Ligand: ATP

Total number of chains: 173
Active chains: 68
Total number of genes: 31
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 112 64.7% 5LVOA
DFGin BLBplus 21 12.1% 3DKCA
DFGinter None 14 8.1% 9D5IA
DFGin None 12 6.9% 5I4NA
DFGin BLBtrans 6 3.5% 1HCKA
DFGin ABAminus 4 2.3% 7T4TA
None None 3 1.7% 4FG8B
DFGout None 1 0.6% 8FO9E
All chains - renumbered by
Uniprot PDB Alignment

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Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
AGC GRK5 GRK5_HUMAN 9CKRA P34947 25 542 590.0 ATP:603 ATPlike Active DFGin 6.172 12.867 BLAminus -123.04, 159.77 67.48, 80.75 -99.52, 5.04 278.7, 83.61 -52.63, -21.44 in-in in 8.589 Saltbr-in 3.447 HRD-in -94.88, -52.49 68.7, 5.59 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.66, 167.59 APE9-dihe-na 129.66, -152.54 APE8-dihe-in -119.66, 138.17 APE8-rot-in 320.31 APE67-dihe-inflip 80.19, -6.12 -54.38, 134.58 APE12-dist-in 9.872 APE11-dist-in 12.258 APE10-dist-in 6.529 APE9-dist-in 4.181 D311N None None XRAY 2.8 0.239 0.286 A 598 501 0 0 0 0 [[186, 448]] 1.0 9ckr AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9CKSA P34947 25 542 590.0 ATP:603 ATPlike Active DFGin 6.038 13.061 BLAminus -123.04, 167.6 79.98, 56.79 -87.17, 17.84 285.5, 62.72 -70.38, -31.79 in-in in 9.222 Saltbr-in 2.672 HRD-in -92.29, -53.7 68.73, 3.48 in-in-in SNCiii in-in ActLoopNT-in 2.963 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.24, 151.24 APE9-dihe-na 138.17, -158.29 APE8-dihe-in -117.35, 145.2 APE8-rot-in 310.61 APE67-dihe-inflip 85.98, -22.04 -53.6, 135.84 APE12-dist-in 10.616 APE11-dist-in 12.407 APE10-dist-in 6.563 APE9-dist-in 4.207 D311N None None XRAY 3.08 0.228 0.28 A 598 501 0 0 0 0 [[186, 448]] 1.0 9cks AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC PDPK1 PDPK1_HUMAN 1H1WA O15530 71 359 556.0 ATP:1373 ATPlike Inactive DFGin 6.612 14.931 BLAminus -145.26, -169.97 71.92, 72.18 -105.82, -0.04 289.27, 102.08 -58.33, -31.92 in-in in 8.581 Saltbr-in 2.71 HRD-in -71.45, -48.32 74.08, -8.04 in-in-out SNCiio in-out ActLoopNT-in 2.84 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -131.69, 112.94 APE9-dihe-na -63.98, -168.66 APE8-dihe-in -54.13, 124.0 APE8-rot-in 301.59 APE67-dihe-in -62.54, -19.03 -38.83, -50.46 APE12-dist-in 8.922 APE11-dist-out 5.528 APE10-dist-out 10.298 APE9-dist-in 3.799 None SEP241 SEP241 XRAY 2.0 0.196 0.223 A 289 285 4 0 0 4 [[82, 342]] 1.0 1h1w AGC_PDPK1_HUMAN AGC 9.8e-85 289.7 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 2BIYA O15530 72 359 556.0 ATP:1373 ATPlike Active DFGin 6.619 15.095 BLAminus -141.33, -175.84 82.91, 67.67 -104.99, 1.58 283.05, 104.18 -61.63, -33.06 in-in in 8.673 Saltbr-in 2.575 HRD-in -63.52, -52.73 78.44, -11.09 in-in-in SNCiii in-in ActLoopNT-in 2.82 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -88.22, 130.12 APE9-dihe-na 106.71, 171.13 APE8-dihe-in -96.94, 126.07 APE8-rot-in 299.07 APE67-dihe-in -62.15, -19.51 -52.23, -44.36 APE12-dist-in 12.868 APE11-dist-in 12.869 APE10-dist-in 7.268 APE9-dist-in 4.745 S241A None None XRAY 1.95 0.186 0.23 A 310 288 0 0 0 0 [[82, 342]] 1.0 2biy AGC_PDPK1_HUMAN AGC 1.8e-84 288.8 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3HRCA O15530 76 359 556.0 ATP:1373 ATPlike Active DFGin 6.486 14.833 BLAminus -136.91, -178.17 71.81, 74.55 -104.54, 6.98 286.89, 102.51 -65.47, -24.41 in-in in 8.421 Saltbr-in 3.159 HRD-in -77.24, -54.93 76.93, -11.42 in-in-in SNCiii in-in ActLoopNT-in 2.87 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.25, 162.0 APE9-dihe-na 130.63, -171.63 APE8-dihe-in -125.01, 129.68 APE8-rot-in 292.48 APE67-dihe-in -58.92, -25.29 -45.32, -48.7 APE12-dist-in 7.409 APE11-dist-in 10.582 APE10-dist-in 4.926 APE9-dist-in 3.479 Y288G,Q292A SEP241 SEP241 XRAY 1.91 0.182 0.207 A 311 280 4 0 0 4 [[82, 342]] 1.0 3hrc AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4RRVA O15530 76 359 556.0 ATP:60401 ATPlike Active DFGin 6.548 14.998 BLAminus -136.55, -175.99 74.63, 72.8 -106.52, 5.78 286.61, 100.18 -68.12, -17.88 in-in in 8.52 Saltbr-in 2.956 HRD-in -71.77, -54.29 78.75, -11.73 in-in-in SNCiii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.13, 162.83 APE9-dihe-na 132.08, -169.67 APE8-dihe-in -127.24, 132.02 APE8-rot-in 298.33 APE67-dihe-in -59.21, -24.3 -51.83, -46.04 APE12-dist-in 7.281 APE11-dist-in 10.502 APE10-dist-in 4.943 APE9-dist-in 3.569 Y288G,Q292A SEP241 SEP241 XRAY 1.412 0.135 0.163 A 311 284 0 0 0 0 [[82, 342]] 1.0 4rrv AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5ACKA O15530 73 359 556.0 ATP:500 ATPlike Active DFGin 6.615 14.861 BLAminus -135.34, 179.84 72.22, 79.01 -106.01, 4.14 287.93, 97.64 -67.02, -18.73 in-in in 8.418 Saltbr-in 2.583 HRD-in -74.68, -53.67 78.01, -12.73 in-in-in SNCiii in-in ActLoopNT-in 2.906 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.4, 162.51 APE9-dihe-na 136.44, -168.07 APE8-dihe-in -132.35, 133.52 APE8-rot-in 296.36 APE67-dihe-in -62.96, -23.95 -54.34, -43.19 APE12-dist-in 7.326 APE11-dist-in 10.522 APE10-dist-in 4.978 APE9-dist-in 3.558 Y288G,Q292A SEP241 SEP241 XRAY 1.24 0.143 0.166 A 311 287 0 0 0 0 [[82, 342]] 1.0 5ack AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVPA O15530 75 359 556.0 ATP:500 ATPlike Active DFGin 6.303 14.998 BLAminus -144.92, -168.82 66.06, 77.78 -108.23, 11.17 281.99, 93.22 -63.04, -32.41 in-in in 9.539 Saltbr-in 3.158 HRD-in -77.47, -51.83 79.92, -12.48 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.64, 166.02 APE9-dihe-na 141.61, 177.5 APE8-dihe-in -123.02, 134.29 APE8-rot-in 296.02 APE67-dihe-in -68.65, -16.53 -46.89, -50.92 APE12-dist-in 7.907 APE11-dist-in 10.671 APE10-dist-in 5.166 APE9-dist-in 3.705 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 A 311 276 9 0 0 9 [[82, 342]] 1.0 5lvp AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVPB O15530 74 359 556.0 ATP:401 ATPlike Active DFGin 6.328 14.55 BLAminus -137.23, -179.71 80.14, 74.16 -105.47, 15.38 295.0, 84.83 -59.91, -31.47 in-in in 9.274 Saltbr-in 3.302 HRD-in -80.68, -44.41 73.96, -16.23 in-in-in SNCiii in-in ActLoopNT-in 2.744 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.8, 152.43 APE9-dihe-na 134.43, -173.75 APE8-dihe-in -120.09, 128.28 APE8-rot-in 302.93 APE67-dihe-in -67.56, -25.72 -44.99, -47.55 APE12-dist-in 7.872 APE11-dist-in 11.011 APE10-dist-in 5.375 APE9-dist-in 3.787 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 B 311 277 9 0 0 9 [[82, 342]] 1.0 5lvp AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVPC O15530 75 359 556.0 ATP:401 ATPlike Active DFGin 6.391 14.608 BLAminus -132.15, -176.81 71.98, 84.02 -116.53, 7.62 291.47, 90.46 -60.24, -24.5 in-in in 9.304 Saltbr-in 3.087 HRD-in -75.92, -52.06 78.45, -5.49 in-in-in SNCiii in-in ActLoopNT-in 2.823 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.81, 168.64 APE9-dihe-na 131.92, -176.79 APE8-dihe-in -126.79, 133.21 APE8-rot-in 299.13 APE67-dihe-in -67.64, -15.8 -51.62, -50.49 APE12-dist-in 7.652 APE11-dist-in 10.863 APE10-dist-in 5.123 APE9-dist-in 3.645 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 C 311 276 9 0 0 9 [[82, 342]] 1.0 5lvp AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVPD O15530 74 359 556.0 ATP:500 ATPlike Active DFGin 6.334 14.433 BLAminus -146.99, -174.22 74.22, 81.56 -113.84, 4.02 287.97, 93.59 -56.11, -25.73 in-in in 9.304 Saltbr-in 3.252 HRD-in -82.38, -50.18 78.4, -12.51 in-in-in SNCiii in-in ActLoopNT-in 2.836 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.65, 165.17 APE9-dihe-na 129.1, -166.82 APE8-dihe-in -132.84, 129.79 APE8-rot-in 300.06 APE67-dihe-in -65.46, -17.03 -48.9, -48.47 APE12-dist-in 8.228 APE11-dist-in 10.891 APE10-dist-in 5.348 APE9-dist-in 3.646 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 D 311 277 9 0 0 9 [[82, 342]] 1.0 5lvp AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4CT2A O15530 75 359 556.0 ATP:500 ATPlike Active DFGin 6.551 14.867 BLAminus -136.23, -174.98 70.54, 70.07 -102.02, 6.41 290.69, 95.78 -63.73, -21.59 in-in in 8.252 Saltbr-in 2.643 HRD-in -73.2, -54.84 77.37, -9.78 in-in-in SNCiii in-in ActLoopNT-in 2.965 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.02, 163.59 APE9-dihe-na 137.39, -170.05 APE8-dihe-in -132.12, 131.72 APE8-rot-in 295.26 APE67-dihe-in -63.06, -17.27 -51.84, -45.87 APE12-dist-in 7.163 APE11-dist-in 10.524 APE10-dist-in 4.979 APE9-dist-in 3.527 L113V,I118V,I119H,V124I,T128Q,R131K,T148C,F157L,Y288G,Q292A SEP241 SEP241 XRAY 1.25 0.194 0.226 A 311 280 5 0 0 0 [[82, 342]] 1.0 4ct2 AGC_PDPK1_HUMAN AGC 9.5e-84 286.4 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5MRDA O15530 76 359 556.0 ATP:405 ATPlike Active DFGin 6.429 14.7 BLAminus -133.69, -177.11 74.21, 73.9 -105.88, 9.0 289.39, 99.64 -68.32, -19.62 in-in in 8.346 Saltbr-in 2.667 HRD-in -74.32, -53.19 77.26, -10.58 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.86, 160.68 APE9-dihe-na 136.11, -166.87 APE8-dihe-in -131.1, 132.63 APE8-rot-in 296.36 APE67-dihe-in -62.36, -23.28 -53.02, -44.84 APE12-dist-in 7.352 APE11-dist-in 10.498 APE10-dist-in 4.91 APE9-dist-in 3.542 K76S,L113V,I118V,I119N,V124I,T128Q,R131K,T148C SEP241 SEP241 XRAY 1.41 0.142 0.174 A 310 284 0 0 0 0 [[82, 342]] 1.0 5mrd AGC_PDPK1_HUMAN AGC 1.7e-83 285.6 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3HRFA O15530 75 359 556.0 ATP:1373,P47:1374 ATPlike,Allosteric Active DFGin 6.514 14.784 BLAminus -133.77, -176.11 75.25, 77.12 -110.83, 6.58 287.55, 100.98 -63.85, -22.79 in-in in 8.387 Saltbr-in 2.701 HRD-in -73.67, -53.98 76.59, -10.73 in-in-in SNCiii in-in ActLoopNT-in 2.923 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.42, 166.15 APE9-dihe-na 124.75, -165.6 APE8-dihe-in -127.97, 128.5 APE8-rot-in 295.31 APE67-dihe-in -62.28, -24.12 -44.34, -47.42 APE12-dist-in 7.351 APE11-dist-in 10.546 APE10-dist-in 4.867 APE9-dist-in 3.481 Y288G,Q292A SEP241 SEP241 XRAY 1.9 0.165 0.177 A 311 285 0 0 0 0 [[82, 342]] 1.0 3hrf AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4A06A O15530 75 359 556.0 ATP:500,A06:600 ATPlike,Allosteric Active DFGin 6.512 14.757 BLAminus -135.73, -177.17 74.25, 74.67 -110.25, 11.82 284.97, 101.73 -68.23, -22.46 in-in in 8.319 Saltbr-in 2.864 HRD-in -73.73, -51.84 74.62, -10.07 in-in-in SNCiii in-in ActLoopNT-in 2.92 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.65, 165.25 APE9-dihe-na 128.95, -173.35 APE8-dihe-in -120.15, 131.51 APE8-rot-in 299.31 APE67-dihe-in -59.46, -27.29 -45.75, -47.91 APE12-dist-in 7.336 APE11-dist-in 10.447 APE10-dist-in 4.873 APE9-dist-in 3.509 Y288G,Q292A SEP241 SEP241 XRAY 2.0 0.161 0.198 A 311 285 0 0 0 0 [[82, 342]] 1.0 4a06 AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4AW0A O15530 75 359 556.0 ATP:500,MJF:600 ATPlike,Allosteric Active DFGin 6.531 14.993 BLAminus -134.84, 177.25 78.73, 76.19 -106.3, 8.53 283.51, 97.11 -69.63, -19.36 in-in in 8.595 Saltbr-in 3.009 HRD-in -83.05, -53.03 79.45, -12.94 in-in-in SNCiii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.69, 159.04 APE9-dihe-na 139.48, -167.8 APE8-dihe-in -131.87, 132.42 APE8-rot-in 295.45 APE67-dihe-in -61.29, -25.28 -54.74, -42.17 APE12-dist-in 7.509 APE11-dist-in 10.601 APE10-dist-in 5.026 APE9-dist-in 3.58 Y288G,Q292A SEP241 SEP241,CME260 XRAY 1.43 0.171 0.188 A 311 285 0 0 0 0 [[82, 342]] 1.0 4aw0 AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4AW1A O15530 66 359 556.0 ATP:1360,21O:1361 ATPlike,Allosteric Active DFGin 6.325 14.155 BLAminus -137.24, -178.23 68.96, 84.69 -105.37, 17.06 286.01, 86.79 -62.77, -26.7 in-in in 8.576 Saltbr-in 2.864 HRD-in -81.18, -54.06 78.32, -13.29 in-in-in SNCiii in-in ActLoopNT-in 2.849 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.98, 160.2 APE9-dihe-na 130.22, -162.57 APE8-dihe-in -126.98, 128.72 APE8-rot-in 295.96 APE67-dihe-in -57.45, -24.35 -48.01, -47.7 APE12-dist-in 7.653 APE11-dist-in 10.852 APE10-dist-in 5.075 APE9-dist-in 3.586 Y288G,Q292A SEP241 SEP241 XRAY 1.68 0.165 0.186 A 311 287 5 0 0 5 [[82, 342]] 1.0 4aw1 AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4RQKA O15530 74 359 556.0 ATP:403,R1S:404 ATPlike,Allosteric Active DFGin 6.461 14.786 BLAminus -139.06, -177.03 75.27, 72.83 -105.25, 7.36 287.3, 98.33 -64.7, -21.38 in-in in 8.464 Saltbr-in 2.941 HRD-in -73.98, -52.31 74.79, -9.31 in-in-in SNCiii in-in ActLoopNT-in 2.88 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.64, 164.69 APE9-dihe-na 126.87, -171.23 APE8-dihe-in -124.75, 130.48 APE8-rot-in 298.57 APE67-dihe-in -59.79, -23.66 -48.31, -47.88 APE12-dist-in 7.244 APE11-dist-in 10.466 APE10-dist-in 4.918 APE9-dist-in 3.544 Y288G,Q292A SEP241 SEP241 XRAY 1.55 0.133 0.167 A 311 286 0 0 0 0 [[82, 342]] 1.0 4rqk AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4RQVA O15530 71 359 556.0 ATP:405,R2S:406 ATPlike,Allosteric Active DFGin 6.492 14.954 BLAminus -139.41, -174.88 74.87, 69.78 -102.0, 7.85 285.85, 94.73 -65.11, -21.56 in-in in 8.256 Saltbr-in 2.772 HRD-in -72.94, -52.57 74.87, -10.5 in-in-in SNCiii in-in ActLoopNT-in 2.916 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.07, 164.19 APE9-dihe-na 130.69, -171.7 APE8-dihe-in -126.67, 130.74 APE8-rot-in 297.63 APE67-dihe-in -61.47, -23.77 -49.17, -46.26 APE12-dist-in 7.253 APE11-dist-in 10.488 APE10-dist-in 4.969 APE9-dist-in 3.513 Y288G,Q292A SEP241 SEP241 XRAY 1.502 0.133 0.166 A 311 289 0 0 0 0 [[82, 342]] 1.0 4rqv AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVOA O15530 73 359 556.0 ATP:401,78W:402 ATPlike,Allosteric Active DFGin 6.581 15.005 BLAminus -134.78, 179.9 79.12, 70.17 -103.55, 0.25 286.72, 100.66 -64.63, -19.63 in-in in 8.588 Saltbr-in 2.631 HRD-in -71.89, -54.41 77.65, -9.82 in-in-in SNCiii in-in ActLoopNT-in 2.919 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.78, 162.52 APE9-dihe-na 134.75, -167.11 APE8-dihe-in -130.46, 134.12 APE8-rot-in 296.12 APE67-dihe-in -62.26, -22.94 -53.92, -45.37 APE12-dist-in 7.45 APE11-dist-in 10.558 APE10-dist-in 4.984 APE9-dist-in 3.553 Y288G,Q292A SEP241 SEP241 XRAY 1.09 0.136 0.157 A 311 287 0 0 0 0 [[82, 342]] 1.0 5lvo AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4CT1A O15530 76 359 556.0 ATP:500,31S:600 ATPlike,Allosteric None DFGin 6.602 14.979 BLAminus -141.71, -172.51 72.43, 72.08 -107.06, 8.07 284.9, 97.13 -62.67, -20.12 in-none in 8.146 Saltbr-none 999.0 HRD-in -74.62, -54.47 79.43, -8.97 none-in-in SNCnii in-in ActLoopNT-in 2.999 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.29, 160.89 APE9-dihe-na 137.85, -171.95 APE8-dihe-in -126.26, 129.35 APE8-rot-in 296.2 APE67-dihe-in -61.08, -24.26 -47.64, -46.5 APE12-dist-in 7.357 APE11-dist-in 10.489 APE10-dist-in 5.018 APE9-dist-in 3.48 L113V,I118V,I119H,V124I,T128Q,R131K,T148C,F157L,Y288G,Q292A SEP241 SEP241 XRAY 1.85 0.172 0.215 A 311 284 0 0 0 0 [[82, 342]] 1.0 4ct1 AGC_PDPK1_HUMAN AGC 9.5e-84 286.4 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4XX9A O15530 71 359 556.0 ATP:401,RF4:402,RF4:403 ATPlike,Allosteric,Allosteric Active DFGin 6.513 14.988 BLAminus -138.47, -176.21 74.83, 73.76 -104.66, 7.86 282.59, 98.49 -68.99, -20.43 in-in in 8.442 Saltbr-in 2.922 HRD-in -73.71, -50.51 73.32, -9.3 in-in-in SNCiii in-in ActLoopNT-in 2.895 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.41, 162.37 APE9-dihe-na 129.79, -167.49 APE8-dihe-in -129.09, 132.1 APE8-rot-in 295.95 APE67-dihe-in -59.66, -23.23 -49.94, -47.34 APE12-dist-in 7.372 APE11-dist-in 10.575 APE10-dist-in 4.947 APE9-dist-in 3.545 Y288G,Q292A SEP241 SEP241 XRAY 1.4 0.13 0.165 A 310 289 0 0 0 0 [[82, 342]] 1.0 4xx9 AGC_PDPK1_HUMAN AGC 6.8e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4A07A O15530 75 359 556.0 ATP:500,AZ7:600,AZ7:700 ATPlike,Allosteric,Allosteric Active DFGin 6.655 14.752 BLAminus -135.35, -178.9 76.01, 72.4 -108.94, 8.63 286.31, 98.68 -64.37, -21.88 in-in in 8.621 Saltbr-in 2.919 HRD-in -76.19, -54.82 80.07, -12.14 in-in-in SNCiii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.16, 162.52 APE9-dihe-na 132.15, -164.48 APE8-dihe-in -133.89, 130.56 APE8-rot-in 295.87 APE67-dihe-in -62.13, -24.83 -47.31, -46.9 APE12-dist-in 7.322 APE11-dist-in 10.427 APE10-dist-in 4.998 APE9-dist-in 3.582 Y288G,Q292A SEP241 SEP241,CSS260 XRAY 1.85 0.161 0.2 A 311 285 0 0 0 0 [[82, 342]] 1.0 4a07 AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PRKACA KAPCA_HUMAN 4WB8A P17612 16 351 351.0 ATP:60401 ATPlike Active DFGin 5.684 14.414 BLAminus -121.45, -177.2 62.67, 77.75 -91.98, 24.58 268.87, 53.09 -58.34, -31.51 in-in in 8.913 Saltbr-in 2.759 HRD-in -95.2, -52.32 70.44, 11.38 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.85, 164.58 APE9-dihe-na 131.46, -156.38 APE8-dihe-in -129.55, 139.43 APE8-rot-in 297.11 APE67-dihe-in -60.54, -22.69 -52.03, -49.04 APE12-dist-in 8.098 APE11-dist-in 11.392 APE10-dist-in 5.827 APE9-dist-in 3.498 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.55 0.164 0.184 A 337 336 0 0 0 0 [[44, 298]] 1.0 4wb8 AGC_PRKACA_HUMAN AGC 4e-95 323.8 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB5A P17612 14 351 351.0 ATP:60401 ATPlike Active DFGin 5.6 14.452 BLAminus -123.05, 176.84 68.94, 80.02 -91.46, 24.86 270.2, 52.92 -60.74, -31.43 in-in in 9.03 Saltbr-in 2.715 HRD-in -92.12, -52.84 69.8, 13.37 in-in-in SNCiii in-in ActLoopNT-in 2.918 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.48, 163.75 APE9-dihe-na 132.31, -149.49 APE8-dihe-in -132.05, 134.14 APE8-rot-in 301.14 APE67-dihe-in -60.1, -21.12 -48.44, -50.23 APE12-dist-in 8.012 APE11-dist-in 11.4 APE10-dist-in 5.799 APE9-dist-in 3.567 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.641 0.165 0.196 A 350 338 0 0 0 0 [[44, 298]] 1.0 4wb5 AGC_PRKACA_HUMAN AGC 4.5e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6NO7E P17612 13 351 351.0 ATP:60403 ATPlike Inactive DFGin 6.934 14.165 BLAminus -118.71, 175.9 64.55, 75.01 -86.85, 19.7 273.68, 51.02 -43.49, -41.12 in-out in 9.419 Saltbr-out 5.456 HRD-in -91.66, -53.62 73.72, 11.47 out-in-in SNCoii in-in ActLoopNT-in 3.164 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.9, 150.23 APE9-dihe-na 149.21, -142.3 APE8-dihe-in -132.1, 131.95 APE8-rot-in 297.19 APE67-dihe-in -64.62, -25.64 -37.25, -53.79 APE12-dist-in 8.056 APE11-dist-in 10.984 APE10-dist-in 5.748 APE9-dist-in 3.216 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.55 0.259 0.269 E 350 339 0 0 0 0 [[44, 298]] 1.0 6no7 AGC_PRKACA_HUMAN AGC 4.5e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6NO7G P17612 15 351 351.0 ATP:60403 ATPlike Inactive DFGin 6.036 14.084 BLAminus -118.68, 176.55 65.34, 76.32 -85.78, 18.75 273.72, 51.07 -44.34, -41.82 in-out in 9.713 Saltbr-out 5.215 HRD-in -91.95, -53.38 74.11, 11.57 out-in-in SNCoii in-in ActLoopNT-in 3.302 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.42, 149.81 APE9-dihe-na 148.91, -142.4 APE8-dihe-in -132.18, 131.68 APE8-rot-in 297.12 APE67-dihe-in -64.98, -25.0 -37.42, -54.32 APE12-dist-in 7.668 APE11-dist-in 10.658 APE10-dist-in 5.553 APE9-dist-in 3.41 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.55 0.259 0.269 G 350 337 0 0 0 0 [[44, 298]] 1.0 6no7 AGC_PRKACA_HUMAN AGC 4.5e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB7A P17612 2 351 351.0 ATP:60501 ATPlike Active DFGin 5.445 14.649 BLAminus -119.06, -174.39 59.4, 77.28 -89.09, 26.42 267.74, 51.48 -60.48, -28.34 in-in in 8.87 Saltbr-in 2.769 HRD-in -93.55, -50.9 68.82, 8.95 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.63, 158.06 APE9-dihe-na 139.02, -156.91 APE8-dihe-in -126.94, 137.23 APE8-rot-in 299.54 APE67-dihe-in -64.26, -23.0 -50.4, -48.13 APE12-dist-in 8.18 APE11-dist-in 11.54 APE10-dist-in 5.955 APE9-dist-in 3.723 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.9 0.152 0.188 A 405 336 0 0 0 0 [[44, 298]] 1.0 4wb7 AGC_PRKACA_HUMAN AGC 7e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB7B P17612 2 351 351.0 ATP:60501 ATPlike Active DFGin 5.38 14.712 BLAminus -115.93, -176.79 62.38, 75.33 -88.91, 25.18 264.71, 51.71 -56.9, -30.26 in-in in 8.962 Saltbr-in 2.773 HRD-in -94.01, -50.55 67.24, 10.48 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.07, 161.39 APE9-dihe-na 132.31, -156.17 APE8-dihe-in -127.2, 138.18 APE8-rot-in 298.14 APE67-dihe-in -59.62, -23.37 -52.63, -48.78 APE12-dist-in 8.198 APE11-dist-in 11.563 APE10-dist-in 5.97 APE9-dist-in 3.642 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.9 0.152 0.188 B 405 336 0 0 0 0 [[44, 298]] 1.0 4wb7 AGC_PRKACA_HUMAN AGC 7e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6BYRA P17612 2 351 351.0 ATP:60501 ATPlike Active DFGin 5.626 14.616 BLAminus -128.29, 177.03 62.06, 86.64 -97.54, 28.59 271.87, 66.62 -63.2, -33.23 in-in in 8.808 Saltbr-in 3.196 HRD-in -87.43, -52.47 67.28, 5.18 in-in-in SNCiii in-in ActLoopNT-in 3.193 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.51, 153.24 APE9-dihe-na 149.32, -133.8 APE8-dihe-in -139.35, 133.91 APE8-rot-in 312.31 APE67-dihe-in -68.4, -6.95 -52.73, -48.25 APE12-dist-in 8.734 APE11-dist-in 11.076 APE10-dist-in 5.63 APE9-dist-in 3.491 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.661 0.203 0.249 A 405 336 0 0 0 0 [[44, 298]] 1.0 6byr AGC_PRKACA_HUMAN AGC 7e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6BYRC P17612 2 351 351.0 ATP:60501 ATPlike Active DFGin 5.679 14.34 BLAminus -129.89, 172.29 61.76, 74.25 -79.2, 34.93 281.69, 54.14 -61.8, -27.34 in-in in 8.733 Saltbr-in 2.498 HRD-in -93.13, -49.8 64.55, 7.44 in-in-in SNCiii in-in ActLoopNT-in 3.052 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.29, 161.94 APE9-dihe-na 130.51, -156.26 APE8-dihe-in -112.31, 134.09 APE8-rot-in 302.07 APE67-dihe-in -64.15, -16.52 -52.64, -41.39 APE12-dist-in 8.316 APE11-dist-in 11.106 APE10-dist-in 5.767 APE9-dist-in 3.618 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.661 0.203 0.249 C 405 336 0 0 0 0 [[44, 298]] 1.0 6byr AGC_PRKACA_HUMAN AGC 7e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 9EDCA P17612 14 351 351.0 ATP:60400 ATPlike Active DFGin 5.626 13.772 BLAminus -125.61, -173.52 60.53, 69.6 -81.59, 16.86 273.36, 51.23 -62.38, -30.28 in-in in 9.129 Saltbr-in 3.0 HRD-in -112.54, -46.7 65.17, 1.82 in-in-in SNCiii in-in ActLoopNT-in 3.14 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.87, 159.92 APE9-dihe-na 136.42, -156.18 APE8-dihe-in -101.13, 126.83 APE8-rot-in 299.98 APE67-dihe-in -84.76, -8.6 -60.74, -28.35 APE12-dist-in 7.999 APE11-dist-in 11.111 APE10-dist-in 5.797 APE9-dist-in 3.748 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 EM 4.18 999.0 999.0 A 350 338 0 0 0 0 [[44, 298]] 1.0 9edc AGC_PRKACA_HUMAN AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 9EDDA P17612 14 351 351.0 ATP:60400 ATPlike Inactive DFGin 7.642 15.48 BLAminus -131.38, -176.44 56.47, 73.0 -86.17, 32.62 269.53, 53.11 -62.17, -29.29 in-out in 9.617 Saltbr-out 3.947 HRD-in -100.83, -51.39 64.03, -2.2 out-out-out SNCooo out-out ActLoopNT-out 3.703 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.87, 141.16 APE9-dihe-na 150.41, -172.01 APE8-dihe-in -103.27, 147.74 APE8-rot-out 185.24 APE67-dihe-in -92.0, 3.92 -57.96, -27.57 APE12-dist-in 8.165 APE11-dist-in 11.275 APE10-dist-in 5.628 APE9-dist-in 4.227 None TPO198,SEP339 TPO198,SEP339 EM 6.3 999.0 999.0 A 350 338 0 0 0 0 [[44, 298]] 1.0 9edd AGC_PRKACA_HUMAN AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 9EDEA P17612 14 351 351.0 ATP:60400 ATPlike Inactive DFGin 6.692 15.188 BLAminus -131.57, -176.8 59.06, 65.59 -87.14, 28.49 267.05, 50.71 -66.29, -36.64 in-out in 9.922 Saltbr-out 4.682 HRD-in -115.21, -49.18 64.38, 4.15 out-out-out SNCooo out-out ActLoopNT-out 3.632 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -122.67, 141.1 APE9-dihe-na 158.89, -177.66 APE8-dihe-in -75.58, 154.98 APE8-rot-out 190.35 APE67-dihe-in -109.16, -25.21 -65.33, -8.36 APE12-dist-in 8.347 APE11-dist-in 11.783 APE10-dist-in 6.829 APE9-dist-in 4.918 None TPO198,SEP339 TPO198,SEP339 EM 5.9 999.0 999.0 A 350 338 0 0 0 0 [[44, 298]] 1.0 9ede AGC_PRKACA_HUMAN AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB6A P17612 14 351 351.0 ATP:60401 ATPlike Active DFGin 6.068 14.398 BLAminus -118.38, -169.49 51.77, 82.47 -95.61, 17.78 271.18, 55.73 -42.8, -37.29 in-in in 8.83 Saltbr-in 2.561 HRD-in -94.17, -52.18 74.17, 2.46 in-in-in SNCiii in-in ActLoopNT-in 2.948 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.55, 166.68 APE9-dihe-na 116.18, 128.45 APE8-dihe-in -46.62, 128.74 APE8-rot-in 303.5 APE67-dihe-in -58.01, -23.74 -49.09, -50.89 APE12-dist-in 8.046 APE11-dist-in 11.764 APE10-dist-in 6.243 APE9-dist-in 3.767 L206R SEP11,SEP140,TPO198 SEP11,SEP140,TPO198 XRAY 2.1 0.19 0.237 A 350 338 0 0 0 0 [[44, 298]] 1.0 4wb6 AGC_PRKACA_HUMAN AGC 8.6e-94 319.5 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB6B P17612 9 351 351.0 ATP:60401 ATPlike Active DFGin 5.872 14.073 BLAminus -117.82, -168.32 53.27, 78.35 -91.25, 29.34 274.97, 62.46 -60.26, -35.85 in-in in 8.687 Saltbr-in 2.75 HRD-in -101.62, -46.5 64.42, 3.48 in-in-in SNCiii in-in ActLoopNT-in 2.946 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.38, 164.15 APE9-dihe-na 120.83, 133.18 APE8-dihe-in -48.66, 125.41 APE8-rot-in 298.86 APE67-dihe-in -54.58, -37.6 -53.55, -42.52 APE12-dist-in 8.078 APE11-dist-in 11.617 APE10-dist-in 6.204 APE9-dist-in 3.822 L206R SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.1 0.19 0.237 B 350 343 0 0 0 0 [[44, 298]] 1.0 4wb6 AGC_PRKACA_HUMAN AGC 8.6e-94 319.5 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKCI KPCI_HUMAN 3A8WA P41743 249 588 596.0 ATP:60601 ATPlike Inactive DFGin 5.174 12.378 BLAminus -132.69, 170.49 67.34, 88.86 -96.11, 11.96 304.5, 130.94 -60.46, -20.34 in-out in 8.357 Saltbr-out 3.882 HRD-in -61.87, -57.79 75.89, -1.36 out-in-in SNCoii in-in ActLoopNT-in 2.771 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.32, 177.7 APE9-dihe-na 120.34, -178.18 APE8-dihe-in -99.49, 131.04 APE8-rot-in 301.47 APE67-dihe-in -55.52, -25.65 -39.88, -56.62 APE12-dist-in 8.769 APE11-dist-in 11.767 APE10-dist-in 6.259 APE9-dist-in 3.666 None TPO412,TPO564 TPO412,TPO564 XRAY 2.1 0.25 0.301 A 345 325 15 0 0 0 [[254, 522]] 1.0 3a8w AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 3A8WB P41743 249 588 596.0 ATP:60601 ATPlike Inactive DFGin 5.257 12.324 BLAminus -133.61, 172.63 64.84, 89.8 -97.52, 11.0 299.58, 138.75 -72.95, 35.24 in-out in 8.192 Saltbr-out 3.977 HRD-in -61.03, -56.18 70.75, 8.33 out-in-in SNCoii in-in ActLoopNT-in 2.997 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -171.82, 179.6 APE9-dihe-na 132.39, -163.28 APE8-dihe-in -113.8, 132.71 APE8-rot-in 303.74 APE67-dihe-in -61.94, -22.49 -35.42, -58.51 APE12-dist-in 8.76 APE11-dist-in 11.726 APE10-dist-in 6.539 APE9-dist-in 3.77 None TPO412,TPO564 TPO412,TPO564 XRAY 2.1 0.25 0.301 B 345 326 14 0 0 3 [[254, 522]] 1.0 3a8w AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKG1 KGP1_HUMAN 7T4TA Q13976 204 671 671.0 PCG:60701,ATP:60702 Allosteric,ATPlike Inactive DFGin 5.806 14.933 ABAminus -123.17, -29.2 -107.96, 118.17 -112.33, 30.1 285.53, 74.3 -67.24, -29.77 in-in in 9.557 Saltbr-in 3.38 HRD-in -86.67, -51.63 61.2, 10.68 in-in-in SNCiii in-in ActLoopNT-in 2.86 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -166.89, 164.61 APE9-dihe-na 124.7, -170.63 APE8-dihe-in -100.54, 134.31 APE8-rot-in 302.38 APE67-dihe-in -67.0, -27.98 -44.1, -43.89 APE12-dist-in 7.941 APE11-dist-in 10.713 APE10-dist-in 5.308 APE9-dist-in 3.712 None TPO517 TPO517 XRAY 2.08 0.19 0.221 A 469 453 0 0 0 0 [[360, 619]] 1.0 7t4t AGC_PRKG1_HUMAN AGC 6.4e-84 287.2 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7T4TB Q13976 204 671 671.0 PCG:60701,ATP:60702 Allosteric,ATPlike Inactive DFGin 5.8 14.811 ABAminus -121.38, -38.76 -100.76, 117.73 -112.4, 30.34 285.48, 73.71 -68.75, -29.12 in-in in 9.401 Saltbr-in 3.311 HRD-in -86.82, -51.68 61.52, 10.16 in-in-in SNCiii in-in ActLoopNT-in 2.853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.5, 164.27 APE9-dihe-na 124.32, -169.95 APE8-dihe-in -101.18, 134.26 APE8-rot-in 302.8 APE67-dihe-in -67.54, -26.94 -44.3, -44.01 APE12-dist-in 7.957 APE11-dist-in 10.757 APE10-dist-in 5.336 APE9-dist-in 3.717 None TPO517 TPO517 XRAY 2.08 0.19 0.221 B 469 453 0 0 0 0 [[360, 619]] 1.0 7t4t AGC_PRKG1_HUMAN AGC 6.4e-84 287.2 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
CAMK AURKA AURKA_HUMAN 5DNRA O14965 126 390 403.0 ATP:403 ATPlike Inactive DFGin 5.655 15.024 BLAminus -132.27, -179.72 60.78, 76.64 -90.12, 18.66 275.93, 74.44 -56.64, -35.89 in-in in 9.166 Saltbr-in 2.747 HRD-in -79.07, -53.73 71.53, 2.24 in-in-out SNCiio in-out ActLoopNT-in 2.945 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -125.56, 5.88 APE9-dihe-na -79.83, -178.97 APE8-dihe-in -49.83, 123.63 APE8-rot-in 300.84 APE67-dihe-in -48.83, -30.32 -94.71, -13.22 APE12-dist-in 9.348 APE11-dist-in 13.115 APE10-dist-out 15.947 APE9-dist-out 11.204 None TPO288 TPO288 XRAY 1.95 0.206 0.226 A 272 265 0 0 0 0 [[133, 383]] 1.0 5dnr CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DT3A O14965 127 390 403.0 ATP:403 ATPlike Inactive DFGin 5.731 15.047 BLAminus -138.47, 178.42 59.62, 78.35 -90.84, 24.83 281.41, 74.26 -61.06, -31.68 in-in in 9.451 Saltbr-in 2.917 HRD-in -69.42, -55.99 70.31, -3.53 in-in-out SNCiio in-out ActLoopNT-in 2.892 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -112.53, -5.85 APE9-dihe-na -110.59, -164.26 APE8-dihe-in -61.03, 149.68 APE8-rot-out 193.86 APE67-dihe-in -45.37, -39.19 -93.82, -1.33 APE12-dist-in 12.181 APE11-dist-in 10.015 APE10-dist-out 11.694 APE9-dist-out 10.487 None TPO287 TPO287 XRAY 2.33 0.21 0.243 A 273 264 0 0 0 0 [[133, 383]] 1.0 5dt3 CAMK_AURKA_HUMAN CAMK 6.5e-80 274.1 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DRDA O14965 127 390 403.0 ATP:402 ATPlike Inactive DFGin 6.179 15.49 BLAminus -124.75, -173.07 54.37, 73.03 -91.89, 14.82 276.39, 76.92 -60.47, -27.86 in-in in 9.094 Saltbr-in 2.712 HRD-in -86.49, -50.72 75.89, 5.8 in-in-out SNCiio in-out ActLoopNT-in 3.009 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -110.08 APE9-dihe-na -77.61, -136.85 APE8-dihe-in -63.84, 145.87 APE8-rot-out 199.39 APE67-dihe-in -52.56, -31.45 -96.52, -6.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.847 APE9-dist-out 10.623 T287A None None XRAY 2.13 0.209 0.262 A 273 259 5 0 0 5 [[133, 383]] 1.0 5drd CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 1OL6A O14965 128 388 403.0 ATP:1388 ATPlike Inactive DFGin 5.851 15.64 BLAminus -135.92, 178.5 52.45, 77.03 -92.23, 24.52 292.21, 75.73 -61.17, -14.48 in-out in 9.912 Saltbr-out 4.669 HRD-in -62.99, -55.9 71.29, 3.18 out-in-none SNCoin in-none ActLoopNT-in 3.099 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.06 APE8-rot-in 336.17 APE67-dihe-in -65.51, -21.75 -47.85, -55.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D274N None None XRAY 3.0 0.277 0.301 A 282 246 15 0 0 11 [[133, 383]] 1.0 1ol6 CAMK_AURKA_HUMAN CAMK 4.4e-79 271.4 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DN3A O14965 125 389 403.0 5DN:402,ATP:404 Allosteric,ATPlike Inactive DFGin 5.699 15.042 BLAminus -130.89, -174.42 55.28, 74.81 -88.98, 14.12 275.51, 75.93 -51.92, -35.15 in-in in 9.166 Saltbr-in 2.72 HRD-in -77.57, -53.05 71.13, 1.06 in-in-out SNCiio in-out ActLoopNT-in 2.956 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -118.61, -13.13 APE9-dihe-na -74.86, -176.69 APE8-dihe-in -54.45, 125.21 APE8-rot-in 310.73 APE67-dihe-in -44.24, -34.14 -96.33, -16.24 APE12-dist-in 9.435 APE11-dist-in 13.235 APE10-dist-out 15.667 APE9-dist-out 11.232 None TPO288 TPO288 XRAY 2.05 0.192 0.203 A 272 265 0 0 0 0 [[133, 383]] 1.0 5dn3 CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1EA O14965 127 388 403.0 T0X:401,ATP:403 Allosteric,ATPlike Inactive DFGin 5.798 14.807 BLAminus -150.0, 179.01 57.43, 76.53 -96.95, 20.99 278.49, 67.97 -56.09, -34.21 in-in in 9.191 Saltbr-in 2.847 HRD-in -74.81, -56.51 74.42, -5.07 in-in-out SNCiio in-out ActLoopNT-in 2.615 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -165.45, 99.75 APE9-dihe-na -118.34, -95.63 APE8-dihe-in -111.54, 127.78 APE8-rot-in 354.95 APE67-dihe-in -38.77, -37.51 -96.45, -21.24 APE12-dist-in 9.259 APE11-dist-in 13.544 APE10-dist-out 15.259 APE9-dist-out 10.896 None TPO288 TPO288 XRAY 2.798 0.176 0.239 A 272 262 0 0 0 0 [[133, 383]] 1.0 8c1e CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DT4A O14965 127 390 403.0 5DN:402,ATP:403 Allosteric,ATPlike Inactive DFGin 6.023 15.016 BLAminus -131.6, -179.1 56.58, 87.02 -103.91, 25.71 282.11, 78.42 -59.32, -42.3 in-in in 9.544 Saltbr-in 3.004 HRD-in -66.18, -52.21 66.74, -14.36 in-in-out SNCiio in-out ActLoopNT-in 2.944 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -57.69 APE9-dihe-na -89.02, -152.47 APE8-dihe-in -67.56, 141.58 APE8-rot-out 191.42 APE67-dihe-in -59.88, -41.29 -85.27, 2.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.159 APE9-dist-out 9.973 None None None XRAY 2.86 0.193 0.256 A 273 259 5 0 0 5 [[133, 383]] 1.0 5dt4 CAMK_AURKA_HUMAN CAMK 6.5e-80 274.1 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DOSA O14965 127 390 403.0 5DN:402,ATP:403 Allosteric,ATPlike Inactive DFGin 5.9 15.044 BLAminus -141.11, -178.41 56.44, 85.64 -101.51, 29.55 282.61, 75.97 -61.45, -42.65 in-in in 9.493 Saltbr-in 2.861 HRD-in -75.29, -42.25 59.65, -8.83 in-in-out SNCiio in-out ActLoopNT-in 3.042 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -79.83 APE9-dihe-na -91.08, -144.18 APE8-dihe-in -65.26, 123.97 APE8-rot-out 190.75 APE67-dihe-in -25.49, -64.25 -63.86, -31.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.033 APE9-dist-out 9.793 T287A None None XRAY 2.98 0.201 0.273 A 273 259 5 0 0 5 [[133, 383]] 1.0 5dos CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DR2A O14965 128 390 403.0 5E1:60401,ATP:60403 Allosteric,ATPlike Inactive DFGin 5.742 15.148 BLAminus -112.74, -178.24 59.1, 85.93 -103.74, 31.08 282.48, 80.94 -64.76, -39.96 in-in in 9.225 Saltbr-in 2.845 HRD-in -83.01, -54.44 78.2, -2.4 in-in-out SNCiio in-out ActLoopNT-in 2.871 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -117.43, 59.62 APE9-dihe-na -131.57, -163.05 APE8-dihe-in -74.95, 143.42 APE8-rot-out 161.96 APE67-dihe-in -60.88, -32.64 -91.05, 11.96 APE12-dist-in 12.526 APE11-dist-in 9.121 APE10-dist-out 12.632 APE9-dist-out 10.039 T287A None None XRAY 2.46 0.225 0.285 A 273 263 0 0 0 0 [[133, 383]] 1.0 5dr2 CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OBJA O14965 127 390 403.0 ATP:404,9QK:405 ATPlike,Allosteric Inactive DFGin 6.016 15.967 None -127.31, -156.34 57.9, -96.92 69.6, 25.6 277.68, 99.91 -74.82, -34.09 out-out out 10.869 Saltbr-out 3.975 HRD-in -84.35, -43.15 67.43, 1.86 out-in-out SNCoio in-out ActLoopNT-in 2.747 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -85.06 APE9-dihe-na -106.73, -153.17 APE8-dihe-in -86.88, 144.13 APE8-rot-in 279.73 APE67-dihe-in -52.07, -35.29 -66.02, -11.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.379 APE9-dist-out 10.199 None None None XRAY 2.901 0.215 0.245 A 272 260 4 0 0 4 [[133, 383]] 1.0 5obj CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK CAMK1 KCC1A_HUMAN 4FG7A Q14012 9 277 370.0 ATP:301 ATPlike None DFGin 6.733 14.558 BLAminus -139.66, 179.97 56.25, 83.23 -95.06, 23.76 286.93, 75.78 -57.64, -10.34 in-in in 9.756 Saltbr-in 2.988 HRD-in -66.62, -51.56 76.61, -3.11 in-in-none SNCiin in-none ActLoopNT-in 2.968 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 148.43 APE8-dihe-in -71.0, 118.39 APE8-rot-in 317.82 APE67-dihe-inflip 114.74, -42.57 -57.89, 141.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.149 None None None XRAY 2.7 0.221 0.246 A 293 250 19 0 0 8 [[20, 276]] 1.0 4fg7 CAMK_CAMK1_HUMAN CAMK 6.7e-97 329.7 1 256 256 161 162 163 165 167 49 66 70 138 140 139 141 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1 KCC1A_HUMAN 4FG9A Q14012 10 314 370.0 ATP:401 ATPlike Inactive DFGinter 6.372 9.923 None -94.72, -48.11 -72.17, 151.42 -111.14, 999.0 291.22, 108.3 999.0, 999.0 out-out out 13.251 Saltbr-out 11.213 HRD-in -52.69, -68.08 75.14, -19.91 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 133.2, -24.01 999.0, 22.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.211 0.249 A 320 278 27 0 0 18 [[20, 276]] 1.0 4fg9 CAMK_CAMK1_HUMAN CAMK 9.2e-97 329.5 1 256 256 161 162 163 165 167 49 66 70 138 140 139 141 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1 KCC1A_HUMAN 4FG9B Q14012 14 314 370.0 ATP:401 ATPlike Inactive DFGinter 6.287 9.324 None -97.62, -42.8 -76.25, 145.4 -105.57, 999.0 303.86, 102.8 999.0, 999.0 out-none out 16.899 Saltbr-none 999.0 HRD-in -42.26, -58.83 67.77, -17.08 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na -80.77, -34.84 APE9-dihe-na -79.39, -52.09 APE8-dihe-in -108.11, 99.06 APE8-rot-none 999.0 APE67-dihe-inflip 97.92, -38.15 -85.42, 136.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.53 None None None XRAY 2.4 0.211 0.249 B 320 279 22 0 0 10 [[20, 276]] 1.0 4fg9 CAMK_CAMK1_HUMAN CAMK 9.2e-97 329.5 1 256 256 161 162 163 165 167 49 66 70 138 140 139 141 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1 KCC1A_HUMAN 4FG8A Q14012 10 299 370.0 ATP:401 ATPlike Inactive None 999.0 999.0 None -88.48, -49.15 -70.71, 166.62 -106.58, 999.0 999.0, 999.0 999.0, 999.0 out-none out 14.285 Saltbr-none 999.0 HRD-in -68.76, -57.94 73.69, -12.61 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -41.56 APE8-rot-none 999.0 APE67-dihe-out 113.32, -70.06 -37.24, 130.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.198 0.248 A 315 263 27 0 0 17 [[20, 276]] 1.0 4fg8 CAMK_CAMK1_HUMAN CAMK 8.7e-97 329.4 1 256 256 161 162 163 165 167 49 66 70 138 140 139 141 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1 KCC1A_HUMAN 4FG8B Q14012 14 299 370.0 ATP:401 ATPlike Inactive None 999.0 999.0 None -101.4, -28.72 -75.18, 152.13 -127.71, -74.73 999.0, 999.0 -143.25, 999.0 out-none out 14.497 Saltbr-none 999.0 HRD-in -60.93, -60.01 82.66, -21.6 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaino APEdist_nnno APE10-dihe-na -81.34, -37.41 APE9-dihe-na -69.8, -52.82 APE8-dihe-in -110.8, 85.13 APE8-rot-none 999.0 APE67-dihe-out 122.52, -61.56 -92.65, 135.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.952 None None None XRAY 2.2 0.198 0.248 B 315 268 18 0 0 7 [[20, 276]] 1.0 4fg8 CAMK_CAMK1_HUMAN CAMK 8.7e-97 329.4 1 256 256 161 162 163 165 167 49 66 70 138 140 139 141 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK2A KCC2A_HUMAN 7UIRA Q9UQM7 7 274 478.0 ATP:302 ATPlike Active DFGin 6.045 15.107 BLAminus -137.0, 179.68 44.28, 101.28 -106.42, 24.78 295.79, 81.95 -53.14, -27.06 in-in in 9.85 Saltbr-in 3.466 HRD-in -74.22, -43.69 67.52, 3.92 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.48, 156.41 APE9-dihe-na 131.95, -156.1 APE8-dihe-in -122.09, 129.91 APE8-rot-in 298.28 APE67-dihe-in -55.12, -36.11 -51.43, -40.3 APE12-dist-in 10.333 APE11-dist-in 11.793 APE10-dist-in 6.056 APE9-dist-in 3.425 D135N,Q223K None None XRAY 3.1 0.234 0.274 A 268 268 0 0 0 0 [[13, 271]] 1.0 7uir CAMK_CAMK2A_HUMAN CAMK 9.3e-96 326.0 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 7UIRB Q9UQM7 7 273 478.0 ATP:301 ATPlike Active DFGin 6.093 14.463 BLAminus -136.84, -179.4 43.86, 99.82 -105.8, 24.57 296.99, 81.24 -56.04, -26.17 in-in in 9.403 Saltbr-in 3.027 HRD-in -74.93, -42.65 67.84, 3.24 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.86, 157.92 APE9-dihe-na 132.59, -155.55 APE8-dihe-in -122.09, 129.05 APE8-rot-in 298.73 APE67-dihe-in -54.7, -35.97 -51.63, -40.47 APE12-dist-in 10.303 APE11-dist-in 11.733 APE10-dist-in 5.989 APE9-dist-in 3.504 D135N,Q223K None None XRAY 3.1 0.234 0.274 B 268 261 6 0 0 0 [[13, 271]] 1.0 7uir CAMK_CAMK2A_HUMAN CAMK 9.3e-96 326.0 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 7UJPB Q9UQM7 7 273 478.0 ATP:301 ATPlike Active DFGin 6.942 14.313 BLAminus -133.64, 174.92 62.39, 75.15 -97.38, 27.07 283.14, 81.65 -64.42, -25.12 in-in in 8.558 Saltbr-in 2.783 HRD-in -76.01, -51.46 77.74, -9.31 in-in-in SNCiii in-in ActLoopNT-in 2.871 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.94, 139.06 APE9-dihe-na 146.74, -166.31 APE8-dihe-in -115.05, 124.1 APE8-rot-in 308.42 APE67-dihe-in -69.31, -14.12 -35.51, -54.36 APE12-dist-in 10.25 APE11-dist-in 11.592 APE10-dist-in 5.843 APE9-dist-in 3.572 D135N,Q223K None None XRAY 2.56 0.234 0.281 B 268 267 0 0 0 0 [[13, 271]] 1.0 7ujp CAMK_CAMK2A_HUMAN CAMK 9.3e-96 326.0 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 7UJTA Q9UQM7 7 274 478.0 ATP:301 ATPlike Inactive DFGin 5.793 15.871 BLAminus -136.06, 173.98 63.2, 83.03 -96.5, 26.66 288.93, 81.42 -61.86, -26.9 out-out out 10.354 Saltbr-out 4.962 HRD-in -68.86, -51.05 77.4, -6.28 out-in-in SNCoii in-in ActLoopNT-in 2.865 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.17, 142.76 APE9-dihe-na 138.67, -159.02 APE8-dihe-in -111.71, 119.97 APE8-rot-in 304.14 APE67-dihe-in -65.52, -19.91 -39.43, -49.22 APE12-dist-in 10.406 APE11-dist-in 11.791 APE10-dist-in 5.962 APE9-dist-in 3.835 D135N,Q223K None None XRAY 2.1 0.205 0.246 A 268 268 0 0 0 0 [[13, 271]] 1.0 7ujt CAMK_CAMK2A_HUMAN CAMK 9.3e-96 326.0 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK PHKG1 PHKG1_HUMAN 8Z5RC Q16816 12 383 387.0 ATP:401 ATPlike Inactive DFGin 6.216 15.79 BLAminus -134.62, -175.38 59.67, 63.56 -84.41, -0.54 270.17, 147.24 -63.63, -41.24 out-none out 10.415 Saltbr-none 999.0 HRD-in -97.74, -41.95 55.77, 14.53 none-out-in SNCnoi out-in ActLoopNT-out 3.722 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.82, 162.86 APE9-dihe-na 112.58, 179.42 APE8-dihe-in -65.24, 137.27 APE8-rot-in 278.19 APE67-dihe-in -93.32, 13.97 -60.86, -18.95 APE12-dist-in 9.617 APE11-dist-in 12.162 APE10-dist-in 7.279 APE9-dist-in 5.452 None None None EM 3.52 999.0 999.0 C 387 372 0 0 0 0 [[20, 288]] 1.0 8z5r CAMK_PHKG1_HUMAN CAMK 1.4e-85 292.7 1 256 256 167 168 169 171 173 49 74 78 147 149 148 150 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK PHKG1 PHKG1_HUMAN 8Z5TC Q16816 12 383 387.0 ATP:401 ATPlike Inactive DFGin 5.966 13.989 BLAminus -135.48, -169.66 58.09, 63.88 -81.9, 2.43 303.6, 100.06 -62.94, -40.27 out-none out 10.687 Saltbr-none 999.0 HRD-in -92.65, -46.31 62.21, 13.41 none-out-in SNCnoi out-in ActLoopNT-out 3.786 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.91, 163.41 APE9-dihe-na 112.45, -178.89 APE8-dihe-in -64.37, 134.79 APE8-rot-in 304.3 APE67-dihe-in -88.43, 6.38 -60.59, -20.91 APE12-dist-in 9.348 APE11-dist-in 12.089 APE10-dist-in 7.211 APE9-dist-in 5.344 None None None EM 3.74 999.0 999.0 C 387 372 0 0 0 0 [[20, 288]] 1.0 8z5t CAMK_PHKG1_HUMAN CAMK 1.4e-85 292.7 1 256 256 167 168 169 171 173 49 74 78 147 149 148 150 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK PHKG1 PHKG1_HUMAN 8Z5TG Q16816 12 383 387.0 ATP:401 ATPlike Inactive DFGin 6.211 16.35 BLAminus -138.41, -165.95 59.18, 62.46 -88.91, 3.24 271.18, 147.97 -59.75, -36.25 out-none out 10.64 Saltbr-none 999.0 HRD-in -91.86, -44.41 50.14, 19.86 none-out-out SNCnoo out-out ActLoopNT-out 3.788 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -170.81, -171.47 APE9-dihe-na 86.12, 176.52 APE8-dihe-in -63.45, 134.1 APE8-rot-in 318.38 APE67-dihe-in -94.57, 4.67 -60.84, -20.41 APE12-dist-in 10.099 APE11-dist-out 14.019 APE10-dist-out 9.046 APE9-dist-in 5.833 None None None EM 3.74 999.0 999.0 G 387 372 0 0 0 0 [[20, 288]] 1.0 8z5t CAMK_PHKG1_HUMAN CAMK 1.4e-85 292.7 1 256 256 167 168 169 171 173 49 74 78 147 149 148 150 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK PHKG1 PHKG1_HUMAN 8Z5TK Q16816 12 383 387.0 ATP:401 ATPlike Inactive DFGin 6.819 16.43 BLAminus -134.15, -169.32 57.8, 62.87 -86.64, 0.65 265.34, 130.05 -62.73, -39.71 out-none out 10.331 Saltbr-none 999.0 HRD-in -97.03, -55.84 67.06, 16.56 none-out-in SNCnoi out-in ActLoopNT-out 3.805 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.95, 163.43 APE9-dihe-na 106.51, -175.76 APE8-dihe-in -64.59, 130.37 APE8-rot-in 311.03 APE67-dihe-in -88.59, 5.57 -61.92, -16.15 APE12-dist-in 9.554 APE11-dist-in 12.273 APE10-dist-in 7.366 APE9-dist-in 5.268 None None None EM 3.74 999.0 999.0 K 387 372 0 0 0 0 [[20, 288]] 1.0 8z5t CAMK_PHKG1_HUMAN CAMK 1.4e-85 292.7 1 256 256 167 168 169 171 173 49 74 78 147 149 148 150 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK PHKG1 PHKG1_HUMAN 8Z5TO Q16816 12 383 387.0 ATP:401 ATPlike Inactive DFGin 6.326 15.79 BLAminus -126.17, -170.44 58.71, 63.18 -85.3, 0.59 276.38, 60.06 -63.17, -41.01 out-none out 10.539 Saltbr-none 999.0 HRD-in -82.25, -48.84 62.3, 10.36 none-out-in SNCnoi out-in ActLoopNT-out 3.696 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.09, 163.04 APE9-dihe-na 110.51, -176.12 APE8-dihe-in -65.19, 138.82 APE8-rot-in 315.28 APE67-dihe-in -94.37, 8.66 -62.65, -15.41 APE12-dist-in 9.558 APE11-dist-in 12.086 APE10-dist-in 7.195 APE9-dist-in 5.52 None None None EM 3.74 999.0 999.0 O 387 372 0 0 0 0 [[20, 288]] 1.0 8z5t CAMK_PHKG1_HUMAN CAMK 1.4e-85 292.7 1 256 256 167 168 169 171 173 49 74 78 147 149 148 150 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK STK17B ST17B_HUMAN 7Q7DA O94768 25 297 372.0 ATP:60401 ATPlike Inactive DFGin 5.979 13.981 BLAminus -131.01, 179.34 62.41, 83.11 -104.07, 20.6 289.75, 84.41 -62.74, -20.86 in-in in 9.348 Saltbr-in 3.538 HRD-in -65.32, -50.49 69.46, 8.5 in-in-out SNCiio in-out ActLoopNT-in 3.058 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -156.23, 8.1 APE9-dihe-na -82.21, -176.47 APE8-dihe-in -53.98, 115.12 APE8-rot-in 320.45 APE67-dihe-in -72.35, -13.63 -52.11, -32.33 APE12-dist-in 7.748 APE11-dist-in 12.291 APE10-dist-out 11.219 APE9-dist-out 7.597 None None None XRAY 2.6 0.196 0.235 A 327 273 0 0 0 0 [[32, 293]] 1.0 7q7d CAMK_STK17B_HUMAN CAMK 1.4e-81 279.8 4 256 253 178 179 180 182 184 62 80 84 155 157 156 158 217 205 200 199 198 197 196 195 194 111 Serine/threonine-protein kinase 17B
CAMK STK17B ST17B_HUMAN 7Q7EA O94768 25 297 372.0 ATP:60401 ATPlike Inactive DFGin 5.806 13.997 BLAminus -136.48, 179.08 63.28, 89.42 -111.5, 27.32 288.43, 87.78 -70.0, -15.51 in-in in 9.313 Saltbr-in 3.117 HRD-in -75.17, -47.59 66.91, 14.25 in-in-out SNCiio in-out ActLoopNT-in 3.4 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -119.2, -9.71 APE9-dihe-na -66.55, 174.56 APE8-dihe-in -49.86, 121.22 APE8-rot-in 313.96 APE67-dihe-in -70.36, -7.82 -52.35, -34.48 APE12-dist-in 7.378 APE11-dist-in 12.111 APE10-dist-out 10.79 APE9-dist-out 7.473 None None None XRAY 2.85 0.191 0.239 A 327 273 0 0 0 0 [[32, 293]] 1.0 7q7e CAMK_STK17B_HUMAN CAMK 1.4e-81 279.8 4 256 253 178 179 180 182 184 62 80 84 155 157 156 158 217 205 200 199 198 197 196 195 194 111 Serine/threonine-protein kinase 17B
CK1 TTBK1 TTBK1_HUMAN 4BTJB Q5TCY1 21 313 1321.0 ATP:61338 ATPlike Active DFGin 5.352 12.718 BLAminus -122.53, 168.88 60.17, 88.3 -98.51, 13.52 307.1, 115.33 -64.8, -32.06 in-in in 7.148 Saltbr-in 2.816 HRD-in -78.94, -51.75 72.7, -0.47 in-in-in SNCiii in-in ActLoopNT-in 2.748 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.82, -14.94 APE9-dihe-na -62.51, -161.18 APE8-dihe-in -100.71, 125.28 APE8-rot-in 309.68 APE67-dihe-in -55.66, -43.07 -52.23, -50.62 APE12-dist-in 11.078 APE11-dist-in 10.816 APE10-dist-in 6.463 APE9-dist-in 4.328 None None None XRAY 2.16 0.179 0.197 B 337 293 0 0 0 0 [[34, 295]] 1.0 4btj CK1_TTBK1_HUMAN CK1 5.7e-105 356.4 1 262 262 175 176 177 179 181 63 77 81 151 153 152 154 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
CMGC CDK2 CDK2_HUMAN 4EOOA P24941 1 297 298.0 ATP:60302 ATPlike Inactive DFGin 6.651 15.121 BLAminus -137.3, -178.29 51.93, 74.48 -88.78, 23.73 283.58, 71.37 -66.89, -17.34 in-in in 8.754 Saltbr-in 2.774 HRD-in -82.21, -55.51 72.81, 10.91 in-in-out SNCiio in-out ActLoopNT-in 2.878 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.74, 151.81 APE9-dihe-na 71.22, 125.56 APE8-dihe-in -63.52, 145.17 APE8-rot-out 106.26 APE67-dihe-in -59.56, -25.92 -46.12, -48.45 APE12-dist-in 12.954 APE11-dist-in 10.307 APE10-dist-in 7.133 APE9-dist-in 3.247 Q131E TPO160 TPO160 XRAY 2.1 0.216 0.253 A 299 293 4 0 0 0 [[4, 286]] 1.0 4eoo CMGC_CDK2_HUMAN CMGC 3.7e-90 308.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOOC P24941 1 296 298.0 ATP:60301 ATPlike Inactive DFGin 6.441 15.255 BLAminus -132.94, -176.35 50.17, 74.17 -84.23, 27.4 283.88, 71.77 -62.65, -24.02 in-in in 8.772 Saltbr-in 2.725 HRD-in -84.21, -52.66 66.89, 14.22 in-in-out SNCiio in-out ActLoopNT-in 2.986 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -124.67, 158.22 APE9-dihe-na 65.39, 129.96 APE8-dihe-in -70.44, 149.36 APE8-rot-out 84.06 APE67-dihe-in -53.86, -24.11 -49.71, -53.55 APE12-dist-in 12.807 APE11-dist-in 10.003 APE10-dist-in 6.75 APE9-dist-in 3.286 Q131E TPO160 TPO160 XRAY 2.1 0.216 0.253 C 299 296 0 0 0 0 [[4, 286]] 1.0 4eoo CMGC_CDK2_HUMAN CMGC 3.7e-90 308.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOMA P24941 1 297 298.0 ATP:60301 ATPlike Inactive DFGin 6.766 15.173 BLAminus -135.89, -179.95 56.75, 76.33 -93.68, 18.3 281.75, 72.51 -65.02, -17.06 in-in in 8.656 Saltbr-in 2.954 HRD-in -79.7, -58.84 74.79, 7.53 in-in-out SNCiio in-out ActLoopNT-in 2.855 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na 71.17, 129.47 APE9-dihe-na 73.49, 129.68 APE8-dihe-in -66.58, 140.55 APE8-rot-out 117.21 APE67-dihe-in -54.12, -27.93 -44.4, -51.19 APE12-dist-in 13.269 APE11-dist-in 9.227 APE10-dist-in 7.153 APE9-dist-in 3.259 H84S,Q85M,Q131E TPO160 TPO160 XRAY 2.1 0.21 0.243 A 301 295 2 0 0 0 [[4, 286]] 1.0 4eom CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOMC P24941 1 296 298.0 ATP:60301 ATPlike Inactive DFGin 6.612 15.121 BLAminus -134.3, 179.46 56.9, 73.57 -89.28, 27.08 288.28, 71.72 -61.57, -29.46 in-in in 8.464 Saltbr-in 2.764 HRD-in -79.86, -55.51 70.21, 14.99 in-in-out SNCiio in-out ActLoopNT-in 2.988 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.3, 158.32 APE9-dihe-na 61.45, 125.91 APE8-dihe-in -61.76, 140.91 APE8-rot-out 72.97 APE67-dihe-in -49.53, -25.94 -36.27, -61.03 APE12-dist-in 12.846 APE11-dist-in 9.68 APE10-dist-in 6.944 APE9-dist-in 3.36 H84S,Q85M,Q131E TPO160 TPO160 XRAY 2.1 0.21 0.243 C 301 272 24 0 0 0 [[4, 286]] 1.0 4eom CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1FINA P24941 1 298 298.0 ATP:299 ATPlike Inactive DFGin 6.269 15.397 BLAminus -145.66, 175.42 60.17, 70.41 -88.62, 22.31 287.3, 65.31 -62.81, -23.63 in-in in 8.878 Saltbr-in 3.066 HRD-in -75.81, -52.6 66.76, 11.52 in-in-out SNCiio in-out ActLoopNT-in 2.848 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -159.69, 149.42 APE9-dihe-na -56.35, 161.85 APE8-dihe-in -65.27, 149.59 APE8-rot-out 191.08 APE67-dihe-in -48.48, -30.03 -41.87, -56.23 APE12-dist-in 10.428 APE11-dist-out 5.924 APE10-dist-out 8.991 APE9-dist-in 4.147 None None None XRAY 2.3 0.208 999.0 A 298 298 0 0 0 0 [[4, 286]] 1.0 1fin CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1FINC P24941 1 298 298.0 ATP:299 ATPlike Inactive DFGin 6.329 16.114 BLAminus -126.26, 177.09 60.06, 80.37 -100.41, 24.94 280.63, 71.46 -64.88, -37.23 in-in in 9.234 Saltbr-in 3.016 HRD-in -71.64, -45.48 67.73, -0.73 in-in-out SNCiio in-out ActLoopNT-in 2.657 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -100.08, 164.84 APE9-dihe-na -64.11, 161.66 APE8-dihe-in -58.82, 141.21 APE8-rot-in 296.75 APE67-dihe-in -52.5, -36.66 -49.82, -46.41 APE12-dist-in 10.426 APE11-dist-out 6.239 APE10-dist-out 9.723 APE9-dist-in 3.907 None None None XRAY 2.3 0.208 999.0 C 298 298 0 0 0 0 [[4, 286]] 1.0 1fin CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1FQ1B P24941 1 296 298.0 ATP:381 ATPlike Inactive DFGin 6.774 15.622 BLAminus -151.24, -169.54 37.68, 67.63 -81.17, 26.85 274.26, 50.62 -66.75, -18.36 in-out in 9.807 Saltbr-out 3.73 HRD-in -76.57, -60.94 80.93, -25.61 out-in-out SNCoio in-out ActLoopNT-in 2.61 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oioo APE10-dihe-na -104.21, 92.46 APE9-dihe-na -93.56, -175.8 APE8-dihe-out -64.18, -46.74 APE8-rot-in 317.22 APE67-dihe-out -56.53, -27.84 69.72, -12.02 APE12-dist-out 16.113 APE11-dist-in 11.902 APE10-dist-out 15.594 APE9-dist-out 10.131 None TPO160 TPO160 XRAY 3.0 0.235 0.313 B 298 296 0 0 0 0 [[4, 286]] 1.0 1fq1 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1JSTA P24941 1 298 298.0 ATP:300 ATPlike Active DFGin 6.427 15.464 BLAminus -139.88, 179.46 48.93, 78.76 -92.24, 30.29 284.11, 71.63 -70.08, -30.4 in-in in 8.717 Saltbr-in 2.757 HRD-in -78.76, -47.67 60.69, 17.81 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.53, 164.64 APE9-dihe-na 80.72, 135.16 APE8-dihe-in -62.71, 138.95 APE8-rot-in 293.52 APE67-dihe-in -51.22, -30.94 -33.79, -62.16 APE12-dist-in 13.121 APE11-dist-in 11.934 APE10-dist-in 7.067 APE9-dist-in 3.277 None TPO160 TPO160 XRAY 2.6 0.2 999.0 A 298 298 0 0 0 0 [[4, 286]] 1.0 1jst CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1JSTC P24941 1 298 298.0 ATP:300 ATPlike Active DFGin 6.225 15.133 BLAminus -133.76, 179.75 53.92, 86.29 -100.05, 15.63 279.16, 71.07 -59.91, -21.96 in-in in 8.679 Saltbr-in 2.947 HRD-in -76.84, -49.3 61.77, 13.04 in-in-in SNCiii in-in ActLoopNT-in 2.701 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.31, -163.7 APE9-dihe-na 66.67, 148.27 APE8-dihe-in -72.61, 126.34 APE8-rot-in 301.65 APE67-dihe-in -51.49, -27.24 -26.21, -64.21 APE12-dist-in 13.412 APE11-dist-in 12.741 APE10-dist-in 6.942 APE9-dist-in 3.204 None TPO160 TPO160 XRAY 2.6 0.2 999.0 C 298 298 0 0 0 0 [[4, 286]] 1.0 1jst CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2CJMA P24941 1 292 298.0 ATP:1294 ATPlike Active DFGin 6.412 15.477 BLAminus -133.49, 174.28 59.08, 80.72 -93.05, 17.33 280.25, 71.88 -51.1, -37.87 in-in in 8.875 Saltbr-in 3.027 HRD-in -83.77, -55.33 74.52, 15.85 in-in-in SNCiii in-in ActLoopNT-in 2.796 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.97, -48.89 APE9-dihe-na -98.03, 148.0 APE8-dihe-in -53.4, 136.55 APE8-rot-in 296.67 APE67-dihe-in -56.28, -31.52 -52.78, -45.83 APE12-dist-in 13.329 APE11-dist-in 10.553 APE10-dist-in 7.18 APE9-dist-in 3.464 None PTR15,TPO160 PTR15,TPO160 XRAY 2.3 0.204 0.265 A 298 287 5 0 0 0 [[4, 286]] 1.0 2cjm CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2CJMC P24941 1 297 298.0 ATP:1298 ATPlike Active DFGin 6.446 15.389 BLAminus -136.23, -173.15 48.46, 78.84 -90.01, 21.15 280.3, 74.36 -53.78, -24.47 in-in in 8.957 Saltbr-in 2.575 HRD-in -82.67, -49.67 67.53, 9.26 in-in-in SNCiii in-in ActLoopNT-in 2.979 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.3, -72.35 APE9-dihe-na -81.21, 139.76 APE8-dihe-in -48.67, 128.86 APE8-rot-in 299.02 APE67-dihe-in -54.58, -22.4 -47.31, -51.92 APE12-dist-in 13.068 APE11-dist-in 10.808 APE10-dist-in 7.009 APE9-dist-in 3.58 None PTR15,TPO160 PTR15,TPO160 XRAY 2.3 0.204 0.265 C 298 297 0 0 0 0 [[4, 286]] 1.0 2cjm CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1GY3A P24941 1 296 298.0 ATP:1297 ATPlike Active DFGin 6.711 15.739 BLAminus -148.85, -171.85 44.28, 78.14 -91.55, 12.53 280.84, 73.84 -49.56, -35.56 in-in in 8.826 Saltbr-in 2.87 HRD-in -78.88, -56.55 74.04, 15.78 in-in-in SNCiii in-in ActLoopNT-in 3.129 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.01, 152.98 APE9-dihe-na 75.99, 139.26 APE8-dihe-in -71.28, 139.34 APE8-rot-in 297.69 APE67-dihe-in -59.44, -30.42 -47.65, -49.93 APE12-dist-in 13.156 APE11-dist-in 10.678 APE10-dist-in 7.643 APE9-dist-in 3.395 None TPO160 TPO160 XRAY 2.7 0.25 0.313 A 299 296 0 0 0 0 [[4, 286]] 1.0 1gy3 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1GY3C P24941 1 296 298.0 ATP:1298 ATPlike Active DFGin 6.824 15.376 BLAminus -159.42, -172.39 46.56, 69.8 -88.25, 18.8 278.1, 68.22 -63.28, -3.45 in-in in 8.61 Saltbr-in 3.316 HRD-in -72.89, -69.46 86.12, 7.32 in-in-in SNCiii in-in ActLoopNT-in 2.794 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.99, 145.31 APE9-dihe-na 77.28, 144.74 APE8-dihe-in -75.96, 137.92 APE8-rot-in 277.1 APE67-dihe-in -64.24, -30.46 -41.97, -49.4 APE12-dist-in 13.195 APE11-dist-in 10.636 APE10-dist-in 7.772 APE9-dist-in 3.212 None TPO160 TPO160 XRAY 2.7 0.25 0.313 C 299 296 0 0 0 0 [[4, 286]] 1.0 1gy3 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1QMZA P24941 1 296 298.0 ATP:60381 ATPlike Active DFGin 6.424 15.17 BLAminus -146.26, -172.65 47.53, 78.45 -93.94, 24.34 280.23, 76.95 -74.2, -4.32 in-in in 8.74 Saltbr-in 2.663 HRD-in -79.61, -61.2 70.52, 19.43 in-in-in SNCiii in-in ActLoopNT-in 2.981 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.31, 152.76 APE9-dihe-na 72.53, 130.75 APE8-dihe-in -60.65, 130.8 APE8-rot-in 293.88 APE67-dihe-in -60.7, -26.37 -33.48, -54.72 APE12-dist-in 13.02 APE11-dist-in 10.095 APE10-dist-in 7.17 APE9-dist-in 3.235 None TPO160 TPO160 XRAY 2.2 0.22 0.28 A 299 296 0 0 0 0 [[4, 286]] 1.0 1qmz CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1QMZC P24941 1 296 298.0 ATP:60381 ATPlike Active DFGin 6.512 15.134 BLAminus -147.61, -169.98 41.15, 80.53 -95.52, 25.6 283.09, 73.82 -79.03, -0.31 in-in in 8.74 Saltbr-in 2.54 HRD-in -75.88, -57.22 71.34, 18.39 in-in-in SNCiii in-in ActLoopNT-in 2.993 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.04, 148.92 APE9-dihe-na 73.46, 130.58 APE8-dihe-in -61.75, 132.61 APE8-rot-in 296.97 APE67-dihe-in -70.09, -17.52 -37.4, -48.3 APE12-dist-in 12.947 APE11-dist-in 10.103 APE10-dist-in 7.19 APE9-dist-in 3.234 None TPO160 TPO160 XRAY 2.2 0.22 0.28 C 299 296 0 0 0 0 [[4, 286]] 1.0 1qmz CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2CCHA P24941 1 296 298.0 ATP:61297 ATPlike Active DFGin 6.648 15.496 BLAminus -138.14, 178.31 65.58, 62.78 -86.23, 16.74 281.6, 70.81 -63.75, -23.41 in-in in 8.795 Saltbr-in 2.828 HRD-in -78.21, -56.44 71.04, 15.24 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.4, 152.64 APE9-dihe-na 69.68, 132.94 APE8-dihe-in -57.07, 137.05 APE8-rot-in 294.63 APE67-dihe-in -60.03, -20.02 -46.03, -52.89 APE12-dist-in 13.198 APE11-dist-in 10.36 APE10-dist-in 7.208 APE9-dist-in 3.286 None TPO160 TPO160 XRAY 1.7 0.15 0.182 A 299 296 0 0 0 0 [[4, 286]] 1.0 2cch CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2CCHC P24941 1 296 298.0 ATP:61297 ATPlike Active DFGin 6.477 15.382 BLAminus -137.71, -178.58 51.07, 78.61 -96.17, 22.01 279.1, 72.77 -65.43, -25.94 in-in in 8.653 Saltbr-in 2.719 HRD-in -81.45, -53.09 63.51, 17.55 in-in-in SNCiii in-in ActLoopNT-in 2.886 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.56, 136.55 APE9-dihe-na 76.27, 128.23 APE8-dihe-in -59.37, 134.24 APE8-rot-in 303.33 APE67-dihe-in -63.22, -26.6 -41.45, -49.27 APE12-dist-in 12.866 APE11-dist-in 10.056 APE10-dist-in 7.377 APE9-dist-in 3.26 None TPO160 TPO160 XRAY 1.7 0.15 0.182 C 299 296 0 0 0 0 [[4, 286]] 1.0 2cch CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2CCIA P24941 1 296 298.0 ATP:61297 ATPlike Active DFGin 6.459 15.372 BLAminus -128.71, -173.86 48.01, 81.43 -98.73, 25.24 282.02, 74.31 -66.86, -20.71 in-in in 8.902 Saltbr-in 3.076 HRD-in -75.27, -47.91 58.22, 13.15 in-in-in SNCiii in-in ActLoopNT-in 2.892 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.39, 140.99 APE9-dihe-na 76.14, 131.3 APE8-dihe-in -63.2, 133.24 APE8-rot-in 305.53 APE67-dihe-in -53.35, -21.65 -35.23, -63.18 APE12-dist-in 12.958 APE11-dist-in 10.323 APE10-dist-in 7.246 APE9-dist-in 3.291 None TPO160 TPO160 XRAY 2.7 0.264 0.321 A 299 296 0 0 0 0 [[4, 286]] 1.0 2cci CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2CCIC P24941 1 296 298.0 ATP:61297 ATPlike Active DFGin 6.232 15.382 BLAminus -129.31, 167.15 64.1, 86.76 -100.18, 28.53 276.86, 72.85 -63.26, -37.36 in-in in 8.551 Saltbr-in 2.666 HRD-in -73.66, -47.99 63.69, 10.4 in-in-in SNCiii in-in ActLoopNT-in 3.064 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.2, 138.6 APE9-dihe-na 71.13, 137.9 APE8-dihe-in -63.98, 129.66 APE8-rot-in 301.4 APE67-dihe-in -61.96, -9.78 -29.15, -60.17 APE12-dist-in 12.753 APE11-dist-in 9.767 APE10-dist-in 7.42 APE9-dist-in 3.234 None TPO160 TPO160 XRAY 2.7 0.264 0.321 C 299 296 0 0 0 0 [[4, 286]] 1.0 2cci CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOQA P24941 1 297 298.0 ATP:60301 ATPlike Inactive DFGin 6.603 15.258 BLAminus -136.2, -179.04 55.17, 77.3 -91.43, 19.33 282.26, 72.55 -64.29, -18.87 in-in in 8.786 Saltbr-in 2.845 HRD-in -79.78, -53.17 69.74, 9.41 in-in-out SNCiio in-out ActLoopNT-in 2.906 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na 62.26, 128.16 APE9-dihe-na 76.05, 127.33 APE8-dihe-in -62.55, 137.94 APE8-rot-out 115.71 APE67-dihe-in -58.94, -23.33 -43.56, -48.15 APE12-dist-in 13.361 APE11-dist-in 9.158 APE10-dist-in 7.177 APE9-dist-in 3.246 None TPO160 TPO160 XRAY 2.15 0.201 0.234 A 301 294 3 0 0 0 [[4, 286]] 1.0 4eoq CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOQC P24941 1 296 298.0 ATP:60301 ATPlike Inactive DFGin 6.583 15.249 BLAminus -140.92, -177.14 51.0, 72.99 -85.26, 24.65 284.32, 71.69 -63.95, -27.55 in-in in 8.649 Saltbr-in 2.713 HRD-in -79.85, -57.3 73.26, 6.95 in-in-out SNCiio in-out ActLoopNT-in 2.949 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -135.95, 149.43 APE9-dihe-na 70.01, 126.65 APE8-dihe-in -62.68, 144.35 APE8-rot-out 86.91 APE67-dihe-in -60.3, -23.97 -41.77, -51.35 APE12-dist-in 12.923 APE11-dist-in 9.988 APE10-dist-in 7.055 APE9-dist-in 3.18 None TPO160 TPO160 XRAY 2.15 0.201 0.234 C 301 272 24 0 0 0 [[4, 286]] 1.0 4eoq CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOJA P24941 1 298 298.0 ATP:60301 ATPlike Inactive DFGin 6.671 15.377 BLAminus -134.08, 177.58 53.89, 78.08 -94.34, 17.78 277.91, 75.6 -65.2, -18.6 in-in in 8.642 Saltbr-in 2.923 HRD-in -77.88, -54.19 68.96, 13.72 in-in-out SNCiio in-out ActLoopNT-in 2.952 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -80.75, 158.76 APE9-dihe-na 76.84, 131.84 APE8-dihe-in -62.19, 141.78 APE8-rot-out 119.83 APE67-dihe-in -58.91, -24.4 -48.51, -47.68 APE12-dist-in 13.309 APE11-dist-in 9.149 APE10-dist-in 7.333 APE9-dist-in 3.214 H84S,Q85M,K89D TPO160 TPO160 XRAY 1.65 0.197 0.215 A 302 294 4 0 0 0 [[4, 286]] 1.0 4eoj CMGC_CDK2_HUMAN CMGC 2.1e-89 306.1 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOJC P24941 1 296 298.0 ATP:60301 ATPlike Inactive DFGin 6.604 15.375 BLAminus -136.46, -177.75 51.71, 75.47 -89.77, 20.18 280.05, 73.98 -59.21, -28.77 in-in in 8.59 Saltbr-in 2.63 HRD-in -79.08, -54.75 70.82, 10.21 in-in-out SNCiio in-out ActLoopNT-in 2.918 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.67, 155.4 APE9-dihe-na 67.15, 126.49 APE8-dihe-in -61.14, 141.64 APE8-rot-out 49.99 APE67-dihe-in -62.84, -21.66 -42.97, -49.5 APE12-dist-in 12.897 APE11-dist-in 9.826 APE10-dist-in 6.834 APE9-dist-in 3.184 H84S,Q85M,K89D TPO160 TPO160 XRAY 1.65 0.197 0.215 C 302 279 17 0 0 0 [[4, 286]] 1.0 4eoj CMGC_CDK2_HUMAN CMGC 2.1e-89 306.1 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1HCKA P24941 1 298 298.0 ATP:400 ATPlike Inactive DFGin 10.521 18.374 BLBtrans -101.64, 156.72 59.01, 28.24 -65.02, 120.2 217.92, 114.75 87.03, -4.22 out-out out 14.886 Saltbr-out 16.602 HRD-in -89.06, -54.55 70.31, -1.71 out-out-out SNCooo out-out ActLoopNT-out 5.768 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -59.61, 130.9 APE9-dihe-na -79.22, 142.0 APE8-dihe-in -76.12, 133.01 APE8-rot-out 180.79 APE67-dihe-in -48.4, -27.96 -101.36, -7.62 APE12-dist-out 20.077 APE11-dist-out 17.599 APE10-dist-out 19.471 APE9-dist-out 11.031 None None None XRAY 1.9 0.185 0.272 A 298 294 4 0 0 0 [[4, 286]] 1.0 1hck CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 8FP5A P24941 2 298 298.0 ATP:302 ATPlike Inactive DFGin 10.376 18.32 BLBtrans -107.51, 151.36 65.27, 30.62 -67.28, 128.54 213.84, 133.39 81.57, 1.02 out-out out 15.796 Saltbr-out 15.873 HRD-in -85.24, -57.92 82.57, -13.18 out-out-out SNCooo out-out ActLoopNT-out 5.893 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -82.36, 136.98 APE9-dihe-na -71.53, 131.08 APE8-dihe-in -77.4, 124.67 APE8-rot-in 308.71 APE67-dihe-in -62.7, -24.4 -97.59, -2.61 APE12-dist-out 20.412 APE11-dist-out 17.362 APE10-dist-out 19.075 APE9-dist-out 10.919 None None None XRAY 1.7 0.196 0.23 A 298 288 9 0 0 0 [[4, 286]] 1.0 8fp5 CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1B38A P24941 1 298 298.0 ATP:60381 ATPlike Inactive DFGin 10.197 18.302 BLBtrans -95.65, 156.45 60.68, 25.9 -58.03, 132.69 221.26, 95.46 85.91, -14.49 out-out out 15.154 Saltbr-out 16.064 HRD-in -76.6, -58.97 89.85, -20.78 out-out-out SNCooo out-out ActLoopNT-out 6.207 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -77.95, 142.89 APE9-dihe-na -75.18, 129.36 APE8-dihe-in -71.98, 129.31 APE8-rot-out 193.64 APE67-dihe-in -51.99, -31.61 -101.67, -5.99 APE12-dist-out 19.553 APE11-dist-out 17.458 APE10-dist-out 18.673 APE9-dist-out 10.568 None None None XRAY 2.0 0.18 0.25 A 299 290 8 0 0 0 [[4, 286]] 1.0 1b38 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1B39A P24941 1 298 298.0 ATP:60381 ATPlike Inactive DFGin 10.534 18.343 BLBtrans -101.01, 147.7 73.19, 23.92 -63.93, 137.58 224.37, 103.76 85.74, -27.62 out-out out 15.412 Saltbr-out 16.029 HRD-in -84.44, -53.29 77.56, -15.37 out-out-out SNCooo out-out ActLoopNT-out 5.843 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -101.65, 122.32 APE9-dihe-na -57.75, 145.92 APE8-dihe-in -67.9, 142.03 APE8-rot-in 290.02 APE67-dihe-in -56.66, -23.98 -105.17, -10.65 APE12-dist-out 20.463 APE11-dist-out 17.183 APE10-dist-out 18.313 APE9-dist-out 9.98 None None None XRAY 2.1 0.2 0.27 A 299 290 8 0 0 0 [[4, 286]] 1.0 1b39 CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK7 CDK7_HUMAN 1UA2A P50613 13 311 346.0 ATP:381 ATPlike Inactive DFGin 3.838 15.074 None -72.36, 176.54 -63.29, 129.93 -58.5, 61.34 34.11, 88.78 62.95, -115.18 out-out out 13.014 Saltbr-out 13.633 HRD-out -71.94, 127.86 -111.75, 17.16 out-out-out SNCooo out-out ActLoopNT-out 10.781 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -60.17, 155.77 APE9-dihe-na -94.04, -36.01 APE8-dihe-out 80.52, 83.34 APE8-rot-in 310.15 APE67-dihe-in -70.12, 0.07 -111.89, 13.44 APE12-dist-out 21.608 APE11-dist-out 18.745 APE10-dist-out 20.457 APE9-dist-out 13.019 None TPO170 TPO170 XRAY 3.02 0.217 0.288 A 346 287 13 0 0 0 [[12, 295]] 1.0 1ua2 CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 1UA2B P50613 13 311 346.0 ATP:382 ATPlike Inactive DFGin 4.075 14.483 None -83.42, -165.13 -43.25, 135.34 -79.47, 27.14 49.47, 35.58 128.26, -117.59 out-out out 13.208 Saltbr-out 11.182 HRD-out -90.35, 54.77 -58.64, -3.2 out-out-out SNCooo out-out ActLoopNT-out 10.755 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -59.37, 128.97 APE9-dihe-na -70.17, -103.62 APE8-dihe-out 114.41, 132.59 APE8-rot-out 86.06 APE67-dihe-in -64.71, -6.03 -138.86, 19.47 APE12-dist-out 21.356 APE11-dist-out 17.939 APE10-dist-out 20.116 APE9-dist-out 13.119 None TPO170 TPO170 XRAY 3.02 0.217 0.288 B 346 287 13 0 0 0 [[12, 295]] 1.0 1ua2 CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 1UA2C P50613 13 311 346.0 ATP:383 ATPlike Inactive DFGin 4.377 15.832 None -69.53, 164.86 -53.4, 113.84 -55.09, 81.41 35.63, 74.81 38.07, -90.08 out-out out 14.291 Saltbr-out 13.35 HRD-out -90.81, 75.3 -67.23, 24.34 out-out-out SNCooo out-out ActLoopNT-out 10.725 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -61.3, 146.02 APE9-dihe-na -103.14, 168.98 APE8-dihe-in -149.98, 115.15 APE8-rot-in 317.59 APE67-dihe-in -70.34, -0.48 -115.08, 9.43 APE12-dist-out 21.995 APE11-dist-out 19.636 APE10-dist-out 20.119 APE9-dist-out 12.619 None TPO170 TPO170 XRAY 3.02 0.217 0.288 C 346 287 13 0 0 0 [[12, 295]] 1.0 1ua2 CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 1UA2D P50613 13 311 346.0 ATP:384 ATPlike Inactive DFGin 3.971 15.482 None -66.13, 178.54 -66.01, 128.6 -62.88, 66.21 38.44, 67.87 63.18, -97.8 out-out out 13.242 Saltbr-out 13.575 HRD-out -80.45, 94.07 -71.75, -5.97 out-out-out SNCooo out-out ActLoopNT-out 10.896 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.63, 129.76 APE9-dihe-na -71.09, 152.84 APE8-dihe-in -147.91, 130.69 APE8-rot-out 68.98 APE67-dihe-in -88.14, 9.58 -128.15, 23.18 APE12-dist-out 22.145 APE11-dist-out 18.845 APE10-dist-out 20.01 APE9-dist-out 12.657 None TPO170 TPO170 XRAY 3.02 0.217 0.288 D 346 287 13 0 0 0 [[12, 295]] 1.0 1ua2 CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK9 CDK9_HUMAN 3BLQA P50750 7 325 372.0 ATP:332 ATPlike Active DFGin 6.983 15.235 BLAminus -137.33, 167.71 61.72, 82.78 -101.54, 27.58 292.13, 71.79 -68.35, -20.47 in-in in 9.514 Saltbr-in 3.257 HRD-in -70.77, -57.41 73.91, 6.35 in-in-in SNCiii in-in ActLoopNT-in 2.85 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.28, 155.2 APE9-dihe-na 75.14, 129.25 APE8-dihe-in -51.14, 147.2 APE8-rot-in 304.68 APE67-dihe-in -62.86, -25.73 -50.2, -49.1 APE12-dist-in 13.028 APE11-dist-in 11.03 APE10-dist-in 6.896 APE9-dist-in 3.154 None TPO186 TPO186 XRAY 2.9 0.174 0.234 A 331 296 23 0 0 7 [[19, 315]] 1.0 3blq CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CMGC CSNK2A1 CSK21_HUMAN 5CU6A P68400 3 329 391.0 ATP:401 ATPlike Active DFGin 7.373 16.301 BLAminus -117.96, -176.97 52.74, 80.35 -94.88, 19.06 296.35, 83.62 -69.11, -18.98 in-in in 9.296 Saltbr-in 2.997 HRD-in -73.54, -48.21 69.17, 10.55 in-in-in SNCiii in-in ActLoopNT-in 2.894 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.92, 173.11 APE9-dihe-na 58.61, 170.65 APE8-dihe-in -94.81, 150.1 APE8-rot-in 295.17 APE67-dihe-in -71.66, -13.32 -37.08, -56.84 APE12-dist-in 12.652 APE11-dist-in 10.334 APE10-dist-in 6.182 APE9-dist-in 3.146 R21S,K74A,K75A,K76A None None XRAY 1.36 0.188 0.209 A 328 327 0 0 0 0 [[39, 324]] 1.0 5cu6 CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZYDA P68400 3 329 391.0 ATP:403,KD6:404 ATPlike,Allosteric Active DFGin 7.329 16.214 BLAminus -118.97, -177.69 55.36, 75.35 -91.38, 15.36 296.7, 79.46 -65.95, -20.35 in-in in 9.271 Saltbr-in 2.864 HRD-in -76.19, -47.14 68.74, 13.25 in-in-in SNCiii in-in ActLoopNT-in 2.861 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.11, 172.03 APE9-dihe-na 59.78, 163.78 APE8-dihe-in -88.12, 149.21 APE8-rot-in 297.74 APE67-dihe-in -70.35, -14.8 -37.52, -55.55 APE12-dist-in 12.665 APE11-dist-in 10.191 APE10-dist-in 6.197 APE9-dist-in 3.192 R21S,K74A,K75A,K76A None None XRAY 1.404 0.199 0.214 A 328 327 0 0 0 0 [[39, 324]] 1.0 7zyd CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZYRA P68400 3 329 391.0 ATP:401,KF6:406 ATPlike,Allosteric Active DFGin 7.384 16.336 BLAminus -115.5, -176.17 54.52, 75.81 -90.94, 15.84 295.5, 83.13 -67.01, -21.05 in-in in 9.3 Saltbr-in 3.067 HRD-in -73.81, -46.94 67.44, 10.6 in-in-in SNCiii in-in ActLoopNT-in 2.962 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.26, 163.7 APE9-dihe-na 66.11, 155.14 APE8-dihe-in -79.05, 149.29 APE8-rot-in 297.87 APE67-dihe-in -66.86, -16.16 -37.19, -56.72 APE12-dist-in 12.649 APE11-dist-in 10.272 APE10-dist-in 6.096 APE9-dist-in 3.282 R21S,K74A,K75A,K76A None None XRAY 1.85 0.17 0.209 A 328 327 0 0 0 0 [[39, 324]] 1.0 7zyr CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 8AECA P68400 3 329 391.0 ATP:401,LW3:404 ATPlike,Allosteric Inactive DFGin 7.176 16.144 BLAminus -118.04, -179.83 50.85, 85.39 -95.14, 14.95 295.73, 81.33 -66.57, -20.11 in-in in 9.263 Saltbr-in 2.828 HRD-in -74.16, -49.17 69.92, 11.72 in-in-out SNCiio in-out ActLoopNT-in 2.841 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.03, 173.8 APE9-dihe-na 56.87, 164.78 APE8-dihe-in -92.58, 150.13 APE8-rot-out 58.14 APE67-dihe-in -68.24, -15.5 -36.53, -56.67 APE12-dist-in 12.634 APE11-dist-in 10.289 APE10-dist-in 6.179 APE9-dist-in 3.113 R21S,K74A,K75A,K76A None None XRAY 1.09 0.196 0.209 A 328 327 0 0 0 0 [[39, 324]] 1.0 8aec CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OSPA P68400 3 329 391.0 ATP:401,A9W:406 ATPlike,Allosteric Active DFGin 7.448 16.259 BLAminus -112.91, -173.94 47.41, 80.27 -93.43, 19.44 295.5, 80.71 -64.79, -26.04 in-in in 9.236 Saltbr-in 2.811 HRD-in -68.59, -50.2 68.38, 8.36 in-in-in SNCiii in-in ActLoopNT-in 2.961 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.65, 166.65 APE9-dihe-na 64.03, 159.2 APE8-dihe-in -80.26, 148.93 APE8-rot-in 296.57 APE67-dihe-in -70.89, -16.0 -37.06, -53.51 APE12-dist-in 12.712 APE11-dist-in 10.365 APE10-dist-in 6.135 APE9-dist-in 3.332 R21S,K74A,K75A,K76A None None XRAY 1.91 0.174 0.213 A 342 327 0 0 0 0 [[39, 324]] 1.0 5osp CMGC_CSNK2A1_HUMAN CMGC 9.4e-69 237.9 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OSRA P68400 3 329 391.0 ATP:403,AFK:404 ATPlike,Allosteric Active DFGin 7.39 16.235 BLAminus -115.2, -175.48 53.01, 75.53 -91.02, 17.2 296.18, 83.93 -66.77, -22.5 in-in in 9.17 Saltbr-in 2.886 HRD-in -76.06, -46.71 67.27, 11.5 in-in-in SNCiii in-in ActLoopNT-in 2.902 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.95, 170.87 APE9-dihe-na 60.56, 162.64 APE8-dihe-in -87.43, 145.48 APE8-rot-in 300.92 APE67-dihe-in -69.88, -13.97 -33.79, -56.46 APE12-dist-in 12.727 APE11-dist-in 10.365 APE10-dist-in 6.184 APE9-dist-in 3.167 R21S,K74A,K75A,K76A None None XRAY 1.57 0.177 0.209 A 342 327 0 0 0 0 [[39, 324]] 1.0 5osr CMGC_CSNK2A1_HUMAN CMGC 9.4e-69 237.9 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZY2A P68400 3 329 391.0 ATP:401,H4N:404,H4N:405 ATPlike,Allosteric,Allosteric Active DFGin 7.467 16.28 BLAminus -114.82, -177.5 55.14, 73.38 -87.5, 13.22 295.06, 80.66 -60.96, -25.13 in-in in 9.251 Saltbr-in 2.931 HRD-in -72.23, -48.39 67.99, 7.65 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.44, 169.73 APE9-dihe-na 59.19, 155.39 APE8-dihe-in -76.55, 147.29 APE8-rot-in 280.93 APE67-dihe-in -68.75, -13.44 -39.25, -54.49 APE12-dist-in 12.699 APE11-dist-in 10.36 APE10-dist-in 6.164 APE9-dist-in 3.268 R21S,K74A,K75A,K76A None None XRAY 1.51 0.189 0.21 A 328 327 0 0 0 0 [[39, 324]] 1.0 7zy2 CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZYOA P68400 3 329 391.0 ATP:401,KEX:404,KEX:405 ATPlike,Allosteric,Allosteric Active DFGin 7.502 16.398 BLAminus -113.84, -177.01 53.93, 77.01 -92.97, 16.97 297.5, 80.44 -65.6, -20.61 in-in in 9.197 Saltbr-in 2.93 HRD-in -77.03, -47.55 70.73, 4.92 in-in-in SNCiii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.4, 169.84 APE9-dihe-na 59.33, 166.07 APE8-dihe-in -87.44, 145.03 APE8-rot-in 291.2 APE67-dihe-in -67.16, -16.67 -36.15, -55.82 APE12-dist-in 12.756 APE11-dist-in 10.601 APE10-dist-in 6.194 APE9-dist-in 3.221 R21S,K74A,K75A,K76A None None XRAY 1.58 0.176 0.204 A 328 327 0 0 0 0 [[39, 324]] 1.0 7zyo CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OS7B P68400 3 327 391.0 A8Q:402,ATP:403 Allosteric,ATPlike Active DFGin 7.403 16.286 BLAminus -113.36, -175.81 49.81, 80.69 -97.06, 16.82 294.27, 80.08 -65.25, -22.08 in-in in 9.411 Saltbr-in 2.797 HRD-in -70.47, -48.19 65.29, 14.71 in-in-in SNCiii in-in ActLoopNT-in 2.857 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.46, 173.88 APE9-dihe-na 61.83, 168.57 APE8-dihe-in -97.24, 140.84 APE8-rot-in 297.98 APE67-dihe-in -62.16, -22.89 -29.44, -59.48 APE12-dist-in 12.639 APE11-dist-in 10.371 APE10-dist-in 6.029 APE9-dist-in 3.111 R21S None None XRAY 1.66 0.222 0.247 B 352 325 0 0 0 0 [[39, 324]] 1.0 5os7 CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6GMDA P68400 3 327 391.0 A8Q:402,ATP:403 Allosteric,ATPlike Active DFGin 7.403 16.286 BLAminus -113.36, -175.81 49.81, 80.69 -97.06, 16.82 294.27, 80.08 -65.25, -22.08 in-in in 9.411 Saltbr-in 2.797 HRD-in -70.47, -48.19 65.29, 14.71 in-in-in SNCiii in-in ActLoopNT-in 2.857 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.46, 173.88 APE9-dihe-na 61.83, 168.57 APE8-dihe-in -97.24, 140.84 APE8-rot-in 297.98 APE67-dihe-in -62.16, -21.58 -29.44, -59.48 APE12-dist-in 12.639 APE11-dist-in 10.371 APE10-dist-in 6.029 APE9-dist-in 3.111 R21S None None XRAY 1.66 0.222 0.247 A 352 325 0 0 0 0 [[39, 324]] 1.0 6gmd CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5CVFA P68400 3 329 391.0 54Z:401,ATP:402 Allosteric,ATPlike Active DFGin 7.47 16.268 BLAminus -117.2, -174.73 54.63, 71.77 -90.8, 22.72 298.48, 81.13 -69.82, -23.93 in-in in 9.281 Saltbr-in 2.82 HRD-in -73.12, -49.94 68.07, 7.39 in-in-in SNCiii in-in ActLoopNT-in 2.918 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.49, 166.86 APE9-dihe-na 61.99, 156.53 APE8-dihe-in -74.21, 147.85 APE8-rot-in 294.94 APE67-dihe-in -65.44, -19.86 -39.38, -55.54 APE12-dist-in 12.666 APE11-dist-in 10.304 APE10-dist-in 6.173 APE9-dist-in 3.251 R21S,K74A,K75A,K76A None None XRAY 1.63 0.201 0.209 A 328 325 2 0 0 0 [[39, 324]] 1.0 5cvf CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6FVFA P68400 3 329 391.0 503:401,ATP:402 Allosteric,ATPlike Inactive DFGin 7.458 15.996 BLAminus -117.08, -172.6 51.64, 74.63 -91.13, 21.7 296.66, 78.77 -67.99, -24.04 in-in in 9.37 Saltbr-in 2.804 HRD-in -73.47, -46.21 64.83, 11.56 in-in-out SNCiio in-out ActLoopNT-in 2.86 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.11, 170.35 APE9-dihe-na 60.67, 163.08 APE8-dihe-in -84.61, 146.09 APE8-rot-out 196.52 APE67-dihe-in -71.22, -11.21 -34.5, -54.96 APE12-dist-in 12.745 APE11-dist-in 10.441 APE10-dist-in 6.28 APE9-dist-in 3.131 R21S,K74A,K75A,K76A None None XRAY 1.47 0.201 0.222 A 328 327 0 0 0 0 [[39, 324]] 1.0 6fvf CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6FVGA P68400 3 329 391.0 E8K:401,ATP:402 Allosteric,ATPlike Inactive DFGin 7.564 16.249 BLAminus -114.12, -177.27 49.95, 79.39 -92.46, 19.09 295.44, 80.72 -62.08, -29.09 in-in in 9.471 Saltbr-in 2.867 HRD-in -71.26, -47.89 65.91, 11.22 in-in-out SNCiio in-out ActLoopNT-in 2.92 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -131.37, 168.11 APE9-dihe-na 62.71, 167.0 APE8-dihe-in -87.82, 142.1 APE8-rot-out 201.01 APE67-dihe-in -70.04, -16.46 -32.6, -53.52 APE12-dist-in 12.902 APE11-dist-in 10.544 APE10-dist-in 6.345 APE9-dist-in 3.208 R21S,K74A,K75A,K76A None None XRAY 1.6 0.208 0.229 A 328 327 0 0 0 0 [[39, 324]] 1.0 6fvg CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 8AEKA P68400 3 329 391.0 LVL:401,ATP:402 Allosteric,ATPlike Active DFGin 7.359 16.189 BLAminus -116.05, -177.84 59.67, 69.99 -88.27, 14.27 295.52, 85.07 -64.38, -21.31 in-in in 9.205 Saltbr-in 2.816 HRD-in -74.44, -47.13 67.98, 9.84 in-in-in SNCiii in-in ActLoopNT-in 2.928 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.41, 169.56 APE9-dihe-na 60.21, 157.69 APE8-dihe-in -79.56, 148.43 APE8-rot-in 292.83 APE67-dihe-in -70.07, -13.69 -40.23, -52.63 APE12-dist-in 12.638 APE11-dist-in 10.319 APE10-dist-in 6.099 APE9-dist-in 3.21 R21S,K74A,K75A,K76A None None XRAY 1.65 0.173 0.198 A 328 327 0 0 0 0 [[39, 324]] 1.0 8aek CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 8AEMA P68400 3 329 391.0 LVF:407,ATP:408 Allosteric,ATPlike Active DFGin 7.399 16.187 BLAminus -114.2, -178.47 56.21, 75.05 -90.39, 15.9 296.69, 81.8 -66.43, -20.83 in-in in 9.132 Saltbr-in 2.816 HRD-in -72.91, -51.16 68.69, 11.11 in-in-in SNCiii in-in ActLoopNT-in 2.905 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.83, 169.06 APE9-dihe-na 58.87, 157.76 APE8-dihe-in -77.1, 150.54 APE8-rot-in 294.73 APE67-dihe-in -68.78, -13.55 -40.19, -53.95 APE12-dist-in 12.744 APE11-dist-in 10.417 APE10-dist-in 6.256 APE9-dist-in 3.215 R21S,K74A,K75A,K76A None None XRAY 1.6 0.19 0.212 A 328 327 0 0 0 0 [[39, 324]] 1.0 8aem CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5CSHA P68400 4 327 391.0 54E:401,54E:402,ATP:403 Allosteric,Allosteric,ATPlike Active DFGin 7.436 16.475 BLAminus -114.33, -175.52 50.17, 77.83 -91.69, 16.93 295.31, 78.96 -64.52, -21.3 in-in in 9.606 Saltbr-in 2.798 HRD-in -72.7, -45.69 67.95, 9.72 in-in-in SNCiii in-in ActLoopNT-in 2.962 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.3, 172.6 APE9-dihe-na 60.22, 166.59 APE8-dihe-in -92.85, 140.16 APE8-rot-in 301.7 APE67-dihe-in -64.39, -20.56 -30.14, -59.7 APE12-dist-in 12.508 APE11-dist-in 10.286 APE10-dist-in 6.015 APE9-dist-in 3.087 R21S None None XRAY 1.59 0.194 0.207 A 352 324 0 0 0 0 [[39, 324]] 1.0 5csh CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5CSHB P68400 2 328 391.0 54E:403,54E:404,ATP:405 Allosteric,Allosteric,ATPlike Active DFGin 7.443 16.293 BLAminus -115.21, -175.71 50.61, 77.51 -92.19, 18.86 294.88, 77.24 -65.62, -21.94 in-in in 9.366 Saltbr-in 2.774 HRD-in -75.48, -46.24 69.71, 9.97 in-in-in SNCiii in-in ActLoopNT-in 2.989 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.44, 174.47 APE9-dihe-na 60.65, 166.44 APE8-dihe-in -96.7, 141.75 APE8-rot-in 305.79 APE67-dihe-in -65.63, -20.28 -30.96, -58.74 APE12-dist-in 12.584 APE11-dist-in 10.424 APE10-dist-in 6.071 APE9-dist-in 3.124 R21S None None XRAY 1.59 0.194 0.207 B 352 323 4 0 0 0 [[39, 324]] 1.0 5csh CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OS7A P68400 3 328 391.0 A8Q:404,A8Q:405,ATP:406 Allosteric,Allosteric,ATPlike Active DFGin 7.464 16.089 BLAminus -111.7, -175.06 51.27, 78.03 -95.04, 15.76 293.36, 80.0 -65.49, -19.43 in-in in 9.208 Saltbr-in 2.758 HRD-in -69.55, -50.38 66.74, 15.37 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.67, 175.58 APE9-dihe-na 57.11, 170.24 APE8-dihe-in -96.94, 142.73 APE8-rot-in 298.08 APE67-dihe-in -63.57, -23.25 -31.45, -59.13 APE12-dist-in 12.662 APE11-dist-in 10.379 APE10-dist-in 6.175 APE9-dist-in 3.132 R21S None None XRAY 1.66 0.222 0.247 A 352 326 0 0 0 0 [[39, 324]] 1.0 5os7 CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6GMDB P68400 3 328 391.0 A8Q:404,A8Q:405,ATP:406 Allosteric,Allosteric,ATPlike Active DFGin 7.464 16.089 BLAminus -111.7, -175.06 51.27, 78.03 -95.04, 15.76 293.36, 80.0 -65.49, -19.43 in-in in 9.208 Saltbr-in 2.758 HRD-in -69.55, -50.38 66.74, 15.37 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.67, 175.58 APE9-dihe-na 57.11, 170.24 APE8-dihe-in -96.94, 142.73 APE8-rot-in 298.08 APE67-dihe-in -63.57, -23.25 -31.45, -59.13 APE12-dist-in 12.662 APE11-dist-in 10.379 APE10-dist-in 6.175 APE9-dist-in 3.132 R21S None None XRAY 1.66 0.222 0.247 B 352 326 0 0 0 0 [[39, 324]] 1.0 6gmd CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OS8A P68400 3 329 391.0 J27:404,J27:405,J27:406,ATP:407 Allosteric,Allosteric,Allosteric,ATPlike Active DFGin 7.45 16.146 BLAminus -116.36, -176.24 53.52, 76.44 -92.27, 17.36 295.25, 83.47 -66.45, -20.94 in-in in 9.232 Saltbr-in 2.789 HRD-in -76.31, -47.96 70.56, 8.8 in-in-in SNCiii in-in ActLoopNT-in 2.902 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.3, 166.93 APE9-dihe-na 62.26, 151.31 APE8-dihe-in -76.68, 145.67 APE8-rot-in 296.22 APE67-dihe-in -69.08, -13.55 -36.03, -55.39 APE12-dist-in 12.667 APE11-dist-in 10.309 APE10-dist-in 6.187 APE9-dist-in 3.313 R21S,K74A,K75A,K76A None None XRAY 1.55 0.178 0.201 A 328 327 0 0 0 0 [[39, 324]] 1.0 5os8 CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OTRA P68400 3 329 391.0 AU8:403,AU8:404,AU8:405,ATP:406 Allosteric,Allosteric,Allosteric,ATPlike Active DFGin 7.468 16.282 BLAminus -118.34, -175.14 53.67, 73.1 -89.26, 15.26 295.08, 81.83 -61.86, -25.81 in-in in 9.365 Saltbr-in 2.951 HRD-in -75.87, -45.88 70.89, 5.51 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.59, 162.52 APE9-dihe-na 63.44, 152.89 APE8-dihe-in -75.69, 144.57 APE8-rot-in 311.11 APE67-dihe-in -70.25, -15.02 -34.48, -55.38 APE12-dist-in 12.809 APE11-dist-in 10.57 APE10-dist-in 6.339 APE9-dist-in 3.607 R21S,K74A,K75A,K76A None None XRAY 1.52 0.18 0.202 A 342 327 0 0 0 0 [[39, 324]] 1.0 5otr CMGC_CSNK2A1_HUMAN CMGC 9.4e-69 237.9 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
OTHER TTK TTK_HUMAN 3HMNA P33981 516 794 857.0 ATP:1 ATPlike Inactive DFGin 3.999 14.991 ABAminus -98.05, -9.81 -153.31, 160.67 -110.5, 6.35 307.22, 150.55 69.66, 19.48 out-out out 10.962 Saltbr-out 6.528 HRD-in -68.45, -50.57 72.29, 2.18 out-out-out SNCooo out-out ActLoopNT-out 11.646 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 102.39 APE9-dihe-na -78.34, -151.63 APE8-dihe-in -168.7, 144.18 APE8-rot-in 299.37 APE67-dihe-in -66.82, -19.22 -122.77, 14.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.622 APE9-dist-out 12.191 None None None XRAY 2.7 0.223 0.265 A 342 255 24 0 0 12 [[525, 791]] 1.0 3hmn OTHER_TTK_HUMAN CAMK 1.1e-53 188.1 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
RGC NPR1 ANPRA_HUMAN 9BCOA P16066 498 1053 1061.0 ATP:61101 ATPlike Pseudo DFGin 6.5 14.828 BLBplus -89.25, -164.06 42.72, 55.71 -135.24, 156.32 73.6, 95.91 78.22, -166.07 out-none out 16.928 Saltbr-none 999.0 HRD-out -74.2, 156.17 -59.96, -57.76 none-out-out SNCnoo out-out ActLoopNT-out 12.014 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -68.12, -1.53 APE9-dihe-na -60.93, -51.9 APE8-dihe-in -129.45, 85.23 APE8-rot-none 999.0 APE67-dihe-in -58.29, -38.75 -145.34, 13.28 APE12-dist-out 23.574 APE11-dist-out 20.43 APE10-dist-out 24.55 APE9-dist-out 15.858 None None None EM 4.4 999.0 999.0 A 1040 521 21 0 0 0 [[539, 803]] 1.0 9bco RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6 265 260 677 678 679 681 683 567 583 587 657 659 658 660 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCOB P16066 501 1053 1061.0 ATP:61101 ATPlike Pseudo DFGin 6.035 14.05 BLBplus -88.95, 166.99 56.44, 21.66 -61.11, 145.38 64.96, 87.18 86.53, -116.67 out-none out 15.454 Saltbr-none 999.0 HRD-in -114.17, -53.78 98.92, -43.57 none-out-out SNCnoo out-out ActLoopNT-out 9.447 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_oooo APE10-dihe-na -52.94, -51.71 APE9-dihe-na -111.55, -27.36 APE8-dihe-out -110.69, 11.24 APE8-rot-none 999.0 APE67-dihe-in -47.42, -35.74 -121.93, -1.95 APE12-dist-out 18.204 APE11-dist-out 21.211 APE10-dist-out 24.218 APE9-dist-out 14.706 None None None EM 4.4 999.0 999.0 B 1040 517 22 0 0 0 [[539, 803]] 1.0 9bco RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6 265 260 677 678 679 681 683 567 583 587 657 659 658 660 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCPA P16066 505 842 1061.0 ATP:61101 ATPlike Pseudo DFGin 5.276 13.499 BLBplus -119.01, 147.56 55.81, 47.24 -98.35, -175.13 72.56, 101.5 63.71, -113.08 out-none out 15.017 Saltbr-none 999.0 HRD-in -101.28, -53.45 85.86, -1.89 none-out-out SNCnoo out-out ActLoopNT-out 10.061 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -56.32, -46.22 APE9-dihe-na -56.3, -35.86 APE8-dihe-out -106.06, -11.55 APE8-rot-na 74.77 APE67-dihe-in -55.12, -26.01 -77.38, -2.19 APE12-dist-out 20.65 APE11-dist-out 18.471 APE10-dist-out 23.005 APE9-dist-out 14.329 None None None EM 4.1 999.0 999.0 A 1040 314 21 0 0 0 [[539, 803]] 1.0 9bcp RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6 265 260 677 678 679 681 683 567 583 587 657 659 658 660 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCPB P16066 503 841 1061.0 ATP:61101 ATPlike Pseudo DFGin 5.356 16.761 BLBtrans -138.66, -167.01 55.46, 41.07 -76.35, 89.03 193.7, 109.94 60.64, -128.0 out-none out 16.649 Saltbr-none 999.0 HRD-out -58.73, 127.47 -87.85, -41.33 none-out-out SNCnoo out-out ActLoopNT-out 12.183 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na -63.64, -13.04 APE9-dihe-na -73.26, -45.78 APE8-dihe-out -94.47, 23.47 APE8-rot-na 181.32 APE67-dihe-out -126.85, -50.61 -149.46, 92.68 APE12-dist-out 22.361 APE11-dist-out 19.678 APE10-dist-out 23.708 APE9-dist-out 15.401 None None None EM 4.1 999.0 999.0 B 1040 304 21 0 0 0 [[539, 803]] 1.0 9bcp RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6 265 260 677 678 679 681 683 567 583 587 657 659 658 660 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCSA P16066 503 1055 1061.0 ATP:61100 ATPlike Pseudo DFGin 7.694 15.737 None -74.51, -65.19 38.98, 36.73 -149.34, 137.28 313.08, 80.76 -109.19, -24.55 out-none out 17.336 Saltbr-none 999.0 HRD-in -67.46, -13.34 80.4, -46.04 none-out-out SNCnoo out-out ActLoopNT-out 11.453 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -59.39, -44.12 APE9-dihe-na -70.77, -47.95 APE8-dihe-out -62.03, -25.18 APE8-rot-na 74.24 APE67-dihe-in -57.49, -15.22 -74.7, -41.95 APE12-dist-out 24.021 APE11-dist-out 19.76 APE10-dist-out 23.161 APE9-dist-out 13.347 None None None EM 4.4 999.0 999.0 A 1040 515 23 0 0 0 [[539, 803]] 1.0 9bcs RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6 265 260 677 678 679 681 683 567 583 587 657 659 658 660 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCSB P16066 505 1055 1061.0 ATP:61100 ATPlike Pseudo None 999.0 999.0 None -84.33, 145.87 61.52, 18.75 -86.58, 62.78 999.0, 999.0 166.38, -163.08 out-none out 16.274 Saltbr-none 999.0 HRD-in -63.93, -40.93 80.49, -6.63 none-out-out SNCnoo out-out ActLoopNT-out 11.232 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_oooo APE10-dihe-na -65.87, -23.07 APE9-dihe-na -84.75, -47.21 APE8-dihe-out -94.13, -13.59 APE8-rot-none 999.0 APE67-dihe-in -66.6, -21.85 -106.41, 28.83 APE12-dist-out 21.881 APE11-dist-out 20.406 APE10-dist-out 24.72 APE9-dist-out 14.261 None None None EM 4.4 999.0 999.0 B 1040 523 25 0 0 0 [[539, 803]] 1.0 9bcs RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6 265 260 677 678 679 681 683 567 583 587 657 659 658 660 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
STE MAP2K1 MP2K1_HUMAN 4AN3A Q02750 61 381 393.0 ATP:61383,5Y0:61384 ATPlike,Type3 Inactive DFGin 6.372 14.221 BLBplus -129.12, 178.33 68.61, 30.98 -85.55, 168.03 44.05, 86.92 -96.2, 75.38 out-out out 15.694 Saltbr-out 15.416 HRD-in -67.68, -62.51 95.67, -17.38 out-out-out SNCooo out-out ActLoopNT-out 9.23 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_onno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -140.36 APE8-dihe-in -98.61, 79.73 APE8-rot-in 326.73 APE67-dihe-in -67.76, -12.96 -73.18, -22.73 APE12-dist-out 17.69 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.352 S218E,S222E,G328A None None XRAY 2.1 0.229 0.283 A 301 277 2 0 0 2 [[68, 361]] 1.0 4an3 STE_MAP2K1_HUMAN STE 1.7e-99 338.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3OS3A Q02750 62 378 393.0 ATP:1,3OS:400 ATPlike,Type3 Inactive DFGin 6.24 13.534 BLBplus -145.24, 170.05 62.26, 36.89 -93.68, 158.58 44.13, 99.29 -73.81, 106.93 out-out out 15.504 Saltbr-out 15.394 HRD-in -59.5, -62.21 84.93, 3.41 out-out-out SNCooo out-out ActLoopNT-out 9.408 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -133.7, -173.12 APE9-dihe-na 93.3, -146.81 APE8-dihe-out -139.28, -26.49 APE8-rot-out 64.05 APE67-dihe-out 179.14, 100.5 -105.07, -165.97 APE12-dist-out 14.865 APE11-dist-out 20.099 APE10-dist-out 20.846 APE9-dist-out 14.0 None None None XRAY 2.8 0.268 0.356 A 307 272 13 0 0 0 [[68, 361]] 1.0 3os3 STE_MAP2K1_HUMAN STE 9.7e-99 335.8 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3DV3A Q02750 62 382 393.0 ATP:69000,MEK:69001 ATPlike,Type3 Inactive DFGin 6.248 13.603 BLBplus -133.16, -177.92 60.69, 33.15 -89.5, 161.32 45.46, 91.05 -72.95, 66.6 out-out out 15.44 Saltbr-out 15.92 HRD-in -71.02, -56.25 85.34, -10.2 out-out-out SNCooo out-out ActLoopNT-out 9.434 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 147.19 APE8-dihe-out -113.44, 8.55 APE8-rot-out 63.26 APE67-dihe-out -136.65, 142.85 -161.65, 147.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.723 None None None XRAY 2.3 0.184 0.221 A 322 287 34 0 0 3 [[68, 361]] 1.0 3dv3 STE_MAP2K1_HUMAN STE 1.2e-97 332.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3PP1A Q02750 62 382 393.0 ATP:60400,IZG:60500 ATPlike,Type3 Inactive DFGin 6.243 13.533 BLBplus -142.73, -172.37 57.21, 29.66 -83.48, 161.89 45.19, 86.92 -94.1, 95.51 out-out out 15.575 Saltbr-out 15.664 HRD-in -75.88, -59.97 91.29, -12.92 out-out-out SNCooo out-out ActLoopNT-out 9.837 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -95.93, 115.09 APE9-dihe-na -80.03, 20.28 APE8-dihe-out -149.74, -167.9 APE8-rot-out 183.56 APE67-dihe-out -104.62, 136.28 16.12, 99.01 APE12-dist-out 17.803 APE11-dist-out 17.657 APE10-dist-out 19.872 APE9-dist-out 14.622 None None None XRAY 2.7 0.184 0.219 A 328 290 31 0 0 0 [[68, 361]] 1.0 3pp1 STE_MAP2K1_HUMAN STE 1.3e-97 332.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3EQBA Q02750 62 382 393.0 ATP:69001,LUG:60001 ATPlike,Type3 Inactive DFGin 6.367 13.816 BLBplus -126.21, -166.87 50.54, 41.27 -103.19, 173.93 44.2, 81.11 -86.45, 70.56 out-out out 15.551 Saltbr-out 16.099 HRD-in -69.12, -59.32 92.15, -13.52 out-out-out SNCooo out-out ActLoopNT-out 9.412 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -145.13 APE9-dihe-na 160.93, -130.46 APE8-dihe-out -134.08, -9.84 APE8-rot-out 185.08 APE67-dihe-out -100.78, 136.47 -136.54, 109.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.269 APE9-dist-out 13.074 None None None XRAY 2.62 0.212 0.264 A 333 288 33 0 0 3 [[68, 361]] 1.0 3eqb STE_MAP2K1_HUMAN STE 1.4e-97 332.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 1S9JA Q02750 62 382 393.0 ATP:60535,BBM:61001 ATPlike,Type3 Inactive DFGin 6.038 13.677 BLBplus -128.29, 177.35 60.26, 51.07 -106.68, 166.27 42.89, 83.29 -88.36, 87.09 out-out out 15.648 Saltbr-out 16.005 HRD-in -74.19, -52.1 76.2, -2.79 out-out-out SNCooo out-out ActLoopNT-out 9.347 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -65.48 APE9-dihe-na 93.04, 154.36 APE8-dihe-out -82.85, 11.58 APE8-rot-out 188.1 APE67-dihe-out -101.56, 129.66 -130.71, 111.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.148 APE9-dist-out 12.559 None None None XRAY 2.4 0.246 0.269 A 341 288 33 0 0 3 [[68, 361]] 1.0 1s9j STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3DY7A Q02750 62 364 393.0 ATP:9000,1CX:9002 ATPlike,Type3 Inactive DFGin 6.172 13.758 BLBplus -135.89, -175.79 54.31, 45.87 -100.93, 164.77 46.33, 84.08 -87.96, 76.55 out-out out 15.244 Saltbr-out 15.579 HRD-in -80.68, -50.01 86.81, -10.3 out-out-out SNCooo out-out ActLoopNT-out 9.463 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -93.77 APE8-dihe-out -68.47, -78.94 APE8-rot-in 288.45 APE67-dihe-out -129.83, 139.32 -78.41, 146.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.064 None None None XRAY 2.7 0.248 0.269 A 341 260 43 0 0 3 [[68, 361]] 1.0 3dy7 STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3E8NA Q02750 62 382 393.0 ATP:60600,VRA:61001 ATPlike,Type3 Inactive DFGin 6.195 13.819 BLBplus -141.11, 177.37 57.45, 45.25 -100.77, 153.06 46.07, 82.11 -71.63, 93.26 out-out out 15.413 Saltbr-out 15.348 HRD-in -66.77, -56.92 83.67, -13.1 out-out-out SNCooo out-out ActLoopNT-out 9.432 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_onoo APE10-dihe-na 999.0, -90.03 APE9-dihe-na 88.43, 141.27 APE8-dihe-out -49.1, -69.8 APE8-rot-out 147.13 APE67-dihe-out -116.51, 140.9 -59.5, 122.62 APE12-dist-out 18.883 APE11-dist-none 999.0 APE10-dist-out 19.986 APE9-dist-out 12.831 None None None XRAY 2.5 0.219 0.252 A 341 290 31 0 0 1 [[68, 361]] 1.0 3e8n STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3VVHA Q02750 62 382 393.0 ATP:60702,4BM:60703 ATPlike,Type3 Inactive DFGin 6.389 13.656 BLBplus -137.53, 173.5 63.48, 33.18 -82.96, 158.78 37.49, 96.63 -83.81, 69.64 out-out out 15.318 Saltbr-out 14.947 HRD-in -72.04, -55.34 81.65, -10.46 out-out-out SNCooo out-out ActLoopNT-out 9.261 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -67.32 APE8-rot-in 311.04 APE67-dihe-out -121.47, 130.33 -95.91, 138.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.199 0.225 A 341 286 35 0 0 5 [[68, 361]] 1.0 3vvh STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3VVHB Q02750 62 382 393.0 ATP:60502,4BM:60503 ATPlike,Type3 Inactive DFGin 6.139 13.837 BLBplus -134.79, 175.55 59.54, 35.53 -87.99, 165.28 42.27, 92.99 -92.68, 76.34 out-out out 15.261 Saltbr-out 14.977 HRD-in -72.52, -58.36 78.03, -3.83 out-out-out SNCooo out-out ActLoopNT-out 9.105 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -110.08, 147.03 APE9-dihe-na 98.19, 168.29 APE8-dihe-out -85.55, -32.58 APE8-rot-in 303.1 APE67-dihe-out -124.7, 138.59 -110.8, 145.07 APE12-dist-out 16.971 APE11-dist-out 20.559 APE10-dist-out 18.851 APE9-dist-out 12.926 None None None XRAY 2.0 0.199 0.225 B 341 289 32 0 0 0 [[68, 361]] 1.0 3vvh STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3VVHC Q02750 62 381 393.0 ATP:60502,4BM:60503 ATPlike,Type3 Inactive DFGin 6.119 13.884 BLBplus -136.04, 173.19 62.4, 33.8 -87.32, 164.72 43.72, 90.03 -81.06, 61.43 out-out out 15.395 Saltbr-out 14.906 HRD-in -71.92, -60.52 80.82, -10.24 out-out-out SNCooo out-out ActLoopNT-out 9.005 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -107.33, 145.59 APE9-dihe-na 98.43, 176.47 APE8-dihe-out -99.48, -17.12 APE8-rot-out 62.73 APE67-dihe-out -124.21, 136.5 -120.29, 144.56 APE12-dist-out 16.918 APE11-dist-out 20.623 APE10-dist-out 18.804 APE9-dist-out 12.965 None None None XRAY 2.0 0.199 0.225 C 341 282 38 0 0 0 [[68, 361]] 1.0 3vvh STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 2P55A Q02750 62 382 393.0 MRA:69000,ATP:69001 Type3,ATPlike Inactive DFGin 6.163 13.382 BLBplus -134.23, -173.95 50.87, 43.67 -95.4, 166.24 42.0, 89.87 -87.86, 76.42 out-out out 15.218 Saltbr-out 15.346 HRD-in -70.81, -55.41 89.6, -22.02 out-out-out SNCooo out-out ActLoopNT-out 9.468 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -78.03 APE9-dihe-na 94.66, -135.55 APE8-dihe-out -131.47, -8.61 APE8-rot-out 200.5 APE67-dihe-out -121.47, 132.61 -102.76, 124.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.174 APE9-dist-out 13.979 None None None XRAY 2.8 0.228 0.301 A 333 288 33 0 0 3 [[68, 361]] 1.0 2p55 STE_MAP2K1_HUMAN STE 1.4e-97 332.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3V01A Q02750 62 382 393.0 3V0:60501,ATP:60502 Type3,ATPlike Inactive DFGin 6.105 13.424 BLBplus -142.06, -173.42 54.59, 34.91 -91.82, 163.8 47.01, 90.27 -88.09, 75.03 out-out out 15.564 Saltbr-out 15.778 HRD-in -62.64, -63.68 88.6, -7.02 out-out-out SNCooo out-out ActLoopNT-out 9.277 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -67.65 APE9-dihe-na 102.3, -166.23 APE8-dihe-out -116.29, 3.8 APE8-rot-out 189.24 APE67-dihe-out -108.4, 130.42 -142.07, 120.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.077 APE9-dist-out 12.838 None None None XRAY 2.705 0.189 0.24 A 341 288 33 0 0 3 [[68, 361]] 1.0 3v01 STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3V04A Q02750 62 382 393.0 V04:60501,ATP:60502 Type3,ATPlike Inactive DFGin 6.202 13.466 BLBplus -139.99, -177.53 54.26, 36.29 -92.6, 163.3 43.17, 90.4 -92.7, 75.2 out-out out 15.613 Saltbr-out 16.049 HRD-in -56.82, -58.2 81.63, -6.31 out-out-out SNCooo out-out ActLoopNT-out 9.11 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -43.92 APE9-dihe-na 143.86, 160.52 APE8-dihe-out -85.24, -10.44 APE8-rot-out 182.43 APE67-dihe-out -103.47, 130.39 -134.15, 117.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.808 APE9-dist-out 12.649 None None None XRAY 2.7 0.213 0.243 A 341 288 33 0 0 3 [[68, 361]] 1.0 3v04 STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K2 MP2K2_HUMAN 1S9IA P36507 60 393 400.0 ATP:535,5EA:1001 ATPlike,Type3 Inactive DFGin 6.287 13.269 BLBplus -139.34, -174.92 56.51, 21.27 -79.15, 150.55 47.45, 91.25 -79.77, 85.37 out-out out 15.529 Saltbr-out 17.297 HRD-out -62.14, 153.21 -129.12, 19.13 out-out-out SNCooo out-out ActLoopNT-out 8.898 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnoo APE10-dihe-na 999.0, 134.1 APE9-dihe-na -103.89, 62.93 APE8-dihe-out -65.91, -35.32 APE8-rot-in 354.81 APE67-dihe-out -93.63, 150.37 -174.34, 119.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 21.618 APE9-dist-out 12.732 None None None XRAY 3.2 0.294 0.364 A 354 303 31 0 0 4 [[72, 369]] 1.0 1s9i STE_MAP2K2_HUMAN STE 1.5e-97 331.9 1 257 257 211 212 213 215 217 101 118 122 191 193 192 194 249 237 232 231 230 229 228 227 226 148 Dual specificity mitogen-activated protein kinase kinase 2
STE MAP2K2 MP2K2_HUMAN 1S9IB P36507 59 389 400.0 ATP:537,5EA:1002 ATPlike,Type3 Inactive DFGin 6.282 13.638 BLBplus -139.5, 161.8 56.55, 60.44 -106.38, 150.17 37.7, 87.0 -78.89, 77.21 out-out out 15.534 Saltbr-out 15.004 HRD-out -92.42, 79.21 -68.62, 14.72 out-out-out SNCooo out-out ActLoopNT-out 9.517 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -33.93 APE8-rot-out 15.08 APE67-dihe-out -144.19, 132.88 -117.04, 157.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.294 0.364 B 354 291 40 0 0 6 [[72, 369]] 1.0 1s9i STE_MAP2K2_HUMAN STE 1.5e-97 331.9 1 257 257 211 212 213 215 217 101 118 122 191 193 192 194 249 237 232 231 230 229 228 227 226 148 Dual specificity mitogen-activated protein kinase kinase 2
STE PAK1 PAK1_HUMAN 3Q53A Q13153 250 541 545.0 ATP:1 ATPlike Inactive DFGin 6.546 15.968 BLAminus -131.41, -173.51 59.18, 73.62 -91.64, 12.88 288.75, 75.16 -60.67, -19.44 out-none out 10.159 Saltbr-none 999.0 HRD-in -69.79, -48.58 76.19, -3.19 none-in-in SNCnii in-in ActLoopNT-in 2.837 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.58, -17.38 APE9-dihe-na -66.64, 179.65 APE8-dihe-in -103.57, 123.03 APE8-rot-in 305.32 APE67-dihe-in -60.91, -26.26 -42.88, -52.15 APE12-dist-in 8.284 APE11-dist-in 10.463 APE10-dist-in 4.727 APE9-dist-in 3.438 K299R,L516I TPO423 TPO423 XRAY 2.09 0.207 0.223 A 306 292 0 0 0 0 [[270, 521]] 1.0 3q53 STE_PAK1_HUMAN STE 2.5e-94 321.4 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK4 PAK4_HUMAN 4XBRA O96013 177 589 591.0 ATP:60601 ATPlike Inactive DFGin 5.852 14.061 ABAminus -142.04, -22.23 -111.42, 72.59 -86.56, 10.51 310.81, 99.4 -46.84, -40.66 in-in in 7.009 Saltbr-in 3.158 HRD-in -84.11, -33.57 58.48, -1.88 in-in-in SNCiii in-in ActLoopNT-in 2.974 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.96, 132.02 APE9-dihe-na 150.85, -176.82 APE8-dihe-in -102.34, 122.5 APE8-rot-in 312.14 APE67-dihe-in -59.91, -25.15 -35.82, -60.88 APE12-dist-in 9.335 APE11-dist-in 11.927 APE10-dist-in 6.05 APE9-dist-in 3.396 None SEP474 SEP474 XRAY 2.94 0.191 0.23 A 366 293 0 0 0 0 [[321, 572]] 1.0 4xbr STE_PAK4_HUMAN STE 3.7e-88 301.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE STK24 STK24_HUMAN 3A7HA Q9Y6E0 18 310 443.0 ATP:60400 ATPlike Inactive DFGin 6.274 16.06 BLAminus -135.27, 174.99 54.48, 64.86 -70.71, -58.08 287.78, 76.92 45.88, -44.99 in-out in 9.722 Saltbr-out 4.493 HRD-in -66.74, -51.36 77.62, -11.47 out-in-in SNCoii in-in ActLoopNT-in 2.797 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.61, 151.93 APE9-dihe-na 118.1, -167.87 APE8-dihe-in -108.64, 120.02 APE8-rot-in 324.07 APE67-dihe-in -58.13, -27.9 -30.96, -56.98 APE12-dist-in 8.269 APE11-dist-in 11.137 APE10-dist-in 5.543 APE9-dist-in 3.566 None TPO190 TPO190 XRAY 1.96 0.21 0.252 A 303 290 0 0 0 0 [[36, 286]] 1.0 3a7h STE_STK24_HUMAN STE 3.6e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 3A7HB Q9Y6E0 17 310 443.0 ATP:60400 ATPlike Inactive DFGin 6.685 16.86 BLAminus -138.1, 177.76 56.48, 71.8 -87.83, 21.17 281.85, 78.43 -54.77, -28.24 out-out out 10.376 Saltbr-out 4.639 HRD-in -73.68, -49.41 75.79, -7.51 out-in-in SNCoii in-in ActLoopNT-in 2.816 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.6, 158.04 APE9-dihe-na 117.1, -164.51 APE8-dihe-in -112.27, 119.11 APE8-rot-in 308.97 APE67-dihe-in -56.45, -30.21 -34.32, -55.35 APE12-dist-in 8.215 APE11-dist-in 11.012 APE10-dist-in 5.261 APE9-dist-in 3.401 None TPO190 TPO190 XRAY 1.96 0.21 0.252 B 303 291 0 0 0 0 [[36, 286]] 1.0 3a7h STE_STK24_HUMAN STE 3.6e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STRADA STRAA_HUMAN 3GNIB Q7RTN6 60 431 431.0 ATP:60001 ATPlike Pseudo DFGin 5.228 13.358 BLAminus -109.39, -155.43 74.77, 29.57 -67.06, -15.75 299.34, 10.06 -54.98, -34.79 in-none in 9.9 Saltbr-none 999.0 HRD-in -71.88, -63.47 83.33, 4.11 none-in-out SNCnio in-out ActLoopNT-in 2.866 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_iooo APE10-dihe-na -73.5, 108.36 APE9-dihe-na 128.9, -33.16 APE8-dihe-out -82.37, -8.26 APE8-rot-na 193.56 APE67-dihe-in -56.7, -25.37 -48.29, -50.45 APE12-dist-in 8.527 APE11-dist-out 7.098 APE10-dist-out 12.899 APE9-dist-out 9.897 None None None XRAY 2.35 0.207 0.254 B 389 290 56 0 0 0 [[69, 379]] 1.0 3gni STE_STRADA_HUMAN STE 4.7e-87 297.8 1 257 257 212 213 214 216 218 100 118 122 192 194 193 195 261 247 242 241 240 239 238 237 236 148 STE20-related kinase adapter protein alpha
TKL ILK ILK_HUMAN 9D5IA Q13418 182 452 452.0 ATP:502 ATPlike Pseudo DFGinter 8.261 6.842 None -85.91, 104.5 -70.94, -26.25 -67.8, 1.23 999.0, 999.0 -109.51, 3.6 out-out out 13.611 Saltbr-out 13.777 HRD-out 63.45, 28.98 -91.0, 110.88 out-out-out SNCooo out-out ActLoopNT-out 6.365 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioo APE10-dihe-na -132.95, 115.89 APE9-dihe-na -99.41, -2.16 APE8-dihe-in -138.47, 54.8 APE8-rot-none 999.0 APE67-dihe-in -62.49, -23.03 -64.85, -19.12 APE12-dist-out 14.705 APE11-dist-in 13.99 APE10-dist-out 13.138 APE9-dist-out 13.265 R225A,C346S,C422S None None XRAY 1.5 0.23 0.267 A 271 271 0 0 0 0 [[192, 448]] 1.0 9d5i TKL_ILK_HUMAN TKL 2.8e-62 216.7 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 3KMWA Q13418 185 452 452.0 ATP:502 ATPlike Pseudo DFGinter 8.3 6.975 None -80.97, 99.65 -67.11, -24.75 -72.37, 0.55 999.0, 999.0 -103.25, 4.58 out-out out 13.496 Saltbr-out 14.041 HRD-out 59.64, 26.4 -91.04, 116.86 out-out-out SNCooo out-out ActLoopNT-out 6.367 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -122.08, 118.72 APE9-dihe-na -100.74, -5.98 APE8-dihe-in -137.53, 58.2 APE8-rot-none 999.0 APE67-dihe-in -63.57, -23.06 -67.47, -16.05 APE12-dist-out 14.71 APE11-dist-out 14.04 APE10-dist-out 13.057 APE9-dist-out 13.027 C346S,C422S None None XRAY 2.0 0.199 0.203 A 271 268 0 0 0 0 [[192, 448]] 1.0 3kmw TKL_ILK_HUMAN TKL 1.5e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 3REPA Q13418 185 452 452.0 ATP:502 ATPlike Pseudo DFGinter 8.264 6.894 None -81.35, 101.61 -70.12, -25.38 -69.18, -5.31 999.0, 999.0 -98.03, -0.84 out-out out 13.359 Saltbr-out 14.12 HRD-out 62.24, 23.62 -86.21, 112.03 out-out-out SNCooo out-out ActLoopNT-out 6.454 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioo APE10-dihe-na -114.84, 122.73 APE9-dihe-na -97.69, -5.36 APE8-dihe-in -136.02, 58.25 APE8-rot-none 999.0 APE67-dihe-in -57.73, -27.19 -63.83, -23.69 APE12-dist-out 14.498 APE11-dist-in 13.981 APE10-dist-out 12.94 APE9-dist-out 13.101 C346S,C422S None None XRAY 1.8 0.206 0.238 A 271 268 0 0 0 0 [[192, 448]] 1.0 3rep TKL_ILK_HUMAN TKL 1.5e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL KSR2 KSR2_HUMAN 2Y4IB Q6VAB6 653 931 950.0 ATP:1932 ATPlike Pseudo DFGin 6.039 13.357 BLBplus -163.04, 167.92 56.95, 32.67 -75.07, 155.41 46.1, 92.34 53.05, 51.5 out-none out 15.58 Saltbr-none 999.0 HRD-in -80.25, -38.53 67.56, -67.09 none-out-out SNCnoo out-out ActLoopNT-out 10.43 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -56.45, -137.53 APE9-dihe-na -67.8, 7.84 APE8-dihe-out -54.46, -37.41 APE8-rot-na 170.99 APE67-dihe-in -92.05, 13.42 -60.84, -28.22 APE12-dist-out 17.417 APE11-dist-out 14.576 APE10-dist-out 17.158 APE9-dist-out 12.262 None None None XRAY 3.46 0.233 0.293 B 319 265 14 0 0 10 [[665, 930]] 1.0 2y4i TKL_KSR2_HUMAN TKL 1.1e-70 244.1 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL LRRK2 LRRK2_HUMAN 8FO9A Q5S007 1329 2527 2527.0 ATP:2602 ATPlike Active DFGin 6.273 13.41 BLAminus -138.23, -175.7 59.6, 64.71 -84.85, 53.99 305.84, 101.34 -78.49, -28.55 in-in in 7.88 Saltbr-in 2.735 HRD-in -107.83, -47.31 66.25, 1.81 in-in-in SNCiii in-in ActLoopNT-in 3.031 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.21, 156.34 APE9-dihe-na 139.24, 152.96 APE8-dihe-in -67.96, 127.7 APE8-rot-in 305.42 APE67-dihe-inflip 98.56, -16.69 -58.5, 136.92 APE12-dist-in 9.183 APE11-dist-in 11.487 APE10-dist-in 6.004 APE9-dist-in 3.816 None None None EM 3.48 999.0 999.0 A 2527 1173 0 0 0 0 [[1875, 2134]] 1.0 8fo9 TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO9C Q5S007 1329 2527 2527.0 ATP:2602 ATPlike Active DFGin 6.275 13.405 BLAminus -138.14, -175.77 59.5, 64.85 -84.95, 53.97 305.9, 101.31 -78.52, -28.52 in-in in 7.883 Saltbr-in 2.729 HRD-in -108.59, -47.2 66.33, 1.76 in-in-in SNCiii in-in ActLoopNT-in 3.008 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.94, 156.21 APE9-dihe-na 139.37, 152.96 APE8-dihe-in -67.92, 127.71 APE8-rot-in 305.58 APE67-dihe-inflip 98.46, -16.81 -58.61, 136.94 APE12-dist-in 9.177 APE11-dist-in 11.503 APE10-dist-in 6.012 APE9-dist-in 3.804 None None None EM 3.48 999.0 999.0 C 2527 1173 0 0 0 0 [[1875, 2134]] 1.0 8fo9 TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LHTA Q5S007 558 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 9.844 8.295 None -64.84, 122.35 -98.75, -0.04 -71.37, -28.28 172.84, 65.91 -59.04, -42.88 out-out out 11.156 Saltbr-out 7.841 HRD-in -69.75, -40.92 72.72, -9.61 out-out-out SNCooo out-out ActLoopNT-out 9.784 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -82.21, -17.19 APE9-dihe-na 90.26, 154.46 APE8-dihe-in -57.7, 141.99 APE8-rot-in 318.57 APE67-dihe-in -63.97, -43.36 -55.36, -52.39 APE12-dist-in 9.673 APE11-dist-in 10.145 APE10-dist-out 14.096 APE9-dist-in 4.097 None None None EM 3.5 999.0 999.0 A 2527 1795 3 0 0 3 [[1875, 2134]] 1.0 7lht TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LHTB Q5S007 558 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 9.844 8.295 None -64.86, 122.35 -98.72, -0.04 -71.37, -28.3 172.84, 65.9 -59.09, -42.88 out-out out 11.156 Saltbr-out 7.841 HRD-in -69.81, -40.92 72.73, -9.55 out-out-out SNCooo out-out ActLoopNT-out 9.783 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -82.22, -17.15 APE9-dihe-na 90.23, 154.47 APE8-dihe-in -57.69, 142.03 APE8-rot-in 318.55 APE67-dihe-in -64.0, -43.36 -55.37, -52.4 APE12-dist-in 9.672 APE11-dist-in 10.145 APE10-dist-out 14.096 APE9-dist-in 4.097 None None None EM 3.5 999.0 999.0 B 2527 1795 3 0 0 3 [[1875, 2134]] 1.0 7lht TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LHWA Q5S007 540 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 10.349 8.277 None -70.88, 117.76 -93.02, 2.5 -63.92, -24.19 170.47, 59.39 -60.34, -43.84 out-out out 10.98 Saltbr-out 7.258 HRD-in -74.65, -33.87 72.74, -12.12 out-out-out SNCooo out-out ActLoopNT-out 9.631 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -74.42, -8.25 APE9-dihe-na 81.17, 153.49 APE8-dihe-in -58.6, 142.93 APE8-rot-in 304.43 APE67-dihe-in -63.74, -43.48 -51.59, -53.96 APE12-dist-in 10.236 APE11-dist-in 9.457 APE10-dist-out 13.872 APE9-dist-in 4.335 None None None EM 3.7 999.0 999.0 A 2527 1813 3 0 0 3 [[1875, 2134]] 1.0 7lhw TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LI4A Q5S007 558 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 9.844 8.294 None -64.77, 122.33 -98.76, -0.03 -71.41, -28.21 172.83, 65.95 -59.02, -42.88 out-out out 11.157 Saltbr-out 7.842 HRD-in -69.78, -40.92 72.72, -9.67 out-out-out SNCooo out-out ActLoopNT-out 9.784 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -82.19, -17.19 APE9-dihe-na 90.26, 154.48 APE8-dihe-in -57.73, 142.01 APE8-rot-in 318.58 APE67-dihe-in -63.98, -43.36 -55.36, -52.38 APE12-dist-in 9.673 APE11-dist-in 10.145 APE10-dist-out 14.096 APE9-dist-in 4.096 None None None EM 3.1 999.0 999.0 A 2527 1795 3 0 0 3 [[1875, 2134]] 1.0 7li4 TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO2E Q5S007 12 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 10.549 8.183 None -77.97, 115.31 -99.8, 16.1 -71.24, -24.34 179.0, 61.54 -64.41, -41.78 out-out out 11.347 Saltbr-out 7.851 HRD-in -73.2, -35.27 72.81, -10.29 out-out-out SNCooo out-out ActLoopNT-out 9.492 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -67.29, -18.03 APE9-dihe-na 75.0, 160.57 APE8-dihe-in -64.56, 133.01 APE8-rot-in 300.63 APE67-dihe-in -63.84, -35.14 -59.88, -35.03 APE12-dist-in 9.119 APE11-dist-in 10.588 APE10-dist-out 14.447 APE9-dist-in 4.382 None None None EM 4.13 999.0 999.0 E 2527 2275 4 0 0 3 [[1875, 2134]] 1.0 8fo2 TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO8C Q5S007 12 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 10.404 8.367 None -77.76, 115.2 -99.79, 16.57 -70.68, -24.12 178.89, 61.58 -64.22, -41.72 out-out out 11.341 Saltbr-out 7.744 HRD-in -73.07, -35.29 72.76, -10.32 out-out-out SNCooo out-out ActLoopNT-out 9.471 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -67.5, -18.26 APE9-dihe-na 74.89, 160.43 APE8-dihe-in -64.77, 133.4 APE8-rot-in 300.66 APE67-dihe-in -63.6, -35.05 -59.67, -34.64 APE12-dist-in 9.071 APE11-dist-in 10.522 APE10-dist-out 14.411 APE9-dist-in 4.449 None None None EM 3.88 999.0 999.0 C 2527 2270 4 0 0 3 [[1875, 2134]] 1.0 8fo8 TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO8E Q5S007 12 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 10.415 8.349 None -77.68, 115.13 -99.83, 16.55 -70.64, -24.07 178.91, 61.52 -64.18, -41.73 out-out out 11.321 Saltbr-out 7.73 HRD-in -73.0, -35.27 72.87, -10.42 out-out-out SNCooo out-out ActLoopNT-out 9.47 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -67.4, -18.35 APE9-dihe-na 74.93, 160.44 APE8-dihe-in -64.61, 133.34 APE8-rot-in 300.72 APE67-dihe-in -63.56, -35.05 -59.56, -34.8 APE12-dist-in 9.056 APE11-dist-in 10.526 APE10-dist-out 14.406 APE9-dist-in 4.434 None None None EM 3.88 999.0 999.0 E 2527 2270 4 0 0 3 [[1875, 2134]] 1.0 8fo8 TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO9F Q5S007 12 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 9.348 8.575 None -68.36, 152.72 -137.53, 18.95 -81.54, -22.77 187.88, 51.61 -70.19, -36.74 out-out out 11.238 Saltbr-out 8.326 HRD-in -76.93, -42.26 72.06, -11.17 out-out-out SNCooo out-out ActLoopNT-out 9.106 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -70.82, -18.07 APE9-dihe-na 87.94, 175.98 APE8-dihe-in -63.48, 135.16 APE8-rot-in 300.23 APE67-dihe-in -66.37, -45.6 -58.88, -37.04 APE12-dist-in 9.718 APE11-dist-in 10.578 APE10-dist-out 14.122 APE9-dist-in 4.473 None None None EM 3.48 999.0 999.0 F 2527 2289 3 0 0 3 [[1875, 2134]] 1.0 8fo9 TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LI3A Q5S007 558 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 9.583 8.403 None -64.7, 121.5 -105.97, 8.82 -69.04, -26.41 175.66, 65.26 -63.25, -46.61 out-out out 11.401 Saltbr-out 8.121 HRD-in -76.04, -34.97 73.14, -12.04 out-out-out SNCooo out-out ActLoopNT-out 9.664 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -85.32, -9.76 APE9-dihe-na 87.27, 160.92 APE8-dihe-in -56.79, 143.13 APE8-rot-in 300.33 APE67-dihe-in -63.35, -39.62 -56.92, -55.07 APE12-dist-in 10.386 APE11-dist-in 10.363 APE10-dist-out 14.006 APE9-dist-in 3.652 None None None EM 3.8 999.0 999.0 A 2527 1795 3 0 0 3 [[1875, 2134]] 1.0 7li3 TKL_LRRK2_HUMAN TKL 3.9e-56 197.0 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO9E Q5S007 12 2527 2527.0 ATP:2602 ATPlike Inactive DFGout 11.374 7.913 None -68.54, 152.71 -137.53, 21.65 -90.85, -9.64 146.2, 91.59 -82.02, -36.47 out-out out 11.16 Saltbr-out 8.209 HRD-in -76.97, -42.35 72.15, -11.11 out-out-out SNCooo out-out ActLoopNT-out 9.123 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -70.77, -18.05 APE9-dihe-na 87.91, 175.95 APE8-dihe-in -63.49, 135.16 APE8-rot-in 300.24 APE67-dihe-in -66.44, -45.65 -58.78, -37.14 APE12-dist-in 9.651 APE11-dist-in 10.552 APE10-dist-out 14.083 APE9-dist-in 4.472 None None None EM 3.48 999.0 999.0 E 2527 2287 3 0 0 3 [[1875, 2134]] 1.0 8fo9 TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TYR EGFR EGFR_HUMAN 8PO4B P00533 700 1014 1210.0 ATP:1101 ATPlike Inactive DFGin 5.624 16.394 BLBtrans -121.3, 175.63 63.19, 26.9 -63.92, 138.21 163.94, 68.04 83.38, -10.03 out-out out 13.6 Saltbr-out 13.029 HRD-in -73.28, -55.5 80.32, -14.85 out-out-out SNCooo out-out ActLoopNT-out 6.486 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 119.23 APE8-dihe-in -81.98, 63.66 APE8-rot-na 32.98 APE67-dihe-in -71.84, -8.05 -50.66, -40.3 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.255 V948R None None XRAY 1.621 0.211 0.243 B 328 295 20 0 0 13 [[712, 970]] 1.0 8po4 TYR_EGFR_HUMAN TYR 7.9e-88 300.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR INSR INSR_HUMAN 3BU5A P06213 1014 1310 1382.0 ATP:60300 ATPlike Active DFGin 6.659 13.934 BLAminus -128.64, -166.6 44.54, 89.54 -102.81, 23.91 295.82, 99.34 -57.5, -34.18 in-in in 8.261 Saltbr-in 3.13 HRD-in -68.86, -51.91 77.02, -10.33 in-in-in SNCiii in-in ActLoopNT-in 2.844 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.0, 102.51 APE9-dihe-in -127.85, 151.44 APE8-dihe-in -79.76, 69.1 APE8-rot-na 32.47 APE67-dihe-in -66.77, -8.03 -57.27, -41.89 APE12-dist-na 15.937 APE11-dist-na 11.724 APE10-dist-na 11.3 APE9-dist-in 7.401 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 2.1 0.196 0.239 A 306 294 3 0 0 0 [[1023, 1292]] 1.0 3bu5 TYR_INSR_HUMAN TYR 1.3e-96 328.8 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR JAK2-1 JAK2_HUMAN 5I4NA O60674 537 809 1132.0 ATP:61000 ATPlike Pseudo DFGin 5.668 13.386 None -68.19, 172.29 -64.41, 158.19 -73.31, -26.63 342.84, 34.8 77.82, -169.16 out-na out 11.405 Saltbr-na 999.0 HRD-in -78.6, -60.98 86.96, 3.87 na-out-out SNCaoo out-out ActLoopNT-out 8.681 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.12, -41.49 APE9-dihe-out -58.18, -29.35 APE8-dihe-out -88.11, 6.74 APE8-rot-na 290.83 APE67-dihe-out -103.83, 26.01 -65.06, 135.53 APE12-dist-na 10.037 APE11-dist-na 11.7 APE10-dist-na 16.278 APE9-dist-out 12.372 E596A,V617F,W659A,W777A,F794H None None XRAY 1.54 0.174 0.193 A 290 273 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5i4n TYR_JAK2-1_HUMAN TYR 7.1e-64 221.5 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 4FVRA O60674 536 809 1132.0 ATP:901 ATPlike Pseudo DFGin 5.766 13.376 None -77.86, -178.54 -72.61, 163.95 -75.06, -27.39 334.11, 39.64 77.27, -166.65 out-na out 11.782 Saltbr-na 999.0 HRD-in -74.66, -57.27 90.8, -3.55 na-out-out SNCaoo out-out ActLoopNT-out 8.537 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.48, -33.68 APE9-dihe-out -63.8, -34.8 APE8-dihe-out -85.1, 11.44 APE8-rot-na 293.02 APE67-dihe-out -101.64, 24.24 -66.8, 135.55 APE12-dist-na 9.675 APE11-dist-na 11.473 APE10-dist-na 16.037 APE9-dist-out 12.028 V617F,W777A,F794H None None XRAY 2.0 0.183 0.229 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4fvr TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 4FVQA O60674 536 809 1132.0 ATP:901 ATPlike Pseudo DFGin 6.411 13.531 None -82.38, -178.3 -71.29, 157.18 -64.23, -31.16 342.38, 32.32 77.45, -167.94 out-na out 10.357 Saltbr-na 999.0 HRD-in -81.79, -59.57 93.66, -10.87 na-out-out SNCaoo out-out ActLoopNT-out 9.094 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.14, -35.28 APE9-dihe-out -67.39, -22.98 APE8-dihe-out -92.26, 6.93 APE8-rot-na 290.03 APE67-dihe-out -106.47, 27.81 -64.4, 133.6 APE12-dist-na 9.912 APE11-dist-na 11.487 APE10-dist-na 16.075 APE9-dist-out 12.378 W659A,W777A,F794H None None XRAY 1.75 0.176 0.199 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4fvq TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C08A O60674 537 810 1132.0 ATP:901 ATPlike Pseudo DFGin 6.598 13.736 None -72.21, 176.69 -66.6, 164.57 -72.8, -15.2 349.18, 27.02 73.34, -163.25 in-na in 9.4 Saltbr-na 999.0 HRD-in -80.72, -74.63 111.24, -16.83 na-out-out SNCaoo out-out ActLoopNT-out 9.474 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -55.86, -37.52 APE9-dihe-out -72.05, -28.92 APE8-dihe-out -74.69, -10.21 APE8-rot-na 283.12 APE67-dihe-out -93.42, 18.23 -54.81, 139.34 APE12-dist-na 9.92 APE11-dist-na 11.859 APE10-dist-na 16.352 APE9-dist-out 12.53 W659A,W777A,F794H None None XRAY 2.2 0.267 0.259 A 289 270 4 0 0 0 [[545, 807], [849, 1125]] 2.0 8c08 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C08B O60674 536 810 1132.0 ATP:901 ATPlike Pseudo DFGin 5.646 13.539 None -63.04, -178.12 -72.48, 164.14 -59.19, -39.37 337.51, 34.58 89.58, -173.09 out-na out 12.178 Saltbr-na 999.0 HRD-in -76.08, -63.96 89.49, 0.26 na-out-out SNCaoo out-out ActLoopNT-out 8.73 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.09, -36.29 APE9-dihe-out -67.21, -14.45 APE8-dihe-out -97.09, 0.9 APE8-rot-na 279.42 APE67-dihe-out -95.31, 21.21 -63.75, 135.54 APE12-dist-na 10.848 APE11-dist-na 11.837 APE10-dist-na 16.6 APE9-dist-out 12.658 W659A,W777A,F794H None None XRAY 2.2 0.267 0.259 B 289 269 6 0 0 0 [[545, 807], [849, 1125]] 2.0 8c08 TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR MET MET_HUMAN 3DKCA P08581 1051 1360 1390.0 ATP:60001 ATPlike Inactive DFGin 5.693 13.103 BLBplus -128.11, 162.74 67.51, 17.44 -61.67, 130.17 44.2, 92.69 80.08, -22.94 out-out out 14.083 Saltbr-out 12.836 HRD-in -71.17, -57.45 82.5, -22.81 out-out-out SNCooo out-out ActLoopNT-out 7.739 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -83.24, -9.16 APE9-dihe-in -104.14, 150.23 APE8-dihe-in -75.82, 62.17 APE8-rot-na 30.64 APE67-dihe-in -64.7, -18.65 -61.74, -26.11 APE12-dist-na 18.53 APE11-dist-na 20.199 APE10-dist-na 15.662 APE9-dist-out 9.072 Y1194F,Y1234F,Y1235D None None XRAY 1.52 0.189 0.218 A 317 310 0 0 0 0 [[1078, 1339]] 1.0 3dkc TYR_MET_HUMAN TYR 8.6e-90 306.9 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR PTK2 FAK1_HUMAN 2IJMA Q05397 414 688 1052.0 ATP:690 ATPlike Inactive DFGin 5.335 15.255 None -130.4, -10.41 -96.6, 92.35 -115.09, 154.36 308.92, 97.78 84.66, -9.12 in-in in 7.602 Saltbr-in 2.544 HRD-in -77.84, -47.69 90.07, -21.21 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -43.55 APE8-dihe-in -70.98, 54.52 APE8-rot-na 26.91 APE67-dihe-in -71.31, -14.5 -49.75, -42.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.531 None None None XRAY 2.187 0.211 0.271 A 281 260 15 0 0 15 [[422, 678]] 1.0 2ijm TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1

Ligand: ATP

Total number of chains: 240
Active chains: 98
Total number of genes: 51
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 156 65.0% 5LVOA
DFGin None 24 10.0% 5I4NA
DFGin BLBplus 23 9.6% 3DKCA
DFGinter None 14 5.8% 9D5IA
DFGin BLBtrans 8 3.3% 1HCKA
DFGin ABAminus 6 2.5% 7T4TA
None None 5 2.1% 4FI1A
DFGin BLBminus 3 1.2% 7Z9TBBB
DFGout None 1 0.4% 8FO9E
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL BRI1 BRI1_ARATH 5LPYA O22476 867 1160 1196.0 ATP:1200 ATPlike Active DFGin 5.175 15.203 BLAminus -134.16, 179.9 60.37, 82.56 -100.0, 17.51 285.92, 71.71 -57.07, -20.27 in-in in 8.892 Saltbr-in 3.152 HRD-in -70.7, -49.88 77.86, -1.82 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.47, 151.76 APE9-dihe-na 140.48, 176.99 APE8-dihe-in -121.99, 138.13 APE8-rot-in 307.91 APE67-dihe-inflip 92.03, -10.16 -52.79, 133.04 APE12-dist-in 9.609 APE11-dist-in 11.524 APE10-dist-in 5.721 APE9-dist-in 3.885 T872A TPO1039,SEP1042,SEP1044,SEP1060 TPO1039,SEP1042,SEP1044,SEP1060 XRAY 2.3 0.203 0.248 A 296 286 8 0 0 0 [[882, 1157]] 1.0 5lpy Arabidopsis thaliana TKL_BRI1_ARATH TKL 2e-63 220.4 4 266 263 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL FERONIA FERON_ARATH 7XDVA Q9SCZ4 521 815 895.0 ATP:60401 ATPlike None DFGin 6.699 15.572 BLAminus -134.27, 177.47 68.35, 79.21 -98.58, 11.5 282.56, 76.24 -59.84, -20.83 in-none in 8.723 Saltbr-none 999.0 HRD-in -67.4, -48.26 73.32, 1.35 none-in-none SNCnin in-none ActLoopNT-in 2.905 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 147.64 APE8-rot-in 320.48 APE67-dihe-in -72.12, 2.13 -58.53, -58.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.97 0.172 0.213 A 313 283 12 0 0 12 [[535, 809]] 1.0 7xdv Arabidopsis thaliana TKL_FERONIA_ARATH TKL 8.2e-57 198.7 3 266 264 678 679 680 682 684 565 581 585 658 660 659 661 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
TKL FERONIA FERON_ARATH 7XDVB Q9SCZ4 522 816 895.0 ATP:60401 ATPlike None DFGin 6.676 15.7 BLAminus -133.75, 179.29 66.82, 78.34 -97.78, 11.62 279.93, 76.8 -60.95, -21.55 in-none in 8.917 Saltbr-none 999.0 HRD-in -65.85, -46.61 72.82, 0.74 none-in-none SNCnin in-none ActLoopNT-in 2.856 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 149.11 APE8-rot-in 319.48 APE67-dihe-in -72.05, 2.55 -59.63, -58.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.97 0.172 0.213 B 313 283 12 0 0 12 [[535, 809]] 1.0 7xdv Arabidopsis thaliana TKL_FERONIA_ARATH TKL 8.2e-57 198.7 3 266 264 678 679 680 682 684 565 581 585 658 660 659 661 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
OTHER LANKC A0A6H0TJ16_BACTU 8SAMA A0A6H0TJ16 1 862 872.0 ATP:60902 ATPlike None DFGin 6.64 14.881 BLAminus -119.81, 176.45 65.16, 86.81 -107.13, 32.95 280.75, 71.48 -74.73, -19.84 in-in in 7.41 Saltbr-in 2.775 HRD-na-- -76.54, -26.64 101.12, -25.28 in-in-none SNCiin in-none ActLoopNT-in 2.75 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.15 0.205 0.251 A 904 845 0 0 0 0 [[228, 410]] 1.0 8sam Bacillus thuringiensis serovar andalousiensis OTHER_LANKC_BACTU CAMK 1.4e-13 57.3 1 164 164 381 382 383 385 387 257 279 283 361 363 362 364 0 0 0 0 0 0 0 0 0 310 Class III lanthionine synthetase LanKC
OTHER LANKC A0A6H0TJ16_BACTU 8SAMB A0A6H0TJ16 1 862 872.0 ATP:60901 ATPlike Inactive DFGin 6.749 15.009 BLAminus -116.86, 172.09 66.52, 88.25 -108.59, 34.42 278.94, 73.78 -73.89, -19.99 in-out in 7.479 Saltbr-out 3.865 HRD-na-- -85.28, 118.03 -78.23, 6.03 out-in-none SNCoin in-none ActLoopNT-in 2.764 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.15 0.205 0.251 B 904 844 0 0 0 0 [[228, 410]] 1.0 8sam Bacillus thuringiensis serovar andalousiensis OTHER_LANKC_BACTU CAMK 1.4e-13 57.3 1 164 164 381 382 383 385 387 257 279 283 361 363 362 364 0 0 0 0 0 0 0 0 0 310 Class III lanthionine synthetase LanKC
AGC GRK1 GRK1_BOVIN 3T8OA P28327 30 532 561.0 ATP:562 ATPlike Active DFGin 6.784 13.652 BLAminus -147.61, 176.5 66.51, 86.5 -106.39, 20.07 278.45, 121.96 -78.51, -8.51 in-in in 9.131 Saltbr-in 2.946 HRD-in -72.08, -59.57 74.93, 15.13 in-in-in SNCiii in-in ActLoopNT-in 3.034 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.6, 145.4 APE9-dihe-na 140.82, -165.62 APE8-dihe-in -114.33, 123.31 APE8-rot-in 302.45 APE67-dihe-inflip 90.49, -9.25 -48.36, 136.06 APE12-dist-in 10.419 APE11-dist-in 11.645 APE10-dist-in 5.795 APE9-dist-in 4.276 L166K None None XRAY 2.5 0.209 0.245 A 543 493 0 0 0 0 [[187, 452]] 1.0 3t8o Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C4WA P28327 31 533 561.0 ATP:562 ATPlike Active DFGin 6.587 13.314 BLAminus -157.51, 175.0 67.79, 80.23 -106.97, 21.1 277.77, 138.55 -72.95, -18.52 in-in in 8.671 Saltbr-in 2.659 HRD-in -67.86, -51.97 60.46, 12.85 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.73, 153.77 APE9-dihe-na 125.45, -175.95 APE8-dihe-in -101.44, 127.92 APE8-rot-in 301.93 APE67-dihe-inflip 97.46, -21.92 -46.81, 133.28 APE12-dist-in 10.007 APE11-dist-in 11.248 APE10-dist-in 5.534 APE9-dist-in 3.508 None TPO8 TPO8 XRAY 2.7 0.192 999.0 A 543 494 0 0 0 0 [[187, 452]] 1.0 3c4w Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C4WB P28327 5 533 561.0 ATP:562 ATPlike Active DFGin 5.963 13.111 BLAminus -155.04, 178.49 64.64, 79.84 -103.28, 19.03 277.57, 109.21 -72.3, -19.68 in-in in 8.548 Saltbr-in 2.84 HRD-in -67.79, -54.67 64.69, 11.83 in-in-in SNCiii in-in ActLoopNT-in 2.958 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.45, 154.48 APE9-dihe-na 126.08, -175.35 APE8-dihe-in -101.18, 126.91 APE8-rot-in 300.91 APE67-dihe-inflip 94.23, -17.08 -47.18, 130.86 APE12-dist-in 10.103 APE11-dist-in 11.254 APE10-dist-in 5.545 APE9-dist-in 3.534 None TPO8 TPO8 XRAY 2.7 0.192 999.0 B 543 519 0 0 0 0 [[187, 452]] 1.0 3c4w Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C4XA P28327 30 533 561.0 ATP:562 ATPlike Active DFGin 6.392 13.294 BLAminus -153.36, -178.73 56.38, 83.66 -101.23, 19.01 282.86, 141.85 -58.01, -33.04 in-in in 8.623 Saltbr-in 2.825 HRD-in -65.41, -52.58 62.44, 13.36 in-in-in SNCiii in-in ActLoopNT-in 2.96 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -170.48, 144.22 APE9-dihe-na 128.55, -174.69 APE8-dihe-in -103.7, 129.98 APE8-rot-in 314.1 APE67-dihe-inflip 101.04, -22.84 -50.28, 132.61 APE12-dist-in 10.283 APE11-dist-in 11.237 APE10-dist-in 5.726 APE9-dist-in 3.827 None None None XRAY 2.9 0.193 999.0 A 543 496 0 0 0 0 [[187, 452]] 1.0 3c4x Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C4XB P28327 31 533 561.0 ATP:562 ATPlike Active DFGin 5.903 13.063 BLAminus -149.62, 174.69 57.3, 76.73 -95.24, 8.98 282.05, 96.12 -51.11, -35.54 in-in in 8.642 Saltbr-in 2.675 HRD-in -62.32, -48.48 63.55, 4.44 in-in-in SNCiii in-in ActLoopNT-in 3.043 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.42, 143.72 APE9-dihe-na 129.46, -175.16 APE8-dihe-in -98.28, 125.3 APE8-rot-in 312.69 APE67-dihe-inflip 98.15, -18.1 -45.11, 129.51 APE12-dist-in 10.201 APE11-dist-in 11.247 APE10-dist-in 5.61 APE9-dist-in 3.639 None None None XRAY 2.9 0.193 999.0 B 543 475 0 0 0 0 [[187, 452]] 1.0 3c4x Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC PRKACA KAPCA_BOVIN 9DW9G P00517 13 351 351.0 ATP:401 ATPlike Active DFGin 6.569 15.126 BLAminus -133.9, -169.96 59.46, 64.31 -83.85, 33.99 275.29, 73.58 -66.33, -24.36 in-in in 9.499 Saltbr-in 3.217 HRD-in -92.3, -53.34 68.25, 14.14 in-in-in SNCiii in-in ActLoopNT-in 3.08 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.91, 151.76 APE9-dihe-na 126.66, -174.62 APE8-dihe-in -92.84, 130.69 APE8-rot-in 299.41 APE67-dihe-in -68.55, -23.13 -58.33, -34.44 APE12-dist-in 8.703 APE11-dist-in 11.563 APE10-dist-in 6.17 APE9-dist-in 4.568 None TPO198 TPO198 EM 2.8 999.0 999.0 G 351 328 0 0 0 0 [[44, 298]] 1.0 9dw9 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1Q24A P00517 15 351 351.0 ATP:60400 ATPlike Active DFGin 5.983 14.319 BLAminus -113.95, 178.0 66.86, 85.15 -103.99, 32.82 274.7, 64.8 -65.44, -25.66 in-in in 8.779 Saltbr-in 2.742 HRD-in -93.22, -55.61 73.46, 14.95 in-in-in SNCiii in-in ActLoopNT-in 3.09 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.66, 162.77 APE9-dihe-na 133.15, -143.39 APE8-dihe-in -135.22, 127.61 APE8-rot-in 301.89 APE67-dihe-in -67.43, -30.61 -42.63, -46.05 APE12-dist-in 8.036 APE11-dist-in 11.447 APE10-dist-in 6.024 APE9-dist-in 3.486 V124A,L174M TPO198,SEP339 TPO198,SEP339 XRAY 2.6 0.202 0.25 A 350 337 0 0 0 0 [[44, 298]] 1.0 1q24 Bos taurus AGC_PRKACA_BOVIN AGC 4.8e-94 320.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
OTHER PAN3 PAN3_CHATD 4CYIA G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.585 12.852 None -92.38, -13.16 -130.85, 61.75 -94.99, 144.51 286.93, 999.0 79.52, -4.52 out-na out 13.591 Saltbr-na 999.0 HRD-out -83.98, 84.54 -50.92, -35.91 na-out-na SNCaoa out-na ActLoopNT-out 7.062 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -80.88, -42.8 APE9-dihe-na -64.32, -40.93 APE8-dihe-na -99.24, 17.32 APE8-rot-na 300.48 APE67-dihe-na -73.05, -48.17 -58.31, -53.55 APE12-dist-na 4.897 APE11-dist-na 5.543 APE10-dist-na 5.105 APE9-dist-na 11.572 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 A 438 405 0 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIB G0S0Y3 213 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.616 12.918 None -91.62, -15.83 -130.65, 63.54 -94.89, 145.11 286.33, 999.0 77.48, -4.88 out-na out 13.58 Saltbr-na 999.0 HRD-out -84.8, 85.11 -51.08, -35.56 na-out-na SNCaoa out-na ActLoopNT-out 7.175 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -82.17, -41.93 APE9-dihe-na -64.26, -40.58 APE8-dihe-na -98.12, 16.28 APE8-rot-na 298.69 APE67-dihe-na 80.12, -45.62 -60.06, 122.74 APE12-dist-na 4.893 APE11-dist-na 5.478 APE10-dist-na 5.079 APE9-dist-na 11.87 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 B 438 406 8 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIC G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.492 12.647 None -89.83, -13.71 -129.71, 95.5 -125.66, 144.13 285.48, 999.0 76.65, -4.79 out-na out 13.568 Saltbr-na 999.0 HRD-out -84.9, 84.38 -51.27, -35.99 na-out-na SNCaoa out-na ActLoopNT-out 7.036 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.46, -42.97 APE9-dihe-na -65.29, -40.87 APE8-dihe-na -98.03, 18.1 APE8-rot-na 300.5 APE67-dihe-na -80.64, -42.62 -57.0, -52.24 APE12-dist-na 4.87 APE11-dist-na 5.412 APE10-dist-na 5.104 APE9-dist-na 11.702 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 C 438 397 8 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYID G0S0Y3 214 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.581 12.83 None -92.56, -14.61 -129.54, 61.33 -91.03, 145.16 286.17, 999.0 78.34, -3.87 out-na out 13.632 Saltbr-na 999.0 HRD-out -84.73, 84.5 -51.45, -36.17 na-out-na SNCaoa out-na ActLoopNT-out 6.98 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -82.5, -42.63 APE9-dihe-na -63.84, -39.93 APE8-dihe-na -97.69, 15.27 APE8-rot-na 300.06 APE67-dihe-na 82.88, -51.63 -61.5, 124.95 APE12-dist-na 4.849 APE11-dist-na 5.59 APE10-dist-na 5.161 APE9-dist-na 11.613 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 D 438 407 8 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIE G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.538 12.767 None -90.87, -14.73 -130.14, 65.48 -95.4, 143.11 286.9, 999.0 77.19, -4.14 out-na out 13.933 Saltbr-na 999.0 HRD-out -83.54, 85.23 -50.62, -36.04 na-out-na SNCaoa out-na ActLoopNT-out 6.962 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.29, -42.51 APE9-dihe-na -65.13, -42.05 APE8-dihe-na -99.46, 17.91 APE8-rot-na 300.53 APE67-dihe-na -82.88, -16.1 -58.82, -52.89 APE12-dist-na 4.867 APE11-dist-na 5.506 APE10-dist-na 4.99 APE9-dist-na 11.652 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 E 438 394 10 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIF G0S0Y3 213 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.657 12.928 None -90.71, -14.62 -131.6, 64.5 -94.2, 145.33 287.42, 999.0 78.97, -5.05 out-na out 13.619 Saltbr-na 999.0 HRD-out -84.32, 83.81 -51.72, -36.16 na-out-na SNCaoa out-na ActLoopNT-out 7.068 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.37, -43.07 APE9-dihe-na -65.03, -40.26 APE8-dihe-na -97.58, 14.32 APE8-rot-na 301.7 APE67-dihe-na 82.79, -63.67 -61.76, 133.26 APE12-dist-na 4.897 APE11-dist-na 5.471 APE10-dist-na 4.981 APE9-dist-na 11.745 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 F 438 408 8 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIG G0S0Y3 212 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.345 12.727 None -90.69, -14.9 -130.76, 66.96 -94.98, 143.34 287.45, 999.0 77.29, -3.15 out-na out 13.686 Saltbr-na 999.0 HRD-out -84.86, 86.26 -50.94, -35.45 na-out-na SNCaoa out-na ActLoopNT-out 6.956 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.27, -42.88 APE9-dihe-na -64.53, -40.74 APE8-dihe-na -98.57, 20.38 APE8-rot-na 300.7 APE67-dihe-na -82.95, -50.87 -54.99, -52.34 APE12-dist-na 4.886 APE11-dist-na 5.441 APE10-dist-na 4.99 APE9-dist-na 11.838 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 G 438 397 11 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIH G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.548 12.993 None -92.58, -12.35 -130.21, 41.87 -74.5, 144.28 287.27, 999.0 78.55, -5.47 out-na out 13.565 Saltbr-na 999.0 HRD-out -84.2, 83.95 -50.63, -35.15 na-out-na SNCaoa out-na ActLoopNT-out 7.113 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.74, -43.44 APE9-dihe-na -64.3, -40.98 APE8-dihe-na -98.31, 13.33 APE8-rot-na 300.84 APE67-dihe-na 84.19, -53.66 -61.5, 130.17 APE12-dist-na 4.897 APE11-dist-na 5.551 APE10-dist-na 5.004 APE9-dist-na 11.679 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 H 438 407 7 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJA G0S0Y3 207 630 640.0 ATP:900 ATPlike Pseudo DFGin 8.634 13.143 None -107.98, -0.69 -128.2, 34.36 -65.03, -50.53 266.85, 999.0 -67.72, -27.44 out-na out 13.824 Saltbr-na 999.0 HRD-out -72.25, 117.57 -98.06, -29.9 na-out-na SNCaoa out-na ActLoopNT-out 6.734 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -76.94, -48.66 APE9-dihe-na -63.83, -32.83 APE8-dihe-na -105.44, 19.22 APE8-rot-na 294.5 APE67-dihe-na -75.63, -42.57 -53.51, -50.74 APE12-dist-na 4.896 APE11-dist-na 5.565 APE10-dist-na 4.767 APE9-dist-na 12.093 None None None XRAY 2.59 0.185 0.221 A 438 403 9 0 0 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJB G0S0Y3 207 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.657 13.407 None -109.51, -3.14 -128.47, 33.06 -65.31, -51.07 267.08, 999.0 -68.09, -25.9 out-na out 13.607 Saltbr-na 999.0 HRD-out -72.34, 112.57 -93.58, -28.7 na-out-na SNCaoa out-na ActLoopNT-out 6.74 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.81, -47.86 APE9-dihe-na -64.66, -32.92 APE8-dihe-na -101.7, 13.23 APE8-rot-na 292.51 APE67-dihe-na 83.46, -7.05 -62.34, 118.45 APE12-dist-na 4.827 APE11-dist-na 5.687 APE10-dist-na 4.961 APE9-dist-na 11.892 None None None XRAY 2.59 0.185 0.221 B 438 412 10 0 0 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJC G0S0Y3 210 632 640.0 ATP:900 ATPlike Pseudo DFGin 8.673 13.164 None -108.29, -3.21 -129.06, 34.16 -64.55, -50.26 267.61, 999.0 -68.23, -27.03 out-na out 13.722 Saltbr-na 999.0 HRD-out -71.32, 109.68 -92.82, -27.84 na-out-na SNCaoa out-na ActLoopNT-out 6.928 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -75.12, -48.05 APE9-dihe-na -64.49, -35.42 APE8-dihe-na -104.77, 18.2 APE8-rot-na 294.69 APE67-dihe-na -54.66, -46.82 -53.38, -67.98 APE12-dist-na 4.886 APE11-dist-na 5.663 APE10-dist-na 4.931 APE9-dist-na 11.895 None None None XRAY 2.59 0.185 0.221 C 438 404 8 0 0 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJD G0S0Y3 207 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.73 13.246 None -109.91, -2.89 -127.7, 32.83 -63.98, -50.83 267.28, 999.0 -68.06, -27.82 out-na out 13.683 Saltbr-na 999.0 HRD-out -71.89, 115.33 -92.98, -30.13 na-out-na SNCaoa out-na ActLoopNT-out 6.66 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.1, -45.9 APE9-dihe-na -60.82, -48.55 APE8-dihe-na -95.53, 14.82 APE8-rot-na 272.71 APE67-dihe-na -68.99, -42.68 -59.32, -45.4 APE12-dist-na 4.893 APE11-dist-na 5.689 APE10-dist-na 4.875 APE9-dist-na 11.937 None None None XRAY 2.59 0.185 0.221 D 438 411 11 0 0 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
AGC PRKACA KAPCA_CRIGR 6EMAA P25321 12 351 351.0 ATP:60401 ATPlike Active DFGin 6.847 14.028 BLAminus -121.3, 163.01 76.03, 95.19 -107.48, 29.41 285.05, 72.84 -63.27, -23.25 in-in in 8.581 Saltbr-in 2.912 HRD-in -88.06, -51.23 73.05, 9.34 in-in-in SNCiii in-in ActLoopNT-in 2.843 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.85, 162.03 APE9-dihe-na 127.51, -167.2 APE8-dihe-in -113.51, 133.85 APE8-rot-in 299.54 APE67-dihe-in -58.99, -24.47 -49.7, -50.19 APE12-dist-in 8.208 APE11-dist-in 11.434 APE10-dist-in 5.777 APE9-dist-in 3.585 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.88 0.184 0.213 A 353 340 0 0 0 0 [[44, 298]] 1.0 6ema Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6Y8CA P25321 13 351 351.0 ATP:60402 ATPlike Active DFGin 5.727 14.302 BLAminus -123.99, 172.57 69.5, 82.73 -92.15, 25.74 279.44, 63.0 -58.78, -31.82 in-in in 9.166 Saltbr-in 2.638 HRD-in -96.49, -52.39 69.1, 12.65 in-in-in SNCiii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.28, 160.42 APE9-dihe-na 122.78, -169.96 APE8-dihe-in -106.17, 134.07 APE8-rot-in 304.81 APE67-dihe-in -60.24, -22.7 -48.33, -48.43 APE12-dist-in 8.044 APE11-dist-in 11.517 APE10-dist-in 5.939 APE9-dist-in 3.895 None TPO198,SEP339 TPO198,SEP339 XRAY 1.76 0.162 0.19 A 353 339 0 0 0 0 [[44, 298]] 1.0 6y8c Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC GRK5 GRK5_HUMAN 9CKRA P34947 25 542 590.0 ATP:603 ATPlike Active DFGin 6.172 12.867 BLAminus -123.04, 159.77 67.48, 80.75 -99.52, 5.04 278.7, 83.61 -52.63, -21.44 in-in in 8.589 Saltbr-in 3.447 HRD-in -94.88, -52.49 68.7, 5.59 in-in-in SNCiii in-in ActLoopNT-in 2.968 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.66, 167.59 APE9-dihe-na 129.66, -152.54 APE8-dihe-in -119.66, 138.17 APE8-rot-in 320.31 APE67-dihe-inflip 80.19, -6.12 -54.38, 134.58 APE12-dist-in 9.872 APE11-dist-in 12.258 APE10-dist-in 6.529 APE9-dist-in 4.181 D311N None None XRAY 2.8 0.239 0.286 A 598 501 0 0 0 0 [[186, 448]] 1.0 9ckr Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC GRK5 GRK5_HUMAN 9CKSA P34947 25 542 590.0 ATP:603 ATPlike Active DFGin 6.038 13.061 BLAminus -123.04, 167.6 79.98, 56.79 -87.17, 17.84 285.5, 62.72 -70.38, -31.79 in-in in 9.222 Saltbr-in 2.672 HRD-in -92.29, -53.7 68.73, 3.48 in-in-in SNCiii in-in ActLoopNT-in 2.963 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.24, 151.24 APE9-dihe-na 138.17, -158.29 APE8-dihe-in -117.35, 145.2 APE8-rot-in 310.61 APE67-dihe-inflip 85.98, -22.04 -53.6, 135.84 APE12-dist-in 10.616 APE11-dist-in 12.407 APE10-dist-in 6.563 APE9-dist-in 4.207 D311N None None XRAY 3.08 0.228 0.28 A 598 501 0 0 0 0 [[186, 448]] 1.0 9cks Homo sapiens AGC_GRK5_HUMAN AGC 7.6e-83 283.7 1 260 260 328 329 330 332 334 215 234 238 308 310 309 311 367 355 350 349 348 347 346 345 344 264 G protein-coupled receptor kinase 5
AGC PDPK1 PDPK1_HUMAN 1H1WA O15530 71 359 556.0 ATP:1373 ATPlike Inactive DFGin 6.612 14.931 BLAminus -145.26, -169.97 71.92, 72.18 -105.82, -0.04 289.27, 102.08 -58.33, -31.92 in-in in 8.581 Saltbr-in 2.71 HRD-in -71.45, -48.32 74.08, -8.04 in-in-out SNCiio in-out ActLoopNT-in 2.84 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -131.69, 112.94 APE9-dihe-na -63.98, -168.66 APE8-dihe-in -54.13, 124.0 APE8-rot-in 301.59 APE67-dihe-in -62.54, -19.03 -38.83, -50.46 APE12-dist-in 8.922 APE11-dist-out 5.528 APE10-dist-out 10.298 APE9-dist-in 3.799 None SEP241 SEP241 XRAY 2.0 0.196 0.223 A 289 285 4 0 0 4 [[82, 342]] 1.0 1h1w Homo sapiens AGC_PDPK1_HUMAN AGC 9.8e-85 289.7 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 2BIYA O15530 72 359 556.0 ATP:1373 ATPlike Active DFGin 6.619 15.095 BLAminus -141.33, -175.84 82.91, 67.67 -104.99, 1.58 283.05, 104.18 -61.63, -33.06 in-in in 8.673 Saltbr-in 2.575 HRD-in -63.52, -52.73 78.44, -11.09 in-in-in SNCiii in-in ActLoopNT-in 2.82 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -88.22, 130.12 APE9-dihe-na 106.71, 171.13 APE8-dihe-in -96.94, 126.07 APE8-rot-in 299.07 APE67-dihe-in -62.15, -19.51 -52.23, -44.36 APE12-dist-in 12.868 APE11-dist-in 12.869 APE10-dist-in 7.268 APE9-dist-in 4.745 S241A None None XRAY 1.95 0.186 0.23 A 310 288 0 0 0 0 [[82, 342]] 1.0 2biy Homo sapiens AGC_PDPK1_HUMAN AGC 1.8e-84 288.8 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3HRCA O15530 76 359 556.0 ATP:1373 ATPlike Active DFGin 6.486 14.833 BLAminus -136.91, -178.17 71.81, 74.55 -104.54, 6.98 286.89, 102.51 -65.47, -24.41 in-in in 8.421 Saltbr-in 3.159 HRD-in -77.24, -54.93 76.93, -11.42 in-in-in SNCiii in-in ActLoopNT-in 2.87 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.25, 162.0 APE9-dihe-na 130.63, -171.63 APE8-dihe-in -125.01, 129.68 APE8-rot-in 292.48 APE67-dihe-in -58.92, -25.29 -45.32, -48.7 APE12-dist-in 7.409 APE11-dist-in 10.582 APE10-dist-in 4.926 APE9-dist-in 3.479 Y288G,Q292A SEP241 SEP241 XRAY 1.91 0.182 0.207 A 311 280 4 0 0 4 [[82, 342]] 1.0 3hrc Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4RRVA O15530 76 359 556.0 ATP:60401 ATPlike Active DFGin 6.548 14.998 BLAminus -136.55, -175.99 74.63, 72.8 -106.52, 5.78 286.61, 100.18 -68.12, -17.88 in-in in 8.52 Saltbr-in 2.956 HRD-in -71.77, -54.29 78.75, -11.73 in-in-in SNCiii in-in ActLoopNT-in 2.938 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.13, 162.83 APE9-dihe-na 132.08, -169.67 APE8-dihe-in -127.24, 132.02 APE8-rot-in 298.33 APE67-dihe-in -59.21, -24.3 -51.83, -46.04 APE12-dist-in 7.281 APE11-dist-in 10.502 APE10-dist-in 4.943 APE9-dist-in 3.569 Y288G,Q292A SEP241 SEP241 XRAY 1.412 0.135 0.163 A 311 284 0 0 0 0 [[82, 342]] 1.0 4rrv Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5ACKA O15530 73 359 556.0 ATP:500 ATPlike Active DFGin 6.615 14.861 BLAminus -135.34, 179.84 72.22, 79.01 -106.01, 4.14 287.93, 97.64 -67.02, -18.73 in-in in 8.418 Saltbr-in 2.583 HRD-in -74.68, -53.67 78.01, -12.73 in-in-in SNCiii in-in ActLoopNT-in 2.906 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.4, 162.51 APE9-dihe-na 136.44, -168.07 APE8-dihe-in -132.35, 133.52 APE8-rot-in 296.36 APE67-dihe-in -62.96, -23.95 -54.34, -43.19 APE12-dist-in 7.326 APE11-dist-in 10.522 APE10-dist-in 4.978 APE9-dist-in 3.558 Y288G,Q292A SEP241 SEP241 XRAY 1.24 0.143 0.166 A 311 287 0 0 0 0 [[82, 342]] 1.0 5ack Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVPA O15530 75 359 556.0 ATP:500 ATPlike Active DFGin 6.303 14.998 BLAminus -144.92, -168.82 66.06, 77.78 -108.23, 11.17 281.99, 93.22 -63.04, -32.41 in-in in 9.539 Saltbr-in 3.158 HRD-in -77.47, -51.83 79.92, -12.48 in-in-in SNCiii in-in ActLoopNT-in 2.848 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.64, 166.02 APE9-dihe-na 141.61, 177.5 APE8-dihe-in -123.02, 134.29 APE8-rot-in 296.02 APE67-dihe-in -68.65, -16.53 -46.89, -50.92 APE12-dist-in 7.907 APE11-dist-in 10.671 APE10-dist-in 5.166 APE9-dist-in 3.705 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 A 311 276 9 0 0 9 [[82, 342]] 1.0 5lvp Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVPB O15530 74 359 556.0 ATP:401 ATPlike Active DFGin 6.328 14.55 BLAminus -137.23, -179.71 80.14, 74.16 -105.47, 15.38 295.0, 84.83 -59.91, -31.47 in-in in 9.274 Saltbr-in 3.302 HRD-in -80.68, -44.41 73.96, -16.23 in-in-in SNCiii in-in ActLoopNT-in 2.744 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.8, 152.43 APE9-dihe-na 134.43, -173.75 APE8-dihe-in -120.09, 128.28 APE8-rot-in 302.93 APE67-dihe-in -67.56, -25.72 -44.99, -47.55 APE12-dist-in 7.872 APE11-dist-in 11.011 APE10-dist-in 5.375 APE9-dist-in 3.787 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 B 311 277 9 0 0 9 [[82, 342]] 1.0 5lvp Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVPC O15530 75 359 556.0 ATP:401 ATPlike Active DFGin 6.391 14.608 BLAminus -132.15, -176.81 71.98, 84.02 -116.53, 7.62 291.47, 90.46 -60.24, -24.5 in-in in 9.304 Saltbr-in 3.087 HRD-in -75.92, -52.06 78.45, -5.49 in-in-in SNCiii in-in ActLoopNT-in 2.823 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -113.81, 168.64 APE9-dihe-na 131.92, -176.79 APE8-dihe-in -126.79, 133.21 APE8-rot-in 299.13 APE67-dihe-in -67.64, -15.8 -51.62, -50.49 APE12-dist-in 7.652 APE11-dist-in 10.863 APE10-dist-in 5.123 APE9-dist-in 3.645 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 C 311 276 9 0 0 9 [[82, 342]] 1.0 5lvp Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVPD O15530 74 359 556.0 ATP:500 ATPlike Active DFGin 6.334 14.433 BLAminus -146.99, -174.22 74.22, 81.56 -113.84, 4.02 287.97, 93.59 -56.11, -25.73 in-in in 9.304 Saltbr-in 3.252 HRD-in -82.38, -50.18 78.4, -12.51 in-in-in SNCiii in-in ActLoopNT-in 2.836 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.65, 165.17 APE9-dihe-na 129.1, -166.82 APE8-dihe-in -132.84, 129.79 APE8-rot-in 300.06 APE67-dihe-in -65.46, -17.03 -48.9, -48.47 APE12-dist-in 8.228 APE11-dist-in 10.891 APE10-dist-in 5.348 APE9-dist-in 3.646 Y288G,Q292A SEP241 SEP241 XRAY 2.5 0.176 0.226 D 311 277 9 0 0 9 [[82, 342]] 1.0 5lvp Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4CT2A O15530 75 359 556.0 ATP:500 ATPlike Active DFGin 6.551 14.867 BLAminus -136.23, -174.98 70.54, 70.07 -102.02, 6.41 290.69, 95.78 -63.73, -21.59 in-in in 8.252 Saltbr-in 2.643 HRD-in -73.2, -54.84 77.37, -9.78 in-in-in SNCiii in-in ActLoopNT-in 2.965 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.02, 163.59 APE9-dihe-na 137.39, -170.05 APE8-dihe-in -132.12, 131.72 APE8-rot-in 295.26 APE67-dihe-in -63.06, -17.27 -51.84, -45.87 APE12-dist-in 7.163 APE11-dist-in 10.524 APE10-dist-in 4.979 APE9-dist-in 3.527 L113V,I118V,I119H,V124I,T128Q,R131K,T148C,F157L,Y288G,Q292A SEP241 SEP241 XRAY 1.25 0.194 0.226 A 311 280 5 0 0 0 [[82, 342]] 1.0 4ct2 Homo sapiens AGC_PDPK1_HUMAN AGC 9.5e-84 286.4 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5MRDA O15530 76 359 556.0 ATP:405 ATPlike Active DFGin 6.429 14.7 BLAminus -133.69, -177.11 74.21, 73.9 -105.88, 9.0 289.39, 99.64 -68.32, -19.62 in-in in 8.346 Saltbr-in 2.667 HRD-in -74.32, -53.19 77.26, -10.58 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.86, 160.68 APE9-dihe-na 136.11, -166.87 APE8-dihe-in -131.1, 132.63 APE8-rot-in 296.36 APE67-dihe-in -62.36, -23.28 -53.02, -44.84 APE12-dist-in 7.352 APE11-dist-in 10.498 APE10-dist-in 4.91 APE9-dist-in 3.542 K76S,L113V,I118V,I119N,V124I,T128Q,R131K,T148C SEP241 SEP241 XRAY 1.41 0.142 0.174 A 310 284 0 0 0 0 [[82, 342]] 1.0 5mrd Homo sapiens AGC_PDPK1_HUMAN AGC 1.7e-83 285.6 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 3HRFA O15530 75 359 556.0 ATP:1373,P47:1374 ATPlike,Allosteric Active DFGin 6.514 14.784 BLAminus -133.77, -176.11 75.25, 77.12 -110.83, 6.58 287.55, 100.98 -63.85, -22.79 in-in in 8.387 Saltbr-in 2.701 HRD-in -73.67, -53.98 76.59, -10.73 in-in-in SNCiii in-in ActLoopNT-in 2.923 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.42, 166.15 APE9-dihe-na 124.75, -165.6 APE8-dihe-in -127.97, 128.5 APE8-rot-in 295.31 APE67-dihe-in -62.28, -24.12 -44.34, -47.42 APE12-dist-in 7.351 APE11-dist-in 10.546 APE10-dist-in 4.867 APE9-dist-in 3.481 Y288G,Q292A SEP241 SEP241 XRAY 1.9 0.165 0.177 A 311 285 0 0 0 0 [[82, 342]] 1.0 3hrf Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4A06A O15530 75 359 556.0 ATP:500,A06:600 ATPlike,Allosteric Active DFGin 6.512 14.757 BLAminus -135.73, -177.17 74.25, 74.67 -110.25, 11.82 284.97, 101.73 -68.23, -22.46 in-in in 8.319 Saltbr-in 2.864 HRD-in -73.73, -51.84 74.62, -10.07 in-in-in SNCiii in-in ActLoopNT-in 2.92 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.65, 165.25 APE9-dihe-na 128.95, -173.35 APE8-dihe-in -120.15, 131.51 APE8-rot-in 299.31 APE67-dihe-in -59.46, -27.29 -45.75, -47.91 APE12-dist-in 7.336 APE11-dist-in 10.447 APE10-dist-in 4.873 APE9-dist-in 3.509 Y288G,Q292A SEP241 SEP241 XRAY 2.0 0.161 0.198 A 311 285 0 0 0 0 [[82, 342]] 1.0 4a06 Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4AW0A O15530 75 359 556.0 ATP:500,MJF:600 ATPlike,Allosteric Active DFGin 6.531 14.993 BLAminus -134.84, 177.25 78.73, 76.19 -106.3, 8.53 283.51, 97.11 -69.63, -19.36 in-in in 8.595 Saltbr-in 3.009 HRD-in -83.05, -53.03 79.45, -12.94 in-in-in SNCiii in-in ActLoopNT-in 2.934 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.69, 159.04 APE9-dihe-na 139.48, -167.8 APE8-dihe-in -131.87, 132.42 APE8-rot-in 295.45 APE67-dihe-in -61.29, -25.28 -54.74, -42.17 APE12-dist-in 7.509 APE11-dist-in 10.601 APE10-dist-in 5.026 APE9-dist-in 3.58 Y288G,Q292A SEP241 SEP241,CME260 XRAY 1.43 0.171 0.188 A 311 285 0 0 0 0 [[82, 342]] 1.0 4aw0 Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4AW1A O15530 66 359 556.0 ATP:1360,21O:1361 ATPlike,Allosteric Active DFGin 6.325 14.155 BLAminus -137.24, -178.23 68.96, 84.69 -105.37, 17.06 286.01, 86.79 -62.77, -26.7 in-in in 8.576 Saltbr-in 2.864 HRD-in -81.18, -54.06 78.32, -13.29 in-in-in SNCiii in-in ActLoopNT-in 2.849 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.98, 160.2 APE9-dihe-na 130.22, -162.57 APE8-dihe-in -126.98, 128.72 APE8-rot-in 295.96 APE67-dihe-in -57.45, -24.35 -48.01, -47.7 APE12-dist-in 7.653 APE11-dist-in 10.852 APE10-dist-in 5.075 APE9-dist-in 3.586 Y288G,Q292A SEP241 SEP241 XRAY 1.68 0.165 0.186 A 311 287 5 0 0 5 [[82, 342]] 1.0 4aw1 Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4RQKA O15530 74 359 556.0 ATP:403,R1S:404 ATPlike,Allosteric Active DFGin 6.461 14.786 BLAminus -139.06, -177.03 75.27, 72.83 -105.25, 7.36 287.3, 98.33 -64.7, -21.38 in-in in 8.464 Saltbr-in 2.941 HRD-in -73.98, -52.31 74.79, -9.31 in-in-in SNCiii in-in ActLoopNT-in 2.88 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.64, 164.69 APE9-dihe-na 126.87, -171.23 APE8-dihe-in -124.75, 130.48 APE8-rot-in 298.57 APE67-dihe-in -59.79, -23.66 -48.31, -47.88 APE12-dist-in 7.244 APE11-dist-in 10.466 APE10-dist-in 4.918 APE9-dist-in 3.544 Y288G,Q292A SEP241 SEP241 XRAY 1.55 0.133 0.167 A 311 286 0 0 0 0 [[82, 342]] 1.0 4rqk Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4RQVA O15530 71 359 556.0 ATP:405,R2S:406 ATPlike,Allosteric Active DFGin 6.492 14.954 BLAminus -139.41, -174.88 74.87, 69.78 -102.0, 7.85 285.85, 94.73 -65.11, -21.56 in-in in 8.256 Saltbr-in 2.772 HRD-in -72.94, -52.57 74.87, -10.5 in-in-in SNCiii in-in ActLoopNT-in 2.916 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.07, 164.19 APE9-dihe-na 130.69, -171.7 APE8-dihe-in -126.67, 130.74 APE8-rot-in 297.63 APE67-dihe-in -61.47, -23.77 -49.17, -46.26 APE12-dist-in 7.253 APE11-dist-in 10.488 APE10-dist-in 4.969 APE9-dist-in 3.513 Y288G,Q292A SEP241 SEP241 XRAY 1.502 0.133 0.166 A 311 289 0 0 0 0 [[82, 342]] 1.0 4rqv Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 5LVOA O15530 73 359 556.0 ATP:401,78W:402 ATPlike,Allosteric Active DFGin 6.581 15.005 BLAminus -134.78, 179.9 79.12, 70.17 -103.55, 0.25 286.72, 100.66 -64.63, -19.63 in-in in 8.588 Saltbr-in 2.631 HRD-in -71.89, -54.41 77.65, -9.82 in-in-in SNCiii in-in ActLoopNT-in 2.919 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.78, 162.52 APE9-dihe-na 134.75, -167.11 APE8-dihe-in -130.46, 134.12 APE8-rot-in 296.12 APE67-dihe-in -62.26, -22.94 -53.92, -45.37 APE12-dist-in 7.45 APE11-dist-in 10.558 APE10-dist-in 4.984 APE9-dist-in 3.553 Y288G,Q292A SEP241 SEP241 XRAY 1.09 0.136 0.157 A 311 287 0 0 0 0 [[82, 342]] 1.0 5lvo Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4CT1A O15530 76 359 556.0 ATP:500,31S:600 ATPlike,Allosteric None DFGin 6.602 14.979 BLAminus -141.71, -172.51 72.43, 72.08 -107.06, 8.07 284.9, 97.13 -62.67, -20.12 in-none in 8.146 Saltbr-none 999.0 HRD-in -74.62, -54.47 79.43, -8.97 none-in-in SNCnii in-in ActLoopNT-in 2.999 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -143.29, 160.89 APE9-dihe-na 137.85, -171.95 APE8-dihe-in -126.26, 129.35 APE8-rot-in 296.2 APE67-dihe-in -61.08, -24.26 -47.64, -46.5 APE12-dist-in 7.357 APE11-dist-in 10.489 APE10-dist-in 5.018 APE9-dist-in 3.48 L113V,I118V,I119H,V124I,T128Q,R131K,T148C,F157L,Y288G,Q292A SEP241 SEP241 XRAY 1.85 0.172 0.215 A 311 284 0 0 0 0 [[82, 342]] 1.0 4ct1 Homo sapiens AGC_PDPK1_HUMAN AGC 9.5e-84 286.4 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4XX9A O15530 71 359 556.0 ATP:401,RF4:402,RF4:403 ATPlike,Allosteric,Allosteric Active DFGin 6.513 14.988 BLAminus -138.47, -176.21 74.83, 73.76 -104.66, 7.86 282.59, 98.49 -68.99, -20.43 in-in in 8.442 Saltbr-in 2.922 HRD-in -73.71, -50.51 73.32, -9.3 in-in-in SNCiii in-in ActLoopNT-in 2.895 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.41, 162.37 APE9-dihe-na 129.79, -167.49 APE8-dihe-in -129.09, 132.1 APE8-rot-in 295.95 APE67-dihe-in -59.66, -23.23 -49.94, -47.34 APE12-dist-in 7.372 APE11-dist-in 10.575 APE10-dist-in 4.947 APE9-dist-in 3.545 Y288G,Q292A SEP241 SEP241 XRAY 1.4 0.13 0.165 A 310 289 0 0 0 0 [[82, 342]] 1.0 4xx9 Homo sapiens AGC_PDPK1_HUMAN AGC 6.8e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PDPK1 PDPK1_HUMAN 4A07A O15530 75 359 556.0 ATP:500,AZ7:600,AZ7:700 ATPlike,Allosteric,Allosteric Active DFGin 6.655 14.752 BLAminus -135.35, -178.9 76.01, 72.4 -108.94, 8.63 286.31, 98.68 -64.37, -21.88 in-in in 8.621 Saltbr-in 2.919 HRD-in -76.19, -54.82 80.07, -12.14 in-in-in SNCiii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.16, 162.52 APE9-dihe-na 132.15, -164.48 APE8-dihe-in -133.89, 130.56 APE8-rot-in 295.87 APE67-dihe-in -62.13, -24.83 -47.31, -46.9 APE12-dist-in 7.322 APE11-dist-in 10.427 APE10-dist-in 4.998 APE9-dist-in 3.582 Y288G,Q292A SEP241 SEP241,CSS260 XRAY 1.85 0.161 0.2 A 311 285 0 0 0 0 [[82, 342]] 1.0 4a07 Homo sapiens AGC_PDPK1_HUMAN AGC 6.9e-84 286.9 1 260 260 222 223 224 226 228 111 130 134 202 204 203 205 264 252 247 246 245 244 243 242 241 160 3-phosphoinositide-dependent protein kinase 1
AGC PRKACA KAPCA_HUMAN 4WB8A P17612 16 351 351.0 ATP:60401 ATPlike Active DFGin 5.684 14.414 BLAminus -121.45, -177.2 62.67, 77.75 -91.98, 24.58 268.87, 53.09 -58.34, -31.51 in-in in 8.913 Saltbr-in 2.759 HRD-in -95.2, -52.32 70.44, 11.38 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.85, 164.58 APE9-dihe-na 131.46, -156.38 APE8-dihe-in -129.55, 139.43 APE8-rot-in 297.11 APE67-dihe-in -60.54, -22.69 -52.03, -49.04 APE12-dist-in 8.098 APE11-dist-in 11.392 APE10-dist-in 5.827 APE9-dist-in 3.498 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.55 0.164 0.184 A 337 336 0 0 0 0 [[44, 298]] 1.0 4wb8 Homo sapiens AGC_PRKACA_HUMAN AGC 4e-95 323.8 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB5A P17612 14 351 351.0 ATP:60401 ATPlike Active DFGin 5.6 14.452 BLAminus -123.05, 176.84 68.94, 80.02 -91.46, 24.86 270.2, 52.92 -60.74, -31.43 in-in in 9.03 Saltbr-in 2.715 HRD-in -92.12, -52.84 69.8, 13.37 in-in-in SNCiii in-in ActLoopNT-in 2.918 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.48, 163.75 APE9-dihe-na 132.31, -149.49 APE8-dihe-in -132.05, 134.14 APE8-rot-in 301.14 APE67-dihe-in -60.1, -21.12 -48.44, -50.23 APE12-dist-in 8.012 APE11-dist-in 11.4 APE10-dist-in 5.799 APE9-dist-in 3.567 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.641 0.165 0.196 A 350 338 0 0 0 0 [[44, 298]] 1.0 4wb5 Homo sapiens AGC_PRKACA_HUMAN AGC 4.5e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6NO7E P17612 13 351 351.0 ATP:60403 ATPlike Inactive DFGin 6.934 14.165 BLAminus -118.71, 175.9 64.55, 75.01 -86.85, 19.7 273.68, 51.02 -43.49, -41.12 in-out in 9.419 Saltbr-out 5.456 HRD-in -91.66, -53.62 73.72, 11.47 out-in-in SNCoii in-in ActLoopNT-in 3.164 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.9, 150.23 APE9-dihe-na 149.21, -142.3 APE8-dihe-in -132.1, 131.95 APE8-rot-in 297.19 APE67-dihe-in -64.62, -25.64 -37.25, -53.79 APE12-dist-in 8.056 APE11-dist-in 10.984 APE10-dist-in 5.748 APE9-dist-in 3.216 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.55 0.259 0.269 E 350 339 0 0 0 0 [[44, 298]] 1.0 6no7 Homo sapiens AGC_PRKACA_HUMAN AGC 4.5e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6NO7G P17612 15 351 351.0 ATP:60403 ATPlike Inactive DFGin 6.036 14.084 BLAminus -118.68, 176.55 65.34, 76.32 -85.78, 18.75 273.72, 51.07 -44.34, -41.82 in-out in 9.713 Saltbr-out 5.215 HRD-in -91.95, -53.38 74.11, 11.57 out-in-in SNCoii in-in ActLoopNT-in 3.302 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.42, 149.81 APE9-dihe-na 148.91, -142.4 APE8-dihe-in -132.18, 131.68 APE8-rot-in 297.12 APE67-dihe-in -64.98, -25.0 -37.42, -54.32 APE12-dist-in 7.668 APE11-dist-in 10.658 APE10-dist-in 5.553 APE9-dist-in 3.41 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.55 0.259 0.269 G 350 337 0 0 0 0 [[44, 298]] 1.0 6no7 Homo sapiens AGC_PRKACA_HUMAN AGC 4.5e-95 323.7 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB7A P17612 2 351 351.0 ATP:60501 ATPlike Active DFGin 5.445 14.649 BLAminus -119.06, -174.39 59.4, 77.28 -89.09, 26.42 267.74, 51.48 -60.48, -28.34 in-in in 8.87 Saltbr-in 2.769 HRD-in -93.55, -50.9 68.82, 8.95 in-in-in SNCiii in-in ActLoopNT-in 2.942 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.63, 158.06 APE9-dihe-na 139.02, -156.91 APE8-dihe-in -126.94, 137.23 APE8-rot-in 299.54 APE67-dihe-in -64.26, -23.0 -50.4, -48.13 APE12-dist-in 8.18 APE11-dist-in 11.54 APE10-dist-in 5.955 APE9-dist-in 3.723 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.9 0.152 0.188 A 405 336 0 0 0 0 [[44, 298]] 1.0 4wb7 Homo sapiens AGC_PRKACA_HUMAN AGC 7e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB7B P17612 2 351 351.0 ATP:60501 ATPlike Active DFGin 5.38 14.712 BLAminus -115.93, -176.79 62.38, 75.33 -88.91, 25.18 264.71, 51.71 -56.9, -30.26 in-in in 8.962 Saltbr-in 2.773 HRD-in -94.01, -50.55 67.24, 10.48 in-in-in SNCiii in-in ActLoopNT-in 2.939 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.07, 161.39 APE9-dihe-na 132.31, -156.17 APE8-dihe-in -127.2, 138.18 APE8-rot-in 298.14 APE67-dihe-in -59.62, -23.37 -52.63, -48.78 APE12-dist-in 8.198 APE11-dist-in 11.563 APE10-dist-in 5.97 APE9-dist-in 3.642 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.9 0.152 0.188 B 405 336 0 0 0 0 [[44, 298]] 1.0 4wb7 Homo sapiens AGC_PRKACA_HUMAN AGC 7e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6BYRA P17612 2 351 351.0 ATP:60501 ATPlike Active DFGin 5.626 14.616 BLAminus -128.29, 177.03 62.06, 86.64 -97.54, 28.59 271.87, 66.62 -63.2, -33.23 in-in in 8.808 Saltbr-in 3.196 HRD-in -87.43, -52.47 67.28, 5.18 in-in-in SNCiii in-in ActLoopNT-in 3.193 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.51, 153.24 APE9-dihe-na 149.32, -133.8 APE8-dihe-in -139.35, 133.91 APE8-rot-in 312.31 APE67-dihe-in -68.4, -6.95 -52.73, -48.25 APE12-dist-in 8.734 APE11-dist-in 11.076 APE10-dist-in 5.63 APE9-dist-in 3.491 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.661 0.203 0.249 A 405 336 0 0 0 0 [[44, 298]] 1.0 6byr Homo sapiens AGC_PRKACA_HUMAN AGC 7e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 6BYRC P17612 2 351 351.0 ATP:60501 ATPlike Active DFGin 5.679 14.34 BLAminus -129.89, 172.29 61.76, 74.25 -79.2, 34.93 281.69, 54.14 -61.8, -27.34 in-in in 8.733 Saltbr-in 2.498 HRD-in -93.13, -49.8 64.55, 7.44 in-in-in SNCiii in-in ActLoopNT-in 3.052 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.29, 161.94 APE9-dihe-na 130.51, -156.26 APE8-dihe-in -112.31, 134.09 APE8-rot-in 302.07 APE67-dihe-in -64.15, -16.52 -52.64, -41.39 APE12-dist-in 8.316 APE11-dist-in 11.106 APE10-dist-in 5.767 APE9-dist-in 3.618 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 3.661 0.203 0.249 C 405 336 0 0 0 0 [[44, 298]] 1.0 6byr Homo sapiens AGC_PRKACA_HUMAN AGC 7e-95 323.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 9EDCA P17612 14 351 351.0 ATP:60400 ATPlike Active DFGin 5.626 13.772 BLAminus -125.61, -173.52 60.53, 69.6 -81.59, 16.86 273.36, 51.23 -62.38, -30.28 in-in in 9.129 Saltbr-in 3.0 HRD-in -112.54, -46.7 65.17, 1.82 in-in-in SNCiii in-in ActLoopNT-in 3.14 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -158.87, 159.92 APE9-dihe-na 136.42, -156.18 APE8-dihe-in -101.13, 126.83 APE8-rot-in 299.98 APE67-dihe-in -84.76, -8.6 -60.74, -28.35 APE12-dist-in 7.999 APE11-dist-in 11.111 APE10-dist-in 5.797 APE9-dist-in 3.748 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 EM 4.18 999.0 999.0 A 350 338 0 0 0 0 [[44, 298]] 1.0 9edc Homo sapiens AGC_PRKACA_HUMAN AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 9EDDA P17612 14 351 351.0 ATP:60400 ATPlike Inactive DFGin 7.642 15.48 BLAminus -131.38, -176.44 56.47, 73.0 -86.17, 32.62 269.53, 53.11 -62.17, -29.29 in-out in 9.617 Saltbr-out 3.947 HRD-in -100.83, -51.39 64.03, -2.2 out-out-out SNCooo out-out ActLoopNT-out 3.703 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -126.87, 141.16 APE9-dihe-na 150.41, -172.01 APE8-dihe-in -103.27, 147.74 APE8-rot-out 185.24 APE67-dihe-in -92.0, 3.92 -57.96, -27.57 APE12-dist-in 8.165 APE11-dist-in 11.275 APE10-dist-in 5.628 APE9-dist-in 4.227 None TPO198,SEP339 TPO198,SEP339 EM 6.3 999.0 999.0 A 350 338 0 0 0 0 [[44, 298]] 1.0 9edd Homo sapiens AGC_PRKACA_HUMAN AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 9EDEA P17612 14 351 351.0 ATP:60400 ATPlike Inactive DFGin 6.692 15.188 BLAminus -131.57, -176.8 59.06, 65.59 -87.14, 28.49 267.05, 50.71 -66.29, -36.64 in-out in 9.922 Saltbr-out 4.682 HRD-in -115.21, -49.18 64.38, 4.15 out-out-out SNCooo out-out ActLoopNT-out 3.632 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -122.67, 141.1 APE9-dihe-na 158.89, -177.66 APE8-dihe-in -75.58, 154.98 APE8-rot-out 190.35 APE67-dihe-in -109.16, -25.21 -65.33, -8.36 APE12-dist-in 8.347 APE11-dist-in 11.783 APE10-dist-in 6.829 APE9-dist-in 4.918 None TPO198,SEP339 TPO198,SEP339 EM 5.9 999.0 999.0 A 350 338 0 0 0 0 [[44, 298]] 1.0 9ede Homo sapiens AGC_PRKACA_HUMAN AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB6A P17612 14 351 351.0 ATP:60401 ATPlike Active DFGin 6.068 14.398 BLAminus -118.38, -169.49 51.77, 82.47 -95.61, 17.78 271.18, 55.73 -42.8, -37.29 in-in in 8.83 Saltbr-in 2.561 HRD-in -94.17, -52.18 74.17, 2.46 in-in-in SNCiii in-in ActLoopNT-in 2.948 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.55, 166.68 APE9-dihe-na 116.18, 128.45 APE8-dihe-in -46.62, 128.74 APE8-rot-in 303.5 APE67-dihe-in -58.01, -23.74 -49.09, -50.89 APE12-dist-in 8.046 APE11-dist-in 11.764 APE10-dist-in 6.243 APE9-dist-in 3.767 L206R SEP11,SEP140,TPO198 SEP11,SEP140,TPO198 XRAY 2.1 0.19 0.237 A 350 338 0 0 0 0 [[44, 298]] 1.0 4wb6 Homo sapiens AGC_PRKACA_HUMAN AGC 8.6e-94 319.5 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_HUMAN 4WB6B P17612 9 351 351.0 ATP:60401 ATPlike Active DFGin 5.872 14.073 BLAminus -117.82, -168.32 53.27, 78.35 -91.25, 29.34 274.97, 62.46 -60.26, -35.85 in-in in 8.687 Saltbr-in 2.75 HRD-in -101.62, -46.5 64.42, 3.48 in-in-in SNCiii in-in ActLoopNT-in 2.946 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.38, 164.15 APE9-dihe-na 120.83, 133.18 APE8-dihe-in -48.66, 125.41 APE8-rot-in 298.86 APE67-dihe-in -54.58, -37.6 -53.55, -42.52 APE12-dist-in 8.078 APE11-dist-in 11.617 APE10-dist-in 6.204 APE9-dist-in 3.822 L206R SEP11,TPO198,SEP339 SEP11,TPO198,SEP339 XRAY 2.1 0.19 0.237 B 350 343 0 0 0 0 [[44, 298]] 1.0 4wb6 Homo sapiens AGC_PRKACA_HUMAN AGC 8.6e-94 319.5 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKCI KPCI_HUMAN 3A8WA P41743 249 588 596.0 ATP:60601 ATPlike Inactive DFGin 5.174 12.378 BLAminus -132.69, 170.49 67.34, 88.86 -96.11, 11.96 304.5, 130.94 -60.46, -20.34 in-out in 8.357 Saltbr-out 3.882 HRD-in -61.87, -57.79 75.89, -1.36 out-in-in SNCoii in-in ActLoopNT-in 2.771 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -163.32, 177.7 APE9-dihe-na 120.34, -178.18 APE8-dihe-in -99.49, 131.04 APE8-rot-in 301.47 APE67-dihe-in -55.52, -25.65 -39.88, -56.62 APE12-dist-in 8.769 APE11-dist-in 11.767 APE10-dist-in 6.259 APE9-dist-in 3.666 None TPO412,TPO564 TPO412,TPO564 XRAY 2.1 0.25 0.301 A 345 325 15 0 0 0 [[254, 522]] 1.0 3a8w Homo sapiens AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKCI KPCI_HUMAN 3A8WB P41743 249 588 596.0 ATP:60601 ATPlike Inactive DFGin 5.257 12.324 BLAminus -133.61, 172.63 64.84, 89.8 -97.52, 11.0 299.58, 138.75 -72.95, 35.24 in-out in 8.192 Saltbr-out 3.977 HRD-in -61.03, -56.18 70.75, 8.33 out-in-in SNCoii in-in ActLoopNT-in 2.997 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -171.82, 179.6 APE9-dihe-na 132.39, -163.28 APE8-dihe-in -113.8, 132.71 APE8-rot-in 303.74 APE67-dihe-in -61.94, -22.49 -35.42, -58.51 APE12-dist-in 8.76 APE11-dist-in 11.726 APE10-dist-in 6.539 APE9-dist-in 3.77 None TPO412,TPO564 TPO412,TPO564 XRAY 2.1 0.25 0.301 B 345 326 14 0 0 3 [[254, 522]] 1.0 3a8w Homo sapiens AGC_PRKCI_HUMAN AGC 1.1e-95 325.6 1 260 260 395 396 397 399 401 283 302 306 375 377 376 378 435 423 418 417 416 415 414 413 412 333 Protein kinase C iota type
AGC PRKG1 KGP1_HUMAN 7T4TA Q13976 204 671 671.0 PCG:60701,ATP:60702 Allosteric,ATPlike Inactive DFGin 5.806 14.933 ABAminus -123.17, -29.2 -107.96, 118.17 -112.33, 30.1 285.53, 74.3 -67.24, -29.77 in-in in 9.557 Saltbr-in 3.38 HRD-in -86.67, -51.63 61.2, 10.68 in-in-in SNCiii in-in ActLoopNT-in 2.86 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -166.89, 164.61 APE9-dihe-na 124.7, -170.63 APE8-dihe-in -100.54, 134.31 APE8-rot-in 302.38 APE67-dihe-in -67.0, -27.98 -44.1, -43.89 APE12-dist-in 7.941 APE11-dist-in 10.713 APE10-dist-in 5.308 APE9-dist-in 3.712 None TPO517 TPO517 XRAY 2.08 0.19 0.221 A 469 453 0 0 0 0 [[360, 619]] 1.0 7t4t Homo sapiens AGC_PRKG1_HUMAN AGC 6.4e-84 287.2 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
AGC PRKG1 KGP1_HUMAN 7T4TB Q13976 204 671 671.0 PCG:60701,ATP:60702 Allosteric,ATPlike Inactive DFGin 5.8 14.811 ABAminus -121.38, -38.76 -100.76, 117.73 -112.4, 30.34 285.48, 73.71 -68.75, -29.12 in-in in 9.401 Saltbr-in 3.311 HRD-in -86.82, -51.68 61.52, 10.16 in-in-in SNCiii in-in ActLoopNT-in 2.853 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -165.5, 164.27 APE9-dihe-na 124.32, -169.95 APE8-dihe-in -101.18, 134.26 APE8-rot-in 302.8 APE67-dihe-in -67.54, -26.94 -44.3, -44.01 APE12-dist-in 7.957 APE11-dist-in 10.757 APE10-dist-in 5.336 APE9-dist-in 3.717 None TPO517 TPO517 XRAY 2.08 0.19 0.221 B 469 453 0 0 0 0 [[360, 619]] 1.0 7t4t Homo sapiens AGC_PRKG1_HUMAN AGC 6.4e-84 287.2 1 260 260 501 502 503 505 507 390 409 413 481 483 482 484 540 528 523 522 521 520 519 518 517 439 cGMP-dependent protein kinase 1
CAMK AURKA AURKA_HUMAN 5DNRA O14965 126 390 403.0 ATP:403 ATPlike Inactive DFGin 5.655 15.024 BLAminus -132.27, -179.72 60.78, 76.64 -90.12, 18.66 275.93, 74.44 -56.64, -35.89 in-in in 9.166 Saltbr-in 2.747 HRD-in -79.07, -53.73 71.53, 2.24 in-in-out SNCiio in-out ActLoopNT-in 2.945 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -125.56, 5.88 APE9-dihe-na -79.83, -178.97 APE8-dihe-in -49.83, 123.63 APE8-rot-in 300.84 APE67-dihe-in -48.83, -30.32 -94.71, -13.22 APE12-dist-in 9.348 APE11-dist-in 13.115 APE10-dist-out 15.947 APE9-dist-out 11.204 None TPO288 TPO288 XRAY 1.95 0.206 0.226 A 272 265 0 0 0 0 [[133, 383]] 1.0 5dnr Homo sapiens CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DT3A O14965 127 390 403.0 ATP:403 ATPlike Inactive DFGin 5.731 15.047 BLAminus -138.47, 178.42 59.62, 78.35 -90.84, 24.83 281.41, 74.26 -61.06, -31.68 in-in in 9.451 Saltbr-in 2.917 HRD-in -69.42, -55.99 70.31, -3.53 in-in-out SNCiio in-out ActLoopNT-in 2.892 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -112.53, -5.85 APE9-dihe-na -110.59, -164.26 APE8-dihe-in -61.03, 149.68 APE8-rot-out 193.86 APE67-dihe-in -45.37, -39.19 -93.82, -1.33 APE12-dist-in 12.181 APE11-dist-in 10.015 APE10-dist-out 11.694 APE9-dist-out 10.487 None TPO287 TPO287 XRAY 2.33 0.21 0.243 A 273 264 0 0 0 0 [[133, 383]] 1.0 5dt3 Homo sapiens CAMK_AURKA_HUMAN CAMK 6.5e-80 274.1 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DRDA O14965 127 390 403.0 ATP:402 ATPlike Inactive DFGin 6.179 15.49 BLAminus -124.75, -173.07 54.37, 73.03 -91.89, 14.82 276.39, 76.92 -60.47, -27.86 in-in in 9.094 Saltbr-in 2.712 HRD-in -86.49, -50.72 75.89, 5.8 in-in-out SNCiio in-out ActLoopNT-in 3.009 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -110.08 APE9-dihe-na -77.61, -136.85 APE8-dihe-in -63.84, 145.87 APE8-rot-out 199.39 APE67-dihe-in -52.56, -31.45 -96.52, -6.4 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.847 APE9-dist-out 10.623 T287A None None XRAY 2.13 0.209 0.262 A 273 259 5 0 0 5 [[133, 383]] 1.0 5drd Homo sapiens CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 1OL6A O14965 128 388 403.0 ATP:1388 ATPlike Inactive DFGin 5.851 15.64 BLAminus -135.92, 178.5 52.45, 77.03 -92.23, 24.52 292.21, 75.73 -61.17, -14.48 in-out in 9.912 Saltbr-out 4.669 HRD-in -62.99, -55.9 71.29, 3.18 out-in-none SNCoin in-none ActLoopNT-in 3.099 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 131.06 APE8-rot-in 336.17 APE67-dihe-in -65.51, -21.75 -47.85, -55.32 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 D274N None None XRAY 3.0 0.277 0.301 A 282 246 15 0 0 11 [[133, 383]] 1.0 1ol6 Homo sapiens CAMK_AURKA_HUMAN CAMK 4.4e-79 271.4 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DN3A O14965 125 389 403.0 5DN:402,ATP:404 Allosteric,ATPlike Inactive DFGin 5.699 15.042 BLAminus -130.89, -174.42 55.28, 74.81 -88.98, 14.12 275.51, 75.93 -51.92, -35.15 in-in in 9.166 Saltbr-in 2.72 HRD-in -77.57, -53.05 71.13, 1.06 in-in-out SNCiio in-out ActLoopNT-in 2.956 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -118.61, -13.13 APE9-dihe-na -74.86, -176.69 APE8-dihe-in -54.45, 125.21 APE8-rot-in 310.73 APE67-dihe-in -44.24, -34.14 -96.33, -16.24 APE12-dist-in 9.435 APE11-dist-in 13.235 APE10-dist-out 15.667 APE9-dist-out 11.232 None TPO288 TPO288 XRAY 2.05 0.192 0.203 A 272 265 0 0 0 0 [[133, 383]] 1.0 5dn3 Homo sapiens CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 8C1EA O14965 127 388 403.0 T0X:401,ATP:403 Allosteric,ATPlike Inactive DFGin 5.798 14.807 BLAminus -150.0, 179.01 57.43, 76.53 -96.95, 20.99 278.49, 67.97 -56.09, -34.21 in-in in 9.191 Saltbr-in 2.847 HRD-in -74.81, -56.51 74.42, -5.07 in-in-out SNCiio in-out ActLoopNT-in 2.615 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -165.45, 99.75 APE9-dihe-na -118.34, -95.63 APE8-dihe-in -111.54, 127.78 APE8-rot-in 354.95 APE67-dihe-in -38.77, -37.51 -96.45, -21.24 APE12-dist-in 9.259 APE11-dist-in 13.544 APE10-dist-out 15.259 APE9-dist-out 10.896 None TPO288 TPO288 XRAY 2.798 0.176 0.239 A 272 262 0 0 0 0 [[133, 383]] 1.0 8c1e Homo sapiens CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DT4A O14965 127 390 403.0 5DN:402,ATP:403 Allosteric,ATPlike Inactive DFGin 6.023 15.016 BLAminus -131.6, -179.1 56.58, 87.02 -103.91, 25.71 282.11, 78.42 -59.32, -42.3 in-in in 9.544 Saltbr-in 3.004 HRD-in -66.18, -52.21 66.74, -14.36 in-in-out SNCiio in-out ActLoopNT-in 2.944 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -57.69 APE9-dihe-na -89.02, -152.47 APE8-dihe-in -67.56, 141.58 APE8-rot-out 191.42 APE67-dihe-in -59.88, -41.29 -85.27, 2.2 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.159 APE9-dist-out 9.973 None None None XRAY 2.86 0.193 0.256 A 273 259 5 0 0 5 [[133, 383]] 1.0 5dt4 Homo sapiens CAMK_AURKA_HUMAN CAMK 6.5e-80 274.1 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DOSA O14965 127 390 403.0 5DN:402,ATP:403 Allosteric,ATPlike Inactive DFGin 5.9 15.044 BLAminus -141.11, -178.41 56.44, 85.64 -101.51, 29.55 282.61, 75.97 -61.45, -42.65 in-in in 9.493 Saltbr-in 2.861 HRD-in -75.29, -42.25 59.65, -8.83 in-in-out SNCiio in-out ActLoopNT-in 3.042 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, -79.83 APE9-dihe-na -91.08, -144.18 APE8-dihe-in -65.26, 123.97 APE8-rot-out 190.75 APE67-dihe-in -25.49, -64.25 -63.86, -31.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.033 APE9-dist-out 9.793 T287A None None XRAY 2.98 0.201 0.273 A 273 259 5 0 0 5 [[133, 383]] 1.0 5dos Homo sapiens CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5DR2A O14965 128 390 403.0 5E1:60401,ATP:60403 Allosteric,ATPlike Inactive DFGin 5.742 15.148 BLAminus -112.74, -178.24 59.1, 85.93 -103.74, 31.08 282.48, 80.94 -64.76, -39.96 in-in in 9.225 Saltbr-in 2.845 HRD-in -83.01, -54.44 78.2, -2.4 in-in-out SNCiio in-out ActLoopNT-in 2.871 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iioo APE10-dihe-na -117.43, 59.62 APE9-dihe-na -131.57, -163.05 APE8-dihe-in -74.95, 143.42 APE8-rot-out 161.96 APE67-dihe-in -60.88, -32.64 -91.05, 11.96 APE12-dist-in 12.526 APE11-dist-in 9.121 APE10-dist-out 12.632 APE9-dist-out 10.039 T287A None None XRAY 2.46 0.225 0.285 A 273 263 0 0 0 0 [[133, 383]] 1.0 5dr2 Homo sapiens CAMK_AURKA_HUMAN CAMK 1e-79 273.4 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK AURKA AURKA_HUMAN 5OBJA O14965 127 390 403.0 ATP:404,9QK:405 ATPlike,Allosteric Inactive DFGin 6.016 15.967 None -127.31, -156.34 57.9, -96.92 69.6, 25.6 277.68, 99.91 -74.82, -34.09 out-out out 10.869 Saltbr-out 3.975 HRD-in -84.35, -43.15 67.43, 1.86 out-in-out SNCoio in-out ActLoopNT-in 2.747 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, -85.06 APE9-dihe-na -106.73, -153.17 APE8-dihe-in -86.88, 144.13 APE8-rot-in 279.73 APE67-dihe-in -52.07, -35.29 -66.02, -11.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 9.379 APE9-dist-out 10.199 None None None XRAY 2.901 0.215 0.245 A 272 260 4 0 0 4 [[133, 383]] 1.0 5obj Homo sapiens CAMK_AURKA_HUMAN CAMK 6.4e-80 274.1 1 256 256 273 274 275 277 279 162 181 185 253 255 254 256 311 299 294 293 292 291 290 289 288 211 Aurora kinase A
CAMK CAMK1 KCC1A_HUMAN 4FG7A Q14012 9 277 370.0 ATP:301 ATPlike None DFGin 6.733 14.558 BLAminus -139.66, 179.97 56.25, 83.23 -95.06, 23.76 286.93, 75.78 -57.64, -10.34 in-in in 9.756 Saltbr-in 2.988 HRD-in -66.62, -51.56 76.61, -3.11 in-in-none SNCiin in-none ActLoopNT-in 2.968 ActLoopCT-none nonTYR APEdihe_aaiii APEdist_nnni APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 148.43 APE8-dihe-in -71.0, 118.39 APE8-rot-in 317.82 APE67-dihe-inflip 114.74, -42.57 -57.89, 141.16 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-in 5.149 None None None XRAY 2.7 0.221 0.246 A 293 250 19 0 0 8 [[20, 276]] 1.0 4fg7 Homo sapiens CAMK_CAMK1_HUMAN CAMK 6.7e-97 329.7 1 256 256 161 162 163 165 167 49 66 70 138 140 139 141 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1 KCC1A_HUMAN 4FG9A Q14012 10 314 370.0 ATP:401 ATPlike Inactive DFGinter 6.372 9.923 None -94.72, -48.11 -72.17, 151.42 -111.14, 999.0 291.22, 108.3 999.0, 999.0 out-out out 13.251 Saltbr-out 11.213 HRD-in -52.69, -68.08 75.14, -19.91 out-none-none SNConn none-none ActLoopNT-none 999.0 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 133.2, -24.01 999.0, 22.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.4 0.211 0.249 A 320 278 27 0 0 18 [[20, 276]] 1.0 4fg9 Homo sapiens CAMK_CAMK1_HUMAN CAMK 9.2e-97 329.5 1 256 256 161 162 163 165 167 49 66 70 138 140 139 141 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1 KCC1A_HUMAN 4FG9B Q14012 14 314 370.0 ATP:401 ATPlike Inactive DFGinter 6.287 9.324 None -97.62, -42.8 -76.25, 145.4 -105.57, 999.0 303.86, 102.8 999.0, 999.0 out-none out 16.899 Saltbr-none 999.0 HRD-in -42.26, -58.83 67.77, -17.08 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaini APEdist_nnno APE10-dihe-na -80.77, -34.84 APE9-dihe-na -79.39, -52.09 APE8-dihe-in -108.11, 99.06 APE8-rot-none 999.0 APE67-dihe-inflip 97.92, -38.15 -85.42, 136.58 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.53 None None None XRAY 2.4 0.211 0.249 B 320 279 22 0 0 10 [[20, 276]] 1.0 4fg9 Homo sapiens CAMK_CAMK1_HUMAN CAMK 9.2e-97 329.5 1 256 256 161 162 163 165 167 49 66 70 138 140 139 141 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1 KCC1A_HUMAN 4FG8A Q14012 10 299 370.0 ATP:401 ATPlike Inactive None 999.0 999.0 None -88.48, -49.15 -70.71, 166.62 -106.58, 999.0 999.0, 999.0 999.0, 999.0 out-none out 14.285 Saltbr-none 999.0 HRD-in -68.76, -57.94 73.69, -12.61 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aanno APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -41.56 APE8-rot-none 999.0 APE67-dihe-out 113.32, -70.06 -37.24, 130.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.2 0.198 0.248 A 315 263 27 0 0 17 [[20, 276]] 1.0 4fg8 Homo sapiens CAMK_CAMK1_HUMAN CAMK 8.7e-97 329.4 1 256 256 161 162 163 165 167 49 66 70 138 140 139 141 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK1 KCC1A_HUMAN 4FG8B Q14012 14 299 370.0 ATP:401 ATPlike Inactive None 999.0 999.0 None -101.4, -28.72 -75.18, 152.13 -127.71, -74.73 999.0, 999.0 -143.25, 999.0 out-none out 14.497 Saltbr-none 999.0 HRD-in -60.93, -60.01 82.66, -21.6 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaino APEdist_nnno APE10-dihe-na -81.34, -37.41 APE9-dihe-na -69.8, -52.82 APE8-dihe-in -110.8, 85.13 APE8-rot-none 999.0 APE67-dihe-out 122.52, -61.56 -92.65, 135.96 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 11.952 None None None XRAY 2.2 0.198 0.248 B 315 268 18 0 0 7 [[20, 276]] 1.0 4fg8 Homo sapiens CAMK_CAMK1_HUMAN CAMK 8.7e-97 329.4 1 256 256 161 162 163 165 167 49 66 70 138 140 139 141 200 188 183 182 181 180 179 178 177 96 Calcium/calmodulin-dependent protein kinase type 1
CAMK CAMK2A KCC2A_HUMAN 7UIRA Q9UQM7 7 274 478.0 ATP:302 ATPlike Active DFGin 6.045 15.107 BLAminus -137.0, 179.68 44.28, 101.28 -106.42, 24.78 295.79, 81.95 -53.14, -27.06 in-in in 9.85 Saltbr-in 3.466 HRD-in -74.22, -43.69 67.52, 3.92 in-in-in SNCiii in-in ActLoopNT-in 2.909 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.48, 156.41 APE9-dihe-na 131.95, -156.1 APE8-dihe-in -122.09, 129.91 APE8-rot-in 298.28 APE67-dihe-in -55.12, -36.11 -51.43, -40.3 APE12-dist-in 10.333 APE11-dist-in 11.793 APE10-dist-in 6.056 APE9-dist-in 3.425 D135N,Q223K None None XRAY 3.1 0.234 0.274 A 268 268 0 0 0 0 [[13, 271]] 1.0 7uir Homo sapiens CAMK_CAMK2A_HUMAN CAMK 9.3e-96 326.0 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 7UIRB Q9UQM7 7 273 478.0 ATP:301 ATPlike Active DFGin 6.093 14.463 BLAminus -136.84, -179.4 43.86, 99.82 -105.8, 24.57 296.99, 81.24 -56.04, -26.17 in-in in 9.403 Saltbr-in 3.027 HRD-in -74.93, -42.65 67.84, 3.24 in-in-in SNCiii in-in ActLoopNT-in 2.915 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -148.86, 157.92 APE9-dihe-na 132.59, -155.55 APE8-dihe-in -122.09, 129.05 APE8-rot-in 298.73 APE67-dihe-in -54.7, -35.97 -51.63, -40.47 APE12-dist-in 10.303 APE11-dist-in 11.733 APE10-dist-in 5.989 APE9-dist-in 3.504 D135N,Q223K None None XRAY 3.1 0.234 0.274 B 268 261 6 0 0 0 [[13, 271]] 1.0 7uir Homo sapiens CAMK_CAMK2A_HUMAN CAMK 9.3e-96 326.0 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 7UJPB Q9UQM7 7 273 478.0 ATP:301 ATPlike Active DFGin 6.942 14.313 BLAminus -133.64, 174.92 62.39, 75.15 -97.38, 27.07 283.14, 81.65 -64.42, -25.12 in-in in 8.558 Saltbr-in 2.783 HRD-in -76.01, -51.46 77.74, -9.31 in-in-in SNCiii in-in ActLoopNT-in 2.871 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.94, 139.06 APE9-dihe-na 146.74, -166.31 APE8-dihe-in -115.05, 124.1 APE8-rot-in 308.42 APE67-dihe-in -69.31, -14.12 -35.51, -54.36 APE12-dist-in 10.25 APE11-dist-in 11.592 APE10-dist-in 5.843 APE9-dist-in 3.572 D135N,Q223K None None XRAY 2.56 0.234 0.281 B 268 267 0 0 0 0 [[13, 271]] 1.0 7ujp Homo sapiens CAMK_CAMK2A_HUMAN CAMK 9.3e-96 326.0 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK CAMK2A KCC2A_HUMAN 7UJTA Q9UQM7 7 274 478.0 ATP:301 ATPlike Inactive DFGin 5.793 15.871 BLAminus -136.06, 173.98 63.2, 83.03 -96.5, 26.66 288.93, 81.42 -61.86, -26.9 out-out out 10.354 Saltbr-out 4.962 HRD-in -68.86, -51.05 77.4, -6.28 out-in-in SNCoii in-in ActLoopNT-in 2.865 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -146.17, 142.76 APE9-dihe-na 138.67, -159.02 APE8-dihe-in -111.71, 119.97 APE8-rot-in 304.14 APE67-dihe-in -65.52, -19.91 -39.43, -49.22 APE12-dist-in 10.406 APE11-dist-in 11.791 APE10-dist-in 5.962 APE9-dist-in 3.835 D135N,Q223K None None XRAY 2.1 0.205 0.246 A 268 268 0 0 0 0 [[13, 271]] 1.0 7ujt Homo sapiens CAMK_CAMK2A_HUMAN CAMK 9.3e-96 326.0 1 256 256 155 156 157 159 161 42 60 64 132 134 133 135 195 183 178 177 176 175 174 173 172 90 Calcium/calmodulin-dependent protein kinase type II subunit alpha
CAMK PHKG1 PHKG1_HUMAN 8Z5RC Q16816 12 383 387.0 ATP:401 ATPlike Inactive DFGin 6.216 15.79 BLAminus -134.62, -175.38 59.67, 63.56 -84.41, -0.54 270.17, 147.24 -63.63, -41.24 out-none out 10.415 Saltbr-none 999.0 HRD-in -97.74, -41.95 55.77, 14.53 none-out-in SNCnoi out-in ActLoopNT-out 3.722 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.82, 162.86 APE9-dihe-na 112.58, 179.42 APE8-dihe-in -65.24, 137.27 APE8-rot-in 278.19 APE67-dihe-in -93.32, 13.97 -60.86, -18.95 APE12-dist-in 9.617 APE11-dist-in 12.162 APE10-dist-in 7.279 APE9-dist-in 5.452 None None None EM 3.52 999.0 999.0 C 387 372 0 0 0 0 [[20, 288]] 1.0 8z5r Homo sapiens CAMK_PHKG1_HUMAN CAMK 1.4e-85 292.7 1 256 256 167 168 169 171 173 49 74 78 147 149 148 150 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK PHKG1 PHKG1_HUMAN 8Z5TC Q16816 12 383 387.0 ATP:401 ATPlike Inactive DFGin 5.966 13.989 BLAminus -135.48, -169.66 58.09, 63.88 -81.9, 2.43 303.6, 100.06 -62.94, -40.27 out-none out 10.687 Saltbr-none 999.0 HRD-in -92.65, -46.31 62.21, 13.41 none-out-in SNCnoi out-in ActLoopNT-out 3.786 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.91, 163.41 APE9-dihe-na 112.45, -178.89 APE8-dihe-in -64.37, 134.79 APE8-rot-in 304.3 APE67-dihe-in -88.43, 6.38 -60.59, -20.91 APE12-dist-in 9.348 APE11-dist-in 12.089 APE10-dist-in 7.211 APE9-dist-in 5.344 None None None EM 3.74 999.0 999.0 C 387 372 0 0 0 0 [[20, 288]] 1.0 8z5t Homo sapiens CAMK_PHKG1_HUMAN CAMK 1.4e-85 292.7 1 256 256 167 168 169 171 173 49 74 78 147 149 148 150 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK PHKG1 PHKG1_HUMAN 8Z5TG Q16816 12 383 387.0 ATP:401 ATPlike Inactive DFGin 6.211 16.35 BLAminus -138.41, -165.95 59.18, 62.46 -88.91, 3.24 271.18, 147.97 -59.75, -36.25 out-none out 10.64 Saltbr-none 999.0 HRD-in -91.86, -44.41 50.14, 19.86 none-out-out SNCnoo out-out ActLoopNT-out 3.788 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -170.81, -171.47 APE9-dihe-na 86.12, 176.52 APE8-dihe-in -63.45, 134.1 APE8-rot-in 318.38 APE67-dihe-in -94.57, 4.67 -60.84, -20.41 APE12-dist-in 10.099 APE11-dist-out 14.019 APE10-dist-out 9.046 APE9-dist-in 5.833 None None None EM 3.74 999.0 999.0 G 387 372 0 0 0 0 [[20, 288]] 1.0 8z5t Homo sapiens CAMK_PHKG1_HUMAN CAMK 1.4e-85 292.7 1 256 256 167 168 169 171 173 49 74 78 147 149 148 150 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK PHKG1 PHKG1_HUMAN 8Z5TK Q16816 12 383 387.0 ATP:401 ATPlike Inactive DFGin 6.819 16.43 BLAminus -134.15, -169.32 57.8, 62.87 -86.64, 0.65 265.34, 130.05 -62.73, -39.71 out-none out 10.331 Saltbr-none 999.0 HRD-in -97.03, -55.84 67.06, 16.56 none-out-in SNCnoi out-in ActLoopNT-out 3.805 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.95, 163.43 APE9-dihe-na 106.51, -175.76 APE8-dihe-in -64.59, 130.37 APE8-rot-in 311.03 APE67-dihe-in -88.59, 5.57 -61.92, -16.15 APE12-dist-in 9.554 APE11-dist-in 12.273 APE10-dist-in 7.366 APE9-dist-in 5.268 None None None EM 3.74 999.0 999.0 K 387 372 0 0 0 0 [[20, 288]] 1.0 8z5t Homo sapiens CAMK_PHKG1_HUMAN CAMK 1.4e-85 292.7 1 256 256 167 168 169 171 173 49 74 78 147 149 148 150 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK PHKG1 PHKG1_HUMAN 8Z5TO Q16816 12 383 387.0 ATP:401 ATPlike Inactive DFGin 6.326 15.79 BLAminus -126.17, -170.44 58.71, 63.18 -85.3, 0.59 276.38, 60.06 -63.17, -41.01 out-none out 10.539 Saltbr-none 999.0 HRD-in -82.25, -48.84 62.3, 10.36 none-out-in SNCnoi out-in ActLoopNT-out 3.696 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -159.09, 163.04 APE9-dihe-na 110.51, -176.12 APE8-dihe-in -65.19, 138.82 APE8-rot-in 315.28 APE67-dihe-in -94.37, 8.66 -62.65, -15.41 APE12-dist-in 9.558 APE11-dist-in 12.086 APE10-dist-in 7.195 APE9-dist-in 5.52 None None None EM 3.74 999.0 999.0 O 387 372 0 0 0 0 [[20, 288]] 1.0 8z5t Homo sapiens CAMK_PHKG1_HUMAN CAMK 1.4e-85 292.7 1 256 256 167 168 169 171 173 49 74 78 147 149 148 150 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK STK17B ST17B_HUMAN 7Q7DA O94768 25 297 372.0 ATP:60401 ATPlike Inactive DFGin 5.979 13.981 BLAminus -131.01, 179.34 62.41, 83.11 -104.07, 20.6 289.75, 84.41 -62.74, -20.86 in-in in 9.348 Saltbr-in 3.538 HRD-in -65.32, -50.49 69.46, 8.5 in-in-out SNCiio in-out ActLoopNT-in 3.058 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -156.23, 8.1 APE9-dihe-na -82.21, -176.47 APE8-dihe-in -53.98, 115.12 APE8-rot-in 320.45 APE67-dihe-in -72.35, -13.63 -52.11, -32.33 APE12-dist-in 7.748 APE11-dist-in 12.291 APE10-dist-out 11.219 APE9-dist-out 7.597 None None None XRAY 2.6 0.196 0.235 A 327 273 0 0 0 0 [[32, 293]] 1.0 7q7d Homo sapiens CAMK_STK17B_HUMAN CAMK 1.4e-81 279.8 4 256 253 178 179 180 182 184 62 80 84 155 157 156 158 217 205 200 199 198 197 196 195 194 111 Serine/threonine-protein kinase 17B
CAMK STK17B ST17B_HUMAN 7Q7EA O94768 25 297 372.0 ATP:60401 ATPlike Inactive DFGin 5.806 13.997 BLAminus -136.48, 179.08 63.28, 89.42 -111.5, 27.32 288.43, 87.78 -70.0, -15.51 in-in in 9.313 Saltbr-in 3.117 HRD-in -75.17, -47.59 66.91, 14.25 in-in-out SNCiio in-out ActLoopNT-in 3.4 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioo APE10-dihe-na -119.2, -9.71 APE9-dihe-na -66.55, 174.56 APE8-dihe-in -49.86, 121.22 APE8-rot-in 313.96 APE67-dihe-in -70.36, -7.82 -52.35, -34.48 APE12-dist-in 7.378 APE11-dist-in 12.111 APE10-dist-out 10.79 APE9-dist-out 7.473 None None None XRAY 2.85 0.191 0.239 A 327 273 0 0 0 0 [[32, 293]] 1.0 7q7e Homo sapiens CAMK_STK17B_HUMAN CAMK 1.4e-81 279.8 4 256 253 178 179 180 182 184 62 80 84 155 157 156 158 217 205 200 199 198 197 196 195 194 111 Serine/threonine-protein kinase 17B
CK1 TTBK1 TTBK1_HUMAN 4BTJB Q5TCY1 21 313 1321.0 ATP:61338 ATPlike Active DFGin 5.352 12.718 BLAminus -122.53, 168.88 60.17, 88.3 -98.51, 13.52 307.1, 115.33 -64.8, -32.06 in-in in 7.148 Saltbr-in 2.816 HRD-in -78.94, -51.75 72.7, -0.47 in-in-in SNCiii in-in ActLoopNT-in 2.748 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -105.82, -14.94 APE9-dihe-na -62.51, -161.18 APE8-dihe-in -100.71, 125.28 APE8-rot-in 309.68 APE67-dihe-in -55.66, -43.07 -52.23, -50.62 APE12-dist-in 11.078 APE11-dist-in 10.816 APE10-dist-in 6.463 APE9-dist-in 4.328 None None None XRAY 2.16 0.179 0.197 B 337 293 0 0 0 0 [[34, 295]] 1.0 4btj Homo sapiens CK1_TTBK1_HUMAN CK1 5.7e-105 356.4 1 262 262 175 176 177 179 181 63 77 81 151 153 152 154 221 209 204 203 202 201 200 199 198 108 Tau-tubulin kinase 1
CMGC CDK2 CDK2_HUMAN 4EOOA P24941 1 297 298.0 ATP:60302 ATPlike Inactive DFGin 6.651 15.121 BLAminus -137.3, -178.29 51.93, 74.48 -88.78, 23.73 283.58, 71.37 -66.89, -17.34 in-in in 8.754 Saltbr-in 2.774 HRD-in -82.21, -55.51 72.81, 10.91 in-in-out SNCiio in-out ActLoopNT-in 2.878 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.74, 151.81 APE9-dihe-na 71.22, 125.56 APE8-dihe-in -63.52, 145.17 APE8-rot-out 106.26 APE67-dihe-in -59.56, -25.92 -46.12, -48.45 APE12-dist-in 12.954 APE11-dist-in 10.307 APE10-dist-in 7.133 APE9-dist-in 3.247 Q131E TPO160 TPO160 XRAY 2.1 0.216 0.253 A 299 293 4 0 0 0 [[4, 286]] 1.0 4eoo Homo sapiens CMGC_CDK2_HUMAN CMGC 3.7e-90 308.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOOC P24941 1 296 298.0 ATP:60301 ATPlike Inactive DFGin 6.441 15.255 BLAminus -132.94, -176.35 50.17, 74.17 -84.23, 27.4 283.88, 71.77 -62.65, -24.02 in-in in 8.772 Saltbr-in 2.725 HRD-in -84.21, -52.66 66.89, 14.22 in-in-out SNCiio in-out ActLoopNT-in 2.986 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -124.67, 158.22 APE9-dihe-na 65.39, 129.96 APE8-dihe-in -70.44, 149.36 APE8-rot-out 84.06 APE67-dihe-in -53.86, -24.11 -49.71, -53.55 APE12-dist-in 12.807 APE11-dist-in 10.003 APE10-dist-in 6.75 APE9-dist-in 3.286 Q131E TPO160 TPO160 XRAY 2.1 0.216 0.253 C 299 296 0 0 0 0 [[4, 286]] 1.0 4eoo Homo sapiens CMGC_CDK2_HUMAN CMGC 3.7e-90 308.6 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOMA P24941 1 297 298.0 ATP:60301 ATPlike Inactive DFGin 6.766 15.173 BLAminus -135.89, -179.95 56.75, 76.33 -93.68, 18.3 281.75, 72.51 -65.02, -17.06 in-in in 8.656 Saltbr-in 2.954 HRD-in -79.7, -58.84 74.79, 7.53 in-in-out SNCiio in-out ActLoopNT-in 2.855 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na 71.17, 129.47 APE9-dihe-na 73.49, 129.68 APE8-dihe-in -66.58, 140.55 APE8-rot-out 117.21 APE67-dihe-in -54.12, -27.93 -44.4, -51.19 APE12-dist-in 13.269 APE11-dist-in 9.227 APE10-dist-in 7.153 APE9-dist-in 3.259 H84S,Q85M,Q131E TPO160 TPO160 XRAY 2.1 0.21 0.243 A 301 295 2 0 0 0 [[4, 286]] 1.0 4eom Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOMC P24941 1 296 298.0 ATP:60301 ATPlike Inactive DFGin 6.612 15.121 BLAminus -134.3, 179.46 56.9, 73.57 -89.28, 27.08 288.28, 71.72 -61.57, -29.46 in-in in 8.464 Saltbr-in 2.764 HRD-in -79.86, -55.51 70.21, 14.99 in-in-out SNCiio in-out ActLoopNT-in 2.988 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -136.3, 158.32 APE9-dihe-na 61.45, 125.91 APE8-dihe-in -61.76, 140.91 APE8-rot-out 72.97 APE67-dihe-in -49.53, -25.94 -36.27, -61.03 APE12-dist-in 12.846 APE11-dist-in 9.68 APE10-dist-in 6.944 APE9-dist-in 3.36 H84S,Q85M,Q131E TPO160 TPO160 XRAY 2.1 0.21 0.243 C 301 272 24 0 0 0 [[4, 286]] 1.0 4eom Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1FINA P24941 1 298 298.0 ATP:299 ATPlike Inactive DFGin 6.269 15.397 BLAminus -145.66, 175.42 60.17, 70.41 -88.62, 22.31 287.3, 65.31 -62.81, -23.63 in-in in 8.878 Saltbr-in 3.066 HRD-in -75.81, -52.6 66.76, 11.52 in-in-out SNCiio in-out ActLoopNT-in 2.848 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iooi APE10-dihe-na -159.69, 149.42 APE9-dihe-na -56.35, 161.85 APE8-dihe-in -65.27, 149.59 APE8-rot-out 191.08 APE67-dihe-in -48.48, -30.03 -41.87, -56.23 APE12-dist-in 10.428 APE11-dist-out 5.924 APE10-dist-out 8.991 APE9-dist-in 4.147 None None None XRAY 2.3 0.208 999.0 A 298 298 0 0 0 0 [[4, 286]] 1.0 1fin Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1FINC P24941 1 298 298.0 ATP:299 ATPlike Inactive DFGin 6.329 16.114 BLAminus -126.26, 177.09 60.06, 80.37 -100.41, 24.94 280.63, 71.46 -64.88, -37.23 in-in in 9.234 Saltbr-in 3.016 HRD-in -71.64, -45.48 67.73, -0.73 in-in-out SNCiio in-out ActLoopNT-in 2.657 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iooi APE10-dihe-na -100.08, 164.84 APE9-dihe-na -64.11, 161.66 APE8-dihe-in -58.82, 141.21 APE8-rot-in 296.75 APE67-dihe-in -52.5, -36.66 -49.82, -46.41 APE12-dist-in 10.426 APE11-dist-out 6.239 APE10-dist-out 9.723 APE9-dist-in 3.907 None None None XRAY 2.3 0.208 999.0 C 298 298 0 0 0 0 [[4, 286]] 1.0 1fin Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1FQ1B P24941 1 296 298.0 ATP:381 ATPlike Inactive DFGin 6.774 15.622 BLAminus -151.24, -169.54 37.68, 67.63 -81.17, 26.85 274.26, 50.62 -66.75, -18.36 in-out in 9.807 Saltbr-out 3.73 HRD-in -76.57, -60.94 80.93, -25.61 out-in-out SNCoio in-out ActLoopNT-in 2.61 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oioo APE10-dihe-na -104.21, 92.46 APE9-dihe-na -93.56, -175.8 APE8-dihe-out -64.18, -46.74 APE8-rot-in 317.22 APE67-dihe-out -56.53, -27.84 69.72, -12.02 APE12-dist-out 16.113 APE11-dist-in 11.902 APE10-dist-out 15.594 APE9-dist-out 10.131 None TPO160 TPO160 XRAY 3.0 0.235 0.313 B 298 296 0 0 0 0 [[4, 286]] 1.0 1fq1 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1JSTA P24941 1 298 298.0 ATP:300 ATPlike Active DFGin 6.427 15.464 BLAminus -139.88, 179.46 48.93, 78.76 -92.24, 30.29 284.11, 71.63 -70.08, -30.4 in-in in 8.717 Saltbr-in 2.757 HRD-in -78.76, -47.67 60.69, 17.81 in-in-in SNCiii in-in ActLoopNT-in 2.949 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.53, 164.64 APE9-dihe-na 80.72, 135.16 APE8-dihe-in -62.71, 138.95 APE8-rot-in 293.52 APE67-dihe-in -51.22, -30.94 -33.79, -62.16 APE12-dist-in 13.121 APE11-dist-in 11.934 APE10-dist-in 7.067 APE9-dist-in 3.277 None TPO160 TPO160 XRAY 2.6 0.2 999.0 A 298 298 0 0 0 0 [[4, 286]] 1.0 1jst Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1JSTC P24941 1 298 298.0 ATP:300 ATPlike Active DFGin 6.225 15.133 BLAminus -133.76, 179.75 53.92, 86.29 -100.05, 15.63 279.16, 71.07 -59.91, -21.96 in-in in 8.679 Saltbr-in 2.947 HRD-in -76.84, -49.3 61.77, 13.04 in-in-in SNCiii in-in ActLoopNT-in 2.701 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.31, -163.7 APE9-dihe-na 66.67, 148.27 APE8-dihe-in -72.61, 126.34 APE8-rot-in 301.65 APE67-dihe-in -51.49, -27.24 -26.21, -64.21 APE12-dist-in 13.412 APE11-dist-in 12.741 APE10-dist-in 6.942 APE9-dist-in 3.204 None TPO160 TPO160 XRAY 2.6 0.2 999.0 C 298 298 0 0 0 0 [[4, 286]] 1.0 1jst Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2CJMA P24941 1 292 298.0 ATP:1294 ATPlike Active DFGin 6.412 15.477 BLAminus -133.49, 174.28 59.08, 80.72 -93.05, 17.33 280.25, 71.88 -51.1, -37.87 in-in in 8.875 Saltbr-in 3.027 HRD-in -83.77, -55.33 74.52, 15.85 in-in-in SNCiii in-in ActLoopNT-in 2.796 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.97, -48.89 APE9-dihe-na -98.03, 148.0 APE8-dihe-in -53.4, 136.55 APE8-rot-in 296.67 APE67-dihe-in -56.28, -31.52 -52.78, -45.83 APE12-dist-in 13.329 APE11-dist-in 10.553 APE10-dist-in 7.18 APE9-dist-in 3.464 None PTR15,TPO160 PTR15,TPO160 XRAY 2.3 0.204 0.265 A 298 287 5 0 0 0 [[4, 286]] 1.0 2cjm Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2CJMC P24941 1 297 298.0 ATP:1298 ATPlike Active DFGin 6.446 15.389 BLAminus -136.23, -173.15 48.46, 78.84 -90.01, 21.15 280.3, 74.36 -53.78, -24.47 in-in in 8.957 Saltbr-in 2.575 HRD-in -82.67, -49.67 67.53, 9.26 in-in-in SNCiii in-in ActLoopNT-in 2.979 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -112.3, -72.35 APE9-dihe-na -81.21, 139.76 APE8-dihe-in -48.67, 128.86 APE8-rot-in 299.02 APE67-dihe-in -54.58, -22.4 -47.31, -51.92 APE12-dist-in 13.068 APE11-dist-in 10.808 APE10-dist-in 7.009 APE9-dist-in 3.58 None PTR15,TPO160 PTR15,TPO160 XRAY 2.3 0.204 0.265 C 298 297 0 0 0 0 [[4, 286]] 1.0 2cjm Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1GY3A P24941 1 296 298.0 ATP:1297 ATPlike Active DFGin 6.711 15.739 BLAminus -148.85, -171.85 44.28, 78.14 -91.55, 12.53 280.84, 73.84 -49.56, -35.56 in-in in 8.826 Saltbr-in 2.87 HRD-in -78.88, -56.55 74.04, 15.78 in-in-in SNCiii in-in ActLoopNT-in 3.129 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.01, 152.98 APE9-dihe-na 75.99, 139.26 APE8-dihe-in -71.28, 139.34 APE8-rot-in 297.69 APE67-dihe-in -59.44, -30.42 -47.65, -49.93 APE12-dist-in 13.156 APE11-dist-in 10.678 APE10-dist-in 7.643 APE9-dist-in 3.395 None TPO160 TPO160 XRAY 2.7 0.25 0.313 A 299 296 0 0 0 0 [[4, 286]] 1.0 1gy3 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1GY3C P24941 1 296 298.0 ATP:1298 ATPlike Active DFGin 6.824 15.376 BLAminus -159.42, -172.39 46.56, 69.8 -88.25, 18.8 278.1, 68.22 -63.28, -3.45 in-in in 8.61 Saltbr-in 3.316 HRD-in -72.89, -69.46 86.12, 7.32 in-in-in SNCiii in-in ActLoopNT-in 2.794 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.99, 145.31 APE9-dihe-na 77.28, 144.74 APE8-dihe-in -75.96, 137.92 APE8-rot-in 277.1 APE67-dihe-in -64.24, -30.46 -41.97, -49.4 APE12-dist-in 13.195 APE11-dist-in 10.636 APE10-dist-in 7.772 APE9-dist-in 3.212 None TPO160 TPO160 XRAY 2.7 0.25 0.313 C 299 296 0 0 0 0 [[4, 286]] 1.0 1gy3 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1QMZA P24941 1 296 298.0 ATP:60381 ATPlike Active DFGin 6.424 15.17 BLAminus -146.26, -172.65 47.53, 78.45 -93.94, 24.34 280.23, 76.95 -74.2, -4.32 in-in in 8.74 Saltbr-in 2.663 HRD-in -79.61, -61.2 70.52, 19.43 in-in-in SNCiii in-in ActLoopNT-in 2.981 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.31, 152.76 APE9-dihe-na 72.53, 130.75 APE8-dihe-in -60.65, 130.8 APE8-rot-in 293.88 APE67-dihe-in -60.7, -26.37 -33.48, -54.72 APE12-dist-in 13.02 APE11-dist-in 10.095 APE10-dist-in 7.17 APE9-dist-in 3.235 None TPO160 TPO160 XRAY 2.2 0.22 0.28 A 299 296 0 0 0 0 [[4, 286]] 1.0 1qmz Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1QMZC P24941 1 296 298.0 ATP:60381 ATPlike Active DFGin 6.512 15.134 BLAminus -147.61, -169.98 41.15, 80.53 -95.52, 25.6 283.09, 73.82 -79.03, -0.31 in-in in 8.74 Saltbr-in 2.54 HRD-in -75.88, -57.22 71.34, 18.39 in-in-in SNCiii in-in ActLoopNT-in 2.993 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.04, 148.92 APE9-dihe-na 73.46, 130.58 APE8-dihe-in -61.75, 132.61 APE8-rot-in 296.97 APE67-dihe-in -70.09, -17.52 -37.4, -48.3 APE12-dist-in 12.947 APE11-dist-in 10.103 APE10-dist-in 7.19 APE9-dist-in 3.234 None TPO160 TPO160 XRAY 2.2 0.22 0.28 C 299 296 0 0 0 0 [[4, 286]] 1.0 1qmz Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2CCHA P24941 1 296 298.0 ATP:61297 ATPlike Active DFGin 6.648 15.496 BLAminus -138.14, 178.31 65.58, 62.78 -86.23, 16.74 281.6, 70.81 -63.75, -23.41 in-in in 8.795 Saltbr-in 2.828 HRD-in -78.21, -56.44 71.04, 15.24 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.4, 152.64 APE9-dihe-na 69.68, 132.94 APE8-dihe-in -57.07, 137.05 APE8-rot-in 294.63 APE67-dihe-in -60.03, -20.02 -46.03, -52.89 APE12-dist-in 13.198 APE11-dist-in 10.36 APE10-dist-in 7.208 APE9-dist-in 3.286 None TPO160 TPO160 XRAY 1.7 0.15 0.182 A 299 296 0 0 0 0 [[4, 286]] 1.0 2cch Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2CCHC P24941 1 296 298.0 ATP:61297 ATPlike Active DFGin 6.477 15.382 BLAminus -137.71, -178.58 51.07, 78.61 -96.17, 22.01 279.1, 72.77 -65.43, -25.94 in-in in 8.653 Saltbr-in 2.719 HRD-in -81.45, -53.09 63.51, 17.55 in-in-in SNCiii in-in ActLoopNT-in 2.886 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.56, 136.55 APE9-dihe-na 76.27, 128.23 APE8-dihe-in -59.37, 134.24 APE8-rot-in 303.33 APE67-dihe-in -63.22, -26.6 -41.45, -49.27 APE12-dist-in 12.866 APE11-dist-in 10.056 APE10-dist-in 7.377 APE9-dist-in 3.26 None TPO160 TPO160 XRAY 1.7 0.15 0.182 C 299 296 0 0 0 0 [[4, 286]] 1.0 2cch Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2CCIA P24941 1 296 298.0 ATP:61297 ATPlike Active DFGin 6.459 15.372 BLAminus -128.71, -173.86 48.01, 81.43 -98.73, 25.24 282.02, 74.31 -66.86, -20.71 in-in in 8.902 Saltbr-in 3.076 HRD-in -75.27, -47.91 58.22, 13.15 in-in-in SNCiii in-in ActLoopNT-in 2.892 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.39, 140.99 APE9-dihe-na 76.14, 131.3 APE8-dihe-in -63.2, 133.24 APE8-rot-in 305.53 APE67-dihe-in -53.35, -21.65 -35.23, -63.18 APE12-dist-in 12.958 APE11-dist-in 10.323 APE10-dist-in 7.246 APE9-dist-in 3.291 None TPO160 TPO160 XRAY 2.7 0.264 0.321 A 299 296 0 0 0 0 [[4, 286]] 1.0 2cci Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 2CCIC P24941 1 296 298.0 ATP:61297 ATPlike Active DFGin 6.232 15.382 BLAminus -129.31, 167.15 64.1, 86.76 -100.18, 28.53 276.86, 72.85 -63.26, -37.36 in-in in 8.551 Saltbr-in 2.666 HRD-in -73.66, -47.99 63.69, 10.4 in-in-in SNCiii in-in ActLoopNT-in 3.064 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.2, 138.6 APE9-dihe-na 71.13, 137.9 APE8-dihe-in -63.98, 129.66 APE8-rot-in 301.4 APE67-dihe-in -61.96, -9.78 -29.15, -60.17 APE12-dist-in 12.753 APE11-dist-in 9.767 APE10-dist-in 7.42 APE9-dist-in 3.234 None TPO160 TPO160 XRAY 2.7 0.264 0.321 C 299 296 0 0 0 0 [[4, 286]] 1.0 2cci Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOQA P24941 1 297 298.0 ATP:60301 ATPlike Inactive DFGin 6.603 15.258 BLAminus -136.2, -179.04 55.17, 77.3 -91.43, 19.33 282.26, 72.55 -64.29, -18.87 in-in in 8.786 Saltbr-in 2.845 HRD-in -79.78, -53.17 69.74, 9.41 in-in-out SNCiio in-out ActLoopNT-in 2.906 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na 62.26, 128.16 APE9-dihe-na 76.05, 127.33 APE8-dihe-in -62.55, 137.94 APE8-rot-out 115.71 APE67-dihe-in -58.94, -23.33 -43.56, -48.15 APE12-dist-in 13.361 APE11-dist-in 9.158 APE10-dist-in 7.177 APE9-dist-in 3.246 None TPO160 TPO160 XRAY 2.15 0.201 0.234 A 301 294 3 0 0 0 [[4, 286]] 1.0 4eoq Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOQC P24941 1 296 298.0 ATP:60301 ATPlike Inactive DFGin 6.583 15.249 BLAminus -140.92, -177.14 51.0, 72.99 -85.26, 24.65 284.32, 71.69 -63.95, -27.55 in-in in 8.649 Saltbr-in 2.713 HRD-in -79.85, -57.3 73.26, 6.95 in-in-out SNCiio in-out ActLoopNT-in 2.949 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -135.95, 149.43 APE9-dihe-na 70.01, 126.65 APE8-dihe-in -62.68, 144.35 APE8-rot-out 86.91 APE67-dihe-in -60.3, -23.97 -41.77, -51.35 APE12-dist-in 12.923 APE11-dist-in 9.988 APE10-dist-in 7.055 APE9-dist-in 3.18 None TPO160 TPO160 XRAY 2.15 0.201 0.234 C 301 272 24 0 0 0 [[4, 286]] 1.0 4eoq Homo sapiens CMGC_CDK2_HUMAN CMGC 6.6e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOJA P24941 1 298 298.0 ATP:60301 ATPlike Inactive DFGin 6.671 15.377 BLAminus -134.08, 177.58 53.89, 78.08 -94.34, 17.78 277.91, 75.6 -65.2, -18.6 in-in in 8.642 Saltbr-in 2.923 HRD-in -77.88, -54.19 68.96, 13.72 in-in-out SNCiio in-out ActLoopNT-in 2.952 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -80.75, 158.76 APE9-dihe-na 76.84, 131.84 APE8-dihe-in -62.19, 141.78 APE8-rot-out 119.83 APE67-dihe-in -58.91, -24.4 -48.51, -47.68 APE12-dist-in 13.309 APE11-dist-in 9.149 APE10-dist-in 7.333 APE9-dist-in 3.214 H84S,Q85M,K89D TPO160 TPO160 XRAY 1.65 0.197 0.215 A 302 294 4 0 0 0 [[4, 286]] 1.0 4eoj Homo sapiens CMGC_CDK2_HUMAN CMGC 2.1e-89 306.1 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 4EOJC P24941 1 296 298.0 ATP:60301 ATPlike Inactive DFGin 6.604 15.375 BLAminus -136.46, -177.75 51.71, 75.47 -89.77, 20.18 280.05, 73.98 -59.21, -28.77 in-in in 8.59 Saltbr-in 2.63 HRD-in -79.08, -54.75 70.82, 10.21 in-in-out SNCiio in-out ActLoopNT-in 2.918 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.67, 155.4 APE9-dihe-na 67.15, 126.49 APE8-dihe-in -61.14, 141.64 APE8-rot-out 49.99 APE67-dihe-in -62.84, -21.66 -42.97, -49.5 APE12-dist-in 12.897 APE11-dist-in 9.826 APE10-dist-in 6.834 APE9-dist-in 3.184 H84S,Q85M,K89D TPO160 TPO160 XRAY 1.65 0.197 0.215 C 302 279 17 0 0 0 [[4, 286]] 1.0 4eoj Homo sapiens CMGC_CDK2_HUMAN CMGC 2.1e-89 306.1 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1HCKA P24941 1 298 298.0 ATP:400 ATPlike Inactive DFGin 10.521 18.374 BLBtrans -101.64, 156.72 59.01, 28.24 -65.02, 120.2 217.92, 114.75 87.03, -4.22 out-out out 14.886 Saltbr-out 16.602 HRD-in -89.06, -54.55 70.31, -1.71 out-out-out SNCooo out-out ActLoopNT-out 5.768 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -59.61, 130.9 APE9-dihe-na -79.22, 142.0 APE8-dihe-in -76.12, 133.01 APE8-rot-out 180.79 APE67-dihe-in -48.4, -27.96 -101.36, -7.62 APE12-dist-out 20.077 APE11-dist-out 17.599 APE10-dist-out 19.471 APE9-dist-out 11.031 None None None XRAY 1.9 0.185 0.272 A 298 294 4 0 0 0 [[4, 286]] 1.0 1hck Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 8FP5A P24941 2 298 298.0 ATP:302 ATPlike Inactive DFGin 10.376 18.32 BLBtrans -107.51, 151.36 65.27, 30.62 -67.28, 128.54 213.84, 133.39 81.57, 1.02 out-out out 15.796 Saltbr-out 15.873 HRD-in -85.24, -57.92 82.57, -13.18 out-out-out SNCooo out-out ActLoopNT-out 5.893 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -82.36, 136.98 APE9-dihe-na -71.53, 131.08 APE8-dihe-in -77.4, 124.67 APE8-rot-in 308.71 APE67-dihe-in -62.7, -24.4 -97.59, -2.61 APE12-dist-out 20.412 APE11-dist-out 17.362 APE10-dist-out 19.075 APE9-dist-out 10.919 None None None XRAY 1.7 0.196 0.23 A 298 288 9 0 0 0 [[4, 286]] 1.0 8fp5 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.3e-90 307.9 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1B38A P24941 1 298 298.0 ATP:60381 ATPlike Inactive DFGin 10.197 18.302 BLBtrans -95.65, 156.45 60.68, 25.9 -58.03, 132.69 221.26, 95.46 85.91, -14.49 out-out out 15.154 Saltbr-out 16.064 HRD-in -76.6, -58.97 89.85, -20.78 out-out-out SNCooo out-out ActLoopNT-out 6.207 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -77.95, 142.89 APE9-dihe-na -75.18, 129.36 APE8-dihe-in -71.98, 129.31 APE8-rot-out 193.64 APE67-dihe-in -51.99, -31.61 -101.67, -5.99 APE12-dist-out 19.553 APE11-dist-out 17.458 APE10-dist-out 18.673 APE9-dist-out 10.568 None None None XRAY 2.0 0.18 0.25 A 299 290 8 0 0 0 [[4, 286]] 1.0 1b38 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK2 CDK2_HUMAN 1B39A P24941 1 298 298.0 ATP:60381 ATPlike Inactive DFGin 10.534 18.343 BLBtrans -101.01, 147.7 73.19, 23.92 -63.93, 137.58 224.37, 103.76 85.74, -27.62 out-out out 15.412 Saltbr-out 16.029 HRD-in -84.44, -53.29 77.56, -15.37 out-out-out SNCooo out-out ActLoopNT-out 5.843 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -101.65, 122.32 APE9-dihe-na -57.75, 145.92 APE8-dihe-in -67.9, 142.03 APE8-rot-in 290.02 APE67-dihe-in -56.66, -23.98 -105.17, -10.65 APE12-dist-out 20.463 APE11-dist-out 17.183 APE10-dist-out 18.313 APE9-dist-out 9.98 None None None XRAY 2.1 0.2 0.27 A 299 290 8 0 0 0 [[4, 286]] 1.0 1b39 Homo sapiens CMGC_CDK2_HUMAN CMGC 6.4e-90 307.8 1 301 301 144 145 146 148 150 33 51 55 124 126 125 127 185 172 167 166 165 164 163 162 161 81 Cyclin-dependent kinase 2
CMGC CDK7 CDK7_HUMAN 1UA2A P50613 13 311 346.0 ATP:381 ATPlike Inactive DFGin 3.838 15.074 None -72.36, 176.54 -63.29, 129.93 -58.5, 61.34 34.11, 88.78 62.95, -115.18 out-out out 13.014 Saltbr-out 13.633 HRD-out -71.94, 127.86 -111.75, 17.16 out-out-out SNCooo out-out ActLoopNT-out 10.781 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -60.17, 155.77 APE9-dihe-na -94.04, -36.01 APE8-dihe-out 80.52, 83.34 APE8-rot-in 310.15 APE67-dihe-in -70.12, 0.07 -111.89, 13.44 APE12-dist-out 21.608 APE11-dist-out 18.745 APE10-dist-out 20.457 APE9-dist-out 13.019 None TPO170 TPO170 XRAY 3.02 0.217 0.288 A 346 287 13 0 0 0 [[12, 295]] 1.0 1ua2 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 1UA2B P50613 13 311 346.0 ATP:382 ATPlike Inactive DFGin 4.075 14.483 None -83.42, -165.13 -43.25, 135.34 -79.47, 27.14 49.47, 35.58 128.26, -117.59 out-out out 13.208 Saltbr-out 11.182 HRD-out -90.35, 54.77 -58.64, -3.2 out-out-out SNCooo out-out ActLoopNT-out 10.755 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -59.37, 128.97 APE9-dihe-na -70.17, -103.62 APE8-dihe-out 114.41, 132.59 APE8-rot-out 86.06 APE67-dihe-in -64.71, -6.03 -138.86, 19.47 APE12-dist-out 21.356 APE11-dist-out 17.939 APE10-dist-out 20.116 APE9-dist-out 13.119 None TPO170 TPO170 XRAY 3.02 0.217 0.288 B 346 287 13 0 0 0 [[12, 295]] 1.0 1ua2 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 1UA2C P50613 13 311 346.0 ATP:383 ATPlike Inactive DFGin 4.377 15.832 None -69.53, 164.86 -53.4, 113.84 -55.09, 81.41 35.63, 74.81 38.07, -90.08 out-out out 14.291 Saltbr-out 13.35 HRD-out -90.81, 75.3 -67.23, 24.34 out-out-out SNCooo out-out ActLoopNT-out 10.725 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oooo APE10-dihe-na -61.3, 146.02 APE9-dihe-na -103.14, 168.98 APE8-dihe-in -149.98, 115.15 APE8-rot-in 317.59 APE67-dihe-in -70.34, -0.48 -115.08, 9.43 APE12-dist-out 21.995 APE11-dist-out 19.636 APE10-dist-out 20.119 APE9-dist-out 12.619 None TPO170 TPO170 XRAY 3.02 0.217 0.288 C 346 287 13 0 0 0 [[12, 295]] 1.0 1ua2 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK7 CDK7_HUMAN 1UA2D P50613 13 311 346.0 ATP:384 ATPlike Inactive DFGin 3.971 15.482 None -66.13, 178.54 -66.01, 128.6 -62.88, 66.21 38.44, 67.87 63.18, -97.8 out-out out 13.242 Saltbr-out 13.575 HRD-out -80.45, 94.07 -71.75, -5.97 out-out-out SNCooo out-out ActLoopNT-out 10.896 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_oooo APE10-dihe-na -70.63, 129.76 APE9-dihe-na -71.09, 152.84 APE8-dihe-in -147.91, 130.69 APE8-rot-out 68.98 APE67-dihe-in -88.14, 9.58 -128.15, 23.18 APE12-dist-out 22.145 APE11-dist-out 18.845 APE10-dist-out 20.01 APE9-dist-out 12.657 None TPO170 TPO170 XRAY 3.02 0.217 0.288 D 346 287 13 0 0 0 [[12, 295]] 1.0 1ua2 Homo sapiens CMGC_CDK7_HUMAN CMGC 1.6e-78 271.8 1 301 301 154 155 156 158 160 41 62 66 134 136 135 137 195 182 177 176 175 174 173 172 171 92 Cyclin-dependent kinase 7
CMGC CDK9 CDK9_HUMAN 3BLQA P50750 7 325 372.0 ATP:332 ATPlike Active DFGin 6.983 15.235 BLAminus -137.33, 167.71 61.72, 82.78 -101.54, 27.58 292.13, 71.79 -68.35, -20.47 in-in in 9.514 Saltbr-in 3.257 HRD-in -70.77, -57.41 73.91, 6.35 in-in-in SNCiii in-in ActLoopNT-in 2.85 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -129.28, 155.2 APE9-dihe-na 75.14, 129.25 APE8-dihe-in -51.14, 147.2 APE8-rot-in 304.68 APE67-dihe-in -62.86, -25.73 -50.2, -49.1 APE12-dist-in 13.028 APE11-dist-in 11.03 APE10-dist-in 6.896 APE9-dist-in 3.154 None TPO186 TPO186 XRAY 2.9 0.174 0.234 A 331 296 23 0 0 7 [[19, 315]] 1.0 3blq Homo sapiens CMGC_CDK9_HUMAN CMGC 4.1e-80 275.1 1 301 301 166 167 168 170 172 48 66 70 146 148 147 149 211 198 193 192 191 190 189 188 187 104 Cyclin-dependent kinase 9
CMGC CSNK2A1 CSK21_HUMAN 5CU6A P68400 3 329 391.0 ATP:401 ATPlike Active DFGin 7.373 16.301 BLAminus -117.96, -176.97 52.74, 80.35 -94.88, 19.06 296.35, 83.62 -69.11, -18.98 in-in in 9.296 Saltbr-in 2.997 HRD-in -73.54, -48.21 69.17, 10.55 in-in-in SNCiii in-in ActLoopNT-in 2.894 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.92, 173.11 APE9-dihe-na 58.61, 170.65 APE8-dihe-in -94.81, 150.1 APE8-rot-in 295.17 APE67-dihe-in -71.66, -13.32 -37.08, -56.84 APE12-dist-in 12.652 APE11-dist-in 10.334 APE10-dist-in 6.182 APE9-dist-in 3.146 R21S,K74A,K75A,K76A None None XRAY 1.36 0.188 0.209 A 328 327 0 0 0 0 [[39, 324]] 1.0 5cu6 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZYDA P68400 3 329 391.0 ATP:403,KD6:404 ATPlike,Allosteric Active DFGin 7.329 16.214 BLAminus -118.97, -177.69 55.36, 75.35 -91.38, 15.36 296.7, 79.46 -65.95, -20.35 in-in in 9.271 Saltbr-in 2.864 HRD-in -76.19, -47.14 68.74, 13.25 in-in-in SNCiii in-in ActLoopNT-in 2.861 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.11, 172.03 APE9-dihe-na 59.78, 163.78 APE8-dihe-in -88.12, 149.21 APE8-rot-in 297.74 APE67-dihe-in -70.35, -14.8 -37.52, -55.55 APE12-dist-in 12.665 APE11-dist-in 10.191 APE10-dist-in 6.197 APE9-dist-in 3.192 R21S,K74A,K75A,K76A None None XRAY 1.404 0.199 0.214 A 328 327 0 0 0 0 [[39, 324]] 1.0 7zyd Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZYRA P68400 3 329 391.0 ATP:401,KF6:406 ATPlike,Allosteric Active DFGin 7.384 16.336 BLAminus -115.5, -176.17 54.52, 75.81 -90.94, 15.84 295.5, 83.13 -67.01, -21.05 in-in in 9.3 Saltbr-in 3.067 HRD-in -73.81, -46.94 67.44, 10.6 in-in-in SNCiii in-in ActLoopNT-in 2.962 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.26, 163.7 APE9-dihe-na 66.11, 155.14 APE8-dihe-in -79.05, 149.29 APE8-rot-in 297.87 APE67-dihe-in -66.86, -16.16 -37.19, -56.72 APE12-dist-in 12.649 APE11-dist-in 10.272 APE10-dist-in 6.096 APE9-dist-in 3.282 R21S,K74A,K75A,K76A None None XRAY 1.85 0.17 0.209 A 328 327 0 0 0 0 [[39, 324]] 1.0 7zyr Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 8AECA P68400 3 329 391.0 ATP:401,LW3:404 ATPlike,Allosteric Inactive DFGin 7.176 16.144 BLAminus -118.04, -179.83 50.85, 85.39 -95.14, 14.95 295.73, 81.33 -66.57, -20.11 in-in in 9.263 Saltbr-in 2.828 HRD-in -74.16, -49.17 69.92, 11.72 in-in-out SNCiio in-out ActLoopNT-in 2.841 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.03, 173.8 APE9-dihe-na 56.87, 164.78 APE8-dihe-in -92.58, 150.13 APE8-rot-out 58.14 APE67-dihe-in -68.24, -15.5 -36.53, -56.67 APE12-dist-in 12.634 APE11-dist-in 10.289 APE10-dist-in 6.179 APE9-dist-in 3.113 R21S,K74A,K75A,K76A None None XRAY 1.09 0.196 0.209 A 328 327 0 0 0 0 [[39, 324]] 1.0 8aec Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OSPA P68400 3 329 391.0 ATP:401,A9W:406 ATPlike,Allosteric Active DFGin 7.448 16.259 BLAminus -112.91, -173.94 47.41, 80.27 -93.43, 19.44 295.5, 80.71 -64.79, -26.04 in-in in 9.236 Saltbr-in 2.811 HRD-in -68.59, -50.2 68.38, 8.36 in-in-in SNCiii in-in ActLoopNT-in 2.961 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.65, 166.65 APE9-dihe-na 64.03, 159.2 APE8-dihe-in -80.26, 148.93 APE8-rot-in 296.57 APE67-dihe-in -70.89, -16.0 -37.06, -53.51 APE12-dist-in 12.712 APE11-dist-in 10.365 APE10-dist-in 6.135 APE9-dist-in 3.332 R21S,K74A,K75A,K76A None None XRAY 1.91 0.174 0.213 A 342 327 0 0 0 0 [[39, 324]] 1.0 5osp Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 9.4e-69 237.9 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OSRA P68400 3 329 391.0 ATP:403,AFK:404 ATPlike,Allosteric Active DFGin 7.39 16.235 BLAminus -115.2, -175.48 53.01, 75.53 -91.02, 17.2 296.18, 83.93 -66.77, -22.5 in-in in 9.17 Saltbr-in 2.886 HRD-in -76.06, -46.71 67.27, 11.5 in-in-in SNCiii in-in ActLoopNT-in 2.902 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.95, 170.87 APE9-dihe-na 60.56, 162.64 APE8-dihe-in -87.43, 145.48 APE8-rot-in 300.92 APE67-dihe-in -69.88, -13.97 -33.79, -56.46 APE12-dist-in 12.727 APE11-dist-in 10.365 APE10-dist-in 6.184 APE9-dist-in 3.167 R21S,K74A,K75A,K76A None None XRAY 1.57 0.177 0.209 A 342 327 0 0 0 0 [[39, 324]] 1.0 5osr Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 9.4e-69 237.9 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZY2A P68400 3 329 391.0 ATP:401,H4N:404,H4N:405 ATPlike,Allosteric,Allosteric Active DFGin 7.467 16.28 BLAminus -114.82, -177.5 55.14, 73.38 -87.5, 13.22 295.06, 80.66 -60.96, -25.13 in-in in 9.251 Saltbr-in 2.931 HRD-in -72.23, -48.39 67.99, 7.65 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.44, 169.73 APE9-dihe-na 59.19, 155.39 APE8-dihe-in -76.55, 147.29 APE8-rot-in 280.93 APE67-dihe-in -68.75, -13.44 -39.25, -54.49 APE12-dist-in 12.699 APE11-dist-in 10.36 APE10-dist-in 6.164 APE9-dist-in 3.268 R21S,K74A,K75A,K76A None None XRAY 1.51 0.189 0.21 A 328 327 0 0 0 0 [[39, 324]] 1.0 7zy2 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 7ZYOA P68400 3 329 391.0 ATP:401,KEX:404,KEX:405 ATPlike,Allosteric,Allosteric Active DFGin 7.502 16.398 BLAminus -113.84, -177.01 53.93, 77.01 -92.97, 16.97 297.5, 80.44 -65.6, -20.61 in-in in 9.197 Saltbr-in 2.93 HRD-in -77.03, -47.55 70.73, 4.92 in-in-in SNCiii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.4, 169.84 APE9-dihe-na 59.33, 166.07 APE8-dihe-in -87.44, 145.03 APE8-rot-in 291.2 APE67-dihe-in -67.16, -16.67 -36.15, -55.82 APE12-dist-in 12.756 APE11-dist-in 10.601 APE10-dist-in 6.194 APE9-dist-in 3.221 R21S,K74A,K75A,K76A None None XRAY 1.58 0.176 0.204 A 328 327 0 0 0 0 [[39, 324]] 1.0 7zyo Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OS7B P68400 3 327 391.0 A8Q:402,ATP:403 Allosteric,ATPlike Active DFGin 7.403 16.286 BLAminus -113.36, -175.81 49.81, 80.69 -97.06, 16.82 294.27, 80.08 -65.25, -22.08 in-in in 9.411 Saltbr-in 2.797 HRD-in -70.47, -48.19 65.29, 14.71 in-in-in SNCiii in-in ActLoopNT-in 2.857 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.46, 173.88 APE9-dihe-na 61.83, 168.57 APE8-dihe-in -97.24, 140.84 APE8-rot-in 297.98 APE67-dihe-in -62.16, -22.89 -29.44, -59.48 APE12-dist-in 12.639 APE11-dist-in 10.371 APE10-dist-in 6.029 APE9-dist-in 3.111 R21S None None XRAY 1.66 0.222 0.247 B 352 325 0 0 0 0 [[39, 324]] 1.0 5os7 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6GMDA P68400 3 327 391.0 A8Q:402,ATP:403 Allosteric,ATPlike Active DFGin 7.403 16.286 BLAminus -113.36, -175.81 49.81, 80.69 -97.06, 16.82 294.27, 80.08 -65.25, -22.08 in-in in 9.411 Saltbr-in 2.797 HRD-in -70.47, -48.19 65.29, 14.71 in-in-in SNCiii in-in ActLoopNT-in 2.857 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -130.46, 173.88 APE9-dihe-na 61.83, 168.57 APE8-dihe-in -97.24, 140.84 APE8-rot-in 297.98 APE67-dihe-in -62.16, -21.58 -29.44, -59.48 APE12-dist-in 12.639 APE11-dist-in 10.371 APE10-dist-in 6.029 APE9-dist-in 3.111 R21S None None XRAY 1.66 0.222 0.247 A 352 325 0 0 0 0 [[39, 324]] 1.0 6gmd Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5CVFA P68400 3 329 391.0 54Z:401,ATP:402 Allosteric,ATPlike Active DFGin 7.47 16.268 BLAminus -117.2, -174.73 54.63, 71.77 -90.8, 22.72 298.48, 81.13 -69.82, -23.93 in-in in 9.281 Saltbr-in 2.82 HRD-in -73.12, -49.94 68.07, 7.39 in-in-in SNCiii in-in ActLoopNT-in 2.918 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.49, 166.86 APE9-dihe-na 61.99, 156.53 APE8-dihe-in -74.21, 147.85 APE8-rot-in 294.94 APE67-dihe-in -65.44, -19.86 -39.38, -55.54 APE12-dist-in 12.666 APE11-dist-in 10.304 APE10-dist-in 6.173 APE9-dist-in 3.251 R21S,K74A,K75A,K76A None None XRAY 1.63 0.201 0.209 A 328 325 2 0 0 0 [[39, 324]] 1.0 5cvf Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6FVFA P68400 3 329 391.0 503:401,ATP:402 Allosteric,ATPlike Inactive DFGin 7.458 15.996 BLAminus -117.08, -172.6 51.64, 74.63 -91.13, 21.7 296.66, 78.77 -67.99, -24.04 in-in in 9.37 Saltbr-in 2.804 HRD-in -73.47, -46.21 64.83, 11.56 in-in-out SNCiio in-out ActLoopNT-in 2.86 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.11, 170.35 APE9-dihe-na 60.67, 163.08 APE8-dihe-in -84.61, 146.09 APE8-rot-out 196.52 APE67-dihe-in -71.22, -11.21 -34.5, -54.96 APE12-dist-in 12.745 APE11-dist-in 10.441 APE10-dist-in 6.28 APE9-dist-in 3.131 R21S,K74A,K75A,K76A None None XRAY 1.47 0.201 0.222 A 328 327 0 0 0 0 [[39, 324]] 1.0 6fvf Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6FVGA P68400 3 329 391.0 E8K:401,ATP:402 Allosteric,ATPlike Inactive DFGin 7.564 16.249 BLAminus -114.12, -177.27 49.95, 79.39 -92.46, 19.09 295.44, 80.72 -62.08, -29.09 in-in in 9.471 Saltbr-in 2.867 HRD-in -71.26, -47.89 65.91, 11.22 in-in-out SNCiio in-out ActLoopNT-in 2.92 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -131.37, 168.11 APE9-dihe-na 62.71, 167.0 APE8-dihe-in -87.82, 142.1 APE8-rot-out 201.01 APE67-dihe-in -70.04, -16.46 -32.6, -53.52 APE12-dist-in 12.902 APE11-dist-in 10.544 APE10-dist-in 6.345 APE9-dist-in 3.208 R21S,K74A,K75A,K76A None None XRAY 1.6 0.208 0.229 A 328 327 0 0 0 0 [[39, 324]] 1.0 6fvg Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 8AEKA P68400 3 329 391.0 LVL:401,ATP:402 Allosteric,ATPlike Active DFGin 7.359 16.189 BLAminus -116.05, -177.84 59.67, 69.99 -88.27, 14.27 295.52, 85.07 -64.38, -21.31 in-in in 9.205 Saltbr-in 2.816 HRD-in -74.44, -47.13 67.98, 9.84 in-in-in SNCiii in-in ActLoopNT-in 2.928 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.41, 169.56 APE9-dihe-na 60.21, 157.69 APE8-dihe-in -79.56, 148.43 APE8-rot-in 292.83 APE67-dihe-in -70.07, -13.69 -40.23, -52.63 APE12-dist-in 12.638 APE11-dist-in 10.319 APE10-dist-in 6.099 APE9-dist-in 3.21 R21S,K74A,K75A,K76A None None XRAY 1.65 0.173 0.198 A 328 327 0 0 0 0 [[39, 324]] 1.0 8aek Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 8AEMA P68400 3 329 391.0 LVF:407,ATP:408 Allosteric,ATPlike Active DFGin 7.399 16.187 BLAminus -114.2, -178.47 56.21, 75.05 -90.39, 15.9 296.69, 81.8 -66.43, -20.83 in-in in 9.132 Saltbr-in 2.816 HRD-in -72.91, -51.16 68.69, 11.11 in-in-in SNCiii in-in ActLoopNT-in 2.905 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -131.83, 169.06 APE9-dihe-na 58.87, 157.76 APE8-dihe-in -77.1, 150.54 APE8-rot-in 294.73 APE67-dihe-in -68.78, -13.55 -40.19, -53.95 APE12-dist-in 12.744 APE11-dist-in 10.417 APE10-dist-in 6.256 APE9-dist-in 3.215 R21S,K74A,K75A,K76A None None XRAY 1.6 0.19 0.212 A 328 327 0 0 0 0 [[39, 324]] 1.0 8aem Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5CSHA P68400 4 327 391.0 54E:401,54E:402,ATP:403 Allosteric,Allosteric,ATPlike Active DFGin 7.436 16.475 BLAminus -114.33, -175.52 50.17, 77.83 -91.69, 16.93 295.31, 78.96 -64.52, -21.3 in-in in 9.606 Saltbr-in 2.798 HRD-in -72.7, -45.69 67.95, 9.72 in-in-in SNCiii in-in ActLoopNT-in 2.962 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.3, 172.6 APE9-dihe-na 60.22, 166.59 APE8-dihe-in -92.85, 140.16 APE8-rot-in 301.7 APE67-dihe-in -64.39, -20.56 -30.14, -59.7 APE12-dist-in 12.508 APE11-dist-in 10.286 APE10-dist-in 6.015 APE9-dist-in 3.087 R21S None None XRAY 1.59 0.194 0.207 A 352 324 0 0 0 0 [[39, 324]] 1.0 5csh Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5CSHB P68400 2 328 391.0 54E:403,54E:404,ATP:405 Allosteric,Allosteric,ATPlike Active DFGin 7.443 16.293 BLAminus -115.21, -175.71 50.61, 77.51 -92.19, 18.86 294.88, 77.24 -65.62, -21.94 in-in in 9.366 Saltbr-in 2.774 HRD-in -75.48, -46.24 69.71, 9.97 in-in-in SNCiii in-in ActLoopNT-in 2.989 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.44, 174.47 APE9-dihe-na 60.65, 166.44 APE8-dihe-in -96.7, 141.75 APE8-rot-in 305.79 APE67-dihe-in -65.63, -20.28 -30.96, -58.74 APE12-dist-in 12.584 APE11-dist-in 10.424 APE10-dist-in 6.071 APE9-dist-in 3.124 R21S None None XRAY 1.59 0.194 0.207 B 352 323 4 0 0 0 [[39, 324]] 1.0 5csh Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OS7A P68400 3 328 391.0 A8Q:404,A8Q:405,ATP:406 Allosteric,Allosteric,ATPlike Active DFGin 7.464 16.089 BLAminus -111.7, -175.06 51.27, 78.03 -95.04, 15.76 293.36, 80.0 -65.49, -19.43 in-in in 9.208 Saltbr-in 2.758 HRD-in -69.55, -50.38 66.74, 15.37 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.67, 175.58 APE9-dihe-na 57.11, 170.24 APE8-dihe-in -96.94, 142.73 APE8-rot-in 298.08 APE67-dihe-in -63.57, -23.25 -31.45, -59.13 APE12-dist-in 12.662 APE11-dist-in 10.379 APE10-dist-in 6.175 APE9-dist-in 3.132 R21S None None XRAY 1.66 0.222 0.247 A 352 326 0 0 0 0 [[39, 324]] 1.0 5os7 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 6GMDB P68400 3 328 391.0 A8Q:404,A8Q:405,ATP:406 Allosteric,Allosteric,ATPlike Active DFGin 7.464 16.089 BLAminus -111.7, -175.06 51.27, 78.03 -95.04, 15.76 293.36, 80.0 -65.49, -19.43 in-in in 9.208 Saltbr-in 2.758 HRD-in -69.55, -50.38 66.74, 15.37 in-in-in SNCiii in-in ActLoopNT-in 2.878 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.67, 175.58 APE9-dihe-na 57.11, 170.24 APE8-dihe-in -96.94, 142.73 APE8-rot-in 298.08 APE67-dihe-in -63.57, -23.25 -31.45, -59.13 APE12-dist-in 12.662 APE11-dist-in 10.379 APE10-dist-in 6.175 APE9-dist-in 3.132 R21S None None XRAY 1.66 0.222 0.247 B 352 326 0 0 0 0 [[39, 324]] 1.0 6gmd Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 1.6e-69 240.4 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OS8A P68400 3 329 391.0 J27:404,J27:405,J27:406,ATP:407 Allosteric,Allosteric,Allosteric,ATPlike Active DFGin 7.45 16.146 BLAminus -116.36, -176.24 53.52, 76.44 -92.27, 17.36 295.25, 83.47 -66.45, -20.94 in-in in 9.232 Saltbr-in 2.789 HRD-in -76.31, -47.96 70.56, 8.8 in-in-in SNCiii in-in ActLoopNT-in 2.902 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -134.3, 166.93 APE9-dihe-na 62.26, 151.31 APE8-dihe-in -76.68, 145.67 APE8-rot-in 296.22 APE67-dihe-in -69.08, -13.55 -36.03, -55.39 APE12-dist-in 12.667 APE11-dist-in 10.309 APE10-dist-in 6.187 APE9-dist-in 3.313 R21S,K74A,K75A,K76A None None XRAY 1.55 0.178 0.201 A 328 327 0 0 0 0 [[39, 324]] 1.0 5os8 Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 8.1e-69 238.0 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
CMGC CSNK2A1 CSK21_HUMAN 5OTRA P68400 3 329 391.0 AU8:403,AU8:404,AU8:405,ATP:406 Allosteric,Allosteric,Allosteric,ATPlike Active DFGin 7.468 16.282 BLAminus -118.34, -175.14 53.67, 73.1 -89.26, 15.26 295.08, 81.83 -61.86, -25.81 in-in in 9.365 Saltbr-in 2.951 HRD-in -75.87, -45.88 70.89, 5.51 in-in-in SNCiii in-in ActLoopNT-in 2.912 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -128.59, 162.52 APE9-dihe-na 63.44, 152.89 APE8-dihe-in -75.69, 144.57 APE8-rot-in 311.11 APE67-dihe-in -70.25, -15.02 -34.48, -55.38 APE12-dist-in 12.809 APE11-dist-in 10.57 APE10-dist-in 6.339 APE9-dist-in 3.607 R21S,K74A,K75A,K76A None None XRAY 1.52 0.18 0.202 A 342 327 0 0 0 0 [[39, 324]] 1.0 5otr Homo sapiens CMGC_CSNK2A1_HUMAN CMGC 9.4e-69 237.9 1 301 301 174 175 176 178 180 68 81 85 153 155 154 156 214 201 196 195 194 193 192 191 190 114 Casein kinase II subunit alpha
OTHER TTK TTK_HUMAN 3HMNA P33981 516 794 857.0 ATP:1 ATPlike Inactive DFGin 3.999 14.991 ABAminus -98.05, -9.81 -153.31, 160.67 -110.5, 6.35 307.22, 150.55 69.66, 19.48 out-out out 10.962 Saltbr-out 6.528 HRD-in -68.45, -50.57 72.29, 2.18 out-out-out SNCooo out-out ActLoopNT-out 11.646 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_nnoo APE10-dihe-na 999.0, 102.39 APE9-dihe-na -78.34, -151.63 APE8-dihe-in -168.7, 144.18 APE8-rot-in 299.37 APE67-dihe-in -66.82, -19.22 -122.77, 14.51 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.622 APE9-dist-out 12.191 None None None XRAY 2.7 0.223 0.265 A 342 255 24 0 0 12 [[525, 791]] 1.0 3hmn Homo sapiens OTHER_TTK_HUMAN CAMK 1.1e-53 188.1 1 256 256 663 664 665 667 669 553 571 575 644 646 645 647 716 693 688 687 686 685 684 683 682 603 Dual specificity protein kinase TTK
RGC NPR1 ANPRA_HUMAN 9BCOA P16066 498 1053 1061.0 ATP:61101 ATPlike Pseudo DFGin 6.5 14.828 BLBplus -89.25, -164.06 42.72, 55.71 -135.24, 156.32 73.6, 95.91 78.22, -166.07 out-none out 16.928 Saltbr-none 999.0 HRD-out -74.2, 156.17 -59.96, -57.76 none-out-out SNCnoo out-out ActLoopNT-out 12.014 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -68.12, -1.53 APE9-dihe-na -60.93, -51.9 APE8-dihe-in -129.45, 85.23 APE8-rot-none 999.0 APE67-dihe-in -58.29, -38.75 -145.34, 13.28 APE12-dist-out 23.574 APE11-dist-out 20.43 APE10-dist-out 24.55 APE9-dist-out 15.858 None None None EM 4.4 999.0 999.0 A 1040 521 21 0 0 0 [[539, 803]] 1.0 9bco Homo sapiens RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6 265 260 677 678 679 681 683 567 583 587 657 659 658 660 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCOB P16066 501 1053 1061.0 ATP:61101 ATPlike Pseudo DFGin 6.035 14.05 BLBplus -88.95, 166.99 56.44, 21.66 -61.11, 145.38 64.96, 87.18 86.53, -116.67 out-none out 15.454 Saltbr-none 999.0 HRD-in -114.17, -53.78 98.92, -43.57 none-out-out SNCnoo out-out ActLoopNT-out 9.447 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_oooo APE10-dihe-na -52.94, -51.71 APE9-dihe-na -111.55, -27.36 APE8-dihe-out -110.69, 11.24 APE8-rot-none 999.0 APE67-dihe-in -47.42, -35.74 -121.93, -1.95 APE12-dist-out 18.204 APE11-dist-out 21.211 APE10-dist-out 24.218 APE9-dist-out 14.706 None None None EM 4.4 999.0 999.0 B 1040 517 22 0 0 0 [[539, 803]] 1.0 9bco Homo sapiens RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6 265 260 677 678 679 681 683 567 583 587 657 659 658 660 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCPA P16066 505 842 1061.0 ATP:61101 ATPlike Pseudo DFGin 5.276 13.499 BLBplus -119.01, 147.56 55.81, 47.24 -98.35, -175.13 72.56, 101.5 63.71, -113.08 out-none out 15.017 Saltbr-none 999.0 HRD-in -101.28, -53.45 85.86, -1.89 none-out-out SNCnoo out-out ActLoopNT-out 10.061 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -56.32, -46.22 APE9-dihe-na -56.3, -35.86 APE8-dihe-out -106.06, -11.55 APE8-rot-na 74.77 APE67-dihe-in -55.12, -26.01 -77.38, -2.19 APE12-dist-out 20.65 APE11-dist-out 18.471 APE10-dist-out 23.005 APE9-dist-out 14.329 None None None EM 4.1 999.0 999.0 A 1040 314 21 0 0 0 [[539, 803]] 1.0 9bcp Homo sapiens RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6 265 260 677 678 679 681 683 567 583 587 657 659 658 660 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCPB P16066 503 841 1061.0 ATP:61101 ATPlike Pseudo DFGin 5.356 16.761 BLBtrans -138.66, -167.01 55.46, 41.07 -76.35, 89.03 193.7, 109.94 60.64, -128.0 out-none out 16.649 Saltbr-none 999.0 HRD-out -58.73, 127.47 -87.85, -41.33 none-out-out SNCnoo out-out ActLoopNT-out 12.183 ActLoopCT-out nonTYR APEdihe_aaoao APEdist_oooo APE10-dihe-na -63.64, -13.04 APE9-dihe-na -73.26, -45.78 APE8-dihe-out -94.47, 23.47 APE8-rot-na 181.32 APE67-dihe-out -126.85, -50.61 -149.46, 92.68 APE12-dist-out 22.361 APE11-dist-out 19.678 APE10-dist-out 23.708 APE9-dist-out 15.401 None None None EM 4.1 999.0 999.0 B 1040 304 21 0 0 0 [[539, 803]] 1.0 9bcp Homo sapiens RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6 265 260 677 678 679 681 683 567 583 587 657 659 658 660 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCSA P16066 503 1055 1061.0 ATP:61100 ATPlike Pseudo DFGin 7.694 15.737 None -74.51, -65.19 38.98, 36.73 -149.34, 137.28 313.08, 80.76 -109.19, -24.55 out-none out 17.336 Saltbr-none 999.0 HRD-in -67.46, -13.34 80.4, -46.04 none-out-out SNCnoo out-out ActLoopNT-out 11.453 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -59.39, -44.12 APE9-dihe-na -70.77, -47.95 APE8-dihe-out -62.03, -25.18 APE8-rot-na 74.24 APE67-dihe-in -57.49, -15.22 -74.7, -41.95 APE12-dist-out 24.021 APE11-dist-out 19.76 APE10-dist-out 23.161 APE9-dist-out 13.347 None None None EM 4.4 999.0 999.0 A 1040 515 23 0 0 0 [[539, 803]] 1.0 9bcs Homo sapiens RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6 265 260 677 678 679 681 683 567 583 587 657 659 658 660 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
RGC NPR1 ANPRA_HUMAN 9BCSB P16066 505 1055 1061.0 ATP:61100 ATPlike Pseudo None 999.0 999.0 None -84.33, 145.87 61.52, 18.75 -86.58, 62.78 999.0, 999.0 166.38, -163.08 out-none out 16.274 Saltbr-none 999.0 HRD-in -63.93, -40.93 80.49, -6.63 none-out-out SNCnoo out-out ActLoopNT-out 11.232 ActLoopCT-out nonTYR APEdihe_aaoni APEdist_oooo APE10-dihe-na -65.87, -23.07 APE9-dihe-na -84.75, -47.21 APE8-dihe-out -94.13, -13.59 APE8-rot-none 999.0 APE67-dihe-in -66.6, -21.85 -106.41, 28.83 APE12-dist-out 21.881 APE11-dist-out 20.406 APE10-dist-out 24.72 APE9-dist-out 14.261 None None None EM 4.4 999.0 999.0 B 1040 523 25 0 0 0 [[539, 803]] 1.0 9bcs Homo sapiens RGC_NPR1_HUMAN RGC 3.4e-121 410.2 6 265 260 677 678 679 681 683 567 583 587 657 659 658 660 721 705 700 699 698 697 696 695 694 613 Atrial natriuretic peptide receptor 1
STE MAP2K1 MP2K1_HUMAN 4AN3A Q02750 61 381 393.0 ATP:61383,5Y0:61384 ATPlike,Type3 Inactive DFGin 6.372 14.221 BLBplus -129.12, 178.33 68.61, 30.98 -85.55, 168.03 44.05, 86.92 -96.2, 75.38 out-out out 15.694 Saltbr-out 15.416 HRD-in -67.68, -62.51 95.67, -17.38 out-out-out SNCooo out-out ActLoopNT-out 9.23 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_onno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -140.36 APE8-dihe-in -98.61, 79.73 APE8-rot-in 326.73 APE67-dihe-in -67.76, -12.96 -73.18, -22.73 APE12-dist-out 17.69 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.352 S218E,S222E,G328A None None XRAY 2.1 0.229 0.283 A 301 277 2 0 0 2 [[68, 361]] 1.0 4an3 Homo sapiens STE_MAP2K1_HUMAN STE 1.7e-99 338.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3OS3A Q02750 62 378 393.0 ATP:1,3OS:400 ATPlike,Type3 Inactive DFGin 6.24 13.534 BLBplus -145.24, 170.05 62.26, 36.89 -93.68, 158.58 44.13, 99.29 -73.81, 106.93 out-out out 15.504 Saltbr-out 15.394 HRD-in -59.5, -62.21 84.93, 3.41 out-out-out SNCooo out-out ActLoopNT-out 9.408 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -133.7, -173.12 APE9-dihe-na 93.3, -146.81 APE8-dihe-out -139.28, -26.49 APE8-rot-out 64.05 APE67-dihe-out 179.14, 100.5 -105.07, -165.97 APE12-dist-out 14.865 APE11-dist-out 20.099 APE10-dist-out 20.846 APE9-dist-out 14.0 None None None XRAY 2.8 0.268 0.356 A 307 272 13 0 0 0 [[68, 361]] 1.0 3os3 Homo sapiens STE_MAP2K1_HUMAN STE 9.7e-99 335.8 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3DV3A Q02750 62 382 393.0 ATP:69000,MEK:69001 ATPlike,Type3 Inactive DFGin 6.248 13.603 BLBplus -133.16, -177.92 60.69, 33.15 -89.5, 161.32 45.46, 91.05 -72.95, 66.6 out-out out 15.44 Saltbr-out 15.92 HRD-in -71.02, -56.25 85.34, -10.2 out-out-out SNCooo out-out ActLoopNT-out 9.434 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 147.19 APE8-dihe-out -113.44, 8.55 APE8-rot-out 63.26 APE67-dihe-out -136.65, 142.85 -161.65, 147.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 13.723 None None None XRAY 2.3 0.184 0.221 A 322 287 34 0 0 3 [[68, 361]] 1.0 3dv3 Homo sapiens STE_MAP2K1_HUMAN STE 1.2e-97 332.2 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3PP1A Q02750 62 382 393.0 ATP:60400,IZG:60500 ATPlike,Type3 Inactive DFGin 6.243 13.533 BLBplus -142.73, -172.37 57.21, 29.66 -83.48, 161.89 45.19, 86.92 -94.1, 95.51 out-out out 15.575 Saltbr-out 15.664 HRD-in -75.88, -59.97 91.29, -12.92 out-out-out SNCooo out-out ActLoopNT-out 9.837 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -95.93, 115.09 APE9-dihe-na -80.03, 20.28 APE8-dihe-out -149.74, -167.9 APE8-rot-out 183.56 APE67-dihe-out -104.62, 136.28 16.12, 99.01 APE12-dist-out 17.803 APE11-dist-out 17.657 APE10-dist-out 19.872 APE9-dist-out 14.622 None None None XRAY 2.7 0.184 0.219 A 328 290 31 0 0 0 [[68, 361]] 1.0 3pp1 Homo sapiens STE_MAP2K1_HUMAN STE 1.3e-97 332.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3EQBA Q02750 62 382 393.0 ATP:69001,LUG:60001 ATPlike,Type3 Inactive DFGin 6.367 13.816 BLBplus -126.21, -166.87 50.54, 41.27 -103.19, 173.93 44.2, 81.11 -86.45, 70.56 out-out out 15.551 Saltbr-out 16.099 HRD-in -69.12, -59.32 92.15, -13.52 out-out-out SNCooo out-out ActLoopNT-out 9.412 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -145.13 APE9-dihe-na 160.93, -130.46 APE8-dihe-out -134.08, -9.84 APE8-rot-out 185.08 APE67-dihe-out -100.78, 136.47 -136.54, 109.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.269 APE9-dist-out 13.074 None None None XRAY 2.62 0.212 0.264 A 333 288 33 0 0 3 [[68, 361]] 1.0 3eqb Homo sapiens STE_MAP2K1_HUMAN STE 1.4e-97 332.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 1S9JA Q02750 62 382 393.0 ATP:60535,BBM:61001 ATPlike,Type3 Inactive DFGin 6.038 13.677 BLBplus -128.29, 177.35 60.26, 51.07 -106.68, 166.27 42.89, 83.29 -88.36, 87.09 out-out out 15.648 Saltbr-out 16.005 HRD-in -74.19, -52.1 76.2, -2.79 out-out-out SNCooo out-out ActLoopNT-out 9.347 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -65.48 APE9-dihe-na 93.04, 154.36 APE8-dihe-out -82.85, 11.58 APE8-rot-out 188.1 APE67-dihe-out -101.56, 129.66 -130.71, 111.45 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.148 APE9-dist-out 12.559 None None None XRAY 2.4 0.246 0.269 A 341 288 33 0 0 3 [[68, 361]] 1.0 1s9j Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3DY7A Q02750 62 364 393.0 ATP:9000,1CX:9002 ATPlike,Type3 Inactive DFGin 6.172 13.758 BLBplus -135.89, -175.79 54.31, 45.87 -100.93, 164.77 46.33, 84.08 -87.96, 76.55 out-out out 15.244 Saltbr-out 15.579 HRD-in -80.68, -50.01 86.81, -10.3 out-out-out SNCooo out-out ActLoopNT-out 9.463 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, -93.77 APE8-dihe-out -68.47, -78.94 APE8-rot-in 288.45 APE67-dihe-out -129.83, 139.32 -78.41, 146.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 14.064 None None None XRAY 2.7 0.248 0.269 A 341 260 43 0 0 3 [[68, 361]] 1.0 3dy7 Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3E8NA Q02750 62 382 393.0 ATP:60600,VRA:61001 ATPlike,Type3 Inactive DFGin 6.195 13.819 BLBplus -141.11, 177.37 57.45, 45.25 -100.77, 153.06 46.07, 82.11 -71.63, 93.26 out-out out 15.413 Saltbr-out 15.348 HRD-in -66.77, -56.92 83.67, -13.1 out-out-out SNCooo out-out ActLoopNT-out 9.432 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_onoo APE10-dihe-na 999.0, -90.03 APE9-dihe-na 88.43, 141.27 APE8-dihe-out -49.1, -69.8 APE8-rot-out 147.13 APE67-dihe-out -116.51, 140.9 -59.5, 122.62 APE12-dist-out 18.883 APE11-dist-none 999.0 APE10-dist-out 19.986 APE9-dist-out 12.831 None None None XRAY 2.5 0.219 0.252 A 341 290 31 0 0 1 [[68, 361]] 1.0 3e8n Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3VVHA Q02750 62 382 393.0 ATP:60702,4BM:60703 ATPlike,Type3 Inactive DFGin 6.389 13.656 BLBplus -137.53, 173.5 63.48, 33.18 -82.96, 158.78 37.49, 96.63 -83.81, 69.64 out-out out 15.318 Saltbr-out 14.947 HRD-in -72.04, -55.34 81.65, -10.46 out-out-out SNCooo out-out ActLoopNT-out 9.261 ActLoopCT-out nonTYR APEdihe_aanio APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -67.32 APE8-rot-in 311.04 APE67-dihe-out -121.47, 130.33 -95.91, 138.68 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.0 0.199 0.225 A 341 286 35 0 0 5 [[68, 361]] 1.0 3vvh Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3VVHB Q02750 62 382 393.0 ATP:60502,4BM:60503 ATPlike,Type3 Inactive DFGin 6.139 13.837 BLBplus -134.79, 175.55 59.54, 35.53 -87.99, 165.28 42.27, 92.99 -92.68, 76.34 out-out out 15.261 Saltbr-out 14.977 HRD-in -72.52, -58.36 78.03, -3.83 out-out-out SNCooo out-out ActLoopNT-out 9.105 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_oooo APE10-dihe-na -110.08, 147.03 APE9-dihe-na 98.19, 168.29 APE8-dihe-out -85.55, -32.58 APE8-rot-in 303.1 APE67-dihe-out -124.7, 138.59 -110.8, 145.07 APE12-dist-out 16.971 APE11-dist-out 20.559 APE10-dist-out 18.851 APE9-dist-out 12.926 None None None XRAY 2.0 0.199 0.225 B 341 289 32 0 0 0 [[68, 361]] 1.0 3vvh Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3VVHC Q02750 62 381 393.0 ATP:60502,4BM:60503 ATPlike,Type3 Inactive DFGin 6.119 13.884 BLBplus -136.04, 173.19 62.4, 33.8 -87.32, 164.72 43.72, 90.03 -81.06, 61.43 out-out out 15.395 Saltbr-out 14.906 HRD-in -71.92, -60.52 80.82, -10.24 out-out-out SNCooo out-out ActLoopNT-out 9.005 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -107.33, 145.59 APE9-dihe-na 98.43, 176.47 APE8-dihe-out -99.48, -17.12 APE8-rot-out 62.73 APE67-dihe-out -124.21, 136.5 -120.29, 144.56 APE12-dist-out 16.918 APE11-dist-out 20.623 APE10-dist-out 18.804 APE9-dist-out 12.965 None None None XRAY 2.0 0.199 0.225 C 341 282 38 0 0 0 [[68, 361]] 1.0 3vvh Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 2P55A Q02750 62 382 393.0 MRA:69000,ATP:69001 Type3,ATPlike Inactive DFGin 6.163 13.382 BLBplus -134.23, -173.95 50.87, 43.67 -95.4, 166.24 42.0, 89.87 -87.86, 76.42 out-out out 15.218 Saltbr-out 15.346 HRD-in -70.81, -55.41 89.6, -22.02 out-out-out SNCooo out-out ActLoopNT-out 9.468 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -78.03 APE9-dihe-na 94.66, -135.55 APE8-dihe-out -131.47, -8.61 APE8-rot-out 200.5 APE67-dihe-out -121.47, 132.61 -102.76, 124.64 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.174 APE9-dist-out 13.979 None None None XRAY 2.8 0.228 0.301 A 333 288 33 0 0 3 [[68, 361]] 1.0 2p55 Homo sapiens STE_MAP2K1_HUMAN STE 1.4e-97 332.1 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3V01A Q02750 62 382 393.0 3V0:60501,ATP:60502 Type3,ATPlike Inactive DFGin 6.105 13.424 BLBplus -142.06, -173.42 54.59, 34.91 -91.82, 163.8 47.01, 90.27 -88.09, 75.03 out-out out 15.564 Saltbr-out 15.778 HRD-in -62.64, -63.68 88.6, -7.02 out-out-out SNCooo out-out ActLoopNT-out 9.277 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -67.65 APE9-dihe-na 102.3, -166.23 APE8-dihe-out -116.29, 3.8 APE8-rot-out 189.24 APE67-dihe-out -108.4, 130.42 -142.07, 120.26 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 20.077 APE9-dist-out 12.838 None None None XRAY 2.705 0.189 0.24 A 341 288 33 0 0 3 [[68, 361]] 1.0 3v01 Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K1 MP2K1_HUMAN 3V04A Q02750 62 382 393.0 V04:60501,ATP:60502 Type3,ATPlike Inactive DFGin 6.202 13.466 BLBplus -139.99, -177.53 54.26, 36.29 -92.6, 163.3 43.17, 90.4 -92.7, 75.2 out-out out 15.613 Saltbr-out 16.049 HRD-in -56.82, -58.2 81.63, -6.31 out-out-out SNCooo out-out ActLoopNT-out 9.11 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnoo APE10-dihe-na 999.0, -43.92 APE9-dihe-na 143.86, 160.52 APE8-dihe-out -85.24, -10.44 APE8-rot-out 182.43 APE67-dihe-out -103.47, 130.39 -134.15, 117.69 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 19.808 APE9-dist-out 12.649 None None None XRAY 2.7 0.213 0.243 A 341 288 33 0 0 3 [[68, 361]] 1.0 3v04 Homo sapiens STE_MAP2K1_HUMAN STE 1.5e-97 331.9 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
STE MAP2K2 MP2K2_HUMAN 1S9IA P36507 60 393 400.0 ATP:535,5EA:1001 ATPlike,Type3 Inactive DFGin 6.287 13.269 BLBplus -139.34, -174.92 56.51, 21.27 -79.15, 150.55 47.45, 91.25 -79.77, 85.37 out-out out 15.529 Saltbr-out 17.297 HRD-out -62.14, 153.21 -129.12, 19.13 out-out-out SNCooo out-out ActLoopNT-out 8.898 ActLoopCT-out nonTYR APEdihe_aaoio APEdist_nnoo APE10-dihe-na 999.0, 134.1 APE9-dihe-na -103.89, 62.93 APE8-dihe-out -65.91, -35.32 APE8-rot-in 354.81 APE67-dihe-out -93.63, 150.37 -174.34, 119.99 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 21.618 APE9-dist-out 12.732 None None None XRAY 3.2 0.294 0.364 A 354 303 31 0 0 4 [[72, 369]] 1.0 1s9i Homo sapiens STE_MAP2K2_HUMAN STE 1.5e-97 331.9 1 257 257 211 212 213 215 217 101 118 122 191 193 192 194 249 237 232 231 230 229 228 227 226 148 Dual specificity mitogen-activated protein kinase kinase 2
STE MAP2K2 MP2K2_HUMAN 1S9IB P36507 59 389 400.0 ATP:537,5EA:1002 ATPlike,Type3 Inactive DFGin 6.282 13.638 BLBplus -139.5, 161.8 56.55, 60.44 -106.38, 150.17 37.7, 87.0 -78.89, 77.21 out-out out 15.534 Saltbr-out 15.004 HRD-out -92.42, 79.21 -68.62, 14.72 out-out-out SNCooo out-out ActLoopNT-out 9.517 ActLoopCT-out nonTYR APEdihe_aanoo APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, -33.93 APE8-rot-out 15.08 APE67-dihe-out -144.19, 132.88 -117.04, 157.31 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 3.2 0.294 0.364 B 354 291 40 0 0 6 [[72, 369]] 1.0 1s9i Homo sapiens STE_MAP2K2_HUMAN STE 1.5e-97 331.9 1 257 257 211 212 213 215 217 101 118 122 191 193 192 194 249 237 232 231 230 229 228 227 226 148 Dual specificity mitogen-activated protein kinase kinase 2
STE PAK1 PAK1_HUMAN 3Q53A Q13153 250 541 545.0 ATP:1 ATPlike Inactive DFGin 6.546 15.968 BLAminus -131.41, -173.51 59.18, 73.62 -91.64, 12.88 288.75, 75.16 -60.67, -19.44 out-none out 10.159 Saltbr-none 999.0 HRD-in -69.79, -48.58 76.19, -3.19 none-in-in SNCnii in-in ActLoopNT-in 2.837 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -132.58, -17.38 APE9-dihe-na -66.64, 179.65 APE8-dihe-in -103.57, 123.03 APE8-rot-in 305.32 APE67-dihe-in -60.91, -26.26 -42.88, -52.15 APE12-dist-in 8.284 APE11-dist-in 10.463 APE10-dist-in 4.727 APE9-dist-in 3.438 K299R,L516I TPO423 TPO423 XRAY 2.09 0.207 0.223 A 306 292 0 0 0 0 [[270, 521]] 1.0 3q53 Homo sapiens STE_PAK1_HUMAN STE 2.5e-94 321.4 1 257 257 406 407 408 410 412 299 315 319 386 388 387 389 446 434 429 428 427 426 425 424 423 345 Serine/threonine-protein kinase PAK 1
STE PAK4 PAK4_HUMAN 4XBRA O96013 177 589 591.0 ATP:60601 ATPlike Inactive DFGin 5.852 14.061 ABAminus -142.04, -22.23 -111.42, 72.59 -86.56, 10.51 310.81, 99.4 -46.84, -40.66 in-in in 7.009 Saltbr-in 3.158 HRD-in -84.11, -33.57 58.48, -1.88 in-in-in SNCiii in-in ActLoopNT-in 2.974 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -133.96, 132.02 APE9-dihe-na 150.85, -176.82 APE8-dihe-in -102.34, 122.5 APE8-rot-in 312.14 APE67-dihe-in -59.91, -25.15 -35.82, -60.88 APE12-dist-in 9.335 APE11-dist-in 11.927 APE10-dist-in 6.05 APE9-dist-in 3.396 None SEP474 SEP474 XRAY 2.94 0.191 0.23 A 366 293 0 0 0 0 [[321, 572]] 1.0 4xbr Homo sapiens STE_PAK4_HUMAN STE 3.7e-88 301.2 5 257 253 457 458 459 461 463 350 366 370 437 439 438 440 497 485 480 479 478 477 476 475 474 396 Serine/threonine-protein kinase PAK 4
STE STK24 STK24_HUMAN 3A7HA Q9Y6E0 18 310 443.0 ATP:60400 ATPlike Inactive DFGin 6.274 16.06 BLAminus -135.27, 174.99 54.48, 64.86 -70.71, -58.08 287.78, 76.92 45.88, -44.99 in-out in 9.722 Saltbr-out 4.493 HRD-in -66.74, -51.36 77.62, -11.47 out-in-in SNCoii in-in ActLoopNT-in 2.797 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.61, 151.93 APE9-dihe-na 118.1, -167.87 APE8-dihe-in -108.64, 120.02 APE8-rot-in 324.07 APE67-dihe-in -58.13, -27.9 -30.96, -56.98 APE12-dist-in 8.269 APE11-dist-in 11.137 APE10-dist-in 5.543 APE9-dist-in 3.566 None TPO190 TPO190 XRAY 1.96 0.21 0.252 A 303 290 0 0 0 0 [[36, 286]] 1.0 3a7h Homo sapiens STE_STK24_HUMAN STE 3.6e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STK24 STK24_HUMAN 3A7HB Q9Y6E0 17 310 443.0 ATP:60400 ATPlike Inactive DFGin 6.685 16.86 BLAminus -138.1, 177.76 56.48, 71.8 -87.83, 21.17 281.85, 78.43 -54.77, -28.24 out-out out 10.376 Saltbr-out 4.639 HRD-in -73.68, -49.41 75.79, -7.51 out-in-in SNCoii in-in ActLoopNT-in 2.816 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -142.6, 158.04 APE9-dihe-na 117.1, -164.51 APE8-dihe-in -112.27, 119.11 APE8-rot-in 308.97 APE67-dihe-in -56.45, -30.21 -34.32, -55.35 APE12-dist-in 8.215 APE11-dist-in 11.012 APE10-dist-in 5.261 APE9-dist-in 3.401 None TPO190 TPO190 XRAY 1.96 0.21 0.252 B 303 291 0 0 0 0 [[36, 286]] 1.0 3a7h Homo sapiens STE_STK24_HUMAN STE 3.6e-100 340.5 1 257 257 173 174 175 177 179 65 82 86 153 155 154 156 213 201 196 195 194 193 192 191 190 112 Serine/threonine-protein kinase 24
STE STRADA STRAA_HUMAN 3GNIB Q7RTN6 60 431 431.0 ATP:60001 ATPlike Pseudo DFGin 5.228 13.358 BLAminus -109.39, -155.43 74.77, 29.57 -67.06, -15.75 299.34, 10.06 -54.98, -34.79 in-none in 9.9 Saltbr-none 999.0 HRD-in -71.88, -63.47 83.33, 4.11 none-in-out SNCnio in-out ActLoopNT-in 2.866 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_iooo APE10-dihe-na -73.5, 108.36 APE9-dihe-na 128.9, -33.16 APE8-dihe-out -82.37, -8.26 APE8-rot-na 193.56 APE67-dihe-in -56.7, -25.37 -48.29, -50.45 APE12-dist-in 8.527 APE11-dist-out 7.098 APE10-dist-out 12.899 APE9-dist-out 9.897 None None None XRAY 2.35 0.207 0.254 B 389 290 56 0 0 0 [[69, 379]] 1.0 3gni Homo sapiens STE_STRADA_HUMAN STE 4.7e-87 297.8 1 257 257 212 213 214 216 218 100 118 122 192 194 193 195 261 247 242 241 240 239 238 237 236 148 STE20-related kinase adapter protein alpha
TKL ILK ILK_HUMAN 9D5IA Q13418 182 452 452.0 ATP:502 ATPlike Pseudo DFGinter 8.261 6.842 None -85.91, 104.5 -70.94, -26.25 -67.8, 1.23 999.0, 999.0 -109.51, 3.6 out-out out 13.611 Saltbr-out 13.777 HRD-out 63.45, 28.98 -91.0, 110.88 out-out-out SNCooo out-out ActLoopNT-out 6.365 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioo APE10-dihe-na -132.95, 115.89 APE9-dihe-na -99.41, -2.16 APE8-dihe-in -138.47, 54.8 APE8-rot-none 999.0 APE67-dihe-in -62.49, -23.03 -64.85, -19.12 APE12-dist-out 14.705 APE11-dist-in 13.99 APE10-dist-out 13.138 APE9-dist-out 13.265 R225A,C346S,C422S None None XRAY 1.5 0.23 0.267 A 271 271 0 0 0 0 [[192, 448]] 1.0 9d5i Homo sapiens TKL_ILK_HUMAN TKL 2.8e-62 216.7 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 3KMWA Q13418 185 452 452.0 ATP:502 ATPlike Pseudo DFGinter 8.3 6.975 None -80.97, 99.65 -67.11, -24.75 -72.37, 0.55 999.0, 999.0 -103.25, 4.58 out-out out 13.496 Saltbr-out 14.041 HRD-out 59.64, 26.4 -91.04, 116.86 out-out-out SNCooo out-out ActLoopNT-out 6.367 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oooo APE10-dihe-na -122.08, 118.72 APE9-dihe-na -100.74, -5.98 APE8-dihe-in -137.53, 58.2 APE8-rot-none 999.0 APE67-dihe-in -63.57, -23.06 -67.47, -16.05 APE12-dist-out 14.71 APE11-dist-out 14.04 APE10-dist-out 13.057 APE9-dist-out 13.027 C346S,C422S None None XRAY 2.0 0.199 0.203 A 271 268 0 0 0 0 [[192, 448]] 1.0 3kmw Homo sapiens TKL_ILK_HUMAN TKL 1.5e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL ILK ILK_HUMAN 3REPA Q13418 185 452 452.0 ATP:502 ATPlike Pseudo DFGinter 8.264 6.894 None -81.35, 101.61 -70.12, -25.38 -69.18, -5.31 999.0, 999.0 -98.03, -0.84 out-out out 13.359 Saltbr-out 14.12 HRD-out 62.24, 23.62 -86.21, 112.03 out-out-out SNCooo out-out ActLoopNT-out 6.454 ActLoopCT-out nonTYR APEdihe_aaini APEdist_oioo APE10-dihe-na -114.84, 122.73 APE9-dihe-na -97.69, -5.36 APE8-dihe-in -136.02, 58.25 APE8-rot-none 999.0 APE67-dihe-in -57.73, -27.19 -63.83, -23.69 APE12-dist-out 14.498 APE11-dist-in 13.981 APE10-dist-out 12.94 APE9-dist-out 13.101 C346S,C422S None None XRAY 1.8 0.206 0.238 A 271 268 0 0 0 0 [[192, 448]] 1.0 3rep Homo sapiens TKL_ILK_HUMAN TKL 1.5e-62 217.5 3 267 265 336 337 338 340 342 220 238 242 316 318 317 319 374 359 354 353 352 351 350 349 348 270 Scaffold protein ILK
TKL KSR2 KSR2_HUMAN 2Y4IB Q6VAB6 653 931 950.0 ATP:1932 ATPlike Pseudo DFGin 6.039 13.357 BLBplus -163.04, 167.92 56.95, 32.67 -75.07, 155.41 46.1, 92.34 53.05, 51.5 out-none out 15.58 Saltbr-none 999.0 HRD-in -80.25, -38.53 67.56, -67.09 none-out-out SNCnoo out-out ActLoopNT-out 10.43 ActLoopCT-out nonTYR APEdihe_aaoai APEdist_oooo APE10-dihe-na -56.45, -137.53 APE9-dihe-na -67.8, 7.84 APE8-dihe-out -54.46, -37.41 APE8-rot-na 170.99 APE67-dihe-in -92.05, 13.42 -60.84, -28.22 APE12-dist-out 17.417 APE11-dist-out 14.576 APE10-dist-out 17.158 APE9-dist-out 12.262 None None None XRAY 3.46 0.233 0.293 B 319 265 14 0 0 10 [[665, 930]] 1.0 2y4i Homo sapiens TKL_KSR2_HUMAN TKL 1.1e-70 244.1 2 267 266 802 803 804 806 808 692 710 714 783 785 784 786 856 835 830 829 828 827 826 825 824 740 Kinase suppressor of Ras 2
TKL LRRK2 LRRK2_HUMAN 8FO9A Q5S007 1329 2527 2527.0 ATP:2602 ATPlike Active DFGin 6.273 13.41 BLAminus -138.23, -175.7 59.6, 64.71 -84.85, 53.99 305.84, 101.34 -78.49, -28.55 in-in in 7.88 Saltbr-in 2.735 HRD-in -107.83, -47.31 66.25, 1.81 in-in-in SNCiii in-in ActLoopNT-in 3.031 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -138.21, 156.34 APE9-dihe-na 139.24, 152.96 APE8-dihe-in -67.96, 127.7 APE8-rot-in 305.42 APE67-dihe-inflip 98.56, -16.69 -58.5, 136.92 APE12-dist-in 9.183 APE11-dist-in 11.487 APE10-dist-in 6.004 APE9-dist-in 3.816 None None None EM 3.48 999.0 999.0 A 2527 1173 0 0 0 0 [[1875, 2134]] 1.0 8fo9 Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO9C Q5S007 1329 2527 2527.0 ATP:2602 ATPlike Active DFGin 6.275 13.405 BLAminus -138.14, -175.77 59.5, 64.85 -84.95, 53.97 305.9, 101.31 -78.52, -28.52 in-in in 7.883 Saltbr-in 2.729 HRD-in -108.59, -47.2 66.33, 1.76 in-in-in SNCiii in-in ActLoopNT-in 3.008 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -137.94, 156.21 APE9-dihe-na 139.37, 152.96 APE8-dihe-in -67.92, 127.71 APE8-rot-in 305.58 APE67-dihe-inflip 98.46, -16.81 -58.61, 136.94 APE12-dist-in 9.177 APE11-dist-in 11.503 APE10-dist-in 6.012 APE9-dist-in 3.804 None None None EM 3.48 999.0 999.0 C 2527 1173 0 0 0 0 [[1875, 2134]] 1.0 8fo9 Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LHTA Q5S007 558 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 9.844 8.295 None -64.84, 122.35 -98.75, -0.04 -71.37, -28.28 172.84, 65.91 -59.04, -42.88 out-out out 11.156 Saltbr-out 7.841 HRD-in -69.75, -40.92 72.72, -9.61 out-out-out SNCooo out-out ActLoopNT-out 9.784 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -82.21, -17.19 APE9-dihe-na 90.26, 154.46 APE8-dihe-in -57.7, 141.99 APE8-rot-in 318.57 APE67-dihe-in -63.97, -43.36 -55.36, -52.39 APE12-dist-in 9.673 APE11-dist-in 10.145 APE10-dist-out 14.096 APE9-dist-in 4.097 None None None EM 3.5 999.0 999.0 A 2527 1795 3 0 0 3 [[1875, 2134]] 1.0 7lht Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LHTB Q5S007 558 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 9.844 8.295 None -64.86, 122.35 -98.72, -0.04 -71.37, -28.3 172.84, 65.9 -59.09, -42.88 out-out out 11.156 Saltbr-out 7.841 HRD-in -69.81, -40.92 72.73, -9.55 out-out-out SNCooo out-out ActLoopNT-out 9.783 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -82.22, -17.15 APE9-dihe-na 90.23, 154.47 APE8-dihe-in -57.69, 142.03 APE8-rot-in 318.55 APE67-dihe-in -64.0, -43.36 -55.37, -52.4 APE12-dist-in 9.672 APE11-dist-in 10.145 APE10-dist-out 14.096 APE9-dist-in 4.097 None None None EM 3.5 999.0 999.0 B 2527 1795 3 0 0 3 [[1875, 2134]] 1.0 7lht Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LHWA Q5S007 540 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 10.349 8.277 None -70.88, 117.76 -93.02, 2.5 -63.92, -24.19 170.47, 59.39 -60.34, -43.84 out-out out 10.98 Saltbr-out 7.258 HRD-in -74.65, -33.87 72.74, -12.12 out-out-out SNCooo out-out ActLoopNT-out 9.631 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -74.42, -8.25 APE9-dihe-na 81.17, 153.49 APE8-dihe-in -58.6, 142.93 APE8-rot-in 304.43 APE67-dihe-in -63.74, -43.48 -51.59, -53.96 APE12-dist-in 10.236 APE11-dist-in 9.457 APE10-dist-out 13.872 APE9-dist-in 4.335 None None None EM 3.7 999.0 999.0 A 2527 1813 3 0 0 3 [[1875, 2134]] 1.0 7lhw Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LI4A Q5S007 558 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 9.844 8.294 None -64.77, 122.33 -98.76, -0.03 -71.41, -28.21 172.83, 65.95 -59.02, -42.88 out-out out 11.157 Saltbr-out 7.842 HRD-in -69.78, -40.92 72.72, -9.67 out-out-out SNCooo out-out ActLoopNT-out 9.784 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -82.19, -17.19 APE9-dihe-na 90.26, 154.48 APE8-dihe-in -57.73, 142.01 APE8-rot-in 318.58 APE67-dihe-in -63.98, -43.36 -55.36, -52.38 APE12-dist-in 9.673 APE11-dist-in 10.145 APE10-dist-out 14.096 APE9-dist-in 4.096 None None None EM 3.1 999.0 999.0 A 2527 1795 3 0 0 3 [[1875, 2134]] 1.0 7li4 Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO2E Q5S007 12 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 10.549 8.183 None -77.97, 115.31 -99.8, 16.1 -71.24, -24.34 179.0, 61.54 -64.41, -41.78 out-out out 11.347 Saltbr-out 7.851 HRD-in -73.2, -35.27 72.81, -10.29 out-out-out SNCooo out-out ActLoopNT-out 9.492 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -67.29, -18.03 APE9-dihe-na 75.0, 160.57 APE8-dihe-in -64.56, 133.01 APE8-rot-in 300.63 APE67-dihe-in -63.84, -35.14 -59.88, -35.03 APE12-dist-in 9.119 APE11-dist-in 10.588 APE10-dist-out 14.447 APE9-dist-in 4.382 None None None EM 4.13 999.0 999.0 E 2527 2275 4 0 0 3 [[1875, 2134]] 1.0 8fo2 Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO8C Q5S007 12 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 10.404 8.367 None -77.76, 115.2 -99.79, 16.57 -70.68, -24.12 178.89, 61.58 -64.22, -41.72 out-out out 11.341 Saltbr-out 7.744 HRD-in -73.07, -35.29 72.76, -10.32 out-out-out SNCooo out-out ActLoopNT-out 9.471 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -67.5, -18.26 APE9-dihe-na 74.89, 160.43 APE8-dihe-in -64.77, 133.4 APE8-rot-in 300.66 APE67-dihe-in -63.6, -35.05 -59.67, -34.64 APE12-dist-in 9.071 APE11-dist-in 10.522 APE10-dist-out 14.411 APE9-dist-in 4.449 None None None EM 3.88 999.0 999.0 C 2527 2270 4 0 0 3 [[1875, 2134]] 1.0 8fo8 Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO8E Q5S007 12 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 10.415 8.349 None -77.68, 115.13 -99.83, 16.55 -70.64, -24.07 178.91, 61.52 -64.18, -41.73 out-out out 11.321 Saltbr-out 7.73 HRD-in -73.0, -35.27 72.87, -10.42 out-out-out SNCooo out-out ActLoopNT-out 9.47 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -67.4, -18.35 APE9-dihe-na 74.93, 160.44 APE8-dihe-in -64.61, 133.34 APE8-rot-in 300.72 APE67-dihe-in -63.56, -35.05 -59.56, -34.8 APE12-dist-in 9.056 APE11-dist-in 10.526 APE10-dist-out 14.406 APE9-dist-in 4.434 None None None EM 3.88 999.0 999.0 E 2527 2270 4 0 0 3 [[1875, 2134]] 1.0 8fo8 Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO9F Q5S007 12 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 9.348 8.575 None -68.36, 152.72 -137.53, 18.95 -81.54, -22.77 187.88, 51.61 -70.19, -36.74 out-out out 11.238 Saltbr-out 8.326 HRD-in -76.93, -42.26 72.06, -11.17 out-out-out SNCooo out-out ActLoopNT-out 9.106 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -70.82, -18.07 APE9-dihe-na 87.94, 175.98 APE8-dihe-in -63.48, 135.16 APE8-rot-in 300.23 APE67-dihe-in -66.37, -45.6 -58.88, -37.04 APE12-dist-in 9.718 APE11-dist-in 10.578 APE10-dist-out 14.122 APE9-dist-in 4.473 None None None EM 3.48 999.0 999.0 F 2527 2289 3 0 0 3 [[1875, 2134]] 1.0 8fo9 Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 7LI3A Q5S007 558 2527 2527.0 ATP:2602 ATPlike Inactive DFGinter 9.583 8.403 None -64.7, 121.5 -105.97, 8.82 -69.04, -26.41 175.66, 65.26 -63.25, -46.61 out-out out 11.401 Saltbr-out 8.121 HRD-in -76.04, -34.97 73.14, -12.04 out-out-out SNCooo out-out ActLoopNT-out 9.664 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -85.32, -9.76 APE9-dihe-na 87.27, 160.92 APE8-dihe-in -56.79, 143.13 APE8-rot-in 300.33 APE67-dihe-in -63.35, -39.62 -56.92, -55.07 APE12-dist-in 10.386 APE11-dist-in 10.363 APE10-dist-out 14.006 APE9-dist-in 3.652 None None None EM 3.8 999.0 999.0 A 2527 1795 3 0 0 3 [[1875, 2134]] 1.0 7li3 Homo sapiens TKL_LRRK2_HUMAN TKL 3.9e-56 197.0 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TKL LRRK2 LRRK2_HUMAN 8FO9E Q5S007 12 2527 2527.0 ATP:2602 ATPlike Inactive DFGout 11.374 7.913 None -68.54, 152.71 -137.53, 21.65 -90.85, -9.64 146.2, 91.59 -82.02, -36.47 out-out out 11.16 Saltbr-out 8.209 HRD-in -76.97, -42.35 72.15, -11.11 out-out-out SNCooo out-out ActLoopNT-out 9.123 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_iioi APE10-dihe-na -70.77, -18.05 APE9-dihe-na 87.91, 175.95 APE8-dihe-in -63.49, 135.16 APE8-rot-in 300.24 APE67-dihe-in -66.44, -45.65 -58.78, -37.14 APE12-dist-in 9.651 APE11-dist-in 10.552 APE10-dist-out 14.083 APE9-dist-in 4.472 None None None EM 3.48 999.0 999.0 E 2527 2287 3 0 0 3 [[1875, 2134]] 1.0 8fo9 Homo sapiens TKL_LRRK2_HUMAN TKL 3.8e-57 200.3 5 266 262 2016 2017 2018 2020 2022 1906 1920 1924 1991 1993 1992 1994 2055 2042 2037 2036 2035 2034 2033 2032 2031 1948 Leucine-rich repeat serine/threonine-protein kinase 2
TYR EGFR EGFR_HUMAN 8PO4B P00533 700 1014 1210.0 ATP:1101 ATPlike Inactive DFGin 5.624 16.394 BLBtrans -121.3, 175.63 63.19, 26.9 -63.92, 138.21 163.94, 68.04 83.38, -10.03 out-out out 13.6 Saltbr-out 13.029 HRD-in -73.28, -55.5 80.32, -14.85 out-out-out SNCooo out-out ActLoopNT-out 6.486 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, 119.23 APE8-dihe-in -81.98, 63.66 APE8-rot-na 32.98 APE67-dihe-in -71.84, -8.05 -50.66, -40.3 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 8.255 V948R None None XRAY 1.621 0.211 0.243 B 328 295 20 0 0 13 [[712, 970]] 1.0 8po4 Homo sapiens TYR_EGFR_HUMAN TYR 7.9e-88 300.2 3 259 257 854 855 856 858 860 745 762 766 834 836 835 837 896 884 879 878 877 876 875 874 873 791 Epidermal growth factor receptor
TYR INSR INSR_HUMAN 3BU5A P06213 1014 1310 1382.0 ATP:60300 ATPlike Active DFGin 6.659 13.934 BLAminus -128.64, -166.6 44.54, 89.54 -102.81, 23.91 295.82, 99.34 -57.5, -34.18 in-in in 8.261 Saltbr-in 3.13 HRD-in -68.86, -51.91 77.02, -10.33 in-in-in SNCiii in-in ActLoopNT-in 2.844 ActLoopCT-in TYR APEdihe_iiiai APEdist_aaai APE10-dihe-in -82.0, 102.51 APE9-dihe-in -127.85, 151.44 APE8-dihe-in -79.76, 69.1 APE8-rot-na 32.47 APE67-dihe-in -66.77, -8.03 -57.27, -41.89 APE12-dist-na 15.937 APE11-dist-na 11.724 APE10-dist-na 11.3 APE9-dist-in 7.401 C1008S PTR1185,PTR1189,PTR1190 PTR1185,PTR1189,PTR1190 XRAY 2.1 0.196 0.239 A 306 294 3 0 0 0 [[1023, 1292]] 1.0 3bu5 Homo sapiens TYR_INSR_HUMAN TYR 1.3e-96 328.8 1 260 260 1176 1177 1178 1180 1182 1057 1074 1078 1156 1158 1157 1159 1218 1206 1201 1200 1199 1198 1197 1196 1195 1104 Insulin receptor
TYR JAK2-1 JAK2_HUMAN 5I4NA O60674 537 809 1132.0 ATP:61000 ATPlike Pseudo DFGin 5.668 13.386 None -68.19, 172.29 -64.41, 158.19 -73.31, -26.63 342.84, 34.8 77.82, -169.16 out-na out 11.405 Saltbr-na 999.0 HRD-in -78.6, -60.98 86.96, 3.87 na-out-out SNCaoo out-out ActLoopNT-out 8.681 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -68.12, -41.49 APE9-dihe-out -58.18, -29.35 APE8-dihe-out -88.11, 6.74 APE8-rot-na 290.83 APE67-dihe-out -103.83, 26.01 -65.06, 135.53 APE12-dist-na 10.037 APE11-dist-na 11.7 APE10-dist-na 16.278 APE9-dist-out 12.372 E596A,V617F,W659A,W777A,F794H None None XRAY 1.54 0.174 0.193 A 290 273 0 0 0 0 [[545, 807], [849, 1125]] 2.0 5i4n Homo sapiens TYR_JAK2-1_HUMAN TYR 7.1e-64 221.5 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 4FVRA O60674 536 809 1132.0 ATP:901 ATPlike Pseudo DFGin 5.766 13.376 None -77.86, -178.54 -72.61, 163.95 -75.06, -27.39 334.11, 39.64 77.27, -166.65 out-na out 11.782 Saltbr-na 999.0 HRD-in -74.66, -57.27 90.8, -3.55 na-out-out SNCaoo out-out ActLoopNT-out 8.537 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -64.48, -33.68 APE9-dihe-out -63.8, -34.8 APE8-dihe-out -85.1, 11.44 APE8-rot-na 293.02 APE67-dihe-out -101.64, 24.24 -66.8, 135.55 APE12-dist-na 9.675 APE11-dist-na 11.473 APE10-dist-na 16.037 APE9-dist-out 12.028 V617F,W777A,F794H None None XRAY 2.0 0.183 0.229 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4fvr Homo sapiens TYR_JAK2-1_HUMAN TYR 6.4e-64 221.7 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 4FVQA O60674 536 809 1132.0 ATP:901 ATPlike Pseudo DFGin 6.411 13.531 None -82.38, -178.3 -71.29, 157.18 -64.23, -31.16 342.38, 32.32 77.45, -167.94 out-na out 10.357 Saltbr-na 999.0 HRD-in -81.79, -59.57 93.66, -10.87 na-out-out SNCaoo out-out ActLoopNT-out 9.094 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.14, -35.28 APE9-dihe-out -67.39, -22.98 APE8-dihe-out -92.26, 6.93 APE8-rot-na 290.03 APE67-dihe-out -106.47, 27.81 -64.4, 133.6 APE12-dist-na 9.912 APE11-dist-na 11.487 APE10-dist-na 16.075 APE9-dist-out 12.378 W659A,W777A,F794H None None XRAY 1.75 0.176 0.199 A 289 274 0 0 0 0 [[545, 807], [849, 1125]] 2.0 4fvq Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C08A O60674 537 810 1132.0 ATP:901 ATPlike Pseudo DFGin 6.598 13.736 None -72.21, 176.69 -66.6, 164.57 -72.8, -15.2 349.18, 27.02 73.34, -163.25 in-na in 9.4 Saltbr-na 999.0 HRD-in -80.72, -74.63 111.24, -16.83 na-out-out SNCaoo out-out ActLoopNT-out 9.474 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -55.86, -37.52 APE9-dihe-out -72.05, -28.92 APE8-dihe-out -74.69, -10.21 APE8-rot-na 283.12 APE67-dihe-out -93.42, 18.23 -54.81, 139.34 APE12-dist-na 9.92 APE11-dist-na 11.859 APE10-dist-na 16.352 APE9-dist-out 12.53 W659A,W777A,F794H None None XRAY 2.2 0.267 0.259 A 289 270 4 0 0 0 [[545, 807], [849, 1125]] 2.0 8c08 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR JAK2-1 JAK2_HUMAN 8C08B O60674 536 810 1132.0 ATP:901 ATPlike Pseudo DFGin 5.646 13.539 None -63.04, -178.12 -72.48, 164.14 -59.19, -39.37 337.51, 34.58 89.58, -173.09 out-na out 12.178 Saltbr-na 999.0 HRD-in -76.08, -63.96 89.49, 0.26 na-out-out SNCaoo out-out ActLoopNT-out 8.73 ActLoopCT-out TYR APEdihe_oooao APEdist_aaao APE10-dihe-out -65.09, -36.29 APE9-dihe-out -67.21, -14.45 APE8-dihe-out -97.09, 0.9 APE8-rot-na 279.42 APE67-dihe-out -95.31, 21.21 -63.75, 135.54 APE12-dist-na 10.848 APE11-dist-na 11.837 APE10-dist-na 16.6 APE9-dist-out 12.658 W659A,W777A,F794H None None XRAY 2.2 0.267 0.259 B 289 269 6 0 0 0 [[545, 807], [849, 1125]] 2.0 8c08 Homo sapiens TYR_JAK2-1_HUMAN TYR 1.9e-64 223.4 2 260 259 698 699 700 702 704 581 597 601 670 672 671 673 735 722 717 716 715 714 713 712 711 627 Tyrosine-protein kinase JAK2
TYR MET MET_HUMAN 3DKCA P08581 1051 1360 1390.0 ATP:60001 ATPlike Inactive DFGin 5.693 13.103 BLBplus -128.11, 162.74 67.51, 17.44 -61.67, 130.17 44.2, 92.69 80.08, -22.94 out-out out 14.083 Saltbr-out 12.836 HRD-in -71.17, -57.45 82.5, -22.81 out-out-out SNCooo out-out ActLoopNT-out 7.739 ActLoopCT-out TYR APEdihe_oiiai APEdist_aaao APE10-dihe-out -83.24, -9.16 APE9-dihe-in -104.14, 150.23 APE8-dihe-in -75.82, 62.17 APE8-rot-na 30.64 APE67-dihe-in -64.7, -18.65 -61.74, -26.11 APE12-dist-na 18.53 APE11-dist-na 20.199 APE10-dist-na 15.662 APE9-dist-out 9.072 Y1194F,Y1234F,Y1235D None None XRAY 1.52 0.189 0.218 A 317 310 0 0 0 0 [[1078, 1339]] 1.0 3dkc Homo sapiens TYR_MET_HUMAN TYR 8.6e-90 306.9 2 260 259 1221 1222 1223 1225 1227 1110 1127 1131 1201 1203 1202 1204 1265 1253 1248 1247 1246 1245 1244 1243 1242 1158 Hepatocyte growth factor receptor
TYR PTK2 FAK1_HUMAN 2IJMA Q05397 414 688 1052.0 ATP:690 ATPlike Inactive DFGin 5.335 15.255 None -130.4, -10.41 -96.6, 92.35 -115.09, 154.36 308.92, 97.78 84.66, -9.12 in-in in 7.602 Saltbr-in 2.544 HRD-in -77.84, -47.69 90.07, -21.21 in-none-out SNCino none-out ActLoopNT-none 999.0 ActLoopCT-out TYR APEdihe_nniai APEdist_aaao APE10-dihe-none 999.0, 999.0 APE9-dihe-none 999.0, -43.55 APE8-dihe-in -70.98, 54.52 APE8-rot-na 26.91 APE67-dihe-in -71.31, -14.5 -49.75, -42.31 APE12-dist-na 999.0 APE11-dist-na 999.0 APE10-dist-na 999.0 APE9-dist-out 9.531 None None None XRAY 2.187 0.211 0.271 A 281 260 15 0 0 15 [[422, 678]] 1.0 2ijm Homo sapiens TYR_PTK2_HUMAN TYR 3.5e-93 317.6 1 260 260 563 564 565 567 569 454 471 475 543 545 544 546 604 592 587 586 585 584 583 582 581 500 Focal adhesion kinase 1
TKL RIPK A0A811MC32_9POAL 8HOAA A0A811MC32 90 387 441.0 ATP:60701,HX2:60702 ATPlike,Allosteric Inactive DFGin 6.061 12.606 BLBplus -114.97, 161.69 65.77, 20.85 -71.65, 141.67 50.94, 88.04 74.58, 5.91 out-none out 13.156 Saltbr-none 999.0 HRD-out -77.34, 149.41 -82.88, -37.27 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 19.65 APE8-dihe-out -73.34, -23.03 APE8-rot-out 81.86 APE67-dihe-out 95.0, 11.7 -84.03, -15.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.206 None None None XRAY 1.676 0.188 0.213 A 326 271 27 0 0 16 [[105, 385]] 1.0 8hoa Miscanthus lutarioriparius TKL_RIPK_9POAL TKL 1.9e-59 207.4 4 266 263 253 254 255 257 259 141 157 161 233 235 234 236 295 283 278 277 276 275 274 273 272 187 non-specific serine/threonine protein kinase
AGC PRKACA KAPCA_MOUSE 1ATPE P05132 16 351 351.0 ATP:60355 ATPlike Inactive DFGin 6.23 14.588 BLAminus -105.27, -165.6 48.73, 87.06 -105.12, 16.76 267.19, 75.22 -52.19, -32.07 in-out in 9.161 Saltbr-out 3.634 HRD-in -88.29, -43.64 51.81, 19.16 out-in-in SNCoii in-in ActLoopNT-in 2.808 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.21, 146.28 APE9-dihe-na 146.09, -156.15 APE8-dihe-in -133.3, 119.84 APE8-rot-in 299.98 APE67-dihe-in -65.71, -15.81 -24.26, -60.76 APE12-dist-in 8.353 APE11-dist-in 11.41 APE10-dist-in 5.706 APE9-dist-in 3.99 None TPO198,SEP339 TPO198,SEP339 XRAY 2.2 0.177 999.0 E 350 336 0 0 0 0 [[44, 298]] 1.0 1atp Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3FJQE P05132 16 351 351.0 ATP:60403 ATPlike Active DFGin 5.671 14.459 BLAminus -119.42, 178.78 63.28, 80.04 -91.81, 23.31 270.73, 57.82 -56.09, -30.86 in-in in 9.149 Saltbr-in 2.834 HRD-in -91.33, -52.39 67.42, 13.87 in-in-in SNCiii in-in ActLoopNT-in 2.906 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.19, 160.44 APE9-dihe-na 133.42, -155.21 APE8-dihe-in -125.75, 136.86 APE8-rot-in 304.0 APE67-dihe-in -61.0, -22.29 -48.87, -49.39 APE12-dist-in 8.086 APE11-dist-in 11.408 APE10-dist-in 5.838 APE9-dist-in 3.518 None TPO198,SEP339 TPO198,SEP339 XRAY 1.6 0.179 0.205 E 350 336 0 0 0 0 [[44, 298]] 1.0 3fjq Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DH1A P05132 16 351 351.0 ATP:60402 ATPlike Active DFGin 6.234 14.38 BLAminus -130.7, 167.11 69.97, 89.08 -103.01, 26.92 273.93, 57.95 -52.62, -33.38 in-in in 8.931 Saltbr-in 3.01 HRD-in -75.69, -51.31 65.95, 10.85 in-in-in SNCiii in-in ActLoopNT-in 2.887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.97, 163.54 APE9-dihe-na 128.87, -151.55 APE8-dihe-in -123.52, 135.53 APE8-rot-in 304.09 APE67-dihe-in -55.69, -26.94 -40.23, -59.36 APE12-dist-in 8.169 APE11-dist-in 11.557 APE10-dist-in 5.95 APE9-dist-in 3.545 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.0 0.199 0.234 A 350 336 0 0 0 0 [[44, 298]] 1.0 4dh1 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DH3A P05132 16 351 351.0 ATP:60403 ATPlike Active DFGin 5.984 14.379 BLAminus -125.47, 176.75 61.82, 79.89 -92.16, 24.39 276.69, 54.39 -43.39, -47.09 in-in in 9.021 Saltbr-in 2.723 HRD-in -82.56, -48.22 66.04, -2.33 in-in-in SNCiii in-in ActLoopNT-in 2.931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.47, 165.55 APE9-dihe-na 126.96, -149.27 APE8-dihe-in -125.58, 130.88 APE8-rot-in 307.35 APE67-dihe-in -57.88, -25.54 -37.95, -56.15 APE12-dist-in 8.225 APE11-dist-in 11.592 APE10-dist-in 6.104 APE9-dist-in 3.74 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.2 0.203 0.233 A 350 336 0 0 0 0 [[44, 298]] 1.0 4dh3 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DINA P05132 10 351 351.0 ATP:60400 ATPlike Inactive DFGin 5.792 13.144 BLAminus -127.84, -176.29 51.22, 102.02 -109.69, 31.05 287.96, 58.2 -47.08, -31.2 in-in in 8.518 Saltbr-in 3.498 HRD-out -64.69, -78.02 71.93, 51.46 in-in-out SNCiio in-out ActLoopNT-in 2.994 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -152.73, 153.23 APE9-dihe-na 130.84, -154.91 APE8-dihe-in -121.15, 137.05 APE8-rot-out 34.65 APE67-dihe-in -46.77, -45.03 -45.98, -63.1 APE12-dist-in 7.972 APE11-dist-in 10.588 APE10-dist-in 4.997 APE9-dist-in 3.53 None TPO198,SEP339 TPO198,SEP339 XRAY 3.7 0.211 0.293 A 350 342 0 0 0 0 [[44, 298]] 1.0 4din Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4X6RA P05132 2 351 351.0 ATP:60402 ATPlike Active DFGin 6.133 14.232 BLAminus -118.92, 178.27 64.18, 79.91 -89.21, 11.01 274.1, 55.74 -49.19, -34.95 in-in in 8.804 Saltbr-in 2.729 HRD-in -85.13, -60.38 77.67, -7.87 in-in-in SNCiii in-in ActLoopNT-in 2.718 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.34, 156.01 APE9-dihe-na 147.33, -149.7 APE8-dihe-in -130.56, 138.51 APE8-rot-in 291.09 APE67-dihe-in -61.2, -24.8 -52.44, -47.95 APE12-dist-in 8.281 APE11-dist-in 11.246 APE10-dist-in 5.836 APE9-dist-in 3.663 K8C SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.4 0.186 0.234 A 350 350 0 0 0 0 [[44, 298]] 1.0 4x6r Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3X2UA P05132 13 351 351.0 ATP:60501 ATPlike Active DFGin 6.127 14.507 BLAminus -122.24, 178.58 59.36, 87.7 -101.54, 25.28 272.61, 50.83 -59.45, -24.26 in-in in 9.272 Saltbr-in 2.788 HRD-in -89.58, -50.62 64.84, 17.58 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.25, 158.3 APE9-dihe-na 134.88, -147.54 APE8-dihe-in -130.4, 131.58 APE8-rot-in 300.12 APE67-dihe-in -61.26, -14.4 -40.08, -55.22 APE12-dist-in 7.912 APE11-dist-in 11.137 APE10-dist-in 5.686 APE9-dist-in 3.427 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.4 0.202 0.239 A 357 339 0 0 0 0 [[44, 298]] 1.0 3x2u Mus musculus AGC_PRKACA_MOUSE AGC 1.6e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3X2VA P05132 18 351 351.0 ATP:60403 ATPlike Active DFGin 5.517 14.152 BLAminus -116.69, -175.94 62.92, 80.3 -91.77, 26.26 271.42, 55.44 -51.78, -39.79 in-in in 8.755 Saltbr-in 2.654 HRD-in -92.08, -50.84 67.69, 17.07 in-in-in SNCiii in-in ActLoopNT-in 2.881 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.85, 164.45 APE9-dihe-na 134.14, -152.5 APE8-dihe-in -130.83, 133.42 APE8-rot-in 299.77 APE67-dihe-in -58.82, -21.18 -48.96, -48.11 APE12-dist-in 7.998 APE11-dist-in 11.346 APE10-dist-in 5.796 APE9-dist-in 3.415 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.77 0.185 0.23 A 357 334 0 0 0 0 [[44, 298]] 1.0 3x2v Mus musculus AGC_PRKACA_MOUSE AGC 1.6e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3X2WA P05132 13 351 351.0 ATP:60403 ATPlike Active DFGin 5.66 14.39 BLAminus -121.01, -177.68 63.51, 77.56 -90.4, 24.79 270.4, 59.29 -61.83, -28.06 in-in in 8.822 Saltbr-in 2.632 HRD-in -81.34, -52.24 70.22, 11.48 in-in-in SNCiii in-in ActLoopNT-in 2.906 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.19, 162.39 APE9-dihe-na 132.4, -151.44 APE8-dihe-in -129.91, 133.08 APE8-rot-in 300.2 APE67-dihe-in -60.45, -20.83 -45.18, -51.38 APE12-dist-in 8.001 APE11-dist-in 11.44 APE10-dist-in 5.911 APE9-dist-in 3.45 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.7 0.165 0.198 A 357 339 0 0 0 0 [[44, 298]] 1.0 3x2w Mus musculus AGC_PRKACA_MOUSE AGC 1.6e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4XW5A P05132 15 351 351.0 ATP:60403 ATPlike Active DFGin 5.971 14.222 BLAminus -131.24, 177.82 59.66, 87.19 -93.08, 25.08 282.37, 63.43 -53.77, -29.24 in-in in 9.213 Saltbr-in 2.673 HRD-in -90.87, -48.94 63.52, 13.92 in-in-in SNCiii in-in ActLoopNT-in 2.812 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.24, 155.03 APE9-dihe-na 137.47, -160.98 APE8-dihe-in -110.31, 133.6 APE8-rot-in 304.05 APE67-dihe-in -58.14, -25.36 -48.87, -50.12 APE12-dist-in 8.026 APE11-dist-in 11.601 APE10-dist-in 6.1 APE9-dist-in 3.922 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.95 0.185 0.252 A 356 337 0 0 0 0 [[44, 298]] 1.0 4xw5 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3QAME P05132 2 351 351.0 ATP:60351 ATPlike Active DFGin 5.559 14.19 BLAminus -125.2, -173.2 57.82, 79.24 -94.32, 24.42 273.28, 56.46 -52.36, -33.22 in-in in 8.98 Saltbr-in 2.804 HRD-in -80.54, -55.75 67.52, 12.49 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.45, 157.56 APE9-dihe-na 134.84, -152.56 APE8-dihe-in -129.9, 127.65 APE8-rot-in 298.13 APE67-dihe-in -57.31, -20.14 -26.19, -66.74 APE12-dist-in 8.094 APE11-dist-in 11.277 APE10-dist-in 5.806 APE9-dist-in 3.475 E209A TPO198,SEP339 TPO198,SEP339 XRAY 1.92 0.195 0.228 E 350 350 0 0 0 0 [[44, 298]] 1.0 3qam Mus musculus AGC_PRKACA_MOUSE AGC 2.2e-93 318.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3QALE P05132 2 351 351.0 ATP:60351 ATPlike Active DFGin 5.64 14.401 BLAminus -123.21, -177.09 59.31, 80.89 -94.71, 25.93 269.1, 56.43 -54.28, -32.32 in-in in 9.05 Saltbr-in 2.658 HRD-in -84.64, -51.07 65.64, 14.74 in-in-in SNCiii in-in ActLoopNT-in 2.962 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.61, 159.73 APE9-dihe-na 131.58, -155.18 APE8-dihe-in -126.66, 132.34 APE8-rot-in 301.51 APE67-dihe-in -57.77, -23.32 -31.31, -63.36 APE12-dist-in 8.062 APE11-dist-in 11.309 APE10-dist-in 5.744 APE9-dist-in 3.531 R281A TPO198,SEP339 TPO198,SEP339 XRAY 1.7 0.176 0.194 E 350 341 0 0 0 0 [[44, 298]] 1.0 3qal Mus musculus AGC_PRKACA_MOUSE AGC 4.5e-93 317.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 1RDQE P05132 2 351 351.0 ADP:60599,ATP:60600 ATPlike,ATPlike Active DFGin 5.707 14.515 BLAminus -117.27, 178.71 64.74, 81.19 -90.07, 21.82 270.96, 52.48 -58.25, -31.62 in-in in 9.091 Saltbr-in 2.719 HRD-in -91.16, -53.36 73.19, 12.39 in-in-in SNCiii in-in ActLoopNT-in 2.936 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.91, 159.57 APE9-dihe-na 132.64, -151.85 APE8-dihe-in -127.7, 133.09 APE8-rot-in 298.45 APE67-dihe-in -59.33, -27.24 -47.42, -47.34 APE12-dist-in 8.116 APE11-dist-in 11.414 APE10-dist-in 5.831 APE9-dist-in 3.521 Y205A TPO198,SEP339 TPO198,SEP339 XRAY 1.26 0.132 0.162 E 350 342 0 0 0 0 [[44, 298]] 1.0 1rdq Mus musculus AGC_PRKACA_MOUSE AGC 1.1e-92 315.9 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CAMK DAPK2 DAPK2_MOUSE 2YAAA Q8VDF3 12 311 370.0 ATP:61302 ATPlike Active DFGin 6.531 14.282 BLAminus -119.44, -173.75 61.63, 82.55 -100.44, 26.82 279.23, 73.82 -61.71, -30.38 in-in in 9.437 Saltbr-in 2.945 HRD-in -69.91, -51.35 70.12, 4.4 in-in-in SNCiii in-in ActLoopNT-in 2.83 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.66, 179.02 APE9-dihe-na 88.17, 165.82 APE8-dihe-in -83.03, 124.75 APE8-rot-in 307.34 APE67-dihe-in -54.24, -28.42 -45.93, -43.89 APE12-dist-in 8.679 APE11-dist-in 11.592 APE10-dist-in 6.391 APE9-dist-in 4.926 None None None XRAY 2.3 0.219 0.271 A 361 300 0 0 0 0 [[23, 285]] 1.0 2yaa Mus musculus CAMK_DAPK2_MOUSE CAMK 1.1e-93 319.4 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_MOUSE 2YAAB Q8VDF3 13 311 370.0 ATP:61302 ATPlike Inactive DFGin 6.584 14.289 BLAminus -119.54, -178.65 66.98, 88.67 -108.71, 24.01 280.41, 69.43 -62.37, -28.55 out-out out 10.171 Saltbr-out 5.377 HRD-in -72.87, -55.45 75.11, 6.49 out-in-in SNCoii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -174.59, 179.36 APE9-dihe-na 81.98, 166.79 APE8-dihe-in -83.03, 125.4 APE8-rot-in 303.87 APE67-dihe-in -54.18, -26.93 -45.18, -48.55 APE12-dist-in 8.764 APE11-dist-in 11.596 APE10-dist-in 6.43 APE9-dist-in 4.828 None None None XRAY 2.3 0.219 0.271 B 361 299 0 0 0 0 [[23, 285]] 1.0 2yaa Mus musculus CAMK_DAPK2_MOUSE CAMK 1.1e-93 319.4 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CMGC MAPK14 MK14_MOUSE 7Z9TBBB P47811 4 353 360.0 87B:401,ATP:402 Type3,Allosteric Inactive DFGin 5.829 15.244 BLBminus -103.34, -178.81 25.47, 89.69 -68.87, -161.65 315.54, 109.9 -76.7, 116.65 out-out out 10.342 Saltbr-out 4.179 HRD-in -67.82, -70.27 93.09, -17.91 out-out-out SNCooo out-out ActLoopNT-out 7.706 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -124.01, -67.71 APE9-dihe-na -98.04, -13.3 APE8-dihe-out -67.58, -39.12 APE8-rot-in 311.0 APE67-dihe-in -63.55, -21.3 -74.81, -8.77 APE12-dist-out 14.596 APE11-dist-out 16.356 APE10-dist-out 19.352 APE9-dist-out 12.538 None None None XRAY 2.6 0.202 0.254 BBB 359 350 0 0 0 0 [[24, 308]] 1.0 7z9t Mus musculus CMGC_MAPK14_MOUSE CMGC 5e-85 291.4 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
STE STK39 STK39_MOUSE 5D9HA Q9Z1W9 65 363 556.0 ATP:501 ATPlike Inactive DFGin 5.686 16.437 BLBtrans -110.31, 163.68 60.83, 61.1 -112.91, 152.73 160.61, 82.83 89.94, -129.86 out-out out 13.682 Saltbr-out 14.175 HRD-in -79.34, -55.51 78.38, -0.69 out-out-out SNCooo out-out ActLoopNT-out 7.753 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 89.3 APE9-dihe-na 145.31, -162.33 APE8-dihe-in -128.36, 135.86 APE8-rot-out 189.19 APE67-dihe-in -54.38, -21.28 -96.66, 16.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 27.054 APE9-dist-out 28.547 None None None XRAY 3.1 0.24 0.269 A 348 290 9 0 0 7 [[75, 349]] 1.0 5d9h Mus musculus STE_STK39_MOUSE STE 1.3e-90 309.2 1 257 257 221 222 223 225 227 104 121 125 201 203 202 204 267 254 249 248 247 246 245 244 243 151 STE20/SPS1-related proline-alanine-rich protein kinase
STE STK39 STK39_MOUSE 5D9HB Q9Z1W9 65 364 556.0 ATP:501 ATPlike Inactive DFGin 5.686 16.557 BLBtrans -110.27, 163.88 60.61, 61.2 -112.96, 152.81 160.68, 82.77 89.89, -127.48 out-out out 13.712 Saltbr-out 13.101 HRD-in -78.11, -50.69 74.23, -12.16 out-out-out SNCooo out-out ActLoopNT-out 7.913 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 140.15 APE8-dihe-in -87.12, 142.28 APE8-rot-out 185.38 APE67-dihe-in -78.59, -19.5 -91.99, 27.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 28.707 None None None XRAY 3.1 0.24 0.269 B 348 293 7 0 0 7 [[75, 349]] 1.0 5d9h Mus musculus STE_STK39_MOUSE STE 1.3e-90 309.2 1 257 257 221 222 223 225 227 104 121 125 201 203 202 204 267 254 249 248 247 246 245 244 243 151 STE20/SPS1-related proline-alanine-rich protein kinase
TKL RIPK4 RIPK4_MOUSE 5WNIA Q9ERK0 9 288 786.0 ATP:403 ATPlike Inactive DFGin 5.031 14.764 BLAminus -137.21, -171.18 63.31, 81.36 -101.4, 15.3 283.28, 78.59 -51.45, -36.22 in-in in 8.646 Saltbr-in 2.482 HRD-in -76.93, -54.51 67.9, 5.7 in-in-out SNCiio in-out ActLoopNT-in 3.204 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 127.03 APE9-dihe-na -72.21, -45.63 APE8-dihe-out -54.13, -30.5 APE8-rot-out 51.09 APE67-dihe-in -56.9, -38.97 -54.07, -35.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.458 APE9-dist-out 11.387 D143N None None XRAY 2.65 0.204 0.248 A 342 263 17 0 0 13 [[19, 285]] 1.0 5wni Mus musculus TKL_RIPK4_MOUSE TKL 1.4e-74 257.0 4 266 263 160 161 162 164 166 51 69 73 140 142 141 143 205 191 186 185 184 183 182 181 180 97 Receptor-interacting serine/threonine-protein kinase 4
CAMK PHKG1 PHKG1_RABIT 2PHKA P00518 15 291 387.0 ATP:60381 ATPlike Active DFGin 6.355 14.931 BLAminus -137.29, -164.32 48.12, 82.5 -104.58, 35.29 286.95, 71.57 -66.18, -30.51 in-in in 9.223 Saltbr-in 2.867 HRD-in -75.14, -51.03 75.46, 17.9 in-in-in SNCiii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.02, 157.52 APE9-dihe-na 142.39, -153.7 APE8-dihe-in -119.73, 129.29 APE8-rot-in 312.14 APE67-dihe-in -75.97, -3.06 -46.22, -51.97 APE12-dist-in 9.188 APE11-dist-in 12.037 APE10-dist-in 6.565 APE9-dist-in 4.187 None None None XRAY 2.6 0.253 0.3 A 277 277 0 0 0 0 [[20, 288]] 1.0 2phk Oryctolagus cuniculus CAMK_PHKG1_RABIT CAMK 3e-86 294.8 1 256 256 167 168 169 171 173 49 74 78 147 149 148 150 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK PHKG1 PHKG1_RABIT 1QL6A P00518 12 292 387.0 ATP:60301 ATPlike Active DFGin 6.367 14.614 BLAminus -136.63, -170.42 53.21, 74.77 -97.04, 26.39 287.52, 75.09 -70.06, -14.72 in-in in 9.205 Saltbr-in 3.1 HRD-in -59.97, -49.78 67.92, 7.3 in-in-in SNCiii in-in ActLoopNT-in 2.896 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.76, 155.97 APE9-dihe-na 109.55, 169.96 APE8-dihe-in -76.43, 127.92 APE8-rot-in 308.32 APE67-dihe-in -67.24, -23.63 -51.61, -34.62 APE12-dist-in 9.259 APE11-dist-in 11.445 APE10-dist-in 6.11 APE9-dist-in 4.369 E183S None None XRAY 2.4 0.24 0.33 A 298 281 0 0 0 0 [[20, 288]] 1.0 1ql6 Oryctolagus cuniculus CAMK_PHKG1_RABIT CAMK 5.1e-86 294.1 1 256 256 167 168 169 171 173 49 74 78 147 149 148 150 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK PHKG1 PHKG1_RABIT 1PHKA P00518 16 292 387.0 ATP:60381 ATPlike Active DFGin 6.147 14.336 BLAminus -126.89, -173.45 56.12, 79.25 -99.09, 29.57 290.92, 76.23 -67.63, -19.58 in-in in 8.993 Saltbr-in 2.825 HRD-in -77.33, -46.36 68.03, 5.86 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.41, 147.14 APE9-dihe-na 116.4, 168.87 APE8-dihe-in -72.55, 120.48 APE8-rot-in 295.05 APE67-dihe-in -62.26, -27.58 -41.92, -42.38 APE12-dist-in 8.836 APE11-dist-in 11.43 APE10-dist-in 6.157 APE9-dist-in 4.492 None None None XRAY 2.2 0.21 0.288 A 298 277 0 0 0 0 [[20, 288]] 1.0 1phk Oryctolagus cuniculus CAMK_PHKG1_RABIT CAMK 4e-86 294.4 1 256 256 167 168 169 171 173 49 74 78 147 149 148 150 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
STE MAP2K1 MP2K1_RABIT 2Y4IC P29678 37 381 393.0 ATP:1382 ATPlike Inactive DFGin 6.197 13.756 BLBplus -151.54, -176.33 53.75, 29.39 -91.07, 130.43 56.39, 97.48 -61.44, 113.3 out-out out 16.132 Saltbr-out 15.794 HRD-in -53.6, -47.94 74.29, -22.1 out-out-out SNCooo out-out ActLoopNT-out 9.9 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -108.6, -60.21 APE9-dihe-na 86.78, -165.04 APE8-dihe-out -116.15, -0.77 APE8-rot-out 172.84 APE67-dihe-out -107.13, 167.3 -126.53, 122.47 APE12-dist-out 16.259 APE11-dist-out 19.161 APE10-dist-out 21.278 APE9-dist-out 14.867 None None None XRAY 3.46 0.233 0.293 C 395 313 32 0 0 0 [[68, 361]] 1.0 2y4i Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.5e-97 331.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
OTHER FLS2 FLS2_ORYSJ 8JUPA Q0JA29 861 1176 1183.0 ATP:60401 ATPlike Inactive DFGin 6.159 14.181 BLAminus -129.46, 178.87 65.25, 87.62 -100.45, 24.31 288.53, 78.58 -69.31, -13.11 in-in in 7.758 Saltbr-in 2.635 HRD-in -73.88, -45.26 75.34, -0.8 in-in-out SNCiio in-out ActLoopNT-in 2.758 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -97.88, 176.26 APE9-dihe-na 47.04, -123.5 APE8-dihe-out -91.29, -3.22 APE8-rot-out 60.74 APE67-dihe-in -61.44, -18.49 -67.89, -32.09 APE12-dist-out 23.433 APE11-dist-out 18.481 APE10-dist-out 19.369 APE9-dist-out 12.347 None None MSE903,MSE959,MSE1037,MSE1066,MSE1073,MSE1090,MSE1134,MSE1166,MSE1176 XRAY 1.98 0.202 0.221 A 327 286 30 0 0 16 [[874, 1175]] 1.0 8jup Oryza sativa OTHER_FLS2_ORYSJ TKL 3.2e-44 157.5 4 265 262 1030 1031 1032 1034 1036 908 926 930 1010 1012 1011 1013 1081 1069 1064 1063 1062 1061 1060 1059 1058 957 LRR receptor-like serine/threonine-protein kinase FLS2
CMGC CK1 Q8IIR9_PLAF7 5XVUA Q8IIR9 12 332 335.0 ATP:403 ATPlike Inactive DFGin 7.321 16.711 BLAminus -110.04, -170.26 56.43, 69.12 -91.86, 16.9 294.29, 86.98 -66.48, -34.8 in-in in 9.452 Saltbr-in 2.802 HRD-in -73.92, -41.02 61.9, 9.67 in-in-out SNCiio in-out ActLoopNT-in 2.966 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.27, 163.04 APE9-dihe-na 66.36, 159.74 APE8-dihe-in -64.44, 138.76 APE8-rot-out 161.92 APE67-dihe-in -63.63, -26.0 -45.45, -45.73 APE12-dist-in 12.799 APE11-dist-in 10.78 APE10-dist-in 6.004 APE9-dist-in 3.652 None None None XRAY 3.0 0.174 0.216 A 332 321 0 0 0 0 [[43, 328]] 1.0 5xvu Plasmodium falciparum CMGC_CK1_PLAF7 CMGC 2.9e-67 232.9 1 301 301 178 179 180 182 184 72 85 89 157 159 158 160 218 205 200 199 198 197 196 195 194 118 non-specific serine/threonine protein kinase
CMGC CK1 Q8IIR9_PLAF7 5XVUB Q8IIR9 12 332 335.0 ATP:404 ATPlike Inactive DFGin 7.401 16.674 BLAminus -109.75, -170.19 56.85, 69.23 -92.76, 17.97 295.03, 87.19 -67.17, -35.33 in-in in 9.301 Saltbr-in 2.793 HRD-in -71.07, -41.36 62.96, 8.73 in-in-out SNCiio in-out ActLoopNT-in 2.864 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -122.62, -85.86 APE9-dihe-na -52.99, 173.24 APE8-dihe-in -65.9, 138.47 APE8-rot-out 161.08 APE67-dihe-in -63.67, -25.37 -44.18, -46.51 APE12-dist-in 12.744 APE11-dist-in 10.615 APE10-dist-in 5.941 APE9-dist-in 3.597 None None None XRAY 3.0 0.174 0.216 B 332 321 0 0 0 0 [[43, 328]] 1.0 5xvu Plasmodium falciparum CMGC_CK1_PLAF7 CMGC 2.9e-67 232.9 1 301 301 178 179 180 182 184 72 85 89 157 159 158 160 218 205 200 199 198 197 196 195 194 118 non-specific serine/threonine protein kinase
CMGC CK1 Q8IIR9_PLAF7 5XVUC Q8IIR9 12 332 335.0 ATP:405 ATPlike Inactive DFGin 7.492 16.742 BLAminus -109.76, -170.14 57.17, 68.62 -92.1, 18.51 294.14, 87.94 -67.81, -35.21 in-in in 9.456 Saltbr-in 2.808 HRD-in -70.49, -40.6 62.72, 9.24 in-in-out SNCiio in-out ActLoopNT-in 2.942 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -116.02, -79.39 APE9-dihe-na -60.1, 172.38 APE8-dihe-in -65.34, 140.21 APE8-rot-out 160.23 APE67-dihe-in -64.3, -24.41 -46.46, -45.68 APE12-dist-in 12.741 APE11-dist-in 10.642 APE10-dist-in 5.845 APE9-dist-in 3.632 None None None XRAY 3.0 0.174 0.216 C 332 321 0 0 0 0 [[43, 328]] 1.0 5xvu Plasmodium falciparum CMGC_CK1_PLAF7 CMGC 2.9e-67 232.9 1 301 301 178 179 180 182 184 72 85 89 157 159 158 160 218 205 200 199 198 197 196 195 194 118 non-specific serine/threonine protein kinase
CMGC MAPK1 MK01_RAT 4GT3A P63086 9 356 358.0 ATP:402 ATPlike Inactive DFGin 6.703 16.144 BLAminus -134.54, -176.44 66.94, 76.71 -104.84, 22.9 282.81, 76.31 -55.64, -34.0 in-none in 9.817 Saltbr-none 999.0 HRD-in -69.89, -50.79 79.79, -14.59 none-in-out SNCnio in-out ActLoopNT-in 2.776 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -105.46, -44.03 APE9-dihe-na -70.04, 169.29 APE8-dihe-in -70.71, 123.51 APE8-rot-in 309.48 APE67-dihe-in -61.98, -17.54 -56.41, -47.97 APE12-dist-out 14.289 APE11-dist-in 11.003 APE10-dist-in 6.74 APE9-dist-in 4.422 None None CME159 XRAY 1.68 0.168 0.2 A 364 348 0 0 0 0 [[23, 311]] 1.0 4gt3 Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.4e-85 293.1 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 1GOLA P63086 2 358 358.0 ATP:581 ATPlike Inactive DFGin 6.84 16.509 BLAminus -138.32, 175.35 71.89, 79.82 -106.15, 29.68 287.28, 71.38 -70.4, -19.75 out-none out 10.408 Saltbr-none 999.0 HRD-in -68.54, -52.86 75.92, 1.19 none-in-out SNCnio in-out ActLoopNT-in 2.899 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -103.2, -24.36 APE9-dihe-na -62.06, 164.48 APE8-dihe-in -61.17, 119.13 APE8-rot-in 302.33 APE67-dihe-in -53.15, -25.45 -41.46, -58.53 APE12-dist-out 14.339 APE11-dist-in 11.207 APE10-dist-in 7.401 APE9-dist-in 4.282 K52R None None XRAY 2.8 999.0 999.0 A 364 357 0 0 0 0 [[23, 311]] 1.0 1gol Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.4e-84 289.8 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
STE TAOK2 TAOK2_RAT 1U5RA Q9JLS3 12 320 1235.0 ATP:411 ATPlike Active DFGin 6.99 14.24 BLAminus -128.27, -174.18 56.24, 80.49 -99.99, 21.83 293.09, 83.93 -60.11, -26.41 in-in in 8.687 Saltbr-in 2.887 HRD-in -75.95, -53.43 76.2, -2.14 in-in-in SNCiii in-in ActLoopNT-in 2.767 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.19, 153.0 APE9-dihe-na 135.08, -166.49 APE8-dihe-in -116.65, 119.51 APE8-rot-in 301.53 APE67-dihe-in -56.87, -24.9 -27.41, -63.55 APE12-dist-in 8.446 APE11-dist-in 11.391 APE10-dist-in 5.507 APE9-dist-in 3.279 None SEP181 SEP181 XRAY 2.1 0.211 0.244 A 348 309 0 0 0 0 [[28, 281]] 1.0 1u5r Rattus norvegicus STE_TAOK2_RAT STE 1.4e-89 305.8 2 257 256 168 169 170 172 174 57 76 80 148 150 149 151 207 192 187 186 185 184 183 182 181 106 Serine/threonine-protein kinase TAO2
STE TAOK2 TAOK2_RAT 1U5RB Q9JLS3 12 320 1235.0 ATP:412 ATPlike Active DFGin 6.763 13.896 BLAminus -129.03, -178.62 56.08, 82.23 -96.99, 22.88 295.53, 83.61 -63.46, -23.11 in-in in 8.772 Saltbr-in 2.623 HRD-in -71.62, -50.86 71.95, 2.83 in-in-in SNCiii in-in ActLoopNT-in 2.776 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.4, 155.39 APE9-dihe-na 130.83, -165.29 APE8-dihe-in -116.7, 116.24 APE8-rot-in 302.47 APE67-dihe-in -61.68, -22.51 -24.84, -62.59 APE12-dist-in 8.905 APE11-dist-in 11.02 APE10-dist-in 5.282 APE9-dist-in 3.304 None SEP181 SEP181 XRAY 2.1 0.211 0.244 B 348 309 0 0 0 0 [[28, 281]] 1.0 1u5r Rattus norvegicus STE_TAOK2_RAT STE 1.4e-89 305.8 2 257 256 168 169 170 172 174 57 76 80 148 150 149 151 207 192 187 186 185 184 183 182 181 106 Serine/threonine-protein kinase TAO2
CMGC CKA1 CSK21_YEAST 4FI1A P15790 1 371 372.0 ATP:403 ATPlike Inactive None 23.938 16.237 None -116.2, -173.62 60.19, 79.18 -100.6, 15.4 291.83, 86.61 -72.61, -17.46 out-na out 37.858 Saltbr-na 999.0 HRD-in -72.28, -48.07 67.04, 8.76 na-in-out SNCaio in-out ActLoopNT-in 2.926 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.66, 175.92 APE9-dihe-na 60.75, -165.68 APE8-dihe-in -116.66, 152.71 APE8-rot-out 187.49 APE67-dihe-in -64.93, -21.65 -39.27, -55.57 APE12-dist-in 12.741 APE11-dist-in 10.923 APE10-dist-in 6.072 APE9-dist-in 3.419 None None None XRAY 2.09 0.206 0.243 A 374 371 0 0 0 0 [[100, 363]] 1.0 4fi1 Saccharomyces cerevisiae CMGC_CKA1_YEAST CMGC 0.0001 199.7 1 55 321 213 214 215 217 219 69 114 118 192 194 193 195 253 240 235 234 233 232 231 230 229 153 Casein kinase II subunit alpha
CMGC CKA1 CSK21_YEAST 4MWHA P15790 1 371 372.0 ATP:401 ATPlike Inactive None 23.978 16.218 None -116.51, -173.69 61.16, 78.03 -99.81, 14.04 291.24, 86.36 -72.33, -17.88 out-na out 37.853 Saltbr-na 999.0 HRD-in -70.43, -48.46 67.2, 9.69 na-in-out SNCaio in-out ActLoopNT-in 2.96 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -135.3, 175.12 APE9-dihe-na 58.95, -171.53 APE8-dihe-in -112.48, 153.51 APE8-rot-out 184.1 APE67-dihe-in -66.06, -21.26 -39.33, -54.63 APE12-dist-in 12.731 APE11-dist-in 10.923 APE10-dist-in 6.071 APE9-dist-in 3.479 None None None XRAY 2.09 0.199 0.241 A 374 371 0 0 0 0 [[100, 363]] 1.0 4mwh Saccharomyces cerevisiae CMGC_CKA1_YEAST CMGC 0.0001 199.7 1 55 321 213 214 215 217 219 69 114 118 192 194 193 195 253 240 235 234 233 232 231 230 229 153 Casein kinase II subunit alpha
CMGC SKY1 SKY1_YEAST 1Q97A Q03656 144 737 742.0 ATP:60485 ATPlike Active DFGin 5.605 12.648 BLAminus -113.61, -176.06 45.65, 81.54 -92.49, 25.33 294.84, 21.0 -61.4, -14.56 in-in in 8.92 Saltbr-in 2.91 HRD-in -73.18, -42.39 69.86, -2.96 in-in-in SNCiii in-in ActLoopNT-in 2.985 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.18, 168.88 APE9-dihe-na 68.54, 141.02 APE8-dihe-in -74.6, 131.99 APE8-rot-in 300.34 APE67-dihe-in -58.79, -28.16 -13.13, -73.4 APE12-dist-in 12.586 APE11-dist-in 10.498 APE10-dist-in 7.631 APE9-dist-in 3.163 None None None XRAY 2.3 0.215 0.264 A 373 351 11 0 0 0 [[158, 706]] 1.0 1q97 Saccharomyces cerevisiae CMGC_SKY1_YEAST CMGC 8.8e-100 339.7 1 301 301 549 550 551 553 555 187 202 206 291 293 292 294 586 574 569 568 567 566 565 564 563 247 Serine/threonine-protein kinase SKY1
OTHER GCN2-2 GCN2_YEAST 1ZYDA P15442 594 996 1659.0 ATP:60303 ATPlike Inactive DFGin 6.41 14.106 BLBminus -140.51, -168.68 57.3, 45.16 -50.27, 137.38 287.66, 72.18 -82.02, 105.81 out-out out 12.801 Saltbr-out 11.502 HRD-in -64.16, -46.0 70.86, 0.79 out-out-out SNCooo out-out ActLoopNT-out 8.833 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 87.46 APE9-dihe-na 82.34, -63.68 APE8-dihe-out -63.29, -19.6 APE8-rot-out 172.58 APE67-dihe-in -77.43, -0.66 -78.79, -26.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.861 APE9-dist-out 12.094 None None None XRAY 2.75 0.208 0.27 A 303 268 32 0 0 26 [[292, 527], [599, 981]] 2.0 1zyd Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 7.9e-45 164.1 2 254 253 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
OTHER GCN2-2 GCN2_YEAST 1ZYDB P15442 594 983 1659.0 ATP:60304 ATPlike Inactive DFGin 6.558 14.184 BLBminus -148.24, -169.36 49.61, 62.39 -64.34, 151.67 288.08, 61.76 -84.72, 102.57 out-out out 12.647 Saltbr-out 11.162 HRD-in -64.07, -43.6 67.43, 4.77 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 127.88 APE9-dihe-na -94.37, -36.47 APE8-dihe-out -54.75, -25.46 APE8-rot-in 302.91 APE67-dihe-in -57.91, -12.21 -57.71, -47.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.788 APE9-dist-out 11.857 None None None XRAY 2.75 0.208 0.27 B 303 251 36 0 0 27 [[292, 527], [599, 981]] 2.0 1zyd Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 7.9e-45 164.1 2 254 253 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
TKL NCGRLOCUS634 A0ACD6BAX3_9POAL 8HO6A A0ACD6BAX3 7 305 312.0 ATP:60401 ATPlike Active DFGin 6.377 15.619 BLAminus -139.79, 171.9 63.28, 66.12 -93.24, 62.65 279.35, 60.61 -82.08, -30.35 in-in in 8.644 Saltbr-in 2.728 HRD-in -60.88, -41.53 70.8, -58.95 in-in-in SNCiii in-in ActLoopNT-in 2.72 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.65, 146.26 APE9-dihe-na 148.14, -156.83 APE8-dihe-in -124.83, 132.59 APE8-rot-in 314.24 APE67-dihe-inflip 93.19, -27.63 -56.53, 137.58 APE12-dist-in 9.991 APE11-dist-in 11.771 APE10-dist-in 6.261 APE9-dist-in 5.587 None TPO184,SEP187,TPO188 TPO184,SEP187,TPO188 XRAY 2.1 0.206 0.234 A 326 281 18 0 0 2 [[22, 302]] 1.0 8ho6 Saccharum hybrid cultivar TKL_NCGRLOCUS634_9POAL TKL 3.7e-60 209.7 4 266 263 170 171 172 174 176 58 74 78 150 152 151 153 212 200 195 194 193 192 191 190 189 104 ScRIPK kinase protein
CK1 CKI1 CKI1_SCHPO 1CSNA P40233 6 298 446.0 ATP:299 ATPlike Active DFGin 6.422 13.79 BLAminus -124.8, 177.22 63.85, 88.12 -109.85, 36.77 298.25, 97.14 -71.61, -21.33 in-in in 8.04 Saltbr-in 3.086 HRD-in -68.74, -48.02 63.6, 9.84 in-in-in SNCiii in-in ActLoopNT-in 2.815 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -97.61, -90.82 APE9-dihe-na -65.25, -165.09 APE8-dihe-in -55.42, 111.92 APE8-rot-in 313.89 APE67-dihe-in -55.02, -31.3 -55.98, -42.83 APE12-dist-in 12.741 APE11-dist-in 13.007 APE10-dist-in 7.16 APE9-dist-in 4.794 None None None XRAY 2.0 0.207 999.0 A 298 293 0 0 0 0 [[12, 280]] 1.0 1csn Schizosaccharomyces pombe CK1_CKI1_SCHPO CK1 8e-95 323.1 1 261 261 153 154 155 157 159 41 55 59 128 130 129 131 200 188 183 182 181 180 179 178 177 86 Casein kinase I homolog 1
OTHER None A0ACD6BAW3_SERSF 5HNVA A0ACD6BAW3 11 298 302.0 ATP:401 ATPlike Inactive DFGin 5.795 14.621 ABAminus -94.42, -26.67 -170.11, 138.36 -108.4, 3.69 302.8, 148.02 68.44, 20.57 in-out in 9.647 Saltbr-out 4.566 HRD-in -80.79, -61.26 75.18, 6.43 out-out-out SNCooo out-out ActLoopNT-out 13.684 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oioo APE10-dihe-na -88.14, -69.33 APE9-dihe-na -95.59, 155.7 APE8-dihe-in -98.36, 112.37 APE8-rot-na 291.69 APE67-dihe-inflip 93.41, -27.11 -58.56, 130.7 APE12-dist-out 15.321 APE11-dist-in 10.428 APE10-dist-out 9.582 APE9-dist-out 6.196 None None None XRAY 1.41 0.184 0.21 A 302 283 5 0 0 0 [[23, 295]] 1.0 5hnv Serratia sp. OTHER_None_SERSF NEK 2.2e-22 86.3 1 248 248 182 183 184 186 188 52 89 93 162 164 163 165 225 210 205 204 203 202 201 200 199 119 PpkA N terminal
OTHER None A0ACD6BAW3_SERSF 5X1QA A0ACD6BAW3 11 298 302.0 ATP:401 ATPlike Inactive DFGin 5.865 14.558 ABAminus -93.66, -25.98 -170.98, 138.82 -108.48, 3.27 301.84, 148.6 67.38, 20.55 in-out in 9.63 Saltbr-out 4.483 HRD-in -78.8, -61.79 72.35, 9.48 out-out-out SNCooo out-out ActLoopNT-out 13.651 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oioo APE10-dihe-na -91.65, -68.57 APE9-dihe-na -94.63, 156.7 APE8-dihe-in -100.49, 112.2 APE8-rot-na 291.2 APE67-dihe-inflip 90.51, -24.59 -59.25, 132.18 APE12-dist-out 15.327 APE11-dist-in 10.443 APE10-dist-out 9.615 APE9-dist-out 6.227 None None None XRAY 1.602 0.181 0.212 A 302 283 5 0 0 0 [[23, 295]] 1.0 5x1q Serratia sp. OTHER_None_SERSF NEK 2.2e-22 86.3 1 248 248 182 183 184 186 188 52 89 93 162 164 163 165 225 210 205 204 203 202 201 200 199 119 PpkA N terminal

Ligand: ATP

Total number of chains: 67
Active chains: 30
Total number of genes: 23
Spatial label Dihedral label Number of Chains Percent Representative
DFGin BLAminus 44 65.7% 1RDQE
DFGin None 12 17.9% 4CYIA
DFGin BLBminus 3 4.5% 7Z9TBBB
DFGin ABAminus 2 3.0% 5HNVA
DFGin BLBplus 2 3.0% 8HOAA
DFGin BLBtrans 2 3.0% 5D9HB
None None 2 3.0% 4FI1A
All chains - renumbered by
Uniprot PDB Alignment

Hover over column headers for tooltip help

Group Gene SwissprotID PDB UniprotID First_obs_res Last_obs_res Length_Unp Ligand Ligand_type Activity_label Spatial_label Phe_Glu4_dis Phe_Lys_dis Dihedral_label XDFG
φ,ψ		 DFG-Asp
φ,ψ		 DFG-Phe
φ,ψ		 DFG-Phe
χ1,χ2		 DFG-Gly
φ,ψ		 ChelixSaltbr_label Chelix_label Lys_Glu_dis Saltbr_label LysNZ_GluOE_dis HRD_label His φ,ψ Arg φ,ψ SNC_label SNCpymol_label ActLoop_label ActLoopNT_label DFG6_XHRD_dis ActLoopCT_label APEtype APEdihe_label APEdist_label APE10_dihe_label APE10 φ,ψ APE9_dihe_label APE9 φ,ψ APE8_dihe_label APE8 φ,ψ APE8_rotamer_label APE8 χ1 APE67_label APE6 φ,ψ APE7 φ,ψ APE12_dist_label APE12_DFG4_dis APE11_dist_label APE11_DFG4_dis APE10_dist_label APE10_DFG4_dis APE9_dist_label APE9_Arg_dis Chain_mut Chain_phos Modified_aa Method Resolution Rvalue FreeRvalue Chain_id ChainLen Ordered_residues DomainBreak ActLoopLength ActLoopResolvedResidues ActLoopDisorderedResidues Kinase_domains_Unp N_Kinase_domains_Unp pdb Species Kincore_name hmm Evalue Score hmmbeg hmmend hmmlen XDFGnum DFGnum PHEnum DFG4num DFG6num LYSnum GLUnum GLU4num XHRDnum ARGnum HRDnum HRDaspnum aFaspnum APEnum APE6num APE7num APE8num APE9num APE10num APE11num APE12num Hinge1num Protein_name
TKL BRI1 BRI1_ARATH 5LPYA O22476 867 1160 1196.0 ATP:1200 ATPlike Active DFGin 5.175 15.203 BLAminus -134.16, 179.9 60.37, 82.56 -100.0, 17.51 285.92, 71.71 -57.07, -20.27 in-in in 8.892 Saltbr-in 3.152 HRD-in -70.7, -49.88 77.86, -1.82 in-in-in SNCiii in-in ActLoopNT-in 2.908 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -111.47, 151.76 APE9-dihe-na 140.48, 176.99 APE8-dihe-in -121.99, 138.13 APE8-rot-in 307.91 APE67-dihe-inflip 92.03, -10.16 -52.79, 133.04 APE12-dist-in 9.609 APE11-dist-in 11.524 APE10-dist-in 5.721 APE9-dist-in 3.885 T872A TPO1039,SEP1042,SEP1044,SEP1060 TPO1039,SEP1042,SEP1044,SEP1060 XRAY 2.3 0.203 0.248 A 296 286 8 0 0 0 [[882, 1157]] 1.0 5lpy Arabidopsis thaliana TKL_BRI1_ARATH TKL 2e-63 220.4 4 266 263 1026 1027 1028 1030 1032 911 927 931 1006 1008 1007 1009 1068 1056 1051 1050 1049 1048 1047 1046 1045 957 Protein BRASSINOSTEROID INSENSITIVE 1
TKL FERONIA FERON_ARATH 7XDVA Q9SCZ4 521 815 895.0 ATP:60401 ATPlike None DFGin 6.699 15.572 BLAminus -134.27, 177.47 68.35, 79.21 -98.58, 11.5 282.56, 76.24 -59.84, -20.83 in-none in 8.723 Saltbr-none 999.0 HRD-in -67.4, -48.26 73.32, 1.35 none-in-none SNCnin in-none ActLoopNT-in 2.905 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 147.64 APE8-rot-in 320.48 APE67-dihe-in -72.12, 2.13 -58.53, -58.12 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.97 0.172 0.213 A 313 283 12 0 0 12 [[535, 809]] 1.0 7xdv Arabidopsis thaliana TKL_FERONIA_ARATH TKL 8.2e-57 198.7 3 266 264 678 679 680 682 684 565 581 585 658 660 659 661 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
TKL FERONIA FERON_ARATH 7XDVB Q9SCZ4 522 816 895.0 ATP:60401 ATPlike None DFGin 6.676 15.7 BLAminus -133.75, 179.29 66.82, 78.34 -97.78, 11.62 279.93, 76.8 -60.95, -21.55 in-none in 8.917 Saltbr-none 999.0 HRD-in -65.85, -46.61 72.82, 0.74 none-in-none SNCnin in-none ActLoopNT-in 2.856 ActLoopCT-none nonTYR APEdihe_aanii APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 149.11 APE8-rot-in 319.48 APE67-dihe-in -72.05, 2.55 -59.63, -58.54 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 1.97 0.172 0.213 B 313 283 12 0 0 12 [[535, 809]] 1.0 7xdv Arabidopsis thaliana TKL_FERONIA_ARATH TKL 8.2e-57 198.7 3 266 264 678 679 680 682 684 565 581 585 658 660 659 661 720 708 703 702 701 700 699 698 697 611 Receptor-like protein kinase FERONIA
OTHER LANKC A0A6H0TJ16_BACTU 8SAMA A0A6H0TJ16 1 862 872.0 ATP:60902 ATPlike None DFGin 6.64 14.881 BLAminus -119.81, 176.45 65.16, 86.81 -107.13, 32.95 280.75, 71.48 -74.73, -19.84 in-in in 7.41 Saltbr-in 2.775 HRD-na-- -76.54, -26.64 101.12, -25.28 in-in-none SNCiin in-none ActLoopNT-in 2.75 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.15 0.205 0.251 A 904 845 0 0 0 0 [[228, 410]] 1.0 8sam Bacillus thuringiensis serovar andalousiensis OTHER_LANKC_BACTU CAMK 1.4e-13 57.3 1 164 164 381 382 383 385 387 257 279 283 361 363 362 364 0 0 0 0 0 0 0 0 0 310 Class III lanthionine synthetase LanKC
OTHER LANKC A0A6H0TJ16_BACTU 8SAMB A0A6H0TJ16 1 862 872.0 ATP:60901 ATPlike Inactive DFGin 6.749 15.009 BLAminus -116.86, 172.09 66.52, 88.25 -108.59, 34.42 278.94, 73.78 -73.89, -19.99 in-out in 7.479 Saltbr-out 3.865 HRD-na-- -85.28, 118.03 -78.23, 6.03 out-in-none SNCoin in-none ActLoopNT-in 2.764 ActLoopCT-none nonTYR APEdihe_aannn APEdist_nnnn APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 999.0 APE8-dihe-none 999.0, 999.0 APE8-rot-none 999.0 APE67-dihe-none 999.0, 999.0 999.0, 999.0 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-none 999.0 None None None XRAY 2.15 0.205 0.251 B 904 844 0 0 0 0 [[228, 410]] 1.0 8sam Bacillus thuringiensis serovar andalousiensis OTHER_LANKC_BACTU CAMK 1.4e-13 57.3 1 164 164 381 382 383 385 387 257 279 283 361 363 362 364 0 0 0 0 0 0 0 0 0 310 Class III lanthionine synthetase LanKC
AGC GRK1 GRK1_BOVIN 3T8OA P28327 30 532 561.0 ATP:562 ATPlike Active DFGin 6.784 13.652 BLAminus -147.61, 176.5 66.51, 86.5 -106.39, 20.07 278.45, 121.96 -78.51, -8.51 in-in in 9.131 Saltbr-in 2.946 HRD-in -72.08, -59.57 74.93, 15.13 in-in-in SNCiii in-in ActLoopNT-in 3.034 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -126.6, 145.4 APE9-dihe-na 140.82, -165.62 APE8-dihe-in -114.33, 123.31 APE8-rot-in 302.45 APE67-dihe-inflip 90.49, -9.25 -48.36, 136.06 APE12-dist-in 10.419 APE11-dist-in 11.645 APE10-dist-in 5.795 APE9-dist-in 4.276 L166K None None XRAY 2.5 0.209 0.245 A 543 493 0 0 0 0 [[187, 452]] 1.0 3t8o Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C4WA P28327 31 533 561.0 ATP:562 ATPlike Active DFGin 6.587 13.314 BLAminus -157.51, 175.0 67.79, 80.23 -106.97, 21.1 277.77, 138.55 -72.95, -18.52 in-in in 8.671 Saltbr-in 2.659 HRD-in -67.86, -51.97 60.46, 12.85 in-in-in SNCiii in-in ActLoopNT-in 2.897 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.73, 153.77 APE9-dihe-na 125.45, -175.95 APE8-dihe-in -101.44, 127.92 APE8-rot-in 301.93 APE67-dihe-inflip 97.46, -21.92 -46.81, 133.28 APE12-dist-in 10.007 APE11-dist-in 11.248 APE10-dist-in 5.534 APE9-dist-in 3.508 None TPO8 TPO8 XRAY 2.7 0.192 999.0 A 543 494 0 0 0 0 [[187, 452]] 1.0 3c4w Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C4WB P28327 5 533 561.0 ATP:562 ATPlike Active DFGin 5.963 13.111 BLAminus -155.04, 178.49 64.64, 79.84 -103.28, 19.03 277.57, 109.21 -72.3, -19.68 in-in in 8.548 Saltbr-in 2.84 HRD-in -67.79, -54.67 64.69, 11.83 in-in-in SNCiii in-in ActLoopNT-in 2.958 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.45, 154.48 APE9-dihe-na 126.08, -175.35 APE8-dihe-in -101.18, 126.91 APE8-rot-in 300.91 APE67-dihe-inflip 94.23, -17.08 -47.18, 130.86 APE12-dist-in 10.103 APE11-dist-in 11.254 APE10-dist-in 5.545 APE9-dist-in 3.534 None TPO8 TPO8 XRAY 2.7 0.192 999.0 B 543 519 0 0 0 0 [[187, 452]] 1.0 3c4w Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C4XA P28327 30 533 561.0 ATP:562 ATPlike Active DFGin 6.392 13.294 BLAminus -153.36, -178.73 56.38, 83.66 -101.23, 19.01 282.86, 141.85 -58.01, -33.04 in-in in 8.623 Saltbr-in 2.825 HRD-in -65.41, -52.58 62.44, 13.36 in-in-in SNCiii in-in ActLoopNT-in 2.96 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -170.48, 144.22 APE9-dihe-na 128.55, -174.69 APE8-dihe-in -103.7, 129.98 APE8-rot-in 314.1 APE67-dihe-inflip 101.04, -22.84 -50.28, 132.61 APE12-dist-in 10.283 APE11-dist-in 11.237 APE10-dist-in 5.726 APE9-dist-in 3.827 None None None XRAY 2.9 0.193 999.0 A 543 496 0 0 0 0 [[187, 452]] 1.0 3c4x Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC GRK1 GRK1_BOVIN 3C4XB P28327 31 533 561.0 ATP:562 ATPlike Active DFGin 5.903 13.063 BLAminus -149.62, 174.69 57.3, 76.73 -95.24, 8.98 282.05, 96.12 -51.11, -35.54 in-in in 8.642 Saltbr-in 2.675 HRD-in -62.32, -48.48 63.55, 4.44 in-in-in SNCiii in-in ActLoopNT-in 3.043 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -162.42, 143.72 APE9-dihe-na 129.46, -175.16 APE8-dihe-in -98.28, 125.3 APE8-rot-in 312.69 APE67-dihe-inflip 98.15, -18.1 -45.11, 129.51 APE12-dist-in 10.201 APE11-dist-in 11.247 APE10-dist-in 5.61 APE9-dist-in 3.639 None None None XRAY 2.9 0.193 999.0 B 543 475 0 0 0 0 [[187, 452]] 1.0 3c4x Bos taurus AGC_GRK1_BOVIN AGC 3.1e-80 275.1 4 260 257 331 332 333 335 337 216 235 239 311 313 312 314 371 359 354 353 352 351 350 349 348 265 Rhodopsin kinase GRK1
AGC PRKACA KAPCA_BOVIN 9DW9G P00517 13 351 351.0 ATP:401 ATPlike Active DFGin 6.569 15.126 BLAminus -133.9, -169.96 59.46, 64.31 -83.85, 33.99 275.29, 73.58 -66.33, -24.36 in-in in 9.499 Saltbr-in 3.217 HRD-in -92.3, -53.34 68.25, 14.14 in-in-in SNCiii in-in ActLoopNT-in 3.08 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -153.91, 151.76 APE9-dihe-na 126.66, -174.62 APE8-dihe-in -92.84, 130.69 APE8-rot-in 299.41 APE67-dihe-in -68.55, -23.13 -58.33, -34.44 APE12-dist-in 8.703 APE11-dist-in 11.563 APE10-dist-in 6.17 APE9-dist-in 4.568 None TPO198 TPO198 EM 2.8 999.0 999.0 G 351 328 0 0 0 0 [[44, 298]] 1.0 9dw9 Bos taurus AGC_PRKACA_BOVIN AGC 1.3e-94 322.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_BOVIN 1Q24A P00517 15 351 351.0 ATP:60400 ATPlike Active DFGin 5.983 14.319 BLAminus -113.95, 178.0 66.86, 85.15 -103.99, 32.82 274.7, 64.8 -65.44, -25.66 in-in in 8.779 Saltbr-in 2.742 HRD-in -93.22, -55.61 73.46, 14.95 in-in-in SNCiii in-in ActLoopNT-in 3.09 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -155.66, 162.77 APE9-dihe-na 133.15, -143.39 APE8-dihe-in -135.22, 127.61 APE8-rot-in 301.89 APE67-dihe-in -67.43, -30.61 -42.63, -46.05 APE12-dist-in 8.036 APE11-dist-in 11.447 APE10-dist-in 6.024 APE9-dist-in 3.486 V124A,L174M TPO198,SEP339 TPO198,SEP339 XRAY 2.6 0.202 0.25 A 350 337 0 0 0 0 [[44, 298]] 1.0 1q24 Bos taurus AGC_PRKACA_BOVIN AGC 4.8e-94 320.4 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
OTHER PAN3 PAN3_CHATD 4CYIA G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.585 12.852 None -92.38, -13.16 -130.85, 61.75 -94.99, 144.51 286.93, 999.0 79.52, -4.52 out-na out 13.591 Saltbr-na 999.0 HRD-out -83.98, 84.54 -50.92, -35.91 na-out-na SNCaoa out-na ActLoopNT-out 7.062 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -80.88, -42.8 APE9-dihe-na -64.32, -40.93 APE8-dihe-na -99.24, 17.32 APE8-rot-na 300.48 APE67-dihe-na -73.05, -48.17 -58.31, -53.55 APE12-dist-na 4.897 APE11-dist-na 5.543 APE10-dist-na 5.105 APE9-dist-na 11.572 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 A 438 405 0 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIB G0S0Y3 213 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.616 12.918 None -91.62, -15.83 -130.65, 63.54 -94.89, 145.11 286.33, 999.0 77.48, -4.88 out-na out 13.58 Saltbr-na 999.0 HRD-out -84.8, 85.11 -51.08, -35.56 na-out-na SNCaoa out-na ActLoopNT-out 7.175 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -82.17, -41.93 APE9-dihe-na -64.26, -40.58 APE8-dihe-na -98.12, 16.28 APE8-rot-na 298.69 APE67-dihe-na 80.12, -45.62 -60.06, 122.74 APE12-dist-na 4.893 APE11-dist-na 5.478 APE10-dist-na 5.079 APE9-dist-na 11.87 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 B 438 406 8 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIC G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.492 12.647 None -89.83, -13.71 -129.71, 95.5 -125.66, 144.13 285.48, 999.0 76.65, -4.79 out-na out 13.568 Saltbr-na 999.0 HRD-out -84.9, 84.38 -51.27, -35.99 na-out-na SNCaoa out-na ActLoopNT-out 7.036 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.46, -42.97 APE9-dihe-na -65.29, -40.87 APE8-dihe-na -98.03, 18.1 APE8-rot-na 300.5 APE67-dihe-na -80.64, -42.62 -57.0, -52.24 APE12-dist-na 4.87 APE11-dist-na 5.412 APE10-dist-na 5.104 APE9-dist-na 11.702 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 C 438 397 8 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYID G0S0Y3 214 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.581 12.83 None -92.56, -14.61 -129.54, 61.33 -91.03, 145.16 286.17, 999.0 78.34, -3.87 out-na out 13.632 Saltbr-na 999.0 HRD-out -84.73, 84.5 -51.45, -36.17 na-out-na SNCaoa out-na ActLoopNT-out 6.98 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -82.5, -42.63 APE9-dihe-na -63.84, -39.93 APE8-dihe-na -97.69, 15.27 APE8-rot-na 300.06 APE67-dihe-na 82.88, -51.63 -61.5, 124.95 APE12-dist-na 4.849 APE11-dist-na 5.59 APE10-dist-na 5.161 APE9-dist-na 11.613 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 D 438 407 8 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIE G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.538 12.767 None -90.87, -14.73 -130.14, 65.48 -95.4, 143.11 286.9, 999.0 77.19, -4.14 out-na out 13.933 Saltbr-na 999.0 HRD-out -83.54, 85.23 -50.62, -36.04 na-out-na SNCaoa out-na ActLoopNT-out 6.962 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.29, -42.51 APE9-dihe-na -65.13, -42.05 APE8-dihe-na -99.46, 17.91 APE8-rot-na 300.53 APE67-dihe-na -82.88, -16.1 -58.82, -52.89 APE12-dist-na 4.867 APE11-dist-na 5.506 APE10-dist-na 4.99 APE9-dist-na 11.652 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 E 438 394 10 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIF G0S0Y3 213 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.657 12.928 None -90.71, -14.62 -131.6, 64.5 -94.2, 145.33 287.42, 999.0 78.97, -5.05 out-na out 13.619 Saltbr-na 999.0 HRD-out -84.32, 83.81 -51.72, -36.16 na-out-na SNCaoa out-na ActLoopNT-out 7.068 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.37, -43.07 APE9-dihe-na -65.03, -40.26 APE8-dihe-na -97.58, 14.32 APE8-rot-na 301.7 APE67-dihe-na 82.79, -63.67 -61.76, 133.26 APE12-dist-na 4.897 APE11-dist-na 5.471 APE10-dist-na 4.981 APE9-dist-na 11.745 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 F 438 408 8 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIG G0S0Y3 212 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.345 12.727 None -90.69, -14.9 -130.76, 66.96 -94.98, 143.34 287.45, 999.0 77.29, -3.15 out-na out 13.686 Saltbr-na 999.0 HRD-out -84.86, 86.26 -50.94, -35.45 na-out-na SNCaoa out-na ActLoopNT-out 6.956 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.27, -42.88 APE9-dihe-na -64.53, -40.74 APE8-dihe-na -98.57, 20.38 APE8-rot-na 300.7 APE67-dihe-na -82.95, -50.87 -54.99, -52.34 APE12-dist-na 4.886 APE11-dist-na 5.441 APE10-dist-na 4.99 APE9-dist-na 11.838 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 G 438 397 11 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYIH G0S0Y3 215 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.548 12.993 None -92.58, -12.35 -130.21, 41.87 -74.5, 144.28 287.27, 999.0 78.55, -5.47 out-na out 13.565 Saltbr-na 999.0 HRD-out -84.2, 83.95 -50.63, -35.15 na-out-na SNCaoa out-na ActLoopNT-out 7.113 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -81.74, -43.44 APE9-dihe-na -64.3, -40.98 APE8-dihe-na -98.31, 13.33 APE8-rot-na 300.84 APE67-dihe-na 84.19, -53.66 -61.5, 130.17 APE12-dist-na 4.897 APE11-dist-na 5.551 APE10-dist-na 5.004 APE9-dist-na 11.679 None None MSE220,MSE305,MSE422,MSE494,MSE501,MSE533,MSE583,MSE587,MSE619 XRAY 2.42 0.193 0.234 H 438 407 7 0 0 0 [[244, 507]] 1.0 4cyi Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJA G0S0Y3 207 630 640.0 ATP:900 ATPlike Pseudo DFGin 8.634 13.143 None -107.98, -0.69 -128.2, 34.36 -65.03, -50.53 266.85, 999.0 -67.72, -27.44 out-na out 13.824 Saltbr-na 999.0 HRD-out -72.25, 117.57 -98.06, -29.9 na-out-na SNCaoa out-na ActLoopNT-out 6.734 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -76.94, -48.66 APE9-dihe-na -63.83, -32.83 APE8-dihe-na -105.44, 19.22 APE8-rot-na 294.5 APE67-dihe-na -75.63, -42.57 -53.51, -50.74 APE12-dist-na 4.896 APE11-dist-na 5.565 APE10-dist-na 4.767 APE9-dist-na 12.093 None None None XRAY 2.59 0.185 0.221 A 438 403 9 0 0 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJB G0S0Y3 207 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.657 13.407 None -109.51, -3.14 -128.47, 33.06 -65.31, -51.07 267.08, 999.0 -68.09, -25.9 out-na out 13.607 Saltbr-na 999.0 HRD-out -72.34, 112.57 -93.58, -28.7 na-out-na SNCaoa out-na ActLoopNT-out 6.74 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.81, -47.86 APE9-dihe-na -64.66, -32.92 APE8-dihe-na -101.7, 13.23 APE8-rot-na 292.51 APE67-dihe-na 83.46, -7.05 -62.34, 118.45 APE12-dist-na 4.827 APE11-dist-na 5.687 APE10-dist-na 4.961 APE9-dist-na 11.892 None None None XRAY 2.59 0.185 0.221 B 438 412 10 0 0 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJC G0S0Y3 210 632 640.0 ATP:900 ATPlike Pseudo DFGin 8.673 13.164 None -108.29, -3.21 -129.06, 34.16 -64.55, -50.26 267.61, 999.0 -68.23, -27.03 out-na out 13.722 Saltbr-na 999.0 HRD-out -71.32, 109.68 -92.82, -27.84 na-out-na SNCaoa out-na ActLoopNT-out 6.928 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -75.12, -48.05 APE9-dihe-na -64.49, -35.42 APE8-dihe-na -104.77, 18.2 APE8-rot-na 294.69 APE67-dihe-na -54.66, -46.82 -53.38, -67.98 APE12-dist-na 4.886 APE11-dist-na 5.663 APE10-dist-na 4.931 APE9-dist-na 11.895 None None None XRAY 2.59 0.185 0.221 C 438 404 8 0 0 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
OTHER PAN3 PAN3_CHATD 4CYJD G0S0Y3 207 631 640.0 ATP:900 ATPlike Pseudo DFGin 8.73 13.246 None -109.91, -2.89 -127.7, 32.83 -63.98, -50.83 267.28, 999.0 -68.06, -27.82 out-na out 13.683 Saltbr-na 999.0 HRD-out -71.89, 115.33 -92.98, -30.13 na-out-na SNCaoa out-na ActLoopNT-out 6.66 ActLoopCT-na noAPE APEdihe_aaaaa APEdist_aaaa APE10-dihe-na -72.1, -45.9 APE9-dihe-na -60.82, -48.55 APE8-dihe-na -95.53, 14.82 APE8-rot-na 272.71 APE67-dihe-na -68.99, -42.68 -59.32, -45.4 APE12-dist-na 4.893 APE11-dist-na 5.689 APE10-dist-na 4.875 APE9-dist-na 11.937 None None None XRAY 2.59 0.185 0.221 D 438 411 11 0 0 0 [[244, 507]] 1.0 4cyj Chaetomium thermophilum OTHER_PAN3_CHATD PAN3 6.7e-56 200.2 4 286 283 410 411 412 414 416 288 304 308 390 392 391 393 434 426 421 420 419 418 417 416 415 338 PAN2-PAN3 deadenylation complex subunit PAN3
AGC PRKACA KAPCA_CRIGR 6EMAA P25321 12 351 351.0 ATP:60401 ATPlike Active DFGin 6.847 14.028 BLAminus -121.3, 163.01 76.03, 95.19 -107.48, 29.41 285.05, 72.84 -63.27, -23.25 in-in in 8.581 Saltbr-in 2.912 HRD-in -88.06, -51.23 73.05, 9.34 in-in-in SNCiii in-in ActLoopNT-in 2.843 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.85, 162.03 APE9-dihe-na 127.51, -167.2 APE8-dihe-in -113.51, 133.85 APE8-rot-in 299.54 APE67-dihe-in -58.99, -24.47 -49.7, -50.19 APE12-dist-in 8.208 APE11-dist-in 11.434 APE10-dist-in 5.777 APE9-dist-in 3.585 None SEP11,SEP140,TPO198,SEP339 SEP11,SEP140,TPO198,SEP339 XRAY 1.88 0.184 0.213 A 353 340 0 0 0 0 [[44, 298]] 1.0 6ema Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_CRIGR 6Y8CA P25321 13 351 351.0 ATP:60402 ATPlike Active DFGin 5.727 14.302 BLAminus -123.99, 172.57 69.5, 82.73 -92.15, 25.74 279.44, 63.0 -58.78, -31.82 in-in in 9.166 Saltbr-in 2.638 HRD-in -96.49, -52.39 69.1, 12.65 in-in-in SNCiii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.28, 160.42 APE9-dihe-na 122.78, -169.96 APE8-dihe-in -106.17, 134.07 APE8-rot-in 304.81 APE67-dihe-in -60.24, -22.7 -48.33, -48.43 APE12-dist-in 8.044 APE11-dist-in 11.517 APE10-dist-in 5.939 APE9-dist-in 3.895 None TPO198,SEP339 TPO198,SEP339 XRAY 1.76 0.162 0.19 A 353 339 0 0 0 0 [[44, 298]] 1.0 6y8c Cricetulus griseus AGC_PRKACA_CRIGR AGC 6.6e-95 323.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
TKL RIPK A0A811MC32_9POAL 8HOAA A0A811MC32 90 387 441.0 ATP:60701,HX2:60702 ATPlike,Allosteric Inactive DFGin 6.061 12.606 BLBplus -114.97, 161.69 65.77, 20.85 -71.65, 141.67 50.94, 88.04 74.58, 5.91 out-none out 13.156 Saltbr-none 999.0 HRD-out -77.34, 149.41 -82.88, -37.27 none-none-out SNCnno none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 19.65 APE8-dihe-out -73.34, -23.03 APE8-rot-out 81.86 APE67-dihe-out 95.0, 11.7 -84.03, -15.48 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 8.206 None None None XRAY 1.676 0.188 0.213 A 326 271 27 0 0 16 [[105, 385]] 1.0 8hoa Miscanthus lutarioriparius TKL_RIPK_9POAL TKL 1.9e-59 207.4 4 266 263 253 254 255 257 259 141 157 161 233 235 234 236 295 283 278 277 276 275 274 273 272 187 non-specific serine/threonine protein kinase
AGC PRKACA KAPCA_MOUSE 1ATPE P05132 16 351 351.0 ATP:60355 ATPlike Inactive DFGin 6.23 14.588 BLAminus -105.27, -165.6 48.73, 87.06 -105.12, 16.76 267.19, 75.22 -52.19, -32.07 in-out in 9.161 Saltbr-out 3.634 HRD-in -88.29, -43.64 51.81, 19.16 out-in-in SNCoii in-in ActLoopNT-in 2.808 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -135.21, 146.28 APE9-dihe-na 146.09, -156.15 APE8-dihe-in -133.3, 119.84 APE8-rot-in 299.98 APE67-dihe-in -65.71, -15.81 -24.26, -60.76 APE12-dist-in 8.353 APE11-dist-in 11.41 APE10-dist-in 5.706 APE9-dist-in 3.99 None TPO198,SEP339 TPO198,SEP339 XRAY 2.2 0.177 999.0 E 350 336 0 0 0 0 [[44, 298]] 1.0 1atp Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3FJQE P05132 16 351 351.0 ATP:60403 ATPlike Active DFGin 5.671 14.459 BLAminus -119.42, 178.78 63.28, 80.04 -91.81, 23.31 270.73, 57.82 -56.09, -30.86 in-in in 9.149 Saltbr-in 2.834 HRD-in -91.33, -52.39 67.42, 13.87 in-in-in SNCiii in-in ActLoopNT-in 2.906 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.19, 160.44 APE9-dihe-na 133.42, -155.21 APE8-dihe-in -125.75, 136.86 APE8-rot-in 304.0 APE67-dihe-in -61.0, -22.29 -48.87, -49.39 APE12-dist-in 8.086 APE11-dist-in 11.408 APE10-dist-in 5.838 APE9-dist-in 3.518 None TPO198,SEP339 TPO198,SEP339 XRAY 1.6 0.179 0.205 E 350 336 0 0 0 0 [[44, 298]] 1.0 3fjq Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DH1A P05132 16 351 351.0 ATP:60402 ATPlike Active DFGin 6.234 14.38 BLAminus -130.7, 167.11 69.97, 89.08 -103.01, 26.92 273.93, 57.95 -52.62, -33.38 in-in in 8.931 Saltbr-in 3.01 HRD-in -75.69, -51.31 65.95, 10.85 in-in-in SNCiii in-in ActLoopNT-in 2.887 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -144.97, 163.54 APE9-dihe-na 128.87, -151.55 APE8-dihe-in -123.52, 135.53 APE8-rot-in 304.09 APE67-dihe-in -55.69, -26.94 -40.23, -59.36 APE12-dist-in 8.169 APE11-dist-in 11.557 APE10-dist-in 5.95 APE9-dist-in 3.545 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.0 0.199 0.234 A 350 336 0 0 0 0 [[44, 298]] 1.0 4dh1 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DH3A P05132 16 351 351.0 ATP:60403 ATPlike Active DFGin 5.984 14.379 BLAminus -125.47, 176.75 61.82, 79.89 -92.16, 24.39 276.69, 54.39 -43.39, -47.09 in-in in 9.021 Saltbr-in 2.723 HRD-in -82.56, -48.22 66.04, -2.33 in-in-in SNCiii in-in ActLoopNT-in 2.931 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -145.47, 165.55 APE9-dihe-na 126.96, -149.27 APE8-dihe-in -125.58, 130.88 APE8-rot-in 307.35 APE67-dihe-in -57.88, -25.54 -37.95, -56.15 APE12-dist-in 8.225 APE11-dist-in 11.592 APE10-dist-in 6.104 APE9-dist-in 3.74 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.2 0.203 0.233 A 350 336 0 0 0 0 [[44, 298]] 1.0 4dh3 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4DINA P05132 10 351 351.0 ATP:60400 ATPlike Inactive DFGin 5.792 13.144 BLAminus -127.84, -176.29 51.22, 102.02 -109.69, 31.05 287.96, 58.2 -47.08, -31.2 in-in in 8.518 Saltbr-in 3.498 HRD-out -64.69, -78.02 71.93, 51.46 in-in-out SNCiio in-out ActLoopNT-in 2.994 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -152.73, 153.23 APE9-dihe-na 130.84, -154.91 APE8-dihe-in -121.15, 137.05 APE8-rot-out 34.65 APE67-dihe-in -46.77, -45.03 -45.98, -63.1 APE12-dist-in 7.972 APE11-dist-in 10.588 APE10-dist-in 4.997 APE9-dist-in 3.53 None TPO198,SEP339 TPO198,SEP339 XRAY 3.7 0.211 0.293 A 350 342 0 0 0 0 [[44, 298]] 1.0 4din Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.1 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4X6RA P05132 2 351 351.0 ATP:60402 ATPlike Active DFGin 6.133 14.232 BLAminus -118.92, 178.27 64.18, 79.91 -89.21, 11.01 274.1, 55.74 -49.19, -34.95 in-in in 8.804 Saltbr-in 2.729 HRD-in -85.13, -60.38 77.67, -7.87 in-in-in SNCiii in-in ActLoopNT-in 2.718 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -160.34, 156.01 APE9-dihe-na 147.33, -149.7 APE8-dihe-in -130.56, 138.51 APE8-rot-in 291.09 APE67-dihe-in -61.2, -24.8 -52.44, -47.95 APE12-dist-in 8.281 APE11-dist-in 11.246 APE10-dist-in 5.836 APE9-dist-in 3.663 K8C SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.4 0.186 0.234 A 350 350 0 0 0 0 [[44, 298]] 1.0 4x6r Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3X2UA P05132 13 351 351.0 ATP:60501 ATPlike Active DFGin 6.127 14.507 BLAminus -122.24, 178.58 59.36, 87.7 -101.54, 25.28 272.61, 50.83 -59.45, -24.26 in-in in 9.272 Saltbr-in 2.788 HRD-in -89.58, -50.62 64.84, 17.58 in-in-in SNCiii in-in ActLoopNT-in 2.93 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -157.25, 158.3 APE9-dihe-na 134.88, -147.54 APE8-dihe-in -130.4, 131.58 APE8-rot-in 300.12 APE67-dihe-in -61.26, -14.4 -40.08, -55.22 APE12-dist-in 7.912 APE11-dist-in 11.137 APE10-dist-in 5.686 APE9-dist-in 3.427 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 2.4 0.202 0.239 A 357 339 0 0 0 0 [[44, 298]] 1.0 3x2u Mus musculus AGC_PRKACA_MOUSE AGC 1.6e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3X2VA P05132 18 351 351.0 ATP:60403 ATPlike Active DFGin 5.517 14.152 BLAminus -116.69, -175.94 62.92, 80.3 -91.77, 26.26 271.42, 55.44 -51.78, -39.79 in-in in 8.755 Saltbr-in 2.654 HRD-in -92.08, -50.84 67.69, 17.07 in-in-in SNCiii in-in ActLoopNT-in 2.881 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -149.85, 164.45 APE9-dihe-na 134.14, -152.5 APE8-dihe-in -130.83, 133.42 APE8-rot-in 299.77 APE67-dihe-in -58.82, -21.18 -48.96, -48.11 APE12-dist-in 7.998 APE11-dist-in 11.346 APE10-dist-in 5.796 APE9-dist-in 3.415 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.77 0.185 0.23 A 357 334 0 0 0 0 [[44, 298]] 1.0 3x2v Mus musculus AGC_PRKACA_MOUSE AGC 1.6e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3X2WA P05132 13 351 351.0 ATP:60403 ATPlike Active DFGin 5.66 14.39 BLAminus -121.01, -177.68 63.51, 77.56 -90.4, 24.79 270.4, 59.29 -61.83, -28.06 in-in in 8.822 Saltbr-in 2.632 HRD-in -81.34, -52.24 70.22, 11.48 in-in-in SNCiii in-in ActLoopNT-in 2.906 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.19, 162.39 APE9-dihe-na 132.4, -151.44 APE8-dihe-in -129.91, 133.08 APE8-rot-in 300.2 APE67-dihe-in -60.45, -20.83 -45.18, -51.38 APE12-dist-in 8.001 APE11-dist-in 11.44 APE10-dist-in 5.911 APE9-dist-in 3.45 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.7 0.165 0.198 A 357 339 0 0 0 0 [[44, 298]] 1.0 3x2w Mus musculus AGC_PRKACA_MOUSE AGC 1.6e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 4XW5A P05132 15 351 351.0 ATP:60403 ATPlike Active DFGin 5.971 14.222 BLAminus -131.24, 177.82 59.66, 87.19 -93.08, 25.08 282.37, 63.43 -53.77, -29.24 in-in in 9.213 Saltbr-in 2.673 HRD-in -90.87, -48.94 63.52, 13.92 in-in-in SNCiii in-in ActLoopNT-in 2.812 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.24, 155.03 APE9-dihe-na 137.47, -160.98 APE8-dihe-in -110.31, 133.6 APE8-rot-in 304.05 APE67-dihe-in -58.14, -25.36 -48.87, -50.12 APE12-dist-in 8.026 APE11-dist-in 11.601 APE10-dist-in 6.1 APE9-dist-in 3.922 None SEP140,TPO198,SEP339 SEP140,TPO198,SEP339 XRAY 1.95 0.185 0.252 A 356 337 0 0 0 0 [[44, 298]] 1.0 4xw5 Mus musculus AGC_PRKACA_MOUSE AGC 1.5e-94 322.0 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3QAME P05132 2 351 351.0 ATP:60351 ATPlike Active DFGin 5.559 14.19 BLAminus -125.2, -173.2 57.82, 79.24 -94.32, 24.42 273.28, 56.46 -52.36, -33.22 in-in in 8.98 Saltbr-in 2.804 HRD-in -80.54, -55.75 67.52, 12.49 in-in-in SNCiii in-in ActLoopNT-in 2.888 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -161.45, 157.56 APE9-dihe-na 134.84, -152.56 APE8-dihe-in -129.9, 127.65 APE8-rot-in 298.13 APE67-dihe-in -57.31, -20.14 -26.19, -66.74 APE12-dist-in 8.094 APE11-dist-in 11.277 APE10-dist-in 5.806 APE9-dist-in 3.475 E209A TPO198,SEP339 TPO198,SEP339 XRAY 1.92 0.195 0.228 E 350 350 0 0 0 0 [[44, 298]] 1.0 3qam Mus musculus AGC_PRKACA_MOUSE AGC 2.2e-93 318.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 3QALE P05132 2 351 351.0 ATP:60351 ATPlike Active DFGin 5.64 14.401 BLAminus -123.21, -177.09 59.31, 80.89 -94.71, 25.93 269.1, 56.43 -54.28, -32.32 in-in in 9.05 Saltbr-in 2.658 HRD-in -84.64, -51.07 65.64, 14.74 in-in-in SNCiii in-in ActLoopNT-in 2.962 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -152.61, 159.73 APE9-dihe-na 131.58, -155.18 APE8-dihe-in -126.66, 132.34 APE8-rot-in 301.51 APE67-dihe-in -57.77, -23.32 -31.31, -63.36 APE12-dist-in 8.062 APE11-dist-in 11.309 APE10-dist-in 5.744 APE9-dist-in 3.531 R281A TPO198,SEP339 TPO198,SEP339 XRAY 1.7 0.176 0.194 E 350 341 0 0 0 0 [[44, 298]] 1.0 3qal Mus musculus AGC_PRKACA_MOUSE AGC 4.5e-93 317.2 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
AGC PRKACA KAPCA_MOUSE 1RDQE P05132 2 351 351.0 ADP:60599,ATP:60600 ATPlike,ATPlike Active DFGin 5.707 14.515 BLAminus -117.27, 178.71 64.74, 81.19 -90.07, 21.82 270.96, 52.48 -58.25, -31.62 in-in in 9.091 Saltbr-in 2.719 HRD-in -91.16, -53.36 73.19, 12.39 in-in-in SNCiii in-in ActLoopNT-in 2.936 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.91, 159.57 APE9-dihe-na 132.64, -151.85 APE8-dihe-in -127.7, 133.09 APE8-rot-in 298.45 APE67-dihe-in -59.33, -27.24 -47.42, -47.34 APE12-dist-in 8.116 APE11-dist-in 11.414 APE10-dist-in 5.831 APE9-dist-in 3.521 Y205A TPO198,SEP339 TPO198,SEP339 XRAY 1.26 0.132 0.162 E 350 342 0 0 0 0 [[44, 298]] 1.0 1rdq Mus musculus AGC_PRKACA_MOUSE AGC 1.1e-92 315.9 1 260 260 184 185 186 188 190 73 92 96 164 166 165 167 221 209 204 203 202 201 200 199 198 122 cAMP-dependent protein kinase catalytic subunit alpha
CAMK DAPK2 DAPK2_MOUSE 2YAAA Q8VDF3 12 311 370.0 ATP:61302 ATPlike Active DFGin 6.531 14.282 BLAminus -119.44, -173.75 61.63, 82.55 -100.44, 26.82 279.23, 73.82 -61.71, -30.38 in-in in 9.437 Saltbr-in 2.945 HRD-in -69.91, -51.35 70.12, 4.4 in-in-in SNCiii in-in ActLoopNT-in 2.83 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -164.66, 179.02 APE9-dihe-na 88.17, 165.82 APE8-dihe-in -83.03, 124.75 APE8-rot-in 307.34 APE67-dihe-in -54.24, -28.42 -45.93, -43.89 APE12-dist-in 8.679 APE11-dist-in 11.592 APE10-dist-in 6.391 APE9-dist-in 4.926 None None None XRAY 2.3 0.219 0.271 A 361 300 0 0 0 0 [[23, 285]] 1.0 2yaa Mus musculus CAMK_DAPK2_MOUSE CAMK 1.1e-93 319.4 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CAMK DAPK2 DAPK2_MOUSE 2YAAB Q8VDF3 13 311 370.0 ATP:61302 ATPlike Inactive DFGin 6.584 14.289 BLAminus -119.54, -178.65 66.98, 88.67 -108.71, 24.01 280.41, 69.43 -62.37, -28.55 out-out out 10.171 Saltbr-out 5.377 HRD-in -72.87, -55.45 75.11, 6.49 out-in-in SNCoii in-in ActLoopNT-in 2.911 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -174.59, 179.36 APE9-dihe-na 81.98, 166.79 APE8-dihe-in -83.03, 125.4 APE8-rot-in 303.87 APE67-dihe-in -54.18, -26.93 -45.18, -48.55 APE12-dist-in 8.764 APE11-dist-in 11.596 APE10-dist-in 6.43 APE9-dist-in 4.828 None None None XRAY 2.3 0.219 0.271 B 361 299 0 0 0 0 [[23, 285]] 1.0 2yaa Mus musculus CAMK_DAPK2_MOUSE CAMK 1.1e-93 319.4 1 256 256 170 171 172 174 176 52 74 78 146 148 147 149 209 197 192 191 190 189 188 187 186 104 Death-associated protein kinase 2
CMGC MAPK14 MK14_MOUSE 7Z9TBBB P47811 4 353 360.0 87B:401,ATP:402 Type3,Allosteric Inactive DFGin 5.829 15.244 BLBminus -103.34, -178.81 25.47, 89.69 -68.87, -161.65 315.54, 109.9 -76.7, 116.65 out-out out 10.342 Saltbr-out 4.179 HRD-in -67.82, -70.27 93.09, -17.91 out-out-out SNCooo out-out ActLoopNT-out 7.706 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_oooo APE10-dihe-na -124.01, -67.71 APE9-dihe-na -98.04, -13.3 APE8-dihe-out -67.58, -39.12 APE8-rot-in 311.0 APE67-dihe-in -63.55, -21.3 -74.81, -8.77 APE12-dist-out 14.596 APE11-dist-out 16.356 APE10-dist-out 19.352 APE9-dist-out 12.538 None None None XRAY 2.6 0.202 0.254 BBB 359 350 0 0 0 0 [[24, 308]] 1.0 7z9t Mus musculus CMGC_MAPK14_MOUSE CMGC 5e-85 291.4 1 301 301 167 168 169 171 173 53 71 75 147 149 148 150 205 192 187 186 185 184 183 182 181 107 Mitogen-activated protein kinase 14
STE STK39 STK39_MOUSE 5D9HA Q9Z1W9 65 363 556.0 ATP:501 ATPlike Inactive DFGin 5.686 16.437 BLBtrans -110.31, 163.68 60.83, 61.1 -112.91, 152.73 160.61, 82.83 89.94, -129.86 out-out out 13.682 Saltbr-out 14.175 HRD-in -79.34, -55.51 78.38, -0.69 out-out-out SNCooo out-out ActLoopNT-out 7.753 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnoo APE10-dihe-na 999.0, 89.3 APE9-dihe-na 145.31, -162.33 APE8-dihe-in -128.36, 135.86 APE8-rot-out 189.19 APE67-dihe-in -54.38, -21.28 -96.66, 16.8 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 27.054 APE9-dist-out 28.547 None None None XRAY 3.1 0.24 0.269 A 348 290 9 0 0 7 [[75, 349]] 1.0 5d9h Mus musculus STE_STK39_MOUSE STE 1.3e-90 309.2 1 257 257 221 222 223 225 227 104 121 125 201 203 202 204 267 254 249 248 247 246 245 244 243 151 STE20/SPS1-related proline-alanine-rich protein kinase
STE STK39 STK39_MOUSE 5D9HB Q9Z1W9 65 364 556.0 ATP:501 ATPlike Inactive DFGin 5.686 16.557 BLBtrans -110.27, 163.88 60.61, 61.2 -112.96, 152.81 160.68, 82.77 89.89, -127.48 out-out out 13.712 Saltbr-out 13.101 HRD-in -78.11, -50.69 74.23, -12.16 out-out-out SNCooo out-out ActLoopNT-out 7.913 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_nnno APE10-dihe-na 999.0, 999.0 APE9-dihe-na 999.0, 140.15 APE8-dihe-in -87.12, 142.28 APE8-rot-out 185.38 APE67-dihe-in -78.59, -19.5 -91.99, 27.22 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-none 999.0 APE9-dist-out 28.707 None None None XRAY 3.1 0.24 0.269 B 348 293 7 0 0 7 [[75, 349]] 1.0 5d9h Mus musculus STE_STK39_MOUSE STE 1.3e-90 309.2 1 257 257 221 222 223 225 227 104 121 125 201 203 202 204 267 254 249 248 247 246 245 244 243 151 STE20/SPS1-related proline-alanine-rich protein kinase
TKL RIPK4 RIPK4_MOUSE 5WNIA Q9ERK0 9 288 786.0 ATP:403 ATPlike Inactive DFGin 5.031 14.764 BLAminus -137.21, -171.18 63.31, 81.36 -101.4, 15.3 283.28, 78.59 -51.45, -36.22 in-in in 8.646 Saltbr-in 2.482 HRD-in -76.93, -54.51 67.9, 5.7 in-in-out SNCiio in-out ActLoopNT-in 3.204 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 127.03 APE9-dihe-na -72.21, -45.63 APE8-dihe-out -54.13, -30.5 APE8-rot-out 51.09 APE67-dihe-in -56.9, -38.97 -54.07, -35.71 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 15.458 APE9-dist-out 11.387 D143N None None XRAY 2.65 0.204 0.248 A 342 263 17 0 0 13 [[19, 285]] 1.0 5wni Mus musculus TKL_RIPK4_MOUSE TKL 1.4e-74 257.0 4 266 263 160 161 162 164 166 51 69 73 140 142 141 143 205 191 186 185 184 183 182 181 180 97 Receptor-interacting serine/threonine-protein kinase 4
CAMK PHKG1 PHKG1_RABIT 2PHKA P00518 15 291 387.0 ATP:60381 ATPlike Active DFGin 6.355 14.931 BLAminus -137.29, -164.32 48.12, 82.5 -104.58, 35.29 286.95, 71.57 -66.18, -30.51 in-in in 9.223 Saltbr-in 2.867 HRD-in -75.14, -51.03 75.46, 17.9 in-in-in SNCiii in-in ActLoopNT-in 2.885 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -151.02, 157.52 APE9-dihe-na 142.39, -153.7 APE8-dihe-in -119.73, 129.29 APE8-rot-in 312.14 APE67-dihe-in -75.97, -3.06 -46.22, -51.97 APE12-dist-in 9.188 APE11-dist-in 12.037 APE10-dist-in 6.565 APE9-dist-in 4.187 None None None XRAY 2.6 0.253 0.3 A 277 277 0 0 0 0 [[20, 288]] 1.0 2phk Oryctolagus cuniculus CAMK_PHKG1_RABIT CAMK 3e-86 294.8 1 256 256 167 168 169 171 173 49 74 78 147 149 148 150 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK PHKG1 PHKG1_RABIT 1QL6A P00518 12 292 387.0 ATP:60301 ATPlike Active DFGin 6.367 14.614 BLAminus -136.63, -170.42 53.21, 74.77 -97.04, 26.39 287.52, 75.09 -70.06, -14.72 in-in in 9.205 Saltbr-in 3.1 HRD-in -59.97, -49.78 67.92, 7.3 in-in-in SNCiii in-in ActLoopNT-in 2.896 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -154.76, 155.97 APE9-dihe-na 109.55, 169.96 APE8-dihe-in -76.43, 127.92 APE8-rot-in 308.32 APE67-dihe-in -67.24, -23.63 -51.61, -34.62 APE12-dist-in 9.259 APE11-dist-in 11.445 APE10-dist-in 6.11 APE9-dist-in 4.369 E183S None None XRAY 2.4 0.24 0.33 A 298 281 0 0 0 0 [[20, 288]] 1.0 1ql6 Oryctolagus cuniculus CAMK_PHKG1_RABIT CAMK 5.1e-86 294.1 1 256 256 167 168 169 171 173 49 74 78 147 149 148 150 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
CAMK PHKG1 PHKG1_RABIT 1PHKA P00518 16 292 387.0 ATP:60381 ATPlike Active DFGin 6.147 14.336 BLAminus -126.89, -173.45 56.12, 79.25 -99.09, 29.57 290.92, 76.23 -67.63, -19.58 in-in in 8.993 Saltbr-in 2.825 HRD-in -77.33, -46.36 68.03, 5.86 in-in-in SNCiii in-in ActLoopNT-in 2.957 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -156.41, 147.14 APE9-dihe-na 116.4, 168.87 APE8-dihe-in -72.55, 120.48 APE8-rot-in 295.05 APE67-dihe-in -62.26, -27.58 -41.92, -42.38 APE12-dist-in 8.836 APE11-dist-in 11.43 APE10-dist-in 6.157 APE9-dist-in 4.492 None None None XRAY 2.2 0.21 0.288 A 298 277 0 0 0 0 [[20, 288]] 1.0 1phk Oryctolagus cuniculus CAMK_PHKG1_RABIT CAMK 4e-86 294.4 1 256 256 167 168 169 171 173 49 74 78 147 149 148 150 212 194 189 188 187 186 185 184 183 105 Phosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform
STE MAP2K1 MP2K1_RABIT 2Y4IC P29678 37 381 393.0 ATP:1382 ATPlike Inactive DFGin 6.197 13.756 BLBplus -151.54, -176.33 53.75, 29.39 -91.07, 130.43 56.39, 97.48 -61.44, 113.3 out-out out 16.132 Saltbr-out 15.794 HRD-in -53.6, -47.94 74.29, -22.1 out-out-out SNCooo out-out ActLoopNT-out 9.9 ActLoopCT-out nonTYR APEdihe_aaooo APEdist_oooo APE10-dihe-na -108.6, -60.21 APE9-dihe-na 86.78, -165.04 APE8-dihe-out -116.15, -0.77 APE8-rot-out 172.84 APE67-dihe-out -107.13, 167.3 -126.53, 122.47 APE12-dist-out 16.259 APE11-dist-out 19.161 APE10-dist-out 21.278 APE9-dist-out 14.867 None None None XRAY 3.46 0.233 0.293 C 395 313 32 0 0 0 [[68, 361]] 1.0 2y4i Oryctolagus cuniculus STE_MAP2K1_RABIT STE 2.5e-97 331.3 1 257 257 207 208 209 211 213 97 114 118 187 189 188 190 245 233 228 227 226 225 224 223 222 144 Dual specificity mitogen-activated protein kinase kinase 1
OTHER FLS2 FLS2_ORYSJ 8JUPA Q0JA29 861 1176 1183.0 ATP:60401 ATPlike Inactive DFGin 6.159 14.181 BLAminus -129.46, 178.87 65.25, 87.62 -100.45, 24.31 288.53, 78.58 -69.31, -13.11 in-in in 7.758 Saltbr-in 2.635 HRD-in -73.88, -45.26 75.34, -0.8 in-in-out SNCiio in-out ActLoopNT-in 2.758 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_oooo APE10-dihe-na -97.88, 176.26 APE9-dihe-na 47.04, -123.5 APE8-dihe-out -91.29, -3.22 APE8-rot-out 60.74 APE67-dihe-in -61.44, -18.49 -67.89, -32.09 APE12-dist-out 23.433 APE11-dist-out 18.481 APE10-dist-out 19.369 APE9-dist-out 12.347 None None MSE903,MSE959,MSE1037,MSE1066,MSE1073,MSE1090,MSE1134,MSE1166,MSE1176 XRAY 1.98 0.202 0.221 A 327 286 30 0 0 16 [[874, 1175]] 1.0 8jup Oryza sativa OTHER_FLS2_ORYSJ TKL 3.2e-44 157.5 4 265 262 1030 1031 1032 1034 1036 908 926 930 1010 1012 1011 1013 1081 1069 1064 1063 1062 1061 1060 1059 1058 957 LRR receptor-like serine/threonine-protein kinase FLS2
CMGC CK1 Q8IIR9_PLAF7 5XVUA Q8IIR9 12 332 335.0 ATP:403 ATPlike Inactive DFGin 7.321 16.711 BLAminus -110.04, -170.26 56.43, 69.12 -91.86, 16.9 294.29, 86.98 -66.48, -34.8 in-in in 9.452 Saltbr-in 2.802 HRD-in -73.92, -41.02 61.9, 9.67 in-in-out SNCiio in-out ActLoopNT-in 2.966 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -133.27, 163.04 APE9-dihe-na 66.36, 159.74 APE8-dihe-in -64.44, 138.76 APE8-rot-out 161.92 APE67-dihe-in -63.63, -26.0 -45.45, -45.73 APE12-dist-in 12.799 APE11-dist-in 10.78 APE10-dist-in 6.004 APE9-dist-in 3.652 None None None XRAY 3.0 0.174 0.216 A 332 321 0 0 0 0 [[43, 328]] 1.0 5xvu Plasmodium falciparum CMGC_CK1_PLAF7 CMGC 2.9e-67 232.9 1 301 301 178 179 180 182 184 72 85 89 157 159 158 160 218 205 200 199 198 197 196 195 194 118 non-specific serine/threonine protein kinase
CMGC CK1 Q8IIR9_PLAF7 5XVUB Q8IIR9 12 332 335.0 ATP:404 ATPlike Inactive DFGin 7.401 16.674 BLAminus -109.75, -170.19 56.85, 69.23 -92.76, 17.97 295.03, 87.19 -67.17, -35.33 in-in in 9.301 Saltbr-in 2.793 HRD-in -71.07, -41.36 62.96, 8.73 in-in-out SNCiio in-out ActLoopNT-in 2.864 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -122.62, -85.86 APE9-dihe-na -52.99, 173.24 APE8-dihe-in -65.9, 138.47 APE8-rot-out 161.08 APE67-dihe-in -63.67, -25.37 -44.18, -46.51 APE12-dist-in 12.744 APE11-dist-in 10.615 APE10-dist-in 5.941 APE9-dist-in 3.597 None None None XRAY 3.0 0.174 0.216 B 332 321 0 0 0 0 [[43, 328]] 1.0 5xvu Plasmodium falciparum CMGC_CK1_PLAF7 CMGC 2.9e-67 232.9 1 301 301 178 179 180 182 184 72 85 89 157 159 158 160 218 205 200 199 198 197 196 195 194 118 non-specific serine/threonine protein kinase
CMGC CK1 Q8IIR9_PLAF7 5XVUC Q8IIR9 12 332 335.0 ATP:405 ATPlike Inactive DFGin 7.492 16.742 BLAminus -109.76, -170.14 57.17, 68.62 -92.1, 18.51 294.14, 87.94 -67.81, -35.21 in-in in 9.456 Saltbr-in 2.808 HRD-in -70.49, -40.6 62.72, 9.24 in-in-out SNCiio in-out ActLoopNT-in 2.942 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -116.02, -79.39 APE9-dihe-na -60.1, 172.38 APE8-dihe-in -65.34, 140.21 APE8-rot-out 160.23 APE67-dihe-in -64.3, -24.41 -46.46, -45.68 APE12-dist-in 12.741 APE11-dist-in 10.642 APE10-dist-in 5.845 APE9-dist-in 3.632 None None None XRAY 3.0 0.174 0.216 C 332 321 0 0 0 0 [[43, 328]] 1.0 5xvu Plasmodium falciparum CMGC_CK1_PLAF7 CMGC 2.9e-67 232.9 1 301 301 178 179 180 182 184 72 85 89 157 159 158 160 218 205 200 199 198 197 196 195 194 118 non-specific serine/threonine protein kinase
CMGC MAPK1 MK01_RAT 4GT3A P63086 9 356 358.0 ATP:402 ATPlike Inactive DFGin 6.703 16.144 BLAminus -134.54, -176.44 66.94, 76.71 -104.84, 22.9 282.81, 76.31 -55.64, -34.0 in-none in 9.817 Saltbr-none 999.0 HRD-in -69.89, -50.79 79.79, -14.59 none-in-out SNCnio in-out ActLoopNT-in 2.776 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -105.46, -44.03 APE9-dihe-na -70.04, 169.29 APE8-dihe-in -70.71, 123.51 APE8-rot-in 309.48 APE67-dihe-in -61.98, -17.54 -56.41, -47.97 APE12-dist-out 14.289 APE11-dist-in 11.003 APE10-dist-in 6.74 APE9-dist-in 4.422 None None CME159 XRAY 1.68 0.168 0.2 A 364 348 0 0 0 0 [[23, 311]] 1.0 4gt3 Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.4e-85 293.1 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
CMGC MAPK1 MK01_RAT 1GOLA P63086 2 358 358.0 ATP:581 ATPlike Inactive DFGin 6.84 16.509 BLAminus -138.32, 175.35 71.89, 79.82 -106.15, 29.68 287.28, 71.38 -70.4, -19.75 out-none out 10.408 Saltbr-none 999.0 HRD-in -68.54, -52.86 75.92, 1.19 none-in-out SNCnio in-out ActLoopNT-in 2.899 ActLoopCT-out nonTYR APEdihe_aaiii APEdist_oiii APE10-dihe-na -103.2, -24.36 APE9-dihe-na -62.06, 164.48 APE8-dihe-in -61.17, 119.13 APE8-rot-in 302.33 APE67-dihe-in -53.15, -25.45 -41.46, -58.53 APE12-dist-out 14.339 APE11-dist-in 11.207 APE10-dist-in 7.401 APE9-dist-in 4.282 K52R None None XRAY 2.8 999.0 999.0 A 364 357 0 0 0 0 [[23, 311]] 1.0 1gol Rattus norvegicus CMGC_MAPK1_RAT CMGC 1.4e-84 289.8 1 301 301 164 165 166 168 170 52 69 73 144 146 145 147 208 195 190 189 188 187 186 185 184 104 Mitogen-activated protein kinase 1
STE TAOK2 TAOK2_RAT 1U5RA Q9JLS3 12 320 1235.0 ATP:411 ATPlike Active DFGin 6.99 14.24 BLAminus -128.27, -174.18 56.24, 80.49 -99.99, 21.83 293.09, 83.93 -60.11, -26.41 in-in in 8.687 Saltbr-in 2.887 HRD-in -75.95, -53.43 76.2, -2.14 in-in-in SNCiii in-in ActLoopNT-in 2.767 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -139.19, 153.0 APE9-dihe-na 135.08, -166.49 APE8-dihe-in -116.65, 119.51 APE8-rot-in 301.53 APE67-dihe-in -56.87, -24.9 -27.41, -63.55 APE12-dist-in 8.446 APE11-dist-in 11.391 APE10-dist-in 5.507 APE9-dist-in 3.279 None SEP181 SEP181 XRAY 2.1 0.211 0.244 A 348 309 0 0 0 0 [[28, 281]] 1.0 1u5r Rattus norvegicus STE_TAOK2_RAT STE 1.4e-89 305.8 2 257 256 168 169 170 172 174 57 76 80 148 150 149 151 207 192 187 186 185 184 183 182 181 106 Serine/threonine-protein kinase TAO2
STE TAOK2 TAOK2_RAT 1U5RB Q9JLS3 12 320 1235.0 ATP:412 ATPlike Active DFGin 6.763 13.896 BLAminus -129.03, -178.62 56.08, 82.23 -96.99, 22.88 295.53, 83.61 -63.46, -23.11 in-in in 8.772 Saltbr-in 2.623 HRD-in -71.62, -50.86 71.95, 2.83 in-in-in SNCiii in-in ActLoopNT-in 2.776 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -140.4, 155.39 APE9-dihe-na 130.83, -165.29 APE8-dihe-in -116.7, 116.24 APE8-rot-in 302.47 APE67-dihe-in -61.68, -22.51 -24.84, -62.59 APE12-dist-in 8.905 APE11-dist-in 11.02 APE10-dist-in 5.282 APE9-dist-in 3.304 None SEP181 SEP181 XRAY 2.1 0.211 0.244 B 348 309 0 0 0 0 [[28, 281]] 1.0 1u5r Rattus norvegicus STE_TAOK2_RAT STE 1.4e-89 305.8 2 257 256 168 169 170 172 174 57 76 80 148 150 149 151 207 192 187 186 185 184 183 182 181 106 Serine/threonine-protein kinase TAO2
CMGC CKA1 CSK21_YEAST 4FI1A P15790 1 371 372.0 ATP:403 ATPlike Inactive None 23.938 16.237 None -116.2, -173.62 60.19, 79.18 -100.6, 15.4 291.83, 86.61 -72.61, -17.46 out-na out 37.858 Saltbr-na 999.0 HRD-in -72.28, -48.07 67.04, 8.76 na-in-out SNCaio in-out ActLoopNT-in 2.926 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -132.66, 175.92 APE9-dihe-na 60.75, -165.68 APE8-dihe-in -116.66, 152.71 APE8-rot-out 187.49 APE67-dihe-in -64.93, -21.65 -39.27, -55.57 APE12-dist-in 12.741 APE11-dist-in 10.923 APE10-dist-in 6.072 APE9-dist-in 3.419 None None None XRAY 2.09 0.206 0.243 A 374 371 0 0 0 0 [[100, 363]] 1.0 4fi1 Saccharomyces cerevisiae CMGC_CKA1_YEAST CMGC 0.0001 199.7 1 55 321 213 214 215 217 219 69 114 118 192 194 193 195 253 240 235 234 233 232 231 230 229 153 Casein kinase II subunit alpha
CMGC CKA1 CSK21_YEAST 4MWHA P15790 1 371 372.0 ATP:401 ATPlike Inactive None 23.978 16.218 None -116.51, -173.69 61.16, 78.03 -99.81, 14.04 291.24, 86.36 -72.33, -17.88 out-na out 37.853 Saltbr-na 999.0 HRD-in -70.43, -48.46 67.2, 9.69 na-in-out SNCaio in-out ActLoopNT-in 2.96 ActLoopCT-out nonTYR APEdihe_aaioi APEdist_iiii APE10-dihe-na -135.3, 175.12 APE9-dihe-na 58.95, -171.53 APE8-dihe-in -112.48, 153.51 APE8-rot-out 184.1 APE67-dihe-in -66.06, -21.26 -39.33, -54.63 APE12-dist-in 12.731 APE11-dist-in 10.923 APE10-dist-in 6.071 APE9-dist-in 3.479 None None None XRAY 2.09 0.199 0.241 A 374 371 0 0 0 0 [[100, 363]] 1.0 4mwh Saccharomyces cerevisiae CMGC_CKA1_YEAST CMGC 0.0001 199.7 1 55 321 213 214 215 217 219 69 114 118 192 194 193 195 253 240 235 234 233 232 231 230 229 153 Casein kinase II subunit alpha
CMGC SKY1 SKY1_YEAST 1Q97A Q03656 144 737 742.0 ATP:60485 ATPlike Active DFGin 5.605 12.648 BLAminus -113.61, -176.06 45.65, 81.54 -92.49, 25.33 294.84, 21.0 -61.4, -14.56 in-in in 8.92 Saltbr-in 2.91 HRD-in -73.18, -42.39 69.86, -2.96 in-in-in SNCiii in-in ActLoopNT-in 2.985 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -115.18, 168.88 APE9-dihe-na 68.54, 141.02 APE8-dihe-in -74.6, 131.99 APE8-rot-in 300.34 APE67-dihe-in -58.79, -28.16 -13.13, -73.4 APE12-dist-in 12.586 APE11-dist-in 10.498 APE10-dist-in 7.631 APE9-dist-in 3.163 None None None XRAY 2.3 0.215 0.264 A 373 351 11 0 0 0 [[158, 706]] 1.0 1q97 Saccharomyces cerevisiae CMGC_SKY1_YEAST CMGC 8.8e-100 339.7 1 301 301 549 550 551 553 555 187 202 206 291 293 292 294 586 574 569 568 567 566 565 564 563 247 Serine/threonine-protein kinase SKY1
OTHER GCN2-2 GCN2_YEAST 1ZYDA P15442 594 996 1659.0 ATP:60303 ATPlike Inactive DFGin 6.41 14.106 BLBminus -140.51, -168.68 57.3, 45.16 -50.27, 137.38 287.66, 72.18 -82.02, 105.81 out-out out 12.801 Saltbr-out 11.502 HRD-in -64.16, -46.0 70.86, 0.79 out-out-out SNCooo out-out ActLoopNT-out 8.833 ActLoopCT-out nonTYR APEdihe_aaooi APEdist_nnoo APE10-dihe-na 999.0, 87.46 APE9-dihe-na 82.34, -63.68 APE8-dihe-out -63.29, -19.6 APE8-rot-out 172.58 APE67-dihe-in -77.43, -0.66 -78.79, -26.91 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 18.861 APE9-dist-out 12.094 None None None XRAY 2.75 0.208 0.27 A 303 268 32 0 0 26 [[292, 527], [599, 981]] 2.0 1zyd Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 7.9e-45 164.1 2 254 253 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
OTHER GCN2-2 GCN2_YEAST 1ZYDB P15442 594 983 1659.0 ATP:60304 ATPlike Inactive DFGin 6.558 14.184 BLBminus -148.24, -169.36 49.61, 62.39 -64.34, 151.67 288.08, 61.76 -84.72, 102.57 out-out out 12.647 Saltbr-out 11.162 HRD-in -64.07, -43.6 67.43, 4.77 out-none-out SNCono none-out ActLoopNT-none 999.0 ActLoopCT-out nonTYR APEdihe_aaoii APEdist_nnoo APE10-dihe-na 999.0, 127.88 APE9-dihe-na -94.37, -36.47 APE8-dihe-out -54.75, -25.46 APE8-rot-in 302.91 APE67-dihe-in -57.91, -12.21 -57.71, -47.35 APE12-dist-none 999.0 APE11-dist-none 999.0 APE10-dist-out 17.788 APE9-dist-out 11.857 None None None XRAY 2.75 0.208 0.27 B 303 251 36 0 0 27 [[292, 527], [599, 981]] 2.0 1zyd Saccharomyces cerevisiae OTHER_GCN2-2_YEAST NEK 7.9e-45 164.1 2 254 253 852 853 854 856 858 628 643 647 832 834 833 835 907 894 889 888 887 886 885 884 883 789 eIF-2-alpha kinase GCN2
TKL NCGRLOCUS634 A0ACD6BAX3_9POAL 8HO6A A0ACD6BAX3 7 305 312.0 ATP:60401 ATPlike Active DFGin 6.377 15.619 BLAminus -139.79, 171.9 63.28, 66.12 -93.24, 62.65 279.35, 60.61 -82.08, -30.35 in-in in 8.644 Saltbr-in 2.728 HRD-in -60.88, -41.53 70.8, -58.95 in-in-in SNCiii in-in ActLoopNT-in 2.72 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -127.65, 146.26 APE9-dihe-na 148.14, -156.83 APE8-dihe-in -124.83, 132.59 APE8-rot-in 314.24 APE67-dihe-inflip 93.19, -27.63 -56.53, 137.58 APE12-dist-in 9.991 APE11-dist-in 11.771 APE10-dist-in 6.261 APE9-dist-in 5.587 None TPO184,SEP187,TPO188 TPO184,SEP187,TPO188 XRAY 2.1 0.206 0.234 A 326 281 18 0 0 2 [[22, 302]] 1.0 8ho6 Saccharum hybrid cultivar TKL_NCGRLOCUS634_9POAL TKL 3.7e-60 209.7 4 266 263 170 171 172 174 176 58 74 78 150 152 151 153 212 200 195 194 193 192 191 190 189 104 ScRIPK kinase protein
CK1 CKI1 CKI1_SCHPO 1CSNA P40233 6 298 446.0 ATP:299 ATPlike Active DFGin 6.422 13.79 BLAminus -124.8, 177.22 63.85, 88.12 -109.85, 36.77 298.25, 97.14 -71.61, -21.33 in-in in 8.04 Saltbr-in 3.086 HRD-in -68.74, -48.02 63.6, 9.84 in-in-in SNCiii in-in ActLoopNT-in 2.815 ActLoopCT-in nonTYR APEdihe_aaiii APEdist_iiii APE10-dihe-na -97.61, -90.82 APE9-dihe-na -65.25, -165.09 APE8-dihe-in -55.42, 111.92 APE8-rot-in 313.89 APE67-dihe-in -55.02, -31.3 -55.98, -42.83 APE12-dist-in 12.741 APE11-dist-in 13.007 APE10-dist-in 7.16 APE9-dist-in 4.794 None None None XRAY 2.0 0.207 999.0 A 298 293 0 0 0 0 [[12, 280]] 1.0 1csn Schizosaccharomyces pombe CK1_CKI1_SCHPO CK1 8e-95 323.1 1 261 261 153 154 155 157 159 41 55 59 128 130 129 131 200 188 183 182 181 180 179 178 177 86 Casein kinase I homolog 1
OTHER None A0ACD6BAW3_SERSF 5HNVA A0ACD6BAW3 11 298 302.0 ATP:401 ATPlike Inactive DFGin 5.795 14.621 ABAminus -94.42, -26.67 -170.11, 138.36 -108.4, 3.69 302.8, 148.02 68.44, 20.57 in-out in 9.647 Saltbr-out 4.566 HRD-in -80.79, -61.26 75.18, 6.43 out-out-out SNCooo out-out ActLoopNT-out 13.684 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oioo APE10-dihe-na -88.14, -69.33 APE9-dihe-na -95.59, 155.7 APE8-dihe-in -98.36, 112.37 APE8-rot-na 291.69 APE67-dihe-inflip 93.41, -27.11 -58.56, 130.7 APE12-dist-out 15.321 APE11-dist-in 10.428 APE10-dist-out 9.582 APE9-dist-out 6.196 None None None XRAY 1.41 0.184 0.21 A 302 283 5 0 0 0 [[23, 295]] 1.0 5hnv Serratia sp. OTHER_None_SERSF NEK 2.2e-22 86.3 1 248 248 182 183 184 186 188 52 89 93 162 164 163 165 225 210 205 204 203 202 201 200 199 119 PpkA N terminal
OTHER None A0ACD6BAW3_SERSF 5X1QA A0ACD6BAW3 11 298 302.0 ATP:401 ATPlike Inactive DFGin 5.865 14.558 ABAminus -93.66, -25.98 -170.98, 138.82 -108.48, 3.27 301.84, 148.6 67.38, 20.55 in-out in 9.63 Saltbr-out 4.483 HRD-in -78.8, -61.79 72.35, 9.48 out-out-out SNCooo out-out ActLoopNT-out 13.651 ActLoopCT-out nonTYR APEdihe_aaiai APEdist_oioo APE10-dihe-na -91.65, -68.57 APE9-dihe-na -94.63, 156.7 APE8-dihe-in -100.49, 112.2 APE8-rot-na 291.2 APE67-dihe-inflip 90.51, -24.59 -59.25, 132.18 APE12-dist-out 15.327 APE11-dist-in 10.443 APE10-dist-out 9.615 APE9-dist-out 6.227 None None None XRAY 1.602 0.181 0.212 A 302 283 5 0 0 0 [[23, 295]] 1.0 5x1q Serratia sp. OTHER_None_SERSF NEK 2.2e-22 86.3 1 248 248 182 183 184 186 188 52 89 93 162 164 163 165 225 210 205 204 203 202 201 200 199 119 PpkA N terminal