STE_MAP2K2 (Dual specificity mitogen-activated protein kinase kinase 2)

Total number of chains: 4
Active chains: 2
Uniprot: MP2K2_HUMAN
Kinase Domain Residues: 72 - 369
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 50.0% AF-P36507-K1A
DFGin BLBplus 2 50.0% 1S9IA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-P36507-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 64 - 377 0 None None Dual specificity mitogen-activated protein kinase kinase 2
AF-P36507-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 64 - 377 0 None None Dual specificity mitogen-activated protein kinase kinase 2
1S9IA 3.2 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_nnoo ATP, 5EA ATPlike, Type3 60 - 393 0 None None Dual specificity mitogen-activated protein kinase kinase 2
1S9IB 3.2 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoo APEdist_nnnn ATP, 5EA ATPlike, Type3 59 - 389 0 None None Dual specificity mitogen-activated protein kinase kinase 2

STE_MAP2K2 (Dual specificity mitogen-activated protein kinase kinase 2)

Total number of chains: 4
Active chains: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 50.0% AF-P36507-K1A
DFGin BLBplus 2 50.0% 1S9IA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
MP2K2_HUMAN AF-P36507-K1A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 64 - 377 0 None None Dual specificity mitogen-activated protein kinase kinase 2 Homo sapiens
MP2K2_HUMAN AF-P36507-K3A -1.0 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii No_ligand No_ligand 64 - 377 0 None None Dual specificity mitogen-activated protein kinase kinase 2 Homo sapiens
MP2K2_HUMAN 1S9IA 3.2 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aaoio APEdist_nnoo ATP, 5EA ATPlike, Type3 60 - 393 0 None None Dual specificity mitogen-activated protein kinase kinase 2 Homo sapiens
MP2K2_HUMAN 1S9IB 3.2 Inactive DFGin‑BLBplus out-out out-out nonTYR APEdihe_aanoo APEdist_nnnn ATP, 5EA ATPlike, Type3 59 - 389 0 None None Dual specificity mitogen-activated protein kinase kinase 2 Homo sapiens

STE_MAP2K2 (Dual specificity mitogen-activated protein kinase kinase 2)

Total number of chains: 0
Active chains: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism