Ligand: 8E8

Total number of chains: 2
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 1 50.0% 5P9JA
None None 1 50.0% 6YG2A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
STE MAP2K7 MP2K7_HUMAN 6YG2A 2.0 Inactive None‑None in-na out-none nonTYR APEdihe_aanai APEdist_nnnn 1E8, 8E8 Allosteric, Type1.5_Front 102 - 404 0 None None Dual specificity mitogen-activated protein kinase kinase 7
TYR BTK BTK_HUMAN 5P9JA 1.08 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 8E8 Type1.5_Back 394 - 659 0 None None Tyrosine-protein kinase BTK

Ligand: 8E8

Total number of chains: 2
Active chains: 0
Total number of genes: 2
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLBplus 1 50.0% 5P9JA
None None 1 50.0% 6YG2A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
STE MAP2K7 MP2K7_HUMAN 6YG2A 2.0 Inactive None‑None in-na out-none nonTYR APEdihe_aanai APEdist_nnnn 1E8, 8E8 Allosteric, Type1.5_Front 102 - 404 0 None None Dual specificity mitogen-activated protein kinase kinase 7 Homo sapiens
TYR BTK BTK_HUMAN 5P9JA 1.08 Inactive DFGin‑BLBplus out-out out-out TYR APEdihe_oiiai APEdist_aaao 8E8 Type1.5_Back 394 - 659 0 None None Tyrosine-protein kinase BTK Homo sapiens

Ligand: 8E8

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism