Protein kinases in complex with IRE (Gefitinib)

Total number of genes: 2
Total number of chains: 9
Spatial Dihedral Chains Representative
DFGin BLAminus 5 4WKQA
DFGin ABAminus 3 5Y7ZA
DFGin BLBtrans 1 4I22A
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
OTHER GAK GAK_HUMAN Cyclin-G-associated kinase 5Y7ZA 2.804 Inactive DFGin ABAminus in-in in-in IRE Type1
OTHER GAK GAK_HUMAN Cyclin-G-associated kinase 5Y7ZB 2.804 Inactive DFGin ABAminus in-in in-in IRE Type1
OTHER GAK GAK_HUMAN Cyclin-G-associated kinase 5Y80A 2.5 Inactive DFGin ABAminus in-in in-out IRE IRE Type1 Allosteric
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 3UG2A 2.5 Inactive DFGin BLAminus in-out in-in IRE Type1
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 2ITYA 3.42 Active DFGin BLAminus in-in in-in IRE Type1
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 4WKQA 1.85 Active DFGin BLAminus in-in in-in IRE Type1
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 2ITOA 3.25 Active DFGin BLAminus in-in in-in IRE Type1
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 2ITZA 2.8 Inactive DFGin BLAminus in-out in-in IRE Type1
TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 4I22A 1.71 Inactive DFGin BLBtrans out-out out-out IRE Type1

Protein kinases in complex with IRE

Total number of genes: 2
Total number of chains: 9
Spatial Dihedral Chains Representative
DFGin BLAminus 5 4WKQA
DFGin ABAminus 3 5Y7ZA
DFGin BLBtrans 1 4I22A
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv
Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type
Homo sapiens OTHER GAK GAK_HUMAN Cyclin-G-associated kinase 5Y7ZA 2.804 Inactive DFGin ABAminus in-in in-in IRE Type1
Homo sapiens OTHER GAK GAK_HUMAN Cyclin-G-associated kinase 5Y7ZB 2.804 Inactive DFGin ABAminus in-in in-in IRE Type1
Homo sapiens OTHER GAK GAK_HUMAN Cyclin-G-associated kinase 5Y80A 2.5 Inactive DFGin ABAminus in-in in-out IRE IRE Type1 Allosteric
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 3UG2A 2.5 Inactive DFGin BLAminus in-out in-in IRE Type1
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 2ITYA 3.42 Active DFGin BLAminus in-in in-in IRE Type1
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 4WKQA 1.85 Active DFGin BLAminus in-in in-in IRE Type1
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 2ITOA 3.25 Active DFGin BLAminus in-in in-in IRE Type1
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 2ITZA 2.8 Inactive DFGin BLAminus in-out in-in IRE Type1
Homo sapiens TYR EGFR EGFR_HUMAN Epidermal growth factor receptor 4I22A 1.71 Inactive DFGin BLBtrans out-out out-out IRE Type1

Protein kinases in complex with IRE

Total number of genes: 0
Total number of chains: 0
Spatial Dihedral Chains Representative
All chains
Pymol session(ver 2.3) Pymol script
All chains - renumbered by
Uniprot PDB Alignment
Database table as tsv

Organism Group Gene UniprotID Protein PDB Resolu Activity Label Spatial Label Dihedral Label Chelix-SaltBridge ActLoopNT-ActLoopCT Ligand Type