None None None XRAY 1.4 0.22 0.24 A 291.0 263.0 10 31 27 4 [[370, 628]] 1.0 4fyo TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4GFGA P43405 363 635 635.0 0XF:60701 Type1 Active DFGin 6.3816 14.7063 BLAminus -133.41, -165.6 61.44, 68.78 -94.44, 29.51 290.84, 74.86 -64.09, -30.1 in-in in 8.5511 Saltbr-in 3.4972 HRD-in -86.12, -47.8 68.36, 5.25 in-in-in SNCiii in-in ActLoopNT-in 2.8664 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -53.12, 138.6 APE9-dihe-in -110.15, 137.21 APE8-dihe-in -65.63, 68.92 APE8-rot-na 25.72 APE67-dihe-in -68.08, -17.47 -52.98, -35.53 APE12-dist-na 9.5817 APE11-dist-na 10.6292 APE10-dist-na 11.7062 APE9-dist-in 7.231 None None None XRAY 2.35 0.221 0.246 A 291.0 273.0 0 31 31 0 [[370, 628]] 1.0 4gfg TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK

Ligand: F

Total number of chains: 181
Active chains: 40
Total number of genes: 65
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 86 47.5% 4AW0A
DFGin ABAminus 22 12.2% 7PIEA
DFGin BLAplus 19 10.5% 9UHIA
DFGin None 16 8.8% 8B9EA
DFGin BLBplus 10 5.5% 3ZCLA
DFGout BBAminus 10 5.5% 4MXCA
DFGout None 9 5.0% 3VO3A
DFGin BLBminus 4 2.2% 5R9OA
DFGin BLBtrans 2 1.1% 2R3IA
None None 2 1.1% 5IEXA
DFGinter None 1 0.6% 4EBWA

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC PRKACA KAPCA_CRIGR 7PIEA P25321 1 351 351.0 7QF:60401 Type1 Inactive DFGin 6.4369 14.7079 ABAminus -120.2, -32.0 -97.5, 116.46 -117.79, 21.67 284.38, 87.37 -67.96, -24.99 in-in in 9.0175 Saltbr-in 2.947 HRD-in -90.08, -55.75 70.92, 8.29 in-in-in SNCiii in-in ActLoopNT-in 2.9298 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.9, 155.75 APE9-dihe-na 129.48, -166.45 APE8-dihe-in -116.19, 135.64 APE8-rot-in 298.32 APE67-dihe-in -59.08, -26.0 -47.12, -51.73 APE12-dist-in 8.298 APE11-dist-in 11.4827 APE10-dist-in 5.9206 APE9-dist-in 3.8942 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.427 0.137 0.158 A 353.0 350.0 0 25 25 0 [[44, 298]] 1.0 7pie Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 9RETA P25321 13 351 351.0 A1JEF:60404 Allosteric Active DFGin 6.5025 14.9192 BLAminus -121.64, 161.02 79.66, 89.44 -97.28, 25.84 271.42, 57.67 -59.32, -29.98 in-in in 9.0584 Saltbr-in 2.6884 HRD-in -91.57, -50.28 65.7, 14.34 in-in-in SNCiii in-in ActLoopNT-in 2.9609 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.82, 155.57 APE9-dihe-na 119.38, 155.92 APE8-dihe-in -73.83, 138.5 APE8-rot-in 315.72 APE67-dihe-in -57.32, -25.4 -54.39, -42.36 APE12-dist-in 8.1859 APE11-dist-in 11.4021 APE10-dist-in 5.9522 APE9-dist-in 4.2407 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.75 0.193 0.227 A 353.0 339.0 0 25 25 0 [[44, 298]] 1.0 9ret Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
TYR SRC SRC_CHICK 5SYSA P00523 258 533 533.0 72F:600 Type2 Inactive DFGout 13.3536 9.8008 BBAminus -126.48, -173.83 -168.38, 115.62 -104.78, -47.96 311.28, 146.33 163.56, 999.0 in-in in 8.5789 Saltbr-in 3.0301 HRD-in -86.37, -44.08 72.1, 11.73 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -16.31 APE8-rot-na 5.39 APE67-dihe-in -61.6, -39.03 -88.61, -20.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V281C None None XRAY 2.8 0.288 0.334 A 286.0 258.0 18 29 11 18 [[267, 518]] 1.0 5sys Gallus gallus TYR_SRC_CHICK TYR 4.2e-93 317.3 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 5SYSB P00523 258 533 533.0 72F:600 Type2 Inactive DFGout 13.4129 10.163 BBAminus -126.31, -175.1 -166.31, 115.77 -103.34, -47.57 306.63, 130.98 67.96, 999.0 in-in in 8.3206 Saltbr-in 3.0439 HRD-in -86.54, -44.23 72.2, 11.45 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -18.84 APE8-rot-na 6.43 APE67-dihe-in -61.0, -39.73 -89.58, -19.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V281C None None XRAY 2.8 0.288 0.334 B 286.0 258.0 18 29 11 18 [[267, 518]] 1.0 5sys Gallus gallus TYR_SRC_CHICK TYR 4.2e-93 317.3 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
AGC AKT1 AKT1_HUMAN 4EKLA P31749 144 478 480.0 0RF:501 Type1 Active DFGin 6.4963 13.4232 BLAminus -130.08, 156.46 77.16, 99.77 -112.66, 14.16 298.65, 90.33 -61.32, -30.96 in-in in 8.9582 Saltbr-in 2.4524 HRD-in -78.38, -44.96 68.93, -13.6 in-in-in SNCiii in-in ActLoopNT-in 2.7571 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.83, 160.76 APE9-dihe-na 116.71, 166.32 APE8-dihe-in -83.66, 133.51 APE8-rot-in 293.53 APE67-dihe-in -68.09, -18.95 -43.13, -46.31 APE12-dist-in 8.36 APE11-dist-in 11.5119 APE10-dist-in 6.0113 APE9-dist-in 4.4431 S473D TPO308 TPO308 XRAY 2.0 0.175 0.235 A 341.0 330.0 0 28 28 0 [[150, 408]] 1.0 4ekl Homo sapiens AGC_AKT1_HUMAN AGC 2.3e-99 337.7 1.0 260.0 260.0 291 292 293 295 297 179 198 202 271 273 272 274.0 331 319 314 313 312 311 310 309 308 228 RAC-alpha serine/threonine-protein kinase
AGC GRK5 GRK5_HUMAN 9BRPA P34947 25 542 590.0 A1ARF:601 Type1 Inactive DFGin 6.2535 12.4795 ABAminus -116.3, -61.02 -91.04, 101.81 -97.25, 10.66 289.92, 84.11 -59.57, -18.7 in-in in 8.9098 Saltbr-in 3.0371 HRD-in -85.07, -56.86 71.89, 13.22 in-in-in SNCiii in-in ActLoopNT-in 3.1048 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.18, 177.63 APE9-dihe-na 122.23, -155.28 APE8-dihe-in -122.73, 136.27 APE8-rot-in 286.0 APE67-dihe-inflip 100.9, -21.88 -54.82, 128.22 APE12-dist-in 9.574 APE11-dist-in 11.9322 APE10-dist-in 6.253 APE9-dist-in 4.143 D311N None None XRAY 2.8 0.245 0.283 A 598.0 502.0 0 27 27 0 [[186, 448]] 1.0 9brp Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9BREA P34947 25 542 590.0 W3F:601 Type1 Active DFGin 6.1758 12.5641 BLAminus -128.67, 172.15 57.35, 77.75 -93.22, 24.8 286.17, 72.14 -63.15, -21.99 in-in in 8.8006 Saltbr-in 2.4578 HRD-in -88.2, -51.09 67.29, 13.94 in-in-in SNCiii in-in ActLoopNT-in 3.1273 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.49, 165.19 APE9-dihe-na 125.58, -150.88 APE8-dihe-in -124.55, 138.39 APE8-rot-in 312.36 APE67-dihe-inflip 92.11, -16.19 -53.44, 132.83 APE12-dist-in 9.9432 APE11-dist-in 12.1314 APE10-dist-in 6.3367 APE9-dist-in 4.1222 D311N None None XRAY 2.8 0.215 0.26 A 598.0 503.0 0 27 27 0 [[186, 448]] 1.0 9bre Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 8UAQA P34947 25 542 590.0 W3F:601 Type1 Inactive DFGin 6.0198 12.8412 None -112.48, -65.82 -86.97, 96.33 -93.06, 17.75 286.66, 70.13 -64.2, -19.76 in-in in 9.3335 Saltbr-in 3.3688 HRD-in -90.24, -57.5 70.99, -0.54 in-in-in SNCiii in-in ActLoopNT-in 3.0372 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.56, 170.13 APE9-dihe-na 119.68, -157.85 APE8-dihe-in -112.7, 143.6 APE8-rot-in 314.4 APE67-dihe-inflip 89.64, -4.73 -59.54, 131.81 APE12-dist-in 9.916 APE11-dist-in 12.1019 APE10-dist-in 6.3064 APE9-dist-in 4.1737 D311N None None XRAY 2.8 0.232 0.277 A 598.0 501.0 0 27 27 0 [[186, 448]] 1.0 8uaq Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC PDPK1 PDPK1_HUMAN 4AW0A O15530 75 359 556.0 ATP:500,MJF:600 ATPlike,Allosteric Active DFGin 6.5313 14.9926 BLAminus -134.84, 177.25 78.73, 76.19 -106.3, 8.53 283.51, 97.11 -69.63, -19.36 in-in in 8.5954 Saltbr-in 3.0091 HRD-in -83.05, -53.03 79.45, -12.94 in-in-in SNCiii in-in ActLoopNT-in 2.9336 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.69, 159.04 APE9-dihe-na 139.48, -167.8 APE8-dihe-in -131.87, 132.42 APE8-rot-in 295.45 APE67-dihe-in -61.29, -25.28 -54.74, -42.17 APE12-dist-in 7.5089 APE11-dist-in 10.6011 APE10-dist-in 5.0264 APE9-dist-in 3.5797 Y288G,Q292A SEP241 SEP241,CME260 XRAY 1.43 0.171 0.188 A 311.0 285.0 0 30 30 0 [[82, 342]] 1.0 4aw0 Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PRKCH KPCL_HUMAN 8FP1A P24723 349 676 683.0 XXF:9000 Type1 Active DFGin 6.0402 12.8612 BLAminus -134.17, 160.39 76.6, 103.68 -113.44, 14.82 306.37, 103.97 -62.81, -37.48 in-in in 8.5287 Saltbr-in 2.747 HRD-in -71.28, -48.4 60.66, 8.21 in-in-in SNCiii in-in ActLoopNT-in 3.0416 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -168.52, 169.89 APE9-dihe-na 121.68, 166.05 APE8-dihe-in -83.39, 128.15 APE8-rot-in 297.95 APE67-dihe-in -61.25, -27.98 -43.8, -44.17 APE12-dist-in 8.6657 APE11-dist-in 11.7009 APE10-dist-in 6.3651 APE9-dist-in 3.5655 S675E TPO513,TPO656 TPO513,TPO656 XRAY 1.85 0.2 0.234 A 353.0 328.0 0 28 28 0 [[355, 614]] 1.0 8fp1 Homo sapiens AGC_PRKCH_HUMAN AGC 1.6e-97 331.6 1.0 260.0 260.0 496 497 498 500 502 384 403 407 476 478 477 479.0 536 524 519 518 517 516 515 514 513 434 Protein kinase C eta type
CAMK AURKA AURKA_HUMAN 8C1DA O14965 127 388 403.0 T2F:401,ADP:402,T5L:405 Allosteric,ATPlike,Allosteric Inactive DFGin 5.5903 14.7701 BLAminus -129.39, 179.64 57.3, 80.97 -92.88, 23.53 280.13, 79.47 -56.16, -33.44 in-in in 9.3061 Saltbr-in 2.9364 HRD-in -72.1, -50.49 67.69, -1.24 in-in-out SNCiio in-out ActLoopNT-in 2.7964 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 144.85 APE8-dihe-in -64.26, 154.27 APE8-rot-out 88.6 APE67-dihe-in -39.49, -36.75 -82.32, -6.09 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.088 C290A None None XRAY 2.115 0.212 0.238 A 265.0 259.0 3 26 23 3 [[133, 383]] 1.0 8c1d Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-79 270.6 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2W1FA O14965 127 389 403.0 L0F:61390 Type1 Inactive DFGin 5.6549 15.7027 BLAminus -96.26, 172.45 62.06, 107.69 -118.91, 38.89 289.12, 66.42 -59.62, -48.4 out-out out 10.1385 Saltbr-out 5.1197 HRD-in -78.79, -54.88 78.03, -25.41 out-in-out SNCoio in-out ActLoopNT-in 2.6762 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -157.03 APE8-dihe-in -58.47, 105.92 APE8-rot-out 190.33 APE67-dihe-in -42.4, -27.58 -64.36, -20.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.7745 None None None XRAY 2.85 0.246 0.348 A 275.0 253.0 10 26 16 10 [[133, 383]] 1.0 2w1f Homo sapiens CAMK_AURKA_HUMAN CAMK 6.7e-80 274.0 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3O51A O14965 126 388 403.0 LJF:1 Type1.5_Front Inactive DFGout 12.9209 9.2148 None -125.94, 46.56 -78.14, 156.47 -164.09, 999.0 59.42, 112.33 999.0, 999.0 out-none out 12.8625 Saltbr-none 999.0 HRD-out -126.02, 153.87 -92.88, -115.51 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -57.91, -10.7 999.0, -51.84 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.288 0.304 A 267.0 246.0 17 26 9 17 [[133, 383]] 1.0 3o51 Homo sapiens CAMK_AURKA_HUMAN CAMK 6e-80 274.2 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK CAMK2A KCC2A_HUMAN 2VZ6A Q9UQM7 9 299 478.0 FEF:60600 Type1 Active DFGin 7.1238 13.9304 BLAminus -130.3, 144.9 77.59, 104.3 -118.45, 37.91 281.19, 70.53 -60.86, -31.43 in-in in 9.0324 Saltbr-in 2.6227 HRD-in -71.43, -45.76 75.34, -9.9 in-in-in SNCiii in-in ActLoopNT-in 2.8051 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.76, 148.02 APE9-dihe-na 132.07, -168.34 APE8-dihe-in -120.79, 126.49 APE8-rot-in 299.71 APE67-dihe-in -63.07, -18.83 -35.01, -58.7 APE12-dist-in 10.327 APE11-dist-in 11.8194 APE10-dist-in 5.9929 APE9-dist-in 3.8322 None None None XRAY 2.3 0.165 0.203 A 313.0 289.0 2 28 28 0 [[13, 271]] 1.0 2vz6 Homo sapiens CAMK_CAMK2A_HUMAN CAMK 1.6e-96 328.7 1.0 256.0 256.0 155 156 157 159 161 42 60 64 132 134 133 135.0 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 2VZ6B Q9UQM7 9 300 478.0 FEF:60600 Type1 Active DFGin 6.8653 14.0317 BLAminus -131.92, 139.26 77.54, 110.88 -122.08, 32.95 286.68, 71.96 -61.55, -26.54 in-in in 9.3105 Saltbr-in 2.9307 HRD-in -73.12, -44.65 73.93, -20.22 in-in-in SNCiii in-in ActLoopNT-in 2.8744 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.21, 149.78 APE9-dihe-na 143.11, -171.05 APE8-dihe-in -118.3, 128.44 APE8-rot-in 303.95 APE67-dihe-in -66.72, -18.78 -39.97, -52.82 APE12-dist-in 10.2519 APE11-dist-in 11.7563 APE10-dist-in 5.9962 APE9-dist-in 3.963 None None None XRAY 2.3 0.165 0.203 B 313.0 292.0 0 28 28 0 [[13, 271]] 1.0 2vz6 Homo sapiens CAMK_CAMK2A_HUMAN CAMK 1.6e-96 328.7 1.0 256.0 256.0 155 156 157 159 161 42 60 64 132 134 133 135.0 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CHEK1 CHK1_HUMAN 8E80A O14757 8 271 476.0 UUF:301 Type1 Active DFGin 6.9481 13.5611 BLAminus -116.38, 163.51 69.37, 105.0 -111.89, 20.17 292.16, 81.73 -65.53, -30.68 in-in in 8.5794 Saltbr-in 2.859 HRD-in -73.57, -45.75 72.69, 0.21 in-in-in SNCiii in-in ActLoopNT-in 2.9485 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.33, 170.54 APE9-dihe-na 117.83, -149.18 APE8-dihe-in -134.92, 121.74 APE8-rot-in 303.05 APE67-dihe-in -62.91, -20.27 -44.12, -51.23 APE12-dist-in 9.3649 APE11-dist-in 11.6442 APE10-dist-in 6.1424 APE9-dist-in 3.4974 N59L,V68I,L84M,Y86L,C87A,E91S,E134H,S147A,F149Y,G150S None None XRAY 1.49 0.209 0.242 A 297.0 258.0 6 30 30 0 [[9, 265]] 1.0 8e80 Homo sapiens CAMK_CHEK1_HUMAN CAMK 4.8e-69 238.4 2.0 256.0 255.0 147 148 149 151 153 38 55 59 127 129 128 130.0 190 177 172 171 170 169 168 167 166 85 Serine/threonine-protein kinase Chk1
CAMK CHEK2 CHK2_HUMAN 2YCFA O96017 210 510 543.0 YCF:600 Type1 Inactive DFGin 6.6505 14.4245 BLAminus -133.14, 179.08 68.92, 89.26 -105.02, 26.49 290.18, 77.38 -65.99, -23.19 in-out in 9.994 Saltbr-out 8.5603 HRD-in -70.72, -52.98 75.15, -0.9 out-in-out SNCoio in-out ActLoopNT-in 2.9054 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -72.28, -26.54 APE9-dihe-na -96.81, -179.54 APE8-dihe-in -85.38, 132.85 APE8-rot-in 297.44 APE67-dihe-in -44.53, -40.92 -82.1, 28.65 APE12-dist-out 25.2308 APE11-dist-out 27.2893 APE10-dist-out 29.3634 APE9-dist-out 33.1045 None None None XRAY 1.77 0.197 0.218 A 322.0 286.0 15 27 27 0 [[220, 486]] 1.0 2ycf Homo sapiens CAMK_CHEK2_HUMAN CAMK 2e-85 292.2 1.0 256.0 256.0 367 368 369 371 373 249 273 277 344 346 345 347.0 409 394 389 388 387 386 385 384 383 302 Serine/threonine-protein kinase Chk2
CAMK DAPK1 DAPK1_HUMAN 6AARA P53355 2 277 1430.0 9TF:300 Type1 Inactive DFGin 6.7434 14.3416 BLAminus -121.31, 178.32 64.29, 78.62 -87.38, 15.28 286.92, 75.84 -59.31, -26.74 in-in in 9.3863 Saltbr-in 2.8106 HRD-in -76.03, -46.41 70.92, -12.19 in-in-out SNCiio in-out ActLoopNT-in 2.9205 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -137.91, 116.13 APE9-dihe-na -97.58, -145.9 APE8-dihe-in -81.4, 124.5 APE8-rot-in 302.0 APE67-dihe-in -55.21, -31.9 -47.73, -42.04 APE12-dist-in 11.0192 APE11-dist-out 6.2597 APE10-dist-out 9.242 APE9-dist-in 4.8049 None None None XRAY 1.95 0.182 0.22 A 293.0 269.0 7 27 27 0 [[13, 275]] 1.0 6aar Homo sapiens CAMK_DAPK1_HUMAN CAMK 6.1e-95 323.3 1.0 256.0 256.0 160 161 162 164 166 42 64 68 136 138 137 139.0 199 187 182 181 180 179 178 177 176 94 Death-associated protein kinase 1
CAMK MAPKAPK2 MAPK2_HUMAN 3M42A P49137 47 364 400.0 HGF:365 Type1 None DFGin 4.2648 13.7652 BLAminus -127.28, 170.7 71.87, 101.44 -103.87, 20.75 277.01, 69.5 -61.92, -8.22 in-in in 9.2598 Saltbr-in 3.0911 HRD-in -73.72, -58.45 76.25, 11.76 in-in-none SNCiin in-none ActLoopNT-in 2.9117 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 P237G None None XRAY 2.68 0.186 0.232 A 299.0 290.0 7 -206 -206 0 [[63, 325]] 1.0 3m42 Homo sapiens CAMK_MAPKAPK2_HUMAN CAMK 1.9e-36 228.6 3.0 154.0 236.0 206 207 208 210 212 93 104 108 183 185 184 186.0 245 0 0 0 0 0 0 0 0 139 MAP kinase-activated protein kinase 2
CAMK MELK MELK_HUMAN 5IH9A Q14680 3 327 651.0 6BF:60401 Type1 None DFGin 6.9392 15.1461 BLAminus -123.48, 176.08 58.26, 79.91 -95.72, 21.84 280.98, 78.3 -67.92, -25.97 in-in in 8.7195 Saltbr-in 2.5866 HRD-in -71.83, -48.59 72.02, -0.04 in-in-none SNCiin in-none ActLoopNT-in 2.9916 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -4.81 APE8-rot-in 291.01 APE67-dihe-in -55.95, -27.86 -55.75, -43.81 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.79 0.174 0.2 A 335.0 307.0 18 29 15 14 [[11, 263]] 1.0 5ih9 Homo sapiens CAMK_MELK_HUMAN CAMK 9.7e-89 303.1 1.0 256.0 256.0 149 150 151 153 155 40 57 61 129 131 130 132.0 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK PIM1 PIM1_HUMAN 5KGIA P11309 33 305 313.0 6SF:414 Type1 Active DFGin 6.1959 14.6781 BLAminus -128.85, 173.72 58.37, 80.83 -91.15, 15.65 283.15, 78.86 -67.29, -15.19 in-in in 8.8975 Saltbr-in 2.6991 HRD-naA -66.85, -48.52 69.49, 3.32 in-in-in SNCiii in-in ActLoopNT-in 2.8537 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.48, 30.3 APE9-dihe-na -88.67, -155.26 APE8-dihe-in -89.24, 121.14 APE8-rot-in 310.96 APE67-dihe-in -66.24, -12.88 -55.29, -44.34 APE12-dist-in 9.7233 APE11-dist-in 8.7346 APE10-dist-in 5.6424 APE9-dist-in 3.7397 None None None XRAY 2.13 0.173 0.186 A 276.0 273.0 0 26 26 0 [[38, 290]] 1.0 5kgi Homo sapiens CAMK_PIM1_HUMAN CAMK 2.5e-65 226.2 1.0 256.0 256.0 185 186 187 189 191 67 89 93 164 166 165 167.0 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 6L13A P11309 33 305 313.0 E2F:401 Type1 Active DFGin 6.1902 14.7858 BLAminus -130.24, 168.2 68.46, 80.68 -89.17, 16.05 288.1, 80.31 -69.01, -19.61 in-in in 9.1055 Saltbr-in 2.9362 HRD-naA -68.46, -51.8 71.9, 8.52 in-in-in SNCiii in-in ActLoopNT-in 2.7778 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.76, 29.56 APE9-dihe-na -92.34, -153.25 APE8-dihe-in -98.43, 124.2 APE8-rot-in 303.55 APE67-dihe-in -68.48, -12.49 -58.68, -45.06 APE12-dist-in 9.5 APE11-dist-in 8.5109 APE10-dist-in 5.0987 APE9-dist-in 3.6586 None SEP261 SEP261 XRAY 2.24 0.18 0.214 A 289.0 273.0 0 26 26 0 [[38, 290]] 1.0 6l13 Homo sapiens CAMK_PIM1_HUMAN CAMK 3e-65 226.0 1.0 256.0 256.0 185 186 187 189 191 67 89 93 164 166 165 167.0 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 2O65A P11309 33 306 313.0 MYF:501 Type1 Active DFGin 5.7731 14.2228 BLAminus -134.9, 170.04 60.08, 89.22 -101.35, 10.62 287.34, 92.73 -63.96, -9.9 in-in in 8.7039 Saltbr-in 2.4715 HRD-naA -65.14, -47.59 70.03, -4.07 in-in-in SNCiii in-in ActLoopNT-in 2.9803 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.66, 34.64 APE9-dihe-na -104.35, -148.26 APE8-dihe-in -83.11, 121.1 APE8-rot-in 316.59 APE67-dihe-in -62.15, -16.44 -57.04, -47.52 APE12-dist-in 9.9881 APE11-dist-in 8.6279 APE10-dist-in 5.2887 APE9-dist-in 4.1355 None None None XRAY 2.85 0.21 0.262 A 293.0 274.0 0 26 26 0 [[38, 290]] 1.0 2o65 Homo sapiens CAMK_PIM1_HUMAN CAMK 3.2e-65 226.0 1.0 256.0 256.0 185 186 187 189 191 67 89 93 164 166 165 167.0 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 8R0WA P11309 33 305 313.0 XGF:405 Type1 Active DFGin 5.9965 14.3841 BLAminus -131.73, 166.77 65.97, 82.46 -89.79, 16.41 289.35, 79.56 -63.02, -16.4 in-in in 8.8117 Saltbr-in 2.6426 HRD-naA -73.15, -45.35 65.43, 10.88 in-in-in SNCiii in-in ActLoopNT-in 2.8554 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.23, 17.26 APE9-dihe-na -81.93, -156.28 APE8-dihe-in -91.39, 121.88 APE8-rot-in 296.84 APE67-dihe-in -71.92, -8.94 -64.52, -38.27 APE12-dist-in 9.5591 APE11-dist-in 8.4794 APE10-dist-in 5.1163 APE9-dist-in 3.7129 R250G SEP261 SEP261 XRAY 1.95 0.167 0.201 A 313.0 273.0 0 26 26 0 [[38, 290]] 1.0 8r0w Homo sapiens CAMK_PIM1_HUMAN CAMK 1.5e-64 223.7 1.0 256.0 256.0 185 186 187 189 191 67 89 93 164 166 165 167.0 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CAMK PIM1 PIM1_HUMAN 8AFRA P11309 33 305 313.0 M0F:401 Type1 Active DFGin 6.0243 14.4056 BLAminus -126.46, 177.16 55.61, 83.44 -89.48, 19.88 284.93, 74.96 -67.33, -13.52 in-in in 8.8307 Saltbr-in 2.6484 HRD-naA -72.52, -48.51 66.56, 10.77 in-in-in SNCiii in-in ActLoopNT-in 2.8149 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.4, 19.87 APE9-dihe-na -78.39, -149.93 APE8-dihe-in -97.85, 123.61 APE8-rot-in 301.25 APE67-dihe-in -68.16, -10.25 -64.9, -40.75 APE12-dist-in 9.7271 APE11-dist-in 8.4666 APE10-dist-in 5.304 APE9-dist-in 3.645 R250G SEP261 SEP261 XRAY 2.15 0.166 0.191 A 309.0 264.0 7 26 26 0 [[38, 290]] 1.0 8afr Homo sapiens CAMK_PIM1_HUMAN CAMK 3.1e-62 216.2 1.0 256.0 256.0 185 186 187 189 191 67 89 93 164 166 165 167.0 224 211 206 205 204 203 202 201 200 121 Serine/threonine-protein kinase pim-1
CMGC CDK12 CDK12_HUMAN 8BU5B Q9NYV4 713 1044 1490.0 RMF:1101 Type1 Inactive DFGin 6.8015 14.7007 ABAminus -126.95, -66.04 -93.95, 105.24 -102.41, 30.18 293.69, 100.66 -84.84, -22.58 in-out in 8.3047 Saltbr-out 3.9335 HRD-out -78.59, 106.12 -94.17, 5.74 out-in-out SNCoio in-out ActLoopNT-in 2.8278 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -136.91, -22.25 APE9-dihe-na -109.89, 157.52 APE8-dihe-in -56.01, 131.78 APE8-rot-in 308.02 APE67-dihe-in -60.99, -26.61 -52.03, -40.26 APE12-dist-out 14.2801 APE11-dist-in 11.9408 APE10-dist-in 7.3604 APE9-dist-in 3.7666 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 B 344.0 332.0 0 29 29 0 [[727, 1020]] 1.0 8bu5 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU5H Q9NYV4 713 1043 1490.0 RMF:1101 Type1 Inactive DFGin 7.0152 14.9781 ABAminus -128.46, -54.53 -90.71, 103.12 -97.22, 31.8 290.43, 81.59 -85.33, -25.69 in-in in 8.4795 Saltbr-in 3.5275 HRD-in -73.55, -49.58 63.85, -4.76 in-in-in SNCiii in-in ActLoopNT-in 2.6292 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.5, -28.02 APE9-dihe-na -97.36, 153.71 APE8-dihe-in -57.72, 135.61 APE8-rot-in 311.07 APE67-dihe-in -63.38, -27.52 -50.57, -39.59 APE12-dist-in 13.9415 APE11-dist-in 12.128 APE10-dist-in 7.2577 APE9-dist-in 3.4973 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 H 344.0 331.0 0 29 29 0 [[727, 1020]] 1.0 8bu5 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUNB Q9NYV4 715 1041 1490.0 RNF:61101 Type1 Inactive DFGin 7.0092 15.2967 ABAminus -131.36, -49.43 -89.83, 91.44 -92.44, 32.63 287.3, 77.5 -75.27, -18.22 in-in in 7.7476 Saltbr-in 3.2793 HRD-in -75.67, -53.71 75.4, -0.11 in-in-in SNCiii in-in ActLoopNT-in 2.9232 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -107.12, -39.12 APE9-dihe-na -104.98, 151.97 APE8-dihe-in -58.93, 142.91 APE8-rot-in 279.94 APE67-dihe-in -65.42, -33.6 -55.06, -35.14 APE12-dist-in 13.3877 APE11-dist-in 11.6951 APE10-dist-in 7.099 APE9-dist-in 3.6569 K965R TPO893 TPO893 XRAY 3.08 0.187 0.211 B 344.0 327.0 0 29 29 0 [[727, 1020]] 1.0 8bun Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUNH Q9NYV4 715 1043 1490.0 RNF:61101 Type1 Inactive DFGin 7.0453 15.2864 ABAminus -125.24, -50.09 -100.69, 94.75 -92.24, 30.97 286.18, 71.82 -75.42, -18.26 in-in in 7.8338 Saltbr-in 3.3735 HRD-in -77.6, -54.36 73.0, -1.25 in-in-in SNCiii in-in ActLoopNT-in 2.74 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -108.56, -41.65 APE9-dihe-na -95.79, 153.05 APE8-dihe-in -58.87, 144.43 APE8-rot-in 305.25 APE67-dihe-in -65.98, -31.29 -55.83, -37.71 APE12-dist-in 13.7752 APE11-dist-in 11.9719 APE10-dist-in 6.9568 APE9-dist-in 3.4785 K965R TPO893 TPO893 XRAY 3.08 0.187 0.211 H 344.0 329.0 0 29 29 0 [[727, 1020]] 1.0 8bun Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 9FMRE Q9NYV4 714 1042 1490.0 RMF:61101 Type1 Inactive DFGin 6.7935 14.6403 ABAminus -113.83, -79.52 -84.15, 118.47 -115.27, 16.16 293.54, 100.02 -64.02, -34.33 in-out in 9.6335 Saltbr-out 3.6123 HRD-out -79.17, 82.22 -59.96, 8.89 out-in-out SNCoio in-out ActLoopNT-in 3.0256 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -148.14, -27.51 APE9-dihe-na -104.44, 148.12 APE8-dihe-in -51.45, 137.55 APE8-rot-in 306.02 APE67-dihe-in -70.5, -21.3 -54.61, -36.19 APE12-dist-out 14.2984 APE11-dist-in 12.2112 APE10-dist-in 7.469 APE9-dist-in 3.7666 None TPO893 TPO893 XRAY 3.9 0.209 0.25 E 351.0 329.0 0 29 29 0 [[727, 1020]] 1.0 9fmr Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 9FMRH Q9NYV4 714 1044 1490.0 RMF:61101 Type1 Inactive DFGin 6.8012 14.6033 ABAminus -113.95, -78.4 -84.85, 124.02 -118.87, 17.95 291.29, 89.7 -63.88, -35.4 in-in in 8.5917 Saltbr-in 3.5517 HRD-in -72.47, -40.65 59.82, 5.57 in-in-in SNCiii in-in ActLoopNT-in 2.9439 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -147.74, -27.71 APE9-dihe-na -103.25, 148.34 APE8-dihe-in -51.07, 136.63 APE8-rot-in 306.14 APE67-dihe-in -69.99, -21.15 -54.39, -34.8 APE12-dist-in 13.8232 APE11-dist-in 12.0979 APE10-dist-in 7.2545 APE9-dist-in 3.6076 None TPO893 TPO893 XRAY 3.9 0.209 0.25 H 351.0 331.0 0 29 29 0 [[727, 1020]] 1.0 9fmr Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BUNE Q9NYV4 715 1039 1490.0 RNF:61101 Type1 Inactive DFGin 7.2173 15.3129 BLAminus -143.55, -179.06 50.55, 77.42 -92.12, 34.85 285.27, 76.47 -72.26, -18.51 in-in in 7.8237 Saltbr-in 3.0461 HRD-in -77.13, -53.65 75.0, -0.22 in-in-out SNCiio in-out ActLoopNT-in 2.9239 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -105.31, -34.23 APE9-dihe-na -92.08, 151.91 APE8-dihe-in -57.84, 145.99 APE8-rot-out 175.35 APE67-dihe-in -65.98, -29.37 -55.72, -38.5 APE12-dist-in 13.1801 APE11-dist-in 12.6112 APE10-dist-in 7.008 APE9-dist-in 3.4323 K965R TPO893 TPO893 XRAY 3.08 0.187 0.211 E 344.0 325.0 0 29 29 0 [[727, 1020]] 1.0 8bun Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8P81A Q9NYV4 716 1035 1490.0 RMF:1101 Type1 Active DFGin 7.0954 14.4463 BLAminus -134.83, -178.64 59.2, 72.19 -89.53, 34.88 291.56, 80.44 -67.97, -22.73 in-in in 8.3586 Saltbr-in 3.0568 HRD-in -81.5, -42.97 59.01, 18.94 in-in-in SNCiii in-in ActLoopNT-in 2.9629 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -119.63, 165.61 APE9-dihe-na 67.08, 139.25 APE8-dihe-in -61.99, 152.33 APE8-rot-in 316.49 APE67-dihe-in -68.12, -20.85 -57.98, -41.98 APE12-dist-in 12.6789 APE11-dist-in 10.561 APE10-dist-in 6.5202 APE9-dist-in 3.2122 None TPO893 TPO893 XRAY 2.68 0.212 0.255 A 351.0 320.0 0 29 29 0 [[727, 1020]] 1.0 8p81 Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 8BU5E Q9NYV4 713 1043 1490.0 RMF:1101 Type1 Inactive DFGin 6.9424 15.1221 None -123.64, -63.66 -81.97, -51.09 56.28, 22.54 292.49, 98.9 -91.33, -28.22 in-out in 8.3713 Saltbr-out 3.6222 HRD-in -72.77, -54.57 74.45, -4.91 out-in-out SNCoio in-out ActLoopNT-in 2.7589 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -134.16, -27.33 APE9-dihe-na -98.05, 157.33 APE8-dihe-in -51.55, 136.25 APE8-rot-in 308.17 APE67-dihe-in -63.16, -26.85 -49.17, -41.17 APE12-dist-out 14.1246 APE11-dist-in 12.1682 APE10-dist-in 7.2856 APE9-dist-in 3.7263 K965R TPO893 TPO893 XRAY 3.134 0.2 0.22 E 344.0 331.0 0 29 29 0 [[727, 1020]] 1.0 8bu5 Homo sapiens CMGC_CDK12_HUMAN CMGC 5.4e-84 287.9 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK12 CDK12_HUMAN 9FMRB Q9NYV4 714 1047 1490.0 RMF:61101 Type1 Inactive DFGin 7.1242 15.0312 None -111.49, -74.26 -77.99, -72.15 68.85, 12.84 296.16, 89.8 -66.22, -36.51 in-out in 8.3316 Saltbr-out 4.4499 HRD-in -70.8, -35.56 62.81, 1.22 out-in-in SNCoii in-in ActLoopNT-in 3.0722 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.03, -25.75 APE9-dihe-na -103.56, 146.88 APE8-dihe-in -51.72, 138.27 APE8-rot-in 305.58 APE67-dihe-in -69.51, -21.36 -53.61, -35.19 APE12-dist-in 13.9874 APE11-dist-in 12.2701 APE10-dist-in 7.331 APE9-dist-in 3.8645 None TPO893 TPO893 XRAY 3.9 0.209 0.25 B 351.0 334.0 0 29 29 0 [[727, 1020]] 1.0 9fmr Homo sapiens CMGC_CDK12_HUMAN CMGC 2.9e-84 288.8 1.0 301.0 301.0 876 877 878 880 882 756 774 778 856 858 857 859.0 918 905 900 899 898 897 896 895 894 814 Cyclin-dependent kinase 12
CMGC CDK16 CDK16_HUMAN 3MTLA Q00536 163 473 496.0 FEF:60668 Type1 Inactive DFGout 17.3993 7.4716 None -75.13, 154.32 -88.9, 77.74 -154.62, 116.54 227.56, 88.74 78.03, 21.89 in-in in 8.3848 Saltbr-in 2.6411 HRD-out -101.69, 108.56 -74.19, -25.04 in-out-out SNCioo out-out ActLoopNT-out 5.1638 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 102.89 APE8-rot-out 156.53 APE67-dihe-in -61.54, -35.29 -78.56, -14.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S319D None None XRAY 2.4 0.198 0.263 A 324.0 293.0 18 28 16 12 [[165, 446]] 1.0 3mtl Homo sapiens CMGC_CDK16_HUMAN CMGC 1.3e-83 286.9 1.0 301.0 301.0 303 304 305 307 309 194 211 215 283 285 284 286.0 344 331 326 325 324 323 322 321 320 241 Cyclin-dependent kinase 16
CMGC CDK2 CDK2_HUMAN 9ESWA P24941 1 294 298.0 IJF:60301,IJF:60302,IJF:60303,IJF:60304 Allosteric,Type1,Allosteric,Allosteric Active DFGin 6.5148 15.2974 BLAminus -143.94, 174.07 58.52, 82.55 -94.4, 25.35 278.47, 68.95 -74.76, -22.16 in-in in 8.6366 Saltbr-in 3.1971 HRD-in -81.26, -58.57 77.56, 16.21 in-in-in SNCiii in-in ActLoopNT-in 2.9956 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -61.44, 160.94 APE9-dihe-na 81.67, 126.4 APE8-dihe-in -51.25, 136.17 APE8-rot-in 300.7 APE67-dihe-in -59.48, -16.12 -52.59, -48.63 APE12-dist-in 12.9968 APE11-dist-in 11.8966 APE10-dist-in 7.0228 APE9-dist-in 3.2038 None TPO160 TPO160 XRAY 2.38 0.233 0.239 A 302.0 294.0 0 28 28 0 [[4, 286]] 1.0 9esw Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9ESWC P24941 1 296 298.0 IJF:60301,IJF:60302,IJF:60303,IJF:60304 Allosteric,Type1,Allosteric,Allosteric Active DFGin 6.5764 15.209 BLAminus -137.9, -176.23 48.55, 71.41 -85.05, 25.18 283.44, 66.65 -62.35, -32.95 in-in in 8.4167 Saltbr-in 2.7633 HRD-in -83.58, -58.72 75.84, 9.9 in-in-in SNCiii in-in ActLoopNT-in 2.887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.32, 151.2 APE9-dihe-na 72.23, 131.64 APE8-dihe-in -58.77, 140.82 APE8-rot-in 312.4 APE67-dihe-in -51.92, -26.23 -42.04, -57.02 APE12-dist-in 12.7761 APE11-dist-in 10.1953 APE10-dist-in 6.9433 APE9-dist-in 3.2364 None TPO160 TPO160 XRAY 2.38 0.233 0.239 C 302.0 269.0 27 28 28 0 [[4, 286]] 1.0 9esw Homo sapiens CMGC_CDK2_HUMAN CMGC 6.7e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 9OB4A P24941 1 298 298.0 A1CAF:301 Type1 Active DFGin 7.0696 15.4326 BLAminus -140.78, 171.16 58.81, 81.21 -94.48, 18.25 279.35, 70.51 -60.63, -24.89 in-in in 8.7019 Saltbr-in 2.5781 HRD-in -77.49, -52.8 70.85, 9.99 in-in-in SNCiii in-in ActLoopNT-in 2.8582 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -103.4, 171.78 APE9-dihe-na 71.79, 138.58 APE8-dihe-in -59.97, 144.28 APE8-rot-in 298.9 APE67-dihe-in -65.05, -23.77 -53.99, -47.04 APE12-dist-in 13.1487 APE11-dist-in 12.2324 APE10-dist-in 7.357 APE9-dist-in 3.2609 None TPO160 TPO160 XRAY 1.95 0.211 0.251 A 301.0 298.0 0 28 28 0 [[4, 286]] 1.0 9ob4 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4BCQA P24941 1 295 298.0 TJF:61296 Type1 Active DFGin 6.5912 15.9794 BLAminus -145.97, 170.46 62.82, 84.99 -99.38, 29.59 282.23, 71.6 -71.19, -18.61 in-in in 9.4042 Saltbr-in 3.4531 HRD-in -85.05, -58.94 78.36, 12.61 in-in-in SNCiii in-in ActLoopNT-in 3.1475 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -116.8, 176.97 APE9-dihe-na 69.33, 133.29 APE8-dihe-in -55.38, 139.69 APE8-rot-in 304.09 APE67-dihe-in -55.84, -22.0 -49.63, -50.65 APE12-dist-in 13.6254 APE11-dist-in 12.5429 APE10-dist-in 7.4985 APE9-dist-in 3.5108 None TPO160 TPO160 XRAY 2.4 0.217 0.252 A 301.0 290.0 5 28 28 0 [[4, 286]] 1.0 4bcq Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4BCQC P24941 1 294 298.0 TJF:61295 Type1 Active DFGin 6.5396 16.003 BLAminus -147.36, 170.23 59.21, 86.27 -98.9, 28.16 278.44, 72.82 -71.37, -12.42 in-in in 9.5981 Saltbr-in 3.2615 HRD-in -88.13, -59.99 74.18, 19.51 in-in-in SNCiii in-in ActLoopNT-in 2.9087 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -136.48, 157.26 APE9-dihe-na 69.58, 129.95 APE8-dihe-in -57.66, 135.49 APE8-rot-in 301.27 APE67-dihe-in -62.84, -20.05 -48.44, -46.81 APE12-dist-in 13.5398 APE11-dist-in 10.6816 APE10-dist-in 7.6895 APE9-dist-in 3.6597 None TPO160 TPO160 XRAY 2.4 0.217 0.252 C 301.0 292.0 2 28 28 0 [[4, 286]] 1.0 4bcq Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 7S9XA P24941 3 298 298.0 8KF:301 Type3 Inactive DFGin 9.1518 14.9038 BLBminus -140.51, 174.83 55.24, 52.61 -60.52, 155.06 283.44, 65.83 -96.54, 51.03 out-out out 17.0211 Saltbr-out 17.4046 HRD-in -80.98, -57.39 84.63, -18.55 out-out-out SNCooo out-out ActLoopNT-out 9.2992 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 131.76 APE9-dihe-na -82.0, 133.39 APE8-dihe-in -82.83, 123.04 APE8-rot-in 299.71 APE67-dihe-in -59.76, -23.84 -102.49, -0.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.1199 APE9-dist-out 11.0222 None None None XRAY 1.69 0.231 0.262 A 298.0 269.0 27 28 16 12 [[4, 286]] 1.0 7s9x Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2W1HA P24941 1 298 298.0 L0F:1299 Type1 Inactive DFGin 10.3073 17.775 BLBtrans -130.06, 151.5 79.56, 18.75 -69.93, 141.61 226.73, 121.67 69.65, -12.05 out-out out 14.489 Saltbr-out 16.0385 HRD-in -88.39, -56.31 79.17, -16.22 out-out-out SNCooo out-out ActLoopNT-out 5.4567 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 121.46 APE8-dihe-in -76.22, 142.93 APE8-rot-out 186.46 APE67-dihe-in -49.35, -36.85 -110.85, -4.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.8052 None None None XRAY 2.15 0.263 0.308 A 298.0 283.0 15 28 17 11 [[4, 286]] 1.0 2w1h Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2R3IA P24941 1 298 298.0 SCF:60501 Type1 Inactive DFGin 10.9293 18.2404 BLBtrans -100.61, 149.54 71.45, 21.63 -58.2, 134.86 231.09, 103.4 83.18, -10.48 out-out out 15.0575 Saltbr-out 16.3446 HRD-in -91.01, -59.76 82.13, -15.3 out-out-out SNCooo out-out ActLoopNT-out 5.7069 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.45, 127.61 APE9-dihe-na -74.97, 122.45 APE8-dihe-in -60.32, 144.67 APE8-rot-out 191.76 APE67-dihe-in -59.78, -26.25 -99.25, -5.87 APE12-dist-out 20.1693 APE11-dist-out 17.5378 APE10-dist-out 18.8885 APE9-dist-out 9.9912 None None CSD177 XRAY 1.28 0.178 0.202 A 299.0 291.0 7 28 28 0 [[4, 286]] 1.0 2r3i Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 5IEXA P24941 1 298 298.0 6AF:1001 Type1 Inactive None 11.1059 18.3439 None -105.6, 149.53 71.37, 22.65 -61.85, 135.15 236.62, 103.3 74.49, -10.58 out-out out 15.1763 Saltbr-out 15.2259 HRD-in -80.72, -65.3 84.99, -26.41 out-out-out SNCooo out-out ActLoopNT-out 5.8019 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 111.81 APE8-dihe-in -112.57, 117.73 APE8-rot-in 277.98 APE67-dihe-in -67.92, -29.52 -99.02, -2.25 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2755 None None None XRAY 2.03 0.206 0.254 A 298.0 285.0 13 28 20 8 [[4, 286]] 1.0 5iex Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK6 CDK6_HUMAN 9PE7A Q00534 10 301 326.0 A1CIF:900 Type1 Inactive DFGin 6.8718 13.1269 BLBplus -137.4, 169.29 57.4, 61.63 -142.77, 164.35 61.09, 86.59 91.92, -16.71 out-out out 12.416 Saltbr-out 9.9299 HRD-in -63.73, -52.58 73.19, -16.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 162.46 APE9-dihe-na -100.9, 174.34 APE8-dihe-in -134.69, 96.5 APE8-rot-in 306.93 APE67-dihe-in -54.43, -27.6 -93.0, -5.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 22.3734 APE9-dist-out 12.123 E21V,K26T,T106R,Q149E None None XRAY 2.05 0.216 0.267 A 307.0 262.0 30 27 15 12 [[13, 300]] 1.0 9pe7 Homo sapiens CMGC_CDK6_HUMAN CMGC 3.7e-84 289.5 1.0 301.0 301.0 162 163 164 166 168 43 61 65 142 144 143 145.0 201 189 184 183 182 181 180 179 178 99 Cyclin-dependent kinase 6
CMGC CDK7 CDK7_HUMAN 8P71J P50613 10 310 346.0 X4F:60401 Type1 Active DFGin 6.8323 15.3042 BLAminus -139.46, 179.9 57.59, 64.02 -82.45, 17.71 282.17, 74.47 -64.72, -19.22 in-in in 8.1027 Saltbr-in 2.6939 HRD-in -67.33, -49.46 65.63, 5.51 in-in-in SNCiii in-in ActLoopNT-in 2.6395 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.68, 168.49 APE9-dihe-na 67.33, 140.05 APE8-dihe-in -60.3, 143.93 APE8-rot-in 294.53 APE67-dihe-in -61.0, -25.19 -55.87, -41.76 APE12-dist-in 13.411 APE11-dist-in 11.1922 APE10-dist-in 6.8033 APE9-dist-in 3.2758 None None None EM 2.0 999.0 999.0 J 349.0 286.0 15 28 28 0 [[12, 295]] 1.0 8p71 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.7 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK8 CDK8_HUMAN 9H8SA P49336 1 362 464.0 A1ITF:60509 Type1 Inactive DFGin 7.3437 13.9243 BLAminus -119.28, 163.44 74.84, 82.25 -92.61, 11.91 298.93, 132.0 -87.41, 10.8 in-in in 8.6117 Saltbr-in 2.6241 HRD-in -75.25, -51.5 79.06, -6.52 in-out-out SNCioo out-out ActLoopNT-out 8.6589 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 160.05 APE8-rot-out 75.96 APE67-dihe-in -54.19, -23.95 -111.96, 19.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.157 0.197 0.248 A 414.0 335.0 27 31 14 17 [[22, 335]] 1.0 9h8s Homo sapiens CMGC_CDK8_HUMAN CMGC 6.3e-82 281.3 5.0 301.0 297.0 172 173 174 176 178 52 66 70 148 150 149 151.0 216 203 198 197 196 195 194 193 192 98 Cyclin-dependent kinase 8
CMGC CSNK2A1 CSK21_HUMAN 8AEMA P68400 3 329 391.0 LVF:407,ATP:408 Allosteric,ATPlike Active DFGin 7.3989 16.1874 BLAminus -114.2, -178.47 56.21, 75.05 -90.39, 15.9 296.69, 81.8 -66.43, -20.83 in-in in 9.1318 Saltbr-in 2.816 HRD-in -72.91, -51.16 68.69, 11.11 in-in-in SNCiii in-in ActLoopNT-in 2.9049 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.83, 169.06 APE9-dihe-na 58.87, 157.76 APE8-dihe-in -77.1, 150.54 APE8-rot-in 294.73 APE67-dihe-in -68.78, -13.55 -40.19, -53.95 APE12-dist-in 12.7442 APE11-dist-in 10.4167 APE10-dist-in 6.256 APE9-dist-in 3.2152 R21S,K74A,K75A,K76A None None XRAY 1.6 0.19 0.212 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 8aem Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 9EPWB P68400 3 333 391.0 A1H6F:406 Type1 Active DFGin 7.3863 16.279 BLAminus -118.5, 178.76 54.91, 76.82 -86.63, 13.68 291.49, 81.55 -67.5, -20.83 out-in out 10.0457 Saltbr-in 3.2916 HRD-in -71.7, -52.07 70.7, 14.03 in-in-in SNCiii in-in ActLoopNT-in 2.8817 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.62, 167.98 APE9-dihe-na 70.49, 159.89 APE8-dihe-in -76.41, 141.74 APE8-rot-in 289.66 APE67-dihe-in -68.82, -20.3 -42.56, -42.98 APE12-dist-in 12.7948 APE11-dist-in 10.9212 APE10-dist-in 6.2791 APE9-dist-in 3.3821 None None None XRAY 2.3 0.261 0.308 B 338.0 331.0 0 27 27 0 [[39, 324]] 1.0 9epw Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.4e-69 240.6 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 2ZJWA P68400 1 332 391.0 REF:336 Type1 Inactive DFGin 7.3157 16.5266 BLAminus -109.16, -168.7 44.38, 76.01 -90.89, 24.26 297.46, 77.89 -76.15, -7.13 in-in in 9.4174 Saltbr-in 2.7312 HRD-in -72.0, -50.11 70.44, 13.49 in-in-out SNCiio in-out ActLoopNT-in 2.9068 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -14.58, 161.89 APE9-dihe-na 62.59, 163.98 APE8-dihe-in -84.5, 146.1 APE8-rot-out 153.88 APE67-dihe-in -63.0, -17.21 -40.84, -52.94 APE12-dist-in 12.6075 APE11-dist-in 8.9479 APE10-dist-in 5.933 APE9-dist-in 2.9919 None None None XRAY 2.4 0.222 0.274 A 340.0 332.0 0 27 27 0 [[39, 324]] 1.0 2zjw Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.4e-69 240.5 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7I8AA P68400 3 329 391.0 A1B0F:401 Type1 Active DFGin 7.4573 16.0714 BLAminus -110.77, 179.22 49.98, 83.2 -97.8, 27.66 295.37, 80.49 -74.55, -21.62 in-in in 8.9645 Saltbr-in 2.7479 HRD-in -69.35, -49.91 66.48, 13.83 in-in-in SNCiii in-in ActLoopNT-in 2.9297 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.27, 172.69 APE9-dihe-na 60.01, 160.49 APE8-dihe-in -88.34, 150.2 APE8-rot-in 298.89 APE67-dihe-in -68.6, -15.9 -36.65, -52.88 APE12-dist-in 12.6195 APE11-dist-in 10.1738 APE10-dist-in 6.1014 APE9-dist-in 3.048 R21S,K74A,K75A,K76A None None XRAY 1.84 0.196 0.234 A 328.0 323.0 4 27 27 0 [[39, 324]] 1.0 7i8a Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC DYRK1A DYR1A_HUMAN 6A1FA Q13627 134 483 763.0 9OF:807 Type1 Active DFGin 7.2047 15.0923 BLAminus -125.52, 173.04 69.56, 79.06 -100.37, 18.23 289.23, 81.85 -66.74, -28.25 in-in in 8.7124 Saltbr-in 2.8433 HRD-in -63.72, -44.37 75.39, -2.34 in-in-in SNCiii in-in ActLoopNT-in 2.8263 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.51, 164.33 APE9-dihe-na 78.19, 142.16 APE8-dihe-in -71.23, 146.24 APE8-rot-in 287.31 APE67-dihe-in -64.89, -24.24 -54.81, -45.1 APE12-dist-in 13.0008 APE11-dist-in 10.9373 APE10-dist-in 7.3973 APE9-dist-in 3.1888 None PTR321 PTR321 XRAY 1.5 0.178 0.195 A 360.0 346.0 4 25 25 0 [[159, 479]] 1.0 6a1f Homo sapiens CMGC_DYRK1A_HUMAN CMGC 8.3e-91 310.2 1.0 301.0 301.0 306 307 308 310 312 188 203 207 284 286 285 287.0 343 331 326 325 324 323 322 321 320 239 Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC DYRK2 DYRK2_HUMAN 7DH9A Q92630 215 538 601.0 H7F:601 Type1 Inactive DFGin 6.9547 15.3926 BLAminus -118.25, -176.44 52.33, 72.66 -86.4, 22.32 285.5, 71.17 -68.46, -16.6 in-in in 9.0913 Saltbr-in 2.8181 HRD-in -67.52, -48.86 77.78, -1.22 in-in-out SNCiio in-out ActLoopNT-in 2.8265 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.21, 165.64 APE9-dihe-na 77.26, 152.01 APE8-dihe-in -71.35, 136.19 APE8-rot-out 186.16 APE67-dihe-in -56.24, -27.47 -53.15, -48.91 APE12-dist-in 13.0845 APE11-dist-in 11.9349 APE10-dist-in 7.5884 APE9-dist-in 3.3083 None PTR382,SEP458 PTR382,SEP458 XRAY 2.194 0.19 0.218 A 324.0 324.0 0 25 25 0 [[222, 535]] 1.0 7dh9 Homo sapiens CMGC_DYRK2_HUMAN CMGC 5.4e-99 337.1 1.0 301.0 301.0 367 368 369 371 373 251 266 270 345 347 346 348.0 404 392 387 386 385 384 383 382 381 302 Dual specificity tyrosine-phosphorylation-regulated kinase 2
CMGC GSK3B GSK3B_HUMAN 9PE9A P49841 36 382 420.0 A1CIF:900 Type1 Inactive DFGin 7.0716 14.2287 BLAminus -128.7, -179.96 59.31, 84.1 -97.11, 26.91 283.64, 74.63 -73.69, -18.15 in-in in 8.351 Saltbr-in 2.7255 HRD-in -68.62, -45.57 65.7, 16.55 in-in-out SNCiio in-out ActLoopNT-in 2.9248 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -143.94, 165.33 APE9-dihe-na 76.34, 152.28 APE8-dihe-in -69.82, 130.62 APE8-rot-out 176.66 APE67-dihe-in -58.68, -26.71 -39.69, -56.4 APE12-dist-in 13.2799 APE11-dist-in 11.7578 APE10-dist-in 7.0929 APE9-dist-in 3.1547 None PTR216 PTR216 XRAY 2.11 0.221 0.247 A 359.0 332.0 13 27 27 0 [[56, 340]] 1.0 9pe9 Homo sapiens CMGC_GSK3B_HUMAN CMGC 2e-70 243.6 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 9PE9B P49841 36 382 420.0 A1CIF:900 Type1 Inactive DFGin 7.0575 14.2183 BLAminus -128.76, -179.81 59.6, 84.42 -97.78, 27.09 283.79, 74.38 -73.25, -17.71 in-in in 8.3532 Saltbr-in 2.7132 HRD-in -68.49, -44.82 64.55, 18.32 in-in-out SNCiio in-out ActLoopNT-in 2.9402 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -144.27, 163.74 APE9-dihe-na 77.64, 152.05 APE8-dihe-in -69.14, 130.82 APE8-rot-out 177.12 APE67-dihe-in -58.92, -26.81 -39.96, -55.88 APE12-dist-in 13.3604 APE11-dist-in 11.8241 APE10-dist-in 7.1609 APE9-dist-in 3.1723 None PTR216 PTR216 XRAY 2.11 0.221 0.247 B 359.0 332.0 13 27 27 0 [[56, 340]] 1.0 9pe9 Homo sapiens CMGC_GSK3B_HUMAN CMGC 2e-70 243.6 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 4PTEA P49841 36 382 420.0 2WF:501 Type1 Active DFGin 6.9317 14.0172 BLAminus -141.21, 178.04 57.99, 89.39 -100.23, 24.26 286.38, 75.9 -68.08, -19.02 in-in in 8.7161 Saltbr-in 2.6354 HRD-in -73.56, -44.45 69.11, 4.74 in-in-in SNCiii in-in ActLoopNT-in 2.7924 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -83.74, 175.98 APE9-dihe-na 75.98, 148.82 APE8-dihe-in -103.79, 152.51 APE8-rot-in 295.33 APE67-dihe-inflip 95.08, -28.26 -38.95, 126.56 APE12-dist-in 12.9786 APE11-dist-in 10.8902 APE10-dist-in 5.8826 APE9-dist-in 3.0881 None None None XRAY 2.033 0.17 0.195 A 441.0 341.0 6 27 27 0 [[56, 340]] 1.0 4pte Homo sapiens CMGC_GSK3B_HUMAN CMGC 3.7e-70 242.6 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 4PTEB P49841 36 385 420.0 2WF:501 Type1 Active DFGin 6.9181 13.9369 BLAminus -137.07, 179.43 58.52, 88.98 -101.38, 27.88 284.28, 76.88 -69.85, -20.65 in-in in 8.4836 Saltbr-in 2.6854 HRD-in -70.9, -46.61 73.05, 2.3 in-in-in SNCiii in-in ActLoopNT-in 2.8872 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -87.76, 178.59 APE9-dihe-na 72.73, 147.77 APE8-dihe-in -103.48, 150.66 APE8-rot-in 296.89 APE67-dihe-inflip 94.67, -27.57 -36.66, 125.81 APE12-dist-in 12.9354 APE11-dist-in 10.8805 APE10-dist-in 5.8765 APE9-dist-in 3.1539 None None None XRAY 2.033 0.17 0.195 B 441.0 347.0 3 27 27 0 [[56, 340]] 1.0 4pte Homo sapiens CMGC_GSK3B_HUMAN CMGC 3.7e-70 242.6 1.0 301.0 301.0 199 200 201 203 205 85 97 101 178 180 179 181.0 239 226 221 220 219 218 217 216 215 133 Glycogen synthase kinase-3 beta
CMGC MAPK1 MK01_HUMAN 5BVDA P28482 9 358 360.0 4VF:60401 Type1 None DFGin 7.0124 14.8201 BLAminus -120.88, -174.96 58.49, 83.25 -99.87, 23.43 283.53, 71.8 -56.85, -34.73 in-in in 9.2645 Saltbr-in 2.6271 HRD-in -80.64, -49.81 78.16, -6.37 in-in-none SNCiin in-none ActLoopNT-in 2.7197 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 122.19 APE8-rot-in 306.38 APE67-dihe-in -62.44, -24.22 -51.26, -49.02 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.172 0.207 A 361.0 330.0 20 31 15 16 [[25, 313]] 1.0 5bvd Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.2e-86 293.7 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8AO6A P28482 11 356 360.0 N9F:406 Type1 Inactive DFGin 6.7709 16.337 BLAminus -129.81, 177.88 71.62, 78.81 -103.22, 23.44 283.23, 73.97 -64.0, -29.38 out-in out 10.3714 Saltbr-in 2.597 HRD-in -72.45, -50.74 72.14, 4.83 in-in-out SNCiio in-out ActLoopNT-in 2.7853 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -96.92, -36.24 APE9-dihe-na -66.98, 156.39 APE8-dihe-in -51.35, 125.27 APE8-rot-in 311.93 APE67-dihe-in -64.42, -17.18 -56.32, -47.54 APE12-dist-out 14.4141 APE11-dist-in 11.1069 APE10-dist-in 7.1029 APE9-dist-in 4.2638 None None CME127,CME161 XRAY 1.811 0.175 0.222 A 368.0 338.0 0 31 31 0 [[25, 313]] 1.0 8ao6 Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.9e-86 293.6 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_HUMAN 8AO9A P28482 11 356 360.0 N4F:406 Type1 Inactive DFGin 6.837 16.4502 BLAminus -129.5, 178.83 61.88, 81.37 -96.97, 21.21 286.14, 78.83 -59.7, -30.7 out-out out 10.3006 Saltbr-out 3.7652 HRD-in -72.95, -49.65 72.84, 3.98 out-in-out SNCoio in-out ActLoopNT-in 2.8539 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -91.06, -44.4 APE9-dihe-na -60.28, 156.59 APE8-dihe-in -55.09, 130.24 APE8-rot-in 307.62 APE67-dihe-in -64.58, -17.09 -62.44, -44.52 APE12-dist-out 14.2701 APE11-dist-in 10.9807 APE10-dist-in 6.7892 APE9-dist-in 4.2298 None None CME161 XRAY 1.624 0.184 0.232 A 368.0 338.0 2 31 31 0 [[25, 313]] 1.0 8ao9 Homo sapiens CMGC_MAPK1_HUMAN CMGC 9.9e-86 293.6 1.0 301.0 301.0 166 167 168 170 172 54 71 75 146 148 147 149.0 210 197 192 191 190 189 188 187 186 106 Mitogen-activated protein kinase 1
CMGC MAPK10 MK10_HUMAN 3CGFA P53779 45 400 464.0 JNF:523 Type1 Inactive DFGin 3.7194 14.0388 ABAminus -89.59, -53.32 -106.99, -179.49 -117.03, 20.53 309.75, 79.33 76.52, -162.79 in-out in 9.6016 Saltbr-out 3.6113 HRD-in -43.19, -70.09 72.17, 4.64 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -63.93, 178.32 APE9-dihe-na -126.54, 145.54 APE8-dihe-in -86.07, 133.09 APE8-rot-in 307.62 APE67-dihe-in -51.07, -34.7 -123.34, -6.64 APE12-dist-out 21.3349 APE11-dist-out 17.8933 APE10-dist-out 16.6152 APE9-dist-out 11.4736 None None None XRAY 3.0 0.225 0.317 A 365.0 346.0 5 27 22 5 [[64, 359]] 1.0 3cgf Homo sapiens CMGC_MAPK10_HUMAN CMGC 1.4e-85 293.1 1.0 301.0 301.0 206 207 208 210 212 93 111 115 186 188 187 189.0 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK10 MK10_HUMAN 7YL1A P53779 45 400 464.0 J6F:501 Type1 Inactive DFGin 3.9949 14.0597 ABAminus -80.16, -27.18 -141.36, 174.64 -114.52, 17.98 302.24, 85.17 76.51, -161.32 in-in in 9.2297 Saltbr-in 2.7546 HRD-in -85.09, -59.15 76.16, -2.31 in-out-out SNCioo out-out ActLoopNT-out 6.4415 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -89.31, 134.84 APE9-dihe-na -84.54, 138.55 APE8-dihe-in -77.28, 127.44 APE8-rot-in 291.87 APE67-dihe-in -54.76, -19.99 -106.7, -13.11 APE12-dist-out 20.7213 APE11-dist-out 15.8773 APE10-dist-out 16.1956 APE9-dist-out 11.2727 None None None XRAY 2.48 0.208 0.294 A 464.0 352.0 2 27 25 2 [[64, 359]] 1.0 7yl1 Homo sapiens CMGC_MAPK10_HUMAN CMGC 3e-85 292.1 1.0 301.0 301.0 206 207 208 210 212 93 111 115 186 188 187 189.0 245 233 228 227 226 225 224 223 222 147 Mitogen-activated protein kinase 10
CMGC MAPK14 MK14_HUMAN 6ZQSA Q16539 4 353 360.0 3FF:400 Type1 Inactive DFGin 7.1312 15.0067 BLAminus -100.05, 172.92 58.72, 89.64 -100.69, 26.63 286.71, 76.86 -66.14, -26.38 out-out out 10.2824 Saltbr-out 3.9201 HRD-in -83.97, -53.39 74.81, 10.18 out-in-in SNCoii in-in ActLoopNT-in 2.8547 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.23, 173.02 APE9-dihe-na 73.87, 161.94 APE8-dihe-in -91.46, 139.33 APE8-rot-in 294.96 APE67-dihe-in -66.05, -18.45 -53.95, -45.87 APE12-dist-in 11.599 APE11-dist-in 11.174 APE10-dist-in 6.7713 APE9-dist-in 3.0458 None TPO180,PTR182 TPO180,PTR182 XRAY 1.95 0.178 0.223 A 362.0 350.0 0 25 25 0 [[24, 308]] 1.0 6zqs Homo sapiens CMGC_MAPK14_HUMAN CMGC 6e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 5XYYA Q16539 4 352 360.0 P0F:401 Type1.5_Back Inactive DFGin 8.1438 16.2502 BLBminus -111.25, 174.05 61.59, 81.71 -109.03, 145.8 286.82, 89.51 69.26, 21.62 in-in in 8.942 Saltbr-in 2.6487 HRD-in -68.14, -52.86 82.9, -10.64 in-out-out SNCioo out-out ActLoopNT-out 11.4762 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.86, 131.59 APE9-dihe-na -62.4, -17.36 APE8-dihe-out -62.41, -19.09 APE8-rot-out 53.75 APE67-dihe-in -64.55, -20.22 -114.48, -18.89 APE12-dist-out 21.1385 APE11-dist-out 22.895 APE10-dist-out 17.0927 APE9-dist-out 11.7589 None None None XRAY 1.7 0.18 0.201 A 380.0 343.0 6 25 25 0 [[24, 308]] 1.0 5xyy Homo sapiens CMGC_MAPK14_HUMAN CMGC 7e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 2QD9A Q16539 5 352 360.0 LGF:361 Type1 Inactive DFGin 5.1343 13.7971 BLBplus -108.86, 148.96 74.79, 24.8 -73.05, 150.79 49.54, 82.76 82.07, 6.15 in-in in 9.155 Saltbr-in 2.5566 HRD-in -76.06, -55.95 78.8, -20.76 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -59.56, -22.52 999.0, -59.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.252 0.282 A 366.0 330.0 18 25 12 13 [[24, 308]] 1.0 2qd9 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3QUDA Q16539 4 354 360.0 N3F:361 Type1 Inactive DFGin 10.8012 12.5528 None -93.66, 153.34 -68.51, -47.3 -136.82, 128.38 301.98, 103.1 -95.02, -166.54 in-in in 9.269 Saltbr-in 3.5549 HRD-in -63.42, -58.28 80.41, -12.58 in-out-out SNCioo out-out ActLoopNT-out 20.8014 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 112.75 APE9-dihe-na -76.37, 136.79 APE8-dihe-out -65.47, -38.0 APE8-rot-in 295.71 APE67-dihe-in -57.05, -26.46 -56.48, -28.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 10.7622 APE9-dist-out 12.6517 None None None XRAY 2.0 0.234 0.278 A 360.0 345.0 6 25 19 6 [[24, 308]] 1.0 3qud Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3QUEA Q16539 5 353 360.0 3FF:362 Type1 Inactive DFGin 10.6415 12.3386 None -82.41, 155.86 -75.27, -54.23 -130.98, 134.23 308.77, 88.25 -97.08, -170.31 in-in in 8.9604 Saltbr-in 2.6567 HRD-in -64.83, -54.13 86.66, -27.06 in-out-out SNCioo out-out ActLoopNT-out 21.2792 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 66.84 APE9-dihe-na -77.78, 135.56 APE8-dihe-out -48.89, -54.16 APE8-rot-in 280.74 APE67-dihe-in -53.38, -25.8 -51.95, -34.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.1952 APE9-dist-out 11.3927 None None None XRAY 2.7 0.23 0.311 A 360.0 343.0 6 25 19 6 [[24, 308]] 1.0 3que Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4R3CA Q16539 4 352 360.0 3GF:402,3GF:403 Type1,Allosteric Inactive DFGin 4.9243 13.1341 None -118.67, 171.2 49.4, 42.48 -86.86, 999.0 38.51, 75.43 999.0, 999.0 in-out in 9.5432 Saltbr-out 3.9084 HRD-in -66.01, -56.32 81.1, -14.57 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 103.85 APE9-dihe-na -65.1, 130.86 APE8-dihe-out -51.86, -39.46 APE8-rot-in 289.55 APE67-dihe-in -62.53, -25.36 -48.44, -37.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.2638 None None CME162 XRAY 2.06 0.178 0.217 A 383.0 336.0 13 25 12 13 [[24, 308]] 1.0 4r3c Homo sapiens CMGC_MAPK14_HUMAN CMGC 7.2e-85 290.9 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3L8SA Q16539 4 353 360.0 BFF:361 Type1 Inactive DFGout 15.4888 11.9771 None -119.54, 162.4 -99.13, -16.66 31.92, 999.0 247.73, 144.9 999.0, 999.0 in-in in 9.4966 Saltbr-in 2.8175 HRD-in -77.51, -50.13 90.87, -25.05 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 107.11 APE9-dihe-na -94.83, 118.78 APE8-dihe-out -62.16, -3.07 APE8-rot-out 173.18 APE67-dihe-in -59.13, -22.21 -95.45, -15.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.2005 C119S,C162S,A172C,F327L None None XRAY 2.35 0.242 0.307 A 360.0 334.0 16 25 12 13 [[24, 308]] 1.0 3l8s Homo sapiens CMGC_MAPK14_HUMAN CMGC 4.4e-84 288.3 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3UVRA Q16539 5 351 360.0 06F:361 Type2 Inactive DFGout 15.5607 8.5245 None -148.63, 178.6 -133.58, 101.18 -90.01, -1.78 195.55, 17.77 -54.07, 127.45 in-in in 8.2112 Saltbr-in 2.6266 HRD-in -62.71, -55.49 83.79, -17.62 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -56.89 APE8-dihe-out -51.15, -30.26 APE8-rot-in 300.71 APE67-dihe-in -70.54, -25.21 -93.95, -15.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.6213 None None None XRAY 2.1 0.204 0.245 A 360.0 331.0 16 25 13 12 [[24, 308]] 1.0 3uvr Homo sapiens CMGC_MAPK14_HUMAN CMGC 5.9e-85 291.1 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK8 MK08_HUMAN 8PTAA P45983 8 363 427.0 CIF:401 Type1 Inactive DFGin 3.923 14.4771 ABAminus -80.58, -61.37 -103.85, 165.38 -100.79, 23.99 295.77, 91.74 73.84, -149.47 in-in in 9.7897 Saltbr-in 3.1262 HRD-in -78.59, -61.53 62.23, 7.12 in-out-out SNCioo out-out ActLoopNT-out 6.4702 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -130.45, 138.38 APE9-dihe-na -101.99, 109.25 APE8-dihe-in -118.89, 112.23 APE8-rot-out 53.5 APE67-dihe-in -51.79, -30.07 -95.29, -17.54 APE12-dist-in 10.569 APE11-dist-out 7.0333 APE10-dist-out 10.1833 APE9-dist-out 8.5978 None None None XRAY 2.41 0.224 0.226 A 366.0 354.0 2 27 25 2 [[26, 321]] 1.0 8pta Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 8PTAB P45983 7 363 427.0 CIF:401 Type1 Inactive DFGin 3.5773 13.1788 ABAminus -81.24, -57.35 -101.3, 158.61 -105.36, 14.2 308.93, 93.28 64.59, -148.13 in-in in 9.3658 Saltbr-in 3.5356 HRD-in -77.41, -61.25 61.49, 9.23 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -112.33, 168.25 APE9-dihe-na -116.9, 36.67 APE8-dihe-in -104.63, 91.0 APE8-rot-out 52.55 APE67-dihe-in -56.88, -29.41 -95.02, -21.65 APE12-dist-in 11.7839 APE11-dist-in 9.1521 APE10-dist-out 11.2421 APE9-dist-out 10.2145 None None None XRAY 2.41 0.224 0.226 B 366.0 352.0 5 27 22 5 [[26, 321]] 1.0 8pta Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK8 MK08_HUMAN 8PTAC P45983 8 361 427.0 CIF:401 Type1 Inactive DFGin 3.8263 14.0885 ABAminus -83.97, -56.35 -97.04, 154.46 -105.76, 13.83 294.99, 32.04 63.79, -147.27 in-out in 9.7228 Saltbr-out 4.5276 HRD-in -77.01, -60.9 63.25, 7.56 out-out-out SNCooo out-out ActLoopNT-out 4.6109 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -137.59 APE9-dihe-na -94.11, 17.64 APE8-dihe-in -81.48, 63.35 APE8-rot-out 71.39 APE67-dihe-in -58.68, -26.77 -108.19, -24.77 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.4666 APE9-dist-out 10.7804 None None None XRAY 2.41 0.224 0.226 C 366.0 351.0 3 27 24 3 [[26, 321]] 1.0 8pta Homo sapiens CMGC_MAPK8_HUMAN CMGC 8.1e-85 290.6 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 8
CMGC MAPK9 MK09_HUMAN 3E7OA P45984 9 361 424.0 35F:1 Type1 Inactive DFGin 4.2658 14.5259 ABAminus -84.35, -29.35 -149.55, 177.24 -106.27, 9.79 301.22, 95.14 60.95, -143.01 in-in in 9.4394 Saltbr-in 2.6864 HRD-in -64.97, -51.12 67.58, -6.1 in-out-out SNCioo out-out ActLoopNT-out 5.5191 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -84.71, -45.82 APE9-dihe-na -76.84, -178.43 APE8-dihe-in -88.6, 137.99 APE8-rot-in 266.04 APE67-dihe-out -72.72, -13.34 -138.1, 64.96 APE12-dist-out 20.2903 APE11-dist-out 15.6856 APE10-dist-out 19.3278 APE9-dist-out 14.6648 C177S,C222S,K250A,K251A,K265A,K270A None None XRAY 2.14 0.219 0.25 A 360.0 342.0 2 27 27 0 [[26, 321]] 1.0 3e7o Homo sapiens CMGC_MAPK9_HUMAN CMGC 2.7e-84 288.8 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 9
CMGC MAPK9 MK09_HUMAN 3E7OB P45984 8 362 424.0 35F:2 Type1 Inactive DFGin 4.2756 14.3183 ABAminus -85.32, -37.61 -133.45, 175.33 -107.39, 15.94 299.45, 88.14 90.36, 999.0 in-in in 9.4665 Saltbr-in 2.8008 HRD-in -71.07, -57.75 72.11, -12.31 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -39.52 APE8-rot-out 181.64 APE67-dihe-in -65.99, -17.44 -49.19, -35.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C177S,C222S,K250A,K251A,K265A,K270A None None XRAY 2.14 0.219 0.25 B 360.0 326.0 19 27 11 16 [[26, 321]] 1.0 3e7o Homo sapiens CMGC_MAPK9_HUMAN CMGC 2.7e-84 288.8 1.0 301.0 301.0 168 169 170 172 174 55 73 77 148 150 149 151.0 207 195 190 189 188 187 186 185 184 109 Mitogen-activated protein kinase 9
OTHER CDC7 CDC7_HUMAN 6YA8A O00311 38 572 574.0 ADP:60601,BEF:60603 ATPlike,Allosteric None DFGin 6.1681 14.0868 BLAminus -118.93, 173.08 76.34, 83.66 -102.33, 21.87 291.62, 81.2 -67.07, -22.7 in-in in 8.7089 Saltbr-in 2.7382 HRD-in -65.76, -44.2 72.35, -4.4 in-in-none SNCiin in-none ActLoopNT-in 2.755 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na -83.06, -154.71 APE8-dihe-in -48.63, 132.1 APE8-rot-in 306.86 APE67-dihe-in -66.07, -7.37 -59.08, -35.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.8876 None None None XRAY 1.79 0.167 0.197 A 359.0 338.0 13 188 175 13 [[58, 569]] 1.0 6ya8 Homo sapiens OTHER_CDC7_HUMAN CMGC 2e-18 137.3 1.0 161.0 296.0 195 196 197 199 201 90 104 108 174 176 175 177.0 396 383 378 377 376 375 0 0 0 135 Cell division cycle 7-related protein kinase
OTHER GAK GAK_HUMAN 4C57A O14976 25 334 1311.0 FEF:1340 Type1 Inactive DFGin 5.7541 14.1406 ABAminus -112.53, -37.31 -102.07, 134.52 -132.21, 22.67 297.88, 98.14 -59.75, -31.11 in-out in 9.9935 Saltbr-out 4.0566 HRD-in -62.14, -51.36 70.7, -5.09 out-in-in SNCoii in-in ActLoopNT-in 2.8949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.34, 3.52 APE9-dihe-na -124.99, 156.99 APE8-dihe-in -84.98, 122.71 APE8-rot-in 297.75 APE67-dihe-in -71.57, -19.62 -46.23, -44.89 APE12-dist-in 11.7793 APE11-dist-in 8.5735 APE10-dist-in 4.3301 APE9-dist-in 4.0704 None None None XRAY 2.55 0.18 0.228 A 340.0 310.0 0 40 40 0 [[40, 313]] 1.0 4c57 Homo sapiens OTHER_GAK_HUMAN CAMK 5.3e-44 156.7 3.0 252.0 250.0 190 191 192 194 196 69 85 89 170 172 171 173.0 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 4C57B O14976 27 334 1311.0 FEF:1337 Type1 Inactive DFGin 5.7695 14.2334 ABAminus -105.07, -37.59 -101.51, 133.86 -130.57, 22.88 297.9, 97.48 -60.27, -26.81 out-out out 10.0646 Saltbr-out 4.0563 HRD-in -62.14, -52.49 71.3, -9.85 out-in-in SNCoii in-in ActLoopNT-in 2.8914 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -106.07, 5.67 APE9-dihe-na -124.2, 156.66 APE8-dihe-in -83.72, 121.96 APE8-rot-in 296.0 APE67-dihe-in -71.56, -19.42 -45.7, -45.17 APE12-dist-in 11.9284 APE11-dist-in 8.6579 APE10-dist-in 4.358 APE9-dist-in 4.0859 None None None XRAY 2.55 0.18 0.228 B 340.0 308.0 0 40 40 0 [[40, 313]] 1.0 4c57 Homo sapiens OTHER_GAK_HUMAN CAMK 5.3e-44 156.7 3.0 252.0 250.0 190 191 192 194 196 69 85 89 170 172 171 173.0 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER GAK GAK_HUMAN 4C59A O14976 27 333 1311.0 FEF:1334 Type1 Inactive DFGin 5.8147 13.6797 ABAminus -134.62, -10.32 -105.18, 88.43 -107.04, 23.92 300.54, 105.0 -81.95, -10.0 in-in in 9.0927 Saltbr-in 2.8554 HRD-in -82.36, -54.36 82.63, -15.13 in-in-none SNCiin in-none ActLoopNT-in 2.8383 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.205 0.262 A 340.0 266.0 41 40 13 27 [[40, 313]] 1.0 4c59 Homo sapiens OTHER_GAK_HUMAN CAMK 5.3e-44 156.7 3.0 252.0 250.0 190 191 192 194 196 69 85 89 170 172 171 173.0 245 230 225 224 223 222 221 220 219 124 Cyclin-G-associated kinase
OTHER HASPIN HASP_HUMAN 9FLTA Q8TF76 471 798 798.0 A1IDF:801 Type1 Active DFGin 5.1776 12.2183 BLAminus -141.02, 178.95 59.99, 70.73 -81.95, 27.03 316.78, 141.24 -69.29, -28.67 in-in in 8.7595 Saltbr-in 2.4634 HRD-naN -66.6, -53.16 75.71, 6.9 in-in-na SNCiia in-na ActLoopNT-in 2.9046 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -131.58, 41.34 APE9-dihe-na -102.69, 164.5 APE8-dihe-na -162.68, -171.46 APE8-rot-na 41.52 APE67-dihe-na -134.91, 146.64 100.36, -24.97 APE12-dist-na 9.6398 APE11-dist-na 13.5093 APE10-dist-na 17.2466 APE9-dist-na 13.2789 None None None XRAY 2.4 0.187 0.239 A 336.0 320.0 8 35 35 0 [[484, 797]] 1.0 9flt Homo sapiens OTHER_HASPIN_HUMAN HASP 1.1e-226 756.9 1.0 314.0 314.0 686 687 688 690 692 511 535 539 646 648 647 649.0 741 721 716 715 714 713 712 711 710 604 Serine/threonine-protein kinase haspin
OTHER TTK TTK_HUMAN 4JS8A P33981 515 793 857.0 1PF:801 Type1 Inactive DFGin 4.2459 15.0178 ABAminus -84.57, -49.34 -133.98, 167.4 -109.17, 14.51 305.07, 151.28 67.69, 15.63 in-out in 9.9926 Saltbr-out 6.6989 HRD-in -62.96, -52.34 70.46, -10.5 out-out-out SNCooo out-out ActLoopNT-out 12.0357 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnoo APE10-dihe-na 999.0, 112.01 APE9-dihe-na -104.69, -175.56 APE8-dihe-in -119.7, 153.55 APE8-rot-none 999.0 APE67-dihe-in -65.36, -29.34 -115.57, 0.38 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.1985 APE9-dist-out 12.1114 None TPO675,TPO686 TPO675,TPO686 XRAY 1.94 0.232 0.253 A 281.0 261.0 18 30 22 8 [[525, 791]] 1.0 4js8 Homo sapiens OTHER_TTK_HUMAN CAMK 5.6e-54 189.1 1.0 256.0 256.0 663 664 665 667 669 553 571 575 644 646 645 647.0 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER TTK TTK_HUMAN 7CHMA P33981 516 794 857.0 FZF:801 Type1 Inactive DFGin 4.4135 14.6083 None -111.88, -71.82 -63.89, 158.67 -119.5, 9.1 283.45, 179.72 82.92, -15.75 in-in in 9.5598 Saltbr-in 3.396 HRD-in -57.59, -51.23 60.31, 6.24 in-out-out SNCioo out-out ActLoopNT-out 12.2637 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, -62.47 APE9-dihe-na 66.11, 172.68 APE8-dihe-out -121.28, -175.85 APE8-rot-none 999.0 APE67-dihe-in -54.56, -33.62 -132.81, 0.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.8631 APE9-dist-out 12.904 None TPO675,TPO686 TPO675,TPO686 XRAY 2.65 0.212 0.253 A 281.0 260.0 19 30 22 8 [[525, 791]] 1.0 7chm Homo sapiens OTHER_TTK_HUMAN CAMK 5.6e-54 189.1 1.0 256.0 256.0 663 664 665 667 669 553 571 575 644 646 645 647.0 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
OTHER ULK1 ULK1_HUMAN 4WNOA O75385 8 280 1050.0 3RF:401 Type1 Active DFGin 6.8894 14.9489 BLAminus -117.94, 169.26 64.81, 74.6 -94.14, 20.86 282.18, 71.59 -63.55, -24.11 in-in in 7.6619 Saltbr-in 2.7703 HRD-in -82.57, -51.36 80.06, -2.07 in-in-in SNCiii in-in ActLoopNT-in 2.9659 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.03, 162.62 APE9-dihe-na 120.91, -162.5 APE8-dihe-in -119.54, 124.2 APE8-rot-in 305.96 APE67-dihe-in -67.71, -19.19 -53.63, -37.75 APE12-dist-in 8.2136 APE11-dist-in 11.2124 APE10-dist-in 5.6751 APE9-dist-in 3.309 E37A,K38A TPO180 TPO180 XRAY 1.56 0.18 0.208 A 287.0 273.0 0 27 27 0 [[14, 278]] 1.0 4wno Homo sapiens OTHER_ULK1_HUMAN ULK 2.1e-132 446.2 1.0 256.0 256.0 164 165 166 168 170 46 63 67 135 137 136 138.0 203 191 186 185 184 183 182 181 180 93 Serine/threonine-protein kinase ULK1
STE MAP2K1 MP2K1_HUMAN 7UMBC Q02750 41 381 393.0 ANP:401,U9F:402 ATPlike,Type3 Inactive DFGin 6.169 13.7668 BLBplus -162.24, 171.11 70.21, 49.7 -113.95, 160.88 44.65, 94.08 -79.06, 81.13 out-out out 15.5589 Saltbr-out 15.2725 HRD-in -66.12, -48.09 76.83, -9.86 out-out-out SNCooo out-out ActLoopNT-out 9.5911 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -127.94, 139.36 APE9-dihe-na -138.86, -160.81 APE8-dihe-out -82.2, -18.64 APE8-rot-out 50.9 APE67-dihe-out -106.39, 139.13 -104.8, 110.61 APE12-dist-out 16.6992 APE11-dist-out 19.6656 APE10-dist-out 21.5701 APE9-dist-out 14.915 None None None XRAY 3.231 0.231 0.268 C 384.0 303.0 38 26 26 0 [[68, 361]] 1.0 7umb Homo sapiens STE_MAP2K1_HUMAN STE 2.3e-97 331.4 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K7 MP2K7_HUMAN 6YG3A O14733 103 400 419.0 6HF:60510 Type1 None DFGin 6.1952 14.5493 BLAminus -146.55, 178.23 54.3, 83.97 -103.73, 30.03 316.89, 91.95 -57.17, -29.89 in-na in 8.3452 Saltbr-na 3.3604 HRD-in -81.36, -52.29 76.4, 12.98 na-in-none SNCain in-none ActLoopNT-in 2.9822 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.05 0.191 0.235 A 307.0 265.0 33 27 8 19 [[120, 380]] 1.0 6yg3 Homo sapiens STE_MAP2K7_HUMAN STE 2.4e-80 275.5 2.0 257.0 256.0 260 261 262 264 266 149 166 170 240 242 241 243.0 304 287 282 281 280 279 278 277 276 197 Dual specificity mitogen-activated protein kinase kinase 7
STE MAP4K1 M4K1_HUMAN 8FH4A Q92918 4 293 833.0 XXF:60401 Type1 Inactive DFGin 6.8462 14.4745 BLAminus -131.99, 171.23 62.34, 86.7 -92.12, 20.1 289.3, 88.42 -59.7, -48.05 in-in in 9.2322 Saltbr-in 2.734 HRD-in -67.47, -51.18 67.4, 4.94 in-out-out SNCioo out-out ActLoopNT-out 6.1988 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -73.65, -44.57 APE9-dihe-na 76.29, -171.23 APE8-dihe-in -62.48, 141.12 APE8-rot-out 34.25 APE67-dihe-in -59.58, -27.68 -102.29, 0.49 APE12-dist-out 20.3044 APE11-dist-out 21.0787 APE10-dist-out 21.4211 APE9-dist-out 27.2591 T165E,S171E None None XRAY 1.827 0.189 0.215 A 331.0 290.0 0 28 28 0 [[17, 274]] 1.0 8fh4 Homo sapiens STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FH4B Q92918 6 302 833.0 XXF:60402 Type1 Inactive DFGin 6.5509 14.2937 BLAminus -141.43, 174.43 62.64, 85.33 -93.2, 13.55 285.99, 85.49 -57.34, -45.75 in-in in 8.9388 Saltbr-in 2.6969 HRD-in -67.85, -50.88 67.73, 2.48 in-out-out SNCioo out-out ActLoopNT-out 6.3091 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -67.39, -32.57 APE9-dihe-na 75.42, -167.37 APE8-dihe-in -61.44, 126.8 APE8-rot-out 59.49 APE67-dihe-in -56.24, -30.95 -97.05, -0.91 APE12-dist-out 19.4642 APE11-dist-out 20.5862 APE10-dist-out 21.6649 APE9-dist-out 28.0466 T165E,S171E None None XRAY 1.827 0.189 0.215 B 331.0 297.0 0 28 28 0 [[17, 274]] 1.0 8fh4 Homo sapiens STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FH4C Q92918 1 292 833.0 XXF:60401 Type1 Inactive DFGin 6.8242 14.1178 BLAminus -136.31, 172.65 64.01, 85.1 -95.02, 19.77 288.84, 83.7 -61.21, -46.39 in-in in 8.9671 Saltbr-in 2.7326 HRD-in -69.91, -50.19 67.9, 0.86 in-out-out SNCioo out-out ActLoopNT-out 6.0797 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -67.7, -68.85 APE9-dihe-na -109.26, -27.15 APE8-dihe-in -115.11, 101.44 APE8-rot-out 62.11 APE67-dihe-in -65.51, -20.35 -96.81, 16.0 APE12-dist-out 19.3179 APE11-dist-out 20.9352 APE10-dist-out 23.0855 APE9-dist-out 28.3652 T165E,S171E None None XRAY 1.827 0.189 0.215 C 331.0 292.0 0 28 28 0 [[17, 274]] 1.0 8fh4 Homo sapiens STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8FH4D Q92918 8 292 833.0 XXF:60401 Type1 Inactive DFGin 6.6457 14.0225 BLAminus -135.73, 170.9 66.66, 83.46 -93.58, 25.1 289.61, 94.72 -69.05, -41.66 in-in in 9.0222 Saltbr-in 2.7448 HRD-in -74.6, -51.27 71.89, -5.96 in-out-out SNCioo out-out ActLoopNT-out 6.1341 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -170.02 APE8-dihe-in -67.05, 131.5 APE8-rot-out 192.16 APE67-dihe-in -57.98, -30.82 -102.78, -3.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 27.4265 T165E,S171E None None XRAY 1.827 0.189 0.215 D 331.0 276.0 9 28 24 4 [[17, 274]] 1.0 8fh4 Homo sapiens STE_MAP4K1_HUMAN STE 6.2e-92 313.5 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9QT6A Q92918 6 292 833.0 A1JAF:301 Type1 Inactive DFGin 6.4629 13.7652 None -60.93, -35.58 -154.04, -176.9 -79.86, 1.42 63.88, 19.01 105.02, -157.57 out-out out 13.2797 Saltbr-out 10.7822 HRD-in -74.09, -55.53 70.27, 5.38 out-out-out SNCooo out-out ActLoopNT-out 7.5816 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -59.89, -40.77 APE9-dihe-na -92.18, -16.28 APE8-dihe-in -142.86, 74.69 APE8-rot-in 316.27 APE67-dihe-in -56.11, -27.62 -91.41, -1.8 APE12-dist-in 9.8088 APE11-dist-in 11.1344 APE10-dist-out 15.1534 APE9-dist-out 12.6983 T165E,S171E None None XRAY 1.76 0.198 0.226 A 294.0 285.0 2 28 28 0 [[17, 274]] 1.0 9qt6 Homo sapiens STE_MAP4K1_HUMAN STE 4.1e-92 314.1 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 8CIJA Q92918 14 294 833.0 USF:401 Type1 Inactive DFGout 11.2132 7.331 None -112.58, 122.54 -96.1, 115.56 -121.01, 999.0 297.98, 106.95 999.0, 999.0 out-out out 13.5351 Saltbr-out 11.7998 HRD-in -61.67, -48.53 69.18, 2.25 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na -87.98, 122.06 APE9-dihe-na 145.78, 142.84 APE8-dihe-in -120.8, 116.13 APE8-rot-in 320.07 APE67-dihe-in -58.16, -27.75 -31.5, -57.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 3.6814 None None None XRAY 2.821 0.239 0.266 A 307.0 264.0 17 28 16 12 [[17, 274]] 1.0 8cij Homo sapiens STE_MAP4K1_HUMAN STE 4.8e-92 313.9 1.0 256.0 256.0 154 155 156 158 160 46 62 66 134 136 135 137.0 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K4 M4K4_HUMAN 5DI1A O95819 13 309 1239.0 5DF:4000 Type1 Inactive DFGin 4.2602 13.3659 BLBplus -145.12, 159.02 72.53, 52.2 -89.55, 138.32 48.51, 95.38 -80.62, 999.0 in-out in 9.4027 Saltbr-out 3.985 HRD-in -61.2, -47.09 79.65, -23.06 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -102.21, 124.07 APE9-dihe-na -81.57, -147.04 APE8-dihe-in -74.95, 131.45 APE8-rot-out 195.98 APE67-dihe-in -46.35, -33.38 -85.44, -21.52 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.6024 None None None XRAY 2.9 0.2 0.249 A 310.0 285.0 12 28 16 12 [[25, 289]] 1.0 5di1 Homo sapiens STE_MAP4K4_HUMAN STE 1.3e-102 348.4 1.0 257.0 257.0 170 171 172 174 176 54 69 73 150 152 151 153.0 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
TKL ACVR1 ACVR1_HUMAN 3MTFA Q04771 203 498 509.0 A3F:1 Type1 Inactive DFGin 7.0905 13.2083 BLAminus -126.1, 157.67 76.9, 82.69 -86.05, 21.36 306.23, 175.03 -61.66, -24.97 in-out in 8.3313 Saltbr-out 4.1956 HRD-in -82.54, -58.57 79.29, -1.49 out-in-out SNCoio in-out ActLoopNT-in 2.9128 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -103.22, 162.67 APE9-dihe-na -69.88, 165.81 APE8-dihe-in -53.93, 121.99 APE8-rot-in 312.82 APE67-dihe-in -59.42, -28.32 -57.34, -37.41 APE12-dist-in 10.6706 APE11-dist-out 6.476 APE10-dist-out 9.4819 APE9-dist-in 4.0726 Q207D None None XRAY 2.15 0.185 0.244 A 301.0 296.0 0 32 32 0 [[207, 497]] 1.0 3mtf Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 3MTFB Q04771 202 499 509.0 A3F:501 Type1 Inactive DFGin 7.5781 13.3226 BLAminus -114.45, 160.06 82.35, 87.49 -104.83, 25.86 291.12, 164.81 -75.29, -13.54 in-out in 8.5 Saltbr-out 4.2324 HRD-in -82.5, -60.12 85.3, -4.39 out-in-out SNCoio in-out ActLoopNT-in 2.869 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -111.75, 153.3 APE9-dihe-na -57.45, 170.81 APE8-dihe-in -65.39, 131.64 APE8-rot-in 306.28 APE67-dihe-in -49.77, -35.33 -68.1, -43.23 APE12-dist-in 10.6109 APE11-dist-out 6.4527 APE10-dist-out 9.3963 APE9-dist-in 4.1192 Q207D None None XRAY 2.15 0.185 0.244 B 301.0 298.0 0 32 32 0 [[207, 497]] 1.0 3mtf Homo sapiens TKL_ACVR1_HUMAN TKL 1.9e-85 292.5 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 6EIXA Q04771 192 503 509.0 A3F:601 Type1 Inactive DFGin 7.3048 13.3822 BLAminus -122.31, 163.89 74.01, 85.68 -98.53, 23.31 310.02, 174.96 -66.89, -23.04 in-out in 9.0828 Saltbr-out 5.1598 HRD-in -81.6, -53.66 78.97, -2.54 out-in-out SNCoio in-out ActLoopNT-in 3.0232 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -113.45, 165.41 APE9-dihe-na -59.94, 163.8 APE8-dihe-in -59.76, 126.51 APE8-rot-in 307.55 APE67-dihe-in -58.05, -30.26 -58.58, -41.78 APE12-dist-in 10.589 APE11-dist-out 6.415 APE10-dist-out 9.3108 APE9-dist-in 3.8713 Q207E None None XRAY 2.3 0.191 0.249 A 340.0 312.0 0 32 32 0 [[207, 497]] 1.0 6eix Homo sapiens TKL_ACVR1_HUMAN TKL 2.9e-85 292.0 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL ACVR1 ACVR1_HUMAN 8PODA Q04771 172 498 509.0 7IO:60501,F:60502 Type1,Allosteric Inactive DFGin 7.1808 13.2482 BLAminus -129.23, 172.96 64.95, 88.23 -102.11, 21.22 307.17, 178.99 -69.46, -24.05 in-out in 8.7504 Saltbr-out 5.2405 HRD-in -77.46, -49.01 73.0, -1.63 out-in-out SNCoio in-out ActLoopNT-in 3.1049 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -104.74, 151.99 APE9-dihe-na -69.89, 170.49 APE8-dihe-in -67.7, 124.46 APE8-rot-in 304.29 APE67-dihe-in -63.94, -28.35 -69.6, -32.91 APE12-dist-in 10.7398 APE11-dist-out 6.5417 APE10-dist-out 9.7318 APE9-dist-in 4.6474 None None None XRAY 2.59 0.236 0.255 A 330.0 320.0 1 32 32 0 [[207, 497]] 1.0 8pod Homo sapiens TKL_ACVR1_HUMAN TKL 2.6e-85 292.1 2.0 267.0 266.0 353 354 355 357 359 235 248 252 333 335 334 336.0 403 385 380 379 378 377 376 375 374 284 Activin receptor type-1
TKL BRAF BRAF_HUMAN 4YHTA P15056 449 719 766.0 4EF:61002 Type1 Inactive DFGin 6.4399 13.919 BLAminus -130.91, -175.71 59.89, 88.64 -101.88, 16.92 281.61, 73.69 -54.19, -26.07 in-in in 8.6082 Saltbr-in 2.7306 HRD-in -63.73, -42.35 62.62, 3.64 in-in-out SNCiio in-out ActLoopNT-in 2.8806 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -6.83 APE8-dihe-in -100.18, 82.06 APE8-rot-in 287.27 APE67-dihe-in -63.55, -16.06 -74.16, -21.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.1095 I543T,I544N,I551T,L706T,L716T None None XRAY 3.05 0.2 0.233 A 272.0 256.0 15 30 17 13 [[457, 716]] 1.0 4yht Homo sapiens TKL_BRAF_HUMAN TKL 2.7e-84 288.8 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 4YHTB P15056 449 720 766.0 4EF:60802 Type1 Inactive DFGin 6.4052 13.9205 BLAminus -128.69, -172.56 54.11, 90.89 -102.92, 13.66 281.86, 71.12 -49.43, -28.96 in-in in 8.5831 Saltbr-in 2.7006 HRD-in -63.82, -42.99 62.91, 4.22 in-in-out SNCiio in-out ActLoopNT-in 2.8638 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -6.59 APE8-dihe-in -97.87, 80.96 APE8-rot-in 285.28 APE67-dihe-in -62.85, -18.47 -75.71, -20.06 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.0341 I543T,I544N,I551T,L706T,L716T None None XRAY 3.05 0.2 0.233 B 272.0 258.0 14 30 18 12 [[457, 716]] 1.0 4yht Homo sapiens TKL_BRAF_HUMAN TKL 2.7e-84 288.8 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 3Q96A P15056 449 722 766.0 0NF:1 Type2 Inactive DFGout 12.8873 10.6757 BBAminus -160.13, -172.44 -118.2, 91.86 -79.01, 12.35 294.04, 84.62 -59.8, 141.31 in-in in 8.3917 Saltbr-in 2.8554 HRD-in -57.31, -47.78 82.12, -11.82 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -115.71 APE8-rot-in 265.02 APE67-dihe-in -61.58, -24.04 -87.09, -36.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.1 0.233 0.288 A 282.0 253.0 21 30 12 18 [[457, 716]] 1.0 3q96 Homo sapiens TKL_BRAF_HUMAN TKL 8e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL BRAF BRAF_HUMAN 3Q96B P15056 449 720 766.0 0NF:1 Type2 Inactive DFGout 12.3376 11.6545 BBAminus -159.06, -168.23 -117.43, 81.54 -79.68, 17.57 296.0, 82.29 -26.83, 105.54 in-in in 8.5859 Saltbr-in 3.1759 HRD-in -76.92, -42.58 73.28, -12.97 in-out-out SNCioo out-out ActLoopNT-out 18.4896 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 159.44 APE8-dihe-in -92.55, 126.53 APE8-rot-in 290.06 APE67-dihe-in -62.77, -20.3 -102.35, -28.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.2315 None None None XRAY 3.1 0.233 0.288 B 282.0 262.0 10 30 20 10 [[457, 716]] 1.0 3q96 Homo sapiens TKL_BRAF_HUMAN TKL 8e-82 280.7 4.0 266.0 263.0 593 594 595 597 599 483 501 505 573 575 574 576.0 638 623 618 617 616 615 614 613 612 530 Serine/threonine-protein kinase B-raf
TKL IRAK4 IRAK4_HUMAN 4YP8A Q9NWZ3 164 459 460.0 4GF:501 Type1 Active DFGin 6.842 14.1629 BLAminus -130.64, 178.89 61.7, 76.88 -103.53, 25.67 310.66, 96.36 -67.74, -31.55 in-in in 8.7784 Saltbr-in 3.5486 HRD-in -57.79, -50.73 76.7, -3.88 in-in-in SNCiii in-in ActLoopNT-in 2.7748 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.21, 150.97 APE9-dihe-na 140.01, -173.97 APE8-dihe-in -103.61, 115.43 APE8-rot-in 309.9 APE67-dihe-in -66.28, -16.88 -42.43, -50.13 APE12-dist-in 10.0082 APE11-dist-in 11.614 APE10-dist-in 6.3264 APE9-dist-in 3.9176 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 A 301.0 287.0 9 30 26 4 [[183, 456]] 1.0 4yp8 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4YP8B Q9NWZ3 161 459 460.0 4GF:501 Type1 Inactive DFGin 6.9172 14.4445 BLAminus -129.86, 179.56 60.17, 77.95 -104.22, 26.32 310.53, 95.0 -66.78, -33.18 in-out in 8.6851 Saltbr-out 3.9622 HRD-in -57.85, -50.75 76.66, -4.15 out-in-in SNCoii in-in ActLoopNT-in 2.8535 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.74, 150.82 APE9-dihe-na 140.12, -173.75 APE8-dihe-in -103.4, 115.49 APE8-rot-in 310.63 APE67-dihe-in -65.34, -17.03 -41.64, -51.23 APE12-dist-in 10.0453 APE11-dist-in 11.5809 APE10-dist-in 6.3191 APE9-dist-in 3.9048 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 B 301.0 281.0 18 30 24 6 [[183, 456]] 1.0 4yp8 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4YP8C Q9NWZ3 164 460 460.0 4GF:501 Type1 Inactive DFGin 6.8212 14.4085 BLAminus -129.81, 179.51 59.35, 79.05 -103.24, 26.6 309.61, 96.69 -66.38, -34.02 in-out in 8.8507 Saltbr-out 4.6837 HRD-in -59.31, -50.52 77.45, -5.42 out-in-in SNCoii in-in ActLoopNT-in 2.7895 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -122.88, 150.51 APE9-dihe-na 141.79, -174.18 APE8-dihe-in -103.25, 114.63 APE8-rot-in 311.45 APE67-dihe-in -64.61, -17.76 -41.38, -51.75 APE12-dist-in 10.1488 APE11-dist-in 11.6263 APE10-dist-in 6.34 APE9-dist-in 3.9449 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 C 301.0 290.0 7 30 26 4 [[183, 456]] 1.0 4yp8 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 4YP8D Q9NWZ3 164 459 460.0 4GF:501 Type1 Inactive DFGin 6.8543 14.3193 BLAminus -129.62, 178.91 61.84, 77.53 -103.67, 26.43 310.15, 95.74 -66.28, -34.21 in-out in 8.9151 Saltbr-out 3.8024 HRD-in -59.75, -49.91 75.93, -3.95 out-in-in SNCoii in-in ActLoopNT-in 2.7897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -123.59, 153.02 APE9-dihe-na 138.42, -174.86 APE8-dihe-in -103.4, 114.55 APE8-rot-in 310.75 APE67-dihe-in -64.11, -17.03 -41.21, -51.68 APE12-dist-in 10.0152 APE11-dist-in 11.5854 APE10-dist-in 6.3272 APE9-dist-in 3.9224 None TPO342,TPO345,SEP346 TPO342,TPO345,SEP346 XRAY 2.641 0.193 0.219 D 301.0 288.0 8 30 26 4 [[183, 456]] 1.0 4yp8 Homo sapiens TKL_IRAK4_HUMAN TKL 4.1e-84 288.2 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6LXYA Q9NWZ3 163 458 460.0 EXF:501 Type1 Inactive DFGin 6.9967 14.0491 BLAminus -130.85, 177.02 62.25, 85.69 -105.57, 13.21 307.3, 97.03 -58.17, -30.36 in-out in 8.9293 Saltbr-out 5.3622 HRD-in -67.47, -54.1 77.02, 0.48 out-in-in SNCoii in-in ActLoopNT-in 2.8192 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.95, 147.66 APE9-dihe-na 135.07, -175.38 APE8-dihe-in -106.14, 112.07 APE8-rot-in 312.29 APE67-dihe-in -59.29, -20.88 -52.35, -43.4 APE12-dist-in 10.1915 APE11-dist-in 11.7043 APE10-dist-in 6.4389 APE9-dist-in 4.3573 None TPO345,SEP346 TPO345,SEP346 XRAY 2.19 0.202 0.231 A 305.0 294.0 2 30 28 2 [[183, 456]] 1.0 6lxy Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6LXYB Q9NWZ3 163 459 460.0 EXF:502 Type1 None DFGin 6.9731 14.1366 BLAminus -129.45, 177.84 61.74, 86.54 -106.07, 12.43 306.08, 97.48 -57.61, -29.04 in-none in 9.0982 Saltbr-none 999.0 HRD-in -68.65, -53.21 75.68, 1.0 none-in-in SNCnii in-in ActLoopNT-in 2.8068 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.47, 149.33 APE9-dihe-na 135.3, -175.41 APE8-dihe-in -105.49, 112.4 APE8-rot-in 312.11 APE67-dihe-in -59.55, -21.17 -51.5, -42.55 APE12-dist-in 10.1894 APE11-dist-in 11.6864 APE10-dist-in 6.444 APE9-dist-in 4.3325 None TPO345,SEP346 TPO345,SEP346 XRAY 2.19 0.202 0.231 B 305.0 297.0 0 30 30 0 [[183, 456]] 1.0 6lxy Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6LXYD Q9NWZ3 162 459 460.0 EXF:502 Type1 Inactive DFGin 7.0024 14.1156 BLAminus -130.62, 177.55 62.4, 85.91 -106.35, 12.8 307.19, 98.16 -58.64, -30.18 in-out in 8.9428 Saltbr-out 5.3537 HRD-in -67.38, -53.42 77.14, -1.48 out-in-in SNCoii in-in ActLoopNT-in 2.7863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.01, 149.8 APE9-dihe-na 134.89, -175.28 APE8-dihe-in -104.95, 111.45 APE8-rot-in 311.34 APE67-dihe-in -58.57, -21.72 -44.58, -48.25 APE12-dist-in 10.314 APE11-dist-in 11.9545 APE10-dist-in 6.613 APE9-dist-in 4.2536 None TPO345,SEP346 TPO345,SEP346 XRAY 2.19 0.202 0.231 D 305.0 293.0 5 30 25 5 [[183, 456]] 1.0 6lxy Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL IRAK4 IRAK4_HUMAN 6LXYE Q9NWZ3 164 458 460.0 EXF:502 Type1 Inactive DFGin 6.9536 14.1587 BLAminus -130.3, 176.57 62.62, 85.73 -105.89, 13.23 306.79, 97.59 -58.45, -29.69 in-out in 8.9309 Saltbr-out 5.3907 HRD-in -66.96, -52.89 76.03, -0.37 out-in-in SNCoii in-in ActLoopNT-in 2.7953 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -125.25, 150.73 APE9-dihe-na 134.77, -173.9 APE8-dihe-in -105.72, 111.9 APE8-rot-in 311.85 APE67-dihe-in -56.93, -22.86 -45.56, -48.25 APE12-dist-in 10.3091 APE11-dist-in 11.9048 APE10-dist-in 6.6072 APE9-dist-in 4.2918 None TPO345,SEP346 TPO345,SEP346 XRAY 2.19 0.202 0.231 E 305.0 288.0 7 30 23 7 [[183, 456]] 1.0 6lxy Homo sapiens TKL_IRAK4_HUMAN TKL 4.3e-84 288.1 5.0 266.0 262.0 328 329 330 332 334 213 233 237 308 310 309 311.0 369 358 353 352 351 350 349 348 347 263 Interleukin-1 receptor-associated kinase 4
TKL MAP3K12 M3K12_HUMAN 5CEQA Q12852 117 398 859.0 50F:4000 Type1 Inactive DFGin 6.2846 14.1433 BLBplus -139.34, 175.24 65.23, 33.46 -103.17, 163.52 57.07, 90.2 71.88, 999.0 out-na out 13.9369 Saltbr-na 13.2447 HRD-in -61.44, -57.14 79.98, -14.5 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na -71.43, -48.01 APE9-dihe-na -72.5, -0.08 APE8-dihe-out -118.56, -4.99 APE8-rot-out 184.08 APE67-dihe-in -55.04, -30.89 -63.03, -27.19 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.1318 None None None XRAY 1.911 0.171 0.218 A 300.0 269.0 13 27 14 13 [[118, 372]] 1.0 5ceq Homo sapiens TKL_MAP3K12_HUMAN MAP3K123 1.5e-137 462.8 1.0 254.0 254.0 253 254 255 257 259 152 161 165 233 235 234 236.0 292 280 275 274 273 272 271 270 269 191 Mitogen-activated protein kinase kinase kinase 12
TKL MAP3K7 M3K7_HUMAN 5J9LA O43318 31 496 606.0 6HF:60501 Type1 Inactive DFGout 12.964 7.5747 None -126.7, 106.14 -55.49, -39.75 -39.65, 999.0 105.32, 93.88 999.0, 999.0 in-out in 9.6191 Saltbr-out 4.6621 HRD-in -64.53, -55.8 74.12, -2.79 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 124.52 APE8-dihe-out -91.5, 21.0 APE8-rot-in 299.75 APE67-dihe-in -63.93, -32.31 -64.12, -36.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.6997 None None None XRAY 2.752 0.214 0.243 A 307.0 253.0 20 25 11 14 [[36, 286]] 1.0 5j9l Homo sapiens TKL_MAP3K7_HUMAN TKL 3.7e-74 255.5 2.0 266.0 265.0 174 175 176 178 180 63 77 81 153 155 154 156.0 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
TKL RIPK1 RIPK1_HUMAN 7FCZA Q13546 10 294 671.0 3IF:301 Type3 Inactive DFGout 13.8651 10.3793 BBAminus -121.61, 171.92 -133.79, 66.08 -70.41, -22.3 302.99, 177.02 -85.6, 3.29 out-out out 15.0017 Saltbr-out 12.8499 HRD-in -69.8, -48.63 73.26, -13.72 out-out-out SNCooo out-out ActLoopNT-out 6.0735 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 77.72 APE8-dihe-in -67.19, 127.43 APE8-rot-in 294.95 APE67-dihe-in -62.33, -29.47 -101.92, 1.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.4756 C34A,C127A,C233A,C240A None None XRAY 2.21 0.236 0.257 A 297.0 248.0 37 41 23 18 [[17, 287]] 1.0 7fcz Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6.0 265.0 260.0 155 156 157 159 161 45 63 67 135 137 136 138.0 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL RIPK1 RIPK1_HUMAN 7FCZB Q13546 7 294 671.0 3IF:301 Type3 Inactive DFGout 13.9133 10.0278 BBAminus -118.21, 174.22 -136.13, 64.53 -68.29, -24.74 303.09, 178.58 -83.09, -0.43 out-out out 14.1894 Saltbr-out 12.5753 HRD-in -73.47, -53.47 80.61, -17.48 out-out-out SNCooo out-out ActLoopNT-out 6.1388 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 101.37 APE8-dihe-in -64.4, 143.44 APE8-rot-out 179.16 APE67-dihe-in -62.08, -29.26 -100.06, -1.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.6339 C34A,C127A,C233A,C240A None None XRAY 2.21 0.236 0.257 B 297.0 263.0 25 41 24 17 [[17, 287]] 1.0 7fcz Homo sapiens TKL_RIPK1_HUMAN TKL 1.3e-72 250.5 6.0 265.0 260.0 155 156 157 159 161 45 63 67 135 137 136 138.0 210 196 191 190 189 188 187 186 185 93 Receptor-interacting serine/threonine-protein kinase 1
TKL TGFBR1 TGFR1_HUMAN 2WOUA P36897 200 496 503.0 ZZF:61500 Type1 Active DFGin 6.1243 13.0393 BLAminus -133.49, -169.53 51.05, 62.4 -92.04, 13.34 298.31, 178.69 -62.77, -27.98 in-in in 7.5857 Saltbr-in 2.7517 HRD-in -65.52, -56.03 81.95, -3.97 in-in-in SNCiii in-in ActLoopNT-in 3.039 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -95.77, -22.31 APE9-dihe-na -79.77, -172.15 APE8-dihe-in -73.94, 125.36 APE8-rot-in 306.35 APE67-dihe-in -52.11, -29.79 -56.64, -45.19 APE12-dist-in 13.0776 APE11-dist-in 11.9354 APE10-dist-in 6.0414 APE9-dist-in 3.6288 None None None XRAY 2.3 0.229 0.302 A 306.0 297.0 0 32 32 0 [[205, 494]] 1.0 2wou Homo sapiens TKL_TGFBR1_HUMAN TKL 3.3e-85 291.7 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 3FAAA P36897 171 500 503.0 55F:601 Type1 Active DFGin 5.9037 13.0472 BLAminus -165.74, 163.41 74.29, 54.12 -79.67, 24.05 317.06, 176.62 -56.68, -51.28 in-in in 8.0011 Saltbr-in 2.9364 HRD-in -45.11, -27.8 52.25, 11.68 in-in-in SNCiii in-in ActLoopNT-in 3.1109 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.43, -171.19 APE9-dihe-na 80.03, 171.79 APE8-dihe-in -67.98, 121.11 APE8-rot-in 302.91 APE67-dihe-in -99.71, -73.49 -46.09, -5.99 APE12-dist-in 11.6243 APE11-dist-in 11.9673 APE10-dist-in 6.0149 APE9-dist-in 4.0613 None None None XRAY 3.35 0.228 0.271 A 342.0 328.0 2 32 30 2 [[205, 494]] 1.0 3faa Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 3FAAB P36897 171 501 503.0 55F:601 Type1 Active DFGin 6.0174 13.3063 BLAminus -136.45, -176.24 60.04, 54.86 -81.47, 12.98 307.95, 5.19 -52.57, -45.29 in-in in 8.0996 Saltbr-in 3.0373 HRD-in -75.89, -39.75 60.74, 14.93 in-in-in SNCiii in-in ActLoopNT-in 3.1146 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -120.32, 175.24 APE9-dihe-na 101.52, 166.7 APE8-dihe-in -70.87, 127.35 APE8-rot-in 315.28 APE67-dihe-in -36.34, -44.33 -43.95, -69.54 APE12-dist-in 11.9404 APE11-dist-in 11.9996 APE10-dist-in 6.3733 APE9-dist-in 4.0844 None None None XRAY 3.35 0.228 0.271 B 342.0 324.0 7 32 29 3 [[205, 494]] 1.0 3faa Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 3FAAC P36897 171 500 503.0 55F:601 Type1 Inactive DFGin 6.142 13.1414 BLAminus -126.27, 176.42 50.71, 78.49 -102.58, 30.06 320.3, 19.34 -66.31, -17.95 in-in in 7.9903 Saltbr-in 2.6623 HRD-in -67.56, -21.99 46.1, 19.37 in-in-out SNCiio in-out ActLoopNT-in 2.947 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiii APE10-dihe-na -120.66, 131.05 APE9-dihe-na 148.7, 175.0 APE8-dihe-in -102.93, 87.73 APE8-rot-in 305.5 APE67-dihe-out -28.83, -55.82 5.18, -84.04 APE12-dist-in 11.4809 APE11-dist-in 12.1489 APE10-dist-in 6.2467 APE9-dist-in 4.208 None None None XRAY 3.35 0.228 0.271 C 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 3faa Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 3FAAD P36897 171 500 503.0 55F:601 Type1 Active DFGin 6.2595 13.1679 BLAminus -151.5, 176.63 62.94, 64.2 -90.99, 26.98 302.19, 4.38 -66.56, -19.34 in-in in 7.8095 Saltbr-in 2.7451 HRD-in -63.44, -55.82 78.14, 1.44 in-in-in SNCiii in-in ActLoopNT-in 2.8034 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.86, 174.28 APE9-dihe-na 87.09, 173.14 APE8-dihe-in -66.87, 116.28 APE8-rot-in 325.42 APE67-dihe-in -60.47, -38.15 -48.63, -36.35 APE12-dist-in 11.7136 APE11-dist-in 11.8944 APE10-dist-in 6.3705 APE9-dist-in 4.2294 None None None XRAY 3.35 0.228 0.271 D 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 3faa Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR1 TGFR1_HUMAN 3FAAE P36897 171 500 503.0 55F:601 Type1 Active DFGin 6.355 13.3659 BLAminus -131.48, -168.05 37.37, 86.28 -107.7, 26.02 296.92, 176.17 -65.92, -19.56 in-in in 7.7814 Saltbr-in 3.0945 HRD-in -66.77, -57.93 79.95, 12.98 in-in-in SNCiii in-in ActLoopNT-in 2.8502 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.13, 169.87 APE9-dihe-na 90.72, 172.5 APE8-dihe-in -64.72, 129.04 APE8-rot-in 310.98 APE67-dihe-in -56.46, -40.64 -59.57, -42.14 APE12-dist-in 11.9901 APE11-dist-in 12.0559 APE10-dist-in 6.5703 APE9-dist-in 3.9816 None None None XRAY 3.35 0.228 0.271 E 342.0 330.0 0 32 32 0 [[205, 494]] 1.0 3faa Homo sapiens TKL_TGFBR1_HUMAN TKL 4.9e-85 291.2 3.0 266.0 264.0 350 351 352 354 356 232 245 249 330 332 331 333.0 400 382 377 376 375 374 373 372 371 281 TGF-beta receptor type-1
TKL TGFBR2 TGFR2_HUMAN 7DV6A P37173 240 543 567.0 HJF:9000 Type1 Active DFGin 7.1311 13.4318 BLAminus -156.15, -164.95 57.9, 60.45 -93.44, 15.51 294.56, 110.64 -56.6, -36.89 in-in in 7.4443 Saltbr-in 2.6595 HRD-in -60.78, -51.79 74.77, -4.11 in-in-in SNCiii in-in ActLoopNT-in 2.8603 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -118.14, 141.57 APE9-dihe-na 113.33, -173.4 APE8-dihe-in -82.04, 128.94 APE8-rot-in 303.35 APE67-dihe-in -55.96, -36.36 -60.86, -38.17 APE12-dist-in 11.5078 APE11-dist-in 11.8903 APE10-dist-in 6.0465 APE9-dist-in 3.9117 E431A,R433A,E485A,K488A,R493A,R495A None None XRAY 2.39 0.163 0.224 A 323.0 304.0 0 32 32 0 [[244, 540]] 1.0 7dv6 Homo sapiens TKL_TGFBR2_HUMAN TKL 2.1e-77 266.2 2.0 266.0 265.0 396 397 398 400 402 277 290 294 376 378 377 379.0 446 428 423 422 421 420 419 418 417 326 TGF-beta receptor type-2
TYR ALK ALK_HUMAN 4CCUA Q9UM73 1093 1402 1620.0 AWF:1500 Type1 Inactive DFGin 6.0199 14.6231 ABAminus -118.73, -9.8 -132.17, 139.04 -133.56, 37.48 295.42, 86.35 -74.53, -27.89 in-out in 8.2766 Saltbr-out 4.6887 HRD-in -77.94, -47.73 82.62, -10.67 out-out-out SNCooo out-out ActLoopNT-out 6.8034 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -110.98, -27.23 APE9-dihe-in -56.62, 135.11 APE8-dihe-in -75.38, 65.75 APE8-rot-na 29.29 APE67-dihe-in -70.29, -14.23 -60.1, -29.45 APE12-dist-na 14.5251 APE11-dist-na 15.1704 APE10-dist-na 10.0283 APE9-dist-in 7.7958 None None None XRAY 2.0 0.202 0.233 A 327.0 293.0 17 30 24 6 [[1116, 1385]] 1.0 4ccu Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 4FNZA Q9UM73 1093 1402 1620.0 NZF:1501 Type1 Inactive DFGin 5.291 12.7997 ABAminus -135.46, 12.02 -152.76, 153.63 -83.97, -38.55 283.31, 122.35 73.66, 999.0 in-in in 8.5004 Saltbr-in 2.8123 HRD-in -72.66, -49.3 78.9, -9.45 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -97.65, -24.93 APE9-dihe-in -50.61, 132.71 APE8-dihe-in -79.34, 69.48 APE8-rot-na 27.73 APE67-dihe-in -74.42, -13.21 -56.44, -36.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8304 C1097S None None XRAY 2.6 0.202 0.261 A 327.0 287.0 23 30 15 15 [[1116, 1385]] 1.0 4fnz Homo sapiens TYR_ALK_HUMAN TYR 1.4e-90 309.1 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 4DCEA Q9UM73 1093 1402 1620.0 0JF:1501 Type1 Inactive DFGin 5.6296 13.8228 None -137.27, 16.47 -161.52, 152.14 -94.73, 164.26 291.72, 122.64 -76.17, 999.0 in-in in 8.4822 Saltbr-in 2.8829 HRD-in -75.4, -48.78 85.77, -10.33 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -96.83, -20.84 APE9-dihe-in -55.51, 136.7 APE8-dihe-in -77.28, 70.08 APE8-rot-na 28.6 APE67-dihe-in -68.31, -8.92 -56.77, -41.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.9739 C1097S None None XRAY 2.03 0.211 0.256 A 333.0 288.0 22 30 16 14 [[1116, 1385]] 1.0 4dce Homo sapiens TYR_ALK_HUMAN TYR 1.5e-90 309.0 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR ALK ALK_HUMAN 4DCEB Q9UM73 1094 1402 1620.0 0JF:1501 Type1 Inactive DFGin 5.7474 13.6282 None -141.04, 18.73 -165.26, 150.02 -96.5, 167.37 286.77, 120.17 -70.38, 999.0 in-in in 8.5634 Saltbr-in 2.9896 HRD-in -72.56, -48.26 83.87, -14.3 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -96.41, -12.56 APE9-dihe-in -59.98, 136.0 APE8-dihe-in -80.48, 64.18 APE8-rot-na 31.8 APE67-dihe-in -66.1, -14.3 -52.07, -41.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.7127 C1097S None None XRAY 2.03 0.211 0.256 B 333.0 284.0 25 30 15 15 [[1116, 1385]] 1.0 4dce Homo sapiens TYR_ALK_HUMAN TYR 1.5e-90 309.0 1.0 260.0 260.0 1269 1270 1271 1273 1275 1150 1167 1171 1246 1248 1247 1249.0 1311 1299 1294 1293 1292 1291 1290 1289 1288 1197 ALK tyrosine kinase receptor
TYR BTK BTK_HUMAN 5FBNC Q06187 395 658 659.0 5WF:701,5WE:702 Type1.5_Front,Allosteric Inactive DFGin 6.2343 13.4854 BLBplus -138.97, 172.93 64.41, 21.2 -64.91, 134.85 43.34, 89.93 78.28, -17.1 out-out out 15.0072 Saltbr-out 15.714 HRD-in -67.81, -54.89 86.66, -24.42 out-out-out SNCooo out-out ActLoopNT-out 8.1944 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out 143.31, -31.01 APE9-dihe-in -63.12, 135.49 APE8-dihe-in -76.38, 65.1 APE8-rot-na 32.35 APE67-dihe-in -72.98, -10.12 -50.46, -47.16 APE12-dist-na 999.0 APE11-dist-na 17.8308 APE10-dist-na 12.6083 APE9-dist-out 8.1809 None None None XRAY 1.8 0.182 0.226 C 271.0 256.0 8 29 21 8 [[402, 653]] 1.0 5fbn Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 5FBND Q06187 394 658 659.0 5WF:702,5WE:703,5WE:704,5WE:705 Type1.5_Front,Allosteric,Allosteric,Allosteric Inactive DFGin 6.2504 13.4724 BLBplus -137.76, 172.64 65.66, 19.16 -62.24, 135.48 45.56, 88.91 74.32, -16.76 out-out out 15.0558 Saltbr-out 15.7515 HRD-in -65.32, -54.88 86.04, -26.38 out-out-none SNCoon out-none ActLoopNT-out 8.1947 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 136.18 APE8-dihe-in -78.24, 64.6 APE8-rot-na 31.95 APE67-dihe-in -74.36, -8.3 -50.81, -46.27 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.8979 None None None XRAY 1.8 0.182 0.226 D 271.0 255.0 10 29 19 10 [[402, 653]] 1.0 5fbn Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.8 1.0 258.0 258.0 538 539 540 542 544 430 445 449 518 520 519 521.0 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR DDR1 DDR1_HUMAN 5SAUA Q08345 604 912 913.0 1IF:61000 Type2 Inactive DFGout 12.6278 9.6718 BBAminus -137.39, -170.54 -153.95, 108.1 -100.48, 5.9 289.81, 101.12 83.39, -174.73 in-in in 8.355 Saltbr-in 2.8692 HRD-in -71.66, -48.67 82.15, -10.52 in-out-in SNCioi out-in ActLoopNT-out 18.1388 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -69.56, 139.94 APE9-dihe-in -129.66, 123.98 APE8-dihe-in -80.56, 70.77 APE8-rot-na 35.49 APE67-dihe-in -73.85, -9.33 -63.13, -31.85 APE12-dist-na 13.3308 APE11-dist-na 10.3117 APE10-dist-na 5.8844 APE9-dist-in 7.5547 None None None XRAY 1.8 0.201 0.231 A 321.0 287.0 16 30 30 0 [[610, 907]] 1.0 5sau Homo sapiens TYR_DDR1_HUMAN TYR 1.4e-92 315.7 1.0 260.0 260.0 783 784 785 787 789 655 672 676 763 765 764 766.0 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR EPHA2 EPHA2_HUMAN 8BOCA P29317 605 888 976.0 QUF:1001 Type2 Inactive DFGout 13.5834 10.813 BBAminus -139.62, -179.28 -151.24, 106.28 -78.98, -6.2 302.64, 171.21 84.05, 5.79 in-in in 8.8689 Saltbr-in 3.5006 HRD-in -70.68, -54.7 83.35, -19.69 in-out-in SNCioi out-in ActLoopNT-out 12.2476 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -113.53, 160.37 APE9-dihe-in -116.01, 148.45 APE8-dihe-in -79.02, 97.78 APE8-rot-na 34.23 APE67-dihe-in -77.84, -8.8 -56.96, -40.4 APE12-dist-na 12.8439 APE11-dist-na 9.3252 APE10-dist-na 7.8923 APE9-dist-in 5.837 None None None XRAY 1.9 0.248 0.286 A 306.0 271.0 13 31 31 0 [[613, 873]] 1.0 8boc Homo sapiens TYR_EPHA2_HUMAN TYR 5.5e-108 366.1 2.0 261.0 260.0 756 757 758 760 762 646 663 667 736 738 737 739.0 799 787 782 781 780 779 778 777 776 693 Ephrin type-A receptor 2
TYR EPHB4 EPHB4_HUMAN 2X9FA P54760 608 888 987.0 X9F:1889 Type1 Inactive DFGin 6.2077 14.3304 BLBminus -134.1, -172.08 65.01, 71.96 -106.66, 162.22 301.36, 107.12 163.16, 158.85 in-in in 7.543 Saltbr-in 2.7028 HRD-in -73.92, -48.13 77.71, -16.54 in-out-in SNCioi out-in ActLoopNT-out 9.7905 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -102.56, 149.08 APE9-dihe-in -55.67, 129.32 APE8-dihe-in -83.14, 89.74 APE8-rot-na 29.6 APE67-dihe-in -62.34, -22.56 -52.45, -48.78 APE12-dist-na 8.3626 APE11-dist-na 11.4167 APE10-dist-na 15.4162 APE9-dist-in 6.3395 Y774E None None XRAY 1.75 0.159 0.194 A 302.0 265.0 16 33 20 13 [[615, 876]] 1.0 2x9f Homo sapiens TYR_EPHB4_HUMAN TYR 3.9e-104 353.5 2.0 261.0 260.0 757 758 759 761 763 647 664 668 737 739 738 740.0 802 790 785 784 783 782 781 780 779 694 Ephrin type-B receptor 4
TYR FGFR1 FGFR1_HUMAN 9UHIA P11362 458 764 822.0 A1EPF:60801 Type1 Inactive DFGin 5.058 13.4362 BLAplus -111.91, 163.26 62.65, 26.85 -80.22, -19.74 58.59, 88.0 -94.12, 4.52 in-in in 8.2512 Saltbr-in 2.8878 HRD-in -74.14, -50.3 78.02, -11.1 in-out-out SNCioo out-out ActLoopNT-out 7.5114 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -88.77, 149.44 APE9-dihe-in -108.01, 98.39 APE8-dihe-out -63.46, -15.87 APE8-rot-na 3.35 APE67-dihe-in -71.69, -10.38 -55.45, -26.93 APE12-dist-na 17.216 APE11-dist-na 19.6718 APE10-dist-na 16.6848 APE9-dist-out 11.0826 None None None XRAY 1.76 0.163 0.197 A 310.0 307.0 0 30 30 0 [[478, 756]] 1.0 9uhi Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 9UHIB P11362 458 763 822.0 A1EPF:60801 Type1 Inactive DFGin 5.2132 12.7377 BLAplus -108.15, 164.77 66.41, 24.28 -84.34, -17.16 58.96, 83.83 -89.87, -8.4 in-in in 7.7681 Saltbr-in 3.4492 HRD-in -77.39, -52.67 76.89, -15.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -74.45, 132.66 APE9-dihe-in -102.74, 93.19 APE8-dihe-out -60.68, -21.29 APE8-rot-na 332.28 APE67-dihe-in -72.11, -2.38 -56.87, -27.58 APE12-dist-na 17.3515 APE11-dist-na 20.6822 APE10-dist-na 16.9654 APE9-dist-out 11.3637 None None None XRAY 1.76 0.163 0.197 B 310.0 286.0 20 30 23 7 [[478, 756]] 1.0 9uhi Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 3C4FA P11362 464 765 822.0 C4F:1 Type1.5_Back Inactive DFGin 5.1138 13.3182 BLAplus -110.44, 159.78 58.59, 34.58 -81.02, -11.31 51.22, 81.2 -119.48, 23.64 in-out in 7.8662 Saltbr-out 4.6321 HRD-in -67.82, -57.48 84.79, -17.47 out-out-out SNCooo out-out ActLoopNT-out 9.0691 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -97.31, 173.6 APE9-dihe-in -111.71, 110.92 APE8-dihe-out -49.57, -28.9 APE8-rot-na 335.93 APE67-dihe-in -76.49, -6.67 -57.78, -16.15 APE12-dist-na 19.2924 APE11-dist-na 21.1206 APE10-dist-na 19.3954 APE9-dist-out 11.7567 C488A None None XRAY 2.07 0.213 0.264 A 302.0 290.0 12 30 30 0 [[478, 756]] 1.0 3c4f Homo sapiens TYR_FGFR1_HUMAN TYR 1.3e-104 355.0 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 3C4FB P11362 464 765 822.0 C4F:2 Type1.5_Back Inactive DFGin 5.1863 13.0956 BLAplus -113.87, 161.2 54.21, 44.76 -88.95, -14.38 49.14, 89.01 -114.94, 24.21 in-in in 7.8308 Saltbr-in 3.2478 HRD-in -69.91, -54.09 86.4, -33.67 in-out-out SNCioo out-out ActLoopNT-out 8.9335 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -106.54, 164.12 APE9-dihe-in -103.97, 111.75 APE8-dihe-out -49.46, -30.24 APE8-rot-na 330.07 APE67-dihe-in -74.8, -7.14 -56.82, -17.81 APE12-dist-na 19.3702 APE11-dist-na 21.2959 APE10-dist-na 19.6706 APE9-dist-out 11.6434 C488A None None XRAY 2.07 0.213 0.264 B 302.0 290.0 12 30 30 0 [[478, 756]] 1.0 3c4f Homo sapiens TYR_FGFR1_HUMAN TYR 1.3e-104 355.0 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 5EW8A P11362 464 765 822.0 5SF:803 Type1.5_Back Inactive DFGin 4.9481 13.2646 BLAplus -106.94, 161.6 53.73, 34.99 -75.93, -13.84 56.0, 83.89 -112.21, 7.75 in-in in 7.9544 Saltbr-in 2.8007 HRD-in -68.23, -51.53 79.48, -14.26 in-out-out SNCioo out-out ActLoopNT-out 9.0673 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.87, 162.8 APE9-dihe-in -100.01, 112.78 APE8-dihe-out -57.6, -21.18 APE8-rot-na 333.77 APE67-dihe-in -70.4, -6.07 -56.33, -25.26 APE12-dist-na 19.3705 APE11-dist-na 20.7434 APE10-dist-na 19.2162 APE9-dist-out 11.8815 None None None XRAY 1.63 0.186 0.206 A 309.0 291.0 11 30 30 0 [[478, 756]] 1.0 5ew8 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 5EW8B P11362 461 765 822.0 5SF:802 Type1.5_Back Inactive DFGin 5.0015 13.1238 BLAplus -109.75, 160.16 55.05, 34.73 -78.35, -12.87 54.65, 85.31 -106.64, 12.94 in-in in 7.8796 Saltbr-in 2.8072 HRD-in -67.52, -52.32 78.89, -12.97 in-out-out SNCioo out-out ActLoopNT-out 8.3799 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -104.81, 162.42 APE9-dihe-in -99.2, 111.94 APE8-dihe-out -57.42, -21.49 APE8-rot-na 334.53 APE67-dihe-in -69.99, -6.88 -56.65, -24.13 APE12-dist-na 19.9019 APE11-dist-na 21.1689 APE10-dist-na 19.6545 APE9-dist-out 11.7665 None None None XRAY 1.63 0.186 0.206 B 309.0 290.0 15 30 28 2 [[478, 756]] 1.0 5ew8 Homo sapiens TYR_FGFR1_HUMAN TYR 1.4e-104 354.9 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 7WCLA P11362 459 764 822.0 8ZF:60801 Type1.5_Back Inactive DFGin 5.0323 13.5114 BLAplus -110.65, 158.43 54.71, 42.71 -89.1, -11.93 53.54, 87.56 -114.63, 26.86 in-in in 8.2337 Saltbr-in 2.9434 HRD-in -65.51, -45.04 70.13, -0.28 in-out-out SNCioo out-out ActLoopNT-out 7.9796 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -98.05, 142.67 APE9-dihe-in -99.82, 98.85 APE8-dihe-out -66.04, -10.56 APE8-rot-na 23.45 APE67-dihe-in -75.78, -2.11 -60.96, -29.19 APE12-dist-na 16.7251 APE11-dist-na 19.0668 APE10-dist-na 16.2264 APE9-dist-out 11.2235 C584S None None XRAY 2.495 0.195 0.23 A 310.0 306.0 0 30 30 0 [[478, 756]] 1.0 7wcl Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR1 FGFR1_HUMAN 7WCLB P11362 458 763 822.0 8ZF:60801 Type1.5_Back Inactive DFGin 5.6863 13.2974 BLAplus -116.0, 164.36 53.53, 38.11 -89.51, -19.74 50.41, 88.95 -102.65, 11.92 in-in in 8.3808 Saltbr-in 2.8041 HRD-in -77.55, -44.61 69.5, -1.67 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -124.03, 166.88 APE9-dihe-in -112.63, 116.79 APE8-dihe-out -58.21, -18.36 APE8-rot-na 340.54 APE67-dihe-in -81.23, 2.92 -65.55, -20.31 APE12-dist-na 18.6 APE11-dist-na 21.6055 APE10-dist-na 19.4985 APE9-dist-out 11.4021 C584S None None XRAY 2.495 0.195 0.23 B 310.0 285.0 21 30 22 8 [[478, 756]] 1.0 7wcl Homo sapiens TYR_FGFR1_HUMAN TYR 2.1e-104 354.4 1.0 260.0 260.0 640 641 642 644 646 514 531 535 620 622 621 623.0 682 670 665 664 663 662 661 660 659 562 Fibroblast growth factor receptor 1
TYR FGFR3 FGFR3_HUMAN 8UDTA P22607 457 756 806.0 MLT:61001,MLT:61002,WGF:61003 Allosteric,Allosteric,Type1.5_Front Inactive DFGin 5.4408 13.493 BLAplus -114.8, 158.79 55.69, 43.2 -82.19, -34.37 42.84, 89.08 -83.27, -4.41 in-out in 8.3828 Saltbr-out 5.2872 HRD-in -68.34, -46.54 75.89, -9.4 out-out-out SNCooo out-out ActLoopNT-out 7.9211 ActLoopCT-out TYR APEdihe_nnoai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 112.29 APE8-dihe-out -63.06, -32.23 APE8-rot-na 340.92 APE67-dihe-in -68.35, -26.42 -62.13, -28.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.1982 P572S,P573G None None XRAY 2.829 0.263 0.274 A 297.0 284.0 4 30 26 4 [[472, 750]] 1.0 8udt Homo sapiens TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 8UDTB P22607 457 754 806.0 WGF:62001 Type1.5_Front Inactive DFGin 5.2581 13.7103 BLAplus -108.64, 157.87 56.15, 40.62 -79.39, -35.54 45.72, 88.06 -80.67, 0.1 in-out in 8.4451 Saltbr-out 5.3977 HRD-in -67.98, -43.8 74.91, -8.8 out-out-out SNCooo out-out ActLoopNT-out 7.8672 ActLoopCT-out TYR APEdihe_nooai APEdist_aaao APE10-dihe-none 999.0, -64.67 APE9-dihe-out -68.82, -39.67 APE8-dihe-out -56.45, -17.85 APE8-rot-na 337.42 APE67-dihe-in -61.76, -27.35 -59.02, -40.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.6665 APE9-dist-out 10.854 P572S,P573G None None XRAY 2.829 0.263 0.274 B 297.0 283.0 3 30 27 3 [[472, 750]] 1.0 8udt Homo sapiens TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR3 FGFR3_HUMAN 8UDTC P22607 457 756 806.0 WGF:62001 Type1.5_Front Inactive DFGin 5.2583 13.8238 BLAplus -109.74, 157.08 55.91, 40.67 -78.94, -35.79 45.97, 87.77 -81.04, -4.46 in-out in 8.545 Saltbr-out 4.1026 HRD-in -68.09, -46.3 75.11, -4.3 out-out-out SNCooo out-out ActLoopNT-out 7.8702 ActLoopCT-out TYR APEdihe_nooai APEdist_aaao APE10-dihe-none 999.0, -150.08 APE9-dihe-out -67.3, -42.56 APE8-dihe-out -46.98, -31.66 APE8-rot-na 333.46 APE67-dihe-in -60.08, -29.46 -58.03, -43.82 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 18.4047 APE9-dist-out 11.049 P572S,P573G None None XRAY 2.829 0.263 0.274 C 297.0 284.0 4 30 26 4 [[472, 750]] 1.0 8udt Homo sapiens TYR_FGFR3_HUMAN TYR 8.4e-105 355.7 1.0 260.0 260.0 634 635 636 638 640 508 525 529 614 616 615 617.0 676 664 659 658 657 656 655 654 653 556 Fibroblast growth factor receptor 3
TYR FGFR4 FGFR4_HUMAN 7WCXA P22455 453 752 802.0 90F:801 Type1 Inactive DFGin 5.2632 13.1414 BLAplus -114.81, 160.0 54.39, 48.08 -89.68, -16.38 44.55, 83.39 -109.65, 26.27 in-in in 7.7923 Saltbr-in 2.5114 HRD-in -76.2, -43.73 72.01, -8.39 in-out-out SNCioo out-out ActLoopNT-out 8.6444 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -80.24, 137.24 APE9-dihe-in -109.54, 93.42 APE8-dihe-out -57.65, -19.77 APE8-rot-na 335.57 APE67-dihe-in -71.93, -5.42 -64.19, -25.82 APE12-dist-na 19.0736 APE11-dist-na 20.85 APE10-dist-na 16.8219 APE9-dist-out 11.9043 C477A,R664E None None XRAY 2.175 0.173 0.221 A 309.0 300.0 0 30 30 0 [[467, 745]] 1.0 7wcx Homo sapiens TYR_FGFR4_HUMAN TYR 7e-101 342.8 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 7WCWA P22455 453 752 802.0 90F:801 Type1 Inactive DFGin 5.8394 13.063 BLAplus -123.48, 161.59 54.95, 50.1 -96.76, -24.53 39.59, 83.16 -101.63, 31.89 in-in in 7.5817 Saltbr-in 3.4 HRD-in -77.43, -45.16 72.65, -7.54 in-out-out SNCioo out-out ActLoopNT-out 8.6329 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -81.49, 135.61 APE9-dihe-in -107.87, 94.77 APE8-dihe-out -59.45, -18.22 APE8-rot-na 336.81 APE67-dihe-in -74.15, -1.22 -67.3, -23.03 APE12-dist-na 19.4349 APE11-dist-na 20.9958 APE10-dist-na 16.9286 APE9-dist-out 11.8399 C477A,R664E None None XRAY 2.317 0.179 0.221 A 309.0 300.0 0 30 30 0 [[467, 745]] 1.0 7wcw Homo sapiens TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 6JPJA P22455 454 752 802.0 FGF:800 Type1 Inactive DFGin 5.301 12.6584 BLAplus -117.71, 161.57 53.08, 42.72 -89.02, -4.4 50.47, 87.12 -117.52, 24.43 in-in in 7.2473 Saltbr-in 2.3178 HRD-out -71.89, 98.16 -78.45, 15.53 in-out-out SNCioo out-out ActLoopNT-out 8.0019 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -85.03, 139.81 APE9-dihe-in -112.83, 87.62 APE8-dihe-out -50.76, -19.28 APE8-rot-na 332.54 APE67-dihe-in -80.03, 5.83 -68.35, -18.64 APE12-dist-na 19.2943 APE11-dist-na 21.0682 APE10-dist-na 17.1289 APE9-dist-out 12.054 C477A,R664E None None XRAY 2.638 0.198 0.243 A 311.0 299.0 0 30 30 0 [[467, 745]] 1.0 6jpj Homo sapiens TYR_FGFR4_HUMAN TYR 1.3e-100 341.9 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 7VJLA P22455 454 753 802.0 7IF:801 Type1 Inactive DFGin 5.3011 12.4196 BLAplus -114.78, 170.3 57.71, 40.42 -94.32, 21.48 55.77, 90.38 -107.29, 999.0 in-in in 7.4851 Saltbr-in 2.9035 HRD-out -79.19, -58.83 -98.34, 2.36 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 2.26 APE8-rot-na 31.94 APE67-dihe-in -59.38, -20.97 -56.11, -39.64 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.212 0.273 A 301.0 263.0 37 30 11 19 [[467, 745]] 1.0 7vjl Homo sapiens TYR_FGFR4_HUMAN TYR 1.1e-100 342.2 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 7VJLB P22455 453 753 802.0 7IF:801 Type1 Inactive DFGin 5.4049 13.2037 BLAplus -123.58, 175.88 60.77, 35.86 -95.6, 5.83 48.51, 81.65 -122.94, 999.0 in-in in 7.8757 Saltbr-in 2.6652 HRD-out -72.76, -57.66 -103.85, -18.8 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 6.57 APE8-rot-na 30.25 APE67-dihe-in -55.58, -34.43 -70.09, -36.28 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.212 0.273 B 301.0 266.0 35 30 11 19 [[467, 745]] 1.0 7vjl Homo sapiens TYR_FGFR4_HUMAN TYR 1.1e-100 342.2 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 6YI8A P22455 453 753 802.0 FGF:801 Type1 Inactive DFGin 5.0516 12.5848 BLAplus -114.37, 162.1 61.01, 37.7 -86.22, -22.44 57.75, 86.82 -88.83, -1.63 in-in in 7.21 Saltbr-in 2.807 HRD-in -68.35, -54.97 79.66, -18.38 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 137.99 APE9-dihe-in -91.08, 144.79 APE8-dihe-in -80.88, 56.75 APE8-rot-na 32.63 APE67-dihe-in -69.74, -13.54 -50.67, -37.69 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 19.1286 APE9-dist-out 9.5625 None None None XRAY 2.13 0.198 0.231 A 307.0 277.0 24 30 15 15 [[467, 745]] 1.0 6yi8 Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 6YI8B P22455 451 752 802.0 FGF:801 Type1 Inactive DFGin 5.5513 13.0744 BLAplus -114.83, 168.14 49.73, 54.77 -99.35, -32.03 46.0, 89.99 -71.98, 999.0 in-in in 7.3993 Saltbr-in 2.8136 HRD-in -67.69, -51.4 79.31, -36.01 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 133.49 APE8-dihe-in -88.73, 63.1 APE8-rot-na 25.93 APE67-dihe-in -70.74, -12.22 -53.82, -35.59 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.0812 None None None XRAY 2.13 0.198 0.231 B 307.0 270.0 32 30 12 18 [[467, 745]] 1.0 6yi8 Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.1 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 7WCTA P22455 453 752 802.0 90F:801 Type1 Inactive DFGin 5.4993 13.0077 BLAplus -115.75, 158.15 54.59, 44.67 -82.33, -22.35 42.51, 87.35 -106.03, 33.12 in-in in 7.4757 Saltbr-in 2.8808 HRD-in -76.31, -44.07 70.33, -3.05 in-out-out SNCioo out-out ActLoopNT-out 8.4968 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -84.18, 139.68 APE9-dihe-in -111.32, 93.14 APE8-dihe-out -55.09, -20.87 APE8-rot-na 333.3 APE67-dihe-in -74.74, -3.5 -65.15, -23.14 APE12-dist-na 19.4627 APE11-dist-na 21.0452 APE10-dist-na 17.0744 APE9-dist-out 11.7717 R664E None None XRAY 2.106 0.184 0.217 A 311.0 300.0 0 30 30 0 [[467, 745]] 1.0 7wct Homo sapiens TYR_FGFR4_HUMAN TYR 1.9e-100 341.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 5XFJA P22455 453 750 802.0 6LF:801 Type1 Inactive DFGin 5.0214 13.2508 None -115.6, 133.16 70.83, 138.96 -157.69, 175.22 19.16, 82.91 -161.9, 174.05 in-out in 8.3097 Saltbr-out 4.2744 HRD-out -142.96, 112.57 -85.34, -51.29 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -47.84 APE8-dihe-in -93.04, 75.41 APE8-rot-na 34.31 APE67-dihe-in -59.81, -17.88 -81.83, -32.18 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.229 V550M None None XRAY 3.25 0.284 0.336 A 311.0 266.0 32 30 13 17 [[467, 745]] 1.0 5xfj Homo sapiens TYR_FGFR4_HUMAN TYR 4.5e-101 343.4 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 5XFFA P22455 453 750 802.0 6LF:801 Type1 Inactive DFGin 7.2509 13.8003 None -91.81, 157.14 71.12, 141.83 -151.53, 140.75 303.34, 100.5 -174.03, 158.26 in-in in 7.9065 Saltbr-in 3.5618 HRD-out -144.83, 101.6 -75.14, -41.6 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -18.13 APE8-dihe-in -83.47, 67.75 APE8-rot-na 31.32 APE67-dihe-in -75.73, 1.3 -73.66, -27.62 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.5407 V550L None None XRAY 2.7 0.27 0.32 A 311.0 269.0 29 30 13 17 [[467, 745]] 1.0 5xff Homo sapiens TYR_FGFR4_HUMAN TYR 1.2e-100 342.0 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FGFR4 FGFR4_HUMAN 5JKGA P22455 453 750 802.0 6LF:801 Type1 Inactive DFGin 4.645 13.4149 None -80.35, 138.57 42.13, 154.03 -151.26, -44.79 29.5, 89.83 59.57, 154.84 in-in in 7.7877 Saltbr-in 2.7483 HRD-out -157.35, 80.6 -45.38, -51.27 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -51.98 APE8-dihe-in -77.75, 74.49 APE8-rot-na 28.85 APE67-dihe-in -78.7, 0.61 -72.33, -28.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 10.4055 None None None XRAY 2.352 0.237 0.277 A 311.0 266.0 32 30 13 17 [[467, 745]] 1.0 5jkg Homo sapiens TYR_FGFR4_HUMAN TYR 8.4e-101 342.6 1.0 261.0 261.0 629 630 631 633 635 503 520 524 609 611 610 612.0 671 659 654 653 652 651 650 649 648 551 Fibroblast growth factor receptor 4
TYR FLT3 FLT3_HUMAN 6JQRA P36888 571 951 993.0 C6F:1001 Type1 Inactive DFGout 15.3937 10.8847 None -119.73, 157.71 -104.23, 115.68 77.2, 999.0 255.94, 91.42 999.0, 999.0 in-in in 8.3262 Saltbr-in 2.8041 HRD-out -98.26, 117.82 -85.48, 11.47 in-none-in SNCini none-in ActLoopNT-none 999.0 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -131.05, 100.76 APE9-dihe-in -103.87, 123.04 APE8-dihe-in -78.74, 70.62 APE8-rot-na 34.5 APE67-dihe-in -69.1, -11.06 -54.04, -46.43 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 7.223 None None None XRAY 2.2 0.181 0.213 A 330.0 301.0 29 30 24 6 [[610, 945]] 1.0 6jqr Homo sapiens TYR_FLT3_HUMAN TYR 8.5e-103 349.1 1.0 259.0 259.0 828 829 830 832 834 644 661 665 808 810 809 811.0 870 858 853 852 851 850 849 848 847 692 Receptor-type tyrosine-protein kinase FLT3
TYR HCK HCK_HUMAN 3VS4A P08631 81 526 526.0 VSF:60603 Type1.5_Back Inactive DFGin 5.2959 12.6167 BLBplus -129.05, 156.5 78.18, 7.28 -55.31, 122.08 48.34, 94.72 91.65, -36.18 out-out out 13.5298 Saltbr-out 14.391 HRD-in -89.51, -57.9 84.08, -11.13 out-out-out SNCooo out-out ActLoopNT-out 6.8746 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 47.3 APE8-dihe-in -93.7, 67.91 APE8-rot-na 28.82 APE67-dihe-in -68.45, -16.47 -64.44, -22.55 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.6975 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.747 0.265 0.265 A 454.0 429.0 11 29 18 11 [[262, 513]] 1.0 3vs4 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR HCK HCK_HUMAN 3VS4B P08631 81 526 526.0 VSF:60603 Type1.5_Back Inactive DFGin 5.2845 12.6652 BLBplus -120.89, 167.83 61.49, 15.86 -62.02, 121.53 47.24, 95.4 75.03, 10.7 out-out out 13.7661 Saltbr-out 15.0419 HRD-in -94.45, -46.27 74.87, -7.2 out-out-out SNCooo out-out ActLoopNT-out 7.1349 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 48.23 APE8-dihe-in -84.31, 74.96 APE8-rot-na 34.0 APE67-dihe-in -71.24, -2.76 -88.69, -13.52 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.5953 Q523E,Q524E,Q525I PTR522 PTR522 XRAY 2.747 0.265 0.265 B 454.0 434.0 12 29 17 12 [[262, 513]] 1.0 3vs4 Homo sapiens TYR_HCK_HUMAN TYR 1.4e-95 325.6 1.0 260.0 260.0 398 399 400 402 404 290 305 309 378 380 379 381.0 439 427 422 421 420 419 418 417 416 334 Tyrosine-protein kinase HCK
TYR JAK2-1 JAK2_HUMAN 8B9EA O60674 536 809 1132.0 Q7F:1003 Type1 Pseudo DFGin 5.7694 13.2256 None -72.27, 175.04 -67.31, 162.54 -76.41, -26.42 340.6, 33.67 78.05, -163.23 out-na out 11.7256 Saltbr-na 999.0 HRD-in -83.9, -60.17 88.41, -6.41 na-out-out SNCaoo out-out ActLoopNT-out 8.9495 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -67.18, -39.02 APE9-dihe-out -59.74, -28.13 APE8-dihe-out -86.36, 6.28 APE8-rot-na 284.57 APE67-dihe-out -105.41, 26.85 -68.63, 134.78 APE12-dist-na 9.6132 APE11-dist-na 11.3156 APE10-dist-na 15.8543 APE9-dist-out 12.1058 W777A,F794H None None XRAY 1.5 0.17 0.194 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8b9e Homo sapiens TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8B9HA O60674 536 809 1132.0 Q7F:901 Type1 Pseudo DFGin 6.0102 13.3074 None -84.93, -177.89 -74.12, 157.3 -67.76, -31.57 343.4, 32.07 81.26, -168.8 out-na out 12.0967 Saltbr-na 999.0 HRD-in -82.25, -60.3 91.76, -5.32 na-out-out SNCaoo out-out ActLoopNT-out 9.1429 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.85, -39.85 APE9-dihe-out -62.27, -26.85 APE8-dihe-out -86.04, 1.76 APE8-rot-na 292.25 APE67-dihe-out -100.68, 23.58 -62.84, 136.16 APE12-dist-na 9.712 APE11-dist-na 11.4338 APE10-dist-na 15.9334 APE9-dist-out 12.4277 W659A,W777A,F794H None None XRAY 1.5 0.182 0.208 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 8b9h Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR KDR VGFR2_HUMAN 3VO3A P35968 812 1168 1356.0 0KF:2001 Type2 Inactive DFGout 16.4477 8.2146 None -125.16, 179.81 -141.05, 99.79 -70.03, -34.74 215.55, 55.41 59.77, -120.61 in-in in 7.3573 Saltbr-in 2.8979 HRD-in -84.45, -53.71 76.95, -3.4 in-out-in SNCioi out-in ActLoopNT-out 16.4768 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -112.91, 109.54 APE9-dihe-in -120.7, 147.5 APE8-dihe-in -78.09, 65.8 APE8-rot-na 32.33 APE67-dihe-in -67.73, -12.3 -53.4, -39.21 APE12-dist-na 17.0304 APE11-dist-na 14.0671 APE10-dist-na 11.3935 APE9-dist-in 7.9974 None None None XRAY 1.52 0.162 0.182 A 318.0 303.0 4 30 30 0 [[834, 1162]] 1.0 3vo3 Homo sapiens TYR_KDR_HUMAN TYR 4.2e-100 340.3 1.0 260.0 260.0 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028.0 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
TYR KDR VGFR2_HUMAN 1YWNA P35968 820 1171 1356.0 LIF:60301 Type1 Inactive None 999.0 999.0 None -128.91, 171.96 -143.62, 999.0 999.0, 999.0 999.0, 999.0 999.0, 999.0 in-in in 7.2102 Saltbr-in 2.725 HRD-in -77.88, -50.07 82.87, -17.6 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_iioai APEdist_aaao APE10-dihe-in -141.39, 161.44 APE9-dihe-in -104.18, 100.32 APE8-dihe-out -56.09, -24.71 APE8-rot-na 336.02 APE67-dihe-in -70.59, -14.0 -51.58, -32.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 11.2392 E990V PTR1054,PTR1059 PTR1054,PTR1059 XRAY 1.71 0.206 0.23 A 316.0 281.0 21 30 24 6 [[834, 1162]] 1.0 1ywn Homo sapiens TYR_KDR_HUMAN TYR 4.1e-100 340.3 1.0 260.0 260.0 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028.0 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
TYR LCK LCK_HUMAN 2ZM1A P06239 231 501 509.0 KSF:513 Type1 Active DFGin 6.4993 14.1929 BLAminus -132.48, -160.42 31.13, 88.01 -99.25, 22.14 293.45, 97.67 -69.47, -32.89 in-in in 8.5119 Saltbr-in 2.9335 HRD-in -100.89, -51.07 73.44, -7.06 in-in-in SNCiii in-in ActLoopNT-in 2.929 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -115.43, 148.33 APE9-dihe-in -138.82, 152.04 APE8-dihe-in -57.54, 117.05 APE8-rot-na 333.13 APE67-dihe-in -71.51, -24.6 -61.57, -39.74 APE12-dist-na 15.1006 APE11-dist-na 10.3495 APE10-dist-na 13.0138 APE9-dist-in 6.8223 None PTR394 PTR394 XRAY 2.1 0.172 0.232 A 285.0 271.0 0 29 29 0 [[245, 496]] 1.0 2zm1 Homo sapiens TYR_LCK_HUMAN TYR 1.5e-94 322.1 1.0 260.0 260.0 381 382 383 385 387 273 288 292 361 363 362 364.0 422 410 405 404 403 402 401 400 399 317 Tyrosine-protein kinase Lck
TYR MERTK MERTK_HUMAN 9BHIA Q12866 578 864 999.0 A1APF:60901 Type1.5_Front Inactive DFGin 6.9923 12.8049 BLAminus -138.66, -158.87 44.96, 74.5 -90.39, 18.73 305.52, 137.7 -55.48, -30.3 out-out out 13.6153 Saltbr-out 13.031 HRD-in -81.75, -51.8 68.35, 6.62 out-in-out SNCoio in-out ActLoopNT-in 2.8195 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaai APE10-dihe-out -100.15, 11.33 APE9-dihe-in -72.53, 150.77 APE8-dihe-in -64.75, 117.67 APE8-rot-na 25.92 APE67-dihe-in -73.91, -0.64 -53.67, -34.29 APE12-dist-na 7.154 APE11-dist-na 12.0556 APE10-dist-na 11.6569 APE9-dist-in 6.7096 None None None XRAY 2.07 0.211 0.23 A 323.0 278.0 9 30 28 2 [[587, 856]] 1.0 9bhi Homo sapiens TYR_MERTK_HUMAN TYR 1.6e-92 315.5 2.0 261.0 260.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MERTK MERTK_HUMAN 7AB1A Q12866 571 862 999.0 C6F:60901 Type1 Inactive DFGin 5.8722 13.5268 None -150.27, 178.21 48.78, 48.66 -107.87, 999.0 41.9, 85.18 999.0, 999.0 out-out out 12.8443 Saltbr-out 9.5657 HRD-in -84.92, -52.07 85.67, -41.55 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 62.29 APE8-rot-na 36.31 APE67-dihe-in -65.53, -14.5 -57.08, -42.11 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 K591R,K693R,K702R,K856R None None XRAY 1.93 0.237 0.298 A 298.0 267.0 25 30 10 20 [[587, 856]] 1.0 7ab1 Homo sapiens TYR_MERTK_HUMAN TYR 2.3e-92 314.9 2.0 260.0 259.0 740 741 742 744 746 619 637 641 720 722 721 723.0 782 770 765 764 763 762 761 760 759 672 Tyrosine-protein kinase Mer
TYR MET MET_HUMAN 3ZCLA P08581 1052 1345 1390.0 5TF:1 Type1 Inactive DFGin 5.3407 14.0328 BLBplus -130.37, -159.34 48.43, 53.41 -147.61, 165.56 74.15, 92.01 59.61, -131.84 out-out out 14.6359 Saltbr-out 12.7854 HRD-in -76.45, -51.81 82.5, -13.86 out-out-in SNCooi out-in ActLoopNT-out 10.7346 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -70.5, 109.91 APE9-dihe-in -127.18, 152.9 APE8-dihe-in -78.54, 68.73 APE8-rot-na 30.54 APE67-dihe-in -82.79, -0.65 -60.11, -28.04 APE12-dist-na 22.9366 APE11-dist-na 18.1313 APE10-dist-na 17.7713 APE9-dist-in 7.3575 None None None XRAY 1.4 0.194 0.211 A 306.0 291.0 3 32 32 0 [[1078, 1339]] 1.0 3zcl Homo sapiens TYR_MET_HUMAN TYR 6.7e-92 313.6 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR MET MET_HUMAN 4MXCA P08581 1052 1346 1390.0 DWF:1401 Type2 Inactive DFGout 14.4103 10.3366 BBAminus -151.35, -174.18 -156.99, 122.43 -67.95, -16.78 287.52, 70.23 58.23, -116.98 in-in in 8.9293 Saltbr-in 3.5152 HRD-in -73.25, -51.06 80.68, -17.87 in-out-in SNCioi out-in ActLoopNT-out 15.2867 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -88.68, 108.68 APE9-dihe-in -118.71, 133.81 APE8-dihe-in -79.71, 72.93 APE8-rot-na 28.81 APE67-dihe-in -75.71, -5.79 -60.94, -31.89 APE12-dist-na 999.0 APE11-dist-na 13.6281 APE10-dist-na 10.2732 APE9-dist-in 7.344 None None None XRAY 1.632 0.18 0.207 A 319.0 290.0 5 32 27 5 [[1078, 1339]] 1.0 4mxc Homo sapiens TYR_MET_HUMAN TYR 7.7e-92 313.7 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5H3QA P04629 484 796 796.0 7HF:1001 Type1 Inactive DFGout 12.7078 6.5827 BBAminus 172.54, 156.19 -157.42, 160.24 -99.39, 17.97 295.12, 97.4 79.34, 29.52 in-out in 9.4475 Saltbr-out 5.8508 HRD-in -81.9, -52.58 77.47, -12.71 out-out-in SNCooi out-in ActLoopNT-out 15.8006 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -128.94, 112.39 APE9-dihe-in -107.73, 133.13 APE8-dihe-in -79.15, 63.42 APE8-rot-na 34.45 APE67-dihe-in -63.33, -18.08 -61.61, -34.65 APE12-dist-na 13.7485 APE11-dist-na 15.1996 APE10-dist-na 10.6807 APE9-dist-in 7.568 None None None XRAY 2.1 0.19 0.215 A 324.0 303.0 10 30 30 0 [[510, 783]] 1.0 5h3q Homo sapiens TYR_NTRK1_HUMAN TYR 2.4e-100 341.1 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR NTRK1 NTRK1_HUMAN 5KMJA P04629 486 795 796.0 6UF:901 Type3 Inactive DFGout 12.074 7.6023 None 156.98, 152.76 -155.56, 161.93 -106.33, 28.22 308.11, 127.92 67.17, 26.59 in-in in 9.7145 Saltbr-in 2.7723 HRD-in -79.87, -55.53 78.72, -12.42 in-out-in SNCioi out-in ActLoopNT-out 16.1073 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -122.86, 120.05 APE9-dihe-in -107.69, 130.38 APE8-dihe-in -83.48, 63.94 APE8-rot-na 32.0 APE67-dihe-in -63.64, -21.11 -52.37, -37.83 APE12-dist-na 15.0163 APE11-dist-na 15.494 APE10-dist-na 11.0956 APE9-dist-in 7.6003 None None None XRAY 2.04 0.196 0.226 A 329.0 300.0 6 30 30 0 [[510, 783]] 1.0 5kmj Homo sapiens TYR_NTRK1_HUMAN TYR 2.5e-100 341.0 2.0 260.0 259.0 667 668 669 671 673 544 560 564 647 649 648 650.0 709 697 692 691 690 689 688 687 686 590 High affinity nerve growth factor receptor
TYR PTK2 FAK1_HUMAN 4EBWA Q05397 411 686 1052.0 0PF:700 Type1 Inactive DFGinter 10.5201 8.0228 None -156.77, 167.19 -119.55, 38.35 -154.8, 160.1 57.14, 97.67 -105.09, 155.15 in-in in 7.2322 Saltbr-in 3.0214 HRD-out -85.85, 108.83 -92.42, -13.42 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_niiai APEdist_aaao APE10-dihe-none 999.0, 105.2 APE9-dihe-in -103.42, 143.85 APE8-dihe-in -74.96, 72.04 APE8-rot-na 29.05 APE67-dihe-in -70.29, -24.24 -52.29, -39.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 17.857 APE9-dist-out 9.3907 None None None XRAY 2.65 0.186 0.273 A 304.0 259.0 17 29 14 15 [[422, 678]] 1.0 4ebw Homo sapiens TYR_PTK2_HUMAN TYR 4.7e-93 317.2 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR SYK KSYK_HUMAN 5LMBA P43405 364 634 635.0 6ZF:701 Type1 Active DFGin 6.4476 14.2826 BLAminus -131.02, -173.87 62.28, 69.39 -93.16, 19.0 290.08, 82.25 -59.68, -28.46 in-in in 7.6957 Saltbr-in 2.454 HRD-in -78.06, -53.9 76.38, 4.89 in-in-in SNCiii in-in ActLoopNT-in 2.9631 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -72.66, 104.96 APE9-dihe-in -108.73, 152.4 APE8-dihe-in -79.7, 70.25 APE8-rot-na 31.84 APE67-dihe-in -69.34, -16.13 -51.43, -34.69 APE12-dist-na 13.0735 APE11-dist-na 10.546 APE10-dist-na 11.4482 APE9-dist-in 6.9588 None PTR525 PTR525 XRAY 1.95 0.178 0.228 A 277.0 265.0 6 31 31 0 [[370, 628]] 1.0 5lmb Homo sapiens TYR_SYK_HUMAN TYR 4.6e-90 307.4 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 5LMBB P43405 364 630 635.0 6ZF:701 Type1 None DFGin 6.5417 14.2074 BLAminus -133.05, -174.7 62.98, 72.21 -97.02, 21.38 290.54, 88.36 -62.52, -32.46 in-in in 7.7365 Saltbr-in 2.5556 HRD-in -77.26, -52.74 74.6, 8.57 in-in-none SNCiin in-none ActLoopNT-in 2.872 ActLoopCT-none TYR APEdihe_nniai APEdist_aaai APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 129.43 APE8-dihe-in -80.7, 73.18 APE8-rot-na 30.16 APE67-dihe-in -64.42, -18.25 -49.18, -37.44 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-in 6.9476 None PTR525 PTR525 XRAY 1.95 0.178 0.228 B 277.0 262.0 5 31 26 5 [[370, 628]] 1.0 5lmb Homo sapiens TYR_SYK_HUMAN TYR 4.6e-90 307.4 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4YJOA P43405 363 632 635.0 4DF:701 Type1 Active DFGin 7.1511 15.4037 BLAminus -136.57, 178.57 59.58, 80.7 -95.16, 22.65 286.36, 75.19 -55.96, -31.16 in-in in 8.3198 Saltbr-in 3.0437 HRD-in -80.48, -52.4 72.29, 6.84 in-in-in SNCiii in-in ActLoopNT-in 2.9567 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -56.5, 127.44 APE9-dihe-in -144.08, 83.31 APE8-dihe-in -75.74, 70.97 APE8-rot-na 33.07 APE67-dihe-in -63.43, -16.56 -52.99, -37.5 APE12-dist-na 999.0 APE11-dist-na 10.63 APE10-dist-na 7.9003 APE9-dist-in 7.5071 None None None XRAY 1.6 0.186 0.23 A 281.0 267.0 3 31 28 3 [[370, 628]] 1.0 4yjo Homo sapiens TYR_SYK_HUMAN TYR 4.8e-90 307.3 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 5TT7A P43405 358 635 635.0 7KF:60901 Type1 Active DFGin 6.3107 14.3414 BLAminus -130.62, -177.29 62.11, 72.82 -94.96, 21.67 289.95, 80.8 -60.6, -26.94 in-in in 7.7094 Saltbr-in 2.8404 HRD-in -77.7, -52.28 69.96, 13.2 in-in-in SNCiii in-in ActLoopNT-in 2.8781 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -81.65, 88.09 APE9-dihe-in -107.14, 140.48 APE8-dihe-in -78.3, 78.38 APE8-rot-na 32.04 APE67-dihe-in -64.56, -15.37 -56.64, -35.35 APE12-dist-na 13.888 APE11-dist-na 10.557 APE10-dist-na 10.3425 APE9-dist-in 6.8486 None None None XRAY 1.77 0.208 0.234 A 289.0 270.0 8 31 31 0 [[370, 628]] 1.0 5tt7 Homo sapiens TYR_SYK_HUMAN TYR 5.4e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4FYOA P43405 363 635 635.0 0VF:60701 Type1 None DFGin 6.5272 14.6759 BLAminus -132.65, -177.95 62.23, 72.42 -93.99, 21.12 289.45, 90.18 -61.07, -25.58 in-in in 7.7502 Saltbr-in 2.757 HRD-in -74.26, -50.97 72.76, 4.05 in-in-none SNCiin in-none ActLoopNT-in 2.9524 ActLoopCT-none TYR APEdihe_niiai APEdist_aaai APE10-dihe-none 999.0, 140.05 APE9-dihe-in -108.11, 144.2 APE8-dihe-in -76.07, 73.27 APE8-rot-na 27.85 APE67-dihe-in -65.29, -14.44 -52.41, -38.79 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 11.9467 APE9-dist-in 7.3079 None None None XRAY 1.4 0.22 0.24 A 291.0 263.0 10 31 27 4 [[370, 628]] 1.0 4fyo Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
TYR SYK KSYK_HUMAN 4GFGA P43405 363 635 635.0 0XF:60701 Type1 Active DFGin 6.3816 14.7063 BLAminus -133.41, -165.6 61.44, 68.78 -94.44, 29.51 290.84, 74.86 -64.09, -30.1 in-in in 8.5511 Saltbr-in 3.4972 HRD-in -86.12, -47.8 68.36, 5.25 in-in-in SNCiii in-in ActLoopNT-in 2.8664 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -53.12, 138.6 APE9-dihe-in -110.15, 137.21 APE8-dihe-in -65.63, 68.92 APE8-rot-na 25.72 APE67-dihe-in -68.08, -17.47 -52.98, -35.53 APE12-dist-na 9.5817 APE11-dist-na 10.6292 APE10-dist-na 11.7062 APE9-dist-in 7.231 None None None XRAY 2.35 0.221 0.246 A 291.0 273.0 0 31 31 0 [[370, 628]] 1.0 4gfg Homo sapiens TYR_SYK_HUMAN TYR 5.5e-90 307.1 5.0 260.0 256.0 511 512 513 515 517 402 420 424 491 493 492 494.0 554 542 537 536 535 534 533 532 531 449 Tyrosine-protein kinase SYK
CMGC MAPK14 MK14_MOUSE 5R9OA P47811 5 352 360.0 54F:401 Allosteric Inactive DFGin 7.6735 17.2107 BLBminus -136.39, -176.43 54.27, 60.09 -56.75, 144.98 283.51, 68.16 -67.8, 120.41 in-in in 9.802 Saltbr-in 2.8748 HRD-in -68.65, -55.19 86.09, -8.85 in-out-out SNCioo out-out ActLoopNT-out 10.3121 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.85, 133.85 APE9-dihe-na -63.65, -21.53 APE8-dihe-out -61.93, -15.63 APE8-rot-out 53.56 APE67-dihe-in -63.52, -19.95 -117.35, -20.3 APE12-dist-out 21.9806 APE11-dist-out 24.1562 APE10-dist-out 18.3738 APE9-dist-out 11.8682 None None None XRAY 1.6 0.18 0.196 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5r9o Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
TKL RIPK3 RIPK3_MOUSE 9LVHA Q9QZL0 13 312 486.0 MYF:401 Type1 None DFGin 6.2503 14.2588 BLAminus -136.98, 168.96 62.75, 89.32 -105.42, 15.63 293.79, 91.31 -62.49, -27.0 in-in in 8.3761 Saltbr-in 2.8787 HRD-in -72.81, -50.94 74.54, 2.05 in-in-none SNCiin in-none ActLoopNT-in 2.7779 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -60.25, -26.93 999.0, -1.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.38 0.251 0.271 A 325.0 263.0 37 34 15 19 [[20, 290]] 1.0 9lvh Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3.0 265.0 263.0 160 161 162 164 166 51 61 65 140 142 141 143.0 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9LVHB Q9QZL0 13 312 486.0 MYF:401 Type1 None DFGin 6.1435 14.0576 BLAminus -139.36, 174.01 57.76, 83.37 -93.9, 23.89 297.93, 87.69 -58.87, -31.82 in-in in 8.5813 Saltbr-in 2.8174 HRD-in -67.48, -56.31 78.93, 2.25 in-in-none SNCiin in-none ActLoopNT-in 2.713 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.93 APE8-rot-in 302.42 APE67-dihe-in -61.51, -26.08 -64.96, -15.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.38 0.251 0.271 B 325.0 266.0 34 34 16 18 [[20, 290]] 1.0 9lvh Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3.0 265.0 263.0 160 161 162 164 166 51 61 65 140 142 141 143.0 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
OTHER CDC7 CDC7_YEAST 7PT78 P06243 10 475 507.0 ADP:1001,BEF:1003 ATPlike,Allosteric Inactive DFGin 7.05 14.8279 ABAminus -125.48, -62.19 -62.72, 136.55 -132.76, 24.05 270.26, 81.1 -56.4, -43.64 in-out in 8.9564 Saltbr-out 6.8378 HRD-out -95.15, 91.19 -59.72, -45.2 out-in-out SNCoio in-out ActLoopNT-in 2.4184 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiii APE10-dihe-na -63.65, 141.8 APE9-dihe-na 169.57, -141.23 APE8-dihe-in -138.07, 164.32 APE8-rot-in 301.9 APE67-dihe-out 82.72, -175.36 -64.25, 106.81 APE12-dist-in 8.8541 APE11-dist-in 11.0152 APE10-dist-in 5.0432 APE9-dist-in 4.6257 None None None EM 3.8 999.0 999.0 8 507.0 402.0 64 107 61 46 [[33, 469]] 1.0 7pt7 Saccharomyces cerevisiae OTHER_CDC7_YEAST CMGC 4e-17 121.0 1.0 158.0 260.0 181 182 183 185 187 76 90 94 160 162 161 163.0 301 288 283 282 281 280 279 278 277 121 Cell division control protein 7
CMGC GSK3B A0A125YY75_TOXGG 9HVXA A0A125YY75 46 384 394.0 A1IYF:60401 Type1 Inactive DFGin 6.8122 13.7389 BLAminus -151.79, -170.99 58.28, 71.83 -90.67, 23.31 282.96, 81.43 -68.24, -23.58 in-in in 7.973 Saltbr-in 2.6702 HRD-in -79.27, -44.62 69.75, 6.05 in-in-out SNCiio in-out ActLoopNT-in 2.9155 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.04, -39.68 APE9-dihe-na -85.38, 168.26 APE8-dihe-in -65.75, 139.05 APE8-rot-out 179.82 APE67-dihe-in -62.31, -27.06 -57.82, -44.69 APE12-dist-in 13.5047 APE11-dist-in 11.8681 APE10-dist-in 7.3712 APE9-dist-in 3.4994 None PTR211 PTR211 XRAY 2.1 0.203 0.25 A 350.0 323.0 16 27 27 0 [[47, 344]] 1.0 9hvx Toxoplasma gondii CMGC_GSK3B_TOXGG CMGC 6.4e-71 244.9 1.0 301.0 301.0 194 195 196 198 200 76 88 92 173 175 174 176.0 234 221 216 215 214 213 212 211 210 128 Putative cell-cycle-associated protein kinase GSK
CMGC GSK3B A0A125YY75_TOXGG 9HW6A A0A125YY75 46 384 394.0 A1IYF:60401 Type1 Inactive DFGin 6.5538 13.5143 BLAminus -159.29, -172.81 63.26, 75.9 -98.23, 18.12 289.64, 83.03 -60.9, -17.5 in-in in 8.2475 Saltbr-in 2.9128 HRD-in -74.22, -42.3 70.91, -2.75 in-in-out SNCiio in-out ActLoopNT-in 2.7786 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_niio APE10-dihe-na -107.29, 145.01 APE9-dihe-na -102.07, 19.34 APE8-dihe-in -80.82, 138.15 APE8-rot-out 53.99 APE67-dihe-in -80.29, -18.75 -104.8, -54.34 APE12-dist-none 999.0 APE11-dist-in 10.1113 APE10-dist-in 7.183 APE9-dist-out 8.8047 None PTR211,SEP257 PTR211,SEP257 XRAY 2.9 0.207 0.26 A 373.0 332.0 7 27 24 3 [[47, 344]] 1.0 9hw6 Toxoplasma gondii CMGC_GSK3B_TOXGG CMGC 8e-71 244.6 1.0 301.0 301.0 194 195 196 198 200 76 88 92 173 175 174 176.0 234 221 216 215 214 213 212 211 210 128 Putative cell-cycle-associated protein kinase GSK
CMGC GSK3B A0A125YY75_TOXGG 9HW6B A0A125YY75 46 384 394.0 A1IYF:60402 Type1 Inactive DFGin 6.9687 13.759 BLAminus -158.71, -175.52 61.04, 75.48 -97.8, 20.68 289.3, 83.48 -61.51, -18.44 in-in in 8.3397 Saltbr-in 2.533 HRD-in -73.25, -38.58 70.21, -4.6 in-in-out SNCiio in-out ActLoopNT-in 2.9566 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnio APE10-dihe-na 999.0, 137.93 APE9-dihe-na -128.88, -94.97 APE8-dihe-out 8.76, 102.73 APE8-rot-out 52.93 APE67-dihe-in -72.89, -15.66 -99.47, -15.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.6732 APE9-dist-out 7.8742 None PTR211 PTR211 XRAY 2.9 0.207 0.26 B 373.0 332.0 7 27 21 6 [[47, 344]] 1.0 9hw6 Toxoplasma gondii CMGC_GSK3B_TOXGG CMGC 8e-71 244.6 1.0 301.0 301.0 194 195 196 198 200 76 88 92 173 175 174 176.0 234 221 216 215 214 213 212 211 210 128 Putative cell-cycle-associated protein kinase GSK
CMGC GSK3B A0A125YY75_TOXGG 9HW6D A0A125YY75 46 384 394.0 A1IYF:60402 Type1 Inactive DFGin 6.7524 13.5451 BLAminus -157.98, -176.25 63.15, 72.4 -94.88, 18.71 288.21, 86.06 -60.77, -17.66 in-in in 8.448 Saltbr-in 3.0006 HRD-in -74.85, -41.94 71.3, -1.92 in-in-out SNCiio in-out ActLoopNT-in 2.8531 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnio APE10-dihe-na 999.0, -28.71 APE9-dihe-na 70.23, 60.42 APE8-dihe-out -136.17, -56.82 APE8-rot-out 132.32 APE67-dihe-out -77.45, -28.23 69.46, -39.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.0768 APE9-dist-out 8.5822 None PTR211,SEP257 PTR211,SEP257 XRAY 2.9 0.207 0.26 D 373.0 327.0 12 27 18 9 [[47, 344]] 1.0 9hw6 Toxoplasma gondii CMGC_GSK3B_TOXGG CMGC 8e-71 244.6 1.0 301.0 301.0 194 195 196 198 200 76 88 92 173 175 174 176.0 234 221 216 215 214 213 212 211 210 128 Putative cell-cycle-associated protein kinase GSK
CMGC GSK3B A0A125YY75_TOXGG 9HW6F A0A125YY75 46 384 394.0 A1IYF:60401 Type1 Inactive DFGin 6.9801 13.8202 BLAminus -156.62, -174.56 59.51, 71.39 -97.24, 16.48 288.27, 84.06 -60.16, -18.79 in-in in 8.206 Saltbr-in 2.7353 HRD-in -76.38, -41.74 71.66, -4.7 in-in-out SNCiio in-out ActLoopNT-in 2.744 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_niio APE10-dihe-na -146.52, 154.45 APE9-dihe-na -92.11, 49.24 APE8-dihe-in -83.14, 134.37 APE8-rot-out 54.49 APE67-dihe-in -77.45, -15.85 -109.34, -69.31 APE12-dist-none 999.0 APE11-dist-in 9.9364 APE10-dist-in 6.6737 APE9-dist-out 9.0418 None PTR211 PTR211 XRAY 2.9 0.207 0.26 F 373.0 325.0 14 27 21 6 [[47, 344]] 1.0 9hw6 Toxoplasma gondii CMGC_GSK3B_TOXGG CMGC 8e-71 244.6 1.0 301.0 301.0 194 195 196 198 200 76 88 92 173 175 174 176.0 234 221 216 215 214 213 212 211 210 128 Putative cell-cycle-associated protein kinase GSK

Ligand: F

Total number of chains: 13
Active chains: 1
Total number of genes: 6
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 8 61.5% 9RETA
DFGin ABAminus 2 15.4% 7PIEA
DFGout BBAminus 2 15.4% 5SYSA
DFGin BLBminus 1 7.7% 5R9OA

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC PRKACA KAPCA_CRIGR 7PIEA P25321 1 351 351.0 7QF:60401 Type1 Inactive DFGin 6.4369 14.7079 ABAminus -120.2, -32.0 -97.5, 116.46 -117.79, 21.67 284.38, 87.37 -67.96, -24.99 in-in in 9.0175 Saltbr-in 2.947 HRD-in -90.08, -55.75 70.92, 8.29 in-in-in SNCiii in-in ActLoopNT-in 2.9298 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.9, 155.75 APE9-dihe-na 129.48, -166.45 APE8-dihe-in -116.19, 135.64 APE8-rot-in 298.32 APE67-dihe-in -59.08, -26.0 -47.12, -51.73 APE12-dist-in 8.298 APE11-dist-in 11.4827 APE10-dist-in 5.9206 APE9-dist-in 3.8942 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.427 0.137 0.158 A 353.0 350.0 0 25 25 0 [[44, 298]] 1.0 7pie Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 9RETA P25321 13 351 351.0 A1JEF:60404 Allosteric Active DFGin 6.5025 14.9192 BLAminus -121.64, 161.02 79.66, 89.44 -97.28, 25.84 271.42, 57.67 -59.32, -29.98 in-in in 9.0584 Saltbr-in 2.6884 HRD-in -91.57, -50.28 65.7, 14.34 in-in-in SNCiii in-in ActLoopNT-in 2.9609 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.82, 155.57 APE9-dihe-na 119.38, 155.92 APE8-dihe-in -73.83, 138.5 APE8-rot-in 315.72 APE67-dihe-in -57.32, -25.4 -54.39, -42.36 APE12-dist-in 8.1859 APE11-dist-in 11.4021 APE10-dist-in 5.9522 APE9-dist-in 4.2407 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.75 0.193 0.227 A 353.0 339.0 0 25 25 0 [[44, 298]] 1.0 9ret Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
TYR SRC SRC_CHICK 5SYSA P00523 258 533 533.0 72F:600 Type2 Inactive DFGout 13.3536 9.8008 BBAminus -126.48, -173.83 -168.38, 115.62 -104.78, -47.96 311.28, 146.33 163.56, 999.0 in-in in 8.5789 Saltbr-in 3.0301 HRD-in -86.37, -44.08 72.1, 11.73 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -16.31 APE8-rot-na 5.39 APE67-dihe-in -61.6, -39.03 -88.61, -20.33 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V281C None None XRAY 2.8 0.288 0.334 A 286.0 258.0 18 29 11 18 [[267, 518]] 1.0 5sys Gallus gallus TYR_SRC_CHICK TYR 4.2e-93 317.3 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 5SYSB P00523 258 533 533.0 72F:600 Type2 Inactive DFGout 13.4129 10.163 BBAminus -126.31, -175.1 -166.31, 115.77 -103.34, -47.57 306.63, 130.98 67.96, 999.0 in-in in 8.3206 Saltbr-in 3.0439 HRD-in -86.54, -44.23 72.2, 11.45 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaan APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -18.84 APE8-rot-na 6.43 APE67-dihe-in -61.0, -39.73 -89.58, -19.88 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-none 999.0 V281C None None XRAY 2.8 0.288 0.334 B 286.0 258.0 18 29 11 18 [[267, 518]] 1.0 5sys Gallus gallus TYR_SRC_CHICK TYR 4.2e-93 317.3 1.0 260.0 260.0 403 404 405 407 409 295 310 314 383 385 384 386.0 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
CMGC MAPK14 MK14_MOUSE 5R9OA P47811 5 352 360.0 54F:401 Allosteric Inactive DFGin 7.6735 17.2107 BLBminus -136.39, -176.43 54.27, 60.09 -56.75, 144.98 283.51, 68.16 -67.8, 120.41 in-in in 9.802 Saltbr-in 2.8748 HRD-in -68.65, -55.19 86.09, -8.85 in-out-out SNCioo out-out ActLoopNT-out 10.3121 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -136.85, 133.85 APE9-dihe-na -63.65, -21.53 APE8-dihe-out -61.93, -15.63 APE8-rot-out 53.56 APE67-dihe-in -63.52, -19.95 -117.35, -20.3 APE12-dist-out 21.9806 APE11-dist-out 24.1562 APE10-dist-out 18.3738 APE9-dist-out 11.8682 None None None XRAY 1.6 0.18 0.196 A 360.0 348.0 0 25 25 0 [[24, 308]] 1.0 5r9o Mus musculus CMGC_MAPK14_MOUSE CMGC 1.9e-85 292.7 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
TKL RIPK3 RIPK3_MOUSE 9LVHA Q9QZL0 13 312 486.0 MYF:401 Type1 None DFGin 6.2503 14.2588 BLAminus -136.98, 168.96 62.75, 89.32 -105.42, 15.63 293.79, 91.31 -62.49, -27.0 in-in in 8.3761 Saltbr-in 2.8787 HRD-in -72.81, -50.94 74.54, 2.05 in-in-none SNCiin in-none ActLoopNT-in 2.7779 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -60.25, -26.93 999.0, -1.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.38 0.251 0.271 A 325.0 263.0 37 34 15 19 [[20, 290]] 1.0 9lvh Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3.0 265.0 263.0 160 161 162 164 166 51 61 65 140 142 141 143.0 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
TKL RIPK3 RIPK3_MOUSE 9LVHB Q9QZL0 13 312 486.0 MYF:401 Type1 None DFGin 6.1435 14.0576 BLAminus -139.36, 174.01 57.76, 83.37 -93.9, 23.89 297.93, 87.69 -58.87, -31.82 in-in in 8.5813 Saltbr-in 2.8174 HRD-in -67.48, -56.31 78.93, 2.25 in-in-none SNCiin in-none ActLoopNT-in 2.713 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.93 APE8-rot-in 302.42 APE67-dihe-in -61.51, -26.08 -64.96, -15.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.38 0.251 0.271 B 325.0 266.0 34 34 16 18 [[20, 290]] 1.0 9lvh Mus musculus TKL_RIPK3_MOUSE TKL 5e-60 209.3 3.0 265.0 263.0 160 161 162 164 166 51 61 65 140 142 141 143.0 208 194 189 188 187 186 185 184 183 96 Receptor-interacting serine/threonine-protein kinase 3
OTHER CDC7 CDC7_YEAST 7PT78 P06243 10 475 507.0 ADP:1001,BEF:1003 ATPlike,Allosteric Inactive DFGin 7.05 14.8279 ABAminus -125.48, -62.19 -62.72, 136.55 -132.76, 24.05 270.26, 81.1 -56.4, -43.64 in-out in 8.9564 Saltbr-out 6.8378 HRD-out -95.15, 91.19 -59.72, -45.2 out-in-out SNCoio in-out ActLoopNT-in 2.4184 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iiii APE10-dihe-na -63.65, 141.8 APE9-dihe-na 169.57, -141.23 APE8-dihe-in -138.07, 164.32 APE8-rot-in 301.9 APE67-dihe-out 82.72, -175.36 -64.25, 106.81 APE12-dist-in 8.8541 APE11-dist-in 11.0152 APE10-dist-in 5.0432 APE9-dist-in 4.6257 None None None EM 3.8 999.0 999.0 8 507.0 402.0 64 107 61 46 [[33, 469]] 1.0 7pt7 Saccharomyces cerevisiae OTHER_CDC7_YEAST CMGC 4e-17 121.0 1.0 158.0 260.0 181 182 183 185 187 76 90 94 160 162 161 163.0 301 288 283 282 281 280 279 278 277 121 Cell division control protein 7
CMGC GSK3B A0A125YY75_TOXGG 9HVXA A0A125YY75 46 384 394.0 A1IYF:60401 Type1 Inactive DFGin 6.8122 13.7389 BLAminus -151.79, -170.99 58.28, 71.83 -90.67, 23.31 282.96, 81.43 -68.24, -23.58 in-in in 7.973 Saltbr-in 2.6702 HRD-in -79.27, -44.62 69.75, 6.05 in-in-out SNCiio in-out ActLoopNT-in 2.9155 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.04, -39.68 APE9-dihe-na -85.38, 168.26 APE8-dihe-in -65.75, 139.05 APE8-rot-out 179.82 APE67-dihe-in -62.31, -27.06 -57.82, -44.69 APE12-dist-in 13.5047 APE11-dist-in 11.8681 APE10-dist-in 7.3712 APE9-dist-in 3.4994 None PTR211 PTR211 XRAY 2.1 0.203 0.25 A 350.0 323.0 16 27 27 0 [[47, 344]] 1.0 9hvx Toxoplasma gondii CMGC_GSK3B_TOXGG CMGC 6.4e-71 244.9 1.0 301.0 301.0 194 195 196 198 200 76 88 92 173 175 174 176.0 234 221 216 215 214 213 212 211 210 128 Putative cell-cycle-associated protein kinase GSK
CMGC GSK3B A0A125YY75_TOXGG 9HW6A A0A125YY75 46 384 394.0 A1IYF:60401 Type1 Inactive DFGin 6.5538 13.5143 BLAminus -159.29, -172.81 63.26, 75.9 -98.23, 18.12 289.64, 83.03 -60.9, -17.5 in-in in 8.2475 Saltbr-in 2.9128 HRD-in -74.22, -42.3 70.91, -2.75 in-in-out SNCiio in-out ActLoopNT-in 2.7786 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_niio APE10-dihe-na -107.29, 145.01 APE9-dihe-na -102.07, 19.34 APE8-dihe-in -80.82, 138.15 APE8-rot-out 53.99 APE67-dihe-in -80.29, -18.75 -104.8, -54.34 APE12-dist-none 999.0 APE11-dist-in 10.1113 APE10-dist-in 7.183 APE9-dist-out 8.8047 None PTR211,SEP257 PTR211,SEP257 XRAY 2.9 0.207 0.26 A 373.0 332.0 7 27 24 3 [[47, 344]] 1.0 9hw6 Toxoplasma gondii CMGC_GSK3B_TOXGG CMGC 8e-71 244.6 1.0 301.0 301.0 194 195 196 198 200 76 88 92 173 175 174 176.0 234 221 216 215 214 213 212 211 210 128 Putative cell-cycle-associated protein kinase GSK
CMGC GSK3B A0A125YY75_TOXGG 9HW6B A0A125YY75 46 384 394.0 A1IYF:60402 Type1 Inactive DFGin 6.9687 13.759 BLAminus -158.71, -175.52 61.04, 75.48 -97.8, 20.68 289.3, 83.48 -61.51, -18.44 in-in in 8.3397 Saltbr-in 2.533 HRD-in -73.25, -38.58 70.21, -4.6 in-in-out SNCiio in-out ActLoopNT-in 2.9566 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnio APE10-dihe-na 999.0, 137.93 APE9-dihe-na -128.88, -94.97 APE8-dihe-out 8.76, 102.73 APE8-rot-out 52.93 APE67-dihe-in -72.89, -15.66 -99.47, -15.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 6.6732 APE9-dist-out 7.8742 None PTR211 PTR211 XRAY 2.9 0.207 0.26 B 373.0 332.0 7 27 21 6 [[47, 344]] 1.0 9hw6 Toxoplasma gondii CMGC_GSK3B_TOXGG CMGC 8e-71 244.6 1.0 301.0 301.0 194 195 196 198 200 76 88 92 173 175 174 176.0 234 221 216 215 214 213 212 211 210 128 Putative cell-cycle-associated protein kinase GSK
CMGC GSK3B A0A125YY75_TOXGG 9HW6D A0A125YY75 46 384 394.0 A1IYF:60402 Type1 Inactive DFGin 6.7524 13.5451 BLAminus -157.98, -176.25 63.15, 72.4 -94.88, 18.71 288.21, 86.06 -60.77, -17.66 in-in in 8.448 Saltbr-in 3.0006 HRD-in -74.85, -41.94 71.3, -1.92 in-in-out SNCiio in-out ActLoopNT-in 2.8531 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnio APE10-dihe-na 999.0, -28.71 APE9-dihe-na 70.23, 60.42 APE8-dihe-out -136.17, -56.82 APE8-rot-out 132.32 APE67-dihe-out -77.45, -28.23 69.46, -39.41 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-in 7.0768 APE9-dist-out 8.5822 None PTR211,SEP257 PTR211,SEP257 XRAY 2.9 0.207 0.26 D 373.0 327.0 12 27 18 9 [[47, 344]] 1.0 9hw6 Toxoplasma gondii CMGC_GSK3B_TOXGG CMGC 8e-71 244.6 1.0 301.0 301.0 194 195 196 198 200 76 88 92 173 175 174 176.0 234 221 216 215 214 213 212 211 210 128 Putative cell-cycle-associated protein kinase GSK
CMGC GSK3B A0A125YY75_TOXGG 9HW6F A0A125YY75 46 384 394.0 A1IYF:60401 Type1 Inactive DFGin 6.9801 13.8202 BLAminus -156.62, -174.56 59.51, 71.39 -97.24, 16.48 288.27, 84.06 -60.16, -18.79 in-in in 8.206 Saltbr-in 2.7353 HRD-in -76.38, -41.74 71.66, -4.7 in-in-out SNCiio in-out ActLoopNT-in 2.744 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_niio APE10-dihe-na -146.52, 154.45 APE9-dihe-na -92.11, 49.24 APE8-dihe-in -83.14, 134.37 APE8-rot-out 54.49 APE67-dihe-in -77.45, -15.85 -109.34, -69.31 APE12-dist-none 999.0 APE11-dist-in 9.9364 APE10-dist-in 6.6737 APE9-dist-out 9.0418 None PTR211 PTR211 XRAY 2.9 0.207 0.26 F 373.0 325.0 14 27 21 6 [[47, 344]] 1.0 9hw6 Toxoplasma gondii CMGC_GSK3B_TOXGG CMGC 8e-71 244.6 1.0 301.0 301.0 194 195 196 198 200 76 88 92 173 175 174 176.0 234 221 216 215 214 213 212 211 210 128 Putative cell-cycle-associated protein kinase GSK