Ligand: IE8

Total number of chains: 5
Active chains: 2
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 80.0% 9FR5A
DFGin None 1 20.0% 9FT6A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
CMGC DYRK1A DYR1A_HUMAN 9FT6A 3.0 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaioi APEdist_iiii A1IE8 Type1 134 - 480 0 PTR321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A
CMGC GSK3B GSK3B_HUMAN 9FR5A 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1IE8 Type1 25 - 385 0 None None Glycogen synthase kinase-3 beta
CMGC GSK3B GSK3B_HUMAN 9FR5B 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1IE8 Type1 36 - 382 0 None None Glycogen synthase kinase-3 beta
STE MAP3K5 M3K5_HUMAN 4BIDA 2.8 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi IE8 Type1 670 - 939 0 None T838E Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 4BIDB 2.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooi IE8 Type1 670 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5

Ligand: IE8

Total number of chains: 5
Active chains: 2
Total number of genes: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 4 80.0% 9FR5A
DFGin None 1 20.0% 9FT6A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
CMGC DYRK1A DYR1A_HUMAN 9FT6A 3.0 Inactive DFGin‑None in-in out-out nonTYR APEdihe_aaioi APEdist_iiii A1IE8 Type1 134 - 480 0 PTR321 None Dual specificity tyrosine-phosphorylation-regulated kinase 1A Homo sapiens
CMGC GSK3B GSK3B_HUMAN 9FR5A 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1IE8 Type1 25 - 385 0 None None Glycogen synthase kinase-3 beta Homo sapiens
CMGC GSK3B GSK3B_HUMAN 9FR5B 2.3 Active DFGin‑BLAminus in-in in-in nonTYR APEdihe_aaiii APEdist_iiii A1IE8 Type1 36 - 382 0 None None Glycogen synthase kinase-3 beta Homo sapiens
STE MAP3K5 M3K5_HUMAN 4BIDA 2.8 Inactive DFGin‑BLAminus in-out in-out nonTYR APEdihe_aaiii APEdist_iooi IE8 Type1 670 - 939 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens
STE MAP3K5 M3K5_HUMAN 4BIDB 2.8 Inactive DFGin‑BLAminus in-in in-out nonTYR APEdihe_aaiii APEdist_nooi IE8 Type1 670 - 940 0 None T838E Mitogen-activated protein kinase kinase kinase 5 Homo sapiens

Ligand: IE8

Total number of chains: 0
Active chains: 0
Total number of genes: 0
Spatial label Dihedral label Number of Chains Percent Representative
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
Download database table as tsv Go to Advanced Page
Family Gene UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism