All / DFGinter / All

Total number of chains: 231
Active chains: 0
Total number of genes: 45
Spatial label Dihedral label Number of Chains Percent Representative
DFGinter None 207 89.6% 4U3YA
DFGinter BABtrans 24 10.4% 7YC9A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Asp
χ1,χ2		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC ROCK1 ROCK1_HUMAN 3TWJB Q13464 8 402 1354.0 No_ligand No_ligand Inactive DFGinter 10.815 7.295 None DFGAsp-rot-in -140.02, 177.72 -138.03, 117.9 222.7, -23.05 -134.18, -179.7 267.51, 14.98 -75.11, 143.68 in-in in 8.042 Saltbr-in 3.562 HRD-in -70.23, -44.84 80.45, -14.54 in-out-out SNCioo out-out ActLoopNT-out 20.375 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -116.17, 145.08 APE9-dihe-na 57.93, -141.29 APE8-dihe-in -142.15, 148.38 APE8-rot-out 101.8 APE67-dihe-in -61.61, -39.57 -51.91, -51.11 APE12-dist-in 11.787 APE11-dist-in 13.034 APE10-dist-out 12.316 APE9-dist-in 4.196 None None None XRAY 2.9 0.224 0.289 B 410 395 0 0 0 0 [[76, 338]] 1.0 3twj AGC_ROCK1_HUMAN AGC 3.5e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 3TWJD Q13464 8 402 1354.0 No_ligand No_ligand Inactive DFGinter 10.79 6.927 None DFGAsp-rot-in -126.16, 176.03 -134.68, 123.87 202.81, -39.78 -143.34, -165.47 284.96, 15.3 -95.64, -168.75 in-in in 8.257 Saltbr-in 2.943 HRD-in -49.62, -47.32 79.16, -22.55 in-out-out SNCioo out-out ActLoopNT-out 20.397 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na 45.48, 65.51 APE9-dihe-na 78.31, -176.86 APE8-dihe-in -88.74, 143.63 APE8-rot-out 17.15 APE67-dihe-in -61.11, -33.54 -55.29, -47.59 APE12-dist-in 9.993 APE11-dist-in 10.777 APE10-dist-out 10.945 APE9-dist-in 5.297 None None None XRAY 2.9 0.224 0.289 D 410 395 0 0 0 0 [[76, 338]] 1.0 3twj AGC_ROCK1_HUMAN AGC 3.5e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOC P51812 46 347 740.0 ANP:401 ATPlike Inactive DFGinter 5.815 10.993 None DFGAsp-rot-in -75.13, -10.43 -146.35, 169.25 199.75, -26.56 -135.79, 44.23 43.29, 81.79 87.07, 14.29 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.74, -32.6 74.07, -63.87 none-out-out SNCnoo out-out ActLoopNT-out 10.165 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -61.13, 122.89 APE9-dihe-na 75.62, 166.95 APE8-dihe-in -113.03, 115.92 APE8-rot-out 46.3 APE67-dihe-in -62.7, -36.2 -57.15, -32.55 APE12-dist-out 16.312 APE11-dist-out 16.934 APE10-dist-out 13.494 APE9-dist-out 6.87 None None None XRAY 2.75 0.209 0.232 C 317 295 7 0 0 0 [[68, 327], [422, 679]] 2.0 7opo AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOG P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGinter 6.68 10.963 None DFGAsp-rot-in -75.68, -10.29 -146.32, 168.68 199.8, -24.84 -137.91, 45.72 44.25, 84.07 86.95, 15.93 out-out out 19.338 Saltbr-out 19.753 HRD-in -66.3, -31.74 74.35, -64.56 out-out-out SNCooo out-out ActLoopNT-out 10.112 ActLoopCT-out nonTYR APEdihe_aanni APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 105.02 APE8-rot-none 999.0 APE67-dihe-in -58.75, -33.49 -86.55, -15.46 APE12-dist-out 16.986 APE11-dist-out 17.767 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 G 317 301 2 0 0 2 [[68, 327], [422, 679]] 2.0 7opo AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA5-1 KS6A5_HUMAN 1VZOA O75582 24 345 802.0 No_ligand No_ligand Inactive DFGinter 7.012 10.857 None DFGAsp-rot-out -86.08, 7.16 -135.82, 179.44 269.56, -63.77 -156.19, 30.86 46.84, 81.68 100.81, 7.87 out-out out 18.111 Saltbr-out 19.343 HRD-in -69.35, -43.67 69.6, -31.81 out-out-out SNCooo out-out ActLoopNT-out 10.263 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -83.3, -23.05 APE9-dihe-na -99.28, -166.51 APE8-dihe-in -67.08, 145.98 APE8-rot-out 174.8 APE67-dihe-in -63.46, -19.35 -108.6, 7.57 APE12-dist-in 13.98 APE11-dist-out 18.829 APE10-dist-out 17.834 APE9-dist-out 11.153 S212D None None XRAY 1.8 0.208 0.242 A 355 319 3 0 0 0 [[49, 318], [423, 687]] 2.0 1vzo AGC_RPS6KA5-1_HUMAN AGC 7.3e-93 316.4 1 260 260 194 195 196 198 200 81 101 105 174 176 175 177 237 223 218 217 216 215 214 213 212 132 Ribosomal protein S6 kinase alpha-5
AGC RPS6KA6-1 KS6A6_HUMAN 6G76B Q9UK32 51 349 745.0 ANP:401 ATPlike Inactive DFGinter 5.797 10.982 None DFGAsp-rot-in -66.14, -24.76 -146.8, 171.15 184.14, 24.57 -130.39, 64.5 31.65, 91.02 69.21, 34.12 none-none none 999.0 Saltbr-none 999.0 HRD-in -64.7, -28.83 65.1, -58.97 none-out-none SNCnon out-none ActLoopNT-out 9.714 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -65.75, -19.3 999.0, -17.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP232 SEP232 XRAY 3.0 0.226 0.268 B 307 269 30 0 0 11 [[73, 330], [426, 683]] 2.0 6g76 AGC_RPS6KA6-1_HUMAN AGC 1.2e-97 332.1 1 260 260 215 216 217 219 221 105 123 127 195 197 196 198 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G78A Q9UK32 51 349 745.0 ANP:401 ATPlike Inactive DFGinter 6.269 10.634 None DFGAsp-rot-in -86.41, -10.47 -141.48, -170.45 212.36, -52.29 -156.88, 52.15 42.27, 88.32 84.48, 16.59 none-none none 999.0 Saltbr-none 999.0 HRD-in -69.26, -28.88 63.94, -61.25 none-out-out SNCnoo out-out ActLoopNT-out 9.59 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 82.23 APE8-dihe-out 57.69, 79.35 APE8-rot-in 324.77 APE67-dihe-in -47.93, -24.91 -65.59, -33.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 7.912 S232E None None XRAY 2.5 0.227 0.24 A 307 283 16 0 0 8 [[73, 330], [426, 683]] 2.0 6g78 AGC_RPS6KA6-1_HUMAN AGC 1.4e-97 331.8 1 260 260 215 216 217 219 221 105 123 127 195 197 196 198 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G78B Q9UK32 51 349 745.0 ANP:401 ATPlike Inactive DFGinter 5.64 10.738 None DFGAsp-rot-in -79.92, -10.17 -139.49, -179.53 209.54, -48.65 -146.16, 53.91 40.8, 75.5 84.23, 17.04 none-none none 999.0 Saltbr-none 999.0 HRD-in -71.51, -26.87 55.09, -79.87 none-out-out SNCnoo out-out ActLoopNT-out 9.839 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -162.93 APE8-dihe-in -60.6, 118.59 APE8-rot-in 321.37 APE67-dihe-in -66.02, -21.47 -64.56, -33.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.845 S232E None None XRAY 2.5 0.227 0.24 B 307 281 18 0 0 10 [[73, 330], [426, 683]] 2.0 6g78 AGC_RPS6KA6-1_HUMAN AGC 1.4e-97 331.8 1 260 260 215 216 217 219 221 105 123 127 195 197 196 198 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G76A Q9UK32 51 349 745.0 ANP:401,ANP:402 ATPlike,Allosteric Inactive DFGinter 6.261 10.877 None DFGAsp-rot-in -85.39, -13.66 -143.61, 178.12 202.81, -28.93 -143.21, 50.96 33.86, 88.85 75.03, 27.38 none-none none 999.0 Saltbr-none 999.0 HRD-in -70.26, -5.92 45.43, -59.01 none-out-out SNCnoo out-out ActLoopNT-out 9.842 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 52.64, -135.92 APE9-dihe-na -103.88, -148.96 APE8-dihe-in -100.12, 127.8 APE8-rot-in 306.8 APE67-dihe-in -56.57, -28.02 -70.04, -37.97 APE12-dist-in 13.909 APE11-dist-out 16.247 APE10-dist-out 12.746 APE9-dist-in 5.596 None SEP232 SEP232 XRAY 3.0 0.226 0.268 A 307 291 8 0 0 0 [[73, 330], [426, 683]] 2.0 6g76 AGC_RPS6KA6-1_HUMAN AGC 1.2e-97 332.1 1 260 260 215 216 217 219 221 105 123 127 195 197 196 198 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC SGK1 SGK1_HUMAN 2R5TA O00141 82 378 431.0 ANP:500 ATPlike Inactive DFGinter 10.249 5.74 None DFGAsp-rot-in -86.79, -16.14 -72.2, 135.26 187.88, -80.22 -125.95, 20.0 58.26, 94.07 102.37, 6.12 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.44, -44.78 83.3, -51.0 none-out-out SNCnoo out-out ActLoopNT-out 9.243 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na 54.74, 50.94 APE9-dihe-na -69.27, 152.13 APE8-dihe-in -51.76, 128.99 APE8-rot-in 305.39 APE67-dihe-out -166.98, 160.95 -53.6, 132.16 APE12-dist-out 29.883 APE11-dist-out 30.65 APE10-dist-out 28.034 APE9-dist-out 16.248 S74A,S78A,S397A,S401A None None XRAY 1.9 0.193 0.215 A 373 284 13 0 0 0 [[98, 355]] 1.0 2r5t AGC_SGK1_HUMAN AGC 4.7e-99 336.7 1 260 260 239 240 241 243 245 127 146 150 219 221 220 222 279 267 262 261 260 259 258 257 256 177 Serine/threonine-protein kinase Sgk1
AGC SGK1 SGK1_HUMAN 3HDMA O00141 81 378 431.0 MMG:500 Type1 Inactive DFGinter 9.977 5.743 None DFGAsp-rot-in -83.68, -7.68 -69.69, 128.31 171.02, 79.94 -122.03, 7.18 59.85, 94.45 118.71, -0.25 none-none none 999.0 Saltbr-none 999.0 HRD-in -68.93, -38.18 84.66, -53.42 none-out-out SNCnoo out-out ActLoopNT-out 7.78 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na 56.48, 64.87 APE9-dihe-na -77.63, -170.21 APE8-dihe-in -69.51, 134.86 APE8-rot-in 310.86 APE67-dihe-out -140.61, 157.94 -65.57, 107.15 APE12-dist-out 30.439 APE11-dist-out 31.121 APE10-dist-out 28.385 APE9-dist-out 16.422 S74A,S78A,S397A,S401A None None XRAY 2.6 0.22 0.262 A 373 285 13 0 0 0 [[98, 355]] 1.0 3hdm AGC_SGK1_HUMAN AGC 4.7e-99 336.7 1 260 260 239 240 241 243 245 127 146 150 219 221 220 222 279 267 262 261 260 259 258 257 256 177 Serine/threonine-protein kinase Sgk1
AGC SGK1 SGK1_HUMAN 3HDNA O00141 82 374 431.0 GMG:1 Type1 Inactive DFGinter 10.684 6.059 None DFGAsp-rot-in -80.54, -17.07 -64.88, 127.58 192.2, -65.6 -123.29, -5.01 55.66, 91.25 125.69, 15.03 none-none none 999.0 Saltbr-none 999.0 HRD-in -68.11, -29.45 73.47, -60.84 none-out-out SNCnoo out-out ActLoopNT-out 8.284 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na 56.04, 66.32 APE9-dihe-na -71.14, 173.43 APE8-dihe-in -68.52, 127.58 APE8-rot-in 307.02 APE67-dihe-out -159.22, 150.57 -56.04, 117.71 APE12-dist-out 30.099 APE11-dist-out 30.865 APE10-dist-out 28.034 APE9-dist-out 16.482 S74A,S78A,S397A,S401A None None XRAY 3.1 0.251 0.278 A 373 280 13 0 0 0 [[98, 355]] 1.0 3hdn AGC_SGK1_HUMAN AGC 4.7e-99 336.7 1 260 260 239 240 241 243 245 127 146 150 219 221 220 222 279 267 262 261 260 259 258 257 256 177 Serine/threonine-protein kinase Sgk1
CAMK AURKA AURKA_HUMAN 4C3RA O14965 127 388 403.0 ACP:1389 ATPlike Inactive DFGinter 6.087 8.639 None DFGAsp-rot-out -114.31, -7.36 -87.64, 130.6 111.26, 78.11 -72.8, -47.16 285.43, 29.08 69.28, 138.63 out-out out 11.963 Saltbr-out 7.785 HRD-out -148.79, 112.09 -68.12, -80.01 out-out-out SNCooo out-out ActLoopNT-out 8.017 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 137.49 APE8-dihe-in -74.84, 138.8 APE8-rot-out 199.32 APE67-dihe-in -50.64, -36.72 -89.13, -8.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.231 None None None XRAY 2.79 0.229 0.306 A 282 252 10 0 0 10 [[133, 383]] 1.0 4c3r CAMK_AURKA_HUMAN CAMK 7.6e-80 273.9 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6C83B O14965 127 388 403.0 ACP:501 ATPlike Inactive DFGinter 7.317 8.588 None DFGAsp-rot-in -129.69, 90.85 -100.04, 101.37 198.57, -2.88 -135.34, 999.0 303.1, 99.49 999.0, 999.0 out-out out 12.115 Saltbr-out 10.049 HRD-out -96.09, 116.19 -110.78, 111.97 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -90.23 APE8-dihe-out -77.58, -0.58 APE8-rot-out 85.03 APE67-dihe-in -69.49, -5.14 -61.84, -44.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.472 None None None XRAY 2.55 0.268 0.322 B 285 247 15 0 0 15 [[133, 383]] 1.0 6c83 CAMK_AURKA_HUMAN CAMK 7.9e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5L8JA O14965 126 391 403.0 ADP:60501 ATPlike Inactive DFGinter 6.039 8.812 None DFGAsp-rot-out -121.42, -0.81 -92.81, -3.45 64.76, -20.58 60.99, 19.44 297.14, 26.84 -77.84, 60.22 out-out out 13.201 Saltbr-out 9.588 HRD-out -100.39, 154.9 -77.66, -154.82 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 16.48 APE8-rot-out 62.75 APE67-dihe-in -57.65, -20.32 -54.21, -40.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C290A,C393A TPO288 TPO288 XRAY 1.68 0.201 0.231 A 285 253 13 0 0 13 [[133, 383]] 1.0 5l8j CAMK_AURKA_HUMAN CAMK 9.7e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5L8KA O14965 126 392 403.0 ADP:60501 ATPlike Inactive DFGinter 5.934 8.696 None DFGAsp-rot-out -123.53, 3.87 -94.88, 4.13 68.21, -25.72 51.12, 25.43 307.6, 8.65 -83.23, 69.32 out-out out 12.906 Saltbr-out 9.137 HRD-out -94.24, 154.96 -82.75, -161.39 out-out-out SNCooo out-out ActLoopNT-out 5.262 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -60.54, 152.13 APE9-dihe-na 121.57, -104.82 APE8-dihe-in -138.45, 120.03 APE8-rot-in 300.38 APE67-dihe-in -56.47, -22.96 -75.46, -21.38 APE12-dist-out 14.19 APE11-dist-out 17.885 APE10-dist-out 19.722 APE9-dist-out 13.729 C290A,C393A TPO288 TPO288 XRAY 1.79 0.192 0.235 A 285 267 0 0 0 0 [[133, 383]] 1.0 5l8k CAMK_AURKA_HUMAN CAMK 9.7e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5L8LA O14965 126 389 403.0 ADP:60501 ATPlike Inactive DFGinter 5.647 8.882 None DFGAsp-rot-out -117.8, 6.57 -92.89, -1.12 55.43, 31.52 53.22, 20.44 289.58, 36.26 -84.0, 68.46 out-out out 12.54 Saltbr-out 9.027 HRD-out -99.09, 148.91 -94.35, -164.8 out-out-out SNCooo out-out ActLoopNT-out 5.393 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -75.26, -165.41 APE9-dihe-na -67.89, -63.26 APE8-dihe-out -124.39, -179.64 APE8-rot-out 64.28 APE67-dihe-in -57.8, -26.84 -83.02, -0.31 APE12-dist-in 11.109 APE11-dist-out 16.52 APE10-dist-out 14.491 APE9-dist-out 14.639 C290A,C393A TPO288 TPO288 XRAY 1.67 0.193 0.223 A 285 264 0 0 0 0 [[133, 383]] 1.0 5l8l CAMK_AURKA_HUMAN CAMK 9.7e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8PR7A O14965 124 389 403.0 ADP:501 ATPlike Inactive DFGinter 5.07 10.273 None DFGAsp-rot-none -105.95, 148.75 -124.79, 28.7 999.0, 999.0 -129.06, 999.0 303.51, 120.23 999.0, 999.0 out-out out 12.482 Saltbr-out 11.706 HRD-out 52.78, 71.6 -97.43, 142.22 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 47.95, -115.05 APE9-dihe-na -125.01, 9.37 APE8-dihe-out -40.29, -50.01 APE8-rot-out 85.86 APE67-dihe-in -55.11, -34.07 -62.49, -38.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.832 D274N,C290A,N332A,Q335A,T347A,D350A,C393A None None XRAY 2.76 0.205 0.256 A 283 253 13 0 0 13 [[133, 383]] 1.0 8pr7 CAMK_AURKA_HUMAN CAMK 3.1e-77 265.4 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6XKAA O14965 127 388 403.0 No_ligand No_ligand Inactive DFGinter 8.929 7.51 None DFGAsp-rot-out -127.13, 56.47 -140.31, 176.96 57.25, 0.14 -101.27, 7.78 308.94, 105.52 -69.78, 61.67 out-out out 12.632 Saltbr-out 9.019 HRD-out -107.58, 148.94 -95.64, -139.96 out-out-out SNCooo out-out ActLoopNT-out 5.415 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -48.95 APE8-dihe-out -61.69, -24.7 APE8-rot-in 274.82 APE67-dihe-in -56.0, -24.76 -53.72, -21.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 35.053 None None None XRAY 2.65 0.226 0.279 A 292 252 10 0 0 10 [[133, 383]] 1.0 6xka CAMK_AURKA_HUMAN CAMK 8.6e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2WTVA O14965 125 389 403.0 ZZL:1390 Type1 Inactive DFGinter 5.701 9.454 None DFGAsp-rot-out -75.22, 156.08 -105.21, 156.98 313.97, -45.77 57.55, 45.32 319.02, 110.91 -59.58, -21.68 out-out out 12.224 Saltbr-out 9.738 HRD-out 56.62, 39.51 -65.34, 136.35 out-out-out SNCooo out-out ActLoopNT-out 17.312 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -58.52, -47.8 APE9-dihe-na -54.18, -45.12 APE8-dihe-out -70.51, -43.3 APE8-rot-in 297.14 APE67-dihe-in -48.3, -25.92 -57.93, -45.43 APE12-dist-in 8.287 APE11-dist-in 12.32 APE10-dist-out 15.039 APE9-dist-out 12.589 L215R,T217E,R220K TPO287,TPO288 TPO287,TPO288,CME290 XRAY 2.4 0.167 0.211 A 285 265 0 0 0 0 [[133, 383]] 1.0 2wtv CAMK_AURKA_HUMAN CAMK 2.8e-81 278.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2WTVB O14965 126 389 403.0 ZZL:1390 Type1 Inactive DFGinter 5.619 9.422 None DFGAsp-rot-out -74.68, 158.58 -101.8, 146.26 307.99, -36.18 63.97, 49.3 317.28, 114.07 -55.55, -26.4 out-out out 12.419 Saltbr-out 10.297 HRD-out -138.44, 123.91 -119.97, 134.75 out-out-out SNCooo out-out ActLoopNT-out 19.511 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na 85.02, 1.5 APE9-dihe-na 116.84, -135.44 APE8-dihe-in -82.25, 112.82 APE8-rot-in 306.92 APE67-dihe-in -64.29, -12.84 -49.83, -55.07 APE12-dist-out 14.754 APE11-dist-out 14.75 APE10-dist-out 12.235 APE9-dist-out 12.287 L215R,T217E,R220K TPO287,TPO288 TPO287,TPO288,CME290 XRAY 2.4 0.167 0.211 B 285 264 0 0 0 0 [[133, 383]] 1.0 2wtv CAMK_AURKA_HUMAN CAMK 2.8e-81 278.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2WTVC O14965 126 389 403.0 ZZL:1392 Type1 Inactive DFGinter 5.656 9.361 None DFGAsp-rot-out -73.47, 155.34 -96.85, 146.28 309.15, -45.1 67.08, 43.87 316.19, 116.1 -46.77, -31.93 out-out out 12.389 Saltbr-out 10.306 HRD-out -138.88, 125.11 -124.14, 137.81 out-out-out SNCooo out-out ActLoopNT-out 19.519 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na 85.46, 1.21 APE9-dihe-na 119.13, -135.87 APE8-dihe-in -82.97, 108.09 APE8-rot-in 299.33 APE67-dihe-in -62.27, -12.5 -42.96, -58.15 APE12-dist-out 14.766 APE11-dist-out 14.728 APE10-dist-out 12.267 APE9-dist-out 12.403 L215R,T217E,R220K TPO287,TPO288 TPO287,TPO288,CME290 XRAY 2.4 0.167 0.211 C 285 264 0 0 0 0 [[133, 383]] 1.0 2wtv CAMK_AURKA_HUMAN CAMK 2.8e-81 278.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2WTVD O14965 125 389 403.0 ZZL:1390 Type1 Inactive DFGinter 5.688 9.447 None DFGAsp-rot-out -74.49, 159.41 -108.43, 161.13 315.19, -46.47 55.07, 43.29 317.21, 115.65 -58.54, -27.22 out-out out 12.194 Saltbr-out 9.796 HRD-out 49.31, 42.91 -68.48, 131.43 out-out-out SNCooo out-out ActLoopNT-out 17.059 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -57.61, -41.18 APE9-dihe-na -56.01, -51.32 APE8-dihe-out -76.54, -36.16 APE8-rot-out 70.56 APE67-dihe-in -47.19, -33.07 -56.26, -46.95 APE12-dist-in 8.314 APE11-dist-in 12.48 APE10-dist-out 15.096 APE9-dist-out 12.493 L215R,T217E,R220K TPO287,TPO288 TPO287,TPO288,CME290 XRAY 2.4 0.167 0.211 D 285 265 0 0 0 0 [[133, 383]] 1.0 2wtv CAMK_AURKA_HUMAN CAMK 2.8e-81 278.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5EW9A O14965 127 390 403.0 5VC:1000 Type1 Inactive DFGinter 7.143 9.146 None DFGAsp-rot-in -125.76, 68.03 -116.07, 111.14 166.84, 28.94 -114.04, 30.21 299.83, 98.64 76.42, 31.17 out-out out 12.208 Saltbr-out 14.928 HRD-out 51.87, 61.64 -81.46, 128.2 out-out-out SNCooo out-out ActLoopNT-out 13.179 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -81.31, 136.15 APE9-dihe-na 106.85, -151.62 APE8-dihe-in -130.38, 126.41 APE8-rot-in 294.67 APE67-dihe-in -61.4, -16.67 -41.18, -56.68 APE12-dist-in 12.108 APE11-dist-in 12.375 APE10-dist-out 8.754 APE9-dist-out 7.261 None TPO287,TPO288 TPO287,TPO288 XRAY 2.181 0.191 0.237 A 271 259 5 0 0 5 [[133, 383]] 1.0 5ew9 CAMK_AURKA_HUMAN CAMK 6.5e-80 274.1 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6C2RA O14965 128 389 403.0 EG7:404 Type1 Inactive DFGinter 9.162 6.987 None DFGAsp-rot-out -129.68, 71.59 -143.19, 175.42 54.91, 28.28 -111.66, 41.6 306.56, 98.21 -112.1, 49.9 out-none out 12.547 Saltbr-none 999.0 HRD-out -119.24, 148.11 -82.73, -152.25 none-out-out SNCnoo out-out ActLoopNT-out 5.54 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -49.7 APE8-rot-out 174.63 APE67-dihe-in -50.05, -30.9 -49.27, -45.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.96 0.187 0.228 A 272 250 12 0 0 12 [[133, 383]] 1.0 6c2r CAMK_AURKA_HUMAN CAMK 6.6e-80 274.1 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6C2TA O14965 128 388 403.0 EGJ:401 Type1 Inactive DFGinter 5.758 8.607 None DFGAsp-rot-out -125.5, 12.46 -90.2, -9.56 54.49, 19.72 59.46, 21.11 281.41, 42.78 -76.77, 51.45 out-out out 12.138 Saltbr-out 8.221 HRD-out -119.45, 155.85 -86.58, -149.59 out-out-out SNCooo out-out ActLoopNT-out 5.412 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -68.15, 136.69 APE9-dihe-na 71.69, 6.8 APE8-dihe-out -94.33, -26.09 APE8-rot-out 197.45 APE67-dihe-in -52.44, -25.84 -48.85, -45.94 APE12-dist-out 23.122 APE11-dist-out 26.722 APE10-dist-out 30.388 APE9-dist-out 34.839 None None None XRAY 1.73 0.185 0.22 A 272 253 8 0 0 8 [[133, 383]] 1.0 6c2t CAMK_AURKA_HUMAN CAMK 6.6e-80 274.1 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3W16A O14965 126 388 403.0 P9J:501 Type1 Inactive DFGinter 8.419 7.071 None DFGAsp-rot-out -121.69, 15.12 -95.95, 166.06 63.56, 6.47 -111.07, 78.29 312.23, 83.01 -146.87, 73.18 out-out out 12.343 Saltbr-out 10.328 HRD-out -113.79, 141.39 -72.7, -138.65 out-out-out SNCooo out-out ActLoopNT-out 5.395 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 65.19 APE8-dihe-in -37.14, 90.48 APE8-rot-out 235.25 APE67-dihe-out -39.45, -35.35 47.17, -54.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.494 None None None XRAY 2.8 0.235 0.322 A 278 249 14 0 0 11 [[133, 383]] 1.0 3w16 CAMK_AURKA_HUMAN CAMK 7.2e-80 274.0 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2J50A O14965 128 389 403.0 627:1390 Type1 Inactive DFGinter 9.246 7.02 None DFGAsp-rot-out -113.57, -10.87 -64.28, 174.0 56.39, 47.45 -114.87, 30.19 305.8, 146.38 -88.31, 66.84 out-out out 12.509 Saltbr-out 9.294 HRD-out -123.95, 152.65 -81.99, -145.81 out-out-out SNCooo out-out ActLoopNT-out 5.444 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -105.31, 129.43 APE9-dihe-na 72.62, 27.27 APE8-dihe-out -102.11, -34.98 APE8-rot-in 309.79 APE67-dihe-in -58.95, -17.94 -50.8, -43.26 APE12-dist-out 19.566 APE11-dist-out 16.656 APE10-dist-out 20.802 APE9-dist-out 14.696 None None None XRAY 3.0 0.221 0.268 A 280 250 12 0 0 8 [[133, 383]] 1.0 2j50 CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2J50B O14965 128 389 403.0 627:1390 Type1 Inactive DFGinter 9.246 7.02 None DFGAsp-rot-out -113.53, -10.86 -64.28, 174.02 56.39, 47.48 -114.89, 30.13 305.81, 146.41 -88.25, 66.85 out-out out 12.51 Saltbr-out 9.294 HRD-out -123.96, 152.62 -82.01, -145.78 out-out-out SNCooo out-out ActLoopNT-out 5.445 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -105.31, 129.37 APE9-dihe-na 72.63, 27.29 APE8-dihe-out -102.14, -34.97 APE8-rot-in 309.77 APE67-dihe-in -58.91, -17.97 -50.79, -43.31 APE12-dist-out 19.566 APE11-dist-out 16.656 APE10-dist-out 20.802 APE9-dist-out 14.696 None None None XRAY 3.0 0.221 0.268 B 280 250 12 0 0 8 [[133, 383]] 1.0 2j50 CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4ZTRA O14965 127 388 403.0 4RJ:501 Type1 Inactive DFGinter 8.997 8.674 None DFGAsp-rot-out -145.71, 65.97 -113.49, 176.73 62.18, -43.27 -135.74, 26.63 211.29, 77.47 -104.42, 142.78 out-out out 13.073 Saltbr-out 9.502 HRD-out 62.28, 87.69 -105.24, 141.97 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -99.17 APE8-dihe-in -82.2, 138.42 APE8-rot-out 194.18 APE67-dihe-in -47.8, -30.35 -87.76, -14.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.49 None None None XRAY 2.85 0.215 0.268 A 285 249 13 0 0 13 [[133, 383]] 1.0 4ztr CAMK_AURKA_HUMAN CAMK 7.9e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6Z4YA O14965 124 389 403.0 Q7Q:508 Type1 Inactive DFGinter 5.793 8.485 None DFGAsp-rot-in -99.87, -29.52 -56.3, 117.27 187.13, 14.03 -64.91, 155.66 280.74, 8.23 -48.06, 135.67 out-out out 12.261 Saltbr-out 8.724 HRD-out -130.04, 168.56 -116.49, -65.11 out-out-out SNCooo out-out ActLoopNT-out 8.298 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 118.23 APE9-dihe-na -146.9, 152.55 APE8-dihe-in -65.96, 130.4 APE8-rot-in 311.48 APE67-dihe-in -49.06, -39.99 -82.96, -11.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.175 APE9-dist-out 11.101 None None None XRAY 2.25 0.209 0.257 A 285 259 7 0 0 7 [[133, 383]] 1.0 6z4y CAMK_AURKA_HUMAN CAMK 7.9e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6CPGA O14965 127 387 403.0 35R:501 Type1 Inactive DFGinter 6.711 9.485 None DFGAsp-rot-out -140.02, 96.03 -108.44, 103.16 309.86, -31.7 -141.15, -67.9 302.74, 112.44 175.19, -125.6 out-out out 12.429 Saltbr-out 10.941 HRD-out 55.39, 71.59 -104.21, 123.45 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, -80.02 APE9-dihe-na 97.77, -146.55 APE8-dihe-out -62.97, -12.48 APE8-rot-none 999.0 APE67-dihe-in -58.41, -29.26 -54.85, -41.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.041 APE9-dist-out 13.657 None None None XRAY 2.8 0.285 0.335 A 285 249 12 0 0 12 [[133, 383]] 1.0 6cpg CAMK_AURKA_HUMAN CAMK 7.9e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6CPGD O14965 127 388 403.0 35R:501 Type1 Inactive DFGinter 6.404 9.772 None DFGAsp-rot-in -125.89, 77.36 -98.94, 84.58 188.96, -30.01 -127.68, 52.17 302.92, 103.94 97.64, -149.27 out-out out 11.62 Saltbr-out 12.775 HRD-out 61.84, 98.64 -116.43, 122.15 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nooo APE10-dihe-na -115.97, 178.85 APE9-dihe-na -115.52, -132.49 APE8-dihe-out -76.59, 1.28 APE8-rot-out 68.27 APE67-dihe-in -65.85, -12.72 -75.15, -27.74 APE12-dist-none 999.0 APE11-dist-out 19.388 APE10-dist-out 16.46 APE9-dist-out 14.83 None None None XRAY 2.8 0.285 0.335 D 285 252 10 0 0 10 [[133, 383]] 1.0 6cpg CAMK_AURKA_HUMAN CAMK 7.9e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8SSOA O14965 127 389 403.0 627:503 Type1 Inactive DFGinter 5.399 10.215 None DFGAsp-rot-out -108.08, -33.36 50.1, -154.98 296.02, -53.91 50.19, 34.56 301.31, 89.86 -57.19, -31.19 out-out out 12.334 Saltbr-out 8.618 HRD-out 58.03, 59.93 -81.1, 151.47 out-out-out SNCooo out-out ActLoopNT-out 16.603 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na -77.17, 142.4 APE9-dihe-na -91.52, -9.13 APE8-dihe-out -58.73, -51.63 APE8-rot-in 325.37 APE67-dihe-in -60.47, -22.49 -51.35, -46.12 APE12-dist-none 999.0 APE11-dist-out 14.244 APE10-dist-out 9.697 APE9-dist-out 11.744 None None None XRAY 1.97 0.194 0.234 A 285 256 7 0 0 7 [[133, 383]] 1.0 8sso CAMK_AURKA_HUMAN CAMK 7.9e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8SSOD O14965 127 389 403.0 627:501 Type1 Inactive DFGinter 5.281 10.122 None DFGAsp-rot-out -105.7, -31.6 53.01, -156.16 294.94, -80.8 52.08, 37.65 306.05, 89.37 -57.92, -31.1 out-out out 12.291 Saltbr-out 8.476 HRD-out 56.18, 68.26 -87.55, 151.34 out-out-none SNCoon out-none ActLoopNT-out 16.733 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -51.48 APE8-rot-in 286.23 APE67-dihe-in -64.32, -21.7 -60.98, -32.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.97 0.194 0.234 D 285 252 11 0 0 11 [[133, 383]] 1.0 8sso CAMK_AURKA_HUMAN CAMK 7.9e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 1MUOA O14965 128 388 403.0 ADN:1 Type1 Inactive DFGinter 5.924 9.006 None DFGAsp-rot-out -137.2, 91.65 -102.67, 104.14 293.73, -7.27 -141.95, -158.0 317.38, 80.93 -72.97, -80.68 out-out out 11.315 Saltbr-out 7.859 HRD-out -71.01, -147.46 164.07, -11.44 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na -39.4, -7.29 APE9-dihe-na -9.41, -37.67 APE8-dihe-out -44.74, -65.33 APE8-rot-in 311.2 APE67-dihe-in -15.91, -41.07 -76.59, -51.98 APE12-dist-none 999.0 APE11-dist-out 18.196 APE10-dist-out 19.849 APE9-dist-out 11.811 None None None XRAY 2.9 0.26 0.29 A 297 251 10 0 0 10 [[133, 383]] 1.0 1muo CAMK_AURKA_HUMAN CAMK 9.2e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2J4ZA O14965 126 389 403.0 626:1389 Type1 Inactive DFGinter 6.627 9.716 None DFGAsp-rot-out -134.66, 62.98 -108.04, 40.82 76.5, -58.27 -66.1, -23.24 173.81, 60.57 87.3, -158.48 out-out out 12.436 Saltbr-out 8.057 HRD-out 53.27, 78.66 -109.39, 156.45 out-out-out SNCooo out-out ActLoopNT-out 18.635 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -90.61, -7.12 APE9-dihe-na 129.6, -174.7 APE8-dihe-in -67.83, 122.81 APE8-rot-in 307.59 APE67-dihe-in -55.64, -29.26 -49.16, -49.7 APE12-dist-out 15.534 APE11-dist-in 13.84 APE10-dist-out 16.374 APE9-dist-out 7.615 None None None XRAY 2.0 0.214 0.249 A 306 264 0 0 0 0 [[133, 383]] 1.0 2j4z CAMK_AURKA_HUMAN CAMK 1e-79 273.5 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UNZA O14965 127 389 403.0 0BZ:2 Type1 Inactive DFGinter 5.99 8.922 None DFGAsp-rot-in -84.5, -63.75 54.99, -138.14 236.44, 48.66 56.38, -121.0 215.05, 157.51 -49.6, 129.64 out-out out 11.635 Saltbr-out 8.507 HRD-out 65.37, 47.67 -71.53, 145.54 out-out-out SNCooo out-out ActLoopNT-out 17.162 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 99.65, -2.93 APE9-dihe-na -89.71, 20.26 APE8-dihe-out -80.64, -73.77 APE8-rot-out 51.18 APE67-dihe-in -55.59, -35.44 -82.63, -1.22 APE12-dist-out 14.553 APE11-dist-in 10.839 APE10-dist-out 15.946 APE9-dist-out 14.046 T287D None None XRAY 2.8 0.231 0.278 A 279 263 0 0 0 0 [[133, 383]] 1.0 3unz CAMK_AURKA_HUMAN CAMK 8.9e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UNZB O14965 127 389 403.0 0BZ:1 Type1 Inactive DFGinter 5.985 8.919 None DFGAsp-rot-in -84.43, -63.71 55.14, -138.06 236.61, 48.53 56.46, -120.92 215.0, 157.19 -49.66, 129.46 out-out out 11.64 Saltbr-out 8.5 HRD-out 65.25, 47.84 -72.14, 146.01 out-out-out SNCooo out-out ActLoopNT-out 17.154 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 99.26, -2.89 APE9-dihe-na -90.04, 20.41 APE8-dihe-out -81.04, -73.69 APE8-rot-out 50.59 APE67-dihe-in -55.45, -35.38 -82.74, -1.38 APE12-dist-out 14.561 APE11-dist-in 10.842 APE10-dist-out 15.95 APE9-dist-out 14.036 T287D None None XRAY 2.8 0.231 0.278 B 279 263 0 0 0 0 [[133, 383]] 1.0 3unz CAMK_AURKA_HUMAN CAMK 8.9e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UO6A O14965 126 389 403.0 0BY:1 Type1 Inactive DFGinter 6.089 8.947 None DFGAsp-rot-in -92.08, -63.22 55.79, -136.4 223.59, 46.24 58.35, -117.73 204.46, 160.17 -58.84, 166.86 out-out out 11.303 Saltbr-out 11.422 HRD-out 44.35, 72.76 -98.46, 135.56 out-out-out SNCooo out-out ActLoopNT-out 17.227 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 76.96, -17.98 APE9-dihe-na -113.29, 10.31 APE8-dihe-out -74.35, -72.68 APE8-rot-out 36.75 APE67-dihe-in -49.94, -38.95 -75.25, -15.59 APE12-dist-out 14.642 APE11-dist-in 12.205 APE10-dist-out 16.592 APE9-dist-out 14.163 T287D None None XRAY 2.8 0.229 0.276 A 279 264 0 0 0 0 [[133, 383]] 1.0 3uo6 CAMK_AURKA_HUMAN CAMK 8.9e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UO6B O14965 126 389 403.0 0BY:2 Type1 Inactive DFGinter 6.088 8.935 None DFGAsp-rot-in -92.34, -63.27 55.7, -136.72 223.56, 47.34 58.91, -118.35 204.74, 161.14 -58.96, 166.79 out-out out 11.272 Saltbr-out 11.476 HRD-out 44.24, 73.02 -98.37, 136.49 out-out-out SNCooo out-out ActLoopNT-out 17.232 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 75.5, -18.28 APE9-dihe-na -114.49, 10.92 APE8-dihe-out -74.12, -73.35 APE8-rot-out 38.72 APE67-dihe-in -50.19, -38.98 -73.97, -15.63 APE12-dist-out 14.652 APE11-dist-in 12.209 APE10-dist-out 16.593 APE9-dist-out 14.154 T287D None None XRAY 2.8 0.229 0.276 B 279 264 0 0 0 0 [[133, 383]] 1.0 3uo6 CAMK_AURKA_HUMAN CAMK 8.9e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UOHA O14965 126 389 403.0 0C4:2 Type1 Inactive DFGinter 6.038 8.914 None DFGAsp-rot-in -93.18, -63.37 54.89, -130.23 203.15, 49.69 58.47, -116.07 202.5, 1.54 -59.86, 169.88 out-out out 12.203 Saltbr-out 10.642 HRD-out 60.57, 51.18 -70.61, 154.26 out-out-out SNCooo out-out ActLoopNT-out 17.297 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 97.37, -1.48 APE9-dihe-na -94.0, 16.64 APE8-dihe-out -73.09, -72.62 APE8-rot-out 34.55 APE67-dihe-in -54.13, -35.68 -91.14, -1.84 APE12-dist-out 14.349 APE11-dist-in 11.496 APE10-dist-out 16.559 APE9-dist-out 14.003 T287D None None XRAY 2.8 0.23 0.288 A 279 264 0 0 0 0 [[133, 383]] 1.0 3uoh CAMK_AURKA_HUMAN CAMK 8.9e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UOHB O14965 126 389 403.0 0C4:1 Type1 Inactive DFGinter 6.035 8.9 None DFGAsp-rot-in -93.16, -63.34 54.68, -130.86 203.8, 50.91 58.94, -116.29 202.73, 0.89 -60.04, 170.49 out-out out 12.252 Saltbr-out 10.459 HRD-out 56.43, 52.93 -71.71, 154.95 out-out-out SNCooo out-out ActLoopNT-out 17.286 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 97.52, -1.59 APE9-dihe-na -93.94, 16.64 APE8-dihe-out -72.82, -72.33 APE8-rot-out 34.94 APE67-dihe-in -54.2, -36.03 -91.21, -1.67 APE12-dist-out 14.353 APE11-dist-in 11.507 APE10-dist-out 16.576 APE9-dist-out 14.01 T287D None None XRAY 2.8 0.23 0.288 B 279 264 0 0 0 0 [[133, 383]] 1.0 3uoh CAMK_AURKA_HUMAN CAMK 8.9e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UOJA O14965 127 389 403.0 0C5:1 Type1 Inactive DFGinter 6.25 8.652 None DFGAsp-rot-in -89.03, -64.22 49.6, -140.48 202.36, 83.05 55.65, -113.8 181.43, 6.66 -48.52, 138.84 out-out out 12.901 Saltbr-out 10.167 HRD-out 77.34, -11.89 -40.57, 125.77 out-out-out SNCooo out-out ActLoopNT-out 16.765 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 98.97, 1.26 APE9-dihe-na -102.25, -2.44 APE8-dihe-out -61.85, -58.87 APE8-rot-out 33.31 APE67-dihe-in -56.59, -30.78 -67.25, -33.49 APE12-dist-out 15.388 APE11-dist-in 12.589 APE10-dist-out 17.417 APE9-dist-out 14.292 T287D None None XRAY 2.9 0.227 0.274 A 279 263 0 0 0 0 [[133, 383]] 1.0 3uoj CAMK_AURKA_HUMAN CAMK 8.9e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UOJB O14965 127 389 403.0 0C5:2 Type1 Inactive DFGinter 6.264 8.645 None DFGAsp-rot-in -88.87, -64.57 49.7, -140.5 202.15, 83.09 55.59, -113.73 181.06, 6.55 -48.5, 138.54 out-out out 12.909 Saltbr-out 10.148 HRD-out 77.24, -11.84 -40.35, 125.95 out-out-out SNCooo out-out ActLoopNT-out 16.76 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 98.86, 1.29 APE9-dihe-na -101.95, -2.75 APE8-dihe-out -62.17, -58.93 APE8-rot-out 33.01 APE67-dihe-in -57.8, -30.14 -66.39, -33.04 APE12-dist-out 15.387 APE11-dist-in 12.586 APE10-dist-out 17.416 APE9-dist-out 14.289 T287D None None XRAY 2.9 0.227 0.274 B 279 263 0 0 0 0 [[133, 383]] 1.0 3uoj CAMK_AURKA_HUMAN CAMK 8.9e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UOKA O14965 125 389 403.0 0C6:2 Type1 Inactive DFGinter 5.75 9.284 None DFGAsp-rot-in -87.48, -71.36 58.97, -135.37 194.51, 66.3 54.65, -117.02 195.51, 34.07 -55.93, 122.72 out-out out 11.898 Saltbr-out 12.916 HRD-out 40.64, 72.07 -97.16, 132.51 out-out-out SNCooo out-out ActLoopNT-out 17.098 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 75.79, -21.51 APE9-dihe-na -114.86, 8.46 APE8-dihe-out -81.91, -68.59 APE8-rot-out 58.99 APE67-dihe-in -48.81, -38.43 -66.52, -22.51 APE12-dist-out 14.101 APE11-dist-in 12.292 APE10-dist-out 16.966 APE9-dist-out 14.859 T287D None None XRAY 2.951 0.223 0.276 A 279 265 0 0 0 0 [[133, 383]] 1.0 3uok CAMK_AURKA_HUMAN CAMK 8.9e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UOKB O14965 125 389 403.0 0C6:1 Type1 Inactive DFGinter 5.749 9.277 None DFGAsp-rot-in -88.85, -71.53 59.08, -134.89 194.8, 66.69 54.38, -116.99 195.48, 34.01 -56.06, 122.86 out-out out 11.877 Saltbr-out 12.919 HRD-out 40.28, 71.92 -97.4, 131.84 out-out-out SNCooo out-out ActLoopNT-out 17.078 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 75.7, -21.55 APE9-dihe-na -114.97, 8.84 APE8-dihe-out -82.0, -69.27 APE8-rot-out 58.99 APE67-dihe-in -49.23, -38.63 -66.58, -21.59 APE12-dist-out 14.096 APE11-dist-in 12.283 APE10-dist-out 16.963 APE9-dist-out 14.861 T287D None None XRAY 2.951 0.223 0.276 B 279 265 0 0 0 0 [[133, 383]] 1.0 3uok CAMK_AURKA_HUMAN CAMK 8.9e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UOLA O14965 127 389 403.0 0C7:2 Type1 Inactive DFGinter 6.069 8.657 None DFGAsp-rot-in -80.65, -49.91 38.66, -132.1 197.67, 72.36 60.59, -110.72 197.86, 22.76 -76.74, 23.35 out-out out 13.78 Saltbr-out 9.949 HRD-out 53.65, 45.58 -63.49, 138.74 out-out-out SNCooo out-out ActLoopNT-out 17.096 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 91.11, -3.8 APE9-dihe-na -96.74, -20.87 APE8-dihe-out -56.71, -68.79 APE8-rot-out 61.79 APE67-dihe-in -54.04, -24.57 -47.13, -38.35 APE12-dist-out 15.112 APE11-dist-in 13.784 APE10-dist-out 17.724 APE9-dist-out 14.403 T287D None None XRAY 2.4 0.237 0.283 A 279 263 0 0 0 0 [[133, 383]] 1.0 3uol CAMK_AURKA_HUMAN CAMK 8.9e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UOLB O14965 127 389 403.0 0C7:1 Type1 Inactive DFGinter 5.99 8.66 None DFGAsp-rot-in -80.74, -49.45 38.08, -131.75 197.55, 72.37 60.44, -110.58 198.19, 22.88 -77.08, 23.2 out-out out 13.776 Saltbr-out 9.959 HRD-out 54.22, 44.36 -62.05, 139.57 out-out-out SNCooo out-out ActLoopNT-out 17.093 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 91.25, -3.95 APE9-dihe-na -95.92, -22.22 APE8-dihe-out -56.1, -68.18 APE8-rot-out 62.15 APE67-dihe-in -54.2, -24.78 -47.47, -38.07 APE12-dist-out 15.123 APE11-dist-in 13.791 APE10-dist-out 17.732 APE9-dist-out 14.391 T287D None None XRAY 2.4 0.237 0.283 B 279 263 0 0 0 0 [[133, 383]] 1.0 3uol CAMK_AURKA_HUMAN CAMK 8.9e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3FDNA O14965 126 394 403.0 MMH:1 Type1 Inactive DFGinter 5.835 8.7 None DFGAsp-rot-out -113.83, -12.3 -83.93, 150.0 88.19, 12.07 -89.96, 27.39 288.28, 8.62 -77.57, 62.14 out-out out 12.168 Saltbr-out 8.347 HRD-out -96.45, 141.44 -71.53, -154.43 out-out-out SNCooo out-out ActLoopNT-out 5.673 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -102.73 APE9-dihe-na 114.27, 146.94 APE8-dihe-in -67.7, 139.44 APE8-rot-in 273.96 APE67-dihe-in -48.36, -34.0 -88.05, -6.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.575 APE9-dist-out 13.34 T288D None None XRAY 1.9 0.231 0.287 A 279 261 8 0 0 8 [[133, 383]] 1.0 3fdn CAMK_AURKA_HUMAN CAMK 1.7e-79 272.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3K5UA O14965 126 394 403.0 PFQ:1001 Type1 Inactive DFGinter 5.707 8.825 None DFGAsp-rot-out -107.52, -18.97 -91.45, 151.1 58.95, -11.53 -94.09, 23.54 298.73, 177.78 -72.02, 54.86 out-out out 12.124 Saltbr-out 8.719 HRD-out -88.39, 148.19 -76.48, -155.88 out-out-out SNCooo out-out ActLoopNT-out 5.365 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -121.1 APE9-dihe-na 103.03, 152.44 APE8-dihe-in -66.2, 143.09 APE8-rot-in 275.11 APE67-dihe-in -49.38, -31.53 -92.54, -7.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.461 APE9-dist-out 13.435 T288D None None XRAY 2.35 0.242 0.26 A 279 260 9 0 0 9 [[133, 383]] 1.0 3k5u CAMK_AURKA_HUMAN CAMK 1.7e-79 272.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4JBQA O14965 126 391 403.0 VX6:501 Type1 Inactive DFGinter 5.863 8.977 None DFGAsp-rot-out -117.17, -3.86 -81.51, -172.59 53.23, 32.28 -125.34, 20.35 277.47, 29.16 -74.78, 56.29 out-out out 12.325 Saltbr-out 9.46 HRD-out -106.24, 150.32 -82.52, -162.88 out-out-out SNCooo out-out ActLoopNT-out 5.42 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 124.19 APE9-dihe-na 110.15, 136.99 APE8-dihe-in -65.42, 141.32 APE8-rot-out 182.94 APE67-dihe-in -48.15, -34.26 -90.56, -13.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 16.718 APE9-dist-out 13.313 T288D None None XRAY 2.3 0.227 0.282 A 279 257 9 0 0 9 [[133, 383]] 1.0 4jbq CAMK_AURKA_HUMAN CAMK 1.7e-79 272.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3LAUA O14965 125 391 403.0 OFI:60001 Type1 Inactive DFGinter 4.874 9.47 None DFGAsp-rot-out -122.68, 72.55 -135.5, 105.71 75.7, -65.12 -124.13, 999.0 233.96, 104.58 999.0, 999.0 out-out out 11.612 Saltbr-out 10.851 HRD-out 60.88, 64.76 -92.19, 140.49 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.81, -17.37 999.0, -42.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T288D None None XRAY 2.1 0.203 0.248 A 287 250 17 0 0 17 [[133, 383]] 1.0 3lau CAMK_AURKA_HUMAN CAMK 1.9e-79 272.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4UZHA O14965 125 392 403.0 JVE:61392 Type1 Inactive DFGinter 6.165 8.847 None DFGAsp-rot-out -134.4, 63.5 -102.61, 61.53 61.13, -47.74 -163.5, 999.0 153.81, 66.79 999.0, 999.0 out-out out 11.616 Saltbr-out 7.197 HRD-out 56.64, 70.94 -95.92, 131.49 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.98, -11.66 999.0, -76.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.205 0.235 A 287 251 17 0 0 17 [[133, 383]] 1.0 4uzh CAMK_AURKA_HUMAN CAMK 1.9e-79 272.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3H0YA O14965 126 388 403.0 48B:1 Type1 Inactive DFGinter 6.252 8.418 None DFGAsp-rot-out -109.47, -26.38 -75.33, 137.27 57.05, 77.95 -77.12, 162.45 293.82, 171.84 -85.27, 155.38 out-out out 11.756 Saltbr-out 8.407 HRD-out -128.83, 133.48 -56.66, -46.86 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 129.6 APE8-rot-out 181.19 APE67-dihe-in -47.87, -33.3 -84.26, -9.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K124A,T287A,T288A None None XRAY 2.5 0.216 0.285 A 268 250 13 0 0 13 [[133, 383]] 1.0 3h0y CAMK_AURKA_HUMAN CAMK 4e-79 271.5 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3H10A O14965 124 391 403.0 97B:1 Type1 Inactive DFGinter 5.949 9.292 None DFGAsp-rot-out -85.74, 156.36 -96.9, 153.5 319.92, -30.19 66.79, 45.29 317.78, 104.47 -57.91, -32.92 out-out out 11.685 Saltbr-out 10.318 HRD-out 59.2, 41.52 -65.77, 140.34 out-out-out SNCooo out-out ActLoopNT-out 17.434 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -128.56, 51.89 APE9-dihe-na 117.04, -170.29 APE8-dihe-in -90.19, 120.52 APE8-rot-in 294.83 APE67-dihe-in -57.04, -32.9 -46.43, -51.7 APE12-dist-in 10.276 APE11-dist-out 14.601 APE10-dist-out 13.537 APE9-dist-out 10.476 K124A,T287A,T288A None None XRAY 2.2 0.197 0.24 A 268 268 0 0 0 0 [[133, 383]] 1.0 3h10 CAMK_AURKA_HUMAN CAMK 4e-79 271.5 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3H10B O14965 125 391 403.0 97B:2 Type1 Inactive DFGinter 6.086 9.1 None DFGAsp-rot-out -84.1, 155.64 -96.32, 147.85 310.3, -36.72 67.68, 47.0 313.1, 101.31 -64.96, -29.8 out-out out 11.348 Saltbr-out 9.737 HRD-out 52.62, 55.73 -75.29, 145.84 out-out-out SNCooo out-out ActLoopNT-out 17.595 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -164.73, 70.51 APE9-dihe-na 110.59, 173.85 APE8-dihe-in -85.08, 117.86 APE8-rot-in 292.57 APE67-dihe-in -65.77, -24.94 -40.25, -55.5 APE12-dist-in 10.377 APE11-dist-out 14.491 APE10-dist-out 13.091 APE9-dist-out 10.674 K124A,T287A,T288A None None XRAY 2.2 0.197 0.24 B 268 267 0 0 0 0 [[133, 383]] 1.0 3h10 CAMK_AURKA_HUMAN CAMK 4e-79 271.5 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3H10D O14965 126 388 403.0 97B:3 Type1 Inactive DFGinter 5.652 9.351 None DFGAsp-rot-out -78.35, 156.2 -102.03, 146.36 308.32, -33.16 61.53, 46.31 320.5, 110.27 -53.35, -35.87 out-out out 12.271 Saltbr-out 10.405 HRD-out 47.1, 36.06 -65.28, 120.88 out-out-none SNCoon out-none ActLoopNT-out 16.933 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 130.75 APE8-rot-in 285.65 APE67-dihe-in -49.42, -30.99 -50.38, -44.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K124A,T287A,T288A None None XRAY 2.2 0.197 0.24 D 268 255 8 0 0 8 [[133, 383]] 1.0 3h10 CAMK_AURKA_HUMAN CAMK 4e-79 271.5 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3P9JA O14965 126 388 403.0 P9J:1 Type1 Inactive DFGinter 6.884 7.941 None DFGAsp-rot-out -102.4, -6.03 -81.85, 156.26 82.32, -23.03 -90.38, 17.14 289.53, 9.94 -77.54, 34.79 out-out out 12.372 Saltbr-out 9.879 HRD-out -106.04, 150.63 -81.01, -161.23 out-out-out SNCooo out-out ActLoopNT-out 5.35 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 98.73 APE8-dihe-in -129.65, 90.21 APE8-rot-out 170.24 APE67-dihe-in -44.1, -38.87 -140.2, 19.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.103 T287A,T288A None None XRAY 2.8 0.204 0.271 A 268 249 14 0 0 11 [[133, 383]] 1.0 3p9j CAMK_AURKA_HUMAN CAMK 4e-79 271.5 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3W10A O14965 126 388 403.0 RO9:501 Type1 Inactive DFGinter 6.373 9.695 None DFGAsp-rot-out -119.04, 54.38 -98.61, 30.05 66.47, -31.36 -138.73, 164.74 58.12, 85.11 47.87, 16.56 out-out out 11.801 Saltbr-out 10.333 HRD-out 62.97, 65.74 -95.42, 130.99 out-out-out SNCooo out-out ActLoopNT-out 17.48 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -81.52, 14.87 APE9-dihe-na -42.97, -40.22 APE8-dihe-out -121.83, 17.25 APE8-rot-out 76.19 APE67-dihe-in -68.64, -18.29 -61.37, -40.89 APE12-dist-in 9.752 APE11-dist-out 14.714 APE10-dist-out 16.055 APE9-dist-out 11.775 T287A,T288A None None XRAY 2.7 0.249 0.309 A 278 263 0 0 0 0 [[133, 383]] 1.0 3w10 CAMK_AURKA_HUMAN CAMK 4.6e-79 271.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3R22A O14965 126 389 403.0 D37:1 Type1 Inactive DFGinter 6.472 8.557 None DFGAsp-rot-in -142.77, -34.51 -91.78, -141.21 229.55, 36.12 -154.74, 60.2 276.78, 88.9 -152.2, 21.14 out-out out 11.924 Saltbr-out 7.894 HRD-out -77.07, 147.44 -101.45, -61.81 out-out-out SNCooo out-out ActLoopNT-out 4.786 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 163.54 APE8-dihe-in -57.16, 146.3 APE8-rot-out 184.12 APE67-dihe-in -47.8, -31.62 -95.89, 1.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.996 T287D,T288D None None XRAY 2.9 0.271 0.313 A 271 255 9 0 0 9 [[133, 383]] 1.0 3r22 CAMK_AURKA_HUMAN CAMK 1.8e-79 272.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 9KDSA O14965 126 391 403.0 A1EFT:220 Type1 Inactive DFGinter 5.841 9.061 None DFGAsp-rot-out -115.36, -22.96 -73.25, 150.65 63.32, 66.51 -96.11, 14.3 285.47, 2.42 -64.22, 74.88 out-out out 12.262 Saltbr-out 9.104 HRD-out -98.78, 149.89 -79.07, -155.21 out-out-out SNCooo out-out ActLoopNT-out 5.2 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -139.65 APE8-dihe-in -67.03, 136.06 APE8-rot-in 265.66 APE67-dihe-in -47.15, -28.7 -90.01, -5.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.643 C290A None A1EFT220 XRAY 2.5 0.217 0.253 A 266 257 9 0 0 9 [[133, 383]] 1.0 9kds CAMK_AURKA_HUMAN CAMK 1e-78 270.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2BMCA O14965 127 394 403.0 MPY:1395 Type1 Inactive DFGinter 6.581 8.649 None DFGAsp-rot-out -120.22, 2.69 -79.74, 177.87 50.0, 44.14 -120.44, 28.65 279.36, 74.44 -63.39, 54.99 out-out out 12.712 Saltbr-out 9.648 HRD-out -124.67, 146.35 -86.18, -146.55 out-out-out SNCooo out-out ActLoopNT-out 5.399 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -132.56 APE8-rot-out 47.16 APE67-dihe-in -49.36, -30.39 -47.35, -35.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.228 0.252 A 306 256 12 0 0 12 [[133, 383]] 1.0 2bmc CAMK_AURKA_HUMAN CAMK 2.9e-79 272.0 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2BMCB O14965 125 394 403.0 MPY:1395 Type1 Inactive DFGinter 6.807 8.53 None DFGAsp-rot-out -121.32, 0.27 -78.21, 179.92 51.44, 40.1 -122.08, 26.9 281.74, 72.08 -64.82, 57.86 out-out out 12.742 Saltbr-out 9.349 HRD-out -129.07, 147.12 -89.63, -143.13 out-out-out SNCooo out-out ActLoopNT-out 5.335 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -148.66 APE8-rot-out 47.86 APE67-dihe-in -45.98, -40.8 -48.24, -32.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.228 0.252 B 306 258 12 0 0 12 [[133, 383]] 1.0 2bmc CAMK_AURKA_HUMAN CAMK 2.9e-79 272.0 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2BMCC O14965 125 393 403.0 MPY:1394 Type1 Inactive DFGinter 6.84 8.563 None DFGAsp-rot-out -111.71, -8.17 -78.0, 176.81 56.83, 39.87 -119.82, 27.04 283.62, 65.51 -62.65, 57.16 out-out out 12.759 Saltbr-out 9.29 HRD-out -129.54, 151.84 -86.76, -144.72 out-out-out SNCooo out-out ActLoopNT-out 5.453 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -175.11 APE8-rot-out 45.5 APE67-dihe-in -27.05, -38.79 -54.18, -36.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.228 0.252 C 306 257 12 0 0 12 [[133, 383]] 1.0 2bmc CAMK_AURKA_HUMAN CAMK 2.9e-79 272.0 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2BMCD O14965 127 394 403.0 MPY:1395 Type1 Inactive DFGinter 6.797 8.666 None DFGAsp-rot-out -115.73, -0.95 -79.88, 179.36 59.43, 51.25 -120.07, 22.55 284.5, 74.5 -63.99, 59.56 out-out out 12.681 Saltbr-out 9.214 HRD-out -128.93, 150.36 -86.55, -146.18 out-out-out SNCooo out-out ActLoopNT-out 5.448 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -170.43 APE8-rot-out 54.46 APE67-dihe-in -29.4, -31.11 -37.9, -57.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.228 0.252 D 306 256 12 0 0 12 [[133, 383]] 1.0 2bmc CAMK_AURKA_HUMAN CAMK 2.9e-79 272.0 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2BMCE O14965 127 394 403.0 MPY:1395 Type1 Inactive DFGinter 6.826 8.489 None DFGAsp-rot-out -115.38, -3.61 -77.32, 179.54 58.35, 54.94 -120.22, 21.67 284.65, 76.22 -63.51, 61.05 out-out out 12.642 Saltbr-out 9.434 HRD-out -126.37, 151.8 -84.41, -148.69 out-out-out SNCooo out-out ActLoopNT-out 5.452 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -151.66 APE8-rot-out 63.51 APE67-dihe-in -26.62, -34.28 -40.09, -60.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.228 0.252 E 306 256 12 0 0 12 [[133, 383]] 1.0 2bmc CAMK_AURKA_HUMAN CAMK 2.9e-79 272.0 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2BMCF O14965 126 394 403.0 MPY:1395 Type1 Inactive DFGinter 6.508 8.822 None DFGAsp-rot-out -115.69, -5.93 -78.56, 177.32 60.24, 37.71 -122.14, 28.38 282.23, 67.06 -65.82, 60.75 out-out out 12.753 Saltbr-out 9.271 HRD-out -127.86, 148.46 -84.63, -148.84 out-out-out SNCooo out-out ActLoopNT-out 5.413 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -159.21 APE8-rot-out 48.76 APE67-dihe-in -12.19, -42.56 -50.87, -58.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.228 0.252 F 306 257 12 0 0 12 [[133, 383]] 1.0 2bmc CAMK_AURKA_HUMAN CAMK 2.9e-79 272.0 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 7FICA O14965 127 391 403.0 5YZ:401 Type1 Inactive DFGinter 6.656 8.698 None DFGAsp-rot-in -127.87, 74.52 -84.56, 58.76 202.82, 3.75 -143.59, 98.4 223.5, 108.01 121.48, 144.52 out-none out 11.431 Saltbr-none 999.0 HRD-out -142.2, 146.4 -144.31, 136.82 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 142.56 APE9-dihe-na -122.69, 31.13 APE8-dihe-out -54.83, -47.63 APE8-rot-out 52.3 APE67-dihe-in -64.7, -30.85 -67.62, -21.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.168 APE9-dist-out 15.104 C290A None None XRAY 2.32 0.237 0.274 A 265 254 11 0 0 11 [[133, 383]] 1.0 7fic CAMK_AURKA_HUMAN CAMK 7.4e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 9BZGA O14965 127 388 403.0 OG0:501 Type1 Inactive DFGinter 5.574 8.954 None DFGAsp-rot-out -138.21, 40.41 -80.38, -6.22 66.52, -44.17 -58.44, 128.99 169.82, 66.7 87.71, 11.81 out-out out 12.011 Saltbr-out 11.35 HRD-out 57.43, 61.28 -82.68, 137.68 out-out-out SNCooo out-out ActLoopNT-out 16.905 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -68.5, -47.56 APE9-dihe-na -63.47, -40.24 APE8-dihe-out -67.43, -41.81 APE8-rot-in 291.8 APE67-dihe-in -55.03, -25.33 -61.13, -40.77 APE12-dist-in 8.031 APE11-dist-in 12.176 APE10-dist-out 14.813 APE9-dist-out 11.654 C290A,C393S TPO288 TPO288 XRAY 1.8 0.188 0.22 A 285 262 0 0 0 0 [[133, 383]] 1.0 9bzg CAMK_AURKA_HUMAN CAMK 9.7e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 9BZLB O14965 127 388 403.0 OGR:501 Type1 Inactive DFGinter 5.652 8.924 None DFGAsp-rot-out -136.55, 35.09 -77.99, -4.99 60.43, -38.27 -64.56, 136.29 165.56, 68.13 84.66, 11.21 out-out out 12.145 Saltbr-out 11.508 HRD-out 58.91, 63.34 -81.19, 137.19 out-out-out SNCooo out-out ActLoopNT-out 16.842 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -64.8, -45.23 APE9-dihe-na -65.62, -37.14 APE8-dihe-out -65.61, -42.19 APE8-rot-in 287.26 APE67-dihe-in -56.13, -23.23 -60.59, -40.07 APE12-dist-in 8.118 APE11-dist-in 11.676 APE10-dist-out 14.621 APE9-dist-out 11.701 C290A,C393S TPO288 TPO288 XRAY 1.81 0.192 0.214 B 285 262 0 0 0 0 [[133, 383]] 1.0 9bzl CAMK_AURKA_HUMAN CAMK 9.7e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 9KS6A O14965 127 391 403.0 A1EG1:162 Type1 Inactive DFGinter 5.888 9.106 None DFGAsp-rot-out -147.81, 30.43 -100.08, -15.16 50.94, -31.77 61.73, 18.3 290.83, 10.75 -77.9, 72.48 out-na out 12.472 Saltbr-na 9.13 HRD-out -111.85, 134.04 -63.11, -66.03 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 127.23 APE8-rot-in 299.78 APE67-dihe-in -48.85, -29.53 -94.69, -1.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None A1EG1162 XRAY 2.75 0.232 0.267 A 265 251 14 0 0 14 [[133, 383]] 1.0 9ks6 CAMK_AURKA_HUMAN CAMK 2.6e-78 268.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4ZTQA O14965 127 388 403.0 4RM:501 Type1.5_Back Inactive DFGinter 9.794 7.55 None DFGAsp-rot-out -128.95, 86.44 -158.65, -177.96 61.36, 22.43 -107.17, 35.48 297.86, 94.26 -105.4, 22.98 out-out out 11.777 Saltbr-out 13.148 HRD-out -111.76, 156.87 -90.96, -144.93 out-out-out SNCooo out-out ActLoopNT-out 5.266 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -178.64 APE8-dihe-in -81.15, 143.47 APE8-rot-out 185.07 APE67-dihe-in -33.25, -44.07 -77.96, -26.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.941 None None None XRAY 2.8 0.203 0.246 A 285 247 15 0 0 11 [[133, 383]] 1.0 4ztq CAMK_AURKA_HUMAN CAMK 7.9e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4ZTSA O14965 127 388 403.0 4RK:501 Type1.5_Back Inactive DFGinter 9.857 7.612 None DFGAsp-rot-out -142.98, 93.02 -162.47, -179.72 59.4, 21.49 -105.27, 64.86 290.53, 116.01 159.83, 107.65 out-out out 12.238 Saltbr-out 12.539 HRD-out -124.72, 145.07 -84.3, -151.71 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 133.6 APE8-rot-out 180.3 APE67-dihe-in -43.16, -25.38 -86.65, -10.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.213 0.249 A 285 249 13 0 0 13 [[133, 383]] 1.0 4zts CAMK_AURKA_HUMAN CAMK 7.9e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3EFWA O14965 126 388 403.0 AK8:404 Type1.5_Front Inactive DFGinter 6.166 9.192 None DFGAsp-rot-in -114.69, 29.1 -93.31, 98.64 213.81, -64.46 -72.68, 999.0 277.06, 45.29 999.0, 999.0 out-none out 12.504 Saltbr-none 999.0 HRD-out -100.96, 129.93 -74.44, -133.77 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -49.97, -16.9 999.0, -48.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.29 0.26 0.295 A 267 240 23 0 0 17 [[133, 383]] 1.0 3efw CAMK_AURKA_HUMAN CAMK 6.2e-80 274.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3EFWB O14965 126 389 403.0 AK8:404 Type1.5_Front Inactive DFGinter 6.843 8.718 None DFGAsp-rot-out -97.71, -18.22 -58.8, 127.67 296.84, -65.8 -71.64, 999.0 297.41, 150.5 999.0, 999.0 out-out out 12.831 Saltbr-out 9.752 HRD-out -122.37, 142.08 -72.73, -61.12 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -56.59, -24.0 999.0, -41.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.29 0.26 0.295 B 267 242 22 0 0 17 [[133, 383]] 1.0 3efw CAMK_AURKA_HUMAN CAMK 6.2e-80 274.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3O50A O14965 126 388 403.0 LJE:1 Type1.5_Front Inactive DFGinter 6.926 8.59 None DFGAsp-rot-in -120.45, 57.47 -126.6, 83.94 204.27, -76.74 -51.28, 45.89 305.79, 65.53 -47.9, 167.61 out-out out 12.771 Saltbr-out 9.688 HRD-out -105.95, -54.24 71.67, 50.89 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.18 APE8-rot-out 177.59 APE67-dihe-in -53.46, -33.48 -54.98, -22.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.285 0.351 A 267 246 17 0 0 14 [[133, 383]] 1.0 3o50 CAMK_AURKA_HUMAN CAMK 6.2e-80 274.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3O50B O14965 126 389 403.0 LJE:1 Type1.5_Front Inactive DFGinter 7.129 8.801 None DFGAsp-rot-in -108.79, 36.5 -105.08, 99.13 215.11, 89.31 -72.4, 999.0 308.79, 175.58 999.0, 999.0 out-out out 12.868 Saltbr-out 9.636 HRD-out -123.96, 166.98 -117.96, 27.18 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -123.8, 136.42 APE9-dihe-na -70.48, -112.85 APE8-dihe-in -82.24, 115.2 APE8-rot-out 163.63 APE67-dihe-in -35.05, -31.99 -65.91, -24.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.327 None None None XRAY 2.0 0.285 0.351 B 267 249 15 0 0 11 [[133, 383]] 1.0 3o50 CAMK_AURKA_HUMAN CAMK 6.2e-80 274.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6HJJA O14965 127 393 403.0 G7T:501 Type1.5_Front Inactive DFGinter 6.251 8.493 None DFGAsp-rot-out -112.85, -19.21 -86.09, 145.25 84.13, -52.92 -81.54, -160.25 301.92, 166.71 41.76, 103.89 out-out out 12.308 Saltbr-out 9.311 HRD-out -108.67, 152.78 -84.21, -142.85 out-out-out SNCooo out-out ActLoopNT-out 5.702 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 176.9 APE8-dihe-in -60.46, 140.32 APE8-rot-out 182.81 APE67-dihe-in -42.69, -33.03 -85.17, -13.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.22 L210C,C290A,C393A None None XRAY 2.13 0.212 0.269 A 285 256 11 0 0 11 [[133, 383]] 1.0 6hjj CAMK_AURKA_HUMAN CAMK 4.3e-78 268.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKB AURKB_HUMAN 4AF3A Q96GD4 70 338 344.0 VX6:500 Type1 Inactive DFGinter 6.226 9.08 None DFGAsp-rot-none -112.4, 112.13 -127.45, 99.79 999.0, 999.0 -141.88, 168.72 285.68, 83.55 155.44, 999.0 out-out out 12.18 Saltbr-out 9.93 HRD-out -154.61, 151.72 -150.08, 147.62 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -62.83, -29.23 999.0, -55.56 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.208 0.264 A 292 253 16 0 0 16 [[77, 327]] 1.0 4af3 CAMK_AURKB_HUMAN CAMK 3.7e-80 274.9 1 256 256 217 218 219 221 223 106 125 129 197 199 198 200 255 243 238 237 236 235 234 233 232 155 Aurora kinase B
CAMK CAMK1 KCC1A_HUMAN 4FG9A Q14012 10 314 370.0 ATP:401 ATPlike Inactive DFGinter 6.372 9.923 None DFGAsp-rot-in -94.72, -48.11 -72.17, 151.42 230.85, -70.62 -111.14, 999.0 291.22, 108.3 999.0, 999.0 out-out out 13.251 Saltbr-out 11.213 HRD-in -52.69, -68.08 75.14, -19.91 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 133.2, -24.01 999.0, 22.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.211 0.249 A 320 278 27 0 0 18 [[20, 276]] 1.0 4fg9 CAMK_CAMK1_HUMAN CAMK 9.5e-97 329.5 1 256 256 161 162 163 165 167 49 66 70 138 140 139 141 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1 KCC1A_HUMAN 4FG9B Q14012 14 314 370.0 ATP:401 ATPlike Inactive DFGinter 6.287 9.324 None DFGAsp-rot-in -97.62, -42.8 -76.25, 145.4 212.44, -67.78 -105.57, 999.0 303.86, 102.8 999.0, 999.0 out-none out 16.899 Saltbr-none 999.0 HRD-in -42.26, -58.83 67.77, -17.08 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na -80.77, -34.84 APE9-dihe-na -79.39, -52.09 APE8-dihe-in -108.11, 99.06 APE8-rot-none 999.0 APE67-dihe-inflip 97.92, -38.15 -85.42, 136.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.53 None None None XRAY 2.4 0.211 0.249 B 320 279 22 0 0 10 [[20, 276]] 1.0 4fg9 CAMK_CAMK1_HUMAN CAMK 9.5e-97 329.5 1 256 256 161 162 163 165 167 49 66 70 138 140 139 141 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1 KCC1A_HUMAN 4FGBA Q14012 10 299 370.0 No_ligand No_ligand Inactive DFGinter 5.739 10.203 None DFGAsp-rot-in -104.6, -8.49 -140.3, 178.11 193.46, 14.24 -139.41, 147.23 303.38, 89.89 -87.78, 114.08 out-out out 11.588 Saltbr-out 11.141 HRD-in -53.9, -58.19 79.4, -20.41 out-out-out SNCooo out-out ActLoopNT-out 8.528 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -82.45, -17.55 APE9-dihe-na -76.06, -99.18 APE8-dihe-in -116.77, 89.48 APE8-rot-in 320.21 APE67-dihe-in -68.84, -25.9 -53.31, -20.17 APE12-dist-in 11.625 APE11-dist-out 16.719 APE10-dist-out 18.072 APE9-dist-out 11.41 None None None XRAY 2.6 0.251 0.299 A 320 282 8 0 0 0 [[20, 276]] 1.0 4fgb CAMK_CAMK1_HUMAN CAMK 9.5e-97 329.5 1 256 256 161 162 163 165 167 49 66 70 138 140 139 141 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1D KCC1D_HUMAN 6T6FA Q8IU85 12 329 385.0 MMW:60401 Type1 Inactive DFGinter 6.182 10.448 None DFGAsp-rot-in -113.61, 0.12 -149.43, 165.51 199.63, 5.92 -125.03, 154.94 303.02, 100.18 -111.73, 79.48 out-out out 12.704 Saltbr-out 10.425 HRD-in -70.96, -50.52 78.73, -1.15 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.19, -30.52 999.0, -10.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.97 0.211 0.238 A 322 289 15 0 0 15 [[23, 279]] 1.0 6t6f CAMK_CAMK1D_HUMAN CAMK 1.9e-99 338.2 1 256 256 164 165 166 168 170 52 69 73 141 143 142 144 203 191 186 185 184 183 182 181 180 99 Calcium/calmodulin-dependent protein kinase type 1D
CAMK CAMK1D KCC1D_HUMAN 6T6FB Q8IU85 12 329 385.0 MMW:60401 Type1 Inactive DFGinter 6.352 10.343 None DFGAsp-rot-in -113.49, -0.83 -150.4, 164.72 196.4, 2.02 -127.1, 154.02 307.16, 95.57 -112.6, 999.0 out-out out 12.519 Saltbr-out 10.223 HRD-in -67.18, -47.77 75.41, 3.11 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -62.9, -29.75 999.0, -9.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.97 0.211 0.238 B 322 286 17 0 0 17 [[23, 279]] 1.0 6t6f CAMK_CAMK1D_HUMAN CAMK 1.9e-99 338.2 1 256 256 164 165 166 168 170 52 69 73 141 143 142 144 203 191 186 185 184 183 182 181 180 99 Calcium/calmodulin-dependent protein kinase type 1D
CAMK CAMK1D KCC1D_HUMAN 6T29AAA Q8IU85 12 302 385.0 M8Z:410 Type1 Inactive DFGinter 6.687 10.95 None DFGAsp-rot-in -86.27, -17.21 -161.15, 144.55 188.84, 22.89 -156.05, 155.34 64.59, 91.39 -93.17, 151.07 out-out out 13.659 Saltbr-out 10.396 HRD-in -62.46, -51.48 74.27, -6.64 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -37.69 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.484 0.137 0.175 AAA 385 274 17 0 0 17 [[23, 279]] 1.0 6t29 CAMK_CAMK1D_HUMAN CAMK 3.4e-99 337.4 1 256 256 164 165 166 168 170 52 69 73 141 143 142 144 203 191 186 185 184 183 182 181 180 99 Calcium/calmodulin-dependent protein kinase type 1D
CAMK CAMK2A KCC2A_HUMAN 6W4OO Q9UQM7 7 301 478.0 No_ligand No_ligand Inactive DFGinter 10.806 10.238 None DFGAsp-rot-in -98.81, 109.81 -79.77, 114.68 178.7, 0.63 -136.99, 147.47 315.53, 123.33 104.37, -23.29 in-na in 8.798 Saltbr-na 999.0 HRD-in -73.78, -41.7 68.26, -19.24 na-in-in SNCaii in-in ActLoopNT-in 3.181 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.12, 161.52 APE9-dihe-na 103.65, -177.0 APE8-dihe-in -98.82, 133.37 APE8-rot-in 301.51 APE67-dihe-in -73.83, -31.08 -42.99, -42.18 APE12-dist-in 9.829 APE11-dist-in 10.848 APE10-dist-in 5.275 APE9-dist-in 3.989 K42M None None EM 4.8 999.0 999.0 O 473 293 2 0 0 0 [[13, 271]] 1.0 6w4o CAMK_CAMK2A_HUMAN CAMK 3.4e-93 318.2 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 6W4PH Q9UQM7 7 301 478.0 No_ligand No_ligand Inactive DFGinter 10.806 10.237 None DFGAsp-rot-in -98.91, 109.73 -79.66, 114.62 178.76, 0.59 -137.0, 147.49 315.5, 123.34 104.35, -23.19 in-na in 8.799 Saltbr-na 999.0 HRD-in -73.79, -41.59 68.22, -19.25 na-in-in SNCaii in-in ActLoopNT-in 3.181 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.15, 161.56 APE9-dihe-na 103.69, -177.07 APE8-dihe-in -98.77, 133.22 APE8-rot-in 301.62 APE67-dihe-in -73.83, -31.05 -42.85, -42.28 APE12-dist-in 9.829 APE11-dist-in 10.849 APE10-dist-in 5.276 APE9-dist-in 3.988 K42M None None EM 6.6 999.0 999.0 H 473 293 2 0 0 0 [[13, 271]] 1.0 6w4p CAMK_CAMK2A_HUMAN CAMK 3.4e-93 318.2 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 3SOAA Q9UQM7 7 474 478.0 DB8:60445 Type1 Inactive DFGinter 10.807 10.237 None DFGAsp-rot-in -98.86, 109.77 -79.7, 114.69 178.76, 0.53 -137.02, 147.48 315.53, 123.27 104.35, -23.23 in-na in 8.799 Saltbr-na 999.0 HRD-in -73.81, -41.57 68.14, -19.19 na-in-in SNCaii in-in ActLoopNT-in 3.181 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.13, 161.55 APE9-dihe-na 103.67, -177.05 APE8-dihe-in -98.78, 133.3 APE8-rot-in 301.55 APE67-dihe-in -73.82, -31.03 -42.95, -42.2 APE12-dist-in 9.829 APE11-dist-in 10.848 APE10-dist-in 5.275 APE9-dist-in 3.989 K42M,D135N,T306V None None XRAY 3.55 0.279 0.327 A 444 436 2 0 0 0 [[13, 271]] 1.0 3soa CAMK_CAMK2A_HUMAN CAMK 2.8e-93 318.5 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK MARK3 MARK3_HUMAN 9YR9B P27448 49 366 753.0 A1CZY:401 Type1 Inactive DFGinter 5.066 10.889 None DFGAsp-rot-in -108.7303, 7.4554 -91.0978, 121.7543 188.5188, 0.6861 -123.6064, 13.5626 296.6271, 91.5036 -86.8982, 110.869 out-out out 10.044 Saltbr-out 5.354 HRD-out -61.1308, 133.7274 -64.2942, -49.7121 out-out-none SNCoon out-none ActLoopNT-out 5.991 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.402 0.209 0.253 B 325 291 27 0 0 13 [[56, 307]] 1.0 9yr9 CAMK_MARK3_HUMAN CAMK 4.6e-96 327.1 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
CAMK MARK3 MARK3_HUMAN 9ZZWB P27448 49 366 753.0 A1C86:401 Type1 Inactive DFGinter 5.343 10.891 None DFGAsp-rot-in -102.9518, 5.0161 -90.5833, 103.1997 175.2656, 56.9936 -103.5954, 16.8437 297.9676, 93.0842 -88.9928, 104.8868 in-none in 9.777 Saltbr-none 999.0 HRD-out -65.103, 137.748 -63.4929, -42.9642 none-out-none SNCnon out-none ActLoopNT-out 5.904 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.76 0.259 0.286 B 325 270 48 0 0 19 [[56, 307]] 1.0 9zzw CAMK_MARK3_HUMAN CAMK 4.6e-96 327.1 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
CAMK MELK MELK_HUMAN 4IXPA Q14680 2 335 651.0 No_ligand No_ligand Inactive DFGinter 8.337 8.22 BABtrans DFGAsp-rot-none -82.53, 111.66 -97.33, 24.09 999.0, 999.0 -131.73, 132.5 172.62, 90.1 -170.06, 168.41 out-none out 11.064 Saltbr-none 999.0 HRD-in -79.62, -62.46 77.21, 0.17 none-out-out SNCnoo out-out ActLoopNT-out 8.708 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -61.36, -24.12 APE9-dihe-na -60.42, -37.63 APE8-dihe-out -71.56, -9.7 APE8-rot-in 283.03 APE67-dihe-in -61.32, -17.74 -47.81, -52.79 APE12-dist-out 6.736 APE11-dist-out 7.657 APE10-dist-out 13.168 APE9-dist-out 11.076 K40R,D150A None None XRAY 2.749 0.202 0.232 A 348 334 0 0 0 0 [[11, 263]] 1.0 4ixp CAMK_MELK_HUMAN CAMK 4.1e-86 294.6 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4UMTA Q14680 3 333 651.0 47W:1335 Type1 Inactive DFGinter 8.347 9.948 None DFGAsp-rot-in -125.65, -174.91 -147.25, 172.21 200.18, -3.34 77.11, 1.19 311.79, 155.98 -66.5, 145.33 out-out out 11.997 Saltbr-out 13.272 HRD-in -80.71, -59.49 79.99, -2.05 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -17.83 APE9-dihe-na 40.69, -129.51 APE8-dihe-out -75.85, -1.01 APE8-rot-out 51.67 APE67-dihe-in -62.07, -20.63 -51.04, -41.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.174 APE9-dist-out 11.261 N213T,V214A,M215A,Y218V,K219A None None XRAY 1.98 0.214 0.236 A 356 316 15 0 0 15 [[11, 263]] 1.0 4umt CAMK_MELK_HUMAN CAMK 4.6e-88 300.9 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4UMUA Q14680 3 333 651.0 0V0:1334 Type1 Inactive DFGinter 8.166 10.166 None DFGAsp-rot-in -116.79, -162.79 -155.72, 175.05 195.86, -0.92 72.46, 6.06 306.96, 157.96 -72.63, 148.48 out-out out 12.217 Saltbr-out 13.237 HRD-in -78.66, -59.93 79.02, -3.49 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 39.54 APE9-dihe-na 55.48, -131.65 APE8-dihe-out -79.5, 0.32 APE8-rot-out 30.81 APE67-dihe-in -69.91, -20.55 -51.25, -38.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.252 APE9-dist-out 11.079 None None None XRAY 2.02 0.207 0.236 A 356 316 15 0 0 15 [[11, 263]] 1.0 4umu CAMK_MELK_HUMAN CAMK 4.6e-88 300.9 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK PRKAA1 AAPK1_HUMAN 4REDA Q13131 22 360 559.0 No_ligand No_ligand Inactive DFGinter 7.587 8.711 None DFGAsp-rot-in -76.34, -39.91 -91.25, 104.66 182.02, 10.76 -101.3, 16.59 55.39, 86.7 124.85, -0.24 out-out out 12.796 Saltbr-out 10.996 HRD-out -68.9, 144.23 -138.95, 122.97 out-out-out SNCooo out-out ActLoopNT-out 13.073 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 59.47 APE8-rot-out 66.53 APE67-dihe-out -120.17, 127.81 -69.82, 149.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K52A None None XRAY 2.95 0.233 0.277 A 351 326 13 0 0 9 [[27, 279]] 1.0 4red CAMK_PRKAA1_HUMAN CAMK 5e-89 304.1 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 4REDB Q13131 22 360 559.0 No_ligand No_ligand Inactive DFGinter 7.581 8.224 None DFGAsp-rot-in -76.53, -36.41 -94.12, 106.96 180.26, 5.35 -98.58, 14.09 52.09, 86.12 121.55, -8.46 out-out out 12.669 Saltbr-out 11.179 HRD-out -67.54, 143.84 -139.21, 124.67 out-out-out SNCooo out-out ActLoopNT-out 13.157 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -40.52 APE8-rot-out 68.01 APE67-dihe-in -131.1, -88.72 -74.35, 44.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K52A None None XRAY 2.95 0.233 0.277 B 351 331 8 0 0 8 [[27, 279]] 1.0 4red CAMK_PRKAA1_HUMAN CAMK 5e-89 304.1 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK TRIB1 TRIB1_HUMAN 5CEKA Q96RU8 88 342 372.0 No_ligand No_ligand Pseudo DFGinter 8.858 7.037 None DFGAsp-rot-na -98.32, 87.14 -82.08, -7.36 59.01, 999.0 -109.34, 16.03 300.0, 168.59 61.59, 55.88 out-na out 12.089 Saltbr-na 999.0 HRD-in -75.72, -58.41 87.17, -43.21 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanao APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 124.18 APE8-rot-na 59.79 APE67-dihe-out 80.81, -50.83 -77.85, -164.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.209 0.246 A 263 237 18 0 0 13 [[99, 338]] 1.0 5cek CAMK_TRIB1_HUMAN CAMK 9.2e-62 214.7 14 256 243 224 225 226 228 230 120 130 134 202 204 203 205 266 252 247 246 245 244 243 242 241 161 Tribbles homolog 1
CAMK TRIB1 TRIB1_HUMAN 5CEMA Q96RU8 88 364 372.0 No_ligand No_ligand Pseudo DFGinter 9.487 6.83 None DFGAsp-rot-na -85.06, 104.77 -111.16, 5.29 66.22, 999.0 -105.21, 15.47 300.28, 1.5 60.7, 52.63 out-na out 12.027 Saltbr-na 999.0 HRD-in -82.52, -54.12 78.21, -13.8 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_oooo APE10-dihe-na -58.19, 148.96 APE9-dihe-na 66.07, 47.38 APE8-dihe-in -82.13, 123.37 APE8-rot-na 180.29 APE67-dihe-out -72.24, -16.3 -74.98, 72.26 APE12-dist-out 26.802 APE11-dist-out 24.692 APE10-dist-out 20.205 APE9-dist-out 15.941 None None None XRAY 2.1 0.179 0.223 A 292 252 11 0 0 9 [[99, 338]] 1.0 5cem CAMK_TRIB1_HUMAN CAMK 1.3e-61 214.2 14 256 243 224 225 226 228 230 120 130 134 202 204 203 205 266 252 247 246 245 244 243 242 241 161 Tribbles homolog 1
CMGC MAPK14 MK14_HUMAN 4EH9A Q16539 5 354 360.0 IRG:401,0OQ:402 Allosteric,Type3 Inactive DFGinter 10.9 6.206 None DFGAsp-rot-out -97.42, 159.57 -62.33, -60.46 47.45, -4.82 -150.13, 147.17 64.11, 82.71 -78.55, 25.4 in-out in 9.404 Saltbr-out 4.576 HRD-in -71.05, -53.71 82.13, -21.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 115.29 APE9-dihe-na -99.26, 134.28 APE8-dihe-out -59.4, -32.47 APE8-rot-in 294.18 APE67-dihe-in -64.19, -25.37 -57.95, -25.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.356 APE9-dist-out 11.824 None None None XRAY 2.1 0.232 0.28 A 360 334 16 0 0 11 [[24, 308]] 1.0 4eh9 CMGC_MAPK14_HUMAN CMGC 6.1e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3GCPA Q16539 4 352 360.0 SB2:361 Type1 Inactive DFGinter 10.471 9.26 None DFGAsp-rot-out -117.37, 167.72 -120.22, 32.97 66.16, -16.65 -153.57, 150.38 52.4, 89.27 -67.24, 116.69 in-in in 9.161 Saltbr-in 2.949 HRD-in -63.02, -55.34 82.04, -15.88 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 176.81 APE8-rot-out 58.62 APE67-dihe-in -63.93, -20.89 -120.85, 2.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C119S,C162S,A172C,F327L None None XRAY 2.25 0.201 0.276 A 360 337 12 0 0 12 [[24, 308]] 1.0 3gcp CMGC_MAPK14_HUMAN CMGC 4.5e-84 288.3 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 5WJJA Q16539 5 352 360.0 AQY:501 Type1 Inactive DFGinter 10.159 9.062 None DFGAsp-rot-out -113.52, 161.05 -110.02, 23.38 53.99, 6.8 -151.72, 163.67 53.5, 90.99 -95.62, 149.45 in-in in 9.566 Saltbr-in 3.445 HRD-in -66.13, -48.01 74.38, -15.21 in-out-out SNCioo out-out ActLoopNT-out 22.96 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 151.37 APE8-dihe-out -54.87, -43.06 APE8-rot-in 316.01 APE67-dihe-in -61.84, -23.7 -56.22, -24.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.145 None None None XRAY 1.6 0.202 0.237 A 365 338 10 0 0 6 [[24, 308]] 1.0 5wjj CMGC_MAPK14_HUMAN CMGC 8.7e-85 290.6 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 6ANLA Q16539 4 352 360.0 T75:401 Type1 Inactive DFGinter 8.702 9.562 None DFGAsp-rot-out -112.8, 165.91 -107.34, -21.64 285.55, -32.39 -131.97, 3.35 36.97, 78.14 70.96, -173.34 in-in in 9.931 Saltbr-in 3.589 HRD-in -64.58, -50.49 75.67, -10.04 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 173.9 APE8-dihe-out -67.0, -31.89 APE8-rot-in 294.98 APE67-dihe-in -56.18, -24.82 -62.08, -27.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.877 C119S,C162S None None XRAY 2.0 0.209 0.263 A 365 338 11 0 0 11 [[24, 308]] 1.0 6anl CMGC_MAPK14_HUMAN CMGC 8.7e-85 290.6 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 5ML5A Q16539 5 352 360.0 1VI:404 Type1 Inactive DFGinter 10.136 9.242 None DFGAsp-rot-out -111.39, 159.42 -109.35, 34.77 62.79, -17.83 -164.27, 172.15 56.08, 84.45 -90.56, 999.0 in-in in 9.333 Saltbr-in 2.606 HRD-in -70.95, -52.33 83.04, -10.08 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 141.66 APE8-rot-in 289.06 APE67-dihe-in -53.62, -25.52 -105.11, -4.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.195 0.24 A 360 326 22 0 0 14 [[24, 308]] 1.0 5ml5 CMGC_MAPK14_HUMAN CMGC 6.1e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3HUCA Q16539 4 352 360.0 G97:362 Type1 Inactive DFGinter 10.337 9.179 None DFGAsp-rot-out -109.97, 165.2 -105.06, 29.04 56.85, -20.61 179.24, 164.7 62.51, 85.01 -109.68, 999.0 in-in in 9.553 Saltbr-in 2.442 HRD-in -73.07, -53.68 79.88, -13.18 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 145.84 APE9-dihe-na -130.77, 137.71 APE8-dihe-out -61.1, -31.75 APE8-rot-in 284.73 APE67-dihe-in -65.27, -22.19 -58.7, -25.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.125 None None None XRAY 1.8 0.196 0.232 A 360 337 12 0 0 12 [[24, 308]] 1.0 3huc CMGC_MAPK14_HUMAN CMGC 6.1e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3ZS5A Q16539 2 352 360.0 SB2:61000 Type1 Inactive DFGinter 10.234 9.251 None DFGAsp-rot-out -115.27, 172.44 -122.64, 34.9 57.7, -14.42 -156.58, 162.56 53.94, 87.63 -91.34, 146.87 in-in in 9.437 Saltbr-in 2.826 HRD-in -66.65, -51.78 79.0, -9.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -29.47 APE8-dihe-out -65.94, -20.08 APE8-rot-out 57.11 APE67-dihe-in -60.59, -17.67 -110.97, -2.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.437 None None None XRAY 1.6 0.186 0.215 A 362 339 12 0 0 12 [[24, 308]] 1.0 3zs5 CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3ZSGA Q16539 4 352 360.0 T75:400 Type1 Inactive DFGinter 9.869 9.382 None DFGAsp-rot-out -112.39, 162.65 -112.67, 28.78 61.03, -15.39 -156.41, 165.54 53.67, 85.81 -94.27, 155.51 in-in in 9.817 Saltbr-in 3.405 HRD-in -65.93, -52.33 82.35, -11.55 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -19.16 APE8-dihe-out -64.72, -27.97 APE8-rot-out 56.05 APE67-dihe-in -62.96, -19.39 -109.94, 3.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.409 None None None XRAY 1.89 0.191 0.233 A 362 337 12 0 0 12 [[24, 308]] 1.0 3zsg CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 6HWTA Q16539 5 352 360.0 GXH:404 Type1 Inactive DFGinter 9.606 9.249 None DFGAsp-rot-out -109.85, 163.34 -111.83, 32.01 63.66, -21.63 -158.93, 166.76 53.05, 86.7 -101.84, 157.19 in-in in 9.405 Saltbr-in 3.166 HRD-in -68.48, -52.76 78.69, -12.38 in-out-out SNCioo out-out ActLoopNT-out 23.197 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 160.58 APE8-rot-out 199.92 APE67-dihe-in -66.05, -17.36 -114.13, 10.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.204 0.234 A 362 336 12 0 0 11 [[24, 308]] 1.0 6hwt CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 6HWUA Q16539 5 353 360.0 GE5:404 Type1 Inactive DFGinter 9.59 8.968 None DFGAsp-rot-out -118.08, 168.42 -117.72, 42.58 63.49, -18.87 -170.41, 161.53 57.41, 87.05 -97.74, 161.01 in-in in 9.458 Saltbr-in 2.926 HRD-in -69.49, -51.73 75.06, -4.67 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 73.5 APE9-dihe-na -65.73, 137.2 APE8-dihe-out -60.1, -34.07 APE8-rot-in 274.51 APE67-dihe-in -66.54, -24.29 -62.93, -25.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.207 APE9-dist-out 11.553 None None None XRAY 2.3 0.193 0.247 A 362 333 16 0 0 11 [[24, 308]] 1.0 6hwu CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 6HWVA Q16539 5 352 360.0 GEW:404 Type1 Inactive DFGinter 9.996 9.286 None DFGAsp-rot-out -112.84, 163.83 -110.3, 35.34 60.19, -23.19 -165.77, 166.95 54.01, 85.28 -99.22, 157.29 in-in in 9.494 Saltbr-in 2.804 HRD-in -69.21, -52.62 80.0, -9.79 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.66 APE8-rot-out 177.65 APE67-dihe-in -67.08, -18.22 -107.78, 6.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.18 0.197 A 362 336 12 0 0 12 [[24, 308]] 1.0 6hwv CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4EHVA Q16539 5 352 360.0 0SJ:401,0SJ:402,IRG:403,0SJ:404 Type3,Allosteric,Allosteric,Allosteric Inactive DFGinter 10.923 6.276 None DFGAsp-rot-out -99.66, 162.35 -69.64, -55.96 48.23, -19.84 -152.93, 157.53 62.39, 91.72 -108.25, -179.88 in-none in 9.237 Saltbr-none 999.0 HRD-in -69.34, -50.13 82.95, -13.29 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 107.52 APE9-dihe-na -78.18, 127.1 APE8-dihe-out -52.4, -41.18 APE8-rot-in 282.24 APE67-dihe-in -64.93, -23.91 -55.78, -30.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.946 APE9-dist-out 11.005 None None None XRAY 1.6 0.223 0.252 A 360 337 11 0 0 11 [[24, 308]] 1.0 4ehv CMGC_MAPK14_HUMAN CMGC 6.1e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK6 MK06_HUMAN 6YKYA Q16659 18 319 721.0 OWQ:401 Type1 Inactive DFGinter 8.827 5.003 None DFGAsp-rot-out -71.78, 144.73 -71.1, -32.64 295.94, -83.34 -79.99, 115.19 311.82, 124.02 127.81, -16.19 in-out in 9.812 Saltbr-out 8.13 HRD-out -111.51, 110.19 -70.61, -5.41 out-out-out SNCooo out-out ActLoopNT-out 5.241 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -91.65, 9.39 APE9-dihe-na -95.19, 123.93 APE8-dihe-in -73.44, 137.77 APE8-rot-out 188.34 APE67-dihe-in -47.48, -36.76 -86.99, -20.14 APE12-dist-out 18.651 APE11-dist-out 20.197 APE10-dist-out 17.841 APE9-dist-out 8.26 L290V None None XRAY 2.52 0.201 0.251 A 319 281 21 0 0 9 [[20, 316]] 1.0 6yky CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1 301 301 170 171 172 174 176 49 65 69 149 151 150 152 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
CMGC MAPK6 MK06_HUMAN 6YKYD Q16659 14 321 721.0 OWQ:401 Type1 Inactive DFGinter 10.483 4.783 None DFGAsp-rot-out -79.21, 142.3 -63.95, -30.02 305.87, -78.29 -82.92, 88.96 326.01, 122.38 148.68, -14.44 out-out out 13.329 Saltbr-out 11.755 HRD-out -97.47, 116.92 -79.67, -2.76 out-out-out SNCooo out-out ActLoopNT-out 5.246 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -102.9, -29.99 APE9-dihe-na -87.22, 152.15 APE8-dihe-in -86.08, 134.07 APE8-rot-out 192.13 APE67-dihe-in -46.65, -35.13 -86.31, -21.98 APE12-dist-out 20.076 APE11-dist-out 21.384 APE10-dist-out 18.132 APE9-dist-out 8.938 L290V None None XRAY 2.52 0.201 0.251 D 319 301 7 0 0 0 [[20, 316]] 1.0 6yky CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1 301 301 170 171 172 174 176 49 65 69 149 151 150 152 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
CMGC MAPK6 MK06_HUMAN 6YLCD Q16659 13 321 721.0 OXW:401 Type1 Inactive DFGinter 9.834 4.994 None DFGAsp-rot-out -68.6, 151.66 -80.4, -20.68 303.66, -74.94 -82.11, 114.82 290.44, 97.57 115.85, -9.5 out-out out 13.347 Saltbr-out 9.853 HRD-out -103.81, 118.3 -82.36, -0.96 out-out-out SNCooo out-out ActLoopNT-out 5.362 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -102.61, -26.31 APE9-dihe-na -98.13, 139.46 APE8-dihe-in -69.39, 130.27 APE8-rot-out 191.58 APE67-dihe-in -59.56, -27.81 -93.33, -5.47 APE12-dist-out 19.987 APE11-dist-out 21.389 APE10-dist-out 18.196 APE9-dist-out 9.055 L290V None None XRAY 2.43 0.191 0.231 D 319 303 6 0 0 0 [[20, 316]] 1.0 6ylc CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1 301 301 170 171 172 174 176 49 65 69 149 151 150 152 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
NEK NEK1 NEK1_HUMAN 4APCA Q96PY6 1 284 1258.0 No_ligand No_ligand Inactive DFGinter 9.644 5.999 BABtrans DFGAsp-rot-in -56.67, 136.95 -74.99, -38.65 199.33, 2.06 -62.93, 130.11 204.86, 72.11 112.63, -15.33 out-none out 11.485 Saltbr-none 999.0 HRD-out -132.48, 108.44 -75.85, -8.05 none-out-out SNCnoo out-out ActLoopNT-out 5.359 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -88.83, -42.36 APE9-dihe-na -95.57, -114.29 APE8-dihe-in -105.03, 125.23 APE8-rot-in 310.11 APE67-dihe-in -73.53, -9.9 -94.81, -5.15 APE12-dist-out 15.971 APE11-dist-out 20.733 APE10-dist-out 18.867 APE9-dist-out 10.432 T162A None None XRAY 2.1 0.216 0.248 A 350 278 6 0 0 0 [[4, 258]] 1.0 4apc NEK_NEK1_HUMAN NEK 2.1e-117 397.3 1 256 256 145 146 147 149 151 33 51 55 125 127 126 128 185 173 168 167 166 165 164 163 162 81 Serine/threonine-protein kinase Nek1
NEK NEK1 NEK1_HUMAN 4APCB Q96PY6 1 284 1258.0 No_ligand No_ligand Inactive DFGinter 9.552 6.103 BABtrans DFGAsp-rot-out -57.58, 134.02 -75.98, -33.46 49.16, -42.5 -60.99, 130.52 202.95, 70.38 110.42, -15.38 out-out out 11.732 Saltbr-out 12.877 HRD-out -131.41, 107.06 -74.49, -7.52 out-out-out SNCooo out-out ActLoopNT-out 5.352 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -75.97, -42.82 APE9-dihe-na -96.64, -115.4 APE8-dihe-in -106.78, 122.56 APE8-rot-in 310.29 APE67-dihe-in -74.36, -7.84 -93.49, -5.36 APE12-dist-out 15.877 APE11-dist-out 20.629 APE10-dist-out 18.814 APE9-dist-out 10.411 T162A None None XRAY 2.1 0.216 0.248 B 350 279 5 0 0 0 [[4, 258]] 1.0 4apc NEK_NEK1_HUMAN NEK 2.1e-117 397.3 1 256 256 145 146 147 149 151 33 51 55 125 127 126 128 185 173 168 167 166 165 164 163 162 81 Serine/threonine-protein kinase Nek1
NEK NEK1 NEK1_HUMAN 4B9DA Q96PY6 1 284 1258.0 CK7:61285 Type1 Inactive DFGinter 10.305 6.08 BABtrans DFGAsp-rot-out -64.94, 139.98 -87.18, -44.3 53.04, -37.7 -54.24, 126.06 193.16, 81.64 121.24, -18.42 out-none out 11.54 Saltbr-none 999.0 HRD-out -117.2, 113.34 -81.68, 1.37 none-out-out SNCnoo out-out ActLoopNT-out 5.164 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -97.21, -40.86 APE9-dihe-na -102.37, -129.43 APE8-dihe-in -86.61, 121.95 APE8-rot-in 319.16 APE67-dihe-in -71.65, -10.17 -95.47, -0.6 APE12-dist-out 16.151 APE11-dist-out 20.776 APE10-dist-out 18.774 APE9-dist-out 10.678 T162A None None XRAY 1.9 0.196 0.222 A 350 278 6 0 0 0 [[4, 258]] 1.0 4b9d NEK_NEK1_HUMAN NEK 2.1e-117 397.3 1 256 256 145 146 147 149 151 33 51 55 125 127 126 128 185 173 168 167 166 165 164 163 162 81 Serine/threonine-protein kinase Nek1
NEK NEK1 NEK1_HUMAN 4B9DB Q96PY6 1 284 1258.0 CK7:61285 Type1 Inactive DFGinter 10.476 6.148 BABtrans DFGAsp-rot-out -65.92, 139.98 -87.45, -46.22 51.7, -37.83 -48.38, 128.7 190.39, 78.79 118.23, -19.27 out-out out 11.665 Saltbr-out 11.609 HRD-out -108.39, 113.36 -82.3, 1.28 out-out-out SNCooo out-out ActLoopNT-out 5.061 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -82.88, -40.18 APE9-dihe-na -104.73, -128.22 APE8-dihe-in -88.79, 124.64 APE8-rot-in 318.31 APE67-dihe-in -72.39, -9.41 -95.66, -1.52 APE12-dist-out 16.136 APE11-dist-out 20.69 APE10-dist-out 18.673 APE9-dist-out 10.702 T162A None None XRAY 1.9 0.196 0.222 B 350 279 5 0 0 0 [[4, 258]] 1.0 4b9d NEK_NEK1_HUMAN NEK 2.1e-117 397.3 1 256 256 145 146 147 149 151 33 51 55 125 127 126 128 185 173 168 167 166 165 164 163 162 81 Serine/threonine-protein kinase Nek1
NEK NEK2 NEK2_HUMAN 2W5BA P51955 3 271 445.0 AGS:61280 ATPlike Inactive DFGinter 8.504 5.693 None DFGAsp-rot-in -133.84, 63.71 -87.34, 106.84 174.71, -0.91 -95.06, 50.42 207.49, 72.2 -49.75, -30.44 out-out out 12.589 Saltbr-out 12.763 HRD-out -82.64, 121.7 -138.12, 47.77 out-out-out SNCooo out-out ActLoopNT-out 12.438 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -74.41, -42.54 APE9-dihe-na -62.33, 153.14 APE8-dihe-in -108.21, 120.03 APE8-rot-in 313.31 APE67-dihe-out -53.46, -34.47 -75.96, 66.07 APE12-dist-out 14.06 APE11-dist-out 18.785 APE10-dist-out 19.398 APE9-dist-out 15.879 T175A None None XRAY 2.4 0.186 0.245 A 279 263 6 0 0 0 [[8, 271]] 1.0 2w5b NEK_NEK2_HUMAN NEK 3.5e-109 370.2 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK NEK2 NEK2_HUMAN 2W5HA P51955 3 271 445.0 No_ligand No_ligand Inactive DFGinter 8.853 5.406 None DFGAsp-rot-in -145.64, 64.76 -76.5, 122.71 177.47, -12.06 -111.22, 47.01 200.36, 74.35 -55.33, -23.57 out-none out 12.526 Saltbr-none 999.0 HRD-none 999.0, 88.49 -140.73, 52.97 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iooo APE10-dihe-na -80.98, -33.57 APE9-dihe-na -66.5, 141.66 APE8-dihe-in -95.51, 126.28 APE8-rot-in 311.21 APE67-dihe-out -49.54, -31.25 -80.26, 60.18 APE12-dist-in 13.999 APE11-dist-out 18.643 APE10-dist-out 19.67 APE9-dist-out 16.136 T175A None None XRAY 2.33 0.197 0.254 A 279 257 12 0 0 3 [[8, 271]] 1.0 2w5h NEK_NEK2_HUMAN NEK 3.5e-109 370.2 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKH Q9P2K8 584 1006 1649.0 G41:1701 Type1 Inactive DFGinter 8.046 8.437 BABtrans DFGAsp-rot-out -55.61, 130.2 -124.52, 16.67 43.76, 6.34 -106.93, 111.28 188.62, 73.34 126.77, 18.12 out-out out 11.056 Saltbr-out 7.626 HRD-in -81.65, -56.1 78.04, -22.14 out-out-out SNCooo out-out ActLoopNT-out 5.295 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_oooo APE10-dihe-na -63.36, -44.68 APE9-dihe-na -61.4, -37.94 APE8-dihe-out -73.72, -24.45 APE8-rot-none 999.0 APE67-dihe-in -74.17, -2.36 -79.69, -19.77 APE12-dist-out 22.363 APE11-dist-out 21.053 APE10-dist-out 23.953 APE9-dist-out 13.506 D848N None None XRAY 2.3 0.214 0.243 H 318 259 38 0 0 19 [[277, 541], [590, 1001]] 2.0 7qwk OTHER_EIF2AK4-2_HUMAN OTHER 2.2e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKF Q9P2K8 584 1005 1649.0 G41:1701 Type1 Inactive DFGinter 8.037 8.181 None DFGAsp-rot-out -60.18, 141.19 -134.64, 94.13 42.41, 13.86 -155.09, 69.13 206.23, 33.34 148.0, 161.57 out-out out 11.114 Saltbr-out 8.211 HRD-in -90.54, -49.57 66.47, -5.34 out-out-out SNCooo out-out ActLoopNT-out 6.628 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_oooo APE10-dihe-na 134.32, -54.28 APE9-dihe-na -62.87, -46.85 APE8-dihe-out -62.12, -35.02 APE8-rot-none 999.0 APE67-dihe-in -70.96, -4.61 -71.45, -20.51 APE12-dist-out 23.468 APE11-dist-out 21.748 APE10-dist-out 24.316 APE9-dist-out 13.581 D848N None None XRAY 2.3 0.214 0.243 F 318 254 42 0 0 24 [[277, 541], [590, 1001]] 2.0 7qwk OTHER_EIF2AK4-2_HUMAN OTHER 2.2e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER IKBKB IKKB_HUMAN 8OMVE O14920 9 643 756.0 No_ligand No_ligand Inactive DFGinter 7.536 10.902 None DFGAsp-rot-in -105.5, 166.4 59.46, 69.27 196.57, 16.99 -69.45, 93.59 281.39, 127.96 -78.86, -65.73 in-out in 9.168 Saltbr-out 4.713 HRD-in -72.45, -37.03 70.29, -11.28 out-out-out SNCooo out-out ActLoopNT-out 4.682 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiio APE10-dihe-na -157.14, 127.84 APE9-dihe-na -150.61, -127.8 APE8-dihe-out -138.47, -162.6 APE8-rot-out 59.63 APE67-dihe-in -96.12, -64.95 -135.66, 0.49 APE12-dist-in 9.551 APE11-dist-in 11.201 APE10-dist-in 7.793 APE9-dist-out 7.897 S177E,S181E None None XRAY 4.16 0.259 0.299 E 671 566 10 0 0 3 [[15, 449]] 1.0 8omv OTHER_IKBKB_HUMAN OTHER 2.6e-50 178.5 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
STE MAP2K1 MP2K1_HUMAN 5YT3A Q02750 39 382 393.0 ANP:401 ATPlike Inactive DFGinter 6.357 10.383 None DFGAsp-rot-out -128.68, 173.26 63.68, 38.66 290.85, -58.72 -52.93, -21.76 28.6, 36.22 -61.84, 114.84 out-out out 16.315 Saltbr-out 14.589 HRD-in -77.7, -42.23 58.41, 13.61 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 70.97 APE8-rot-none 999.0 APE67-dihe-out -132.4, 139.8 -149.07, 91.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S218D,S222D,T292A,S298A None None XRAY 2.9 0.213 0.289 A 350 297 47 0 0 14 [[68, 361]] 1.0 5yt3 STE_MAP2K1_HUMAN STE 4.9e-97 330.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP3K5 M3K5_HUMAN 2CLQA Q99683 670 940 1374.0 STU:1941 Type1 Inactive DFGinter 5.918 8.469 BABtrans DFGAsp-rot-out -91.39, 129.8 -141.56, 7.65 76.17, -45.04 -79.81, 110.16 226.87, 94.37 134.88, -46.11 out-out out 10.127 Saltbr-out 4.796 HRD-in -81.27, -49.85 78.55, 0.8 out-in-out SNCoio in-out ActLoopNT-in 3.025 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -136.64, 134.41 APE9-dihe-na -79.2, -159.26 APE8-dihe-in -79.76, 137.19 APE8-rot-in 323.06 APE67-dihe-in -73.67, -16.9 -62.96, -40.27 APE12-dist-in 11.61 APE11-dist-out 6.223 APE10-dist-out 10.04 APE9-dist-in 3.702 None None None XRAY 2.3 0.204 0.257 A 295 263 8 0 0 5 [[678, 938]] 1.0 2clq STE_MAP3K5_HUMAN STE 6.1e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 2CLQB Q99683 670 940 1374.0 STU:1941 Type1 Inactive DFGinter 6.564 8.021 BABtrans DFGAsp-rot-out -97.55, 126.7 -140.68, 10.18 80.97, -70.46 -79.54, 109.54 215.05, 109.45 130.73, -46.4 in-none in 9.98 Saltbr-none 999.0 HRD-in -83.48, -49.36 79.39, -1.77 none-in-out SNCnio in-out ActLoopNT-in 3.001 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -136.24, 136.94 APE9-dihe-na -82.54, -165.1 APE8-dihe-in -71.26, 138.19 APE8-rot-in 313.5 APE67-dihe-in -70.89, -23.23 -61.89, -43.74 APE12-dist-none 999.0 APE11-dist-out 6.267 APE10-dist-out 10.013 APE9-dist-in 3.749 None None None XRAY 2.3 0.204 0.257 B 295 259 12 0 0 8 [[678, 938]] 1.0 2clq STE_MAP3K5_HUMAN STE 6.1e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP4K1 M4K1_HUMAN 9BI8A Q92918 6 293 833.0 A1APL:60301 Type1 Inactive DFGinter 10.88 6.392 None DFGAsp-rot-in -84.61, 129.22 -97.99, 100.09 180.71, 4.32 -110.18, 33.34 298.01, 131.21 -69.67, 73.48 out-out out 13.764 Saltbr-out 14.074 HRD-in -72.89, -53.57 81.64, -15.14 out-out-out SNCooo out-out ActLoopNT-out 12.228 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -88.01, -22.61 APE9-dihe-na 97.47, -162.62 APE8-dihe-in -70.31, 141.95 APE8-rot-out 187.73 APE67-dihe-in -58.8, -30.03 -104.05, -8.58 APE12-dist-out 20.556 APE11-dist-out 20.704 APE10-dist-out 21.839 APE9-dist-out 20.928 None None None XRAY 2.25 0.203 0.271 A 311 288 0 0 0 0 [[17, 274]] 1.0 9bi8 STE_MAP4K1_HUMAN STE 5.2e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9BI8B Q92918 6 293 833.0 A1APL:60302 Type1 Inactive DFGinter 10.74 6.23 None DFGAsp-rot-in -97.5, 135.14 -108.73, 95.26 182.29, 9.22 -106.77, 39.31 297.68, 134.76 -83.18, 62.11 out-out out 13.997 Saltbr-out 14.039 HRD-in -72.45, -53.25 76.92, -14.23 out-out-out SNCooo out-out ActLoopNT-out 12.839 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -130.02, -27.74 APE9-dihe-na 93.81, 172.9 APE8-dihe-in -65.36, 145.02 APE8-rot-out 198.59 APE67-dihe-in -58.71, -28.43 -102.52, -7.42 APE12-dist-out 22.486 APE11-dist-out 22.102 APE10-dist-out 20.6 APE9-dist-out 22.057 None None None XRAY 2.25 0.203 0.271 B 311 288 0 0 0 0 [[17, 274]] 1.0 9bi8 STE_MAP4K1_HUMAN STE 5.2e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9N9XA Q92918 6 293 833.0 A1BWL:60303 Type1 Inactive DFGinter 10.661 6.351 None DFGAsp-rot-in -84.76, 134.66 -105.03, 107.01 176.48, 6.62 -114.17, 28.48 294.9, 125.35 -58.6, 75.75 out-out out 13.958 Saltbr-out 13.908 HRD-in -69.29, -54.46 84.81, -14.35 out-out-out SNCooo out-out ActLoopNT-out 12.469 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -81.99, -16.32 APE9-dihe-na 85.41, -173.0 APE8-dihe-in -61.5, 138.0 APE8-rot-out 189.55 APE67-dihe-in -57.89, -33.43 -97.6, -11.25 APE12-dist-out 20.846 APE11-dist-out 20.756 APE10-dist-out 21.579 APE9-dist-out 20.677 None None None XRAY 2.3 0.227 0.276 A 311 288 0 0 0 0 [[17, 274]] 1.0 9n9x STE_MAP4K1_HUMAN STE 5.2e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9N9XB Q92918 5 293 833.0 A1BWL:60303 Type1 Inactive DFGinter 10.659 6.162 None DFGAsp-rot-in -80.37, 148.27 -120.58, 99.48 174.61, 9.38 -108.65, 34.73 297.74, 123.66 -67.08, 76.96 out-out out 14.045 Saltbr-out 13.883 HRD-in -72.97, -55.95 86.29, -23.53 out-out-out SNCooo out-out ActLoopNT-out 13.033 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -142.31, -31.43 APE9-dihe-na 78.86, 177.37 APE8-dihe-in -56.88, 138.49 APE8-rot-out 57.19 APE67-dihe-in -66.47, -29.19 -92.99, -1.5 APE12-dist-out 21.885 APE11-dist-out 21.794 APE10-dist-out 20.426 APE9-dist-out 22.322 None None None XRAY 2.3 0.227 0.276 B 311 289 0 0 0 0 [[17, 274]] 1.0 9n9x STE_MAP4K1_HUMAN STE 5.2e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K4 M4K4_HUMAN 4U3ZA O95819 17 311 1239.0 No_ligand No_ligand Inactive DFGinter 5.504 10.108 None DFGAsp-rot-in -90.3, 128.59 75.45, 163.28 206.87, -10.07 -151.97, 31.14 43.16, 85.73 119.13, -6.79 out-out out 13.995 Saltbr-out 13.772 HRD-in -72.3, -49.26 78.71, -16.24 out-out-out SNCooo out-out ActLoopNT-out 5.305 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -98.57, 126.67 APE9-dihe-na -83.8, -149.21 APE8-dihe-in -69.81, 136.64 APE8-rot-out 191.8 APE67-dihe-in -65.68, -25.19 -91.82, -5.09 APE12-dist-out 18.044 APE11-dist-out 17.229 APE10-dist-out 18.461 APE9-dist-out 9.95 T181E None None XRAY 2.09 0.186 0.249 A 332 282 13 0 0 0 [[25, 289]] 1.0 4u3z STE_MAP4K4_HUMAN STE 2.3e-102 347.7 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4U3YA O95819 17 311 1239.0 No_ligand No_ligand Inactive DFGinter 5.685 10.295 None DFGAsp-rot-in -88.99, 126.24 79.22, 151.13 204.2, -2.83 -137.58, 35.87 48.82, 95.81 105.67, -5.01 out-out out 13.903 Saltbr-out 14.441 HRD-in -83.26, -53.16 70.55, 5.66 out-out-out SNCooo out-out ActLoopNT-out 5.766 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -69.98, -47.61 APE9-dihe-na 95.3, -170.42 APE8-dihe-in -81.29, 138.53 APE8-rot-out 188.11 APE67-dihe-in -65.33, -22.86 -89.45, -12.96 APE12-dist-out 15.771 APE11-dist-out 17.308 APE10-dist-out 19.317 APE9-dist-out 9.836 None None None XRAY 1.45 0.184 0.207 A 332 295 0 0 0 0 [[25, 289]] 1.0 4u3y STE_MAP4K4_HUMAN STE 1.8e-102 348.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
STE PAK1 PAK1_HUMAN 9D50B Q13153 253 542 545.0 A1A2T:601 Type1 Inactive DFGinter 7.208 7.932 None DFGAsp-rot-out -130.13, 169.98 -108.02, 0.22 276.95, -53.87 -119.5, 17.11 301.73, 104.49 -81.4, -34.77 in-out in 9.987 Saltbr-out 5.352 HRD-in -71.88, -57.66 86.42, -21.48 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -63.89, -52.65 APE9-dihe-na -113.94, 174.61 APE8-dihe-in -89.03, 125.57 APE8-rot-in 304.08 APE67-dihe-out -69.25, -19.69 -82.71, 72.13 APE12-dist-out 20.154 APE11-dist-out 16.264 APE10-dist-out 13.821 APE9-dist-out 13.703 D389N,T423E None None XRAY 1.898 0.186 0.23 B 296 275 15 0 0 8 [[270, 521]] 1.0 9d50 STE_PAK1_HUMAN STE 3.4e-94 321.0 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE SLK SLK_HUMAN 4USFA Q9H2G2 19 310 1235.0 6UI:60700 Type1 Inactive DFGinter 8.042 10.058 None DFGAsp-rot-in -117.97, -164.7 -148.31, 161.25 199.82, -1.05 67.07, 10.53 308.47, 138.36 -64.12, 155.64 out-out out 12.27 Saltbr-out 11.521 HRD-in -81.47, -50.79 75.66, -10.69 out-out-out SNCooo out-out ActLoopNT-out 20.081 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 124.78 APE8-rot-in 310.95 APE67-dihe-out -63.58, -25.56 -87.14, 59.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.75 0.198 0.228 A 304 275 17 0 0 13 [[34, 292]] 1.0 4usf STE_SLK_HUMAN STE 9e-97 329.4 1 257 257 172 173 174 176 178 63 79 83 152 154 153 155 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
STE SLK SLK_HUMAN 4USFB Q9H2G2 19 310 1235.0 6UI:60700 Type1 Inactive DFGinter 8.38 9.95 None DFGAsp-rot-in -116.24, -167.43 -147.44, 163.23 196.78, 2.43 64.7, 16.11 306.44, 141.27 -69.71, 155.48 out-out out 11.908 Saltbr-out 10.492 HRD-in -81.17, -51.97 77.33, -10.55 out-out-out SNCooo out-out ActLoopNT-out 19.963 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -129.76, 123.16 APE9-dihe-na 56.23, 51.46 APE8-dihe-in -52.62, 128.43 APE8-rot-in 306.51 APE67-dihe-in -63.75, -23.49 -58.2, -37.55 APE12-dist-none 999.0 APE11-dist-out 7.804 APE10-dist-out 11.968 APE9-dist-in 3.518 None None None XRAY 1.75 0.198 0.228 B 304 283 9 0 0 9 [[34, 292]] 1.0 4usf STE_SLK_HUMAN STE 9e-97 329.4 1 257 257 172 173 174 176 178 63 79 83 152 154 153 155 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
STE STK25 STK25_HUMAN 4NZWB O00506 11 292 426.0 J60:1000 Type1 Inactive DFGinter 10.262 5.963 None DFGAsp-rot-none -75.42, -140.49 -158.88, -45.92 999.0, 999.0 -65.17, 119.32 317.26, 111.8 114.04, -12.12 out-out out 10.07 Saltbr-out 4.302 HRD-in -77.57, -31.02 67.3, -14.73 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -73.59 APE8-dihe-out 136.85, 83.49 APE8-rot-out 37.4 APE67-dihe-in -19.17, -28.72 -28.03, -93.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.737 D158A None None XRAY 3.583 0.214 0.275 B 295 266 16 0 0 14 [[20, 270]] 1.0 4nzw STE_STK25_HUMAN STE 1e-99 339.1 1 257 257 157 158 159 161 163 49 66 70 137 139 138 140 197 185 180 179 178 177 176 175 174 96 Serine/threonine-protein kinase 25
STE STK26 STK26_HUMAN 4FZFB Q9P289 18 297 416.0 DKI:60301 Type1 Inactive DFGinter 9.133 5.046 None DFGAsp-rot-none -57.65, 114.3 -69.67, -9.9 999.0, 999.0 -61.28, -25.81 270.87, 114.11 -63.61, -36.75 out-out out 10.29 Saltbr-out 4.539 HRD-in -96.17, -41.99 66.86, 3.24 out-out-out SNCooo out-out ActLoopNT-out 5.19 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -97.12, 126.65 APE9-dihe-na -67.92, -45.65 APE8-dihe-in -99.44, 130.82 APE8-rot-out 45.3 APE67-dihe-in -58.16, -40.48 -83.63, -4.41 APE12-dist-in 10.491 APE11-dist-in 13.842 APE10-dist-out 12.302 APE9-dist-out 9.632 D162A None None XRAY 3.64 0.255 0.309 B 283 278 2 0 0 0 [[24, 274]] 1.0 4fzf STE_STK26_HUMAN STE 7e-99 336.3 1 257 257 161 162 163 165 167 53 70 74 141 143 142 144 201 189 184 183 182 181 180 179 178 100 Serine/threonine-protein kinase 26
STE TNIK TNIK_HUMAN 8X88A Q9UKE5 15 311 1360.0 No_ligand No_ligand Inactive DFGinter 5.725 9.945 None DFGAsp-rot-in -92.61, 126.66 78.57, 160.72 201.29, -1.03 -147.84, 30.92 39.89, 92.66 114.91, -1.91 out-out out 13.653 Saltbr-out 13.772 HRD-in -94.03, -60.42 72.05, 9.07 out-out-out SNCooo out-out ActLoopNT-out 5.487 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -151.41 APE9-dihe-na -127.93, -146.37 APE8-dihe-in -61.41, 141.34 APE8-rot-out 49.25 APE67-dihe-in -64.12, -24.22 -101.87, 9.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.573 APE9-dist-out 10.143 None None None XRAY 2.7 0.201 0.256 A 304 294 3 0 0 3 [[25, 289]] 1.0 8x88 STE_TNIK_HUMAN STE 3e-105 357.2 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 8X88B Q9UKE5 17 311 1360.0 No_ligand No_ligand Inactive DFGinter 5.705 9.985 None DFGAsp-rot-in -90.48, 120.54 88.19, 158.07 203.69, -8.59 -146.13, 29.2 40.03, 97.67 115.62, 0.39 out-out out 14.512 Saltbr-out 13.634 HRD-in -79.11, -58.67 70.41, 12.41 out-out-out SNCooo out-out ActLoopNT-out 5.012 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -66.52, 155.13 APE9-dihe-na -65.68, 177.97 APE8-dihe-out 49.97, 73.81 APE8-rot-out 69.45 APE67-dihe-in -68.36, -20.09 -87.33, 12.07 APE12-dist-out 17.505 APE11-dist-out 17.455 APE10-dist-out 12.947 APE9-dist-out 10.863 None None None XRAY 2.7 0.201 0.256 B 304 291 4 0 0 0 [[25, 289]] 1.0 8x88 STE_TNIK_HUMAN STE 3e-105 357.2 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TKL ILK ILK_HUMAN 9D5IA Q13418 182 452 452.0 ATP:502 ATPlike Pseudo DFGinter 8.261 6.842 None DFGAsp-rot-na -85.91, 104.5 -70.94, -26.25 293.39, -38.09 -67.8, 1.23 999.0, 999.0 -109.51, 3.6 out-out out 13.611 Saltbr-out 13.777 HRD-out 63.45, 28.98 -91.0, 110.88 out-out-out SNCooo out-out ActLoopNT-out 6.365 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioo APE10-dihe-na -132.95, 115.89 APE9-dihe-na -99.41, -2.16 APE8-dihe-in -138.47, 54.8 APE8-rot-none 999.0 APE67-dihe-in -62.49, -23.03 -64.85, -19.12 APE12-dist-out 14.705 APE11-dist-in 13.99 APE10-dist-out 13.138 APE9-dist-out 13.265 R225A,C346S,C422S None None XRAY 1.5 0.23 0.267 A 271 271 0 0 0 0 [[192, 448]] 1.0 9d5i TKL_ILK_HUMAN TKL 2.8e-62 216.7 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 3KMWA Q13418 185 452 452.0 ATP:502 ATPlike Pseudo DFGinter 8.3 6.975 None DFGAsp-rot-na -80.97, 99.65 -67.11, -24.75 293.32, -37.12 -72.37, 0.55 999.0, 999.0 -103.25, 4.58 out-out out 13.496 Saltbr-out 14.041 HRD-out 59.64, 26.4 -91.04, 116.86 out-out-out SNCooo out-out ActLoopNT-out 6.367 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -122.08, 118.72 APE9-dihe-na -100.74, -5.98 APE8-dihe-in -137.53, 58.2 APE8-rot-none 999.0 APE67-dihe-in -63.57, -23.06 -67.47, -16.05 APE12-dist-out 14.71 APE11-dist-out 14.04 APE10-dist-out 13.057 APE9-dist-out 13.027 C346S,C422S None None XRAY 2.0 0.199 0.203 A 271 268 0 0 0 0 [[192, 448]] 1.0 3kmw TKL_ILK_HUMAN TKL 1.6e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 3REPA Q13418 185 452 452.0 ATP:502 ATPlike Pseudo DFGinter 8.264 6.894 None DFGAsp-rot-na -81.35, 101.61 -70.12, -25.38 296.57, -45.73 -69.18, -5.31 999.0, 999.0 -98.03, -0.84 out-out out 13.359 Saltbr-out 14.12 HRD-out 62.24, 23.62 -86.21, 112.03 out-out-out SNCooo out-out ActLoopNT-out 6.454 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioo APE10-dihe-na -114.84, 122.73 APE9-dihe-na -97.69, -5.36 APE8-dihe-in -136.02, 58.25 APE8-rot-none 999.0 APE67-dihe-in -57.73, -27.19 -63.83, -23.69 APE12-dist-out 14.498 APE11-dist-in 13.981 APE10-dist-out 12.94 APE9-dist-out 13.101 C346S,C422S None None XRAY 1.8 0.206 0.238 A 271 268 0 0 0 0 [[192, 448]] 1.0 3rep TKL_ILK_HUMAN TKL 1.6e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 3KMUA Q13418 185 451 452.0 No_ligand No_ligand Pseudo DFGinter 8.115 7.023 None DFGAsp-rot-none -89.09, 107.07 -68.14, -22.77 999.0, 999.0 -71.11, -14.21 999.0, 999.0 -91.44, 11.74 out-out out 13.695 Saltbr-out 11.012 HRD-out 62.49, 27.89 -91.99, 115.71 out-out-out SNCooo out-out ActLoopNT-out 6.597 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -104.26, 122.36 APE9-dihe-na -103.82, -5.41 APE8-dihe-in -135.57, 56.37 APE8-rot-none 999.0 APE67-dihe-in -59.41, -24.29 -65.19, -22.44 APE12-dist-out 15.046 APE11-dist-out 14.132 APE10-dist-out 12.999 APE9-dist-out 12.97 C346S,C422S None MSE272,MSE301,MSE305,MSE326,MSE331,MSE337,MSE350,MSE375,MSE398,MSE402,MSE425,MSE429,MSE441,MSE449 XRAY 1.8 0.202 0.236 A 271 267 0 0 0 0 [[192, 448]] 1.0 3kmu TKL_ILK_HUMAN TKL 1.6e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 6MIBA Q13418 183 452 452.0 No_ligand No_ligand Pseudo DFGinter 8.103 6.953 None DFGAsp-rot-na -87.41, 112.59 -75.98, -22.17 293.42, -48.57 -67.79, -12.67 999.0, 999.0 -94.49, 5.69 out-out out 14.011 Saltbr-out 12.861 HRD-out 64.37, 30.77 -90.77, 118.17 out-out-out SNCooo out-out ActLoopNT-out 6.381 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -106.73, 116.01 APE9-dihe-na -99.88, -3.31 APE8-dihe-in -137.02, 59.23 APE8-rot-none 999.0 APE67-dihe-in -59.55, -22.39 -68.5, -19.71 APE12-dist-out 15.073 APE11-dist-out 14.122 APE10-dist-out 13.25 APE9-dist-out 12.849 L207W None None XRAY 1.8 0.163 0.208 A 271 270 0 0 0 0 [[192, 448]] 1.0 6mib TKL_ILK_HUMAN TKL 6.9e-62 215.4 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 9D5HA Q13418 182 452 452.0 IRE:701 Type1 Pseudo DFGinter 8.164 7.455 None DFGAsp-rot-na -85.0, 107.56 -70.5, -21.19 315.38, -67.96 -67.61, -12.48 999.0, 999.0 -96.85, 13.46 out-out out 14.137 Saltbr-out 13.105 HRD-out 65.35, 60.25 -109.45, 119.86 out-out-out SNCooo out-out ActLoopNT-out 5.911 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -110.76, 118.05 APE9-dihe-na -102.65, -7.28 APE8-dihe-in -135.36, 55.79 APE8-rot-none 999.0 APE67-dihe-in -64.5, -21.08 -63.95, -18.26 APE12-dist-out 14.988 APE11-dist-out 14.039 APE10-dist-out 13.236 APE9-dist-out 12.723 C346S,R371Q,C422S None None XRAY 1.5 0.197 0.224 A 271 271 0 0 0 0 [[192, 448]] 1.0 9d5h TKL_ILK_HUMAN TKL 1.2e-62 217.9 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 9D5FA Q13418 182 452 452.0 DB8:501 Type1 Pseudo DFGinter 8.366 7.592 None DFGAsp-rot-na -82.6, 123.95 -74.1, -11.79 295.97, -42.89 -66.74, -13.57 999.0, 999.0 -72.54, 5.75 out-out out 14.123 Saltbr-out 15.4 HRD-out -123.23, 159.13 -69.32, -46.01 out-out-out SNCooo out-out ActLoopNT-out 5.554 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -109.48, 117.62 APE9-dihe-na -102.03, -10.5 APE8-dihe-in -134.11, 56.74 APE8-rot-none 999.0 APE67-dihe-in -63.21, -21.45 -62.91, -18.33 APE12-dist-out 15.638 APE11-dist-out 14.874 APE10-dist-out 14.406 APE9-dist-out 8.782 C346S,C422S None None XRAY 1.5 0.191 0.208 A 271 271 0 0 0 0 [[192, 448]] 1.0 9d5f TKL_ILK_HUMAN TKL 1.6e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 9D5GAAAA Q13418 182 452 452.0 A1A2V:501 Type1 Pseudo DFGinter 8.166 7.277 None DFGAsp-rot-na -88.06, 117.11 -74.33, -18.91 299.16, -47.39 -68.4, -19.72 999.0, 999.0 -87.44, 16.53 out-out out 13.771 Saltbr-out 14.663 HRD-out 59.25, 38.65 -103.86, 109.49 out-out-out SNCooo out-out ActLoopNT-out 6.383 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioo APE10-dihe-na -94.88, 120.39 APE9-dihe-na -102.76, -4.36 APE8-dihe-in -137.63, 56.3 APE8-rot-none 999.0 APE67-dihe-in -62.91, -23.12 -64.06, -19.38 APE12-dist-out 14.786 APE11-dist-in 13.895 APE10-dist-out 13.122 APE9-dist-out 13.0 C346S,C422S None None XRAY 1.55 0.195 0.221 AAAA 271 271 0 0 0 0 [[192, 448]] 1.0 9d5g TKL_ILK_HUMAN TKL 1.6e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 9D5PA Q13418 182 452 452.0 AQ4:701 Type1 Pseudo DFGinter 8.061 7.428 None DFGAsp-rot-na -85.71, 111.19 -68.8, -21.89 291.58, -26.21 -73.77, -9.11 999.0, 999.0 -96.7, 8.17 out-out out 13.852 Saltbr-out 12.926 HRD-out 65.12, 30.52 -101.22, 117.74 out-out-out SNCooo out-out ActLoopNT-out 6.577 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioo APE10-dihe-na -117.02, 119.23 APE9-dihe-na -104.23, -7.77 APE8-dihe-in -133.36, 56.94 APE8-rot-none 999.0 APE67-dihe-in -63.3, -21.52 -64.96, -18.17 APE12-dist-out 15.043 APE11-dist-in 13.976 APE10-dist-out 12.889 APE9-dist-out 12.754 C346S,C422S None None XRAY 1.5 0.188 0.21 A 271 271 0 0 0 0 [[192, 448]] 1.0 9d5p TKL_ILK_HUMAN TKL 1.6e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 9D5EA Q13418 182 452 452.0 IRE:701,IRE:702 Type1,Type1 Pseudo DFGinter 8.017 7.524 None DFGAsp-rot-na -89.37, 112.35 -72.14, -19.5 306.68, -66.94 -70.86, -12.91 999.0, 999.0 -92.65, 14.01 out-out out 14.057 Saltbr-out 13.142 HRD-out -82.68, 123.44 -98.83, 148.34 out-out-out SNCooo out-out ActLoopNT-out 6.639 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioo APE10-dihe-na -111.62, 119.46 APE9-dihe-na -104.32, -7.67 APE8-dihe-in -135.99, 56.58 APE8-rot-none 999.0 APE67-dihe-in -63.74, -21.2 -65.26, -17.82 APE12-dist-out 14.857 APE11-dist-in 13.808 APE10-dist-out 12.922 APE9-dist-out 11.885 C346S,C422S None None XRAY 1.5 0.188 0.21 A 271 271 0 0 0 0 [[192, 448]] 1.0 9d5e TKL_ILK_HUMAN TKL 1.6e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL LRRK2 LRRK2_HUMAN 7LHTA Q5S007 558 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 9.844 8.295 None DFGAsp-rot-out -64.84, 122.35 -98.75, -0.04 75.34, -29.64 -71.37, -28.28 172.84, 65.91 -59.04, -42.88 out-out out 11.156 Saltbr-out 7.841 HRD-in -69.75, -40.92 72.72, -9.61 out-out-out SNCooo out-out ActLoopNT-out 9.784 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -82.21, -17.19 APE9-dihe-na 90.26, 154.46 APE8-dihe-in -57.7, 141.99 APE8-rot-in 318.57 APE67-dihe-in -63.97, -43.36 -55.36, -52.39 APE12-dist-in 9.673 APE11-dist-in 10.145 APE10-dist-out 14.096 APE9-dist-in 4.097 None None None EM 3.5 999.0 999.0 A 2527 1795 3 0 0 3 [[1875, 2134]] 1.0 7lht TKL_LRRK2_HUMAN TKL 3.9e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LHTB Q5S007 558 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 9.844 8.295 None DFGAsp-rot-out -64.86, 122.35 -98.72, -0.04 75.34, -29.61 -71.37, -28.3 172.84, 65.9 -59.09, -42.88 out-out out 11.156 Saltbr-out 7.841 HRD-in -69.81, -40.92 72.73, -9.55 out-out-out SNCooo out-out ActLoopNT-out 9.783 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -82.22, -17.15 APE9-dihe-na 90.23, 154.47 APE8-dihe-in -57.69, 142.03 APE8-rot-in 318.55 APE67-dihe-in -64.0, -43.36 -55.37, -52.4 APE12-dist-in 9.672 APE11-dist-in 10.145 APE10-dist-out 14.096 APE9-dist-in 4.097 None None None EM 3.5 999.0 999.0 B 2527 1795 3 0 0 3 [[1875, 2134]] 1.0 7lht TKL_LRRK2_HUMAN TKL 3.9e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LHWA Q5S007 540 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 10.349 8.277 None DFGAsp-rot-out -70.88, 117.76 -93.02, 2.5 58.27, -6.42 -63.92, -24.19 170.47, 59.39 -60.34, -43.84 out-out out 10.98 Saltbr-out 7.258 HRD-in -74.65, -33.87 72.74, -12.12 out-out-out SNCooo out-out ActLoopNT-out 9.631 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -74.42, -8.25 APE9-dihe-na 81.17, 153.49 APE8-dihe-in -58.6, 142.93 APE8-rot-in 304.43 APE67-dihe-in -63.74, -43.48 -51.59, -53.96 APE12-dist-in 10.236 APE11-dist-in 9.457 APE10-dist-out 13.872 APE9-dist-in 4.335 None None None EM 3.7 999.0 999.0 A 2527 1813 3 0 0 3 [[1875, 2134]] 1.0 7lhw TKL_LRRK2_HUMAN TKL 3.9e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LI4A Q5S007 558 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 9.844 8.294 None DFGAsp-rot-out -64.77, 122.33 -98.76, -0.03 75.32, -29.62 -71.41, -28.21 172.83, 65.95 -59.02, -42.88 out-out out 11.157 Saltbr-out 7.842 HRD-in -69.78, -40.92 72.72, -9.67 out-out-out SNCooo out-out ActLoopNT-out 9.784 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -82.19, -17.19 APE9-dihe-na 90.26, 154.48 APE8-dihe-in -57.73, 142.01 APE8-rot-in 318.58 APE67-dihe-in -63.98, -43.36 -55.36, -52.38 APE12-dist-in 9.673 APE11-dist-in 10.145 APE10-dist-out 14.096 APE9-dist-in 4.096 None None None EM 3.1 999.0 999.0 A 2527 1795 3 0 0 3 [[1875, 2134]] 1.0 7li4 TKL_LRRK2_HUMAN TKL 3.9e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO2E Q5S007 12 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 10.549 8.183 None DFGAsp-rot-out -77.97, 115.31 -99.8, 16.1 64.98, -23.23 -71.24, -24.34 179.0, 61.54 -64.41, -41.78 out-out out 11.347 Saltbr-out 7.851 HRD-in -73.2, -35.27 72.81, -10.29 out-out-out SNCooo out-out ActLoopNT-out 9.492 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -67.29, -18.03 APE9-dihe-na 75.0, 160.57 APE8-dihe-in -64.56, 133.01 APE8-rot-in 300.63 APE67-dihe-in -63.84, -35.14 -59.88, -35.03 APE12-dist-in 9.119 APE11-dist-in 10.588 APE10-dist-out 14.447 APE9-dist-in 4.382 None None None EM 4.13 999.0 999.0 E 2527 2275 4 0 0 3 [[1875, 2134]] 1.0 8fo2 TKL_LRRK2_HUMAN TKL 3.9e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO8C Q5S007 12 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 10.404 8.367 None DFGAsp-rot-out -77.76, 115.2 -99.79, 16.57 65.05, -23.2 -70.68, -24.12 178.89, 61.58 -64.22, -41.72 out-out out 11.341 Saltbr-out 7.744 HRD-in -73.07, -35.29 72.76, -10.32 out-out-out SNCooo out-out ActLoopNT-out 9.471 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -67.5, -18.26 APE9-dihe-na 74.89, 160.43 APE8-dihe-in -64.77, 133.4 APE8-rot-in 300.66 APE67-dihe-in -63.6, -35.05 -59.67, -34.64 APE12-dist-in 9.071 APE11-dist-in 10.522 APE10-dist-out 14.411 APE9-dist-in 4.449 None None None EM 3.88 999.0 999.0 C 2527 2270 4 0 0 3 [[1875, 2134]] 1.0 8fo8 TKL_LRRK2_HUMAN TKL 3.9e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO8E Q5S007 12 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 10.415 8.349 None DFGAsp-rot-out -77.68, 115.13 -99.83, 16.55 65.04, -23.26 -70.64, -24.07 178.91, 61.52 -64.18, -41.73 out-out out 11.321 Saltbr-out 7.73 HRD-in -73.0, -35.27 72.87, -10.42 out-out-out SNCooo out-out ActLoopNT-out 9.47 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -67.4, -18.35 APE9-dihe-na 74.93, 160.44 APE8-dihe-in -64.61, 133.34 APE8-rot-in 300.72 APE67-dihe-in -63.56, -35.05 -59.56, -34.8 APE12-dist-in 9.056 APE11-dist-in 10.526 APE10-dist-out 14.406 APE9-dist-in 4.434 None None None EM 3.88 999.0 999.0 E 2527 2270 4 0 0 3 [[1875, 2134]] 1.0 8fo8 TKL_LRRK2_HUMAN TKL 3.9e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO9F Q5S007 12 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 9.348 8.575 None DFGAsp-rot-out -68.36, 152.72 -137.53, 18.95 46.03, -4.12 -81.54, -22.77 187.88, 51.61 -70.19, -36.74 out-out out 11.238 Saltbr-out 8.326 HRD-in -76.93, -42.26 72.06, -11.17 out-out-out SNCooo out-out ActLoopNT-out 9.106 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -70.82, -18.07 APE9-dihe-na 87.94, 175.98 APE8-dihe-in -63.48, 135.16 APE8-rot-in 300.23 APE67-dihe-in -66.37, -45.6 -58.88, -37.04 APE12-dist-in 9.718 APE11-dist-in 10.578 APE10-dist-out 14.122 APE9-dist-in 4.473 None None None EM 3.48 999.0 999.0 F 2527 2289 3 0 0 3 [[1875, 2134]] 1.0 8fo9 TKL_LRRK2_HUMAN TKL 3.9e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8VH5A Q5S007 12 2527 2527.0 ANP:2602 ATPlike Inactive DFGinter 9.746 8.455 None DFGAsp-rot-out -88.01, 106.84 -81.35, 17.64 52.43, -6.32 -78.83, -10.5 197.42, 64.93 -68.71, -22.79 out-out out 11.326 Saltbr-out 8.123 HRD-in -105.05, -49.61 72.56, -5.72 out-out-out SNCooo out-out ActLoopNT-out 8.961 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -67.06, -23.38 APE9-dihe-na 73.72, 168.0 APE8-dihe-in -68.8, 143.98 APE8-rot-out 58.99 APE67-dihe-in -65.74, -54.3 -73.05, -29.17 APE12-dist-in 9.633 APE11-dist-in 8.416 APE10-dist-out 13.344 APE9-dist-in 3.861 None None None EM 4.0 999.0 999.0 A 2527 2221 8 0 0 8 [[1875, 2134]] 1.0 8vh5 TKL_LRRK2_HUMAN TKL 3.9e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8VH5C Q5S007 12 2527 2527.0 ANP:2602 ATPlike Inactive DFGinter 9.746 8.455 None DFGAsp-rot-out -88.01, 106.86 -81.36, 17.7 52.44, -6.38 -78.84, -10.6 197.4, 64.92 -68.66, -22.76 out-out out 11.325 Saltbr-out 8.122 HRD-in -104.99, -49.63 72.52, -5.67 out-out-out SNCooo out-out ActLoopNT-out 8.961 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -66.98, -23.42 APE9-dihe-na 73.64, 168.02 APE8-dihe-in -68.73, 143.93 APE8-rot-out 59.0 APE67-dihe-in -65.76, -54.24 -73.07, -29.13 APE12-dist-in 9.633 APE11-dist-in 8.418 APE10-dist-out 13.345 APE9-dist-in 3.862 None None None EM 4.0 999.0 999.0 C 2527 2221 8 0 0 8 [[1875, 2134]] 1.0 8vh5 TKL_LRRK2_HUMAN TKL 3.9e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LI3A Q5S007 558 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 9.583 8.403 None DFGAsp-rot-out -64.7, 121.5 -105.97, 8.82 66.89, -22.77 -69.04, -26.41 175.66, 65.26 -63.25, -46.61 out-out out 11.401 Saltbr-out 8.121 HRD-in -76.04, -34.97 73.14, -12.04 out-out-out SNCooo out-out ActLoopNT-out 9.664 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -85.32, -9.76 APE9-dihe-na 87.27, 160.92 APE8-dihe-in -56.79, 143.13 APE8-rot-in 300.33 APE67-dihe-in -63.35, -39.62 -56.92, -55.07 APE12-dist-in 10.386 APE11-dist-in 10.363 APE10-dist-out 14.006 APE9-dist-in 3.652 None None None EM 3.8 999.0 999.0 A 2527 1795 3 0 0 3 [[1875, 2134]] 1.0 7li3 TKL_LRRK2_HUMAN TKL 4e-56 197.0 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 9CI3A Q5S007 907 2527 2527.0 No_ligand No_ligand Inactive DFGinter 10.474 8.279 None DFGAsp-rot-out -66.48, 130.02 -90.44, 1.88 58.64, -2.06 -71.41, -23.46 187.57, 71.09 -65.75, -44.61 out-out out 11.224 Saltbr-out 6.863 HRD-in -66.49, -44.27 66.72, -4.67 out-out-out SNCooo out-out ActLoopNT-out 9.42 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -69.6, -18.48 APE9-dihe-na 81.06, 161.8 APE8-dihe-in -67.87, 131.88 APE8-rot-in 311.06 APE67-dihe-in -65.99, -44.62 -57.57, -36.48 APE12-dist-in 9.74 APE11-dist-in 9.32 APE10-dist-out 13.78 APE9-dist-in 4.548 None SEP910,SEP935 SEP910,SEP935 EM 3.96 999.0 999.0 A 2562 1521 3 0 0 3 [[1875, 2134]] 1.0 9ci3 TKL_LRRK2_HUMAN TKL 4e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL MAP3K7 M3K7_HUMAN 8GW3B O43318 27 497 606.0 No_ligand No_ligand Inactive DFGinter 7.307 10.874 None DFGAsp-rot-in -117.09, 7.66 -155.39, 153.46 202.23, -8.2 -120.54, 145.11 298.27, 66.91 -71.46, 166.75 out-out out 13.58 Saltbr-out 9.583 HRD-in -69.79, -54.63 87.1, -10.39 out-out-out SNCooo out-out ActLoopNT-out 9.872 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -79.79, -8.62 APE9-dihe-na 73.87, 28.3 APE8-dihe-out -98.45, 5.64 APE8-rot-in 294.07 APE67-dihe-in -64.55, -14.4 -62.64, -34.37 APE12-dist-in 11.412 APE11-dist-out 15.726 APE10-dist-out 10.031 APE9-dist-out 10.969 None None None XRAY 2.05 0.223 0.258 B 326 277 0 0 0 0 [[36, 286]] 1.0 8gw3 TKL_MAP3K7_HUMAN TKL 4.7e-74 255.3 2 266 265 174 175 176 178 180 63 77 81 153 155 154 156 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
TKL MAP3K7 M3K7_HUMAN 8GW3C O43318 25 497 606.0 No_ligand No_ligand Inactive DFGinter 7.0 10.838 None DFGAsp-rot-in -118.88, 9.98 -158.01, 154.4 204.98, -32.63 -119.85, 146.31 299.32, 82.07 -75.37, 164.49 out-none out 13.13 Saltbr-none 999.0 HRD-in -72.49, -54.99 85.65, -8.16 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -79.4, -8.44 APE9-dihe-na 70.7, 25.06 APE8-dihe-out -96.14, 11.17 APE8-rot-in 290.65 APE67-dihe-in -65.82, -14.66 -63.16, -38.68 APE12-dist-in 9.575 APE11-dist-out 14.505 APE10-dist-out 9.463 APE9-dist-out 10.679 None None None XRAY 2.05 0.223 0.258 C 326 276 3 0 0 3 [[36, 286]] 1.0 8gw3 TKL_MAP3K7_HUMAN TKL 4.7e-74 255.3 2 266 265 174 175 176 178 180 63 77 81 153 155 154 156 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
TKL MAP3K7 M3K7_HUMAN 8GW3D O43318 27 495 606.0 No_ligand No_ligand Inactive DFGinter 7.447 10.844 None DFGAsp-rot-in -119.27, 7.31 -156.44, 153.6 205.24, 1.95 -121.29, 145.39 298.84, 83.74 -68.76, 164.64 out-out out 12.825 Saltbr-out 10.037 HRD-in -70.85, -56.03 85.08, -6.45 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na 89.94, -46.56 APE9-dihe-na 70.84, 30.69 APE8-dihe-out -97.92, 9.04 APE8-rot-in 302.34 APE67-dihe-in -65.06, -14.35 -59.83, -33.2 APE12-dist-in 12.435 APE11-dist-in 12.713 APE10-dist-out 9.855 APE9-dist-out 10.569 None None None XRAY 2.05 0.223 0.258 D 326 274 3 0 0 3 [[36, 286]] 1.0 8gw3 TKL_MAP3K7_HUMAN TKL 4.7e-74 255.3 2 266 265 174 175 176 178 180 63 77 81 153 155 154 156 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
TYR ABL1 ABL1_HUMAN 7W7XA P00519 232 500 1130.0 8DW:601 Type1 Inactive DFGinter 9.558 7.786 BABtrans DFGAsp-rot-out -66.93, 131.45 -122.59, 21.38 47.1, 10.78 -82.27, 129.13 176.71, 100.61 108.56, 2.12 in-out in 8.665 Saltbr-out 7.93 HRD-in -95.77, -52.9 76.52, -0.83 out-out-in SNCooi out-in ActLoopNT-out 5.685 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -108.59, 134.23 APE9-dihe-in -113.71, 159.94 APE8-dihe-in -76.77, 96.08 APE8-rot-na 26.73 APE67-dihe-in -68.1, -14.3 -52.64, -46.2 APE12-dist-na 19.828 APE11-dist-na 15.129 APE10-dist-na 17.953 APE9-dist-na 7.347 None PTR393 PTR393 XRAY 2.0 0.169 0.195 A 272 267 2 0 0 0 [[242, 495]] 1.0 7w7x TYR_ABL1_HUMAN TYR 2.3e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7W7XB P00519 232 500 1130.0 8DW:601 Type1 Inactive DFGinter 9.845 8.188 BABtrans DFGAsp-rot-out -65.38, 135.53 -123.74, 24.69 47.69, 9.78 -80.57, 130.18 174.46, 98.91 106.66, 2.32 in-out in 9.036 Saltbr-out 8.33 HRD-in -94.74, -54.5 74.93, -0.49 out-out-in SNCooi out-in ActLoopNT-out 5.562 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -108.89, 134.45 APE9-dihe-in -117.49, 159.07 APE8-dihe-in -74.94, 99.68 APE8-rot-na 25.49 APE67-dihe-in -68.63, -15.91 -51.43, -45.15 APE12-dist-na 18.715 APE11-dist-na 13.996 APE10-dist-na 17.134 APE9-dist-na 6.992 None PTR393 PTR393 XRAY 2.0 0.169 0.195 B 272 264 5 0 0 0 [[242, 495]] 1.0 7w7x TYR_ABL1_HUMAN TYR 2.3e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 4XEYB P00519 122 504 1130.0 1N1:60601 Type1 Inactive DFGinter 10.001 8.022 BABtrans DFGAsp-rot-out -71.04, 121.63 -84.68, 7.52 349.51, 69.76 -91.76, 101.26 207.86, 90.35 143.13, -1.76 in-out in 8.918 Saltbr-out 8.643 HRD-out -101.25, 126.15 -79.9, -27.01 out-out-in SNCooi out-in ActLoopNT-out 5.422 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -80.63, 133.07 APE9-dihe-in -116.3, 152.74 APE8-dihe-in -66.44, 99.47 APE8-rot-na 21.89 APE67-dihe-in -71.31, -17.26 -44.98, -48.3 APE12-dist-na 18.56 APE11-dist-na 13.923 APE10-dist-na 16.549 APE9-dist-na 6.428 None None None XRAY 2.891 0.232 0.259 B 408 359 9 0 0 0 [[242, 495]] 1.0 4xey TYR_ABL1_HUMAN TYR 8.7e-100 339.5 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7N9GA P00519 233 498 1130.0 STI:60601,1N1:60602 Allosteric,Type1 Inactive DFGinter 10.421 8.187 None DFGAsp-rot-out -69.43, 136.44 -123.08, 27.78 36.77, 17.81 -75.4, -30.96 178.85, 77.99 -98.31, 50.2 in-out in 8.878 Saltbr-out 9.786 HRD-out -92.88, 142.81 -110.01, 0.88 out-out-none SNCoon out-none ActLoopNT-out 5.544 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 170.84 APE8-dihe-in -72.01, 95.09 APE8-rot-na 30.25 APE67-dihe-in -73.75, -10.66 -54.08, -44.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 5.85 None None None XRAY 2.2 0.219 0.251 A 271 250 16 0 0 13 [[242, 495]] 1.0 7n9g TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7N9GC P00519 234 499 1130.0 STI:60601,1N1:60602 Allosteric,Type1 Inactive DFGinter 10.016 7.762 None DFGAsp-rot-out -68.53, 140.81 -120.26, 3.31 42.8, 4.62 -57.57, -42.4 182.82, 108.58 -86.96, 40.71 in-none in 9.439 Saltbr-none 999.0 HRD-out -106.92, 134.12 -80.26, -30.58 none-out-none SNCnon out-none ActLoopNT-out 5.478 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 96.82 APE8-dihe-in -65.53, 99.76 APE8-rot-na 23.57 APE67-dihe-in -73.61, -20.46 -60.17, -42.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.891 None None None XRAY 2.2 0.219 0.251 C 271 233 33 0 0 5 [[242, 495]] 1.0 7n9g TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2G2FA P00519 232 506 1130.0 No_ligand No_ligand Inactive DFGinter 9.904 7.215 None DFGAsp-rot-out -62.11, 127.98 -87.38, -14.52 62.79, -38.92 -64.34, -9.9 184.11, 68.76 -103.31, 15.09 in-out in 8.923 Saltbr-out 8.97 HRD-out -103.65, 121.34 -60.45, -26.89 out-out-in SNCooi out-in ActLoopNT-out 5.537 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -96.48, 145.14 APE9-dihe-in -132.2, 154.35 APE8-dihe-in -76.87, 87.18 APE8-rot-na 28.49 APE67-dihe-in -66.0, -4.27 -34.28, -57.53 APE12-dist-na 21.406 APE11-dist-na 16.576 APE10-dist-na 17.867 APE9-dist-na 7.431 H396P None None XRAY 2.7 0.234 0.286 A 287 275 0 0 0 0 [[242, 495]] 1.0 2g2f TYR_ABL1_HUMAN TYR 7.1e-100 339.6 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 6BL8A P00519 233 502 1130.0 PVB:601 Type1 Inactive DFGinter 8.638 5.129 None DFGAsp-rot-out -71.96, 143.85 -136.17, 39.9 55.89, -9.14 -72.13, -37.4 288.6, 104.47 -92.65, 14.81 in-out in 8.634 Saltbr-out 7.155 HRD-in -90.04, -55.84 74.1, 2.35 out-out-in SNCooi out-in ActLoopNT-out 5.726 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -101.55, 128.85 APE9-dihe-in -120.75, 157.5 APE8-dihe-in -76.2, 98.23 APE8-rot-na 22.7 APE67-dihe-in -70.51, -5.85 -42.21, -49.52 APE12-dist-na 19.841 APE11-dist-na 15.131 APE10-dist-na 17.437 APE9-dist-na 7.088 None None None XRAY 2.5 0.177 0.204 A 272 270 0 0 0 0 [[242, 495]] 1.0 6bl8 TYR_ABL1_HUMAN TYR 1e-99 339.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 6BL8B P00519 233 504 1130.0 PVB:601 Type1 Inactive DFGinter 8.616 5.229 None DFGAsp-rot-out -71.73, 142.55 -134.64, 39.69 56.88, -9.98 -72.51, -38.46 288.36, 104.6 -92.85, 14.3 in-none in 8.487 Saltbr-none 999.0 HRD-in -91.59, -53.55 75.4, -2.02 none-out-in SNCnoi out-in ActLoopNT-out 5.421 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -102.94, 127.06 APE9-dihe-in -119.46, 155.16 APE8-dihe-in -72.29, 100.21 APE8-rot-na 22.45 APE67-dihe-in -69.04, -6.83 -41.1, -50.73 APE12-dist-na 19.223 APE11-dist-na 14.504 APE10-dist-na 17.351 APE9-dist-na 6.845 None None None XRAY 2.5 0.177 0.204 B 272 268 4 0 0 1 [[242, 495]] 1.0 6bl8 TYR_ABL1_HUMAN TYR 1e-99 339.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 8I7SA P00519 232 500 1130.0 6CI:601 Type1 Inactive DFGinter 9.134 7.631 None DFGAsp-rot-out -67.26, 134.08 -124.25, 38.37 45.66, 13.05 -90.11, -15.51 320.43, 108.35 -104.88, 9.69 in-in in 8.711 Saltbr-in 2.997 HRD-in -101.62, -50.5 73.92, -2.89 in-out-in SNCioi out-in ActLoopNT-out 5.643 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -105.21, 132.08 APE9-dihe-in -105.71, 156.86 APE8-dihe-in -74.32, 88.38 APE8-rot-na 26.42 APE67-dihe-in -74.59, -6.02 -50.76, -44.43 APE12-dist-na 19.815 APE11-dist-na 15.13 APE10-dist-na 17.859 APE9-dist-na 7.511 None PTR393 PTR393 XRAY 1.946 0.186 0.216 A 272 262 7 0 0 0 [[242, 495]] 1.0 8i7s TYR_ABL1_HUMAN TYR 2.3e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 8I7SB P00519 232 500 1130.0 6CI:601 Type1 Inactive DFGinter 8.73 7.672 None DFGAsp-rot-out -65.46, 135.7 -123.29, 38.43 48.98, -16.46 -94.21, -15.86 318.08, 102.31 -104.7, 7.72 in-out in 8.739 Saltbr-out 4.579 HRD-in -100.98, -46.35 75.57, -9.9 out-out-in SNCooi out-in ActLoopNT-out 5.393 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -103.26, 135.01 APE9-dihe-in -100.5, 152.85 APE8-dihe-in -79.3, 86.45 APE8-rot-na 26.11 APE67-dihe-in -72.94, -9.36 -50.77, -43.49 APE12-dist-na 18.49 APE11-dist-na 13.88 APE10-dist-na 16.57 APE9-dist-na 7.198 None PTR393 PTR393 XRAY 1.946 0.186 0.216 B 272 264 5 0 0 0 [[242, 495]] 1.0 8i7s TYR_ABL1_HUMAN TYR 2.3e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 8I7ZB P00519 232 500 1130.0 6CI:601 Type1 Inactive DFGinter 8.467 7.129 None DFGAsp-rot-out -66.85, 127.11 -111.9, 44.88 48.0, 3.6 -97.85, -10.98 300.72, 89.67 -118.62, 22.53 in-in in 8.811 Saltbr-in 3.079 HRD-in -103.27, -34.43 69.06, -16.77 in-out-in SNCioi out-in ActLoopNT-out 5.476 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -96.59, 128.54 APE9-dihe-in -113.43, 144.92 APE8-dihe-in -66.08, 92.18 APE8-rot-na 22.51 APE67-dihe-in -69.32, -14.4 -51.28, -44.78 APE12-dist-na 18.584 APE11-dist-na 13.952 APE10-dist-na 16.689 APE9-dist-na 6.907 None PTR393 PTR393 XRAY 2.255 0.177 0.213 B 272 265 4 0 0 0 [[242, 495]] 1.0 8i7z TYR_ABL1_HUMAN TYR 2.3e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7W7YA P00519 232 500 1130.0 8IW:601 Type1 Inactive DFGinter 8.383 7.452 None DFGAsp-rot-in -61.0, 140.15 -123.07, 7.15 215.31, -5.83 -97.99, -19.69 299.86, 99.82 -107.54, 26.38 in-out in 7.832 Saltbr-out 4.324 HRD-in -95.67, -53.61 79.5, -5.33 out-out-in SNCooi out-in ActLoopNT-out 5.716 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -110.53, 135.86 APE9-dihe-in -112.22, 154.02 APE8-dihe-in -72.0, 92.74 APE8-rot-na 26.94 APE67-dihe-in -71.4, -8.88 -51.03, -45.88 APE12-dist-na 19.642 APE11-dist-na 14.989 APE10-dist-na 18.032 APE9-dist-na 7.453 None PTR393 PTR393 XRAY 2.2 0.176 0.201 A 276 269 0 0 0 0 [[242, 495]] 1.0 7w7y TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7W7YB P00519 232 500 1130.0 8IW:601 Type1 Inactive DFGinter 8.706 7.939 None DFGAsp-rot-out -67.02, 132.31 -125.55, 45.99 47.08, 1.9 -104.04, 122.68 325.21, 94.33 94.56, 12.27 in-out in 9.12 Saltbr-out 4.526 HRD-in -107.75, -54.39 71.9, 2.12 out-out-in SNCooi out-in ActLoopNT-out 5.463 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -111.81, 139.55 APE9-dihe-in -122.0, 156.17 APE8-dihe-in -66.34, 94.72 APE8-rot-na 24.45 APE67-dihe-in -67.89, -13.14 -48.19, -46.95 APE12-dist-na 18.655 APE11-dist-na 14.121 APE10-dist-na 17.512 APE9-dist-na 7.157 None PTR393 PTR393 XRAY 2.2 0.176 0.201 B 276 267 2 0 0 0 [[242, 495]] 1.0 7w7y TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 8H7FA P00519 232 500 1130.0 QEW:601 Type1 Inactive DFGinter 8.439 7.331 None DFGAsp-rot-out -69.17, 127.91 -123.7, 53.27 50.62, -18.28 -97.59, -18.49 298.04, 92.12 -115.41, 32.43 in-none in 7.913 Saltbr-none 999.0 HRD-in -98.47, -51.88 73.34, 1.6 none-out-in SNCnoi out-in ActLoopNT-out 5.774 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -98.81, 130.64 APE9-dihe-in -111.12, 149.71 APE8-dihe-in -68.85, 91.65 APE8-rot-na 24.28 APE67-dihe-in -80.23, -2.27 -54.19, -39.54 APE12-dist-na 19.803 APE11-dist-na 15.167 APE10-dist-na 17.763 APE9-dist-na 7.415 None PTR393 PTR393 XRAY 2.45 0.206 0.234 A 277 267 2 0 0 0 [[242, 495]] 1.0 8h7f TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 8H7FB P00519 233 500 1130.0 QEW:601 Type1 Inactive DFGinter 8.625 7.629 None DFGAsp-rot-out -66.82, 132.57 -128.02, 53.13 50.48, -22.83 -102.99, -16.57 308.49, 91.71 -113.57, 28.76 in-none in 8.398 Saltbr-none 999.0 HRD-out -118.2, 104.8 -89.8, 17.52 none-out-in SNCnoi out-in ActLoopNT-out 5.639 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -85.35, 131.94 APE9-dihe-in -101.32, 145.24 APE8-dihe-in -82.14, 94.32 APE8-rot-na 25.72 APE67-dihe-in -72.86, -15.28 -51.55, -45.38 APE12-dist-na 18.504 APE11-dist-na 13.782 APE10-dist-na 16.382 APE9-dist-na 7.368 None PTR393 PTR393 XRAY 2.45 0.206 0.234 B 277 257 11 0 0 0 [[242, 495]] 1.0 8h7f TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 8H7HA P00519 232 500 1130.0 QH9:601 Type1 Inactive DFGinter 8.39 7.687 None DFGAsp-rot-out -66.88, 126.67 -122.6, 45.68 45.63, 9.98 -99.68, -4.7 302.75, 91.96 -123.88, 23.24 in-none in 8.036 Saltbr-none 999.0 HRD-in -99.74, -50.53 75.81, -4.43 none-out-in SNCnoi out-in ActLoopNT-out 5.704 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -107.51, 132.84 APE9-dihe-in -111.46, 154.74 APE8-dihe-in -71.0, 89.59 APE8-rot-na 25.0 APE67-dihe-in -73.93, -5.32 -52.54, -45.5 APE12-dist-na 19.749 APE11-dist-na 15.182 APE10-dist-na 18.067 APE9-dist-na 7.438 None PTR393 PTR393 XRAY 2.278 0.185 0.221 A 277 269 0 0 0 0 [[242, 495]] 1.0 8h7h TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 8H7HB P00519 232 500 1130.0 QH9:601 Type1 Inactive DFGinter 8.489 7.865 None DFGAsp-rot-out -64.21, 134.18 -129.36, 51.05 47.05, 4.6 -106.57, -14.6 307.18, 95.7 -114.91, 23.11 in-none in 8.74 Saltbr-none 999.0 HRD-in -105.06, -54.2 71.08, 0.92 none-out-in SNCnoi out-in ActLoopNT-out 5.593 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -94.95, 127.69 APE9-dihe-in -114.73, 145.44 APE8-dihe-in -67.21, 95.26 APE8-rot-na 23.35 APE67-dihe-in -67.71, -18.52 -54.95, -42.72 APE12-dist-na 18.697 APE11-dist-na 13.937 APE10-dist-na 16.449 APE9-dist-na 6.698 None PTR393 PTR393 XRAY 2.278 0.185 0.221 B 277 258 11 0 0 0 [[242, 495]] 1.0 8h7h TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 4ZOGA P00519 233 501 1130.0 VX6:601 Type1 Inactive DFGinter 9.034 8.188 None DFGAsp-rot-out -67.97, 132.1 -127.82, 25.62 52.96, 14.23 -66.74, -66.47 163.98, 49.73 -79.37, 45.35 out-out out 10.975 Saltbr-out 6.767 HRD-out -91.32, 151.74 -125.52, 16.46 out-out-in SNCooi out-in ActLoopNT-out 5.502 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -110.42, 138.31 APE9-dihe-in -118.45, 160.42 APE8-dihe-in -78.39, 96.94 APE8-rot-na 30.14 APE67-dihe-in -71.46, -10.56 -52.82, -45.85 APE12-dist-na 19.808 APE11-dist-na 15.163 APE10-dist-na 17.423 APE9-dist-na 7.144 None None None XRAY 2.3 0.187 0.233 A 283 269 0 0 0 0 [[242, 495]] 1.0 4zog TYR_ABL1_HUMAN TYR 2.6e-100 341.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7CC2A P00519 233 501 1130.0 FVC:601 Type1 Inactive DFGinter 9.165 8.258 None DFGAsp-rot-out -73.32, 112.44 -109.3, 64.01 49.52, -6.13 -105.28, -20.44 309.47, 116.75 -109.01, 28.74 out-out out 11.085 Saltbr-out 8.369 HRD-in -90.34, -46.17 72.58, 0.36 out-out-in SNCooi out-in ActLoopNT-out 5.617 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -99.21, 129.2 APE9-dihe-in -111.79, 156.63 APE8-dihe-in -66.39, 106.43 APE8-rot-na 344.92 APE67-dihe-in -73.87, -6.7 -58.13, -47.58 APE12-dist-na 19.252 APE11-dist-na 14.472 APE10-dist-na 17.321 APE9-dist-na 6.862 None None None XRAY 2.723 0.196 0.242 A 310 263 6 0 0 0 [[242, 495]] 1.0 7cc2 TYR_ABL1_HUMAN TYR 3.7e-100 340.5 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7CC2B P00519 232 501 1130.0 FVC:601 Type1 Inactive DFGinter 8.979 8.607 None DFGAsp-rot-out -71.77, 114.13 -110.49, 61.26 50.29, -7.49 -109.45, -24.12 312.83, 116.95 -111.64, 29.87 in-none in 9.541 Saltbr-none 999.0 HRD-in -88.51, -47.46 71.59, 1.41 none-out-in SNCnoi out-in ActLoopNT-out 5.646 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -97.35, 131.77 APE9-dihe-in -108.11, 154.53 APE8-dihe-in -67.24, 106.75 APE8-rot-na 21.35 APE67-dihe-in -74.13, -7.58 -57.65, -47.12 APE12-dist-na 19.108 APE11-dist-na 14.389 APE10-dist-na 17.586 APE9-dist-na 7.008 None None None XRAY 2.723 0.196 0.242 B 310 266 4 0 0 0 [[242, 495]] 1.0 7cc2 TYR_ABL1_HUMAN TYR 3.7e-100 340.5 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7DT2A P00519 233 500 1130.0 HJ9:601 Type1 Inactive DFGinter 8.472 7.396 None DFGAsp-rot-out -67.36, 135.71 -126.94, 46.3 45.62, 0.03 -101.94, -14.95 304.55, 98.79 -112.2, 27.67 in-out in 9.0 Saltbr-out 3.798 HRD-in -98.03, -51.7 81.6, -7.87 out-out-in SNCooi out-in ActLoopNT-out 5.749 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -112.44, 133.63 APE9-dihe-in -118.19, 150.76 APE8-dihe-in -62.24, 99.73 APE8-rot-na 22.52 APE67-dihe-in -73.29, -7.91 -58.82, -45.37 APE12-dist-na 19.606 APE11-dist-na 14.956 APE10-dist-na 17.818 APE9-dist-na 7.259 None None None XRAY 2.3 0.208 0.237 A 310 265 3 0 0 0 [[242, 495]] 1.0 7dt2 TYR_ABL1_HUMAN TYR 3.7e-100 340.5 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7DT2B P00519 233 500 1130.0 HJ9:601 Type1 Inactive DFGinter 8.633 7.853 None DFGAsp-rot-out -67.09, 137.47 -125.9, 46.84 45.09, -0.88 -103.12, -16.04 307.9, 99.91 -112.15, 26.28 in-out in 9.594 Saltbr-out 4.084 HRD-in -96.99, -47.74 84.36, -13.26 out-out-in SNCooi out-in ActLoopNT-out 5.563 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -113.22, 136.31 APE9-dihe-in -118.25, 150.94 APE8-dihe-in -59.92, 103.33 APE8-rot-na 21.91 APE67-dihe-in -72.55, -10.92 -57.38, -43.07 APE12-dist-na 18.628 APE11-dist-na 13.965 APE10-dist-na 17.355 APE9-dist-na 6.665 None None None XRAY 2.3 0.208 0.237 B 310 267 1 0 0 0 [[242, 495]] 1.0 7dt2 TYR_ABL1_HUMAN TYR 3.7e-100 340.5 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2G2HA P00519 233 504 1130.0 P16:60532 Type1 Inactive DFGinter 10.338 7.763 None DFGAsp-rot-out -69.8, 139.79 -117.08, 21.66 33.33, 36.73 -74.78, -30.76 182.98, 70.09 -83.63, 27.99 in-out in 8.947 Saltbr-out 8.475 HRD-out -106.09, 125.25 -68.95, -15.96 out-out-in SNCooi out-in ActLoopNT-out 5.622 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -111.55, 116.51 APE9-dihe-in -118.82, 162.2 APE8-dihe-in -67.24, 92.86 APE8-rot-na 32.82 APE67-dihe-in -70.58, -6.79 -39.4, -50.98 APE12-dist-na 19.946 APE11-dist-na 15.235 APE10-dist-na 17.204 APE9-dist-na 6.534 H396P None None XRAY 2.0 0.194 0.213 A 287 272 0 0 0 0 [[242, 495]] 1.0 2g2h TYR_ABL1_HUMAN TYR 7.1e-100 339.6 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 4XEYA P00519 231 503 1130.0 1N1:60601 Type1 Inactive DFGinter 9.993 7.927 None DFGAsp-rot-out -70.89, 123.51 -90.91, 18.27 354.04, 64.18 -87.3, -11.95 199.48, 77.0 -96.54, 13.69 in-out in 8.948 Saltbr-out 8.69 HRD-out -101.8, 125.8 -78.66, -28.68 out-out-in SNCooi out-in ActLoopNT-out 5.393 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -77.59, 140.17 APE9-dihe-in -145.27, 142.92 APE8-dihe-in -62.13, 98.18 APE8-rot-na 23.13 APE67-dihe-in -73.29, -19.48 -49.65, -41.78 APE12-dist-na 18.73 APE11-dist-na 14.108 APE10-dist-na 16.542 APE9-dist-na 6.588 None None None XRAY 2.891 0.232 0.259 A 408 269 4 0 0 0 [[242, 495]] 1.0 4xey TYR_ABL1_HUMAN TYR 8.7e-100 339.5 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 8I7ZA P00519 232 499 1130.0 6CI:601,BAL:602 Type1,Type1 Inactive DFGinter 8.675 7.469 None DFGAsp-rot-out -68.15, 124.34 -115.26, 44.89 50.38, 8.65 -92.28, -20.89 299.64, 92.88 -113.55, 33.09 in-none in 9.013 Saltbr-none 999.0 HRD-in -101.45, -51.38 75.46, -1.93 none-out-in SNCnoi out-in ActLoopNT-out 5.735 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -105.91, 129.83 APE9-dihe-in -107.25, 158.29 APE8-dihe-in -77.21, 88.15 APE8-rot-na 26.6 APE67-dihe-in -78.48, -3.49 -49.13, -44.82 APE12-dist-na 19.991 APE11-dist-na 15.346 APE10-dist-na 18.074 APE9-dist-na 7.513 None PTR393 PTR393 XRAY 2.255 0.177 0.213 A 272 258 10 0 0 0 [[242, 495]] 1.0 8i7z TYR_ABL1_HUMAN TYR 2.3e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 4YC8A P00519 233 501 1130.0 4B7:601 Type1.5_Front Inactive DFGinter 9.254 9.479 None DFGAsp-rot-out -68.71, 128.66 -122.3, 46.03 51.01, 2.09 -98.31, 2.86 321.16, 121.85 -137.07, 20.9 out-none out 11.142 Saltbr-none 999.0 HRD-in -85.64, -50.32 70.16, -2.63 none-out-in SNCnoi out-in ActLoopNT-out 5.44 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -94.08, 143.55 APE9-dihe-in -125.76, 160.26 APE8-dihe-in -76.74, 87.45 APE8-rot-na 25.75 APE67-dihe-in -57.03, -17.99 -35.8, -54.26 APE12-dist-na 19.127 APE11-dist-na 14.45 APE10-dist-na 17.471 APE9-dist-na 6.747 None None None XRAY 2.9 0.199 0.24 A 287 259 10 0 0 0 [[242, 495]] 1.0 4yc8 TYR_ABL1_HUMAN TYR 2.8e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 4YC8B P00519 233 502 1130.0 4B7:601 Type1.5_Front Inactive DFGinter 9.555 9.692 None DFGAsp-rot-out -74.12, 129.26 -121.25, 39.81 53.04, -9.3 -90.85, -3.87 317.47, 128.16 -153.9, 45.6 out-none out 10.822 Saltbr-none 999.0 HRD-in -86.46, -51.93 71.35, -5.5 none-out-in SNCnoi out-in ActLoopNT-out 5.444 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -108.97, 118.68 APE9-dihe-in -109.17, 158.88 APE8-dihe-in -76.82, 85.24 APE8-rot-na 25.02 APE67-dihe-in -65.91, -22.69 -34.29, -47.11 APE12-dist-na 19.669 APE11-dist-na 14.989 APE10-dist-na 17.785 APE9-dist-na 6.93 None None None XRAY 2.9 0.199 0.24 B 287 264 6 0 0 0 [[242, 495]] 1.0 4yc8 TYR_ABL1_HUMAN TYR 2.8e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 9KS5A P00519 233 500 1130.0 A1EG1:271 Type1.5_Front Inactive DFGinter 8.73 5.596 None DFGAsp-rot-out -72.67, 142.35 -137.94, 44.53 59.76, -14.4 -78.62, -20.52 286.29, 105.37 -105.91, 20.09 in-na in 9.005 Saltbr-na 6.545 HRD-in -99.23, -52.74 79.62, -6.89 na-out-in SNCaoi out-in ActLoopNT-out 5.808 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -110.95, 133.03 APE9-dihe-in -106.8, 158.22 APE8-dihe-in -76.47, 95.45 APE8-rot-na 26.95 APE67-dihe-in -74.68, -6.25 -55.43, -44.13 APE12-dist-na 19.819 APE11-dist-na 15.248 APE10-dist-na 18.1 APE9-dist-na 7.545 None PTR393 A1EG1271,PTR393 XRAY 2.2 0.172 0.212 A 272 267 1 0 0 0 [[242, 495]] 1.0 9ks5 TYR_ABL1_HUMAN TYR 1.7e-98 335.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 9KS5B P00519 233 500 1130.0 A1EG1:271 Type1.5_Front Inactive DFGinter 8.971 5.847 None DFGAsp-rot-out -69.26, 149.18 -127.32, 25.05 44.91, 11.91 -69.17, -24.35 300.43, 107.89 -96.85, 31.16 in-na in 8.96 Saltbr-na 6.29 HRD-out -120.48, 122.49 -83.95, -2.51 na-out-in SNCaoi out-in ActLoopNT-out 5.464 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -105.41, 141.36 APE9-dihe-in -120.7, 148.99 APE8-dihe-in -66.45, 102.07 APE8-rot-na 24.98 APE67-dihe-in -72.47, -9.8 -51.6, -47.65 APE12-dist-na 18.424 APE11-dist-na 14.058 APE10-dist-na 17.265 APE9-dist-na 6.892 None PTR393 A1EG1271,PTR393 XRAY 2.2 0.172 0.212 B 272 268 0 0 0 0 [[242, 495]] 1.0 9ks5 TYR_ABL1_HUMAN TYR 1.7e-98 335.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL2 ABL2_HUMAN 3HMIA P42684 279 546 1182.0 DKI:1 Type1 Inactive DFGinter 9.164 4.826 None DFGAsp-rot-out -59.51, 142.63 -137.26, 25.26 50.98, 22.53 -75.0, 160.51 298.16, 114.52 70.44, 20.34 in-in in 8.257 Saltbr-in 2.503 HRD-in -92.76, -51.88 76.23, -2.59 in-out-in SNCioi out-in ActLoopNT-out 5.787 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -106.13, 129.9 APE9-dihe-in -117.54, 160.6 APE8-dihe-in -76.74, 91.54 APE8-rot-na 26.07 APE67-dihe-in -69.21, -5.26 -46.03, -53.32 APE12-dist-na 19.205 APE11-dist-na 14.374 APE10-dist-na 16.846 APE9-dist-na 6.851 None None None XRAY 1.65 0.19 0.234 A 292 268 0 0 0 0 [[288, 541]] 1.0 3hmi TYR_ABL2_HUMAN TYR 2.4e-98 334.6 1 260 260 426 427 428 430 432 317 332 336 406 408 407 409 467 455 450 449 448 447 446 445 444 362 Tyrosine-protein kinase ABL2
TYR BMX BMX_HUMAN 3SXRA P51813 411 671 675.0 1N1:60001 Type1 Inactive DFGinter 7.882 8.167 BABtrans DFGAsp-rot-out -93.57, 121.18 -103.19, -9.04 59.74, -50.02 -51.22, 114.45 184.77, 74.21 62.74, 18.94 out-out out 10.805 Saltbr-out 7.559 HRD-out -99.0, 124.02 -80.22, -7.53 out-in-in SNCoii in-in ActLoopNT-in 2.835 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -95.14, 119.04 APE9-dihe-in -94.0, 160.01 APE8-dihe-in -48.96, 127.48 APE8-rot-na 331.52 APE67-dihe-in -68.66, -11.59 -65.07, -24.25 APE12-dist-na 10.029 APE11-dist-na 7.549 APE10-dist-na 12.042 APE9-dist-na 5.186 Q432K,Q611M,D617T,Q620E None None XRAY 2.4 0.189 0.231 A 268 257 4 0 0 0 [[417, 668]] 1.0 3sxr TYR_BMX_HUMAN TYR 3.2e-93 317.8 1 260 260 553 554 555 557 559 445 460 464 533 535 534 536 594 582 577 576 575 574 573 572 571 490 Cytoplasmic tyrosine-protein kinase BMX
TYR BMX BMX_HUMAN 3SXRB P51813 411 671 675.0 1N1:60002 Type1 Inactive DFGinter 7.708 8.272 BABtrans DFGAsp-rot-out -92.79, 121.27 -96.68, -12.13 57.64, -61.14 -49.05, 115.54 186.98, 71.37 61.78, 19.24 out-out out 10.803 Saltbr-out 8.097 HRD-out -100.92, 124.05 -80.64, -7.7 out-in-in SNCoii in-in ActLoopNT-in 2.845 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -93.81, 125.57 APE9-dihe-in -101.37, 158.16 APE8-dihe-in -49.48, 128.1 APE8-rot-na 332.21 APE67-dihe-in -66.79, -11.14 -62.63, -27.73 APE12-dist-na 9.946 APE11-dist-na 7.447 APE10-dist-na 11.944 APE9-dist-na 5.19 Q432K,Q611M,D617T,Q620E None None XRAY 2.4 0.189 0.231 B 268 255 6 0 0 0 [[417, 668]] 1.0 3sxr TYR_BMX_HUMAN TYR 3.2e-93 317.8 1 260 260 553 554 555 557 559 445 460 464 533 535 534 536 594 582 577 576 575 574 573 572 571 490 Cytoplasmic tyrosine-protein kinase BMX
TYR BMX BMX_HUMAN 3SXSA P51813 411 671 675.0 PP2:60001 Type1 Inactive DFGinter 8.876 7.889 BABtrans DFGAsp-rot-out -95.61, 121.24 -113.83, -1.35 62.76, 11.54 -56.54, 124.12 176.46, 76.51 70.61, 15.34 out-out out 10.716 Saltbr-out 10.788 HRD-out -98.32, 130.38 -82.0, -12.25 out-in-in SNCoii in-in ActLoopNT-in 2.877 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -91.4, 107.31 APE9-dihe-in -93.49, 162.66 APE8-dihe-in -48.34, 121.12 APE8-rot-na 328.7 APE67-dihe-in -67.4, -11.35 -59.38, -25.39 APE12-dist-na 10.326 APE11-dist-na 7.505 APE10-dist-na 12.208 APE9-dist-na 5.385 Q432K,Q611M,D617T,Q620E None None XRAY 1.89 0.18 0.209 A 268 261 0 0 0 0 [[417, 668]] 1.0 3sxs TYR_BMX_HUMAN TYR 3.2e-93 317.8 1 260 260 553 554 555 557 559 445 460 464 533 535 534 536 594 582 577 576 575 574 573 572 571 490 Cytoplasmic tyrosine-protein kinase BMX
TYR BMX BMX_HUMAN 6I99A P51813 411 671 675.0 H88:60701 Type1 Inactive DFGinter 10.504 7.133 BABtrans DFGAsp-rot-out -92.78, 130.3 -132.82, 14.07 63.72, 6.85 -70.86, 131.07 175.95, 70.63 64.29, 18.34 out-out out 11.691 Saltbr-out 8.531 HRD-out -100.62, 121.88 -82.1, -7.03 out-in-in SNCoii in-in ActLoopNT-in 3.12 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -90.26, 112.05 APE9-dihe-in -95.39, 166.08 APE8-dihe-in -53.58, 127.81 APE8-rot-na 330.45 APE67-dihe-in -65.74, -5.97 -74.9, -17.09 APE12-dist-na 9.895 APE11-dist-na 7.345 APE10-dist-na 11.897 APE9-dist-na 5.44 Q432K,Q611M,D617T,Q620E None None XRAY 2.001 0.234 0.259 A 278 261 0 0 0 0 [[417, 668]] 1.0 6i99 TYR_BMX_HUMAN TYR 3.6e-93 317.6 1 260 260 553 554 555 557 559 445 460 464 533 535 534 536 594 582 577 576 575 574 573 572 571 490 Cytoplasmic tyrosine-protein kinase BMX
TYR BMX BMX_HUMAN 6I99B P51813 411 671 675.0 H88:60701 Type1 Inactive DFGinter 9.251 7.233 BABtrans DFGAsp-rot-out -90.14, 131.24 -131.91, 13.25 64.23, 7.13 -71.54, 128.59 176.43, 70.05 63.87, 19.15 out-out out 10.23 Saltbr-out 9.251 HRD-out -99.74, 124.37 -81.83, -9.5 out-in-in SNCoii in-in ActLoopNT-in 3.066 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -90.48, 114.54 APE9-dihe-in -91.05, 166.61 APE8-dihe-in -52.06, 126.92 APE8-rot-na 330.29 APE67-dihe-in -65.72, -7.18 -74.8, -16.87 APE12-dist-na 10.048 APE11-dist-na 7.696 APE10-dist-na 11.898 APE9-dist-na 5.161 Q432K,Q611M,D617T,Q620E None None XRAY 2.001 0.234 0.259 B 278 261 0 0 0 0 [[417, 668]] 1.0 6i99 TYR_BMX_HUMAN TYR 3.6e-93 317.6 1 260 260 553 554 555 557 559 445 460 464 533 535 534 536 594 582 577 576 575 574 573 572 571 490 Cytoplasmic tyrosine-protein kinase BMX
TYR BTK BTK_HUMAN 5XYZA Q06187 394 656 659.0 GYL:701 Type1 Inactive DFGinter 9.347 8.304 BABtrans DFGAsp-rot-out -99.77, 139.1 -95.47, 13.14 59.38, -9.07 -102.26, 131.3 176.17, 60.97 88.39, 12.77 out-out out 11.578 Saltbr-out 9.255 HRD-in -78.14, -61.12 90.65, -27.42 out-out-none SNCoon out-none ActLoopNT-out 5.228 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 77.34 APE8-dihe-in -83.17, 111.34 APE8-rot-na 20.92 APE67-dihe-in -73.15, -5.2 -57.61, -54.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.495 None None None XRAY 2.64 0.268 0.326 A 265 230 33 0 0 14 [[402, 653]] 1.0 5xyz TYR_BTK_HUMAN TYR 5.7e-93 316.9 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 5XYZB Q06187 394 656 659.0 GYL:701 Type1 Inactive DFGinter 9.433 8.075 BABtrans DFGAsp-rot-out -80.9, 137.65 -92.66, -0.21 64.02, -9.21 -77.59, 136.6 176.7, 69.08 72.83, 36.08 out-out out 11.387 Saltbr-out 9.674 HRD-in -68.79, -59.6 106.37, -54.65 out-out-none SNCoon out-none ActLoopNT-out 5.327 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 75.53 APE8-dihe-in -66.49, 110.19 APE8-rot-na 22.3 APE67-dihe-in -70.95, -22.66 -57.21, -50.35 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.656 None None None XRAY 2.64 0.268 0.326 B 265 234 29 0 0 14 [[402, 653]] 1.0 5xyz TYR_BTK_HUMAN TYR 5.7e-93 316.9 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 7YC9A Q06187 395 658 659.0 IS4:701 Type1 Inactive DFGinter 8.002 8.789 BABtrans DFGAsp-rot-out -86.32, 131.84 -104.1, 6.91 55.99, 40.31 -65.2, 125.85 176.47, 71.74 60.46, 29.78 out-out out 11.714 Saltbr-out 13.168 HRD-in -89.69, -58.41 77.25, -3.96 out-out-in SNCooi out-in ActLoopNT-out 8.711 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -112.07, 157.14 APE9-dihe-in -156.9, 156.06 APE8-dihe-in -80.91, 97.28 APE8-rot-na 28.13 APE67-dihe-in -74.5, -5.29 -49.69, -51.23 APE12-dist-na 18.249 APE11-dist-na 16.172 APE10-dist-na 13.526 APE9-dist-na 6.316 None None None XRAY 1.4 0.167 0.187 A 269 264 0 0 0 0 [[402, 653]] 1.0 7yc9 TYR_BTK_HUMAN TYR 6.1e-93 316.9 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 3OCTA Q06187 394 656 659.0 1N1:663 Type1 Inactive DFGinter 9.551 8.047 BABtrans DFGAsp-rot-out -83.49, 139.01 -103.95, 15.92 57.03, 7.8 -87.02, 132.92 181.28, 97.3 77.87, 26.97 in-out in 9.203 Saltbr-out 7.745 HRD-in -70.28, -48.13 67.57, -13.36 out-out-none SNCoon out-none ActLoopNT-out 5.38 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 95.42 APE8-dihe-in -60.66, 106.57 APE8-rot-na 28.18 APE67-dihe-in -77.0, -13.84 -55.35, -41.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 5.71 V555R None None XRAY 1.95 0.199 0.251 A 265 244 19 0 0 14 [[402, 653]] 1.0 3oct TYR_BTK_HUMAN TYR 2.4e-93 318.2 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 6NFIA Q06187 392 659 659.0 KLP:701 Type1 Inactive DFGinter 9.143 7.996 None DFGAsp-rot-out -88.38, 102.06 -66.25, -30.62 59.43, -36.53 -22.04, 98.6 180.01, 49.84 74.77, 999.0 out-out out 10.792 Saltbr-out 7.783 HRD-in -72.39, -52.0 75.98, -4.69 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 84.4 APE9-dihe-in -72.68, 133.55 APE8-dihe-in -78.11, 68.48 APE8-rot-na 34.66 APE67-dihe-in -67.64, -17.9 -60.47, -41.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.432 None None None XRAY 2.41 0.22 0.248 A 268 243 25 0 0 16 [[402, 653]] 1.0 6nfi TYR_BTK_HUMAN TYR 6e-93 316.9 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR CSK CSK_HUMAN 1BYGA P41240 187 448 450.0 STU:501 Type1 Inactive DFGinter 10.86 7.923 BABtrans DFGAsp-rot-out -99.17, 153.06 -105.84, -7.01 67.94, 21.41 -68.56, 146.18 156.4, 90.07 -161.79, 133.09 out-out out 14.775 Saltbr-out 12.646 HRD-in -79.54, -44.6 72.05, -5.51 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.52 APE8-dihe-in -71.25, 96.92 APE8-rot-na 16.81 APE67-dihe-in -75.84, -8.12 -42.46, -43.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.292 None None None XRAY 2.4 0.199 0.287 A 278 246 16 0 0 12 [[195, 442]] 1.0 1byg TYR_CSK_HUMAN TYR 1.2e-87 299.5 1 260 260 331 332 333 335 337 222 236 240 311 313 312 314 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
TYR DDR1 DDR1_HUMAN 6Y23A Q08345 574 907 913.0 No_ligand No_ligand Inactive DFGinter 10.153 7.308 None DFGAsp-rot-out -140.3, -158.95 -155.89, 34.86 48.85, 52.7 -96.49, -19.82 306.08, 111.29 -54.16, -38.8 in-out in 7.431 Saltbr-out 4.303 HRD-in -69.02, -55.97 80.69, 2.43 out-out-in SNCooi out-in ActLoopNT-out 17.592 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -133.93, 116.48 APE9-dihe-in -127.74, 145.71 APE8-dihe-in -88.51, 68.54 APE8-rot-na 35.64 APE67-dihe-in -68.64, -17.14 -58.48, -33.24 APE12-dist-na 999.0 APE11-dist-na 12.248 APE10-dist-na 7.88 APE9-dist-na 7.176 Y569F,Y586F None None XRAY 2.58 0.228 0.27 A 350 305 27 0 0 3 [[610, 907]] 1.0 6y23 TYR_DDR1_HUMAN TYR 2.3e-92 315.0 1 260 260 783 784 785 787 789 655 672 676 763 765 764 766 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR DDR1 DDR1_HUMAN 6Y23B Q08345 574 910 913.0 No_ligand No_ligand Inactive DFGinter 10.177 7.489 None DFGAsp-rot-out -147.65, -164.17 -143.7, 24.01 51.14, 77.13 -83.51, -17.89 309.63, 115.78 -53.01, -42.7 in-out in 7.401 Saltbr-out 4.538 HRD-in -62.79, -53.56 80.0, -6.1 out-out-none SNCoon out-none ActLoopNT-out 17.396 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 122.54 APE9-dihe-in -139.37, 143.31 APE8-dihe-in -88.22, 70.91 APE8-rot-na 34.24 APE67-dihe-in -65.16, -14.5 -56.89, -35.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 7.79 APE9-dist-na 7.245 Y569F,Y586F None None XRAY 2.58 0.228 0.27 B 350 301 30 0 0 5 [[610, 907]] 1.0 6y23 TYR_DDR1_HUMAN TYR 2.3e-92 315.0 1 260 260 783 784 785 787 789 655 672 676 763 765 764 766 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR DDR1 DDR1_HUMAN 6Y23C Q08345 574 911 913.0 No_ligand No_ligand Inactive DFGinter 10.326 7.424 None DFGAsp-rot-out -131.36, -161.95 -146.38, 29.72 55.51, -3.32 -92.15, -18.74 310.61, 115.72 -49.18, -37.85 in-out in 7.603 Saltbr-out 5.078 HRD-in -65.34, -54.8 81.25, 2.61 out-out-none SNCoon out-none ActLoopNT-out 17.518 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 131.97 APE9-dihe-in -138.28, 145.82 APE8-dihe-in -85.36, 72.32 APE8-rot-na 34.45 APE67-dihe-in -71.14, -17.59 -62.42, -29.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.108 APE9-dist-na 7.111 Y569F,Y586F None None XRAY 2.58 0.228 0.27 C 350 305 33 0 0 5 [[610, 907]] 1.0 6y23 TYR_DDR1_HUMAN TYR 2.3e-92 315.0 1 260 260 783 784 785 787 789 655 672 676 763 765 764 766 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR DDR1 DDR1_HUMAN 6BRJA Q08345 605 913 913.0 VX6:60901 Type1 Inactive DFGinter 9.842 6.444 None DFGAsp-rot-out -75.98, 130.59 -108.73, 22.4 56.75, -10.93 -131.46, 172.46 67.8, 95.77 -125.27, 159.76 in-in in 8.607 Saltbr-in 2.475 HRD-in -69.59, -46.48 76.5, -9.43 in-out-in SNCioi out-in ActLoopNT-out 18.162 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -74.43, 114.86 APE9-dihe-in -119.04, 131.61 APE8-dihe-in -82.29, 70.03 APE8-rot-na 39.02 APE67-dihe-in -70.78, -15.74 -55.16, -32.48 APE12-dist-na 18.237 APE11-dist-na 14.849 APE10-dist-na 11.084 APE9-dist-na 7.365 None None None XRAY 2.231 0.189 0.223 A 351 274 35 0 0 0 [[610, 907]] 1.0 6brj TYR_DDR1_HUMAN TYR 2.3e-92 315.0 1 260 260 783 784 785 787 789 655 672 676 763 765 764 766 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR DDR1 DDR1_HUMAN 6BSDA Q08345 604 912 913.0 1N1:60901 Type1 Inactive DFGinter 9.948 9.844 None DFGAsp-rot-out -87.87, 155.34 -64.16, -24.42 54.63, -23.83 174.69, 170.82 68.3, 89.44 55.93, 999.0 in-in in 8.37 Saltbr-in 2.735 HRD-in -61.68, -56.93 83.98, -4.33 in-out-in SNCioi out-in ActLoopNT-out 19.848 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -66.74, 115.57 APE9-dihe-in -116.16, 127.65 APE8-dihe-in -81.76, 68.68 APE8-rot-na 34.21 APE67-dihe-in -66.93, -20.25 -61.43, -30.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.146 None None None XRAY 2.606 0.186 0.255 A 351 278 31 0 0 2 [[610, 907]] 1.0 6bsd TYR_DDR1_HUMAN TYR 2.3e-92 315.0 1 260 260 783 784 785 787 789 655 672 676 763 765 764 766 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR EGFR EGFR_HUMAN 8H7XB P00533 697 1018 1210.0 No_ligand No_ligand Inactive DFGinter 8.474 4.539 None DFGAsp-rot-out -64.56, 138.69 -118.16, 46.75 59.26, -13.66 -84.7, 147.88 264.74, 132.9 65.94, 48.18 in-in in 7.861 Saltbr-in 2.743 HRD-in -95.26, -40.89 71.41, -6.98 in-out-none SNCion out-none ActLoopNT-out 5.284 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.76 APE8-dihe-in -79.73, 83.74 APE8-rot-na 34.28 APE67-dihe-in -52.0, -45.23 -70.34, -44.7 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.766 T790M,C797S None None XRAY 3.404 0.189 0.256 B 330 304 7 0 0 7 [[712, 970]] 1.0 8h7x TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5XGNB P00533 697 1019 1210.0 No_ligand No_ligand Inactive DFGinter 8.875 4.226 None DFGAsp-rot-out -66.63, 139.03 -107.84, 34.93 45.91, -3.75 -81.79, 142.31 255.34, 148.71 68.34, 31.51 in-in in 7.665 Saltbr-in 3.035 HRD-in -69.88, -38.92 70.25, -6.15 in-out-out SNCioo out-out ActLoopNT-out 5.544 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out 59.97, 52.07 APE9-dihe-in -79.54, 147.42 APE8-dihe-in -94.06, 88.44 APE8-rot-na 27.93 APE67-dihe-in -64.82, -35.28 -54.4, -44.67 APE12-dist-na 12.386 APE11-dist-na 15.391 APE10-dist-na 15.977 APE9-dist-na 7.966 T790M,C797S None None XRAY 3.0 0.222 0.251 B 331 308 5 0 0 4 [[712, 970]] 1.0 5xgn TYR_EGFR_HUMAN TYR 6.5e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2JITB P00533 697 1018 1210.0 No_ligand No_ligand Inactive DFGinter 8.643 4.268 None DFGAsp-rot-out -65.09, 133.17 -114.41, 36.11 63.51, -13.76 -84.27, 149.81 251.72, 154.26 60.91, 22.91 in-in in 8.03 Saltbr-in 3.164 HRD-in -71.83, -62.45 88.36, -10.04 in-out-in SNCioi out-in ActLoopNT-out 4.332 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -76.87, 136.57 APE9-dihe-in -138.24, 154.81 APE8-dihe-in -91.0, 80.78 APE8-rot-na 356.06 APE67-dihe-in -73.95, 11.71 -56.2, -43.16 APE12-dist-na 15.983 APE11-dist-na 15.773 APE10-dist-na 15.968 APE9-dist-na 7.412 T790M None None XRAY 3.1 0.209 0.249 B 327 312 0 0 0 0 [[712, 970]] 1.0 2jit TYR_EGFR_HUMAN TYR 8.3e-88 300.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2JIUB P00533 695 1004 1210.0 No_ligand No_ligand Inactive DFGinter 8.912 4.352 None DFGAsp-rot-out -62.48, 140.76 -118.63, 55.68 59.73, -12.58 -100.13, 143.92 258.8, 146.55 62.94, 28.63 in-in in 8.076 Saltbr-in 2.959 HRD-in -72.84, -64.99 94.58, -35.5 in-in-in SNCiii in-in ActLoopNT-in 3.489 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -56.69, 118.33 APE9-dihe-in -133.73, 161.67 APE8-dihe-in -92.78, 73.55 APE8-rot-na 15.24 APE67-dihe-in -66.9, -25.87 -50.11, -38.12 APE12-dist-na 16.383 APE11-dist-na 15.152 APE10-dist-na 16.405 APE9-dist-na 7.624 T790M None None XRAY 3.05 0.214 0.277 B 328 310 0 0 0 0 [[712, 970]] 1.0 2jiu TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4G5PB P00533 697 1018 1210.0 No_ligand No_ligand Inactive DFGinter 8.694 4.058 None DFGAsp-rot-out -102.27, 130.04 -119.39, 11.63 70.35, -19.05 -56.23, 139.55 268.64, 132.98 83.16, 48.09 in-in in 7.531 Saltbr-in 2.909 HRD-in -73.51, -36.65 75.01, -67.24 in-out-none SNCion out-none ActLoopNT-out 5.511 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 136.61 APE9-dihe-in -136.04, 152.17 APE8-dihe-in -101.09, 85.15 APE8-rot-na 34.16 APE67-dihe-in -61.97, -21.6 -60.83, -40.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 16.343 APE9-dist-na 8.971 T790M None None XRAY 3.17 0.247 0.323 B 330 303 8 0 0 8 [[712, 970]] 1.0 4g5p TYR_EGFR_HUMAN TYR 8.5e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3IKAB P00533 697 1017 1210.0 No_ligand No_ligand Inactive DFGinter 8.717 4.604 None DFGAsp-rot-out -75.22, 143.75 -113.63, 39.19 61.57, -14.51 -87.68, 145.68 264.7, 149.87 65.59, 19.15 in-in in 7.748 Saltbr-in 2.721 HRD-in -71.43, -56.54 82.98, -12.02 in-out-in SNCioi out-in ActLoopNT-out 5.388 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -70.44, 137.59 APE9-dihe-in -139.25, 153.6 APE8-dihe-in -85.59, 76.58 APE8-rot-na 26.0 APE67-dihe-in -74.82, -10.46 -52.9, -35.6 APE12-dist-na 16.909 APE11-dist-na 15.822 APE10-dist-na 16.726 APE9-dist-na 7.764 T790M None None XRAY 2.9 0.21 0.257 B 331 310 2 0 0 2 [[712, 970]] 1.0 3ika TYR_EGFR_HUMAN TYR 8.6e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4WD5B P00533 697 1016 1210.0 No_ligand No_ligand Inactive DFGinter 9.248 4.425 None DFGAsp-rot-out -72.57, 139.36 -100.73, 10.04 50.49, 0.82 -62.48, 143.44 260.7, 137.62 58.63, 39.1 in-out in 7.729 Saltbr-out 3.739 HRD-out -90.94, 114.01 -64.78, -40.5 out-out-in SNCooi out-in ActLoopNT-out 4.978 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -60.44, 137.91 APE9-dihe-in -137.14, 159.08 APE8-dihe-in -84.32, 85.1 APE8-rot-na 36.97 APE67-dihe-in -61.6, -40.36 -63.96, -40.18 APE12-dist-na 16.585 APE11-dist-na 15.83 APE10-dist-na 16.945 APE9-dist-na 8.836 T790M None None XRAY 3.3 0.211 0.239 B 331 304 5 0 0 5 [[712, 970]] 1.0 4wd5 TYR_EGFR_HUMAN TYR 8.6e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9U91A P00533 703 983 1210.0 A1EOG:61101 Type1 Inactive DFGinter 8.618 6.381 None DFGAsp-rot-out -69.5407, 134.9974 -109.0163, 23.0847 41.1052, -6.1685 -71.8092, 151.5532 304.8441, 101.3226 61.4913, 33.383 out-out out 10.414 Saltbr-out 5.296 HRD-out -80.5336, 124.7514 -93.4253, 8.4937 out-out-out SNCooo out-out ActLoopNT-out 5.427 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -66.7297, -40.7755 APE9-dihe-in -114.0514, 123.748 APE8-dihe-in -81.4116, 72.3693 APE8-rot-na 27.6912 APE67-dihe-in -82.6482, -15.7003 -61.9955, -21.1708 APE12-dist-na 19.048 APE11-dist-na 18.91 APE10-dist-na 17.507 APE9-dist-na 8.314 T790M,C797S,V948R None None XRAY 3.2 0.231 0.274 A 344 269 7 0 0 7 [[712, 970]] 1.0 9u91 TYR_EGFR_HUMAN TYR 1e-83 286.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5UWDA P00533 702 984 1210.0 8OV:9001 Type1 Inactive DFGinter 8.718 6.883 None DFGAsp-rot-in -103.03, 102.14 -79.54, 67.3 188.81, 27.29 -112.01, -2.59 296.52, 123.95 -53.45, -42.68 out-out out 12.173 Saltbr-out 13.169 HRD-in -62.38, -44.86 62.12, -14.75 out-out-none SNCoon out-none ActLoopNT-out 9.302 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 33.47 APE9-dihe-in -110.69, 126.69 APE8-dihe-in -92.9, 52.09 APE8-rot-na 21.1 APE67-dihe-in -67.65, -3.97 -43.65, -47.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.321 APE9-dist-na 9.235 T790M,L858R,V948R None None XRAY 3.06 0.216 0.28 A 329 271 12 0 0 12 [[712, 970]] 1.0 5uwd TYR_EGFR_HUMAN TYR 6.6e-87 297.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR IGF1R IGF1R_HUMAN 1M7NA P08069 982 1286 1367.0 No_ligand No_ligand Inactive DFGinter 8.164 7.514 None DFGAsp-rot-out -63.65, 150.56 -83.71, 161.97 55.77, -50.2 -57.58, 152.8 77.55, 99.86 65.02, 30.98 in-out in 9.867 Saltbr-out 8.828 HRD-in -83.45, -42.46 69.8, -16.63 out-out-in SNCooi out-in ActLoopNT-out 17.622 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -66.63, 113.99 APE9-dihe-in -128.05, 145.23 APE8-dihe-in -84.3, 65.47 APE8-rot-na 35.92 APE67-dihe-in -74.19, -1.69 -49.75, -32.81 APE12-dist-na 23.243 APE11-dist-na 19.123 APE10-dist-na 15.076 APE9-dist-na 7.467 None None None XRAY 2.7 0.229 0.294 A 322 299 6 0 0 0 [[999, 1268]] 1.0 1m7n TYR_IGF1R_HUMAN TYR 2.4e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 1M7NB P08069 982 1286 1367.0 No_ligand No_ligand Inactive DFGinter 9.13 7.337 None DFGAsp-rot-out -73.47, 167.84 -87.9, 168.41 38.43, -59.63 -62.8, 156.56 81.22, 124.1 55.25, 47.18 in-out in 9.829 Saltbr-out 8.107 HRD-in -100.99, -42.57 66.39, -13.05 out-out-in SNCooi out-in ActLoopNT-out 17.68 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -84.27, 123.84 APE9-dihe-in -122.55, 149.6 APE8-dihe-in -77.03, 59.62 APE8-rot-na 36.33 APE67-dihe-in -67.03, 6.96 -40.27, -45.78 APE12-dist-na 22.981 APE11-dist-na 18.942 APE10-dist-na 15.815 APE9-dist-na 7.184 None None None XRAY 2.7 0.229 0.294 B 322 299 6 0 0 0 [[999, 1268]] 1.0 1m7n TYR_IGF1R_HUMAN TYR 2.4e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 1P4OA P08069 978 1285 1367.0 No_ligand No_ligand Inactive DFGinter 8.937 7.453 None DFGAsp-rot-out -75.61, 161.81 -88.19, 167.58 49.8, -49.66 -62.75, 158.69 79.74, 92.2 58.69, 28.18 in-out in 9.669 Saltbr-out 8.161 HRD-in -85.36, -54.81 81.1, -18.95 out-out-in SNCooi out-in ActLoopNT-out 17.814 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -75.47, 124.06 APE9-dihe-in -124.38, 139.88 APE8-dihe-in -82.49, 64.57 APE8-rot-na 36.92 APE67-dihe-in -73.19, -6.91 -50.14, -35.0 APE12-dist-na 22.275 APE11-dist-na 18.248 APE10-dist-na 14.541 APE9-dist-na 7.274 E1097A,E1099A None None XRAY 1.5 0.209 0.236 A 322 308 0 0 0 0 [[999, 1268]] 1.0 1p4o TYR_IGF1R_HUMAN TYR 2.4e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 1P4OB P08069 977 1290 1367.0 No_ligand No_ligand Inactive DFGinter 8.973 7.373 None DFGAsp-rot-out -74.95, 163.69 -90.41, 168.58 49.82, -51.04 -63.57, 158.6 80.11, 88.87 59.26, 26.84 in-out in 9.712 Saltbr-out 8.134 HRD-in -85.93, -55.48 81.68, -17.46 out-out-in SNCooi out-in ActLoopNT-out 17.871 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -71.53, 126.34 APE9-dihe-in -129.41, 143.63 APE8-dihe-in -82.98, 67.29 APE8-rot-na 36.94 APE67-dihe-in -73.89, -4.17 -52.36, -34.34 APE12-dist-na 22.458 APE11-dist-na 18.39 APE10-dist-na 14.695 APE9-dist-na 7.171 E1097A,E1099A None None XRAY 1.5 0.209 0.236 B 322 314 0 0 0 0 [[999, 1268]] 1.0 1p4o TYR_IGF1R_HUMAN TYR 2.4e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR KDR VGFR2_HUMAN 1Y6AA P35968 820 1167 1356.0 AAZ:60201 Type1 Inactive DFGinter 8.666 8.838 None DFGAsp-rot-out -73.14, 116.72 -103.71, 73.1 344.12, -68.77 -178.89, 999.0 25.84, 61.42 999.0, 999.0 in-in in 7.47 Saltbr-in 2.801 HRD-in -83.04, -53.13 81.96, -16.64 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -20.95 APE8-rot-na 328.99 APE67-dihe-in -63.85, -16.51 -63.27, -26.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.1 0.196 0.217 A 366 261 87 0 0 20 [[834, 1162]] 1.0 1y6a TYR_KDR_HUMAN TYR 2.7e-99 337.7 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
TYR KDR VGFR2_HUMAN 1Y6BA P35968 819 1168 1356.0 AAX:60201 Type1 Inactive DFGinter 8.959 8.691 None DFGAsp-rot-out -70.35, 112.74 -90.68, -29.02 38.74, -15.31 -42.32, 999.0 351.89, 106.67 999.0, 999.0 in-in in 7.482 Saltbr-in 2.957 HRD-in -82.96, -58.21 87.46, -12.31 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 69.65 APE8-rot-na 33.76 APE67-dihe-in -65.54, -15.03 -63.36, -37.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.1 0.194 0.236 A 366 266 84 0 0 20 [[834, 1162]] 1.0 1y6b TYR_KDR_HUMAN TYR 2.7e-99 337.7 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
TYR PTK2 FAK1_HUMAN 4EBWA Q05397 411 686 1052.0 0PF:700 Type1 Inactive DFGinter 10.52 8.023 None DFGAsp-rot-out -156.77, 167.19 -119.55, 38.35 51.17, 5.91 -154.8, 160.1 57.14, 97.67 -105.09, 155.15 in-in in 7.232 Saltbr-in 3.021 HRD-out -85.85, 108.83 -92.42, -13.42 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 105.2 APE9-dihe-in -103.42, 143.85 APE8-dihe-in -74.96, 72.04 APE8-rot-na 29.05 APE67-dihe-in -70.29, -24.24 -52.29, -39.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 17.857 APE9-dist-na 9.391 None None None XRAY 2.65 0.186 0.273 A 304 259 17 0 0 15 [[422, 678]] 1.0 4ebw TYR_PTK2_HUMAN TYR 4.8e-93 317.2 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR ROR2 ROR2_HUMAN 3ZZWA Q01974 466 750 943.0 No_ligand No_ligand Pseudo DFGinter 10.345 8.07 None DFGAsp-rot-in -96.3, 113.42 -93.32, 36.02 210.77, -34.5 -147.08, 160.59 50.4, 103.61 174.45, -162.31 in-out in 8.469 Saltbr-out 4.596 HRD-in -47.14, -51.88 77.11, -23.02 out-out-in SNCooi out-in ActLoopNT-out 17.444 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -102.81, 114.23 APE9-dihe-in -109.27, 120.13 APE8-dihe-in -82.4, 68.78 APE8-rot-na 28.79 APE67-dihe-in -64.86, -16.77 -44.26, -50.32 APE12-dist-na 13.627 APE11-dist-na 12.242 APE10-dist-na 7.628 APE9-dist-na 7.665 None None None XRAY 2.9 0.19 0.247 A 289 269 16 0 0 0 [[473, 748]] 1.0 3zzw TYR_ROR2_HUMAN TYR 5.5e-91 310.4 2 260 259 632 633 634 636 638 507 524 528 612 614 613 615 674 662 657 656 655 654 653 652 651 554 Tyrosine-protein kinase transmembrane receptor ROR2
TYR ROR2 ROR2_HUMAN 4GT4A Q01974 464 751 943.0 No_ligand No_ligand Pseudo DFGinter 9.614 6.483 None DFGAsp-rot-out -93.67, 118.8 -119.64, 62.63 52.73, 0.13 -106.27, -3.3 278.25, 67.29 61.48, 39.98 in-out in 8.533 Saltbr-out 3.871 HRD-out -75.16, 142.52 -112.65, 2.81 out-out-in SNCooi out-in ActLoopNT-out 16.314 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -79.46, 127.32 APE9-dihe-in -119.05, 136.77 APE8-dihe-in -80.2, 67.59 APE8-rot-na 30.63 APE67-dihe-in -67.7, -19.84 -54.55, -34.96 APE12-dist-na 15.894 APE11-dist-na 12.718 APE10-dist-na 10.239 APE9-dist-na 6.747 None None None XRAY 2.406 0.179 0.205 A 308 274 14 0 0 0 [[473, 748]] 1.0 4gt4 TYR_ROR2_HUMAN TYR 6.9e-91 310.1 2 260 259 632 633 634 636 638 507 524 528 612 614 613 615 674 662 657 656 655 654 653 652 651 554 Tyrosine-protein kinase transmembrane receptor ROR2
TYR ROR2 ROR2_HUMAN 4GT4B Q01974 464 752 943.0 No_ligand No_ligand Pseudo DFGinter 10.193 7.582 None DFGAsp-rot-none -91.01, 100.94 -99.91, 70.26 999.0, 999.0 -110.46, -11.91 297.81, 174.51 61.14, 43.64 in-in in 8.881 Saltbr-in 2.975 HRD-in -71.57, -49.3 78.13, -12.79 in-out-in SNCioi out-in ActLoopNT-out 16.141 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -85.88, 120.55 APE9-dihe-in -112.46, 137.59 APE8-dihe-in -79.18, 69.28 APE8-rot-na 29.96 APE67-dihe-in -69.15, -20.22 -53.97, -34.39 APE12-dist-na 15.711 APE11-dist-na 12.448 APE10-dist-na 10.062 APE9-dist-na 6.755 None None None XRAY 2.406 0.179 0.205 B 308 273 16 0 0 0 [[473, 748]] 1.0 4gt4 TYR_ROR2_HUMAN TYR 6.9e-91 310.1 2 260 259 632 633 634 636 638 507 524 528 612 614 613 615 674 662 657 656 655 654 653 652 651 554 Tyrosine-protein kinase transmembrane receptor ROR2
TYR SRC SRC_HUMAN 4MXXB P12931 261 536 536.0 DB8:60601 Type1 Inactive DFGinter 9.192 8.286 BABtrans DFGAsp-rot-out -85.22, 126.66 -111.4, 38.55 50.12, -35.74 -113.28, 121.97 179.79, 84.82 122.67, -27.99 out-out out 10.737 Saltbr-out 7.312 HRD-in -99.39, -46.07 76.64, -21.16 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 94.26 APE8-dihe-in -50.75, 100.65 APE8-rot-na 26.17 APE67-dihe-in -61.28, -28.71 -44.67, -43.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 5.954 A406T None None XRAY 2.6 0.213 0.276 B 286 260 16 0 0 16 [[270, 521]] 1.0 4mxx TYR_SRC_HUMAN TYR 3.2e-94 321.0 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR TEK TIE2_HUMAN 1FVRA Q02763 813 1121 1124.0 No_ligand No_ligand Inactive DFGinter 8.417 7.259 BABtrans DFGAsp-rot-out -70.32, 127.73 -127.01, 36.72 47.31, 12.52 -94.99, 138.29 184.97, 79.8 67.05, 29.11 out-out out 10.373 Saltbr-out 7.44 HRD-in -69.68, -50.63 81.63, -26.26 out-out-none SNCoon out-none ActLoopNT-out 5.117 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.88 APE8-dihe-in -75.53, 55.91 APE8-rot-na 38.59 APE67-dihe-in -71.29, -9.41 -46.42, -37.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.515 None None None XRAY 2.2 0.195 0.225 A 327 299 10 0 0 4 [[824, 1094]] 1.0 1fvr TYR_TEK_HUMAN TYR 8.6e-91 309.8 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
TYR TEK TIE2_HUMAN 1FVRB Q02763 813 1121 1124.0 No_ligand No_ligand Inactive DFGinter 8.59 7.184 BABtrans DFGAsp-rot-out -71.55, 125.08 -125.14, 43.48 47.62, 14.48 -101.19, 137.55 183.68, 81.8 68.42, 28.27 out-out out 10.101 Saltbr-out 7.6 HRD-in -66.4, -52.26 80.81, -19.06 out-out-none SNCoon out-none ActLoopNT-out 5.131 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, -27.62 APE9-dihe-in -107.96, 129.21 APE8-dihe-in -75.73, 57.96 APE8-rot-na 37.26 APE67-dihe-in -64.73, -13.95 -46.88, -41.75 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 17.261 APE9-dist-na 8.643 None None None XRAY 2.2 0.195 0.225 B 327 300 9 0 0 3 [[824, 1094]] 1.0 1fvr TYR_TEK_HUMAN TYR 8.6e-91 309.8 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor

All / DFGinter / All

Total number of chains: 258
Active chains: 0
Total number of genes: 53
Spatial label Dihedral label Number of Chains Percent Representative
DFGinter None 232 89.9% 4U3YA
DFGinter BABtrans 26 10.1% 7YC9A
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Asp
χ1,χ2		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK SRK2E SRK2E_ARATH 3UJGA Q940H6 20 318 362.0 No_ligand No_ligand Inactive DFGinter 7.568 7.802 None DFGAsp-rot-in 59.82, 78.75 -91.25, 162.66 201.18, -10.33 -45.68, -61.55 178.96, 56.58 -72.38, 37.27 out-out out 11.43 Saltbr-out 9.739 HRD-out 55.1, -126.57 -66.01, -15.12 out-out-out SNCooo out-out ActLoopNT-out 7.216 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -64.04, 142.08 APE9-dihe-na -75.28, -60.65 APE8-dihe-in -122.16, 75.37 APE8-rot-in 331.63 APE67-dihe-in -49.71, -30.19 -60.02, -24.28 APE12-dist-out 19.771 APE11-dist-out 19.693 APE10-dist-out 15.721 APE9-dist-out 14.72 D296A,E297A None None XRAY 2.6 0.209 0.238 A 361 290 5 0 0 0 [[21, 277]] 1.0 3ujg Arabidopsis thaliana CAMK_SRK2E_ARATH CAMK 2.4e-79 272.4 1 256 256 159 160 161 163 165 50 65 69 137 139 138 140 199 186 181 180 179 178 177 176 175 95 Serine/threonine-protein kinase SRK2E
CAMK SRK2E SRK2E_ARATH 3UDBA Q940H6 12 317 362.0 No_ligand No_ligand Inactive DFGinter 8.946 9.963 None DFGAsp-rot-in -96.71, 98.33 -99.5, 64.58 223.98, -38.79 -98.76, 177.69 315.85, 158.5 -146.95, -61.19 out-out out 10.482 Saltbr-out 8.442 HRD-out 65.08, 72.38 -56.81, -178.3 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 176.26 APE8-rot-out 78.91 APE67-dihe-in -55.61, -35.04 -55.27, -18.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S7A,S29A,S43A,C131A,C137A,C159A,S166A,T176A None None XRAY 2.567 0.238 0.259 A 317 275 15 0 0 15 [[21, 277]] 1.0 3udb Arabidopsis thaliana CAMK_SRK2E_ARATH CAMK 3.1e-77 265.4 1 256 256 159 160 161 163 165 50 65 69 137 139 138 140 199 186 181 180 179 178 177 176 175 95 Serine/threonine-protein kinase SRK2E
CAMK SRK2E SRK2E_ARATH 3UDBB Q940H6 12 317 362.0 No_ligand No_ligand Inactive DFGinter 9.458 9.004 None DFGAsp-rot-in -107.79, 64.97 -84.29, 91.48 188.21, 4.1 178.09, 129.52 67.29, 76.65 -128.86, 102.63 out-out out 10.315 Saltbr-out 9.084 HRD-out -47.3, 135.95 -119.13, -152.23 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 171.81 APE8-dihe-in -129.32, 159.05 APE8-rot-out 145.59 APE67-dihe-in -68.82, -38.77 -105.83, 9.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 15.484 S7A,S29A,S43A,C131A,C137A,C159A,S166A,T176A None None XRAY 2.567 0.238 0.259 B 317 278 14 0 0 14 [[21, 277]] 1.0 3udb Arabidopsis thaliana CAMK_SRK2E_ARATH CAMK 3.1e-77 265.4 1 256 256 159 160 161 163 165 50 65 69 137 139 138 140 199 186 181 180 179 178 177 176 175 95 Serine/threonine-protein kinase SRK2E
CAMK SRK2E SRK2E_ARATH 3UDBD Q940H6 12 317 362.0 No_ligand No_ligand Inactive DFGinter 9.791 9.667 None DFGAsp-rot-in -91.8, 111.78 -135.53, 46.38 223.25, -41.84 -101.81, -90.87 27.7, 109.09 154.77, -129.77 out-out out 10.345 Saltbr-out 9.362 HRD-out -58.99, 138.62 -118.26, 126.91 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 144.66 APE8-rot-out 79.39 APE67-dihe-in -35.53, -45.05 -73.71, -21.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S7A,S29A,S43A,C131A,C137A,C159A,S166A,T176A None None XRAY 2.567 0.238 0.259 D 317 279 15 0 0 15 [[21, 277]] 1.0 3udb Arabidopsis thaliana CAMK_SRK2E_ARATH CAMK 3.1e-77 265.4 1 256 256 159 160 161 163 165 50 65 69 137 139 138 140 199 186 181 180 179 178 177 176 175 95 Serine/threonine-protein kinase SRK2E
CAMK SRK2E SRK2E_ARATH 3UDBF Q940H6 12 317 362.0 No_ligand No_ligand Inactive DFGinter 9.606 8.997 None DFGAsp-rot-in -89.63, 118.14 -143.13, 62.81 203.55, 16.18 -97.7, -94.26 311.41, 167.87 124.81, -154.36 out-out out 10.468 Saltbr-out 9.53 HRD-out -149.35, 103.88 -79.53, -161.56 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 155.59 APE8-rot-out 148.18 APE67-dihe-in -48.65, -38.94 -78.23, -15.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S7A,S29A,S43A,C131A,C137A,C159A,S166A,T176A None None XRAY 2.567 0.238 0.259 F 317 273 15 0 0 15 [[21, 277]] 1.0 3udb Arabidopsis thaliana CAMK_SRK2E_ARATH CAMK 3.1e-77 265.4 1 256 256 159 160 161 163 165 50 65 69 137 139 138 140 199 186 181 180 179 178 177 176 175 95 Serine/threonine-protein kinase SRK2E
CAMK SRK2E SRK2E_ARATH 3UC4A Q940H6 12 318 362.0 No_ligand No_ligand Inactive DFGinter 10.419 8.803 None DFGAsp-rot-out -97.83, 106.12 -111.34, 79.34 314.8, 47.7 -172.98, -178.43 64.01, 91.63 172.73, 93.4 out-out out 10.993 Saltbr-out 9.773 HRD-out -94.45, -144.27 57.85, 64.78 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioo APE10-dihe-na -55.05, 149.11 APE9-dihe-na -108.74, -144.63 APE8-dihe-in -66.94, 137.61 APE8-rot-in 311.07 APE67-dihe-in -51.84, -39.21 -67.86, -12.89 APE12-dist-none 999.0 APE11-dist-in 13.889 APE10-dist-out 16.606 APE9-dist-out 15.591 D59A,E60A None None XRAY 2.3 0.223 0.246 A 362 295 12 0 0 12 [[21, 277]] 1.0 3uc4 Arabidopsis thaliana CAMK_SRK2E_ARATH CAMK 5.3e-79 271.2 1 256 256 159 160 161 163 165 50 65 69 137 139 138 140 199 186 181 180 179 178 177 176 175 95 Serine/threonine-protein kinase SRK2E
CAMK SRK2E SRK2E_ARATH 3UC4B Q940H6 12 317 362.0 No_ligand No_ligand Inactive DFGinter 9.763 9.844 None DFGAsp-rot-in -87.79, 109.76 -113.77, 77.45 191.58, -61.38 -112.94, -178.18 314.75, 135.71 -167.77, 42.25 out-out out 10.656 Saltbr-out 11.458 HRD-out -49.56, 113.93 -99.19, 165.37 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -81.5, 146.08 APE9-dihe-na -145.54, 122.05 APE8-dihe-in -91.29, 141.51 APE8-rot-out 164.59 APE67-dihe-in -51.35, -36.1 -66.05, -10.11 APE12-dist-out 17.154 APE11-dist-out 14.536 APE10-dist-out 20.449 APE9-dist-out 15.513 D59A,E60A None None XRAY 2.3 0.223 0.246 B 362 277 11 0 0 11 [[21, 277]] 1.0 3uc4 Arabidopsis thaliana CAMK_SRK2E_ARATH CAMK 5.3e-79 271.2 1 256 256 159 160 161 163 165 50 65 69 137 139 138 140 199 186 181 180 179 178 177 176 175 95 Serine/threonine-protein kinase SRK2E
AGC GRK1 GRK1_BOVIN 3C4YB P28327 30 532 561.0 No_ligand No_ligand Inactive DFGinter 8.04 10.553 None DFGAsp-rot-in -138.64, 168.89 59.27, 104.12 204.97, 48.94 -125.95, 37.77 308.57, 133.4 -61.52, -52.16 in-out in 9.832 Saltbr-out 4.417 HRD-in -105.99, -36.37 67.54, -61.73 out-in-in SNCoii in-in ActLoopNT-in 3.206 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -178.33, 157.76 APE9-dihe-na 144.04, -133.41 APE8-dihe-in -135.26, 121.19 APE8-rot-in 303.52 APE67-dihe-inflip 122.3, -40.41 -49.79, 107.51 APE12-dist-in 11.426 APE11-dist-in 12.656 APE10-dist-in 7.632 APE9-dist-in 5.789 None None None XRAY 7.509 0.182 999.0 B 543 466 8 0 0 0 [[187, 452]] 1.0 3c4y Bos taurus AGC_GRK1_BOVIN AGC 3.2e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
OTHER PKNG Q8NM29_CORGL 7MXJA Q8NM29 62 358 751.0 MAP:60502 Type1 Inactive DFGinter 6.293 10.601 None DFGAsp-rot-in -111.55, -5.33 -97.65, 70.49 198.93, -1.99 -64.68, -29.22 283.51, 177.78 -64.44, -22.13 out-out out 15.695 Saltbr-out 15.021 HRD-in -87.66, -33.88 74.73, -35.65 out-in-out SNCoio in-out ActLoopNT-in 2.848 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -89.56, 75.8 APE9-dihe-na -90.07, -165.64 APE8-dihe-in -127.82, 123.34 APE8-rot-in 300.01 APE67-dihe-inflip 102.34, -29.53 -61.55, 136.0 APE12-dist-in 10.93 APE11-dist-out 7.83 APE10-dist-in 5.018 APE9-dist-in 3.78 None None None XRAY 1.92 0.2 0.225 A 305 285 5 0 0 0 [[104, 300]] 1.0 7mxj Corynebacterium glutamicum OTHER_PKNG_CORGL CAMK 7.6e-21 80.7 1 186 186 246 247 248 250 252 134 151 155 227 229 228 230 281 270 265 264 263 262 261 260 259 183 non-specific serine/threonine protein kinase
OTHER PKNG Q8NM29_CORGL 7MXKA Q8NM29 63 360 751.0 MAP:60502 Type1 Inactive DFGinter 6.194 10.434 None DFGAsp-rot-in -118.18, -5.51 -93.88, 67.71 200.06, -5.73 -62.41, -37.49 263.51, 7.21 -64.54, -17.14 out-out out 15.739 Saltbr-out 15.548 HRD-in -82.84, -35.3 75.7, -37.3 out-in-out SNCoio in-out ActLoopNT-in 2.839 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -89.12, 60.2 APE9-dihe-na -82.13, -171.26 APE8-dihe-in -126.78, 123.26 APE8-rot-in 300.71 APE67-dihe-inflip 98.87, -23.41 -59.19, 137.58 APE12-dist-in 10.703 APE11-dist-out 7.784 APE10-dist-in 5.009 APE9-dist-in 3.749 None None None XRAY 1.99 0.21 0.237 A 305 292 6 0 0 0 [[104, 300]] 1.0 7mxk Corynebacterium glutamicum OTHER_PKNG_CORGL CAMK 7.6e-21 80.7 1 186 186 246 247 248 250 252 134 151 155 227 229 228 230 281 270 265 264 263 262 261 260 259 183 non-specific serine/threonine protein kinase
OTHER PKNG Q8NM29_CORGL 7MXBB Q8NM29 54 727 751.0 MAP:60901 Type1 Inactive DFGinter 5.205 10.811 None DFGAsp-rot-in -117.76, -14.76 -88.45, 66.45 201.61, -5.37 -66.91, -35.42 188.49, 46.74 -64.23, -11.33 out-out out 16.485 Saltbr-out 17.106 HRD-in -84.45, -36.61 76.45, -45.49 out-in-in SNCoii in-in ActLoopNT-in 2.774 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -79.04, -21.26 APE9-dihe-na -81.14, -177.06 APE8-dihe-in -127.04, 126.21 APE8-rot-in 302.13 APE67-dihe-inflip 106.12, -20.6 -59.76, 129.82 APE12-dist-in 11.141 APE11-dist-in 9.35 APE10-dist-in 4.109 APE9-dist-in 3.755 None None None XRAY 2.2 0.211 0.246 B 700 655 8 0 0 0 [[104, 300]] 1.0 7mxb Corynebacterium glutamicum OTHER_PKNG_CORGL CAMK 5e-20 78.5 1 186 186 246 247 248 250 252 134 151 155 227 229 228 230 281 270 265 264 263 262 261 260 259 183 non-specific serine/threonine protein kinase
TYR SRC SRC_CHICK 2QQ7B P00523 258 533 533.0 SR2:1345 Type1 Inactive DFGinter 9.517 7.614 None DFGAsp-rot-out -107.97, -176.31 -160.38, -10.12 75.27, -46.14 -153.22, -18.85 328.02, 74.39 140.07, -38.97 none-none none 999.0 Saltbr-none 999.0 HRD-in -84.14, -56.03 85.98, -16.08 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 53.57 APE8-rot-na 13.57 APE67-dihe-in -68.8, -27.47 -72.76, -15.15 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 T338M,S345C None None XRAY 2.38 0.217 0.266 B 286 244 32 0 0 17 [[267, 518]] 1.0 2qq7 Gallus gallus TYR_SRC_CHICK TYR 3.5e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3LOKB P00523 258 533 533.0 DJK:1345 Type1 Inactive DFGinter 8.998 7.343 None DFGAsp-rot-out -159.95, 165.79 -130.83, 138.21 36.19, -34.37 -129.88, -38.43 343.22, 92.96 171.11, -62.33 none-none none 999.0 Saltbr-none 999.0 HRD-in -82.23, -48.63 85.47, -21.61 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -14.67 APE8-rot-na 348.92 APE67-dihe-in -76.3, -19.85 -81.25, -4.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 T338M,S345C None None XRAY 2.48 0.225 0.286 B 286 242 34 0 0 17 [[267, 518]] 1.0 3lok Gallus gallus TYR_SRC_CHICK TYR 3.5e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
AGC ROCK1 ROCK1_HUMAN 3TWJB Q13464 8 402 1354.0 No_ligand No_ligand Inactive DFGinter 10.815 7.295 None DFGAsp-rot-in -140.02, 177.72 -138.03, 117.9 222.7, -23.05 -134.18, -179.7 267.51, 14.98 -75.11, 143.68 in-in in 8.042 Saltbr-in 3.562 HRD-in -70.23, -44.84 80.45, -14.54 in-out-out SNCioo out-out ActLoopNT-out 20.375 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -116.17, 145.08 APE9-dihe-na 57.93, -141.29 APE8-dihe-in -142.15, 148.38 APE8-rot-out 101.8 APE67-dihe-in -61.61, -39.57 -51.91, -51.11 APE12-dist-in 11.787 APE11-dist-in 13.034 APE10-dist-out 12.316 APE9-dist-in 4.196 None None None XRAY 2.9 0.224 0.289 B 410 395 0 0 0 0 [[76, 338]] 1.0 3twj Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC ROCK1 ROCK1_HUMAN 3TWJD Q13464 8 402 1354.0 No_ligand No_ligand Inactive DFGinter 10.79 6.927 None DFGAsp-rot-in -126.16, 176.03 -134.68, 123.87 202.81, -39.78 -143.34, -165.47 284.96, 15.3 -95.64, -168.75 in-in in 8.257 Saltbr-in 2.943 HRD-in -49.62, -47.32 79.16, -22.55 in-out-out SNCioo out-out ActLoopNT-out 20.397 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na 45.48, 65.51 APE9-dihe-na 78.31, -176.86 APE8-dihe-in -88.74, 143.63 APE8-rot-out 17.15 APE67-dihe-in -61.11, -33.54 -55.29, -47.59 APE12-dist-in 9.993 APE11-dist-in 10.777 APE10-dist-out 10.945 APE9-dist-in 5.297 None None None XRAY 2.9 0.224 0.289 D 410 395 0 0 0 0 [[76, 338]] 1.0 3twj Homo sapiens AGC_ROCK1_HUMAN AGC 3.5e-94 320.8 1 260 260 215 216 217 219 221 105 124 128 195 197 196 198 260 244 239 238 237 236 235 234 233 154 Rho-associated protein kinase 1
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOC P51812 46 347 740.0 ANP:401 ATPlike Inactive DFGinter 5.815 10.993 None DFGAsp-rot-in -75.13, -10.43 -146.35, 169.25 199.75, -26.56 -135.79, 44.23 43.29, 81.79 87.07, 14.29 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.74, -32.6 74.07, -63.87 none-out-out SNCnoo out-out ActLoopNT-out 10.165 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -61.13, 122.89 APE9-dihe-na 75.62, 166.95 APE8-dihe-in -113.03, 115.92 APE8-rot-out 46.3 APE67-dihe-in -62.7, -36.2 -57.15, -32.55 APE12-dist-out 16.312 APE11-dist-out 16.934 APE10-dist-out 13.494 APE9-dist-out 6.87 None None None XRAY 2.75 0.209 0.232 C 317 295 7 0 0 0 [[68, 327], [422, 679]] 2.0 7opo Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA3-1 KS6A3_HUMAN 7OPOG P51812 46 348 740.0 ANP:401 ATPlike Inactive DFGinter 6.68 10.963 None DFGAsp-rot-in -75.68, -10.29 -146.32, 168.68 199.8, -24.84 -137.91, 45.72 44.25, 84.07 86.95, 15.93 out-out out 19.338 Saltbr-out 19.753 HRD-in -66.3, -31.74 74.35, -64.56 out-out-out SNCooo out-out ActLoopNT-out 10.112 ActLoopCT-out nonTYR APEdihe_aanni APEdist_oonn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 105.02 APE8-rot-none 999.0 APE67-dihe-in -58.75, -33.49 -86.55, -15.46 APE12-dist-out 16.986 APE11-dist-out 17.767 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.209 0.232 G 317 301 2 0 0 2 [[68, 327], [422, 679]] 2.0 7opo Homo sapiens AGC_RPS6KA3-1_HUMAN AGC 2.5e-97 331.0 1 260 260 210 211 212 214 216 100 118 122 190 192 191 193 250 238 233 232 231 230 229 228 227 148 Ribosomal protein S6 kinase alpha-3
AGC RPS6KA5-1 KS6A5_HUMAN 1VZOA O75582 24 345 802.0 No_ligand No_ligand Inactive DFGinter 7.012 10.857 None DFGAsp-rot-out -86.08, 7.16 -135.82, 179.44 269.56, -63.77 -156.19, 30.86 46.84, 81.68 100.81, 7.87 out-out out 18.111 Saltbr-out 19.343 HRD-in -69.35, -43.67 69.6, -31.81 out-out-out SNCooo out-out ActLoopNT-out 10.263 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooo APE10-dihe-na -83.3, -23.05 APE9-dihe-na -99.28, -166.51 APE8-dihe-in -67.08, 145.98 APE8-rot-out 174.8 APE67-dihe-in -63.46, -19.35 -108.6, 7.57 APE12-dist-in 13.98 APE11-dist-out 18.829 APE10-dist-out 17.834 APE9-dist-out 11.153 S212D None None XRAY 1.8 0.208 0.242 A 355 319 3 0 0 0 [[49, 318], [423, 687]] 2.0 1vzo Homo sapiens AGC_RPS6KA5-1_HUMAN AGC 7.3e-93 316.4 1 260 260 194 195 196 198 200 81 101 105 174 176 175 177 237 223 218 217 216 215 214 213 212 132 Ribosomal protein S6 kinase alpha-5
AGC RPS6KA6-1 KS6A6_HUMAN 6G76B Q9UK32 51 349 745.0 ANP:401 ATPlike Inactive DFGinter 5.797 10.982 None DFGAsp-rot-in -66.14, -24.76 -146.8, 171.15 184.14, 24.57 -130.39, 64.5 31.65, 91.02 69.21, 34.12 none-none none 999.0 Saltbr-none 999.0 HRD-in -64.7, -28.83 65.1, -58.97 none-out-none SNCnon out-none ActLoopNT-out 9.714 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -65.75, -19.3 999.0, -17.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None SEP232 SEP232 XRAY 3.0 0.226 0.268 B 307 269 30 0 0 11 [[73, 330], [426, 683]] 2.0 6g76 Homo sapiens AGC_RPS6KA6-1_HUMAN AGC 1.2e-97 332.1 1 260 260 215 216 217 219 221 105 123 127 195 197 196 198 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G78A Q9UK32 51 349 745.0 ANP:401 ATPlike Inactive DFGinter 6.269 10.634 None DFGAsp-rot-in -86.41, -10.47 -141.48, -170.45 212.36, -52.29 -156.88, 52.15 42.27, 88.32 84.48, 16.59 none-none none 999.0 Saltbr-none 999.0 HRD-in -69.26, -28.88 63.94, -61.25 none-out-out SNCnoo out-out ActLoopNT-out 9.59 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 82.23 APE8-dihe-out 57.69, 79.35 APE8-rot-in 324.77 APE67-dihe-in -47.93, -24.91 -65.59, -33.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 7.912 S232E None None XRAY 2.5 0.227 0.24 A 307 283 16 0 0 8 [[73, 330], [426, 683]] 2.0 6g78 Homo sapiens AGC_RPS6KA6-1_HUMAN AGC 1.4e-97 331.8 1 260 260 215 216 217 219 221 105 123 127 195 197 196 198 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G78B Q9UK32 51 349 745.0 ANP:401 ATPlike Inactive DFGinter 5.64 10.738 None DFGAsp-rot-in -79.92, -10.17 -139.49, -179.53 209.54, -48.65 -146.16, 53.91 40.8, 75.5 84.23, 17.04 none-none none 999.0 Saltbr-none 999.0 HRD-in -71.51, -26.87 55.09, -79.87 none-out-out SNCnoo out-out ActLoopNT-out 9.839 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -162.93 APE8-dihe-in -60.6, 118.59 APE8-rot-in 321.37 APE67-dihe-in -66.02, -21.47 -64.56, -33.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 6.845 S232E None None XRAY 2.5 0.227 0.24 B 307 281 18 0 0 10 [[73, 330], [426, 683]] 2.0 6g78 Homo sapiens AGC_RPS6KA6-1_HUMAN AGC 1.4e-97 331.8 1 260 260 215 216 217 219 221 105 123 127 195 197 196 198 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC RPS6KA6-1 KS6A6_HUMAN 6G76A Q9UK32 51 349 745.0 ANP:401,ANP:402 ATPlike,Allosteric Inactive DFGinter 6.261 10.877 None DFGAsp-rot-in -85.39, -13.66 -143.61, 178.12 202.81, -28.93 -143.21, 50.96 33.86, 88.85 75.03, 27.38 none-none none 999.0 Saltbr-none 999.0 HRD-in -70.26, -5.92 45.43, -59.01 none-out-out SNCnoo out-out ActLoopNT-out 9.842 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na 52.64, -135.92 APE9-dihe-na -103.88, -148.96 APE8-dihe-in -100.12, 127.8 APE8-rot-in 306.8 APE67-dihe-in -56.57, -28.02 -70.04, -37.97 APE12-dist-in 13.909 APE11-dist-out 16.247 APE10-dist-out 12.746 APE9-dist-in 5.596 None SEP232 SEP232 XRAY 3.0 0.226 0.268 A 307 291 8 0 0 0 [[73, 330], [426, 683]] 2.0 6g76 Homo sapiens AGC_RPS6KA6-1_HUMAN AGC 1.2e-97 332.1 1 260 260 215 216 217 219 221 105 123 127 195 197 196 198 255 243 238 237 236 235 234 233 232 153 Ribosomal protein S6 kinase alpha-6
AGC SGK1 SGK1_HUMAN 2R5TA O00141 82 378 431.0 ANP:500 ATPlike Inactive DFGinter 10.249 5.74 None DFGAsp-rot-in -86.79, -16.14 -72.2, 135.26 187.88, -80.22 -125.95, 20.0 58.26, 94.07 102.37, 6.12 none-none none 999.0 Saltbr-none 999.0 HRD-in -67.44, -44.78 83.3, -51.0 none-out-out SNCnoo out-out ActLoopNT-out 9.243 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na 54.74, 50.94 APE9-dihe-na -69.27, 152.13 APE8-dihe-in -51.76, 128.99 APE8-rot-in 305.39 APE67-dihe-out -166.98, 160.95 -53.6, 132.16 APE12-dist-out 29.883 APE11-dist-out 30.65 APE10-dist-out 28.034 APE9-dist-out 16.248 S74A,S78A,S397A,S401A None None XRAY 1.9 0.193 0.215 A 373 284 13 0 0 0 [[98, 355]] 1.0 2r5t Homo sapiens AGC_SGK1_HUMAN AGC 4.7e-99 336.7 1 260 260 239 240 241 243 245 127 146 150 219 221 220 222 279 267 262 261 260 259 258 257 256 177 Serine/threonine-protein kinase Sgk1
AGC SGK1 SGK1_HUMAN 3HDMA O00141 81 378 431.0 MMG:500 Type1 Inactive DFGinter 9.977 5.743 None DFGAsp-rot-in -83.68, -7.68 -69.69, 128.31 171.02, 79.94 -122.03, 7.18 59.85, 94.45 118.71, -0.25 none-none none 999.0 Saltbr-none 999.0 HRD-in -68.93, -38.18 84.66, -53.42 none-out-out SNCnoo out-out ActLoopNT-out 7.78 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na 56.48, 64.87 APE9-dihe-na -77.63, -170.21 APE8-dihe-in -69.51, 134.86 APE8-rot-in 310.86 APE67-dihe-out -140.61, 157.94 -65.57, 107.15 APE12-dist-out 30.439 APE11-dist-out 31.121 APE10-dist-out 28.385 APE9-dist-out 16.422 S74A,S78A,S397A,S401A None None XRAY 2.6 0.22 0.262 A 373 285 13 0 0 0 [[98, 355]] 1.0 3hdm Homo sapiens AGC_SGK1_HUMAN AGC 4.7e-99 336.7 1 260 260 239 240 241 243 245 127 146 150 219 221 220 222 279 267 262 261 260 259 258 257 256 177 Serine/threonine-protein kinase Sgk1
AGC SGK1 SGK1_HUMAN 3HDNA O00141 82 374 431.0 GMG:1 Type1 Inactive DFGinter 10.684 6.059 None DFGAsp-rot-in -80.54, -17.07 -64.88, 127.58 192.2, -65.6 -123.29, -5.01 55.66, 91.25 125.69, 15.03 none-none none 999.0 Saltbr-none 999.0 HRD-in -68.11, -29.45 73.47, -60.84 none-out-out SNCnoo out-out ActLoopNT-out 8.284 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na 56.04, 66.32 APE9-dihe-na -71.14, 173.43 APE8-dihe-in -68.52, 127.58 APE8-rot-in 307.02 APE67-dihe-out -159.22, 150.57 -56.04, 117.71 APE12-dist-out 30.099 APE11-dist-out 30.865 APE10-dist-out 28.034 APE9-dist-out 16.482 S74A,S78A,S397A,S401A None None XRAY 3.1 0.251 0.278 A 373 280 13 0 0 0 [[98, 355]] 1.0 3hdn Homo sapiens AGC_SGK1_HUMAN AGC 4.7e-99 336.7 1 260 260 239 240 241 243 245 127 146 150 219 221 220 222 279 267 262 261 260 259 258 257 256 177 Serine/threonine-protein kinase Sgk1
CAMK AURKA AURKA_HUMAN 4C3RA O14965 127 388 403.0 ACP:1389 ATPlike Inactive DFGinter 6.087 8.639 None DFGAsp-rot-out -114.31, -7.36 -87.64, 130.6 111.26, 78.11 -72.8, -47.16 285.43, 29.08 69.28, 138.63 out-out out 11.963 Saltbr-out 7.785 HRD-out -148.79, 112.09 -68.12, -80.01 out-out-out SNCooo out-out ActLoopNT-out 8.017 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 137.49 APE8-dihe-in -74.84, 138.8 APE8-rot-out 199.32 APE67-dihe-in -50.64, -36.72 -89.13, -8.42 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 10.231 None None None XRAY 2.79 0.229 0.306 A 282 252 10 0 0 10 [[133, 383]] 1.0 4c3r Homo sapiens CAMK_AURKA_HUMAN CAMK 7.6e-80 273.9 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6C83B O14965 127 388 403.0 ACP:501 ATPlike Inactive DFGinter 7.317 8.588 None DFGAsp-rot-in -129.69, 90.85 -100.04, 101.37 198.57, -2.88 -135.34, 999.0 303.1, 99.49 999.0, 999.0 out-out out 12.115 Saltbr-out 10.049 HRD-out -96.09, 116.19 -110.78, 111.97 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -90.23 APE8-dihe-out -77.58, -0.58 APE8-rot-out 85.03 APE67-dihe-in -69.49, -5.14 -61.84, -44.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.472 None None None XRAY 2.55 0.268 0.322 B 285 247 15 0 0 15 [[133, 383]] 1.0 6c83 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.9e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5L8JA O14965 126 391 403.0 ADP:60501 ATPlike Inactive DFGinter 6.039 8.812 None DFGAsp-rot-out -121.42, -0.81 -92.81, -3.45 64.76, -20.58 60.99, 19.44 297.14, 26.84 -77.84, 60.22 out-out out 13.201 Saltbr-out 9.588 HRD-out -100.39, 154.9 -77.66, -154.82 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 16.48 APE8-rot-out 62.75 APE67-dihe-in -57.65, -20.32 -54.21, -40.14 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C290A,C393A TPO288 TPO288 XRAY 1.68 0.201 0.231 A 285 253 13 0 0 13 [[133, 383]] 1.0 5l8j Homo sapiens CAMK_AURKA_HUMAN CAMK 9.7e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5L8KA O14965 126 392 403.0 ADP:60501 ATPlike Inactive DFGinter 5.934 8.696 None DFGAsp-rot-out -123.53, 3.87 -94.88, 4.13 68.21, -25.72 51.12, 25.43 307.6, 8.65 -83.23, 69.32 out-out out 12.906 Saltbr-out 9.137 HRD-out -94.24, 154.96 -82.75, -161.39 out-out-out SNCooo out-out ActLoopNT-out 5.262 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -60.54, 152.13 APE9-dihe-na 121.57, -104.82 APE8-dihe-in -138.45, 120.03 APE8-rot-in 300.38 APE67-dihe-in -56.47, -22.96 -75.46, -21.38 APE12-dist-out 14.19 APE11-dist-out 17.885 APE10-dist-out 19.722 APE9-dist-out 13.729 C290A,C393A TPO288 TPO288 XRAY 1.79 0.192 0.235 A 285 267 0 0 0 0 [[133, 383]] 1.0 5l8k Homo sapiens CAMK_AURKA_HUMAN CAMK 9.7e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5L8LA O14965 126 389 403.0 ADP:60501 ATPlike Inactive DFGinter 5.647 8.882 None DFGAsp-rot-out -117.8, 6.57 -92.89, -1.12 55.43, 31.52 53.22, 20.44 289.58, 36.26 -84.0, 68.46 out-out out 12.54 Saltbr-out 9.027 HRD-out -99.09, 148.91 -94.35, -164.8 out-out-out SNCooo out-out ActLoopNT-out 5.393 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -75.26, -165.41 APE9-dihe-na -67.89, -63.26 APE8-dihe-out -124.39, -179.64 APE8-rot-out 64.28 APE67-dihe-in -57.8, -26.84 -83.02, -0.31 APE12-dist-in 11.109 APE11-dist-out 16.52 APE10-dist-out 14.491 APE9-dist-out 14.639 C290A,C393A TPO288 TPO288 XRAY 1.67 0.193 0.223 A 285 264 0 0 0 0 [[133, 383]] 1.0 5l8l Homo sapiens CAMK_AURKA_HUMAN CAMK 9.7e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8PR7A O14965 124 389 403.0 ADP:501 ATPlike Inactive DFGinter 5.07 10.273 None DFGAsp-rot-none -105.95, 148.75 -124.79, 28.7 999.0, 999.0 -129.06, 999.0 303.51, 120.23 999.0, 999.0 out-out out 12.482 Saltbr-out 11.706 HRD-out 52.78, 71.6 -97.43, 142.22 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 47.95, -115.05 APE9-dihe-na -125.01, 9.37 APE8-dihe-out -40.29, -50.01 APE8-rot-out 85.86 APE67-dihe-in -55.11, -34.07 -62.49, -38.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.832 D274N,C290A,N332A,Q335A,T347A,D350A,C393A None None XRAY 2.76 0.205 0.256 A 283 253 13 0 0 13 [[133, 383]] 1.0 8pr7 Homo sapiens CAMK_AURKA_HUMAN CAMK 3.1e-77 265.4 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6XKAA O14965 127 388 403.0 No_ligand No_ligand Inactive DFGinter 8.929 7.51 None DFGAsp-rot-out -127.13, 56.47 -140.31, 176.96 57.25, 0.14 -101.27, 7.78 308.94, 105.52 -69.78, 61.67 out-out out 12.632 Saltbr-out 9.019 HRD-out -107.58, 148.94 -95.64, -139.96 out-out-out SNCooo out-out ActLoopNT-out 5.415 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -48.95 APE8-dihe-out -61.69, -24.7 APE8-rot-in 274.82 APE67-dihe-in -56.0, -24.76 -53.72, -21.76 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 35.053 None None None XRAY 2.65 0.226 0.279 A 292 252 10 0 0 10 [[133, 383]] 1.0 6xka Homo sapiens CAMK_AURKA_HUMAN CAMK 8.6e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2WTVA O14965 125 389 403.0 ZZL:1390 Type1 Inactive DFGinter 5.701 9.454 None DFGAsp-rot-out -75.22, 156.08 -105.21, 156.98 313.97, -45.77 57.55, 45.32 319.02, 110.91 -59.58, -21.68 out-out out 12.224 Saltbr-out 9.738 HRD-out 56.62, 39.51 -65.34, 136.35 out-out-out SNCooo out-out ActLoopNT-out 17.312 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -58.52, -47.8 APE9-dihe-na -54.18, -45.12 APE8-dihe-out -70.51, -43.3 APE8-rot-in 297.14 APE67-dihe-in -48.3, -25.92 -57.93, -45.43 APE12-dist-in 8.287 APE11-dist-in 12.32 APE10-dist-out 15.039 APE9-dist-out 12.589 L215R,T217E,R220K TPO287,TPO288 TPO287,TPO288,CME290 XRAY 2.4 0.167 0.211 A 285 265 0 0 0 0 [[133, 383]] 1.0 2wtv Homo sapiens CAMK_AURKA_HUMAN CAMK 2.8e-81 278.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2WTVB O14965 126 389 403.0 ZZL:1390 Type1 Inactive DFGinter 5.619 9.422 None DFGAsp-rot-out -74.68, 158.58 -101.8, 146.26 307.99, -36.18 63.97, 49.3 317.28, 114.07 -55.55, -26.4 out-out out 12.419 Saltbr-out 10.297 HRD-out -138.44, 123.91 -119.97, 134.75 out-out-out SNCooo out-out ActLoopNT-out 19.511 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na 85.02, 1.5 APE9-dihe-na 116.84, -135.44 APE8-dihe-in -82.25, 112.82 APE8-rot-in 306.92 APE67-dihe-in -64.29, -12.84 -49.83, -55.07 APE12-dist-out 14.754 APE11-dist-out 14.75 APE10-dist-out 12.235 APE9-dist-out 12.287 L215R,T217E,R220K TPO287,TPO288 TPO287,TPO288,CME290 XRAY 2.4 0.167 0.211 B 285 264 0 0 0 0 [[133, 383]] 1.0 2wtv Homo sapiens CAMK_AURKA_HUMAN CAMK 2.8e-81 278.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2WTVC O14965 126 389 403.0 ZZL:1392 Type1 Inactive DFGinter 5.656 9.361 None DFGAsp-rot-out -73.47, 155.34 -96.85, 146.28 309.15, -45.1 67.08, 43.87 316.19, 116.1 -46.77, -31.93 out-out out 12.389 Saltbr-out 10.306 HRD-out -138.88, 125.11 -124.14, 137.81 out-out-out SNCooo out-out ActLoopNT-out 19.519 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na 85.46, 1.21 APE9-dihe-na 119.13, -135.87 APE8-dihe-in -82.97, 108.09 APE8-rot-in 299.33 APE67-dihe-in -62.27, -12.5 -42.96, -58.15 APE12-dist-out 14.766 APE11-dist-out 14.728 APE10-dist-out 12.267 APE9-dist-out 12.403 L215R,T217E,R220K TPO287,TPO288 TPO287,TPO288,CME290 XRAY 2.4 0.167 0.211 C 285 264 0 0 0 0 [[133, 383]] 1.0 2wtv Homo sapiens CAMK_AURKA_HUMAN CAMK 2.8e-81 278.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2WTVD O14965 125 389 403.0 ZZL:1390 Type1 Inactive DFGinter 5.688 9.447 None DFGAsp-rot-out -74.49, 159.41 -108.43, 161.13 315.19, -46.47 55.07, 43.29 317.21, 115.65 -58.54, -27.22 out-out out 12.194 Saltbr-out 9.796 HRD-out 49.31, 42.91 -68.48, 131.43 out-out-out SNCooo out-out ActLoopNT-out 17.059 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iioo APE10-dihe-na -57.61, -41.18 APE9-dihe-na -56.01, -51.32 APE8-dihe-out -76.54, -36.16 APE8-rot-out 70.56 APE67-dihe-in -47.19, -33.07 -56.26, -46.95 APE12-dist-in 8.314 APE11-dist-in 12.48 APE10-dist-out 15.096 APE9-dist-out 12.493 L215R,T217E,R220K TPO287,TPO288 TPO287,TPO288,CME290 XRAY 2.4 0.167 0.211 D 285 265 0 0 0 0 [[133, 383]] 1.0 2wtv Homo sapiens CAMK_AURKA_HUMAN CAMK 2.8e-81 278.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5EW9A O14965 127 390 403.0 5VC:1000 Type1 Inactive DFGinter 7.143 9.146 None DFGAsp-rot-in -125.76, 68.03 -116.07, 111.14 166.84, 28.94 -114.04, 30.21 299.83, 98.64 76.42, 31.17 out-out out 12.208 Saltbr-out 14.928 HRD-out 51.87, 61.64 -81.46, 128.2 out-out-out SNCooo out-out ActLoopNT-out 13.179 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -81.31, 136.15 APE9-dihe-na 106.85, -151.62 APE8-dihe-in -130.38, 126.41 APE8-rot-in 294.67 APE67-dihe-in -61.4, -16.67 -41.18, -56.68 APE12-dist-in 12.108 APE11-dist-in 12.375 APE10-dist-out 8.754 APE9-dist-out 7.261 None TPO287,TPO288 TPO287,TPO288 XRAY 2.181 0.191 0.237 A 271 259 5 0 0 5 [[133, 383]] 1.0 5ew9 Homo sapiens CAMK_AURKA_HUMAN CAMK 6.5e-80 274.1 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6C2RA O14965 128 389 403.0 EG7:404 Type1 Inactive DFGinter 9.162 6.987 None DFGAsp-rot-out -129.68, 71.59 -143.19, 175.42 54.91, 28.28 -111.66, 41.6 306.56, 98.21 -112.1, 49.9 out-none out 12.547 Saltbr-none 999.0 HRD-out -119.24, 148.11 -82.73, -152.25 none-out-out SNCnoo out-out ActLoopNT-out 5.54 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -49.7 APE8-rot-out 174.63 APE67-dihe-in -50.05, -30.9 -49.27, -45.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.96 0.187 0.228 A 272 250 12 0 0 12 [[133, 383]] 1.0 6c2r Homo sapiens CAMK_AURKA_HUMAN CAMK 6.6e-80 274.1 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6C2TA O14965 128 388 403.0 EGJ:401 Type1 Inactive DFGinter 5.758 8.607 None DFGAsp-rot-out -125.5, 12.46 -90.2, -9.56 54.49, 19.72 59.46, 21.11 281.41, 42.78 -76.77, 51.45 out-out out 12.138 Saltbr-out 8.221 HRD-out -119.45, 155.85 -86.58, -149.59 out-out-out SNCooo out-out ActLoopNT-out 5.412 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -68.15, 136.69 APE9-dihe-na 71.69, 6.8 APE8-dihe-out -94.33, -26.09 APE8-rot-out 197.45 APE67-dihe-in -52.44, -25.84 -48.85, -45.94 APE12-dist-out 23.122 APE11-dist-out 26.722 APE10-dist-out 30.388 APE9-dist-out 34.839 None None None XRAY 1.73 0.185 0.22 A 272 253 8 0 0 8 [[133, 383]] 1.0 6c2t Homo sapiens CAMK_AURKA_HUMAN CAMK 6.6e-80 274.1 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3W16A O14965 126 388 403.0 P9J:501 Type1 Inactive DFGinter 8.419 7.071 None DFGAsp-rot-out -121.69, 15.12 -95.95, 166.06 63.56, 6.47 -111.07, 78.29 312.23, 83.01 -146.87, 73.18 out-out out 12.343 Saltbr-out 10.328 HRD-out -113.79, 141.39 -72.7, -138.65 out-out-out SNCooo out-out ActLoopNT-out 5.395 ActLoopCT-out nonTYR APEdihe_aaioo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 65.19 APE8-dihe-in -37.14, 90.48 APE8-rot-out 235.25 APE67-dihe-out -39.45, -35.35 47.17, -54.23 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.494 None None None XRAY 2.8 0.235 0.322 A 278 249 14 0 0 11 [[133, 383]] 1.0 3w16 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.2e-80 274.0 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2J50A O14965 128 389 403.0 627:1390 Type1 Inactive DFGinter 9.246 7.02 None DFGAsp-rot-out -113.57, -10.87 -64.28, 174.0 56.39, 47.45 -114.87, 30.19 305.8, 146.38 -88.31, 66.84 out-out out 12.509 Saltbr-out 9.294 HRD-out -123.95, 152.65 -81.99, -145.81 out-out-out SNCooo out-out ActLoopNT-out 5.444 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -105.31, 129.43 APE9-dihe-na 72.62, 27.27 APE8-dihe-out -102.11, -34.98 APE8-rot-in 309.79 APE67-dihe-in -58.95, -17.94 -50.8, -43.26 APE12-dist-out 19.566 APE11-dist-out 16.656 APE10-dist-out 20.802 APE9-dist-out 14.696 None None None XRAY 3.0 0.221 0.268 A 280 250 12 0 0 8 [[133, 383]] 1.0 2j50 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2J50B O14965 128 389 403.0 627:1390 Type1 Inactive DFGinter 9.246 7.02 None DFGAsp-rot-out -113.53, -10.86 -64.28, 174.02 56.39, 47.48 -114.89, 30.13 305.81, 146.41 -88.25, 66.85 out-out out 12.51 Saltbr-out 9.294 HRD-out -123.96, 152.62 -82.01, -145.78 out-out-out SNCooo out-out ActLoopNT-out 5.445 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -105.31, 129.37 APE9-dihe-na 72.63, 27.29 APE8-dihe-out -102.14, -34.97 APE8-rot-in 309.77 APE67-dihe-in -58.91, -17.97 -50.79, -43.31 APE12-dist-out 19.566 APE11-dist-out 16.656 APE10-dist-out 20.802 APE9-dist-out 14.696 None None None XRAY 3.0 0.221 0.268 B 280 250 12 0 0 8 [[133, 383]] 1.0 2j50 Homo sapiens CAMK_AURKA_HUMAN CAMK 7.4e-80 273.9 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4ZTRA O14965 127 388 403.0 4RJ:501 Type1 Inactive DFGinter 8.997 8.674 None DFGAsp-rot-out -145.71, 65.97 -113.49, 176.73 62.18, -43.27 -135.74, 26.63 211.29, 77.47 -104.42, 142.78 out-out out 13.073 Saltbr-out 9.502 HRD-out 62.28, 87.69 -105.24, 141.97 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -99.17 APE8-dihe-in -82.2, 138.42 APE8-rot-out 194.18 APE67-dihe-in -47.8, -30.35 -87.76, -14.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.49 None None None XRAY 2.85 0.215 0.268 A 285 249 13 0 0 13 [[133, 383]] 1.0 4ztr Homo sapiens CAMK_AURKA_HUMAN CAMK 7.9e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6Z4YA O14965 124 389 403.0 Q7Q:508 Type1 Inactive DFGinter 5.793 8.485 None DFGAsp-rot-in -99.87, -29.52 -56.3, 117.27 187.13, 14.03 -64.91, 155.66 280.74, 8.23 -48.06, 135.67 out-out out 12.261 Saltbr-out 8.724 HRD-out -130.04, 168.56 -116.49, -65.11 out-out-out SNCooo out-out ActLoopNT-out 8.298 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 118.23 APE9-dihe-na -146.9, 152.55 APE8-dihe-in -65.96, 130.4 APE8-rot-in 311.48 APE67-dihe-in -49.06, -39.99 -82.96, -11.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.175 APE9-dist-out 11.101 None None None XRAY 2.25 0.209 0.257 A 285 259 7 0 0 7 [[133, 383]] 1.0 6z4y Homo sapiens CAMK_AURKA_HUMAN CAMK 7.9e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6CPGA O14965 127 387 403.0 35R:501 Type1 Inactive DFGinter 6.711 9.485 None DFGAsp-rot-out -140.02, 96.03 -108.44, 103.16 309.86, -31.7 -141.15, -67.9 302.74, 112.44 175.19, -125.6 out-out out 12.429 Saltbr-out 10.941 HRD-out 55.39, 71.59 -104.21, 123.45 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_nnoo APE10-dihe-na 999.0, -80.02 APE9-dihe-na 97.77, -146.55 APE8-dihe-out -62.97, -12.48 APE8-rot-none 999.0 APE67-dihe-in -58.41, -29.26 -54.85, -41.27 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.041 APE9-dist-out 13.657 None None None XRAY 2.8 0.285 0.335 A 285 249 12 0 0 12 [[133, 383]] 1.0 6cpg Homo sapiens CAMK_AURKA_HUMAN CAMK 7.9e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6CPGD O14965 127 388 403.0 35R:501 Type1 Inactive DFGinter 6.404 9.772 None DFGAsp-rot-in -125.89, 77.36 -98.94, 84.58 188.96, -30.01 -127.68, 52.17 302.92, 103.94 97.64, -149.27 out-out out 11.62 Saltbr-out 12.775 HRD-out 61.84, 98.64 -116.43, 122.15 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nooo APE10-dihe-na -115.97, 178.85 APE9-dihe-na -115.52, -132.49 APE8-dihe-out -76.59, 1.28 APE8-rot-out 68.27 APE67-dihe-in -65.85, -12.72 -75.15, -27.74 APE12-dist-none 999.0 APE11-dist-out 19.388 APE10-dist-out 16.46 APE9-dist-out 14.83 None None None XRAY 2.8 0.285 0.335 D 285 252 10 0 0 10 [[133, 383]] 1.0 6cpg Homo sapiens CAMK_AURKA_HUMAN CAMK 7.9e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8SSOA O14965 127 389 403.0 627:503 Type1 Inactive DFGinter 5.399 10.215 None DFGAsp-rot-out -108.08, -33.36 50.1, -154.98 296.02, -53.91 50.19, 34.56 301.31, 89.86 -57.19, -31.19 out-out out 12.334 Saltbr-out 8.618 HRD-out 58.03, 59.93 -81.1, 151.47 out-out-out SNCooo out-out ActLoopNT-out 16.603 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na -77.17, 142.4 APE9-dihe-na -91.52, -9.13 APE8-dihe-out -58.73, -51.63 APE8-rot-in 325.37 APE67-dihe-in -60.47, -22.49 -51.35, -46.12 APE12-dist-none 999.0 APE11-dist-out 14.244 APE10-dist-out 9.697 APE9-dist-out 11.744 None None None XRAY 1.97 0.194 0.234 A 285 256 7 0 0 7 [[133, 383]] 1.0 8sso Homo sapiens CAMK_AURKA_HUMAN CAMK 7.9e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8SSOD O14965 127 389 403.0 627:501 Type1 Inactive DFGinter 5.281 10.122 None DFGAsp-rot-out -105.7, -31.6 53.01, -156.16 294.94, -80.8 52.08, 37.65 306.05, 89.37 -57.92, -31.1 out-out out 12.291 Saltbr-out 8.476 HRD-out 56.18, 68.26 -87.55, 151.34 out-out-none SNCoon out-none ActLoopNT-out 16.733 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -51.48 APE8-rot-in 286.23 APE67-dihe-in -64.32, -21.7 -60.98, -32.62 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.97 0.194 0.234 D 285 252 11 0 0 11 [[133, 383]] 1.0 8sso Homo sapiens CAMK_AURKA_HUMAN CAMK 7.9e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 1MUOA O14965 128 388 403.0 ADN:1 Type1 Inactive DFGinter 5.924 9.006 None DFGAsp-rot-out -137.2, 91.65 -102.67, 104.14 293.73, -7.27 -141.95, -158.0 317.38, 80.93 -72.97, -80.68 out-out out 11.315 Saltbr-out 7.859 HRD-out -71.01, -147.46 164.07, -11.44 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nooo APE10-dihe-na -39.4, -7.29 APE9-dihe-na -9.41, -37.67 APE8-dihe-out -44.74, -65.33 APE8-rot-in 311.2 APE67-dihe-in -15.91, -41.07 -76.59, -51.98 APE12-dist-none 999.0 APE11-dist-out 18.196 APE10-dist-out 19.849 APE9-dist-out 11.811 None None None XRAY 2.9 0.26 0.29 A 297 251 10 0 0 10 [[133, 383]] 1.0 1muo Homo sapiens CAMK_AURKA_HUMAN CAMK 9.2e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2J4ZA O14965 126 389 403.0 626:1389 Type1 Inactive DFGinter 6.627 9.716 None DFGAsp-rot-out -134.66, 62.98 -108.04, 40.82 76.5, -58.27 -66.1, -23.24 173.81, 60.57 87.3, -158.48 out-out out 12.436 Saltbr-out 8.057 HRD-out 53.27, 78.66 -109.39, 156.45 out-out-out SNCooo out-out ActLoopNT-out 18.635 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oioo APE10-dihe-na -90.61, -7.12 APE9-dihe-na 129.6, -174.7 APE8-dihe-in -67.83, 122.81 APE8-rot-in 307.59 APE67-dihe-in -55.64, -29.26 -49.16, -49.7 APE12-dist-out 15.534 APE11-dist-in 13.84 APE10-dist-out 16.374 APE9-dist-out 7.615 None None None XRAY 2.0 0.214 0.249 A 306 264 0 0 0 0 [[133, 383]] 1.0 2j4z Homo sapiens CAMK_AURKA_HUMAN CAMK 1e-79 273.5 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UNZA O14965 127 389 403.0 0BZ:2 Type1 Inactive DFGinter 5.99 8.922 None DFGAsp-rot-in -84.5, -63.75 54.99, -138.14 236.44, 48.66 56.38, -121.0 215.05, 157.51 -49.6, 129.64 out-out out 11.635 Saltbr-out 8.507 HRD-out 65.37, 47.67 -71.53, 145.54 out-out-out SNCooo out-out ActLoopNT-out 17.162 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 99.65, -2.93 APE9-dihe-na -89.71, 20.26 APE8-dihe-out -80.64, -73.77 APE8-rot-out 51.18 APE67-dihe-in -55.59, -35.44 -82.63, -1.22 APE12-dist-out 14.553 APE11-dist-in 10.839 APE10-dist-out 15.946 APE9-dist-out 14.046 T287D None None XRAY 2.8 0.231 0.278 A 279 263 0 0 0 0 [[133, 383]] 1.0 3unz Homo sapiens CAMK_AURKA_HUMAN CAMK 8.9e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UNZB O14965 127 389 403.0 0BZ:1 Type1 Inactive DFGinter 5.985 8.919 None DFGAsp-rot-in -84.43, -63.71 55.14, -138.06 236.61, 48.53 56.46, -120.92 215.0, 157.19 -49.66, 129.46 out-out out 11.64 Saltbr-out 8.5 HRD-out 65.25, 47.84 -72.14, 146.01 out-out-out SNCooo out-out ActLoopNT-out 17.154 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 99.26, -2.89 APE9-dihe-na -90.04, 20.41 APE8-dihe-out -81.04, -73.69 APE8-rot-out 50.59 APE67-dihe-in -55.45, -35.38 -82.74, -1.38 APE12-dist-out 14.561 APE11-dist-in 10.842 APE10-dist-out 15.95 APE9-dist-out 14.036 T287D None None XRAY 2.8 0.231 0.278 B 279 263 0 0 0 0 [[133, 383]] 1.0 3unz Homo sapiens CAMK_AURKA_HUMAN CAMK 8.9e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UO6A O14965 126 389 403.0 0BY:1 Type1 Inactive DFGinter 6.089 8.947 None DFGAsp-rot-in -92.08, -63.22 55.79, -136.4 223.59, 46.24 58.35, -117.73 204.46, 160.17 -58.84, 166.86 out-out out 11.303 Saltbr-out 11.422 HRD-out 44.35, 72.76 -98.46, 135.56 out-out-out SNCooo out-out ActLoopNT-out 17.227 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 76.96, -17.98 APE9-dihe-na -113.29, 10.31 APE8-dihe-out -74.35, -72.68 APE8-rot-out 36.75 APE67-dihe-in -49.94, -38.95 -75.25, -15.59 APE12-dist-out 14.642 APE11-dist-in 12.205 APE10-dist-out 16.592 APE9-dist-out 14.163 T287D None None XRAY 2.8 0.229 0.276 A 279 264 0 0 0 0 [[133, 383]] 1.0 3uo6 Homo sapiens CAMK_AURKA_HUMAN CAMK 8.9e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UO6B O14965 126 389 403.0 0BY:2 Type1 Inactive DFGinter 6.088 8.935 None DFGAsp-rot-in -92.34, -63.27 55.7, -136.72 223.56, 47.34 58.91, -118.35 204.74, 161.14 -58.96, 166.79 out-out out 11.272 Saltbr-out 11.476 HRD-out 44.24, 73.02 -98.37, 136.49 out-out-out SNCooo out-out ActLoopNT-out 17.232 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 75.5, -18.28 APE9-dihe-na -114.49, 10.92 APE8-dihe-out -74.12, -73.35 APE8-rot-out 38.72 APE67-dihe-in -50.19, -38.98 -73.97, -15.63 APE12-dist-out 14.652 APE11-dist-in 12.209 APE10-dist-out 16.593 APE9-dist-out 14.154 T287D None None XRAY 2.8 0.229 0.276 B 279 264 0 0 0 0 [[133, 383]] 1.0 3uo6 Homo sapiens CAMK_AURKA_HUMAN CAMK 8.9e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UOHA O14965 126 389 403.0 0C4:2 Type1 Inactive DFGinter 6.038 8.914 None DFGAsp-rot-in -93.18, -63.37 54.89, -130.23 203.15, 49.69 58.47, -116.07 202.5, 1.54 -59.86, 169.88 out-out out 12.203 Saltbr-out 10.642 HRD-out 60.57, 51.18 -70.61, 154.26 out-out-out SNCooo out-out ActLoopNT-out 17.297 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 97.37, -1.48 APE9-dihe-na -94.0, 16.64 APE8-dihe-out -73.09, -72.62 APE8-rot-out 34.55 APE67-dihe-in -54.13, -35.68 -91.14, -1.84 APE12-dist-out 14.349 APE11-dist-in 11.496 APE10-dist-out 16.559 APE9-dist-out 14.003 T287D None None XRAY 2.8 0.23 0.288 A 279 264 0 0 0 0 [[133, 383]] 1.0 3uoh Homo sapiens CAMK_AURKA_HUMAN CAMK 8.9e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UOHB O14965 126 389 403.0 0C4:1 Type1 Inactive DFGinter 6.035 8.9 None DFGAsp-rot-in -93.16, -63.34 54.68, -130.86 203.8, 50.91 58.94, -116.29 202.73, 0.89 -60.04, 170.49 out-out out 12.252 Saltbr-out 10.459 HRD-out 56.43, 52.93 -71.71, 154.95 out-out-out SNCooo out-out ActLoopNT-out 17.286 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 97.52, -1.59 APE9-dihe-na -93.94, 16.64 APE8-dihe-out -72.82, -72.33 APE8-rot-out 34.94 APE67-dihe-in -54.2, -36.03 -91.21, -1.67 APE12-dist-out 14.353 APE11-dist-in 11.507 APE10-dist-out 16.576 APE9-dist-out 14.01 T287D None None XRAY 2.8 0.23 0.288 B 279 264 0 0 0 0 [[133, 383]] 1.0 3uoh Homo sapiens CAMK_AURKA_HUMAN CAMK 8.9e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UOJA O14965 127 389 403.0 0C5:1 Type1 Inactive DFGinter 6.25 8.652 None DFGAsp-rot-in -89.03, -64.22 49.6, -140.48 202.36, 83.05 55.65, -113.8 181.43, 6.66 -48.52, 138.84 out-out out 12.901 Saltbr-out 10.167 HRD-out 77.34, -11.89 -40.57, 125.77 out-out-out SNCooo out-out ActLoopNT-out 16.765 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 98.97, 1.26 APE9-dihe-na -102.25, -2.44 APE8-dihe-out -61.85, -58.87 APE8-rot-out 33.31 APE67-dihe-in -56.59, -30.78 -67.25, -33.49 APE12-dist-out 15.388 APE11-dist-in 12.589 APE10-dist-out 17.417 APE9-dist-out 14.292 T287D None None XRAY 2.9 0.227 0.274 A 279 263 0 0 0 0 [[133, 383]] 1.0 3uoj Homo sapiens CAMK_AURKA_HUMAN CAMK 8.9e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UOJB O14965 127 389 403.0 0C5:2 Type1 Inactive DFGinter 6.264 8.645 None DFGAsp-rot-in -88.87, -64.57 49.7, -140.5 202.15, 83.09 55.59, -113.73 181.06, 6.55 -48.5, 138.54 out-out out 12.909 Saltbr-out 10.148 HRD-out 77.24, -11.84 -40.35, 125.95 out-out-out SNCooo out-out ActLoopNT-out 16.76 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 98.86, 1.29 APE9-dihe-na -101.95, -2.75 APE8-dihe-out -62.17, -58.93 APE8-rot-out 33.01 APE67-dihe-in -57.8, -30.14 -66.39, -33.04 APE12-dist-out 15.387 APE11-dist-in 12.586 APE10-dist-out 17.416 APE9-dist-out 14.289 T287D None None XRAY 2.9 0.227 0.274 B 279 263 0 0 0 0 [[133, 383]] 1.0 3uoj Homo sapiens CAMK_AURKA_HUMAN CAMK 8.9e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UOKA O14965 125 389 403.0 0C6:2 Type1 Inactive DFGinter 5.75 9.284 None DFGAsp-rot-in -87.48, -71.36 58.97, -135.37 194.51, 66.3 54.65, -117.02 195.51, 34.07 -55.93, 122.72 out-out out 11.898 Saltbr-out 12.916 HRD-out 40.64, 72.07 -97.16, 132.51 out-out-out SNCooo out-out ActLoopNT-out 17.098 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 75.79, -21.51 APE9-dihe-na -114.86, 8.46 APE8-dihe-out -81.91, -68.59 APE8-rot-out 58.99 APE67-dihe-in -48.81, -38.43 -66.52, -22.51 APE12-dist-out 14.101 APE11-dist-in 12.292 APE10-dist-out 16.966 APE9-dist-out 14.859 T287D None None XRAY 2.951 0.223 0.276 A 279 265 0 0 0 0 [[133, 383]] 1.0 3uok Homo sapiens CAMK_AURKA_HUMAN CAMK 8.9e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UOKB O14965 125 389 403.0 0C6:1 Type1 Inactive DFGinter 5.749 9.277 None DFGAsp-rot-in -88.85, -71.53 59.08, -134.89 194.8, 66.69 54.38, -116.99 195.48, 34.01 -56.06, 122.86 out-out out 11.877 Saltbr-out 12.919 HRD-out 40.28, 71.92 -97.4, 131.84 out-out-out SNCooo out-out ActLoopNT-out 17.078 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 75.7, -21.55 APE9-dihe-na -114.97, 8.84 APE8-dihe-out -82.0, -69.27 APE8-rot-out 58.99 APE67-dihe-in -49.23, -38.63 -66.58, -21.59 APE12-dist-out 14.096 APE11-dist-in 12.283 APE10-dist-out 16.963 APE9-dist-out 14.861 T287D None None XRAY 2.951 0.223 0.276 B 279 265 0 0 0 0 [[133, 383]] 1.0 3uok Homo sapiens CAMK_AURKA_HUMAN CAMK 8.9e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UOLA O14965 127 389 403.0 0C7:2 Type1 Inactive DFGinter 6.069 8.657 None DFGAsp-rot-in -80.65, -49.91 38.66, -132.1 197.67, 72.36 60.59, -110.72 197.86, 22.76 -76.74, 23.35 out-out out 13.78 Saltbr-out 9.949 HRD-out 53.65, 45.58 -63.49, 138.74 out-out-out SNCooo out-out ActLoopNT-out 17.096 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 91.11, -3.8 APE9-dihe-na -96.74, -20.87 APE8-dihe-out -56.71, -68.79 APE8-rot-out 61.79 APE67-dihe-in -54.04, -24.57 -47.13, -38.35 APE12-dist-out 15.112 APE11-dist-in 13.784 APE10-dist-out 17.724 APE9-dist-out 14.403 T287D None None XRAY 2.4 0.237 0.283 A 279 263 0 0 0 0 [[133, 383]] 1.0 3uol Homo sapiens CAMK_AURKA_HUMAN CAMK 8.9e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3UOLB O14965 127 389 403.0 0C7:1 Type1 Inactive DFGinter 5.99 8.66 None DFGAsp-rot-in -80.74, -49.45 38.08, -131.75 197.55, 72.37 60.44, -110.58 198.19, 22.88 -77.08, 23.2 out-out out 13.776 Saltbr-out 9.959 HRD-out 54.22, 44.36 -62.05, 139.57 out-out-out SNCooo out-out ActLoopNT-out 17.093 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oioo APE10-dihe-na 91.25, -3.95 APE9-dihe-na -95.92, -22.22 APE8-dihe-out -56.1, -68.18 APE8-rot-out 62.15 APE67-dihe-in -54.2, -24.78 -47.47, -38.07 APE12-dist-out 15.123 APE11-dist-in 13.791 APE10-dist-out 17.732 APE9-dist-out 14.391 T287D None None XRAY 2.4 0.237 0.283 B 279 263 0 0 0 0 [[133, 383]] 1.0 3uol Homo sapiens CAMK_AURKA_HUMAN CAMK 8.9e-80 273.7 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3FDNA O14965 126 394 403.0 MMH:1 Type1 Inactive DFGinter 5.835 8.7 None DFGAsp-rot-out -113.83, -12.3 -83.93, 150.0 88.19, 12.07 -89.96, 27.39 288.28, 8.62 -77.57, 62.14 out-out out 12.168 Saltbr-out 8.347 HRD-out -96.45, 141.44 -71.53, -154.43 out-out-out SNCooo out-out ActLoopNT-out 5.673 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -102.73 APE9-dihe-na 114.27, 146.94 APE8-dihe-in -67.7, 139.44 APE8-rot-in 273.96 APE67-dihe-in -48.36, -34.0 -88.05, -6.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.575 APE9-dist-out 13.34 T288D None None XRAY 1.9 0.231 0.287 A 279 261 8 0 0 8 [[133, 383]] 1.0 3fdn Homo sapiens CAMK_AURKA_HUMAN CAMK 1.7e-79 272.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3K5UA O14965 126 394 403.0 PFQ:1001 Type1 Inactive DFGinter 5.707 8.825 None DFGAsp-rot-out -107.52, -18.97 -91.45, 151.1 58.95, -11.53 -94.09, 23.54 298.73, 177.78 -72.02, 54.86 out-out out 12.124 Saltbr-out 8.719 HRD-out -88.39, 148.19 -76.48, -155.88 out-out-out SNCooo out-out ActLoopNT-out 5.365 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -121.1 APE9-dihe-na 103.03, 152.44 APE8-dihe-in -66.2, 143.09 APE8-rot-in 275.11 APE67-dihe-in -49.38, -31.53 -92.54, -7.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.461 APE9-dist-out 13.435 T288D None None XRAY 2.35 0.242 0.26 A 279 260 9 0 0 9 [[133, 383]] 1.0 3k5u Homo sapiens CAMK_AURKA_HUMAN CAMK 1.7e-79 272.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4JBQA O14965 126 391 403.0 VX6:501 Type1 Inactive DFGinter 5.863 8.977 None DFGAsp-rot-out -117.17, -3.86 -81.51, -172.59 53.23, 32.28 -125.34, 20.35 277.47, 29.16 -74.78, 56.29 out-out out 12.325 Saltbr-out 9.46 HRD-out -106.24, 150.32 -82.52, -162.88 out-out-out SNCooo out-out ActLoopNT-out 5.42 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 124.19 APE9-dihe-na 110.15, 136.99 APE8-dihe-in -65.42, 141.32 APE8-rot-out 182.94 APE67-dihe-in -48.15, -34.26 -90.56, -13.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 16.718 APE9-dist-out 13.313 T288D None None XRAY 2.3 0.227 0.282 A 279 257 9 0 0 9 [[133, 383]] 1.0 4jbq Homo sapiens CAMK_AURKA_HUMAN CAMK 1.7e-79 272.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3LAUA O14965 125 391 403.0 OFI:60001 Type1 Inactive DFGinter 4.874 9.47 None DFGAsp-rot-out -122.68, 72.55 -135.5, 105.71 75.7, -65.12 -124.13, 999.0 233.96, 104.58 999.0, 999.0 out-out out 11.612 Saltbr-out 10.851 HRD-out 60.88, 64.76 -92.19, 140.49 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.81, -17.37 999.0, -42.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 T288D None None XRAY 2.1 0.203 0.248 A 287 250 17 0 0 17 [[133, 383]] 1.0 3lau Homo sapiens CAMK_AURKA_HUMAN CAMK 1.9e-79 272.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4UZHA O14965 125 392 403.0 JVE:61392 Type1 Inactive DFGinter 6.165 8.847 None DFGAsp-rot-out -134.4, 63.5 -102.61, 61.53 61.13, -47.74 -163.5, 999.0 153.81, 66.79 999.0, 999.0 out-out out 11.616 Saltbr-out 7.197 HRD-out 56.64, 70.94 -95.92, 131.49 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -61.98, -11.66 999.0, -76.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.205 0.235 A 287 251 17 0 0 17 [[133, 383]] 1.0 4uzh Homo sapiens CAMK_AURKA_HUMAN CAMK 1.9e-79 272.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3H0YA O14965 126 388 403.0 48B:1 Type1 Inactive DFGinter 6.252 8.418 None DFGAsp-rot-out -109.47, -26.38 -75.33, 137.27 57.05, 77.95 -77.12, 162.45 293.82, 171.84 -85.27, 155.38 out-out out 11.756 Saltbr-out 8.407 HRD-out -128.83, 133.48 -56.66, -46.86 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 129.6 APE8-rot-out 181.19 APE67-dihe-in -47.87, -33.3 -84.26, -9.95 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K124A,T287A,T288A None None XRAY 2.5 0.216 0.285 A 268 250 13 0 0 13 [[133, 383]] 1.0 3h0y Homo sapiens CAMK_AURKA_HUMAN CAMK 4e-79 271.5 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3H10A O14965 124 391 403.0 97B:1 Type1 Inactive DFGinter 5.949 9.292 None DFGAsp-rot-out -85.74, 156.36 -96.9, 153.5 319.92, -30.19 66.79, 45.29 317.78, 104.47 -57.91, -32.92 out-out out 11.685 Saltbr-out 10.318 HRD-out 59.2, 41.52 -65.77, 140.34 out-out-out SNCooo out-out ActLoopNT-out 17.434 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -128.56, 51.89 APE9-dihe-na 117.04, -170.29 APE8-dihe-in -90.19, 120.52 APE8-rot-in 294.83 APE67-dihe-in -57.04, -32.9 -46.43, -51.7 APE12-dist-in 10.276 APE11-dist-out 14.601 APE10-dist-out 13.537 APE9-dist-out 10.476 K124A,T287A,T288A None None XRAY 2.2 0.197 0.24 A 268 268 0 0 0 0 [[133, 383]] 1.0 3h10 Homo sapiens CAMK_AURKA_HUMAN CAMK 4e-79 271.5 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3H10B O14965 125 391 403.0 97B:2 Type1 Inactive DFGinter 6.086 9.1 None DFGAsp-rot-out -84.1, 155.64 -96.32, 147.85 310.3, -36.72 67.68, 47.0 313.1, 101.31 -64.96, -29.8 out-out out 11.348 Saltbr-out 9.737 HRD-out 52.62, 55.73 -75.29, 145.84 out-out-out SNCooo out-out ActLoopNT-out 17.595 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -164.73, 70.51 APE9-dihe-na 110.59, 173.85 APE8-dihe-in -85.08, 117.86 APE8-rot-in 292.57 APE67-dihe-in -65.77, -24.94 -40.25, -55.5 APE12-dist-in 10.377 APE11-dist-out 14.491 APE10-dist-out 13.091 APE9-dist-out 10.674 K124A,T287A,T288A None None XRAY 2.2 0.197 0.24 B 268 267 0 0 0 0 [[133, 383]] 1.0 3h10 Homo sapiens CAMK_AURKA_HUMAN CAMK 4e-79 271.5 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3H10D O14965 126 388 403.0 97B:3 Type1 Inactive DFGinter 5.652 9.351 None DFGAsp-rot-out -78.35, 156.2 -102.03, 146.36 308.32, -33.16 61.53, 46.31 320.5, 110.27 -53.35, -35.87 out-out out 12.271 Saltbr-out 10.405 HRD-out 47.1, 36.06 -65.28, 120.88 out-out-none SNCoon out-none ActLoopNT-out 16.933 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 130.75 APE8-rot-in 285.65 APE67-dihe-in -49.42, -30.99 -50.38, -44.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K124A,T287A,T288A None None XRAY 2.2 0.197 0.24 D 268 255 8 0 0 8 [[133, 383]] 1.0 3h10 Homo sapiens CAMK_AURKA_HUMAN CAMK 4e-79 271.5 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3P9JA O14965 126 388 403.0 P9J:1 Type1 Inactive DFGinter 6.884 7.941 None DFGAsp-rot-out -102.4, -6.03 -81.85, 156.26 82.32, -23.03 -90.38, 17.14 289.53, 9.94 -77.54, 34.79 out-out out 12.372 Saltbr-out 9.879 HRD-out -106.04, 150.63 -81.01, -161.23 out-out-out SNCooo out-out ActLoopNT-out 5.35 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 98.73 APE8-dihe-in -129.65, 90.21 APE8-rot-out 170.24 APE67-dihe-in -44.1, -38.87 -140.2, 19.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.103 T287A,T288A None None XRAY 2.8 0.204 0.271 A 268 249 14 0 0 11 [[133, 383]] 1.0 3p9j Homo sapiens CAMK_AURKA_HUMAN CAMK 4e-79 271.5 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3W10A O14965 126 388 403.0 RO9:501 Type1 Inactive DFGinter 6.373 9.695 None DFGAsp-rot-out -119.04, 54.38 -98.61, 30.05 66.47, -31.36 -138.73, 164.74 58.12, 85.11 47.87, 16.56 out-out out 11.801 Saltbr-out 10.333 HRD-out 62.97, 65.74 -95.42, 130.99 out-out-out SNCooo out-out ActLoopNT-out 17.48 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iooo APE10-dihe-na -81.52, 14.87 APE9-dihe-na -42.97, -40.22 APE8-dihe-out -121.83, 17.25 APE8-rot-out 76.19 APE67-dihe-in -68.64, -18.29 -61.37, -40.89 APE12-dist-in 9.752 APE11-dist-out 14.714 APE10-dist-out 16.055 APE9-dist-out 11.775 T287A,T288A None None XRAY 2.7 0.249 0.309 A 278 263 0 0 0 0 [[133, 383]] 1.0 3w10 Homo sapiens CAMK_AURKA_HUMAN CAMK 4.6e-79 271.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3R22A O14965 126 389 403.0 D37:1 Type1 Inactive DFGinter 6.472 8.557 None DFGAsp-rot-in -142.77, -34.51 -91.78, -141.21 229.55, 36.12 -154.74, 60.2 276.78, 88.9 -152.2, 21.14 out-out out 11.924 Saltbr-out 7.894 HRD-out -77.07, 147.44 -101.45, -61.81 out-out-out SNCooo out-out ActLoopNT-out 4.786 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 163.54 APE8-dihe-in -57.16, 146.3 APE8-rot-out 184.12 APE67-dihe-in -47.8, -31.62 -95.89, 1.66 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.996 T287D,T288D None None XRAY 2.9 0.271 0.313 A 271 255 9 0 0 9 [[133, 383]] 1.0 3r22 Homo sapiens CAMK_AURKA_HUMAN CAMK 1.8e-79 272.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 9KDSA O14965 126 391 403.0 A1EFT:220 Type1 Inactive DFGinter 5.841 9.061 None DFGAsp-rot-out -115.36, -22.96 -73.25, 150.65 63.32, 66.51 -96.11, 14.3 285.47, 2.42 -64.22, 74.88 out-out out 12.262 Saltbr-out 9.104 HRD-out -98.78, 149.89 -79.07, -155.21 out-out-out SNCooo out-out ActLoopNT-out 5.2 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -139.65 APE8-dihe-in -67.03, 136.06 APE8-rot-in 265.66 APE67-dihe-in -47.15, -28.7 -90.01, -5.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.643 C290A None A1EFT220 XRAY 2.5 0.217 0.253 A 266 257 9 0 0 9 [[133, 383]] 1.0 9kds Homo sapiens CAMK_AURKA_HUMAN CAMK 1e-78 270.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2BMCA O14965 127 394 403.0 MPY:1395 Type1 Inactive DFGinter 6.581 8.649 None DFGAsp-rot-out -120.22, 2.69 -79.74, 177.87 50.0, 44.14 -120.44, 28.65 279.36, 74.44 -63.39, 54.99 out-out out 12.712 Saltbr-out 9.648 HRD-out -124.67, 146.35 -86.18, -146.55 out-out-out SNCooo out-out ActLoopNT-out 5.399 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -132.56 APE8-rot-out 47.16 APE67-dihe-in -49.36, -30.39 -47.35, -35.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.228 0.252 A 306 256 12 0 0 12 [[133, 383]] 1.0 2bmc Homo sapiens CAMK_AURKA_HUMAN CAMK 2.9e-79 272.0 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2BMCB O14965 125 394 403.0 MPY:1395 Type1 Inactive DFGinter 6.807 8.53 None DFGAsp-rot-out -121.32, 0.27 -78.21, 179.92 51.44, 40.1 -122.08, 26.9 281.74, 72.08 -64.82, 57.86 out-out out 12.742 Saltbr-out 9.349 HRD-out -129.07, 147.12 -89.63, -143.13 out-out-out SNCooo out-out ActLoopNT-out 5.335 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -148.66 APE8-rot-out 47.86 APE67-dihe-in -45.98, -40.8 -48.24, -32.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.228 0.252 B 306 258 12 0 0 12 [[133, 383]] 1.0 2bmc Homo sapiens CAMK_AURKA_HUMAN CAMK 2.9e-79 272.0 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2BMCC O14965 125 393 403.0 MPY:1394 Type1 Inactive DFGinter 6.84 8.563 None DFGAsp-rot-out -111.71, -8.17 -78.0, 176.81 56.83, 39.87 -119.82, 27.04 283.62, 65.51 -62.65, 57.16 out-out out 12.759 Saltbr-out 9.29 HRD-out -129.54, 151.84 -86.76, -144.72 out-out-out SNCooo out-out ActLoopNT-out 5.453 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -175.11 APE8-rot-out 45.5 APE67-dihe-in -27.05, -38.79 -54.18, -36.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.228 0.252 C 306 257 12 0 0 12 [[133, 383]] 1.0 2bmc Homo sapiens CAMK_AURKA_HUMAN CAMK 2.9e-79 272.0 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2BMCD O14965 127 394 403.0 MPY:1395 Type1 Inactive DFGinter 6.797 8.666 None DFGAsp-rot-out -115.73, -0.95 -79.88, 179.36 59.43, 51.25 -120.07, 22.55 284.5, 74.5 -63.99, 59.56 out-out out 12.681 Saltbr-out 9.214 HRD-out -128.93, 150.36 -86.55, -146.18 out-out-out SNCooo out-out ActLoopNT-out 5.448 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -170.43 APE8-rot-out 54.46 APE67-dihe-in -29.4, -31.11 -37.9, -57.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.228 0.252 D 306 256 12 0 0 12 [[133, 383]] 1.0 2bmc Homo sapiens CAMK_AURKA_HUMAN CAMK 2.9e-79 272.0 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2BMCE O14965 127 394 403.0 MPY:1395 Type1 Inactive DFGinter 6.826 8.489 None DFGAsp-rot-out -115.38, -3.61 -77.32, 179.54 58.35, 54.94 -120.22, 21.67 284.65, 76.22 -63.51, 61.05 out-out out 12.642 Saltbr-out 9.434 HRD-out -126.37, 151.8 -84.41, -148.69 out-out-out SNCooo out-out ActLoopNT-out 5.452 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -151.66 APE8-rot-out 63.51 APE67-dihe-in -26.62, -34.28 -40.09, -60.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.228 0.252 E 306 256 12 0 0 12 [[133, 383]] 1.0 2bmc Homo sapiens CAMK_AURKA_HUMAN CAMK 2.9e-79 272.0 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 2BMCF O14965 126 394 403.0 MPY:1395 Type1 Inactive DFGinter 6.508 8.822 None DFGAsp-rot-out -115.69, -5.93 -78.56, 177.32 60.24, 37.71 -122.14, 28.38 282.23, 67.06 -65.82, 60.75 out-out out 12.753 Saltbr-out 9.271 HRD-out -127.86, 148.46 -84.63, -148.84 out-out-out SNCooo out-out ActLoopNT-out 5.413 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -159.21 APE8-rot-out 48.76 APE67-dihe-in -12.19, -42.56 -50.87, -58.05 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.6 0.228 0.252 F 306 257 12 0 0 12 [[133, 383]] 1.0 2bmc Homo sapiens CAMK_AURKA_HUMAN CAMK 2.9e-79 272.0 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 7FICA O14965 127 391 403.0 5YZ:401 Type1 Inactive DFGinter 6.656 8.698 None DFGAsp-rot-in -127.87, 74.52 -84.56, 58.76 202.82, 3.75 -143.59, 98.4 223.5, 108.01 121.48, 144.52 out-none out 11.431 Saltbr-none 999.0 HRD-out -142.2, 146.4 -144.31, 136.82 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 142.56 APE9-dihe-na -122.69, 31.13 APE8-dihe-out -54.83, -47.63 APE8-rot-out 52.3 APE67-dihe-in -64.7, -30.85 -67.62, -21.57 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.168 APE9-dist-out 15.104 C290A None None XRAY 2.32 0.237 0.274 A 265 254 11 0 0 11 [[133, 383]] 1.0 7fic Homo sapiens CAMK_AURKA_HUMAN CAMK 7.4e-79 270.6 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 9BZGA O14965 127 388 403.0 OG0:501 Type1 Inactive DFGinter 5.574 8.954 None DFGAsp-rot-out -138.21, 40.41 -80.38, -6.22 66.52, -44.17 -58.44, 128.99 169.82, 66.7 87.71, 11.81 out-out out 12.011 Saltbr-out 11.35 HRD-out 57.43, 61.28 -82.68, 137.68 out-out-out SNCooo out-out ActLoopNT-out 16.905 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -68.5, -47.56 APE9-dihe-na -63.47, -40.24 APE8-dihe-out -67.43, -41.81 APE8-rot-in 291.8 APE67-dihe-in -55.03, -25.33 -61.13, -40.77 APE12-dist-in 8.031 APE11-dist-in 12.176 APE10-dist-out 14.813 APE9-dist-out 11.654 C290A,C393S TPO288 TPO288 XRAY 1.8 0.188 0.22 A 285 262 0 0 0 0 [[133, 383]] 1.0 9bzg Homo sapiens CAMK_AURKA_HUMAN CAMK 9.7e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 9BZLB O14965 127 388 403.0 OGR:501 Type1 Inactive DFGinter 5.652 8.924 None DFGAsp-rot-out -136.55, 35.09 -77.99, -4.99 60.43, -38.27 -64.56, 136.29 165.56, 68.13 84.66, 11.21 out-out out 12.145 Saltbr-out 11.508 HRD-out 58.91, 63.34 -81.19, 137.19 out-out-out SNCooo out-out ActLoopNT-out 16.842 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na -64.8, -45.23 APE9-dihe-na -65.62, -37.14 APE8-dihe-out -65.61, -42.19 APE8-rot-in 287.26 APE67-dihe-in -56.13, -23.23 -60.59, -40.07 APE12-dist-in 8.118 APE11-dist-in 11.676 APE10-dist-out 14.621 APE9-dist-out 11.701 C290A,C393S TPO288 TPO288 XRAY 1.81 0.192 0.214 B 285 262 0 0 0 0 [[133, 383]] 1.0 9bzl Homo sapiens CAMK_AURKA_HUMAN CAMK 9.7e-79 270.3 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 9KS6A O14965 127 391 403.0 A1EG1:162 Type1 Inactive DFGinter 5.888 9.106 None DFGAsp-rot-out -147.81, 30.43 -100.08, -15.16 50.94, -31.77 61.73, 18.3 290.83, 10.75 -77.9, 72.48 out-na out 12.472 Saltbr-na 9.13 HRD-out -111.85, 134.04 -63.11, -66.03 na-none-none SNCann none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 127.23 APE8-rot-in 299.78 APE67-dihe-in -48.85, -29.53 -94.69, -1.61 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None A1EG1162 XRAY 2.75 0.232 0.267 A 265 251 14 0 0 14 [[133, 383]] 1.0 9ks6 Homo sapiens CAMK_AURKA_HUMAN CAMK 2.6e-78 268.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4ZTQA O14965 127 388 403.0 4RM:501 Type1.5_Back Inactive DFGinter 9.794 7.55 None DFGAsp-rot-out -128.95, 86.44 -158.65, -177.96 61.36, 22.43 -107.17, 35.48 297.86, 94.26 -105.4, 22.98 out-out out 11.777 Saltbr-out 13.148 HRD-out -111.76, 156.87 -90.96, -144.93 out-out-out SNCooo out-out ActLoopNT-out 5.266 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -178.64 APE8-dihe-in -81.15, 143.47 APE8-rot-out 185.07 APE67-dihe-in -33.25, -44.07 -77.96, -26.17 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.941 None None None XRAY 2.8 0.203 0.246 A 285 247 15 0 0 11 [[133, 383]] 1.0 4ztq Homo sapiens CAMK_AURKA_HUMAN CAMK 7.9e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 4ZTSA O14965 127 388 403.0 4RK:501 Type1.5_Back Inactive DFGinter 9.857 7.612 None DFGAsp-rot-out -142.98, 93.02 -162.47, -179.72 59.4, 21.49 -105.27, 64.86 290.53, 116.01 159.83, 107.65 out-out out 12.238 Saltbr-out 12.539 HRD-out -124.72, 145.07 -84.3, -151.71 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 133.6 APE8-rot-out 180.3 APE67-dihe-in -43.16, -25.38 -86.65, -10.5 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.9 0.213 0.249 A 285 249 13 0 0 13 [[133, 383]] 1.0 4zts Homo sapiens CAMK_AURKA_HUMAN CAMK 7.9e-80 273.8 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3EFWA O14965 126 388 403.0 AK8:404 Type1.5_Front Inactive DFGinter 6.166 9.192 None DFGAsp-rot-in -114.69, 29.1 -93.31, 98.64 213.81, -64.46 -72.68, 999.0 277.06, 45.29 999.0, 999.0 out-none out 12.504 Saltbr-none 999.0 HRD-out -100.96, 129.93 -74.44, -133.77 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -49.97, -16.9 999.0, -48.34 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.29 0.26 0.295 A 267 240 23 0 0 17 [[133, 383]] 1.0 3efw Homo sapiens CAMK_AURKA_HUMAN CAMK 6.2e-80 274.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3EFWB O14965 126 389 403.0 AK8:404 Type1.5_Front Inactive DFGinter 6.843 8.718 None DFGAsp-rot-out -97.71, -18.22 -58.8, 127.67 296.84, -65.8 -71.64, 999.0 297.41, 150.5 999.0, 999.0 out-out out 12.831 Saltbr-out 9.752 HRD-out -122.37, 142.08 -72.73, -61.12 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -56.59, -24.0 999.0, -41.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.29 0.26 0.295 B 267 242 22 0 0 17 [[133, 383]] 1.0 3efw Homo sapiens CAMK_AURKA_HUMAN CAMK 6.2e-80 274.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3O50A O14965 126 388 403.0 LJE:1 Type1.5_Front Inactive DFGinter 6.926 8.59 None DFGAsp-rot-in -120.45, 57.47 -126.6, 83.94 204.27, -76.74 -51.28, 45.89 305.79, 65.53 -47.9, 167.61 out-out out 12.771 Saltbr-out 9.688 HRD-out -105.95, -54.24 71.67, 50.89 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 121.18 APE8-rot-out 177.59 APE67-dihe-in -53.46, -33.48 -54.98, -22.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.285 0.351 A 267 246 17 0 0 14 [[133, 383]] 1.0 3o50 Homo sapiens CAMK_AURKA_HUMAN CAMK 6.2e-80 274.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 3O50B O14965 126 389 403.0 LJE:1 Type1.5_Front Inactive DFGinter 7.129 8.801 None DFGAsp-rot-in -108.79, 36.5 -105.08, 99.13 215.11, 89.31 -72.4, 999.0 308.79, 175.58 999.0, 999.0 out-out out 12.868 Saltbr-out 9.636 HRD-out -123.96, 166.98 -117.96, 27.18 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na -123.8, 136.42 APE9-dihe-na -70.48, -112.85 APE8-dihe-in -82.24, 115.2 APE8-rot-out 163.63 APE67-dihe-in -35.05, -31.99 -65.91, -24.75 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 9.327 None None None XRAY 2.0 0.285 0.351 B 267 249 15 0 0 11 [[133, 383]] 1.0 3o50 Homo sapiens CAMK_AURKA_HUMAN CAMK 6.2e-80 274.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 6HJJA O14965 127 393 403.0 G7T:501 Type1.5_Front Inactive DFGinter 6.251 8.493 None DFGAsp-rot-out -112.85, -19.21 -86.09, 145.25 84.13, -52.92 -81.54, -160.25 301.92, 166.71 41.76, 103.89 out-out out 12.308 Saltbr-out 9.311 HRD-out -108.67, 152.78 -84.21, -142.85 out-out-out SNCooo out-out ActLoopNT-out 5.702 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 176.9 APE8-dihe-in -60.46, 140.32 APE8-rot-out 182.81 APE67-dihe-in -42.69, -33.03 -85.17, -13.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.22 L210C,C290A,C393A None None XRAY 2.13 0.212 0.269 A 285 256 11 0 0 11 [[133, 383]] 1.0 6hjj Homo sapiens CAMK_AURKA_HUMAN CAMK 4.3e-78 268.2 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKB AURKB_HUMAN 4AF3A Q96GD4 70 338 344.0 VX6:500 Type1 Inactive DFGinter 6.226 9.08 None DFGAsp-rot-none -112.4, 112.13 -127.45, 99.79 999.0, 999.0 -141.88, 168.72 285.68, 83.55 155.44, 999.0 out-out out 12.18 Saltbr-out 9.93 HRD-out -154.61, 151.72 -150.08, 147.62 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -62.83, -29.23 999.0, -55.56 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.75 0.208 0.264 A 292 253 16 0 0 16 [[77, 327]] 1.0 4af3 Homo sapiens CAMK_AURKB_HUMAN CAMK 3.7e-80 274.9 1 256 256 217 218 219 221 223 106 125 129 197 199 198 200 255 243 238 237 236 235 234 233 232 155 Aurora kinase B
CAMK CAMK1 KCC1A_HUMAN 4FG9A Q14012 10 314 370.0 ATP:401 ATPlike Inactive DFGinter 6.372 9.923 None DFGAsp-rot-in -94.72, -48.11 -72.17, 151.42 230.85, -70.62 -111.14, 999.0 291.22, 108.3 999.0, 999.0 out-out out 13.251 Saltbr-out 11.213 HRD-in -52.69, -68.08 75.14, -19.91 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 133.2, -24.01 999.0, 22.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.211 0.249 A 320 278 27 0 0 18 [[20, 276]] 1.0 4fg9 Homo sapiens CAMK_CAMK1_HUMAN CAMK 9.5e-97 329.5 1 256 256 161 162 163 165 167 49 66 70 138 140 139 141 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1 KCC1A_HUMAN 4FG9B Q14012 14 314 370.0 ATP:401 ATPlike Inactive DFGinter 6.287 9.324 None DFGAsp-rot-in -97.62, -42.8 -76.25, 145.4 212.44, -67.78 -105.57, 999.0 303.86, 102.8 999.0, 999.0 out-none out 16.899 Saltbr-none 999.0 HRD-in -42.26, -58.83 67.77, -17.08 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na -80.77, -34.84 APE9-dihe-na -79.39, -52.09 APE8-dihe-in -108.11, 99.06 APE8-rot-none 999.0 APE67-dihe-inflip 97.92, -38.15 -85.42, 136.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.53 None None None XRAY 2.4 0.211 0.249 B 320 279 22 0 0 10 [[20, 276]] 1.0 4fg9 Homo sapiens CAMK_CAMK1_HUMAN CAMK 9.5e-97 329.5 1 256 256 161 162 163 165 167 49 66 70 138 140 139 141 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1 KCC1A_HUMAN 4FGBA Q14012 10 299 370.0 No_ligand No_ligand Inactive DFGinter 5.739 10.203 None DFGAsp-rot-in -104.6, -8.49 -140.3, 178.11 193.46, 14.24 -139.41, 147.23 303.38, 89.89 -87.78, 114.08 out-out out 11.588 Saltbr-out 11.141 HRD-in -53.9, -58.19 79.4, -20.41 out-out-out SNCooo out-out ActLoopNT-out 8.528 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooo APE10-dihe-na -82.45, -17.55 APE9-dihe-na -76.06, -99.18 APE8-dihe-in -116.77, 89.48 APE8-rot-in 320.21 APE67-dihe-in -68.84, -25.9 -53.31, -20.17 APE12-dist-in 11.625 APE11-dist-out 16.719 APE10-dist-out 18.072 APE9-dist-out 11.41 None None None XRAY 2.6 0.251 0.299 A 320 282 8 0 0 0 [[20, 276]] 1.0 4fgb Homo sapiens CAMK_CAMK1_HUMAN CAMK 9.5e-97 329.5 1 256 256 161 162 163 165 167 49 66 70 138 140 139 141 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1D KCC1D_HUMAN 6T6FA Q8IU85 12 329 385.0 MMW:60401 Type1 Inactive DFGinter 6.182 10.448 None DFGAsp-rot-in -113.61, 0.12 -149.43, 165.51 199.63, 5.92 -125.03, 154.94 303.02, 100.18 -111.73, 79.48 out-out out 12.704 Saltbr-out 10.425 HRD-in -70.96, -50.52 78.73, -1.15 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -64.19, -30.52 999.0, -10.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.97 0.211 0.238 A 322 289 15 0 0 15 [[23, 279]] 1.0 6t6f Homo sapiens CAMK_CAMK1D_HUMAN CAMK 1.9e-99 338.2 1 256 256 164 165 166 168 170 52 69 73 141 143 142 144 203 191 186 185 184 183 182 181 180 99 Calcium/calmodulin-dependent protein kinase type 1D
CAMK CAMK1D KCC1D_HUMAN 6T6FB Q8IU85 12 329 385.0 MMW:60401 Type1 Inactive DFGinter 6.352 10.343 None DFGAsp-rot-in -113.49, -0.83 -150.4, 164.72 196.4, 2.02 -127.1, 154.02 307.16, 95.57 -112.6, 999.0 out-out out 12.519 Saltbr-out 10.223 HRD-in -67.18, -47.77 75.41, 3.11 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none -62.9, -29.75 999.0, -9.36 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.97 0.211 0.238 B 322 286 17 0 0 17 [[23, 279]] 1.0 6t6f Homo sapiens CAMK_CAMK1D_HUMAN CAMK 1.9e-99 338.2 1 256 256 164 165 166 168 170 52 69 73 141 143 142 144 203 191 186 185 184 183 182 181 180 99 Calcium/calmodulin-dependent protein kinase type 1D
CAMK CAMK1D KCC1D_HUMAN 6T29AAA Q8IU85 12 302 385.0 M8Z:410 Type1 Inactive DFGinter 6.687 10.95 None DFGAsp-rot-in -86.27, -17.21 -161.15, 144.55 188.84, 22.89 -156.05, 155.34 64.59, 91.39 -93.17, 151.07 out-out out 13.659 Saltbr-out 10.396 HRD-in -62.46, -51.48 74.27, -6.64 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, -37.69 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.484 0.137 0.175 AAA 385 274 17 0 0 17 [[23, 279]] 1.0 6t29 Homo sapiens CAMK_CAMK1D_HUMAN CAMK 3.4e-99 337.4 1 256 256 164 165 166 168 170 52 69 73 141 143 142 144 203 191 186 185 184 183 182 181 180 99 Calcium/calmodulin-dependent protein kinase type 1D
CAMK CAMK2A KCC2A_HUMAN 6W4OO Q9UQM7 7 301 478.0 No_ligand No_ligand Inactive DFGinter 10.806 10.238 None DFGAsp-rot-in -98.81, 109.81 -79.77, 114.68 178.7, 0.63 -136.99, 147.47 315.53, 123.33 104.37, -23.29 in-na in 8.798 Saltbr-na 999.0 HRD-in -73.78, -41.7 68.26, -19.24 na-in-in SNCaii in-in ActLoopNT-in 3.181 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.12, 161.52 APE9-dihe-na 103.65, -177.0 APE8-dihe-in -98.82, 133.37 APE8-rot-in 301.51 APE67-dihe-in -73.83, -31.08 -42.99, -42.18 APE12-dist-in 9.829 APE11-dist-in 10.848 APE10-dist-in 5.275 APE9-dist-in 3.989 K42M None None EM 4.8 999.0 999.0 O 473 293 2 0 0 0 [[13, 271]] 1.0 6w4o Homo sapiens CAMK_CAMK2A_HUMAN CAMK 3.4e-93 318.2 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 6W4PH Q9UQM7 7 301 478.0 No_ligand No_ligand Inactive DFGinter 10.806 10.237 None DFGAsp-rot-in -98.91, 109.73 -79.66, 114.62 178.76, 0.59 -137.0, 147.49 315.5, 123.34 104.35, -23.19 in-na in 8.799 Saltbr-na 999.0 HRD-in -73.79, -41.59 68.22, -19.25 na-in-in SNCaii in-in ActLoopNT-in 3.181 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.15, 161.56 APE9-dihe-na 103.69, -177.07 APE8-dihe-in -98.77, 133.22 APE8-rot-in 301.62 APE67-dihe-in -73.83, -31.05 -42.85, -42.28 APE12-dist-in 9.829 APE11-dist-in 10.849 APE10-dist-in 5.276 APE9-dist-in 3.988 K42M None None EM 6.6 999.0 999.0 H 473 293 2 0 0 0 [[13, 271]] 1.0 6w4p Homo sapiens CAMK_CAMK2A_HUMAN CAMK 3.4e-93 318.2 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 3SOAA Q9UQM7 7 474 478.0 DB8:60445 Type1 Inactive DFGinter 10.807 10.237 None DFGAsp-rot-in -98.86, 109.77 -79.7, 114.69 178.76, 0.53 -137.02, 147.48 315.53, 123.27 104.35, -23.23 in-na in 8.799 Saltbr-na 999.0 HRD-in -73.81, -41.57 68.14, -19.19 na-in-in SNCaii in-in ActLoopNT-in 3.181 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -150.13, 161.55 APE9-dihe-na 103.67, -177.05 APE8-dihe-in -98.78, 133.3 APE8-rot-in 301.55 APE67-dihe-in -73.82, -31.03 -42.95, -42.2 APE12-dist-in 9.829 APE11-dist-in 10.848 APE10-dist-in 5.275 APE9-dist-in 3.989 K42M,D135N,T306V None None XRAY 3.55 0.279 0.327 A 444 436 2 0 0 0 [[13, 271]] 1.0 3soa Homo sapiens CAMK_CAMK2A_HUMAN CAMK 2.8e-93 318.5 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK MARK3 MARK3_HUMAN 9YR9B P27448 49 366 753.0 A1CZY:401 Type1 Inactive DFGinter 5.066 10.889 None DFGAsp-rot-in -108.7303, 7.4554 -91.0978, 121.7543 188.5188, 0.6861 -123.6064, 13.5626 296.6271, 91.5036 -86.8982, 110.869 out-out out 10.044 Saltbr-out 5.354 HRD-out -61.1308, 133.7274 -64.2942, -49.7121 out-out-none SNCoon out-none ActLoopNT-out 5.991 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.402 0.209 0.253 B 325 291 27 0 0 13 [[56, 307]] 1.0 9yr9 Homo sapiens CAMK_MARK3_HUMAN CAMK 4.6e-96 327.1 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
CAMK MARK3 MARK3_HUMAN 9ZZWB P27448 49 366 753.0 A1C86:401 Type1 Inactive DFGinter 5.343 10.891 None DFGAsp-rot-in -102.9518, 5.0161 -90.5833, 103.1997 175.2656, 56.9936 -103.5954, 16.8437 297.9676, 93.0842 -88.9928, 104.8868 in-none in 9.777 Saltbr-none 999.0 HRD-out -65.103, 137.748 -63.4929, -42.9642 none-out-none SNCnon out-none ActLoopNT-out 5.904 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.76 0.259 0.286 B 325 270 48 0 0 19 [[56, 307]] 1.0 9zzw Homo sapiens CAMK_MARK3_HUMAN CAMK 4.6e-96 327.1 1 256 256 195 196 197 199 201 85 103 107 175 177 176 178 235 222 217 216 215 214 213 212 211 133 MAP/microtubule affinity-regulating kinase 3
CAMK MELK MELK_HUMAN 4IXPA Q14680 2 335 651.0 No_ligand No_ligand Inactive DFGinter 8.337 8.22 BABtrans DFGAsp-rot-none -82.53, 111.66 -97.33, 24.09 999.0, 999.0 -131.73, 132.5 172.62, 90.1 -170.06, 168.41 out-none out 11.064 Saltbr-none 999.0 HRD-in -79.62, -62.46 77.21, 0.17 none-out-out SNCnoo out-out ActLoopNT-out 8.708 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -61.36, -24.12 APE9-dihe-na -60.42, -37.63 APE8-dihe-out -71.56, -9.7 APE8-rot-in 283.03 APE67-dihe-in -61.32, -17.74 -47.81, -52.79 APE12-dist-out 6.736 APE11-dist-out 7.657 APE10-dist-out 13.168 APE9-dist-out 11.076 K40R,D150A None None XRAY 2.749 0.202 0.232 A 348 334 0 0 0 0 [[11, 263]] 1.0 4ixp Homo sapiens CAMK_MELK_HUMAN CAMK 4.1e-86 294.6 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4UMTA Q14680 3 333 651.0 47W:1335 Type1 Inactive DFGinter 8.347 9.948 None DFGAsp-rot-in -125.65, -174.91 -147.25, 172.21 200.18, -3.34 77.11, 1.19 311.79, 155.98 -66.5, 145.33 out-out out 11.997 Saltbr-out 13.272 HRD-in -80.71, -59.49 79.99, -2.05 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, -17.83 APE9-dihe-na 40.69, -129.51 APE8-dihe-out -75.85, -1.01 APE8-rot-out 51.67 APE67-dihe-in -62.07, -20.63 -51.04, -41.03 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.174 APE9-dist-out 11.261 N213T,V214A,M215A,Y218V,K219A None None XRAY 1.98 0.214 0.236 A 356 316 15 0 0 15 [[11, 263]] 1.0 4umt Homo sapiens CAMK_MELK_HUMAN CAMK 4.6e-88 300.9 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK MELK MELK_HUMAN 4UMUA Q14680 3 333 651.0 0V0:1334 Type1 Inactive DFGinter 8.166 10.166 None DFGAsp-rot-in -116.79, -162.79 -155.72, 175.05 195.86, -0.92 72.46, 6.06 306.96, 157.96 -72.63, 148.48 out-out out 12.217 Saltbr-out 13.237 HRD-in -78.66, -59.93 79.02, -3.49 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 39.54 APE9-dihe-na 55.48, -131.65 APE8-dihe-out -79.5, 0.32 APE8-rot-out 30.81 APE67-dihe-in -69.91, -20.55 -51.25, -38.97 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.252 APE9-dist-out 11.079 None None None XRAY 2.02 0.207 0.236 A 356 316 15 0 0 15 [[11, 263]] 1.0 4umu Homo sapiens CAMK_MELK_HUMAN CAMK 4.6e-88 300.9 1 256 256 149 150 151 153 155 40 57 61 129 131 130 132 191 178 173 172 171 170 169 168 167 87 Maternal embryonic leucine zipper kinase
CAMK PRKAA1 AAPK1_HUMAN 4REDA Q13131 22 360 559.0 No_ligand No_ligand Inactive DFGinter 7.587 8.711 None DFGAsp-rot-in -76.34, -39.91 -91.25, 104.66 182.02, 10.76 -101.3, 16.59 55.39, 86.7 124.85, -0.24 out-out out 12.796 Saltbr-out 10.996 HRD-out -68.9, 144.23 -138.95, 122.97 out-out-out SNCooo out-out ActLoopNT-out 13.073 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 59.47 APE8-rot-out 66.53 APE67-dihe-out -120.17, 127.81 -69.82, 149.55 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K52A None None XRAY 2.95 0.233 0.277 A 351 326 13 0 0 9 [[27, 279]] 1.0 4red Homo sapiens CAMK_PRKAA1_HUMAN CAMK 5e-89 304.1 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK PRKAA1 AAPK1_HUMAN 4REDB Q13131 22 360 559.0 No_ligand No_ligand Inactive DFGinter 7.581 8.224 None DFGAsp-rot-in -76.53, -36.41 -94.12, 106.96 180.26, 5.35 -98.58, 14.09 52.09, 86.12 121.55, -8.46 out-out out 12.669 Saltbr-out 11.179 HRD-out -67.54, 143.84 -139.21, 124.67 out-out-out SNCooo out-out ActLoopNT-out 13.157 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -40.52 APE8-rot-out 68.01 APE67-dihe-in -131.1, -88.72 -74.35, 44.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 K52A None None XRAY 2.95 0.233 0.277 B 351 331 8 0 0 8 [[27, 279]] 1.0 4red Homo sapiens CAMK_PRKAA1_HUMAN CAMK 5e-89 304.1 1 256 256 167 168 169 171 173 56 75 79 147 149 148 150 207 194 189 188 187 186 185 184 183 105 5'-AMP-activated protein kinase catalytic subunit alpha-1
CAMK TRIB1 TRIB1_HUMAN 5CEKA Q96RU8 88 342 372.0 No_ligand No_ligand Pseudo DFGinter 8.858 7.037 None DFGAsp-rot-na -98.32, 87.14 -82.08, -7.36 59.01, 999.0 -109.34, 16.03 300.0, 168.59 61.59, 55.88 out-na out 12.089 Saltbr-na 999.0 HRD-in -75.72, -58.41 87.17, -43.21 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanao APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 124.18 APE8-rot-na 59.79 APE67-dihe-out 80.81, -50.83 -77.85, -164.87 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.8 0.209 0.246 A 263 237 18 0 0 13 [[99, 338]] 1.0 5cek Homo sapiens CAMK_TRIB1_HUMAN CAMK 9.2e-62 214.7 14 256 243 224 225 226 228 230 120 130 134 202 204 203 205 266 252 247 246 245 244 243 242 241 161 Tribbles homolog 1
CAMK TRIB1 TRIB1_HUMAN 5CEMA Q96RU8 88 364 372.0 No_ligand No_ligand Pseudo DFGinter 9.487 6.83 None DFGAsp-rot-na -85.06, 104.77 -111.16, 5.29 66.22, 999.0 -105.21, 15.47 300.28, 1.5 60.7, 52.63 out-na out 12.027 Saltbr-na 999.0 HRD-in -82.52, -54.12 78.21, -13.8 na-none-out SNCano none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiao APEdist_oooo APE10-dihe-na -58.19, 148.96 APE9-dihe-na 66.07, 47.38 APE8-dihe-in -82.13, 123.37 APE8-rot-na 180.29 APE67-dihe-out -72.24, -16.3 -74.98, 72.26 APE12-dist-out 26.802 APE11-dist-out 24.692 APE10-dist-out 20.205 APE9-dist-out 15.941 None None None XRAY 2.1 0.179 0.223 A 292 252 11 0 0 9 [[99, 338]] 1.0 5cem Homo sapiens CAMK_TRIB1_HUMAN CAMK 1.3e-61 214.2 14 256 243 224 225 226 228 230 120 130 134 202 204 203 205 266 252 247 246 245 244 243 242 241 161 Tribbles homolog 1
CMGC MAPK14 MK14_HUMAN 4EH9A Q16539 5 354 360.0 IRG:401,0OQ:402 Allosteric,Type3 Inactive DFGinter 10.9 6.206 None DFGAsp-rot-out -97.42, 159.57 -62.33, -60.46 47.45, -4.82 -150.13, 147.17 64.11, 82.71 -78.55, 25.4 in-out in 9.404 Saltbr-out 4.576 HRD-in -71.05, -53.71 82.13, -21.54 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 115.29 APE9-dihe-na -99.26, 134.28 APE8-dihe-out -59.4, -32.47 APE8-rot-in 294.18 APE67-dihe-in -64.19, -25.37 -57.95, -25.13 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 12.356 APE9-dist-out 11.824 None None None XRAY 2.1 0.232 0.28 A 360 334 16 0 0 11 [[24, 308]] 1.0 4eh9 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.1e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3GCPA Q16539 4 352 360.0 SB2:361 Type1 Inactive DFGinter 10.471 9.26 None DFGAsp-rot-out -117.37, 167.72 -120.22, 32.97 66.16, -16.65 -153.57, 150.38 52.4, 89.27 -67.24, 116.69 in-in in 9.161 Saltbr-in 2.949 HRD-in -63.02, -55.34 82.04, -15.88 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 176.81 APE8-rot-out 58.62 APE67-dihe-in -63.93, -20.89 -120.85, 2.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 C119S,C162S,A172C,F327L None None XRAY 2.25 0.201 0.276 A 360 337 12 0 0 12 [[24, 308]] 1.0 3gcp Homo sapiens CMGC_MAPK14_HUMAN CMGC 4.5e-84 288.3 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 5WJJA Q16539 5 352 360.0 AQY:501 Type1 Inactive DFGinter 10.159 9.062 None DFGAsp-rot-out -113.52, 161.05 -110.02, 23.38 53.99, 6.8 -151.72, 163.67 53.5, 90.99 -95.62, 149.45 in-in in 9.566 Saltbr-in 3.445 HRD-in -66.13, -48.01 74.38, -15.21 in-out-out SNCioo out-out ActLoopNT-out 22.96 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 151.37 APE8-dihe-out -54.87, -43.06 APE8-rot-in 316.01 APE67-dihe-in -61.84, -23.7 -56.22, -24.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.145 None None None XRAY 1.6 0.202 0.237 A 365 338 10 0 0 6 [[24, 308]] 1.0 5wjj Homo sapiens CMGC_MAPK14_HUMAN CMGC 8.7e-85 290.6 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 6ANLA Q16539 4 352 360.0 T75:401 Type1 Inactive DFGinter 8.702 9.562 None DFGAsp-rot-out -112.8, 165.91 -107.34, -21.64 285.55, -32.39 -131.97, 3.35 36.97, 78.14 70.96, -173.34 in-in in 9.931 Saltbr-in 3.589 HRD-in -64.58, -50.49 75.67, -10.04 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 173.9 APE8-dihe-out -67.0, -31.89 APE8-rot-in 294.98 APE67-dihe-in -56.18, -24.82 -62.08, -27.15 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.877 C119S,C162S None None XRAY 2.0 0.209 0.263 A 365 338 11 0 0 11 [[24, 308]] 1.0 6anl Homo sapiens CMGC_MAPK14_HUMAN CMGC 8.7e-85 290.6 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 5ML5A Q16539 5 352 360.0 1VI:404 Type1 Inactive DFGinter 10.136 9.242 None DFGAsp-rot-out -111.39, 159.42 -109.35, 34.77 62.79, -17.83 -164.27, 172.15 56.08, 84.45 -90.56, 999.0 in-in in 9.333 Saltbr-in 2.606 HRD-in -70.95, -52.33 83.04, -10.08 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 141.66 APE8-rot-in 289.06 APE67-dihe-in -53.62, -25.52 -105.11, -4.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.9 0.195 0.24 A 360 326 22 0 0 14 [[24, 308]] 1.0 5ml5 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.1e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3HUCA Q16539 4 352 360.0 G97:362 Type1 Inactive DFGinter 10.337 9.179 None DFGAsp-rot-out -109.97, 165.2 -105.06, 29.04 56.85, -20.61 179.24, 164.7 62.51, 85.01 -109.68, 999.0 in-in in 9.553 Saltbr-in 2.442 HRD-in -73.07, -53.68 79.88, -13.18 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnno APE10-dihe-na 999.0, 145.84 APE9-dihe-na -130.77, 137.71 APE8-dihe-out -61.1, -31.75 APE8-rot-in 284.73 APE67-dihe-in -65.27, -22.19 -58.7, -25.74 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 12.125 None None None XRAY 1.8 0.196 0.232 A 360 337 12 0 0 12 [[24, 308]] 1.0 3huc Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.1e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3ZS5A Q16539 2 352 360.0 SB2:61000 Type1 Inactive DFGinter 10.234 9.251 None DFGAsp-rot-out -115.27, 172.44 -122.64, 34.9 57.7, -14.42 -156.58, 162.56 53.94, 87.63 -91.34, 146.87 in-in in 9.437 Saltbr-in 2.826 HRD-in -66.65, -51.78 79.0, -9.81 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -29.47 APE8-dihe-out -65.94, -20.08 APE8-rot-out 57.11 APE67-dihe-in -60.59, -17.67 -110.97, -2.6 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.437 None None None XRAY 1.6 0.186 0.215 A 362 339 12 0 0 12 [[24, 308]] 1.0 3zs5 Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 3ZSGA Q16539 4 352 360.0 T75:400 Type1 Inactive DFGinter 9.869 9.382 None DFGAsp-rot-out -112.39, 162.65 -112.67, 28.78 61.03, -15.39 -156.41, 165.54 53.67, 85.81 -94.27, 155.51 in-in in 9.817 Saltbr-in 3.405 HRD-in -65.93, -52.33 82.35, -11.55 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -19.16 APE8-dihe-out -64.72, -27.97 APE8-rot-out 56.05 APE67-dihe-in -62.96, -19.39 -109.94, 3.08 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.409 None None None XRAY 1.89 0.191 0.233 A 362 337 12 0 0 12 [[24, 308]] 1.0 3zsg Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 6HWTA Q16539 5 352 360.0 GXH:404 Type1 Inactive DFGinter 9.606 9.249 None DFGAsp-rot-out -109.85, 163.34 -111.83, 32.01 63.66, -21.63 -158.93, 166.76 53.05, 86.7 -101.84, 157.19 in-in in 9.405 Saltbr-in 3.166 HRD-in -68.48, -52.76 78.69, -12.38 in-out-out SNCioo out-out ActLoopNT-out 23.197 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 160.58 APE8-rot-out 199.92 APE67-dihe-in -66.05, -17.36 -114.13, 10.53 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.204 0.234 A 362 336 12 0 0 11 [[24, 308]] 1.0 6hwt Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 6HWUA Q16539 5 353 360.0 GE5:404 Type1 Inactive DFGinter 9.59 8.968 None DFGAsp-rot-out -118.08, 168.42 -117.72, 42.58 63.49, -18.87 -170.41, 161.53 57.41, 87.05 -97.74, 161.01 in-in in 9.458 Saltbr-in 2.926 HRD-in -69.49, -51.73 75.06, -4.67 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 73.5 APE9-dihe-na -65.73, 137.2 APE8-dihe-out -60.1, -34.07 APE8-rot-in 274.51 APE67-dihe-in -66.54, -24.29 -62.93, -25.28 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 11.207 APE9-dist-out 11.553 None None None XRAY 2.3 0.193 0.247 A 362 333 16 0 0 11 [[24, 308]] 1.0 6hwu Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 6HWVA Q16539 5 352 360.0 GEW:404 Type1 Inactive DFGinter 9.996 9.286 None DFGAsp-rot-out -112.84, 163.83 -110.3, 35.34 60.19, -23.19 -165.77, 166.95 54.01, 85.28 -99.22, 157.29 in-in in 9.494 Saltbr-in 2.804 HRD-in -69.21, -52.62 80.0, -9.79 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 138.66 APE8-rot-out 177.65 APE67-dihe-in -67.08, -18.22 -107.78, 6.47 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.7 0.18 0.197 A 362 336 12 0 0 12 [[24, 308]] 1.0 6hwv Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.2e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK14 MK14_HUMAN 4EHVA Q16539 5 352 360.0 0SJ:401,0SJ:402,IRG:403,0SJ:404 Type3,Allosteric,Allosteric,Allosteric Inactive DFGinter 10.923 6.276 None DFGAsp-rot-out -99.66, 162.35 -69.64, -55.96 48.23, -19.84 -152.93, 157.53 62.39, 91.72 -108.25, -179.88 in-none in 9.237 Saltbr-none 999.0 HRD-in -69.34, -50.13 82.95, -13.29 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 107.52 APE9-dihe-na -78.18, 127.1 APE8-dihe-out -52.4, -41.18 APE8-rot-in 282.24 APE67-dihe-in -64.93, -23.91 -55.78, -30.86 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.946 APE9-dist-out 11.005 None None None XRAY 1.6 0.223 0.252 A 360 337 11 0 0 11 [[24, 308]] 1.0 4ehv Homo sapiens CMGC_MAPK14_HUMAN CMGC 6.1e-85 291.1 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
CMGC MAPK6 MK06_HUMAN 6YKYA Q16659 18 319 721.0 OWQ:401 Type1 Inactive DFGinter 8.827 5.003 None DFGAsp-rot-out -71.78, 144.73 -71.1, -32.64 295.94, -83.34 -79.99, 115.19 311.82, 124.02 127.81, -16.19 in-out in 9.812 Saltbr-out 8.13 HRD-out -111.51, 110.19 -70.61, -5.41 out-out-out SNCooo out-out ActLoopNT-out 5.241 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -91.65, 9.39 APE9-dihe-na -95.19, 123.93 APE8-dihe-in -73.44, 137.77 APE8-rot-out 188.34 APE67-dihe-in -47.48, -36.76 -86.99, -20.14 APE12-dist-out 18.651 APE11-dist-out 20.197 APE10-dist-out 17.841 APE9-dist-out 8.26 L290V None None XRAY 2.52 0.201 0.251 A 319 281 21 0 0 9 [[20, 316]] 1.0 6yky Homo sapiens CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1 301 301 170 171 172 174 176 49 65 69 149 151 150 152 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
CMGC MAPK6 MK06_HUMAN 6YKYD Q16659 14 321 721.0 OWQ:401 Type1 Inactive DFGinter 10.483 4.783 None DFGAsp-rot-out -79.21, 142.3 -63.95, -30.02 305.87, -78.29 -82.92, 88.96 326.01, 122.38 148.68, -14.44 out-out out 13.329 Saltbr-out 11.755 HRD-out -97.47, 116.92 -79.67, -2.76 out-out-out SNCooo out-out ActLoopNT-out 5.246 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -102.9, -29.99 APE9-dihe-na -87.22, 152.15 APE8-dihe-in -86.08, 134.07 APE8-rot-out 192.13 APE67-dihe-in -46.65, -35.13 -86.31, -21.98 APE12-dist-out 20.076 APE11-dist-out 21.384 APE10-dist-out 18.132 APE9-dist-out 8.938 L290V None None XRAY 2.52 0.201 0.251 D 319 301 7 0 0 0 [[20, 316]] 1.0 6yky Homo sapiens CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1 301 301 170 171 172 174 176 49 65 69 149 151 150 152 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
CMGC MAPK6 MK06_HUMAN 6YLCD Q16659 13 321 721.0 OXW:401 Type1 Inactive DFGinter 9.834 4.994 None DFGAsp-rot-out -68.6, 151.66 -80.4, -20.68 303.66, -74.94 -82.11, 114.82 290.44, 97.57 115.85, -9.5 out-out out 13.347 Saltbr-out 9.853 HRD-out -103.81, 118.3 -82.36, -0.96 out-out-out SNCooo out-out ActLoopNT-out 5.362 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -102.61, -26.31 APE9-dihe-na -98.13, 139.46 APE8-dihe-in -69.39, 130.27 APE8-rot-out 191.58 APE67-dihe-in -59.56, -27.81 -93.33, -5.47 APE12-dist-out 19.987 APE11-dist-out 21.389 APE10-dist-out 18.196 APE9-dist-out 9.055 L290V None None XRAY 2.43 0.191 0.231 D 319 303 6 0 0 0 [[20, 316]] 1.0 6ylc Homo sapiens CMGC_MAPK6_HUMAN CMGC 2.1e-74 256.5 1 301 301 170 171 172 174 176 49 65 69 149 151 150 152 214 201 196 195 194 193 192 191 190 109 Mitogen-activated protein kinase 6
NEK NEK1 NEK1_HUMAN 4APCA Q96PY6 1 284 1258.0 No_ligand No_ligand Inactive DFGinter 9.644 5.999 BABtrans DFGAsp-rot-in -56.67, 136.95 -74.99, -38.65 199.33, 2.06 -62.93, 130.11 204.86, 72.11 112.63, -15.33 out-none out 11.485 Saltbr-none 999.0 HRD-out -132.48, 108.44 -75.85, -8.05 none-out-out SNCnoo out-out ActLoopNT-out 5.359 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -88.83, -42.36 APE9-dihe-na -95.57, -114.29 APE8-dihe-in -105.03, 125.23 APE8-rot-in 310.11 APE67-dihe-in -73.53, -9.9 -94.81, -5.15 APE12-dist-out 15.971 APE11-dist-out 20.733 APE10-dist-out 18.867 APE9-dist-out 10.432 T162A None None XRAY 2.1 0.216 0.248 A 350 278 6 0 0 0 [[4, 258]] 1.0 4apc Homo sapiens NEK_NEK1_HUMAN NEK 2.1e-117 397.3 1 256 256 145 146 147 149 151 33 51 55 125 127 126 128 185 173 168 167 166 165 164 163 162 81 Serine/threonine-protein kinase Nek1
NEK NEK1 NEK1_HUMAN 4APCB Q96PY6 1 284 1258.0 No_ligand No_ligand Inactive DFGinter 9.552 6.103 BABtrans DFGAsp-rot-out -57.58, 134.02 -75.98, -33.46 49.16, -42.5 -60.99, 130.52 202.95, 70.38 110.42, -15.38 out-out out 11.732 Saltbr-out 12.877 HRD-out -131.41, 107.06 -74.49, -7.52 out-out-out SNCooo out-out ActLoopNT-out 5.352 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -75.97, -42.82 APE9-dihe-na -96.64, -115.4 APE8-dihe-in -106.78, 122.56 APE8-rot-in 310.29 APE67-dihe-in -74.36, -7.84 -93.49, -5.36 APE12-dist-out 15.877 APE11-dist-out 20.629 APE10-dist-out 18.814 APE9-dist-out 10.411 T162A None None XRAY 2.1 0.216 0.248 B 350 279 5 0 0 0 [[4, 258]] 1.0 4apc Homo sapiens NEK_NEK1_HUMAN NEK 2.1e-117 397.3 1 256 256 145 146 147 149 151 33 51 55 125 127 126 128 185 173 168 167 166 165 164 163 162 81 Serine/threonine-protein kinase Nek1
NEK NEK1 NEK1_HUMAN 4B9DA Q96PY6 1 284 1258.0 CK7:61285 Type1 Inactive DFGinter 10.305 6.08 BABtrans DFGAsp-rot-out -64.94, 139.98 -87.18, -44.3 53.04, -37.7 -54.24, 126.06 193.16, 81.64 121.24, -18.42 out-none out 11.54 Saltbr-none 999.0 HRD-out -117.2, 113.34 -81.68, 1.37 none-out-out SNCnoo out-out ActLoopNT-out 5.164 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -97.21, -40.86 APE9-dihe-na -102.37, -129.43 APE8-dihe-in -86.61, 121.95 APE8-rot-in 319.16 APE67-dihe-in -71.65, -10.17 -95.47, -0.6 APE12-dist-out 16.151 APE11-dist-out 20.776 APE10-dist-out 18.774 APE9-dist-out 10.678 T162A None None XRAY 1.9 0.196 0.222 A 350 278 6 0 0 0 [[4, 258]] 1.0 4b9d Homo sapiens NEK_NEK1_HUMAN NEK 2.1e-117 397.3 1 256 256 145 146 147 149 151 33 51 55 125 127 126 128 185 173 168 167 166 165 164 163 162 81 Serine/threonine-protein kinase Nek1
NEK NEK1 NEK1_HUMAN 4B9DB Q96PY6 1 284 1258.0 CK7:61285 Type1 Inactive DFGinter 10.476 6.148 BABtrans DFGAsp-rot-out -65.92, 139.98 -87.45, -46.22 51.7, -37.83 -48.38, 128.7 190.39, 78.79 118.23, -19.27 out-out out 11.665 Saltbr-out 11.609 HRD-out -108.39, 113.36 -82.3, 1.28 out-out-out SNCooo out-out ActLoopNT-out 5.061 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -82.88, -40.18 APE9-dihe-na -104.73, -128.22 APE8-dihe-in -88.79, 124.64 APE8-rot-in 318.31 APE67-dihe-in -72.39, -9.41 -95.66, -1.52 APE12-dist-out 16.136 APE11-dist-out 20.69 APE10-dist-out 18.673 APE9-dist-out 10.702 T162A None None XRAY 1.9 0.196 0.222 B 350 279 5 0 0 0 [[4, 258]] 1.0 4b9d Homo sapiens NEK_NEK1_HUMAN NEK 2.1e-117 397.3 1 256 256 145 146 147 149 151 33 51 55 125 127 126 128 185 173 168 167 166 165 164 163 162 81 Serine/threonine-protein kinase Nek1
NEK NEK2 NEK2_HUMAN 2W5BA P51955 3 271 445.0 AGS:61280 ATPlike Inactive DFGinter 8.504 5.693 None DFGAsp-rot-in -133.84, 63.71 -87.34, 106.84 174.71, -0.91 -95.06, 50.42 207.49, 72.2 -49.75, -30.44 out-out out 12.589 Saltbr-out 12.763 HRD-out -82.64, 121.7 -138.12, 47.77 out-out-out SNCooo out-out ActLoopNT-out 12.438 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -74.41, -42.54 APE9-dihe-na -62.33, 153.14 APE8-dihe-in -108.21, 120.03 APE8-rot-in 313.31 APE67-dihe-out -53.46, -34.47 -75.96, 66.07 APE12-dist-out 14.06 APE11-dist-out 18.785 APE10-dist-out 19.398 APE9-dist-out 15.879 T175A None None XRAY 2.4 0.186 0.245 A 279 263 6 0 0 0 [[8, 271]] 1.0 2w5b Homo sapiens NEK_NEK2_HUMAN NEK 3.5e-109 370.2 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
NEK NEK2 NEK2_HUMAN 2W5HA P51955 3 271 445.0 No_ligand No_ligand Inactive DFGinter 8.853 5.406 None DFGAsp-rot-in -145.64, 64.76 -76.5, 122.71 177.47, -12.06 -111.22, 47.01 200.36, 74.35 -55.33, -23.57 out-none out 12.526 Saltbr-none 999.0 HRD-none 999.0, 88.49 -140.73, 52.97 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_iooo APE10-dihe-na -80.98, -33.57 APE9-dihe-na -66.5, 141.66 APE8-dihe-in -95.51, 126.28 APE8-rot-in 311.21 APE67-dihe-out -49.54, -31.25 -80.26, 60.18 APE12-dist-in 13.999 APE11-dist-out 18.643 APE10-dist-out 19.67 APE9-dist-out 16.136 T175A None None XRAY 2.33 0.197 0.254 A 279 257 12 0 0 3 [[8, 271]] 1.0 2w5h Homo sapiens NEK_NEK2_HUMAN NEK 3.5e-109 370.2 1 256 256 158 159 160 162 164 37 55 59 138 140 139 141 198 186 181 180 179 178 177 176 175 87 Serine/threonine-protein kinase Nek2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKH Q9P2K8 584 1006 1649.0 G41:1701 Type1 Inactive DFGinter 8.046 8.437 BABtrans DFGAsp-rot-out -55.61, 130.2 -124.52, 16.67 43.76, 6.34 -106.93, 111.28 188.62, 73.34 126.77, 18.12 out-out out 11.056 Saltbr-out 7.626 HRD-in -81.65, -56.1 78.04, -22.14 out-out-out SNCooo out-out ActLoopNT-out 5.295 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_oooo APE10-dihe-na -63.36, -44.68 APE9-dihe-na -61.4, -37.94 APE8-dihe-out -73.72, -24.45 APE8-rot-none 999.0 APE67-dihe-in -74.17, -2.36 -79.69, -19.77 APE12-dist-out 22.363 APE11-dist-out 21.053 APE10-dist-out 23.953 APE9-dist-out 13.506 D848N None None XRAY 2.3 0.214 0.243 H 318 259 38 0 0 19 [[277, 541], [590, 1001]] 2.0 7qwk Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.2e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER EIF2AK4-2 E2AK4_HUMAN 7QWKF Q9P2K8 584 1005 1649.0 G41:1701 Type1 Inactive DFGinter 8.037 8.181 None DFGAsp-rot-out -60.18, 141.19 -134.64, 94.13 42.41, 13.86 -155.09, 69.13 206.23, 33.34 148.0, 161.57 out-out out 11.114 Saltbr-out 8.211 HRD-in -90.54, -49.57 66.47, -5.34 out-out-out SNCooo out-out ActLoopNT-out 6.628 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_oooo APE10-dihe-na 134.32, -54.28 APE9-dihe-na -62.87, -46.85 APE8-dihe-out -62.12, -35.02 APE8-rot-none 999.0 APE67-dihe-in -70.96, -4.61 -71.45, -20.51 APE12-dist-out 23.468 APE11-dist-out 21.748 APE10-dist-out 24.316 APE9-dist-out 13.581 D848N None None XRAY 2.3 0.214 0.243 F 318 254 42 0 0 24 [[277, 541], [590, 1001]] 2.0 7qwk Homo sapiens OTHER_EIF2AK4-2_HUMAN OTHER 2.2e-46 164.7 1 256 256 865 866 867 869 871 619 636 640 845 847 846 848 925 911 906 905 904 903 902 901 900 803 eIF-2-alpha kinase GCN2
OTHER IKBKB IKKB_HUMAN 8OMVE O14920 9 643 756.0 No_ligand No_ligand Inactive DFGinter 7.536 10.902 None DFGAsp-rot-in -105.5, 166.4 59.46, 69.27 196.57, 16.99 -69.45, 93.59 281.39, 127.96 -78.86, -65.73 in-out in 9.168 Saltbr-out 4.713 HRD-in -72.45, -37.03 70.29, -11.28 out-out-out SNCooo out-out ActLoopNT-out 4.682 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_iiio APE10-dihe-na -157.14, 127.84 APE9-dihe-na -150.61, -127.8 APE8-dihe-out -138.47, -162.6 APE8-rot-out 59.63 APE67-dihe-in -96.12, -64.95 -135.66, 0.49 APE12-dist-in 9.551 APE11-dist-in 11.201 APE10-dist-in 7.793 APE9-dist-out 7.897 S177E,S181E None None XRAY 4.16 0.259 0.299 E 671 566 10 0 0 3 [[15, 449]] 1.0 8omv Homo sapiens OTHER_IKBKB_HUMAN OTHER 2.6e-50 178.5 1 249 249 165 166 167 169 171 44 61 65 142 144 143 145 204 192 187 186 185 184 183 182 181 97 Inhibitor of nuclear factor kappa-B kinase subunit beta
STE MAP2K1 MP2K1_HUMAN 5YT3A Q02750 39 382 393.0 ANP:401 ATPlike Inactive DFGinter 6.357 10.383 None DFGAsp-rot-out -128.68, 173.26 63.68, 38.66 290.85, -58.72 -52.93, -21.76 28.6, 36.22 -61.84, 114.84 out-out out 16.315 Saltbr-out 14.589 HRD-in -77.7, -42.23 58.41, 13.61 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 70.97 APE8-rot-none 999.0 APE67-dihe-out -132.4, 139.8 -149.07, 91.78 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S218D,S222D,T292A,S298A None None XRAY 2.9 0.213 0.289 A 350 297 47 0 0 14 [[68, 361]] 1.0 5yt3 Homo sapiens STE_MAP2K1_HUMAN STE 4.9e-97 330.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP3K5 M3K5_HUMAN 2CLQA Q99683 670 940 1374.0 STU:1941 Type1 Inactive DFGinter 5.918 8.469 BABtrans DFGAsp-rot-out -91.39, 129.8 -141.56, 7.65 76.17, -45.04 -79.81, 110.16 226.87, 94.37 134.88, -46.11 out-out out 10.127 Saltbr-out 4.796 HRD-in -81.27, -49.85 78.55, 0.8 out-in-out SNCoio in-out ActLoopNT-in 3.025 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -136.64, 134.41 APE9-dihe-na -79.2, -159.26 APE8-dihe-in -79.76, 137.19 APE8-rot-in 323.06 APE67-dihe-in -73.67, -16.9 -62.96, -40.27 APE12-dist-in 11.61 APE11-dist-out 6.223 APE10-dist-out 10.04 APE9-dist-in 3.702 None None None XRAY 2.3 0.204 0.257 A 295 263 8 0 0 5 [[678, 938]] 1.0 2clq Homo sapiens STE_MAP3K5_HUMAN STE 6.1e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP3K5 M3K5_HUMAN 2CLQB Q99683 670 940 1374.0 STU:1941 Type1 Inactive DFGinter 6.564 8.021 BABtrans DFGAsp-rot-out -97.55, 126.7 -140.68, 10.18 80.97, -70.46 -79.54, 109.54 215.05, 109.45 130.73, -46.4 in-none in 9.98 Saltbr-none 999.0 HRD-in -83.48, -49.36 79.39, -1.77 none-in-out SNCnio in-out ActLoopNT-in 3.001 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -136.24, 136.94 APE9-dihe-na -82.54, -165.1 APE8-dihe-in -71.26, 138.19 APE8-rot-in 313.5 APE67-dihe-in -70.89, -23.23 -61.89, -43.74 APE12-dist-none 999.0 APE11-dist-out 6.267 APE10-dist-out 10.013 APE9-dist-in 3.749 None None None XRAY 2.3 0.204 0.257 B 295 259 12 0 0 8 [[678, 938]] 1.0 2clq Homo sapiens STE_MAP3K5_HUMAN STE 6.1e-81 277.6 5 257 253 821 822 823 825 827 709 725 729 800 802 801 803 863 849 844 843 842 841 840 839 838 755 Mitogen-activated protein kinase kinase kinase 5
STE MAP4K1 M4K1_HUMAN 9BI8A Q92918 6 293 833.0 A1APL:60301 Type1 Inactive DFGinter 10.88 6.392 None DFGAsp-rot-in -84.61, 129.22 -97.99, 100.09 180.71, 4.32 -110.18, 33.34 298.01, 131.21 -69.67, 73.48 out-out out 13.764 Saltbr-out 14.074 HRD-in -72.89, -53.57 81.64, -15.14 out-out-out SNCooo out-out ActLoopNT-out 12.228 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -88.01, -22.61 APE9-dihe-na 97.47, -162.62 APE8-dihe-in -70.31, 141.95 APE8-rot-out 187.73 APE67-dihe-in -58.8, -30.03 -104.05, -8.58 APE12-dist-out 20.556 APE11-dist-out 20.704 APE10-dist-out 21.839 APE9-dist-out 20.928 None None None XRAY 2.25 0.203 0.271 A 311 288 0 0 0 0 [[17, 274]] 1.0 9bi8 Homo sapiens STE_MAP4K1_HUMAN STE 5.2e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9BI8B Q92918 6 293 833.0 A1APL:60302 Type1 Inactive DFGinter 10.74 6.23 None DFGAsp-rot-in -97.5, 135.14 -108.73, 95.26 182.29, 9.22 -106.77, 39.31 297.68, 134.76 -83.18, 62.11 out-out out 13.997 Saltbr-out 14.039 HRD-in -72.45, -53.25 76.92, -14.23 out-out-out SNCooo out-out ActLoopNT-out 12.839 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -130.02, -27.74 APE9-dihe-na 93.81, 172.9 APE8-dihe-in -65.36, 145.02 APE8-rot-out 198.59 APE67-dihe-in -58.71, -28.43 -102.52, -7.42 APE12-dist-out 22.486 APE11-dist-out 22.102 APE10-dist-out 20.6 APE9-dist-out 22.057 None None None XRAY 2.25 0.203 0.271 B 311 288 0 0 0 0 [[17, 274]] 1.0 9bi8 Homo sapiens STE_MAP4K1_HUMAN STE 5.2e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9N9XA Q92918 6 293 833.0 A1BWL:60303 Type1 Inactive DFGinter 10.661 6.351 None DFGAsp-rot-in -84.76, 134.66 -105.03, 107.01 176.48, 6.62 -114.17, 28.48 294.9, 125.35 -58.6, 75.75 out-out out 13.958 Saltbr-out 13.908 HRD-in -69.29, -54.46 84.81, -14.35 out-out-out SNCooo out-out ActLoopNT-out 12.469 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -81.99, -16.32 APE9-dihe-na 85.41, -173.0 APE8-dihe-in -61.5, 138.0 APE8-rot-out 189.55 APE67-dihe-in -57.89, -33.43 -97.6, -11.25 APE12-dist-out 20.846 APE11-dist-out 20.756 APE10-dist-out 21.579 APE9-dist-out 20.677 None None None XRAY 2.3 0.227 0.276 A 311 288 0 0 0 0 [[17, 274]] 1.0 9n9x Homo sapiens STE_MAP4K1_HUMAN STE 5.2e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K1 M4K1_HUMAN 9N9XB Q92918 5 293 833.0 A1BWL:60303 Type1 Inactive DFGinter 10.659 6.162 None DFGAsp-rot-in -80.37, 148.27 -120.58, 99.48 174.61, 9.38 -108.65, 34.73 297.74, 123.66 -67.08, 76.96 out-out out 14.045 Saltbr-out 13.883 HRD-in -72.97, -55.95 86.29, -23.53 out-out-out SNCooo out-out ActLoopNT-out 13.033 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -142.31, -31.43 APE9-dihe-na 78.86, 177.37 APE8-dihe-in -56.88, 138.49 APE8-rot-out 57.19 APE67-dihe-in -66.47, -29.19 -92.99, -1.5 APE12-dist-out 21.885 APE11-dist-out 21.794 APE10-dist-out 20.426 APE9-dist-out 22.322 None None None XRAY 2.3 0.227 0.276 B 311 289 0 0 0 0 [[17, 274]] 1.0 9n9x Homo sapiens STE_MAP4K1_HUMAN STE 5.2e-92 313.8 1 256 256 154 155 156 158 160 46 62 66 134 136 135 137 197 182 177 176 175 174 173 172 171 92 Mitogen-activated protein kinase kinase kinase kinase 1
STE MAP4K4 M4K4_HUMAN 4U3ZA O95819 17 311 1239.0 No_ligand No_ligand Inactive DFGinter 5.504 10.108 None DFGAsp-rot-in -90.3, 128.59 75.45, 163.28 206.87, -10.07 -151.97, 31.14 43.16, 85.73 119.13, -6.79 out-out out 13.995 Saltbr-out 13.772 HRD-in -72.3, -49.26 78.71, -16.24 out-out-out SNCooo out-out ActLoopNT-out 5.305 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -98.57, 126.67 APE9-dihe-na -83.8, -149.21 APE8-dihe-in -69.81, 136.64 APE8-rot-out 191.8 APE67-dihe-in -65.68, -25.19 -91.82, -5.09 APE12-dist-out 18.044 APE11-dist-out 17.229 APE10-dist-out 18.461 APE9-dist-out 9.95 T181E None None XRAY 2.09 0.186 0.249 A 332 282 13 0 0 0 [[25, 289]] 1.0 4u3z Homo sapiens STE_MAP4K4_HUMAN STE 2.3e-102 347.7 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
STE MAP4K4 M4K4_HUMAN 4U3YA O95819 17 311 1239.0 No_ligand No_ligand Inactive DFGinter 5.685 10.295 None DFGAsp-rot-in -88.99, 126.24 79.22, 151.13 204.2, -2.83 -137.58, 35.87 48.82, 95.81 105.67, -5.01 out-out out 13.903 Saltbr-out 14.441 HRD-in -83.26, -53.16 70.55, 5.66 out-out-out SNCooo out-out ActLoopNT-out 5.766 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -69.98, -47.61 APE9-dihe-na 95.3, -170.42 APE8-dihe-in -81.29, 138.53 APE8-rot-out 188.11 APE67-dihe-in -65.33, -22.86 -89.45, -12.96 APE12-dist-out 15.771 APE11-dist-out 17.308 APE10-dist-out 19.317 APE9-dist-out 9.836 None None None XRAY 1.45 0.184 0.207 A 332 295 0 0 0 0 [[25, 289]] 1.0 4u3y Homo sapiens STE_MAP4K4_HUMAN STE 1.8e-102 348.1 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 Mitogen-activated protein kinase kinase kinase kinase 4
STE PAK1 PAK1_HUMAN 9D50B Q13153 253 542 545.0 A1A2T:601 Type1 Inactive DFGinter 7.208 7.932 None DFGAsp-rot-out -130.13, 169.98 -108.02, 0.22 276.95, -53.87 -119.5, 17.11 301.73, 104.49 -81.4, -34.77 in-out in 9.987 Saltbr-out 5.352 HRD-in -71.88, -57.66 86.42, -21.48 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiio APEdist_oooo APE10-dihe-na -63.89, -52.65 APE9-dihe-na -113.94, 174.61 APE8-dihe-in -89.03, 125.57 APE8-rot-in 304.08 APE67-dihe-out -69.25, -19.69 -82.71, 72.13 APE12-dist-out 20.154 APE11-dist-out 16.264 APE10-dist-out 13.821 APE9-dist-out 13.703 D389N,T423E None None XRAY 1.898 0.186 0.23 B 296 275 15 0 0 8 [[270, 521]] 1.0 9d50 Homo sapiens STE_PAK1_HUMAN STE 3.4e-94 321.0 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE SLK SLK_HUMAN 4USFA Q9H2G2 19 310 1235.0 6UI:60700 Type1 Inactive DFGinter 8.042 10.058 None DFGAsp-rot-in -117.97, -164.7 -148.31, 161.25 199.82, -1.05 67.07, 10.53 308.47, 138.36 -64.12, 155.64 out-out out 12.27 Saltbr-out 11.521 HRD-in -81.47, -50.79 75.66, -10.69 out-out-out SNCooo out-out ActLoopNT-out 20.081 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 124.78 APE8-rot-in 310.95 APE67-dihe-out -63.58, -25.56 -87.14, 59.37 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.75 0.198 0.228 A 304 275 17 0 0 13 [[34, 292]] 1.0 4usf Homo sapiens STE_SLK_HUMAN STE 9e-97 329.4 1 257 257 172 173 174 176 178 63 79 83 152 154 153 155 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
STE SLK SLK_HUMAN 4USFB Q9H2G2 19 310 1235.0 6UI:60700 Type1 Inactive DFGinter 8.38 9.95 None DFGAsp-rot-in -116.24, -167.43 -147.44, 163.23 196.78, 2.43 64.7, 16.11 306.44, 141.27 -69.71, 155.48 out-out out 11.908 Saltbr-out 10.492 HRD-in -81.17, -51.97 77.33, -10.55 out-out-out SNCooo out-out ActLoopNT-out 19.963 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nooi APE10-dihe-na -129.76, 123.16 APE9-dihe-na 56.23, 51.46 APE8-dihe-in -52.62, 128.43 APE8-rot-in 306.51 APE67-dihe-in -63.75, -23.49 -58.2, -37.55 APE12-dist-none 999.0 APE11-dist-out 7.804 APE10-dist-out 11.968 APE9-dist-in 3.518 None None None XRAY 1.75 0.198 0.228 B 304 283 9 0 0 9 [[34, 292]] 1.0 4usf Homo sapiens STE_SLK_HUMAN STE 9e-97 329.4 1 257 257 172 173 174 176 178 63 79 83 152 154 153 155 217 200 195 194 193 192 191 190 189 109 STE20-like serine/threonine-protein kinase
STE STK25 STK25_HUMAN 4NZWB O00506 11 292 426.0 J60:1000 Type1 Inactive DFGinter 10.262 5.963 None DFGAsp-rot-none -75.42, -140.49 -158.88, -45.92 999.0, 999.0 -65.17, 119.32 317.26, 111.8 114.04, -12.12 out-out out 10.07 Saltbr-out 4.302 HRD-in -77.57, -31.02 67.3, -14.73 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -73.59 APE8-dihe-out 136.85, 83.49 APE8-rot-out 37.4 APE67-dihe-in -19.17, -28.72 -28.03, -93.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 4.737 D158A None None XRAY 3.583 0.214 0.275 B 295 266 16 0 0 14 [[20, 270]] 1.0 4nzw Homo sapiens STE_STK25_HUMAN STE 1e-99 339.1 1 257 257 157 158 159 161 163 49 66 70 137 139 138 140 197 185 180 179 178 177 176 175 174 96 Serine/threonine-protein kinase 25
STE STK26 STK26_HUMAN 4FZFB Q9P289 18 297 416.0 DKI:60301 Type1 Inactive DFGinter 9.133 5.046 None DFGAsp-rot-none -57.65, 114.3 -69.67, -9.9 999.0, 999.0 -61.28, -25.81 270.87, 114.11 -63.61, -36.75 out-out out 10.29 Saltbr-out 4.539 HRD-in -96.17, -41.99 66.86, 3.24 out-out-out SNCooo out-out ActLoopNT-out 5.19 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -97.12, 126.65 APE9-dihe-na -67.92, -45.65 APE8-dihe-in -99.44, 130.82 APE8-rot-out 45.3 APE67-dihe-in -58.16, -40.48 -83.63, -4.41 APE12-dist-in 10.491 APE11-dist-in 13.842 APE10-dist-out 12.302 APE9-dist-out 9.632 D162A None None XRAY 3.64 0.255 0.309 B 283 278 2 0 0 0 [[24, 274]] 1.0 4fzf Homo sapiens STE_STK26_HUMAN STE 7e-99 336.3 1 257 257 161 162 163 165 167 53 70 74 141 143 142 144 201 189 184 183 182 181 180 179 178 100 Serine/threonine-protein kinase 26
STE TNIK TNIK_HUMAN 8X88A Q9UKE5 15 311 1360.0 No_ligand No_ligand Inactive DFGinter 5.725 9.945 None DFGAsp-rot-in -92.61, 126.66 78.57, 160.72 201.29, -1.03 -147.84, 30.92 39.89, 92.66 114.91, -1.91 out-out out 13.653 Saltbr-out 13.772 HRD-in -94.03, -60.42 72.05, 9.07 out-out-out SNCooo out-out ActLoopNT-out 5.487 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -151.41 APE9-dihe-na -127.93, -146.37 APE8-dihe-in -61.41, 141.34 APE8-rot-out 49.25 APE67-dihe-in -64.12, -24.22 -101.87, 9.65 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 14.573 APE9-dist-out 10.143 None None None XRAY 2.7 0.201 0.256 A 304 294 3 0 0 3 [[25, 289]] 1.0 8x88 Homo sapiens STE_TNIK_HUMAN STE 3e-105 357.2 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
STE TNIK TNIK_HUMAN 8X88B Q9UKE5 17 311 1360.0 No_ligand No_ligand Inactive DFGinter 5.705 9.985 None DFGAsp-rot-in -90.48, 120.54 88.19, 158.07 203.69, -8.59 -146.13, 29.2 40.03, 97.67 115.62, 0.39 out-out out 14.512 Saltbr-out 13.634 HRD-in -79.11, -58.67 70.41, 12.41 out-out-out SNCooo out-out ActLoopNT-out 5.012 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -66.52, 155.13 APE9-dihe-na -65.68, 177.97 APE8-dihe-out 49.97, 73.81 APE8-rot-out 69.45 APE67-dihe-in -68.36, -20.09 -87.33, 12.07 APE12-dist-out 17.505 APE11-dist-out 17.455 APE10-dist-out 12.947 APE9-dist-out 10.863 None None None XRAY 2.7 0.201 0.256 B 304 291 4 0 0 0 [[25, 289]] 1.0 8x88 Homo sapiens STE_TNIK_HUMAN STE 3e-105 357.2 1 257 257 170 171 172 174 176 54 69 73 150 152 151 153 215 198 193 192 191 190 189 188 187 106 TRAF2 and NCK-interacting protein kinase
TKL ILK ILK_HUMAN 9D5IA Q13418 182 452 452.0 ATP:502 ATPlike Pseudo DFGinter 8.261 6.842 None DFGAsp-rot-na -85.91, 104.5 -70.94, -26.25 293.39, -38.09 -67.8, 1.23 999.0, 999.0 -109.51, 3.6 out-out out 13.611 Saltbr-out 13.777 HRD-out 63.45, 28.98 -91.0, 110.88 out-out-out SNCooo out-out ActLoopNT-out 6.365 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioo APE10-dihe-na -132.95, 115.89 APE9-dihe-na -99.41, -2.16 APE8-dihe-in -138.47, 54.8 APE8-rot-none 999.0 APE67-dihe-in -62.49, -23.03 -64.85, -19.12 APE12-dist-out 14.705 APE11-dist-in 13.99 APE10-dist-out 13.138 APE9-dist-out 13.265 R225A,C346S,C422S None None XRAY 1.5 0.23 0.267 A 271 271 0 0 0 0 [[192, 448]] 1.0 9d5i Homo sapiens TKL_ILK_HUMAN TKL 2.8e-62 216.7 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 3KMWA Q13418 185 452 452.0 ATP:502 ATPlike Pseudo DFGinter 8.3 6.975 None DFGAsp-rot-na -80.97, 99.65 -67.11, -24.75 293.32, -37.12 -72.37, 0.55 999.0, 999.0 -103.25, 4.58 out-out out 13.496 Saltbr-out 14.041 HRD-out 59.64, 26.4 -91.04, 116.86 out-out-out SNCooo out-out ActLoopNT-out 6.367 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -122.08, 118.72 APE9-dihe-na -100.74, -5.98 APE8-dihe-in -137.53, 58.2 APE8-rot-none 999.0 APE67-dihe-in -63.57, -23.06 -67.47, -16.05 APE12-dist-out 14.71 APE11-dist-out 14.04 APE10-dist-out 13.057 APE9-dist-out 13.027 C346S,C422S None None XRAY 2.0 0.199 0.203 A 271 268 0 0 0 0 [[192, 448]] 1.0 3kmw Homo sapiens TKL_ILK_HUMAN TKL 1.6e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 3REPA Q13418 185 452 452.0 ATP:502 ATPlike Pseudo DFGinter 8.264 6.894 None DFGAsp-rot-na -81.35, 101.61 -70.12, -25.38 296.57, -45.73 -69.18, -5.31 999.0, 999.0 -98.03, -0.84 out-out out 13.359 Saltbr-out 14.12 HRD-out 62.24, 23.62 -86.21, 112.03 out-out-out SNCooo out-out ActLoopNT-out 6.454 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioo APE10-dihe-na -114.84, 122.73 APE9-dihe-na -97.69, -5.36 APE8-dihe-in -136.02, 58.25 APE8-rot-none 999.0 APE67-dihe-in -57.73, -27.19 -63.83, -23.69 APE12-dist-out 14.498 APE11-dist-in 13.981 APE10-dist-out 12.94 APE9-dist-out 13.101 C346S,C422S None None XRAY 1.8 0.206 0.238 A 271 268 0 0 0 0 [[192, 448]] 1.0 3rep Homo sapiens TKL_ILK_HUMAN TKL 1.6e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 3KMUA Q13418 185 451 452.0 No_ligand No_ligand Pseudo DFGinter 8.115 7.023 None DFGAsp-rot-none -89.09, 107.07 -68.14, -22.77 999.0, 999.0 -71.11, -14.21 999.0, 999.0 -91.44, 11.74 out-out out 13.695 Saltbr-out 11.012 HRD-out 62.49, 27.89 -91.99, 115.71 out-out-out SNCooo out-out ActLoopNT-out 6.597 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -104.26, 122.36 APE9-dihe-na -103.82, -5.41 APE8-dihe-in -135.57, 56.37 APE8-rot-none 999.0 APE67-dihe-in -59.41, -24.29 -65.19, -22.44 APE12-dist-out 15.046 APE11-dist-out 14.132 APE10-dist-out 12.999 APE9-dist-out 12.97 C346S,C422S None MSE272,MSE301,MSE305,MSE326,MSE331,MSE337,MSE350,MSE375,MSE398,MSE402,MSE425,MSE429,MSE441,MSE449 XRAY 1.8 0.202 0.236 A 271 267 0 0 0 0 [[192, 448]] 1.0 3kmu Homo sapiens TKL_ILK_HUMAN TKL 1.6e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 6MIBA Q13418 183 452 452.0 No_ligand No_ligand Pseudo DFGinter 8.103 6.953 None DFGAsp-rot-na -87.41, 112.59 -75.98, -22.17 293.42, -48.57 -67.79, -12.67 999.0, 999.0 -94.49, 5.69 out-out out 14.011 Saltbr-out 12.861 HRD-out 64.37, 30.77 -90.77, 118.17 out-out-out SNCooo out-out ActLoopNT-out 6.381 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -106.73, 116.01 APE9-dihe-na -99.88, -3.31 APE8-dihe-in -137.02, 59.23 APE8-rot-none 999.0 APE67-dihe-in -59.55, -22.39 -68.5, -19.71 APE12-dist-out 15.073 APE11-dist-out 14.122 APE10-dist-out 13.25 APE9-dist-out 12.849 L207W None None XRAY 1.8 0.163 0.208 A 271 270 0 0 0 0 [[192, 448]] 1.0 6mib Homo sapiens TKL_ILK_HUMAN TKL 6.9e-62 215.4 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 9D5HA Q13418 182 452 452.0 IRE:701 Type1 Pseudo DFGinter 8.164 7.455 None DFGAsp-rot-na -85.0, 107.56 -70.5, -21.19 315.38, -67.96 -67.61, -12.48 999.0, 999.0 -96.85, 13.46 out-out out 14.137 Saltbr-out 13.105 HRD-out 65.35, 60.25 -109.45, 119.86 out-out-out SNCooo out-out ActLoopNT-out 5.911 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -110.76, 118.05 APE9-dihe-na -102.65, -7.28 APE8-dihe-in -135.36, 55.79 APE8-rot-none 999.0 APE67-dihe-in -64.5, -21.08 -63.95, -18.26 APE12-dist-out 14.988 APE11-dist-out 14.039 APE10-dist-out 13.236 APE9-dist-out 12.723 C346S,R371Q,C422S None None XRAY 1.5 0.197 0.224 A 271 271 0 0 0 0 [[192, 448]] 1.0 9d5h Homo sapiens TKL_ILK_HUMAN TKL 1.2e-62 217.9 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 9D5FA Q13418 182 452 452.0 DB8:501 Type1 Pseudo DFGinter 8.366 7.592 None DFGAsp-rot-na -82.6, 123.95 -74.1, -11.79 295.97, -42.89 -66.74, -13.57 999.0, 999.0 -72.54, 5.75 out-out out 14.123 Saltbr-out 15.4 HRD-out -123.23, 159.13 -69.32, -46.01 out-out-out SNCooo out-out ActLoopNT-out 5.554 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -109.48, 117.62 APE9-dihe-na -102.03, -10.5 APE8-dihe-in -134.11, 56.74 APE8-rot-none 999.0 APE67-dihe-in -63.21, -21.45 -62.91, -18.33 APE12-dist-out 15.638 APE11-dist-out 14.874 APE10-dist-out 14.406 APE9-dist-out 8.782 C346S,C422S None None XRAY 1.5 0.191 0.208 A 271 271 0 0 0 0 [[192, 448]] 1.0 9d5f Homo sapiens TKL_ILK_HUMAN TKL 1.6e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 9D5GAAAA Q13418 182 452 452.0 A1A2V:501 Type1 Pseudo DFGinter 8.166 7.277 None DFGAsp-rot-na -88.06, 117.11 -74.33, -18.91 299.16, -47.39 -68.4, -19.72 999.0, 999.0 -87.44, 16.53 out-out out 13.771 Saltbr-out 14.663 HRD-out 59.25, 38.65 -103.86, 109.49 out-out-out SNCooo out-out ActLoopNT-out 6.383 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioo APE10-dihe-na -94.88, 120.39 APE9-dihe-na -102.76, -4.36 APE8-dihe-in -137.63, 56.3 APE8-rot-none 999.0 APE67-dihe-in -62.91, -23.12 -64.06, -19.38 APE12-dist-out 14.786 APE11-dist-in 13.895 APE10-dist-out 13.122 APE9-dist-out 13.0 C346S,C422S None None XRAY 1.55 0.195 0.221 AAAA 271 271 0 0 0 0 [[192, 448]] 1.0 9d5g Homo sapiens TKL_ILK_HUMAN TKL 1.6e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 9D5PA Q13418 182 452 452.0 AQ4:701 Type1 Pseudo DFGinter 8.061 7.428 None DFGAsp-rot-na -85.71, 111.19 -68.8, -21.89 291.58, -26.21 -73.77, -9.11 999.0, 999.0 -96.7, 8.17 out-out out 13.852 Saltbr-out 12.926 HRD-out 65.12, 30.52 -101.22, 117.74 out-out-out SNCooo out-out ActLoopNT-out 6.577 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioo APE10-dihe-na -117.02, 119.23 APE9-dihe-na -104.23, -7.77 APE8-dihe-in -133.36, 56.94 APE8-rot-none 999.0 APE67-dihe-in -63.3, -21.52 -64.96, -18.17 APE12-dist-out 15.043 APE11-dist-in 13.976 APE10-dist-out 12.889 APE9-dist-out 12.754 C346S,C422S None None XRAY 1.5 0.188 0.21 A 271 271 0 0 0 0 [[192, 448]] 1.0 9d5p Homo sapiens TKL_ILK_HUMAN TKL 1.6e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 9D5EA Q13418 182 452 452.0 IRE:701,IRE:702 Type1,Type1 Pseudo DFGinter 8.017 7.524 None DFGAsp-rot-na -89.37, 112.35 -72.14, -19.5 306.68, -66.94 -70.86, -12.91 999.0, 999.0 -92.65, 14.01 out-out out 14.057 Saltbr-out 13.142 HRD-out -82.68, 123.44 -98.83, 148.34 out-out-out SNCooo out-out ActLoopNT-out 6.639 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioo APE10-dihe-na -111.62, 119.46 APE9-dihe-na -104.32, -7.67 APE8-dihe-in -135.99, 56.58 APE8-rot-none 999.0 APE67-dihe-in -63.74, -21.2 -65.26, -17.82 APE12-dist-out 14.857 APE11-dist-in 13.808 APE10-dist-out 12.922 APE9-dist-out 11.885 C346S,C422S None None XRAY 1.5 0.188 0.21 A 271 271 0 0 0 0 [[192, 448]] 1.0 9d5e Homo sapiens TKL_ILK_HUMAN TKL 1.6e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL LRRK2 LRRK2_HUMAN 7LHTA Q5S007 558 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 9.844 8.295 None DFGAsp-rot-out -64.84, 122.35 -98.75, -0.04 75.34, -29.64 -71.37, -28.28 172.84, 65.91 -59.04, -42.88 out-out out 11.156 Saltbr-out 7.841 HRD-in -69.75, -40.92 72.72, -9.61 out-out-out SNCooo out-out ActLoopNT-out 9.784 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -82.21, -17.19 APE9-dihe-na 90.26, 154.46 APE8-dihe-in -57.7, 141.99 APE8-rot-in 318.57 APE67-dihe-in -63.97, -43.36 -55.36, -52.39 APE12-dist-in 9.673 APE11-dist-in 10.145 APE10-dist-out 14.096 APE9-dist-in 4.097 None None None EM 3.5 999.0 999.0 A 2527 1795 3 0 0 3 [[1875, 2134]] 1.0 7lht Homo sapiens TKL_LRRK2_HUMAN TKL 3.9e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LHTB Q5S007 558 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 9.844 8.295 None DFGAsp-rot-out -64.86, 122.35 -98.72, -0.04 75.34, -29.61 -71.37, -28.3 172.84, 65.9 -59.09, -42.88 out-out out 11.156 Saltbr-out 7.841 HRD-in -69.81, -40.92 72.73, -9.55 out-out-out SNCooo out-out ActLoopNT-out 9.783 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -82.22, -17.15 APE9-dihe-na 90.23, 154.47 APE8-dihe-in -57.69, 142.03 APE8-rot-in 318.55 APE67-dihe-in -64.0, -43.36 -55.37, -52.4 APE12-dist-in 9.672 APE11-dist-in 10.145 APE10-dist-out 14.096 APE9-dist-in 4.097 None None None EM 3.5 999.0 999.0 B 2527 1795 3 0 0 3 [[1875, 2134]] 1.0 7lht Homo sapiens TKL_LRRK2_HUMAN TKL 3.9e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LHWA Q5S007 540 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 10.349 8.277 None DFGAsp-rot-out -70.88, 117.76 -93.02, 2.5 58.27, -6.42 -63.92, -24.19 170.47, 59.39 -60.34, -43.84 out-out out 10.98 Saltbr-out 7.258 HRD-in -74.65, -33.87 72.74, -12.12 out-out-out SNCooo out-out ActLoopNT-out 9.631 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -74.42, -8.25 APE9-dihe-na 81.17, 153.49 APE8-dihe-in -58.6, 142.93 APE8-rot-in 304.43 APE67-dihe-in -63.74, -43.48 -51.59, -53.96 APE12-dist-in 10.236 APE11-dist-in 9.457 APE10-dist-out 13.872 APE9-dist-in 4.335 None None None EM 3.7 999.0 999.0 A 2527 1813 3 0 0 3 [[1875, 2134]] 1.0 7lhw Homo sapiens TKL_LRRK2_HUMAN TKL 3.9e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LI4A Q5S007 558 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 9.844 8.294 None DFGAsp-rot-out -64.77, 122.33 -98.76, -0.03 75.32, -29.62 -71.41, -28.21 172.83, 65.95 -59.02, -42.88 out-out out 11.157 Saltbr-out 7.842 HRD-in -69.78, -40.92 72.72, -9.67 out-out-out SNCooo out-out ActLoopNT-out 9.784 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -82.19, -17.19 APE9-dihe-na 90.26, 154.48 APE8-dihe-in -57.73, 142.01 APE8-rot-in 318.58 APE67-dihe-in -63.98, -43.36 -55.36, -52.38 APE12-dist-in 9.673 APE11-dist-in 10.145 APE10-dist-out 14.096 APE9-dist-in 4.096 None None None EM 3.1 999.0 999.0 A 2527 1795 3 0 0 3 [[1875, 2134]] 1.0 7li4 Homo sapiens TKL_LRRK2_HUMAN TKL 3.9e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO2E Q5S007 12 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 10.549 8.183 None DFGAsp-rot-out -77.97, 115.31 -99.8, 16.1 64.98, -23.23 -71.24, -24.34 179.0, 61.54 -64.41, -41.78 out-out out 11.347 Saltbr-out 7.851 HRD-in -73.2, -35.27 72.81, -10.29 out-out-out SNCooo out-out ActLoopNT-out 9.492 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -67.29, -18.03 APE9-dihe-na 75.0, 160.57 APE8-dihe-in -64.56, 133.01 APE8-rot-in 300.63 APE67-dihe-in -63.84, -35.14 -59.88, -35.03 APE12-dist-in 9.119 APE11-dist-in 10.588 APE10-dist-out 14.447 APE9-dist-in 4.382 None None None EM 4.13 999.0 999.0 E 2527 2275 4 0 0 3 [[1875, 2134]] 1.0 8fo2 Homo sapiens TKL_LRRK2_HUMAN TKL 3.9e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO8C Q5S007 12 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 10.404 8.367 None DFGAsp-rot-out -77.76, 115.2 -99.79, 16.57 65.05, -23.2 -70.68, -24.12 178.89, 61.58 -64.22, -41.72 out-out out 11.341 Saltbr-out 7.744 HRD-in -73.07, -35.29 72.76, -10.32 out-out-out SNCooo out-out ActLoopNT-out 9.471 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -67.5, -18.26 APE9-dihe-na 74.89, 160.43 APE8-dihe-in -64.77, 133.4 APE8-rot-in 300.66 APE67-dihe-in -63.6, -35.05 -59.67, -34.64 APE12-dist-in 9.071 APE11-dist-in 10.522 APE10-dist-out 14.411 APE9-dist-in 4.449 None None None EM 3.88 999.0 999.0 C 2527 2270 4 0 0 3 [[1875, 2134]] 1.0 8fo8 Homo sapiens TKL_LRRK2_HUMAN TKL 3.9e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO8E Q5S007 12 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 10.415 8.349 None DFGAsp-rot-out -77.68, 115.13 -99.83, 16.55 65.04, -23.26 -70.64, -24.07 178.91, 61.52 -64.18, -41.73 out-out out 11.321 Saltbr-out 7.73 HRD-in -73.0, -35.27 72.87, -10.42 out-out-out SNCooo out-out ActLoopNT-out 9.47 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -67.4, -18.35 APE9-dihe-na 74.93, 160.44 APE8-dihe-in -64.61, 133.34 APE8-rot-in 300.72 APE67-dihe-in -63.56, -35.05 -59.56, -34.8 APE12-dist-in 9.056 APE11-dist-in 10.526 APE10-dist-out 14.406 APE9-dist-in 4.434 None None None EM 3.88 999.0 999.0 E 2527 2270 4 0 0 3 [[1875, 2134]] 1.0 8fo8 Homo sapiens TKL_LRRK2_HUMAN TKL 3.9e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO9F Q5S007 12 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 9.348 8.575 None DFGAsp-rot-out -68.36, 152.72 -137.53, 18.95 46.03, -4.12 -81.54, -22.77 187.88, 51.61 -70.19, -36.74 out-out out 11.238 Saltbr-out 8.326 HRD-in -76.93, -42.26 72.06, -11.17 out-out-out SNCooo out-out ActLoopNT-out 9.106 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -70.82, -18.07 APE9-dihe-na 87.94, 175.98 APE8-dihe-in -63.48, 135.16 APE8-rot-in 300.23 APE67-dihe-in -66.37, -45.6 -58.88, -37.04 APE12-dist-in 9.718 APE11-dist-in 10.578 APE10-dist-out 14.122 APE9-dist-in 4.473 None None None EM 3.48 999.0 999.0 F 2527 2289 3 0 0 3 [[1875, 2134]] 1.0 8fo9 Homo sapiens TKL_LRRK2_HUMAN TKL 3.9e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8VH5A Q5S007 12 2527 2527.0 ANP:2602 ATPlike Inactive DFGinter 9.746 8.455 None DFGAsp-rot-out -88.01, 106.84 -81.35, 17.64 52.43, -6.32 -78.83, -10.5 197.42, 64.93 -68.71, -22.79 out-out out 11.326 Saltbr-out 8.123 HRD-in -105.05, -49.61 72.56, -5.72 out-out-out SNCooo out-out ActLoopNT-out 8.961 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -67.06, -23.38 APE9-dihe-na 73.72, 168.0 APE8-dihe-in -68.8, 143.98 APE8-rot-out 58.99 APE67-dihe-in -65.74, -54.3 -73.05, -29.17 APE12-dist-in 9.633 APE11-dist-in 8.416 APE10-dist-out 13.344 APE9-dist-in 3.861 None None None EM 4.0 999.0 999.0 A 2527 2221 8 0 0 8 [[1875, 2134]] 1.0 8vh5 Homo sapiens TKL_LRRK2_HUMAN TKL 3.9e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8VH5C Q5S007 12 2527 2527.0 ANP:2602 ATPlike Inactive DFGinter 9.746 8.455 None DFGAsp-rot-out -88.01, 106.86 -81.36, 17.7 52.44, -6.38 -78.84, -10.6 197.4, 64.92 -68.66, -22.76 out-out out 11.325 Saltbr-out 8.122 HRD-in -104.99, -49.63 72.52, -5.67 out-out-out SNCooo out-out ActLoopNT-out 8.961 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioi APE10-dihe-na -66.98, -23.42 APE9-dihe-na 73.64, 168.02 APE8-dihe-in -68.73, 143.93 APE8-rot-out 59.0 APE67-dihe-in -65.76, -54.24 -73.07, -29.13 APE12-dist-in 9.633 APE11-dist-in 8.418 APE10-dist-out 13.345 APE9-dist-in 3.862 None None None EM 4.0 999.0 999.0 C 2527 2221 8 0 0 8 [[1875, 2134]] 1.0 8vh5 Homo sapiens TKL_LRRK2_HUMAN TKL 3.9e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LI3A Q5S007 558 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 9.583 8.403 None DFGAsp-rot-out -64.7, 121.5 -105.97, 8.82 66.89, -22.77 -69.04, -26.41 175.66, 65.26 -63.25, -46.61 out-out out 11.401 Saltbr-out 8.121 HRD-in -76.04, -34.97 73.14, -12.04 out-out-out SNCooo out-out ActLoopNT-out 9.664 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -85.32, -9.76 APE9-dihe-na 87.27, 160.92 APE8-dihe-in -56.79, 143.13 APE8-rot-in 300.33 APE67-dihe-in -63.35, -39.62 -56.92, -55.07 APE12-dist-in 10.386 APE11-dist-in 10.363 APE10-dist-out 14.006 APE9-dist-in 3.652 None None None EM 3.8 999.0 999.0 A 2527 1795 3 0 0 3 [[1875, 2134]] 1.0 7li3 Homo sapiens TKL_LRRK2_HUMAN TKL 4e-56 197.0 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 9CI3A Q5S007 907 2527 2527.0 No_ligand No_ligand Inactive DFGinter 10.474 8.279 None DFGAsp-rot-out -66.48, 130.02 -90.44, 1.88 58.64, -2.06 -71.41, -23.46 187.57, 71.09 -65.75, -44.61 out-out out 11.224 Saltbr-out 6.863 HRD-in -66.49, -44.27 66.72, -4.67 out-out-out SNCooo out-out ActLoopNT-out 9.42 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -69.6, -18.48 APE9-dihe-na 81.06, 161.8 APE8-dihe-in -67.87, 131.88 APE8-rot-in 311.06 APE67-dihe-in -65.99, -44.62 -57.57, -36.48 APE12-dist-in 9.74 APE11-dist-in 9.32 APE10-dist-out 13.78 APE9-dist-in 4.548 None SEP910,SEP935 SEP910,SEP935 EM 3.96 999.0 999.0 A 2562 1521 3 0 0 3 [[1875, 2134]] 1.0 9ci3 Homo sapiens TKL_LRRK2_HUMAN TKL 4e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL MAP3K7 M3K7_HUMAN 8GW3B O43318 27 497 606.0 No_ligand No_ligand Inactive DFGinter 7.307 10.874 None DFGAsp-rot-in -117.09, 7.66 -155.39, 153.46 202.23, -8.2 -120.54, 145.11 298.27, 66.91 -71.46, 166.75 out-out out 13.58 Saltbr-out 9.583 HRD-in -69.79, -54.63 87.1, -10.39 out-out-out SNCooo out-out ActLoopNT-out 9.872 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -79.79, -8.62 APE9-dihe-na 73.87, 28.3 APE8-dihe-out -98.45, 5.64 APE8-rot-in 294.07 APE67-dihe-in -64.55, -14.4 -62.64, -34.37 APE12-dist-in 11.412 APE11-dist-out 15.726 APE10-dist-out 10.031 APE9-dist-out 10.969 None None None XRAY 2.05 0.223 0.258 B 326 277 0 0 0 0 [[36, 286]] 1.0 8gw3 Homo sapiens TKL_MAP3K7_HUMAN TKL 4.7e-74 255.3 2 266 265 174 175 176 178 180 63 77 81 153 155 154 156 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
TKL MAP3K7 M3K7_HUMAN 8GW3C O43318 25 497 606.0 No_ligand No_ligand Inactive DFGinter 7.0 10.838 None DFGAsp-rot-in -118.88, 9.98 -158.01, 154.4 204.98, -32.63 -119.85, 146.31 299.32, 82.07 -75.37, 164.49 out-none out 13.13 Saltbr-none 999.0 HRD-in -72.49, -54.99 85.65, -8.16 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iooo APE10-dihe-na -79.4, -8.44 APE9-dihe-na 70.7, 25.06 APE8-dihe-out -96.14, 11.17 APE8-rot-in 290.65 APE67-dihe-in -65.82, -14.66 -63.16, -38.68 APE12-dist-in 9.575 APE11-dist-out 14.505 APE10-dist-out 9.463 APE9-dist-out 10.679 None None None XRAY 2.05 0.223 0.258 C 326 276 3 0 0 3 [[36, 286]] 1.0 8gw3 Homo sapiens TKL_MAP3K7_HUMAN TKL 4.7e-74 255.3 2 266 265 174 175 176 178 180 63 77 81 153 155 154 156 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
TKL MAP3K7 M3K7_HUMAN 8GW3D O43318 27 495 606.0 No_ligand No_ligand Inactive DFGinter 7.447 10.844 None DFGAsp-rot-in -119.27, 7.31 -156.44, 153.6 205.24, 1.95 -121.29, 145.39 298.84, 83.74 -68.76, 164.64 out-out out 12.825 Saltbr-out 10.037 HRD-in -70.85, -56.03 85.08, -6.45 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_iioo APE10-dihe-na 89.94, -46.56 APE9-dihe-na 70.84, 30.69 APE8-dihe-out -97.92, 9.04 APE8-rot-in 302.34 APE67-dihe-in -65.06, -14.35 -59.83, -33.2 APE12-dist-in 12.435 APE11-dist-in 12.713 APE10-dist-out 9.855 APE9-dist-out 10.569 None None None XRAY 2.05 0.223 0.258 D 326 274 3 0 0 3 [[36, 286]] 1.0 8gw3 Homo sapiens TKL_MAP3K7_HUMAN TKL 4.7e-74 255.3 2 266 265 174 175 176 178 180 63 77 81 153 155 154 156 211 199 194 193 192 191 190 189 188 105 Mitogen-activated protein kinase kinase kinase 7
TYR ABL1 ABL1_HUMAN 7W7XA P00519 232 500 1130.0 8DW:601 Type1 Inactive DFGinter 9.558 7.786 BABtrans DFGAsp-rot-out -66.93, 131.45 -122.59, 21.38 47.1, 10.78 -82.27, 129.13 176.71, 100.61 108.56, 2.12 in-out in 8.665 Saltbr-out 7.93 HRD-in -95.77, -52.9 76.52, -0.83 out-out-in SNCooi out-in ActLoopNT-out 5.685 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -108.59, 134.23 APE9-dihe-in -113.71, 159.94 APE8-dihe-in -76.77, 96.08 APE8-rot-na 26.73 APE67-dihe-in -68.1, -14.3 -52.64, -46.2 APE12-dist-na 19.828 APE11-dist-na 15.129 APE10-dist-na 17.953 APE9-dist-na 7.347 None PTR393 PTR393 XRAY 2.0 0.169 0.195 A 272 267 2 0 0 0 [[242, 495]] 1.0 7w7x Homo sapiens TYR_ABL1_HUMAN TYR 2.3e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7W7XB P00519 232 500 1130.0 8DW:601 Type1 Inactive DFGinter 9.845 8.188 BABtrans DFGAsp-rot-out -65.38, 135.53 -123.74, 24.69 47.69, 9.78 -80.57, 130.18 174.46, 98.91 106.66, 2.32 in-out in 9.036 Saltbr-out 8.33 HRD-in -94.74, -54.5 74.93, -0.49 out-out-in SNCooi out-in ActLoopNT-out 5.562 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -108.89, 134.45 APE9-dihe-in -117.49, 159.07 APE8-dihe-in -74.94, 99.68 APE8-rot-na 25.49 APE67-dihe-in -68.63, -15.91 -51.43, -45.15 APE12-dist-na 18.715 APE11-dist-na 13.996 APE10-dist-na 17.134 APE9-dist-na 6.992 None PTR393 PTR393 XRAY 2.0 0.169 0.195 B 272 264 5 0 0 0 [[242, 495]] 1.0 7w7x Homo sapiens TYR_ABL1_HUMAN TYR 2.3e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 4XEYB P00519 122 504 1130.0 1N1:60601 Type1 Inactive DFGinter 10.001 8.022 BABtrans DFGAsp-rot-out -71.04, 121.63 -84.68, 7.52 349.51, 69.76 -91.76, 101.26 207.86, 90.35 143.13, -1.76 in-out in 8.918 Saltbr-out 8.643 HRD-out -101.25, 126.15 -79.9, -27.01 out-out-in SNCooi out-in ActLoopNT-out 5.422 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -80.63, 133.07 APE9-dihe-in -116.3, 152.74 APE8-dihe-in -66.44, 99.47 APE8-rot-na 21.89 APE67-dihe-in -71.31, -17.26 -44.98, -48.3 APE12-dist-na 18.56 APE11-dist-na 13.923 APE10-dist-na 16.549 APE9-dist-na 6.428 None None None XRAY 2.891 0.232 0.259 B 408 359 9 0 0 0 [[242, 495]] 1.0 4xey Homo sapiens TYR_ABL1_HUMAN TYR 8.7e-100 339.5 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7N9GA P00519 233 498 1130.0 STI:60601,1N1:60602 Allosteric,Type1 Inactive DFGinter 10.421 8.187 None DFGAsp-rot-out -69.43, 136.44 -123.08, 27.78 36.77, 17.81 -75.4, -30.96 178.85, 77.99 -98.31, 50.2 in-out in 8.878 Saltbr-out 9.786 HRD-out -92.88, 142.81 -110.01, 0.88 out-out-none SNCoon out-none ActLoopNT-out 5.544 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 170.84 APE8-dihe-in -72.01, 95.09 APE8-rot-na 30.25 APE67-dihe-in -73.75, -10.66 -54.08, -44.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 5.85 None None None XRAY 2.2 0.219 0.251 A 271 250 16 0 0 13 [[242, 495]] 1.0 7n9g Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7N9GC P00519 234 499 1130.0 STI:60601,1N1:60602 Allosteric,Type1 Inactive DFGinter 10.016 7.762 None DFGAsp-rot-out -68.53, 140.81 -120.26, 3.31 42.8, 4.62 -57.57, -42.4 182.82, 108.58 -86.96, 40.71 in-none in 9.439 Saltbr-none 999.0 HRD-out -106.92, 134.12 -80.26, -30.58 none-out-none SNCnon out-none ActLoopNT-out 5.478 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 96.82 APE8-dihe-in -65.53, 99.76 APE8-rot-na 23.57 APE67-dihe-in -73.61, -20.46 -60.17, -42.86 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.891 None None None XRAY 2.2 0.219 0.251 C 271 233 33 0 0 5 [[242, 495]] 1.0 7n9g Homo sapiens TYR_ABL1_HUMAN TYR 2.2e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2G2FA P00519 232 506 1130.0 No_ligand No_ligand Inactive DFGinter 9.904 7.215 None DFGAsp-rot-out -62.11, 127.98 -87.38, -14.52 62.79, -38.92 -64.34, -9.9 184.11, 68.76 -103.31, 15.09 in-out in 8.923 Saltbr-out 8.97 HRD-out -103.65, 121.34 -60.45, -26.89 out-out-in SNCooi out-in ActLoopNT-out 5.537 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -96.48, 145.14 APE9-dihe-in -132.2, 154.35 APE8-dihe-in -76.87, 87.18 APE8-rot-na 28.49 APE67-dihe-in -66.0, -4.27 -34.28, -57.53 APE12-dist-na 21.406 APE11-dist-na 16.576 APE10-dist-na 17.867 APE9-dist-na 7.431 H396P None None XRAY 2.7 0.234 0.286 A 287 275 0 0 0 0 [[242, 495]] 1.0 2g2f Homo sapiens TYR_ABL1_HUMAN TYR 7.1e-100 339.6 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 6BL8A P00519 233 502 1130.0 PVB:601 Type1 Inactive DFGinter 8.638 5.129 None DFGAsp-rot-out -71.96, 143.85 -136.17, 39.9 55.89, -9.14 -72.13, -37.4 288.6, 104.47 -92.65, 14.81 in-out in 8.634 Saltbr-out 7.155 HRD-in -90.04, -55.84 74.1, 2.35 out-out-in SNCooi out-in ActLoopNT-out 5.726 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -101.55, 128.85 APE9-dihe-in -120.75, 157.5 APE8-dihe-in -76.2, 98.23 APE8-rot-na 22.7 APE67-dihe-in -70.51, -5.85 -42.21, -49.52 APE12-dist-na 19.841 APE11-dist-na 15.131 APE10-dist-na 17.437 APE9-dist-na 7.088 None None None XRAY 2.5 0.177 0.204 A 272 270 0 0 0 0 [[242, 495]] 1.0 6bl8 Homo sapiens TYR_ABL1_HUMAN TYR 1e-99 339.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 6BL8B P00519 233 504 1130.0 PVB:601 Type1 Inactive DFGinter 8.616 5.229 None DFGAsp-rot-out -71.73, 142.55 -134.64, 39.69 56.88, -9.98 -72.51, -38.46 288.36, 104.6 -92.85, 14.3 in-none in 8.487 Saltbr-none 999.0 HRD-in -91.59, -53.55 75.4, -2.02 none-out-in SNCnoi out-in ActLoopNT-out 5.421 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -102.94, 127.06 APE9-dihe-in -119.46, 155.16 APE8-dihe-in -72.29, 100.21 APE8-rot-na 22.45 APE67-dihe-in -69.04, -6.83 -41.1, -50.73 APE12-dist-na 19.223 APE11-dist-na 14.504 APE10-dist-na 17.351 APE9-dist-na 6.845 None None None XRAY 2.5 0.177 0.204 B 272 268 4 0 0 1 [[242, 495]] 1.0 6bl8 Homo sapiens TYR_ABL1_HUMAN TYR 1e-99 339.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 8I7SA P00519 232 500 1130.0 6CI:601 Type1 Inactive DFGinter 9.134 7.631 None DFGAsp-rot-out -67.26, 134.08 -124.25, 38.37 45.66, 13.05 -90.11, -15.51 320.43, 108.35 -104.88, 9.69 in-in in 8.711 Saltbr-in 2.997 HRD-in -101.62, -50.5 73.92, -2.89 in-out-in SNCioi out-in ActLoopNT-out 5.643 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -105.21, 132.08 APE9-dihe-in -105.71, 156.86 APE8-dihe-in -74.32, 88.38 APE8-rot-na 26.42 APE67-dihe-in -74.59, -6.02 -50.76, -44.43 APE12-dist-na 19.815 APE11-dist-na 15.13 APE10-dist-na 17.859 APE9-dist-na 7.511 None PTR393 PTR393 XRAY 1.946 0.186 0.216 A 272 262 7 0 0 0 [[242, 495]] 1.0 8i7s Homo sapiens TYR_ABL1_HUMAN TYR 2.3e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 8I7SB P00519 232 500 1130.0 6CI:601 Type1 Inactive DFGinter 8.73 7.672 None DFGAsp-rot-out -65.46, 135.7 -123.29, 38.43 48.98, -16.46 -94.21, -15.86 318.08, 102.31 -104.7, 7.72 in-out in 8.739 Saltbr-out 4.579 HRD-in -100.98, -46.35 75.57, -9.9 out-out-in SNCooi out-in ActLoopNT-out 5.393 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -103.26, 135.01 APE9-dihe-in -100.5, 152.85 APE8-dihe-in -79.3, 86.45 APE8-rot-na 26.11 APE67-dihe-in -72.94, -9.36 -50.77, -43.49 APE12-dist-na 18.49 APE11-dist-na 13.88 APE10-dist-na 16.57 APE9-dist-na 7.198 None PTR393 PTR393 XRAY 1.946 0.186 0.216 B 272 264 5 0 0 0 [[242, 495]] 1.0 8i7s Homo sapiens TYR_ABL1_HUMAN TYR 2.3e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 8I7ZB P00519 232 500 1130.0 6CI:601 Type1 Inactive DFGinter 8.467 7.129 None DFGAsp-rot-out -66.85, 127.11 -111.9, 44.88 48.0, 3.6 -97.85, -10.98 300.72, 89.67 -118.62, 22.53 in-in in 8.811 Saltbr-in 3.079 HRD-in -103.27, -34.43 69.06, -16.77 in-out-in SNCioi out-in ActLoopNT-out 5.476 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -96.59, 128.54 APE9-dihe-in -113.43, 144.92 APE8-dihe-in -66.08, 92.18 APE8-rot-na 22.51 APE67-dihe-in -69.32, -14.4 -51.28, -44.78 APE12-dist-na 18.584 APE11-dist-na 13.952 APE10-dist-na 16.689 APE9-dist-na 6.907 None PTR393 PTR393 XRAY 2.255 0.177 0.213 B 272 265 4 0 0 0 [[242, 495]] 1.0 8i7z Homo sapiens TYR_ABL1_HUMAN TYR 2.3e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7W7YA P00519 232 500 1130.0 8IW:601 Type1 Inactive DFGinter 8.383 7.452 None DFGAsp-rot-in -61.0, 140.15 -123.07, 7.15 215.31, -5.83 -97.99, -19.69 299.86, 99.82 -107.54, 26.38 in-out in 7.832 Saltbr-out 4.324 HRD-in -95.67, -53.61 79.5, -5.33 out-out-in SNCooi out-in ActLoopNT-out 5.716 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -110.53, 135.86 APE9-dihe-in -112.22, 154.02 APE8-dihe-in -72.0, 92.74 APE8-rot-na 26.94 APE67-dihe-in -71.4, -8.88 -51.03, -45.88 APE12-dist-na 19.642 APE11-dist-na 14.989 APE10-dist-na 18.032 APE9-dist-na 7.453 None PTR393 PTR393 XRAY 2.2 0.176 0.201 A 276 269 0 0 0 0 [[242, 495]] 1.0 7w7y Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7W7YB P00519 232 500 1130.0 8IW:601 Type1 Inactive DFGinter 8.706 7.939 None DFGAsp-rot-out -67.02, 132.31 -125.55, 45.99 47.08, 1.9 -104.04, 122.68 325.21, 94.33 94.56, 12.27 in-out in 9.12 Saltbr-out 4.526 HRD-in -107.75, -54.39 71.9, 2.12 out-out-in SNCooi out-in ActLoopNT-out 5.463 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -111.81, 139.55 APE9-dihe-in -122.0, 156.17 APE8-dihe-in -66.34, 94.72 APE8-rot-na 24.45 APE67-dihe-in -67.89, -13.14 -48.19, -46.95 APE12-dist-na 18.655 APE11-dist-na 14.121 APE10-dist-na 17.512 APE9-dist-na 7.157 None PTR393 PTR393 XRAY 2.2 0.176 0.201 B 276 267 2 0 0 0 [[242, 495]] 1.0 7w7y Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 8H7FA P00519 232 500 1130.0 QEW:601 Type1 Inactive DFGinter 8.439 7.331 None DFGAsp-rot-out -69.17, 127.91 -123.7, 53.27 50.62, -18.28 -97.59, -18.49 298.04, 92.12 -115.41, 32.43 in-none in 7.913 Saltbr-none 999.0 HRD-in -98.47, -51.88 73.34, 1.6 none-out-in SNCnoi out-in ActLoopNT-out 5.774 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -98.81, 130.64 APE9-dihe-in -111.12, 149.71 APE8-dihe-in -68.85, 91.65 APE8-rot-na 24.28 APE67-dihe-in -80.23, -2.27 -54.19, -39.54 APE12-dist-na 19.803 APE11-dist-na 15.167 APE10-dist-na 17.763 APE9-dist-na 7.415 None PTR393 PTR393 XRAY 2.45 0.206 0.234 A 277 267 2 0 0 0 [[242, 495]] 1.0 8h7f Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 8H7FB P00519 233 500 1130.0 QEW:601 Type1 Inactive DFGinter 8.625 7.629 None DFGAsp-rot-out -66.82, 132.57 -128.02, 53.13 50.48, -22.83 -102.99, -16.57 308.49, 91.71 -113.57, 28.76 in-none in 8.398 Saltbr-none 999.0 HRD-out -118.2, 104.8 -89.8, 17.52 none-out-in SNCnoi out-in ActLoopNT-out 5.639 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -85.35, 131.94 APE9-dihe-in -101.32, 145.24 APE8-dihe-in -82.14, 94.32 APE8-rot-na 25.72 APE67-dihe-in -72.86, -15.28 -51.55, -45.38 APE12-dist-na 18.504 APE11-dist-na 13.782 APE10-dist-na 16.382 APE9-dist-na 7.368 None PTR393 PTR393 XRAY 2.45 0.206 0.234 B 277 257 11 0 0 0 [[242, 495]] 1.0 8h7f Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 8H7HA P00519 232 500 1130.0 QH9:601 Type1 Inactive DFGinter 8.39 7.687 None DFGAsp-rot-out -66.88, 126.67 -122.6, 45.68 45.63, 9.98 -99.68, -4.7 302.75, 91.96 -123.88, 23.24 in-none in 8.036 Saltbr-none 999.0 HRD-in -99.74, -50.53 75.81, -4.43 none-out-in SNCnoi out-in ActLoopNT-out 5.704 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -107.51, 132.84 APE9-dihe-in -111.46, 154.74 APE8-dihe-in -71.0, 89.59 APE8-rot-na 25.0 APE67-dihe-in -73.93, -5.32 -52.54, -45.5 APE12-dist-na 19.749 APE11-dist-na 15.182 APE10-dist-na 18.067 APE9-dist-na 7.438 None PTR393 PTR393 XRAY 2.278 0.185 0.221 A 277 269 0 0 0 0 [[242, 495]] 1.0 8h7h Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 8H7HB P00519 232 500 1130.0 QH9:601 Type1 Inactive DFGinter 8.489 7.865 None DFGAsp-rot-out -64.21, 134.18 -129.36, 51.05 47.05, 4.6 -106.57, -14.6 307.18, 95.7 -114.91, 23.11 in-none in 8.74 Saltbr-none 999.0 HRD-in -105.06, -54.2 71.08, 0.92 none-out-in SNCnoi out-in ActLoopNT-out 5.593 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -94.95, 127.69 APE9-dihe-in -114.73, 145.44 APE8-dihe-in -67.21, 95.26 APE8-rot-na 23.35 APE67-dihe-in -67.71, -18.52 -54.95, -42.72 APE12-dist-na 18.697 APE11-dist-na 13.937 APE10-dist-na 16.449 APE9-dist-na 6.698 None PTR393 PTR393 XRAY 2.278 0.185 0.221 B 277 258 11 0 0 0 [[242, 495]] 1.0 8h7h Homo sapiens TYR_ABL1_HUMAN TYR 2.4e-100 341.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 4ZOGA P00519 233 501 1130.0 VX6:601 Type1 Inactive DFGinter 9.034 8.188 None DFGAsp-rot-out -67.97, 132.1 -127.82, 25.62 52.96, 14.23 -66.74, -66.47 163.98, 49.73 -79.37, 45.35 out-out out 10.975 Saltbr-out 6.767 HRD-out -91.32, 151.74 -125.52, 16.46 out-out-in SNCooi out-in ActLoopNT-out 5.502 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -110.42, 138.31 APE9-dihe-in -118.45, 160.42 APE8-dihe-in -78.39, 96.94 APE8-rot-na 30.14 APE67-dihe-in -71.46, -10.56 -52.82, -45.85 APE12-dist-na 19.808 APE11-dist-na 15.163 APE10-dist-na 17.423 APE9-dist-na 7.144 None None None XRAY 2.3 0.187 0.233 A 283 269 0 0 0 0 [[242, 495]] 1.0 4zog Homo sapiens TYR_ABL1_HUMAN TYR 2.6e-100 341.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7CC2A P00519 233 501 1130.0 FVC:601 Type1 Inactive DFGinter 9.165 8.258 None DFGAsp-rot-out -73.32, 112.44 -109.3, 64.01 49.52, -6.13 -105.28, -20.44 309.47, 116.75 -109.01, 28.74 out-out out 11.085 Saltbr-out 8.369 HRD-in -90.34, -46.17 72.58, 0.36 out-out-in SNCooi out-in ActLoopNT-out 5.617 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -99.21, 129.2 APE9-dihe-in -111.79, 156.63 APE8-dihe-in -66.39, 106.43 APE8-rot-na 344.92 APE67-dihe-in -73.87, -6.7 -58.13, -47.58 APE12-dist-na 19.252 APE11-dist-na 14.472 APE10-dist-na 17.321 APE9-dist-na 6.862 None None None XRAY 2.723 0.196 0.242 A 310 263 6 0 0 0 [[242, 495]] 1.0 7cc2 Homo sapiens TYR_ABL1_HUMAN TYR 3.7e-100 340.5 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7CC2B P00519 232 501 1130.0 FVC:601 Type1 Inactive DFGinter 8.979 8.607 None DFGAsp-rot-out -71.77, 114.13 -110.49, 61.26 50.29, -7.49 -109.45, -24.12 312.83, 116.95 -111.64, 29.87 in-none in 9.541 Saltbr-none 999.0 HRD-in -88.51, -47.46 71.59, 1.41 none-out-in SNCnoi out-in ActLoopNT-out 5.646 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -97.35, 131.77 APE9-dihe-in -108.11, 154.53 APE8-dihe-in -67.24, 106.75 APE8-rot-na 21.35 APE67-dihe-in -74.13, -7.58 -57.65, -47.12 APE12-dist-na 19.108 APE11-dist-na 14.389 APE10-dist-na 17.586 APE9-dist-na 7.008 None None None XRAY 2.723 0.196 0.242 B 310 266 4 0 0 0 [[242, 495]] 1.0 7cc2 Homo sapiens TYR_ABL1_HUMAN TYR 3.7e-100 340.5 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7DT2A P00519 233 500 1130.0 HJ9:601 Type1 Inactive DFGinter 8.472 7.396 None DFGAsp-rot-out -67.36, 135.71 -126.94, 46.3 45.62, 0.03 -101.94, -14.95 304.55, 98.79 -112.2, 27.67 in-out in 9.0 Saltbr-out 3.798 HRD-in -98.03, -51.7 81.6, -7.87 out-out-in SNCooi out-in ActLoopNT-out 5.749 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -112.44, 133.63 APE9-dihe-in -118.19, 150.76 APE8-dihe-in -62.24, 99.73 APE8-rot-na 22.52 APE67-dihe-in -73.29, -7.91 -58.82, -45.37 APE12-dist-na 19.606 APE11-dist-na 14.956 APE10-dist-na 17.818 APE9-dist-na 7.259 None None None XRAY 2.3 0.208 0.237 A 310 265 3 0 0 0 [[242, 495]] 1.0 7dt2 Homo sapiens TYR_ABL1_HUMAN TYR 3.7e-100 340.5 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 7DT2B P00519 233 500 1130.0 HJ9:601 Type1 Inactive DFGinter 8.633 7.853 None DFGAsp-rot-out -67.09, 137.47 -125.9, 46.84 45.09, -0.88 -103.12, -16.04 307.9, 99.91 -112.15, 26.28 in-out in 9.594 Saltbr-out 4.084 HRD-in -96.99, -47.74 84.36, -13.26 out-out-in SNCooi out-in ActLoopNT-out 5.563 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -113.22, 136.31 APE9-dihe-in -118.25, 150.94 APE8-dihe-in -59.92, 103.33 APE8-rot-na 21.91 APE67-dihe-in -72.55, -10.92 -57.38, -43.07 APE12-dist-na 18.628 APE11-dist-na 13.965 APE10-dist-na 17.355 APE9-dist-na 6.665 None None None XRAY 2.3 0.208 0.237 B 310 267 1 0 0 0 [[242, 495]] 1.0 7dt2 Homo sapiens TYR_ABL1_HUMAN TYR 3.7e-100 340.5 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 2G2HA P00519 233 504 1130.0 P16:60532 Type1 Inactive DFGinter 10.338 7.763 None DFGAsp-rot-out -69.8, 139.79 -117.08, 21.66 33.33, 36.73 -74.78, -30.76 182.98, 70.09 -83.63, 27.99 in-out in 8.947 Saltbr-out 8.475 HRD-out -106.09, 125.25 -68.95, -15.96 out-out-in SNCooi out-in ActLoopNT-out 5.622 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -111.55, 116.51 APE9-dihe-in -118.82, 162.2 APE8-dihe-in -67.24, 92.86 APE8-rot-na 32.82 APE67-dihe-in -70.58, -6.79 -39.4, -50.98 APE12-dist-na 19.946 APE11-dist-na 15.235 APE10-dist-na 17.204 APE9-dist-na 6.534 H396P None None XRAY 2.0 0.194 0.213 A 287 272 0 0 0 0 [[242, 495]] 1.0 2g2h Homo sapiens TYR_ABL1_HUMAN TYR 7.1e-100 339.6 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 4XEYA P00519 231 503 1130.0 1N1:60601 Type1 Inactive DFGinter 9.993 7.927 None DFGAsp-rot-out -70.89, 123.51 -90.91, 18.27 354.04, 64.18 -87.3, -11.95 199.48, 77.0 -96.54, 13.69 in-out in 8.948 Saltbr-out 8.69 HRD-out -101.8, 125.8 -78.66, -28.68 out-out-in SNCooi out-in ActLoopNT-out 5.393 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -77.59, 140.17 APE9-dihe-in -145.27, 142.92 APE8-dihe-in -62.13, 98.18 APE8-rot-na 23.13 APE67-dihe-in -73.29, -19.48 -49.65, -41.78 APE12-dist-na 18.73 APE11-dist-na 14.108 APE10-dist-na 16.542 APE9-dist-na 6.588 None None None XRAY 2.891 0.232 0.259 A 408 269 4 0 0 0 [[242, 495]] 1.0 4xey Homo sapiens TYR_ABL1_HUMAN TYR 8.7e-100 339.5 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 8I7ZA P00519 232 499 1130.0 6CI:601,BAL:602 Type1,Type1 Inactive DFGinter 8.675 7.469 None DFGAsp-rot-out -68.15, 124.34 -115.26, 44.89 50.38, 8.65 -92.28, -20.89 299.64, 92.88 -113.55, 33.09 in-none in 9.013 Saltbr-none 999.0 HRD-in -101.45, -51.38 75.46, -1.93 none-out-in SNCnoi out-in ActLoopNT-out 5.735 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -105.91, 129.83 APE9-dihe-in -107.25, 158.29 APE8-dihe-in -77.21, 88.15 APE8-rot-na 26.6 APE67-dihe-in -78.48, -3.49 -49.13, -44.82 APE12-dist-na 19.991 APE11-dist-na 15.346 APE10-dist-na 18.074 APE9-dist-na 7.513 None PTR393 PTR393 XRAY 2.255 0.177 0.213 A 272 258 10 0 0 0 [[242, 495]] 1.0 8i7z Homo sapiens TYR_ABL1_HUMAN TYR 2.3e-100 341.2 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 4YC8A P00519 233 501 1130.0 4B7:601 Type1.5_Front Inactive DFGinter 9.254 9.479 None DFGAsp-rot-out -68.71, 128.66 -122.3, 46.03 51.01, 2.09 -98.31, 2.86 321.16, 121.85 -137.07, 20.9 out-none out 11.142 Saltbr-none 999.0 HRD-in -85.64, -50.32 70.16, -2.63 none-out-in SNCnoi out-in ActLoopNT-out 5.44 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -94.08, 143.55 APE9-dihe-in -125.76, 160.26 APE8-dihe-in -76.74, 87.45 APE8-rot-na 25.75 APE67-dihe-in -57.03, -17.99 -35.8, -54.26 APE12-dist-na 19.127 APE11-dist-na 14.45 APE10-dist-na 17.471 APE9-dist-na 6.747 None None None XRAY 2.9 0.199 0.24 A 287 259 10 0 0 0 [[242, 495]] 1.0 4yc8 Homo sapiens TYR_ABL1_HUMAN TYR 2.8e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 4YC8B P00519 233 502 1130.0 4B7:601 Type1.5_Front Inactive DFGinter 9.555 9.692 None DFGAsp-rot-out -74.12, 129.26 -121.25, 39.81 53.04, -9.3 -90.85, -3.87 317.47, 128.16 -153.9, 45.6 out-none out 10.822 Saltbr-none 999.0 HRD-in -86.46, -51.93 71.35, -5.5 none-out-in SNCnoi out-in ActLoopNT-out 5.444 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -108.97, 118.68 APE9-dihe-in -109.17, 158.88 APE8-dihe-in -76.82, 85.24 APE8-rot-na 25.02 APE67-dihe-in -65.91, -22.69 -34.29, -47.11 APE12-dist-na 19.669 APE11-dist-na 14.989 APE10-dist-na 17.785 APE9-dist-na 6.93 None None None XRAY 2.9 0.199 0.24 B 287 264 6 0 0 0 [[242, 495]] 1.0 4yc8 Homo sapiens TYR_ABL1_HUMAN TYR 2.8e-100 340.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 9KS5A P00519 233 500 1130.0 A1EG1:271 Type1.5_Front Inactive DFGinter 8.73 5.596 None DFGAsp-rot-out -72.67, 142.35 -137.94, 44.53 59.76, -14.4 -78.62, -20.52 286.29, 105.37 -105.91, 20.09 in-na in 9.005 Saltbr-na 6.545 HRD-in -99.23, -52.74 79.62, -6.89 na-out-in SNCaoi out-in ActLoopNT-out 5.808 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -110.95, 133.03 APE9-dihe-in -106.8, 158.22 APE8-dihe-in -76.47, 95.45 APE8-rot-na 26.95 APE67-dihe-in -74.68, -6.25 -55.43, -44.13 APE12-dist-na 19.819 APE11-dist-na 15.248 APE10-dist-na 18.1 APE9-dist-na 7.545 None PTR393 A1EG1271,PTR393 XRAY 2.2 0.172 0.212 A 272 267 1 0 0 0 [[242, 495]] 1.0 9ks5 Homo sapiens TYR_ABL1_HUMAN TYR 1.7e-98 335.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_HUMAN 9KS5B P00519 233 500 1130.0 A1EG1:271 Type1.5_Front Inactive DFGinter 8.971 5.847 None DFGAsp-rot-out -69.26, 149.18 -127.32, 25.05 44.91, 11.91 -69.17, -24.35 300.43, 107.89 -96.85, 31.16 in-na in 8.96 Saltbr-na 6.29 HRD-out -120.48, 122.49 -83.95, -2.51 na-out-in SNCaoi out-in ActLoopNT-out 5.464 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -105.41, 141.36 APE9-dihe-in -120.7, 148.99 APE8-dihe-in -66.45, 102.07 APE8-rot-na 24.98 APE67-dihe-in -72.47, -9.8 -51.6, -47.65 APE12-dist-na 18.424 APE11-dist-na 14.058 APE10-dist-na 17.265 APE9-dist-na 6.892 None PTR393 A1EG1271,PTR393 XRAY 2.2 0.172 0.212 B 272 268 0 0 0 0 [[242, 495]] 1.0 9ks5 Homo sapiens TYR_ABL1_HUMAN TYR 1.7e-98 335.1 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL2 ABL2_HUMAN 3HMIA P42684 279 546 1182.0 DKI:1 Type1 Inactive DFGinter 9.164 4.826 None DFGAsp-rot-out -59.51, 142.63 -137.26, 25.26 50.98, 22.53 -75.0, 160.51 298.16, 114.52 70.44, 20.34 in-in in 8.257 Saltbr-in 2.503 HRD-in -92.76, -51.88 76.23, -2.59 in-out-in SNCioi out-in ActLoopNT-out 5.787 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -106.13, 129.9 APE9-dihe-in -117.54, 160.6 APE8-dihe-in -76.74, 91.54 APE8-rot-na 26.07 APE67-dihe-in -69.21, -5.26 -46.03, -53.32 APE12-dist-na 19.205 APE11-dist-na 14.374 APE10-dist-na 16.846 APE9-dist-na 6.851 None None None XRAY 1.65 0.19 0.234 A 292 268 0 0 0 0 [[288, 541]] 1.0 3hmi Homo sapiens TYR_ABL2_HUMAN TYR 2.4e-98 334.6 1 260 260 426 427 428 430 432 317 332 336 406 408 407 409 467 455 450 449 448 447 446 445 444 362 Tyrosine-protein kinase ABL2
TYR BMX BMX_HUMAN 3SXRA P51813 411 671 675.0 1N1:60001 Type1 Inactive DFGinter 7.882 8.167 BABtrans DFGAsp-rot-out -93.57, 121.18 -103.19, -9.04 59.74, -50.02 -51.22, 114.45 184.77, 74.21 62.74, 18.94 out-out out 10.805 Saltbr-out 7.559 HRD-out -99.0, 124.02 -80.22, -7.53 out-in-in SNCoii in-in ActLoopNT-in 2.835 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -95.14, 119.04 APE9-dihe-in -94.0, 160.01 APE8-dihe-in -48.96, 127.48 APE8-rot-na 331.52 APE67-dihe-in -68.66, -11.59 -65.07, -24.25 APE12-dist-na 10.029 APE11-dist-na 7.549 APE10-dist-na 12.042 APE9-dist-na 5.186 Q432K,Q611M,D617T,Q620E None None XRAY 2.4 0.189 0.231 A 268 257 4 0 0 0 [[417, 668]] 1.0 3sxr Homo sapiens TYR_BMX_HUMAN TYR 3.2e-93 317.8 1 260 260 553 554 555 557 559 445 460 464 533 535 534 536 594 582 577 576 575 574 573 572 571 490 Cytoplasmic tyrosine-protein kinase BMX
TYR BMX BMX_HUMAN 3SXRB P51813 411 671 675.0 1N1:60002 Type1 Inactive DFGinter 7.708 8.272 BABtrans DFGAsp-rot-out -92.79, 121.27 -96.68, -12.13 57.64, -61.14 -49.05, 115.54 186.98, 71.37 61.78, 19.24 out-out out 10.803 Saltbr-out 8.097 HRD-out -100.92, 124.05 -80.64, -7.7 out-in-in SNCoii in-in ActLoopNT-in 2.845 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -93.81, 125.57 APE9-dihe-in -101.37, 158.16 APE8-dihe-in -49.48, 128.1 APE8-rot-na 332.21 APE67-dihe-in -66.79, -11.14 -62.63, -27.73 APE12-dist-na 9.946 APE11-dist-na 7.447 APE10-dist-na 11.944 APE9-dist-na 5.19 Q432K,Q611M,D617T,Q620E None None XRAY 2.4 0.189 0.231 B 268 255 6 0 0 0 [[417, 668]] 1.0 3sxr Homo sapiens TYR_BMX_HUMAN TYR 3.2e-93 317.8 1 260 260 553 554 555 557 559 445 460 464 533 535 534 536 594 582 577 576 575 574 573 572 571 490 Cytoplasmic tyrosine-protein kinase BMX
TYR BMX BMX_HUMAN 3SXSA P51813 411 671 675.0 PP2:60001 Type1 Inactive DFGinter 8.876 7.889 BABtrans DFGAsp-rot-out -95.61, 121.24 -113.83, -1.35 62.76, 11.54 -56.54, 124.12 176.46, 76.51 70.61, 15.34 out-out out 10.716 Saltbr-out 10.788 HRD-out -98.32, 130.38 -82.0, -12.25 out-in-in SNCoii in-in ActLoopNT-in 2.877 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -91.4, 107.31 APE9-dihe-in -93.49, 162.66 APE8-dihe-in -48.34, 121.12 APE8-rot-na 328.7 APE67-dihe-in -67.4, -11.35 -59.38, -25.39 APE12-dist-na 10.326 APE11-dist-na 7.505 APE10-dist-na 12.208 APE9-dist-na 5.385 Q432K,Q611M,D617T,Q620E None None XRAY 1.89 0.18 0.209 A 268 261 0 0 0 0 [[417, 668]] 1.0 3sxs Homo sapiens TYR_BMX_HUMAN TYR 3.2e-93 317.8 1 260 260 553 554 555 557 559 445 460 464 533 535 534 536 594 582 577 576 575 574 573 572 571 490 Cytoplasmic tyrosine-protein kinase BMX
TYR BMX BMX_HUMAN 6I99A P51813 411 671 675.0 H88:60701 Type1 Inactive DFGinter 10.504 7.133 BABtrans DFGAsp-rot-out -92.78, 130.3 -132.82, 14.07 63.72, 6.85 -70.86, 131.07 175.95, 70.63 64.29, 18.34 out-out out 11.691 Saltbr-out 8.531 HRD-out -100.62, 121.88 -82.1, -7.03 out-in-in SNCoii in-in ActLoopNT-in 3.12 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -90.26, 112.05 APE9-dihe-in -95.39, 166.08 APE8-dihe-in -53.58, 127.81 APE8-rot-na 330.45 APE67-dihe-in -65.74, -5.97 -74.9, -17.09 APE12-dist-na 9.895 APE11-dist-na 7.345 APE10-dist-na 11.897 APE9-dist-na 5.44 Q432K,Q611M,D617T,Q620E None None XRAY 2.001 0.234 0.259 A 278 261 0 0 0 0 [[417, 668]] 1.0 6i99 Homo sapiens TYR_BMX_HUMAN TYR 3.6e-93 317.6 1 260 260 553 554 555 557 559 445 460 464 533 535 534 536 594 582 577 576 575 574 573 572 571 490 Cytoplasmic tyrosine-protein kinase BMX
TYR BMX BMX_HUMAN 6I99B P51813 411 671 675.0 H88:60701 Type1 Inactive DFGinter 9.251 7.233 BABtrans DFGAsp-rot-out -90.14, 131.24 -131.91, 13.25 64.23, 7.13 -71.54, 128.59 176.43, 70.05 63.87, 19.15 out-out out 10.23 Saltbr-out 9.251 HRD-out -99.74, 124.37 -81.83, -9.5 out-in-in SNCoii in-in ActLoopNT-in 3.066 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -90.48, 114.54 APE9-dihe-in -91.05, 166.61 APE8-dihe-in -52.06, 126.92 APE8-rot-na 330.29 APE67-dihe-in -65.72, -7.18 -74.8, -16.87 APE12-dist-na 10.048 APE11-dist-na 7.696 APE10-dist-na 11.898 APE9-dist-na 5.161 Q432K,Q611M,D617T,Q620E None None XRAY 2.001 0.234 0.259 B 278 261 0 0 0 0 [[417, 668]] 1.0 6i99 Homo sapiens TYR_BMX_HUMAN TYR 3.6e-93 317.6 1 260 260 553 554 555 557 559 445 460 464 533 535 534 536 594 582 577 576 575 574 573 572 571 490 Cytoplasmic tyrosine-protein kinase BMX
TYR BTK BTK_HUMAN 5XYZA Q06187 394 656 659.0 GYL:701 Type1 Inactive DFGinter 9.347 8.304 BABtrans DFGAsp-rot-out -99.77, 139.1 -95.47, 13.14 59.38, -9.07 -102.26, 131.3 176.17, 60.97 88.39, 12.77 out-out out 11.578 Saltbr-out 9.255 HRD-in -78.14, -61.12 90.65, -27.42 out-out-none SNCoon out-none ActLoopNT-out 5.228 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 77.34 APE8-dihe-in -83.17, 111.34 APE8-rot-na 20.92 APE67-dihe-in -73.15, -5.2 -57.61, -54.06 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.495 None None None XRAY 2.64 0.268 0.326 A 265 230 33 0 0 14 [[402, 653]] 1.0 5xyz Homo sapiens TYR_BTK_HUMAN TYR 5.7e-93 316.9 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 5XYZB Q06187 394 656 659.0 GYL:701 Type1 Inactive DFGinter 9.433 8.075 BABtrans DFGAsp-rot-out -80.9, 137.65 -92.66, -0.21 64.02, -9.21 -77.59, 136.6 176.7, 69.08 72.83, 36.08 out-out out 11.387 Saltbr-out 9.674 HRD-in -68.79, -59.6 106.37, -54.65 out-out-none SNCoon out-none ActLoopNT-out 5.327 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 75.53 APE8-dihe-in -66.49, 110.19 APE8-rot-na 22.3 APE67-dihe-in -70.95, -22.66 -57.21, -50.35 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 6.656 None None None XRAY 2.64 0.268 0.326 B 265 234 29 0 0 14 [[402, 653]] 1.0 5xyz Homo sapiens TYR_BTK_HUMAN TYR 5.7e-93 316.9 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 7YC9A Q06187 395 658 659.0 IS4:701 Type1 Inactive DFGinter 8.002 8.789 BABtrans DFGAsp-rot-out -86.32, 131.84 -104.1, 6.91 55.99, 40.31 -65.2, 125.85 176.47, 71.74 60.46, 29.78 out-out out 11.714 Saltbr-out 13.168 HRD-in -89.69, -58.41 77.25, -3.96 out-out-in SNCooi out-in ActLoopNT-out 8.711 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -112.07, 157.14 APE9-dihe-in -156.9, 156.06 APE8-dihe-in -80.91, 97.28 APE8-rot-na 28.13 APE67-dihe-in -74.5, -5.29 -49.69, -51.23 APE12-dist-na 18.249 APE11-dist-na 16.172 APE10-dist-na 13.526 APE9-dist-na 6.316 None None None XRAY 1.4 0.167 0.187 A 269 264 0 0 0 0 [[402, 653]] 1.0 7yc9 Homo sapiens TYR_BTK_HUMAN TYR 6.1e-93 316.9 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 3OCTA Q06187 394 656 659.0 1N1:663 Type1 Inactive DFGinter 9.551 8.047 BABtrans DFGAsp-rot-out -83.49, 139.01 -103.95, 15.92 57.03, 7.8 -87.02, 132.92 181.28, 97.3 77.87, 26.97 in-out in 9.203 Saltbr-out 7.745 HRD-in -70.28, -48.13 67.57, -13.36 out-out-none SNCoon out-none ActLoopNT-out 5.38 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 95.42 APE8-dihe-in -60.66, 106.57 APE8-rot-na 28.18 APE67-dihe-in -77.0, -13.84 -55.35, -41.2 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 5.71 V555R None None XRAY 1.95 0.199 0.251 A 265 244 19 0 0 14 [[402, 653]] 1.0 3oct Homo sapiens TYR_BTK_HUMAN TYR 2.4e-93 318.2 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_HUMAN 6NFIA Q06187 392 659 659.0 KLP:701 Type1 Inactive DFGinter 9.143 7.996 None DFGAsp-rot-out -88.38, 102.06 -66.25, -30.62 59.43, -36.53 -22.04, 98.6 180.01, 49.84 74.77, 999.0 out-out out 10.792 Saltbr-out 7.783 HRD-in -72.39, -52.0 75.98, -4.69 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 84.4 APE9-dihe-in -72.68, 133.55 APE8-dihe-in -78.11, 68.48 APE8-rot-na 34.66 APE67-dihe-in -67.64, -17.9 -60.47, -41.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.432 None None None XRAY 2.41 0.22 0.248 A 268 243 25 0 0 16 [[402, 653]] 1.0 6nfi Homo sapiens TYR_BTK_HUMAN TYR 6e-93 316.9 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR CSK CSK_HUMAN 1BYGA P41240 187 448 450.0 STU:501 Type1 Inactive DFGinter 10.86 7.923 BABtrans DFGAsp-rot-out -99.17, 153.06 -105.84, -7.01 67.94, 21.41 -68.56, 146.18 156.4, 90.07 -161.79, 133.09 out-out out 14.775 Saltbr-out 12.646 HRD-in -79.54, -44.6 72.05, -5.51 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 126.52 APE8-dihe-in -71.25, 96.92 APE8-rot-na 16.81 APE67-dihe-in -75.84, -8.12 -42.46, -43.57 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.292 None None None XRAY 2.4 0.199 0.287 A 278 246 16 0 0 12 [[195, 442]] 1.0 1byg Homo sapiens TYR_CSK_HUMAN TYR 1.2e-87 299.5 1 260 260 331 332 333 335 337 222 236 240 311 313 312 314 368 356 351 350 349 348 347 346 345 267 Tyrosine-protein kinase CSK
TYR DDR1 DDR1_HUMAN 6Y23A Q08345 574 907 913.0 No_ligand No_ligand Inactive DFGinter 10.153 7.308 None DFGAsp-rot-out -140.3, -158.95 -155.89, 34.86 48.85, 52.7 -96.49, -19.82 306.08, 111.29 -54.16, -38.8 in-out in 7.431 Saltbr-out 4.303 HRD-in -69.02, -55.97 80.69, 2.43 out-out-in SNCooi out-in ActLoopNT-out 17.592 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -133.93, 116.48 APE9-dihe-in -127.74, 145.71 APE8-dihe-in -88.51, 68.54 APE8-rot-na 35.64 APE67-dihe-in -68.64, -17.14 -58.48, -33.24 APE12-dist-na 999.0 APE11-dist-na 12.248 APE10-dist-na 7.88 APE9-dist-na 7.176 Y569F,Y586F None None XRAY 2.58 0.228 0.27 A 350 305 27 0 0 3 [[610, 907]] 1.0 6y23 Homo sapiens TYR_DDR1_HUMAN TYR 2.3e-92 315.0 1 260 260 783 784 785 787 789 655 672 676 763 765 764 766 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR DDR1 DDR1_HUMAN 6Y23B Q08345 574 910 913.0 No_ligand No_ligand Inactive DFGinter 10.177 7.489 None DFGAsp-rot-out -147.65, -164.17 -143.7, 24.01 51.14, 77.13 -83.51, -17.89 309.63, 115.78 -53.01, -42.7 in-out in 7.401 Saltbr-out 4.538 HRD-in -62.79, -53.56 80.0, -6.1 out-out-none SNCoon out-none ActLoopNT-out 17.396 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 122.54 APE9-dihe-in -139.37, 143.31 APE8-dihe-in -88.22, 70.91 APE8-rot-na 34.24 APE67-dihe-in -65.16, -14.5 -56.89, -35.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 7.79 APE9-dist-na 7.245 Y569F,Y586F None None XRAY 2.58 0.228 0.27 B 350 301 30 0 0 5 [[610, 907]] 1.0 6y23 Homo sapiens TYR_DDR1_HUMAN TYR 2.3e-92 315.0 1 260 260 783 784 785 787 789 655 672 676 763 765 764 766 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR DDR1 DDR1_HUMAN 6Y23C Q08345 574 911 913.0 No_ligand No_ligand Inactive DFGinter 10.326 7.424 None DFGAsp-rot-out -131.36, -161.95 -146.38, 29.72 55.51, -3.32 -92.15, -18.74 310.61, 115.72 -49.18, -37.85 in-out in 7.603 Saltbr-out 5.078 HRD-in -65.34, -54.8 81.25, 2.61 out-out-none SNCoon out-none ActLoopNT-out 17.518 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 131.97 APE9-dihe-in -138.28, 145.82 APE8-dihe-in -85.36, 72.32 APE8-rot-na 34.45 APE67-dihe-in -71.14, -17.59 -62.42, -29.77 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 8.108 APE9-dist-na 7.111 Y569F,Y586F None None XRAY 2.58 0.228 0.27 C 350 305 33 0 0 5 [[610, 907]] 1.0 6y23 Homo sapiens TYR_DDR1_HUMAN TYR 2.3e-92 315.0 1 260 260 783 784 785 787 789 655 672 676 763 765 764 766 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR DDR1 DDR1_HUMAN 6BRJA Q08345 605 913 913.0 VX6:60901 Type1 Inactive DFGinter 9.842 6.444 None DFGAsp-rot-out -75.98, 130.59 -108.73, 22.4 56.75, -10.93 -131.46, 172.46 67.8, 95.77 -125.27, 159.76 in-in in 8.607 Saltbr-in 2.475 HRD-in -69.59, -46.48 76.5, -9.43 in-out-in SNCioi out-in ActLoopNT-out 18.162 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -74.43, 114.86 APE9-dihe-in -119.04, 131.61 APE8-dihe-in -82.29, 70.03 APE8-rot-na 39.02 APE67-dihe-in -70.78, -15.74 -55.16, -32.48 APE12-dist-na 18.237 APE11-dist-na 14.849 APE10-dist-na 11.084 APE9-dist-na 7.365 None None None XRAY 2.231 0.189 0.223 A 351 274 35 0 0 0 [[610, 907]] 1.0 6brj Homo sapiens TYR_DDR1_HUMAN TYR 2.3e-92 315.0 1 260 260 783 784 785 787 789 655 672 676 763 765 764 766 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR DDR1 DDR1_HUMAN 6BSDA Q08345 604 912 913.0 1N1:60901 Type1 Inactive DFGinter 9.948 9.844 None DFGAsp-rot-out -87.87, 155.34 -64.16, -24.42 54.63, -23.83 174.69, 170.82 68.3, 89.44 55.93, 999.0 in-in in 8.37 Saltbr-in 2.735 HRD-in -61.68, -56.93 83.98, -4.33 in-out-in SNCioi out-in ActLoopNT-out 19.848 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -66.74, 115.57 APE9-dihe-in -116.16, 127.65 APE8-dihe-in -81.76, 68.68 APE8-rot-na 34.21 APE67-dihe-in -66.93, -20.25 -61.43, -30.39 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.146 None None None XRAY 2.606 0.186 0.255 A 351 278 31 0 0 2 [[610, 907]] 1.0 6bsd Homo sapiens TYR_DDR1_HUMAN TYR 2.3e-92 315.0 1 260 260 783 784 785 787 789 655 672 676 763 765 764 766 825 813 808 807 806 805 804 803 802 702 Epithelial discoidin domain-containing receptor 1
TYR EGFR EGFR_HUMAN 8H7XB P00533 697 1018 1210.0 No_ligand No_ligand Inactive DFGinter 8.474 4.539 None DFGAsp-rot-out -64.56, 138.69 -118.16, 46.75 59.26, -13.66 -84.7, 147.88 264.74, 132.9 65.94, 48.18 in-in in 7.861 Saltbr-in 2.743 HRD-in -95.26, -40.89 71.41, -6.98 in-out-none SNCion out-none ActLoopNT-out 5.284 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 134.76 APE8-dihe-in -79.73, 83.74 APE8-rot-na 34.28 APE67-dihe-in -52.0, -45.23 -70.34, -44.7 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 7.766 T790M,C797S None None XRAY 3.404 0.189 0.256 B 330 304 7 0 0 7 [[712, 970]] 1.0 8h7x Homo sapiens TYR_EGFR_HUMAN TYR 6.4e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5XGNB P00533 697 1019 1210.0 No_ligand No_ligand Inactive DFGinter 8.875 4.226 None DFGAsp-rot-out -66.63, 139.03 -107.84, 34.93 45.91, -3.75 -81.79, 142.31 255.34, 148.71 68.34, 31.51 in-in in 7.665 Saltbr-in 3.035 HRD-in -69.88, -38.92 70.25, -6.15 in-out-out SNCioo out-out ActLoopNT-out 5.544 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out 59.97, 52.07 APE9-dihe-in -79.54, 147.42 APE8-dihe-in -94.06, 88.44 APE8-rot-na 27.93 APE67-dihe-in -64.82, -35.28 -54.4, -44.67 APE12-dist-na 12.386 APE11-dist-na 15.391 APE10-dist-na 15.977 APE9-dist-na 7.966 T790M,C797S None None XRAY 3.0 0.222 0.251 B 331 308 5 0 0 4 [[712, 970]] 1.0 5xgn Homo sapiens TYR_EGFR_HUMAN TYR 6.5e-88 300.5 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2JITB P00533 697 1018 1210.0 No_ligand No_ligand Inactive DFGinter 8.643 4.268 None DFGAsp-rot-out -65.09, 133.17 -114.41, 36.11 63.51, -13.76 -84.27, 149.81 251.72, 154.26 60.91, 22.91 in-in in 8.03 Saltbr-in 3.164 HRD-in -71.83, -62.45 88.36, -10.04 in-out-in SNCioi out-in ActLoopNT-out 4.332 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -76.87, 136.57 APE9-dihe-in -138.24, 154.81 APE8-dihe-in -91.0, 80.78 APE8-rot-na 356.06 APE67-dihe-in -73.95, 11.71 -56.2, -43.16 APE12-dist-na 15.983 APE11-dist-na 15.773 APE10-dist-na 15.968 APE9-dist-na 7.412 T790M None None XRAY 3.1 0.209 0.249 B 327 312 0 0 0 0 [[712, 970]] 1.0 2jit Homo sapiens TYR_EGFR_HUMAN TYR 8.3e-88 300.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 2JIUB P00533 695 1004 1210.0 No_ligand No_ligand Inactive DFGinter 8.912 4.352 None DFGAsp-rot-out -62.48, 140.76 -118.63, 55.68 59.73, -12.58 -100.13, 143.92 258.8, 146.55 62.94, 28.63 in-in in 8.076 Saltbr-in 2.959 HRD-in -72.84, -64.99 94.58, -35.5 in-in-in SNCiii in-in ActLoopNT-in 3.489 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -56.69, 118.33 APE9-dihe-in -133.73, 161.67 APE8-dihe-in -92.78, 73.55 APE8-rot-na 15.24 APE67-dihe-in -66.9, -25.87 -50.11, -38.12 APE12-dist-na 16.383 APE11-dist-na 15.152 APE10-dist-na 16.405 APE9-dist-na 7.624 T790M None None XRAY 3.05 0.214 0.277 B 328 310 0 0 0 0 [[712, 970]] 1.0 2jiu Homo sapiens TYR_EGFR_HUMAN TYR 8.4e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4G5PB P00533 697 1018 1210.0 No_ligand No_ligand Inactive DFGinter 8.694 4.058 None DFGAsp-rot-out -102.27, 130.04 -119.39, 11.63 70.35, -19.05 -56.23, 139.55 268.64, 132.98 83.16, 48.09 in-in in 7.531 Saltbr-in 2.909 HRD-in -73.51, -36.65 75.01, -67.24 in-out-none SNCion out-none ActLoopNT-out 5.511 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 136.61 APE9-dihe-in -136.04, 152.17 APE8-dihe-in -101.09, 85.15 APE8-rot-na 34.16 APE67-dihe-in -61.97, -21.6 -60.83, -40.83 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 16.343 APE9-dist-na 8.971 T790M None None XRAY 3.17 0.247 0.323 B 330 303 8 0 0 8 [[712, 970]] 1.0 4g5p Homo sapiens TYR_EGFR_HUMAN TYR 8.5e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 3IKAB P00533 697 1017 1210.0 No_ligand No_ligand Inactive DFGinter 8.717 4.604 None DFGAsp-rot-out -75.22, 143.75 -113.63, 39.19 61.57, -14.51 -87.68, 145.68 264.7, 149.87 65.59, 19.15 in-in in 7.748 Saltbr-in 2.721 HRD-in -71.43, -56.54 82.98, -12.02 in-out-in SNCioi out-in ActLoopNT-out 5.388 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -70.44, 137.59 APE9-dihe-in -139.25, 153.6 APE8-dihe-in -85.59, 76.58 APE8-rot-na 26.0 APE67-dihe-in -74.82, -10.46 -52.9, -35.6 APE12-dist-na 16.909 APE11-dist-na 15.822 APE10-dist-na 16.726 APE9-dist-na 7.764 T790M None None XRAY 2.9 0.21 0.257 B 331 310 2 0 0 2 [[712, 970]] 1.0 3ika Homo sapiens TYR_EGFR_HUMAN TYR 8.6e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 4WD5B P00533 697 1016 1210.0 No_ligand No_ligand Inactive DFGinter 9.248 4.425 None DFGAsp-rot-out -72.57, 139.36 -100.73, 10.04 50.49, 0.82 -62.48, 143.44 260.7, 137.62 58.63, 39.1 in-out in 7.729 Saltbr-out 3.739 HRD-out -90.94, 114.01 -64.78, -40.5 out-out-in SNCooi out-in ActLoopNT-out 4.978 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -60.44, 137.91 APE9-dihe-in -137.14, 159.08 APE8-dihe-in -84.32, 85.1 APE8-rot-na 36.97 APE67-dihe-in -61.6, -40.36 -63.96, -40.18 APE12-dist-na 16.585 APE11-dist-na 15.83 APE10-dist-na 16.945 APE9-dist-na 8.836 T790M None None XRAY 3.3 0.211 0.239 B 331 304 5 0 0 5 [[712, 970]] 1.0 4wd5 Homo sapiens TYR_EGFR_HUMAN TYR 8.6e-88 300.1 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 9U91A P00533 703 983 1210.0 A1EOG:61101 Type1 Inactive DFGinter 8.618 6.381 None DFGAsp-rot-out -69.5407, 134.9974 -109.0163, 23.0847 41.1052, -6.1685 -71.8092, 151.5532 304.8441, 101.3226 61.4913, 33.383 out-out out 10.414 Saltbr-out 5.296 HRD-out -80.5336, 124.7514 -93.4253, 8.4937 out-out-out SNCooo out-out ActLoopNT-out 5.427 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaaa APE10-dihe-out -66.7297, -40.7755 APE9-dihe-in -114.0514, 123.748 APE8-dihe-in -81.4116, 72.3693 APE8-rot-na 27.6912 APE67-dihe-in -82.6482, -15.7003 -61.9955, -21.1708 APE12-dist-na 19.048 APE11-dist-na 18.91 APE10-dist-na 17.507 APE9-dist-na 8.314 T790M,C797S,V948R None None XRAY 3.2 0.231 0.274 A 344 269 7 0 0 7 [[712, 970]] 1.0 9u91 Homo sapiens TYR_EGFR_HUMAN TYR 1e-83 286.8 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR EGFR EGFR_HUMAN 5UWDA P00533 702 984 1210.0 8OV:9001 Type1 Inactive DFGinter 8.718 6.883 None DFGAsp-rot-in -103.03, 102.14 -79.54, 67.3 188.81, 27.29 -112.01, -2.59 296.52, 123.95 -53.45, -42.68 out-out out 12.173 Saltbr-out 13.169 HRD-in -62.38, -44.86 62.12, -14.75 out-out-none SNCoon out-none ActLoopNT-out 9.302 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 33.47 APE9-dihe-in -110.69, 126.69 APE8-dihe-in -92.9, 52.09 APE8-rot-na 21.1 APE67-dihe-in -67.65, -3.97 -43.65, -47.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 14.321 APE9-dist-na 9.235 T790M,L858R,V948R None None XRAY 3.06 0.216 0.28 A 329 271 12 0 0 12 [[712, 970]] 1.0 5uwd Homo sapiens TYR_EGFR_HUMAN TYR 6.6e-87 297.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR IGF1R IGF1R_HUMAN 1M7NA P08069 982 1286 1367.0 No_ligand No_ligand Inactive DFGinter 8.164 7.514 None DFGAsp-rot-out -63.65, 150.56 -83.71, 161.97 55.77, -50.2 -57.58, 152.8 77.55, 99.86 65.02, 30.98 in-out in 9.867 Saltbr-out 8.828 HRD-in -83.45, -42.46 69.8, -16.63 out-out-in SNCooi out-in ActLoopNT-out 17.622 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -66.63, 113.99 APE9-dihe-in -128.05, 145.23 APE8-dihe-in -84.3, 65.47 APE8-rot-na 35.92 APE67-dihe-in -74.19, -1.69 -49.75, -32.81 APE12-dist-na 23.243 APE11-dist-na 19.123 APE10-dist-na 15.076 APE9-dist-na 7.467 None None None XRAY 2.7 0.229 0.294 A 322 299 6 0 0 0 [[999, 1268]] 1.0 1m7n Homo sapiens TYR_IGF1R_HUMAN TYR 2.4e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 1M7NB P08069 982 1286 1367.0 No_ligand No_ligand Inactive DFGinter 9.13 7.337 None DFGAsp-rot-out -73.47, 167.84 -87.9, 168.41 38.43, -59.63 -62.8, 156.56 81.22, 124.1 55.25, 47.18 in-out in 9.829 Saltbr-out 8.107 HRD-in -100.99, -42.57 66.39, -13.05 out-out-in SNCooi out-in ActLoopNT-out 17.68 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -84.27, 123.84 APE9-dihe-in -122.55, 149.6 APE8-dihe-in -77.03, 59.62 APE8-rot-na 36.33 APE67-dihe-in -67.03, 6.96 -40.27, -45.78 APE12-dist-na 22.981 APE11-dist-na 18.942 APE10-dist-na 15.815 APE9-dist-na 7.184 None None None XRAY 2.7 0.229 0.294 B 322 299 6 0 0 0 [[999, 1268]] 1.0 1m7n Homo sapiens TYR_IGF1R_HUMAN TYR 2.4e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 1P4OA P08069 978 1285 1367.0 No_ligand No_ligand Inactive DFGinter 8.937 7.453 None DFGAsp-rot-out -75.61, 161.81 -88.19, 167.58 49.8, -49.66 -62.75, 158.69 79.74, 92.2 58.69, 28.18 in-out in 9.669 Saltbr-out 8.161 HRD-in -85.36, -54.81 81.1, -18.95 out-out-in SNCooi out-in ActLoopNT-out 17.814 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -75.47, 124.06 APE9-dihe-in -124.38, 139.88 APE8-dihe-in -82.49, 64.57 APE8-rot-na 36.92 APE67-dihe-in -73.19, -6.91 -50.14, -35.0 APE12-dist-na 22.275 APE11-dist-na 18.248 APE10-dist-na 14.541 APE9-dist-na 7.274 E1097A,E1099A None None XRAY 1.5 0.209 0.236 A 322 308 0 0 0 0 [[999, 1268]] 1.0 1p4o Homo sapiens TYR_IGF1R_HUMAN TYR 2.4e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR IGF1R IGF1R_HUMAN 1P4OB P08069 977 1290 1367.0 No_ligand No_ligand Inactive DFGinter 8.973 7.373 None DFGAsp-rot-out -74.95, 163.69 -90.41, 168.58 49.82, -51.04 -63.57, 158.6 80.11, 88.87 59.26, 26.84 in-out in 9.712 Saltbr-out 8.134 HRD-in -85.93, -55.48 81.68, -17.46 out-out-in SNCooi out-in ActLoopNT-out 17.871 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -71.53, 126.34 APE9-dihe-in -129.41, 143.63 APE8-dihe-in -82.98, 67.29 APE8-rot-na 36.94 APE67-dihe-in -73.89, -4.17 -52.36, -34.34 APE12-dist-na 22.458 APE11-dist-na 18.39 APE10-dist-na 14.695 APE9-dist-na 7.171 E1097A,E1099A None None XRAY 1.5 0.209 0.236 B 322 314 0 0 0 0 [[999, 1268]] 1.0 1p4o Homo sapiens TYR_IGF1R_HUMAN TYR 2.4e-95 324.8 1 260 260 1152 1153 1154 1156 1158 1033 1050 1054 1132 1134 1133 1135 1194 1182 1177 1176 1175 1174 1173 1172 1171 1080 Insulin-like growth factor 1 receptor
TYR KDR VGFR2_HUMAN 1Y6AA P35968 820 1167 1356.0 AAZ:60201 Type1 Inactive DFGinter 8.666 8.838 None DFGAsp-rot-out -73.14, 116.72 -103.71, 73.1 344.12, -68.77 -178.89, 999.0 25.84, 61.42 999.0, 999.0 in-in in 7.47 Saltbr-in 2.801 HRD-in -83.04, -53.13 81.96, -16.64 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -20.95 APE8-rot-na 328.99 APE67-dihe-in -63.85, -16.51 -63.27, -26.51 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.1 0.196 0.217 A 366 261 87 0 0 20 [[834, 1162]] 1.0 1y6a Homo sapiens TYR_KDR_HUMAN TYR 2.7e-99 337.7 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
TYR KDR VGFR2_HUMAN 1Y6BA P35968 819 1168 1356.0 AAX:60201 Type1 Inactive DFGinter 8.959 8.691 None DFGAsp-rot-out -70.35, 112.74 -90.68, -29.02 38.74, -15.31 -42.32, 999.0 351.89, 106.67 999.0, 999.0 in-in in 7.482 Saltbr-in 2.957 HRD-in -82.96, -58.21 87.46, -12.31 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 69.65 APE8-rot-na 33.76 APE67-dihe-in -65.54, -15.03 -63.36, -37.08 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 None None None XRAY 2.1 0.194 0.236 A 366 266 84 0 0 20 [[834, 1162]] 1.0 1y6b Homo sapiens TYR_KDR_HUMAN TYR 2.7e-99 337.7 1 260 260 1045 1046 1047 1049 1051 868 885 889 1025 1027 1026 1028 1087 1075 1070 1069 1068 1067 1066 1065 1064 917 Vascular endothelial growth factor receptor 2
TYR PTK2 FAK1_HUMAN 4EBWA Q05397 411 686 1052.0 0PF:700 Type1 Inactive DFGinter 10.52 8.023 None DFGAsp-rot-out -156.77, 167.19 -119.55, 38.35 51.17, 5.91 -154.8, 160.1 57.14, 97.67 -105.09, 155.15 in-in in 7.232 Saltbr-in 3.021 HRD-out -85.85, 108.83 -92.42, -13.42 in-none-none SNCinn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 105.2 APE9-dihe-in -103.42, 143.85 APE8-dihe-in -74.96, 72.04 APE8-rot-na 29.05 APE67-dihe-in -70.29, -24.24 -52.29, -39.56 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 17.857 APE9-dist-na 9.391 None None None XRAY 2.65 0.186 0.273 A 304 259 17 0 0 15 [[422, 678]] 1.0 4ebw Homo sapiens TYR_PTK2_HUMAN TYR 4.8e-93 317.2 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TYR ROR2 ROR2_HUMAN 3ZZWA Q01974 466 750 943.0 No_ligand No_ligand Pseudo DFGinter 10.345 8.07 None DFGAsp-rot-in -96.3, 113.42 -93.32, 36.02 210.77, -34.5 -147.08, 160.59 50.4, 103.61 174.45, -162.31 in-out in 8.469 Saltbr-out 4.596 HRD-in -47.14, -51.88 77.11, -23.02 out-out-in SNCooi out-in ActLoopNT-out 17.444 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -102.81, 114.23 APE9-dihe-in -109.27, 120.13 APE8-dihe-in -82.4, 68.78 APE8-rot-na 28.79 APE67-dihe-in -64.86, -16.77 -44.26, -50.32 APE12-dist-na 13.627 APE11-dist-na 12.242 APE10-dist-na 7.628 APE9-dist-na 7.665 None None None XRAY 2.9 0.19 0.247 A 289 269 16 0 0 0 [[473, 748]] 1.0 3zzw Homo sapiens TYR_ROR2_HUMAN TYR 5.5e-91 310.4 2 260 259 632 633 634 636 638 507 524 528 612 614 613 615 674 662 657 656 655 654 653 652 651 554 Tyrosine-protein kinase transmembrane receptor ROR2
TYR ROR2 ROR2_HUMAN 4GT4A Q01974 464 751 943.0 No_ligand No_ligand Pseudo DFGinter 9.614 6.483 None DFGAsp-rot-out -93.67, 118.8 -119.64, 62.63 52.73, 0.13 -106.27, -3.3 278.25, 67.29 61.48, 39.98 in-out in 8.533 Saltbr-out 3.871 HRD-out -75.16, 142.52 -112.65, 2.81 out-out-in SNCooi out-in ActLoopNT-out 16.314 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -79.46, 127.32 APE9-dihe-in -119.05, 136.77 APE8-dihe-in -80.2, 67.59 APE8-rot-na 30.63 APE67-dihe-in -67.7, -19.84 -54.55, -34.96 APE12-dist-na 15.894 APE11-dist-na 12.718 APE10-dist-na 10.239 APE9-dist-na 6.747 None None None XRAY 2.406 0.179 0.205 A 308 274 14 0 0 0 [[473, 748]] 1.0 4gt4 Homo sapiens TYR_ROR2_HUMAN TYR 6.9e-91 310.1 2 260 259 632 633 634 636 638 507 524 528 612 614 613 615 674 662 657 656 655 654 653 652 651 554 Tyrosine-protein kinase transmembrane receptor ROR2
TYR ROR2 ROR2_HUMAN 4GT4B Q01974 464 752 943.0 No_ligand No_ligand Pseudo DFGinter 10.193 7.582 None DFGAsp-rot-none -91.01, 100.94 -99.91, 70.26 999.0, 999.0 -110.46, -11.91 297.81, 174.51 61.14, 43.64 in-in in 8.881 Saltbr-in 2.975 HRD-in -71.57, -49.3 78.13, -12.79 in-out-in SNCioi out-in ActLoopNT-out 16.141 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -85.88, 120.55 APE9-dihe-in -112.46, 137.59 APE8-dihe-in -79.18, 69.28 APE8-rot-na 29.96 APE67-dihe-in -69.15, -20.22 -53.97, -34.39 APE12-dist-na 15.711 APE11-dist-na 12.448 APE10-dist-na 10.062 APE9-dist-na 6.755 None None None XRAY 2.406 0.179 0.205 B 308 273 16 0 0 0 [[473, 748]] 1.0 4gt4 Homo sapiens TYR_ROR2_HUMAN TYR 6.9e-91 310.1 2 260 259 632 633 634 636 638 507 524 528 612 614 613 615 674 662 657 656 655 654 653 652 651 554 Tyrosine-protein kinase transmembrane receptor ROR2
TYR SRC SRC_HUMAN 4MXXB P12931 261 536 536.0 DB8:60601 Type1 Inactive DFGinter 9.192 8.286 BABtrans DFGAsp-rot-out -85.22, 126.66 -111.4, 38.55 50.12, -35.74 -113.28, 121.97 179.79, 84.82 122.67, -27.99 out-out out 10.737 Saltbr-out 7.312 HRD-in -99.39, -46.07 76.64, -21.16 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 94.26 APE8-dihe-in -50.75, 100.65 APE8-rot-na 26.17 APE67-dihe-in -61.28, -28.71 -44.67, -43.48 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 5.954 A406T None None XRAY 2.6 0.213 0.276 B 286 260 16 0 0 16 [[270, 521]] 1.0 4mxx Homo sapiens TYR_SRC_HUMAN TYR 3.2e-94 321.0 1 260 260 406 407 408 410 412 298 313 317 386 388 387 389 447 435 430 429 428 427 426 425 424 342 Proto-oncogene tyrosine-protein kinase Src
TYR TEK TIE2_HUMAN 1FVRA Q02763 813 1121 1124.0 No_ligand No_ligand Inactive DFGinter 8.417 7.259 BABtrans DFGAsp-rot-out -70.32, 127.73 -127.01, 36.72 47.31, 12.52 -94.99, 138.29 184.97, 79.8 67.05, 29.11 out-out out 10.373 Saltbr-out 7.44 HRD-in -69.68, -50.63 81.63, -26.26 out-out-none SNCoon out-none ActLoopNT-out 5.117 ActLoopCT-none TYR APEdihe_nniai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 124.88 APE8-dihe-in -75.53, 55.91 APE8-rot-na 38.59 APE67-dihe-in -71.29, -9.41 -46.42, -37.9 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 8.515 None None None XRAY 2.2 0.195 0.225 A 327 299 10 0 0 4 [[824, 1094]] 1.0 1fvr Homo sapiens TYR_TEK_HUMAN TYR 8.6e-91 309.8 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
TYR TEK TIE2_HUMAN 1FVRB Q02763 813 1121 1124.0 No_ligand No_ligand Inactive DFGinter 8.59 7.184 BABtrans DFGAsp-rot-out -71.55, 125.08 -125.14, 43.48 47.62, 14.48 -101.19, 137.55 183.68, 81.8 68.42, 28.27 out-out out 10.101 Saltbr-out 7.6 HRD-in -66.4, -52.26 80.81, -19.06 out-out-none SNCoon out-none ActLoopNT-out 5.131 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, -27.62 APE9-dihe-in -107.96, 129.21 APE8-dihe-in -75.73, 57.96 APE8-rot-na 37.26 APE67-dihe-in -64.73, -13.95 -46.88, -41.75 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 17.261 APE9-dist-na 8.643 None None None XRAY 2.2 0.195 0.225 B 327 300 9 0 0 3 [[824, 1094]] 1.0 1fvr Homo sapiens TYR_TEK_HUMAN TYR 8.6e-91 309.8 1 260 260 981 982 983 985 987 855 872 876 961 963 962 964 1020 1008 1003 1002 1001 1000 999 998 997 903 Angiopoietin-1 receptor
CAMK AURKA AURKA_MOUSE 3DAJA P97477 118 379 395.0 FXG:60001 Type1 Inactive DFGinter 9.56 7.402 None DFGAsp-rot-out -134.29, 76.42 -147.47, -168.09 58.09, 23.4 -117.97, 39.39 298.8, 92.41 -105.61, 25.6 out-out out 12.111 Saltbr-out 11.144 HRD-out -117.62, 145.96 -85.7, -149.13 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 139.61 APE8-rot-in 314.8 APE67-dihe-in -53.82, -22.73 -58.61, -35.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 N164G,K218R,T278D,M280L None None XRAY 2.0 0.253 0.284 A 272 245 17 0 0 13 [[124, 374]] 1.0 3daj Mus musculus CAMK_AURKA_MOUSE CAMK 6.2e-80 274.2 1 256 256 264 265 266 268 270 153 172 176 244 246 245 247 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
TYR ABL1 ABL1_MOUSE 3DK7A P00520 233 502 1123.0 SX7:1 Type1 Inactive DFGinter 9.521 4.47 None DFGAsp-rot-out -65.94, 133.62 -136.37, 26.36 53.27, 1.48 -59.29, -46.94 277.65, 138.09 -96.98, 21.57 in-in in 7.766 Saltbr-in 2.793 HRD-in -90.33, -58.06 79.79, -1.99 in-out-in SNCioi out-in ActLoopNT-out 5.675 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -107.5, 130.75 APE9-dihe-in -114.11, 153.09 APE8-dihe-in -69.74, 90.62 APE8-rot-na 25.02 APE67-dihe-in -72.01, -11.59 -51.31, -42.54 APE12-dist-na 20.579 APE11-dist-na 15.929 APE10-dist-na 18.225 APE9-dist-na 7.447 T315I,L445P PTR393 PTR393 XRAY 2.01 0.216 0.242 A 277 266 4 0 0 0 [[242, 495]] 1.0 3dk7 Mus musculus TYR_ABL1_MOUSE TYR 2.7e-100 341.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 3DK6A P00520 233 502 1123.0 SX7:1 Type1 Inactive DFGinter 9.835 8.306 None DFGAsp-rot-out -61.57, 128.5 -127.52, 27.29 57.49, -6.44 -83.26, -21.75 331.68, 119.16 -112.49, 27.73 in-in in 7.974 Saltbr-in 2.893 HRD-in -91.42, -55.08 73.35, 1.27 in-out-in SNCioi out-in ActLoopNT-out 5.66 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -110.77, 134.59 APE9-dihe-in -117.57, 154.09 APE8-dihe-in -69.69, 91.12 APE8-rot-na 24.6 APE67-dihe-in -73.26, -8.23 -48.64, -44.69 APE12-dist-na 20.525 APE11-dist-na 15.941 APE10-dist-na 18.171 APE9-dist-na 7.39 Y253F,L445P PTR393 PTR393 XRAY 2.02 0.216 0.246 A 293 263 7 0 0 0 [[242, 495]] 1.0 3dk6 Mus musculus TYR_ABL1_MOUSE TYR 3.3e-101 343.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 3DK6B P00520 234 505 1123.0 SX7:2 Type1 Inactive DFGinter 9.607 8.211 None DFGAsp-rot-out -63.13, 129.74 -127.1, 39.65 56.63, -8.57 -91.94, -7.89 322.45, 123.44 -137.52, 35.5 in-none in 8.477 Saltbr-none 999.0 HRD-in -90.89, -55.29 76.04, -7.16 none-out-in SNCnoi out-in ActLoopNT-out 5.58 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -104.73, 139.41 APE9-dihe-in -127.03, 148.23 APE8-dihe-in -65.18, 97.87 APE8-rot-na 342.63 APE67-dihe-in -74.45, -10.42 -49.61, -43.27 APE12-dist-na 18.841 APE11-dist-na 14.184 APE10-dist-na 17.301 APE9-dist-na 6.943 Y253F,L445P PTR393 PTR393 XRAY 2.02 0.216 0.246 B 293 260 12 0 0 0 [[242, 495]] 1.0 3dk6 Mus musculus TYR_ABL1_MOUSE TYR 3.3e-101 343.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 3DK3A P00520 233 502 1123.0 SX7:1 Type1 Inactive DFGinter 9.037 4.534 None DFGAsp-rot-out -66.29, 133.89 -136.12, 20.26 55.83, -5.52 -58.29, -43.12 280.16, 137.15 -98.94, 20.71 in-in in 7.628 Saltbr-in 2.858 HRD-in -87.93, -54.51 76.79, -4.02 in-out-in SNCioi out-in ActLoopNT-out 5.681 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -104.14, 131.04 APE9-dihe-in -114.33, 156.79 APE8-dihe-in -71.32, 89.5 APE8-rot-na 25.37 APE67-dihe-in -70.0, -11.6 -49.65, -44.27 APE12-dist-na 20.741 APE11-dist-na 16.009 APE10-dist-na 18.29 APE9-dist-na 7.277 Y393F,L445P None None XRAY 2.02 0.213 0.248 A 293 266 4 0 0 0 [[242, 495]] 1.0 3dk3 Mus musculus TYR_ABL1_MOUSE TYR 1.4e-99 338.7 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 3DK3B P00520 233 505 1123.0 SX7:2 Type1 Inactive DFGinter 8.654 4.762 None DFGAsp-rot-out -66.35, 137.23 -141.11, 32.97 57.12, -3.35 -68.57, -40.89 274.02, 151.63 -104.05, 31.43 in-in in 7.726 Saltbr-in 2.728 HRD-in -97.18, -55.69 76.9, -3.17 in-out-in SNCioi out-in ActLoopNT-out 5.554 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -102.31, 136.08 APE9-dihe-in -118.61, 148.91 APE8-dihe-in -68.85, 95.72 APE8-rot-na 24.23 APE67-dihe-in -70.92, -12.54 -48.57, -45.29 APE12-dist-na 19.212 APE11-dist-na 14.55 APE10-dist-na 17.621 APE9-dist-na 7.002 Y393F,L445P None None XRAY 2.02 0.213 0.248 B 293 269 4 0 0 0 [[242, 495]] 1.0 3dk3 Mus musculus TYR_ABL1_MOUSE TYR 1.4e-99 338.7 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR BTK BTK_MOUSE 8S9FA P35991 392 659 659.0 1N1:801 Type1 Inactive DFGinter 9.738 8.477 BABtrans DFGAsp-rot-out -103.75, 162.9 -98.62, -12.56 301.91, 16.91 -74.46, 134.73 203.6, 82.29 75.53, 30.46 out-out out 11.325 Saltbr-out 8.457 HRD-out -78.16, 120.76 -71.26, -27.71 out-out-none SNCoon out-none ActLoopNT-out 5.464 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 89.3 APE8-rot-na 354.27 APE67-dihe-in -88.28, 1.83 -66.03, -37.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 L390G,Y551E,Y617P None None XRAY 2.6 0.244 0.284 A 279 254 14 0 0 14 [[402, 653]] 1.0 8s9f Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_MOUSE 8S9FB P35991 392 659 659.0 1N1:801 Type1 Inactive DFGinter 9.509 8.472 BABtrans DFGAsp-rot-out -108.61, 149.63 -109.15, 7.92 46.16, -6.54 -82.22, 131.91 185.43, 98.64 78.7, 27.48 out-out out 11.019 Saltbr-out 10.329 HRD-out -91.58, 112.75 -69.14, -29.29 out-out-none SNCoon out-none ActLoopNT-out 5.681 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 166.92 APE9-dihe-in -91.32, 115.75 APE8-dihe-in -71.7, 107.6 APE8-rot-na 25.58 APE67-dihe-in -83.25, -12.58 -54.13, -30.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 16.149 APE9-dist-na 18.604 L390G,Y551E,Y617P None None XRAY 2.6 0.244 0.284 B 279 255 13 0 0 12 [[402, 653]] 1.0 8s9f Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR MUSK MUSK_RAT 1LUFA Q62838 560 860 868.0 No_ligand No_ligand Inactive DFGinter 10.747 6.618 None DFGAsp-rot-in -156.55, -169.71 -170.83, 84.62 196.97, -6.9 -80.52, -3.72 280.77, 72.0 68.08, 27.29 in-in in 8.975 Saltbr-in 3.432 HRD-in -65.48, -48.59 74.12, -6.34 in-out-in SNCioi out-in ActLoopNT-out 15.566 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -55.03, 128.61 APE9-dihe-in -122.59, 147.16 APE8-dihe-in -78.26, 60.9 APE8-rot-na 36.06 APE67-dihe-in -61.04, -10.56 -37.4, -50.92 APE12-dist-na 999.0 APE11-dist-na 15.136 APE10-dist-na 11.63 APE9-dist-na 7.438 None None None XRAY 2.05 0.231 0.246 A 343 275 26 0 0 4 [[574, 857]] 1.0 1luf Rattus norvegicus TYR_MUSK_RAT TYR 2e-96 328.3 1 260 260 741 742 743 745 747 608 625 629 721 723 722 724 783 771 766 765 764 763 762 761 760 655 Muscle, skeletal receptor tyrosine protein kinase
CAMK SNF1 SNF1_YEAST 3MN3A P06782 50 320 633.0 No_ligand No_ligand Inactive DFGinter 7.447 8.274 None DFGAsp-rot-in -80.18, 112.84 -124.36, 94.11 182.7, -18.24 -159.22, 145.62 193.28, 71.33 -146.65, 68.27 out-out out 10.903 Saltbr-out 11.872 HRD-out -63.7, 131.62 -118.95, 125.24 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -138.22, 172.63 APE9-dihe-na -65.35, 169.45 APE8-dihe-in -66.59, 127.25 APE8-rot-out 173.28 APE67-dihe-in -71.29, -19.51 -53.41, -27.07 APE12-dist-out 14.54 APE11-dist-in 11.88 APE10-dist-out 14.64 APE9-dist-out 8.841 None None None XRAY 2.38 0.231 0.246 A 271 252 19 0 0 7 [[55, 306]] 1.0 3mn3 Saccharomyces cerevisiae CAMK_SNF1_YEAST CAMK 6.8e-92 313.4 1 256 256 194 195 196 198 200 84 103 107 174 176 175 177 234 221 216 215 214 213 212 211 210 133 Carbon catabolite-derepressing protein kinase
CAMK SAPK10 A0A238LNS4_9POAL 5WAXA A0A238LNS4 13 320 362.0 No_ligand No_ligand Inactive DFGinter 9.433 8.754 None DFGAsp-rot-in -95.22, 76.51 -86.03, 66.52 184.93, 15.07 -159.46, 159.08 66.57, 74.23 -158.49, 121.19 out-out out 10.455 Saltbr-out 10.338 HRD-out -62.64, 138.2 -125.04, 143.21 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 133.57 APE8-rot-out 178.64 APE67-dihe-in -48.8, -32.62 -63.74, -8.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.2 0.237 A 310 279 15 0 0 15 [[23, 279]] 1.0 5wax Saccharum officinarum CAMK_SAPK10_9POAL CAMK 1.9e-80 276.0 1 256 256 161 162 163 165 167 52 67 71 139 141 140 142 201 188 183 182 181 180 179 178 177 97 non-specific serine/threonine protein kinase
CAMK SAPK10 A0A238LNS4_9POAL 5WAXB A0A238LNS4 14 320 362.0 No_ligand No_ligand Inactive DFGinter 9.72 8.965 None DFGAsp-rot-none -90.88, 81.91 -92.01, 76.84 999.0, 999.0 -157.22, 160.01 61.41, 82.21 -156.89, 118.97 out-none out 10.574 Saltbr-none 999.0 HRD-out 57.72, -125.16 -51.83, -34.36 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -103.01, 91.32 APE9-dihe-na -96.06, 9.42 APE8-dihe-in -62.15, 131.43 APE8-rot-out 180.15 APE67-dihe-in -47.58, -34.71 -64.6, -7.6 APE12-dist-none 999.0 APE11-dist-out 17.654 APE10-dist-out 19.336 APE9-dist-out 14.094 None None None XRAY 2.0 0.2 0.237 B 310 274 18 0 0 12 [[23, 279]] 1.0 5wax Saccharum officinarum CAMK_SAPK10_9POAL CAMK 1.9e-80 276.0 1 256 256 161 162 163 165 167 52 67 71 139 141 140 142 201 188 183 182 181 180 179 178 177 97 non-specific serine/threonine protein kinase
CAMK SSP2 SNF1_SCHPO 3H4JB O74536 27 351 576.0 No_ligand No_ligand Inactive DFGinter 6.889 9.762 None DFGAsp-rot-out -123.85, 118.75 -132.48, 74.37 291.58, -38.5 -128.19, 27.87 291.57, 83.53 49.54, 50.74 out-out out 12.81 Saltbr-out 8.137 HRD-out -72.18, 56.45 -117.36, 20.63 out-out-out SNCooo out-out ActLoopNT-out 16.557 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -46.91, 136.15 APE9-dihe-na 102.12, -9.85 APE8-dihe-in -108.02, 143.53 APE8-rot-out 178.23 APE67-dihe-in -75.68, -14.71 -63.53, -27.64 APE12-dist-in 10.431 APE11-dist-in 11.859 APE10-dist-out 16.139 APE9-dist-out 9.354 None None None XRAY 2.8 0.22 0.257 B 336 325 0 0 0 0 [[34, 285]] 1.0 3h4j Schizosaccharomyces pombe CAMK_SSP2_SCHPO CAMK 1.8e-90 309.0 1 256 256 173 174 175 177 179 63 82 86 153 155 154 156 213 200 195 194 193 192 191 190 189 112 SNF1-like protein kinase ssp2
AGC TB0348O8470 Q582V7_TRYB2 9Z8KB Q582V7 54 347 406.0 No_ligand No_ligand Inactive DFGinter 4.787 10.505 None DFGAsp-rot-out -71.68, 124.57 -107.67, -28.59 268.28, -9.83 -125.91, 34.63 312.76, 87.28 -93.76, -164.0 in-in in 8.873 Saltbr-in 2.956 HRD-in -66.47, -46.77 68.54, -6.62 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -89.62 APE8-dihe-out -52.69, -45.07 APE8-rot-out 190.44 APE67-dihe-in -78.75, -15.67 -59.7, -24.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.297 None None None XRAY 2.05 0.197 0.235 B 362 271 23 0 0 23 [[61, 326]] 1.0 9z8k Trypanosoma brucei brucei AGC_TB0348O8470_TRYB2 AGC 4e-77 264.9 1 259 259 203 204 205 207 209 90 109 113 183 185 184 186 252 240 235 234 233 232 231 230 229 139 Serine/threonine-protein kinase, putative

All / DFGinter / All

Total number of chains: 27
Active chains: 0
Total number of genes: 12
Spatial label Dihedral label Number of Chains Percent Representative
DFGinter None 25 92.6% 3H4JB
DFGinter BABtrans 2 7.4% 8S9FB
All chains
Pymol session (all) Pymol script (all)
Representatives
Pymol session (repr) Pymol script (repr)
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label DFG-Asp_rot_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Asp
χ1,χ2		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
CAMK SRK2E SRK2E_ARATH 3UJGA Q940H6 20 318 362.0 No_ligand No_ligand Inactive DFGinter 7.568 7.802 None DFGAsp-rot-in 59.82, 78.75 -91.25, 162.66 201.18, -10.33 -45.68, -61.55 178.96, 56.58 -72.38, 37.27 out-out out 11.43 Saltbr-out 9.739 HRD-out 55.1, -126.57 -66.01, -15.12 out-out-out SNCooo out-out ActLoopNT-out 7.216 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -64.04, 142.08 APE9-dihe-na -75.28, -60.65 APE8-dihe-in -122.16, 75.37 APE8-rot-in 331.63 APE67-dihe-in -49.71, -30.19 -60.02, -24.28 APE12-dist-out 19.771 APE11-dist-out 19.693 APE10-dist-out 15.721 APE9-dist-out 14.72 D296A,E297A None None XRAY 2.6 0.209 0.238 A 361 290 5 0 0 0 [[21, 277]] 1.0 3ujg Arabidopsis thaliana CAMK_SRK2E_ARATH CAMK 2.4e-79 272.4 1 256 256 159 160 161 163 165 50 65 69 137 139 138 140 199 186 181 180 179 178 177 176 175 95 Serine/threonine-protein kinase SRK2E
CAMK SRK2E SRK2E_ARATH 3UDBA Q940H6 12 317 362.0 No_ligand No_ligand Inactive DFGinter 8.946 9.963 None DFGAsp-rot-in -96.71, 98.33 -99.5, 64.58 223.98, -38.79 -98.76, 177.69 315.85, 158.5 -146.95, -61.19 out-out out 10.482 Saltbr-out 8.442 HRD-out 65.08, 72.38 -56.81, -178.3 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 176.26 APE8-rot-out 78.91 APE67-dihe-in -55.61, -35.04 -55.27, -18.94 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S7A,S29A,S43A,C131A,C137A,C159A,S166A,T176A None None XRAY 2.567 0.238 0.259 A 317 275 15 0 0 15 [[21, 277]] 1.0 3udb Arabidopsis thaliana CAMK_SRK2E_ARATH CAMK 3.1e-77 265.4 1 256 256 159 160 161 163 165 50 65 69 137 139 138 140 199 186 181 180 179 178 177 176 175 95 Serine/threonine-protein kinase SRK2E
CAMK SRK2E SRK2E_ARATH 3UDBB Q940H6 12 317 362.0 No_ligand No_ligand Inactive DFGinter 9.458 9.004 None DFGAsp-rot-in -107.79, 64.97 -84.29, 91.48 188.21, 4.1 178.09, 129.52 67.29, 76.65 -128.86, 102.63 out-out out 10.315 Saltbr-out 9.084 HRD-out -47.3, 135.95 -119.13, -152.23 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 171.81 APE8-dihe-in -129.32, 159.05 APE8-rot-out 145.59 APE67-dihe-in -68.82, -38.77 -105.83, 9.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 15.484 S7A,S29A,S43A,C131A,C137A,C159A,S166A,T176A None None XRAY 2.567 0.238 0.259 B 317 278 14 0 0 14 [[21, 277]] 1.0 3udb Arabidopsis thaliana CAMK_SRK2E_ARATH CAMK 3.1e-77 265.4 1 256 256 159 160 161 163 165 50 65 69 137 139 138 140 199 186 181 180 179 178 177 176 175 95 Serine/threonine-protein kinase SRK2E
CAMK SRK2E SRK2E_ARATH 3UDBD Q940H6 12 317 362.0 No_ligand No_ligand Inactive DFGinter 9.791 9.667 None DFGAsp-rot-in -91.8, 111.78 -135.53, 46.38 223.25, -41.84 -101.81, -90.87 27.7, 109.09 154.77, -129.77 out-out out 10.345 Saltbr-out 9.362 HRD-out -58.99, 138.62 -118.26, 126.91 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 144.66 APE8-rot-out 79.39 APE67-dihe-in -35.53, -45.05 -73.71, -21.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S7A,S29A,S43A,C131A,C137A,C159A,S166A,T176A None None XRAY 2.567 0.238 0.259 D 317 279 15 0 0 15 [[21, 277]] 1.0 3udb Arabidopsis thaliana CAMK_SRK2E_ARATH CAMK 3.1e-77 265.4 1 256 256 159 160 161 163 165 50 65 69 137 139 138 140 199 186 181 180 179 178 177 176 175 95 Serine/threonine-protein kinase SRK2E
CAMK SRK2E SRK2E_ARATH 3UDBF Q940H6 12 317 362.0 No_ligand No_ligand Inactive DFGinter 9.606 8.997 None DFGAsp-rot-in -89.63, 118.14 -143.13, 62.81 203.55, 16.18 -97.7, -94.26 311.41, 167.87 124.81, -154.36 out-out out 10.468 Saltbr-out 9.53 HRD-out -149.35, 103.88 -79.53, -161.56 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 155.59 APE8-rot-out 148.18 APE67-dihe-in -48.65, -38.94 -78.23, -15.18 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 S7A,S29A,S43A,C131A,C137A,C159A,S166A,T176A None None XRAY 2.567 0.238 0.259 F 317 273 15 0 0 15 [[21, 277]] 1.0 3udb Arabidopsis thaliana CAMK_SRK2E_ARATH CAMK 3.1e-77 265.4 1 256 256 159 160 161 163 165 50 65 69 137 139 138 140 199 186 181 180 179 178 177 176 175 95 Serine/threonine-protein kinase SRK2E
CAMK SRK2E SRK2E_ARATH 3UC4A Q940H6 12 318 362.0 No_ligand No_ligand Inactive DFGinter 10.419 8.803 None DFGAsp-rot-out -97.83, 106.12 -111.34, 79.34 314.8, 47.7 -172.98, -178.43 64.01, 91.63 172.73, 93.4 out-out out 10.993 Saltbr-out 9.773 HRD-out -94.45, -144.27 57.85, 64.78 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nioo APE10-dihe-na -55.05, 149.11 APE9-dihe-na -108.74, -144.63 APE8-dihe-in -66.94, 137.61 APE8-rot-in 311.07 APE67-dihe-in -51.84, -39.21 -67.86, -12.89 APE12-dist-none 999.0 APE11-dist-in 13.889 APE10-dist-out 16.606 APE9-dist-out 15.591 D59A,E60A None None XRAY 2.3 0.223 0.246 A 362 295 12 0 0 12 [[21, 277]] 1.0 3uc4 Arabidopsis thaliana CAMK_SRK2E_ARATH CAMK 5.3e-79 271.2 1 256 256 159 160 161 163 165 50 65 69 137 139 138 140 199 186 181 180 179 178 177 176 175 95 Serine/threonine-protein kinase SRK2E
CAMK SRK2E SRK2E_ARATH 3UC4B Q940H6 12 317 362.0 No_ligand No_ligand Inactive DFGinter 9.763 9.844 None DFGAsp-rot-in -87.79, 109.76 -113.77, 77.45 191.58, -61.38 -112.94, -178.18 314.75, 135.71 -167.77, 42.25 out-out out 10.656 Saltbr-out 11.458 HRD-out -49.56, 113.93 -99.19, 165.37 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -81.5, 146.08 APE9-dihe-na -145.54, 122.05 APE8-dihe-in -91.29, 141.51 APE8-rot-out 164.59 APE67-dihe-in -51.35, -36.1 -66.05, -10.11 APE12-dist-out 17.154 APE11-dist-out 14.536 APE10-dist-out 20.449 APE9-dist-out 15.513 D59A,E60A None None XRAY 2.3 0.223 0.246 B 362 277 11 0 0 11 [[21, 277]] 1.0 3uc4 Arabidopsis thaliana CAMK_SRK2E_ARATH CAMK 5.3e-79 271.2 1 256 256 159 160 161 163 165 50 65 69 137 139 138 140 199 186 181 180 179 178 177 176 175 95 Serine/threonine-protein kinase SRK2E
AGC GRK1 GRK1_BOVIN 3C4YB P28327 30 532 561.0 No_ligand No_ligand Inactive DFGinter 8.04 10.553 None DFGAsp-rot-in -138.64, 168.89 59.27, 104.12 204.97, 48.94 -125.95, 37.77 308.57, 133.4 -61.52, -52.16 in-out in 9.832 Saltbr-out 4.417 HRD-in -105.99, -36.37 67.54, -61.73 out-in-in SNCoii in-in ActLoopNT-in 3.206 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -178.33, 157.76 APE9-dihe-na 144.04, -133.41 APE8-dihe-in -135.26, 121.19 APE8-rot-in 303.52 APE67-dihe-inflip 122.3, -40.41 -49.79, 107.51 APE12-dist-in 11.426 APE11-dist-in 12.656 APE10-dist-in 7.632 APE9-dist-in 5.789 None None None XRAY 7.509 0.182 999.0 B 543 466 8 0 0 0 [[187, 452]] 1.0 3c4y Bos taurus AGC_GRK1_BOVIN AGC 3.2e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
OTHER PKNG Q8NM29_CORGL 7MXJA Q8NM29 62 358 751.0 MAP:60502 Type1 Inactive DFGinter 6.293 10.601 None DFGAsp-rot-in -111.55, -5.33 -97.65, 70.49 198.93, -1.99 -64.68, -29.22 283.51, 177.78 -64.44, -22.13 out-out out 15.695 Saltbr-out 15.021 HRD-in -87.66, -33.88 74.73, -35.65 out-in-out SNCoio in-out ActLoopNT-in 2.848 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -89.56, 75.8 APE9-dihe-na -90.07, -165.64 APE8-dihe-in -127.82, 123.34 APE8-rot-in 300.01 APE67-dihe-inflip 102.34, -29.53 -61.55, 136.0 APE12-dist-in 10.93 APE11-dist-out 7.83 APE10-dist-in 5.018 APE9-dist-in 3.78 None None None XRAY 1.92 0.2 0.225 A 305 285 5 0 0 0 [[104, 300]] 1.0 7mxj Corynebacterium glutamicum OTHER_PKNG_CORGL CAMK 7.6e-21 80.7 1 186 186 246 247 248 250 252 134 151 155 227 229 228 230 281 270 265 264 263 262 261 260 259 183 non-specific serine/threonine protein kinase
OTHER PKNG Q8NM29_CORGL 7MXKA Q8NM29 63 360 751.0 MAP:60502 Type1 Inactive DFGinter 6.194 10.434 None DFGAsp-rot-in -118.18, -5.51 -93.88, 67.71 200.06, -5.73 -62.41, -37.49 263.51, 7.21 -64.54, -17.14 out-out out 15.739 Saltbr-out 15.548 HRD-in -82.84, -35.3 75.7, -37.3 out-in-out SNCoio in-out ActLoopNT-in 2.839 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_ioii APE10-dihe-na -89.12, 60.2 APE9-dihe-na -82.13, -171.26 APE8-dihe-in -126.78, 123.26 APE8-rot-in 300.71 APE67-dihe-inflip 98.87, -23.41 -59.19, 137.58 APE12-dist-in 10.703 APE11-dist-out 7.784 APE10-dist-in 5.009 APE9-dist-in 3.749 None None None XRAY 1.99 0.21 0.237 A 305 292 6 0 0 0 [[104, 300]] 1.0 7mxk Corynebacterium glutamicum OTHER_PKNG_CORGL CAMK 7.6e-21 80.7 1 186 186 246 247 248 250 252 134 151 155 227 229 228 230 281 270 265 264 263 262 261 260 259 183 non-specific serine/threonine protein kinase
OTHER PKNG Q8NM29_CORGL 7MXBB Q8NM29 54 727 751.0 MAP:60901 Type1 Inactive DFGinter 5.205 10.811 None DFGAsp-rot-in -117.76, -14.76 -88.45, 66.45 201.61, -5.37 -66.91, -35.42 188.49, 46.74 -64.23, -11.33 out-out out 16.485 Saltbr-out 17.106 HRD-in -84.45, -36.61 76.45, -45.49 out-in-in SNCoii in-in ActLoopNT-in 2.774 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -79.04, -21.26 APE9-dihe-na -81.14, -177.06 APE8-dihe-in -127.04, 126.21 APE8-rot-in 302.13 APE67-dihe-inflip 106.12, -20.6 -59.76, 129.82 APE12-dist-in 11.141 APE11-dist-in 9.35 APE10-dist-in 4.109 APE9-dist-in 3.755 None None None XRAY 2.2 0.211 0.246 B 700 655 8 0 0 0 [[104, 300]] 1.0 7mxb Corynebacterium glutamicum OTHER_PKNG_CORGL CAMK 5e-20 78.5 1 186 186 246 247 248 250 252 134 151 155 227 229 228 230 281 270 265 264 263 262 261 260 259 183 non-specific serine/threonine protein kinase
TYR SRC SRC_CHICK 2QQ7B P00523 258 533 533.0 SR2:1345 Type1 Inactive DFGinter 9.517 7.614 None DFGAsp-rot-out -107.97, -176.31 -160.38, -10.12 75.27, -46.14 -153.22, -18.85 328.02, 74.39 140.07, -38.97 none-none none 999.0 Saltbr-none 999.0 HRD-in -84.14, -56.03 85.98, -16.08 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 53.57 APE8-rot-na 13.57 APE67-dihe-in -68.8, -27.47 -72.76, -15.15 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 T338M,S345C None None XRAY 2.38 0.217 0.266 B 286 244 32 0 0 17 [[267, 518]] 1.0 2qq7 Gallus gallus TYR_SRC_CHICK TYR 3.5e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
TYR SRC SRC_CHICK 3LOKB P00523 258 533 533.0 DJK:1345 Type1 Inactive DFGinter 8.998 7.343 None DFGAsp-rot-out -159.95, 165.79 -130.83, 138.21 36.19, -34.37 -129.88, -38.43 343.22, 92.96 171.11, -62.33 none-none none 999.0 Saltbr-none 999.0 HRD-in -82.23, -48.63 85.47, -21.61 none-none-none SNCnnn none-none ActLoopNT-none 999.0 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, -14.67 APE8-rot-na 348.92 APE67-dihe-in -76.3, -19.85 -81.25, -4.67 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 T338M,S345C None None XRAY 2.48 0.225 0.286 B 286 242 34 0 0 17 [[267, 518]] 1.0 3lok Gallus gallus TYR_SRC_CHICK TYR 3.5e-94 320.9 1 260 260 403 404 405 407 409 295 310 314 383 385 384 386 444 432 427 426 425 424 423 422 421 339 Proto-oncogene tyrosine-protein kinase Src
CAMK AURKA AURKA_MOUSE 3DAJA P97477 118 379 395.0 FXG:60001 Type1 Inactive DFGinter 9.56 7.402 None DFGAsp-rot-out -134.29, 76.42 -147.47, -168.09 58.09, 23.4 -117.97, 39.39 298.8, 92.41 -105.61, 25.6 out-out out 12.111 Saltbr-out 11.144 HRD-out -117.62, 145.96 -85.7, -149.13 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 139.61 APE8-rot-in 314.8 APE67-dihe-in -53.82, -22.73 -58.61, -35.04 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 N164G,K218R,T278D,M280L None None XRAY 2.0 0.253 0.284 A 272 245 17 0 0 13 [[124, 374]] 1.0 3daj Mus musculus CAMK_AURKA_MOUSE CAMK 6.2e-80 274.2 1 256 256 264 265 266 268 270 153 172 176 244 246 245 247 302 290 285 284 283 282 281 280 279 202 Aurora kinase A
TYR ABL1 ABL1_MOUSE 3DK7A P00520 233 502 1123.0 SX7:1 Type1 Inactive DFGinter 9.521 4.47 None DFGAsp-rot-out -65.94, 133.62 -136.37, 26.36 53.27, 1.48 -59.29, -46.94 277.65, 138.09 -96.98, 21.57 in-in in 7.766 Saltbr-in 2.793 HRD-in -90.33, -58.06 79.79, -1.99 in-out-in SNCioi out-in ActLoopNT-out 5.675 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -107.5, 130.75 APE9-dihe-in -114.11, 153.09 APE8-dihe-in -69.74, 90.62 APE8-rot-na 25.02 APE67-dihe-in -72.01, -11.59 -51.31, -42.54 APE12-dist-na 20.579 APE11-dist-na 15.929 APE10-dist-na 18.225 APE9-dist-na 7.447 T315I,L445P PTR393 PTR393 XRAY 2.01 0.216 0.242 A 277 266 4 0 0 0 [[242, 495]] 1.0 3dk7 Mus musculus TYR_ABL1_MOUSE TYR 2.7e-100 341.0 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 3DK6A P00520 233 502 1123.0 SX7:1 Type1 Inactive DFGinter 9.835 8.306 None DFGAsp-rot-out -61.57, 128.5 -127.52, 27.29 57.49, -6.44 -83.26, -21.75 331.68, 119.16 -112.49, 27.73 in-in in 7.974 Saltbr-in 2.893 HRD-in -91.42, -55.08 73.35, 1.27 in-out-in SNCioi out-in ActLoopNT-out 5.66 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -110.77, 134.59 APE9-dihe-in -117.57, 154.09 APE8-dihe-in -69.69, 91.12 APE8-rot-na 24.6 APE67-dihe-in -73.26, -8.23 -48.64, -44.69 APE12-dist-na 20.525 APE11-dist-na 15.941 APE10-dist-na 18.171 APE9-dist-na 7.39 Y253F,L445P PTR393 PTR393 XRAY 2.02 0.216 0.246 A 293 263 7 0 0 0 [[242, 495]] 1.0 3dk6 Mus musculus TYR_ABL1_MOUSE TYR 3.3e-101 343.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 3DK6B P00520 234 505 1123.0 SX7:2 Type1 Inactive DFGinter 9.607 8.211 None DFGAsp-rot-out -63.13, 129.74 -127.1, 39.65 56.63, -8.57 -91.94, -7.89 322.45, 123.44 -137.52, 35.5 in-none in 8.477 Saltbr-none 999.0 HRD-in -90.89, -55.29 76.04, -7.16 none-out-in SNCnoi out-in ActLoopNT-out 5.58 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -104.73, 139.41 APE9-dihe-in -127.03, 148.23 APE8-dihe-in -65.18, 97.87 APE8-rot-na 342.63 APE67-dihe-in -74.45, -10.42 -49.61, -43.27 APE12-dist-na 18.841 APE11-dist-na 14.184 APE10-dist-na 17.301 APE9-dist-na 6.943 Y253F,L445P PTR393 PTR393 XRAY 2.02 0.216 0.246 B 293 260 12 0 0 0 [[242, 495]] 1.0 3dk6 Mus musculus TYR_ABL1_MOUSE TYR 3.3e-101 343.9 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 3DK3A P00520 233 502 1123.0 SX7:1 Type1 Inactive DFGinter 9.037 4.534 None DFGAsp-rot-out -66.29, 133.89 -136.12, 20.26 55.83, -5.52 -58.29, -43.12 280.16, 137.15 -98.94, 20.71 in-in in 7.628 Saltbr-in 2.858 HRD-in -87.93, -54.51 76.79, -4.02 in-out-in SNCioi out-in ActLoopNT-out 5.681 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -104.14, 131.04 APE9-dihe-in -114.33, 156.79 APE8-dihe-in -71.32, 89.5 APE8-rot-na 25.37 APE67-dihe-in -70.0, -11.6 -49.65, -44.27 APE12-dist-na 20.741 APE11-dist-na 16.009 APE10-dist-na 18.29 APE9-dist-na 7.277 Y393F,L445P None None XRAY 2.02 0.213 0.248 A 293 266 4 0 0 0 [[242, 495]] 1.0 3dk3 Mus musculus TYR_ABL1_MOUSE TYR 1.4e-99 338.7 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR ABL1 ABL1_MOUSE 3DK3B P00520 233 505 1123.0 SX7:2 Type1 Inactive DFGinter 8.654 4.762 None DFGAsp-rot-out -66.35, 137.23 -141.11, 32.97 57.12, -3.35 -68.57, -40.89 274.02, 151.63 -104.05, 31.43 in-in in 7.726 Saltbr-in 2.728 HRD-in -97.18, -55.69 76.9, -3.17 in-out-in SNCioi out-in ActLoopNT-out 5.554 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -102.31, 136.08 APE9-dihe-in -118.61, 148.91 APE8-dihe-in -68.85, 95.72 APE8-rot-na 24.23 APE67-dihe-in -70.92, -12.54 -48.57, -45.29 APE12-dist-na 19.212 APE11-dist-na 14.55 APE10-dist-na 17.621 APE9-dist-na 7.002 Y393F,L445P None None XRAY 2.02 0.213 0.248 B 293 269 4 0 0 0 [[242, 495]] 1.0 3dk3 Mus musculus TYR_ABL1_MOUSE TYR 1.4e-99 338.7 1 260 260 380 381 382 384 386 271 286 290 360 362 361 363 421 409 404 403 402 401 400 399 398 316 Tyrosine-protein kinase ABL1
TYR BTK BTK_MOUSE 8S9FA P35991 392 659 659.0 1N1:801 Type1 Inactive DFGinter 9.738 8.477 BABtrans DFGAsp-rot-out -103.75, 162.9 -98.62, -12.56 301.91, 16.91 -74.46, 134.73 203.6, 82.29 75.53, 30.46 out-out out 11.325 Saltbr-out 8.457 HRD-out -78.16, 120.76 -71.26, -27.71 out-out-none SNCoon out-none ActLoopNT-out 5.464 ActLoopCT-none TYR APEdihe_nnnai APEdist_aaaa APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 999.0 APE8-dihe-none 999.0, 89.3 APE8-rot-na 354.27 APE67-dihe-in -88.28, 1.83 -66.03, -37.53 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-na 999.0 L390G,Y551E,Y617P None None XRAY 2.6 0.244 0.284 A 279 254 14 0 0 14 [[402, 653]] 1.0 8s9f Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR BTK BTK_MOUSE 8S9FB P35991 392 659 659.0 1N1:801 Type1 Inactive DFGinter 9.509 8.472 BABtrans DFGAsp-rot-out -108.61, 149.63 -109.15, 7.92 46.16, -6.54 -82.22, 131.91 185.43, 98.64 78.7, 27.48 out-out out 11.019 Saltbr-out 10.329 HRD-out -91.58, 112.75 -69.14, -29.29 out-out-none SNCoon out-none ActLoopNT-out 5.681 ActLoopCT-none TYR APEdihe_niiai APEdist_aaaa APE10-dihe-none 999.0, 166.92 APE9-dihe-in -91.32, 115.75 APE8-dihe-in -71.7, 107.6 APE8-rot-na 25.58 APE67-dihe-in -83.25, -12.58 -54.13, -30.99 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 16.149 APE9-dist-na 18.604 L390G,Y551E,Y617P None None XRAY 2.6 0.244 0.284 B 279 255 13 0 0 12 [[402, 653]] 1.0 8s9f Mus musculus TYR_BTK_MOUSE TYR 1.3e-92 315.7 1 258 258 538 539 540 542 544 430 445 449 518 520 519 521 579 567 562 561 560 559 558 557 556 475 Tyrosine-protein kinase BTK
TYR MUSK MUSK_RAT 1LUFA Q62838 560 860 868.0 No_ligand No_ligand Inactive DFGinter 10.747 6.618 None DFGAsp-rot-in -156.55, -169.71 -170.83, 84.62 196.97, -6.9 -80.52, -3.72 280.77, 72.0 68.08, 27.29 in-in in 8.975 Saltbr-in 3.432 HRD-in -65.48, -48.59 74.12, -6.34 in-out-in SNCioi out-in ActLoopNT-out 15.566 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaaa APE10-dihe-in -55.03, 128.61 APE9-dihe-in -122.59, 147.16 APE8-dihe-in -78.26, 60.9 APE8-rot-na 36.06 APE67-dihe-in -61.04, -10.56 -37.4, -50.92 APE12-dist-na 999.0 APE11-dist-na 15.136 APE10-dist-na 11.63 APE9-dist-na 7.438 None None None XRAY 2.05 0.231 0.246 A 343 275 26 0 0 4 [[574, 857]] 1.0 1luf Rattus norvegicus TYR_MUSK_RAT TYR 2e-96 328.3 1 260 260 741 742 743 745 747 608 625 629 721 723 722 724 783 771 766 765 764 763 762 761 760 655 Muscle, skeletal receptor tyrosine protein kinase
CAMK SNF1 SNF1_YEAST 3MN3A P06782 50 320 633.0 No_ligand No_ligand Inactive DFGinter 7.447 8.274 None DFGAsp-rot-in -80.18, 112.84 -124.36, 94.11 182.7, -18.24 -159.22, 145.62 193.28, 71.33 -146.65, 68.27 out-out out 10.903 Saltbr-out 11.872 HRD-out -63.7, 131.62 -118.95, 125.24 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oioo APE10-dihe-na -138.22, 172.63 APE9-dihe-na -65.35, 169.45 APE8-dihe-in -66.59, 127.25 APE8-rot-out 173.28 APE67-dihe-in -71.29, -19.51 -53.41, -27.07 APE12-dist-out 14.54 APE11-dist-in 11.88 APE10-dist-out 14.64 APE9-dist-out 8.841 None None None XRAY 2.38 0.231 0.246 A 271 252 19 0 0 7 [[55, 306]] 1.0 3mn3 Saccharomyces cerevisiae CAMK_SNF1_YEAST CAMK 6.8e-92 313.4 1 256 256 194 195 196 198 200 84 103 107 174 176 175 177 234 221 216 215 214 213 212 211 210 133 Carbon catabolite-derepressing protein kinase
CAMK SAPK10 A0A238LNS4_9POAL 5WAXA A0A238LNS4 13 320 362.0 No_ligand No_ligand Inactive DFGinter 9.433 8.754 None DFGAsp-rot-in -95.22, 76.51 -86.03, 66.52 184.93, 15.07 -159.46, 159.08 66.57, 74.23 -158.49, 121.19 out-out out 10.455 Saltbr-out 10.338 HRD-out -62.64, 138.2 -125.04, 143.21 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanoi APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 133.57 APE8-rot-out 178.64 APE67-dihe-in -48.8, -32.62 -63.74, -8.72 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.2 0.237 A 310 279 15 0 0 15 [[23, 279]] 1.0 5wax Saccharum officinarum CAMK_SAPK10_9POAL CAMK 1.9e-80 276.0 1 256 256 161 162 163 165 167 52 67 71 139 141 140 142 201 188 183 182 181 180 179 178 177 97 non-specific serine/threonine protein kinase
CAMK SAPK10 A0A238LNS4_9POAL 5WAXB A0A238LNS4 14 320 362.0 No_ligand No_ligand Inactive DFGinter 9.72 8.965 None DFGAsp-rot-none -90.88, 81.91 -92.01, 76.84 999.0, 999.0 -157.22, 160.01 61.41, 82.21 -156.89, 118.97 out-none out 10.574 Saltbr-none 999.0 HRD-out 57.72, -125.16 -51.83, -34.36 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nooo APE10-dihe-na -103.01, 91.32 APE9-dihe-na -96.06, 9.42 APE8-dihe-in -62.15, 131.43 APE8-rot-out 180.15 APE67-dihe-in -47.58, -34.71 -64.6, -7.6 APE12-dist-none 999.0 APE11-dist-out 17.654 APE10-dist-out 19.336 APE9-dist-out 14.094 None None None XRAY 2.0 0.2 0.237 B 310 274 18 0 0 12 [[23, 279]] 1.0 5wax Saccharum officinarum CAMK_SAPK10_9POAL CAMK 1.9e-80 276.0 1 256 256 161 162 163 165 167 52 67 71 139 141 140 142 201 188 183 182 181 180 179 178 177 97 non-specific serine/threonine protein kinase
CAMK SSP2 SNF1_SCHPO 3H4JB O74536 27 351 576.0 No_ligand No_ligand Inactive DFGinter 6.889 9.762 None DFGAsp-rot-out -123.85, 118.75 -132.48, 74.37 291.58, -38.5 -128.19, 27.87 291.57, 83.53 49.54, 50.74 out-out out 12.81 Saltbr-out 8.137 HRD-out -72.18, 56.45 -117.36, 20.63 out-out-out SNCooo out-out ActLoopNT-out 16.557 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -46.91, 136.15 APE9-dihe-na 102.12, -9.85 APE8-dihe-in -108.02, 143.53 APE8-rot-out 178.23 APE67-dihe-in -75.68, -14.71 -63.53, -27.64 APE12-dist-in 10.431 APE11-dist-in 11.859 APE10-dist-out 16.139 APE9-dist-out 9.354 None None None XRAY 2.8 0.22 0.257 B 336 325 0 0 0 0 [[34, 285]] 1.0 3h4j Schizosaccharomyces pombe CAMK_SSP2_SCHPO CAMK 1.8e-90 309.0 1 256 256 173 174 175 177 179 63 82 86 153 155 154 156 213 200 195 194 193 192 191 190 189 112 SNF1-like protein kinase ssp2
AGC TB0348O8470 Q582V7_TRYB2 9Z8KB Q582V7 54 347 406.0 No_ligand No_ligand Inactive DFGinter 4.787 10.505 None DFGAsp-rot-out -71.68, 124.57 -107.67, -28.59 268.28, -9.83 -125.91, 34.63 312.76, 87.28 -93.76, -164.0 in-in in 8.873 Saltbr-in 2.956 HRD-in -66.47, -46.77 68.54, -6.62 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -89.62 APE8-dihe-out -52.69, -45.07 APE8-rot-out 190.44 APE67-dihe-in -78.75, -15.67 -59.7, -24.89 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.297 None None None XRAY 2.05 0.197 0.235 B 362 271 23 0 0 23 [[61, 326]] 1.0 9z8k Trypanosoma brucei brucei AGC_TB0348O8470_TRYB2 AGC 4e-77 264.9 1 259 259 203 204 205 207 209 90 109 113 183 185 184 186 252 240 235 234 233 232 231 230 229 139 Serine/threonine-protein kinase, putative