TYR_ABL2 (Tyrosine-protein kinase ABL2)

Total number of chains: 7
Active chains: 2
Uniprot: ABL2_HUMAN
Kinase Domain Residues: 288 - 541
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 5 71.4% AF-P42684-K1A
DFGinter None 1 14.3% 3HMIA
DFGout BBAminus 1 14.3% 3GVUA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein
AF-P42684-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 280 - 549 0 None None Tyrosine-protein kinase ABL2
AF-P42684-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 280 - 549 0 None None Tyrosine-protein kinase ABL2
3HMIA 1.65 Inactive DFGinter‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai DKI Type1 279 - 546 0 None None Tyrosine-protein kinase ABL2
3GVUA 2.05 Inactive DFGout‑BBAminus in-in out-none TYR APEdihe_niiai APEdist_aaai STI, STI Type2, Allosteric 279 - 546 0 None None Tyrosine-protein kinase ABL2
2XYNA 2.81 None DFGin‑BLAminus in-none in-in TYR APEdihe_iiiai APEdist_aaai VX6 Type1 280 - 545 0 None None Tyrosine-protein kinase ABL2
2XYNB 2.81 None DFGin‑BLAminus in-none in-in TYR APEdihe_iiiai APEdist_aaai VX6, VX6, VX6 Type1, Allosteric, Allosteric 280 - 545 0 None None Tyrosine-protein kinase ABL2
2XYNC 2.81 None DFGin‑BLAminus in-none in-in TYR APEdihe_iiiai APEdist_aaai VX6, VX6, VX6 Type1, Allosteric, Allosteric 281 - 544 0 None None Tyrosine-protein kinase ABL2

TYR_ABL2 (Tyrosine-protein kinase ABL2)

Total number of chains: 9
Active chains: 3
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 7 77.8% AF-P42684-K1A
DFGinter None 1 11.1% 3HMIA
DFGout BBAminus 1 11.1% 3GVUA
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
ABL2_HUMAN AF-P42684-K1A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 280 - 549 0 None None Tyrosine-protein kinase ABL2 Homo sapiens
ABL2_HUMAN AF-P42684-K3A -1.0 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai No_ligand No_ligand 280 - 549 0 None None Tyrosine-protein kinase ABL2 Homo sapiens
ABL2_HUMAN 3HMIA 1.65 Inactive DFGinter‑None in-in out-in TYR APEdihe_iiiai APEdist_aaai DKI Type1 279 - 546 0 None None Tyrosine-protein kinase ABL2 Homo sapiens
ABL2_HUMAN 3GVUA 2.05 Inactive DFGout‑BBAminus in-in out-none TYR APEdihe_niiai APEdist_aaai STI, STI Type2, Allosteric 279 - 546 0 None None Tyrosine-protein kinase ABL2 Homo sapiens
ABL2_HUMAN 2XYNA 2.81 None DFGin‑BLAminus in-none in-in TYR APEdihe_iiiai APEdist_aaai VX6 Type1 280 - 545 0 None None Tyrosine-protein kinase ABL2 Homo sapiens
ABL2_HUMAN 2XYNB 2.81 None DFGin‑BLAminus in-none in-in TYR APEdihe_iiiai APEdist_aaai VX6, VX6, VX6 Type1, Allosteric, Allosteric 280 - 545 0 None None Tyrosine-protein kinase ABL2 Homo sapiens
ABL2_HUMAN 2XYNC 2.81 None DFGin‑BLAminus in-none in-in TYR APEdihe_iiiai APEdist_aaai VX6, VX6, VX6 Type1, Allosteric, Allosteric 281 - 544 0 None None Tyrosine-protein kinase ABL2 Homo sapiens
ABL2_MOUSE 4XLIB 2.5 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 1N1 Type1.5_Back 279 - 546 0 None None Tyrosine-protein kinase ABL2 Mus musculus
ABL2_MOUSE 4XLIA 2.5 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai 1N1 Type1.5_Back 279 - 546 0 None None Tyrosine-protein kinase ABL2 Mus musculus

TYR_ABL2 (Tyrosine-protein kinase ABL2)

Total number of chains: 2
Active chains: 1
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 2 100.0% 4XLIB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment
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UniprotID PDB Resolution Activity Spatial-Dihedral Chelix-SaltBridge ActLoopNT-ActLoopCT APEtype APEdihe APEdist Ligand Ligand Type Residues in structure Unresolved residues in A-loop Phosphorylation Mutation Protein Organism
ABL2_MOUSE 4XLIB 2.5 Active DFGin‑BLAminus in-in in-in TYR APEdihe_iiiai APEdist_aaai 1N1 Type1.5_Back 279 - 546 0 None None Tyrosine-protein kinase ABL2 Mus musculus
ABL2_MOUSE 4XLIA 2.5 Inactive DFGin‑BLAminus in-out in-in TYR APEdihe_iiiai APEdist_aaai 1N1 Type1.5_Back 279 - 546 0 None None Tyrosine-protein kinase ABL2 Mus musculus