8FJZ

MAP4K1 (Mitogen-activated protein kinase kinase kinase kinase 1)
Group: STE
Uniprot: M4K1_HUMAN
Organism: Homo sapiens
Domain boundary: 17 - 274
Resolu: 1.897

Chain id Activity_label Spatial_label Dihedral_label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type Residues in structure Unresolved residues in A-loop
A Inactive DFGin BLAminus in-in out-out Y3I Type1 3 - 292 0
B None DFGin BLAminus in-in out-none Y3I Type1 5 - 292 4
C Inactive DFGin BLAminus in-in out-out Y3I Type1 5 - 292 0
D Inactive DFGin BLAminus in-in out-out Y3I Type1 5 - 292 5
E Inactive DFGin BLAminus in-in out-out Y3I Type1 6 - 292 0
F Inactive DFGin BLAminus in-in out-out Y3I Type1 9 - 292 0
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment 
Representative sequence - Chain F
         -          -          6         16 
mashhhhhhd ydgattenly fqgsmdvvdp diFNRDPRDH 
        26         36         46         56 
YDLLQRLGGG TYGEVFKARD KvsgDLVALK MVKmepddDV 
        66         76         86         96 
STLQKEILIL KTCRHANIVA YHGSYLWLQK LWICMEFCGA 
       106        116        126        136 
GSLQDIYQVT GSLSELQISY VCREVLQGLA YLHSQKKIHR 
       146        156        166        176 
DIKGANILIN DAGEVRLADF GISAQIGAEL ARRLEFIGTP 
       186        196        206        216 
YWMAPEVAAV ALKGGYNELC DIWSLGITAI ELAELQPPLF 
       226        236        246        256 
DVHPLRVLFL MTKSGYQPPR LKEKGKWSAA FHNFIKVTLT 
       266        276        286        296 
KSPKKRPSAT KMLSHQLVSQ PGLNRGLILD LLDKLKnpgk 
       306 
gpsigdiede e
Lower-case residues are disordered in structure.
Mutations: T165E,S171E
Phosphorylation: None