TYR_FGFR3 (Fibroblast growth factor receptor 3)

Total number of chains: 20
Active chains: 6
Uniprot: FGFR3_HUMAN
Kinase Domain Residues: 472 - 750
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 12 60.0% 9D1XA
DFGin BLAminus 7 35.0% AF-P22607-K1A
DFGin BLBplus 1 5.0% 8UDUA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
4K33A 2.341 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ACP ATPlike 459 - 755 0 None C482A,C582S,K650E Fibroblast growth factor receptor 3
AF-P22607-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 464 - 758 0 None None Fibroblast growth factor receptor 3
AF-P22607-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 464 - 758 0 None None Fibroblast growth factor receptor 3
6LVMA 2.53 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai EVR Type1.5_Back 472 - 755 0 PTR577,PTR647,PTR648 None Fibroblast growth factor receptor 3
7DHLA 2.57 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai H6X Type1.5_Back 472 - 755 0 PTR577,PTR647,PTR648 None Fibroblast growth factor receptor 3
8UDUB 1.737 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai WIQ Type1.5_Front 459 - 755 0 None P572S,P573G Fibroblast growth factor receptor 3
9KFUA 1.4 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai A1L5T Type1 448 - 756 0 None None Fibroblast growth factor receptor 3
6PNXA 2.199 Inactive DFGin‑BLAplus in-out out-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 456 - 757 0 None C482A,C582S,R669E Fibroblast growth factor receptor 3
6PNXB 2.199 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 455 - 756 0 None C482A,C582S,R669E Fibroblast growth factor receptor 3
8UDTA 2.829 Inactive DFGin‑BLAplus in-out out-out TYR APEdihe_nnoai APEdist_aaao MLT, MLT, WGF Allosteric, Allosteric, Type1.5_Front 457 - 756 0 None P572S,P573G Fibroblast growth factor receptor 3
9D1XA 1.6 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_iioai APEdist_aaao A1A6M Type1 461 - 754 0 None P572S,P573G Fibroblast growth factor receptor 3
9CD7A 2.53 Inactive DFGin‑BLAplus in-in none-out TYR APEdihe_nnoai APEdist_aaao A1AV2 Type1 451 - 755 0 None C482A,C582S,K650E Fibroblast growth factor receptor 3
9CD7B 2.53 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_nnoai APEdist_aaao A1AV2 Type1 458 - 755 0 None C482A,C582S,K650E Fibroblast growth factor receptor 3
9CD7C 2.53 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_nnoai APEdist_aaao A1AV2 Type1 458 - 755 0 None C482A,C582S,K650E Fibroblast growth factor receptor 3
8UDVA 2.348 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_iioai APEdist_aaao WIQ Type1.5_Back 458 - 755 0 None V555M Fibroblast growth factor receptor 3
8UDVB 2.348 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_iioai APEdist_aaao WIQ Type1.5_Back 455 - 755 0 None V555M Fibroblast growth factor receptor 3
8UDVC 2.348 Inactive DFGin‑BLAplus in-in none-out TYR APEdihe_nnoai APEdist_aaao WIQ Type1.5_Back 458 - 755 0 None V555M Fibroblast growth factor receptor 3
8UDTB 2.829 Inactive DFGin‑BLAplus in-out out-out TYR APEdihe_nooai APEdist_aaao WGF Type1.5_Front 457 - 754 0 None P572S,P573G Fibroblast growth factor receptor 3
8UDTC 2.829 Inactive DFGin‑BLAplus in-out out-out TYR APEdihe_nooai APEdist_aaao WGF Type1.5_Front 457 - 756 0 None P572S,P573G Fibroblast growth factor receptor 3
8UDUA 1.737 Inactive DFGin‑BLBplus in-in none-out TYR APEdihe_iiiai APEdist_aaao WIQ Type1.5_Back 460 - 756 0 None P572S,P573G Fibroblast growth factor receptor 3

TYR_FGFR3 (Fibroblast growth factor receptor 3)

Total number of chains: 20
Active chains: 6
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAplus 12 60.0% 9D1XA
DFGin BLAminus 7 35.0% AF-P22607-K1A
DFGin BLBplus 1 5.0% 8UDUA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
FGFR3_HUMAN 4K33A 2.341 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai ACP ATPlike 459 - 755 0 None C482A,C582S,K650E Fibroblast growth factor receptor 3 Homo sapiens
FGFR3_HUMAN AF-P22607-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 464 - 758 0 None None Fibroblast growth factor receptor 3 Homo sapiens
FGFR3_HUMAN AF-P22607-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 464 - 758 0 None None Fibroblast growth factor receptor 3 Homo sapiens
FGFR3_HUMAN 6LVMA 2.53 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai EVR Type1.5_Back 472 - 755 0 PTR577,PTR647,PTR648 None Fibroblast growth factor receptor 3 Homo sapiens
FGFR3_HUMAN 7DHLA 2.57 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai H6X Type1.5_Back 472 - 755 0 PTR577,PTR647,PTR648 None Fibroblast growth factor receptor 3 Homo sapiens
FGFR3_HUMAN 8UDUB 1.737 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai WIQ Type1.5_Front 459 - 755 0 None P572S,P573G Fibroblast growth factor receptor 3 Homo sapiens
FGFR3_HUMAN 9KFUA 1.4 Inactive DFGin‑BLAminus in-in in-out TYR APEdihe_oiiai APEdist_aaai A1L5T Type1 448 - 756 0 None None Fibroblast growth factor receptor 3 Homo sapiens
FGFR3_HUMAN 6PNXA 2.199 Inactive DFGin‑BLAplus in-out out-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 456 - 757 0 None C482A,C582S,R669E Fibroblast growth factor receptor 3 Homo sapiens
FGFR3_HUMAN 6PNXB 2.199 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_oiiai APEdist_aaai ACP ATPlike 455 - 756 0 None C482A,C582S,R669E Fibroblast growth factor receptor 3 Homo sapiens
FGFR3_HUMAN 8UDTA 2.829 Inactive DFGin‑BLAplus in-out out-out TYR APEdihe_nnoai APEdist_aaao MLT, MLT, WGF Allosteric, Allosteric, Type1.5_Front 457 - 756 0 None P572S,P573G Fibroblast growth factor receptor 3 Homo sapiens
FGFR3_HUMAN 9D1XA 1.6 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_iioai APEdist_aaao A1A6M Type1 461 - 754 0 None P572S,P573G Fibroblast growth factor receptor 3 Homo sapiens
FGFR3_HUMAN 9CD7A 2.53 Inactive DFGin‑BLAplus in-in none-out TYR APEdihe_nnoai APEdist_aaao A1AV2 Type1 451 - 755 0 None C482A,C582S,K650E Fibroblast growth factor receptor 3 Homo sapiens
FGFR3_HUMAN 9CD7B 2.53 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_nnoai APEdist_aaao A1AV2 Type1 458 - 755 0 None C482A,C582S,K650E Fibroblast growth factor receptor 3 Homo sapiens
FGFR3_HUMAN 9CD7C 2.53 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_nnoai APEdist_aaao A1AV2 Type1 458 - 755 0 None C482A,C582S,K650E Fibroblast growth factor receptor 3 Homo sapiens
FGFR3_HUMAN 8UDVA 2.348 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_iioai APEdist_aaao WIQ Type1.5_Back 458 - 755 0 None V555M Fibroblast growth factor receptor 3 Homo sapiens
FGFR3_HUMAN 8UDVB 2.348 Inactive DFGin‑BLAplus in-in out-out TYR APEdihe_iioai APEdist_aaao WIQ Type1.5_Back 455 - 755 0 None V555M Fibroblast growth factor receptor 3 Homo sapiens
FGFR3_HUMAN 8UDVC 2.348 Inactive DFGin‑BLAplus in-in none-out TYR APEdihe_nnoai APEdist_aaao WIQ Type1.5_Back 458 - 755 0 None V555M Fibroblast growth factor receptor 3 Homo sapiens
FGFR3_HUMAN 8UDTB 2.829 Inactive DFGin‑BLAplus in-out out-out TYR APEdihe_nooai APEdist_aaao WGF Type1.5_Front 457 - 754 0 None P572S,P573G Fibroblast growth factor receptor 3 Homo sapiens
FGFR3_HUMAN 8UDTC 2.829 Inactive DFGin‑BLAplus in-out out-out TYR APEdihe_nooai APEdist_aaao WGF Type1.5_Front 457 - 756 0 None P572S,P573G Fibroblast growth factor receptor 3 Homo sapiens
FGFR3_HUMAN 8UDUA 1.737 Inactive DFGin‑BLBplus in-in none-out TYR APEdihe_iiiai APEdist_aaao WIQ Type1.5_Back 460 - 756 0 None P572S,P573G Fibroblast growth factor receptor 3 Homo sapiens

TYR_FGFR3 (Fibroblast growth factor receptor 3)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism