TGFBR1 (TGF-beta receptor type-1)

Group: TKL
Uniprot: TGFR1_HUMAN
Domain boundary: 205 - 494


Total number of chains: 58
Spatial Dihedral Chains Representative
DFGin BLAminus 58 AF-P36897-K1A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
5E8UA 2.03 Active DFGin BLAminus in-in in-in No_ligand No_ligand 200 - 502 T204D,I211V,Y249F,S280T,Y282F,S287N,A350C,L352F None 0
4X2NA 1.8 Active DFGin BLAminus in-in in-in No_ligand No_ligand 200 - 501 None None 0
5E8SA 1.45 Active DFGin BLAminus in-in in-in No_ligand No_ligand 200 - 498 None None 0
AF-P36897-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 197 - 502 None None 0
5E8TA 1.7 Active DFGin BLAminus in-in in-in No_ligand No_ligand 200 - 499 T204D None 0
1B6CB 2.6 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 175 - 500 None None 0
1B6CD 2.6 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 175 - 500 None None 0
1B6CF 2.6 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 175 - 500 None None 0
1B6CH 2.6 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 175 - 500 None None 0
1IASA 2.9 Active DFGin BLAminus in-in in-in No_ligand No_ligand 171 - 500 None None 0
1IASB 2.9 Active DFGin BLAminus in-in in-in No_ligand No_ligand 171 - 501 None None 3
1IASC 2.9 Active DFGin BLAminus in-in in-in No_ligand No_ligand 171 - 500 None None 0
1IASD 2.9 Active DFGin BLAminus in-in in-in No_ligand No_ligand 171 - 500 None None 0
1IASE 2.9 Active DFGin BLAminus in-in in-in No_ligand No_ligand 171 - 500 None None 0
5E8XA 1.45 Active DFGin BLAminus in-in in-in STU Type1 200 - 503 T204D,I211V,Y249F,S280T,Y282F,S287N,A350C,L352F None 0
5E90A 2.05 Active DFGin BLAminus in-in in-in 5L4 Type1 200 - 499 T204D,I211V,Y249F,S280T,Y282F,S287N,A350C,L352F None 0
5USQA 2.55 Active DFGin BLAminus in-in in-in 8LY Type1 200 - 498 None None 0
1RW8A 2.4 Active DFGin BLAminus in-in in-in 580 Type1 200 - 500 None None 0
5FRIA 2.0 Active DFGin BLAminus in-in in-in ZUQ Type1 200 - 498 None None 0
1VJYA 2.0 Active DFGin BLAminus in-in in-in 460 Type1 201 - 503 None None 4
3GXLA 1.8 Active DFGin BLAminus in-in in-in QIG Type1 201 - 498 None None 5
3HMMA 1.7 Active DFGin BLAminus in-in in-in 855 Type1 201 - 498 None None 5
9F6XA 2.68 Active DFGin BLAminus in-in in-in A1IAZ Type1 200 - 500 None None 0
4X0MA 1.68 Active DFGin BLAminus in-in in-in 3WA Type1 200 - 501 None None 0
4X2FA 1.49 Active DFGin BLAminus in-in in-in 3WJ Type1 200 - 501 None None 0
4X2GA 1.51 Active DFGin BLAminus in-in in-in 3WK Type1 200 - 501 None None 0
9J9DA 1.337 Active DFGin BLAminus in-in in-in A1L30 Type1 202 - 502 None None 2
2WOTA 1.85 Active DFGin BLAminus in-in in-in ZZG Type1 200 - 500 None None 0
2WOUA 2.3 Active DFGin BLAminus in-in in-in ZZF Type1 200 - 496 None None 0
8YHLA 1.47 Active DFGin BLAminus in-in in-in A1D6I Type1 200 - 501 None None 0
5E8WA 1.86 Active DFGin BLAminus in-in in-in STU Type1 200 - 501 T204D None 0
5E8ZA 1.51 Active DFGin BLAminus in-in in-in 5L4 Type1 200 - 499 T204D None 0
5QIKA 1.58 Active DFGin BLAminus in-in in-in J2M Type1 200 - 499 T204D None 0
5QILA 1.98 Active DFGin BLAminus in-in in-in J2V Type1 200 - 499 T204D None 0
5QTZA 1.83 Active DFGin BLAminus in-in in-in QMY Type1 200 - 499 T204D None 0
5QU0A 1.67 Active DFGin BLAminus in-in in-in QMV Type1 200 - 502 T204D None 0
3TZMA 1.7 Active DFGin BLAminus in-in in-in 085 Type1 200 - 496 None None 2
1PY5A 2.3 Active DFGin BLAminus in-in in-in PY1 Type1 200 - 500 None None 0
2X7OA 3.7 Active DFGin BLAminus in-in in-in ZOP Type1 171 - 500 None None 0
2X7OB 3.7 Inactive DFGin BLAminus in-out in-in ZOP Type1 171 - 500 None None 0
3FAAA 3.35 Active DFGin BLAminus in-in in-in 55F Type1 171 - 500 None None 2
3FAAB 3.35 Active DFGin BLAminus in-in in-in 55F Type1 171 - 501 None None 3
3FAAC 3.35 Active DFGin BLAminus in-in in-in 55F Type1 171 - 500 None None 0
3FAAD 3.35 Active DFGin BLAminus in-in in-in 55F Type1 171 - 500 None None 0
3FAAE 3.35 Active DFGin BLAminus in-in in-in 55F Type1 171 - 500 None None 0
8YHFA 1.4 Active DFGin BLAminus in-in in-in A1D6I Type1 201 - 498 None None 0
4X2JA 1.69 Active DFGin BLAminus in-in in-in 3WN Type1.5_Back 200 - 501 None None 0
4X2KA 1.69 Active DFGin BLAminus in-in in-in 3WO Type1.5_Back 200 - 501 None None 0
5QIMA 1.75 Active DFGin BLAminus in-in in-in J2Y Type1.5_Back 200 - 501 None None 0
6B8YA 1.65 Active DFGin BLAminus in-in in-in D0A Type1.5_Back 200 - 502 T204D None 0
2X7OC 3.7 Active DFGin BLAminus in-in in-in ZOP Type1.5_Back 171 - 500 None None 0
2X7OD 3.7 Active DFGin BLAminus in-in in-in ZOP Type1.5_Back 171 - 500 None None 0
2X7OE 3.7 Active DFGin BLAminus in-in in-in ZOP Type1.5_Back 171 - 500 None None 0
3KCFA 2.8 Active DFGin BLAminus in-in in-in JZO Type1.5_Back 171 - 500 None None 2
3KCFB 2.8 Active DFGin BLAminus in-in in-in JZO Type1.5_Back 171 - 501 None None 3
3KCFC 2.8 Active DFGin BLAminus in-in in-in JZO Type1.5_Back 171 - 500 None None 0
3KCFD 2.8 Active DFGin BLAminus in-in in-in JZO Type1.5_Back 171 - 500 None None 0
3KCFE 2.8 Active DFGin BLAminus in-in in-in JZO Type1.5_Back 171 - 500 None None 0

TGFBR1 (TGF-beta receptor type-1)

Group: TKL
Total number of chains: 58
Spatial Dihedral Chains Representative
DFGin BLAminus 58 AF-P36897-K1A
Representatives from each cluster
Pymol session(ver 2.3) Pymol script
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism UniprotID PDB Resolution Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Mutation Phosphorylation Unresolved residues in A-loop
Homo sapiens TGFR1_HUMAN 5E8UA 2.03 Active DFGin BLAminus in-in in-in No_ligand No_ligand 200 - 502 T204D,I211V,Y249F,S280T,Y282F,S287N,A350C,L352F None 0
Homo sapiens TGFR1_HUMAN 4X2NA 1.8 Active DFGin BLAminus in-in in-in No_ligand No_ligand 200 - 501 None None 0
Homo sapiens TGFR1_HUMAN 5E8SA 1.45 Active DFGin BLAminus in-in in-in No_ligand No_ligand 200 - 498 None None 0
Homo sapiens TGFR1_HUMAN AF-P36897-K1A -1.0 Active DFGin BLAminus in-in in-in No_ligand No_ligand 197 - 502 None None 0
Homo sapiens TGFR1_HUMAN 5E8TA 1.7 Active DFGin BLAminus in-in in-in No_ligand No_ligand 200 - 499 T204D None 0
Homo sapiens TGFR1_HUMAN 1B6CB 2.6 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 175 - 500 None None 0
Homo sapiens TGFR1_HUMAN 1B6CD 2.6 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 175 - 500 None None 0
Homo sapiens TGFR1_HUMAN 1B6CF 2.6 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 175 - 500 None None 0
Homo sapiens TGFR1_HUMAN 1B6CH 2.6 Inactive DFGin BLAminus in-out in-in No_ligand No_ligand 175 - 500 None None 0
Homo sapiens TGFR1_HUMAN 1IASA 2.9 Active DFGin BLAminus in-in in-in No_ligand No_ligand 171 - 500 None None 0
Homo sapiens TGFR1_HUMAN 1IASB 2.9 Active DFGin BLAminus in-in in-in No_ligand No_ligand 171 - 501 None None 3
Homo sapiens TGFR1_HUMAN 1IASC 2.9 Active DFGin BLAminus in-in in-in No_ligand No_ligand 171 - 500 None None 0
Homo sapiens TGFR1_HUMAN 1IASD 2.9 Active DFGin BLAminus in-in in-in No_ligand No_ligand 171 - 500 None None 0
Homo sapiens TGFR1_HUMAN 1IASE 2.9 Active DFGin BLAminus in-in in-in No_ligand No_ligand 171 - 500 None None 0
Homo sapiens TGFR1_HUMAN 5E8XA 1.45 Active DFGin BLAminus in-in in-in STU Type1 200 - 503 T204D,I211V,Y249F,S280T,Y282F,S287N,A350C,L352F None 0
Homo sapiens TGFR1_HUMAN 5E90A 2.05 Active DFGin BLAminus in-in in-in 5L4 Type1 200 - 499 T204D,I211V,Y249F,S280T,Y282F,S287N,A350C,L352F None 0
Homo sapiens TGFR1_HUMAN 5USQA 2.55 Active DFGin BLAminus in-in in-in 8LY Type1 200 - 498 None None 0
Homo sapiens TGFR1_HUMAN 1RW8A 2.4 Active DFGin BLAminus in-in in-in 580 Type1 200 - 500 None None 0
Homo sapiens TGFR1_HUMAN 5FRIA 2.0 Active DFGin BLAminus in-in in-in ZUQ Type1 200 - 498 None None 0
Homo sapiens TGFR1_HUMAN 1VJYA 2.0 Active DFGin BLAminus in-in in-in 460 Type1 201 - 503 None None 4
Homo sapiens TGFR1_HUMAN 3GXLA 1.8 Active DFGin BLAminus in-in in-in QIG Type1 201 - 498 None None 5
Homo sapiens TGFR1_HUMAN 3HMMA 1.7 Active DFGin BLAminus in-in in-in 855 Type1 201 - 498 None None 5
Homo sapiens TGFR1_HUMAN 9F6XA 2.68 Active DFGin BLAminus in-in in-in A1IAZ Type1 200 - 500 None None 0
Homo sapiens TGFR1_HUMAN 4X0MA 1.68 Active DFGin BLAminus in-in in-in 3WA Type1 200 - 501 None None 0
Homo sapiens TGFR1_HUMAN 4X2FA 1.49 Active DFGin BLAminus in-in in-in 3WJ Type1 200 - 501 None None 0
Homo sapiens TGFR1_HUMAN 4X2GA 1.51 Active DFGin BLAminus in-in in-in 3WK Type1 200 - 501 None None 0
Homo sapiens TGFR1_HUMAN 9J9DA 1.337 Active DFGin BLAminus in-in in-in A1L30 Type1 202 - 502 None None 2
Homo sapiens TGFR1_HUMAN 2WOTA 1.85 Active DFGin BLAminus in-in in-in ZZG Type1 200 - 500 None None 0
Homo sapiens TGFR1_HUMAN 2WOUA 2.3 Active DFGin BLAminus in-in in-in ZZF Type1 200 - 496 None None 0
Homo sapiens TGFR1_HUMAN 8YHLA 1.47 Active DFGin BLAminus in-in in-in A1D6I Type1 200 - 501 None None 0
Homo sapiens TGFR1_HUMAN 5E8WA 1.86 Active DFGin BLAminus in-in in-in STU Type1 200 - 501 T204D None 0
Homo sapiens TGFR1_HUMAN 5E8ZA 1.51 Active DFGin BLAminus in-in in-in 5L4 Type1 200 - 499 T204D None 0
Homo sapiens TGFR1_HUMAN 5QIKA 1.58 Active DFGin BLAminus in-in in-in J2M Type1 200 - 499 T204D None 0
Homo sapiens TGFR1_HUMAN 5QILA 1.98 Active DFGin BLAminus in-in in-in J2V Type1 200 - 499 T204D None 0
Homo sapiens TGFR1_HUMAN 5QTZA 1.83 Active DFGin BLAminus in-in in-in QMY Type1 200 - 499 T204D None 0
Homo sapiens TGFR1_HUMAN 5QU0A 1.67 Active DFGin BLAminus in-in in-in QMV Type1 200 - 502 T204D None 0
Homo sapiens TGFR1_HUMAN 3TZMA 1.7 Active DFGin BLAminus in-in in-in 085 Type1 200 - 496 None None 2
Homo sapiens TGFR1_HUMAN 1PY5A 2.3 Active DFGin BLAminus in-in in-in PY1 Type1 200 - 500 None None 0
Homo sapiens TGFR1_HUMAN 2X7OA 3.7 Active DFGin BLAminus in-in in-in ZOP Type1 171 - 500 None None 0
Homo sapiens TGFR1_HUMAN 2X7OB 3.7 Inactive DFGin BLAminus in-out in-in ZOP Type1 171 - 500 None None 0
Homo sapiens TGFR1_HUMAN 3FAAA 3.35 Active DFGin BLAminus in-in in-in 55F Type1 171 - 500 None None 2
Homo sapiens TGFR1_HUMAN 3FAAB 3.35 Active DFGin BLAminus in-in in-in 55F Type1 171 - 501 None None 3
Homo sapiens TGFR1_HUMAN 3FAAC 3.35 Active DFGin BLAminus in-in in-in 55F Type1 171 - 500 None None 0
Homo sapiens TGFR1_HUMAN 3FAAD 3.35 Active DFGin BLAminus in-in in-in 55F Type1 171 - 500 None None 0
Homo sapiens TGFR1_HUMAN 3FAAE 3.35 Active DFGin BLAminus in-in in-in 55F Type1 171 - 500 None None 0
Homo sapiens TGFR1_HUMAN 8YHFA 1.4 Active DFGin BLAminus in-in in-in A1D6I Type1 201 - 498 None None 0
Homo sapiens TGFR1_HUMAN 4X2JA 1.69 Active DFGin BLAminus in-in in-in 3WN Type1.5_Back 200 - 501 None None 0
Homo sapiens TGFR1_HUMAN 4X2KA 1.69 Active DFGin BLAminus in-in in-in 3WO Type1.5_Back 200 - 501 None None 0
Homo sapiens TGFR1_HUMAN 5QIMA 1.75 Active DFGin BLAminus in-in in-in J2Y Type1.5_Back 200 - 501 None None 0
Homo sapiens TGFR1_HUMAN 6B8YA 1.65 Active DFGin BLAminus in-in in-in D0A Type1.5_Back 200 - 502 T204D None 0
Homo sapiens TGFR1_HUMAN 2X7OC 3.7 Active DFGin BLAminus in-in in-in ZOP Type1.5_Back 171 - 500 None None 0
Homo sapiens TGFR1_HUMAN 2X7OD 3.7 Active DFGin BLAminus in-in in-in ZOP Type1.5_Back 171 - 500 None None 0
Homo sapiens TGFR1_HUMAN 2X7OE 3.7 Active DFGin BLAminus in-in in-in ZOP Type1.5_Back 171 - 500 None None 0
Homo sapiens TGFR1_HUMAN 3KCFA 2.8 Active DFGin BLAminus in-in in-in JZO Type1.5_Back 171 - 500 None None 2
Homo sapiens TGFR1_HUMAN 3KCFB 2.8 Active DFGin BLAminus in-in in-in JZO Type1.5_Back 171 - 501 None None 3
Homo sapiens TGFR1_HUMAN 3KCFC 2.8 Active DFGin BLAminus in-in in-in JZO Type1.5_Back 171 - 500 None None 0
Homo sapiens TGFR1_HUMAN 3KCFD 2.8 Active DFGin BLAminus in-in in-in JZO Type1.5_Back 171 - 500 None None 0
Homo sapiens TGFR1_HUMAN 3KCFE 2.8 Active DFGin BLAminus in-in in-in JZO Type1.5_Back 171 - 500 None None 0

TGFBR1 (TGF-beta receptor type-1)

No non-human structures known.