Ligand: ATP

Total number of chains: 173
Active chains: 68
Total number of genes: 31
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 112 64.7% 5LVOA
DFGin BLBplus 21 12.1% 3DKCA
DFGinter None 14 8.1% 9D5IA
DFGin None 12 6.9% 5I4NA
DFGin BLBtrans 6 3.5% 1HCKA
DFGin ABAminus 4 2.3% 7T4TA
None None 3 1.7% 4FG8B
DFGout None 1 0.6% 8FO9E

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC GRK5 GRK5_HUMAN 9CKRA P34947 25 542 590.0 ATP:603 ATPlike Active DFGin 6.1719 12.8672 BLAminus -123.04, 159.77 67.48, 80.75 -99.52, 5.04 278.7, 83.61 -52.63, -21.44 in-in in 8.5891 Saltbr-in 3.447 HRD-in -94.88, -52.49 68.7, 5.59 in-in-in SNCiii in-in ActLoopNT-in 2.9677 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.66, 167.59 APE9-dihe-na 129.66, -152.54 APE8-dihe-in -119.66, 138.17 APE8-rot-in 320.31 APE67-dihe-inflip 80.19, -6.12 -54.38, 134.58 APE12-dist-in 9.8722 APE11-dist-in 12.2584 APE10-dist-in 6.5289 APE9-dist-in 4.1807 D311N None None XRAY 2.8 0.239 0.286 A 598.0 501.0 0 27 27 0 [[186, 448]] 1.0 9ckr AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9CKSA P34947 25 542 590.0 ATP:603 ATPlike Active DFGin 6.0382 13.0612 BLAminus -123.04, 167.6 79.98, 56.79 -87.17, 17.84 285.5, 62.72 -70.38, -31.79 in-in in 9.2222 Saltbr-in 2.6724 HRD-in -92.29, -53.7 68.73, 3.48 in-in-in SNCiii in-in ActLoopNT-in 2.9627 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.24, 151.24 APE9-dihe-na 138.17, -158.29 APE8-dihe-in -117.35, 145.2 APE8-rot-in 310.61 APE67-dihe-inflip 85.98, -22.04 -53.6, 135.84 APE12-dist-in 10.6156 APE11-dist-in 12.4068 APE10-dist-in 6.5628 APE9-dist-in 4.2067 D311N None None XRAY 3.08 0.228 0.28 A 598.0 501.0 0 27 27 0 [[186, 448]] 1.0 9cks AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC PDPK1 PDPK1_HUMAN 1H1WA O15530 71 359 556.0 ATP:1373 ATPlike Inactive DFGin 6.6116 14.931 BLAminus -145.26, -169.97 71.92, 72.18 -105.82, -0.04 289.27, 102.08 -58.33, -31.92 in-in in 8.5808 Saltbr-in 2.7103 HRD-in -71.45, -48.32 74.08, -8.04 in-in-out SNCiio in-out ActLoopNT-in 2.8395 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -131.69, 112.94 APE9-dihe-na -63.98, -168.66 APE8-dihe-in -54.13, 124.0 APE8-rot-in 301.59 APE67-dihe-in -62.54, -19.03 -38.83, -50.46 APE12-dist-in 8.922 APE11-dist-out 5.528 APE10-dist-out 10.2978 APE9-dist-in 3.7994 None SEP241 SEP241 XRAY 2.0 0.196 0.223 A 289.0 285.0 4 30 26 4 [[82, 342]] 1.0 1h1w AGC_PDPK1_HUMAN AGC 9.8e-85 289.7 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 2BIYA O15530 72 359 556.0 ATP:1373 ATPlike Active DFGin 6.6186 15.0949 BLAminus -141.33, -175.84 82.91, 67.67 -104.99, 1.58 283.05, 104.18 -61.63, -33.06 in-in in 8.6731 Saltbr-in 2.5745 HRD-in -63.52, -52.73 78.44, -11.09 in-in-in SNCiii in-in ActLoopNT-in 2.8201 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -88.22, 130.12 APE9-dihe-na 106.71, 171.13 APE8-dihe-in -96.94, 126.07 APE8-rot-in 299.07 APE67-dihe-in -62.15, -19.51 -52.23, -44.36 APE12-dist-in 12.8679 APE11-dist-in 12.8691 APE10-dist-in 7.2677 APE9-dist-in 4.7446 S241A None None XRAY 1.95 0.186 0.23 A 310.0 288.0 0 30 30 0 [[82, 342]] 1.0 2biy AGC_PDPK1_HUMAN AGC 1.8e-84 288.8 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3HRCA O15530 76 359 556.0 ATP:1373 ATPlike Active DFGin 6.4861 14.8331 BLAminus -136.91, -178.17 71.81, 74.55 -104.54, 6.98 286.89, 102.51 -65.47, -24.41 in-in in 8.4211 Saltbr-in 3.1591 HRD-in -77.24, -54.93 76.93, -11.42 in-in-in SNCiii in-in ActLoopNT-in 2.87 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.25, 162.0 APE9-dihe-na 130.63, -171.63 APE8-dihe-in -125.01, 129.68 APE8-rot-in 292.48 APE67-dihe-in -58.92, -25.29 -45.32, -48.7 APE12-dist-in 7.4085 APE11-dist-in 10.582 APE10-dist-in 4.9259 APE9-dist-in 3.4793 Y288G,Q292A SEP241 SEP241 XRAY 1.91 0.182 0.207 A 311.0 280.0 4 30 26 4 [[82, 342]] 1.0 3hrc AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4RRVA O15530 76 359 556.0 ATP:60401 ATPlike Active DFGin 6.5481 14.9984 BLAminus -136.55, -175.99 74.63, 72.8 -106.52, 5.78 286.61, 100.18 -68.12, -17.88 in-in in 8.5198 Saltbr-in 2.956 HRD-in -71.77, -54.29 78.75, -11.73 in-in-in SNCiii in-in ActLoopNT-in 2.9375 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.13, 162.83 APE9-dihe-na 132.08, -169.67 APE8-dihe-in -127.24, 132.02 APE8-rot-in 298.33 APE67-dihe-in -59.21, -24.3 -51.83, -46.04 APE12-dist-in 7.2806 APE11-dist-in 10.5025 APE10-dist-in 4.943 APE9-dist-in 3.5694 Y288G,Q292A SEP241 SEP241 XRAY 1.412 0.135 0.163 A 311.0 284.0 0 30 30 0 [[82, 342]] 1.0 4rrv AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5ACKA O15530 73 359 556.0 ATP:500 ATPlike Active DFGin 6.6153 14.8606 BLAminus -135.34, 179.84 72.22, 79.01 -106.01, 4.14 287.93, 97.64 -67.02, -18.73 in-in in 8.4184 Saltbr-in 2.5825 HRD-in -74.68, -53.67 78.01, -12.73 in-in-in SNCiii in-in ActLoopNT-in 2.9064 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.4, 162.51 APE9-dihe-na 136.44, -168.07 APE8-dihe-in -132.35, 133.52 APE8-rot-in 296.36 APE67-dihe-in -62.96, -23.95 -54.34, -43.19 APE12-dist-in 7.3257 APE11-dist-in 10.5222 APE10-dist-in 4.9779 APE9-dist-in 3.5575 Y288G,Q292A SEP241 SEP241 XRAY 1.24 0.143 0.166 A 311.0 287.0 0 30 30 0 [[82, 342]] 1.0 5ack AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVPA O15530 75 359 556.0 ATP:500 ATPlike Active DFGin 6.3028 14.9979 BLAminus -144.92, -168.82 66.06, 77.78 -108.23, 11.17 281.99, 93.22 -63.04, -32.41 in-in in 9.539 Saltbr-in 3.1581 HRD-in -77.47, -51.83 79.92, -12.48 in-in-in SNCiii in-in ActLoopNT-in 2.8481 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.64, 166.02 APE9-dihe-na 141.61, 177.5 APE8-dihe-in -123.02, 134.29 APE8-rot-in 296.02 APE67-dihe-in -68.65, -16.53 -46.89, -50.92 APE12-dist-in 7.9068 APE11-dist-in 10.6706 APE10-dist-in 5.166 APE9-dist-in 3.7049 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 A 311.0 276.0 9 30 21 9 [[82, 342]] 1.0 5lvp AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVPB O15530 74 359 556.0 ATP:401 ATPlike Active DFGin 6.3283 14.5498 BLAminus -137.23, -179.71 80.14, 74.16 -105.47, 15.38 295.0, 84.83 -59.91, -31.47 in-in in 9.2741 Saltbr-in 3.3024 HRD-in -80.68, -44.41 73.96, -16.23 in-in-in SNCiii in-in ActLoopNT-in 2.7443 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.8, 152.43 APE9-dihe-na 134.43, -173.75 APE8-dihe-in -120.09, 128.28 APE8-rot-in 302.93 APE67-dihe-in -67.56, -25.72 -44.99, -47.55 APE12-dist-in 7.8719 APE11-dist-in 11.0112 APE10-dist-in 5.3751 APE9-dist-in 3.7868 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 B 311.0 277.0 9 30 21 9 [[82, 342]] 1.0 5lvp AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVPC O15530 75 359 556.0 ATP:401 ATPlike Active DFGin 6.3906 14.6076 BLAminus -132.15, -176.81 71.98, 84.02 -116.53, 7.62 291.47, 90.46 -60.24, -24.5 in-in in 9.3044 Saltbr-in 3.0866 HRD-in -75.92, -52.06 78.45, -5.49 in-in-in SNCiii in-in ActLoopNT-in 2.8228 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.81, 168.64 APE9-dihe-na 131.92, -176.79 APE8-dihe-in -126.79, 133.21 APE8-rot-in 299.13 APE67-dihe-in -67.64, -15.8 -51.62, -50.49 APE12-dist-in 7.6523 APE11-dist-in 10.8632 APE10-dist-in 5.1235 APE9-dist-in 3.6447 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 C 311.0 276.0 9 30 21 9 [[82, 342]] 1.0 5lvp AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVPD O15530 74 359 556.0 ATP:500 ATPlike Active DFGin 6.3336 14.4328 BLAminus -146.99, -174.22 74.22, 81.56 -113.84, 4.02 287.97, 93.59 -56.11, -25.73 in-in in 9.3044 Saltbr-in 3.2517 HRD-in -82.38, -50.18 78.4, -12.51 in-in-in SNCiii in-in ActLoopNT-in 2.8357 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.65, 165.17 APE9-dihe-na 129.1, -166.82 APE8-dihe-in -132.84, 129.79 APE8-rot-in 300.06 APE67-dihe-in -65.46, -17.03 -48.9, -48.47 APE12-dist-in 8.2282 APE11-dist-in 10.8909 APE10-dist-in 5.3485 APE9-dist-in 3.6459 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 D 311.0 277.0 9 30 21 9 [[82, 342]] 1.0 5lvp AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4CT2A O15530 75 359 556.0 ATP:500 ATPlike Active DFGin 6.5509 14.8668 BLAminus -136.23, -174.98 70.54, 70.07 -102.02, 6.41 290.69, 95.78 -63.73, -21.59 in-in in 8.2523 Saltbr-in 2.6427 HRD-in -73.2, -54.84 77.37, -9.78 in-in-in SNCiii in-in ActLoopNT-in 2.9649 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.02, 163.59 APE9-dihe-na 137.39, -170.05 APE8-dihe-in -132.12, 131.72 APE8-rot-in 295.26 APE67-dihe-in -63.06, -17.27 -51.84, -45.87 APE12-dist-in 7.1628 APE11-dist-in 10.5242 APE10-dist-in 4.9787 APE9-dist-in 3.5273 L113V,I118V,I119H,V124I,T128Q,R131K,T148C,F157L,Y288G,Q292A SEP241 SEP241 XRAY 1.25 0.194 0.226 A 311.0 280.0 5 30 30 0 [[82, 342]] 1.0 4ct2 AGC_PDPK1_HUMAN AGC 9.5e-84 286.4 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5MRDA O15530 76 359 556.0 ATP:405 ATPlike Active DFGin 6.4288 14.7004 BLAminus -133.69, -177.11 74.21, 73.9 -105.88, 9.0 289.39, 99.64 -68.32, -19.62 in-in in 8.3463 Saltbr-in 2.6673 HRD-in -74.32, -53.19 77.26, -10.58 in-in-in SNCiii in-in ActLoopNT-in 2.9416 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.86, 160.68 APE9-dihe-na 136.11, -166.87 APE8-dihe-in -131.1, 132.63 APE8-rot-in 296.36 APE67-dihe-in -62.36, -23.28 -53.02, -44.84 APE12-dist-in 7.3524 APE11-dist-in 10.4975 APE10-dist-in 4.9095 APE9-dist-in 3.5424 K76S,L113V,I118V,I119N,V124I,T128Q,R131K,T148C SEP241 SEP241 XRAY 1.41 0.142 0.174 A 310.0 284.0 0 30 30 0 [[82, 342]] 1.0 5mrd AGC_PDPK1_HUMAN AGC 1.7e-83 285.6 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3HRFA O15530 75 359 556.0 ATP:1373,P47:1374 ATPlike,Allosteric Active DFGin 6.5137 14.7842 BLAminus -133.77, -176.11 75.25, 77.12 -110.83, 6.58 287.55, 100.98 -63.85, -22.79 in-in in 8.3869 Saltbr-in 2.7006 HRD-in -73.67, -53.98 76.59, -10.73 in-in-in SNCiii in-in ActLoopNT-in 2.9232 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.42, 166.15 APE9-dihe-na 124.75, -165.6 APE8-dihe-in -127.97, 128.5 APE8-rot-in 295.31 APE67-dihe-in -62.28, -24.12 -44.34, -47.42 APE12-dist-in 7.3513 APE11-dist-in 10.5457 APE10-dist-in 4.8669 APE9-dist-in 3.4806 Y288G,Q292A SEP241 SEP241 XRAY 1.9 0.165 0.177 A 311.0 285.0 0 30 30 0 [[82, 342]] 1.0 3hrf AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4A06A O15530 75 359 556.0 ATP:500,A06:600 ATPlike,Allosteric Active DFGin 6.5121 14.757 BLAminus -135.73, -177.17 74.25, 74.67 -110.25, 11.82 284.97, 101.73 -68.23, -22.46 in-in in 8.3192 Saltbr-in 2.8636 HRD-in -73.73, -51.84 74.62, -10.07 in-in-in SNCiii in-in ActLoopNT-in 2.9204 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.65, 165.25 APE9-dihe-na 128.95, -173.35 APE8-dihe-in -120.15, 131.51 APE8-rot-in 299.31 APE67-dihe-in -59.46, -27.29 -45.75, -47.91 APE12-dist-in 7.336 APE11-dist-in 10.4473 APE10-dist-in 4.8734 APE9-dist-in 3.5088 Y288G,Q292A SEP241 SEP241 XRAY 2.0 0.161 0.198 A 311.0 285.0 0 30 30 0 [[82, 342]] 1.0 4a06 AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4AW0A O15530 75 359 556.0 ATP:500,MJF:600 ATPlike,Allosteric Active DFGin 6.5313 14.9926 BLAminus -134.84, 177.25 78.73, 76.19 -106.3, 8.53 283.51, 97.11 -69.63, -19.36 in-in in 8.5954 Saltbr-in 3.0091 HRD-in -83.05, -53.03 79.45, -12.94 in-in-in SNCiii in-in ActLoopNT-in 2.9336 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.69, 159.04 APE9-dihe-na 139.48, -167.8 APE8-dihe-in -131.87, 132.42 APE8-rot-in 295.45 APE67-dihe-in -61.29, -25.28 -54.74, -42.17 APE12-dist-in 7.5089 APE11-dist-in 10.6011 APE10-dist-in 5.0264 APE9-dist-in 3.5797 Y288G,Q292A SEP241 SEP241,CME260 XRAY 1.43 0.171 0.188 A 311.0 285.0 0 30 30 0 [[82, 342]] 1.0 4aw0 AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4AW1A O15530 66 359 556.0 ATP:1360,21O:1361 ATPlike,Allosteric Active DFGin 6.325 14.155 BLAminus -137.24, -178.23 68.96, 84.69 -105.37, 17.06 286.01, 86.79 -62.77, -26.7 in-in in 8.5758 Saltbr-in 2.8639 HRD-in -81.18, -54.06 78.32, -13.29 in-in-in SNCiii in-in ActLoopNT-in 2.8487 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.98, 160.2 APE9-dihe-na 130.22, -162.57 APE8-dihe-in -126.98, 128.72 APE8-rot-in 295.96 APE67-dihe-in -57.45, -24.35 -48.01, -47.7 APE12-dist-in 7.6532 APE11-dist-in 10.8523 APE10-dist-in 5.0751 APE9-dist-in 3.5856 Y288G,Q292A SEP241 SEP241 XRAY 1.68 0.165 0.186 A 311.0 287.0 5 30 25 5 [[82, 342]] 1.0 4aw1 AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4RQKA O15530 74 359 556.0 ATP:403,R1S:404 ATPlike,Allosteric Active DFGin 6.4608 14.7857 BLAminus -139.06, -177.03 75.27, 72.83 -105.25, 7.36 287.3, 98.33 -64.7, -21.38 in-in in 8.4643 Saltbr-in 2.9412 HRD-in -73.98, -52.31 74.79, -9.31 in-in-in SNCiii in-in ActLoopNT-in 2.8799 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.64, 164.69 APE9-dihe-na 126.87, -171.23 APE8-dihe-in -124.75, 130.48 APE8-rot-in 298.57 APE67-dihe-in -59.79, -23.66 -48.31, -47.88 APE12-dist-in 7.2437 APE11-dist-in 10.4657 APE10-dist-in 4.9176 APE9-dist-in 3.5437 Y288G,Q292A SEP241 SEP241 XRAY 1.55 0.133 0.167 A 311.0 286.0 0 30 30 0 [[82, 342]] 1.0 4rqk AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4RQVA O15530 71 359 556.0 ATP:405,R2S:406 ATPlike,Allosteric Active DFGin 6.4916 14.9536 BLAminus -139.41, -174.88 74.87, 69.78 -102.0, 7.85 285.85, 94.73 -65.11, -21.56 in-in in 8.2557 Saltbr-in 2.7717 HRD-in -72.94, -52.57 74.87, -10.5 in-in-in SNCiii in-in ActLoopNT-in 2.9156 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.07, 164.19 APE9-dihe-na 130.69, -171.7 APE8-dihe-in -126.67, 130.74 APE8-rot-in 297.63 APE67-dihe-in -61.47, -23.77 -49.17, -46.26 APE12-dist-in 7.2532 APE11-dist-in 10.4876 APE10-dist-in 4.9687 APE9-dist-in 3.5133 Y288G,Q292A SEP241 SEP241 XRAY 1.502 0.133 0.166 A 311.0 289.0 0 30 30 0 [[82, 342]] 1.0 4rqv AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVOA O15530 73 359 556.0 ATP:401,78W:402 ATPlike,Allosteric Active DFGin 6.581 15.0047 BLAminus -134.78, 179.9 79.12, 70.17 -103.55, 0.25 286.72, 100.66 -64.63, -19.63 in-in in 8.5884 Saltbr-in 2.6313 HRD-in -71.89, -54.41 77.65, -9.82 in-in-in SNCiii in-in ActLoopNT-in 2.9194 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.78, 162.52 APE9-dihe-na 134.75, -167.11 APE8-dihe-in -130.46, 134.12 APE8-rot-in 296.12 APE67-dihe-in -62.26, -22.94 -53.92, -45.37 APE12-dist-in 7.4502 APE11-dist-in 10.5584 APE10-dist-in 4.9836 APE9-dist-in 3.5527 Y288G,Q292A SEP241 SEP241 XRAY 1.09 0.136 0.157 A 311.0 287.0 0 30 30 0 [[82, 342]] 1.0 5lvo AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4CT1A O15530 76 359 556.0 ATP:500,31S:600 ATPlike,Allosteric None DFGin 6.6022 14.9785 BLAminus -141.71, -172.51 72.43, 72.08 -107.06, 8.07 284.9, 97.13 -62.67, -20.12 in-none in 8.1463 Saltbr-none 999.0 HRD-in -74.62, -54.47 79.43, -8.97 none-in-in SNCnii in-in ActLoopNT-in 2.9992 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.29, 160.89 APE9-dihe-na 137.85, -171.95 APE8-dihe-in -126.26, 129.35 APE8-rot-in 296.2 APE67-dihe-in -61.08, -24.26 -47.64, -46.5 APE12-dist-in 7.3566 APE11-dist-in 10.4885 APE10-dist-in 5.0182 APE9-dist-in 3.4798 L113V,I118V,I119H,V124I,T128Q,R131K,T148C,F157L,Y288G,Q292A SEP241 SEP241 XRAY 1.85 0.172 0.215 A 311.0 284.0 0 30 30 0 [[82, 342]] 1.0 4ct1 AGC_PDPK1_HUMAN AGC 9.5e-84 286.4 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4XX9A O15530 71 359 556.0 ATP:401,RF4:402,RF4:403 ATPlike,Allosteric,Allosteric Active DFGin 6.5134 14.9881 BLAminus -138.47, -176.21 74.83, 73.76 -104.66, 7.86 282.59, 98.49 -68.99, -20.43 in-in in 8.4422 Saltbr-in 2.9225 HRD-in -73.71, -50.51 73.32, -9.3 in-in-in SNCiii in-in ActLoopNT-in 2.8949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.41, 162.37 APE9-dihe-na 129.79, -167.49 APE8-dihe-in -129.09, 132.1 APE8-rot-in 295.95 APE67-dihe-in -59.66, -23.23 -49.94, -47.34 APE12-dist-in 7.3717 APE11-dist-in 10.5754 APE10-dist-in 4.9467 APE9-dist-in 3.5452 Y288G,Q292A SEP241 SEP241 XRAY 1.4 0.13 0.165 A 310.0 289.0 0 30 30 0 [[82, 342]] 1.0 4xx9 AGC_PDPK1_HUMAN AGC 6.8e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4A07A O15530 75 359 556.0 ATP:500,AZ7:600,AZ7:700 ATPlike,Allosteric,Allosteric Active DFGin 6.6546 14.7523 BLAminus -135.35, -178.9 76.01, 72.4 -108.94, 8.63 286.31, 98.68 -64.37, -21.88 in-in in 8.6213 Saltbr-in 2.919 HRD-in -76.19, -54.82 80.07, -12.14 in-in-in SNCiii in-in ActLoopNT-in 2.9107 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.16, 162.52 APE9-dihe-na 132.15, -164.48 APE8-dihe-in -133.89, 130.56 APE8-rot-in 295.87 APE67-dihe-in -62.13, -24.83 -47.31, -46.9 APE12-dist-in 7.3216 APE11-dist-in 10.4272 APE10-dist-in 4.9977 APE9-dist-in 3.5816 Y288G,Q292A SEP241 SEP241,CSS260 XRAY 1.85 0.161 0.2 A 311.0 285.0 0 30 30 0 [[82, 342]] 1.0 4a07 AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PRKACA KAPCA_HUMAN 4WB8A P17612 16 351 351.0 ATP:60401 ATPlike Active DFGin 5.6838 14.4142 BLAminus -121.45, -177.2 62.67, 77.75 -91.98, 24.58 268.87, 53.09 -58.34, -31.51 in-in in 8.9131 Saltbr-in 2.7592 HRD-in -95.2, -52.32 70.44, 11.38 in-in-in SNCiii in-in ActLoopNT-in 2.9124 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.85, 164.58 APE9-dihe-na 131.46, -156.38 APE8-dihe-in -129.55, 139.43 APE8-rot-in 297.11 APE67-dihe-in -60.54, -22.69 -52.03, -49.04 APE12-dist-in 8.0978 APE11-dist-in 11.3919 APE10-dist-in 5.8266 APE9-dist-in 3.4975 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.55 0.164 0.184 A 337.0 336.0 0 25 25 0 [[44, 298]] 1.0 4wb8 AGC_PRKACA_HUMAN AGC 4e-95 323.8 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB5A P17612 14 351 351.0 ATP:60401 ATPlike Active DFGin 5.5996 14.452 BLAminus -123.05, 176.84 68.94, 80.02 -91.46, 24.86 270.2, 52.92 -60.74, -31.43 in-in in 9.0296 Saltbr-in 2.7148 HRD-in -92.12, -52.84 69.8, 13.37 in-in-in SNCiii in-in ActLoopNT-in 2.9178 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.48, 163.75 APE9-dihe-na 132.31, -149.49 APE8-dihe-in -132.05, 134.14 APE8-rot-in 301.14 APE67-dihe-in -60.1, -21.12 -48.44, -50.23 APE12-dist-in 8.0121 APE11-dist-in 11.4001 APE10-dist-in 5.799 APE9-dist-in 3.5673 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.641 0.165 0.196 A 350.0 338.0 0 25 25 0 [[44, 298]] 1.0 4wb5 AGC_PRKACA_HUMAN AGC 4.5e-95 323.7 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6NO7E P17612 13 351 351.0 ATP:60403 ATPlike Inactive DFGin 6.9335 14.1655 BLAminus -118.71, 175.9 64.55, 75.01 -86.85, 19.7 273.68, 51.02 -43.49, -41.12 in-out in 9.4189 Saltbr-out 5.4559 HRD-in -91.66, -53.62 73.72, 11.47 out-in-in SNCoii in-in ActLoopNT-in 3.1639 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.9, 150.23 APE9-dihe-na 149.21, -142.3 APE8-dihe-in -132.1, 131.95 APE8-rot-in 297.19 APE67-dihe-in -64.62, -25.64 -37.25, -53.79 APE12-dist-in 8.0557 APE11-dist-in 10.9843 APE10-dist-in 5.7482 APE9-dist-in 3.2156 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.55 0.259 0.269 E 350.0 339.0 0 25 25 0 [[44, 298]] 1.0 6no7 AGC_PRKACA_HUMAN AGC 4.5e-95 323.7 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6NO7G P17612 15 351 351.0 ATP:60403 ATPlike Inactive DFGin 6.0359 14.0844 BLAminus -118.68, 176.55 65.34, 76.32 -85.78, 18.75 273.72, 51.07 -44.34, -41.82 in-out in 9.7125 Saltbr-out 5.2149 HRD-in -91.95, -53.38 74.11, 11.57 out-in-in SNCoii in-in ActLoopNT-in 3.3017 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.42, 149.81 APE9-dihe-na 148.91, -142.4 APE8-dihe-in -132.18, 131.68 APE8-rot-in 297.12 APE67-dihe-in -64.98, -25.0 -37.42, -54.32 APE12-dist-in 7.6679 APE11-dist-in 10.658 APE10-dist-in 5.5534 APE9-dist-in 3.4096 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.55 0.259 0.269 G 350.0 337.0 0 25 25 0 [[44, 298]] 1.0 6no7 AGC_PRKACA_HUMAN AGC 4.5e-95 323.7 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB7A P17612 2 351 351.0 ATP:60501 ATPlike Active DFGin 5.4448 14.6485 BLAminus -119.06, -174.39 59.4, 77.28 -89.09, 26.42 267.74, 51.48 -60.48, -28.34 in-in in 8.8699 Saltbr-in 2.7695 HRD-in -93.55, -50.9 68.82, 8.95 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.63, 158.06 APE9-dihe-na 139.02, -156.91 APE8-dihe-in -126.94, 137.23 APE8-rot-in 299.54 APE67-dihe-in -64.26, -23.0 -50.4, -48.13 APE12-dist-in 8.1804 APE11-dist-in 11.5397 APE10-dist-in 5.9545 APE9-dist-in 3.7228 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.9 0.152 0.188 A 405.0 336.0 0 25 25 0 [[44, 298]] 1.0 4wb7 AGC_PRKACA_HUMAN AGC 7e-95 323.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB7B P17612 2 351 351.0 ATP:60501 ATPlike Active DFGin 5.3799 14.7121 BLAminus -115.93, -176.79 62.38, 75.33 -88.91, 25.18 264.71, 51.71 -56.9, -30.26 in-in in 8.9624 Saltbr-in 2.7732 HRD-in -94.01, -50.55 67.24, 10.48 in-in-in SNCiii in-in ActLoopNT-in 2.9391 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.07, 161.39 APE9-dihe-na 132.31, -156.17 APE8-dihe-in -127.2, 138.18 APE8-rot-in 298.14 APE67-dihe-in -59.62, -23.37 -52.63, -48.78 APE12-dist-in 8.1977 APE11-dist-in 11.5627 APE10-dist-in 5.9704 APE9-dist-in 3.6419 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.9 0.152 0.188 B 405.0 336.0 0 25 25 0 [[44, 298]] 1.0 4wb7 AGC_PRKACA_HUMAN AGC 7e-95 323.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6BYRA P17612 2 351 351.0 ATP:60501 ATPlike Active DFGin 5.6263 14.6159 BLAminus -128.29, 177.03 62.06, 86.64 -97.54, 28.59 271.87, 66.62 -63.2, -33.23 in-in in 8.8079 Saltbr-in 3.1965 HRD-in -87.43, -52.47 67.28, 5.18 in-in-in SNCiii in-in ActLoopNT-in 3.1931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.51, 153.24 APE9-dihe-na 149.32, -133.8 APE8-dihe-in -139.35, 133.91 APE8-rot-in 312.31 APE67-dihe-in -68.4, -6.95 -52.73, -48.25 APE12-dist-in 8.7341 APE11-dist-in 11.0763 APE10-dist-in 5.6298 APE9-dist-in 3.4915 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.661 0.203 0.249 A 405.0 336.0 0 25 25 0 [[44, 298]] 1.0 6byr AGC_PRKACA_HUMAN AGC 7e-95 323.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6BYRC P17612 2 351 351.0 ATP:60501 ATPlike Active DFGin 5.6794 14.3401 BLAminus -129.89, 172.29 61.76, 74.25 -79.2, 34.93 281.69, 54.14 -61.8, -27.34 in-in in 8.7335 Saltbr-in 2.4981 HRD-in -93.13, -49.8 64.55, 7.44 in-in-in SNCiii in-in ActLoopNT-in 3.0524 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.29, 161.94 APE9-dihe-na 130.51, -156.26 APE8-dihe-in -112.31, 134.09 APE8-rot-in 302.07 APE67-dihe-in -64.15, -16.52 -52.64, -41.39 APE12-dist-in 8.3162 APE11-dist-in 11.1062 APE10-dist-in 5.7667 APE9-dist-in 3.6182 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.661 0.203 0.249 C 405.0 336.0 0 25 25 0 [[44, 298]] 1.0 6byr AGC_PRKACA_HUMAN AGC 7e-95 323.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 9EDCA P17612 14 351 351.0 ATP:60400 ATPlike Active DFGin 5.6262 13.772 BLAminus -125.61, -173.52 60.53, 69.6 -81.59, 16.86 273.36, 51.23 -62.38, -30.28 in-in in 9.1286 Saltbr-in 2.9998 HRD-in -112.54, -46.7 65.17, 1.82 in-in-in SNCiii in-in ActLoopNT-in 3.1404 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.87, 159.92 APE9-dihe-na 136.42, -156.18 APE8-dihe-in -101.13, 126.83 APE8-rot-in 299.98 APE67-dihe-in -84.76, -8.6 -60.74, -28.35 APE12-dist-in 7.9989 APE11-dist-in 11.1115 APE10-dist-in 5.7968 APE9-dist-in 3.7475 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 EM 4.18 999.0 999.0 A 350.0 338.0 0 25 25 0 [[44, 298]] 1.0 9edc AGC_PRKACA_HUMAN AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 9EDDA P17612 14 351 351.0 ATP:60400 ATPlike Inactive DFGin 7.6417 15.4797 BLAminus -131.38, -176.44 56.47, 73.0 -86.17, 32.62 269.53, 53.11 -62.17, -29.29 in-out in 9.6174 Saltbr-out 3.9466 HRD-in -100.83, -51.39 64.03, -2.2 out-out-out SNCooo out-out ActLoopNT-out 3.7028 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.87, 141.16 APE9-dihe-na 150.41, -172.01 APE8-dihe-in -103.27, 147.74 APE8-rot-out 185.24 APE67-dihe-in -92.0, 3.92 -57.96, -27.57 APE12-dist-in 8.1647 APE11-dist-in 11.2754 APE10-dist-in 5.6275 APE9-dist-in 4.2273 None TPO198,SEP339 TPO198,SEP339 EM 6.3 999.0 999.0 A 350.0 338.0 0 25 25 0 [[44, 298]] 1.0 9edd AGC_PRKACA_HUMAN AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 9EDEA P17612 14 351 351.0 ATP:60400 ATPlike Inactive DFGin 6.6922 15.188 BLAminus -131.57, -176.8 59.06, 65.59 -87.14, 28.49 267.05, 50.71 -66.29, -36.64 in-out in 9.9219 Saltbr-out 4.6819 HRD-in -115.21, -49.18 64.38, 4.15 out-out-out SNCooo out-out ActLoopNT-out 3.632 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -122.67, 141.1 APE9-dihe-na 158.89, -177.66 APE8-dihe-in -75.58, 154.98 APE8-rot-out 190.35 APE67-dihe-in -109.16, -25.21 -65.33, -8.36 APE12-dist-in 8.3471 APE11-dist-in 11.7825 APE10-dist-in 6.8289 APE9-dist-in 4.9175 None TPO198,SEP339 TPO198,SEP339 EM 5.9 999.0 999.0 A 350.0 338.0 0 25 25 0 [[44, 298]] 1.0 9ede AGC_PRKACA_HUMAN AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB6A P17612 14 351 351.0 ATP:60401 ATPlike Active DFGin 6.0678 14.3977 BLAminus -118.38, -169.49 51.77, 82.47 -95.61, 17.78 271.18, 55.73 -42.8, -37.29 in-in in 8.8304 Saltbr-in 2.5613 HRD-in -94.17, -52.18 74.17, 2.46 in-in-in SNCiii in-in ActLoopNT-in 2.9483 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.55, 166.68 APE9-dihe-na 116.18, 128.45 APE8-dihe-in -46.62, 128.74 APE8-rot-in 303.5 APE67-dihe-in -58.01, -23.74 -49.09, -50.89 APE12-dist-in 8.0462 APE11-dist-in 11.764 APE10-dist-in 6.2427 APE9-dist-in 3.7665 L206R SEP11,SEP140,TPO198 SEP11,SEP140,TPO198 XRAY 2.1 0.19 0.237 A 350.0 338.0 0 25 25 0 [[44, 298]] 1.0 4wb6 AGC_PRKACA_HUMAN AGC 8.6e-94 319.5 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB6B P17612 9 351 351.0 ATP:60401 ATPlike Active DFGin 5.8721 14.0727 BLAminus -117.82, -168.32 53.27, 78.35 -91.25, 29.34 274.97, 62.46 -60.26, -35.85 in-in in 8.6873 Saltbr-in 2.7501 HRD-in -101.62, -46.5 64.42, 3.48 in-in-in SNCiii in-in ActLoopNT-in 2.9461 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.38, 164.15 APE9-dihe-na 120.83, 133.18 APE8-dihe-in -48.66, 125.41 APE8-rot-in 298.86 APE67-dihe-in -54.58, -37.6 -53.55, -42.52 APE12-dist-in 8.078 APE11-dist-in 11.6173 APE10-dist-in 6.2035 APE9-dist-in 3.8221 L206R SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.1 0.19 0.237 B 350.0 343.0 0 25 25 0 [[44, 298]] 1.0 4wb6 AGC_PRKACA_HUMAN AGC 8.6e-94 319.5 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKCI KPCI_HUMAN 3A8WA P41743 249 588 596.0 ATP:60601 ATPlike Inactive DFGin 5.1739 12.3776 BLAminus -132.69, 170.49 67.34, 88.86 -96.11, 11.96 304.5, 130.94 -60.46, -20.34 in-out in 8.3565 Saltbr-out 3.8823 HRD-in -61.87, -57.79 75.89, -1.36 out-in-in SNCoii in-in ActLoopNT-in 2.7712 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.32, 177.7 APE9-dihe-na 120.34, -178.18 APE8-dihe-in -99.49, 131.04 APE8-rot-in 301.47 APE67-dihe-in -55.52, -25.65 -39.88, -56.62 APE12-dist-in 8.7688 APE11-dist-in 11.7671 APE10-dist-in 6.2593 APE9-dist-in 3.6656 None TPO412,TPO564 TPO412,TPO564 XRAY 2.1 0.25 0.301 A 345.0 325.0 15 28 28 0 [[254, 522]] 1.0 3a8w AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 3A8WB P41743 249 588 596.0 ATP:60601 ATPlike Inactive DFGin 5.2569 12.3236 BLAminus -133.61, 172.63 64.84, 89.8 -97.52, 11.0 299.58, 138.75 -72.95, 35.24 in-out in 8.1924 Saltbr-out 3.9771 HRD-in -61.03, -56.18 70.75, 8.33 out-in-in SNCoii in-in ActLoopNT-in 2.9967 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -171.82, 179.6 APE9-dihe-na 132.39, -163.28 APE8-dihe-in -113.8, 132.71 APE8-rot-in 303.74 APE67-dihe-in -61.94, -22.49 -35.42, -58.51 APE12-dist-in 8.7599 APE11-dist-in 11.7256 APE10-dist-in 6.5394 APE9-dist-in 3.7699 None TPO412,TPO564 TPO412,TPO564 XRAY 2.1 0.25 0.301 B 345.0 326.0 14 28 25 3 [[254, 522]] 1.0 3a8w AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKG1 KGP1_HUMAN 7T4TA Q13976 204 671 671.0 PCG:60701,ATP:60702 Allosteric,ATPlike Inactive DFGin 5.8055 14.9328 ABAminus -123.17, -29.2 -107.96, 118.17 -112.33, 30.1 285.53, 74.3 -67.24, -29.77 in-in in 9.5568 Saltbr-in 3.3803 HRD-in -86.67, -51.63 61.2, 10.68 in-in-in SNCiii in-in ActLoopNT-in 2.8595 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -166.89, 164.61 APE9-dihe-na 124.7, -170.63 APE8-dihe-in -100.54, 134.31 APE8-rot-in 302.38 APE67-dihe-in -67.0, -27.98 -44.1, -43.89 APE12-dist-in 7.9413 APE11-dist-in 10.7126 APE10-dist-in 5.3076 APE9-dist-in 3.712 None TPO517 TPO517 XRAY 2.08 0.19 0.221 A 469.0 453.0 0 27 27 0 [[360, 619]] 1.0 7t4t AGC_PRKG1_HUMAN AGC 6.4e-84 287.2 1.0 260.0 260.0 501 502 503 505 507 390 409 413 481 483 482 484.0 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7T4TB Q13976 204 671 671.0 PCG:60701,ATP:60702 Allosteric,ATPlike Inactive DFGin 5.8004 14.8112 ABAminus -121.38, -38.76 -100.76, 117.73 -112.4, 30.34 285.48, 73.71 -68.75, -29.12 in-in in 9.4009 Saltbr-in 3.3105 HRD-in -86.82, -51.68 61.52, 10.16 in-in-in SNCiii in-in ActLoopNT-in 2.8534 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.5, 164.27 APE9-dihe-na 124.32, -169.95 APE8-dihe-in -101.18, 134.26 APE8-rot-in 302.8 APE67-dihe-in -67.54, -26.94 -44.3, -44.01 APE12-dist-in 7.9575 APE11-dist-in 10.7572 APE10-dist-in 5.3357 APE9-dist-in 3.7168 None TPO517 TPO517 XRAY 2.08 0.19 0.221 B 469.0 453.0 0 27 27 0 [[360, 619]] 1.0 7t4t AGC_PRKG1_HUMAN AGC 6.4e-84 287.2 1.0 260.0 260.0 501 502 503 505 507 390 409 413 481 483 482 484.0 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
CAMK AURKA AURKA_HUMAN 5DNRA O14965 126 390 403.0 ATP:403 ATPlike Inactive DFGin 5.6553 15.0245 BLAminus -132.27, -179.72 60.78, 76.64 -90.12, 18.66 275.93, 74.44 -56.64, -35.89 in-in in 9.1663 Saltbr-in 2.7468 HRD-in -79.07, -53.73 71.53, 2.24 in-in-out SNCiio in-out ActLoopNT-in 2.9452 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -125.56, 5.88 APE9-dihe-na -79.83, -178.97 APE8-dihe-in -49.83, 123.63 APE8-rot-in 300.84 APE67-dihe-in -48.83, -30.32 -94.71, -13.22 APE12-dist-in 9.3475 APE11-dist-in 13.1152 APE10-dist-out 15.9471 APE9-dist-out 11.2037 None TPO288 TPO288 XRAY 1.95 0.206 0.226 A 272.0 265.0 0 26 26 0 [[133, 383]] 1.0 5dnr CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DT3A O14965 127 390 403.0 ATP:403 ATPlike Inactive DFGin 5.7307 15.0475 BLAminus -138.47, 178.42 59.62, 78.35 -90.84, 24.83 281.41, 74.26 -61.06, -31.68 in-in in 9.4512 Saltbr-in 2.9168 HRD-in -69.42, -55.99 70.31, -3.53 in-in-out SNCiio in-out ActLoopNT-in 2.8923 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -112.53, -5.85 APE9-dihe-na -110.59, -164.26 APE8-dihe-in -61.03, 149.68 APE8-rot-out 193.86 APE67-dihe-in -45.37, -39.19 -93.82, -1.33 APE12-dist-in 12.1815 APE11-dist-in 10.015 APE10-dist-out 11.6945 APE9-dist-out 10.4874 None TPO287 TPO287 XRAY 2.33 0.21 0.243 A 273.0 264.0 0 26 26 0 [[133, 383]] 1.0 5dt3 CAMK_AURKA_HUMAN CAMK 6.5e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DRDA O14965 127 390 403.0 ATP:402 ATPlike Inactive DFGin 6.1794 15.4902 BLAminus -124.75, -173.07 54.37, 73.03 -91.89, 14.82 276.39, 76.92 -60.47, -27.86 in-in in 9.0942 Saltbr-in 2.7117 HRD-in -86.49, -50.72 75.89, 5.8 in-in-out SNCiio in-out ActLoopNT-in 3.0093 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -110.08 APE9-dihe-na -77.61, -136.85 APE8-dihe-in -63.84, 145.87 APE8-rot-out 199.39 APE67-dihe-in -52.56, -31.45 -96.52, -6.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.8473 APE9-dist-out 10.6226 T287A None None XRAY 2.13 0.209 0.262 A 273.0 259.0 5 26 21 5 [[133, 383]] 1.0 5drd CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 1OL6A O14965 128 388 403.0 ATP:1388 ATPlike Inactive DFGin 5.8513 15.6403 BLAminus -135.92, 178.5 52.45, 77.03 -92.23, 24.52 292.21, 75.73 -61.17, -14.48 in-out in 9.9117 Saltbr-out 4.6692 HRD-in -62.99, -55.9 71.29, 3.18 out-in-none SNCoin in-none ActLoopNT-in 3.0994 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.06 APE8-rot-in 336.17 APE67-dihe-in -65.51, -21.75 -47.85, -55.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D274N None None XRAY 3.0 0.277 0.301 A 282.0 246.0 15 26 15 11 [[133, 383]] 1.0 1ol6 CAMK_AURKA_HUMAN CAMK 4.4e-79 271.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DN3A O14965 125 389 403.0 5DN:402,ATP:404 Allosteric,ATPlike Inactive DFGin 5.6992 15.0424 BLAminus -130.89, -174.42 55.28, 74.81 -88.98, 14.12 275.51, 75.93 -51.92, -35.15 in-in in 9.1659 Saltbr-in 2.7201 HRD-in -77.57, -53.05 71.13, 1.06 in-in-out SNCiio in-out ActLoopNT-in 2.9564 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -118.61, -13.13 APE9-dihe-na -74.86, -176.69 APE8-dihe-in -54.45, 125.21 APE8-rot-in 310.73 APE67-dihe-in -44.24, -34.14 -96.33, -16.24 APE12-dist-in 9.4351 APE11-dist-in 13.2348 APE10-dist-out 15.6674 APE9-dist-out 11.2317 None TPO288 TPO288 XRAY 2.05 0.192 0.203 A 272.0 265.0 0 26 26 0 [[133, 383]] 1.0 5dn3 CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1EA O14965 127 388 403.0 T0X:401,ATP:403 Allosteric,ATPlike Inactive DFGin 5.7981 14.8074 BLAminus -150.0, 179.01 57.43, 76.53 -96.95, 20.99 278.49, 67.97 -56.09, -34.21 in-in in 9.1906 Saltbr-in 2.8469 HRD-in -74.81, -56.51 74.42, -5.07 in-in-out SNCiio in-out ActLoopNT-in 2.6152 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -165.45, 99.75 APE9-dihe-na -118.34, -95.63 APE8-dihe-in -111.54, 127.78 APE8-rot-in 354.95 APE67-dihe-in -38.77, -37.51 -96.45, -21.24 APE12-dist-in 9.259 APE11-dist-in 13.5443 APE10-dist-out 15.2592 APE9-dist-out 10.8956 None TPO288 TPO288 XRAY 2.798 0.176 0.239 A 272.0 262.0 0 26 26 0 [[133, 383]] 1.0 8c1e CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DT4A O14965 127 390 403.0 5DN:402,ATP:403 Allosteric,ATPlike Inactive DFGin 6.0226 15.016 BLAminus -131.6, -179.1 56.58, 87.02 -103.91, 25.71 282.11, 78.42 -59.32, -42.3 in-in in 9.5441 Saltbr-in 3.0038 HRD-in -66.18, -52.21 66.74, -14.36 in-in-out SNCiio in-out ActLoopNT-in 2.9439 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -57.69 APE9-dihe-na -89.02, -152.47 APE8-dihe-in -67.56, 141.58 APE8-rot-out 191.42 APE67-dihe-in -59.88, -41.29 -85.27, 2.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.1589 APE9-dist-out 9.9725 None None None XRAY 2.86 0.193 0.256 A 273.0 259.0 5 26 21 5 [[133, 383]] 1.0 5dt4 CAMK_AURKA_HUMAN CAMK 6.5e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DOSA O14965 127 390 403.0 5DN:402,ATP:403 Allosteric,ATPlike Inactive DFGin 5.9 15.0444 BLAminus -141.11, -178.41 56.44, 85.64 -101.51, 29.55 282.61, 75.97 -61.45, -42.65 in-in in 9.4934 Saltbr-in 2.8607 HRD-in -75.29, -42.25 59.65, -8.83 in-in-out SNCiio in-out ActLoopNT-in 3.0424 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -79.83 APE9-dihe-na -91.08, -144.18 APE8-dihe-in -65.26, 123.97 APE8-rot-out 190.75 APE67-dihe-in -25.49, -64.25 -63.86, -31.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.0331 APE9-dist-out 9.7933 T287A None None XRAY 2.98 0.201 0.273 A 273.0 259.0 5 26 21 5 [[133, 383]] 1.0 5dos CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DR2A O14965 128 390 403.0 5E1:60401,ATP:60403 Allosteric,ATPlike Inactive DFGin 5.7419 15.1483 BLAminus -112.74, -178.24 59.1, 85.93 -103.74, 31.08 282.48, 80.94 -64.76, -39.96 in-in in 9.2247 Saltbr-in 2.8451 HRD-in -83.01, -54.44 78.2, -2.4 in-in-out SNCiio in-out ActLoopNT-in 2.8713 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -117.43, 59.62 APE9-dihe-na -131.57, -163.05 APE8-dihe-in -74.95, 143.42 APE8-rot-out 161.96 APE67-dihe-in -60.88, -32.64 -91.05, 11.96 APE12-dist-in 12.5259 APE11-dist-in 9.1209 APE10-dist-out 12.6318 APE9-dist-out 10.0391 T287A None None XRAY 2.46 0.225 0.285 A 273.0 263.0 0 26 26 0 [[133, 383]] 1.0 5dr2 CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OBJA O14965 127 390 403.0 ATP:404,9QK:405 ATPlike,Allosteric Inactive DFGin 6.016 15.9671 None -127.31, -156.34 57.9, -96.92 69.6, 25.6 277.68, 99.91 -74.82, -34.09 out-out out 10.8688 Saltbr-out 3.9746 HRD-in -84.35, -43.15 67.43, 1.86 out-in-out SNCoio in-out ActLoopNT-in 2.747 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -85.06 APE9-dihe-na -106.73, -153.17 APE8-dihe-in -86.88, 144.13 APE8-rot-in 279.73 APE67-dihe-in -52.07, -35.29 -66.02, -11.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.3791 APE9-dist-out 10.1992 None None None XRAY 2.901 0.215 0.245 A 272.0 260.0 4 26 22 4 [[133, 383]] 1.0 5obj CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK CAMK1 KCC1A_HUMAN 4FG7A Q14012 9 277 370.0 ATP:301 ATPlike None DFGin 6.7328 14.5583 BLAminus -139.66, 179.97 56.25, 83.23 -95.06, 23.76 286.93, 75.78 -57.64, -10.34 in-in in 9.7564 Saltbr-in 2.9877 HRD-in -66.62, -51.56 76.61, -3.11 in-in-none SNCiin in-none ActLoopNT-in 2.9676 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 148.43 APE8-dihe-in -71.0, 118.39 APE8-rot-in 317.82 APE67-dihe-inflip 114.74, -42.57 -57.89, 141.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.1487 None None None XRAY 2.7 0.221 0.246 A 293.0 250.0 19 27 19 8 [[20, 276]] 1.0 4fg7 CAMK_CAMK1_HUMAN CAMK 6.7e-97 329.7 1.0 256.0 256.0 161 162 163 165 167 49 66 70 138 140 139 141.0 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1 KCC1A_HUMAN 4FG9A Q14012 10 314 370.0 ATP:401 ATPlike Inactive DFGinter 6.3717 9.9232 None -94.72, -48.11 -72.17, 151.42 -111.14, 999.0 291.22, 108.3 999.0, 999.0 out-out out 13.2506 Saltbr-out 11.2127 HRD-in -52.69, -68.08 75.14, -19.91 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 133.2, -24.01 999.0, 22.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.211 0.249 A 320.0 278.0 27 27 9 18 [[20, 276]] 1.0 4fg9 CAMK_CAMK1_HUMAN CAMK 9.2e-97 329.5 1.0 256.0 256.0 161 162 163 165 167 49 66 70 138 140 139 141.0 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1 KCC1A_HUMAN 4FG9B Q14012 14 314 370.0 ATP:401 ATPlike Inactive DFGinter 6.2867 9.3242 None -97.62, -42.8 -76.25, 145.4 -105.57, 999.0 303.86, 102.8 999.0, 999.0 out-none out 16.8995 Saltbr-none 999.0 HRD-in -42.26, -58.83 67.77, -17.08 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na -80.77, -34.84 APE9-dihe-na -79.39, -52.09 APE8-dihe-in -108.11, 99.06 APE8-rot-none 999.0 APE67-dihe-inflip 97.92, -38.15 -85.42, 136.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5299 None None None XRAY 2.4 0.211 0.249 B 320.0 279.0 22 27 17 10 [[20, 276]] 1.0 4fg9 CAMK_CAMK1_HUMAN CAMK 9.2e-97 329.5 1.0 256.0 256.0 161 162 163 165 167 49 66 70 138 140 139 141.0 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1 KCC1A_HUMAN 4FG8A Q14012 10 299 370.0 ATP:401 ATPlike Inactive None 999.0 999.0 None -88.48, -49.15 -70.71, 166.62 -106.58, 999.0 999.0, 999.0 999.0, 999.0 out-none out 14.285 Saltbr-none 999.0 HRD-in -68.76, -57.94 73.69, -12.61 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -41.56 APE8-rot-none 999.0 APE67-dihe-out 113.32, -70.06 -37.24, 130.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.198 0.248 A 315.0 263.0 27 27 10 17 [[20, 276]] 1.0 4fg8 CAMK_CAMK1_HUMAN CAMK 8.7e-97 329.4 1.0 256.0 256.0 161 162 163 165 167 49 66 70 138 140 139 141.0 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1 KCC1A_HUMAN 4FG8B Q14012 14 299 370.0 ATP:401 ATPlike Inactive None 999.0 999.0 None -101.4, -28.72 -75.18, 152.13 -127.71, -74.73 999.0, 999.0 -143.25, 999.0 out-none out 14.4967 Saltbr-none 999.0 HRD-in -60.93, -60.01 82.66, -21.6 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaino APEdist_nnno APE10-dihe-na -81.34, -37.41 APE9-dihe-na -69.8, -52.82 APE8-dihe-in -110.8, 85.13 APE8-rot-none 999.0 APE67-dihe-out 122.52, -61.56 -92.65, 135.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.9518 None None None XRAY 2.2 0.198 0.248 B 315.0 268.0 18 27 20 7 [[20, 276]] 1.0 4fg8 CAMK_CAMK1_HUMAN CAMK 8.7e-97 329.4 1.0 256.0 256.0 161 162 163 165 167 49 66 70 138 140 139 141.0 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK2A KCC2A_HUMAN 7UIRA Q9UQM7 7 274 478.0 ATP:302 ATPlike Active DFGin 6.0448 15.1065 BLAminus -137.0, 179.68 44.28, 101.28 -106.42, 24.78 295.79, 81.95 -53.14, -27.06 in-in in 9.8503 Saltbr-in 3.4665 HRD-in -74.22, -43.69 67.52, 3.92 in-in-in SNCiii in-in ActLoopNT-in 2.9094 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.48, 156.41 APE9-dihe-na 131.95, -156.1 APE8-dihe-in -122.09, 129.91 APE8-rot-in 298.28 APE67-dihe-in -55.12, -36.11 -51.43, -40.3 APE12-dist-in 10.3326 APE11-dist-in 11.7934 APE10-dist-in 6.0556 APE9-dist-in 3.4247 D135N,Q223K None None XRAY 3.1 0.234 0.274 A 268.0 268.0 0 28 28 0 [[13, 271]] 1.0 7uir CAMK_CAMK2A_HUMAN CAMK 9.3e-96 326.0 1.0 256.0 256.0 155 156 157 159 161 42 60 64 132 134 133 135.0 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 7UIRB Q9UQM7 7 273 478.0 ATP:301 ATPlike Active DFGin 6.0928 14.4626 BLAminus -136.84, -179.4 43.86, 99.82 -105.8, 24.57 296.99, 81.24 -56.04, -26.17 in-in in 9.4034 Saltbr-in 3.0273 HRD-in -74.93, -42.65 67.84, 3.24 in-in-in SNCiii in-in ActLoopNT-in 2.9153 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.86, 157.92 APE9-dihe-na 132.59, -155.55 APE8-dihe-in -122.09, 129.05 APE8-rot-in 298.73 APE67-dihe-in -54.7, -35.97 -51.63, -40.47 APE12-dist-in 10.3035 APE11-dist-in 11.733 APE10-dist-in 5.9892 APE9-dist-in 3.5041 D135N,Q223K None None XRAY 3.1 0.234 0.274 B 268.0 261.0 6 28 28 0 [[13, 271]] 1.0 7uir CAMK_CAMK2A_HUMAN CAMK 9.3e-96 326.0 1.0 256.0 256.0 155 156 157 159 161 42 60 64 132 134 133 135.0 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 7UJPB Q9UQM7 7 273 478.0 ATP:301 ATPlike Active DFGin 6.9424 14.3134 BLAminus -133.64, 174.92 62.39, 75.15 -97.38, 27.07 283.14, 81.65 -64.42, -25.12 in-in in 8.5581 Saltbr-in 2.7832 HRD-in -76.01, -51.46 77.74, -9.31 in-in-in SNCiii in-in ActLoopNT-in 2.8708 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.94, 139.06 APE9-dihe-na 146.74, -166.31 APE8-dihe-in -115.05, 124.1 APE8-rot-in 308.42 APE67-dihe-in -69.31, -14.12 -35.51, -54.36 APE12-dist-in 10.2497 APE11-dist-in 11.5916 APE10-dist-in 5.8425 APE9-dist-in 3.5719 D135N,Q223K None None XRAY 2.56 0.234 0.281 B 268.0 267.0 0 28 28 0 [[13, 271]] 1.0 7ujp CAMK_CAMK2A_HUMAN CAMK 9.3e-96 326.0 1.0 256.0 256.0 155 156 157 159 161 42 60 64 132 134 133 135.0 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 7UJTA Q9UQM7 7 274 478.0 ATP:301 ATPlike Inactive DFGin 5.7931 15.8712 BLAminus -136.06, 173.98 63.2, 83.03 -96.5, 26.66 288.93, 81.42 -61.86, -26.9 out-out out 10.3543 Saltbr-out 4.9623 HRD-in -68.86, -51.05 77.4, -6.28 out-in-in SNCoii in-in ActLoopNT-in 2.8651 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.17, 142.76 APE9-dihe-na 138.67, -159.02 APE8-dihe-in -111.71, 119.97 APE8-rot-in 304.14 APE67-dihe-in -65.52, -19.91 -39.43, -49.22 APE12-dist-in 10.4065 APE11-dist-in 11.7914 APE10-dist-in 5.962 APE9-dist-in 3.8351 D135N,Q223K None None XRAY 2.1 0.205 0.246 A 268.0 268.0 0 28 28 0 [[13, 271]] 1.0 7ujt CAMK_CAMK2A_HUMAN CAMK 9.3e-96 326.0 1.0 256.0 256.0 155 156 157 159 161 42 60 64 132 134 133 135.0 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK PHKG1 PHKG1_HUMAN 8Z5RC Q16816 12 383 387.0 ATP:401 ATPlike Inactive DFGin 6.2158 15.7899 BLAminus -134.62, -175.38 59.67, 63.56 -84.41, -0.54 270.17, 147.24 -63.63, -41.24 out-none out 10.4151 Saltbr-none 999.0 HRD-in -97.74, -41.95 55.77, 14.53 none-out-in SNCnoi out-in ActLoopNT-out 3.722 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.82, 162.86 APE9-dihe-na 112.58, 179.42 APE8-dihe-in -65.24, 137.27 APE8-rot-in 278.19 APE67-dihe-in -93.32, 13.97 -60.86, -18.95 APE12-dist-in 9.6172 APE11-dist-in 12.1625 APE10-dist-in 7.279 APE9-dist-in 5.4521 None None None EM 3.52 999.0 999.0 C 387.0 372.0 0 27 27 0 [[20, 288]] 1.0 8z5r CAMK_PHKG1_HUMAN CAMK 1.4e-85 292.7 1.0 256.0 256.0 167 168 169 171 173 49 74 78 147 149 148 150.0 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK PHKG1 PHKG1_HUMAN 8Z5TC Q16816 12 383 387.0 ATP:401 ATPlike Inactive DFGin 5.9663 13.9887 BLAminus -135.48, -169.66 58.09, 63.88 -81.9, 2.43 303.6, 100.06 -62.94, -40.27 out-none out 10.6871 Saltbr-none 999.0 HRD-in -92.65, -46.31 62.21, 13.41 none-out-in SNCnoi out-in ActLoopNT-out 3.7863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.91, 163.41 APE9-dihe-na 112.45, -178.89 APE8-dihe-in -64.37, 134.79 APE8-rot-in 304.3 APE67-dihe-in -88.43, 6.38 -60.59, -20.91 APE12-dist-in 9.3478 APE11-dist-in 12.0888 APE10-dist-in 7.2113 APE9-dist-in 5.3437 None None None EM 3.74 999.0 999.0 C 387.0 372.0 0 27 27 0 [[20, 288]] 1.0 8z5t CAMK_PHKG1_HUMAN CAMK 1.4e-85 292.7 1.0 256.0 256.0 167 168 169 171 173 49 74 78 147 149 148 150.0 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK PHKG1 PHKG1_HUMAN 8Z5TG Q16816 12 383 387.0 ATP:401 ATPlike Inactive DFGin 6.2112 16.3499 BLAminus -138.41, -165.95 59.18, 62.46 -88.91, 3.24 271.18, 147.97 -59.75, -36.25 out-none out 10.6402 Saltbr-none 999.0 HRD-in -91.86, -44.41 50.14, 19.86 none-out-out SNCnoo out-out ActLoopNT-out 3.7877 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -170.81, -171.47 APE9-dihe-na 86.12, 176.52 APE8-dihe-in -63.45, 134.1 APE8-rot-in 318.38 APE67-dihe-in -94.57, 4.67 -60.84, -20.41 APE12-dist-in 10.0986 APE11-dist-out 14.0191 APE10-dist-out 9.0465 APE9-dist-in 5.8328 None None None EM 3.74 999.0 999.0 G 387.0 372.0 0 27 27 0 [[20, 288]] 1.0 8z5t CAMK_PHKG1_HUMAN CAMK 1.4e-85 292.7 1.0 256.0 256.0 167 168 169 171 173 49 74 78 147 149 148 150.0 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK PHKG1 PHKG1_HUMAN 8Z5TK Q16816 12 383 387.0 ATP:401 ATPlike Inactive DFGin 6.8189 16.4302 BLAminus -134.15, -169.32 57.8, 62.87 -86.64, 0.65 265.34, 130.05 -62.73, -39.71 out-none out 10.3313 Saltbr-none 999.0 HRD-in -97.03, -55.84 67.06, 16.56 none-out-in SNCnoi out-in ActLoopNT-out 3.8051 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.95, 163.43 APE9-dihe-na 106.51, -175.76 APE8-dihe-in -64.59, 130.37 APE8-rot-in 311.03 APE67-dihe-in -88.59, 5.57 -61.92, -16.15 APE12-dist-in 9.5541 APE11-dist-in 12.2731 APE10-dist-in 7.3662 APE9-dist-in 5.2682 None None None EM 3.74 999.0 999.0 K 387.0 372.0 0 27 27 0 [[20, 288]] 1.0 8z5t CAMK_PHKG1_HUMAN CAMK 1.4e-85 292.7 1.0 256.0 256.0 167 168 169 171 173 49 74 78 147 149 148 150.0 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK PHKG1 PHKG1_HUMAN 8Z5TO Q16816 12 383 387.0 ATP:401 ATPlike Inactive DFGin 6.3258 15.7903 BLAminus -126.17, -170.44 58.71, 63.18 -85.3, 0.59 276.38, 60.06 -63.17, -41.01 out-none out 10.5393 Saltbr-none 999.0 HRD-in -82.25, -48.84 62.3, 10.36 none-out-in SNCnoi out-in ActLoopNT-out 3.6965 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.09, 163.04 APE9-dihe-na 110.51, -176.12 APE8-dihe-in -65.19, 138.82 APE8-rot-in 315.28 APE67-dihe-in -94.37, 8.66 -62.65, -15.41 APE12-dist-in 9.5578 APE11-dist-in 12.0862 APE10-dist-in 7.1947 APE9-dist-in 5.5204 None None None EM 3.74 999.0 999.0 O 387.0 372.0 0 27 27 0 [[20, 288]] 1.0 8z5t CAMK_PHKG1_HUMAN CAMK 1.4e-85 292.7 1.0 256.0 256.0 167 168 169 171 173 49 74 78 147 149 148 150.0 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK STK17B ST17B_HUMAN 7Q7DA O94768 25 297 372.0 ATP:60401 ATPlike Inactive DFGin 5.9795 13.9807 BLAminus -131.01, 179.34 62.41, 83.11 -104.07, 20.6 289.75, 84.41 -62.74, -20.86 in-in in 9.3477 Saltbr-in 3.5375 HRD-in -65.32, -50.49 69.46, 8.5 in-in-out SNCiio in-out ActLoopNT-in 3.0576 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -156.23, 8.1 APE9-dihe-na -82.21, -176.47 APE8-dihe-in -53.98, 115.12 APE8-rot-in 320.45 APE67-dihe-in -72.35, -13.63 -52.11, -32.33 APE12-dist-in 7.7479 APE11-dist-in 12.291 APE10-dist-out 11.2185 APE9-dist-out 7.5968 None None None XRAY 2.6 0.196 0.235 A 327.0 273.0 0 27 27 0 [[32, 293]] 1.0 7q7d CAMK_STK17B_HUMAN CAMK 1.4e-81 279.8 4.0 256.0 253.0 178 179 180 182 184 62 80 84 155 157 156 158.0 217 205 200 199 198 197 196 195 194 111 Serine/threonine-protein kinase 17B
CAMK STK17B ST17B_HUMAN 7Q7EA O94768 25 297 372.0 ATP:60401 ATPlike Inactive DFGin 5.8059 13.997 BLAminus -136.48, 179.08 63.28, 89.42 -111.5, 27.32 288.43, 87.78 -70.0, -15.51 in-in in 9.3126 Saltbr-in 3.1174 HRD-in -75.17, -47.59 66.91, 14.25 in-in-out SNCiio in-out ActLoopNT-in 3.4002 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -119.2, -9.71 APE9-dihe-na -66.55, 174.56 APE8-dihe-in -49.86, 121.22 APE8-rot-in 313.96 APE67-dihe-in -70.36, -7.82 -52.35, -34.48 APE12-dist-in 7.3784 APE11-dist-in 12.1105 APE10-dist-out 10.7897 APE9-dist-out 7.473 None None None XRAY 2.85 0.191 0.239 A 327.0 273.0 0 27 27 0 [[32, 293]] 1.0 7q7e CAMK_STK17B_HUMAN CAMK 1.4e-81 279.8 4.0 256.0 253.0 178 179 180 182 184 62 80 84 155 157 156 158.0 217 205 200 199 198 197 196 195 194 111 Serine/threonine-protein kinase 17B
CK1 TTBK1 TTBK1_HUMAN 4BTJB Q5TCY1 21 313 1321.0 ATP:61338 ATPlike Active DFGin 5.3516 12.7176 BLAminus -122.53, 168.88 60.17, 88.3 -98.51, 13.52 307.1, 115.33 -64.8, -32.06 in-in in 7.1484 Saltbr-in 2.816 HRD-in -78.94, -51.75 72.7, -0.47 in-in-in SNCiii in-in ActLoopNT-in 2.7477 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.82, -14.94 APE9-dihe-na -62.51, -161.18 APE8-dihe-in -100.71, 125.28 APE8-rot-in 309.68 APE67-dihe-in -55.66, -43.07 -52.23, -50.62 APE12-dist-in 11.0775 APE11-dist-in 10.8163 APE10-dist-in 6.4629 APE9-dist-in 4.3282 None None None XRAY 2.16 0.179 0.197 B 337.0 293.0 0 34 34 0 [[34, 295]] 1.0 4btj CK1_TTBK1_HUMAN CK1 5.7e-105 356.4 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
CMGC CDK2 CDK2_HUMAN 4EOOA P24941 1 297 298.0 ATP:60302 ATPlike Inactive DFGin 6.651 15.121 BLAminus -137.3, -178.29 51.93, 74.48 -88.78, 23.73 283.58, 71.37 -66.89, -17.34 in-in in 8.7539 Saltbr-in 2.7738 HRD-in -82.21, -55.51 72.81, 10.91 in-in-out SNCiio in-out ActLoopNT-in 2.8784 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.74, 151.81 APE9-dihe-na 71.22, 125.56 APE8-dihe-in -63.52, 145.17 APE8-rot-out 106.26 APE67-dihe-in -59.56, -25.92 -46.12, -48.45 APE12-dist-in 12.954 APE11-dist-in 10.3073 APE10-dist-in 7.1329 APE9-dist-in 3.2473 Q131E TPO160 TPO160 XRAY 2.1 0.216 0.253 A 299.0 293.0 4 28 28 0 [[4, 286]] 1.0 4eoo CMGC_CDK2_HUMAN CMGC 3.7e-90 308.6 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOOC P24941 1 296 298.0 ATP:60301 ATPlike Inactive DFGin 6.4414 15.2546 BLAminus -132.94, -176.35 50.17, 74.17 -84.23, 27.4 283.88, 71.77 -62.65, -24.02 in-in in 8.772 Saltbr-in 2.7246 HRD-in -84.21, -52.66 66.89, 14.22 in-in-out SNCiio in-out ActLoopNT-in 2.986 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -124.67, 158.22 APE9-dihe-na 65.39, 129.96 APE8-dihe-in -70.44, 149.36 APE8-rot-out 84.06 APE67-dihe-in -53.86, -24.11 -49.71, -53.55 APE12-dist-in 12.8075 APE11-dist-in 10.0033 APE10-dist-in 6.7498 APE9-dist-in 3.2864 Q131E TPO160 TPO160 XRAY 2.1 0.216 0.253 C 299.0 296.0 0 28 28 0 [[4, 286]] 1.0 4eoo CMGC_CDK2_HUMAN CMGC 3.7e-90 308.6 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOMA P24941 1 297 298.0 ATP:60301 ATPlike Inactive DFGin 6.7655 15.173 BLAminus -135.89, -179.95 56.75, 76.33 -93.68, 18.3 281.75, 72.51 -65.02, -17.06 in-in in 8.6563 Saltbr-in 2.9544 HRD-in -79.7, -58.84 74.79, 7.53 in-in-out SNCiio in-out ActLoopNT-in 2.8551 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na 71.17, 129.47 APE9-dihe-na 73.49, 129.68 APE8-dihe-in -66.58, 140.55 APE8-rot-out 117.21 APE67-dihe-in -54.12, -27.93 -44.4, -51.19 APE12-dist-in 13.2687 APE11-dist-in 9.2266 APE10-dist-in 7.1533 APE9-dist-in 3.2593 H84S,Q85M,Q131E TPO160 TPO160 XRAY 2.1 0.21 0.243 A 301.0 295.0 2 28 28 0 [[4, 286]] 1.0 4eom CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOMC P24941 1 296 298.0 ATP:60301 ATPlike Inactive DFGin 6.6125 15.1214 BLAminus -134.3, 179.46 56.9, 73.57 -89.28, 27.08 288.28, 71.72 -61.57, -29.46 in-in in 8.464 Saltbr-in 2.7643 HRD-in -79.86, -55.51 70.21, 14.99 in-in-out SNCiio in-out ActLoopNT-in 2.9883 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.3, 158.32 APE9-dihe-na 61.45, 125.91 APE8-dihe-in -61.76, 140.91 APE8-rot-out 72.97 APE67-dihe-in -49.53, -25.94 -36.27, -61.03 APE12-dist-in 12.8462 APE11-dist-in 9.6798 APE10-dist-in 6.9437 APE9-dist-in 3.3597 H84S,Q85M,Q131E TPO160 TPO160 XRAY 2.1 0.21 0.243 C 301.0 272.0 24 28 28 0 [[4, 286]] 1.0 4eom CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1FINA P24941 1 298 298.0 ATP:299 ATPlike Inactive DFGin 6.2688 15.3969 BLAminus -145.66, 175.42 60.17, 70.41 -88.62, 22.31 287.3, 65.31 -62.81, -23.63 in-in in 8.878 Saltbr-in 3.0657 HRD-in -75.81, -52.6 66.76, 11.52 in-in-out SNCiio in-out ActLoopNT-in 2.8478 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -159.69, 149.42 APE9-dihe-na -56.35, 161.85 APE8-dihe-in -65.27, 149.59 APE8-rot-out 191.08 APE67-dihe-in -48.48, -30.03 -41.87, -56.23 APE12-dist-in 10.4278 APE11-dist-out 5.9243 APE10-dist-out 8.9912 APE9-dist-in 4.1466 None None None XRAY 2.3 0.208 999.0 A 298.0 298.0 0 28 28 0 [[4, 286]] 1.0 1fin CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1FINC P24941 1 298 298.0 ATP:299 ATPlike Inactive DFGin 6.3292 16.1138 BLAminus -126.26, 177.09 60.06, 80.37 -100.41, 24.94 280.63, 71.46 -64.88, -37.23 in-in in 9.2342 Saltbr-in 3.0157 HRD-in -71.64, -45.48 67.73, -0.73 in-in-out SNCiio in-out ActLoopNT-in 2.6571 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -100.08, 164.84 APE9-dihe-na -64.11, 161.66 APE8-dihe-in -58.82, 141.21 APE8-rot-in 296.75 APE67-dihe-in -52.5, -36.66 -49.82, -46.41 APE12-dist-in 10.426 APE11-dist-out 6.2386 APE10-dist-out 9.723 APE9-dist-in 3.9072 None None None XRAY 2.3 0.208 999.0 C 298.0 298.0 0 28 28 0 [[4, 286]] 1.0 1fin CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1FQ1B P24941 1 296 298.0 ATP:381 ATPlike Inactive DFGin 6.7737 15.6217 BLAminus -151.24, -169.54 37.68, 67.63 -81.17, 26.85 274.26, 50.62 -66.75, -18.36 in-out in 9.807 Saltbr-out 3.7302 HRD-in -76.57, -60.94 80.93, -25.61 out-in-out SNCoio in-out ActLoopNT-in 2.6096 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oioo APE10-dihe-na -104.21, 92.46 APE9-dihe-na -93.56, -175.8 APE8-dihe-out -64.18, -46.74 APE8-rot-in 317.22 APE67-dihe-out -56.53, -27.84 69.72, -12.02 APE12-dist-out 16.1127 APE11-dist-in 11.9019 APE10-dist-out 15.5944 APE9-dist-out 10.1307 None TPO160 TPO160 XRAY 3.0 0.235 0.313 B 298.0 296.0 0 28 28 0 [[4, 286]] 1.0 1fq1 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1JSTA P24941 1 298 298.0 ATP:300 ATPlike Active DFGin 6.4269 15.4642 BLAminus -139.88, 179.46 48.93, 78.76 -92.24, 30.29 284.11, 71.63 -70.08, -30.4 in-in in 8.7168 Saltbr-in 2.7569 HRD-in -78.76, -47.67 60.69, 17.81 in-in-in SNCiii in-in ActLoopNT-in 2.9493 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.53, 164.64 APE9-dihe-na 80.72, 135.16 APE8-dihe-in -62.71, 138.95 APE8-rot-in 293.52 APE67-dihe-in -51.22, -30.94 -33.79, -62.16 APE12-dist-in 13.1212 APE11-dist-in 11.9337 APE10-dist-in 7.067 APE9-dist-in 3.2775 None TPO160 TPO160 XRAY 2.6 0.2 999.0 A 298.0 298.0 0 28 28 0 [[4, 286]] 1.0 1jst CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1JSTC P24941 1 298 298.0 ATP:300 ATPlike Active DFGin 6.225 15.1331 BLAminus -133.76, 179.75 53.92, 86.29 -100.05, 15.63 279.16, 71.07 -59.91, -21.96 in-in in 8.679 Saltbr-in 2.9469 HRD-in -76.84, -49.3 61.77, 13.04 in-in-in SNCiii in-in ActLoopNT-in 2.7007 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.31, -163.7 APE9-dihe-na 66.67, 148.27 APE8-dihe-in -72.61, 126.34 APE8-rot-in 301.65 APE67-dihe-in -51.49, -27.24 -26.21, -64.21 APE12-dist-in 13.4121 APE11-dist-in 12.7409 APE10-dist-in 6.9421 APE9-dist-in 3.2045 None TPO160 TPO160 XRAY 2.6 0.2 999.0 C 298.0 298.0 0 28 28 0 [[4, 286]] 1.0 1jst CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2CJMA P24941 1 292 298.0 ATP:1294 ATPlike Active DFGin 6.4115 15.4766 BLAminus -133.49, 174.28 59.08, 80.72 -93.05, 17.33 280.25, 71.88 -51.1, -37.87 in-in in 8.875 Saltbr-in 3.0274 HRD-in -83.77, -55.33 74.52, 15.85 in-in-in SNCiii in-in ActLoopNT-in 2.7962 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.97, -48.89 APE9-dihe-na -98.03, 148.0 APE8-dihe-in -53.4, 136.55 APE8-rot-in 296.67 APE67-dihe-in -56.28, -31.52 -52.78, -45.83 APE12-dist-in 13.3285 APE11-dist-in 10.5533 APE10-dist-in 7.1798 APE9-dist-in 3.4643 None PTR15,TPO160 PTR15,TPO160 XRAY 2.3 0.204 0.265 A 298.0 287.0 5 28 28 0 [[4, 286]] 1.0 2cjm CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2CJMC P24941 1 297 298.0 ATP:1298 ATPlike Active DFGin 6.4464 15.3889 BLAminus -136.23, -173.15 48.46, 78.84 -90.01, 21.15 280.3, 74.36 -53.78, -24.47 in-in in 8.9566 Saltbr-in 2.575 HRD-in -82.67, -49.67 67.53, 9.26 in-in-in SNCiii in-in ActLoopNT-in 2.9786 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.3, -72.35 APE9-dihe-na -81.21, 139.76 APE8-dihe-in -48.67, 128.86 APE8-rot-in 299.02 APE67-dihe-in -54.58, -22.4 -47.31, -51.92 APE12-dist-in 13.0675 APE11-dist-in 10.808 APE10-dist-in 7.0087 APE9-dist-in 3.5797 None PTR15,TPO160 PTR15,TPO160 XRAY 2.3 0.204 0.265 C 298.0 297.0 0 28 28 0 [[4, 286]] 1.0 2cjm CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1GY3A P24941 1 296 298.0 ATP:1297 ATPlike Active DFGin 6.7113 15.7388 BLAminus -148.85, -171.85 44.28, 78.14 -91.55, 12.53 280.84, 73.84 -49.56, -35.56 in-in in 8.826 Saltbr-in 2.8696 HRD-in -78.88, -56.55 74.04, 15.78 in-in-in SNCiii in-in ActLoopNT-in 3.1293 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.01, 152.98 APE9-dihe-na 75.99, 139.26 APE8-dihe-in -71.28, 139.34 APE8-rot-in 297.69 APE67-dihe-in -59.44, -30.42 -47.65, -49.93 APE12-dist-in 13.1561 APE11-dist-in 10.6778 APE10-dist-in 7.643 APE9-dist-in 3.395 None TPO160 TPO160 XRAY 2.7 0.25 0.313 A 299.0 296.0 0 28 28 0 [[4, 286]] 1.0 1gy3 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1GY3C P24941 1 296 298.0 ATP:1298 ATPlike Active DFGin 6.8235 15.3763 BLAminus -159.42, -172.39 46.56, 69.8 -88.25, 18.8 278.1, 68.22 -63.28, -3.45 in-in in 8.6103 Saltbr-in 3.3162 HRD-in -72.89, -69.46 86.12, 7.32 in-in-in SNCiii in-in ActLoopNT-in 2.7939 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.99, 145.31 APE9-dihe-na 77.28, 144.74 APE8-dihe-in -75.96, 137.92 APE8-rot-in 277.1 APE67-dihe-in -64.24, -30.46 -41.97, -49.4 APE12-dist-in 13.1946 APE11-dist-in 10.6355 APE10-dist-in 7.7718 APE9-dist-in 3.2116 None TPO160 TPO160 XRAY 2.7 0.25 0.313 C 299.0 296.0 0 28 28 0 [[4, 286]] 1.0 1gy3 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1QMZA P24941 1 296 298.0 ATP:60381 ATPlike Active DFGin 6.4238 15.17 BLAminus -146.26, -172.65 47.53, 78.45 -93.94, 24.34 280.23, 76.95 -74.2, -4.32 in-in in 8.7401 Saltbr-in 2.6634 HRD-in -79.61, -61.2 70.52, 19.43 in-in-in SNCiii in-in ActLoopNT-in 2.9813 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.31, 152.76 APE9-dihe-na 72.53, 130.75 APE8-dihe-in -60.65, 130.8 APE8-rot-in 293.88 APE67-dihe-in -60.7, -26.37 -33.48, -54.72 APE12-dist-in 13.0196 APE11-dist-in 10.0953 APE10-dist-in 7.17 APE9-dist-in 3.2347 None TPO160 TPO160 XRAY 2.2 0.22 0.28 A 299.0 296.0 0 28 28 0 [[4, 286]] 1.0 1qmz CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1QMZC P24941 1 296 298.0 ATP:60381 ATPlike Active DFGin 6.5123 15.1345 BLAminus -147.61, -169.98 41.15, 80.53 -95.52, 25.6 283.09, 73.82 -79.03, -0.31 in-in in 8.7403 Saltbr-in 2.5397 HRD-in -75.88, -57.22 71.34, 18.39 in-in-in SNCiii in-in ActLoopNT-in 2.9931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.04, 148.92 APE9-dihe-na 73.46, 130.58 APE8-dihe-in -61.75, 132.61 APE8-rot-in 296.97 APE67-dihe-in -70.09, -17.52 -37.4, -48.3 APE12-dist-in 12.9473 APE11-dist-in 10.1029 APE10-dist-in 7.1904 APE9-dist-in 3.2342 None TPO160 TPO160 XRAY 2.2 0.22 0.28 C 299.0 296.0 0 28 28 0 [[4, 286]] 1.0 1qmz CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2CCHA P24941 1 296 298.0 ATP:61297 ATPlike Active DFGin 6.6481 15.4963 BLAminus -138.14, 178.31 65.58, 62.78 -86.23, 16.74 281.6, 70.81 -63.75, -23.41 in-in in 8.7947 Saltbr-in 2.8278 HRD-in -78.21, -56.44 71.04, 15.24 in-in-in SNCiii in-in ActLoopNT-in 2.8968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.4, 152.64 APE9-dihe-na 69.68, 132.94 APE8-dihe-in -57.07, 137.05 APE8-rot-in 294.63 APE67-dihe-in -60.03, -20.02 -46.03, -52.89 APE12-dist-in 13.1982 APE11-dist-in 10.3601 APE10-dist-in 7.2078 APE9-dist-in 3.2861 None TPO160 TPO160 XRAY 1.7 0.15 0.182 A 299.0 296.0 0 28 28 0 [[4, 286]] 1.0 2cch CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2CCHC P24941 1 296 298.0 ATP:61297 ATPlike Active DFGin 6.4766 15.3817 BLAminus -137.71, -178.58 51.07, 78.61 -96.17, 22.01 279.1, 72.77 -65.43, -25.94 in-in in 8.6526 Saltbr-in 2.7189 HRD-in -81.45, -53.09 63.51, 17.55 in-in-in SNCiii in-in ActLoopNT-in 2.8858 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.56, 136.55 APE9-dihe-na 76.27, 128.23 APE8-dihe-in -59.37, 134.24 APE8-rot-in 303.33 APE67-dihe-in -63.22, -26.6 -41.45, -49.27 APE12-dist-in 12.8664 APE11-dist-in 10.056 APE10-dist-in 7.3772 APE9-dist-in 3.2603 None TPO160 TPO160 XRAY 1.7 0.15 0.182 C 299.0 296.0 0 28 28 0 [[4, 286]] 1.0 2cch CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2CCIA P24941 1 296 298.0 ATP:61297 ATPlike Active DFGin 6.4591 15.3718 BLAminus -128.71, -173.86 48.01, 81.43 -98.73, 25.24 282.02, 74.31 -66.86, -20.71 in-in in 8.9016 Saltbr-in 3.076 HRD-in -75.27, -47.91 58.22, 13.15 in-in-in SNCiii in-in ActLoopNT-in 2.892 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.39, 140.99 APE9-dihe-na 76.14, 131.3 APE8-dihe-in -63.2, 133.24 APE8-rot-in 305.53 APE67-dihe-in -53.35, -21.65 -35.23, -63.18 APE12-dist-in 12.9583 APE11-dist-in 10.3232 APE10-dist-in 7.2456 APE9-dist-in 3.2913 None TPO160 TPO160 XRAY 2.7 0.264 0.321 A 299.0 296.0 0 28 28 0 [[4, 286]] 1.0 2cci CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2CCIC P24941 1 296 298.0 ATP:61297 ATPlike Active DFGin 6.2316 15.3818 BLAminus -129.31, 167.15 64.1, 86.76 -100.18, 28.53 276.86, 72.85 -63.26, -37.36 in-in in 8.5509 Saltbr-in 2.6658 HRD-in -73.66, -47.99 63.69, 10.4 in-in-in SNCiii in-in ActLoopNT-in 3.0639 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.2, 138.6 APE9-dihe-na 71.13, 137.9 APE8-dihe-in -63.98, 129.66 APE8-rot-in 301.4 APE67-dihe-in -61.96, -9.78 -29.15, -60.17 APE12-dist-in 12.7527 APE11-dist-in 9.7665 APE10-dist-in 7.4196 APE9-dist-in 3.2337 None TPO160 TPO160 XRAY 2.7 0.264 0.321 C 299.0 296.0 0 28 28 0 [[4, 286]] 1.0 2cci CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOQA P24941 1 297 298.0 ATP:60301 ATPlike Inactive DFGin 6.6029 15.2578 BLAminus -136.2, -179.04 55.17, 77.3 -91.43, 19.33 282.26, 72.55 -64.29, -18.87 in-in in 8.7855 Saltbr-in 2.8451 HRD-in -79.78, -53.17 69.74, 9.41 in-in-out SNCiio in-out ActLoopNT-in 2.9063 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na 62.26, 128.16 APE9-dihe-na 76.05, 127.33 APE8-dihe-in -62.55, 137.94 APE8-rot-out 115.71 APE67-dihe-in -58.94, -23.33 -43.56, -48.15 APE12-dist-in 13.3614 APE11-dist-in 9.1579 APE10-dist-in 7.1767 APE9-dist-in 3.2463 None TPO160 TPO160 XRAY 2.15 0.201 0.234 A 301.0 294.0 3 28 28 0 [[4, 286]] 1.0 4eoq CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOQC P24941 1 296 298.0 ATP:60301 ATPlike Inactive DFGin 6.5834 15.2493 BLAminus -140.92, -177.14 51.0, 72.99 -85.26, 24.65 284.32, 71.69 -63.95, -27.55 in-in in 8.6489 Saltbr-in 2.7133 HRD-in -79.85, -57.3 73.26, 6.95 in-in-out SNCiio in-out ActLoopNT-in 2.9487 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -135.95, 149.43 APE9-dihe-na 70.01, 126.65 APE8-dihe-in -62.68, 144.35 APE8-rot-out 86.91 APE67-dihe-in -60.3, -23.97 -41.77, -51.35 APE12-dist-in 12.9226 APE11-dist-in 9.9884 APE10-dist-in 7.0552 APE9-dist-in 3.1801 None TPO160 TPO160 XRAY 2.15 0.201 0.234 C 301.0 272.0 24 28 28 0 [[4, 286]] 1.0 4eoq CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOJA P24941 1 298 298.0 ATP:60301 ATPlike Inactive DFGin 6.6711 15.3765 BLAminus -134.08, 177.58 53.89, 78.08 -94.34, 17.78 277.91, 75.6 -65.2, -18.6 in-in in 8.6422 Saltbr-in 2.9234 HRD-in -77.88, -54.19 68.96, 13.72 in-in-out SNCiio in-out ActLoopNT-in 2.9516 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -80.75, 158.76 APE9-dihe-na 76.84, 131.84 APE8-dihe-in -62.19, 141.78 APE8-rot-out 119.83 APE67-dihe-in -58.91, -24.4 -48.51, -47.68 APE12-dist-in 13.3089 APE11-dist-in 9.1489 APE10-dist-in 7.3326 APE9-dist-in 3.2138 H84S,Q85M,K89D TPO160 TPO160 XRAY 1.65 0.197 0.215 A 302.0 294.0 4 28 28 0 [[4, 286]] 1.0 4eoj CMGC_CDK2_HUMAN CMGC 2.1e-89 306.1 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOJC P24941 1 296 298.0 ATP:60301 ATPlike Inactive DFGin 6.6044 15.375 BLAminus -136.46, -177.75 51.71, 75.47 -89.77, 20.18 280.05, 73.98 -59.21, -28.77 in-in in 8.5899 Saltbr-in 2.6303 HRD-in -79.08, -54.75 70.82, 10.21 in-in-out SNCiio in-out ActLoopNT-in 2.9181 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.67, 155.4 APE9-dihe-na 67.15, 126.49 APE8-dihe-in -61.14, 141.64 APE8-rot-out 49.99 APE67-dihe-in -62.84, -21.66 -42.97, -49.5 APE12-dist-in 12.8966 APE11-dist-in 9.8259 APE10-dist-in 6.8336 APE9-dist-in 3.1843 H84S,Q85M,K89D TPO160 TPO160 XRAY 1.65 0.197 0.215 C 302.0 279.0 17 28 28 0 [[4, 286]] 1.0 4eoj CMGC_CDK2_HUMAN CMGC 2.1e-89 306.1 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1HCKA P24941 1 298 298.0 ATP:400 ATPlike Inactive DFGin 10.5207 18.374 BLBtrans -101.64, 156.72 59.01, 28.24 -65.02, 120.2 217.92, 114.75 87.03, -4.22 out-out out 14.8863 Saltbr-out 16.6024 HRD-in -89.06, -54.55 70.31, -1.71 out-out-out SNCooo out-out ActLoopNT-out 5.7676 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -59.61, 130.9 APE9-dihe-na -79.22, 142.0 APE8-dihe-in -76.12, 133.01 APE8-rot-out 180.79 APE67-dihe-in -48.4, -27.96 -101.36, -7.62 APE12-dist-out 20.0772 APE11-dist-out 17.5988 APE10-dist-out 19.4709 APE9-dist-out 11.0313 None None None XRAY 1.9 0.185 0.272 A 298.0 294.0 4 28 28 0 [[4, 286]] 1.0 1hck CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 8FP5A P24941 2 298 298.0 ATP:302 ATPlike Inactive DFGin 10.3755 18.3199 BLBtrans -107.51, 151.36 65.27, 30.62 -67.28, 128.54 213.84, 133.39 81.57, 1.02 out-out out 15.7956 Saltbr-out 15.8731 HRD-in -85.24, -57.92 82.57, -13.18 out-out-out SNCooo out-out ActLoopNT-out 5.8933 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -82.36, 136.98 APE9-dihe-na -71.53, 131.08 APE8-dihe-in -77.4, 124.67 APE8-rot-in 308.71 APE67-dihe-in -62.7, -24.4 -97.59, -2.61 APE12-dist-out 20.412 APE11-dist-out 17.3616 APE10-dist-out 19.0753 APE9-dist-out 10.9192 None None None XRAY 1.7 0.196 0.23 A 298.0 288.0 9 28 28 0 [[4, 286]] 1.0 8fp5 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1B38A P24941 1 298 298.0 ATP:60381 ATPlike Inactive DFGin 10.1969 18.3025 BLBtrans -95.65, 156.45 60.68, 25.9 -58.03, 132.69 221.26, 95.46 85.91, -14.49 out-out out 15.1536 Saltbr-out 16.0636 HRD-in -76.6, -58.97 89.85, -20.78 out-out-out SNCooo out-out ActLoopNT-out 6.2075 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -77.95, 142.89 APE9-dihe-na -75.18, 129.36 APE8-dihe-in -71.98, 129.31 APE8-rot-out 193.64 APE67-dihe-in -51.99, -31.61 -101.67, -5.99 APE12-dist-out 19.5535 APE11-dist-out 17.4582 APE10-dist-out 18.6728 APE9-dist-out 10.5678 None None None XRAY 2.0 0.18 0.25 A 299.0 290.0 8 28 28 0 [[4, 286]] 1.0 1b38 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1B39A P24941 1 298 298.0 ATP:60381 ATPlike Inactive DFGin 10.5338 18.343 BLBtrans -101.01, 147.7 73.19, 23.92 -63.93, 137.58 224.37, 103.76 85.74, -27.62 out-out out 15.4122 Saltbr-out 16.0286 HRD-in -84.44, -53.29 77.56, -15.37 out-out-out SNCooo out-out ActLoopNT-out 5.8425 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -101.65, 122.32 APE9-dihe-na -57.75, 145.92 APE8-dihe-in -67.9, 142.03 APE8-rot-in 290.02 APE67-dihe-in -56.66, -23.98 -105.17, -10.65 APE12-dist-out 20.4627 APE11-dist-out 17.1833 APE10-dist-out 18.3127 APE9-dist-out 9.9797 None None None XRAY 2.1 0.2 0.27 A 299.0 290.0 8 28 28 0 [[4, 286]] 1.0 1b39 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK7 CDK7_HUMAN 1UA2A P50613 13 311 346.0 ATP:381 ATPlike Inactive DFGin 3.8381 15.0736 None -72.36, 176.54 -63.29, 129.93 -58.5, 61.34 34.11, 88.78 62.95, -115.18 out-out out 13.0144 Saltbr-out 13.6332 HRD-out -71.94, 127.86 -111.75, 17.16 out-out-out SNCooo out-out ActLoopNT-out 10.7811 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -60.17, 155.77 APE9-dihe-na -94.04, -36.01 APE8-dihe-out 80.52, 83.34 APE8-rot-in 310.15 APE67-dihe-in -70.12, 0.07 -111.89, 13.44 APE12-dist-out 21.6082 APE11-dist-out 18.7453 APE10-dist-out 20.4575 APE9-dist-out 13.0189 None TPO170 TPO170 XRAY 3.02 0.217 0.288 A 346.0 287.0 13 28 28 0 [[12, 295]] 1.0 1ua2 CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 1UA2B P50613 13 311 346.0 ATP:382 ATPlike Inactive DFGin 4.0749 14.4826 None -83.42, -165.13 -43.25, 135.34 -79.47, 27.14 49.47, 35.58 128.26, -117.59 out-out out 13.2082 Saltbr-out 11.1817 HRD-out -90.35, 54.77 -58.64, -3.2 out-out-out SNCooo out-out ActLoopNT-out 10.7547 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -59.37, 128.97 APE9-dihe-na -70.17, -103.62 APE8-dihe-out 114.41, 132.59 APE8-rot-out 86.06 APE67-dihe-in -64.71, -6.03 -138.86, 19.47 APE12-dist-out 21.3562 APE11-dist-out 17.9388 APE10-dist-out 20.1165 APE9-dist-out 13.1186 None TPO170 TPO170 XRAY 3.02 0.217 0.288 B 346.0 287.0 13 28 28 0 [[12, 295]] 1.0 1ua2 CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 1UA2C P50613 13 311 346.0 ATP:383 ATPlike Inactive DFGin 4.3773 15.832 None -69.53, 164.86 -53.4, 113.84 -55.09, 81.41 35.63, 74.81 38.07, -90.08 out-out out 14.2914 Saltbr-out 13.3504 HRD-out -90.81, 75.3 -67.23, 24.34 out-out-out SNCooo out-out ActLoopNT-out 10.7246 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -61.3, 146.02 APE9-dihe-na -103.14, 168.98 APE8-dihe-in -149.98, 115.15 APE8-rot-in 317.59 APE67-dihe-in -70.34, -0.48 -115.08, 9.43 APE12-dist-out 21.9947 APE11-dist-out 19.6363 APE10-dist-out 20.1195 APE9-dist-out 12.6188 None TPO170 TPO170 XRAY 3.02 0.217 0.288 C 346.0 287.0 13 28 28 0 [[12, 295]] 1.0 1ua2 CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 1UA2D P50613 13 311 346.0 ATP:384 ATPlike Inactive DFGin 3.9714 15.4823 None -66.13, 178.54 -66.01, 128.6 -62.88, 66.21 38.44, 67.87 63.18, -97.8 out-out out 13.2417 Saltbr-out 13.5751 HRD-out -80.45, 94.07 -71.75, -5.97 out-out-out SNCooo out-out ActLoopNT-out 10.8955 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.63, 129.76 APE9-dihe-na -71.09, 152.84 APE8-dihe-in -147.91, 130.69 APE8-rot-out 68.98 APE67-dihe-in -88.14, 9.58 -128.15, 23.18 APE12-dist-out 22.1448 APE11-dist-out 18.8445 APE10-dist-out 20.0096 APE9-dist-out 12.6573 None TPO170 TPO170 XRAY 3.02 0.217 0.288 D 346.0 287.0 13 28 28 0 [[12, 295]] 1.0 1ua2 CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK9 CDK9_HUMAN 3BLQA P50750 7 325 372.0 ATP:332 ATPlike Active DFGin 6.9827 15.2352 BLAminus -137.33, 167.71 61.72, 82.78 -101.54, 27.58 292.13, 71.79 -68.35, -20.47 in-in in 9.5144 Saltbr-in 3.2566 HRD-in -70.77, -57.41 73.91, 6.35 in-in-in SNCiii in-in ActLoopNT-in 2.8505 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.28, 155.2 APE9-dihe-na 75.14, 129.25 APE8-dihe-in -51.14, 147.2 APE8-rot-in 304.68 APE67-dihe-in -62.86, -25.73 -50.2, -49.1 APE12-dist-in 13.0281 APE11-dist-in 11.0296 APE10-dist-in 6.8964 APE9-dist-in 3.1544 None TPO186 TPO186 XRAY 2.9 0.174 0.234 A 331.0 296.0 23 32 25 7 [[19, 315]] 1.0 3blq CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CMGC CSNK2A1 CSK21_HUMAN 5CU6A P68400 3 329 391.0 ATP:401 ATPlike Active DFGin 7.3735 16.3007 BLAminus -117.96, -176.97 52.74, 80.35 -94.88, 19.06 296.35, 83.62 -69.11, -18.98 in-in in 9.2959 Saltbr-in 2.9965 HRD-in -73.54, -48.21 69.17, 10.55 in-in-in SNCiii in-in ActLoopNT-in 2.8943 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.92, 173.11 APE9-dihe-na 58.61, 170.65 APE8-dihe-in -94.81, 150.1 APE8-rot-in 295.17 APE67-dihe-in -71.66, -13.32 -37.08, -56.84 APE12-dist-in 12.6525 APE11-dist-in 10.3342 APE10-dist-in 6.1816 APE9-dist-in 3.1457 R21S,K74A,K75A,K76A None None XRAY 1.36 0.188 0.209 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 5cu6 CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZYDA P68400 3 329 391.0 ATP:403,KD6:404 ATPlike,Allosteric Active DFGin 7.3287 16.2144 BLAminus -118.97, -177.69 55.36, 75.35 -91.38, 15.36 296.7, 79.46 -65.95, -20.35 in-in in 9.2711 Saltbr-in 2.8643 HRD-in -76.19, -47.14 68.74, 13.25 in-in-in SNCiii in-in ActLoopNT-in 2.8609 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.11, 172.03 APE9-dihe-na 59.78, 163.78 APE8-dihe-in -88.12, 149.21 APE8-rot-in 297.74 APE67-dihe-in -70.35, -14.8 -37.52, -55.55 APE12-dist-in 12.6652 APE11-dist-in 10.1915 APE10-dist-in 6.197 APE9-dist-in 3.1923 R21S,K74A,K75A,K76A None None XRAY 1.404 0.199 0.214 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 7zyd CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZYRA P68400 3 329 391.0 ATP:401,KF6:406 ATPlike,Allosteric Active DFGin 7.384 16.3356 BLAminus -115.5, -176.17 54.52, 75.81 -90.94, 15.84 295.5, 83.13 -67.01, -21.05 in-in in 9.3003 Saltbr-in 3.0667 HRD-in -73.81, -46.94 67.44, 10.6 in-in-in SNCiii in-in ActLoopNT-in 2.9615 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.26, 163.7 APE9-dihe-na 66.11, 155.14 APE8-dihe-in -79.05, 149.29 APE8-rot-in 297.87 APE67-dihe-in -66.86, -16.16 -37.19, -56.72 APE12-dist-in 12.6488 APE11-dist-in 10.2716 APE10-dist-in 6.0959 APE9-dist-in 3.2817 R21S,K74A,K75A,K76A None None XRAY 1.85 0.17 0.209 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 7zyr CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 8AECA P68400 3 329 391.0 ATP:401,LW3:404 ATPlike,Allosteric Inactive DFGin 7.1758 16.144 BLAminus -118.04, -179.83 50.85, 85.39 -95.14, 14.95 295.73, 81.33 -66.57, -20.11 in-in in 9.2626 Saltbr-in 2.8283 HRD-in -74.16, -49.17 69.92, 11.72 in-in-out SNCiio in-out ActLoopNT-in 2.8412 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.03, 173.8 APE9-dihe-na 56.87, 164.78 APE8-dihe-in -92.58, 150.13 APE8-rot-out 58.14 APE67-dihe-in -68.24, -15.5 -36.53, -56.67 APE12-dist-in 12.6341 APE11-dist-in 10.2886 APE10-dist-in 6.1789 APE9-dist-in 3.1133 R21S,K74A,K75A,K76A None None XRAY 1.09 0.196 0.209 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 8aec CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OSPA P68400 3 329 391.0 ATP:401,A9W:406 ATPlike,Allosteric Active DFGin 7.4481 16.2595 BLAminus -112.91, -173.94 47.41, 80.27 -93.43, 19.44 295.5, 80.71 -64.79, -26.04 in-in in 9.236 Saltbr-in 2.8108 HRD-in -68.59, -50.2 68.38, 8.36 in-in-in SNCiii in-in ActLoopNT-in 2.9607 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.65, 166.65 APE9-dihe-na 64.03, 159.2 APE8-dihe-in -80.26, 148.93 APE8-rot-in 296.57 APE67-dihe-in -70.89, -16.0 -37.06, -53.51 APE12-dist-in 12.7116 APE11-dist-in 10.3653 APE10-dist-in 6.1352 APE9-dist-in 3.3318 R21S,K74A,K75A,K76A None None XRAY 1.91 0.174 0.213 A 342.0 327.0 0 27 27 0 [[39, 324]] 1.0 5osp CMGC_CSNK2A1_HUMAN CMGC 9.4e-69 237.9 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OSRA P68400 3 329 391.0 ATP:403,AFK:404 ATPlike,Allosteric Active DFGin 7.3901 16.2349 BLAminus -115.2, -175.48 53.01, 75.53 -91.02, 17.2 296.18, 83.93 -66.77, -22.5 in-in in 9.1703 Saltbr-in 2.886 HRD-in -76.06, -46.71 67.27, 11.5 in-in-in SNCiii in-in ActLoopNT-in 2.9019 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.95, 170.87 APE9-dihe-na 60.56, 162.64 APE8-dihe-in -87.43, 145.48 APE8-rot-in 300.92 APE67-dihe-in -69.88, -13.97 -33.79, -56.46 APE12-dist-in 12.7267 APE11-dist-in 10.3646 APE10-dist-in 6.1844 APE9-dist-in 3.1669 R21S,K74A,K75A,K76A None None XRAY 1.57 0.177 0.209 A 342.0 327.0 0 27 27 0 [[39, 324]] 1.0 5osr CMGC_CSNK2A1_HUMAN CMGC 9.4e-69 237.9 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZY2A P68400 3 329 391.0 ATP:401,H4N:404,H4N:405 ATPlike,Allosteric,Allosteric Active DFGin 7.4672 16.2804 BLAminus -114.82, -177.5 55.14, 73.38 -87.5, 13.22 295.06, 80.66 -60.96, -25.13 in-in in 9.251 Saltbr-in 2.9307 HRD-in -72.23, -48.39 67.99, 7.65 in-in-in SNCiii in-in ActLoopNT-in 2.9304 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.44, 169.73 APE9-dihe-na 59.19, 155.39 APE8-dihe-in -76.55, 147.29 APE8-rot-in 280.93 APE67-dihe-in -68.75, -13.44 -39.25, -54.49 APE12-dist-in 12.6992 APE11-dist-in 10.3603 APE10-dist-in 6.1638 APE9-dist-in 3.2683 R21S,K74A,K75A,K76A None None XRAY 1.51 0.189 0.21 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 7zy2 CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZYOA P68400 3 329 391.0 ATP:401,KEX:404,KEX:405 ATPlike,Allosteric,Allosteric Active DFGin 7.5021 16.3978 BLAminus -113.84, -177.01 53.93, 77.01 -92.97, 16.97 297.5, 80.44 -65.6, -20.61 in-in in 9.1968 Saltbr-in 2.9301 HRD-in -77.03, -47.55 70.73, 4.92 in-in-in SNCiii in-in ActLoopNT-in 2.8853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.4, 169.84 APE9-dihe-na 59.33, 166.07 APE8-dihe-in -87.44, 145.03 APE8-rot-in 291.2 APE67-dihe-in -67.16, -16.67 -36.15, -55.82 APE12-dist-in 12.7559 APE11-dist-in 10.6015 APE10-dist-in 6.1939 APE9-dist-in 3.2206 R21S,K74A,K75A,K76A None None XRAY 1.58 0.176 0.204 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 7zyo CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OS7B P68400 3 327 391.0 A8Q:402,ATP:403 Allosteric,ATPlike Active DFGin 7.4028 16.2864 BLAminus -113.36, -175.81 49.81, 80.69 -97.06, 16.82 294.27, 80.08 -65.25, -22.08 in-in in 9.4111 Saltbr-in 2.7974 HRD-in -70.47, -48.19 65.29, 14.71 in-in-in SNCiii in-in ActLoopNT-in 2.8567 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.46, 173.88 APE9-dihe-na 61.83, 168.57 APE8-dihe-in -97.24, 140.84 APE8-rot-in 297.98 APE67-dihe-in -62.16, -22.89 -29.44, -59.48 APE12-dist-in 12.6394 APE11-dist-in 10.3708 APE10-dist-in 6.0285 APE9-dist-in 3.1105 R21S None None XRAY 1.66 0.222 0.247 B 352.0 325.0 0 27 27 0 [[39, 324]] 1.0 5os7 CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6GMDA P68400 3 327 391.0 A8Q:402,ATP:403 Allosteric,ATPlike Active DFGin 7.4028 16.2864 BLAminus -113.36, -175.81 49.81, 80.69 -97.06, 16.82 294.27, 80.08 -65.25, -22.08 in-in in 9.4111 Saltbr-in 2.7974 HRD-in -70.47, -48.19 65.29, 14.71 in-in-in SNCiii in-in ActLoopNT-in 2.8567 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.46, 173.88 APE9-dihe-na 61.83, 168.57 APE8-dihe-in -97.24, 140.84 APE8-rot-in 297.98 APE67-dihe-in -62.16, -21.58 -29.44, -59.48 APE12-dist-in 12.6394 APE11-dist-in 10.3708 APE10-dist-in 6.0285 APE9-dist-in 3.1105 R21S None None XRAY 1.66 0.222 0.247 A 352.0 325.0 0 27 27 0 [[39, 324]] 1.0 6gmd CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5CVFA P68400 3 329 391.0 54Z:401,ATP:402 Allosteric,ATPlike Active DFGin 7.4695 16.2682 BLAminus -117.2, -174.73 54.63, 71.77 -90.8, 22.72 298.48, 81.13 -69.82, -23.93 in-in in 9.2813 Saltbr-in 2.8202 HRD-in -73.12, -49.94 68.07, 7.39 in-in-in SNCiii in-in ActLoopNT-in 2.9183 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.49, 166.86 APE9-dihe-na 61.99, 156.53 APE8-dihe-in -74.21, 147.85 APE8-rot-in 294.94 APE67-dihe-in -65.44, -19.86 -39.38, -55.54 APE12-dist-in 12.6662 APE11-dist-in 10.3039 APE10-dist-in 6.173 APE9-dist-in 3.2513 R21S,K74A,K75A,K76A None None XRAY 1.63 0.201 0.209 A 328.0 325.0 2 27 27 0 [[39, 324]] 1.0 5cvf CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6FVFA P68400 3 329 391.0 503:401,ATP:402 Allosteric,ATPlike Inactive DFGin 7.4582 15.9956 BLAminus -117.08, -172.6 51.64, 74.63 -91.13, 21.7 296.66, 78.77 -67.99, -24.04 in-in in 9.3699 Saltbr-in 2.8041 HRD-in -73.47, -46.21 64.83, 11.56 in-in-out SNCiio in-out ActLoopNT-in 2.8599 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.11, 170.35 APE9-dihe-na 60.67, 163.08 APE8-dihe-in -84.61, 146.09 APE8-rot-out 196.52 APE67-dihe-in -71.22, -11.21 -34.5, -54.96 APE12-dist-in 12.7452 APE11-dist-in 10.4414 APE10-dist-in 6.2805 APE9-dist-in 3.1313 R21S,K74A,K75A,K76A None None XRAY 1.47 0.201 0.222 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 6fvf CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6FVGA P68400 3 329 391.0 E8K:401,ATP:402 Allosteric,ATPlike Inactive DFGin 7.5637 16.2487 BLAminus -114.12, -177.27 49.95, 79.39 -92.46, 19.09 295.44, 80.72 -62.08, -29.09 in-in in 9.4713 Saltbr-in 2.8666 HRD-in -71.26, -47.89 65.91, 11.22 in-in-out SNCiio in-out ActLoopNT-in 2.9197 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -131.37, 168.11 APE9-dihe-na 62.71, 167.0 APE8-dihe-in -87.82, 142.1 APE8-rot-out 201.01 APE67-dihe-in -70.04, -16.46 -32.6, -53.52 APE12-dist-in 12.9025 APE11-dist-in 10.5439 APE10-dist-in 6.3447 APE9-dist-in 3.2082 R21S,K74A,K75A,K76A None None XRAY 1.6 0.208 0.229 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 6fvg CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 8AEKA P68400 3 329 391.0 LVL:401,ATP:402 Allosteric,ATPlike Active DFGin 7.3593 16.189 BLAminus -116.05, -177.84 59.67, 69.99 -88.27, 14.27 295.52, 85.07 -64.38, -21.31 in-in in 9.2052 Saltbr-in 2.8162 HRD-in -74.44, -47.13 67.98, 9.84 in-in-in SNCiii in-in ActLoopNT-in 2.9283 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.41, 169.56 APE9-dihe-na 60.21, 157.69 APE8-dihe-in -79.56, 148.43 APE8-rot-in 292.83 APE67-dihe-in -70.07, -13.69 -40.23, -52.63 APE12-dist-in 12.6377 APE11-dist-in 10.3195 APE10-dist-in 6.099 APE9-dist-in 3.2103 R21S,K74A,K75A,K76A None None XRAY 1.65 0.173 0.198 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 8aek CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 8AEMA P68400 3 329 391.0 LVF:407,ATP:408 Allosteric,ATPlike Active DFGin 7.3989 16.1874 BLAminus -114.2, -178.47 56.21, 75.05 -90.39, 15.9 296.69, 81.8 -66.43, -20.83 in-in in 9.1318 Saltbr-in 2.816 HRD-in -72.91, -51.16 68.69, 11.11 in-in-in SNCiii in-in ActLoopNT-in 2.9049 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.83, 169.06 APE9-dihe-na 58.87, 157.76 APE8-dihe-in -77.1, 150.54 APE8-rot-in 294.73 APE67-dihe-in -68.78, -13.55 -40.19, -53.95 APE12-dist-in 12.7442 APE11-dist-in 10.4167 APE10-dist-in 6.256 APE9-dist-in 3.2152 R21S,K74A,K75A,K76A None None XRAY 1.6 0.19 0.212 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 8aem CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5CSHA P68400 4 327 391.0 54E:401,54E:402,ATP:403 Allosteric,Allosteric,ATPlike Active DFGin 7.4358 16.4754 BLAminus -114.33, -175.52 50.17, 77.83 -91.69, 16.93 295.31, 78.96 -64.52, -21.3 in-in in 9.6059 Saltbr-in 2.7982 HRD-in -72.7, -45.69 67.95, 9.72 in-in-in SNCiii in-in ActLoopNT-in 2.9615 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.3, 172.6 APE9-dihe-na 60.22, 166.59 APE8-dihe-in -92.85, 140.16 APE8-rot-in 301.7 APE67-dihe-in -64.39, -20.56 -30.14, -59.7 APE12-dist-in 12.5077 APE11-dist-in 10.2856 APE10-dist-in 6.0147 APE9-dist-in 3.087 R21S None None XRAY 1.59 0.194 0.207 A 352.0 324.0 0 27 27 0 [[39, 324]] 1.0 5csh CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5CSHB P68400 2 328 391.0 54E:403,54E:404,ATP:405 Allosteric,Allosteric,ATPlike Active DFGin 7.4434 16.2929 BLAminus -115.21, -175.71 50.61, 77.51 -92.19, 18.86 294.88, 77.24 -65.62, -21.94 in-in in 9.3656 Saltbr-in 2.7742 HRD-in -75.48, -46.24 69.71, 9.97 in-in-in SNCiii in-in ActLoopNT-in 2.9888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.44, 174.47 APE9-dihe-na 60.65, 166.44 APE8-dihe-in -96.7, 141.75 APE8-rot-in 305.79 APE67-dihe-in -65.63, -20.28 -30.96, -58.74 APE12-dist-in 12.5841 APE11-dist-in 10.4239 APE10-dist-in 6.0709 APE9-dist-in 3.1244 R21S None None XRAY 1.59 0.194 0.207 B 352.0 323.0 4 27 27 0 [[39, 324]] 1.0 5csh CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OS7A P68400 3 328 391.0 A8Q:404,A8Q:405,ATP:406 Allosteric,Allosteric,ATPlike Active DFGin 7.4641 16.0887 BLAminus -111.7, -175.06 51.27, 78.03 -95.04, 15.76 293.36, 80.0 -65.49, -19.43 in-in in 9.2077 Saltbr-in 2.7576 HRD-in -69.55, -50.38 66.74, 15.37 in-in-in SNCiii in-in ActLoopNT-in 2.8784 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.67, 175.58 APE9-dihe-na 57.11, 170.24 APE8-dihe-in -96.94, 142.73 APE8-rot-in 298.08 APE67-dihe-in -63.57, -23.25 -31.45, -59.13 APE12-dist-in 12.6625 APE11-dist-in 10.3794 APE10-dist-in 6.1745 APE9-dist-in 3.1323 R21S None None XRAY 1.66 0.222 0.247 A 352.0 326.0 0 27 27 0 [[39, 324]] 1.0 5os7 CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6GMDB P68400 3 328 391.0 A8Q:404,A8Q:405,ATP:406 Allosteric,Allosteric,ATPlike Active DFGin 7.4641 16.0887 BLAminus -111.7, -175.06 51.27, 78.03 -95.04, 15.76 293.36, 80.0 -65.49, -19.43 in-in in 9.2077 Saltbr-in 2.7576 HRD-in -69.55, -50.38 66.74, 15.37 in-in-in SNCiii in-in ActLoopNT-in 2.8784 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.67, 175.58 APE9-dihe-na 57.11, 170.24 APE8-dihe-in -96.94, 142.73 APE8-rot-in 298.08 APE67-dihe-in -63.57, -23.25 -31.45, -59.13 APE12-dist-in 12.6625 APE11-dist-in 10.3794 APE10-dist-in 6.1745 APE9-dist-in 3.1323 R21S None None XRAY 1.66 0.222 0.247 B 352.0 326.0 0 27 27 0 [[39, 324]] 1.0 6gmd CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OS8A P68400 3 329 391.0 J27:404,J27:405,J27:406,ATP:407 Allosteric,Allosteric,Allosteric,ATPlike Active DFGin 7.4504 16.1456 BLAminus -116.36, -176.24 53.52, 76.44 -92.27, 17.36 295.25, 83.47 -66.45, -20.94 in-in in 9.2323 Saltbr-in 2.7892 HRD-in -76.31, -47.96 70.56, 8.8 in-in-in SNCiii in-in ActLoopNT-in 2.9016 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.3, 166.93 APE9-dihe-na 62.26, 151.31 APE8-dihe-in -76.68, 145.67 APE8-rot-in 296.22 APE67-dihe-in -69.08, -13.55 -36.03, -55.39 APE12-dist-in 12.6668 APE11-dist-in 10.3086 APE10-dist-in 6.187 APE9-dist-in 3.3128 R21S,K74A,K75A,K76A None None XRAY 1.55 0.178 0.201 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 5os8 CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OTRA P68400 3 329 391.0 AU8:403,AU8:404,AU8:405,ATP:406 Allosteric,Allosteric,Allosteric,ATPlike Active DFGin 7.4677 16.2824 BLAminus -118.34, -175.14 53.67, 73.1 -89.26, 15.26 295.08, 81.83 -61.86, -25.81 in-in in 9.3647 Saltbr-in 2.9513 HRD-in -75.87, -45.88 70.89, 5.51 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.59, 162.52 APE9-dihe-na 63.44, 152.89 APE8-dihe-in -75.69, 144.57 APE8-rot-in 311.11 APE67-dihe-in -70.25, -15.02 -34.48, -55.38 APE12-dist-in 12.8086 APE11-dist-in 10.5696 APE10-dist-in 6.3392 APE9-dist-in 3.6067 R21S,K74A,K75A,K76A None None XRAY 1.52 0.18 0.202 A 342.0 327.0 0 27 27 0 [[39, 324]] 1.0 5otr CMGC_CSNK2A1_HUMAN CMGC 9.4e-69 237.9 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
OTHER TTK TTK_HUMAN 3HMNA P33981 516 794 857.0 ATP:1 ATPlike Inactive DFGin 3.9993 14.9908 ABAminus -98.05, -9.81 -153.31, 160.67 -110.5, 6.35 307.22, 150.55 69.66, 19.48 out-out out 10.962 Saltbr-out 6.5276 HRD-in -68.45, -50.57 72.29, 2.18 out-out-out SNCooo out-out ActLoopNT-out 11.6458 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 102.39 APE9-dihe-na -78.34, -151.63 APE8-dihe-in -168.7, 144.18 APE8-rot-in 299.37 APE67-dihe-in -66.82, -19.22 -122.77, 14.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.6219 APE9-dist-out 12.1907 None None None XRAY 2.7 0.223 0.265 A 342.0 255.0 24 30 18 12 [[525, 791]] 1.0 3hmn OTHER_TTK_HUMAN CAMK 1.1e-53 188.1 1.0 256.0 256.0 663 664 665 667 669 553 571 575 644 646 645 647.0 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
RGC NPR1 ANPRA_HUMAN 9BCOA P16066 498 1053 1061.0 ATP:61101 ATPlike Pseudo DFGin 6.5001 14.8279 BLBplus -89.25, -164.06 42.72, 55.71 -135.24, 156.32 73.6, 95.91 78.22, -166.07 out-none out 16.9277 Saltbr-none 999.0 HRD-out -74.2, 156.17 -59.96, -57.76 none-out-out SNCnoo out-out ActLoopNT-out 12.0137 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -68.12, -1.53 APE9-dihe-na -60.93, -51.9 APE8-dihe-in -129.45, 85.23 APE8-rot-none 999.0 APE67-dihe-in -58.29, -38.75 -145.34, 13.28 APE12-dist-out 23.5741 APE11-dist-out 20.4302 APE10-dist-out 24.5499 APE9-dist-out 15.8581 None None None EM 4.4 999.0 999.0 A 1040.0 521.0 21 28 28 0 [[539, 803]] 1.0 9bco RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6.0 265.0 260.0 677 678 679 681 683 567 583 587 657 659 658 660.0 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCOB P16066 501 1053 1061.0 ATP:61101 ATPlike Pseudo DFGin 6.0349 14.0501 BLBplus -88.95, 166.99 56.44, 21.66 -61.11, 145.38 64.96, 87.18 86.53, -116.67 out-none out 15.4543 Saltbr-none 999.0 HRD-in -114.17, -53.78 98.92, -43.57 none-out-out SNCnoo out-out ActLoopNT-out 9.4468 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_oooo APE10-dihe-na -52.94, -51.71 APE9-dihe-na -111.55, -27.36 APE8-dihe-out -110.69, 11.24 APE8-rot-none 999.0 APE67-dihe-in -47.42, -35.74 -121.93, -1.95 APE12-dist-out 18.2038 APE11-dist-out 21.2106 APE10-dist-out 24.218 APE9-dist-out 14.7064 None None None EM 4.4 999.0 999.0 B 1040.0 517.0 22 28 28 0 [[539, 803]] 1.0 9bco RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6.0 265.0 260.0 677 678 679 681 683 567 583 587 657 659 658 660.0 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCPA P16066 505 842 1061.0 ATP:61101 ATPlike Pseudo DFGin 5.2758 13.4991 BLBplus -119.01, 147.56 55.81, 47.24 -98.35, -175.13 72.56, 101.5 63.71, -113.08 out-none out 15.017 Saltbr-none 999.0 HRD-in -101.28, -53.45 85.86, -1.89 none-out-out SNCnoo out-out ActLoopNT-out 10.0607 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -56.32, -46.22 APE9-dihe-na -56.3, -35.86 APE8-dihe-out -106.06, -11.55 APE8-rot-na 74.77 APE67-dihe-in -55.12, -26.01 -77.38, -2.19 APE12-dist-out 20.6504 APE11-dist-out 18.4713 APE10-dist-out 23.005 APE9-dist-out 14.3286 None None None EM 4.1 999.0 999.0 A 1040.0 314.0 21 28 28 0 [[539, 803]] 1.0 9bcp RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6.0 265.0 260.0 677 678 679 681 683 567 583 587 657 659 658 660.0 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCPB P16066 503 841 1061.0 ATP:61101 ATPlike Pseudo DFGin 5.3555 16.7605 BLBtrans -138.66, -167.01 55.46, 41.07 -76.35, 89.03 193.7, 109.94 60.64, -128.0 out-none out 16.6488 Saltbr-none 999.0 HRD-out -58.73, 127.47 -87.85, -41.33 none-out-out SNCnoo out-out ActLoopNT-out 12.1834 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na -63.64, -13.04 APE9-dihe-na -73.26, -45.78 APE8-dihe-out -94.47, 23.47 APE8-rot-na 181.32 APE67-dihe-out -126.85, -50.61 -149.46, 92.68 APE12-dist-out 22.3611 APE11-dist-out 19.6779 APE10-dist-out 23.708 APE9-dist-out 15.4009 None None None EM 4.1 999.0 999.0 B 1040.0 304.0 21 28 28 0 [[539, 803]] 1.0 9bcp RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6.0 265.0 260.0 677 678 679 681 683 567 583 587 657 659 658 660.0 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCSA P16066 503 1055 1061.0 ATP:61100 ATPlike Pseudo DFGin 7.6937 15.7366 None -74.51, -65.19 38.98, 36.73 -149.34, 137.28 313.08, 80.76 -109.19, -24.55 out-none out 17.3363 Saltbr-none 999.0 HRD-in -67.46, -13.34 80.4, -46.04 none-out-out SNCnoo out-out ActLoopNT-out 11.4528 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -59.39, -44.12 APE9-dihe-na -70.77, -47.95 APE8-dihe-out -62.03, -25.18 APE8-rot-na 74.24 APE67-dihe-in -57.49, -15.22 -74.7, -41.95 APE12-dist-out 24.0207 APE11-dist-out 19.7602 APE10-dist-out 23.1609 APE9-dist-out 13.3465 None None None EM 4.4 999.0 999.0 A 1040.0 515.0 23 28 28 0 [[539, 803]] 1.0 9bcs RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6.0 265.0 260.0 677 678 679 681 683 567 583 587 657 659 658 660.0 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCSB P16066 505 1055 1061.0 ATP:61100 ATPlike Pseudo None 999.0 999.0 None -84.33, 145.87 61.52, 18.75 -86.58, 62.78 999.0, 999.0 166.38, -163.08 out-none out 16.2736 Saltbr-none 999.0 HRD-in -63.93, -40.93 80.49, -6.63 none-out-out SNCnoo out-out ActLoopNT-out 11.2318 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_oooo APE10-dihe-na -65.87, -23.07 APE9-dihe-na -84.75, -47.21 APE8-dihe-out -94.13, -13.59 APE8-rot-none 999.0 APE67-dihe-in -66.6, -21.85 -106.41, 28.83 APE12-dist-out 21.8814 APE11-dist-out 20.4057 APE10-dist-out 24.7198 APE9-dist-out 14.2606 None None None EM 4.4 999.0 999.0 B 1040.0 523.0 25 28 28 0 [[539, 803]] 1.0 9bcs RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6.0 265.0 260.0 677 678 679 681 683 567 583 587 657 659 658 660.0 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
STE MAP2K1 MP2K1_HUMAN 4AN3A Q02750 61 381 393.0 ATP:61383,5Y0:61384 ATPlike,Type3 Inactive DFGin 6.3723 14.221 BLBplus -129.12, 178.33 68.61, 30.98 -85.55, 168.03 44.05, 86.92 -96.2, 75.38 out-out out 15.6935 Saltbr-out 15.4163 HRD-in -67.68, -62.51 95.67, -17.38 out-out-out SNCooo out-out ActLoopNT-out 9.2297 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_onno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -140.36 APE8-dihe-in -98.61, 79.73 APE8-rot-in 326.73 APE67-dihe-in -67.76, -12.96 -73.18, -22.73 APE12-dist-out 17.69 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.352 S218E,S222E,G328A None None XRAY 2.1 0.229 0.283 A 301.0 277.0 2 26 24 2 [[68, 361]] 1.0 4an3 STE_MAP2K1_HUMAN STE 1.7e-99 338.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3OS3A Q02750 62 378 393.0 ATP:1,3OS:400 ATPlike,Type3 Inactive DFGin 6.2398 13.5344 BLBplus -145.24, 170.05 62.26, 36.89 -93.68, 158.58 44.13, 99.29 -73.81, 106.93 out-out out 15.5039 Saltbr-out 15.3944 HRD-in -59.5, -62.21 84.93, 3.41 out-out-out SNCooo out-out ActLoopNT-out 9.408 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -133.7, -173.12 APE9-dihe-na 93.3, -146.81 APE8-dihe-out -139.28, -26.49 APE8-rot-out 64.05 APE67-dihe-out 179.14, 100.5 -105.07, -165.97 APE12-dist-out 14.8647 APE11-dist-out 20.0987 APE10-dist-out 20.8465 APE9-dist-out 14.0001 None None None XRAY 2.8 0.268 0.356 A 307.0 272.0 13 26 26 0 [[68, 361]] 1.0 3os3 STE_MAP2K1_HUMAN STE 9.7e-99 335.8 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3DV3A Q02750 62 382 393.0 ATP:69000,MEK:69001 ATPlike,Type3 Inactive DFGin 6.2483 13.6028 BLBplus -133.16, -177.92 60.69, 33.15 -89.5, 161.32 45.46, 91.05 -72.95, 66.6 out-out out 15.44 Saltbr-out 15.9198 HRD-in -71.02, -56.25 85.34, -10.2 out-out-out SNCooo out-out ActLoopNT-out 9.4338 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 147.19 APE8-dihe-out -113.44, 8.55 APE8-rot-out 63.26 APE67-dihe-out -136.65, 142.85 -161.65, 147.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.7228 None None None XRAY 2.3 0.184 0.221 A 322.0 287.0 34 26 23 3 [[68, 361]] 1.0 3dv3 STE_MAP2K1_HUMAN STE 1.2e-97 332.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3PP1A Q02750 62 382 393.0 ATP:60400,IZG:60500 ATPlike,Type3 Inactive DFGin 6.2434 13.5326 BLBplus -142.73, -172.37 57.21, 29.66 -83.48, 161.89 45.19, 86.92 -94.1, 95.51 out-out out 15.5755 Saltbr-out 15.6643 HRD-in -75.88, -59.97 91.29, -12.92 out-out-out SNCooo out-out ActLoopNT-out 9.8367 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -95.93, 115.09 APE9-dihe-na -80.03, 20.28 APE8-dihe-out -149.74, -167.9 APE8-rot-out 183.56 APE67-dihe-out -104.62, 136.28 16.12, 99.01 APE12-dist-out 17.8027 APE11-dist-out 17.6574 APE10-dist-out 19.8725 APE9-dist-out 14.6223 None None None XRAY 2.7 0.184 0.219 A 328.0 290.0 31 26 26 0 [[68, 361]] 1.0 3pp1 STE_MAP2K1_HUMAN STE 1.3e-97 332.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3EQBA Q02750 62 382 393.0 ATP:69001,LUG:60001 ATPlike,Type3 Inactive DFGin 6.3666 13.8165 BLBplus -126.21, -166.87 50.54, 41.27 -103.19, 173.93 44.2, 81.11 -86.45, 70.56 out-out out 15.5513 Saltbr-out 16.0995 HRD-in -69.12, -59.32 92.15, -13.52 out-out-out SNCooo out-out ActLoopNT-out 9.4116 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -145.13 APE9-dihe-na 160.93, -130.46 APE8-dihe-out -134.08, -9.84 APE8-rot-out 185.08 APE67-dihe-out -100.78, 136.47 -136.54, 109.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.269 APE9-dist-out 13.0736 None None None XRAY 2.62 0.212 0.264 A 333.0 288.0 33 26 23 3 [[68, 361]] 1.0 3eqb STE_MAP2K1_HUMAN STE 1.4e-97 332.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 1S9JA Q02750 62 382 393.0 ATP:60535,BBM:61001 ATPlike,Type3 Inactive DFGin 6.0381 13.6765 BLBplus -128.29, 177.35 60.26, 51.07 -106.68, 166.27 42.89, 83.29 -88.36, 87.09 out-out out 15.6483 Saltbr-out 16.0046 HRD-in -74.19, -52.1 76.2, -2.79 out-out-out SNCooo out-out ActLoopNT-out 9.3469 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -65.48 APE9-dihe-na 93.04, 154.36 APE8-dihe-out -82.85, 11.58 APE8-rot-out 188.1 APE67-dihe-out -101.56, 129.66 -130.71, 111.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.1483 APE9-dist-out 12.5588 None None None XRAY 2.4 0.246 0.269 A 341.0 288.0 33 26 23 3 [[68, 361]] 1.0 1s9j STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3DY7A Q02750 62 364 393.0 ATP:9000,1CX:9002 ATPlike,Type3 Inactive DFGin 6.1717 13.7583 BLBplus -135.89, -175.79 54.31, 45.87 -100.93, 164.77 46.33, 84.08 -87.96, 76.55 out-out out 15.2441 Saltbr-out 15.5792 HRD-in -80.68, -50.01 86.81, -10.3 out-out-out SNCooo out-out ActLoopNT-out 9.4633 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -93.77 APE8-dihe-out -68.47, -78.94 APE8-rot-in 288.45 APE67-dihe-out -129.83, 139.32 -78.41, 146.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.0637 None None None XRAY 2.7 0.248 0.269 A 341.0 260.0 43 26 23 3 [[68, 361]] 1.0 3dy7 STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3E8NA Q02750 62 382 393.0 ATP:60600,VRA:61001 ATPlike,Type3 Inactive DFGin 6.1947 13.8185 BLBplus -141.11, 177.37 57.45, 45.25 -100.77, 153.06 46.07, 82.11 -71.63, 93.26 out-out out 15.4133 Saltbr-out 15.3475 HRD-in -66.77, -56.92 83.67, -13.1 out-out-out SNCooo out-out ActLoopNT-out 9.4321 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_onoo APE10-dihe-na 999.0, -90.03 APE9-dihe-na 88.43, 141.27 APE8-dihe-out -49.1, -69.8 APE8-rot-out 147.13 APE67-dihe-out -116.51, 140.9 -59.5, 122.62 APE12-dist-out 18.8826 APE11-dist-none 999.0 APE10-dist-out 19.9857 APE9-dist-out 12.8311 None None None XRAY 2.5 0.219 0.252 A 341.0 290.0 31 26 25 1 [[68, 361]] 1.0 3e8n STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3VVHA Q02750 62 382 393.0 ATP:60702,4BM:60703 ATPlike,Type3 Inactive DFGin 6.3887 13.6564 BLBplus -137.53, 173.5 63.48, 33.18 -82.96, 158.78 37.49, 96.63 -83.81, 69.64 out-out out 15.318 Saltbr-out 14.9475 HRD-in -72.04, -55.34 81.65, -10.46 out-out-out SNCooo out-out ActLoopNT-out 9.2611 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -67.32 APE8-rot-in 311.04 APE67-dihe-out -121.47, 130.33 -95.91, 138.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.199 0.225 A 341.0 286.0 35 26 21 5 [[68, 361]] 1.0 3vvh STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3VVHB Q02750 62 382 393.0 ATP:60502,4BM:60503 ATPlike,Type3 Inactive DFGin 6.1391 13.837 BLBplus -134.79, 175.55 59.54, 35.53 -87.99, 165.28 42.27, 92.99 -92.68, 76.34 out-out out 15.2611 Saltbr-out 14.9773 HRD-in -72.52, -58.36 78.03, -3.83 out-out-out SNCooo out-out ActLoopNT-out 9.105 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -110.08, 147.03 APE9-dihe-na 98.19, 168.29 APE8-dihe-out -85.55, -32.58 APE8-rot-in 303.1 APE67-dihe-out -124.7, 138.59 -110.8, 145.07 APE12-dist-out 16.9705 APE11-dist-out 20.5595 APE10-dist-out 18.8507 APE9-dist-out 12.9264 None None None XRAY 2.0 0.199 0.225 B 341.0 289.0 32 26 26 0 [[68, 361]] 1.0 3vvh STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3VVHC Q02750 62 381 393.0 ATP:60502,4BM:60503 ATPlike,Type3 Inactive DFGin 6.1194 13.8842 BLBplus -136.04, 173.19 62.4, 33.8 -87.32, 164.72 43.72, 90.03 -81.06, 61.43 out-out out 15.3952 Saltbr-out 14.9059 HRD-in -71.92, -60.52 80.82, -10.24 out-out-out SNCooo out-out ActLoopNT-out 9.0055 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -107.33, 145.59 APE9-dihe-na 98.43, 176.47 APE8-dihe-out -99.48, -17.12 APE8-rot-out 62.73 APE67-dihe-out -124.21, 136.5 -120.29, 144.56 APE12-dist-out 16.9183 APE11-dist-out 20.6229 APE10-dist-out 18.8043 APE9-dist-out 12.9647 None None None XRAY 2.0 0.199 0.225 C 341.0 282.0 38 26 26 0 [[68, 361]] 1.0 3vvh STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 2P55A Q02750 62 382 393.0 MRA:69000,ATP:69001 Type3,ATPlike Inactive DFGin 6.1626 13.3824 BLBplus -134.23, -173.95 50.87, 43.67 -95.4, 166.24 42.0, 89.87 -87.86, 76.42 out-out out 15.2177 Saltbr-out 15.3456 HRD-in -70.81, -55.41 89.6, -22.02 out-out-out SNCooo out-out ActLoopNT-out 9.468 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -78.03 APE9-dihe-na 94.66, -135.55 APE8-dihe-out -131.47, -8.61 APE8-rot-out 200.5 APE67-dihe-out -121.47, 132.61 -102.76, 124.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.1744 APE9-dist-out 13.9789 None None None XRAY 2.8 0.228 0.301 A 333.0 288.0 33 26 23 3 [[68, 361]] 1.0 2p55 STE_MAP2K1_HUMAN STE 1.4e-97 332.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3V01A Q02750 62 382 393.0 3V0:60501,ATP:60502 Type3,ATPlike Inactive DFGin 6.105 13.4244 BLBplus -142.06, -173.42 54.59, 34.91 -91.82, 163.8 47.01, 90.27 -88.09, 75.03 out-out out 15.5642 Saltbr-out 15.7785 HRD-in -62.64, -63.68 88.6, -7.02 out-out-out SNCooo out-out ActLoopNT-out 9.2768 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -67.65 APE9-dihe-na 102.3, -166.23 APE8-dihe-out -116.29, 3.8 APE8-rot-out 189.24 APE67-dihe-out -108.4, 130.42 -142.07, 120.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.0771 APE9-dist-out 12.8379 None None None XRAY 2.705 0.189 0.24 A 341.0 288.0 33 26 23 3 [[68, 361]] 1.0 3v01 STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3V04A Q02750 62 382 393.0 V04:60501,ATP:60502 Type3,ATPlike Inactive DFGin 6.2019 13.4656 BLBplus -139.99, -177.53 54.26, 36.29 -92.6, 163.3 43.17, 90.4 -92.7, 75.2 out-out out 15.6131 Saltbr-out 16.0488 HRD-in -56.82, -58.2 81.63, -6.31 out-out-out SNCooo out-out ActLoopNT-out 9.1096 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -43.92 APE9-dihe-na 143.86, 160.52 APE8-dihe-out -85.24, -10.44 APE8-rot-out 182.43 APE67-dihe-out -103.47, 130.39 -134.15, 117.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.8085 APE9-dist-out 12.649 None None None XRAY 2.7 0.213 0.243 A 341.0 288.0 33 26 23 3 [[68, 361]] 1.0 3v04 STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K2 MP2K2_HUMAN 1S9IA P36507 60 393 400.0 ATP:535,5EA:1001 ATPlike,Type3 Inactive DFGin 6.2872 13.2689 BLBplus -139.34, -174.92 56.51, 21.27 -79.15, 150.55 47.45, 91.25 -79.77, 85.37 out-out out 15.5294 Saltbr-out 17.2975 HRD-out -62.14, 153.21 -129.12, 19.13 out-out-out SNCooo out-out ActLoopNT-out 8.8978 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnoo APE10-dihe-na 999.0, 134.1 APE9-dihe-na -103.89, 62.93 APE8-dihe-out -65.91, -35.32 APE8-rot-in 354.81 APE67-dihe-out -93.63, 150.37 -174.34, 119.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 21.6182 APE9-dist-out 12.7323 None None None XRAY 3.2 0.294 0.364 A 354.0 303.0 31 26 22 4 [[72, 369]] 1.0 1s9i STE_MAP2K2_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 211 212 213 215 217 101 118 122 191 193 192 194.0 249 237 232 231 230 229 228 227 226 148 Dual specificity mitogen-activated protein kinase kinase 2
STE MAP2K2 MP2K2_HUMAN 1S9IB P36507 59 389 400.0 ATP:537,5EA:1002 ATPlike,Type3 Inactive DFGin 6.2824 13.6383 BLBplus -139.5, 161.8 56.55, 60.44 -106.38, 150.17 37.7, 87.0 -78.89, 77.21 out-out out 15.5341 Saltbr-out 15.0044 HRD-out -92.42, 79.21 -68.62, 14.72 out-out-out SNCooo out-out ActLoopNT-out 9.5166 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -33.93 APE8-rot-out 15.08 APE67-dihe-out -144.19, 132.88 -117.04, 157.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.294 0.364 B 354.0 291.0 40 26 20 6 [[72, 369]] 1.0 1s9i STE_MAP2K2_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 211 212 213 215 217 101 118 122 191 193 192 194.0 249 237 232 231 230 229 228 227 226 148 Dual specificity mitogen-activated protein kinase kinase 2
STE PAK1 PAK1_HUMAN 3Q53A Q13153 250 541 545.0 ATP:1 ATPlike None DFGin 6.5457 15.9679 BLAminus -131.41, -173.51 59.18, 73.62 -91.64, 12.88 288.75, 75.16 -60.67, -19.44 out-none out 10.1595 Saltbr-none 999.0 HRD-in -69.79, -48.58 76.19, -3.19 none-in-in SNCnii in-in ActLoopNT-in 2.8373 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.58, -17.38 APE9-dihe-na -66.64, 179.65 APE8-dihe-in -103.57, 123.03 APE8-rot-in 305.32 APE67-dihe-in -60.91, -26.26 -42.88, -52.15 APE12-dist-in 8.284 APE11-dist-in 10.4631 APE10-dist-in 4.7272 APE9-dist-in 3.4382 K299R,L516I TPO423 TPO423 XRAY 2.09 0.207 0.223 A 306.0 292.0 0 28 28 0 [[270, 521]] 1.0 3q53 STE_PAK1_HUMAN STE 2.5e-94 321.4 1.0 257.0 257.0 406 407 408 410 412 299 315 319 386 388 387 389.0 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK4 PAK4_HUMAN 4XBRA O96013 177 589 591.0 ATP:60601 ATPlike Inactive DFGin 5.8522 14.0612 ABAminus -142.04, -22.23 -111.42, 72.59 -86.56, 10.51 310.81, 99.4 -46.84, -40.66 in-in in 7.0094 Saltbr-in 3.1584 HRD-in -84.11, -33.57 58.48, -1.88 in-in-in SNCiii in-in ActLoopNT-in 2.9736 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.96, 132.02 APE9-dihe-na 150.85, -176.82 APE8-dihe-in -102.34, 122.5 APE8-rot-in 312.14 APE67-dihe-in -59.91, -25.15 -35.82, -60.88 APE12-dist-in 9.3349 APE11-dist-in 11.9274 APE10-dist-in 6.0495 APE9-dist-in 3.3957 None SEP474 SEP474 XRAY 2.94 0.191 0.23 A 366.0 293.0 0 28 28 0 [[321, 572]] 1.0 4xbr STE_PAK4_HUMAN STE 3.7e-88 301.2 5.0 257.0 253.0 457 458 459 461 463 350 366 370 437 439 438 440.0 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE STK24 STK24_HUMAN 3A7HA Q9Y6E0 18 310 443.0 ATP:60400 ATPlike Inactive DFGin 6.2741 16.0602 BLAminus -135.27, 174.99 54.48, 64.86 -70.71, -58.08 287.78, 76.92 45.88, -44.99 in-out in 9.7224 Saltbr-out 4.4927 HRD-in -66.74, -51.36 77.62, -11.47 out-in-in SNCoii in-in ActLoopNT-in 2.7975 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.61, 151.93 APE9-dihe-na 118.1, -167.87 APE8-dihe-in -108.64, 120.02 APE8-rot-in 324.07 APE67-dihe-in -58.13, -27.9 -30.96, -56.98 APE12-dist-in 8.2692 APE11-dist-in 11.1373 APE10-dist-in 5.5434 APE9-dist-in 3.5657 None TPO190 TPO190 XRAY 1.96 0.21 0.252 A 303.0 290.0 0 28 28 0 [[36, 286]] 1.0 3a7h STE_STK24_HUMAN STE 3.6e-100 340.5 1.0 257.0 257.0 173 174 175 177 179 65 82 86 153 155 154 156.0 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 3A7HB Q9Y6E0 17 310 443.0 ATP:60400 ATPlike Inactive DFGin 6.6847 16.8596 BLAminus -138.1, 177.76 56.48, 71.8 -87.83, 21.17 281.85, 78.43 -54.77, -28.24 out-out out 10.376 Saltbr-out 4.6392 HRD-in -73.68, -49.41 75.79, -7.51 out-in-in SNCoii in-in ActLoopNT-in 2.8157 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.6, 158.04 APE9-dihe-na 117.1, -164.51 APE8-dihe-in -112.27, 119.11 APE8-rot-in 308.97 APE67-dihe-in -56.45, -30.21 -34.32, -55.35 APE12-dist-in 8.2153 APE11-dist-in 11.0119 APE10-dist-in 5.2611 APE9-dist-in 3.4012 None TPO190 TPO190 XRAY 1.96 0.21 0.252 B 303.0 291.0 0 28 28 0 [[36, 286]] 1.0 3a7h STE_STK24_HUMAN STE 3.6e-100 340.5 1.0 257.0 257.0 173 174 175 177 179 65 82 86 153 155 154 156.0 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STRADA STRAA_HUMAN 3GNIB Q7RTN6 60 431 431.0 ATP:60001 ATPlike Pseudo DFGin 5.2283 13.3577 BLAminus -109.39, -155.43 74.77, 29.57 -67.06, -15.75 299.34, 10.06 -54.98, -34.79 in-none in 9.8996 Saltbr-none 999.0 HRD-in -71.88, -63.47 83.33, 4.11 none-in-out SNCnio in-out ActLoopNT-in 2.866 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_iooo APE10-dihe-na -73.5, 108.36 APE9-dihe-na 128.9, -33.16 APE8-dihe-out -82.37, -8.26 APE8-rot-na 193.56 APE67-dihe-in -56.7, -25.37 -48.29, -50.45 APE12-dist-in 8.5274 APE11-dist-out 7.0984 APE10-dist-out 12.8989 APE9-dist-out 9.8974 None None None XRAY 2.35 0.207 0.254 B 389.0 290.0 56 35 35 0 [[69, 379]] 1.0 3gni STE_STRADA_HUMAN STE 4.7e-87 297.8 1.0 257.0 257.0 212 213 214 216 218 100 118 122 192 194 193 195.0 261 247 242 241 240 239 238 237 236 148 STE20-related kinase adapter protein alpha
TKL ILK ILK_HUMAN 9D5IA Q13418 182 452 452.0 ATP:502 ATPlike Pseudo DFGinter 8.2613 6.8416 None -85.91, 104.5 -70.94, -26.25 -67.8, 1.23 999.0, 999.0 -109.51, 3.6 out-out out 13.6108 Saltbr-out 13.7768 HRD-out 63.45, 28.98 -91.0, 110.88 out-out-out SNCooo out-out ActLoopNT-out 6.365 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioo APE10-dihe-na -132.95, 115.89 APE9-dihe-na -99.41, -2.16 APE8-dihe-in -138.47, 54.8 APE8-rot-none 999.0 APE67-dihe-in -62.49, -23.03 -64.85, -19.12 APE12-dist-out 14.7048 APE11-dist-in 13.9898 APE10-dist-out 13.1384 APE9-dist-out 13.2651 R225A,C346S,C422S None None XRAY 1.5 0.23 0.267 A 271.0 271.0 0 23 23 0 [[192, 448]] 1.0 9d5i TKL_ILK_HUMAN TKL 2.8e-62 216.7 3.0 267.0 265.0 336 337 338 340 342 220 238 242 316 318 317 319.0 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 3KMWA Q13418 185 452 452.0 ATP:502 ATPlike Pseudo DFGinter 8.2996 6.9752 None -80.97, 99.65 -67.11, -24.75 -72.37, 0.55 999.0, 999.0 -103.25, 4.58 out-out out 13.4961 Saltbr-out 14.0409 HRD-out 59.64, 26.4 -91.04, 116.86 out-out-out SNCooo out-out ActLoopNT-out 6.3674 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -122.08, 118.72 APE9-dihe-na -100.74, -5.98 APE8-dihe-in -137.53, 58.2 APE8-rot-none 999.0 APE67-dihe-in -63.57, -23.06 -67.47, -16.05 APE12-dist-out 14.7099 APE11-dist-out 14.0404 APE10-dist-out 13.057 APE9-dist-out 13.0267 C346S,C422S None None XRAY 2.0 0.199 0.203 A 271.0 268.0 0 23 23 0 [[192, 448]] 1.0 3kmw TKL_ILK_HUMAN TKL 1.5e-62 217.5 3.0 267.0 265.0 336 337 338 340 342 220 238 242 316 318 317 319.0 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 3REPA Q13418 185 452 452.0 ATP:502 ATPlike Pseudo DFGinter 8.264 6.8945 None -81.35, 101.61 -70.12, -25.38 -69.18, -5.31 999.0, 999.0 -98.03, -0.84 out-out out 13.3586 Saltbr-out 14.1198 HRD-out 62.24, 23.62 -86.21, 112.03 out-out-out SNCooo out-out ActLoopNT-out 6.4539 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioo APE10-dihe-na -114.84, 122.73 APE9-dihe-na -97.69, -5.36 APE8-dihe-in -136.02, 58.25 APE8-rot-none 999.0 APE67-dihe-in -57.73, -27.19 -63.83, -23.69 APE12-dist-out 14.4979 APE11-dist-in 13.9809 APE10-dist-out 12.9395 APE9-dist-out 13.101 C346S,C422S None None XRAY 1.8 0.206 0.238 A 271.0 268.0 0 23 23 0 [[192, 448]] 1.0 3rep TKL_ILK_HUMAN TKL 1.5e-62 217.5 3.0 267.0 265.0 336 337 338 340 342 220 238 242 316 318 317 319.0 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL KSR2 KSR2_HUMAN 2Y4IB Q6VAB6 653 931 950.0 ATP:1932 ATPlike Pseudo DFGin 6.0393 13.3572 BLBplus -163.04, 167.92 56.95, 32.67 -75.07, 155.41 46.1, 92.34 53.05, 51.5 out-none out 15.5798 Saltbr-none 999.0 HRD-in -80.25, -38.53 67.56, -67.09 none-out-out SNCnoo out-out ActLoopNT-out 10.4303 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -56.45, -137.53 APE9-dihe-na -67.8, 7.84 APE8-dihe-out -54.46, -37.41 APE8-rot-na 170.99 APE67-dihe-in -92.05, 13.42 -60.84, -28.22 APE12-dist-out 17.417 APE11-dist-out 14.5757 APE10-dist-out 17.158 APE9-dist-out 12.2619 None None None XRAY 3.46 0.233 0.293 B 319.0 265.0 14 33 23 10 [[665, 930]] 1.0 2y4i TKL_KSR2_HUMAN TKL 1.1e-70 244.1 2.0 267.0 266.0 802 803 804 806 808 692 710 714 783 785 784 786.0 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL LRRK2 LRRK2_HUMAN 8FO9A Q5S007 1329 2527 2527.0 ATP:2602 ATPlike Active DFGin 6.2733 13.4102 BLAminus -138.23, -175.7 59.6, 64.71 -84.85, 53.99 305.84, 101.34 -78.49, -28.55 in-in in 7.8797 Saltbr-in 2.7348 HRD-in -107.83, -47.31 66.25, 1.81 in-in-in SNCiii in-in ActLoopNT-in 3.031 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.21, 156.34 APE9-dihe-na 139.24, 152.96 APE8-dihe-in -67.96, 127.7 APE8-rot-in 305.42 APE67-dihe-inflip 98.56, -16.69 -58.5, 136.92 APE12-dist-in 9.1834 APE11-dist-in 11.4868 APE10-dist-in 6.0039 APE9-dist-in 3.8159 None None None EM 3.48 999.0 999.0 A 2527.0 1173.0 0 26 26 0 [[1875, 2134]] 1.0 8fo9 TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO9C Q5S007 1329 2527 2527.0 ATP:2602 ATPlike Active DFGin 6.2753 13.4053 BLAminus -138.14, -175.77 59.5, 64.85 -84.95, 53.97 305.9, 101.31 -78.52, -28.52 in-in in 7.8828 Saltbr-in 2.7293 HRD-in -108.59, -47.2 66.33, 1.76 in-in-in SNCiii in-in ActLoopNT-in 3.008 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.94, 156.21 APE9-dihe-na 139.37, 152.96 APE8-dihe-in -67.92, 127.71 APE8-rot-in 305.58 APE67-dihe-inflip 98.46, -16.81 -58.61, 136.94 APE12-dist-in 9.1767 APE11-dist-in 11.5032 APE10-dist-in 6.012 APE9-dist-in 3.8041 None None None EM 3.48 999.0 999.0 C 2527.0 1173.0 0 26 26 0 [[1875, 2134]] 1.0 8fo9 TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LHTA Q5S007 558 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 9.8435 8.2947 None -64.84, 122.35 -98.75, -0.04 -71.37, -28.28 172.84, 65.91 -59.04, -42.88 out-out out 11.1561 Saltbr-out 7.8414 HRD-in -69.75, -40.92 72.72, -9.61 out-out-out SNCooo out-out ActLoopNT-out 9.7836 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -82.21, -17.19 APE9-dihe-na 90.26, 154.46 APE8-dihe-in -57.7, 141.99 APE8-rot-in 318.57 APE67-dihe-in -63.97, -43.36 -55.36, -52.39 APE12-dist-in 9.6726 APE11-dist-in 10.1449 APE10-dist-out 14.0961 APE9-dist-in 4.0969 None None None EM 3.5 999.0 999.0 A 2527.0 1795.0 3 26 23 3 [[1875, 2134]] 1.0 7lht TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LHTB Q5S007 558 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 9.8435 8.2947 None -64.86, 122.35 -98.72, -0.04 -71.37, -28.3 172.84, 65.9 -59.09, -42.88 out-out out 11.1564 Saltbr-out 7.8415 HRD-in -69.81, -40.92 72.73, -9.55 out-out-out SNCooo out-out ActLoopNT-out 9.783 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -82.22, -17.15 APE9-dihe-na 90.23, 154.47 APE8-dihe-in -57.69, 142.03 APE8-rot-in 318.55 APE67-dihe-in -64.0, -43.36 -55.37, -52.4 APE12-dist-in 9.6725 APE11-dist-in 10.1447 APE10-dist-out 14.096 APE9-dist-in 4.0969 None None None EM 3.5 999.0 999.0 B 2527.0 1795.0 3 26 23 3 [[1875, 2134]] 1.0 7lht TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LHWA Q5S007 540 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 10.3492 8.2774 None -70.88, 117.76 -93.02, 2.5 -63.92, -24.19 170.47, 59.39 -60.34, -43.84 out-out out 10.98 Saltbr-out 7.2575 HRD-in -74.65, -33.87 72.74, -12.12 out-out-out SNCooo out-out ActLoopNT-out 9.6308 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -74.42, -8.25 APE9-dihe-na 81.17, 153.49 APE8-dihe-in -58.6, 142.93 APE8-rot-in 304.43 APE67-dihe-in -63.74, -43.48 -51.59, -53.96 APE12-dist-in 10.2362 APE11-dist-in 9.4572 APE10-dist-out 13.8716 APE9-dist-in 4.3352 None None None EM 3.7 999.0 999.0 A 2527.0 1813.0 3 26 23 3 [[1875, 2134]] 1.0 7lhw TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LI4A Q5S007 558 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 9.8442 8.2944 None -64.77, 122.33 -98.76, -0.03 -71.41, -28.21 172.83, 65.95 -59.02, -42.88 out-out out 11.1566 Saltbr-out 7.8416 HRD-in -69.78, -40.92 72.72, -9.67 out-out-out SNCooo out-out ActLoopNT-out 9.7838 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -82.19, -17.19 APE9-dihe-na 90.26, 154.48 APE8-dihe-in -57.73, 142.01 APE8-rot-in 318.58 APE67-dihe-in -63.98, -43.36 -55.36, -52.38 APE12-dist-in 9.6727 APE11-dist-in 10.1448 APE10-dist-out 14.0958 APE9-dist-in 4.0959 None None None EM 3.1 999.0 999.0 A 2527.0 1795.0 3 26 23 3 [[1875, 2134]] 1.0 7li4 TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO2E Q5S007 12 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 10.5492 8.1829 None -77.97, 115.31 -99.8, 16.1 -71.24, -24.34 179.0, 61.54 -64.41, -41.78 out-out out 11.347 Saltbr-out 7.8505 HRD-in -73.2, -35.27 72.81, -10.29 out-out-out SNCooo out-out ActLoopNT-out 9.492 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -67.29, -18.03 APE9-dihe-na 75.0, 160.57 APE8-dihe-in -64.56, 133.01 APE8-rot-in 300.63 APE67-dihe-in -63.84, -35.14 -59.88, -35.03 APE12-dist-in 9.1186 APE11-dist-in 10.5881 APE10-dist-out 14.4472 APE9-dist-in 4.3818 None None None EM 4.13 999.0 999.0 E 2527.0 2275.0 4 26 23 3 [[1875, 2134]] 1.0 8fo2 TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO8C Q5S007 12 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 10.4041 8.3667 None -77.76, 115.2 -99.79, 16.57 -70.68, -24.12 178.89, 61.58 -64.22, -41.72 out-out out 11.3412 Saltbr-out 7.7439 HRD-in -73.07, -35.29 72.76, -10.32 out-out-out SNCooo out-out ActLoopNT-out 9.4707 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -67.5, -18.26 APE9-dihe-na 74.89, 160.43 APE8-dihe-in -64.77, 133.4 APE8-rot-in 300.66 APE67-dihe-in -63.6, -35.05 -59.67, -34.64 APE12-dist-in 9.0713 APE11-dist-in 10.5217 APE10-dist-out 14.4112 APE9-dist-in 4.4488 None None None EM 3.88 999.0 999.0 C 2527.0 2270.0 4 26 23 3 [[1875, 2134]] 1.0 8fo8 TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO8E Q5S007 12 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 10.4146 8.3493 None -77.68, 115.13 -99.83, 16.55 -70.64, -24.07 178.91, 61.52 -64.18, -41.73 out-out out 11.3208 Saltbr-out 7.7298 HRD-in -73.0, -35.27 72.87, -10.42 out-out-out SNCooo out-out ActLoopNT-out 9.4702 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -67.4, -18.35 APE9-dihe-na 74.93, 160.44 APE8-dihe-in -64.61, 133.34 APE8-rot-in 300.72 APE67-dihe-in -63.56, -35.05 -59.56, -34.8 APE12-dist-in 9.056 APE11-dist-in 10.5258 APE10-dist-out 14.406 APE9-dist-in 4.4342 None None None EM 3.88 999.0 999.0 E 2527.0 2270.0 4 26 23 3 [[1875, 2134]] 1.0 8fo8 TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO9F Q5S007 12 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 9.3478 8.5752 None -68.36, 152.72 -137.53, 18.95 -81.54, -22.77 187.88, 51.61 -70.19, -36.74 out-out out 11.2379 Saltbr-out 8.3264 HRD-in -76.93, -42.26 72.06, -11.17 out-out-out SNCooo out-out ActLoopNT-out 9.1058 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -70.82, -18.07 APE9-dihe-na 87.94, 175.98 APE8-dihe-in -63.48, 135.16 APE8-rot-in 300.23 APE67-dihe-in -66.37, -45.6 -58.88, -37.04 APE12-dist-in 9.7177 APE11-dist-in 10.5775 APE10-dist-out 14.122 APE9-dist-in 4.4728 None None None EM 3.48 999.0 999.0 F 2527.0 2289.0 3 26 23 3 [[1875, 2134]] 1.0 8fo9 TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LI3A Q5S007 558 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 9.5831 8.4031 None -64.7, 121.5 -105.97, 8.82 -69.04, -26.41 175.66, 65.26 -63.25, -46.61 out-out out 11.4013 Saltbr-out 8.1206 HRD-in -76.04, -34.97 73.14, -12.04 out-out-out SNCooo out-out ActLoopNT-out 9.6644 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -85.32, -9.76 APE9-dihe-na 87.27, 160.92 APE8-dihe-in -56.79, 143.13 APE8-rot-in 300.33 APE67-dihe-in -63.35, -39.62 -56.92, -55.07 APE12-dist-in 10.3855 APE11-dist-in 10.3625 APE10-dist-out 14.0058 APE9-dist-in 3.6521 None None None EM 3.8 999.0 999.0 A 2527.0 1795.0 3 26 23 3 [[1875, 2134]] 1.0 7li3 TKL_LRRK2_HUMAN TKL 3.9e-56 197.0 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO9E Q5S007 12 2527 2527.0 ATP:2602 ATPlike Inactive DFGout 11.3745 7.913 None -68.54, 152.71 -137.53, 21.65 -90.85, -9.64 146.2, 91.59 -82.02, -36.47 out-out out 11.1602 Saltbr-out 8.209 HRD-in -76.97, -42.35 72.15, -11.11 out-out-out SNCooo out-out ActLoopNT-out 9.123 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -70.77, -18.05 APE9-dihe-na 87.91, 175.95 APE8-dihe-in -63.49, 135.16 APE8-rot-in 300.24 APE67-dihe-in -66.44, -45.65 -58.78, -37.14 APE12-dist-in 9.6513 APE11-dist-in 10.5523 APE10-dist-out 14.083 APE9-dist-in 4.472 None None None EM 3.48 999.0 999.0 E 2527.0 2287.0 3 26 23 3 [[1875, 2134]] 1.0 8fo9 TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TYR EGFR EGFR_HUMAN 8PO4B P00533 700 1014 1210.0 ATP:1101 ATPlike Inactive DFGin 5.6238 16.3937 BLBtrans -121.3, 175.63 63.19, 26.9 -63.92, 138.21 163.94, 68.04 83.38, -10.03 out-out out 13.6 Saltbr-out 13.0291 HRD-in -73.28, -55.5 80.32, -14.85 out-out-out SNCooo out-out ActLoopNT-out 6.4864 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 119.23 APE8-dihe-in -81.98, 63.66 APE8-rot-na 32.98 APE67-dihe-in -71.84, -8.05 -50.66, -40.3 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2552 V948R None None XRAY 1.621 0.211 0.243 B 328.0 295.0 20 30 17 13 [[712, 970]] 1.0 8po4 TYR_EGFR_HUMAN TYR 7.9e-88 300.2 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR INSR INSR_HUMAN 3BU5A P06213 1014 1310 1382.0 ATP:60300 ATPlike Active DFGin 6.6591 13.9339 BLAminus -128.64, -166.6 44.54, 89.54 -102.81, 23.91 295.82, 99.34 -57.5, -34.18 in-in in 8.2612 Saltbr-in 3.1304 HRD-in -68.86, -51.91 77.02, -10.33 in-in-in SNCiii in-in ActLoopNT-in 2.8444 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.0, 102.51 APE9-dihe-in -127.85, 151.44 APE8-dihe-in -79.76, 69.1 APE8-rot-na 32.47 APE67-dihe-in -66.77, -8.03 -57.27, -41.89 APE12-dist-na 15.9367 APE11-dist-na 11.7238 APE10-dist-na 11.3004 APE9-dist-in 7.4014 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 2.1 0.196 0.239 A 306.0 294.0 3 30 30 0 [[1023, 1292]] 1.0 3bu5 TYR_INSR_HUMAN TYR 1.3e-96 328.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR JAK2-1 JAK2_HUMAN 5I4NA O60674 537 809 1132.0 ATP:61000 ATPlike Pseudo DFGin 5.6682 13.3858 None -68.19, 172.29 -64.41, 158.19 -73.31, -26.63 342.84, 34.8 77.82, -169.16 out-na out 11.405 Saltbr-na 999.0 HRD-in -78.6, -60.98 86.96, 3.87 na-out-out SNCaoo out-out ActLoopNT-out 8.6814 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.12, -41.49 APE9-dihe-out -58.18, -29.35 APE8-dihe-out -88.11, 6.74 APE8-rot-na 290.83 APE67-dihe-out -103.83, 26.01 -65.06, 135.53 APE12-dist-na 10.0371 APE11-dist-na 11.7 APE10-dist-na 16.2781 APE9-dist-out 12.3723 E596A,V617F,W659A,W777A,F794H None None XRAY 1.54 0.174 0.193 A 290.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5i4n TYR_JAK2-1_HUMAN TYR 7.1e-64 221.5 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 4FVRA O60674 536 809 1132.0 ATP:901 ATPlike Pseudo DFGin 5.7656 13.3758 None -77.86, -178.54 -72.61, 163.95 -75.06, -27.39 334.11, 39.64 77.27, -166.65 out-na out 11.7821 Saltbr-na 999.0 HRD-in -74.66, -57.27 90.8, -3.55 na-out-out SNCaoo out-out ActLoopNT-out 8.5367 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.48, -33.68 APE9-dihe-out -63.8, -34.8 APE8-dihe-out -85.1, 11.44 APE8-rot-na 293.02 APE67-dihe-out -101.64, 24.24 -66.8, 135.55 APE12-dist-na 9.675 APE11-dist-na 11.4734 APE10-dist-na 16.0369 APE9-dist-out 12.0279 V617F,W777A,F794H None None XRAY 2.0 0.183 0.229 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 4fvr TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 4FVQA O60674 536 809 1132.0 ATP:901 ATPlike Pseudo DFGin 6.4109 13.5312 None -82.38, -178.3 -71.29, 157.18 -64.23, -31.16 342.38, 32.32 77.45, -167.94 out-na out 10.3574 Saltbr-na 999.0 HRD-in -81.79, -59.57 93.66, -10.87 na-out-out SNCaoo out-out ActLoopNT-out 9.0941 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.14, -35.28 APE9-dihe-out -67.39, -22.98 APE8-dihe-out -92.26, 6.93 APE8-rot-na 290.03 APE67-dihe-out -106.47, 27.81 -64.4, 133.6 APE12-dist-na 9.9123 APE11-dist-na 11.4873 APE10-dist-na 16.0746 APE9-dist-out 12.3782 W659A,W777A,F794H None None XRAY 1.75 0.176 0.199 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 4fvq TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C08A O60674 537 810 1132.0 ATP:901 ATPlike Pseudo DFGin 6.5983 13.736 None -72.21, 176.69 -66.6, 164.57 -72.8, -15.2 349.18, 27.02 73.34, -163.25 in-na in 9.3998 Saltbr-na 999.0 HRD-in -80.72, -74.63 111.24, -16.83 na-out-out SNCaoo out-out ActLoopNT-out 9.4736 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -55.86, -37.52 APE9-dihe-out -72.05, -28.92 APE8-dihe-out -74.69, -10.21 APE8-rot-na 283.12 APE67-dihe-out -93.42, 18.23 -54.81, 139.34 APE12-dist-na 9.9203 APE11-dist-na 11.8594 APE10-dist-na 16.3524 APE9-dist-out 12.5304 W659A,W777A,F794H None None XRAY 2.2 0.267 0.259 A 289.0 270.0 4 24 24 0 [[545, 807], [849, 1125]] 2.0 8c08 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C08B O60674 536 810 1132.0 ATP:901 ATPlike Pseudo DFGin 5.6459 13.5394 None -63.04, -178.12 -72.48, 164.14 -59.19, -39.37 337.51, 34.58 89.58, -173.09 out-na out 12.1784 Saltbr-na 999.0 HRD-in -76.08, -63.96 89.49, 0.26 na-out-out SNCaoo out-out ActLoopNT-out 8.7296 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.09, -36.29 APE9-dihe-out -67.21, -14.45 APE8-dihe-out -97.09, 0.9 APE8-rot-na 279.42 APE67-dihe-out -95.31, 21.21 -63.75, 135.54 APE12-dist-na 10.8478 APE11-dist-na 11.8372 APE10-dist-na 16.5999 APE9-dist-out 12.658 W659A,W777A,F794H None None XRAY 2.2 0.267 0.259 B 289.0 269.0 6 24 24 0 [[545, 807], [849, 1125]] 2.0 8c08 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR MET MET_HUMAN 3DKCA P08581 1051 1360 1390.0 ATP:60001 ATPlike Inactive DFGin 5.6932 13.1031 BLBplus -128.11, 162.74 67.51, 17.44 -61.67, 130.17 44.2, 92.69 80.08, -22.94 out-out out 14.0828 Saltbr-out 12.8365 HRD-in -71.17, -57.45 82.5, -22.81 out-out-out SNCooo out-out ActLoopNT-out 7.7392 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -83.24, -9.16 APE9-dihe-in -104.14, 150.23 APE8-dihe-in -75.82, 62.17 APE8-rot-na 30.64 APE67-dihe-in -64.7, -18.65 -61.74, -26.11 APE12-dist-na 18.5297 APE11-dist-na 20.199 APE10-dist-na 15.662 APE9-dist-out 9.0723 Y1194F,Y1234F,Y1235D None None XRAY 1.52 0.189 0.218 A 317.0 310.0 0 32 32 0 [[1078, 1339]] 1.0 3dkc TYR_MET_HUMAN TYR 8.6e-90 306.9 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR PTK2 FAK1_HUMAN 2IJMA Q05397 414 688 1052.0 ATP:690 ATPlike Inactive DFGin 5.3348 15.2552 None -130.4, -10.41 -96.6, 92.35 -115.09, 154.36 308.92, 97.78 84.66, -9.12 in-in in 7.6024 Saltbr-in 2.5443 HRD-in -77.84, -47.69 90.07, -21.21 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -43.55 APE8-dihe-in -70.98, 54.52 APE8-rot-na 26.91 APE67-dihe-in -71.31, -14.5 -49.75, -42.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.5309 None None None XRAY 2.187 0.211 0.271 A 281.0 260.0 15 29 14 15 [[422, 678]] 1.0 2ijm TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1

Ligand: ATP

Total number of chains: 237
Active chains: 97
Total number of genes: 49
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 155 65.4% 5LVOA
DFGin None 24 10.1% 5I4NA
DFGin BLBplus 23 9.7% 3DKCA
DFGinter None 14 5.9% 9D5IA
DFGin BLBtrans 8 3.4% 1HCKA
None None 5 2.1% 4FI1A
DFGin ABAminus 4 1.7% 7T4TA
DFGin BLBminus 3 1.3% 7Z9TBBB
DFGout None 1 0.4% 8FO9E

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL BRI1 BRI1_ARATH 5LPYA O22476 867 1160 1196.0 ATP:1200 ATPlike Active DFGin 5.1746 15.2032 BLAminus -134.16, 179.9 60.37, 82.56 -100.0, 17.51 285.92, 71.71 -57.07, -20.27 in-in in 8.8923 Saltbr-in 3.1518 HRD-in -70.7, -49.88 77.86, -1.82 in-in-in SNCiii in-in ActLoopNT-in 2.9078 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.47, 151.76 APE9-dihe-na 140.48, 176.99 APE8-dihe-in -121.99, 138.13 APE8-rot-in 307.91 APE67-dihe-inflip 92.03, -10.16 -52.79, 133.04 APE12-dist-in 9.6093 APE11-dist-in 11.5236 APE10-dist-in 5.7212 APE9-dist-in 3.8848 T872A TPO1039,SEP1042,SEP1044,SEP1060 TPO1039,SEP1042,SEP1044,SEP1060 XRAY 2.3 0.203 0.248 A 296.0 286.0 8 30 30 0 [[882, 1157]] 1.0 5lpy Arabidopsis thaliana TKL_BRI1_ARATH TKL 2e-63 220.4 4.0 266.0 263.0 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009.0 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL FERONIA FERON_ARATH 7XDVA Q9SCZ4 521 815 895.0 ATP:60401 ATPlike None DFGin 6.6994 15.5725 BLAminus -134.27, 177.47 68.35, 79.21 -98.58, 11.5 282.56, 76.24 -59.84, -20.83 in-none in 8.7227 Saltbr-none 999.0 HRD-in -67.4, -48.26 73.32, 1.35 none-in-none SNCnin in-none ActLoopNT-in 2.9051 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 147.64 APE8-rot-in 320.48 APE67-dihe-in -72.12, 2.13 -58.53, -58.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.97 0.172 0.213 A 313.0 283.0 12 30 18 12 [[535, 809]] 1.0 7xdv Arabidopsis thaliana TKL_FERONIA_ARATH TKL 8.2e-57 198.7 3.0 266.0 264.0 678 679 680 682 684 565 581 585 658 660 659 661.0 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
TKL FERONIA FERON_ARATH 7XDVB Q9SCZ4 522 816 895.0 ATP:60401 ATPlike None DFGin 6.6762 15.7003 BLAminus -133.75, 179.29 66.82, 78.34 -97.78, 11.62 279.93, 76.8 -60.95, -21.55 in-none in 8.917 Saltbr-none 999.0 HRD-in -65.85, -46.61 72.82, 0.74 none-in-none SNCnin in-none ActLoopNT-in 2.8555 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 149.11 APE8-rot-in 319.48 APE67-dihe-in -72.05, 2.55 -59.63, -58.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.97 0.172 0.213 B 313.0 283.0 12 30 18 12 [[535, 809]] 1.0 7xdv Arabidopsis thaliana TKL_FERONIA_ARATH TKL 8.2e-57 198.7 3.0 266.0 264.0 678 679 680 682 684 565 581 585 658 660 659 661.0 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
OTHER LANKC A0A6H0TJ16_BACTU 8SAMA A0A6H0TJ16 1 862 872.0 ATP:60902 ATPlike None DFGin 6.6401 14.881 BLAminus -119.81, 176.45 65.16, 86.81 -107.13, 32.95 280.75, 71.48 -74.73, -19.84 in-in in 7.4098 Saltbr-in 2.7754 HRD-na- -76.54, -26.64 101.12, -25.28 in-in-none SNCiin in-none ActLoopNT-in 2.7503 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.15 0.205 0.251 A 904.0 845.0 0 -381 -381 0 [[228, 410]] 1.0 8sam Bacillus thuringiensis serovar andalousiensis OTHER_LANKC_BACTU CAMK 1.4e-13 57.3 1.0 164.0 164.0 381 382 383 385 387 257 279 283 361 363 362 364.0 0 0 0 0 0 0 0 0 0 310 Class III lanthionine synthetase LanKC
OTHER LANKC A0A6H0TJ16_BACTU 8SAMB A0A6H0TJ16 1 862 872.0 ATP:60901 ATPlike Inactive DFGin 6.7493 15.0087 BLAminus -116.86, 172.09 66.52, 88.25 -108.59, 34.42 278.94, 73.78 -73.89, -19.99 in-out in 7.4791 Saltbr-out 3.8646 HRD-na- -85.28, 118.03 -78.23, 6.03 out-in-none SNCoin in-none ActLoopNT-in 2.7645 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.15 0.205 0.251 B 904.0 844.0 0 -381 -381 0 [[228, 410]] 1.0 8sam Bacillus thuringiensis serovar andalousiensis OTHER_LANKC_BACTU CAMK 1.4e-13 57.3 1.0 164.0 164.0 381 382 383 385 387 257 279 283 361 363 362 364.0 0 0 0 0 0 0 0 0 0 310 Class III lanthionine synthetase LanKC
AGC GRK1 GRK1_BOVIN 3T8OA P28327 30 532 561.0 ATP:562 ATPlike Active DFGin 6.784 13.6519 BLAminus -147.61, 176.5 66.51, 86.5 -106.39, 20.07 278.45, 121.96 -78.51, -8.51 in-in in 9.1312 Saltbr-in 2.9462 HRD-in -72.08, -59.57 74.93, 15.13 in-in-in SNCiii in-in ActLoopNT-in 3.0341 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.6, 145.4 APE9-dihe-na 140.82, -165.62 APE8-dihe-in -114.33, 123.31 APE8-rot-in 302.45 APE67-dihe-inflip 90.49, -9.25 -48.36, 136.06 APE12-dist-in 10.4193 APE11-dist-in 11.6453 APE10-dist-in 5.7954 APE9-dist-in 4.2758 L166K None None XRAY 2.5 0.209 0.245 A 543.0 493.0 0 28 28 0 [[187, 452]] 1.0 3t8o Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4.0 260.0 257.0 331 332 333 335 337 216 235 239 311 313 312 314.0 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C4WA P28327 31 533 561.0 ATP:562 ATPlike Active DFGin 6.5874 13.3137 BLAminus -157.51, 175.0 67.79, 80.23 -106.97, 21.1 277.77, 138.55 -72.95, -18.52 in-in in 8.6705 Saltbr-in 2.6589 HRD-in -67.86, -51.97 60.46, 12.85 in-in-in SNCiii in-in ActLoopNT-in 2.8974 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.73, 153.77 APE9-dihe-na 125.45, -175.95 APE8-dihe-in -101.44, 127.92 APE8-rot-in 301.93 APE67-dihe-inflip 97.46, -21.92 -46.81, 133.28 APE12-dist-in 10.0067 APE11-dist-in 11.2485 APE10-dist-in 5.5344 APE9-dist-in 3.5083 None TPO8 TPO8 XRAY 2.7 0.192 999.0 A 543.0 494.0 0 28 28 0 [[187, 452]] 1.0 3c4w Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4.0 260.0 257.0 331 332 333 335 337 216 235 239 311 313 312 314.0 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C4WB P28327 5 533 561.0 ATP:562 ATPlike Active DFGin 5.9629 13.1113 BLAminus -155.04, 178.49 64.64, 79.84 -103.28, 19.03 277.57, 109.21 -72.3, -19.68 in-in in 8.548 Saltbr-in 2.84 HRD-in -67.79, -54.67 64.69, 11.83 in-in-in SNCiii in-in ActLoopNT-in 2.9583 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.45, 154.48 APE9-dihe-na 126.08, -175.35 APE8-dihe-in -101.18, 126.91 APE8-rot-in 300.91 APE67-dihe-inflip 94.23, -17.08 -47.18, 130.86 APE12-dist-in 10.1029 APE11-dist-in 11.2538 APE10-dist-in 5.5445 APE9-dist-in 3.5342 None TPO8 TPO8 XRAY 2.7 0.192 999.0 B 543.0 519.0 0 28 28 0 [[187, 452]] 1.0 3c4w Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4.0 260.0 257.0 331 332 333 335 337 216 235 239 311 313 312 314.0 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C4XA P28327 30 533 561.0 ATP:562 ATPlike Active DFGin 6.3918 13.2944 BLAminus -153.36, -178.73 56.38, 83.66 -101.23, 19.01 282.86, 141.85 -58.01, -33.04 in-in in 8.6227 Saltbr-in 2.8246 HRD-in -65.41, -52.58 62.44, 13.36 in-in-in SNCiii in-in ActLoopNT-in 2.9597 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -170.48, 144.22 APE9-dihe-na 128.55, -174.69 APE8-dihe-in -103.7, 129.98 APE8-rot-in 314.1 APE67-dihe-inflip 101.04, -22.84 -50.28, 132.61 APE12-dist-in 10.283 APE11-dist-in 11.2374 APE10-dist-in 5.7264 APE9-dist-in 3.8266 None None None XRAY 2.9 0.193 999.0 A 543.0 496.0 0 28 28 0 [[187, 452]] 1.0 3c4x Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4.0 260.0 257.0 331 332 333 335 337 216 235 239 311 313 312 314.0 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C4XB P28327 31 533 561.0 ATP:562 ATPlike Active DFGin 5.9031 13.063 BLAminus -149.62, 174.69 57.3, 76.73 -95.24, 8.98 282.05, 96.12 -51.11, -35.54 in-in in 8.6415 Saltbr-in 2.6755 HRD-in -62.32, -48.48 63.55, 4.44 in-in-in SNCiii in-in ActLoopNT-in 3.0432 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.42, 143.72 APE9-dihe-na 129.46, -175.16 APE8-dihe-in -98.28, 125.3 APE8-rot-in 312.69 APE67-dihe-inflip 98.15, -18.1 -45.11, 129.51 APE12-dist-in 10.2012 APE11-dist-in 11.2468 APE10-dist-in 5.6099 APE9-dist-in 3.6392 None None None XRAY 2.9 0.193 999.0 B 543.0 475.0 0 28 28 0 [[187, 452]] 1.0 3c4x Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4.0 260.0 257.0 331 332 333 335 337 216 235 239 311 313 312 314.0 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC PRKACA KAPCA_BOVIN 9DW9G P00517 13 351 351.0 ATP:401 ATPlike Active DFGin 6.5695 15.1264 BLAminus -133.9, -169.96 59.46, 64.31 -83.85, 33.99 275.29, 73.58 -66.33, -24.36 in-in in 9.4988 Saltbr-in 3.2167 HRD-in -92.3, -53.34 68.25, 14.14 in-in-in SNCiii in-in ActLoopNT-in 3.0799 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.91, 151.76 APE9-dihe-na 126.66, -174.62 APE8-dihe-in -92.84, 130.69 APE8-rot-in 299.41 APE67-dihe-in -68.55, -23.13 -58.33, -34.44 APE12-dist-in 8.7033 APE11-dist-in 11.5632 APE10-dist-in 6.1702 APE9-dist-in 4.5677 None TPO198 TPO198 EM 2.8 999.0 999.0 G 351.0 328.0 0 25 25 0 [[44, 298]] 1.0 9dw9 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1Q24A P00517 15 351 351.0 ATP:60400 ATPlike Active DFGin 5.9832 14.3195 BLAminus -113.95, 178.0 66.86, 85.15 -103.99, 32.82 274.7, 64.8 -65.44, -25.66 in-in in 8.779 Saltbr-in 2.742 HRD-in -93.22, -55.61 73.46, 14.95 in-in-in SNCiii in-in ActLoopNT-in 3.0897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.66, 162.77 APE9-dihe-na 133.15, -143.39 APE8-dihe-in -135.22, 127.61 APE8-rot-in 301.89 APE67-dihe-in -67.43, -30.61 -42.63, -46.05 APE12-dist-in 8.0357 APE11-dist-in 11.4473 APE10-dist-in 6.0235 APE9-dist-in 3.486 V124A,L174M TPO198,SEP339 TPO198,SEP339 XRAY 2.6 0.202 0.25 A 350.0 337.0 0 25 25 0 [[44, 298]] 1.0 1q24 Bos taurus AGC_PRKACA_BOVIN AGC 4.8e-94 320.4 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
OTHER PAN3 PAN3_CHATD 4CYIA G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.5855 12.8524 None -92.38, -13.16 -130.85, 61.75 -94.99, 144.51 286.93, 999.0 79.52, -4.52 out-na out 13.591 Saltbr-na 999.0 HRD-out -83.98, 84.54 -50.92, -35.91 na-out-na SNCaoa out-na ActLoopNT-out 7.062 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -80.88, -42.8 APE9-dihe-na -64.32, -40.93 APE8-dihe-na -99.24, 17.32 APE8-rot-na 300.48 APE67-dihe-na -73.05, -48.17 -58.31, -53.55 APE12-dist-na 4.897 APE11-dist-na 5.5425 APE10-dist-na 5.1047 APE9-dist-na 11.5716 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 A 438.0 405.0 0 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIB G0S0Y3 213 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.6162 12.9181 None -91.62, -15.83 -130.65, 63.54 -94.89, 145.11 286.33, 999.0 77.48, -4.88 out-na out 13.5804 Saltbr-na 999.0 HRD-out -84.8, 85.11 -51.08, -35.56 na-out-na SNCaoa out-na ActLoopNT-out 7.1748 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -82.17, -41.93 APE9-dihe-na -64.26, -40.58 APE8-dihe-na -98.12, 16.28 APE8-rot-na 298.69 APE67-dihe-na 80.12, -45.62 -60.06, 122.74 APE12-dist-na 4.8933 APE11-dist-na 5.4782 APE10-dist-na 5.0793 APE9-dist-na 11.8701 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 B 438.0 406.0 8 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIC G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.4924 12.6474 None -89.83, -13.71 -129.71, 95.5 -125.66, 144.13 285.48, 999.0 76.65, -4.79 out-na out 13.5683 Saltbr-na 999.0 HRD-out -84.9, 84.38 -51.27, -35.99 na-out-na SNCaoa out-na ActLoopNT-out 7.0361 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.46, -42.97 APE9-dihe-na -65.29, -40.87 APE8-dihe-na -98.03, 18.1 APE8-rot-na 300.5 APE67-dihe-na -80.64, -42.62 -57.0, -52.24 APE12-dist-na 4.8695 APE11-dist-na 5.4118 APE10-dist-na 5.1039 APE9-dist-na 11.7021 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 C 438.0 397.0 8 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYID G0S0Y3 214 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.5811 12.83 None -92.56, -14.61 -129.54, 61.33 -91.03, 145.16 286.17, 999.0 78.34, -3.87 out-na out 13.6323 Saltbr-na 999.0 HRD-out -84.73, 84.5 -51.45, -36.17 na-out-na SNCaoa out-na ActLoopNT-out 6.9797 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -82.5, -42.63 APE9-dihe-na -63.84, -39.93 APE8-dihe-na -97.69, 15.27 APE8-rot-na 300.06 APE67-dihe-na 82.88, -51.63 -61.5, 124.95 APE12-dist-na 4.8492 APE11-dist-na 5.59 APE10-dist-na 5.161 APE9-dist-na 11.6129 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 D 438.0 407.0 8 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIE G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.538 12.7667 None -90.87, -14.73 -130.14, 65.48 -95.4, 143.11 286.9, 999.0 77.19, -4.14 out-na out 13.9331 Saltbr-na 999.0 HRD-out -83.54, 85.23 -50.62, -36.04 na-out-na SNCaoa out-na ActLoopNT-out 6.9622 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.29, -42.51 APE9-dihe-na -65.13, -42.05 APE8-dihe-na -99.46, 17.91 APE8-rot-na 300.53 APE67-dihe-na -82.88, -16.1 -58.82, -52.89 APE12-dist-na 4.8671 APE11-dist-na 5.5056 APE10-dist-na 4.9898 APE9-dist-na 11.6524 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 E 438.0 394.0 10 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIF G0S0Y3 213 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.6574 12.9278 None -90.71, -14.62 -131.6, 64.5 -94.2, 145.33 287.42, 999.0 78.97, -5.05 out-na out 13.6193 Saltbr-na 999.0 HRD-out -84.32, 83.81 -51.72, -36.16 na-out-na SNCaoa out-na ActLoopNT-out 7.068 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.37, -43.07 APE9-dihe-na -65.03, -40.26 APE8-dihe-na -97.58, 14.32 APE8-rot-na 301.7 APE67-dihe-na 82.79, -63.67 -61.76, 133.26 APE12-dist-na 4.8968 APE11-dist-na 5.4715 APE10-dist-na 4.9808 APE9-dist-na 11.7452 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 F 438.0 408.0 8 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIG G0S0Y3 212 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.3451 12.7272 None -90.69, -14.9 -130.76, 66.96 -94.98, 143.34 287.45, 999.0 77.29, -3.15 out-na out 13.6864 Saltbr-na 999.0 HRD-out -84.86, 86.26 -50.94, -35.45 na-out-na SNCaoa out-na ActLoopNT-out 6.9562 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.27, -42.88 APE9-dihe-na -64.53, -40.74 APE8-dihe-na -98.57, 20.38 APE8-rot-na 300.7 APE67-dihe-na -82.95, -50.87 -54.99, -52.34 APE12-dist-na 4.8855 APE11-dist-na 5.4414 APE10-dist-na 4.9896 APE9-dist-na 11.838 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 G 438.0 397.0 11 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIH G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.5482 12.9926 None -92.58, -12.35 -130.21, 41.87 -74.5, 144.28 287.27, 999.0 78.55, -5.47 out-na out 13.5649 Saltbr-na 999.0 HRD-out -84.2, 83.95 -50.63, -35.15 na-out-na SNCaoa out-na ActLoopNT-out 7.1131 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.74, -43.44 APE9-dihe-na -64.3, -40.98 APE8-dihe-na -98.31, 13.33 APE8-rot-na 300.84 APE67-dihe-na 84.19, -53.66 -61.5, 130.17 APE12-dist-na 4.8973 APE11-dist-na 5.5511 APE10-dist-na 5.0041 APE9-dist-na 11.6791 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 H 438.0 407.0 7 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJA G0S0Y3 207 630 640.0 ATP:900 ATPlike Pseudo DFGin 8.6339 13.1429 None -107.98, -0.69 -128.2, 34.36 -65.03, -50.53 266.85, 999.0 -67.72, -27.44 out-na out 13.8242 Saltbr-na 999.0 HRD-out -72.25, 117.57 -98.06, -29.9 na-out-na SNCaoa out-na ActLoopNT-out 6.7342 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -76.94, -48.66 APE9-dihe-na -63.83, -32.83 APE8-dihe-na -105.44, 19.22 APE8-rot-na 294.5 APE67-dihe-na -75.63, -42.57 -53.51, -50.74 APE12-dist-na 4.8957 APE11-dist-na 5.5654 APE10-dist-na 4.767 APE9-dist-na 12.0929 None None None XRAY 2.59 0.185 0.221 A 438.0 403.0 9 16 16 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJB G0S0Y3 207 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.6566 13.4069 None -109.51, -3.14 -128.47, 33.06 -65.31, -51.07 267.08, 999.0 -68.09, -25.9 out-na out 13.6072 Saltbr-na 999.0 HRD-out -72.34, 112.57 -93.58, -28.7 na-out-na SNCaoa out-na ActLoopNT-out 6.7399 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.81, -47.86 APE9-dihe-na -64.66, -32.92 APE8-dihe-na -101.7, 13.23 APE8-rot-na 292.51 APE67-dihe-na 83.46, -7.05 -62.34, 118.45 APE12-dist-na 4.8265 APE11-dist-na 5.6867 APE10-dist-na 4.9609 APE9-dist-na 11.8917 None None None XRAY 2.59 0.185 0.221 B 438.0 412.0 10 16 16 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJC G0S0Y3 210 632 640.0 ATP:900 ATPlike Pseudo DFGin 8.6729 13.1643 None -108.29, -3.21 -129.06, 34.16 -64.55, -50.26 267.61, 999.0 -68.23, -27.03 out-na out 13.7221 Saltbr-na 999.0 HRD-out -71.32, 109.68 -92.82, -27.84 na-out-na SNCaoa out-na ActLoopNT-out 6.9283 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -75.12, -48.05 APE9-dihe-na -64.49, -35.42 APE8-dihe-na -104.77, 18.2 APE8-rot-na 294.69 APE67-dihe-na -54.66, -46.82 -53.38, -67.98 APE12-dist-na 4.8857 APE11-dist-na 5.6634 APE10-dist-na 4.9314 APE9-dist-na 11.8945 None None None XRAY 2.59 0.185 0.221 C 438.0 404.0 8 16 16 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJD G0S0Y3 207 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.7302 13.2458 None -109.91, -2.89 -127.7, 32.83 -63.98, -50.83 267.28, 999.0 -68.06, -27.82 out-na out 13.683 Saltbr-na 999.0 HRD-out -71.89, 115.33 -92.98, -30.13 na-out-na SNCaoa out-na ActLoopNT-out 6.6595 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.1, -45.9 APE9-dihe-na -60.82, -48.55 APE8-dihe-na -95.53, 14.82 APE8-rot-na 272.71 APE67-dihe-na -68.99, -42.68 -59.32, -45.4 APE12-dist-na 4.8928 APE11-dist-na 5.6895 APE10-dist-na 4.875 APE9-dist-na 11.9374 None None None XRAY 2.59 0.185 0.221 D 438.0 411.0 11 16 16 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
AGC PRKACA KAPCA_CRIGR 6EMAA P25321 12 351 351.0 ATP:60401 ATPlike Active DFGin 6.8466 14.0282 BLAminus -121.3, 163.01 76.03, 95.19 -107.48, 29.41 285.05, 72.84 -63.27, -23.25 in-in in 8.5805 Saltbr-in 2.9123 HRD-in -88.06, -51.23 73.05, 9.34 in-in-in SNCiii in-in ActLoopNT-in 2.8434 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.85, 162.03 APE9-dihe-na 127.51, -167.2 APE8-dihe-in -113.51, 133.85 APE8-rot-in 299.54 APE67-dihe-in -58.99, -24.47 -49.7, -50.19 APE12-dist-in 8.208 APE11-dist-in 11.4336 APE10-dist-in 5.7768 APE9-dist-in 3.5854 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.88 0.184 0.213 A 353.0 340.0 0 25 25 0 [[44, 298]] 1.0 6ema Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6Y8CA P25321 13 351 351.0 ATP:60402 ATPlike Active DFGin 5.7272 14.3024 BLAminus -123.99, 172.57 69.5, 82.73 -92.15, 25.74 279.44, 63.0 -58.78, -31.82 in-in in 9.1661 Saltbr-in 2.6378 HRD-in -96.49, -52.39 69.1, 12.65 in-in-in SNCiii in-in ActLoopNT-in 2.8845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.28, 160.42 APE9-dihe-na 122.78, -169.96 APE8-dihe-in -106.17, 134.07 APE8-rot-in 304.81 APE67-dihe-in -60.24, -22.7 -48.33, -48.43 APE12-dist-in 8.0442 APE11-dist-in 11.5168 APE10-dist-in 5.9394 APE9-dist-in 3.8952 None TPO198,SEP339 TPO198,SEP339 XRAY 1.76 0.162 0.19 A 353.0 339.0 0 25 25 0 [[44, 298]] 1.0 6y8c Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC GRK5 GRK5_HUMAN 9CKRA P34947 25 542 590.0 ATP:603 ATPlike Active DFGin 6.1719 12.8672 BLAminus -123.04, 159.77 67.48, 80.75 -99.52, 5.04 278.7, 83.61 -52.63, -21.44 in-in in 8.5891 Saltbr-in 3.447 HRD-in -94.88, -52.49 68.7, 5.59 in-in-in SNCiii in-in ActLoopNT-in 2.9677 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.66, 167.59 APE9-dihe-na 129.66, -152.54 APE8-dihe-in -119.66, 138.17 APE8-rot-in 320.31 APE67-dihe-inflip 80.19, -6.12 -54.38, 134.58 APE12-dist-in 9.8722 APE11-dist-in 12.2584 APE10-dist-in 6.5289 APE9-dist-in 4.1807 D311N None None XRAY 2.8 0.239 0.286 A 598.0 501.0 0 27 27 0 [[186, 448]] 1.0 9ckr Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9CKSA P34947 25 542 590.0 ATP:603 ATPlike Active DFGin 6.0382 13.0612 BLAminus -123.04, 167.6 79.98, 56.79 -87.17, 17.84 285.5, 62.72 -70.38, -31.79 in-in in 9.2222 Saltbr-in 2.6724 HRD-in -92.29, -53.7 68.73, 3.48 in-in-in SNCiii in-in ActLoopNT-in 2.9627 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.24, 151.24 APE9-dihe-na 138.17, -158.29 APE8-dihe-in -117.35, 145.2 APE8-rot-in 310.61 APE67-dihe-inflip 85.98, -22.04 -53.6, 135.84 APE12-dist-in 10.6156 APE11-dist-in 12.4068 APE10-dist-in 6.5628 APE9-dist-in 4.2067 D311N None None XRAY 3.08 0.228 0.28 A 598.0 501.0 0 27 27 0 [[186, 448]] 1.0 9cks Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1.0 260.0 260.0 328 329 330 332 334 215 234 238 308 310 309 311.0 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC PDPK1 PDPK1_HUMAN 1H1WA O15530 71 359 556.0 ATP:1373 ATPlike Inactive DFGin 6.6116 14.931 BLAminus -145.26, -169.97 71.92, 72.18 -105.82, -0.04 289.27, 102.08 -58.33, -31.92 in-in in 8.5808 Saltbr-in 2.7103 HRD-in -71.45, -48.32 74.08, -8.04 in-in-out SNCiio in-out ActLoopNT-in 2.8395 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -131.69, 112.94 APE9-dihe-na -63.98, -168.66 APE8-dihe-in -54.13, 124.0 APE8-rot-in 301.59 APE67-dihe-in -62.54, -19.03 -38.83, -50.46 APE12-dist-in 8.922 APE11-dist-out 5.528 APE10-dist-out 10.2978 APE9-dist-in 3.7994 None SEP241 SEP241 XRAY 2.0 0.196 0.223 A 289.0 285.0 4 30 26 4 [[82, 342]] 1.0 1h1w Homo sapiens AGC_PDPK1_HUMAN AGC 9.8e-85 289.7 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 2BIYA O15530 72 359 556.0 ATP:1373 ATPlike Active DFGin 6.6186 15.0949 BLAminus -141.33, -175.84 82.91, 67.67 -104.99, 1.58 283.05, 104.18 -61.63, -33.06 in-in in 8.6731 Saltbr-in 2.5745 HRD-in -63.52, -52.73 78.44, -11.09 in-in-in SNCiii in-in ActLoopNT-in 2.8201 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -88.22, 130.12 APE9-dihe-na 106.71, 171.13 APE8-dihe-in -96.94, 126.07 APE8-rot-in 299.07 APE67-dihe-in -62.15, -19.51 -52.23, -44.36 APE12-dist-in 12.8679 APE11-dist-in 12.8691 APE10-dist-in 7.2677 APE9-dist-in 4.7446 S241A None None XRAY 1.95 0.186 0.23 A 310.0 288.0 0 30 30 0 [[82, 342]] 1.0 2biy Homo sapiens AGC_PDPK1_HUMAN AGC 1.8e-84 288.8 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3HRCA O15530 76 359 556.0 ATP:1373 ATPlike Active DFGin 6.4861 14.8331 BLAminus -136.91, -178.17 71.81, 74.55 -104.54, 6.98 286.89, 102.51 -65.47, -24.41 in-in in 8.4211 Saltbr-in 3.1591 HRD-in -77.24, -54.93 76.93, -11.42 in-in-in SNCiii in-in ActLoopNT-in 2.87 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.25, 162.0 APE9-dihe-na 130.63, -171.63 APE8-dihe-in -125.01, 129.68 APE8-rot-in 292.48 APE67-dihe-in -58.92, -25.29 -45.32, -48.7 APE12-dist-in 7.4085 APE11-dist-in 10.582 APE10-dist-in 4.9259 APE9-dist-in 3.4793 Y288G,Q292A SEP241 SEP241 XRAY 1.91 0.182 0.207 A 311.0 280.0 4 30 26 4 [[82, 342]] 1.0 3hrc Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4RRVA O15530 76 359 556.0 ATP:60401 ATPlike Active DFGin 6.5481 14.9984 BLAminus -136.55, -175.99 74.63, 72.8 -106.52, 5.78 286.61, 100.18 -68.12, -17.88 in-in in 8.5198 Saltbr-in 2.956 HRD-in -71.77, -54.29 78.75, -11.73 in-in-in SNCiii in-in ActLoopNT-in 2.9375 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.13, 162.83 APE9-dihe-na 132.08, -169.67 APE8-dihe-in -127.24, 132.02 APE8-rot-in 298.33 APE67-dihe-in -59.21, -24.3 -51.83, -46.04 APE12-dist-in 7.2806 APE11-dist-in 10.5025 APE10-dist-in 4.943 APE9-dist-in 3.5694 Y288G,Q292A SEP241 SEP241 XRAY 1.412 0.135 0.163 A 311.0 284.0 0 30 30 0 [[82, 342]] 1.0 4rrv Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5ACKA O15530 73 359 556.0 ATP:500 ATPlike Active DFGin 6.6153 14.8606 BLAminus -135.34, 179.84 72.22, 79.01 -106.01, 4.14 287.93, 97.64 -67.02, -18.73 in-in in 8.4184 Saltbr-in 2.5825 HRD-in -74.68, -53.67 78.01, -12.73 in-in-in SNCiii in-in ActLoopNT-in 2.9064 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.4, 162.51 APE9-dihe-na 136.44, -168.07 APE8-dihe-in -132.35, 133.52 APE8-rot-in 296.36 APE67-dihe-in -62.96, -23.95 -54.34, -43.19 APE12-dist-in 7.3257 APE11-dist-in 10.5222 APE10-dist-in 4.9779 APE9-dist-in 3.5575 Y288G,Q292A SEP241 SEP241 XRAY 1.24 0.143 0.166 A 311.0 287.0 0 30 30 0 [[82, 342]] 1.0 5ack Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVPA O15530 75 359 556.0 ATP:500 ATPlike Active DFGin 6.3028 14.9979 BLAminus -144.92, -168.82 66.06, 77.78 -108.23, 11.17 281.99, 93.22 -63.04, -32.41 in-in in 9.539 Saltbr-in 3.1581 HRD-in -77.47, -51.83 79.92, -12.48 in-in-in SNCiii in-in ActLoopNT-in 2.8481 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.64, 166.02 APE9-dihe-na 141.61, 177.5 APE8-dihe-in -123.02, 134.29 APE8-rot-in 296.02 APE67-dihe-in -68.65, -16.53 -46.89, -50.92 APE12-dist-in 7.9068 APE11-dist-in 10.6706 APE10-dist-in 5.166 APE9-dist-in 3.7049 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 A 311.0 276.0 9 30 21 9 [[82, 342]] 1.0 5lvp Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVPB O15530 74 359 556.0 ATP:401 ATPlike Active DFGin 6.3283 14.5498 BLAminus -137.23, -179.71 80.14, 74.16 -105.47, 15.38 295.0, 84.83 -59.91, -31.47 in-in in 9.2741 Saltbr-in 3.3024 HRD-in -80.68, -44.41 73.96, -16.23 in-in-in SNCiii in-in ActLoopNT-in 2.7443 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.8, 152.43 APE9-dihe-na 134.43, -173.75 APE8-dihe-in -120.09, 128.28 APE8-rot-in 302.93 APE67-dihe-in -67.56, -25.72 -44.99, -47.55 APE12-dist-in 7.8719 APE11-dist-in 11.0112 APE10-dist-in 5.3751 APE9-dist-in 3.7868 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 B 311.0 277.0 9 30 21 9 [[82, 342]] 1.0 5lvp Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVPC O15530 75 359 556.0 ATP:401 ATPlike Active DFGin 6.3906 14.6076 BLAminus -132.15, -176.81 71.98, 84.02 -116.53, 7.62 291.47, 90.46 -60.24, -24.5 in-in in 9.3044 Saltbr-in 3.0866 HRD-in -75.92, -52.06 78.45, -5.49 in-in-in SNCiii in-in ActLoopNT-in 2.8228 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.81, 168.64 APE9-dihe-na 131.92, -176.79 APE8-dihe-in -126.79, 133.21 APE8-rot-in 299.13 APE67-dihe-in -67.64, -15.8 -51.62, -50.49 APE12-dist-in 7.6523 APE11-dist-in 10.8632 APE10-dist-in 5.1235 APE9-dist-in 3.6447 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 C 311.0 276.0 9 30 21 9 [[82, 342]] 1.0 5lvp Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVPD O15530 74 359 556.0 ATP:500 ATPlike Active DFGin 6.3336 14.4328 BLAminus -146.99, -174.22 74.22, 81.56 -113.84, 4.02 287.97, 93.59 -56.11, -25.73 in-in in 9.3044 Saltbr-in 3.2517 HRD-in -82.38, -50.18 78.4, -12.51 in-in-in SNCiii in-in ActLoopNT-in 2.8357 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.65, 165.17 APE9-dihe-na 129.1, -166.82 APE8-dihe-in -132.84, 129.79 APE8-rot-in 300.06 APE67-dihe-in -65.46, -17.03 -48.9, -48.47 APE12-dist-in 8.2282 APE11-dist-in 10.8909 APE10-dist-in 5.3485 APE9-dist-in 3.6459 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 D 311.0 277.0 9 30 21 9 [[82, 342]] 1.0 5lvp Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4CT2A O15530 75 359 556.0 ATP:500 ATPlike Active DFGin 6.5509 14.8668 BLAminus -136.23, -174.98 70.54, 70.07 -102.02, 6.41 290.69, 95.78 -63.73, -21.59 in-in in 8.2523 Saltbr-in 2.6427 HRD-in -73.2, -54.84 77.37, -9.78 in-in-in SNCiii in-in ActLoopNT-in 2.9649 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.02, 163.59 APE9-dihe-na 137.39, -170.05 APE8-dihe-in -132.12, 131.72 APE8-rot-in 295.26 APE67-dihe-in -63.06, -17.27 -51.84, -45.87 APE12-dist-in 7.1628 APE11-dist-in 10.5242 APE10-dist-in 4.9787 APE9-dist-in 3.5273 L113V,I118V,I119H,V124I,T128Q,R131K,T148C,F157L,Y288G,Q292A SEP241 SEP241 XRAY 1.25 0.194 0.226 A 311.0 280.0 5 30 30 0 [[82, 342]] 1.0 4ct2 Homo sapiens AGC_PDPK1_HUMAN AGC 9.5e-84 286.4 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5MRDA O15530 76 359 556.0 ATP:405 ATPlike Active DFGin 6.4288 14.7004 BLAminus -133.69, -177.11 74.21, 73.9 -105.88, 9.0 289.39, 99.64 -68.32, -19.62 in-in in 8.3463 Saltbr-in 2.6673 HRD-in -74.32, -53.19 77.26, -10.58 in-in-in SNCiii in-in ActLoopNT-in 2.9416 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.86, 160.68 APE9-dihe-na 136.11, -166.87 APE8-dihe-in -131.1, 132.63 APE8-rot-in 296.36 APE67-dihe-in -62.36, -23.28 -53.02, -44.84 APE12-dist-in 7.3524 APE11-dist-in 10.4975 APE10-dist-in 4.9095 APE9-dist-in 3.5424 K76S,L113V,I118V,I119N,V124I,T128Q,R131K,T148C SEP241 SEP241 XRAY 1.41 0.142 0.174 A 310.0 284.0 0 30 30 0 [[82, 342]] 1.0 5mrd Homo sapiens AGC_PDPK1_HUMAN AGC 1.7e-83 285.6 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3HRFA O15530 75 359 556.0 ATP:1373,P47:1374 ATPlike,Allosteric Active DFGin 6.5137 14.7842 BLAminus -133.77, -176.11 75.25, 77.12 -110.83, 6.58 287.55, 100.98 -63.85, -22.79 in-in in 8.3869 Saltbr-in 2.7006 HRD-in -73.67, -53.98 76.59, -10.73 in-in-in SNCiii in-in ActLoopNT-in 2.9232 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.42, 166.15 APE9-dihe-na 124.75, -165.6 APE8-dihe-in -127.97, 128.5 APE8-rot-in 295.31 APE67-dihe-in -62.28, -24.12 -44.34, -47.42 APE12-dist-in 7.3513 APE11-dist-in 10.5457 APE10-dist-in 4.8669 APE9-dist-in 3.4806 Y288G,Q292A SEP241 SEP241 XRAY 1.9 0.165 0.177 A 311.0 285.0 0 30 30 0 [[82, 342]] 1.0 3hrf Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4A06A O15530 75 359 556.0 ATP:500,A06:600 ATPlike,Allosteric Active DFGin 6.5121 14.757 BLAminus -135.73, -177.17 74.25, 74.67 -110.25, 11.82 284.97, 101.73 -68.23, -22.46 in-in in 8.3192 Saltbr-in 2.8636 HRD-in -73.73, -51.84 74.62, -10.07 in-in-in SNCiii in-in ActLoopNT-in 2.9204 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.65, 165.25 APE9-dihe-na 128.95, -173.35 APE8-dihe-in -120.15, 131.51 APE8-rot-in 299.31 APE67-dihe-in -59.46, -27.29 -45.75, -47.91 APE12-dist-in 7.336 APE11-dist-in 10.4473 APE10-dist-in 4.8734 APE9-dist-in 3.5088 Y288G,Q292A SEP241 SEP241 XRAY 2.0 0.161 0.198 A 311.0 285.0 0 30 30 0 [[82, 342]] 1.0 4a06 Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4AW0A O15530 75 359 556.0 ATP:500,MJF:600 ATPlike,Allosteric Active DFGin 6.5313 14.9926 BLAminus -134.84, 177.25 78.73, 76.19 -106.3, 8.53 283.51, 97.11 -69.63, -19.36 in-in in 8.5954 Saltbr-in 3.0091 HRD-in -83.05, -53.03 79.45, -12.94 in-in-in SNCiii in-in ActLoopNT-in 2.9336 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.69, 159.04 APE9-dihe-na 139.48, -167.8 APE8-dihe-in -131.87, 132.42 APE8-rot-in 295.45 APE67-dihe-in -61.29, -25.28 -54.74, -42.17 APE12-dist-in 7.5089 APE11-dist-in 10.6011 APE10-dist-in 5.0264 APE9-dist-in 3.5797 Y288G,Q292A SEP241 SEP241,CME260 XRAY 1.43 0.171 0.188 A 311.0 285.0 0 30 30 0 [[82, 342]] 1.0 4aw0 Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4AW1A O15530 66 359 556.0 ATP:1360,21O:1361 ATPlike,Allosteric Active DFGin 6.325 14.155 BLAminus -137.24, -178.23 68.96, 84.69 -105.37, 17.06 286.01, 86.79 -62.77, -26.7 in-in in 8.5758 Saltbr-in 2.8639 HRD-in -81.18, -54.06 78.32, -13.29 in-in-in SNCiii in-in ActLoopNT-in 2.8487 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.98, 160.2 APE9-dihe-na 130.22, -162.57 APE8-dihe-in -126.98, 128.72 APE8-rot-in 295.96 APE67-dihe-in -57.45, -24.35 -48.01, -47.7 APE12-dist-in 7.6532 APE11-dist-in 10.8523 APE10-dist-in 5.0751 APE9-dist-in 3.5856 Y288G,Q292A SEP241 SEP241 XRAY 1.68 0.165 0.186 A 311.0 287.0 5 30 25 5 [[82, 342]] 1.0 4aw1 Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4RQKA O15530 74 359 556.0 ATP:403,R1S:404 ATPlike,Allosteric Active DFGin 6.4608 14.7857 BLAminus -139.06, -177.03 75.27, 72.83 -105.25, 7.36 287.3, 98.33 -64.7, -21.38 in-in in 8.4643 Saltbr-in 2.9412 HRD-in -73.98, -52.31 74.79, -9.31 in-in-in SNCiii in-in ActLoopNT-in 2.8799 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.64, 164.69 APE9-dihe-na 126.87, -171.23 APE8-dihe-in -124.75, 130.48 APE8-rot-in 298.57 APE67-dihe-in -59.79, -23.66 -48.31, -47.88 APE12-dist-in 7.2437 APE11-dist-in 10.4657 APE10-dist-in 4.9176 APE9-dist-in 3.5437 Y288G,Q292A SEP241 SEP241 XRAY 1.55 0.133 0.167 A 311.0 286.0 0 30 30 0 [[82, 342]] 1.0 4rqk Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4RQVA O15530 71 359 556.0 ATP:405,R2S:406 ATPlike,Allosteric Active DFGin 6.4916 14.9536 BLAminus -139.41, -174.88 74.87, 69.78 -102.0, 7.85 285.85, 94.73 -65.11, -21.56 in-in in 8.2557 Saltbr-in 2.7717 HRD-in -72.94, -52.57 74.87, -10.5 in-in-in SNCiii in-in ActLoopNT-in 2.9156 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.07, 164.19 APE9-dihe-na 130.69, -171.7 APE8-dihe-in -126.67, 130.74 APE8-rot-in 297.63 APE67-dihe-in -61.47, -23.77 -49.17, -46.26 APE12-dist-in 7.2532 APE11-dist-in 10.4876 APE10-dist-in 4.9687 APE9-dist-in 3.5133 Y288G,Q292A SEP241 SEP241 XRAY 1.502 0.133 0.166 A 311.0 289.0 0 30 30 0 [[82, 342]] 1.0 4rqv Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVOA O15530 73 359 556.0 ATP:401,78W:402 ATPlike,Allosteric Active DFGin 6.581 15.0047 BLAminus -134.78, 179.9 79.12, 70.17 -103.55, 0.25 286.72, 100.66 -64.63, -19.63 in-in in 8.5884 Saltbr-in 2.6313 HRD-in -71.89, -54.41 77.65, -9.82 in-in-in SNCiii in-in ActLoopNT-in 2.9194 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.78, 162.52 APE9-dihe-na 134.75, -167.11 APE8-dihe-in -130.46, 134.12 APE8-rot-in 296.12 APE67-dihe-in -62.26, -22.94 -53.92, -45.37 APE12-dist-in 7.4502 APE11-dist-in 10.5584 APE10-dist-in 4.9836 APE9-dist-in 3.5527 Y288G,Q292A SEP241 SEP241 XRAY 1.09 0.136 0.157 A 311.0 287.0 0 30 30 0 [[82, 342]] 1.0 5lvo Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4CT1A O15530 76 359 556.0 ATP:500,31S:600 ATPlike,Allosteric None DFGin 6.6022 14.9785 BLAminus -141.71, -172.51 72.43, 72.08 -107.06, 8.07 284.9, 97.13 -62.67, -20.12 in-none in 8.1463 Saltbr-none 999.0 HRD-in -74.62, -54.47 79.43, -8.97 none-in-in SNCnii in-in ActLoopNT-in 2.9992 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.29, 160.89 APE9-dihe-na 137.85, -171.95 APE8-dihe-in -126.26, 129.35 APE8-rot-in 296.2 APE67-dihe-in -61.08, -24.26 -47.64, -46.5 APE12-dist-in 7.3566 APE11-dist-in 10.4885 APE10-dist-in 5.0182 APE9-dist-in 3.4798 L113V,I118V,I119H,V124I,T128Q,R131K,T148C,F157L,Y288G,Q292A SEP241 SEP241 XRAY 1.85 0.172 0.215 A 311.0 284.0 0 30 30 0 [[82, 342]] 1.0 4ct1 Homo sapiens AGC_PDPK1_HUMAN AGC 9.5e-84 286.4 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4XX9A O15530 71 359 556.0 ATP:401,RF4:402,RF4:403 ATPlike,Allosteric,Allosteric Active DFGin 6.5134 14.9881 BLAminus -138.47, -176.21 74.83, 73.76 -104.66, 7.86 282.59, 98.49 -68.99, -20.43 in-in in 8.4422 Saltbr-in 2.9225 HRD-in -73.71, -50.51 73.32, -9.3 in-in-in SNCiii in-in ActLoopNT-in 2.8949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.41, 162.37 APE9-dihe-na 129.79, -167.49 APE8-dihe-in -129.09, 132.1 APE8-rot-in 295.95 APE67-dihe-in -59.66, -23.23 -49.94, -47.34 APE12-dist-in 7.3717 APE11-dist-in 10.5754 APE10-dist-in 4.9467 APE9-dist-in 3.5452 Y288G,Q292A SEP241 SEP241 XRAY 1.4 0.13 0.165 A 310.0 289.0 0 30 30 0 [[82, 342]] 1.0 4xx9 Homo sapiens AGC_PDPK1_HUMAN AGC 6.8e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4A07A O15530 75 359 556.0 ATP:500,AZ7:600,AZ7:700 ATPlike,Allosteric,Allosteric Active DFGin 6.6546 14.7523 BLAminus -135.35, -178.9 76.01, 72.4 -108.94, 8.63 286.31, 98.68 -64.37, -21.88 in-in in 8.6213 Saltbr-in 2.919 HRD-in -76.19, -54.82 80.07, -12.14 in-in-in SNCiii in-in ActLoopNT-in 2.9107 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.16, 162.52 APE9-dihe-na 132.15, -164.48 APE8-dihe-in -133.89, 130.56 APE8-rot-in 295.87 APE67-dihe-in -62.13, -24.83 -47.31, -46.9 APE12-dist-in 7.3216 APE11-dist-in 10.4272 APE10-dist-in 4.9977 APE9-dist-in 3.5816 Y288G,Q292A SEP241 SEP241,CSS260 XRAY 1.85 0.161 0.2 A 311.0 285.0 0 30 30 0 [[82, 342]] 1.0 4a07 Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1.0 260.0 260.0 222 223 224 226 228 111 130 134 202 204 203 205.0 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PRKACA KAPCA_HUMAN 4WB8A P17612 16 351 351.0 ATP:60401 ATPlike Active DFGin 5.6838 14.4142 BLAminus -121.45, -177.2 62.67, 77.75 -91.98, 24.58 268.87, 53.09 -58.34, -31.51 in-in in 8.9131 Saltbr-in 2.7592 HRD-in -95.2, -52.32 70.44, 11.38 in-in-in SNCiii in-in ActLoopNT-in 2.9124 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.85, 164.58 APE9-dihe-na 131.46, -156.38 APE8-dihe-in -129.55, 139.43 APE8-rot-in 297.11 APE67-dihe-in -60.54, -22.69 -52.03, -49.04 APE12-dist-in 8.0978 APE11-dist-in 11.3919 APE10-dist-in 5.8266 APE9-dist-in 3.4975 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.55 0.164 0.184 A 337.0 336.0 0 25 25 0 [[44, 298]] 1.0 4wb8 Homo sapiens AGC_PRKACA_HUMAN AGC 4e-95 323.8 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB5A P17612 14 351 351.0 ATP:60401 ATPlike Active DFGin 5.5996 14.452 BLAminus -123.05, 176.84 68.94, 80.02 -91.46, 24.86 270.2, 52.92 -60.74, -31.43 in-in in 9.0296 Saltbr-in 2.7148 HRD-in -92.12, -52.84 69.8, 13.37 in-in-in SNCiii in-in ActLoopNT-in 2.9178 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.48, 163.75 APE9-dihe-na 132.31, -149.49 APE8-dihe-in -132.05, 134.14 APE8-rot-in 301.14 APE67-dihe-in -60.1, -21.12 -48.44, -50.23 APE12-dist-in 8.0121 APE11-dist-in 11.4001 APE10-dist-in 5.799 APE9-dist-in 3.5673 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.641 0.165 0.196 A 350.0 338.0 0 25 25 0 [[44, 298]] 1.0 4wb5 Homo sapiens AGC_PRKACA_HUMAN AGC 4.5e-95 323.7 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6NO7E P17612 13 351 351.0 ATP:60403 ATPlike Inactive DFGin 6.9335 14.1655 BLAminus -118.71, 175.9 64.55, 75.01 -86.85, 19.7 273.68, 51.02 -43.49, -41.12 in-out in 9.4189 Saltbr-out 5.4559 HRD-in -91.66, -53.62 73.72, 11.47 out-in-in SNCoii in-in ActLoopNT-in 3.1639 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.9, 150.23 APE9-dihe-na 149.21, -142.3 APE8-dihe-in -132.1, 131.95 APE8-rot-in 297.19 APE67-dihe-in -64.62, -25.64 -37.25, -53.79 APE12-dist-in 8.0557 APE11-dist-in 10.9843 APE10-dist-in 5.7482 APE9-dist-in 3.2156 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.55 0.259 0.269 E 350.0 339.0 0 25 25 0 [[44, 298]] 1.0 6no7 Homo sapiens AGC_PRKACA_HUMAN AGC 4.5e-95 323.7 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6NO7G P17612 15 351 351.0 ATP:60403 ATPlike Inactive DFGin 6.0359 14.0844 BLAminus -118.68, 176.55 65.34, 76.32 -85.78, 18.75 273.72, 51.07 -44.34, -41.82 in-out in 9.7125 Saltbr-out 5.2149 HRD-in -91.95, -53.38 74.11, 11.57 out-in-in SNCoii in-in ActLoopNT-in 3.3017 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.42, 149.81 APE9-dihe-na 148.91, -142.4 APE8-dihe-in -132.18, 131.68 APE8-rot-in 297.12 APE67-dihe-in -64.98, -25.0 -37.42, -54.32 APE12-dist-in 7.6679 APE11-dist-in 10.658 APE10-dist-in 5.5534 APE9-dist-in 3.4096 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.55 0.259 0.269 G 350.0 337.0 0 25 25 0 [[44, 298]] 1.0 6no7 Homo sapiens AGC_PRKACA_HUMAN AGC 4.5e-95 323.7 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB7A P17612 2 351 351.0 ATP:60501 ATPlike Active DFGin 5.4448 14.6485 BLAminus -119.06, -174.39 59.4, 77.28 -89.09, 26.42 267.74, 51.48 -60.48, -28.34 in-in in 8.8699 Saltbr-in 2.7695 HRD-in -93.55, -50.9 68.82, 8.95 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.63, 158.06 APE9-dihe-na 139.02, -156.91 APE8-dihe-in -126.94, 137.23 APE8-rot-in 299.54 APE67-dihe-in -64.26, -23.0 -50.4, -48.13 APE12-dist-in 8.1804 APE11-dist-in 11.5397 APE10-dist-in 5.9545 APE9-dist-in 3.7228 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.9 0.152 0.188 A 405.0 336.0 0 25 25 0 [[44, 298]] 1.0 4wb7 Homo sapiens AGC_PRKACA_HUMAN AGC 7e-95 323.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB7B P17612 2 351 351.0 ATP:60501 ATPlike Active DFGin 5.3799 14.7121 BLAminus -115.93, -176.79 62.38, 75.33 -88.91, 25.18 264.71, 51.71 -56.9, -30.26 in-in in 8.9624 Saltbr-in 2.7732 HRD-in -94.01, -50.55 67.24, 10.48 in-in-in SNCiii in-in ActLoopNT-in 2.9391 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.07, 161.39 APE9-dihe-na 132.31, -156.17 APE8-dihe-in -127.2, 138.18 APE8-rot-in 298.14 APE67-dihe-in -59.62, -23.37 -52.63, -48.78 APE12-dist-in 8.1977 APE11-dist-in 11.5627 APE10-dist-in 5.9704 APE9-dist-in 3.6419 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.9 0.152 0.188 B 405.0 336.0 0 25 25 0 [[44, 298]] 1.0 4wb7 Homo sapiens AGC_PRKACA_HUMAN AGC 7e-95 323.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6BYRA P17612 2 351 351.0 ATP:60501 ATPlike Active DFGin 5.6263 14.6159 BLAminus -128.29, 177.03 62.06, 86.64 -97.54, 28.59 271.87, 66.62 -63.2, -33.23 in-in in 8.8079 Saltbr-in 3.1965 HRD-in -87.43, -52.47 67.28, 5.18 in-in-in SNCiii in-in ActLoopNT-in 3.1931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.51, 153.24 APE9-dihe-na 149.32, -133.8 APE8-dihe-in -139.35, 133.91 APE8-rot-in 312.31 APE67-dihe-in -68.4, -6.95 -52.73, -48.25 APE12-dist-in 8.7341 APE11-dist-in 11.0763 APE10-dist-in 5.6298 APE9-dist-in 3.4915 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.661 0.203 0.249 A 405.0 336.0 0 25 25 0 [[44, 298]] 1.0 6byr Homo sapiens AGC_PRKACA_HUMAN AGC 7e-95 323.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6BYRC P17612 2 351 351.0 ATP:60501 ATPlike Active DFGin 5.6794 14.3401 BLAminus -129.89, 172.29 61.76, 74.25 -79.2, 34.93 281.69, 54.14 -61.8, -27.34 in-in in 8.7335 Saltbr-in 2.4981 HRD-in -93.13, -49.8 64.55, 7.44 in-in-in SNCiii in-in ActLoopNT-in 3.0524 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.29, 161.94 APE9-dihe-na 130.51, -156.26 APE8-dihe-in -112.31, 134.09 APE8-rot-in 302.07 APE67-dihe-in -64.15, -16.52 -52.64, -41.39 APE12-dist-in 8.3162 APE11-dist-in 11.1062 APE10-dist-in 5.7667 APE9-dist-in 3.6182 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.661 0.203 0.249 C 405.0 336.0 0 25 25 0 [[44, 298]] 1.0 6byr Homo sapiens AGC_PRKACA_HUMAN AGC 7e-95 323.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 9EDCA P17612 14 351 351.0 ATP:60400 ATPlike Active DFGin 5.6262 13.772 BLAminus -125.61, -173.52 60.53, 69.6 -81.59, 16.86 273.36, 51.23 -62.38, -30.28 in-in in 9.1286 Saltbr-in 2.9998 HRD-in -112.54, -46.7 65.17, 1.82 in-in-in SNCiii in-in ActLoopNT-in 3.1404 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.87, 159.92 APE9-dihe-na 136.42, -156.18 APE8-dihe-in -101.13, 126.83 APE8-rot-in 299.98 APE67-dihe-in -84.76, -8.6 -60.74, -28.35 APE12-dist-in 7.9989 APE11-dist-in 11.1115 APE10-dist-in 5.7968 APE9-dist-in 3.7475 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 EM 4.18 999.0 999.0 A 350.0 338.0 0 25 25 0 [[44, 298]] 1.0 9edc Homo sapiens AGC_PRKACA_HUMAN AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 9EDDA P17612 14 351 351.0 ATP:60400 ATPlike Inactive DFGin 7.6417 15.4797 BLAminus -131.38, -176.44 56.47, 73.0 -86.17, 32.62 269.53, 53.11 -62.17, -29.29 in-out in 9.6174 Saltbr-out 3.9466 HRD-in -100.83, -51.39 64.03, -2.2 out-out-out SNCooo out-out ActLoopNT-out 3.7028 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.87, 141.16 APE9-dihe-na 150.41, -172.01 APE8-dihe-in -103.27, 147.74 APE8-rot-out 185.24 APE67-dihe-in -92.0, 3.92 -57.96, -27.57 APE12-dist-in 8.1647 APE11-dist-in 11.2754 APE10-dist-in 5.6275 APE9-dist-in 4.2273 None TPO198,SEP339 TPO198,SEP339 EM 6.3 999.0 999.0 A 350.0 338.0 0 25 25 0 [[44, 298]] 1.0 9edd Homo sapiens AGC_PRKACA_HUMAN AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 9EDEA P17612 14 351 351.0 ATP:60400 ATPlike Inactive DFGin 6.6922 15.188 BLAminus -131.57, -176.8 59.06, 65.59 -87.14, 28.49 267.05, 50.71 -66.29, -36.64 in-out in 9.9219 Saltbr-out 4.6819 HRD-in -115.21, -49.18 64.38, 4.15 out-out-out SNCooo out-out ActLoopNT-out 3.632 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -122.67, 141.1 APE9-dihe-na 158.89, -177.66 APE8-dihe-in -75.58, 154.98 APE8-rot-out 190.35 APE67-dihe-in -109.16, -25.21 -65.33, -8.36 APE12-dist-in 8.3471 APE11-dist-in 11.7825 APE10-dist-in 6.8289 APE9-dist-in 4.9175 None TPO198,SEP339 TPO198,SEP339 EM 5.9 999.0 999.0 A 350.0 338.0 0 25 25 0 [[44, 298]] 1.0 9ede Homo sapiens AGC_PRKACA_HUMAN AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB6A P17612 14 351 351.0 ATP:60401 ATPlike Active DFGin 6.0678 14.3977 BLAminus -118.38, -169.49 51.77, 82.47 -95.61, 17.78 271.18, 55.73 -42.8, -37.29 in-in in 8.8304 Saltbr-in 2.5613 HRD-in -94.17, -52.18 74.17, 2.46 in-in-in SNCiii in-in ActLoopNT-in 2.9483 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.55, 166.68 APE9-dihe-na 116.18, 128.45 APE8-dihe-in -46.62, 128.74 APE8-rot-in 303.5 APE67-dihe-in -58.01, -23.74 -49.09, -50.89 APE12-dist-in 8.0462 APE11-dist-in 11.764 APE10-dist-in 6.2427 APE9-dist-in 3.7665 L206R SEP11,SEP140,TPO198 SEP11,SEP140,TPO198 XRAY 2.1 0.19 0.237 A 350.0 338.0 0 25 25 0 [[44, 298]] 1.0 4wb6 Homo sapiens AGC_PRKACA_HUMAN AGC 8.6e-94 319.5 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB6B P17612 9 351 351.0 ATP:60401 ATPlike Active DFGin 5.8721 14.0727 BLAminus -117.82, -168.32 53.27, 78.35 -91.25, 29.34 274.97, 62.46 -60.26, -35.85 in-in in 8.6873 Saltbr-in 2.7501 HRD-in -101.62, -46.5 64.42, 3.48 in-in-in SNCiii in-in ActLoopNT-in 2.9461 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.38, 164.15 APE9-dihe-na 120.83, 133.18 APE8-dihe-in -48.66, 125.41 APE8-rot-in 298.86 APE67-dihe-in -54.58, -37.6 -53.55, -42.52 APE12-dist-in 8.078 APE11-dist-in 11.6173 APE10-dist-in 6.2035 APE9-dist-in 3.8221 L206R SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.1 0.19 0.237 B 350.0 343.0 0 25 25 0 [[44, 298]] 1.0 4wb6 Homo sapiens AGC_PRKACA_HUMAN AGC 8.6e-94 319.5 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKCI KPCI_HUMAN 3A8WA P41743 249 588 596.0 ATP:60601 ATPlike Inactive DFGin 5.1739 12.3776 BLAminus -132.69, 170.49 67.34, 88.86 -96.11, 11.96 304.5, 130.94 -60.46, -20.34 in-out in 8.3565 Saltbr-out 3.8823 HRD-in -61.87, -57.79 75.89, -1.36 out-in-in SNCoii in-in ActLoopNT-in 2.7712 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.32, 177.7 APE9-dihe-na 120.34, -178.18 APE8-dihe-in -99.49, 131.04 APE8-rot-in 301.47 APE67-dihe-in -55.52, -25.65 -39.88, -56.62 APE12-dist-in 8.7688 APE11-dist-in 11.7671 APE10-dist-in 6.2593 APE9-dist-in 3.6656 None TPO412,TPO564 TPO412,TPO564 XRAY 2.1 0.25 0.301 A 345.0 325.0 15 28 28 0 [[254, 522]] 1.0 3a8w Homo sapiens AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 3A8WB P41743 249 588 596.0 ATP:60601 ATPlike Inactive DFGin 5.2569 12.3236 BLAminus -133.61, 172.63 64.84, 89.8 -97.52, 11.0 299.58, 138.75 -72.95, 35.24 in-out in 8.1924 Saltbr-out 3.9771 HRD-in -61.03, -56.18 70.75, 8.33 out-in-in SNCoii in-in ActLoopNT-in 2.9967 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -171.82, 179.6 APE9-dihe-na 132.39, -163.28 APE8-dihe-in -113.8, 132.71 APE8-rot-in 303.74 APE67-dihe-in -61.94, -22.49 -35.42, -58.51 APE12-dist-in 8.7599 APE11-dist-in 11.7256 APE10-dist-in 6.5394 APE9-dist-in 3.7699 None TPO412,TPO564 TPO412,TPO564 XRAY 2.1 0.25 0.301 B 345.0 326.0 14 28 25 3 [[254, 522]] 1.0 3a8w Homo sapiens AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1.0 260.0 260.0 395 396 397 399 401 283 302 306 375 377 376 378.0 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKG1 KGP1_HUMAN 7T4TA Q13976 204 671 671.0 PCG:60701,ATP:60702 Allosteric,ATPlike Inactive DFGin 5.8055 14.9328 ABAminus -123.17, -29.2 -107.96, 118.17 -112.33, 30.1 285.53, 74.3 -67.24, -29.77 in-in in 9.5568 Saltbr-in 3.3803 HRD-in -86.67, -51.63 61.2, 10.68 in-in-in SNCiii in-in ActLoopNT-in 2.8595 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -166.89, 164.61 APE9-dihe-na 124.7, -170.63 APE8-dihe-in -100.54, 134.31 APE8-rot-in 302.38 APE67-dihe-in -67.0, -27.98 -44.1, -43.89 APE12-dist-in 7.9413 APE11-dist-in 10.7126 APE10-dist-in 5.3076 APE9-dist-in 3.712 None TPO517 TPO517 XRAY 2.08 0.19 0.221 A 469.0 453.0 0 27 27 0 [[360, 619]] 1.0 7t4t Homo sapiens AGC_PRKG1_HUMAN AGC 6.4e-84 287.2 1.0 260.0 260.0 501 502 503 505 507 390 409 413 481 483 482 484.0 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7T4TB Q13976 204 671 671.0 PCG:60701,ATP:60702 Allosteric,ATPlike Inactive DFGin 5.8004 14.8112 ABAminus -121.38, -38.76 -100.76, 117.73 -112.4, 30.34 285.48, 73.71 -68.75, -29.12 in-in in 9.4009 Saltbr-in 3.3105 HRD-in -86.82, -51.68 61.52, 10.16 in-in-in SNCiii in-in ActLoopNT-in 2.8534 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.5, 164.27 APE9-dihe-na 124.32, -169.95 APE8-dihe-in -101.18, 134.26 APE8-rot-in 302.8 APE67-dihe-in -67.54, -26.94 -44.3, -44.01 APE12-dist-in 7.9575 APE11-dist-in 10.7572 APE10-dist-in 5.3357 APE9-dist-in 3.7168 None TPO517 TPO517 XRAY 2.08 0.19 0.221 B 469.0 453.0 0 27 27 0 [[360, 619]] 1.0 7t4t Homo sapiens AGC_PRKG1_HUMAN AGC 6.4e-84 287.2 1.0 260.0 260.0 501 502 503 505 507 390 409 413 481 483 482 484.0 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
CAMK AURKA AURKA_HUMAN 5DNRA O14965 126 390 403.0 ATP:403 ATPlike Inactive DFGin 5.6553 15.0245 BLAminus -132.27, -179.72 60.78, 76.64 -90.12, 18.66 275.93, 74.44 -56.64, -35.89 in-in in 9.1663 Saltbr-in 2.7468 HRD-in -79.07, -53.73 71.53, 2.24 in-in-out SNCiio in-out ActLoopNT-in 2.9452 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -125.56, 5.88 APE9-dihe-na -79.83, -178.97 APE8-dihe-in -49.83, 123.63 APE8-rot-in 300.84 APE67-dihe-in -48.83, -30.32 -94.71, -13.22 APE12-dist-in 9.3475 APE11-dist-in 13.1152 APE10-dist-out 15.9471 APE9-dist-out 11.2037 None TPO288 TPO288 XRAY 1.95 0.206 0.226 A 272.0 265.0 0 26 26 0 [[133, 383]] 1.0 5dnr Homo sapiens CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DT3A O14965 127 390 403.0 ATP:403 ATPlike Inactive DFGin 5.7307 15.0475 BLAminus -138.47, 178.42 59.62, 78.35 -90.84, 24.83 281.41, 74.26 -61.06, -31.68 in-in in 9.4512 Saltbr-in 2.9168 HRD-in -69.42, -55.99 70.31, -3.53 in-in-out SNCiio in-out ActLoopNT-in 2.8923 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -112.53, -5.85 APE9-dihe-na -110.59, -164.26 APE8-dihe-in -61.03, 149.68 APE8-rot-out 193.86 APE67-dihe-in -45.37, -39.19 -93.82, -1.33 APE12-dist-in 12.1815 APE11-dist-in 10.015 APE10-dist-out 11.6945 APE9-dist-out 10.4874 None TPO287 TPO287 XRAY 2.33 0.21 0.243 A 273.0 264.0 0 26 26 0 [[133, 383]] 1.0 5dt3 Homo sapiens CAMK_AURKA_HUMAN CAMK 6.5e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DRDA O14965 127 390 403.0 ATP:402 ATPlike Inactive DFGin 6.1794 15.4902 BLAminus -124.75, -173.07 54.37, 73.03 -91.89, 14.82 276.39, 76.92 -60.47, -27.86 in-in in 9.0942 Saltbr-in 2.7117 HRD-in -86.49, -50.72 75.89, 5.8 in-in-out SNCiio in-out ActLoopNT-in 3.0093 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -110.08 APE9-dihe-na -77.61, -136.85 APE8-dihe-in -63.84, 145.87 APE8-rot-out 199.39 APE67-dihe-in -52.56, -31.45 -96.52, -6.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.8473 APE9-dist-out 10.6226 T287A None None XRAY 2.13 0.209 0.262 A 273.0 259.0 5 26 21 5 [[133, 383]] 1.0 5drd Homo sapiens CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 1OL6A O14965 128 388 403.0 ATP:1388 ATPlike Inactive DFGin 5.8513 15.6403 BLAminus -135.92, 178.5 52.45, 77.03 -92.23, 24.52 292.21, 75.73 -61.17, -14.48 in-out in 9.9117 Saltbr-out 4.6692 HRD-in -62.99, -55.9 71.29, 3.18 out-in-none SNCoin in-none ActLoopNT-in 3.0994 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.06 APE8-rot-in 336.17 APE67-dihe-in -65.51, -21.75 -47.85, -55.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D274N None None XRAY 3.0 0.277 0.301 A 282.0 246.0 15 26 15 11 [[133, 383]] 1.0 1ol6 Homo sapiens CAMK_AURKA_HUMAN CAMK 4.4e-79 271.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DN3A O14965 125 389 403.0 5DN:402,ATP:404 Allosteric,ATPlike Inactive DFGin 5.6992 15.0424 BLAminus -130.89, -174.42 55.28, 74.81 -88.98, 14.12 275.51, 75.93 -51.92, -35.15 in-in in 9.1659 Saltbr-in 2.7201 HRD-in -77.57, -53.05 71.13, 1.06 in-in-out SNCiio in-out ActLoopNT-in 2.9564 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -118.61, -13.13 APE9-dihe-na -74.86, -176.69 APE8-dihe-in -54.45, 125.21 APE8-rot-in 310.73 APE67-dihe-in -44.24, -34.14 -96.33, -16.24 APE12-dist-in 9.4351 APE11-dist-in 13.2348 APE10-dist-out 15.6674 APE9-dist-out 11.2317 None TPO288 TPO288 XRAY 2.05 0.192 0.203 A 272.0 265.0 0 26 26 0 [[133, 383]] 1.0 5dn3 Homo sapiens CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1EA O14965 127 388 403.0 T0X:401,ATP:403 Allosteric,ATPlike Inactive DFGin 5.7981 14.8074 BLAminus -150.0, 179.01 57.43, 76.53 -96.95, 20.99 278.49, 67.97 -56.09, -34.21 in-in in 9.1906 Saltbr-in 2.8469 HRD-in -74.81, -56.51 74.42, -5.07 in-in-out SNCiio in-out ActLoopNT-in 2.6152 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -165.45, 99.75 APE9-dihe-na -118.34, -95.63 APE8-dihe-in -111.54, 127.78 APE8-rot-in 354.95 APE67-dihe-in -38.77, -37.51 -96.45, -21.24 APE12-dist-in 9.259 APE11-dist-in 13.5443 APE10-dist-out 15.2592 APE9-dist-out 10.8956 None TPO288 TPO288 XRAY 2.798 0.176 0.239 A 272.0 262.0 0 26 26 0 [[133, 383]] 1.0 8c1e Homo sapiens CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DT4A O14965 127 390 403.0 5DN:402,ATP:403 Allosteric,ATPlike Inactive DFGin 6.0226 15.016 BLAminus -131.6, -179.1 56.58, 87.02 -103.91, 25.71 282.11, 78.42 -59.32, -42.3 in-in in 9.5441 Saltbr-in 3.0038 HRD-in -66.18, -52.21 66.74, -14.36 in-in-out SNCiio in-out ActLoopNT-in 2.9439 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -57.69 APE9-dihe-na -89.02, -152.47 APE8-dihe-in -67.56, 141.58 APE8-rot-out 191.42 APE67-dihe-in -59.88, -41.29 -85.27, 2.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.1589 APE9-dist-out 9.9725 None None None XRAY 2.86 0.193 0.256 A 273.0 259.0 5 26 21 5 [[133, 383]] 1.0 5dt4 Homo sapiens CAMK_AURKA_HUMAN CAMK 6.5e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DOSA O14965 127 390 403.0 5DN:402,ATP:403 Allosteric,ATPlike Inactive DFGin 5.9 15.0444 BLAminus -141.11, -178.41 56.44, 85.64 -101.51, 29.55 282.61, 75.97 -61.45, -42.65 in-in in 9.4934 Saltbr-in 2.8607 HRD-in -75.29, -42.25 59.65, -8.83 in-in-out SNCiio in-out ActLoopNT-in 3.0424 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -79.83 APE9-dihe-na -91.08, -144.18 APE8-dihe-in -65.26, 123.97 APE8-rot-out 190.75 APE67-dihe-in -25.49, -64.25 -63.86, -31.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.0331 APE9-dist-out 9.7933 T287A None None XRAY 2.98 0.201 0.273 A 273.0 259.0 5 26 21 5 [[133, 383]] 1.0 5dos Homo sapiens CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DR2A O14965 128 390 403.0 5E1:60401,ATP:60403 Allosteric,ATPlike Inactive DFGin 5.7419 15.1483 BLAminus -112.74, -178.24 59.1, 85.93 -103.74, 31.08 282.48, 80.94 -64.76, -39.96 in-in in 9.2247 Saltbr-in 2.8451 HRD-in -83.01, -54.44 78.2, -2.4 in-in-out SNCiio in-out ActLoopNT-in 2.8713 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -117.43, 59.62 APE9-dihe-na -131.57, -163.05 APE8-dihe-in -74.95, 143.42 APE8-rot-out 161.96 APE67-dihe-in -60.88, -32.64 -91.05, 11.96 APE12-dist-in 12.5259 APE11-dist-in 9.1209 APE10-dist-out 12.6318 APE9-dist-out 10.0391 T287A None None XRAY 2.46 0.225 0.285 A 273.0 263.0 0 26 26 0 [[133, 383]] 1.0 5dr2 Homo sapiens CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OBJA O14965 127 390 403.0 ATP:404,9QK:405 ATPlike,Allosteric Inactive DFGin 6.016 15.9671 None -127.31, -156.34 57.9, -96.92 69.6, 25.6 277.68, 99.91 -74.82, -34.09 out-out out 10.8688 Saltbr-out 3.9746 HRD-in -84.35, -43.15 67.43, 1.86 out-in-out SNCoio in-out ActLoopNT-in 2.747 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -85.06 APE9-dihe-na -106.73, -153.17 APE8-dihe-in -86.88, 144.13 APE8-rot-in 279.73 APE67-dihe-in -52.07, -35.29 -66.02, -11.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.3791 APE9-dist-out 10.1992 None None None XRAY 2.901 0.215 0.245 A 272.0 260.0 4 26 22 4 [[133, 383]] 1.0 5obj Homo sapiens CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1.0 256.0 256.0 273 274 275 277 279 162 181 185 253 255 254 256.0 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK CAMK1 KCC1A_HUMAN 4FG7A Q14012 9 277 370.0 ATP:301 ATPlike None DFGin 6.7328 14.5583 BLAminus -139.66, 179.97 56.25, 83.23 -95.06, 23.76 286.93, 75.78 -57.64, -10.34 in-in in 9.7564 Saltbr-in 2.9877 HRD-in -66.62, -51.56 76.61, -3.11 in-in-none SNCiin in-none ActLoopNT-in 2.9676 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 148.43 APE8-dihe-in -71.0, 118.39 APE8-rot-in 317.82 APE67-dihe-inflip 114.74, -42.57 -57.89, 141.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.1487 None None None XRAY 2.7 0.221 0.246 A 293.0 250.0 19 27 19 8 [[20, 276]] 1.0 4fg7 Homo sapiens CAMK_CAMK1_HUMAN CAMK 6.7e-97 329.7 1.0 256.0 256.0 161 162 163 165 167 49 66 70 138 140 139 141.0 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1 KCC1A_HUMAN 4FG9A Q14012 10 314 370.0 ATP:401 ATPlike Inactive DFGinter 6.3717 9.9232 None -94.72, -48.11 -72.17, 151.42 -111.14, 999.0 291.22, 108.3 999.0, 999.0 out-out out 13.2506 Saltbr-out 11.2127 HRD-in -52.69, -68.08 75.14, -19.91 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 133.2, -24.01 999.0, 22.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.211 0.249 A 320.0 278.0 27 27 9 18 [[20, 276]] 1.0 4fg9 Homo sapiens CAMK_CAMK1_HUMAN CAMK 9.2e-97 329.5 1.0 256.0 256.0 161 162 163 165 167 49 66 70 138 140 139 141.0 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1 KCC1A_HUMAN 4FG9B Q14012 14 314 370.0 ATP:401 ATPlike Inactive DFGinter 6.2867 9.3242 None -97.62, -42.8 -76.25, 145.4 -105.57, 999.0 303.86, 102.8 999.0, 999.0 out-none out 16.8995 Saltbr-none 999.0 HRD-in -42.26, -58.83 67.77, -17.08 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na -80.77, -34.84 APE9-dihe-na -79.39, -52.09 APE8-dihe-in -108.11, 99.06 APE8-rot-none 999.0 APE67-dihe-inflip 97.92, -38.15 -85.42, 136.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.5299 None None None XRAY 2.4 0.211 0.249 B 320.0 279.0 22 27 17 10 [[20, 276]] 1.0 4fg9 Homo sapiens CAMK_CAMK1_HUMAN CAMK 9.2e-97 329.5 1.0 256.0 256.0 161 162 163 165 167 49 66 70 138 140 139 141.0 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1 KCC1A_HUMAN 4FG8A Q14012 10 299 370.0 ATP:401 ATPlike Inactive None 999.0 999.0 None -88.48, -49.15 -70.71, 166.62 -106.58, 999.0 999.0, 999.0 999.0, 999.0 out-none out 14.285 Saltbr-none 999.0 HRD-in -68.76, -57.94 73.69, -12.61 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -41.56 APE8-rot-none 999.0 APE67-dihe-out 113.32, -70.06 -37.24, 130.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.198 0.248 A 315.0 263.0 27 27 10 17 [[20, 276]] 1.0 4fg8 Homo sapiens CAMK_CAMK1_HUMAN CAMK 8.7e-97 329.4 1.0 256.0 256.0 161 162 163 165 167 49 66 70 138 140 139 141.0 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1 KCC1A_HUMAN 4FG8B Q14012 14 299 370.0 ATP:401 ATPlike Inactive None 999.0 999.0 None -101.4, -28.72 -75.18, 152.13 -127.71, -74.73 999.0, 999.0 -143.25, 999.0 out-none out 14.4967 Saltbr-none 999.0 HRD-in -60.93, -60.01 82.66, -21.6 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaino APEdist_nnno APE10-dihe-na -81.34, -37.41 APE9-dihe-na -69.8, -52.82 APE8-dihe-in -110.8, 85.13 APE8-rot-none 999.0 APE67-dihe-out 122.52, -61.56 -92.65, 135.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.9518 None None None XRAY 2.2 0.198 0.248 B 315.0 268.0 18 27 20 7 [[20, 276]] 1.0 4fg8 Homo sapiens CAMK_CAMK1_HUMAN CAMK 8.7e-97 329.4 1.0 256.0 256.0 161 162 163 165 167 49 66 70 138 140 139 141.0 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK2A KCC2A_HUMAN 7UIRA Q9UQM7 7 274 478.0 ATP:302 ATPlike Active DFGin 6.0448 15.1065 BLAminus -137.0, 179.68 44.28, 101.28 -106.42, 24.78 295.79, 81.95 -53.14, -27.06 in-in in 9.8503 Saltbr-in 3.4665 HRD-in -74.22, -43.69 67.52, 3.92 in-in-in SNCiii in-in ActLoopNT-in 2.9094 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.48, 156.41 APE9-dihe-na 131.95, -156.1 APE8-dihe-in -122.09, 129.91 APE8-rot-in 298.28 APE67-dihe-in -55.12, -36.11 -51.43, -40.3 APE12-dist-in 10.3326 APE11-dist-in 11.7934 APE10-dist-in 6.0556 APE9-dist-in 3.4247 D135N,Q223K None None XRAY 3.1 0.234 0.274 A 268.0 268.0 0 28 28 0 [[13, 271]] 1.0 7uir Homo sapiens CAMK_CAMK2A_HUMAN CAMK 9.3e-96 326.0 1.0 256.0 256.0 155 156 157 159 161 42 60 64 132 134 133 135.0 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 7UIRB Q9UQM7 7 273 478.0 ATP:301 ATPlike Active DFGin 6.0928 14.4626 BLAminus -136.84, -179.4 43.86, 99.82 -105.8, 24.57 296.99, 81.24 -56.04, -26.17 in-in in 9.4034 Saltbr-in 3.0273 HRD-in -74.93, -42.65 67.84, 3.24 in-in-in SNCiii in-in ActLoopNT-in 2.9153 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.86, 157.92 APE9-dihe-na 132.59, -155.55 APE8-dihe-in -122.09, 129.05 APE8-rot-in 298.73 APE67-dihe-in -54.7, -35.97 -51.63, -40.47 APE12-dist-in 10.3035 APE11-dist-in 11.733 APE10-dist-in 5.9892 APE9-dist-in 3.5041 D135N,Q223K None None XRAY 3.1 0.234 0.274 B 268.0 261.0 6 28 28 0 [[13, 271]] 1.0 7uir Homo sapiens CAMK_CAMK2A_HUMAN CAMK 9.3e-96 326.0 1.0 256.0 256.0 155 156 157 159 161 42 60 64 132 134 133 135.0 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 7UJPB Q9UQM7 7 273 478.0 ATP:301 ATPlike Active DFGin 6.9424 14.3134 BLAminus -133.64, 174.92 62.39, 75.15 -97.38, 27.07 283.14, 81.65 -64.42, -25.12 in-in in 8.5581 Saltbr-in 2.7832 HRD-in -76.01, -51.46 77.74, -9.31 in-in-in SNCiii in-in ActLoopNT-in 2.8708 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.94, 139.06 APE9-dihe-na 146.74, -166.31 APE8-dihe-in -115.05, 124.1 APE8-rot-in 308.42 APE67-dihe-in -69.31, -14.12 -35.51, -54.36 APE12-dist-in 10.2497 APE11-dist-in 11.5916 APE10-dist-in 5.8425 APE9-dist-in 3.5719 D135N,Q223K None None XRAY 2.56 0.234 0.281 B 268.0 267.0 0 28 28 0 [[13, 271]] 1.0 7ujp Homo sapiens CAMK_CAMK2A_HUMAN CAMK 9.3e-96 326.0 1.0 256.0 256.0 155 156 157 159 161 42 60 64 132 134 133 135.0 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 7UJTA Q9UQM7 7 274 478.0 ATP:301 ATPlike Inactive DFGin 5.7931 15.8712 BLAminus -136.06, 173.98 63.2, 83.03 -96.5, 26.66 288.93, 81.42 -61.86, -26.9 out-out out 10.3543 Saltbr-out 4.9623 HRD-in -68.86, -51.05 77.4, -6.28 out-in-in SNCoii in-in ActLoopNT-in 2.8651 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.17, 142.76 APE9-dihe-na 138.67, -159.02 APE8-dihe-in -111.71, 119.97 APE8-rot-in 304.14 APE67-dihe-in -65.52, -19.91 -39.43, -49.22 APE12-dist-in 10.4065 APE11-dist-in 11.7914 APE10-dist-in 5.962 APE9-dist-in 3.8351 D135N,Q223K None None XRAY 2.1 0.205 0.246 A 268.0 268.0 0 28 28 0 [[13, 271]] 1.0 7ujt Homo sapiens CAMK_CAMK2A_HUMAN CAMK 9.3e-96 326.0 1.0 256.0 256.0 155 156 157 159 161 42 60 64 132 134 133 135.0 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK PHKG1 PHKG1_HUMAN 8Z5RC Q16816 12 383 387.0 ATP:401 ATPlike Inactive DFGin 6.2158 15.7899 BLAminus -134.62, -175.38 59.67, 63.56 -84.41, -0.54 270.17, 147.24 -63.63, -41.24 out-none out 10.4151 Saltbr-none 999.0 HRD-in -97.74, -41.95 55.77, 14.53 none-out-in SNCnoi out-in ActLoopNT-out 3.722 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.82, 162.86 APE9-dihe-na 112.58, 179.42 APE8-dihe-in -65.24, 137.27 APE8-rot-in 278.19 APE67-dihe-in -93.32, 13.97 -60.86, -18.95 APE12-dist-in 9.6172 APE11-dist-in 12.1625 APE10-dist-in 7.279 APE9-dist-in 5.4521 None None None EM 3.52 999.0 999.0 C 387.0 372.0 0 27 27 0 [[20, 288]] 1.0 8z5r Homo sapiens CAMK_PHKG1_HUMAN CAMK 1.4e-85 292.7 1.0 256.0 256.0 167 168 169 171 173 49 74 78 147 149 148 150.0 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK PHKG1 PHKG1_HUMAN 8Z5TC Q16816 12 383 387.0 ATP:401 ATPlike Inactive DFGin 5.9663 13.9887 BLAminus -135.48, -169.66 58.09, 63.88 -81.9, 2.43 303.6, 100.06 -62.94, -40.27 out-none out 10.6871 Saltbr-none 999.0 HRD-in -92.65, -46.31 62.21, 13.41 none-out-in SNCnoi out-in ActLoopNT-out 3.7863 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.91, 163.41 APE9-dihe-na 112.45, -178.89 APE8-dihe-in -64.37, 134.79 APE8-rot-in 304.3 APE67-dihe-in -88.43, 6.38 -60.59, -20.91 APE12-dist-in 9.3478 APE11-dist-in 12.0888 APE10-dist-in 7.2113 APE9-dist-in 5.3437 None None None EM 3.74 999.0 999.0 C 387.0 372.0 0 27 27 0 [[20, 288]] 1.0 8z5t Homo sapiens CAMK_PHKG1_HUMAN CAMK 1.4e-85 292.7 1.0 256.0 256.0 167 168 169 171 173 49 74 78 147 149 148 150.0 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK PHKG1 PHKG1_HUMAN 8Z5TG Q16816 12 383 387.0 ATP:401 ATPlike Inactive DFGin 6.2112 16.3499 BLAminus -138.41, -165.95 59.18, 62.46 -88.91, 3.24 271.18, 147.97 -59.75, -36.25 out-none out 10.6402 Saltbr-none 999.0 HRD-in -91.86, -44.41 50.14, 19.86 none-out-out SNCnoo out-out ActLoopNT-out 3.7877 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -170.81, -171.47 APE9-dihe-na 86.12, 176.52 APE8-dihe-in -63.45, 134.1 APE8-rot-in 318.38 APE67-dihe-in -94.57, 4.67 -60.84, -20.41 APE12-dist-in 10.0986 APE11-dist-out 14.0191 APE10-dist-out 9.0465 APE9-dist-in 5.8328 None None None EM 3.74 999.0 999.0 G 387.0 372.0 0 27 27 0 [[20, 288]] 1.0 8z5t Homo sapiens CAMK_PHKG1_HUMAN CAMK 1.4e-85 292.7 1.0 256.0 256.0 167 168 169 171 173 49 74 78 147 149 148 150.0 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK PHKG1 PHKG1_HUMAN 8Z5TK Q16816 12 383 387.0 ATP:401 ATPlike Inactive DFGin 6.8189 16.4302 BLAminus -134.15, -169.32 57.8, 62.87 -86.64, 0.65 265.34, 130.05 -62.73, -39.71 out-none out 10.3313 Saltbr-none 999.0 HRD-in -97.03, -55.84 67.06, 16.56 none-out-in SNCnoi out-in ActLoopNT-out 3.8051 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.95, 163.43 APE9-dihe-na 106.51, -175.76 APE8-dihe-in -64.59, 130.37 APE8-rot-in 311.03 APE67-dihe-in -88.59, 5.57 -61.92, -16.15 APE12-dist-in 9.5541 APE11-dist-in 12.2731 APE10-dist-in 7.3662 APE9-dist-in 5.2682 None None None EM 3.74 999.0 999.0 K 387.0 372.0 0 27 27 0 [[20, 288]] 1.0 8z5t Homo sapiens CAMK_PHKG1_HUMAN CAMK 1.4e-85 292.7 1.0 256.0 256.0 167 168 169 171 173 49 74 78 147 149 148 150.0 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK PHKG1 PHKG1_HUMAN 8Z5TO Q16816 12 383 387.0 ATP:401 ATPlike Inactive DFGin 6.3258 15.7903 BLAminus -126.17, -170.44 58.71, 63.18 -85.3, 0.59 276.38, 60.06 -63.17, -41.01 out-none out 10.5393 Saltbr-none 999.0 HRD-in -82.25, -48.84 62.3, 10.36 none-out-in SNCnoi out-in ActLoopNT-out 3.6965 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.09, 163.04 APE9-dihe-na 110.51, -176.12 APE8-dihe-in -65.19, 138.82 APE8-rot-in 315.28 APE67-dihe-in -94.37, 8.66 -62.65, -15.41 APE12-dist-in 9.5578 APE11-dist-in 12.0862 APE10-dist-in 7.1947 APE9-dist-in 5.5204 None None None EM 3.74 999.0 999.0 O 387.0 372.0 0 27 27 0 [[20, 288]] 1.0 8z5t Homo sapiens CAMK_PHKG1_HUMAN CAMK 1.4e-85 292.7 1.0 256.0 256.0 167 168 169 171 173 49 74 78 147 149 148 150.0 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK STK17B ST17B_HUMAN 7Q7DA O94768 25 297 372.0 ATP:60401 ATPlike Inactive DFGin 5.9795 13.9807 BLAminus -131.01, 179.34 62.41, 83.11 -104.07, 20.6 289.75, 84.41 -62.74, -20.86 in-in in 9.3477 Saltbr-in 3.5375 HRD-in -65.32, -50.49 69.46, 8.5 in-in-out SNCiio in-out ActLoopNT-in 3.0576 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -156.23, 8.1 APE9-dihe-na -82.21, -176.47 APE8-dihe-in -53.98, 115.12 APE8-rot-in 320.45 APE67-dihe-in -72.35, -13.63 -52.11, -32.33 APE12-dist-in 7.7479 APE11-dist-in 12.291 APE10-dist-out 11.2185 APE9-dist-out 7.5968 None None None XRAY 2.6 0.196 0.235 A 327.0 273.0 0 27 27 0 [[32, 293]] 1.0 7q7d Homo sapiens CAMK_STK17B_HUMAN CAMK 1.4e-81 279.8 4.0 256.0 253.0 178 179 180 182 184 62 80 84 155 157 156 158.0 217 205 200 199 198 197 196 195 194 111 Serine/threonine-protein kinase 17B
CAMK STK17B ST17B_HUMAN 7Q7EA O94768 25 297 372.0 ATP:60401 ATPlike Inactive DFGin 5.8059 13.997 BLAminus -136.48, 179.08 63.28, 89.42 -111.5, 27.32 288.43, 87.78 -70.0, -15.51 in-in in 9.3126 Saltbr-in 3.1174 HRD-in -75.17, -47.59 66.91, 14.25 in-in-out SNCiio in-out ActLoopNT-in 3.4002 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -119.2, -9.71 APE9-dihe-na -66.55, 174.56 APE8-dihe-in -49.86, 121.22 APE8-rot-in 313.96 APE67-dihe-in -70.36, -7.82 -52.35, -34.48 APE12-dist-in 7.3784 APE11-dist-in 12.1105 APE10-dist-out 10.7897 APE9-dist-out 7.473 None None None XRAY 2.85 0.191 0.239 A 327.0 273.0 0 27 27 0 [[32, 293]] 1.0 7q7e Homo sapiens CAMK_STK17B_HUMAN CAMK 1.4e-81 279.8 4.0 256.0 253.0 178 179 180 182 184 62 80 84 155 157 156 158.0 217 205 200 199 198 197 196 195 194 111 Serine/threonine-protein kinase 17B
CK1 TTBK1 TTBK1_HUMAN 4BTJB Q5TCY1 21 313 1321.0 ATP:61338 ATPlike Active DFGin 5.3516 12.7176 BLAminus -122.53, 168.88 60.17, 88.3 -98.51, 13.52 307.1, 115.33 -64.8, -32.06 in-in in 7.1484 Saltbr-in 2.816 HRD-in -78.94, -51.75 72.7, -0.47 in-in-in SNCiii in-in ActLoopNT-in 2.7477 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.82, -14.94 APE9-dihe-na -62.51, -161.18 APE8-dihe-in -100.71, 125.28 APE8-rot-in 309.68 APE67-dihe-in -55.66, -43.07 -52.23, -50.62 APE12-dist-in 11.0775 APE11-dist-in 10.8163 APE10-dist-in 6.4629 APE9-dist-in 4.3282 None None None XRAY 2.16 0.179 0.197 B 337.0 293.0 0 34 34 0 [[34, 295]] 1.0 4btj Homo sapiens CK1_TTBK1_HUMAN CK1 5.7e-105 356.4 1.0 262.0 262.0 175 176 177 179 181 63 77 81 151 153 152 154.0 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
CMGC CDK2 CDK2_HUMAN 4EOOA P24941 1 297 298.0 ATP:60302 ATPlike Inactive DFGin 6.651 15.121 BLAminus -137.3, -178.29 51.93, 74.48 -88.78, 23.73 283.58, 71.37 -66.89, -17.34 in-in in 8.7539 Saltbr-in 2.7738 HRD-in -82.21, -55.51 72.81, 10.91 in-in-out SNCiio in-out ActLoopNT-in 2.8784 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.74, 151.81 APE9-dihe-na 71.22, 125.56 APE8-dihe-in -63.52, 145.17 APE8-rot-out 106.26 APE67-dihe-in -59.56, -25.92 -46.12, -48.45 APE12-dist-in 12.954 APE11-dist-in 10.3073 APE10-dist-in 7.1329 APE9-dist-in 3.2473 Q131E TPO160 TPO160 XRAY 2.1 0.216 0.253 A 299.0 293.0 4 28 28 0 [[4, 286]] 1.0 4eoo Homo sapiens CMGC_CDK2_HUMAN CMGC 3.7e-90 308.6 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOOC P24941 1 296 298.0 ATP:60301 ATPlike Inactive DFGin 6.4414 15.2546 BLAminus -132.94, -176.35 50.17, 74.17 -84.23, 27.4 283.88, 71.77 -62.65, -24.02 in-in in 8.772 Saltbr-in 2.7246 HRD-in -84.21, -52.66 66.89, 14.22 in-in-out SNCiio in-out ActLoopNT-in 2.986 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -124.67, 158.22 APE9-dihe-na 65.39, 129.96 APE8-dihe-in -70.44, 149.36 APE8-rot-out 84.06 APE67-dihe-in -53.86, -24.11 -49.71, -53.55 APE12-dist-in 12.8075 APE11-dist-in 10.0033 APE10-dist-in 6.7498 APE9-dist-in 3.2864 Q131E TPO160 TPO160 XRAY 2.1 0.216 0.253 C 299.0 296.0 0 28 28 0 [[4, 286]] 1.0 4eoo Homo sapiens CMGC_CDK2_HUMAN CMGC 3.7e-90 308.6 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOMA P24941 1 297 298.0 ATP:60301 ATPlike Inactive DFGin 6.7655 15.173 BLAminus -135.89, -179.95 56.75, 76.33 -93.68, 18.3 281.75, 72.51 -65.02, -17.06 in-in in 8.6563 Saltbr-in 2.9544 HRD-in -79.7, -58.84 74.79, 7.53 in-in-out SNCiio in-out ActLoopNT-in 2.8551 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na 71.17, 129.47 APE9-dihe-na 73.49, 129.68 APE8-dihe-in -66.58, 140.55 APE8-rot-out 117.21 APE67-dihe-in -54.12, -27.93 -44.4, -51.19 APE12-dist-in 13.2687 APE11-dist-in 9.2266 APE10-dist-in 7.1533 APE9-dist-in 3.2593 H84S,Q85M,Q131E TPO160 TPO160 XRAY 2.1 0.21 0.243 A 301.0 295.0 2 28 28 0 [[4, 286]] 1.0 4eom Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOMC P24941 1 296 298.0 ATP:60301 ATPlike Inactive DFGin 6.6125 15.1214 BLAminus -134.3, 179.46 56.9, 73.57 -89.28, 27.08 288.28, 71.72 -61.57, -29.46 in-in in 8.464 Saltbr-in 2.7643 HRD-in -79.86, -55.51 70.21, 14.99 in-in-out SNCiio in-out ActLoopNT-in 2.9883 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.3, 158.32 APE9-dihe-na 61.45, 125.91 APE8-dihe-in -61.76, 140.91 APE8-rot-out 72.97 APE67-dihe-in -49.53, -25.94 -36.27, -61.03 APE12-dist-in 12.8462 APE11-dist-in 9.6798 APE10-dist-in 6.9437 APE9-dist-in 3.3597 H84S,Q85M,Q131E TPO160 TPO160 XRAY 2.1 0.21 0.243 C 301.0 272.0 24 28 28 0 [[4, 286]] 1.0 4eom Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1FINA P24941 1 298 298.0 ATP:299 ATPlike Inactive DFGin 6.2688 15.3969 BLAminus -145.66, 175.42 60.17, 70.41 -88.62, 22.31 287.3, 65.31 -62.81, -23.63 in-in in 8.878 Saltbr-in 3.0657 HRD-in -75.81, -52.6 66.76, 11.52 in-in-out SNCiio in-out ActLoopNT-in 2.8478 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -159.69, 149.42 APE9-dihe-na -56.35, 161.85 APE8-dihe-in -65.27, 149.59 APE8-rot-out 191.08 APE67-dihe-in -48.48, -30.03 -41.87, -56.23 APE12-dist-in 10.4278 APE11-dist-out 5.9243 APE10-dist-out 8.9912 APE9-dist-in 4.1466 None None None XRAY 2.3 0.208 999.0 A 298.0 298.0 0 28 28 0 [[4, 286]] 1.0 1fin Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1FINC P24941 1 298 298.0 ATP:299 ATPlike Inactive DFGin 6.3292 16.1138 BLAminus -126.26, 177.09 60.06, 80.37 -100.41, 24.94 280.63, 71.46 -64.88, -37.23 in-in in 9.2342 Saltbr-in 3.0157 HRD-in -71.64, -45.48 67.73, -0.73 in-in-out SNCiio in-out ActLoopNT-in 2.6571 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -100.08, 164.84 APE9-dihe-na -64.11, 161.66 APE8-dihe-in -58.82, 141.21 APE8-rot-in 296.75 APE67-dihe-in -52.5, -36.66 -49.82, -46.41 APE12-dist-in 10.426 APE11-dist-out 6.2386 APE10-dist-out 9.723 APE9-dist-in 3.9072 None None None XRAY 2.3 0.208 999.0 C 298.0 298.0 0 28 28 0 [[4, 286]] 1.0 1fin Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1FQ1B P24941 1 296 298.0 ATP:381 ATPlike Inactive DFGin 6.7737 15.6217 BLAminus -151.24, -169.54 37.68, 67.63 -81.17, 26.85 274.26, 50.62 -66.75, -18.36 in-out in 9.807 Saltbr-out 3.7302 HRD-in -76.57, -60.94 80.93, -25.61 out-in-out SNCoio in-out ActLoopNT-in 2.6096 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oioo APE10-dihe-na -104.21, 92.46 APE9-dihe-na -93.56, -175.8 APE8-dihe-out -64.18, -46.74 APE8-rot-in 317.22 APE67-dihe-out -56.53, -27.84 69.72, -12.02 APE12-dist-out 16.1127 APE11-dist-in 11.9019 APE10-dist-out 15.5944 APE9-dist-out 10.1307 None TPO160 TPO160 XRAY 3.0 0.235 0.313 B 298.0 296.0 0 28 28 0 [[4, 286]] 1.0 1fq1 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1JSTA P24941 1 298 298.0 ATP:300 ATPlike Active DFGin 6.4269 15.4642 BLAminus -139.88, 179.46 48.93, 78.76 -92.24, 30.29 284.11, 71.63 -70.08, -30.4 in-in in 8.7168 Saltbr-in 2.7569 HRD-in -78.76, -47.67 60.69, 17.81 in-in-in SNCiii in-in ActLoopNT-in 2.9493 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.53, 164.64 APE9-dihe-na 80.72, 135.16 APE8-dihe-in -62.71, 138.95 APE8-rot-in 293.52 APE67-dihe-in -51.22, -30.94 -33.79, -62.16 APE12-dist-in 13.1212 APE11-dist-in 11.9337 APE10-dist-in 7.067 APE9-dist-in 3.2775 None TPO160 TPO160 XRAY 2.6 0.2 999.0 A 298.0 298.0 0 28 28 0 [[4, 286]] 1.0 1jst Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1JSTC P24941 1 298 298.0 ATP:300 ATPlike Active DFGin 6.225 15.1331 BLAminus -133.76, 179.75 53.92, 86.29 -100.05, 15.63 279.16, 71.07 -59.91, -21.96 in-in in 8.679 Saltbr-in 2.9469 HRD-in -76.84, -49.3 61.77, 13.04 in-in-in SNCiii in-in ActLoopNT-in 2.7007 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.31, -163.7 APE9-dihe-na 66.67, 148.27 APE8-dihe-in -72.61, 126.34 APE8-rot-in 301.65 APE67-dihe-in -51.49, -27.24 -26.21, -64.21 APE12-dist-in 13.4121 APE11-dist-in 12.7409 APE10-dist-in 6.9421 APE9-dist-in 3.2045 None TPO160 TPO160 XRAY 2.6 0.2 999.0 C 298.0 298.0 0 28 28 0 [[4, 286]] 1.0 1jst Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2CJMA P24941 1 292 298.0 ATP:1294 ATPlike Active DFGin 6.4115 15.4766 BLAminus -133.49, 174.28 59.08, 80.72 -93.05, 17.33 280.25, 71.88 -51.1, -37.87 in-in in 8.875 Saltbr-in 3.0274 HRD-in -83.77, -55.33 74.52, 15.85 in-in-in SNCiii in-in ActLoopNT-in 2.7962 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.97, -48.89 APE9-dihe-na -98.03, 148.0 APE8-dihe-in -53.4, 136.55 APE8-rot-in 296.67 APE67-dihe-in -56.28, -31.52 -52.78, -45.83 APE12-dist-in 13.3285 APE11-dist-in 10.5533 APE10-dist-in 7.1798 APE9-dist-in 3.4643 None PTR15,TPO160 PTR15,TPO160 XRAY 2.3 0.204 0.265 A 298.0 287.0 5 28 28 0 [[4, 286]] 1.0 2cjm Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2CJMC P24941 1 297 298.0 ATP:1298 ATPlike Active DFGin 6.4464 15.3889 BLAminus -136.23, -173.15 48.46, 78.84 -90.01, 21.15 280.3, 74.36 -53.78, -24.47 in-in in 8.9566 Saltbr-in 2.575 HRD-in -82.67, -49.67 67.53, 9.26 in-in-in SNCiii in-in ActLoopNT-in 2.9786 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.3, -72.35 APE9-dihe-na -81.21, 139.76 APE8-dihe-in -48.67, 128.86 APE8-rot-in 299.02 APE67-dihe-in -54.58, -22.4 -47.31, -51.92 APE12-dist-in 13.0675 APE11-dist-in 10.808 APE10-dist-in 7.0087 APE9-dist-in 3.5797 None PTR15,TPO160 PTR15,TPO160 XRAY 2.3 0.204 0.265 C 298.0 297.0 0 28 28 0 [[4, 286]] 1.0 2cjm Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1GY3A P24941 1 296 298.0 ATP:1297 ATPlike Active DFGin 6.7113 15.7388 BLAminus -148.85, -171.85 44.28, 78.14 -91.55, 12.53 280.84, 73.84 -49.56, -35.56 in-in in 8.826 Saltbr-in 2.8696 HRD-in -78.88, -56.55 74.04, 15.78 in-in-in SNCiii in-in ActLoopNT-in 3.1293 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.01, 152.98 APE9-dihe-na 75.99, 139.26 APE8-dihe-in -71.28, 139.34 APE8-rot-in 297.69 APE67-dihe-in -59.44, -30.42 -47.65, -49.93 APE12-dist-in 13.1561 APE11-dist-in 10.6778 APE10-dist-in 7.643 APE9-dist-in 3.395 None TPO160 TPO160 XRAY 2.7 0.25 0.313 A 299.0 296.0 0 28 28 0 [[4, 286]] 1.0 1gy3 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1GY3C P24941 1 296 298.0 ATP:1298 ATPlike Active DFGin 6.8235 15.3763 BLAminus -159.42, -172.39 46.56, 69.8 -88.25, 18.8 278.1, 68.22 -63.28, -3.45 in-in in 8.6103 Saltbr-in 3.3162 HRD-in -72.89, -69.46 86.12, 7.32 in-in-in SNCiii in-in ActLoopNT-in 2.7939 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.99, 145.31 APE9-dihe-na 77.28, 144.74 APE8-dihe-in -75.96, 137.92 APE8-rot-in 277.1 APE67-dihe-in -64.24, -30.46 -41.97, -49.4 APE12-dist-in 13.1946 APE11-dist-in 10.6355 APE10-dist-in 7.7718 APE9-dist-in 3.2116 None TPO160 TPO160 XRAY 2.7 0.25 0.313 C 299.0 296.0 0 28 28 0 [[4, 286]] 1.0 1gy3 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1QMZA P24941 1 296 298.0 ATP:60381 ATPlike Active DFGin 6.4238 15.17 BLAminus -146.26, -172.65 47.53, 78.45 -93.94, 24.34 280.23, 76.95 -74.2, -4.32 in-in in 8.7401 Saltbr-in 2.6634 HRD-in -79.61, -61.2 70.52, 19.43 in-in-in SNCiii in-in ActLoopNT-in 2.9813 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.31, 152.76 APE9-dihe-na 72.53, 130.75 APE8-dihe-in -60.65, 130.8 APE8-rot-in 293.88 APE67-dihe-in -60.7, -26.37 -33.48, -54.72 APE12-dist-in 13.0196 APE11-dist-in 10.0953 APE10-dist-in 7.17 APE9-dist-in 3.2347 None TPO160 TPO160 XRAY 2.2 0.22 0.28 A 299.0 296.0 0 28 28 0 [[4, 286]] 1.0 1qmz Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1QMZC P24941 1 296 298.0 ATP:60381 ATPlike Active DFGin 6.5123 15.1345 BLAminus -147.61, -169.98 41.15, 80.53 -95.52, 25.6 283.09, 73.82 -79.03, -0.31 in-in in 8.7403 Saltbr-in 2.5397 HRD-in -75.88, -57.22 71.34, 18.39 in-in-in SNCiii in-in ActLoopNT-in 2.9931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.04, 148.92 APE9-dihe-na 73.46, 130.58 APE8-dihe-in -61.75, 132.61 APE8-rot-in 296.97 APE67-dihe-in -70.09, -17.52 -37.4, -48.3 APE12-dist-in 12.9473 APE11-dist-in 10.1029 APE10-dist-in 7.1904 APE9-dist-in 3.2342 None TPO160 TPO160 XRAY 2.2 0.22 0.28 C 299.0 296.0 0 28 28 0 [[4, 286]] 1.0 1qmz Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2CCHA P24941 1 296 298.0 ATP:61297 ATPlike Active DFGin 6.6481 15.4963 BLAminus -138.14, 178.31 65.58, 62.78 -86.23, 16.74 281.6, 70.81 -63.75, -23.41 in-in in 8.7947 Saltbr-in 2.8278 HRD-in -78.21, -56.44 71.04, 15.24 in-in-in SNCiii in-in ActLoopNT-in 2.8968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.4, 152.64 APE9-dihe-na 69.68, 132.94 APE8-dihe-in -57.07, 137.05 APE8-rot-in 294.63 APE67-dihe-in -60.03, -20.02 -46.03, -52.89 APE12-dist-in 13.1982 APE11-dist-in 10.3601 APE10-dist-in 7.2078 APE9-dist-in 3.2861 None TPO160 TPO160 XRAY 1.7 0.15 0.182 A 299.0 296.0 0 28 28 0 [[4, 286]] 1.0 2cch Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2CCHC P24941 1 296 298.0 ATP:61297 ATPlike Active DFGin 6.4766 15.3817 BLAminus -137.71, -178.58 51.07, 78.61 -96.17, 22.01 279.1, 72.77 -65.43, -25.94 in-in in 8.6526 Saltbr-in 2.7189 HRD-in -81.45, -53.09 63.51, 17.55 in-in-in SNCiii in-in ActLoopNT-in 2.8858 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.56, 136.55 APE9-dihe-na 76.27, 128.23 APE8-dihe-in -59.37, 134.24 APE8-rot-in 303.33 APE67-dihe-in -63.22, -26.6 -41.45, -49.27 APE12-dist-in 12.8664 APE11-dist-in 10.056 APE10-dist-in 7.3772 APE9-dist-in 3.2603 None TPO160 TPO160 XRAY 1.7 0.15 0.182 C 299.0 296.0 0 28 28 0 [[4, 286]] 1.0 2cch Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2CCIA P24941 1 296 298.0 ATP:61297 ATPlike Active DFGin 6.4591 15.3718 BLAminus -128.71, -173.86 48.01, 81.43 -98.73, 25.24 282.02, 74.31 -66.86, -20.71 in-in in 8.9016 Saltbr-in 3.076 HRD-in -75.27, -47.91 58.22, 13.15 in-in-in SNCiii in-in ActLoopNT-in 2.892 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.39, 140.99 APE9-dihe-na 76.14, 131.3 APE8-dihe-in -63.2, 133.24 APE8-rot-in 305.53 APE67-dihe-in -53.35, -21.65 -35.23, -63.18 APE12-dist-in 12.9583 APE11-dist-in 10.3232 APE10-dist-in 7.2456 APE9-dist-in 3.2913 None TPO160 TPO160 XRAY 2.7 0.264 0.321 A 299.0 296.0 0 28 28 0 [[4, 286]] 1.0 2cci Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2CCIC P24941 1 296 298.0 ATP:61297 ATPlike Active DFGin 6.2316 15.3818 BLAminus -129.31, 167.15 64.1, 86.76 -100.18, 28.53 276.86, 72.85 -63.26, -37.36 in-in in 8.5509 Saltbr-in 2.6658 HRD-in -73.66, -47.99 63.69, 10.4 in-in-in SNCiii in-in ActLoopNT-in 3.0639 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.2, 138.6 APE9-dihe-na 71.13, 137.9 APE8-dihe-in -63.98, 129.66 APE8-rot-in 301.4 APE67-dihe-in -61.96, -9.78 -29.15, -60.17 APE12-dist-in 12.7527 APE11-dist-in 9.7665 APE10-dist-in 7.4196 APE9-dist-in 3.2337 None TPO160 TPO160 XRAY 2.7 0.264 0.321 C 299.0 296.0 0 28 28 0 [[4, 286]] 1.0 2cci Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOQA P24941 1 297 298.0 ATP:60301 ATPlike Inactive DFGin 6.6029 15.2578 BLAminus -136.2, -179.04 55.17, 77.3 -91.43, 19.33 282.26, 72.55 -64.29, -18.87 in-in in 8.7855 Saltbr-in 2.8451 HRD-in -79.78, -53.17 69.74, 9.41 in-in-out SNCiio in-out ActLoopNT-in 2.9063 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na 62.26, 128.16 APE9-dihe-na 76.05, 127.33 APE8-dihe-in -62.55, 137.94 APE8-rot-out 115.71 APE67-dihe-in -58.94, -23.33 -43.56, -48.15 APE12-dist-in 13.3614 APE11-dist-in 9.1579 APE10-dist-in 7.1767 APE9-dist-in 3.2463 None TPO160 TPO160 XRAY 2.15 0.201 0.234 A 301.0 294.0 3 28 28 0 [[4, 286]] 1.0 4eoq Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOQC P24941 1 296 298.0 ATP:60301 ATPlike Inactive DFGin 6.5834 15.2493 BLAminus -140.92, -177.14 51.0, 72.99 -85.26, 24.65 284.32, 71.69 -63.95, -27.55 in-in in 8.6489 Saltbr-in 2.7133 HRD-in -79.85, -57.3 73.26, 6.95 in-in-out SNCiio in-out ActLoopNT-in 2.9487 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -135.95, 149.43 APE9-dihe-na 70.01, 126.65 APE8-dihe-in -62.68, 144.35 APE8-rot-out 86.91 APE67-dihe-in -60.3, -23.97 -41.77, -51.35 APE12-dist-in 12.9226 APE11-dist-in 9.9884 APE10-dist-in 7.0552 APE9-dist-in 3.1801 None TPO160 TPO160 XRAY 2.15 0.201 0.234 C 301.0 272.0 24 28 28 0 [[4, 286]] 1.0 4eoq Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOJA P24941 1 298 298.0 ATP:60301 ATPlike Inactive DFGin 6.6711 15.3765 BLAminus -134.08, 177.58 53.89, 78.08 -94.34, 17.78 277.91, 75.6 -65.2, -18.6 in-in in 8.6422 Saltbr-in 2.9234 HRD-in -77.88, -54.19 68.96, 13.72 in-in-out SNCiio in-out ActLoopNT-in 2.9516 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -80.75, 158.76 APE9-dihe-na 76.84, 131.84 APE8-dihe-in -62.19, 141.78 APE8-rot-out 119.83 APE67-dihe-in -58.91, -24.4 -48.51, -47.68 APE12-dist-in 13.3089 APE11-dist-in 9.1489 APE10-dist-in 7.3326 APE9-dist-in 3.2138 H84S,Q85M,K89D TPO160 TPO160 XRAY 1.65 0.197 0.215 A 302.0 294.0 4 28 28 0 [[4, 286]] 1.0 4eoj Homo sapiens CMGC_CDK2_HUMAN CMGC 2.1e-89 306.1 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOJC P24941 1 296 298.0 ATP:60301 ATPlike Inactive DFGin 6.6044 15.375 BLAminus -136.46, -177.75 51.71, 75.47 -89.77, 20.18 280.05, 73.98 -59.21, -28.77 in-in in 8.5899 Saltbr-in 2.6303 HRD-in -79.08, -54.75 70.82, 10.21 in-in-out SNCiio in-out ActLoopNT-in 2.9181 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.67, 155.4 APE9-dihe-na 67.15, 126.49 APE8-dihe-in -61.14, 141.64 APE8-rot-out 49.99 APE67-dihe-in -62.84, -21.66 -42.97, -49.5 APE12-dist-in 12.8966 APE11-dist-in 9.8259 APE10-dist-in 6.8336 APE9-dist-in 3.1843 H84S,Q85M,K89D TPO160 TPO160 XRAY 1.65 0.197 0.215 C 302.0 279.0 17 28 28 0 [[4, 286]] 1.0 4eoj Homo sapiens CMGC_CDK2_HUMAN CMGC 2.1e-89 306.1 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1HCKA P24941 1 298 298.0 ATP:400 ATPlike Inactive DFGin 10.5207 18.374 BLBtrans -101.64, 156.72 59.01, 28.24 -65.02, 120.2 217.92, 114.75 87.03, -4.22 out-out out 14.8863 Saltbr-out 16.6024 HRD-in -89.06, -54.55 70.31, -1.71 out-out-out SNCooo out-out ActLoopNT-out 5.7676 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -59.61, 130.9 APE9-dihe-na -79.22, 142.0 APE8-dihe-in -76.12, 133.01 APE8-rot-out 180.79 APE67-dihe-in -48.4, -27.96 -101.36, -7.62 APE12-dist-out 20.0772 APE11-dist-out 17.5988 APE10-dist-out 19.4709 APE9-dist-out 11.0313 None None None XRAY 1.9 0.185 0.272 A 298.0 294.0 4 28 28 0 [[4, 286]] 1.0 1hck Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 8FP5A P24941 2 298 298.0 ATP:302 ATPlike Inactive DFGin 10.3755 18.3199 BLBtrans -107.51, 151.36 65.27, 30.62 -67.28, 128.54 213.84, 133.39 81.57, 1.02 out-out out 15.7956 Saltbr-out 15.8731 HRD-in -85.24, -57.92 82.57, -13.18 out-out-out SNCooo out-out ActLoopNT-out 5.8933 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -82.36, 136.98 APE9-dihe-na -71.53, 131.08 APE8-dihe-in -77.4, 124.67 APE8-rot-in 308.71 APE67-dihe-in -62.7, -24.4 -97.59, -2.61 APE12-dist-out 20.412 APE11-dist-out 17.3616 APE10-dist-out 19.0753 APE9-dist-out 10.9192 None None None XRAY 1.7 0.196 0.23 A 298.0 288.0 9 28 28 0 [[4, 286]] 1.0 8fp5 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1B38A P24941 1 298 298.0 ATP:60381 ATPlike Inactive DFGin 10.1969 18.3025 BLBtrans -95.65, 156.45 60.68, 25.9 -58.03, 132.69 221.26, 95.46 85.91, -14.49 out-out out 15.1536 Saltbr-out 16.0636 HRD-in -76.6, -58.97 89.85, -20.78 out-out-out SNCooo out-out ActLoopNT-out 6.2075 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -77.95, 142.89 APE9-dihe-na -75.18, 129.36 APE8-dihe-in -71.98, 129.31 APE8-rot-out 193.64 APE67-dihe-in -51.99, -31.61 -101.67, -5.99 APE12-dist-out 19.5535 APE11-dist-out 17.4582 APE10-dist-out 18.6728 APE9-dist-out 10.5678 None None None XRAY 2.0 0.18 0.25 A 299.0 290.0 8 28 28 0 [[4, 286]] 1.0 1b38 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1B39A P24941 1 298 298.0 ATP:60381 ATPlike Inactive DFGin 10.5338 18.343 BLBtrans -101.01, 147.7 73.19, 23.92 -63.93, 137.58 224.37, 103.76 85.74, -27.62 out-out out 15.4122 Saltbr-out 16.0286 HRD-in -84.44, -53.29 77.56, -15.37 out-out-out SNCooo out-out ActLoopNT-out 5.8425 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -101.65, 122.32 APE9-dihe-na -57.75, 145.92 APE8-dihe-in -67.9, 142.03 APE8-rot-in 290.02 APE67-dihe-in -56.66, -23.98 -105.17, -10.65 APE12-dist-out 20.4627 APE11-dist-out 17.1833 APE10-dist-out 18.3127 APE9-dist-out 9.9797 None None None XRAY 2.1 0.2 0.27 A 299.0 290.0 8 28 28 0 [[4, 286]] 1.0 1b39 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1.0 301.0 301.0 144 145 146 148 150 33 51 55 124 126 125 127.0 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK7 CDK7_HUMAN 1UA2A P50613 13 311 346.0 ATP:381 ATPlike Inactive DFGin 3.8381 15.0736 None -72.36, 176.54 -63.29, 129.93 -58.5, 61.34 34.11, 88.78 62.95, -115.18 out-out out 13.0144 Saltbr-out 13.6332 HRD-out -71.94, 127.86 -111.75, 17.16 out-out-out SNCooo out-out ActLoopNT-out 10.7811 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -60.17, 155.77 APE9-dihe-na -94.04, -36.01 APE8-dihe-out 80.52, 83.34 APE8-rot-in 310.15 APE67-dihe-in -70.12, 0.07 -111.89, 13.44 APE12-dist-out 21.6082 APE11-dist-out 18.7453 APE10-dist-out 20.4575 APE9-dist-out 13.0189 None TPO170 TPO170 XRAY 3.02 0.217 0.288 A 346.0 287.0 13 28 28 0 [[12, 295]] 1.0 1ua2 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 1UA2B P50613 13 311 346.0 ATP:382 ATPlike Inactive DFGin 4.0749 14.4826 None -83.42, -165.13 -43.25, 135.34 -79.47, 27.14 49.47, 35.58 128.26, -117.59 out-out out 13.2082 Saltbr-out 11.1817 HRD-out -90.35, 54.77 -58.64, -3.2 out-out-out SNCooo out-out ActLoopNT-out 10.7547 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -59.37, 128.97 APE9-dihe-na -70.17, -103.62 APE8-dihe-out 114.41, 132.59 APE8-rot-out 86.06 APE67-dihe-in -64.71, -6.03 -138.86, 19.47 APE12-dist-out 21.3562 APE11-dist-out 17.9388 APE10-dist-out 20.1165 APE9-dist-out 13.1186 None TPO170 TPO170 XRAY 3.02 0.217 0.288 B 346.0 287.0 13 28 28 0 [[12, 295]] 1.0 1ua2 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 1UA2C P50613 13 311 346.0 ATP:383 ATPlike Inactive DFGin 4.3773 15.832 None -69.53, 164.86 -53.4, 113.84 -55.09, 81.41 35.63, 74.81 38.07, -90.08 out-out out 14.2914 Saltbr-out 13.3504 HRD-out -90.81, 75.3 -67.23, 24.34 out-out-out SNCooo out-out ActLoopNT-out 10.7246 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -61.3, 146.02 APE9-dihe-na -103.14, 168.98 APE8-dihe-in -149.98, 115.15 APE8-rot-in 317.59 APE67-dihe-in -70.34, -0.48 -115.08, 9.43 APE12-dist-out 21.9947 APE11-dist-out 19.6363 APE10-dist-out 20.1195 APE9-dist-out 12.6188 None TPO170 TPO170 XRAY 3.02 0.217 0.288 C 346.0 287.0 13 28 28 0 [[12, 295]] 1.0 1ua2 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 1UA2D P50613 13 311 346.0 ATP:384 ATPlike Inactive DFGin 3.9714 15.4823 None -66.13, 178.54 -66.01, 128.6 -62.88, 66.21 38.44, 67.87 63.18, -97.8 out-out out 13.2417 Saltbr-out 13.5751 HRD-out -80.45, 94.07 -71.75, -5.97 out-out-out SNCooo out-out ActLoopNT-out 10.8955 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.63, 129.76 APE9-dihe-na -71.09, 152.84 APE8-dihe-in -147.91, 130.69 APE8-rot-out 68.98 APE67-dihe-in -88.14, 9.58 -128.15, 23.18 APE12-dist-out 22.1448 APE11-dist-out 18.8445 APE10-dist-out 20.0096 APE9-dist-out 12.6573 None TPO170 TPO170 XRAY 3.02 0.217 0.288 D 346.0 287.0 13 28 28 0 [[12, 295]] 1.0 1ua2 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1.0 301.0 301.0 154 155 156 158 160 41 62 66 134 136 135 137.0 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK9 CDK9_HUMAN 3BLQA P50750 7 325 372.0 ATP:332 ATPlike Active DFGin 6.9827 15.2352 BLAminus -137.33, 167.71 61.72, 82.78 -101.54, 27.58 292.13, 71.79 -68.35, -20.47 in-in in 9.5144 Saltbr-in 3.2566 HRD-in -70.77, -57.41 73.91, 6.35 in-in-in SNCiii in-in ActLoopNT-in 2.8505 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.28, 155.2 APE9-dihe-na 75.14, 129.25 APE8-dihe-in -51.14, 147.2 APE8-rot-in 304.68 APE67-dihe-in -62.86, -25.73 -50.2, -49.1 APE12-dist-in 13.0281 APE11-dist-in 11.0296 APE10-dist-in 6.8964 APE9-dist-in 3.1544 None TPO186 TPO186 XRAY 2.9 0.174 0.234 A 331.0 296.0 23 32 25 7 [[19, 315]] 1.0 3blq Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1.0 301.0 301.0 166 167 168 170 172 48 66 70 146 148 147 149.0 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CMGC CSNK2A1 CSK21_HUMAN 5CU6A P68400 3 329 391.0 ATP:401 ATPlike Active DFGin 7.3735 16.3007 BLAminus -117.96, -176.97 52.74, 80.35 -94.88, 19.06 296.35, 83.62 -69.11, -18.98 in-in in 9.2959 Saltbr-in 2.9965 HRD-in -73.54, -48.21 69.17, 10.55 in-in-in SNCiii in-in ActLoopNT-in 2.8943 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.92, 173.11 APE9-dihe-na 58.61, 170.65 APE8-dihe-in -94.81, 150.1 APE8-rot-in 295.17 APE67-dihe-in -71.66, -13.32 -37.08, -56.84 APE12-dist-in 12.6525 APE11-dist-in 10.3342 APE10-dist-in 6.1816 APE9-dist-in 3.1457 R21S,K74A,K75A,K76A None None XRAY 1.36 0.188 0.209 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 5cu6 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZYDA P68400 3 329 391.0 ATP:403,KD6:404 ATPlike,Allosteric Active DFGin 7.3287 16.2144 BLAminus -118.97, -177.69 55.36, 75.35 -91.38, 15.36 296.7, 79.46 -65.95, -20.35 in-in in 9.2711 Saltbr-in 2.8643 HRD-in -76.19, -47.14 68.74, 13.25 in-in-in SNCiii in-in ActLoopNT-in 2.8609 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.11, 172.03 APE9-dihe-na 59.78, 163.78 APE8-dihe-in -88.12, 149.21 APE8-rot-in 297.74 APE67-dihe-in -70.35, -14.8 -37.52, -55.55 APE12-dist-in 12.6652 APE11-dist-in 10.1915 APE10-dist-in 6.197 APE9-dist-in 3.1923 R21S,K74A,K75A,K76A None None XRAY 1.404 0.199 0.214 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 7zyd Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZYRA P68400 3 329 391.0 ATP:401,KF6:406 ATPlike,Allosteric Active DFGin 7.384 16.3356 BLAminus -115.5, -176.17 54.52, 75.81 -90.94, 15.84 295.5, 83.13 -67.01, -21.05 in-in in 9.3003 Saltbr-in 3.0667 HRD-in -73.81, -46.94 67.44, 10.6 in-in-in SNCiii in-in ActLoopNT-in 2.9615 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.26, 163.7 APE9-dihe-na 66.11, 155.14 APE8-dihe-in -79.05, 149.29 APE8-rot-in 297.87 APE67-dihe-in -66.86, -16.16 -37.19, -56.72 APE12-dist-in 12.6488 APE11-dist-in 10.2716 APE10-dist-in 6.0959 APE9-dist-in 3.2817 R21S,K74A,K75A,K76A None None XRAY 1.85 0.17 0.209 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 7zyr Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 8AECA P68400 3 329 391.0 ATP:401,LW3:404 ATPlike,Allosteric Inactive DFGin 7.1758 16.144 BLAminus -118.04, -179.83 50.85, 85.39 -95.14, 14.95 295.73, 81.33 -66.57, -20.11 in-in in 9.2626 Saltbr-in 2.8283 HRD-in -74.16, -49.17 69.92, 11.72 in-in-out SNCiio in-out ActLoopNT-in 2.8412 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.03, 173.8 APE9-dihe-na 56.87, 164.78 APE8-dihe-in -92.58, 150.13 APE8-rot-out 58.14 APE67-dihe-in -68.24, -15.5 -36.53, -56.67 APE12-dist-in 12.6341 APE11-dist-in 10.2886 APE10-dist-in 6.1789 APE9-dist-in 3.1133 R21S,K74A,K75A,K76A None None XRAY 1.09 0.196 0.209 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 8aec Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OSPA P68400 3 329 391.0 ATP:401,A9W:406 ATPlike,Allosteric Active DFGin 7.4481 16.2595 BLAminus -112.91, -173.94 47.41, 80.27 -93.43, 19.44 295.5, 80.71 -64.79, -26.04 in-in in 9.236 Saltbr-in 2.8108 HRD-in -68.59, -50.2 68.38, 8.36 in-in-in SNCiii in-in ActLoopNT-in 2.9607 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.65, 166.65 APE9-dihe-na 64.03, 159.2 APE8-dihe-in -80.26, 148.93 APE8-rot-in 296.57 APE67-dihe-in -70.89, -16.0 -37.06, -53.51 APE12-dist-in 12.7116 APE11-dist-in 10.3653 APE10-dist-in 6.1352 APE9-dist-in 3.3318 R21S,K74A,K75A,K76A None None XRAY 1.91 0.174 0.213 A 342.0 327.0 0 27 27 0 [[39, 324]] 1.0 5osp Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 9.4e-69 237.9 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OSRA P68400 3 329 391.0 ATP:403,AFK:404 ATPlike,Allosteric Active DFGin 7.3901 16.2349 BLAminus -115.2, -175.48 53.01, 75.53 -91.02, 17.2 296.18, 83.93 -66.77, -22.5 in-in in 9.1703 Saltbr-in 2.886 HRD-in -76.06, -46.71 67.27, 11.5 in-in-in SNCiii in-in ActLoopNT-in 2.9019 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.95, 170.87 APE9-dihe-na 60.56, 162.64 APE8-dihe-in -87.43, 145.48 APE8-rot-in 300.92 APE67-dihe-in -69.88, -13.97 -33.79, -56.46 APE12-dist-in 12.7267 APE11-dist-in 10.3646 APE10-dist-in 6.1844 APE9-dist-in 3.1669 R21S,K74A,K75A,K76A None None XRAY 1.57 0.177 0.209 A 342.0 327.0 0 27 27 0 [[39, 324]] 1.0 5osr Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 9.4e-69 237.9 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZY2A P68400 3 329 391.0 ATP:401,H4N:404,H4N:405 ATPlike,Allosteric,Allosteric Active DFGin 7.4672 16.2804 BLAminus -114.82, -177.5 55.14, 73.38 -87.5, 13.22 295.06, 80.66 -60.96, -25.13 in-in in 9.251 Saltbr-in 2.9307 HRD-in -72.23, -48.39 67.99, 7.65 in-in-in SNCiii in-in ActLoopNT-in 2.9304 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.44, 169.73 APE9-dihe-na 59.19, 155.39 APE8-dihe-in -76.55, 147.29 APE8-rot-in 280.93 APE67-dihe-in -68.75, -13.44 -39.25, -54.49 APE12-dist-in 12.6992 APE11-dist-in 10.3603 APE10-dist-in 6.1638 APE9-dist-in 3.2683 R21S,K74A,K75A,K76A None None XRAY 1.51 0.189 0.21 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 7zy2 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZYOA P68400 3 329 391.0 ATP:401,KEX:404,KEX:405 ATPlike,Allosteric,Allosteric Active DFGin 7.5021 16.3978 BLAminus -113.84, -177.01 53.93, 77.01 -92.97, 16.97 297.5, 80.44 -65.6, -20.61 in-in in 9.1968 Saltbr-in 2.9301 HRD-in -77.03, -47.55 70.73, 4.92 in-in-in SNCiii in-in ActLoopNT-in 2.8853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.4, 169.84 APE9-dihe-na 59.33, 166.07 APE8-dihe-in -87.44, 145.03 APE8-rot-in 291.2 APE67-dihe-in -67.16, -16.67 -36.15, -55.82 APE12-dist-in 12.7559 APE11-dist-in 10.6015 APE10-dist-in 6.1939 APE9-dist-in 3.2206 R21S,K74A,K75A,K76A None None XRAY 1.58 0.176 0.204 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 7zyo Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OS7B P68400 3 327 391.0 A8Q:402,ATP:403 Allosteric,ATPlike Active DFGin 7.4028 16.2864 BLAminus -113.36, -175.81 49.81, 80.69 -97.06, 16.82 294.27, 80.08 -65.25, -22.08 in-in in 9.4111 Saltbr-in 2.7974 HRD-in -70.47, -48.19 65.29, 14.71 in-in-in SNCiii in-in ActLoopNT-in 2.8567 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.46, 173.88 APE9-dihe-na 61.83, 168.57 APE8-dihe-in -97.24, 140.84 APE8-rot-in 297.98 APE67-dihe-in -62.16, -22.89 -29.44, -59.48 APE12-dist-in 12.6394 APE11-dist-in 10.3708 APE10-dist-in 6.0285 APE9-dist-in 3.1105 R21S None None XRAY 1.66 0.222 0.247 B 352.0 325.0 0 27 27 0 [[39, 324]] 1.0 5os7 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6GMDA P68400 3 327 391.0 A8Q:402,ATP:403 Allosteric,ATPlike Active DFGin 7.4028 16.2864 BLAminus -113.36, -175.81 49.81, 80.69 -97.06, 16.82 294.27, 80.08 -65.25, -22.08 in-in in 9.4111 Saltbr-in 2.7974 HRD-in -70.47, -48.19 65.29, 14.71 in-in-in SNCiii in-in ActLoopNT-in 2.8567 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.46, 173.88 APE9-dihe-na 61.83, 168.57 APE8-dihe-in -97.24, 140.84 APE8-rot-in 297.98 APE67-dihe-in -62.16, -21.58 -29.44, -59.48 APE12-dist-in 12.6394 APE11-dist-in 10.3708 APE10-dist-in 6.0285 APE9-dist-in 3.1105 R21S None None XRAY 1.66 0.222 0.247 A 352.0 325.0 0 27 27 0 [[39, 324]] 1.0 6gmd Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5CVFA P68400 3 329 391.0 54Z:401,ATP:402 Allosteric,ATPlike Active DFGin 7.4695 16.2682 BLAminus -117.2, -174.73 54.63, 71.77 -90.8, 22.72 298.48, 81.13 -69.82, -23.93 in-in in 9.2813 Saltbr-in 2.8202 HRD-in -73.12, -49.94 68.07, 7.39 in-in-in SNCiii in-in ActLoopNT-in 2.9183 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.49, 166.86 APE9-dihe-na 61.99, 156.53 APE8-dihe-in -74.21, 147.85 APE8-rot-in 294.94 APE67-dihe-in -65.44, -19.86 -39.38, -55.54 APE12-dist-in 12.6662 APE11-dist-in 10.3039 APE10-dist-in 6.173 APE9-dist-in 3.2513 R21S,K74A,K75A,K76A None None XRAY 1.63 0.201 0.209 A 328.0 325.0 2 27 27 0 [[39, 324]] 1.0 5cvf Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6FVFA P68400 3 329 391.0 503:401,ATP:402 Allosteric,ATPlike Inactive DFGin 7.4582 15.9956 BLAminus -117.08, -172.6 51.64, 74.63 -91.13, 21.7 296.66, 78.77 -67.99, -24.04 in-in in 9.3699 Saltbr-in 2.8041 HRD-in -73.47, -46.21 64.83, 11.56 in-in-out SNCiio in-out ActLoopNT-in 2.8599 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.11, 170.35 APE9-dihe-na 60.67, 163.08 APE8-dihe-in -84.61, 146.09 APE8-rot-out 196.52 APE67-dihe-in -71.22, -11.21 -34.5, -54.96 APE12-dist-in 12.7452 APE11-dist-in 10.4414 APE10-dist-in 6.2805 APE9-dist-in 3.1313 R21S,K74A,K75A,K76A None None XRAY 1.47 0.201 0.222 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 6fvf Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6FVGA P68400 3 329 391.0 E8K:401,ATP:402 Allosteric,ATPlike Inactive DFGin 7.5637 16.2487 BLAminus -114.12, -177.27 49.95, 79.39 -92.46, 19.09 295.44, 80.72 -62.08, -29.09 in-in in 9.4713 Saltbr-in 2.8666 HRD-in -71.26, -47.89 65.91, 11.22 in-in-out SNCiio in-out ActLoopNT-in 2.9197 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -131.37, 168.11 APE9-dihe-na 62.71, 167.0 APE8-dihe-in -87.82, 142.1 APE8-rot-out 201.01 APE67-dihe-in -70.04, -16.46 -32.6, -53.52 APE12-dist-in 12.9025 APE11-dist-in 10.5439 APE10-dist-in 6.3447 APE9-dist-in 3.2082 R21S,K74A,K75A,K76A None None XRAY 1.6 0.208 0.229 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 6fvg Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 8AEKA P68400 3 329 391.0 LVL:401,ATP:402 Allosteric,ATPlike Active DFGin 7.3593 16.189 BLAminus -116.05, -177.84 59.67, 69.99 -88.27, 14.27 295.52, 85.07 -64.38, -21.31 in-in in 9.2052 Saltbr-in 2.8162 HRD-in -74.44, -47.13 67.98, 9.84 in-in-in SNCiii in-in ActLoopNT-in 2.9283 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.41, 169.56 APE9-dihe-na 60.21, 157.69 APE8-dihe-in -79.56, 148.43 APE8-rot-in 292.83 APE67-dihe-in -70.07, -13.69 -40.23, -52.63 APE12-dist-in 12.6377 APE11-dist-in 10.3195 APE10-dist-in 6.099 APE9-dist-in 3.2103 R21S,K74A,K75A,K76A None None XRAY 1.65 0.173 0.198 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 8aek Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 8AEMA P68400 3 329 391.0 LVF:407,ATP:408 Allosteric,ATPlike Active DFGin 7.3989 16.1874 BLAminus -114.2, -178.47 56.21, 75.05 -90.39, 15.9 296.69, 81.8 -66.43, -20.83 in-in in 9.1318 Saltbr-in 2.816 HRD-in -72.91, -51.16 68.69, 11.11 in-in-in SNCiii in-in ActLoopNT-in 2.9049 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.83, 169.06 APE9-dihe-na 58.87, 157.76 APE8-dihe-in -77.1, 150.54 APE8-rot-in 294.73 APE67-dihe-in -68.78, -13.55 -40.19, -53.95 APE12-dist-in 12.7442 APE11-dist-in 10.4167 APE10-dist-in 6.256 APE9-dist-in 3.2152 R21S,K74A,K75A,K76A None None XRAY 1.6 0.19 0.212 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 8aem Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5CSHA P68400 4 327 391.0 54E:401,54E:402,ATP:403 Allosteric,Allosteric,ATPlike Active DFGin 7.4358 16.4754 BLAminus -114.33, -175.52 50.17, 77.83 -91.69, 16.93 295.31, 78.96 -64.52, -21.3 in-in in 9.6059 Saltbr-in 2.7982 HRD-in -72.7, -45.69 67.95, 9.72 in-in-in SNCiii in-in ActLoopNT-in 2.9615 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.3, 172.6 APE9-dihe-na 60.22, 166.59 APE8-dihe-in -92.85, 140.16 APE8-rot-in 301.7 APE67-dihe-in -64.39, -20.56 -30.14, -59.7 APE12-dist-in 12.5077 APE11-dist-in 10.2856 APE10-dist-in 6.0147 APE9-dist-in 3.087 R21S None None XRAY 1.59 0.194 0.207 A 352.0 324.0 0 27 27 0 [[39, 324]] 1.0 5csh Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5CSHB P68400 2 328 391.0 54E:403,54E:404,ATP:405 Allosteric,Allosteric,ATPlike Active DFGin 7.4434 16.2929 BLAminus -115.21, -175.71 50.61, 77.51 -92.19, 18.86 294.88, 77.24 -65.62, -21.94 in-in in 9.3656 Saltbr-in 2.7742 HRD-in -75.48, -46.24 69.71, 9.97 in-in-in SNCiii in-in ActLoopNT-in 2.9888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.44, 174.47 APE9-dihe-na 60.65, 166.44 APE8-dihe-in -96.7, 141.75 APE8-rot-in 305.79 APE67-dihe-in -65.63, -20.28 -30.96, -58.74 APE12-dist-in 12.5841 APE11-dist-in 10.4239 APE10-dist-in 6.0709 APE9-dist-in 3.1244 R21S None None XRAY 1.59 0.194 0.207 B 352.0 323.0 4 27 27 0 [[39, 324]] 1.0 5csh Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OS7A P68400 3 328 391.0 A8Q:404,A8Q:405,ATP:406 Allosteric,Allosteric,ATPlike Active DFGin 7.4641 16.0887 BLAminus -111.7, -175.06 51.27, 78.03 -95.04, 15.76 293.36, 80.0 -65.49, -19.43 in-in in 9.2077 Saltbr-in 2.7576 HRD-in -69.55, -50.38 66.74, 15.37 in-in-in SNCiii in-in ActLoopNT-in 2.8784 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.67, 175.58 APE9-dihe-na 57.11, 170.24 APE8-dihe-in -96.94, 142.73 APE8-rot-in 298.08 APE67-dihe-in -63.57, -23.25 -31.45, -59.13 APE12-dist-in 12.6625 APE11-dist-in 10.3794 APE10-dist-in 6.1745 APE9-dist-in 3.1323 R21S None None XRAY 1.66 0.222 0.247 A 352.0 326.0 0 27 27 0 [[39, 324]] 1.0 5os7 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6GMDB P68400 3 328 391.0 A8Q:404,A8Q:405,ATP:406 Allosteric,Allosteric,ATPlike Active DFGin 7.4641 16.0887 BLAminus -111.7, -175.06 51.27, 78.03 -95.04, 15.76 293.36, 80.0 -65.49, -19.43 in-in in 9.2077 Saltbr-in 2.7576 HRD-in -69.55, -50.38 66.74, 15.37 in-in-in SNCiii in-in ActLoopNT-in 2.8784 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.67, 175.58 APE9-dihe-na 57.11, 170.24 APE8-dihe-in -96.94, 142.73 APE8-rot-in 298.08 APE67-dihe-in -63.57, -23.25 -31.45, -59.13 APE12-dist-in 12.6625 APE11-dist-in 10.3794 APE10-dist-in 6.1745 APE9-dist-in 3.1323 R21S None None XRAY 1.66 0.222 0.247 B 352.0 326.0 0 27 27 0 [[39, 324]] 1.0 6gmd Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OS8A P68400 3 329 391.0 J27:404,J27:405,J27:406,ATP:407 Allosteric,Allosteric,Allosteric,ATPlike Active DFGin 7.4504 16.1456 BLAminus -116.36, -176.24 53.52, 76.44 -92.27, 17.36 295.25, 83.47 -66.45, -20.94 in-in in 9.2323 Saltbr-in 2.7892 HRD-in -76.31, -47.96 70.56, 8.8 in-in-in SNCiii in-in ActLoopNT-in 2.9016 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.3, 166.93 APE9-dihe-na 62.26, 151.31 APE8-dihe-in -76.68, 145.67 APE8-rot-in 296.22 APE67-dihe-in -69.08, -13.55 -36.03, -55.39 APE12-dist-in 12.6668 APE11-dist-in 10.3086 APE10-dist-in 6.187 APE9-dist-in 3.3128 R21S,K74A,K75A,K76A None None XRAY 1.55 0.178 0.201 A 328.0 327.0 0 27 27 0 [[39, 324]] 1.0 5os8 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OTRA P68400 3 329 391.0 AU8:403,AU8:404,AU8:405,ATP:406 Allosteric,Allosteric,Allosteric,ATPlike Active DFGin 7.4677 16.2824 BLAminus -118.34, -175.14 53.67, 73.1 -89.26, 15.26 295.08, 81.83 -61.86, -25.81 in-in in 9.3647 Saltbr-in 2.9513 HRD-in -75.87, -45.88 70.89, 5.51 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.59, 162.52 APE9-dihe-na 63.44, 152.89 APE8-dihe-in -75.69, 144.57 APE8-rot-in 311.11 APE67-dihe-in -70.25, -15.02 -34.48, -55.38 APE12-dist-in 12.8086 APE11-dist-in 10.5696 APE10-dist-in 6.3392 APE9-dist-in 3.6067 R21S,K74A,K75A,K76A None None XRAY 1.52 0.18 0.202 A 342.0 327.0 0 27 27 0 [[39, 324]] 1.0 5otr Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 9.4e-69 237.9 1.0 301.0 301.0 174 175 176 178 180 68 81 85 153 155 154 156.0 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
OTHER TTK TTK_HUMAN 3HMNA P33981 516 794 857.0 ATP:1 ATPlike Inactive DFGin 3.9993 14.9908 ABAminus -98.05, -9.81 -153.31, 160.67 -110.5, 6.35 307.22, 150.55 69.66, 19.48 out-out out 10.962 Saltbr-out 6.5276 HRD-in -68.45, -50.57 72.29, 2.18 out-out-out SNCooo out-out ActLoopNT-out 11.6458 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 102.39 APE9-dihe-na -78.34, -151.63 APE8-dihe-in -168.7, 144.18 APE8-rot-in 299.37 APE67-dihe-in -66.82, -19.22 -122.77, 14.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.6219 APE9-dist-out 12.1907 None None None XRAY 2.7 0.223 0.265 A 342.0 255.0 24 30 18 12 [[525, 791]] 1.0 3hmn Homo sapiens OTHER_TTK_HUMAN CAMK 1.1e-53 188.1 1.0 256.0 256.0 663 664 665 667 669 553 571 575 644 646 645 647.0 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
RGC NPR1 ANPRA_HUMAN 9BCOA P16066 498 1053 1061.0 ATP:61101 ATPlike Pseudo DFGin 6.5001 14.8279 BLBplus -89.25, -164.06 42.72, 55.71 -135.24, 156.32 73.6, 95.91 78.22, -166.07 out-none out 16.9277 Saltbr-none 999.0 HRD-out -74.2, 156.17 -59.96, -57.76 none-out-out SNCnoo out-out ActLoopNT-out 12.0137 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -68.12, -1.53 APE9-dihe-na -60.93, -51.9 APE8-dihe-in -129.45, 85.23 APE8-rot-none 999.0 APE67-dihe-in -58.29, -38.75 -145.34, 13.28 APE12-dist-out 23.5741 APE11-dist-out 20.4302 APE10-dist-out 24.5499 APE9-dist-out 15.8581 None None None EM 4.4 999.0 999.0 A 1040.0 521.0 21 28 28 0 [[539, 803]] 1.0 9bco Homo sapiens RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6.0 265.0 260.0 677 678 679 681 683 567 583 587 657 659 658 660.0 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCOB P16066 501 1053 1061.0 ATP:61101 ATPlike Pseudo DFGin 6.0349 14.0501 BLBplus -88.95, 166.99 56.44, 21.66 -61.11, 145.38 64.96, 87.18 86.53, -116.67 out-none out 15.4543 Saltbr-none 999.0 HRD-in -114.17, -53.78 98.92, -43.57 none-out-out SNCnoo out-out ActLoopNT-out 9.4468 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_oooo APE10-dihe-na -52.94, -51.71 APE9-dihe-na -111.55, -27.36 APE8-dihe-out -110.69, 11.24 APE8-rot-none 999.0 APE67-dihe-in -47.42, -35.74 -121.93, -1.95 APE12-dist-out 18.2038 APE11-dist-out 21.2106 APE10-dist-out 24.218 APE9-dist-out 14.7064 None None None EM 4.4 999.0 999.0 B 1040.0 517.0 22 28 28 0 [[539, 803]] 1.0 9bco Homo sapiens RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6.0 265.0 260.0 677 678 679 681 683 567 583 587 657 659 658 660.0 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCPA P16066 505 842 1061.0 ATP:61101 ATPlike Pseudo DFGin 5.2758 13.4991 BLBplus -119.01, 147.56 55.81, 47.24 -98.35, -175.13 72.56, 101.5 63.71, -113.08 out-none out 15.017 Saltbr-none 999.0 HRD-in -101.28, -53.45 85.86, -1.89 none-out-out SNCnoo out-out ActLoopNT-out 10.0607 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -56.32, -46.22 APE9-dihe-na -56.3, -35.86 APE8-dihe-out -106.06, -11.55 APE8-rot-na 74.77 APE67-dihe-in -55.12, -26.01 -77.38, -2.19 APE12-dist-out 20.6504 APE11-dist-out 18.4713 APE10-dist-out 23.005 APE9-dist-out 14.3286 None None None EM 4.1 999.0 999.0 A 1040.0 314.0 21 28 28 0 [[539, 803]] 1.0 9bcp Homo sapiens RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6.0 265.0 260.0 677 678 679 681 683 567 583 587 657 659 658 660.0 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCPB P16066 503 841 1061.0 ATP:61101 ATPlike Pseudo DFGin 5.3555 16.7605 BLBtrans -138.66, -167.01 55.46, 41.07 -76.35, 89.03 193.7, 109.94 60.64, -128.0 out-none out 16.6488 Saltbr-none 999.0 HRD-out -58.73, 127.47 -87.85, -41.33 none-out-out SNCnoo out-out ActLoopNT-out 12.1834 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na -63.64, -13.04 APE9-dihe-na -73.26, -45.78 APE8-dihe-out -94.47, 23.47 APE8-rot-na 181.32 APE67-dihe-out -126.85, -50.61 -149.46, 92.68 APE12-dist-out 22.3611 APE11-dist-out 19.6779 APE10-dist-out 23.708 APE9-dist-out 15.4009 None None None EM 4.1 999.0 999.0 B 1040.0 304.0 21 28 28 0 [[539, 803]] 1.0 9bcp Homo sapiens RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6.0 265.0 260.0 677 678 679 681 683 567 583 587 657 659 658 660.0 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCSA P16066 503 1055 1061.0 ATP:61100 ATPlike Pseudo DFGin 7.6937 15.7366 None -74.51, -65.19 38.98, 36.73 -149.34, 137.28 313.08, 80.76 -109.19, -24.55 out-none out 17.3363 Saltbr-none 999.0 HRD-in -67.46, -13.34 80.4, -46.04 none-out-out SNCnoo out-out ActLoopNT-out 11.4528 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -59.39, -44.12 APE9-dihe-na -70.77, -47.95 APE8-dihe-out -62.03, -25.18 APE8-rot-na 74.24 APE67-dihe-in -57.49, -15.22 -74.7, -41.95 APE12-dist-out 24.0207 APE11-dist-out 19.7602 APE10-dist-out 23.1609 APE9-dist-out 13.3465 None None None EM 4.4 999.0 999.0 A 1040.0 515.0 23 28 28 0 [[539, 803]] 1.0 9bcs Homo sapiens RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6.0 265.0 260.0 677 678 679 681 683 567 583 587 657 659 658 660.0 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCSB P16066 505 1055 1061.0 ATP:61100 ATPlike Pseudo None 999.0 999.0 None -84.33, 145.87 61.52, 18.75 -86.58, 62.78 999.0, 999.0 166.38, -163.08 out-none out 16.2736 Saltbr-none 999.0 HRD-in -63.93, -40.93 80.49, -6.63 none-out-out SNCnoo out-out ActLoopNT-out 11.2318 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_oooo APE10-dihe-na -65.87, -23.07 APE9-dihe-na -84.75, -47.21 APE8-dihe-out -94.13, -13.59 APE8-rot-none 999.0 APE67-dihe-in -66.6, -21.85 -106.41, 28.83 APE12-dist-out 21.8814 APE11-dist-out 20.4057 APE10-dist-out 24.7198 APE9-dist-out 14.2606 None None None EM 4.4 999.0 999.0 B 1040.0 523.0 25 28 28 0 [[539, 803]] 1.0 9bcs Homo sapiens RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6.0 265.0 260.0 677 678 679 681 683 567 583 587 657 659 658 660.0 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
STE MAP2K1 MP2K1_HUMAN 4AN3A Q02750 61 381 393.0 ATP:61383,5Y0:61384 ATPlike,Type3 Inactive DFGin 6.3723 14.221 BLBplus -129.12, 178.33 68.61, 30.98 -85.55, 168.03 44.05, 86.92 -96.2, 75.38 out-out out 15.6935 Saltbr-out 15.4163 HRD-in -67.68, -62.51 95.67, -17.38 out-out-out SNCooo out-out ActLoopNT-out 9.2297 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_onno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -140.36 APE8-dihe-in -98.61, 79.73 APE8-rot-in 326.73 APE67-dihe-in -67.76, -12.96 -73.18, -22.73 APE12-dist-out 17.69 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.352 S218E,S222E,G328A None None XRAY 2.1 0.229 0.283 A 301.0 277.0 2 26 24 2 [[68, 361]] 1.0 4an3 Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-99 338.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3OS3A Q02750 62 378 393.0 ATP:1,3OS:400 ATPlike,Type3 Inactive DFGin 6.2398 13.5344 BLBplus -145.24, 170.05 62.26, 36.89 -93.68, 158.58 44.13, 99.29 -73.81, 106.93 out-out out 15.5039 Saltbr-out 15.3944 HRD-in -59.5, -62.21 84.93, 3.41 out-out-out SNCooo out-out ActLoopNT-out 9.408 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -133.7, -173.12 APE9-dihe-na 93.3, -146.81 APE8-dihe-out -139.28, -26.49 APE8-rot-out 64.05 APE67-dihe-out 179.14, 100.5 -105.07, -165.97 APE12-dist-out 14.8647 APE11-dist-out 20.0987 APE10-dist-out 20.8465 APE9-dist-out 14.0001 None None None XRAY 2.8 0.268 0.356 A 307.0 272.0 13 26 26 0 [[68, 361]] 1.0 3os3 Homo sapiens STE_MAP2K1_HUMAN STE 9.7e-99 335.8 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3DV3A Q02750 62 382 393.0 ATP:69000,MEK:69001 ATPlike,Type3 Inactive DFGin 6.2483 13.6028 BLBplus -133.16, -177.92 60.69, 33.15 -89.5, 161.32 45.46, 91.05 -72.95, 66.6 out-out out 15.44 Saltbr-out 15.9198 HRD-in -71.02, -56.25 85.34, -10.2 out-out-out SNCooo out-out ActLoopNT-out 9.4338 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 147.19 APE8-dihe-out -113.44, 8.55 APE8-rot-out 63.26 APE67-dihe-out -136.65, 142.85 -161.65, 147.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.7228 None None None XRAY 2.3 0.184 0.221 A 322.0 287.0 34 26 23 3 [[68, 361]] 1.0 3dv3 Homo sapiens STE_MAP2K1_HUMAN STE 1.2e-97 332.2 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3PP1A Q02750 62 382 393.0 ATP:60400,IZG:60500 ATPlike,Type3 Inactive DFGin 6.2434 13.5326 BLBplus -142.73, -172.37 57.21, 29.66 -83.48, 161.89 45.19, 86.92 -94.1, 95.51 out-out out 15.5755 Saltbr-out 15.6643 HRD-in -75.88, -59.97 91.29, -12.92 out-out-out SNCooo out-out ActLoopNT-out 9.8367 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -95.93, 115.09 APE9-dihe-na -80.03, 20.28 APE8-dihe-out -149.74, -167.9 APE8-rot-out 183.56 APE67-dihe-out -104.62, 136.28 16.12, 99.01 APE12-dist-out 17.8027 APE11-dist-out 17.6574 APE10-dist-out 19.8725 APE9-dist-out 14.6223 None None None XRAY 2.7 0.184 0.219 A 328.0 290.0 31 26 26 0 [[68, 361]] 1.0 3pp1 Homo sapiens STE_MAP2K1_HUMAN STE 1.3e-97 332.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3EQBA Q02750 62 382 393.0 ATP:69001,LUG:60001 ATPlike,Type3 Inactive DFGin 6.3666 13.8165 BLBplus -126.21, -166.87 50.54, 41.27 -103.19, 173.93 44.2, 81.11 -86.45, 70.56 out-out out 15.5513 Saltbr-out 16.0995 HRD-in -69.12, -59.32 92.15, -13.52 out-out-out SNCooo out-out ActLoopNT-out 9.4116 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -145.13 APE9-dihe-na 160.93, -130.46 APE8-dihe-out -134.08, -9.84 APE8-rot-out 185.08 APE67-dihe-out -100.78, 136.47 -136.54, 109.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.269 APE9-dist-out 13.0736 None None None XRAY 2.62 0.212 0.264 A 333.0 288.0 33 26 23 3 [[68, 361]] 1.0 3eqb Homo sapiens STE_MAP2K1_HUMAN STE 1.4e-97 332.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 1S9JA Q02750 62 382 393.0 ATP:60535,BBM:61001 ATPlike,Type3 Inactive DFGin 6.0381 13.6765 BLBplus -128.29, 177.35 60.26, 51.07 -106.68, 166.27 42.89, 83.29 -88.36, 87.09 out-out out 15.6483 Saltbr-out 16.0046 HRD-in -74.19, -52.1 76.2, -2.79 out-out-out SNCooo out-out ActLoopNT-out 9.3469 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -65.48 APE9-dihe-na 93.04, 154.36 APE8-dihe-out -82.85, 11.58 APE8-rot-out 188.1 APE67-dihe-out -101.56, 129.66 -130.71, 111.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.1483 APE9-dist-out 12.5588 None None None XRAY 2.4 0.246 0.269 A 341.0 288.0 33 26 23 3 [[68, 361]] 1.0 1s9j Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3DY7A Q02750 62 364 393.0 ATP:9000,1CX:9002 ATPlike,Type3 Inactive DFGin 6.1717 13.7583 BLBplus -135.89, -175.79 54.31, 45.87 -100.93, 164.77 46.33, 84.08 -87.96, 76.55 out-out out 15.2441 Saltbr-out 15.5792 HRD-in -80.68, -50.01 86.81, -10.3 out-out-out SNCooo out-out ActLoopNT-out 9.4633 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -93.77 APE8-dihe-out -68.47, -78.94 APE8-rot-in 288.45 APE67-dihe-out -129.83, 139.32 -78.41, 146.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.0637 None None None XRAY 2.7 0.248 0.269 A 341.0 260.0 43 26 23 3 [[68, 361]] 1.0 3dy7 Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3E8NA Q02750 62 382 393.0 ATP:60600,VRA:61001 ATPlike,Type3 Inactive DFGin 6.1947 13.8185 BLBplus -141.11, 177.37 57.45, 45.25 -100.77, 153.06 46.07, 82.11 -71.63, 93.26 out-out out 15.4133 Saltbr-out 15.3475 HRD-in -66.77, -56.92 83.67, -13.1 out-out-out SNCooo out-out ActLoopNT-out 9.4321 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_onoo APE10-dihe-na 999.0, -90.03 APE9-dihe-na 88.43, 141.27 APE8-dihe-out -49.1, -69.8 APE8-rot-out 147.13 APE67-dihe-out -116.51, 140.9 -59.5, 122.62 APE12-dist-out 18.8826 APE11-dist-none 999.0 APE10-dist-out 19.9857 APE9-dist-out 12.8311 None None None XRAY 2.5 0.219 0.252 A 341.0 290.0 31 26 25 1 [[68, 361]] 1.0 3e8n Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3VVHA Q02750 62 382 393.0 ATP:60702,4BM:60703 ATPlike,Type3 Inactive DFGin 6.3887 13.6564 BLBplus -137.53, 173.5 63.48, 33.18 -82.96, 158.78 37.49, 96.63 -83.81, 69.64 out-out out 15.318 Saltbr-out 14.9475 HRD-in -72.04, -55.34 81.65, -10.46 out-out-out SNCooo out-out ActLoopNT-out 9.2611 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -67.32 APE8-rot-in 311.04 APE67-dihe-out -121.47, 130.33 -95.91, 138.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.199 0.225 A 341.0 286.0 35 26 21 5 [[68, 361]] 1.0 3vvh Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3VVHB Q02750 62 382 393.0 ATP:60502,4BM:60503 ATPlike,Type3 Inactive DFGin 6.1391 13.837 BLBplus -134.79, 175.55 59.54, 35.53 -87.99, 165.28 42.27, 92.99 -92.68, 76.34 out-out out 15.2611 Saltbr-out 14.9773 HRD-in -72.52, -58.36 78.03, -3.83 out-out-out SNCooo out-out ActLoopNT-out 9.105 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -110.08, 147.03 APE9-dihe-na 98.19, 168.29 APE8-dihe-out -85.55, -32.58 APE8-rot-in 303.1 APE67-dihe-out -124.7, 138.59 -110.8, 145.07 APE12-dist-out 16.9705 APE11-dist-out 20.5595 APE10-dist-out 18.8507 APE9-dist-out 12.9264 None None None XRAY 2.0 0.199 0.225 B 341.0 289.0 32 26 26 0 [[68, 361]] 1.0 3vvh Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3VVHC Q02750 62 381 393.0 ATP:60502,4BM:60503 ATPlike,Type3 Inactive DFGin 6.1194 13.8842 BLBplus -136.04, 173.19 62.4, 33.8 -87.32, 164.72 43.72, 90.03 -81.06, 61.43 out-out out 15.3952 Saltbr-out 14.9059 HRD-in -71.92, -60.52 80.82, -10.24 out-out-out SNCooo out-out ActLoopNT-out 9.0055 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -107.33, 145.59 APE9-dihe-na 98.43, 176.47 APE8-dihe-out -99.48, -17.12 APE8-rot-out 62.73 APE67-dihe-out -124.21, 136.5 -120.29, 144.56 APE12-dist-out 16.9183 APE11-dist-out 20.6229 APE10-dist-out 18.8043 APE9-dist-out 12.9647 None None None XRAY 2.0 0.199 0.225 C 341.0 282.0 38 26 26 0 [[68, 361]] 1.0 3vvh Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 2P55A Q02750 62 382 393.0 MRA:69000,ATP:69001 Type3,ATPlike Inactive DFGin 6.1626 13.3824 BLBplus -134.23, -173.95 50.87, 43.67 -95.4, 166.24 42.0, 89.87 -87.86, 76.42 out-out out 15.2177 Saltbr-out 15.3456 HRD-in -70.81, -55.41 89.6, -22.02 out-out-out SNCooo out-out ActLoopNT-out 9.468 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -78.03 APE9-dihe-na 94.66, -135.55 APE8-dihe-out -131.47, -8.61 APE8-rot-out 200.5 APE67-dihe-out -121.47, 132.61 -102.76, 124.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.1744 APE9-dist-out 13.9789 None None None XRAY 2.8 0.228 0.301 A 333.0 288.0 33 26 23 3 [[68, 361]] 1.0 2p55 Homo sapiens STE_MAP2K1_HUMAN STE 1.4e-97 332.1 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3V01A Q02750 62 382 393.0 3V0:60501,ATP:60502 Type3,ATPlike Inactive DFGin 6.105 13.4244 BLBplus -142.06, -173.42 54.59, 34.91 -91.82, 163.8 47.01, 90.27 -88.09, 75.03 out-out out 15.5642 Saltbr-out 15.7785 HRD-in -62.64, -63.68 88.6, -7.02 out-out-out SNCooo out-out ActLoopNT-out 9.2768 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -67.65 APE9-dihe-na 102.3, -166.23 APE8-dihe-out -116.29, 3.8 APE8-rot-out 189.24 APE67-dihe-out -108.4, 130.42 -142.07, 120.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.0771 APE9-dist-out 12.8379 None None None XRAY 2.705 0.189 0.24 A 341.0 288.0 33 26 23 3 [[68, 361]] 1.0 3v01 Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3V04A Q02750 62 382 393.0 V04:60501,ATP:60502 Type3,ATPlike Inactive DFGin 6.2019 13.4656 BLBplus -139.99, -177.53 54.26, 36.29 -92.6, 163.3 43.17, 90.4 -92.7, 75.2 out-out out 15.6131 Saltbr-out 16.0488 HRD-in -56.82, -58.2 81.63, -6.31 out-out-out SNCooo out-out ActLoopNT-out 9.1096 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -43.92 APE9-dihe-na 143.86, 160.52 APE8-dihe-out -85.24, -10.44 APE8-rot-out 182.43 APE67-dihe-out -103.47, 130.39 -134.15, 117.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.8085 APE9-dist-out 12.649 None None None XRAY 2.7 0.213 0.243 A 341.0 288.0 33 26 23 3 [[68, 361]] 1.0 3v04 Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K2 MP2K2_HUMAN 1S9IA P36507 60 393 400.0 ATP:535,5EA:1001 ATPlike,Type3 Inactive DFGin 6.2872 13.2689 BLBplus -139.34, -174.92 56.51, 21.27 -79.15, 150.55 47.45, 91.25 -79.77, 85.37 out-out out 15.5294 Saltbr-out 17.2975 HRD-out -62.14, 153.21 -129.12, 19.13 out-out-out SNCooo out-out ActLoopNT-out 8.8978 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnoo APE10-dihe-na 999.0, 134.1 APE9-dihe-na -103.89, 62.93 APE8-dihe-out -65.91, -35.32 APE8-rot-in 354.81 APE67-dihe-out -93.63, 150.37 -174.34, 119.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 21.6182 APE9-dist-out 12.7323 None None None XRAY 3.2 0.294 0.364 A 354.0 303.0 31 26 22 4 [[72, 369]] 1.0 1s9i Homo sapiens STE_MAP2K2_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 211 212 213 215 217 101 118 122 191 193 192 194.0 249 237 232 231 230 229 228 227 226 148 Dual specificity mitogen-activated protein kinase kinase 2
STE MAP2K2 MP2K2_HUMAN 1S9IB P36507 59 389 400.0 ATP:537,5EA:1002 ATPlike,Type3 Inactive DFGin 6.2824 13.6383 BLBplus -139.5, 161.8 56.55, 60.44 -106.38, 150.17 37.7, 87.0 -78.89, 77.21 out-out out 15.5341 Saltbr-out 15.0044 HRD-out -92.42, 79.21 -68.62, 14.72 out-out-out SNCooo out-out ActLoopNT-out 9.5166 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -33.93 APE8-rot-out 15.08 APE67-dihe-out -144.19, 132.88 -117.04, 157.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.294 0.364 B 354.0 291.0 40 26 20 6 [[72, 369]] 1.0 1s9i Homo sapiens STE_MAP2K2_HUMAN STE 1.5e-97 331.9 1.0 257.0 257.0 211 212 213 215 217 101 118 122 191 193 192 194.0 249 237 232 231 230 229 228 227 226 148 Dual specificity mitogen-activated protein kinase kinase 2
STE PAK1 PAK1_HUMAN 3Q53A Q13153 250 541 545.0 ATP:1 ATPlike None DFGin 6.5457 15.9679 BLAminus -131.41, -173.51 59.18, 73.62 -91.64, 12.88 288.75, 75.16 -60.67, -19.44 out-none out 10.1595 Saltbr-none 999.0 HRD-in -69.79, -48.58 76.19, -3.19 none-in-in SNCnii in-in ActLoopNT-in 2.8373 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.58, -17.38 APE9-dihe-na -66.64, 179.65 APE8-dihe-in -103.57, 123.03 APE8-rot-in 305.32 APE67-dihe-in -60.91, -26.26 -42.88, -52.15 APE12-dist-in 8.284 APE11-dist-in 10.4631 APE10-dist-in 4.7272 APE9-dist-in 3.4382 K299R,L516I TPO423 TPO423 XRAY 2.09 0.207 0.223 A 306.0 292.0 0 28 28 0 [[270, 521]] 1.0 3q53 Homo sapiens STE_PAK1_HUMAN STE 2.5e-94 321.4 1.0 257.0 257.0 406 407 408 410 412 299 315 319 386 388 387 389.0 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK4 PAK4_HUMAN 4XBRA O96013 177 589 591.0 ATP:60601 ATPlike Inactive DFGin 5.8522 14.0612 ABAminus -142.04, -22.23 -111.42, 72.59 -86.56, 10.51 310.81, 99.4 -46.84, -40.66 in-in in 7.0094 Saltbr-in 3.1584 HRD-in -84.11, -33.57 58.48, -1.88 in-in-in SNCiii in-in ActLoopNT-in 2.9736 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.96, 132.02 APE9-dihe-na 150.85, -176.82 APE8-dihe-in -102.34, 122.5 APE8-rot-in 312.14 APE67-dihe-in -59.91, -25.15 -35.82, -60.88 APE12-dist-in 9.3349 APE11-dist-in 11.9274 APE10-dist-in 6.0495 APE9-dist-in 3.3957 None SEP474 SEP474 XRAY 2.94 0.191 0.23 A 366.0 293.0 0 28 28 0 [[321, 572]] 1.0 4xbr Homo sapiens STE_PAK4_HUMAN STE 3.7e-88 301.2 5.0 257.0 253.0 457 458 459 461 463 350 366 370 437 439 438 440.0 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE STK24 STK24_HUMAN 3A7HA Q9Y6E0 18 310 443.0 ATP:60400 ATPlike Inactive DFGin 6.2741 16.0602 BLAminus -135.27, 174.99 54.48, 64.86 -70.71, -58.08 287.78, 76.92 45.88, -44.99 in-out in 9.7224 Saltbr-out 4.4927 HRD-in -66.74, -51.36 77.62, -11.47 out-in-in SNCoii in-in ActLoopNT-in 2.7975 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.61, 151.93 APE9-dihe-na 118.1, -167.87 APE8-dihe-in -108.64, 120.02 APE8-rot-in 324.07 APE67-dihe-in -58.13, -27.9 -30.96, -56.98 APE12-dist-in 8.2692 APE11-dist-in 11.1373 APE10-dist-in 5.5434 APE9-dist-in 3.5657 None TPO190 TPO190 XRAY 1.96 0.21 0.252 A 303.0 290.0 0 28 28 0 [[36, 286]] 1.0 3a7h Homo sapiens STE_STK24_HUMAN STE 3.6e-100 340.5 1.0 257.0 257.0 173 174 175 177 179 65 82 86 153 155 154 156.0 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 3A7HB Q9Y6E0 17 310 443.0 ATP:60400 ATPlike Inactive DFGin 6.6847 16.8596 BLAminus -138.1, 177.76 56.48, 71.8 -87.83, 21.17 281.85, 78.43 -54.77, -28.24 out-out out 10.376 Saltbr-out 4.6392 HRD-in -73.68, -49.41 75.79, -7.51 out-in-in SNCoii in-in ActLoopNT-in 2.8157 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.6, 158.04 APE9-dihe-na 117.1, -164.51 APE8-dihe-in -112.27, 119.11 APE8-rot-in 308.97 APE67-dihe-in -56.45, -30.21 -34.32, -55.35 APE12-dist-in 8.2153 APE11-dist-in 11.0119 APE10-dist-in 5.2611 APE9-dist-in 3.4012 None TPO190 TPO190 XRAY 1.96 0.21 0.252 B 303.0 291.0 0 28 28 0 [[36, 286]] 1.0 3a7h Homo sapiens STE_STK24_HUMAN STE 3.6e-100 340.5 1.0 257.0 257.0 173 174 175 177 179 65 82 86 153 155 154 156.0 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STRADA STRAA_HUMAN 3GNIB Q7RTN6 60 431 431.0 ATP:60001 ATPlike Pseudo DFGin 5.2283 13.3577 BLAminus -109.39, -155.43 74.77, 29.57 -67.06, -15.75 299.34, 10.06 -54.98, -34.79 in-none in 9.8996 Saltbr-none 999.0 HRD-in -71.88, -63.47 83.33, 4.11 none-in-out SNCnio in-out ActLoopNT-in 2.866 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_iooo APE10-dihe-na -73.5, 108.36 APE9-dihe-na 128.9, -33.16 APE8-dihe-out -82.37, -8.26 APE8-rot-na 193.56 APE67-dihe-in -56.7, -25.37 -48.29, -50.45 APE12-dist-in 8.5274 APE11-dist-out 7.0984 APE10-dist-out 12.8989 APE9-dist-out 9.8974 None None None XRAY 2.35 0.207 0.254 B 389.0 290.0 56 35 35 0 [[69, 379]] 1.0 3gni Homo sapiens STE_STRADA_HUMAN STE 4.7e-87 297.8 1.0 257.0 257.0 212 213 214 216 218 100 118 122 192 194 193 195.0 261 247 242 241 240 239 238 237 236 148 STE20-related kinase adapter protein alpha
TKL ILK ILK_HUMAN 9D5IA Q13418 182 452 452.0 ATP:502 ATPlike Pseudo DFGinter 8.2613 6.8416 None -85.91, 104.5 -70.94, -26.25 -67.8, 1.23 999.0, 999.0 -109.51, 3.6 out-out out 13.6108 Saltbr-out 13.7768 HRD-out 63.45, 28.98 -91.0, 110.88 out-out-out SNCooo out-out ActLoopNT-out 6.365 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioo APE10-dihe-na -132.95, 115.89 APE9-dihe-na -99.41, -2.16 APE8-dihe-in -138.47, 54.8 APE8-rot-none 999.0 APE67-dihe-in -62.49, -23.03 -64.85, -19.12 APE12-dist-out 14.7048 APE11-dist-in 13.9898 APE10-dist-out 13.1384 APE9-dist-out 13.2651 R225A,C346S,C422S None None XRAY 1.5 0.23 0.267 A 271.0 271.0 0 23 23 0 [[192, 448]] 1.0 9d5i Homo sapiens TKL_ILK_HUMAN TKL 2.8e-62 216.7 3.0 267.0 265.0 336 337 338 340 342 220 238 242 316 318 317 319.0 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 3KMWA Q13418 185 452 452.0 ATP:502 ATPlike Pseudo DFGinter 8.2996 6.9752 None -80.97, 99.65 -67.11, -24.75 -72.37, 0.55 999.0, 999.0 -103.25, 4.58 out-out out 13.4961 Saltbr-out 14.0409 HRD-out 59.64, 26.4 -91.04, 116.86 out-out-out SNCooo out-out ActLoopNT-out 6.3674 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -122.08, 118.72 APE9-dihe-na -100.74, -5.98 APE8-dihe-in -137.53, 58.2 APE8-rot-none 999.0 APE67-dihe-in -63.57, -23.06 -67.47, -16.05 APE12-dist-out 14.7099 APE11-dist-out 14.0404 APE10-dist-out 13.057 APE9-dist-out 13.0267 C346S,C422S None None XRAY 2.0 0.199 0.203 A 271.0 268.0 0 23 23 0 [[192, 448]] 1.0 3kmw Homo sapiens TKL_ILK_HUMAN TKL 1.5e-62 217.5 3.0 267.0 265.0 336 337 338 340 342 220 238 242 316 318 317 319.0 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 3REPA Q13418 185 452 452.0 ATP:502 ATPlike Pseudo DFGinter 8.264 6.8945 None -81.35, 101.61 -70.12, -25.38 -69.18, -5.31 999.0, 999.0 -98.03, -0.84 out-out out 13.3586 Saltbr-out 14.1198 HRD-out 62.24, 23.62 -86.21, 112.03 out-out-out SNCooo out-out ActLoopNT-out 6.4539 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioo APE10-dihe-na -114.84, 122.73 APE9-dihe-na -97.69, -5.36 APE8-dihe-in -136.02, 58.25 APE8-rot-none 999.0 APE67-dihe-in -57.73, -27.19 -63.83, -23.69 APE12-dist-out 14.4979 APE11-dist-in 13.9809 APE10-dist-out 12.9395 APE9-dist-out 13.101 C346S,C422S None None XRAY 1.8 0.206 0.238 A 271.0 268.0 0 23 23 0 [[192, 448]] 1.0 3rep Homo sapiens TKL_ILK_HUMAN TKL 1.5e-62 217.5 3.0 267.0 265.0 336 337 338 340 342 220 238 242 316 318 317 319.0 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL KSR2 KSR2_HUMAN 2Y4IB Q6VAB6 653 931 950.0 ATP:1932 ATPlike Pseudo DFGin 6.0393 13.3572 BLBplus -163.04, 167.92 56.95, 32.67 -75.07, 155.41 46.1, 92.34 53.05, 51.5 out-none out 15.5798 Saltbr-none 999.0 HRD-in -80.25, -38.53 67.56, -67.09 none-out-out SNCnoo out-out ActLoopNT-out 10.4303 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -56.45, -137.53 APE9-dihe-na -67.8, 7.84 APE8-dihe-out -54.46, -37.41 APE8-rot-na 170.99 APE67-dihe-in -92.05, 13.42 -60.84, -28.22 APE12-dist-out 17.417 APE11-dist-out 14.5757 APE10-dist-out 17.158 APE9-dist-out 12.2619 None None None XRAY 3.46 0.233 0.293 B 319.0 265.0 14 33 23 10 [[665, 930]] 1.0 2y4i Homo sapiens TKL_KSR2_HUMAN TKL 1.1e-70 244.1 2.0 267.0 266.0 802 803 804 806 808 692 710 714 783 785 784 786.0 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL LRRK2 LRRK2_HUMAN 8FO9A Q5S007 1329 2527 2527.0 ATP:2602 ATPlike Active DFGin 6.2733 13.4102 BLAminus -138.23, -175.7 59.6, 64.71 -84.85, 53.99 305.84, 101.34 -78.49, -28.55 in-in in 7.8797 Saltbr-in 2.7348 HRD-in -107.83, -47.31 66.25, 1.81 in-in-in SNCiii in-in ActLoopNT-in 3.031 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.21, 156.34 APE9-dihe-na 139.24, 152.96 APE8-dihe-in -67.96, 127.7 APE8-rot-in 305.42 APE67-dihe-inflip 98.56, -16.69 -58.5, 136.92 APE12-dist-in 9.1834 APE11-dist-in 11.4868 APE10-dist-in 6.0039 APE9-dist-in 3.8159 None None None EM 3.48 999.0 999.0 A 2527.0 1173.0 0 26 26 0 [[1875, 2134]] 1.0 8fo9 Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO9C Q5S007 1329 2527 2527.0 ATP:2602 ATPlike Active DFGin 6.2753 13.4053 BLAminus -138.14, -175.77 59.5, 64.85 -84.95, 53.97 305.9, 101.31 -78.52, -28.52 in-in in 7.8828 Saltbr-in 2.7293 HRD-in -108.59, -47.2 66.33, 1.76 in-in-in SNCiii in-in ActLoopNT-in 3.008 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.94, 156.21 APE9-dihe-na 139.37, 152.96 APE8-dihe-in -67.92, 127.71 APE8-rot-in 305.58 APE67-dihe-inflip 98.46, -16.81 -58.61, 136.94 APE12-dist-in 9.1767 APE11-dist-in 11.5032 APE10-dist-in 6.012 APE9-dist-in 3.8041 None None None EM 3.48 999.0 999.0 C 2527.0 1173.0 0 26 26 0 [[1875, 2134]] 1.0 8fo9 Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LHTA Q5S007 558 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 9.8435 8.2947 None -64.84, 122.35 -98.75, -0.04 -71.37, -28.28 172.84, 65.91 -59.04, -42.88 out-out out 11.1561 Saltbr-out 7.8414 HRD-in -69.75, -40.92 72.72, -9.61 out-out-out SNCooo out-out ActLoopNT-out 9.7836 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -82.21, -17.19 APE9-dihe-na 90.26, 154.46 APE8-dihe-in -57.7, 141.99 APE8-rot-in 318.57 APE67-dihe-in -63.97, -43.36 -55.36, -52.39 APE12-dist-in 9.6726 APE11-dist-in 10.1449 APE10-dist-out 14.0961 APE9-dist-in 4.0969 None None None EM 3.5 999.0 999.0 A 2527.0 1795.0 3 26 23 3 [[1875, 2134]] 1.0 7lht Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LHTB Q5S007 558 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 9.8435 8.2947 None -64.86, 122.35 -98.72, -0.04 -71.37, -28.3 172.84, 65.9 -59.09, -42.88 out-out out 11.1564 Saltbr-out 7.8415 HRD-in -69.81, -40.92 72.73, -9.55 out-out-out SNCooo out-out ActLoopNT-out 9.783 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -82.22, -17.15 APE9-dihe-na 90.23, 154.47 APE8-dihe-in -57.69, 142.03 APE8-rot-in 318.55 APE67-dihe-in -64.0, -43.36 -55.37, -52.4 APE12-dist-in 9.6725 APE11-dist-in 10.1447 APE10-dist-out 14.096 APE9-dist-in 4.0969 None None None EM 3.5 999.0 999.0 B 2527.0 1795.0 3 26 23 3 [[1875, 2134]] 1.0 7lht Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LHWA Q5S007 540 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 10.3492 8.2774 None -70.88, 117.76 -93.02, 2.5 -63.92, -24.19 170.47, 59.39 -60.34, -43.84 out-out out 10.98 Saltbr-out 7.2575 HRD-in -74.65, -33.87 72.74, -12.12 out-out-out SNCooo out-out ActLoopNT-out 9.6308 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -74.42, -8.25 APE9-dihe-na 81.17, 153.49 APE8-dihe-in -58.6, 142.93 APE8-rot-in 304.43 APE67-dihe-in -63.74, -43.48 -51.59, -53.96 APE12-dist-in 10.2362 APE11-dist-in 9.4572 APE10-dist-out 13.8716 APE9-dist-in 4.3352 None None None EM 3.7 999.0 999.0 A 2527.0 1813.0 3 26 23 3 [[1875, 2134]] 1.0 7lhw Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LI4A Q5S007 558 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 9.8442 8.2944 None -64.77, 122.33 -98.76, -0.03 -71.41, -28.21 172.83, 65.95 -59.02, -42.88 out-out out 11.1566 Saltbr-out 7.8416 HRD-in -69.78, -40.92 72.72, -9.67 out-out-out SNCooo out-out ActLoopNT-out 9.7838 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -82.19, -17.19 APE9-dihe-na 90.26, 154.48 APE8-dihe-in -57.73, 142.01 APE8-rot-in 318.58 APE67-dihe-in -63.98, -43.36 -55.36, -52.38 APE12-dist-in 9.6727 APE11-dist-in 10.1448 APE10-dist-out 14.0958 APE9-dist-in 4.0959 None None None EM 3.1 999.0 999.0 A 2527.0 1795.0 3 26 23 3 [[1875, 2134]] 1.0 7li4 Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO2E Q5S007 12 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 10.5492 8.1829 None -77.97, 115.31 -99.8, 16.1 -71.24, -24.34 179.0, 61.54 -64.41, -41.78 out-out out 11.347 Saltbr-out 7.8505 HRD-in -73.2, -35.27 72.81, -10.29 out-out-out SNCooo out-out ActLoopNT-out 9.492 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -67.29, -18.03 APE9-dihe-na 75.0, 160.57 APE8-dihe-in -64.56, 133.01 APE8-rot-in 300.63 APE67-dihe-in -63.84, -35.14 -59.88, -35.03 APE12-dist-in 9.1186 APE11-dist-in 10.5881 APE10-dist-out 14.4472 APE9-dist-in 4.3818 None None None EM 4.13 999.0 999.0 E 2527.0 2275.0 4 26 23 3 [[1875, 2134]] 1.0 8fo2 Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO8C Q5S007 12 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 10.4041 8.3667 None -77.76, 115.2 -99.79, 16.57 -70.68, -24.12 178.89, 61.58 -64.22, -41.72 out-out out 11.3412 Saltbr-out 7.7439 HRD-in -73.07, -35.29 72.76, -10.32 out-out-out SNCooo out-out ActLoopNT-out 9.4707 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -67.5, -18.26 APE9-dihe-na 74.89, 160.43 APE8-dihe-in -64.77, 133.4 APE8-rot-in 300.66 APE67-dihe-in -63.6, -35.05 -59.67, -34.64 APE12-dist-in 9.0713 APE11-dist-in 10.5217 APE10-dist-out 14.4112 APE9-dist-in 4.4488 None None None EM 3.88 999.0 999.0 C 2527.0 2270.0 4 26 23 3 [[1875, 2134]] 1.0 8fo8 Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO8E Q5S007 12 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 10.4146 8.3493 None -77.68, 115.13 -99.83, 16.55 -70.64, -24.07 178.91, 61.52 -64.18, -41.73 out-out out 11.3208 Saltbr-out 7.7298 HRD-in -73.0, -35.27 72.87, -10.42 out-out-out SNCooo out-out ActLoopNT-out 9.4702 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -67.4, -18.35 APE9-dihe-na 74.93, 160.44 APE8-dihe-in -64.61, 133.34 APE8-rot-in 300.72 APE67-dihe-in -63.56, -35.05 -59.56, -34.8 APE12-dist-in 9.056 APE11-dist-in 10.5258 APE10-dist-out 14.406 APE9-dist-in 4.4342 None None None EM 3.88 999.0 999.0 E 2527.0 2270.0 4 26 23 3 [[1875, 2134]] 1.0 8fo8 Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO9F Q5S007 12 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 9.3478 8.5752 None -68.36, 152.72 -137.53, 18.95 -81.54, -22.77 187.88, 51.61 -70.19, -36.74 out-out out 11.2379 Saltbr-out 8.3264 HRD-in -76.93, -42.26 72.06, -11.17 out-out-out SNCooo out-out ActLoopNT-out 9.1058 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -70.82, -18.07 APE9-dihe-na 87.94, 175.98 APE8-dihe-in -63.48, 135.16 APE8-rot-in 300.23 APE67-dihe-in -66.37, -45.6 -58.88, -37.04 APE12-dist-in 9.7177 APE11-dist-in 10.5775 APE10-dist-out 14.122 APE9-dist-in 4.4728 None None None EM 3.48 999.0 999.0 F 2527.0 2289.0 3 26 23 3 [[1875, 2134]] 1.0 8fo9 Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LI3A Q5S007 558 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 9.5831 8.4031 None -64.7, 121.5 -105.97, 8.82 -69.04, -26.41 175.66, 65.26 -63.25, -46.61 out-out out 11.4013 Saltbr-out 8.1206 HRD-in -76.04, -34.97 73.14, -12.04 out-out-out SNCooo out-out ActLoopNT-out 9.6644 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -85.32, -9.76 APE9-dihe-na 87.27, 160.92 APE8-dihe-in -56.79, 143.13 APE8-rot-in 300.33 APE67-dihe-in -63.35, -39.62 -56.92, -55.07 APE12-dist-in 10.3855 APE11-dist-in 10.3625 APE10-dist-out 14.0058 APE9-dist-in 3.6521 None None None EM 3.8 999.0 999.0 A 2527.0 1795.0 3 26 23 3 [[1875, 2134]] 1.0 7li3 Homo sapiens TKL_LRRK2_HUMAN TKL 3.9e-56 197.0 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO9E Q5S007 12 2527 2527.0 ATP:2602 ATPlike Inactive DFGout 11.3745 7.913 None -68.54, 152.71 -137.53, 21.65 -90.85, -9.64 146.2, 91.59 -82.02, -36.47 out-out out 11.1602 Saltbr-out 8.209 HRD-in -76.97, -42.35 72.15, -11.11 out-out-out SNCooo out-out ActLoopNT-out 9.123 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -70.77, -18.05 APE9-dihe-na 87.91, 175.95 APE8-dihe-in -63.49, 135.16 APE8-rot-in 300.24 APE67-dihe-in -66.44, -45.65 -58.78, -37.14 APE12-dist-in 9.6513 APE11-dist-in 10.5523 APE10-dist-out 14.083 APE9-dist-in 4.472 None None None EM 3.48 999.0 999.0 E 2527.0 2287.0 3 26 23 3 [[1875, 2134]] 1.0 8fo9 Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5.0 266.0 262.0 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994.0 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TYR EGFR EGFR_HUMAN 8PO4B P00533 700 1014 1210.0 ATP:1101 ATPlike Inactive DFGin 5.6238 16.3937 BLBtrans -121.3, 175.63 63.19, 26.9 -63.92, 138.21 163.94, 68.04 83.38, -10.03 out-out out 13.6 Saltbr-out 13.0291 HRD-in -73.28, -55.5 80.32, -14.85 out-out-out SNCooo out-out ActLoopNT-out 6.4864 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 119.23 APE8-dihe-in -81.98, 63.66 APE8-rot-na 32.98 APE67-dihe-in -71.84, -8.05 -50.66, -40.3 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.2552 V948R None None XRAY 1.621 0.211 0.243 B 328.0 295.0 20 30 17 13 [[712, 970]] 1.0 8po4 Homo sapiens TYR_EGFR_HUMAN TYR 7.9e-88 300.2 3.0 259.0 257.0 854 855 856 858 860 745 762 766 834 836 835 837.0 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR INSR INSR_HUMAN 3BU5A P06213 1014 1310 1382.0 ATP:60300 ATPlike Active DFGin 6.6591 13.9339 BLAminus -128.64, -166.6 44.54, 89.54 -102.81, 23.91 295.82, 99.34 -57.5, -34.18 in-in in 8.2612 Saltbr-in 3.1304 HRD-in -68.86, -51.91 77.02, -10.33 in-in-in SNCiii in-in ActLoopNT-in 2.8444 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.0, 102.51 APE9-dihe-in -127.85, 151.44 APE8-dihe-in -79.76, 69.1 APE8-rot-na 32.47 APE67-dihe-in -66.77, -8.03 -57.27, -41.89 APE12-dist-na 15.9367 APE11-dist-na 11.7238 APE10-dist-na 11.3004 APE9-dist-in 7.4014 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 2.1 0.196 0.239 A 306.0 294.0 3 30 30 0 [[1023, 1292]] 1.0 3bu5 Homo sapiens TYR_INSR_HUMAN TYR 1.3e-96 328.8 1.0 260.0 260.0 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159.0 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR JAK2-1 JAK2_HUMAN 5I4NA O60674 537 809 1132.0 ATP:61000 ATPlike Pseudo DFGin 5.6682 13.3858 None -68.19, 172.29 -64.41, 158.19 -73.31, -26.63 342.84, 34.8 77.82, -169.16 out-na out 11.405 Saltbr-na 999.0 HRD-in -78.6, -60.98 86.96, 3.87 na-out-out SNCaoo out-out ActLoopNT-out 8.6814 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.12, -41.49 APE9-dihe-out -58.18, -29.35 APE8-dihe-out -88.11, 6.74 APE8-rot-na 290.83 APE67-dihe-out -103.83, 26.01 -65.06, 135.53 APE12-dist-na 10.0371 APE11-dist-na 11.7 APE10-dist-na 16.2781 APE9-dist-out 12.3723 E596A,V617F,W659A,W777A,F794H None None XRAY 1.54 0.174 0.193 A 290.0 273.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 5i4n Homo sapiens TYR_JAK2-1_HUMAN TYR 7.1e-64 221.5 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 4FVRA O60674 536 809 1132.0 ATP:901 ATPlike Pseudo DFGin 5.7656 13.3758 None -77.86, -178.54 -72.61, 163.95 -75.06, -27.39 334.11, 39.64 77.27, -166.65 out-na out 11.7821 Saltbr-na 999.0 HRD-in -74.66, -57.27 90.8, -3.55 na-out-out SNCaoo out-out ActLoopNT-out 8.5367 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.48, -33.68 APE9-dihe-out -63.8, -34.8 APE8-dihe-out -85.1, 11.44 APE8-rot-na 293.02 APE67-dihe-out -101.64, 24.24 -66.8, 135.55 APE12-dist-na 9.675 APE11-dist-na 11.4734 APE10-dist-na 16.0369 APE9-dist-out 12.0279 V617F,W777A,F794H None None XRAY 2.0 0.183 0.229 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 4fvr Homo sapiens TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 4FVQA O60674 536 809 1132.0 ATP:901 ATPlike Pseudo DFGin 6.4109 13.5312 None -82.38, -178.3 -71.29, 157.18 -64.23, -31.16 342.38, 32.32 77.45, -167.94 out-na out 10.3574 Saltbr-na 999.0 HRD-in -81.79, -59.57 93.66, -10.87 na-out-out SNCaoo out-out ActLoopNT-out 9.0941 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.14, -35.28 APE9-dihe-out -67.39, -22.98 APE8-dihe-out -92.26, 6.93 APE8-rot-na 290.03 APE67-dihe-out -106.47, 27.81 -64.4, 133.6 APE12-dist-na 9.9123 APE11-dist-na 11.4873 APE10-dist-na 16.0746 APE9-dist-out 12.3782 W659A,W777A,F794H None None XRAY 1.75 0.176 0.199 A 289.0 274.0 0 24 24 0 [[545, 807], [849, 1125]] 2.0 4fvq Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C08A O60674 537 810 1132.0 ATP:901 ATPlike Pseudo DFGin 6.5983 13.736 None -72.21, 176.69 -66.6, 164.57 -72.8, -15.2 349.18, 27.02 73.34, -163.25 in-na in 9.3998 Saltbr-na 999.0 HRD-in -80.72, -74.63 111.24, -16.83 na-out-out SNCaoo out-out ActLoopNT-out 9.4736 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -55.86, -37.52 APE9-dihe-out -72.05, -28.92 APE8-dihe-out -74.69, -10.21 APE8-rot-na 283.12 APE67-dihe-out -93.42, 18.23 -54.81, 139.34 APE12-dist-na 9.9203 APE11-dist-na 11.8594 APE10-dist-na 16.3524 APE9-dist-out 12.5304 W659A,W777A,F794H None None XRAY 2.2 0.267 0.259 A 289.0 270.0 4 24 24 0 [[545, 807], [849, 1125]] 2.0 8c08 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C08B O60674 536 810 1132.0 ATP:901 ATPlike Pseudo DFGin 5.6459 13.5394 None -63.04, -178.12 -72.48, 164.14 -59.19, -39.37 337.51, 34.58 89.58, -173.09 out-na out 12.1784 Saltbr-na 999.0 HRD-in -76.08, -63.96 89.49, 0.26 na-out-out SNCaoo out-out ActLoopNT-out 8.7296 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.09, -36.29 APE9-dihe-out -67.21, -14.45 APE8-dihe-out -97.09, 0.9 APE8-rot-na 279.42 APE67-dihe-out -95.31, 21.21 -63.75, 135.54 APE12-dist-na 10.8478 APE11-dist-na 11.8372 APE10-dist-na 16.5999 APE9-dist-out 12.658 W659A,W777A,F794H None None XRAY 2.2 0.267 0.259 B 289.0 269.0 6 24 24 0 [[545, 807], [849, 1125]] 2.0 8c08 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2.0 260.0 259.0 698 699 700 702 704 581 597 601 670 672 671 673.0 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR MET MET_HUMAN 3DKCA P08581 1051 1360 1390.0 ATP:60001 ATPlike Inactive DFGin 5.6932 13.1031 BLBplus -128.11, 162.74 67.51, 17.44 -61.67, 130.17 44.2, 92.69 80.08, -22.94 out-out out 14.0828 Saltbr-out 12.8365 HRD-in -71.17, -57.45 82.5, -22.81 out-out-out SNCooo out-out ActLoopNT-out 7.7392 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -83.24, -9.16 APE9-dihe-in -104.14, 150.23 APE8-dihe-in -75.82, 62.17 APE8-rot-na 30.64 APE67-dihe-in -64.7, -18.65 -61.74, -26.11 APE12-dist-na 18.5297 APE11-dist-na 20.199 APE10-dist-na 15.662 APE9-dist-out 9.0723 Y1194F,Y1234F,Y1235D None None XRAY 1.52 0.189 0.218 A 317.0 310.0 0 32 32 0 [[1078, 1339]] 1.0 3dkc Homo sapiens TYR_MET_HUMAN TYR 8.6e-90 306.9 2.0 260.0 259.0 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204.0 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR PTK2 FAK1_HUMAN 2IJMA Q05397 414 688 1052.0 ATP:690 ATPlike Inactive DFGin 5.3348 15.2552 None -130.4, -10.41 -96.6, 92.35 -115.09, 154.36 308.92, 97.78 84.66, -9.12 in-in in 7.6024 Saltbr-in 2.5443 HRD-in -77.84, -47.69 90.07, -21.21 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -43.55 APE8-dihe-in -70.98, 54.52 APE8-rot-na 26.91 APE67-dihe-in -71.31, -14.5 -49.75, -42.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.5309 None None None XRAY 2.187 0.211 0.271 A 281.0 260.0 15 29 14 15 [[422, 678]] 1.0 2ijm Homo sapiens TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1.0 260.0 260.0 563 564 565 567 569 454 471 475 543 545 544 546.0 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TKL RIPK A0A811MC32_9POAL 8HOAA A0A811MC32 90 387 441.0 ATP:60701,HX2:60702 ATPlike,Allosteric Inactive DFGin 6.0609 12.6057 BLBplus -114.97, 161.69 65.77, 20.85 -71.65, 141.67 50.94, 88.04 74.58, 5.91 out-none out 13.156 Saltbr-none 999.0 HRD-out -77.34, 149.41 -82.88, -37.27 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 19.65 APE8-dihe-out -73.34, -23.03 APE8-rot-out 81.86 APE67-dihe-out 95.0, 11.7 -84.03, -15.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.2055 None None None XRAY 1.676 0.188 0.213 A 326.0 271.0 27 30 14 16 [[105, 385]] 1.0 8hoa Miscanthus lutarioriparius TKL_RIPK_9POAL TKL 1.9e-59 207.4 4.0 266.0 263.0 253 254 255 257 259 141 157 161 233 235 234 236.0 295 283 278 277 276 275 274 273 272 187 non-specific serine/threonine protein kinase
AGC PRKACA KAPCA_MOUSE 1ATPE P05132 16 351 351.0 ATP:60355 ATPlike Inactive DFGin 6.2296 14.5876 BLAminus -105.27, -165.6 48.73, 87.06 -105.12, 16.76 267.19, 75.22 -52.19, -32.07 in-out in 9.1613 Saltbr-out 3.6341 HRD-in -88.29, -43.64 51.81, 19.16 out-in-in SNCoii in-in ActLoopNT-in 2.8078 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.21, 146.28 APE9-dihe-na 146.09, -156.15 APE8-dihe-in -133.3, 119.84 APE8-rot-in 299.98 APE67-dihe-in -65.71, -15.81 -24.26, -60.76 APE12-dist-in 8.3526 APE11-dist-in 11.4096 APE10-dist-in 5.7064 APE9-dist-in 3.9902 None TPO198,SEP339 TPO198,SEP339 XRAY 2.2 0.177 999.0 E 350.0 336.0 0 25 25 0 [[44, 298]] 1.0 1atp Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3FJQE P05132 16 351 351.0 ATP:60403 ATPlike Active DFGin 5.6709 14.4589 BLAminus -119.42, 178.78 63.28, 80.04 -91.81, 23.31 270.73, 57.82 -56.09, -30.86 in-in in 9.1494 Saltbr-in 2.8344 HRD-in -91.33, -52.39 67.42, 13.87 in-in-in SNCiii in-in ActLoopNT-in 2.9056 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.19, 160.44 APE9-dihe-na 133.42, -155.21 APE8-dihe-in -125.75, 136.86 APE8-rot-in 304.0 APE67-dihe-in -61.0, -22.29 -48.87, -49.39 APE12-dist-in 8.0863 APE11-dist-in 11.4084 APE10-dist-in 5.8377 APE9-dist-in 3.5179 None TPO198,SEP339 TPO198,SEP339 XRAY 1.6 0.179 0.205 E 350.0 336.0 0 25 25 0 [[44, 298]] 1.0 3fjq Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DH1A P05132 16 351 351.0 ATP:60402 ATPlike Active DFGin 6.2341 14.3802 BLAminus -130.7, 167.11 69.97, 89.08 -103.01, 26.92 273.93, 57.95 -52.62, -33.38 in-in in 8.9305 Saltbr-in 3.0104 HRD-in -75.69, -51.31 65.95, 10.85 in-in-in SNCiii in-in ActLoopNT-in 2.8868 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.97, 163.54 APE9-dihe-na 128.87, -151.55 APE8-dihe-in -123.52, 135.53 APE8-rot-in 304.09 APE67-dihe-in -55.69, -26.94 -40.23, -59.36 APE12-dist-in 8.1686 APE11-dist-in 11.5574 APE10-dist-in 5.9503 APE9-dist-in 3.5446 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.0 0.199 0.234 A 350.0 336.0 0 25 25 0 [[44, 298]] 1.0 4dh1 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DH3A P05132 16 351 351.0 ATP:60403 ATPlike Active DFGin 5.9838 14.3792 BLAminus -125.47, 176.75 61.82, 79.89 -92.16, 24.39 276.69, 54.39 -43.39, -47.09 in-in in 9.021 Saltbr-in 2.7225 HRD-in -82.56, -48.22 66.04, -2.33 in-in-in SNCiii in-in ActLoopNT-in 2.9311 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.47, 165.55 APE9-dihe-na 126.96, -149.27 APE8-dihe-in -125.58, 130.88 APE8-rot-in 307.35 APE67-dihe-in -57.88, -25.54 -37.95, -56.15 APE12-dist-in 8.2249 APE11-dist-in 11.5925 APE10-dist-in 6.1036 APE9-dist-in 3.74 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.2 0.203 0.233 A 350.0 336.0 0 25 25 0 [[44, 298]] 1.0 4dh3 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DINA P05132 10 351 351.0 ATP:60400 ATPlike Inactive DFGin 5.792 13.1437 BLAminus -127.84, -176.29 51.22, 102.02 -109.69, 31.05 287.96, 58.2 -47.08, -31.2 in-in in 8.5177 Saltbr-in 3.4979 HRD-out -64.69, -78.02 71.93, 51.46 in-in-out SNCiio in-out ActLoopNT-in 2.9942 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -152.73, 153.23 APE9-dihe-na 130.84, -154.91 APE8-dihe-in -121.15, 137.05 APE8-rot-out 34.65 APE67-dihe-in -46.77, -45.03 -45.98, -63.1 APE12-dist-in 7.9722 APE11-dist-in 10.5875 APE10-dist-in 4.9968 APE9-dist-in 3.53 None TPO198,SEP339 TPO198,SEP339 XRAY 3.7 0.211 0.293 A 350.0 342.0 0 25 25 0 [[44, 298]] 1.0 4din Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4X6RA P05132 2 351 351.0 ATP:60402 ATPlike Active DFGin 6.1334 14.2323 BLAminus -118.92, 178.27 64.18, 79.91 -89.21, 11.01 274.1, 55.74 -49.19, -34.95 in-in in 8.8037 Saltbr-in 2.7288 HRD-in -85.13, -60.38 77.67, -7.87 in-in-in SNCiii in-in ActLoopNT-in 2.7182 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.34, 156.01 APE9-dihe-na 147.33, -149.7 APE8-dihe-in -130.56, 138.51 APE8-rot-in 291.09 APE67-dihe-in -61.2, -24.8 -52.44, -47.95 APE12-dist-in 8.281 APE11-dist-in 11.2462 APE10-dist-in 5.8359 APE9-dist-in 3.6632 K8C SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.4 0.186 0.234 A 350.0 350.0 0 25 25 0 [[44, 298]] 1.0 4x6r Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3X2UA P05132 13 351 351.0 ATP:60501 ATPlike Active DFGin 6.1271 14.5072 BLAminus -122.24, 178.58 59.36, 87.7 -101.54, 25.28 272.61, 50.83 -59.45, -24.26 in-in in 9.2723 Saltbr-in 2.7882 HRD-in -89.58, -50.62 64.84, 17.58 in-in-in SNCiii in-in ActLoopNT-in 2.9297 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.25, 158.3 APE9-dihe-na 134.88, -147.54 APE8-dihe-in -130.4, 131.58 APE8-rot-in 300.12 APE67-dihe-in -61.26, -14.4 -40.08, -55.22 APE12-dist-in 7.9122 APE11-dist-in 11.1375 APE10-dist-in 5.6863 APE9-dist-in 3.4266 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.4 0.202 0.239 A 357.0 339.0 0 25 25 0 [[44, 298]] 1.0 3x2u Mus musculus AGC_PRKACA_MOUSE AGC 1.6e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3X2VA P05132 18 351 351.0 ATP:60403 ATPlike Active DFGin 5.5167 14.1516 BLAminus -116.69, -175.94 62.92, 80.3 -91.77, 26.26 271.42, 55.44 -51.78, -39.79 in-in in 8.7552 Saltbr-in 2.6541 HRD-in -92.08, -50.84 67.69, 17.07 in-in-in SNCiii in-in ActLoopNT-in 2.8813 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.85, 164.45 APE9-dihe-na 134.14, -152.5 APE8-dihe-in -130.83, 133.42 APE8-rot-in 299.77 APE67-dihe-in -58.82, -21.18 -48.96, -48.11 APE12-dist-in 7.9982 APE11-dist-in 11.3458 APE10-dist-in 5.7964 APE9-dist-in 3.4149 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.77 0.185 0.23 A 357.0 334.0 0 25 25 0 [[44, 298]] 1.0 3x2v Mus musculus AGC_PRKACA_MOUSE AGC 1.6e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3X2WA P05132 13 351 351.0 ATP:60403 ATPlike Active DFGin 5.6602 14.3902 BLAminus -121.01, -177.68 63.51, 77.56 -90.4, 24.79 270.4, 59.29 -61.83, -28.06 in-in in 8.8217 Saltbr-in 2.6324 HRD-in -81.34, -52.24 70.22, 11.48 in-in-in SNCiii in-in ActLoopNT-in 2.9059 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.19, 162.39 APE9-dihe-na 132.4, -151.44 APE8-dihe-in -129.91, 133.08 APE8-rot-in 300.2 APE67-dihe-in -60.45, -20.83 -45.18, -51.38 APE12-dist-in 8.001 APE11-dist-in 11.4403 APE10-dist-in 5.911 APE9-dist-in 3.4498 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.7 0.165 0.198 A 357.0 339.0 0 25 25 0 [[44, 298]] 1.0 3x2w Mus musculus AGC_PRKACA_MOUSE AGC 1.6e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4XW5A P05132 15 351 351.0 ATP:60403 ATPlike Active DFGin 5.971 14.2215 BLAminus -131.24, 177.82 59.66, 87.19 -93.08, 25.08 282.37, 63.43 -53.77, -29.24 in-in in 9.2129 Saltbr-in 2.673 HRD-in -90.87, -48.94 63.52, 13.92 in-in-in SNCiii in-in ActLoopNT-in 2.8122 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.24, 155.03 APE9-dihe-na 137.47, -160.98 APE8-dihe-in -110.31, 133.6 APE8-rot-in 304.05 APE67-dihe-in -58.14, -25.36 -48.87, -50.12 APE12-dist-in 8.0264 APE11-dist-in 11.6005 APE10-dist-in 6.1002 APE9-dist-in 3.9217 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.95 0.185 0.252 A 356.0 337.0 0 25 25 0 [[44, 298]] 1.0 4xw5 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3QAME P05132 2 351 351.0 ATP:60351 ATPlike Active DFGin 5.5585 14.1896 BLAminus -125.2, -173.2 57.82, 79.24 -94.32, 24.42 273.28, 56.46 -52.36, -33.22 in-in in 8.9798 Saltbr-in 2.8042 HRD-in -80.54, -55.75 67.52, 12.49 in-in-in SNCiii in-in ActLoopNT-in 2.8883 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.45, 157.56 APE9-dihe-na 134.84, -152.56 APE8-dihe-in -129.9, 127.65 APE8-rot-in 298.13 APE67-dihe-in -57.31, -20.14 -26.19, -66.74 APE12-dist-in 8.0939 APE11-dist-in 11.2769 APE10-dist-in 5.8065 APE9-dist-in 3.475 E209A TPO198,SEP339 TPO198,SEP339 XRAY 1.92 0.195 0.228 E 350.0 350.0 0 25 25 0 [[44, 298]] 1.0 3qam Mus musculus AGC_PRKACA_MOUSE AGC 2.2e-93 318.2 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3QALE P05132 2 351 351.0 ATP:60351 ATPlike Active DFGin 5.6399 14.4013 BLAminus -123.21, -177.09 59.31, 80.89 -94.71, 25.93 269.1, 56.43 -54.28, -32.32 in-in in 9.0502 Saltbr-in 2.6578 HRD-in -84.64, -51.07 65.64, 14.74 in-in-in SNCiii in-in ActLoopNT-in 2.9615 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.61, 159.73 APE9-dihe-na 131.58, -155.18 APE8-dihe-in -126.66, 132.34 APE8-rot-in 301.51 APE67-dihe-in -57.77, -23.32 -31.31, -63.36 APE12-dist-in 8.0621 APE11-dist-in 11.3091 APE10-dist-in 5.7435 APE9-dist-in 3.5307 R281A TPO198,SEP339 TPO198,SEP339 XRAY 1.7 0.176 0.194 E 350.0 341.0 0 25 25 0 [[44, 298]] 1.0 3qal Mus musculus AGC_PRKACA_MOUSE AGC 4.5e-93 317.2 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 1RDQE P05132 2 351 351.0 ADP:60599,ATP:60600 ATPlike,ATPlike Active DFGin 5.7065 14.5148 BLAminus -117.27, 178.71 64.74, 81.19 -90.07, 21.82 270.96, 52.48 -58.25, -31.62 in-in in 9.0905 Saltbr-in 2.719 HRD-in -91.16, -53.36 73.19, 12.39 in-in-in SNCiii in-in ActLoopNT-in 2.9357 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.91, 159.57 APE9-dihe-na 132.64, -151.85 APE8-dihe-in -127.7, 133.09 APE8-rot-in 298.45 APE67-dihe-in -59.33, -27.24 -47.42, -47.34 APE12-dist-in 8.1158 APE11-dist-in 11.4138 APE10-dist-in 5.8307 APE9-dist-in 3.5208 Y205A TPO198,SEP339 TPO198,SEP339 XRAY 1.26 0.132 0.162 E 350.0 342.0 0 25 25 0 [[44, 298]] 1.0 1rdq Mus musculus AGC_PRKACA_MOUSE AGC 1.1e-92 315.9 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CAMK DAPK2 DAPK2_MOUSE 2YAAA Q8VDF3 12 311 370.0 ATP:61302 ATPlike Active DFGin 6.5313 14.2817 BLAminus -119.44, -173.75 61.63, 82.55 -100.44, 26.82 279.23, 73.82 -61.71, -30.38 in-in in 9.4366 Saltbr-in 2.945 HRD-in -69.91, -51.35 70.12, 4.4 in-in-in SNCiii in-in ActLoopNT-in 2.8304 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.66, 179.02 APE9-dihe-na 88.17, 165.82 APE8-dihe-in -83.03, 124.75 APE8-rot-in 307.34 APE67-dihe-in -54.24, -28.42 -45.93, -43.89 APE12-dist-in 8.6787 APE11-dist-in 11.5917 APE10-dist-in 6.3906 APE9-dist-in 4.9265 None None None XRAY 2.3 0.219 0.271 A 361.0 300.0 0 27 27 0 [[23, 285]] 1.0 2yaa Mus musculus CAMK_DAPK2_MOUSE CAMK 1.1e-93 319.4 1.0 256.0 256.0 170 171 172 174 176 52 74 78 146 148 147 149.0 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_MOUSE 2YAAB Q8VDF3 13 311 370.0 ATP:61302 ATPlike Inactive DFGin 6.5837 14.2887 BLAminus -119.54, -178.65 66.98, 88.67 -108.71, 24.01 280.41, 69.43 -62.37, -28.55 out-out out 10.1706 Saltbr-out 5.3765 HRD-in -72.87, -55.45 75.11, 6.49 out-in-in SNCoii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -174.59, 179.36 APE9-dihe-na 81.98, 166.79 APE8-dihe-in -83.03, 125.4 APE8-rot-in 303.87 APE67-dihe-in -54.18, -26.93 -45.18, -48.55 APE12-dist-in 8.7637 APE11-dist-in 11.5959 APE10-dist-in 6.4302 APE9-dist-in 4.8282 None None None XRAY 2.3 0.219 0.271 B 361.0 299.0 0 27 27 0 [[23, 285]] 1.0 2yaa Mus musculus CAMK_DAPK2_MOUSE CAMK 1.1e-93 319.4 1.0 256.0 256.0 170 171 172 174 176 52 74 78 146 148 147 149.0 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CMGC MAPK14 MK14_MOUSE 7Z9TBBB P47811 4 353 360.0 87B:401,ATP:402 Type3,Allosteric Inactive DFGin 5.8293 15.2444 BLBminus -103.34, -178.81 25.47, 89.69 -68.87, -161.65 315.54, 109.9 -76.7, 116.65 out-out out 10.3417 Saltbr-out 4.1791 HRD-in -67.82, -70.27 93.09, -17.91 out-out-out SNCooo out-out ActLoopNT-out 7.706 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -124.01, -67.71 APE9-dihe-na -98.04, -13.3 APE8-dihe-out -67.58, -39.12 APE8-rot-in 311.0 APE67-dihe-in -63.55, -21.3 -74.81, -8.77 APE12-dist-out 14.5958 APE11-dist-out 16.3559 APE10-dist-out 19.3522 APE9-dist-out 12.5383 None None None XRAY 2.6 0.202 0.254 BBB 359.0 350.0 0 25 25 0 [[24, 308]] 1.0 7z9t Mus musculus CMGC_MAPK14_MOUSE CMGC 5e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
STE STK39 STK39_MOUSE 5D9HA Q9Z1W9 65 363 556.0 ATP:501 ATPlike Inactive DFGin 5.6858 16.4373 BLBtrans -110.31, 163.68 60.83, 61.1 -112.91, 152.73 160.61, 82.83 89.94, -129.86 out-out out 13.6821 Saltbr-out 14.1755 HRD-in -79.34, -55.51 78.38, -0.69 out-out-out SNCooo out-out ActLoopNT-out 7.7526 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 89.3 APE9-dihe-na 145.31, -162.33 APE8-dihe-in -128.36, 135.86 APE8-rot-out 189.19 APE67-dihe-in -54.38, -21.28 -96.66, 16.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 27.0541 APE9-dist-out 28.5465 None None None XRAY 3.1 0.24 0.269 A 348.0 290.0 9 33 26 7 [[75, 349]] 1.0 5d9h Mus musculus STE_STK39_MOUSE STE 1.3e-90 309.2 1.0 257.0 257.0 221 222 223 225 227 104 121 125 201 203 202 204.0 267 254 249 248 247 246 245 244 243 151 STE20/SPS1-related proline-alanine-rich protein kinase
STE STK39 STK39_MOUSE 5D9HB Q9Z1W9 65 364 556.0 ATP:501 ATPlike Inactive DFGin 5.6862 16.5571 BLBtrans -110.27, 163.88 60.61, 61.2 -112.96, 152.81 160.68, 82.77 89.89, -127.48 out-out out 13.7117 Saltbr-out 13.1009 HRD-in -78.11, -50.69 74.23, -12.16 out-out-out SNCooo out-out ActLoopNT-out 7.9127 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 140.15 APE8-dihe-in -87.12, 142.28 APE8-rot-out 185.38 APE67-dihe-in -78.59, -19.5 -91.99, 27.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 28.7069 None None None XRAY 3.1 0.24 0.269 B 348.0 293.0 7 33 26 7 [[75, 349]] 1.0 5d9h Mus musculus STE_STK39_MOUSE STE 1.3e-90 309.2 1.0 257.0 257.0 221 222 223 225 227 104 121 125 201 203 202 204.0 267 254 249 248 247 246 245 244 243 151 STE20/SPS1-related proline-alanine-rich protein kinase
TKL RIPK4 RIPK4_MOUSE 5WNIA Q9ERK0 9 288 786.0 ATP:403 ATPlike Inactive DFGin 5.0309 14.7639 BLAminus -137.21, -171.18 63.31, 81.36 -101.4, 15.3 283.28, 78.59 -51.45, -36.22 in-in in 8.6455 Saltbr-in 2.4821 HRD-in -76.93, -54.51 67.9, 5.7 in-in-out SNCiio in-out ActLoopNT-in 3.2042 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 127.03 APE9-dihe-na -72.21, -45.63 APE8-dihe-out -54.13, -30.5 APE8-rot-out 51.09 APE67-dihe-in -56.9, -38.97 -54.07, -35.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.4582 APE9-dist-out 11.3874 D143N None None XRAY 2.65 0.204 0.248 A 342.0 263.0 17 31 18 13 [[19, 285]] 1.0 5wni Mus musculus TKL_RIPK4_MOUSE TKL 1.4e-74 257.0 4.0 266.0 263.0 160 161 162 164 166 51 69 73 140 142 141 143.0 205 191 186 185 184 183 182 181 180 97 Receptor-interacting serine/threonine-protein kinase 4
CAMK PHKG1 PHKG1_RABIT 2PHKA P00518 15 291 387.0 ATP:60381 ATPlike Active DFGin 6.3547 14.9309 BLAminus -137.29, -164.32 48.12, 82.5 -104.58, 35.29 286.95, 71.57 -66.18, -30.51 in-in in 9.2235 Saltbr-in 2.8672 HRD-in -75.14, -51.03 75.46, 17.9 in-in-in SNCiii in-in ActLoopNT-in 2.8851 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.02, 157.52 APE9-dihe-na 142.39, -153.7 APE8-dihe-in -119.73, 129.29 APE8-rot-in 312.14 APE67-dihe-in -75.97, -3.06 -46.22, -51.97 APE12-dist-in 9.1878 APE11-dist-in 12.0375 APE10-dist-in 6.5648 APE9-dist-in 4.1866 None None None XRAY 2.6 0.253 0.3 A 277.0 277.0 0 27 27 0 [[20, 288]] 1.0 2phk Oryctolagus cuniculus CAMK_PHKG1_RABIT CAMK 3e-86 294.8 1.0 256.0 256.0 167 168 169 171 173 49 74 78 147 149 148 150.0 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK PHKG1 PHKG1_RABIT 1QL6A P00518 12 292 387.0 ATP:60301 ATPlike Active DFGin 6.3666 14.6137 BLAminus -136.63, -170.42 53.21, 74.77 -97.04, 26.39 287.52, 75.09 -70.06, -14.72 in-in in 9.2046 Saltbr-in 3.0996 HRD-in -59.97, -49.78 67.92, 7.3 in-in-in SNCiii in-in ActLoopNT-in 2.8963 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.76, 155.97 APE9-dihe-na 109.55, 169.96 APE8-dihe-in -76.43, 127.92 APE8-rot-in 308.32 APE67-dihe-in -67.24, -23.63 -51.61, -34.62 APE12-dist-in 9.2587 APE11-dist-in 11.4451 APE10-dist-in 6.1099 APE9-dist-in 4.369 E183S None None XRAY 2.4 0.24 0.33 A 298.0 281.0 0 27 27 0 [[20, 288]] 1.0 1ql6 Oryctolagus cuniculus CAMK_PHKG1_RABIT CAMK 5.1e-86 294.1 1.0 256.0 256.0 167 168 169 171 173 49 74 78 147 149 148 150.0 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK PHKG1 PHKG1_RABIT 1PHKA P00518 16 292 387.0 ATP:60381 ATPlike Active DFGin 6.147 14.3364 BLAminus -126.89, -173.45 56.12, 79.25 -99.09, 29.57 290.92, 76.23 -67.63, -19.58 in-in in 8.9934 Saltbr-in 2.8252 HRD-in -77.33, -46.36 68.03, 5.86 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.41, 147.14 APE9-dihe-na 116.4, 168.87 APE8-dihe-in -72.55, 120.48 APE8-rot-in 295.05 APE67-dihe-in -62.26, -27.58 -41.92, -42.38 APE12-dist-in 8.8358 APE11-dist-in 11.4296 APE10-dist-in 6.1569 APE9-dist-in 4.492 None None None XRAY 2.2 0.21 0.288 A 298.0 277.0 0 27 27 0 [[20, 288]] 1.0 1phk Oryctolagus cuniculus CAMK_PHKG1_RABIT CAMK 4e-86 294.4 1.0 256.0 256.0 167 168 169 171 173 49 74 78 147 149 148 150.0 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
STE MAP2K1 MP2K1_RABIT 2Y4IC P29678 37 381 393.0 ATP:1382 ATPlike Inactive DFGin 6.1966 13.7557 BLBplus -151.54, -176.33 53.75, 29.39 -91.07, 130.43 56.39, 97.48 -61.44, 113.3 out-out out 16.1319 Saltbr-out 15.7942 HRD-in -53.6, -47.94 74.29, -22.1 out-out-out SNCooo out-out ActLoopNT-out 9.9 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -108.6, -60.21 APE9-dihe-na 86.78, -165.04 APE8-dihe-out -116.15, -0.77 APE8-rot-out 172.84 APE67-dihe-out -107.13, 167.3 -126.53, 122.47 APE12-dist-out 16.2589 APE11-dist-out 19.1611 APE10-dist-out 21.2782 APE9-dist-out 14.8665 None None None XRAY 3.46 0.233 0.293 C 395.0 313.0 32 26 26 0 [[68, 361]] 1.0 2y4i Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.5e-97 331.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
OTHER FLS2 FLS2_ORYSJ 8JUPA Q0JA29 861 1176 1183.0 ATP:60401 ATPlike Inactive DFGin 6.1593 14.1808 BLAminus -129.46, 178.87 65.25, 87.62 -100.45, 24.31 288.53, 78.58 -69.31, -13.11 in-in in 7.7583 Saltbr-in 2.6348 HRD-in -73.88, -45.26 75.34, -0.8 in-in-out SNCiio in-out ActLoopNT-in 2.7582 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -97.88, 176.26 APE9-dihe-na 47.04, -123.5 APE8-dihe-out -91.29, -3.22 APE8-rot-out 60.74 APE67-dihe-in -61.44, -18.49 -67.89, -32.09 APE12-dist-out 23.4332 APE11-dist-out 18.4808 APE10-dist-out 19.3689 APE9-dist-out 12.3466 None None MSE903,MSE959,MSE1037,MSE1066,MSE1073,MSE1090,MSE1134,MSE1166,MSE1176 XRAY 1.98 0.202 0.221 A 327.0 286.0 30 39 23 16 [[874, 1175]] 1.0 8jup Oryza sativa OTHER_FLS2_ORYSJ TKL 3.2e-44 157.5 4.0 265.0 262.0 1030 1031 1032 1034 1036 908 926 930 1010 1012 1011 1013.0 1081 1069 1064 1063 1062 1061 1060 1059 1058 957 LRR receptor-like serine/threonine-protein kinase FLS2
CMGC CK1 Q8IIR9_PLAF7 5XVUA Q8IIR9 12 332 335.0 ATP:403 ATPlike Inactive DFGin 7.3209 16.711 BLAminus -110.04, -170.26 56.43, 69.12 -91.86, 16.9 294.29, 86.98 -66.48, -34.8 in-in in 9.4524 Saltbr-in 2.8021 HRD-in -73.92, -41.02 61.9, 9.67 in-in-out SNCiio in-out ActLoopNT-in 2.9655 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.27, 163.04 APE9-dihe-na 66.36, 159.74 APE8-dihe-in -64.44, 138.76 APE8-rot-out 161.92 APE67-dihe-in -63.63, -26.0 -45.45, -45.73 APE12-dist-in 12.799 APE11-dist-in 10.7805 APE10-dist-in 6.0039 APE9-dist-in 3.652 None None None XRAY 3.0 0.174 0.216 A 332.0 321.0 0 27 27 0 [[43, 328]] 1.0 5xvu Plasmodium falciparum CMGC_CK1_PLAF7 CMGC 2.9e-67 232.9 1.0 301.0 301.0 178 179 180 182 184 72 85 89 157 159 158 160.0 218 205 200 199 198 197 196 195 194 118 non-specific serine/threonine protein kinase
CMGC CK1 Q8IIR9_PLAF7 5XVUB Q8IIR9 12 332 335.0 ATP:404 ATPlike Inactive DFGin 7.401 16.6742 BLAminus -109.75, -170.19 56.85, 69.23 -92.76, 17.97 295.03, 87.19 -67.17, -35.33 in-in in 9.3006 Saltbr-in 2.7928 HRD-in -71.07, -41.36 62.96, 8.73 in-in-out SNCiio in-out ActLoopNT-in 2.8641 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -122.62, -85.86 APE9-dihe-na -52.99, 173.24 APE8-dihe-in -65.9, 138.47 APE8-rot-out 161.08 APE67-dihe-in -63.67, -25.37 -44.18, -46.51 APE12-dist-in 12.7437 APE11-dist-in 10.6152 APE10-dist-in 5.9411 APE9-dist-in 3.5974 None None None XRAY 3.0 0.174 0.216 B 332.0 321.0 0 27 27 0 [[43, 328]] 1.0 5xvu Plasmodium falciparum CMGC_CK1_PLAF7 CMGC 2.9e-67 232.9 1.0 301.0 301.0 178 179 180 182 184 72 85 89 157 159 158 160.0 218 205 200 199 198 197 196 195 194 118 non-specific serine/threonine protein kinase
CMGC CK1 Q8IIR9_PLAF7 5XVUC Q8IIR9 12 332 335.0 ATP:405 ATPlike Inactive DFGin 7.4919 16.7422 BLAminus -109.76, -170.14 57.17, 68.62 -92.1, 18.51 294.14, 87.94 -67.81, -35.21 in-in in 9.4558 Saltbr-in 2.8076 HRD-in -70.49, -40.6 62.72, 9.24 in-in-out SNCiio in-out ActLoopNT-in 2.9425 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -116.02, -79.39 APE9-dihe-na -60.1, 172.38 APE8-dihe-in -65.34, 140.21 APE8-rot-out 160.23 APE67-dihe-in -64.3, -24.41 -46.46, -45.68 APE12-dist-in 12.7405 APE11-dist-in 10.6424 APE10-dist-in 5.8451 APE9-dist-in 3.6324 None None None XRAY 3.0 0.174 0.216 C 332.0 321.0 0 27 27 0 [[43, 328]] 1.0 5xvu Plasmodium falciparum CMGC_CK1_PLAF7 CMGC 2.9e-67 232.9 1.0 301.0 301.0 178 179 180 182 184 72 85 89 157 159 158 160.0 218 205 200 199 198 197 196 195 194 118 non-specific serine/threonine protein kinase
CMGC MAPK1 MK01_RAT 4GT3A P63086 9 356 358.0 ATP:402 ATPlike Inactive DFGin 6.7027 16.1444 BLAminus -134.54, -176.44 66.94, 76.71 -104.84, 22.9 282.81, 76.31 -55.64, -34.0 in-none in 9.8171 Saltbr-none 999.0 HRD-in -69.89, -50.79 79.79, -14.59 none-in-out SNCnio in-out ActLoopNT-in 2.7761 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -105.46, -44.03 APE9-dihe-na -70.04, 169.29 APE8-dihe-in -70.71, 123.51 APE8-rot-in 309.48 APE67-dihe-in -61.98, -17.54 -56.41, -47.97 APE12-dist-out 14.2886 APE11-dist-in 11.0026 APE10-dist-in 6.7399 APE9-dist-in 4.4218 None None CME159 XRAY 1.68 0.168 0.2 A 364.0 348.0 0 31 31 0 [[23, 311]] 1.0 4gt3 Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.4e-85 293.1 1.0 301.0 301.0 164 165 166 168 170 52 69 73 144 146 145 147.0 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 1GOLA P63086 2 358 358.0 ATP:581 ATPlike Inactive DFGin 6.8401 16.5086 BLAminus -138.32, 175.35 71.89, 79.82 -106.15, 29.68 287.28, 71.38 -70.4, -19.75 out-none out 10.4077 Saltbr-none 999.0 HRD-in -68.54, -52.86 75.92, 1.19 none-in-out SNCnio in-out ActLoopNT-in 2.8991 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -103.2, -24.36 APE9-dihe-na -62.06, 164.48 APE8-dihe-in -61.17, 119.13 APE8-rot-in 302.33 APE67-dihe-in -53.15, -25.45 -41.46, -58.53 APE12-dist-out 14.3386 APE11-dist-in 11.2075 APE10-dist-in 7.401 APE9-dist-in 4.2815 K52R None None XRAY 2.8 999.0 999.0 A 364.0 357.0 0 31 31 0 [[23, 311]] 1.0 1gol Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.4e-84 289.8 1.0 301.0 301.0 164 165 166 168 170 52 69 73 144 146 145 147.0 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
STE TAOK2 TAOK2_RAT 1U5RA Q9JLS3 12 320 1235.0 ATP:411 ATPlike Active DFGin 6.9896 14.2399 BLAminus -128.27, -174.18 56.24, 80.49 -99.99, 21.83 293.09, 83.93 -60.11, -26.41 in-in in 8.687 Saltbr-in 2.8872 HRD-in -75.95, -53.43 76.2, -2.14 in-in-in SNCiii in-in ActLoopNT-in 2.7667 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.19, 153.0 APE9-dihe-na 135.08, -166.49 APE8-dihe-in -116.65, 119.51 APE8-rot-in 301.53 APE67-dihe-in -56.87, -24.9 -27.41, -63.55 APE12-dist-in 8.4456 APE11-dist-in 11.3907 APE10-dist-in 5.5071 APE9-dist-in 3.2793 None SEP181 SEP181 XRAY 2.1 0.211 0.244 A 348.0 309.0 0 24 24 0 [[28, 281]] 1.0 1u5r Rattus norvegicus STE_TAOK2_RAT STE 1.4e-89 305.8 2.0 257.0 256.0 168 169 170 172 174 57 76 80 148 150 149 151.0 207 192 187 186 185 184 183 182 181 106 Serine/threonine-protein kinase TAO2
STE TAOK2 TAOK2_RAT 1U5RB Q9JLS3 12 320 1235.0 ATP:412 ATPlike Active DFGin 6.7633 13.8958 BLAminus -129.03, -178.62 56.08, 82.23 -96.99, 22.88 295.53, 83.61 -63.46, -23.11 in-in in 8.7722 Saltbr-in 2.6231 HRD-in -71.62, -50.86 71.95, 2.83 in-in-in SNCiii in-in ActLoopNT-in 2.7763 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.4, 155.39 APE9-dihe-na 130.83, -165.29 APE8-dihe-in -116.7, 116.24 APE8-rot-in 302.47 APE67-dihe-in -61.68, -22.51 -24.84, -62.59 APE12-dist-in 8.9051 APE11-dist-in 11.0198 APE10-dist-in 5.2819 APE9-dist-in 3.304 None SEP181 SEP181 XRAY 2.1 0.211 0.244 B 348.0 309.0 0 24 24 0 [[28, 281]] 1.0 1u5r Rattus norvegicus STE_TAOK2_RAT STE 1.4e-89 305.8 2.0 257.0 256.0 168 169 170 172 174 57 76 80 148 150 149 151.0 207 192 187 186 185 184 183 182 181 106 Serine/threonine-protein kinase TAO2
CMGC CKA1 CSK21_YEAST 4FI1A P15790 1 371 372.0 ATP:403 ATPlike Inactive None 23.9376 16.2374 None -116.2, -173.62 60.19, 79.18 -100.6, 15.4 291.83, 86.61 -72.61, -17.46 out-na out 37.8579 Saltbr-na 999.0 HRD-in -72.28, -48.07 67.04, 8.76 na-in-out SNCaio in-out ActLoopNT-in 2.9261 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.66, 175.92 APE9-dihe-na 60.75, -165.68 APE8-dihe-in -116.66, 152.71 APE8-rot-out 187.49 APE67-dihe-in -64.93, -21.65 -39.27, -55.57 APE12-dist-in 12.7411 APE11-dist-in 10.9227 APE10-dist-in 6.0716 APE9-dist-in 3.4192 None None None XRAY 2.09 0.206 0.243 A 374.0 371.0 0 27 27 0 [[100, 363]] 1.0 4fi1 Saccharomyces cerevisiae CMGC_CKA1_YEAST CMGC 0.0001 199.7 1.0 55.0 321.0 213 214 215 217 219 69 114 118 192 194 193 195.0 253 240 235 234 233 232 231 230 229 153 Casein kinase II subunit alpha
CMGC CKA1 CSK21_YEAST 4MWHA P15790 1 371 372.0 ATP:401 ATPlike Inactive None 23.9776 16.2185 None -116.51, -173.69 61.16, 78.03 -99.81, 14.04 291.24, 86.36 -72.33, -17.88 out-na out 37.853 Saltbr-na 999.0 HRD-in -70.43, -48.46 67.2, 9.69 na-in-out SNCaio in-out ActLoopNT-in 2.9601 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -135.3, 175.12 APE9-dihe-na 58.95, -171.53 APE8-dihe-in -112.48, 153.51 APE8-rot-out 184.1 APE67-dihe-in -66.06, -21.26 -39.33, -54.63 APE12-dist-in 12.7311 APE11-dist-in 10.9232 APE10-dist-in 6.0707 APE9-dist-in 3.4788 None None None XRAY 2.09 0.199 0.241 A 374.0 371.0 0 27 27 0 [[100, 363]] 1.0 4mwh Saccharomyces cerevisiae CMGC_CKA1_YEAST CMGC 0.0001 199.7 1.0 55.0 321.0 213 214 215 217 219 69 114 118 192 194 193 195.0 253 240 235 234 233 232 231 230 229 153 Casein kinase II subunit alpha
CMGC SKY1 SKY1_YEAST 1Q97A Q03656 144 737 742.0 ATP:60485 ATPlike Active DFGin 5.605 12.6475 BLAminus -113.61, -176.06 45.65, 81.54 -92.49, 25.33 294.84, 21.0 -61.4, -14.56 in-in in 8.92 Saltbr-in 2.9102 HRD-in -73.18, -42.39 69.86, -2.96 in-in-in SNCiii in-in ActLoopNT-in 2.9854 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.18, 168.88 APE9-dihe-na 68.54, 141.02 APE8-dihe-in -74.6, 131.99 APE8-rot-in 300.34 APE67-dihe-in -58.79, -28.16 -13.13, -73.4 APE12-dist-in 12.5859 APE11-dist-in 10.4977 APE10-dist-in 7.6309 APE9-dist-in 3.163 None None None XRAY 2.3 0.215 0.264 A 373.0 351.0 11 25 25 0 [[158, 706]] 1.0 1q97 Saccharomyces cerevisiae CMGC_SKY1_YEAST CMGC 8.8e-100 339.7 1.0 301.0 301.0 549 550 551 553 555 187 202 206 291 293 292 294.0 586 574 569 568 567 566 565 564 563 247 Serine/threonine-protein kinase SKY1
OTHER GCN2-2 GCN2_YEAST 1ZYDA P15442 594 996 1659.0 ATP:60303 ATPlike Inactive DFGin 6.4103 14.1059 BLBminus -140.51, -168.68 57.3, 45.16 -50.27, 137.38 287.66, 72.18 -82.02, 105.81 out-out out 12.8009 Saltbr-out 11.5022 HRD-in -64.16, -46.0 70.86, 0.79 out-out-out SNCooo out-out ActLoopNT-out 8.8327 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 87.46 APE9-dihe-na 82.34, -63.68 APE8-dihe-out -63.29, -19.6 APE8-rot-out 172.58 APE67-dihe-in -77.43, -0.66 -78.79, -26.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.861 APE9-dist-out 12.0935 None None None XRAY 2.75 0.208 0.27 A 303.0 268.0 32 42 16 26 [[292, 527], [599, 981]] 2.0 1zyd Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 7.9e-45 164.1 2.0 254.0 253.0 852 853 854 856 858 628 643 647 832 834 833 835.0 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
OTHER GCN2-2 GCN2_YEAST 1ZYDB P15442 594 983 1659.0 ATP:60304 ATPlike Inactive DFGin 6.5576 14.1835 BLBminus -148.24, -169.36 49.61, 62.39 -64.34, 151.67 288.08, 61.76 -84.72, 102.57 out-out out 12.6474 Saltbr-out 11.1618 HRD-in -64.07, -43.6 67.43, 4.77 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 127.88 APE9-dihe-na -94.37, -36.47 APE8-dihe-out -54.75, -25.46 APE8-rot-in 302.91 APE67-dihe-in -57.91, -12.21 -57.71, -47.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.7885 APE9-dist-out 11.857 None None None XRAY 2.75 0.208 0.27 B 303.0 251.0 36 42 15 27 [[292, 527], [599, 981]] 2.0 1zyd Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 7.9e-45 164.1 2.0 254.0 253.0 852 853 854 856 858 628 643 647 832 834 833 835.0 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
CK1 CKI1 CKI1_SCHPO 1CSNA P40233 6 298 446.0 ATP:299 ATPlike Active DFGin 6.4218 13.7895 BLAminus -124.8, 177.22 63.85, 88.12 -109.85, 36.77 298.25, 97.14 -71.61, -21.33 in-in in 8.0396 Saltbr-in 3.0859 HRD-in -68.74, -48.02 63.6, 9.84 in-in-in SNCiii in-in ActLoopNT-in 2.8146 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -97.61, -90.82 APE9-dihe-na -65.25, -165.09 APE8-dihe-in -55.42, 111.92 APE8-rot-in 313.89 APE67-dihe-in -55.02, -31.3 -55.98, -42.83 APE12-dist-in 12.7405 APE11-dist-in 13.0074 APE10-dist-in 7.1601 APE9-dist-in 4.7937 None None None XRAY 2.0 0.207 999.0 A 298.0 293.0 0 35 35 0 [[12, 280]] 1.0 1csn Schizosaccharomyces pombe CK1_CKI1_SCHPO CK1 8e-95 323.1 1.0 261.0 261.0 153 154 155 157 159 41 55 59 128 130 129 131.0 200 188 183 182 181 180 179 178 177 86 Casein kinase I homolog 1

Ligand: ATP

Total number of chains: 64
Active chains: 29
Total number of genes: 21
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 43 67.2% 1RDQE
DFGin None 12 18.8% 4CYIA
DFGin BLBminus 3 4.7% 7Z9TBBB
DFGin BLBplus 2 3.1% 8HOAA
DFGin BLBtrans 2 3.1% 5D9HB
None None 2 3.1% 4FI1A

Hover over column headers for tooltip help.

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ
DFG-Asp
φ,ψ
DFG-Phe
φ,ψ
DFG-Phe
χ1,χ2
DFG-Gly
φ,ψ
ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL BRI1 BRI1_ARATH 5LPYA O22476 867 1160 1196.0 ATP:1200 ATPlike Active DFGin 5.1746 15.2032 BLAminus -134.16, 179.9 60.37, 82.56 -100.0, 17.51 285.92, 71.71 -57.07, -20.27 in-in in 8.8923 Saltbr-in 3.1518 HRD-in -70.7, -49.88 77.86, -1.82 in-in-in SNCiii in-in ActLoopNT-in 2.9078 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.47, 151.76 APE9-dihe-na 140.48, 176.99 APE8-dihe-in -121.99, 138.13 APE8-rot-in 307.91 APE67-dihe-inflip 92.03, -10.16 -52.79, 133.04 APE12-dist-in 9.6093 APE11-dist-in 11.5236 APE10-dist-in 5.7212 APE9-dist-in 3.8848 T872A TPO1039,SEP1042,SEP1044,SEP1060 TPO1039,SEP1042,SEP1044,SEP1060 XRAY 2.3 0.203 0.248 A 296.0 286.0 8 30 30 0 [[882, 1157]] 1.0 5lpy Arabidopsis thaliana TKL_BRI1_ARATH TKL 2e-63 220.4 4.0 266.0 263.0 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009.0 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL FERONIA FERON_ARATH 7XDVA Q9SCZ4 521 815 895.0 ATP:60401 ATPlike None DFGin 6.6994 15.5725 BLAminus -134.27, 177.47 68.35, 79.21 -98.58, 11.5 282.56, 76.24 -59.84, -20.83 in-none in 8.7227 Saltbr-none 999.0 HRD-in -67.4, -48.26 73.32, 1.35 none-in-none SNCnin in-none ActLoopNT-in 2.9051 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 147.64 APE8-rot-in 320.48 APE67-dihe-in -72.12, 2.13 -58.53, -58.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.97 0.172 0.213 A 313.0 283.0 12 30 18 12 [[535, 809]] 1.0 7xdv Arabidopsis thaliana TKL_FERONIA_ARATH TKL 8.2e-57 198.7 3.0 266.0 264.0 678 679 680 682 684 565 581 585 658 660 659 661.0 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
TKL FERONIA FERON_ARATH 7XDVB Q9SCZ4 522 816 895.0 ATP:60401 ATPlike None DFGin 6.6762 15.7003 BLAminus -133.75, 179.29 66.82, 78.34 -97.78, 11.62 279.93, 76.8 -60.95, -21.55 in-none in 8.917 Saltbr-none 999.0 HRD-in -65.85, -46.61 72.82, 0.74 none-in-none SNCnin in-none ActLoopNT-in 2.8555 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 149.11 APE8-rot-in 319.48 APE67-dihe-in -72.05, 2.55 -59.63, -58.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.97 0.172 0.213 B 313.0 283.0 12 30 18 12 [[535, 809]] 1.0 7xdv Arabidopsis thaliana TKL_FERONIA_ARATH TKL 8.2e-57 198.7 3.0 266.0 264.0 678 679 680 682 684 565 581 585 658 660 659 661.0 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
OTHER LANKC A0A6H0TJ16_BACTU 8SAMA A0A6H0TJ16 1 862 872.0 ATP:60902 ATPlike None DFGin 6.6401 14.881 BLAminus -119.81, 176.45 65.16, 86.81 -107.13, 32.95 280.75, 71.48 -74.73, -19.84 in-in in 7.4098 Saltbr-in 2.7754 HRD-na- -76.54, -26.64 101.12, -25.28 in-in-none SNCiin in-none ActLoopNT-in 2.7503 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.15 0.205 0.251 A 904.0 845.0 0 -381 -381 0 [[228, 410]] 1.0 8sam Bacillus thuringiensis serovar andalousiensis OTHER_LANKC_BACTU CAMK 1.4e-13 57.3 1.0 164.0 164.0 381 382 383 385 387 257 279 283 361 363 362 364.0 0 0 0 0 0 0 0 0 0 310 Class III lanthionine synthetase LanKC
OTHER LANKC A0A6H0TJ16_BACTU 8SAMB A0A6H0TJ16 1 862 872.0 ATP:60901 ATPlike Inactive DFGin 6.7493 15.0087 BLAminus -116.86, 172.09 66.52, 88.25 -108.59, 34.42 278.94, 73.78 -73.89, -19.99 in-out in 7.4791 Saltbr-out 3.8646 HRD-na- -85.28, 118.03 -78.23, 6.03 out-in-none SNCoin in-none ActLoopNT-in 2.7645 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.15 0.205 0.251 B 904.0 844.0 0 -381 -381 0 [[228, 410]] 1.0 8sam Bacillus thuringiensis serovar andalousiensis OTHER_LANKC_BACTU CAMK 1.4e-13 57.3 1.0 164.0 164.0 381 382 383 385 387 257 279 283 361 363 362 364.0 0 0 0 0 0 0 0 0 0 310 Class III lanthionine synthetase LanKC
AGC GRK1 GRK1_BOVIN 3T8OA P28327 30 532 561.0 ATP:562 ATPlike Active DFGin 6.784 13.6519 BLAminus -147.61, 176.5 66.51, 86.5 -106.39, 20.07 278.45, 121.96 -78.51, -8.51 in-in in 9.1312 Saltbr-in 2.9462 HRD-in -72.08, -59.57 74.93, 15.13 in-in-in SNCiii in-in ActLoopNT-in 3.0341 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.6, 145.4 APE9-dihe-na 140.82, -165.62 APE8-dihe-in -114.33, 123.31 APE8-rot-in 302.45 APE67-dihe-inflip 90.49, -9.25 -48.36, 136.06 APE12-dist-in 10.4193 APE11-dist-in 11.6453 APE10-dist-in 5.7954 APE9-dist-in 4.2758 L166K None None XRAY 2.5 0.209 0.245 A 543.0 493.0 0 28 28 0 [[187, 452]] 1.0 3t8o Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4.0 260.0 257.0 331 332 333 335 337 216 235 239 311 313 312 314.0 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C4WA P28327 31 533 561.0 ATP:562 ATPlike Active DFGin 6.5874 13.3137 BLAminus -157.51, 175.0 67.79, 80.23 -106.97, 21.1 277.77, 138.55 -72.95, -18.52 in-in in 8.6705 Saltbr-in 2.6589 HRD-in -67.86, -51.97 60.46, 12.85 in-in-in SNCiii in-in ActLoopNT-in 2.8974 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.73, 153.77 APE9-dihe-na 125.45, -175.95 APE8-dihe-in -101.44, 127.92 APE8-rot-in 301.93 APE67-dihe-inflip 97.46, -21.92 -46.81, 133.28 APE12-dist-in 10.0067 APE11-dist-in 11.2485 APE10-dist-in 5.5344 APE9-dist-in 3.5083 None TPO8 TPO8 XRAY 2.7 0.192 999.0 A 543.0 494.0 0 28 28 0 [[187, 452]] 1.0 3c4w Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4.0 260.0 257.0 331 332 333 335 337 216 235 239 311 313 312 314.0 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C4WB P28327 5 533 561.0 ATP:562 ATPlike Active DFGin 5.9629 13.1113 BLAminus -155.04, 178.49 64.64, 79.84 -103.28, 19.03 277.57, 109.21 -72.3, -19.68 in-in in 8.548 Saltbr-in 2.84 HRD-in -67.79, -54.67 64.69, 11.83 in-in-in SNCiii in-in ActLoopNT-in 2.9583 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.45, 154.48 APE9-dihe-na 126.08, -175.35 APE8-dihe-in -101.18, 126.91 APE8-rot-in 300.91 APE67-dihe-inflip 94.23, -17.08 -47.18, 130.86 APE12-dist-in 10.1029 APE11-dist-in 11.2538 APE10-dist-in 5.5445 APE9-dist-in 3.5342 None TPO8 TPO8 XRAY 2.7 0.192 999.0 B 543.0 519.0 0 28 28 0 [[187, 452]] 1.0 3c4w Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4.0 260.0 257.0 331 332 333 335 337 216 235 239 311 313 312 314.0 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C4XA P28327 30 533 561.0 ATP:562 ATPlike Active DFGin 6.3918 13.2944 BLAminus -153.36, -178.73 56.38, 83.66 -101.23, 19.01 282.86, 141.85 -58.01, -33.04 in-in in 8.6227 Saltbr-in 2.8246 HRD-in -65.41, -52.58 62.44, 13.36 in-in-in SNCiii in-in ActLoopNT-in 2.9597 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -170.48, 144.22 APE9-dihe-na 128.55, -174.69 APE8-dihe-in -103.7, 129.98 APE8-rot-in 314.1 APE67-dihe-inflip 101.04, -22.84 -50.28, 132.61 APE12-dist-in 10.283 APE11-dist-in 11.2374 APE10-dist-in 5.7264 APE9-dist-in 3.8266 None None None XRAY 2.9 0.193 999.0 A 543.0 496.0 0 28 28 0 [[187, 452]] 1.0 3c4x Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4.0 260.0 257.0 331 332 333 335 337 216 235 239 311 313 312 314.0 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C4XB P28327 31 533 561.0 ATP:562 ATPlike Active DFGin 5.9031 13.063 BLAminus -149.62, 174.69 57.3, 76.73 -95.24, 8.98 282.05, 96.12 -51.11, -35.54 in-in in 8.6415 Saltbr-in 2.6755 HRD-in -62.32, -48.48 63.55, 4.44 in-in-in SNCiii in-in ActLoopNT-in 3.0432 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.42, 143.72 APE9-dihe-na 129.46, -175.16 APE8-dihe-in -98.28, 125.3 APE8-rot-in 312.69 APE67-dihe-inflip 98.15, -18.1 -45.11, 129.51 APE12-dist-in 10.2012 APE11-dist-in 11.2468 APE10-dist-in 5.6099 APE9-dist-in 3.6392 None None None XRAY 2.9 0.193 999.0 B 543.0 475.0 0 28 28 0 [[187, 452]] 1.0 3c4x Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4.0 260.0 257.0 331 332 333 335 337 216 235 239 311 313 312 314.0 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC PRKACA KAPCA_BOVIN 9DW9G P00517 13 351 351.0 ATP:401 ATPlike Active DFGin 6.5695 15.1264 BLAminus -133.9, -169.96 59.46, 64.31 -83.85, 33.99 275.29, 73.58 -66.33, -24.36 in-in in 9.4988 Saltbr-in 3.2167 HRD-in -92.3, -53.34 68.25, 14.14 in-in-in SNCiii in-in ActLoopNT-in 3.0799 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.91, 151.76 APE9-dihe-na 126.66, -174.62 APE8-dihe-in -92.84, 130.69 APE8-rot-in 299.41 APE67-dihe-in -68.55, -23.13 -58.33, -34.44 APE12-dist-in 8.7033 APE11-dist-in 11.5632 APE10-dist-in 6.1702 APE9-dist-in 4.5677 None TPO198 TPO198 EM 2.8 999.0 999.0 G 351.0 328.0 0 25 25 0 [[44, 298]] 1.0 9dw9 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1Q24A P00517 15 351 351.0 ATP:60400 ATPlike Active DFGin 5.9832 14.3195 BLAminus -113.95, 178.0 66.86, 85.15 -103.99, 32.82 274.7, 64.8 -65.44, -25.66 in-in in 8.779 Saltbr-in 2.742 HRD-in -93.22, -55.61 73.46, 14.95 in-in-in SNCiii in-in ActLoopNT-in 3.0897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.66, 162.77 APE9-dihe-na 133.15, -143.39 APE8-dihe-in -135.22, 127.61 APE8-rot-in 301.89 APE67-dihe-in -67.43, -30.61 -42.63, -46.05 APE12-dist-in 8.0357 APE11-dist-in 11.4473 APE10-dist-in 6.0235 APE9-dist-in 3.486 V124A,L174M TPO198,SEP339 TPO198,SEP339 XRAY 2.6 0.202 0.25 A 350.0 337.0 0 25 25 0 [[44, 298]] 1.0 1q24 Bos taurus AGC_PRKACA_BOVIN AGC 4.8e-94 320.4 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
OTHER PAN3 PAN3_CHATD 4CYIA G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.5855 12.8524 None -92.38, -13.16 -130.85, 61.75 -94.99, 144.51 286.93, 999.0 79.52, -4.52 out-na out 13.591 Saltbr-na 999.0 HRD-out -83.98, 84.54 -50.92, -35.91 na-out-na SNCaoa out-na ActLoopNT-out 7.062 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -80.88, -42.8 APE9-dihe-na -64.32, -40.93 APE8-dihe-na -99.24, 17.32 APE8-rot-na 300.48 APE67-dihe-na -73.05, -48.17 -58.31, -53.55 APE12-dist-na 4.897 APE11-dist-na 5.5425 APE10-dist-na 5.1047 APE9-dist-na 11.5716 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 A 438.0 405.0 0 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIB G0S0Y3 213 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.6162 12.9181 None -91.62, -15.83 -130.65, 63.54 -94.89, 145.11 286.33, 999.0 77.48, -4.88 out-na out 13.5804 Saltbr-na 999.0 HRD-out -84.8, 85.11 -51.08, -35.56 na-out-na SNCaoa out-na ActLoopNT-out 7.1748 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -82.17, -41.93 APE9-dihe-na -64.26, -40.58 APE8-dihe-na -98.12, 16.28 APE8-rot-na 298.69 APE67-dihe-na 80.12, -45.62 -60.06, 122.74 APE12-dist-na 4.8933 APE11-dist-na 5.4782 APE10-dist-na 5.0793 APE9-dist-na 11.8701 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 B 438.0 406.0 8 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIC G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.4924 12.6474 None -89.83, -13.71 -129.71, 95.5 -125.66, 144.13 285.48, 999.0 76.65, -4.79 out-na out 13.5683 Saltbr-na 999.0 HRD-out -84.9, 84.38 -51.27, -35.99 na-out-na SNCaoa out-na ActLoopNT-out 7.0361 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.46, -42.97 APE9-dihe-na -65.29, -40.87 APE8-dihe-na -98.03, 18.1 APE8-rot-na 300.5 APE67-dihe-na -80.64, -42.62 -57.0, -52.24 APE12-dist-na 4.8695 APE11-dist-na 5.4118 APE10-dist-na 5.1039 APE9-dist-na 11.7021 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 C 438.0 397.0 8 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYID G0S0Y3 214 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.5811 12.83 None -92.56, -14.61 -129.54, 61.33 -91.03, 145.16 286.17, 999.0 78.34, -3.87 out-na out 13.6323 Saltbr-na 999.0 HRD-out -84.73, 84.5 -51.45, -36.17 na-out-na SNCaoa out-na ActLoopNT-out 6.9797 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -82.5, -42.63 APE9-dihe-na -63.84, -39.93 APE8-dihe-na -97.69, 15.27 APE8-rot-na 300.06 APE67-dihe-na 82.88, -51.63 -61.5, 124.95 APE12-dist-na 4.8492 APE11-dist-na 5.59 APE10-dist-na 5.161 APE9-dist-na 11.6129 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 D 438.0 407.0 8 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIE G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.538 12.7667 None -90.87, -14.73 -130.14, 65.48 -95.4, 143.11 286.9, 999.0 77.19, -4.14 out-na out 13.9331 Saltbr-na 999.0 HRD-out -83.54, 85.23 -50.62, -36.04 na-out-na SNCaoa out-na ActLoopNT-out 6.9622 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.29, -42.51 APE9-dihe-na -65.13, -42.05 APE8-dihe-na -99.46, 17.91 APE8-rot-na 300.53 APE67-dihe-na -82.88, -16.1 -58.82, -52.89 APE12-dist-na 4.8671 APE11-dist-na 5.5056 APE10-dist-na 4.9898 APE9-dist-na 11.6524 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 E 438.0 394.0 10 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIF G0S0Y3 213 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.6574 12.9278 None -90.71, -14.62 -131.6, 64.5 -94.2, 145.33 287.42, 999.0 78.97, -5.05 out-na out 13.6193 Saltbr-na 999.0 HRD-out -84.32, 83.81 -51.72, -36.16 na-out-na SNCaoa out-na ActLoopNT-out 7.068 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.37, -43.07 APE9-dihe-na -65.03, -40.26 APE8-dihe-na -97.58, 14.32 APE8-rot-na 301.7 APE67-dihe-na 82.79, -63.67 -61.76, 133.26 APE12-dist-na 4.8968 APE11-dist-na 5.4715 APE10-dist-na 4.9808 APE9-dist-na 11.7452 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 F 438.0 408.0 8 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIG G0S0Y3 212 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.3451 12.7272 None -90.69, -14.9 -130.76, 66.96 -94.98, 143.34 287.45, 999.0 77.29, -3.15 out-na out 13.6864 Saltbr-na 999.0 HRD-out -84.86, 86.26 -50.94, -35.45 na-out-na SNCaoa out-na ActLoopNT-out 6.9562 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.27, -42.88 APE9-dihe-na -64.53, -40.74 APE8-dihe-na -98.57, 20.38 APE8-rot-na 300.7 APE67-dihe-na -82.95, -50.87 -54.99, -52.34 APE12-dist-na 4.8855 APE11-dist-na 5.4414 APE10-dist-na 4.9896 APE9-dist-na 11.838 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 G 438.0 397.0 11 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIH G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.5482 12.9926 None -92.58, -12.35 -130.21, 41.87 -74.5, 144.28 287.27, 999.0 78.55, -5.47 out-na out 13.5649 Saltbr-na 999.0 HRD-out -84.2, 83.95 -50.63, -35.15 na-out-na SNCaoa out-na ActLoopNT-out 7.1131 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.74, -43.44 APE9-dihe-na -64.3, -40.98 APE8-dihe-na -98.31, 13.33 APE8-rot-na 300.84 APE67-dihe-na 84.19, -53.66 -61.5, 130.17 APE12-dist-na 4.8973 APE11-dist-na 5.5511 APE10-dist-na 5.0041 APE9-dist-na 11.6791 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 H 438.0 407.0 7 16 16 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJA G0S0Y3 207 630 640.0 ATP:900 ATPlike Pseudo DFGin 8.6339 13.1429 None -107.98, -0.69 -128.2, 34.36 -65.03, -50.53 266.85, 999.0 -67.72, -27.44 out-na out 13.8242 Saltbr-na 999.0 HRD-out -72.25, 117.57 -98.06, -29.9 na-out-na SNCaoa out-na ActLoopNT-out 6.7342 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -76.94, -48.66 APE9-dihe-na -63.83, -32.83 APE8-dihe-na -105.44, 19.22 APE8-rot-na 294.5 APE67-dihe-na -75.63, -42.57 -53.51, -50.74 APE12-dist-na 4.8957 APE11-dist-na 5.5654 APE10-dist-na 4.767 APE9-dist-na 12.0929 None None None XRAY 2.59 0.185 0.221 A 438.0 403.0 9 16 16 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJB G0S0Y3 207 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.6566 13.4069 None -109.51, -3.14 -128.47, 33.06 -65.31, -51.07 267.08, 999.0 -68.09, -25.9 out-na out 13.6072 Saltbr-na 999.0 HRD-out -72.34, 112.57 -93.58, -28.7 na-out-na SNCaoa out-na ActLoopNT-out 6.7399 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.81, -47.86 APE9-dihe-na -64.66, -32.92 APE8-dihe-na -101.7, 13.23 APE8-rot-na 292.51 APE67-dihe-na 83.46, -7.05 -62.34, 118.45 APE12-dist-na 4.8265 APE11-dist-na 5.6867 APE10-dist-na 4.9609 APE9-dist-na 11.8917 None None None XRAY 2.59 0.185 0.221 B 438.0 412.0 10 16 16 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJC G0S0Y3 210 632 640.0 ATP:900 ATPlike Pseudo DFGin 8.6729 13.1643 None -108.29, -3.21 -129.06, 34.16 -64.55, -50.26 267.61, 999.0 -68.23, -27.03 out-na out 13.7221 Saltbr-na 999.0 HRD-out -71.32, 109.68 -92.82, -27.84 na-out-na SNCaoa out-na ActLoopNT-out 6.9283 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -75.12, -48.05 APE9-dihe-na -64.49, -35.42 APE8-dihe-na -104.77, 18.2 APE8-rot-na 294.69 APE67-dihe-na -54.66, -46.82 -53.38, -67.98 APE12-dist-na 4.8857 APE11-dist-na 5.6634 APE10-dist-na 4.9314 APE9-dist-na 11.8945 None None None XRAY 2.59 0.185 0.221 C 438.0 404.0 8 16 16 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJD G0S0Y3 207 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.7302 13.2458 None -109.91, -2.89 -127.7, 32.83 -63.98, -50.83 267.28, 999.0 -68.06, -27.82 out-na out 13.683 Saltbr-na 999.0 HRD-out -71.89, 115.33 -92.98, -30.13 na-out-na SNCaoa out-na ActLoopNT-out 6.6595 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.1, -45.9 APE9-dihe-na -60.82, -48.55 APE8-dihe-na -95.53, 14.82 APE8-rot-na 272.71 APE67-dihe-na -68.99, -42.68 -59.32, -45.4 APE12-dist-na 4.8928 APE11-dist-na 5.6895 APE10-dist-na 4.875 APE9-dist-na 11.9374 None None None XRAY 2.59 0.185 0.221 D 438.0 411.0 11 16 16 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4.0 286.0 283.0 410 411 412 414 416 288 304 308 390 392 391 393.0 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
AGC PRKACA KAPCA_CRIGR 6EMAA P25321 12 351 351.0 ATP:60401 ATPlike Active DFGin 6.8466 14.0282 BLAminus -121.3, 163.01 76.03, 95.19 -107.48, 29.41 285.05, 72.84 -63.27, -23.25 in-in in 8.5805 Saltbr-in 2.9123 HRD-in -88.06, -51.23 73.05, 9.34 in-in-in SNCiii in-in ActLoopNT-in 2.8434 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.85, 162.03 APE9-dihe-na 127.51, -167.2 APE8-dihe-in -113.51, 133.85 APE8-rot-in 299.54 APE67-dihe-in -58.99, -24.47 -49.7, -50.19 APE12-dist-in 8.208 APE11-dist-in 11.4336 APE10-dist-in 5.7768 APE9-dist-in 3.5854 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.88 0.184 0.213 A 353.0 340.0 0 25 25 0 [[44, 298]] 1.0 6ema Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6Y8CA P25321 13 351 351.0 ATP:60402 ATPlike Active DFGin 5.7272 14.3024 BLAminus -123.99, 172.57 69.5, 82.73 -92.15, 25.74 279.44, 63.0 -58.78, -31.82 in-in in 9.1661 Saltbr-in 2.6378 HRD-in -96.49, -52.39 69.1, 12.65 in-in-in SNCiii in-in ActLoopNT-in 2.8845 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.28, 160.42 APE9-dihe-na 122.78, -169.96 APE8-dihe-in -106.17, 134.07 APE8-rot-in 304.81 APE67-dihe-in -60.24, -22.7 -48.33, -48.43 APE12-dist-in 8.0442 APE11-dist-in 11.5168 APE10-dist-in 5.9394 APE9-dist-in 3.8952 None TPO198,SEP339 TPO198,SEP339 XRAY 1.76 0.162 0.19 A 353.0 339.0 0 25 25 0 [[44, 298]] 1.0 6y8c Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
TKL RIPK A0A811MC32_9POAL 8HOAA A0A811MC32 90 387 441.0 ATP:60701,HX2:60702 ATPlike,Allosteric Inactive DFGin 6.0609 12.6057 BLBplus -114.97, 161.69 65.77, 20.85 -71.65, 141.67 50.94, 88.04 74.58, 5.91 out-none out 13.156 Saltbr-none 999.0 HRD-out -77.34, 149.41 -82.88, -37.27 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 19.65 APE8-dihe-out -73.34, -23.03 APE8-rot-out 81.86 APE67-dihe-out 95.0, 11.7 -84.03, -15.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.2055 None None None XRAY 1.676 0.188 0.213 A 326.0 271.0 27 30 14 16 [[105, 385]] 1.0 8hoa Miscanthus lutarioriparius TKL_RIPK_9POAL TKL 1.9e-59 207.4 4.0 266.0 263.0 253 254 255 257 259 141 157 161 233 235 234 236.0 295 283 278 277 276 275 274 273 272 187 non-specific serine/threonine protein kinase
AGC PRKACA KAPCA_MOUSE 1ATPE P05132 16 351 351.0 ATP:60355 ATPlike Inactive DFGin 6.2296 14.5876 BLAminus -105.27, -165.6 48.73, 87.06 -105.12, 16.76 267.19, 75.22 -52.19, -32.07 in-out in 9.1613 Saltbr-out 3.6341 HRD-in -88.29, -43.64 51.81, 19.16 out-in-in SNCoii in-in ActLoopNT-in 2.8078 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.21, 146.28 APE9-dihe-na 146.09, -156.15 APE8-dihe-in -133.3, 119.84 APE8-rot-in 299.98 APE67-dihe-in -65.71, -15.81 -24.26, -60.76 APE12-dist-in 8.3526 APE11-dist-in 11.4096 APE10-dist-in 5.7064 APE9-dist-in 3.9902 None TPO198,SEP339 TPO198,SEP339 XRAY 2.2 0.177 999.0 E 350.0 336.0 0 25 25 0 [[44, 298]] 1.0 1atp Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3FJQE P05132 16 351 351.0 ATP:60403 ATPlike Active DFGin 5.6709 14.4589 BLAminus -119.42, 178.78 63.28, 80.04 -91.81, 23.31 270.73, 57.82 -56.09, -30.86 in-in in 9.1494 Saltbr-in 2.8344 HRD-in -91.33, -52.39 67.42, 13.87 in-in-in SNCiii in-in ActLoopNT-in 2.9056 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.19, 160.44 APE9-dihe-na 133.42, -155.21 APE8-dihe-in -125.75, 136.86 APE8-rot-in 304.0 APE67-dihe-in -61.0, -22.29 -48.87, -49.39 APE12-dist-in 8.0863 APE11-dist-in 11.4084 APE10-dist-in 5.8377 APE9-dist-in 3.5179 None TPO198,SEP339 TPO198,SEP339 XRAY 1.6 0.179 0.205 E 350.0 336.0 0 25 25 0 [[44, 298]] 1.0 3fjq Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DH1A P05132 16 351 351.0 ATP:60402 ATPlike Active DFGin 6.2341 14.3802 BLAminus -130.7, 167.11 69.97, 89.08 -103.01, 26.92 273.93, 57.95 -52.62, -33.38 in-in in 8.9305 Saltbr-in 3.0104 HRD-in -75.69, -51.31 65.95, 10.85 in-in-in SNCiii in-in ActLoopNT-in 2.8868 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.97, 163.54 APE9-dihe-na 128.87, -151.55 APE8-dihe-in -123.52, 135.53 APE8-rot-in 304.09 APE67-dihe-in -55.69, -26.94 -40.23, -59.36 APE12-dist-in 8.1686 APE11-dist-in 11.5574 APE10-dist-in 5.9503 APE9-dist-in 3.5446 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.0 0.199 0.234 A 350.0 336.0 0 25 25 0 [[44, 298]] 1.0 4dh1 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DH3A P05132 16 351 351.0 ATP:60403 ATPlike Active DFGin 5.9838 14.3792 BLAminus -125.47, 176.75 61.82, 79.89 -92.16, 24.39 276.69, 54.39 -43.39, -47.09 in-in in 9.021 Saltbr-in 2.7225 HRD-in -82.56, -48.22 66.04, -2.33 in-in-in SNCiii in-in ActLoopNT-in 2.9311 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.47, 165.55 APE9-dihe-na 126.96, -149.27 APE8-dihe-in -125.58, 130.88 APE8-rot-in 307.35 APE67-dihe-in -57.88, -25.54 -37.95, -56.15 APE12-dist-in 8.2249 APE11-dist-in 11.5925 APE10-dist-in 6.1036 APE9-dist-in 3.74 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.2 0.203 0.233 A 350.0 336.0 0 25 25 0 [[44, 298]] 1.0 4dh3 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DINA P05132 10 351 351.0 ATP:60400 ATPlike Inactive DFGin 5.792 13.1437 BLAminus -127.84, -176.29 51.22, 102.02 -109.69, 31.05 287.96, 58.2 -47.08, -31.2 in-in in 8.5177 Saltbr-in 3.4979 HRD-out -64.69, -78.02 71.93, 51.46 in-in-out SNCiio in-out ActLoopNT-in 2.9942 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -152.73, 153.23 APE9-dihe-na 130.84, -154.91 APE8-dihe-in -121.15, 137.05 APE8-rot-out 34.65 APE67-dihe-in -46.77, -45.03 -45.98, -63.1 APE12-dist-in 7.9722 APE11-dist-in 10.5875 APE10-dist-in 4.9968 APE9-dist-in 3.53 None TPO198,SEP339 TPO198,SEP339 XRAY 3.7 0.211 0.293 A 350.0 342.0 0 25 25 0 [[44, 298]] 1.0 4din Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4X6RA P05132 2 351 351.0 ATP:60402 ATPlike Active DFGin 6.1334 14.2323 BLAminus -118.92, 178.27 64.18, 79.91 -89.21, 11.01 274.1, 55.74 -49.19, -34.95 in-in in 8.8037 Saltbr-in 2.7288 HRD-in -85.13, -60.38 77.67, -7.87 in-in-in SNCiii in-in ActLoopNT-in 2.7182 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.34, 156.01 APE9-dihe-na 147.33, -149.7 APE8-dihe-in -130.56, 138.51 APE8-rot-in 291.09 APE67-dihe-in -61.2, -24.8 -52.44, -47.95 APE12-dist-in 8.281 APE11-dist-in 11.2462 APE10-dist-in 5.8359 APE9-dist-in 3.6632 K8C SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.4 0.186 0.234 A 350.0 350.0 0 25 25 0 [[44, 298]] 1.0 4x6r Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3X2UA P05132 13 351 351.0 ATP:60501 ATPlike Active DFGin 6.1271 14.5072 BLAminus -122.24, 178.58 59.36, 87.7 -101.54, 25.28 272.61, 50.83 -59.45, -24.26 in-in in 9.2723 Saltbr-in 2.7882 HRD-in -89.58, -50.62 64.84, 17.58 in-in-in SNCiii in-in ActLoopNT-in 2.9297 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.25, 158.3 APE9-dihe-na 134.88, -147.54 APE8-dihe-in -130.4, 131.58 APE8-rot-in 300.12 APE67-dihe-in -61.26, -14.4 -40.08, -55.22 APE12-dist-in 7.9122 APE11-dist-in 11.1375 APE10-dist-in 5.6863 APE9-dist-in 3.4266 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.4 0.202 0.239 A 357.0 339.0 0 25 25 0 [[44, 298]] 1.0 3x2u Mus musculus AGC_PRKACA_MOUSE AGC 1.6e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3X2VA P05132 18 351 351.0 ATP:60403 ATPlike Active DFGin 5.5167 14.1516 BLAminus -116.69, -175.94 62.92, 80.3 -91.77, 26.26 271.42, 55.44 -51.78, -39.79 in-in in 8.7552 Saltbr-in 2.6541 HRD-in -92.08, -50.84 67.69, 17.07 in-in-in SNCiii in-in ActLoopNT-in 2.8813 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.85, 164.45 APE9-dihe-na 134.14, -152.5 APE8-dihe-in -130.83, 133.42 APE8-rot-in 299.77 APE67-dihe-in -58.82, -21.18 -48.96, -48.11 APE12-dist-in 7.9982 APE11-dist-in 11.3458 APE10-dist-in 5.7964 APE9-dist-in 3.4149 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.77 0.185 0.23 A 357.0 334.0 0 25 25 0 [[44, 298]] 1.0 3x2v Mus musculus AGC_PRKACA_MOUSE AGC 1.6e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3X2WA P05132 13 351 351.0 ATP:60403 ATPlike Active DFGin 5.6602 14.3902 BLAminus -121.01, -177.68 63.51, 77.56 -90.4, 24.79 270.4, 59.29 -61.83, -28.06 in-in in 8.8217 Saltbr-in 2.6324 HRD-in -81.34, -52.24 70.22, 11.48 in-in-in SNCiii in-in ActLoopNT-in 2.9059 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.19, 162.39 APE9-dihe-na 132.4, -151.44 APE8-dihe-in -129.91, 133.08 APE8-rot-in 300.2 APE67-dihe-in -60.45, -20.83 -45.18, -51.38 APE12-dist-in 8.001 APE11-dist-in 11.4403 APE10-dist-in 5.911 APE9-dist-in 3.4498 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.7 0.165 0.198 A 357.0 339.0 0 25 25 0 [[44, 298]] 1.0 3x2w Mus musculus AGC_PRKACA_MOUSE AGC 1.6e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4XW5A P05132 15 351 351.0 ATP:60403 ATPlike Active DFGin 5.971 14.2215 BLAminus -131.24, 177.82 59.66, 87.19 -93.08, 25.08 282.37, 63.43 -53.77, -29.24 in-in in 9.2129 Saltbr-in 2.673 HRD-in -90.87, -48.94 63.52, 13.92 in-in-in SNCiii in-in ActLoopNT-in 2.8122 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.24, 155.03 APE9-dihe-na 137.47, -160.98 APE8-dihe-in -110.31, 133.6 APE8-rot-in 304.05 APE67-dihe-in -58.14, -25.36 -48.87, -50.12 APE12-dist-in 8.0264 APE11-dist-in 11.6005 APE10-dist-in 6.1002 APE9-dist-in 3.9217 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.95 0.185 0.252 A 356.0 337.0 0 25 25 0 [[44, 298]] 1.0 4xw5 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3QAME P05132 2 351 351.0 ATP:60351 ATPlike Active DFGin 5.5585 14.1896 BLAminus -125.2, -173.2 57.82, 79.24 -94.32, 24.42 273.28, 56.46 -52.36, -33.22 in-in in 8.9798 Saltbr-in 2.8042 HRD-in -80.54, -55.75 67.52, 12.49 in-in-in SNCiii in-in ActLoopNT-in 2.8883 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.45, 157.56 APE9-dihe-na 134.84, -152.56 APE8-dihe-in -129.9, 127.65 APE8-rot-in 298.13 APE67-dihe-in -57.31, -20.14 -26.19, -66.74 APE12-dist-in 8.0939 APE11-dist-in 11.2769 APE10-dist-in 5.8065 APE9-dist-in 3.475 E209A TPO198,SEP339 TPO198,SEP339 XRAY 1.92 0.195 0.228 E 350.0 350.0 0 25 25 0 [[44, 298]] 1.0 3qam Mus musculus AGC_PRKACA_MOUSE AGC 2.2e-93 318.2 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3QALE P05132 2 351 351.0 ATP:60351 ATPlike Active DFGin 5.6399 14.4013 BLAminus -123.21, -177.09 59.31, 80.89 -94.71, 25.93 269.1, 56.43 -54.28, -32.32 in-in in 9.0502 Saltbr-in 2.6578 HRD-in -84.64, -51.07 65.64, 14.74 in-in-in SNCiii in-in ActLoopNT-in 2.9615 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.61, 159.73 APE9-dihe-na 131.58, -155.18 APE8-dihe-in -126.66, 132.34 APE8-rot-in 301.51 APE67-dihe-in -57.77, -23.32 -31.31, -63.36 APE12-dist-in 8.0621 APE11-dist-in 11.3091 APE10-dist-in 5.7435 APE9-dist-in 3.5307 R281A TPO198,SEP339 TPO198,SEP339 XRAY 1.7 0.176 0.194 E 350.0 341.0 0 25 25 0 [[44, 298]] 1.0 3qal Mus musculus AGC_PRKACA_MOUSE AGC 4.5e-93 317.2 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 1RDQE P05132 2 351 351.0 ADP:60599,ATP:60600 ATPlike,ATPlike Active DFGin 5.7065 14.5148 BLAminus -117.27, 178.71 64.74, 81.19 -90.07, 21.82 270.96, 52.48 -58.25, -31.62 in-in in 9.0905 Saltbr-in 2.719 HRD-in -91.16, -53.36 73.19, 12.39 in-in-in SNCiii in-in ActLoopNT-in 2.9357 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.91, 159.57 APE9-dihe-na 132.64, -151.85 APE8-dihe-in -127.7, 133.09 APE8-rot-in 298.45 APE67-dihe-in -59.33, -27.24 -47.42, -47.34 APE12-dist-in 8.1158 APE11-dist-in 11.4138 APE10-dist-in 5.8307 APE9-dist-in 3.5208 Y205A TPO198,SEP339 TPO198,SEP339 XRAY 1.26 0.132 0.162 E 350.0 342.0 0 25 25 0 [[44, 298]] 1.0 1rdq Mus musculus AGC_PRKACA_MOUSE AGC 1.1e-92 315.9 1.0 260.0 260.0 184 185 186 188 190 73 92 96 164 166 165 167.0 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CAMK DAPK2 DAPK2_MOUSE 2YAAA Q8VDF3 12 311 370.0 ATP:61302 ATPlike Active DFGin 6.5313 14.2817 BLAminus -119.44, -173.75 61.63, 82.55 -100.44, 26.82 279.23, 73.82 -61.71, -30.38 in-in in 9.4366 Saltbr-in 2.945 HRD-in -69.91, -51.35 70.12, 4.4 in-in-in SNCiii in-in ActLoopNT-in 2.8304 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.66, 179.02 APE9-dihe-na 88.17, 165.82 APE8-dihe-in -83.03, 124.75 APE8-rot-in 307.34 APE67-dihe-in -54.24, -28.42 -45.93, -43.89 APE12-dist-in 8.6787 APE11-dist-in 11.5917 APE10-dist-in 6.3906 APE9-dist-in 4.9265 None None None XRAY 2.3 0.219 0.271 A 361.0 300.0 0 27 27 0 [[23, 285]] 1.0 2yaa Mus musculus CAMK_DAPK2_MOUSE CAMK 1.1e-93 319.4 1.0 256.0 256.0 170 171 172 174 176 52 74 78 146 148 147 149.0 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_MOUSE 2YAAB Q8VDF3 13 311 370.0 ATP:61302 ATPlike Inactive DFGin 6.5837 14.2887 BLAminus -119.54, -178.65 66.98, 88.67 -108.71, 24.01 280.41, 69.43 -62.37, -28.55 out-out out 10.1706 Saltbr-out 5.3765 HRD-in -72.87, -55.45 75.11, 6.49 out-in-in SNCoii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -174.59, 179.36 APE9-dihe-na 81.98, 166.79 APE8-dihe-in -83.03, 125.4 APE8-rot-in 303.87 APE67-dihe-in -54.18, -26.93 -45.18, -48.55 APE12-dist-in 8.7637 APE11-dist-in 11.5959 APE10-dist-in 6.4302 APE9-dist-in 4.8282 None None None XRAY 2.3 0.219 0.271 B 361.0 299.0 0 27 27 0 [[23, 285]] 1.0 2yaa Mus musculus CAMK_DAPK2_MOUSE CAMK 1.1e-93 319.4 1.0 256.0 256.0 170 171 172 174 176 52 74 78 146 148 147 149.0 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CMGC MAPK14 MK14_MOUSE 7Z9TBBB P47811 4 353 360.0 87B:401,ATP:402 Type3,Allosteric Inactive DFGin 5.8293 15.2444 BLBminus -103.34, -178.81 25.47, 89.69 -68.87, -161.65 315.54, 109.9 -76.7, 116.65 out-out out 10.3417 Saltbr-out 4.1791 HRD-in -67.82, -70.27 93.09, -17.91 out-out-out SNCooo out-out ActLoopNT-out 7.706 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -124.01, -67.71 APE9-dihe-na -98.04, -13.3 APE8-dihe-out -67.58, -39.12 APE8-rot-in 311.0 APE67-dihe-in -63.55, -21.3 -74.81, -8.77 APE12-dist-out 14.5958 APE11-dist-out 16.3559 APE10-dist-out 19.3522 APE9-dist-out 12.5383 None None None XRAY 2.6 0.202 0.254 BBB 359.0 350.0 0 25 25 0 [[24, 308]] 1.0 7z9t Mus musculus CMGC_MAPK14_MOUSE CMGC 5e-85 291.4 1.0 301.0 301.0 167 168 169 171 173 53 71 75 147 149 148 150.0 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
STE STK39 STK39_MOUSE 5D9HA Q9Z1W9 65 363 556.0 ATP:501 ATPlike Inactive DFGin 5.6858 16.4373 BLBtrans -110.31, 163.68 60.83, 61.1 -112.91, 152.73 160.61, 82.83 89.94, -129.86 out-out out 13.6821 Saltbr-out 14.1755 HRD-in -79.34, -55.51 78.38, -0.69 out-out-out SNCooo out-out ActLoopNT-out 7.7526 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 89.3 APE9-dihe-na 145.31, -162.33 APE8-dihe-in -128.36, 135.86 APE8-rot-out 189.19 APE67-dihe-in -54.38, -21.28 -96.66, 16.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 27.0541 APE9-dist-out 28.5465 None None None XRAY 3.1 0.24 0.269 A 348.0 290.0 9 33 26 7 [[75, 349]] 1.0 5d9h Mus musculus STE_STK39_MOUSE STE 1.3e-90 309.2 1.0 257.0 257.0 221 222 223 225 227 104 121 125 201 203 202 204.0 267 254 249 248 247 246 245 244 243 151 STE20/SPS1-related proline-alanine-rich protein kinase
STE STK39 STK39_MOUSE 5D9HB Q9Z1W9 65 364 556.0 ATP:501 ATPlike Inactive DFGin 5.6862 16.5571 BLBtrans -110.27, 163.88 60.61, 61.2 -112.96, 152.81 160.68, 82.77 89.89, -127.48 out-out out 13.7117 Saltbr-out 13.1009 HRD-in -78.11, -50.69 74.23, -12.16 out-out-out SNCooo out-out ActLoopNT-out 7.9127 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 140.15 APE8-dihe-in -87.12, 142.28 APE8-rot-out 185.38 APE67-dihe-in -78.59, -19.5 -91.99, 27.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 28.7069 None None None XRAY 3.1 0.24 0.269 B 348.0 293.0 7 33 26 7 [[75, 349]] 1.0 5d9h Mus musculus STE_STK39_MOUSE STE 1.3e-90 309.2 1.0 257.0 257.0 221 222 223 225 227 104 121 125 201 203 202 204.0 267 254 249 248 247 246 245 244 243 151 STE20/SPS1-related proline-alanine-rich protein kinase
TKL RIPK4 RIPK4_MOUSE 5WNIA Q9ERK0 9 288 786.0 ATP:403 ATPlike Inactive DFGin 5.0309 14.7639 BLAminus -137.21, -171.18 63.31, 81.36 -101.4, 15.3 283.28, 78.59 -51.45, -36.22 in-in in 8.6455 Saltbr-in 2.4821 HRD-in -76.93, -54.51 67.9, 5.7 in-in-out SNCiio in-out ActLoopNT-in 3.2042 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 127.03 APE9-dihe-na -72.21, -45.63 APE8-dihe-out -54.13, -30.5 APE8-rot-out 51.09 APE67-dihe-in -56.9, -38.97 -54.07, -35.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.4582 APE9-dist-out 11.3874 D143N None None XRAY 2.65 0.204 0.248 A 342.0 263.0 17 31 18 13 [[19, 285]] 1.0 5wni Mus musculus TKL_RIPK4_MOUSE TKL 1.4e-74 257.0 4.0 266.0 263.0 160 161 162 164 166 51 69 73 140 142 141 143.0 205 191 186 185 184 183 182 181 180 97 Receptor-interacting serine/threonine-protein kinase 4
CAMK PHKG1 PHKG1_RABIT 2PHKA P00518 15 291 387.0 ATP:60381 ATPlike Active DFGin 6.3547 14.9309 BLAminus -137.29, -164.32 48.12, 82.5 -104.58, 35.29 286.95, 71.57 -66.18, -30.51 in-in in 9.2235 Saltbr-in 2.8672 HRD-in -75.14, -51.03 75.46, 17.9 in-in-in SNCiii in-in ActLoopNT-in 2.8851 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.02, 157.52 APE9-dihe-na 142.39, -153.7 APE8-dihe-in -119.73, 129.29 APE8-rot-in 312.14 APE67-dihe-in -75.97, -3.06 -46.22, -51.97 APE12-dist-in 9.1878 APE11-dist-in 12.0375 APE10-dist-in 6.5648 APE9-dist-in 4.1866 None None None XRAY 2.6 0.253 0.3 A 277.0 277.0 0 27 27 0 [[20, 288]] 1.0 2phk Oryctolagus cuniculus CAMK_PHKG1_RABIT CAMK 3e-86 294.8 1.0 256.0 256.0 167 168 169 171 173 49 74 78 147 149 148 150.0 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK PHKG1 PHKG1_RABIT 1QL6A P00518 12 292 387.0 ATP:60301 ATPlike Active DFGin 6.3666 14.6137 BLAminus -136.63, -170.42 53.21, 74.77 -97.04, 26.39 287.52, 75.09 -70.06, -14.72 in-in in 9.2046 Saltbr-in 3.0996 HRD-in -59.97, -49.78 67.92, 7.3 in-in-in SNCiii in-in ActLoopNT-in 2.8963 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.76, 155.97 APE9-dihe-na 109.55, 169.96 APE8-dihe-in -76.43, 127.92 APE8-rot-in 308.32 APE67-dihe-in -67.24, -23.63 -51.61, -34.62 APE12-dist-in 9.2587 APE11-dist-in 11.4451 APE10-dist-in 6.1099 APE9-dist-in 4.369 E183S None None XRAY 2.4 0.24 0.33 A 298.0 281.0 0 27 27 0 [[20, 288]] 1.0 1ql6 Oryctolagus cuniculus CAMK_PHKG1_RABIT CAMK 5.1e-86 294.1 1.0 256.0 256.0 167 168 169 171 173 49 74 78 147 149 148 150.0 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK PHKG1 PHKG1_RABIT 1PHKA P00518 16 292 387.0 ATP:60381 ATPlike Active DFGin 6.147 14.3364 BLAminus -126.89, -173.45 56.12, 79.25 -99.09, 29.57 290.92, 76.23 -67.63, -19.58 in-in in 8.9934 Saltbr-in 2.8252 HRD-in -77.33, -46.36 68.03, 5.86 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.41, 147.14 APE9-dihe-na 116.4, 168.87 APE8-dihe-in -72.55, 120.48 APE8-rot-in 295.05 APE67-dihe-in -62.26, -27.58 -41.92, -42.38 APE12-dist-in 8.8358 APE11-dist-in 11.4296 APE10-dist-in 6.1569 APE9-dist-in 4.492 None None None XRAY 2.2 0.21 0.288 A 298.0 277.0 0 27 27 0 [[20, 288]] 1.0 1phk Oryctolagus cuniculus CAMK_PHKG1_RABIT CAMK 4e-86 294.4 1.0 256.0 256.0 167 168 169 171 173 49 74 78 147 149 148 150.0 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
STE MAP2K1 MP2K1_RABIT 2Y4IC P29678 37 381 393.0 ATP:1382 ATPlike Inactive DFGin 6.1966 13.7557 BLBplus -151.54, -176.33 53.75, 29.39 -91.07, 130.43 56.39, 97.48 -61.44, 113.3 out-out out 16.1319 Saltbr-out 15.7942 HRD-in -53.6, -47.94 74.29, -22.1 out-out-out SNCooo out-out ActLoopNT-out 9.9 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -108.6, -60.21 APE9-dihe-na 86.78, -165.04 APE8-dihe-out -116.15, -0.77 APE8-rot-out 172.84 APE67-dihe-out -107.13, 167.3 -126.53, 122.47 APE12-dist-out 16.2589 APE11-dist-out 19.1611 APE10-dist-out 21.2782 APE9-dist-out 14.8665 None None None XRAY 3.46 0.233 0.293 C 395.0 313.0 32 26 26 0 [[68, 361]] 1.0 2y4i Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.5e-97 331.3 1.0 257.0 257.0 207 208 209 211 213 97 114 118 187 189 188 190.0 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
OTHER FLS2 FLS2_ORYSJ 8JUPA Q0JA29 861 1176 1183.0 ATP:60401 ATPlike Inactive DFGin 6.1593 14.1808 BLAminus -129.46, 178.87 65.25, 87.62 -100.45, 24.31 288.53, 78.58 -69.31, -13.11 in-in in 7.7583 Saltbr-in 2.6348 HRD-in -73.88, -45.26 75.34, -0.8 in-in-out SNCiio in-out ActLoopNT-in 2.7582 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -97.88, 176.26 APE9-dihe-na 47.04, -123.5 APE8-dihe-out -91.29, -3.22 APE8-rot-out 60.74 APE67-dihe-in -61.44, -18.49 -67.89, -32.09 APE12-dist-out 23.4332 APE11-dist-out 18.4808 APE10-dist-out 19.3689 APE9-dist-out 12.3466 None None MSE903,MSE959,MSE1037,MSE1066,MSE1073,MSE1090,MSE1134,MSE1166,MSE1176 XRAY 1.98 0.202 0.221 A 327.0 286.0 30 39 23 16 [[874, 1175]] 1.0 8jup Oryza sativa OTHER_FLS2_ORYSJ TKL 3.2e-44 157.5 4.0 265.0 262.0 1030 1031 1032 1034 1036 908 926 930 1010 1012 1011 1013.0 1081 1069 1064 1063 1062 1061 1060 1059 1058 957 LRR receptor-like serine/threonine-protein kinase FLS2
CMGC CK1 Q8IIR9_PLAF7 5XVUA Q8IIR9 12 332 335.0 ATP:403 ATPlike Inactive DFGin 7.3209 16.711 BLAminus -110.04, -170.26 56.43, 69.12 -91.86, 16.9 294.29, 86.98 -66.48, -34.8 in-in in 9.4524 Saltbr-in 2.8021 HRD-in -73.92, -41.02 61.9, 9.67 in-in-out SNCiio in-out ActLoopNT-in 2.9655 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.27, 163.04 APE9-dihe-na 66.36, 159.74 APE8-dihe-in -64.44, 138.76 APE8-rot-out 161.92 APE67-dihe-in -63.63, -26.0 -45.45, -45.73 APE12-dist-in 12.799 APE11-dist-in 10.7805 APE10-dist-in 6.0039 APE9-dist-in 3.652 None None None XRAY 3.0 0.174 0.216 A 332.0 321.0 0 27 27 0 [[43, 328]] 1.0 5xvu Plasmodium falciparum CMGC_CK1_PLAF7 CMGC 2.9e-67 232.9 1.0 301.0 301.0 178 179 180 182 184 72 85 89 157 159 158 160.0 218 205 200 199 198 197 196 195 194 118 non-specific serine/threonine protein kinase
CMGC CK1 Q8IIR9_PLAF7 5XVUB Q8IIR9 12 332 335.0 ATP:404 ATPlike Inactive DFGin 7.401 16.6742 BLAminus -109.75, -170.19 56.85, 69.23 -92.76, 17.97 295.03, 87.19 -67.17, -35.33 in-in in 9.3006 Saltbr-in 2.7928 HRD-in -71.07, -41.36 62.96, 8.73 in-in-out SNCiio in-out ActLoopNT-in 2.8641 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -122.62, -85.86 APE9-dihe-na -52.99, 173.24 APE8-dihe-in -65.9, 138.47 APE8-rot-out 161.08 APE67-dihe-in -63.67, -25.37 -44.18, -46.51 APE12-dist-in 12.7437 APE11-dist-in 10.6152 APE10-dist-in 5.9411 APE9-dist-in 3.5974 None None None XRAY 3.0 0.174 0.216 B 332.0 321.0 0 27 27 0 [[43, 328]] 1.0 5xvu Plasmodium falciparum CMGC_CK1_PLAF7 CMGC 2.9e-67 232.9 1.0 301.0 301.0 178 179 180 182 184 72 85 89 157 159 158 160.0 218 205 200 199 198 197 196 195 194 118 non-specific serine/threonine protein kinase
CMGC CK1 Q8IIR9_PLAF7 5XVUC Q8IIR9 12 332 335.0 ATP:405 ATPlike Inactive DFGin 7.4919 16.7422 BLAminus -109.76, -170.14 57.17, 68.62 -92.1, 18.51 294.14, 87.94 -67.81, -35.21 in-in in 9.4558 Saltbr-in 2.8076 HRD-in -70.49, -40.6 62.72, 9.24 in-in-out SNCiio in-out ActLoopNT-in 2.9425 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -116.02, -79.39 APE9-dihe-na -60.1, 172.38 APE8-dihe-in -65.34, 140.21 APE8-rot-out 160.23 APE67-dihe-in -64.3, -24.41 -46.46, -45.68 APE12-dist-in 12.7405 APE11-dist-in 10.6424 APE10-dist-in 5.8451 APE9-dist-in 3.6324 None None None XRAY 3.0 0.174 0.216 C 332.0 321.0 0 27 27 0 [[43, 328]] 1.0 5xvu Plasmodium falciparum CMGC_CK1_PLAF7 CMGC 2.9e-67 232.9 1.0 301.0 301.0 178 179 180 182 184 72 85 89 157 159 158 160.0 218 205 200 199 198 197 196 195 194 118 non-specific serine/threonine protein kinase
CMGC MAPK1 MK01_RAT 4GT3A P63086 9 356 358.0 ATP:402 ATPlike Inactive DFGin 6.7027 16.1444 BLAminus -134.54, -176.44 66.94, 76.71 -104.84, 22.9 282.81, 76.31 -55.64, -34.0 in-none in 9.8171 Saltbr-none 999.0 HRD-in -69.89, -50.79 79.79, -14.59 none-in-out SNCnio in-out ActLoopNT-in 2.7761 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -105.46, -44.03 APE9-dihe-na -70.04, 169.29 APE8-dihe-in -70.71, 123.51 APE8-rot-in 309.48 APE67-dihe-in -61.98, -17.54 -56.41, -47.97 APE12-dist-out 14.2886 APE11-dist-in 11.0026 APE10-dist-in 6.7399 APE9-dist-in 4.4218 None None CME159 XRAY 1.68 0.168 0.2 A 364.0 348.0 0 31 31 0 [[23, 311]] 1.0 4gt3 Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.4e-85 293.1 1.0 301.0 301.0 164 165 166 168 170 52 69 73 144 146 145 147.0 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 1GOLA P63086 2 358 358.0 ATP:581 ATPlike Inactive DFGin 6.8401 16.5086 BLAminus -138.32, 175.35 71.89, 79.82 -106.15, 29.68 287.28, 71.38 -70.4, -19.75 out-none out 10.4077 Saltbr-none 999.0 HRD-in -68.54, -52.86 75.92, 1.19 none-in-out SNCnio in-out ActLoopNT-in 2.8991 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -103.2, -24.36 APE9-dihe-na -62.06, 164.48 APE8-dihe-in -61.17, 119.13 APE8-rot-in 302.33 APE67-dihe-in -53.15, -25.45 -41.46, -58.53 APE12-dist-out 14.3386 APE11-dist-in 11.2075 APE10-dist-in 7.401 APE9-dist-in 4.2815 K52R None None XRAY 2.8 999.0 999.0 A 364.0 357.0 0 31 31 0 [[23, 311]] 1.0 1gol Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.4e-84 289.8 1.0 301.0 301.0 164 165 166 168 170 52 69 73 144 146 145 147.0 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
STE TAOK2 TAOK2_RAT 1U5RA Q9JLS3 12 320 1235.0 ATP:411 ATPlike Active DFGin 6.9896 14.2399 BLAminus -128.27, -174.18 56.24, 80.49 -99.99, 21.83 293.09, 83.93 -60.11, -26.41 in-in in 8.687 Saltbr-in 2.8872 HRD-in -75.95, -53.43 76.2, -2.14 in-in-in SNCiii in-in ActLoopNT-in 2.7667 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.19, 153.0 APE9-dihe-na 135.08, -166.49 APE8-dihe-in -116.65, 119.51 APE8-rot-in 301.53 APE67-dihe-in -56.87, -24.9 -27.41, -63.55 APE12-dist-in 8.4456 APE11-dist-in 11.3907 APE10-dist-in 5.5071 APE9-dist-in 3.2793 None SEP181 SEP181 XRAY 2.1 0.211 0.244 A 348.0 309.0 0 24 24 0 [[28, 281]] 1.0 1u5r Rattus norvegicus STE_TAOK2_RAT STE 1.4e-89 305.8 2.0 257.0 256.0 168 169 170 172 174 57 76 80 148 150 149 151.0 207 192 187 186 185 184 183 182 181 106 Serine/threonine-protein kinase TAO2
STE TAOK2 TAOK2_RAT 1U5RB Q9JLS3 12 320 1235.0 ATP:412 ATPlike Active DFGin 6.7633 13.8958 BLAminus -129.03, -178.62 56.08, 82.23 -96.99, 22.88 295.53, 83.61 -63.46, -23.11 in-in in 8.7722 Saltbr-in 2.6231 HRD-in -71.62, -50.86 71.95, 2.83 in-in-in SNCiii in-in ActLoopNT-in 2.7763 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.4, 155.39 APE9-dihe-na 130.83, -165.29 APE8-dihe-in -116.7, 116.24 APE8-rot-in 302.47 APE67-dihe-in -61.68, -22.51 -24.84, -62.59 APE12-dist-in 8.9051 APE11-dist-in 11.0198 APE10-dist-in 5.2819 APE9-dist-in 3.304 None SEP181 SEP181 XRAY 2.1 0.211 0.244 B 348.0 309.0 0 24 24 0 [[28, 281]] 1.0 1u5r Rattus norvegicus STE_TAOK2_RAT STE 1.4e-89 305.8 2.0 257.0 256.0 168 169 170 172 174 57 76 80 148 150 149 151.0 207 192 187 186 185 184 183 182 181 106 Serine/threonine-protein kinase TAO2
CMGC CKA1 CSK21_YEAST 4FI1A P15790 1 371 372.0 ATP:403 ATPlike Inactive None 23.9376 16.2374 None -116.2, -173.62 60.19, 79.18 -100.6, 15.4 291.83, 86.61 -72.61, -17.46 out-na out 37.8579 Saltbr-na 999.0 HRD-in -72.28, -48.07 67.04, 8.76 na-in-out SNCaio in-out ActLoopNT-in 2.9261 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.66, 175.92 APE9-dihe-na 60.75, -165.68 APE8-dihe-in -116.66, 152.71 APE8-rot-out 187.49 APE67-dihe-in -64.93, -21.65 -39.27, -55.57 APE12-dist-in 12.7411 APE11-dist-in 10.9227 APE10-dist-in 6.0716 APE9-dist-in 3.4192 None None None XRAY 2.09 0.206 0.243 A 374.0 371.0 0 27 27 0 [[100, 363]] 1.0 4fi1 Saccharomyces cerevisiae CMGC_CKA1_YEAST CMGC 0.0001 199.7 1.0 55.0 321.0 213 214 215 217 219 69 114 118 192 194 193 195.0 253 240 235 234 233 232 231 230 229 153 Casein kinase II subunit alpha
CMGC CKA1 CSK21_YEAST 4MWHA P15790 1 371 372.0 ATP:401 ATPlike Inactive None 23.9776 16.2185 None -116.51, -173.69 61.16, 78.03 -99.81, 14.04 291.24, 86.36 -72.33, -17.88 out-na out 37.853 Saltbr-na 999.0 HRD-in -70.43, -48.46 67.2, 9.69 na-in-out SNCaio in-out ActLoopNT-in 2.9601 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -135.3, 175.12 APE9-dihe-na 58.95, -171.53 APE8-dihe-in -112.48, 153.51 APE8-rot-out 184.1 APE67-dihe-in -66.06, -21.26 -39.33, -54.63 APE12-dist-in 12.7311 APE11-dist-in 10.9232 APE10-dist-in 6.0707 APE9-dist-in 3.4788 None None None XRAY 2.09 0.199 0.241 A 374.0 371.0 0 27 27 0 [[100, 363]] 1.0 4mwh Saccharomyces cerevisiae CMGC_CKA1_YEAST CMGC 0.0001 199.7 1.0 55.0 321.0 213 214 215 217 219 69 114 118 192 194 193 195.0 253 240 235 234 233 232 231 230 229 153 Casein kinase II subunit alpha
CMGC SKY1 SKY1_YEAST 1Q97A Q03656 144 737 742.0 ATP:60485 ATPlike Active DFGin 5.605 12.6475 BLAminus -113.61, -176.06 45.65, 81.54 -92.49, 25.33 294.84, 21.0 -61.4, -14.56 in-in in 8.92 Saltbr-in 2.9102 HRD-in -73.18, -42.39 69.86, -2.96 in-in-in SNCiii in-in ActLoopNT-in 2.9854 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.18, 168.88 APE9-dihe-na 68.54, 141.02 APE8-dihe-in -74.6, 131.99 APE8-rot-in 300.34 APE67-dihe-in -58.79, -28.16 -13.13, -73.4 APE12-dist-in 12.5859 APE11-dist-in 10.4977 APE10-dist-in 7.6309 APE9-dist-in 3.163 None None None XRAY 2.3 0.215 0.264 A 373.0 351.0 11 25 25 0 [[158, 706]] 1.0 1q97 Saccharomyces cerevisiae CMGC_SKY1_YEAST CMGC 8.8e-100 339.7 1.0 301.0 301.0 549 550 551 553 555 187 202 206 291 293 292 294.0 586 574 569 568 567 566 565 564 563 247 Serine/threonine-protein kinase SKY1
OTHER GCN2-2 GCN2_YEAST 1ZYDA P15442 594 996 1659.0 ATP:60303 ATPlike Inactive DFGin 6.4103 14.1059 BLBminus -140.51, -168.68 57.3, 45.16 -50.27, 137.38 287.66, 72.18 -82.02, 105.81 out-out out 12.8009 Saltbr-out 11.5022 HRD-in -64.16, -46.0 70.86, 0.79 out-out-out SNCooo out-out ActLoopNT-out 8.8327 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 87.46 APE9-dihe-na 82.34, -63.68 APE8-dihe-out -63.29, -19.6 APE8-rot-out 172.58 APE67-dihe-in -77.43, -0.66 -78.79, -26.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.861 APE9-dist-out 12.0935 None None None XRAY 2.75 0.208 0.27 A 303.0 268.0 32 42 16 26 [[292, 527], [599, 981]] 2.0 1zyd Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 7.9e-45 164.1 2.0 254.0 253.0 852 853 854 856 858 628 643 647 832 834 833 835.0 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
OTHER GCN2-2 GCN2_YEAST 1ZYDB P15442 594 983 1659.0 ATP:60304 ATPlike Inactive DFGin 6.5576 14.1835 BLBminus -148.24, -169.36 49.61, 62.39 -64.34, 151.67 288.08, 61.76 -84.72, 102.57 out-out out 12.6474 Saltbr-out 11.1618 HRD-in -64.07, -43.6 67.43, 4.77 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 127.88 APE9-dihe-na -94.37, -36.47 APE8-dihe-out -54.75, -25.46 APE8-rot-in 302.91 APE67-dihe-in -57.91, -12.21 -57.71, -47.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.7885 APE9-dist-out 11.857 None None None XRAY 2.75 0.208 0.27 B 303.0 251.0 36 42 15 27 [[292, 527], [599, 981]] 2.0 1zyd Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 7.9e-45 164.1 2.0 254.0 253.0 852 853 854 856 858 628 643 647 832 834 833 835.0 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
CK1 CKI1 CKI1_SCHPO 1CSNA P40233 6 298 446.0 ATP:299 ATPlike Active DFGin 6.4218 13.7895 BLAminus -124.8, 177.22 63.85, 88.12 -109.85, 36.77 298.25, 97.14 -71.61, -21.33 in-in in 8.0396 Saltbr-in 3.0859 HRD-in -68.74, -48.02 63.6, 9.84 in-in-in SNCiii in-in ActLoopNT-in 2.8146 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -97.61, -90.82 APE9-dihe-na -65.25, -165.09 APE8-dihe-in -55.42, 111.92 APE8-rot-in 313.89 APE67-dihe-in -55.02, -31.3 -55.98, -42.83 APE12-dist-in 12.7405 APE11-dist-in 13.0074 APE10-dist-in 7.1601 APE9-dist-in 4.7937 None None None XRAY 2.0 0.207 999.0 A 298.0 293.0 0 35 35 0 [[12, 280]] 1.0 1csn Schizosaccharomyces pombe CK1_CKI1_SCHPO CK1 8e-95 323.1 1.0 261.0 261.0 153 154 155 157 159 41 55 59 128 130 129 131.0 200 188 183 182 181 180 179 178 177 86 Casein kinase I homolog 1