Ligand: 6HL

Total number of chains: 2
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 50.0% 6QG7A
DFGin BLAminus 1 50.0% 5J9YA
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
STE MAP2K7 MP2K7_HUMAN 6QG7A 2.1 Inactive DFGin‑ABAminus na-na in-out nonTYR APEdihe_aaiai APEdist_nnoi 6HL Type1 102 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7
TYR EGFR EGFR_HUMAN 5J9YA 2.8 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 6HL Type1 697 - 1019 0 None None Epidermal growth factor receptor

Ligand: 6HL

Total number of chains: 2
Active chains: 1
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin ABAminus 1 50.0% 6QG7A
DFGin BLAminus 1 50.0% 5J9YA
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
STE MAP2K7 MP2K7_HUMAN 6QG7A 2.1 Inactive DFGin‑ABAminus na-na in-out nonTYR APEdihe_aaiai APEdist_nnoi 6HL Type1 102 - 401 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
TYR EGFR EGFR_HUMAN 5J9YA 2.8 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 6HL Type1 697 - 1019 0 None None Epidermal growth factor receptor Homo sapiens

Ligand: 6HL

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity_label Spatial_Dihedral_labels ChelixSaltbr_label ActLoopNT-ActLoopCT APEtype APEdihe_label APEdist_label Ligand Ligand_type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism