Protein kinases in complex with 627 (Danusertib)

Total number of genes: 4
Total number of chains: 10
Spatial Dihedral Chains Representative
DFGin BLAminus 5 4QO9A
DFGin BLBminus 1 5I9ZA
DFGinter None 4 8SSOA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
CAMK AURKA AURKA_HUMAN Aurora kinase A 8SSPA 2.6 Inactive DFGin BLAminus out-out in-in PDO 627 Allosteric Type1
CAMK AURKA AURKA_HUMAN Aurora kinase A 2J50A 3.0 Inactive DFGinter None out-out out-out 627 Type1
CAMK AURKA AURKA_HUMAN Aurora kinase A 2J50B 3.0 Inactive DFGinter None out-out out-out 627 Type1
CAMK AURKA AURKA_HUMAN Aurora kinase A 8SSOA 1.97 Inactive DFGinter None out-out out-out 627 Type1
CAMK AURKA AURKA_HUMAN Aurora kinase A 8SSOD 1.97 Inactive DFGinter None out-out out-none 627 Type1
STE STK24 STK24_HUMAN Serine/threonine-protein kinase 24 4QO9A 2.2 Active DFGin BLAminus in-in in-in 627 Type1
STE STK24 STK24_HUMAN Serine/threonine-protein kinase 24 4QO9B 2.2 Active DFGin BLAminus in-in in-in 627 Type1
TYR ABL1 ABL1_HUMAN Tyrosine-protein kinase ABL1 2V7AA 2.5 Active DFGin BLAminus in-in in-in 627 Type1
TYR ABL1 ABL1_HUMAN Tyrosine-protein kinase ABL1 2V7AB 2.5 Active DFGin BLAminus in-in in-in 627 Type1
TYR EPHA2 EPHA2_HUMAN Ephrin type-A receptor 2 5I9ZA 1.698 Inactive DFGin BLBminus in-in out-in 627 Type1

Protein kinases in complex with 627

Total number of genes: 4
Total number of chains: 10
Spatial Dihedral Chains Representative
DFGin BLAminus 5 4QO9A
DFGin BLBminus 1 5I9ZA
DFGinter None 4 8SSOA
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Homo sapiens CAMK AURKA AURKA_HUMAN Aurora kinase A 8SSPA 2.6 Inactive DFGin BLAminus out-out in-in PDO 627 Allosteric Type1
Homo sapiens CAMK AURKA AURKA_HUMAN Aurora kinase A 2J50A 3.0 Inactive DFGinter None out-out out-out 627 Type1
Homo sapiens CAMK AURKA AURKA_HUMAN Aurora kinase A 2J50B 3.0 Inactive DFGinter None out-out out-out 627 Type1
Homo sapiens CAMK AURKA AURKA_HUMAN Aurora kinase A 8SSOA 1.97 Inactive DFGinter None out-out out-out 627 Type1
Homo sapiens CAMK AURKA AURKA_HUMAN Aurora kinase A 8SSOD 1.97 Inactive DFGinter None out-out out-none 627 Type1
Homo sapiens STE STK24 STK24_HUMAN Serine/threonine-protein kinase 24 4QO9A 2.2 Active DFGin BLAminus in-in in-in 627 Type1
Homo sapiens STE STK24 STK24_HUMAN Serine/threonine-protein kinase 24 4QO9B 2.2 Active DFGin BLAminus in-in in-in 627 Type1
Homo sapiens TYR ABL1 ABL1_HUMAN Tyrosine-protein kinase ABL1 2V7AA 2.5 Active DFGin BLAminus in-in in-in 627 Type1
Homo sapiens TYR ABL1 ABL1_HUMAN Tyrosine-protein kinase ABL1 2V7AB 2.5 Active DFGin BLAminus in-in in-in 627 Type1
Homo sapiens TYR EPHA2 EPHA2_HUMAN Ephrin type-A receptor 2 5I9ZA 1.698 Inactive DFGin BLBminus in-in out-in 627 Type1

Protein kinases in complex with 627

Total number of genes: 0
Total number of chains: 0
Spatial Dihedral Chains Representative
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type